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Search of human proteins with 187173290
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187173290 troponin T1, skeletal, slow isoform b [Homo
sapiens]
(262 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens] 522 e-148
gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens] 511 e-145
gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens] 490 e-139
gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens] 325 2e-89
gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens] 323 7e-89
gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens] 322 2e-88
gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens] 321 4e-88
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens] 318 2e-87
gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens] 318 3e-87
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens] 318 4e-87
gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens] 314 4e-86
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 69 4e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 69 4e-12
gi|148746195 trichohyalin [Homo sapiens] 69 5e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 64 1e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 61 9e-10
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 61 1e-09
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 61 1e-09
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 60 1e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 60 2e-09
gi|92859701 myosin VI [Homo sapiens] 60 3e-09
gi|134152708 arginine and glutamate rich 1 [Homo sapiens] 59 4e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 58 1e-08
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 56 3e-08
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 56 3e-08
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 56 3e-08
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 56 3e-08
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 56 3e-08
gi|34878777 ring finger protein 20 [Homo sapiens] 56 3e-08
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 56 3e-08
>gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens]
Length = 262
Score = 522 bits (1344), Expect = e-148
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER
Sbjct: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK
Sbjct: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE
Sbjct: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN
Sbjct: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
Query: 241 RISHAQKFRKGAGKGRVGGRWK 262
RISHAQKFRKGAGKGRVGGRWK
Sbjct: 241 RISHAQKFRKGAGKGRVGGRWK 262
>gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens]
Length = 278
Score = 511 bits (1317), Expect = e-145
Identities = 262/278 (94%), Positives = 262/278 (94%), Gaps = 16/278 (5%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER
Sbjct: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK
Sbjct: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE
Sbjct: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
Query: 181 MKVRILSERKKPLDIDYMGEEQL----------------REKAQELSDWIHQLESEKFDL 224
MKVRILSERKKPLDIDYMGEEQL REKAQELSDWIHQLESEKFDL
Sbjct: 181 MKVRILSERKKPLDIDYMGEEQLRARSAWLPPSQPSCPAREKAQELSDWIHQLESEKFDL 240
Query: 225 MAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
MAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK
Sbjct: 241 MAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 278
>gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens]
Length = 251
Score = 490 bits (1262), Expect = e-139
Identities = 251/262 (95%), Positives = 251/262 (95%), Gaps = 11/262 (4%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MSDTEEQEYEEEQPEEEAAEEEEE EEERPKPSRPVVPPLIPPKIPEGER
Sbjct: 1 MSDTEEQEYEEEQPEEEAAEEEEE-----------EEERPKPSRPVVPPLIPPKIPEGER 49
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK
Sbjct: 50 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 109
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE
Sbjct: 110 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 169
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN
Sbjct: 170 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 229
Query: 241 RISHAQKFRKGAGKGRVGGRWK 262
RISHAQKFRKGAGKGRVGGRWK
Sbjct: 230 RISHAQKFRKGAGKGRVGGRWK 251
>gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens]
Length = 258
Score = 325 bits (834), Expect = 2e-89
Identities = 168/265 (63%), Positives = 208/265 (78%), Gaps = 10/265 (3%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MSD E ++ EE+ EEE A+EEEE E+ + EEE+P+P L PKIPEGE+
Sbjct: 1 MSDEEVEQVEEQYEEEEEAQEEEEVQEDTAE-EDAEEEKPRPK------LTAPKIPEGEK 53
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
VDFDDI +KR KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EK
Sbjct: 54 VDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEK 113
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
ERERQ +LAEEK R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT RE
Sbjct: 114 ERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTARE 173
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
MK +IL+ER+KPL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I L +
Sbjct: 174 MKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRS 233
Query: 241 RISHAQKFRKGAG---KGRVGGRWK 262
RI AQK K AG KG+VGGRWK
Sbjct: 234 RIDQAQKHSKKAGTPAKGKVGGRWK 258
>gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
Length = 285
Score = 323 bits (829), Expect = 7e-89
Identities = 178/287 (62%), Positives = 211/287 (73%), Gaps = 27/287 (9%)
Query: 1 MSDTEE--QEYEEEQPEEEAAEEEEEAPEEP-EPVAEPEEER------------------ 39
MSD EE +EYEEE+ EE A EE+EEA EE E AE EE R
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
Query: 40 ----PKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEE 95
PKP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ HFE RKKEEEE
Sbjct: 61 EESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
Query: 96 LVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLS 155
LV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AED+A+KKK LS
Sbjct: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
Query: 156 NMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIH 215
NM HFGGY+ K E+K GKRQT RE K +IL+ER+K L ID++ E+QLREKA+EL I+
Sbjct: 180 NM-MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIY 238
Query: 216 QLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
LE+EKFDL K KQQKYEINVL NRI+ QK K GK +V GRWK
Sbjct: 239 NLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
>gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens]
Length = 256
Score = 322 bits (826), Expect = 2e-88
Identities = 170/265 (64%), Positives = 208/265 (78%), Gaps = 12/265 (4%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MSD E ++ EE+ EEE E +EEA E E V EPEE +P+P L PKIPEGE+
Sbjct: 1 MSDEEVEQVEEQYEEEE--EAQEEAAEVHEEVHEPEE-KPRPK------LTAPKIPEGEK 51
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
VDFDDI +KR KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EK
Sbjct: 52 VDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEK 111
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
ERERQ +LAEEK R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT RE
Sbjct: 112 ERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTARE 171
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
MK +IL+ER+KPL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I L +
Sbjct: 172 MKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRS 231
Query: 241 RISHAQKFRKGAG---KGRVGGRWK 262
RI AQK K AG KG+VGGRWK
Sbjct: 232 RIDQAQKHSKKAGTPAKGKVGGRWK 256
>gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens]
Length = 250
Score = 321 bits (823), Expect = 4e-88
Identities = 168/265 (63%), Positives = 205/265 (77%), Gaps = 18/265 (6%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MSD E ++ EE+ EEE A+EEEE EE +P RPK L PKIPEGE+
Sbjct: 1 MSDEEVEQVEEQYEEEEEAQEEEEVQEEEKP-------RPK--------LTAPKIPEGEK 45
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
VDFDDI +KR KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EK
Sbjct: 46 VDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEK 105
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
ERERQ +LAEEK R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT RE
Sbjct: 106 ERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTARE 165
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
MK +IL+ER+KPL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I L +
Sbjct: 166 MKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRS 225
Query: 241 RISHAQKFRKGAG---KGRVGGRWK 262
RI AQK K AG KG+VGGRWK
Sbjct: 226 RIDQAQKHSKKAGTPAKGKVGGRWK 250
>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
Length = 295
Score = 318 bits (816), Expect = 2e-87
Identities = 177/297 (59%), Positives = 211/297 (71%), Gaps = 37/297 (12%)
Query: 1 MSDTEE--QEYEEEQPEEEAAEEEEE-----------APEEPEPVAEPEEER-------- 39
MSD EE +EYEEE+ EE A EEEE+ A E+ E AE EE R
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEE 60
Query: 40 --------------PKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVH 85
PKP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ H
Sbjct: 61 EAKEAEDGPMEESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAH 119
Query: 86 FEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAE 145
FE RKKEEEELV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AE
Sbjct: 120 FENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAE 179
Query: 146 DDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLRE 205
D+A+KKK LSNM HFGGY+ K E+K GKRQT RE K +IL+ER+K L ID++ E+QLRE
Sbjct: 180 DEARKKKALSNM-MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLRE 238
Query: 206 KAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
KA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK K GK +V GRWK
Sbjct: 239 KAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 295
>gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
Length = 288
Score = 318 bits (815), Expect = 3e-87
Identities = 178/290 (61%), Positives = 211/290 (72%), Gaps = 30/290 (10%)
Query: 1 MSDTEE--QEYEEEQPEEEAAEEEEEAPEEP-EPVAEPEEER------------------ 39
MSD EE +EYEEE+ EE A EE+EEA EE E AE EE R
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
Query: 40 ----PKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEE 95
PKP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ HFE RKKEEEE
Sbjct: 61 EESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
Query: 96 LVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLS 155
LV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AED+A+KKK LS
Sbjct: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
Query: 156 NMGAHFGGYLVK---AEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSD 212
NM HFGGY+ K E+K GKRQT RE K +IL+ER+K L ID++ E+QLREKA+EL
Sbjct: 180 NM-MHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQ 238
Query: 213 WIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
I+ LE+EKFDL K KQQKYEINVL NRI+ QK K GK +V GRWK
Sbjct: 239 SIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
Length = 282
Score = 318 bits (814), Expect = 4e-87
Identities = 176/284 (61%), Positives = 211/284 (74%), Gaps = 24/284 (8%)
Query: 1 MSDTEE--QEYEEEQPEE--EAAEEEEEAPEEPEPVAEPEEE----------------RP 40
MSD EE +EYEEE+ EE EAAEE+ EA E E E+E +P
Sbjct: 1 MSDIEEVVEEYEEEEQEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKP 60
Query: 41 KPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALK 100
KP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ HFE RKKEEEELV+LK
Sbjct: 61 KP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 119
Query: 101 ERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAH 160
+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AED+A+KKK LSNM H
Sbjct: 120 DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM-MH 178
Query: 161 FGGYLVKA--EQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLE 218
FGGY+ KA E+K GKRQT RE K +IL+ER+K L ID++ E+QLREKA+EL I+ LE
Sbjct: 179 FGGYIQKAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE 238
Query: 219 SEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
+EKFDL K KQQKYEINVL NRI+ QK K GK +V GRWK
Sbjct: 239 AEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 282
>gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens]
Length = 250
Score = 314 bits (805), Expect = 4e-86
Identities = 165/265 (62%), Positives = 203/265 (76%), Gaps = 18/265 (6%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MSD E ++ EE+ EEE A+EEEE EE +P RPK L PKIPEGE+
Sbjct: 1 MSDEEVEQVEEQYEEEEEAQEEEEVQEEEKP-------RPK--------LTAPKIPEGEK 45
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
VDFDDI +KR KDL+ELQ LID HFE RKKEEEELVALKERIE+RR+ERAEQQR R EK
Sbjct: 46 VDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEK 105
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
ERERQ +LAEEK R+EEE+AK+RAEDD KKKK LS+MGA++ YL KA+QKRGK+QT RE
Sbjct: 106 ERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTARE 165
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
MK +IL+ER+KPL+ID++GE++LR+KA+EL + +HQLE +KF+ KLK+QKY+I +
Sbjct: 166 MKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDIMNVRA 225
Query: 241 RISHAQKFRKGAG---KGRVGGRWK 262
R+ KF K AG KG+VGGRWK
Sbjct: 226 RVQMLAKFSKKAGTPAKGKVGGRWK 250
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 68.9 bits (167), Expect = 4e-12
Identities = 62/221 (28%), Positives = 99/221 (44%), Gaps = 43/221 (19%)
Query: 22 EEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTL 81
++ PEEP V E E+++ + PV F+D R+ E+ LEL+
Sbjct: 326 DQRLPEEP--VLEDEQQQLEKKLPVT---------------FEDKKRENFERGNLELEKR 368
Query: 82 IDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK-ERERQAKLAEEKMRKEEEEA 140
EQ++KE+E L L ER E+ R ER Q++ R + E E+Q + E R+ EEE
Sbjct: 369 RQALLEQQRKEQERLAQL-ERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEER 427
Query: 141 KKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQ------TGREMKVRILSERKKPLD 194
+K E K+ L + E +R +RQ + + +L +KK L+
Sbjct: 428 RKEIERREAAKRELERQR--------QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLE 479
Query: 195 IDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
+ + L+D HQLE + D+ +L Q+ EI
Sbjct: 480 FE----------LEALNDKKHQLEGKLQDIRCRLTTQRQEI 510
Score = 46.2 bits (108), Expect = 3e-05
Identities = 30/102 (29%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVAL---KERIERRRSERAEQ--QRFRTE 119
+IH K+ L+ Q ++ ++K++E +++ L KE +RR ER +Q + + E
Sbjct: 612 EIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQE 667
Query: 120 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF 161
E +R KL EE+ K EE KK+ ++ K++ +G F
Sbjct: 668 DEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLF 709
Score = 35.0 bits (79), Expect = 0.066
Identities = 50/250 (20%), Positives = 115/250 (46%), Gaps = 30/250 (12%)
Query: 2 SDTEEQEYE-EEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
++ E +E E +EQ + E E++ ++ E + EEER K +I E
Sbjct: 389 AEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRK------------EIERREA 436
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
+ ++++E + Q L++ QR KE+E++V LK ++++ E + +K
Sbjct: 437 AKRELERQRQLEWERNRRQELLN----QRNKEQEDIVVLK---AKKKTLEFELEAL-NDK 488
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
+ + + KL + + R + ++ E K +++ H L +++Q G+ ++
Sbjct: 489 KHQLEGKLQDIRCRLTTQ--RQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQ 546
Query: 181 MKVRILSERKKPLDIDYMGEEQL--REKAQELSDWIHQLESEKFDLMAKLKQQK-YEINV 237
IL+++ K + + + + L ++A E + Q ++ D + K + K EI++
Sbjct: 547 ----ILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDI 602
Query: 238 LYNRISHAQK 247
N++ ++
Sbjct: 603 FNNQLKELRE 612
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 68.9 bits (167), Expect = 4e-12
Identities = 62/221 (28%), Positives = 99/221 (44%), Gaps = 43/221 (19%)
Query: 22 EEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTL 81
++ PEEP V E E+++ + PV F+D R+ E+ LEL+
Sbjct: 326 DQRLPEEP--VLEDEQQQLEKKLPVT---------------FEDKKRENFERGNLELEKR 368
Query: 82 IDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK-ERERQAKLAEEKMRKEEEEA 140
EQ++KE+E L L ER E+ R ER Q++ R + E E+Q + E R+ EEE
Sbjct: 369 RQALLEQQRKEQERLAQL-ERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEER 427
Query: 141 KKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQ------TGREMKVRILSERKKPLD 194
+K E K+ L + E +R +RQ + + +L +KK L+
Sbjct: 428 RKEIERREAAKRELERQR--------QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLE 479
Query: 195 IDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
+ + L+D HQLE + D+ +L Q+ EI
Sbjct: 480 FE----------LEALNDKKHQLEGKLQDIRCRLTTQRQEI 510
Score = 46.2 bits (108), Expect = 3e-05
Identities = 30/102 (29%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVAL---KERIERRRSERAEQ--QRFRTE 119
+IH K+ L+ Q ++ ++K++E +++ L KE +RR ER +Q + + E
Sbjct: 612 EIHNKQQ----LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQE 667
Query: 120 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF 161
E +R KL EE+ K EE KK+ ++ K++ +G F
Sbjct: 668 DEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLF 709
Score = 35.0 bits (79), Expect = 0.066
Identities = 50/250 (20%), Positives = 115/250 (46%), Gaps = 30/250 (12%)
Query: 2 SDTEEQEYE-EEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
++ E +E E +EQ + E E++ ++ E + EEER K +I E
Sbjct: 389 AEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRK------------EIERREA 436
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
+ ++++E + Q L++ QR KE+E++V LK ++++ E + +K
Sbjct: 437 AKRELERQRQLEWERNRRQELLN----QRNKEQEDIVVLK---AKKKTLEFELEAL-NDK 488
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
+ + + KL + + R + ++ E K +++ H L +++Q G+ ++
Sbjct: 489 KHQLEGKLQDIRCRLTTQ--RQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQ 546
Query: 181 MKVRILSERKKPLDIDYMGEEQL--REKAQELSDWIHQLESEKFDLMAKLKQQK-YEINV 237
IL+++ K + + + + L ++A E + Q ++ D + K + K EI++
Sbjct: 547 ----ILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDI 602
Query: 238 LYNRISHAQK 247
N++ ++
Sbjct: 603 FNNQLKELRE 612
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.6 bits (166), Expect = 5e-12
Identities = 56/251 (22%), Positives = 117/251 (46%), Gaps = 24/251 (9%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
E+Q+ E+ + EEEE+ + E V EEE+ + P + + + +++
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 65 DIHRKRMEKD-----LLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE 119
++ R+R E++ L Q L E+R++++EE +ER E++ R +Q R E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 120 KERERQAKLAEEKMRKE-----EEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGK 174
+ RE+Q + +E+ R+E E+E ++R + +++++ L + +Q R +
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 175 RQTGREMKVRILSERKKPLDIDYMGEEQ--------------LREKAQELSDWIHQLESE 220
+Q RE ++R + ++ + EE+ L+ + +E DW+ + E
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 221 KFDLMAKLKQQ 231
+ + KQQ
Sbjct: 465 ERHEQERRKQQ 475
Score = 60.5 bits (145), Expect = 1e-09
Identities = 54/212 (25%), Positives = 105/212 (49%), Gaps = 33/212 (15%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPE---EPEPVAEPEEERPKPSRPVVPPLIPPKIPEGE 59
+ EQ++E+E+ E+ E+EE + E E+ER K + E E
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK--------RDQEEE 483
Query: 60 RVDF-----DDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQ 114
R + ++ R++ E+ +L+ + EQR K +EE L++R+ R+EQQ
Sbjct: 484 RRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL------RSEQQ 537
Query: 115 RFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGK 174
R ++ER Q EE+ R E+E ++R + + ++++ L+K E++R +
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERR----------DQLLKREEERRQ 587
Query: 175 RQTGREMKVRILSERKKPLDIDYMGEEQLREK 206
++ RE + R L +R K +++ + +E+ RE+
Sbjct: 588 QRLKREQEER-LEQRLKREEVERLEQEERREQ 618
Score = 59.3 bits (142), Expect = 3e-09
Identities = 59/232 (25%), Positives = 109/232 (46%), Gaps = 29/232 (12%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE+ E+++ E+ E+E E + EEER + L + E++
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL-LK 551
Query: 65 DIHRKRMEKDLLE--LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER 122
KR+E++ E L+ + +Q K EEE ++R++R + ER EQ+ R E ER
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEE--RRQQRLKREQEERLEQRLKREEVER 609
Query: 123 ERQAKLAEEKMRKEEEEAKKR-----AEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQT 177
Q + E+++++EE E ++R +E+ ++++ L + +Q+R +++
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ----------QQLRREQQERREQRL 659
Query: 178 GREMKVRILSERKKPLDIDYMGEEQLREKAQE---------LSDWIHQLESE 220
RE + L +R K + E++L E+ QE + W QLESE
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Score = 58.5 bits (140), Expect = 6e-09
Identities = 65/295 (22%), Positives = 129/295 (43%), Gaps = 50/295 (16%)
Query: 3 DTEEQEYEEEQ------------PEEEA-----------------------------AEE 21
+ EE+ EEEQ P+EE EE
Sbjct: 182 EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241
Query: 22 EEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKD-----LL 76
EE+ + E V EEE+ + P + + + +++ ++ R+R E++ L
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301
Query: 77 ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKE 136
Q L E+R++++EE +ER E ++ ER EQQ R ++ER Q E++ +
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERRE-QQEERREQQLRREQEERREQQLRREQEEERR 360
Query: 137 EEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID 196
E++ ++ E++ +++++ L + +Q R ++Q RE ++R E++ +
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR--REQQLRREQQ 418
Query: 197 YMGEEQL-REKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 250
E+QL RE+ +E + H+ E + L + ++++ + H Q+ RK
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Score = 58.2 bits (139), Expect = 7e-09
Identities = 55/250 (22%), Positives = 118/250 (47%), Gaps = 22/250 (8%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVD 62
+ E +E +EE+ E++ E++E E + E EE R + R E E
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR-----------EQEEER 359
Query: 63 FDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE- 121
+ R+ E++ E Q + EQ+ + E++L +E+ RR + +Q+ R E++
Sbjct: 360 REQQLRREQEEERREQQ----LRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQL 413
Query: 122 -RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
RE+Q + ++ R++EEE ++ + ++++ L +L + E+ Q R+
Sbjct: 414 RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYN 240
+++ E ++ + EE+ RE+ + + + + E+ + +LK+Q+ E L
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE--QRLKRQEEE-ERLQQ 530
Query: 241 RISHAQKFRK 250
R+ Q+ R+
Sbjct: 531 RLRSEQQLRR 540
Score = 55.5 bits (132), Expect = 5e-08
Identities = 55/216 (25%), Positives = 98/216 (45%), Gaps = 41/216 (18%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE+E + E+ E+ +E+E E E + + EE+ + R + E ER
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE------KRRRQERERQYRK 962
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKK--------EEEELVALKERIERRRSERAEQQRF 116
D ++ E+ LL + E+ KK +EEE + +ER +RRR E Q R
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022
Query: 117 RTEKERERQAKLAE--EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGK 174
+ E ++E + L E EK R +E E + R E++ ++++ EQ G+
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE----------------EQLLGE 1066
Query: 175 RQTGREMKVRILSERKKPLDIDYMGEEQLREKAQEL 210
+ R R++ L+ Y EE+L+++ ++L
Sbjct: 1067 ERETR---------RRQELERQYRKEEELQQEEEQL 1093
Score = 52.8 bits (125), Expect = 3e-07
Identities = 62/247 (25%), Positives = 114/247 (46%), Gaps = 44/247 (17%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPK-------- 54
++E Q EEE+ + EEE+ + AE + ER + PPL +
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 55 --------IPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKE-EEELVALKERIER 105
+PE E + R+ EK+L L+ + +R ++ +EE L+E ER
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 106 RRSE---RAEQQRFRTEKERERQ-----AKLA-EEKMRKE-------------EEEAKKR 143
RRS+ R ++ R++ E+ER+R+ AK A +E++RKE EE K+R
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 144 AEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE-MKVRILSERKKPLDIDYMGEEQ 202
++ ++ + + L + +KR +++ R+ K + L ++++ L +GEE
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL----LGEEP 978
Query: 203 LREKAQE 209
+ + QE
Sbjct: 979 EKRRRQE 985
Score = 51.6 bits (122), Expect = 7e-07
Identities = 65/252 (25%), Positives = 115/252 (45%), Gaps = 29/252 (11%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEE--ERPKPSRPVVPPLIPPKIPEG 58
+ + EEQ ++ + + EEE E+ E E+ R + R + + E
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 59 ERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKER----IERRRSERAEQQ 114
E+ D RK E++ Q L +++ +EEE+ V +ER +E + R E+
Sbjct: 1405 EQQLRQDRDRKFREEE----QQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Query: 115 R-FRTE----KERERQAKLAEEKMRK--EEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVK 167
R FR E +ERE Q +E+ RK EEE+ +R E D K ++ +L +
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE 1520
Query: 168 AE----QKRGKRQTGREMKVRIL---SERKKPLDIDYMGEEQLREKAQELSDWIHQLESE 220
+ Q+R ++ E ++R +R++ D + EEQLR++ +E QL +
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE-----QQLSRQ 1575
Query: 221 KFDLMAKLKQQK 232
+ D +L++QK
Sbjct: 1576 ERDRKFRLEEQK 1587
Score = 51.2 bits (121), Expect = 9e-07
Identities = 57/279 (20%), Positives = 122/279 (43%), Gaps = 47/279 (16%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE E Q E+ EEEE +E E + E E+ + R +++
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR------------------RQEWE 1017
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSER-AEQQRFRTEKERE 123
+RK+ E E Q L + ++R +E E +E +++ + E++ R +E E
Sbjct: 1018 RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077
Query: 124 RQAKLAEEKMRKEEEE------AKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQT 177
RQ + EE++++EEE+ K+R ++ ++ + + L + +KR +++
Sbjct: 1078 RQYR-KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 178 GREMK---------VRILSE-----RKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFD 223
R+ + ++L E R++ L+ Y EE+L+++ + QL E+ +
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE-------QLLREEQE 1189
Query: 224 LMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
+ ++++Y R Q++R + + +W+
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE 1228
Score = 50.8 bits (120), Expect = 1e-06
Identities = 58/238 (24%), Positives = 103/238 (43%), Gaps = 34/238 (14%)
Query: 5 EEQEYEEEQPEEEAAE--EEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVD 62
E++E E++ + E E E+EE E+ EPEEER + K E E
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL---------KSEEQEERR 643
Query: 63 FDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER 122
+ R++ E+ EQR K EEE L++R++R E +Q E++
Sbjct: 644 QQQLRREQQERR------------EQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 123 ERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFG-GYLVKAEQKRGKRQT---- 177
+ + ++ K R + + + +E DA++ KV S G + E+KR +R++
Sbjct: 692 QARERI---KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 178 ---GREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQK 232
R + + E+++ + EE+ Q LS E + L A+ +QQ+
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Score = 50.4 bits (119), Expect = 2e-06
Identities = 50/206 (24%), Positives = 94/206 (45%), Gaps = 38/206 (18%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE++ + + ++ EEE+ E+ E E+ R + R + E +R
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE-------ERKRRRHT 888
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERER 124
+ +++ L + Q L+ +EEEE + +ER +RRR E+ Q R E
Sbjct: 889 LYAKPALQEQLRKEQQLL--------QEEEEELQREEREKRRRQEQERQYR------EEE 934
Query: 125 QAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVR 184
Q + EE++ +EE E ++R E + + +K K Q++ ++ G E + R
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRK-------------DKKLQQKEEQLLGEEPEKR 981
Query: 185 ILSERKKPLDIDYMGEEQLREKAQEL 210
ER+K Y EE+L+++ ++L
Sbjct: 982 RRQEREK----KYREEEELQQEEEQL 1003
Score = 50.4 bits (119), Expect = 2e-06
Identities = 58/236 (24%), Positives = 104/236 (44%), Gaps = 45/236 (19%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
+ EEQ EE+ + E E + EE E E E+ L+ + R
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ------------LLGEERETRRR 1073
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKE-------------EEELVALKERIERRR 107
+ + +RK E E Q L + ++R++E EEE + +ER +RRR
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Query: 108 SERAEQQRFRTEKERERQAKLAE--EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYL 165
E Q R E ++E + L E EK R++E E + R E++ ++++ L
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE----------EQL 1183
Query: 166 VKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEK 221
++ EQ++ +++ R+ + +R+K +++ R++ Q SD Q E EK
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQK-------RKQRYRDEDQR-SDLKWQWEPEK 1231
Score = 50.4 bits (119), Expect = 2e-06
Identities = 55/256 (21%), Positives = 113/256 (44%), Gaps = 42/256 (16%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE++ E+ E+ +E E E E + + EE+ L+ + R + +
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREEEELQQEEEQ-----------LLGEERETRRRQELE 1077
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRK-------KEEEELVALKERIERRRSERAEQQRFR 117
+RK E E Q L + ++R+ +EEEEL +E++ R E+ +Q
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE 1137
Query: 118 TEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQT 177
+ E + + EE++ +EE E ++R E + + Y + E ++ + Q
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQ--------------YREEEELQQEEEQL 1183
Query: 178 GREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI-- 235
RE + + ER++ Y EE+L+ + ++ ++ E ++ DL + + +K
Sbjct: 1184 LREEQEKRRQERER----QYREEEELQRQKRKQR---YRDEDQRSDLKWQWEPEKENAVR 1236
Query: 236 -NVLYNRISHAQKFRK 250
N +Y + ++FR+
Sbjct: 1237 DNKVYCKGRENEQFRQ 1252
Score = 50.4 bits (119), Expect = 2e-06
Identities = 58/267 (21%), Positives = 122/267 (45%), Gaps = 30/267 (11%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVD 62
D + + EEEQ +E E++ E E E++ + R + E +++
Sbjct: 1664 DRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE------RKFLQEEQQLR 1717
Query: 63 FDDIHRKRMEKDLLELQTLIDVHFEQRKK----EEEELVALKERIERRRSE-----RAEQ 113
++ RK E++ L +T + Q + EEE+L +E + RR E R E+
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777
Query: 114 QRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRG 173
Q + +E++ +++ ++ K R+EE+ ++R E + ++ G Y + EQ +
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ-------RDGKYRWEEEQLQL 1830
Query: 174 KRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQ-- 231
+ Q E ++R +R+ + + +E+ R + QEL W + + + + KL+++
Sbjct: 1831 EEQ---EQRLRQERDRQYRAEEQFATQEKSRREEQEL--WQEEEQKRRQERERKLREEHI 1885
Query: 232 -KYEINVLYNRISHAQKFRKGAGKGRV 257
+ + +R K ++G G GR+
Sbjct: 1886 RRQQKEEQRHRQVGEIKSQEGKGHGRL 1912
Score = 50.1 bits (118), Expect = 2e-06
Identities = 66/255 (25%), Positives = 119/255 (46%), Gaps = 34/255 (13%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEA--PEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEG 58
+ + EEQ+ ++ + + EEE++ E E E +P R K E
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPER---------KFLEE 1520
Query: 59 ERVDFDDIHRK-RMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFR 117
E+ +HR+ R K L E Q L Q+++++ + +E E+ R ER EQQ R
Sbjct: 1521 EQ----QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE--EQLRQEREEQQLSR 1574
Query: 118 TEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQT 177
+ER+R+ +L E+K+R++E+E +K ED+ + ++ G ++ E+ R R+
Sbjct: 1575 --QERDRKFRLEEQKVRRQEQE-RKFMEDEQQLRR-------QEGQQQLRQERDRKFRED 1624
Query: 178 GREMKVRILSE-RKKPLDIDYMGEE-QLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
+ ++ R + ++ D ++ EE QLR QE + KF +L Q+ E
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRR--QEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 236 NVLYNRISHAQKFRK 250
+ R +KFR+
Sbjct: 1683 QL--RRQERDRKFRE 1695
Score = 50.1 bits (118), Expect = 2e-06
Identities = 59/242 (24%), Positives = 114/242 (47%), Gaps = 38/242 (15%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EEQ+ ++ E + E+E++ + E + +ER + R L + +
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQ-EGQQQLRQERDRKFREDEQLL--------QEREEQ 1634
Query: 65 DIHRKRMEKDLLELQTLIDV--------HFEQRK-KEEEELVALKERIERRRSER----- 110
+HR+ ++ LE + + H RK +EEE+L+ E + RR ER
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR 1694
Query: 111 AEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFG-GYLVKAE 169
E+Q+ R + ERER+ E+++R++E E K R E+ +++ + +++ E
Sbjct: 1695 EEEQQLRRQ-ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753
Query: 170 QKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLK 229
Q R +R+ E ++ R++ D + EEQLR++ +E QL S++ D + +
Sbjct: 1754 QLRPERE---EQQL-----RRQERDRKFREEEQLRQEREE-----QQLRSQESDRKFREE 1800
Query: 230 QQ 231
+Q
Sbjct: 1801 EQ 1802
Score = 45.1 bits (105), Expect = 6e-05
Identities = 56/242 (23%), Positives = 110/242 (45%), Gaps = 35/242 (14%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEER--------PKPSRPVVPPLIPPKIP 56
EEQE ++ E + EEEE ++ + E++R P+ V + K
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245
Query: 57 EGER---VDFDDIHRKRMEKDLLEL---QTLIDVHFEQRKKE-------EEELVALKERI 103
E E+ ++ + ++ ++DL L Q D E+R+ + EEE + +E+
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305
Query: 104 ERRRSERA---EQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAH 160
E +R +R E+Q R E+E +R+ + + K R+EE+ ++R E ++++
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE----RDRK 1361
Query: 161 FGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESE 220
F ++ Q++G++ E ++R +K ++ EEQ + + QE + Q
Sbjct: 1362 FREEELR-HQEQGRKFLEEEQRLRRQERERK-----FLKEEQ-QLRCQEREQQLRQDRDR 1414
Query: 221 KF 222
KF
Sbjct: 1415 KF 1416
Score = 43.1 bits (100), Expect = 2e-04
Identities = 50/226 (22%), Positives = 106/226 (46%), Gaps = 18/226 (7%)
Query: 6 EQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERV--DF 63
E+E E + ++EA + ++ EE + + E EE+ + K E E++ +
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET------DRKFREEEQLLQER 1348
Query: 64 DDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERE 123
++ +R E+D + + H EQ +K EE L+ R ER R E+Q+ R ++ +
Sbjct: 1349 EEQPLRRQERDRKFREEELR-HQEQGRKFLEEEQRLR-RQERERKFLKEEQQLRCQEREQ 1406
Query: 124 RQAKLAEEKMRKEEEEAKKRAED-DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMK 182
+ + + K R+EE++ ++ D ++++ +L + +Q R +R +
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 183 VRILSER------KKPLDIDYMGEE-QLREKAQELSDWIHQLESEK 221
++L ER ++ D ++ EE QLR + ++ +L S++
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Score = 42.4 bits (98), Expect = 4e-04
Identities = 53/256 (20%), Positives = 106/256 (41%), Gaps = 58/256 (22%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
E + E+E+ E+ + EE E + + + EE+ + + + E+ +
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL----------RREQQERR 655
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEE---EELVALKERIERR--------------- 106
+ KR E++ Q L H E+R+++E EE +ERI+ R
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 107 ------RSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED------------DA 148
R + E QR R E+E +R+ + +E + ++EE +++ E+ +
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 149 KKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKV---------RILSERKKPLDIDYMG 199
K ++ + A + Q R + + RE + R R++ ++ ++
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 200 EE---QLREKAQELSD 212
EE Q RE+AQ+L +
Sbjct: 836 EEEQLQRRERAQQLQE 851
Score = 38.1 bits (87), Expect = 0.008
Identities = 47/241 (19%), Positives = 103/241 (42%), Gaps = 44/241 (18%)
Query: 10 EEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRK 69
+ Q E++ E + E EP ++R + R ++ EGE ++
Sbjct: 112 DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER---------ELAEGEE---QSEKQE 159
Query: 70 RMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLA 129
R+E+ R++ +EEL ++ + R RAE+++ ++ K E +
Sbjct: 160 RLEQ-------------RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206
Query: 130 EEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSER 189
EE++R+ E +R + K+++ F + E++ KR+T +L +
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVF---QEEEEKEWRKRET-------VLRKE 256
Query: 190 KKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFR 249
++ L + E Q + + QE + + +LE + +L++++ E R+ Q+ R
Sbjct: 257 EEKLQEE---EPQRQRELQEEEEQLRKLERQ------ELRRERQEEEQQQQRLRREQQLR 307
Query: 250 K 250
+
Sbjct: 308 R 308
Score = 32.3 bits (72), Expect = 0.43
Identities = 29/139 (20%), Positives = 66/139 (47%), Gaps = 17/139 (12%)
Query: 100 KERIERRRSERAEQQRF--------------RTEKERERQAKLAEEKMRKEEEEAKKRAE 145
KE + + R + +Q+RF R +K +E++ +LAE + + E++E ++ +
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 146 DDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSE---RKKPLDIDYMGEEQ 202
+ +++ +AE+++ + G E + E R++ L++ G E+
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 203 LREKAQELSDWIHQLESEK 221
+++ +E D + Q E EK
Sbjct: 226 KQQQRRERQDRVFQEEEEK 244
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 64.3 bits (155), Expect = 1e-10
Identities = 50/232 (21%), Positives = 118/232 (50%), Gaps = 18/232 (7%)
Query: 6 EQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDD 65
EQE + + EE+ E+EE+ ++ E + E EE+ K + + E+V +
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE--------QEEQVQKQE 247
Query: 66 IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQ 125
++ E+ + + + + EQ +++EE+++ KE+ E+ ++++ R E+E Q
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR---EQEEQ 304
Query: 126 AKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHF---GGYLVKAEQKRGKRQ---TGR 179
+ EE+MR++EE+ +++ E K+++ + + K E++ G+++ +
Sbjct: 305 MREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364
Query: 180 EMKVRILSER-KKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQ 230
E +VR E+ +K + EEQ+R++ +++ + Q+ +K + + +Q
Sbjct: 365 EEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQ 416
Score = 62.4 bits (150), Expect = 4e-10
Identities = 48/203 (23%), Positives = 99/203 (48%), Gaps = 16/203 (7%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
++QE + ++ EE+ ++EE+ E+ E + E EE+ K + E++
Sbjct: 244 QKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQE--EQTGEQEEQMREQ 301
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE--- 121
+ + E+ + E + + EQ K+EE++ KE++ ++ + +Q+ E+E
Sbjct: 302 EEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361
Query: 122 --RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
+E Q + EE+MRK+EE+ +K+ E K+++ + G EQK R+
Sbjct: 362 QKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG------EQKEQMREQEE 415
Query: 180 EMKVRILSERKKPLDIDYMGEEQ 202
+M + RK+ ++MGE++
Sbjct: 416 QMGEQKEQMRKQE---EHMGEQK 435
Score = 52.0 bits (123), Expect = 5e-07
Identities = 50/237 (21%), Positives = 110/237 (46%), Gaps = 28/237 (11%)
Query: 6 EQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDD 65
EQE + + E + E+E + E+ V E E + + V + EG+ V +
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ-VREQE 177
Query: 66 IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQ 125
+ E + E + + Q ++EE++ +E+++++ + EQ E Q
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ---------EEQ 228
Query: 126 AKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRI 185
+ EE+M ++EE+ +K+ E K+++ + + EQ R + + RE + ++
Sbjct: 229 MRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK----------QEEQMREQEEQMREQEEQM 278
Query: 186 LSERKKPLDIDYMG--EEQLREKAQELSDWIHQLES------EKFDLMAKLKQQKYE 234
L ++++ + G EEQ+RE+ +++ + Q+ E+ + M K ++Q +E
Sbjct: 279 LKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE 335
Score = 52.0 bits (123), Expect = 5e-07
Identities = 38/147 (25%), Positives = 75/147 (51%), Gaps = 6/147 (4%)
Query: 4 TEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDF 63
T EQE + + EE+ E+EE+ E+ E + E EE+ K + + E++
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQK-EQMWEQKEQMWK 349
Query: 64 DDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERI---ERRRSERAEQQRFRTEK 120
+ E+ + + + + EQ +K+EE++ +E++ E + E+ EQ + E+
Sbjct: 350 QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQ 409
Query: 121 ERERQAKLAEEK--MRKEEEEAKKRAE 145
RE++ ++ E+K MRK+EE ++ E
Sbjct: 410 MREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 49.3 bits (116), Expect = 3e-06
Identities = 35/170 (20%), Positives = 86/170 (50%), Gaps = 16/170 (9%)
Query: 1 MSDTEEQ---EYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPE 57
M + EEQ + E+ + EE+ E+EE+ E+ E + E EE+ + + +
Sbjct: 271 MREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMRE--------Q 322
Query: 58 GERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSE---RAEQQ 114
E++ + ++ + E + + EQ ++EE++ +E++ ++ + + EQ
Sbjct: 323 EEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382
Query: 115 RFRTEKERERQAKLAEEK--MRKEEEEAKKRAEDDAKKKKVLSNMGAHFG 162
R + E+ R+++ ++ E+K M +++E+ +++ E ++K+ + H G
Sbjct: 383 RKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMG 432
Score = 35.4 bits (80), Expect = 0.051
Identities = 40/230 (17%), Positives = 105/230 (45%), Gaps = 30/230 (13%)
Query: 6 EQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDD 65
EQE + + E + E+E + E+ V E E + + V + EG+
Sbjct: 56 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV-------REQEGQ------ 102
Query: 66 IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE---R 122
+ E + E + + Q +++E ++ + ++ + + EQ+ E+E R
Sbjct: 103 --VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 160
Query: 123 ERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMK 182
E++ ++ E++ + E+E + R E + + ++ MG G + + E++ G+++ + +
Sbjct: 161 EQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQMGEQ-EGQMGEQEEQMGEQEEQMQKQ 218
Query: 183 VRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQK 232
+ E+ EEQ+R++ +++ + Q++ ++ + + +Q +
Sbjct: 219 EEQMGEQ----------EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMR 258
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 61.2 bits (147), Expect = 9e-10
Identities = 69/260 (26%), Positives = 114/260 (43%), Gaps = 64/260 (24%)
Query: 3 DTEEQEYEEEQP--------------EEEAAEEEEE-----------APEEPEPVAEPEE 37
D E++E EEE+P EE+ E +EE + EEP+ EE
Sbjct: 187 DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ----EE 242
Query: 38 ERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELV 97
ER + S +I E+++ +D R E+ LE + + EQ KK +E
Sbjct: 243 EREQGS---------DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERA 293
Query: 98 ALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNM 157
++ + ER ++ E+ RE + + AEE+ R +EEE KRA ++ ++
Sbjct: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEE--KRAAEERQR------- 344
Query: 158 GAHFGGYLVKAEQKRG--KRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIH 215
+K E+KR +RQ +E + R ER++ EE+ + K +E
Sbjct: 345 --------IKEEEKRAAEERQRIKEEEKRAAEERQRA-----RAEEEEKAKVEE-QKRNK 390
Query: 216 QLESEKFDLM-AKLKQQKYE 234
QLE +K + K+K +K E
Sbjct: 391 QLEEKKHAMQETKIKGEKVE 410
Score = 52.8 bits (125), Expect = 3e-07
Identities = 58/240 (24%), Positives = 109/240 (45%), Gaps = 32/240 (13%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
MS Q EE +EE E+ + E + E ++ER + R R
Sbjct: 226 MSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAER--------------AR 271
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
++ ++ R + E+D + + D E+ + E EE A +ER ERR +E E+ R ++
Sbjct: 272 LEAEERERIKAEQD----KKIAD---ERARIEAEEKAAAQER-ERREAEERERMREEEKR 323
Query: 121 ERERQAKLAEEKMRKEEE-----EAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKR 175
E + ++ EE+ R EE E +KRA ++ ++ K A E+++ K
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKV 383
Query: 176 QTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLM-AKLKQQKYE 234
+ + K L E+K + + E++ +K + W+++ ++++ L A LK+Q E
Sbjct: 384 EEQKRNKQ--LEEKKHAMQETKIKGEKVEQKIE--GKWVNEKKAQEDKLQTAVLKKQGEE 439
Score = 50.4 bits (119), Expect = 2e-06
Identities = 32/104 (30%), Positives = 62/104 (59%), Gaps = 12/104 (11%)
Query: 53 PKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEE---ELVALKERIERRRSE 109
P++ G+R++ ++ R+R E + E + L ++K++E EL LK++ E RR
Sbjct: 528 PQVEAGKRLE--ELRRRRGETESEEFEKL-------KQKQQEAALELEELKKKREERRKV 578
Query: 110 RAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKV 153
E+++ R ++E +R+ + EEK R +EE ++RAE K++K+
Sbjct: 579 LEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKM 622
Score = 41.6 bits (96), Expect = 7e-04
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 7/104 (6%)
Query: 57 EGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKK-EEEELVALKERIERRRSERAEQQR 115
E E +F+ + +K+ E LEL+ L E+RK EEEE +E +R+ E E++R
Sbjct: 545 ETESEEFEKLKQKQQEA-ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR 603
Query: 116 FRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGA 159
+ E ER R+A+ AE++ + E+ DD K K + G+
Sbjct: 604 LKEEIER-RRAEAAEKRQKMPED----GLSDDKKPFKCFTPKGS 642
Score = 41.2 bits (95), Expect = 0.001
Identities = 54/262 (20%), Positives = 109/262 (41%), Gaps = 34/262 (12%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
E Q +EE E+ AAEE + A E E A+ EE++ + +GE+V+
Sbjct: 355 ERQRIKEE--EKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQK 412
Query: 65 D----IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEK 120
++ K+ ++D L+ L E+ K + + L+E + E + ++ + +K
Sbjct: 413 IEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDK 472
Query: 121 ERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGY---------------- 164
E + + K ++ + E + E K K N + GG
Sbjct: 473 EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEA 532
Query: 165 ---LVKAEQKRGK---------RQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSD 212
L + ++RG+ +Q +E + + +KK + + EE+ + + QE +D
Sbjct: 533 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEAD 592
Query: 213 WIHQLESEKFDLMAKLKQQKYE 234
+ E EK L ++++++ E
Sbjct: 593 RKLREEEEKRRLKEEIERRRAE 614
Score = 38.1 bits (87), Expect = 0.008
Identities = 35/160 (21%), Positives = 76/160 (47%), Gaps = 17/160 (10%)
Query: 87 EQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED 146
E R+++ EE+ ERI +R++ E++ R + R RQ +L + K+EEE+ + D
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQ----KQEEESLGQVTD 64
Query: 147 -----------DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDI 195
D + K +N G ++ +R+ R+ +++ ER+K D
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVE-GDDEAAFLERLARREERRQKRLQEALERQKEFD- 122
Query: 196 DYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
+ + L ++ + + + E+ + + ++ +Q++YEI
Sbjct: 123 PTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEI 162
Score = 37.7 bits (86), Expect = 0.010
Identities = 58/255 (22%), Positives = 108/255 (42%), Gaps = 27/255 (10%)
Query: 2 SDTEEQEYEEEQ---PEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEG 58
++ E+ EEE+ E + +EEE+ E + EE+R R + E
Sbjct: 311 AEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 370
Query: 59 ERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRT 118
+R ++ + ++E+ Q H Q K + E V K + ++A++ + +T
Sbjct: 371 QRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQT 430
Query: 119 -----------EKERERQAKLAEEK--MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYL 165
K + ++ KL E+K +KEE + +K +D K++V S M G
Sbjct: 431 AVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 490
Query: 166 VKAEQKRGKRQTGR-EMKVRILSERKKPLDIDYMGEE-----QLREKAQELSDWIHQLES 219
VK++ G+ T + + S +D E + ++ +EL + ES
Sbjct: 491 VKSQ--NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES 548
Query: 220 EKFDLMAKLKQQKYE 234
E+F+ KLKQ++ E
Sbjct: 549 EEFE---KLKQKQQE 560
Score = 29.3 bits (64), Expect = 3.6
Identities = 35/163 (21%), Positives = 66/163 (40%), Gaps = 22/163 (13%)
Query: 1 MSDTEEQEYEEEQPEEEA----AEEEEEAPEEP---EPVAEPEEERPKPSRPVVPPL--I 51
++D E + P+EEA + E +E E +A EE R K + +
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 52 PPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERA 111
P I + + +RM+ D E +T ++EE+ + +ER E +E
Sbjct: 122 DPTITDASL----SLPSRRMQNDTAENETT---------EKEEKSESRQERYEIEETETV 168
Query: 112 EQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 154
+ + + + K +++ +EEEE KR + +V+
Sbjct: 169 TKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVM 211
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 60.8 bits (146), Expect = 1e-09
Identities = 54/213 (25%), Positives = 105/213 (49%), Gaps = 29/213 (13%)
Query: 4 TEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDF 63
T ++ E+++ E E + EEE E PE EP P + R DF
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTL------------RRDF 356
Query: 64 DDIHRKRMEK-DLLELQTLIDVHFEQRKKEEEEL--VALKERIERRRSERAEQQRFRTEK 120
+ ++ E+ + L Q L+ EQ+ +E+EE L ER +R ++ +++R ++
Sbjct: 357 LRLQQENKERSEALRRQQLLQ---EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
Query: 121 ERERQAKLAEEK-MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
RER+A+ +E+ R+ E+E K+R E+ +++K +AE+++ + + +
Sbjct: 414 RREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR--------RAEEEKRRVEREQ 465
Query: 180 EMKVRILSERKKPLDIDYMGEEQLREKAQELSD 212
E R L E ++ L++ + ++ L+E+A L D
Sbjct: 466 EYIRRQLEEEQRHLEV--LQQQLLQEQAMLLHD 496
Score = 32.7 bits (73), Expect = 0.33
Identities = 43/221 (19%), Positives = 86/221 (38%), Gaps = 65/221 (29%)
Query: 79 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE------------------- 119
Q L + E + + LK+ I+R R +R E+ E
Sbjct: 282 QLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPS 341
Query: 120 ----------------------KER----ERQAKLAEEKMRKEEE-------EAKKRAED 146
KER RQ L E+++R++EE E +KR E
Sbjct: 342 SIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ 401
Query: 147 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID-YMGEEQLRE 205
++++ L + ++ +RQ RE + R E+++ +++ EE+ R
Sbjct: 402 QKEQRRRLEEQ---------QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR 452
Query: 206 KAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 246
+A+E ++E E+ + +L++++ + VL ++ Q
Sbjct: 453 RAEEEK---RRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 60.8 bits (146), Expect = 1e-09
Identities = 54/213 (25%), Positives = 105/213 (49%), Gaps = 29/213 (13%)
Query: 4 TEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDF 63
T ++ E+++ E E + EEE E PE EP P + R DF
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTL------------RRDF 356
Query: 64 DDIHRKRMEK-DLLELQTLIDVHFEQRKKEEEEL--VALKERIERRRSERAEQQRFRTEK 120
+ ++ E+ + L Q L+ EQ+ +E+EE L ER +R ++ +++R ++
Sbjct: 357 LRLQQENKERSEALRRQQLLQ---EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
Query: 121 ERERQAKLAEEK-MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
RER+A+ +E+ R+ E+E K+R E+ +++K +AE+++ + + +
Sbjct: 414 RREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR--------RAEEEKRRVEREQ 465
Query: 180 EMKVRILSERKKPLDIDYMGEEQLREKAQELSD 212
E R L E ++ L++ + ++ L+E+A L D
Sbjct: 466 EYIRRQLEEEQRHLEV--LQQQLLQEQAMLLHD 496
Score = 32.7 bits (73), Expect = 0.33
Identities = 43/221 (19%), Positives = 86/221 (38%), Gaps = 65/221 (29%)
Query: 79 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE------------------- 119
Q L + E + + LK+ I+R R +R E+ E
Sbjct: 282 QLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPS 341
Query: 120 ----------------------KER----ERQAKLAEEKMRKEEE-------EAKKRAED 146
KER RQ L E+++R++EE E +KR E
Sbjct: 342 SIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ 401
Query: 147 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID-YMGEEQLRE 205
++++ L + ++ +RQ RE + R E+++ +++ EE+ R
Sbjct: 402 QKEQRRRLEEQ---------QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR 452
Query: 206 KAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 246
+A+E ++E E+ + +L++++ + VL ++ Q
Sbjct: 453 RAEEEK---RRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 60.5 bits (145), Expect = 1e-09
Identities = 57/234 (24%), Positives = 113/234 (48%), Gaps = 30/234 (12%)
Query: 4 TEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDF 63
T ++ E+++ E E + EEE E PE EP P + R DF
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTL------------RRDF 356
Query: 64 DDIHRKRMEK-DLLELQTLIDVHFEQRKKEEEEL--VALKERIERRRSERAEQQRFRTEK 120
+ ++ E+ + L Q L+ EQ+ +E+EE L ER +R ++ +++R ++
Sbjct: 357 LRLQQENKERSEALRRQQLLQ---EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
Query: 121 ERERQAKLAEEK-MRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
RER+A+ +E+ R+ E+E K+R E+ +++K +AE+++ + + +
Sbjct: 414 RREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR--------RAEEEKRRVEREQ 465
Query: 180 EMKVRILSERKKPLDIDYMGEEQLREKAQELS-DWIHQLESEKFDLMAKLKQQK 232
E R L E ++ L++ + ++ L+E+A L W E + + + + QQ+
Sbjct: 466 EYIRRQLEEEQRHLEV--LQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQE 517
Score = 32.7 bits (73), Expect = 0.33
Identities = 43/221 (19%), Positives = 86/221 (38%), Gaps = 65/221 (29%)
Query: 79 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE------------------- 119
Q L + E + + LK+ I+R R +R E+ E
Sbjct: 282 QLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPS 341
Query: 120 ----------------------KER----ERQAKLAEEKMRKEEE-------EAKKRAED 146
KER RQ L E+++R++EE E +KR E
Sbjct: 342 SIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQ 401
Query: 147 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDID-YMGEEQLRE 205
++++ L + ++ +RQ RE + R E+++ +++ EE+ R
Sbjct: 402 QKEQRRRLEEQ---------QRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERR 452
Query: 206 KAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQ 246
+A+E ++E E+ + +L++++ + VL ++ Q
Sbjct: 453 RAEEEK---RRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 60.1 bits (144), Expect = 2e-09
Identities = 54/246 (21%), Positives = 122/246 (49%), Gaps = 30/246 (12%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
++QE + + EE+ E EE+ E+ E + E EE K+ E + ++
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEEKIREQEE----------------KMRRQEEMMWE 327
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFR-TEKERE 123
+ R +++++ + E++ +E EE + +E+I + +R E+++ R EK +E
Sbjct: 328 KEEKMRRQEEMMWEK-------EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 380
Query: 124 RQAKL--AEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREM 181
++AK+ EEK+R++EE+ +++ E ++++ MG + E+ + + + R
Sbjct: 381 QEAKMWRQEEKIREQEEKIREQEEMMQEQEE---KMGEQEEKMWEQEEEMQEQEEKMRRQ 437
Query: 182 KVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNR 241
+ +I + KK + + EQ E QE + + + E + + AK+++Q+ ++ +
Sbjct: 438 EEKIREQEKKIREQEEKIREQ-EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEK 496
Query: 242 ISHAQK 247
I +K
Sbjct: 497 IREQEK 502
Score = 56.6 bits (135), Expect = 2e-08
Identities = 52/231 (22%), Positives = 110/231 (47%), Gaps = 32/231 (13%)
Query: 7 QEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDI 66
+E EE+ E+E E+EE +E E + E E+ + + ++
Sbjct: 347 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK---------------------- 384
Query: 67 HRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERI---ERRRSERAEQQRFRTEKERE 123
R E+ + E + I E +++EE++ +E++ E E+ E+ R + EK RE
Sbjct: 385 -MWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIRE 443
Query: 124 RQAKL--AEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREM 181
++ K+ EEK+R++EE +++ E +++ + A + E+ R + + RE
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKM---QEQEEKMRRQEEKIREQ 500
Query: 182 KVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQK 232
+ +I + +K + + M +EQ EK E + + + E + + K+++Q+
Sbjct: 501 EKKIREQEEKIREQEEMMQEQ-EEKMWEQEEKMCEQEEKMQEQEEKMRRQE 550
Score = 51.6 bits (122), Expect = 7e-07
Identities = 45/199 (22%), Positives = 97/199 (48%), Gaps = 23/199 (11%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
+EQE + + EE+ E+EE+ E+ E + E EE+ + + + E +
Sbjct: 379 QEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM--------WEQEEEMQEQ 430
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERI----------ERRRSERAEQQ 114
+ +R E+ + E + I E+ +++EE + +E++ E + E+ E+
Sbjct: 431 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKM 490
Query: 115 RFRTEKERERQAKL--AEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKR 172
R + EK RE++ K+ EEK+R++EE +++ E ++++ + + E+ R
Sbjct: 491 RRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM---QEQEEKMR 547
Query: 173 GKRQTGREMKVRILSERKK 191
+ + RE +VR+ + +K
Sbjct: 548 RQEEKMREQEVRLRQQEEK 566
Score = 50.4 bits (119), Expect = 2e-06
Identities = 49/239 (20%), Positives = 113/239 (47%), Gaps = 34/239 (14%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
M + E+ +EE+ +EE E+E +E E +EE+ + KI E E
Sbjct: 353 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE--------EKIREQEE 404
Query: 61 VDFDDIHRK-RMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTE 119
+ + + E+ + E + + E+ +++EE++ +++I + + EQ+ E
Sbjct: 405 MMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 464
Query: 120 KER---ERQAKLAEEKMRKEEEEAKKRAEDD---AKKKKVLSNMGAHFGGYLVKAEQKRG 173
+E E++ K+ E++ + +E+E K R +++ ++KK+ + E+ R
Sbjct: 465 QEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE-----------QEEKIRE 513
Query: 174 KRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQK 232
+ + +E + ++ + +K M E++ EK QE + + + E + + +L+QQ+
Sbjct: 514 QEEMMQEQEEKMWEQEEK------MCEQE--EKMQEQEEKMRRQEEKMREQEVRLRQQE 564
Score = 47.4 bits (111), Expect = 1e-05
Identities = 34/143 (23%), Positives = 75/143 (52%), Gaps = 6/143 (4%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGE-RV 61
+ +EQE + + EE+ E+E++ E+ E + E EE + + K+ E E ++
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ--EGKMCEQEAKM 483
Query: 62 DFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERI---ERRRSERAEQQRFRT 118
+ +R E+ + E + I E+ +++EE + +E++ E + E+ E+ + +
Sbjct: 484 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 543
Query: 119 EKERERQAKLAEEKMRKEEEEAK 141
EK R ++ K+ E+++R ++E K
Sbjct: 544 EKMRRQEEKMREQEVRLRQQEEK 566
Score = 37.0 bits (84), Expect = 0.017
Identities = 45/200 (22%), Positives = 99/200 (49%), Gaps = 31/200 (15%)
Query: 60 RVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVA-LKERIER-----RRSERAEQ 113
+++ ++ RK LL Q + + KE + + A L+ ++E R +++ E+
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288
Query: 114 QRFRTEKE-RERQAKL---------AEEKMRKEEE-----EAKKRAEDD---AKKKKVLS 155
+ +R E++ +ER+ K+ EEKMR++EE E K R +++ K++K+
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 156 -NMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWI 214
H + + E+KR + + RE + R E K + EE++RE+ +++ +
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM-----WRQEEKIREQEEKIREQ- 402
Query: 215 HQLESEKFDLMAKLKQQKYE 234
++ E+ + M + +++ +E
Sbjct: 403 EEMMQEQEEKMGEQEEKMWE 422
Score = 31.6 bits (70), Expect = 0.73
Identities = 29/148 (19%), Positives = 69/148 (46%), Gaps = 8/148 (5%)
Query: 92 EEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKK 151
E+E+ + + + RR A+ Q R ++ + ++A + A K+ E +A+
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMA----LYYSQHAVKQLEGEARDL 151
Query: 152 KVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY----MGEEQLREKA 207
+ F G L +A ++ + + L++ + L ++ + +E+L+EK
Sbjct: 152 ISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 211
Query: 208 QELSDWIHQLESEKFDLMAKLKQQKYEI 235
+L + + +ESEK ++ +K+ K ++
Sbjct: 212 AKLQEKLQLVESEKSEIQLNVKELKRKL 239
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 59.7 bits (143), Expect = 3e-09
Identities = 37/122 (30%), Positives = 67/122 (54%), Gaps = 9/122 (7%)
Query: 87 EQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAED 146
+Q+++E E L ++E +E+ R R E ++ R ++E ER+ KL E RK+EEE +K+ ED
Sbjct: 917 KQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKRED 976
Query: 147 DAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREK 206
D K+ + A L + +++ ++Q E + R +R+ L I E + ++
Sbjct: 977 DEKR------IQAEVEAQLARQKEEESQQQAVLEQERR---DRELALRIAQSEAELISDE 1027
Query: 207 AQ 208
AQ
Sbjct: 1028 AQ 1029
Score = 47.0 bits (110), Expect = 2e-05
Identities = 45/182 (24%), Positives = 80/182 (43%), Gaps = 29/182 (15%)
Query: 73 KDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEK 132
K + Q I ++ K EEL++ ++ +++ E +R + E E+ER+ + +EK
Sbjct: 886 KSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEK 945
Query: 133 MR-KEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKK 191
R KEEEE + + E +AK+K + E++R KR+ + RI +E
Sbjct: 946 RRRKEEEERRMKLEMEAKRK---------------QEEEERKKREDDEK---RIQAE--- 984
Query: 192 PLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKG 251
E QL + +E S LE E+ D L+ + E ++ + R+
Sbjct: 985 -------VEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRRN 1037
Query: 252 AG 253
G
Sbjct: 1038 DG 1039
Score = 42.4 bits (98), Expect = 4e-04
Identities = 23/77 (29%), Positives = 46/77 (59%), Gaps = 12/77 (15%)
Query: 68 RKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAK 127
RKR E+D E+R+++EEE +K +E +R + E+++ R + E+ QA+
Sbjct: 937 RKRREED------------EKRRRKEEEERRMKLEMEAKRKQEEEERKKREDDEKRIQAE 984
Query: 128 LAEEKMRKEEEEAKKRA 144
+ + R++EEE++++A
Sbjct: 985 VEAQLARQKEEESQQQA 1001
Score = 38.1 bits (87), Expect = 0.008
Identities = 22/91 (24%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 66 IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQ 125
+ +K+ +++ E I E+ +K EE + + E R + E + R ++E ER+
Sbjct: 913 LQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERK 972
Query: 126 AKLAEEKMRKEEEEAK--KRAEDDAKKKKVL 154
+ +EK + E EA+ ++ E++++++ VL
Sbjct: 973 KREDDEKRIQAEVEAQLARQKEEESQQQAVL 1003
Score = 34.7 bits (78), Expect = 0.087
Identities = 37/153 (24%), Positives = 66/153 (43%), Gaps = 26/153 (16%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
+E+E E + +E E+E + EE E EEE + + E +R +
Sbjct: 919 QEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM----------EAKRKQEE 968
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERR------RSERAEQQRFRT 118
+ RK+ E D +Q ++ ++K+EE + A+ E+ ERR R ++E +
Sbjct: 969 E-ERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQ-ERRDRELALRIAQSEAELISD 1026
Query: 119 EKERE--------RQAKLAEEKMRKEEEEAKKR 143
E + + + K+ E+M KE E R
Sbjct: 1027 EAQADLALRRNDGTRPKMTPEQMAKEMSEFLSR 1059
>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
Length = 273
Score = 58.9 bits (141), Expect = 4e-09
Identities = 57/194 (29%), Positives = 85/194 (43%), Gaps = 41/194 (21%)
Query: 2 SDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERV 61
++ E Q +Q EE EEE A E VA+ EE + + + + ++ E +R+
Sbjct: 108 AEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRI 167
Query: 62 DFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE 121
MEK LLE E ++ + EL A K R E R++R E +R E
Sbjct: 168 ---------MEKQLLE---------ELERQRQAELAAQKAREEEERAKREELERILEENN 209
Query: 122 R---ERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTG 178
R E QAKLAEE++R EE+ K E +K EQ+R +RQ
Sbjct: 210 RKIAEAQAKLAEEQLRIVEEQRKIHEE-------------------RMKLEQER-QRQQK 249
Query: 179 REMKVRILSERKKP 192
E K+ + + +P
Sbjct: 250 EEQKIILGKGKSRP 263
Score = 47.0 bits (110), Expect = 2e-05
Identities = 51/183 (27%), Positives = 85/183 (46%), Gaps = 30/183 (16%)
Query: 87 EQRKKEEEELVALKERIERRRSERAEQQRFRTEKER---ERQAKLAEEKMRKEEEEAKK- 142
E++K+EEEE A ER + R + E++ E R E AK EE++ K ++E ++
Sbjct: 97 EKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIERE 156
Query: 143 --RAEDDAKK---KKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 197
R ++AK+ K++L + L + + + + RE RIL E + +
Sbjct: 157 VLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQ 216
Query: 198 --MGEEQLR--EKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAG 253
+ EEQLR E+ +++ + +LE E + +QQK E QK G G
Sbjct: 217 AKLAEEQLRIVEEQRKIHEERMKLEQE------RQRQQKEE-----------QKIILGKG 259
Query: 254 KGR 256
K R
Sbjct: 260 KSR 262
Score = 35.0 bits (79), Expect = 0.066
Identities = 40/163 (24%), Positives = 77/163 (47%), Gaps = 18/163 (11%)
Query: 88 QRKKEEEELVALKERIE-------RRRSERAEQQRFRTEK--ERERQAKLAEEKMRKE-- 136
+R+++ E + +RI+ +R S +Q+R EK E ERQ K+ ++++ ++
Sbjct: 67 RRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLI 126
Query: 137 EEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSE----RKKP 192
EEE +R E + K+V + ++ E R + R M+ ++L E R+
Sbjct: 127 EEETARRVE-ELVAKRVEEELEKRKDE--IEREVLRRVEEAKRIMEKQLLEELERQRQAE 183
Query: 193 LDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
L EE+ R K +EL + + + + AKL +++ I
Sbjct: 184 LAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRI 226
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 57.8 bits (138), Expect = 1e-08
Identities = 57/253 (22%), Positives = 125/253 (49%), Gaps = 33/253 (13%)
Query: 7 QEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDI 66
+E EE+ E+E E+EE +E E + E E+ + + ++ KI E E +
Sbjct: 380 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE---EKIREQEEKIREQ- 435
Query: 67 HRKRMEKDLLELQTLIDVHFEQRKKEEEEL------VALKERIERRRSERAEQQRFRTEK 120
K+M + ++ + E++++E+EE+ + +E I R++ + EQ++ R ++
Sbjct: 436 -EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 121 E----------------RERQAKL--AEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFG 162
E RE++ K+ EEK+R++EE+ +++ E ++++++ G
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554
Query: 163 GYLVK-AEQKRGKRQTG--REMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLES 219
K EQ++ +RQ RE + +I +++K + + EQ EK +E + + + E
Sbjct: 555 EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQ-EEKIREQEEMMQEQEE 613
Query: 220 EKFDLMAKLKQQK 232
+ ++ K+ +Q+
Sbjct: 614 KMWEQEEKMCEQE 626
Score = 56.2 bits (134), Expect = 3e-08
Identities = 54/233 (23%), Positives = 116/233 (49%), Gaps = 26/233 (11%)
Query: 5 EEQEYEEEQ-PEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDF 63
EE+ +E+E+ EEE +E+EE + E + E EE + K+ E E++
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE----------KMHEQEKIRK 492
Query: 64 DDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER- 122
+ R E+ + + + I E+ ++EE++ +E+I + + EQ+ E+E
Sbjct: 493 QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEK 552
Query: 123 --ERQAKLAE-EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
E++ K+ E EKMR++EE+ +++ E ++K+ + + E+ R + + +
Sbjct: 553 MGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI---WEQEEKIREQEEMMQ 609
Query: 180 EMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQK 232
E + ++ + +K M E++ EK QE + + + E + ++ +L+QQ+
Sbjct: 610 EQEEKMWEQEEK------MCEQE--EKMQEQEEKMRRQEEKMWEQEVRLRQQE 654
Score = 47.8 bits (112), Expect = 1e-05
Identities = 44/232 (18%), Positives = 112/232 (48%), Gaps = 31/232 (13%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
++QE + + EE+ E EE+ E+ E + E EE+ + K+ E + ++
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEE---------KMRRQEEMMWE 346
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERER 124
+ R +++++ + E+ ++ EE + +E+I + EQ++ R ++E+ +
Sbjct: 347 KEEKMRRQEEMMWEKE------EKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 400
Query: 125 QAKLAEEKMRKEEEEAKK-RAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKV 183
+ + E+ +++E+EAK R E+ ++++ ++ ++K+ RQ + +
Sbjct: 401 EEEKIREQEKRQEQEAKMWRQEEKIREQE-----------EKIREQEKKMWRQEEKIHEQ 449
Query: 184 RILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
+ E +K + + M ++ + + QE W + EK K+++Q+ ++
Sbjct: 450 EKIREEEKRQEQEEMWRQEEKIREQE-EIW---RQKEKMHEQEKIRKQEEKV 497
Score = 43.9 bits (102), Expect = 1e-04
Identities = 39/174 (22%), Positives = 81/174 (46%), Gaps = 11/174 (6%)
Query: 7 QEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDI 66
QE + EE+ E+EE+ + E + E EE+ + KI E E + +
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE---------KIREQEEMMQEQE 550
Query: 67 HRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQA 126
+ +++ ++ Q + E+ +++EE++ KE+I + + EQ+ E+E Q
Sbjct: 551 EKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Query: 127 KLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
+ EEKM ++EE+ ++ E ++++ + V+ Q+ K Q +E
Sbjct: 611 Q--EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 30.0 bits (66), Expect = 2.1
Identities = 36/178 (20%), Positives = 82/178 (46%), Gaps = 15/178 (8%)
Query: 60 RVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVA-LKERIERRRS-ERAEQQRFR 117
+++ ++ RK LL Q + + KE + + A L+ ++E R QQ+
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 300
Query: 118 TEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQT 177
+E + + EEK++++EE+ +++ E ++++ + + E K +
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR----------QEEMMWEKEEK 350
Query: 178 GREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
R + + + +K ++ M E+ EK +EL + +H E EK + +Q++ +I
Sbjct: 351 MRRQEEMMWEKEEKMRRLEEMMWEK-EEKIRELEEKMH--EQEKIREQEEKRQEEEKI 405
Score = 29.6 bits (65), Expect = 2.8
Identities = 21/102 (20%), Positives = 50/102 (49%), Gaps = 4/102 (3%)
Query: 138 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 197
+ A K+ E +A+ + F G L +A ++ + + L++ + L ++
Sbjct: 150 QHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLEL 209
Query: 198 ----MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEI 235
+ +E+L+EK +L + + +ESEK ++ +K+ K ++
Sbjct: 210 YRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL 251
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 56.2 bits (134), Expect = 3e-08
Identities = 44/161 (27%), Positives = 80/161 (49%), Gaps = 18/161 (11%)
Query: 79 QTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEE 138
Q + + + +KE + ++A ++ IE R+ ER E + EKE Q + +K+RK EE
Sbjct: 551 QLAVTAYLKNSRKEHQRILARRQTIEERK-ERLESLNIQREKEELEQREAELQKVRKAEE 609
Query: 139 EAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSER---KKPLDI 195
E ++ + +K+++L E ++ K++T RE +I K DI
Sbjct: 610 ERLRQEAKEREKERILQ-------------EHEQIKKKTVRERLEQIKKTELGAKAFKDI 656
Query: 196 DYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEIN 236
D E+L + ++ + QLE EK +L +LK Q+ +I+
Sbjct: 657 DIEDLEEL-DPDFIMAKQVEQLEKEKKELQERLKNQEKKID 696
Score = 45.4 bits (106), Expect = 5e-05
Identities = 46/157 (29%), Positives = 79/157 (50%), Gaps = 21/157 (13%)
Query: 67 HRKRMEKDL-------LELQTLIDVHFEQRKKEEEELVALKE--RIERRRSERAEQQR-- 115
H+ RM + L + L+ +E++ K+ EE +A + R+E R+ +R E++R
Sbjct: 746 HKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRIT 805
Query: 116 FRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKR 175
+ EKE E Q + AEE+M KE EE ++RAE AK+++ L L + E+K+ +R
Sbjct: 806 YYREKEEEEQRR-AEEQMLKEREE-RERAE-RAKREEELREYQERV-KKLEEVERKKRQR 861
Query: 176 QTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSD 212
+ E + R E ++ +G+ L K D
Sbjct: 862 ELEIEERERRREEERR------LGDSSLSRKDSRWGD 892
Score = 37.7 bits (86), Expect = 0.010
Identities = 44/167 (26%), Positives = 78/167 (46%), Gaps = 26/167 (15%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERP------KPSRPVVPPLIPPK 54
+ D + E +EE+ E E+A E ++ E+R K +R V K
Sbjct: 719 IKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSV---YEEK 775
Query: 55 IPEGERVDFDDIH-----RKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSE 109
+ + E ++ H RKR K+ + + E++++ EE++ LKER ER E
Sbjct: 776 LKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQM--LKEREER---E 830
Query: 110 RAE----QQRFRTEKERERQAKLAEEKMRKEE---EEAKKRAEDDAK 149
RAE ++ R +ER ++ + E K R+ E EE ++R E++ +
Sbjct: 831 RAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERR 877
Score = 36.2 bits (82), Expect = 0.030
Identities = 37/169 (21%), Positives = 70/169 (41%), Gaps = 24/169 (14%)
Query: 1 MSDTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGER 60
+ + + Q EE + +EEEE E + + EER + R E E
Sbjct: 791 LEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAK---------REEEL 841
Query: 61 VDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELV--ALKERIERRRSER-------- 110
++ + +K E + + Q +++ +R++EEE + + R + R +R
Sbjct: 842 REYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRK 901
Query: 111 -----AEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 154
+E +R EKE R E++ + +EE +R DD ++ L
Sbjct: 902 GPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSL 950
Score = 33.9 bits (76), Expect = 0.15
Identities = 47/251 (18%), Positives = 111/251 (44%), Gaps = 33/251 (13%)
Query: 10 EEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRK 69
E+E+ E+ AE ++ E E + + +ER K + E E++ + +
Sbjct: 590 EKEELEQREAELQKVRKAEEERLRQEAKEREKER----------ILQEHEQIKKKTVRER 639
Query: 70 --RMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKER----E 123
+++K L + D+ E ++ + + + K+ + + ++ Q+R + ++++ E
Sbjct: 640 LEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFE 699
Query: 124 RQAKLAEEKMRK---EEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGRE 180
R +L E + K EE+ K + ++++ ++ M L + + K + R
Sbjct: 700 RAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTM------QLEREKALEHKNRMSRM 753
Query: 181 MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIH-QLESEKFDLMAKLKQQKYEINVLY 239
++ R L + + EE+L++ + L++ H +LE K +Q+K E + Y
Sbjct: 754 LEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERK-------RQRKEERRITY 806
Query: 240 NRISHAQKFRK 250
R ++ R+
Sbjct: 807 YREKEEEEQRR 817
Score = 33.5 bits (75), Expect = 0.19
Identities = 38/178 (21%), Positives = 74/178 (41%), Gaps = 30/178 (16%)
Query: 4 TEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVP---------PLIPPK 54
+EE+E++ E+ + ++ EE ++PE + E + + R P P
Sbjct: 1198 SEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESS 1257
Query: 55 I--PEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRK-----KEEEELVALKERIERRR 107
R D D R+R D +L+ D+ ++ + + E E V+ R + R+
Sbjct: 1258 SWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRK 1317
Query: 108 SERAEQQ---------RFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSN 156
+R E++ ++ER+R + + E+E+A RAE D + + N
Sbjct: 1318 DDRVEERDPPRRVPPPALSRDRERDR-----DREREGEKEKASWRAEKDRESLRRTKN 1370
Score = 33.1 bits (74), Expect = 0.25
Identities = 30/137 (21%), Positives = 60/137 (43%), Gaps = 8/137 (5%)
Query: 15 EEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKD 74
EE+ + EE EE E + + K R + K E +R + + ++R E++
Sbjct: 773 EEKLKQFEERLAEERHNRLEERKRQRKEERRIT--YYREKEEEEQRRAEEQMLKEREERE 830
Query: 75 LLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMR 134
E E+ +E +E V E +ER++ +R E + E+ RE + +L + +
Sbjct: 831 RAERAKR-----EEELREYQERVKKLEEVERKKRQR-ELEIEERERRREEERRLGDSSLS 884
Query: 135 KEEEEAKKRAEDDAKKK 151
+++ R + +K
Sbjct: 885 RKDSRWGDRDSEGTWRK 901
Score = 28.9 bits (63), Expect = 4.8
Identities = 31/132 (23%), Positives = 57/132 (43%), Gaps = 6/132 (4%)
Query: 87 EQRKKEEEELVALKE-RIERRRSERAEQQRFRTEKERERQAKLAEEKMRKE----EEEAK 141
E+ K EE +E R R E++R R ++RE K E + +E E+
Sbjct: 1180 EKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRF 1239
Query: 142 KRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEE 201
+R D+ ++ + + + + ++ R R+ R+ + R L ER+ D
Sbjct: 1240 RRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDR-RDLRERRDLRDDRDRRGP 1298
Query: 202 QLREKAQELSDW 213
LR + +E+S W
Sbjct: 1299 PLRSEREEVSSW 1310
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 77/153 (50%), Gaps = 6/153 (3%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVA-EPEEERPKPSRPVVPPLIPPKIPEGERV 61
+ E E ++ EEE +EE ++ E + + EEER + + + +R
Sbjct: 734 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQRE 793
Query: 62 DFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE 121
+ R+R E++ + + + E+R++EEEE +E + ++ E A+ R +E
Sbjct: 794 QEIALRRQREEEERQQQEEALR-RLEERRREEEERRKQEELLRKQEEEAAKWAR----EE 848
Query: 122 RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 154
E Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 849 EEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 881
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 78 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 137
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 138 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 197
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 777 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 828
Query: 198 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 250
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 829 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 877
Score = 45.4 bits (106), Expect = 5e-05
Identities = 47/193 (24%), Positives = 82/193 (42%), Gaps = 32/193 (16%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE ++E+ EEE + EE E +EE + R L R +
Sbjct: 753 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---------RRQRE 803
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTE 119
+ R++ E+ L L+ E+RK+EE EE A R E R E+ R R E
Sbjct: 804 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 863
Query: 120 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
+E R +R EEEE K++ + ++K+++ + +Q+ R+ +
Sbjct: 864 EEAAR--------LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQ 905
Query: 180 EMKVRILSERKKP 192
+ + + L++ K P
Sbjct: 906 QQQQQQLAQMKLP 918
Score = 38.5 bits (88), Expect = 0.006
Identities = 45/199 (22%), Positives = 81/199 (40%), Gaps = 61/199 (30%)
Query: 6 EQEYEEEQPEEEAAE-------EEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEG 58
++E EE Q +EEA EEEE ++ E + + EEE K +R E
Sbjct: 801 QREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWARE-----------EE 849
Query: 59 ERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRT 118
E + +R RME++ L+ E+RK++E E+ KE + +R+ ++ +R +
Sbjct: 850 EAQRRLEENRLRMEEEAARLRH----EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ 905
Query: 119 EK---------------------------------------ERERQAKLAEEKMRKEEEE 139
++ E ER+ +L EE+ R++ E
Sbjct: 906 QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 965
Query: 140 AKKRAEDDAKKKKVLSNMG 158
K + ++++ LS G
Sbjct: 966 MKALQQQQQQQQQKLSGWG 984
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 77/153 (50%), Gaps = 6/153 (3%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVA-EPEEERPKPSRPVVPPLIPPKIPEGERV 61
+ E E ++ EEE +EE ++ E + + EEER + + + +R
Sbjct: 761 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQRE 820
Query: 62 DFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE 121
+ R+R E++ + + + E+R++EEEE +E + ++ E A+ R +E
Sbjct: 821 QEIALRRQREEEERQQQEEALR-RLEERRREEEERRKQEELLRKQEEEAAKWAR----EE 875
Query: 122 RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 154
E Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 876 EEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 908
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 78 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 137
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 138 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 197
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 804 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 855
Query: 198 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 250
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 856 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 904
Score = 45.4 bits (106), Expect = 5e-05
Identities = 47/193 (24%), Positives = 82/193 (42%), Gaps = 32/193 (16%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE ++E+ EEE + EE E +EE + R L R +
Sbjct: 780 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---------RRQRE 830
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTE 119
+ R++ E+ L L+ E+RK+EE EE A R E R E+ R R E
Sbjct: 831 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 890
Query: 120 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
+E R +R EEEE K++ + ++K+++ + +Q+ R+ +
Sbjct: 891 EEAAR--------LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQ 932
Query: 180 EMKVRILSERKKP 192
+ + + L++ K P
Sbjct: 933 QQQQQQLAQMKLP 945
Score = 38.5 bits (88), Expect = 0.006
Identities = 45/199 (22%), Positives = 81/199 (40%), Gaps = 61/199 (30%)
Query: 6 EQEYEEEQPEEEAAE-------EEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEG 58
++E EE Q +EEA EEEE ++ E + + EEE K +R E
Sbjct: 828 QREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWARE-----------EE 876
Query: 59 ERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRT 118
E + +R RME++ L+ E+RK++E E+ KE + +R+ ++ +R +
Sbjct: 877 EAQRRLEENRLRMEEEAARLRH----EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ 932
Query: 119 EK---------------------------------------ERERQAKLAEEKMRKEEEE 139
++ E ER+ +L EE+ R++ E
Sbjct: 933 QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 992
Query: 140 AKKRAEDDAKKKKVLSNMG 158
K + ++++ LS G
Sbjct: 993 MKALQQQQQQQQQKLSGWG 1011
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 77/153 (50%), Gaps = 6/153 (3%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVA-EPEEERPKPSRPVVPPLIPPKIPEGERV 61
+ E E ++ EEE +EE ++ E + + EEER + + + +R
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQRE 799
Query: 62 DFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE 121
+ R+R E++ + + + E+R++EEEE +E + ++ E A+ R +E
Sbjct: 800 QEIALRRQREEEERQQQEEALR-RLEERRREEEERRKQEELLRKQEEEAAKWAR----EE 854
Query: 122 RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 154
E Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 855 EEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 887
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 78 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 137
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 138 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 197
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 783 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 834
Query: 198 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 250
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 835 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 883
Score = 45.4 bits (106), Expect = 5e-05
Identities = 47/193 (24%), Positives = 82/193 (42%), Gaps = 32/193 (16%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE ++E+ EEE + EE E +EE + R L R +
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---------RRQRE 809
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTE 119
+ R++ E+ L L+ E+RK+EE EE A R E R E+ R R E
Sbjct: 810 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 869
Query: 120 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
+E R +R EEEE K++ + ++K+++ + +Q+ R+ +
Sbjct: 870 EEAAR--------LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQ 911
Query: 180 EMKVRILSERKKP 192
+ + + L++ K P
Sbjct: 912 QQQQQQLAQMKLP 924
Score = 38.5 bits (88), Expect = 0.006
Identities = 45/199 (22%), Positives = 81/199 (40%), Gaps = 61/199 (30%)
Query: 6 EQEYEEEQPEEEAAE-------EEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEG 58
++E EE Q +EEA EEEE ++ E + + EEE K +R E
Sbjct: 807 QREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWARE-----------EE 855
Query: 59 ERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRT 118
E + +R RME++ L+ E+RK++E E+ KE + +R+ ++ +R +
Sbjct: 856 EAQRRLEENRLRMEEEAARLRH----EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ 911
Query: 119 EK---------------------------------------ERERQAKLAEEKMRKEEEE 139
++ E ER+ +L EE+ R++ E
Sbjct: 912 QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 971
Query: 140 AKKRAEDDAKKKKVLSNMG 158
K + ++++ LS G
Sbjct: 972 MKALQQQQQQQQQKLSGWG 990
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 77/153 (50%), Gaps = 6/153 (3%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVA-EPEEERPKPSRPVVPPLIPPKIPEGERV 61
+ E E ++ EEE +EE ++ E + + EEER + + + +R
Sbjct: 740 ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQRE 799
Query: 62 DFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKE 121
+ R+R E++ + + + E+R++EEEE +E + ++ E A+ R +E
Sbjct: 800 QEIALRRQREEEERQQQEEALR-RLEERRREEEERRKQEELLRKQEEEAAKWAR----EE 854
Query: 122 RERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVL 154
E Q +L E ++R EEE A+ R E++ +K+K L
Sbjct: 855 EEAQRRLEENRLRMEEEAARLRHEEEERKRKEL 887
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/173 (22%), Positives = 82/173 (47%), Gaps = 12/173 (6%)
Query: 78 LQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEE 137
L+ L + + K E+E + R +R ER Q+ R ++E + + EE+ R+EE
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 138 EEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDY 197
EE +R +++A +++ + Q+ + + +E +R L ER++ +
Sbjct: 783 EELARRKQEEALRRQREQEIALR--------RQREEEERQQQEEALRRLEERRREEEERR 834
Query: 198 MGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 250
EE LR++ +E + W + E + +L++ + + R+ H ++ RK
Sbjct: 835 KQEELLRKQEEEAAKWAREEE----EAQRRLEENRLRMEEEAARLRHEEEERK 883
Score = 45.4 bits (106), Expect = 5e-05
Identities = 47/193 (24%), Positives = 82/193 (42%), Gaps = 32/193 (16%)
Query: 5 EEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFD 64
EE ++E+ EEE + EE E +EE + R L R +
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---------RRQRE 809
Query: 65 DIHRKRMEKDLLELQTLIDVHFEQRKKEE-----EELVALKERIERRRSERAEQQRFRTE 119
+ R++ E+ L L+ E+RK+EE EE A R E R E+ R R E
Sbjct: 810 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 869
Query: 120 KERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGR 179
+E R +R EEEE K++ + ++K+++ + +Q+ R+ +
Sbjct: 870 EEAAR--------LRHEEEERKRKELEVQRQKELMRQ----------RQQQQEALRRLQQ 911
Query: 180 EMKVRILSERKKP 192
+ + + L++ K P
Sbjct: 912 QQQQQQLAQMKLP 924
Score = 38.5 bits (88), Expect = 0.006
Identities = 45/199 (22%), Positives = 81/199 (40%), Gaps = 61/199 (30%)
Query: 6 EQEYEEEQPEEEAAE-------EEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEG 58
++E EE Q +EEA EEEE ++ E + + EEE K +R E
Sbjct: 807 QREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWARE-----------EE 855
Query: 59 ERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRT 118
E + +R RME++ L+ E+RK++E E+ KE + +R+ ++ +R +
Sbjct: 856 EAQRRLEENRLRMEEEAARLRH----EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQ 911
Query: 119 EK---------------------------------------ERERQAKLAEEKMRKEEEE 139
++ E ER+ +L EE+ R++ E
Sbjct: 912 QQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQREL 971
Query: 140 AKKRAEDDAKKKKVLSNMG 158
K + ++++ LS G
Sbjct: 972 MKALQQQQQQQQQKLSGWG 990
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 56.2 bits (134), Expect = 3e-08
Identities = 55/247 (22%), Positives = 119/247 (48%), Gaps = 20/247 (8%)
Query: 3 DTEEQEYEEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVD 62
+ E + E+E+ E E+E+E E + + E E+ER + E E +
Sbjct: 568 ERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIK 627
Query: 63 FDDIHRKRMEKDLLELQTLIDVHFEQRKKEEE--ELVALKERIERRRSERAEQQRFRTEK 120
I K+ ++ E++ L+D++ K++ + +L+A +++ + + ++ + +K
Sbjct: 628 QLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDK 687
Query: 121 ERERQAKLAEE----KMRKEEEE----AKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKR 172
E++ K+A+E K+R EE+ KK A +++ +LS M + EQ
Sbjct: 688 EKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNI 747
Query: 173 GKRQTGRE---MKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESE---KFDLMA 226
Q RE +++SER K I + L+E+ +EL+D + L+++ + ++
Sbjct: 748 RLMQQLREKDDANFKLMSERIKSNQI----HKLLKEEKEELADQVLTLKTQVDAQLQVVR 803
Query: 227 KLKQQKY 233
KL+++++
Sbjct: 804 KLEEKEH 810
Score = 49.3 bits (116), Expect = 3e-06
Identities = 41/155 (26%), Positives = 71/155 (45%), Gaps = 24/155 (15%)
Query: 103 IERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFG 162
I+ +R E E++R R EKERER+ + +EK R+ E++ K +E + K
Sbjct: 560 IKSKRDEE-ERERERREKEREREREREKEKEREREKQKLKESEKERDSAK---------- 608
Query: 163 GYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESE-- 220
++++GK GR+ + I+ K L I+ ++ +++ + L D E
Sbjct: 609 ------DKEKGKHDDGRKKEAEII----KQLKIELKKAQESQKEMKLLLDMYRSAPKEQR 658
Query: 221 -KFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGK 254
K LMA K+ K E+ L R+ + K K
Sbjct: 659 DKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENK 693
Score = 47.8 bits (112), Expect = 1e-05
Identities = 46/205 (22%), Positives = 100/205 (48%), Gaps = 32/205 (15%)
Query: 56 PEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQR 115
P+ E + K ++D E+++ D +R++ E+E +ER + + ER +Q+
Sbjct: 538 PDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKL 597
Query: 116 FRTEKER----ERQAKLAEEKMRKEEEEAK------KRAEDDAKKKKVLSNMGAHFGGYL 165
+EKER +++ ++ +KE E K K+A++ K+ K+L +M Y
Sbjct: 598 KESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDM------YR 651
Query: 166 VKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIHQLESEKF--- 222
+++R K Q + +E+K ++ E LR++ ++L D + E++K
Sbjct: 652 SAPKEQRDKVQL-------MAAEKKSKAEL-----EDLRQRLKDLED-KEKKENKKMADE 698
Query: 223 DLMAKLKQQKYEINVLYNRISHAQK 247
D + K++ + +I L +++ A++
Sbjct: 699 DALRKIRAVEEQIEYLQKKLAMAKQ 723
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 56.2 bits (134), Expect = 3e-08
Identities = 54/177 (30%), Positives = 80/177 (45%), Gaps = 28/177 (15%)
Query: 4 TEEQEYEEEQPEEEAAEEEEE-----APEEPE-PVAEPEEERPKPSRPVVPPL--IPPKI 55
T E E E PEE++ + PE P A P++ P PL I K
Sbjct: 266 TPESEVLESFPEEDSVLSHSSLSSPSSTSSPEGPPAPPKQHSSTSPFPTSTPLRRITKKF 325
Query: 56 PEGE------RVDFDD--------IHRKRMEKDLLELQTLIDVHFEQRKKEEEELVALKE 101
+G R+ D + +R EK+ L+ + ++KKEEE+ + KE
Sbjct: 326 VKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKE 385
Query: 102 RIERRRS---ERAEQQRFRTEKERERQAKL---AEEKMRKEEEEAKKRAEDDAKKKK 152
R E+R E+AE+QR + E+ +ERQ L EEK +KEEE+ + E K +K
Sbjct: 386 RREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEK 442
Score = 39.3 bits (90), Expect = 0.004
Identities = 29/108 (26%), Positives = 58/108 (53%), Gaps = 16/108 (14%)
Query: 10 EEEQPEEEAAEEEEEAPEEPEPVAEPEEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRK 69
E+E+ +EEA +EEA ++ E E +E+ + R E+ + + ++
Sbjct: 356 EKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKR--------------EKDEKEKAEKQ 401
Query: 70 RMEKDLL-ELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRF 116
R++++ E Q ++ E+++K+EEE L+E +R ++E+AE RF
Sbjct: 402 RLKEERRKERQEALEAKLEEKRKKEEEK-RLREEEKRIKAEKAEITRF 448
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.129 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,558,402
Number of Sequences: 37866
Number of extensions: 706895
Number of successful extensions: 36446
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 991
Number of HSP's successfully gapped in prelim test: 1074
Number of HSP's that attempted gapping in prelim test: 10130
Number of HSP's gapped (non-prelim): 12493
length of query: 262
length of database: 18,247,518
effective HSP length: 100
effective length of query: 162
effective length of database: 14,460,918
effective search space: 2342668716
effective search space used: 2342668716
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.