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Search of human proteins with 112807234
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112807234 G protein-coupled receptor, family C, group 6,
member A [Homo sapiens]
(926 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112807234 G protein-coupled receptor, family C, group 6, memb... 1874 0.0
gi|37577159 calcium-sensing receptor [Homo sapiens] 501 e-142
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 392 e-109
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 366 e-101
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 360 3e-99
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 300 3e-81
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 283 5e-76
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 280 4e-75
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 272 9e-73
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 255 1e-67
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 254 2e-67
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 249 8e-66
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 249 8e-66
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 243 8e-64
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 239 9e-63
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 230 4e-60
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 230 4e-60
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 196 1e-49
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 180 6e-45
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 91 4e-18
gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] 65 2e-10
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 52 3e-06
gi|8923705 G protein-coupled receptor, family C, group 5, member... 45 3e-04
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 45 4e-04
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 45 4e-04
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 45 4e-04
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 44 0.001
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 44 0.001
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 44 0.001
gi|7706451 G protein-coupled receptor, family C, group 5, member... 39 0.029
>gi|112807234 G protein-coupled receptor, family C, group 6, member
A [Homo sapiens]
Length = 926
Score = 1874 bits (4855), Expect = 0.0
Identities = 926/926 (100%), Positives = 926/926 (100%)
Query: 1 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI 60
MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI
Sbjct: 1 MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQI 60
Query: 61 QECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKF 120
QECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKF
Sbjct: 61 QECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKF 120
Query: 121 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI 180
NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI
Sbjct: 121 NCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKI 180
Query: 181 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA 240
RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA
Sbjct: 181 RFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIA 240
Query: 241 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI 300
FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI
Sbjct: 241 FKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWI 300
Query: 301 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH 360
ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH
Sbjct: 301 ASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMH 360
Query: 361 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF 420
LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF
Sbjct: 361 LSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVF 420
Query: 421 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK 480
ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK
Sbjct: 421 ALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWK 480
Query: 481 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI 540
EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI
Sbjct: 481 EINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI 540
Query: 541 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL 600
CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL
Sbjct: 541 CCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLIL 600
Query: 601 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK 660
SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK
Sbjct: 601 SLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCK 660
Query: 661 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT 720
TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT
Sbjct: 661 TRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICT 720
Query: 721 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE 780
LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE
Sbjct: 721 LWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNE 780
Query: 781 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK 840
AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK
Sbjct: 781 AKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICK 840
Query: 841 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA 900
QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA
Sbjct: 841 QEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQA 900
Query: 901 QAFAHICRENATSVSKTLPRKRMSSI 926
QAFAHICRENATSVSKTLPRKRMSSI
Sbjct: 901 QAFAHICRENATSVSKTLPRKRMSSI 926
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 501 bits (1291), Expect = e-142
Identities = 316/965 (32%), Positives = 508/965 (52%), Gaps = 65/965 (6%)
Query: 10 CFVIILAT-SQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSE-DSPRRPQIQECVGFE 67
C+V++ T PD A G II+GGLF IH + + + D RP+ EC+ +
Sbjct: 7 CWVLLALTWHTSAYGPDQ--RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN 64
Query: 68 ISVFLQTLAMIHSIEMINNS-TLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRET 126
F AMI +IE IN+S LLP + LGY I+DTC V+ A+ ATL F+++
Sbjct: 65 FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLN 124
Query: 127 VEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFL 186
++ C+ S ++P AV+G+ S ++ AV+ +L L +PQV Y S++ +LS+K +F SFL
Sbjct: 125 LDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFL 184
Query: 187 RTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLP 246
RT+P+D HQ AMA +I+ WNW+G I DDDYGR + F +AE ++CI F E++
Sbjct: 185 RTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELIS 244
Query: 247 AFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNI-NKMWIASDNW 305
+ + I+ + ++I + VIVVF + L + + NI K+W+AS+ W
Sbjct: 245 QYSDEEEIQ-----HVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAW 299
Query: 306 STATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSAC- 364
++++ I +G +GFA + G I F FL+ +H S + E+ C
Sbjct: 300 ASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCH 359
Query: 365 ------------AYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLI 412
+++ + S F++S + A++ + N DY +
Sbjct: 360 LQEGAKGPLPVDTFLRGHEESGDRFSNS--STAFRPLCTGDENISSVETPYIDYTHLRIS 417
Query: 413 HSIQLAVFALGYAIRD---------LCQARDCQNPNAFQPWELLGVLKNVTFTDGW-NSF 462
+++ LAV+++ +A++D L C + + W++L L+++ FT+
Sbjct: 418 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQV 477
Query: 463 HFDAHGDLNTGYDVVLW--KEINGHMTVTKMAEYDL---QNDVFIIPDQETKNEFRNLKQ 517
FD GDL Y ++ W +G + ++ Y++ + + I +++ + +
Sbjct: 478 TFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREV 537
Query: 518 IQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRST 577
S CS++C G K + CC+EC CP+ Y+++TD C C + W+ T
Sbjct: 538 PFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPD-DFWSNENHT 596
Query: 578 MCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVIL 637
C KE+E+L+W + I L + ++LGI V +F + NTP+VK++ + Y++L
Sbjct: 597 SCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKAT-NRELSYLLL 655
Query: 638 LCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAF--SFDPKLQ 695
F+S+ FFIGEPQD+TC+ RQ FG+SF LCISCIL K+ ++LL F
Sbjct: 656 FSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFH 715
Query: 696 KFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSL-PRVIILECEEGSILAFGT 754
+ L L++F CT +Q+VIC +WL A P+ N L +I + C EGS++A G
Sbjct: 716 RKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGF 775
Query: 755 MLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPA 812
++GY +LA ICF FAFK + EN+NEAKFITF MLI+FI WI+FIP YA+T+GK+V A
Sbjct: 776 LIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSA 835
Query: 813 VEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLD 872
VE+I IL +++G+L C F K Y+I+ K NT ++ S ++H+ A +
Sbjct: 836 VEVIAILAASFGLLACIFFNKIYIILFKPSRNT---IEEVRCSTAAHAFKVAARATLRRS 892
Query: 873 SMS-------GNVTMTNPSSSGKSAT------WQKSKDLQAQAFAHICRENATSVSKTLP 919
++S G T + PSSS S + Q + Q Q A + ++ TLP
Sbjct: 893 NVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLA-LTQQEQQQQPLTLP 951
Query: 920 RKRMS 924
+++ S
Sbjct: 952 QQQRS 956
>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
Length = 852
Score = 392 bits (1008), Expect = e-109
Identities = 256/836 (30%), Positives = 420/836 (50%), Gaps = 57/836 (6%)
Query: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINN-STLLPG 92
G ++GGLF + E + S RP C F + L LAM ++E INN S LLPG
Sbjct: 33 GDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPG 92
Query: 93 VKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEIT 152
++LGY+++DTC+E VAM +L FL+K SR+ + C+Y+ Y PRV AVIG SE+
Sbjct: 93 LRLGYDLFDTCSEPVVAMKPSLMFLAKAG-SRDIAAY-CNYTQYQPRVLAVIGPHSSELA 150
Query: 153 MAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIG 212
M + + LMPQV Y ++ E+LS + FPSF RTVPSD Q+ A A L+Q+ GWNW+
Sbjct: 151 MVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVA 210
Query: 213 IITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVN 272
+ +DD+YGR L+ F A A +CIA + ++P +D++ ++ L + + ++ V
Sbjct: 211 ALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVLHQ-VNQSSVQ 269
Query: 273 VIVVFLRQFHVFDLFNKAIEMNIN-KMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRG 331
V+++F LFN +I ++ K+W+AS+ W T+ + +P + ++G V+GF R
Sbjct: 270 VVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGA 329
Query: 332 NISSFHSFLQNLHLLPSDSH--KLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKAN 389
+ F +++ L +D L E L + CI
Sbjct: 330 QLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCI------------- 376
Query: 390 KAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDL------CQARDCQNPNAFQP 443
++N GL H +V+A Y++ C A C + +P
Sbjct: 377 -------TLQN------VSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKP 423
Query: 444 WELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFII 503
W+LL + N+TF G FD+ G+++ YD+ LW +V ++ + N
Sbjct: 424 WQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWV---WQGSVPRLHDVGRFNGSLRT 480
Query: 504 PDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCL 563
+ + + ++ S+CS++C GQ+++ + H CCY+C +C Y D C
Sbjct: 481 ERLKIRWHTSDNQKPVSRCSRQCQEGQVRR-VKGFHSCCYDCVDCEAGSYRQNPDDIACT 539
Query: 564 LCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPV 623
C + W+P RST CF + +L W + +LLL+L L + VL +F + ++P+
Sbjct: 540 FC-GQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPL 598
Query: 624 VKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLK 683
V++SGG C+ L+C L S F G+P C +Q + + T C+S + ++ +
Sbjct: 599 VQASGGPLACFG-LVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAE 657
Query: 684 IL----LAFSFDPKLQKFLKCLYRP--ILIIFTCTGIQVVICTLWLIFAAPTVEVN-VSL 736
I L S+ +L CL P L++ ++V +CT +L+ P V + L
Sbjct: 658 IFVESELPLSWADRLS---GCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHML 714
Query: 737 PRVIILECEEGSILAFGTMLGYIAILAFICFI--FAFKGKYENYNEAKFITFGMLIYFIA 794
P ++ C S ++FG A LAF+CF+ F + + YN A+ +TF ML YFI
Sbjct: 715 PTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGRYNRARGLTFAMLAYFIT 774
Query: 795 WITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFL 850
W++F+P+ A PAV++ +L+ GIL +P+CY+++ + +NT FL
Sbjct: 775 WVSFVPLLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFL 830
>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
Length = 841
Score = 366 bits (939), Expect = e-101
Identities = 243/850 (28%), Positives = 410/850 (48%), Gaps = 50/850 (5%)
Query: 21 CQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHS 80
C + + T PG ++ GLF +H L P F + AM
Sbjct: 23 CHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLG 82
Query: 81 IEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139
+E INNST LLP + LGY++YD C++ + + ATLR LS + +E + D Y P
Sbjct: 83 VEEINNSTALLPNITLGYQLYDVCSD-SANVYATLRVLSL--PGQHHIELQGDLLHYSPT 139
Query: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAM 199
V AVIG + + +L+ L+P + Y +++E LS K ++PSFLRT+P+D +Q++ M
Sbjct: 140 VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199
Query: 200 AHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLP--AFLSDNTIEVR 257
L+QK GW WI ++ + DDYG+L + QA +CIAFK+++P A + D ++
Sbjct: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQC- 258
Query: 258 INRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNIN-KMWIASDNWSTATKITTIPN 316
L + + +A V+VVF + F + N+ K+W+AS+ W+ + IT +P
Sbjct: 259 ----LMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPG 314
Query: 317 VKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCI 376
+++IG V+G A ++ + +F + + + H+ S C+ + Q
Sbjct: 315 IQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKG----SWCSSNQLCRECQAF 370
Query: 377 FNHSQRTL-AYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDL--CQAR 433
H+ L A+ + A ++ AV+A+ + + L C +
Sbjct: 371 MAHTMPKLKAFSMSSA---------------------YNAYRAVYAVAHGLHQLLGCASG 409
Query: 434 DCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAE 493
C + PW+LL + V F ++ F+ + D + Y+++ W T T +
Sbjct: 410 ACSRGRVY-PWQLLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGS 468
Query: 494 YDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHY 553
I + + + ++ + +S CS +C G + T H CC+EC C +
Sbjct: 469 STWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHH-CCFECVPCGAGTF 527
Query: 554 TNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGI 613
N++D+ C C K WAP S CF + V +L + + +LL + L ++ +L
Sbjct: 528 LNKSDLYRCQPCG-KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAG 586
Query: 614 IFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLC 673
+F +L+TPVV+S+GG R+C+++L S F GEP C RQ +F + FT+
Sbjct: 587 LFAWHLDTPVVRSAGG-RLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIF 645
Query: 674 ISCILTKSLKILLAFSFDPKLQKFLKCLYRPI---LIIFTCTGIQVVICTLWLIFAAPTV 730
+SC+ +S ++++ F F K+ F + L + + Q++IC WL+ P
Sbjct: 646 LSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLP 705
Query: 731 EVNVS-LPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFG 787
P +++LEC E + L F Y +L+ F ++ GK ENYNEAK +TF
Sbjct: 706 AREYQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFS 765
Query: 788 MLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKS 847
+L F++WI F + GKY+PA ++ L S F+PKCYVI+C+ ++N+
Sbjct: 766 LLFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTE 825
Query: 848 AFLKMIYSYS 857
F I Y+
Sbjct: 826 HFQASIQDYT 835
>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
Length = 839
Score = 360 bits (924), Expect = 3e-99
Identities = 255/867 (29%), Positives = 421/867 (48%), Gaps = 63/867 (7%)
Query: 11 FVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISV 70
F ++ ++P + D ++ PG ++GGLF++H M Q+ C +E+ V
Sbjct: 12 FFLLWVLAEPAENSDFYL----PGDYLLGGLFSLHANMKGIVHL-NFLQVPMCKEYEVKV 66
Query: 71 FLQTL--AMIHSIEMINN-STLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETV 127
L AM ++E INN S+LLPGV LGYEI D C ++ + L FL+ + +
Sbjct: 67 IGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCY-ISNNVQPVLYFLAHED---NLL 122
Query: 128 EFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLR 187
+ DYS+Y+ RV AVIG SE M V+ L+L L+PQ+ Y + ++ L DK+RFP+ LR
Sbjct: 123 PIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLR 182
Query: 188 TVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPA 247
T PS H I+AM L+ WNWI ++ + D YGR + ++CIAF+E LP
Sbjct: 183 TTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPT 242
Query: 248 FLSDNTIEVRINRTLKKIILEAQ---VNVIVVFLRQFHVFDLFNKAIEMNI-NKMWIASD 303
+ + + L I+ + Q V+VVF ++ FN+ + N +WIAS+
Sbjct: 243 LQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASE 302
Query: 304 NWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSA 363
+W+ + + ++ +G +G + I F F + P L ++
Sbjct: 303 SWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFRE---WGPQAGPPPLSR-----TS 354
Query: 364 CAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALG 423
+Y + + C+ N + N ++R + +++S+ AV+A+
Sbjct: 355 QSYTCNQECDNCL------------NATLSFNTILR------LSGERVVYSVYSAVYAVA 396
Query: 424 YAIRDL--CQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKE 481
+A+ L C C PW+LL + V FT + FD GD+ ++V W+
Sbjct: 397 HALHSLLGCDKSTC-TKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQW 455
Query: 482 INGHMTVTKMAE-YDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHI 540
+A Y LQ + I D + S CSK C GQ KK H+
Sbjct: 456 DRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIP--MSMCSKRCQSGQKKKPV-GIHV 512
Query: 541 CCYECQNCPENHYTNQT-DMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLI 599
CC+EC +C + N T D C C N W+ T CF++++ +L W+++ I + +
Sbjct: 513 CCFECIDCLPGTFLNHTEDEYECQACPN-NEWSYQSETSCFKRQLVFLEWHEAPTIAVAL 571
Query: 600 LSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTC 659
L+ LG + L + +IF R+ TP+V+S+GG +C+++L + + ++G P+ TC
Sbjct: 572 LAALGFLSTLAILVIFWRHFQTPIVRSAGG-PMCFLMLTLLLVAYMVVPVYVGPPKVSTC 630
Query: 660 KTRQTMFGVSFTLCISCILTKSLKILLAF---SFDPKLQKFLKCLYRPILIIFTCTGIQV 716
RQ +F + FT+CISCI +S +I+ AF S P+ + P + + T +++
Sbjct: 631 LCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKM 690
Query: 717 VICTLWLIFA--APTVEVNVSLPRVIILECEEG--SILAFGTMLGYIAILAFICFIFAFK 772
VI + ++ +PT + P++ I+ C + L F T L +L+ + F FA+
Sbjct: 691 VIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLD--LLLSVVGFSFAYM 748
Query: 773 GKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTF 830
GK NYNEAKFIT M YF + ++ + G V V+++V +++ I F
Sbjct: 749 GKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLGYF 808
Query: 831 IPKCYVIICKQEINTKSAFLKMIYSYS 857
PKCY+I+ E NT + F MI Y+
Sbjct: 809 GPKCYMILFYPERNTPAYFNSMIQGYT 835
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 300 bits (769), Expect = 3e-81
Identities = 232/849 (27%), Positives = 391/849 (46%), Gaps = 90/849 (10%)
Query: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNST-LLPG 92
G +++GGLF I+EK +E+ R I E G + + AM+ +I+ IN LLPG
Sbjct: 37 GDLVLGGLFPINEKGTGTEECGR---INEDRGIQ-----RLEAMLFAIDEINKDDYLLPG 88
Query: 93 VKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR------VKAVIGS 146
VKLG I DTC+ T A+ +L F+ + E+ C SY + + VIG
Sbjct: 89 VKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGG 148
Query: 147 GYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKS 206
YS +++ V+ +L L +PQ+ Y ST+ LSDK R+ F RTVP DF+Q KAMA +++
Sbjct: 149 SYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFF 208
Query: 207 GWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKII 266
W ++ + ++ DYG + F +A N+CIA E + + I + +++++
Sbjct: 209 NWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKV----GRSNIRKSYDSVIRELL 264
Query: 267 LEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGF 326
+ V+V+F+R +L A N + W+ASD W I G +
Sbjct: 265 QKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAIT-L 323
Query: 327 AFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAY 386
+ F + Q+L+ + + ++ C+ + N
Sbjct: 324 ELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCS----------LQNKRNHRRVC 373
Query: 387 KANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWEL 446
+ AI+ + +Y + I + AV+A+ +A+ + Q C PN + +
Sbjct: 374 DKHLAIDSS---------NYEQESKIMFVVNAVYAMAHALHKM-QRTLC--PNTTKLCDA 421
Query: 447 LGVLKN----------VTFTDGWNS-------FHFDAHGDLNTGYDVVLWKEINGHMTVT 489
+ +L + FT +N FD GD Y+V ++ + G +
Sbjct: 422 MKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYL 481
Query: 490 KMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCP 549
K+ + + + ++N S+CS C+P +MK +CC+ C C
Sbjct: 482 KVGHWAETLSLDVNSIHWSRNSVPT-----SQCSDPCAPNEMKNMQPGD-VCCWICIPCE 535
Query: 550 ENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVL 609
Y D C+ C + W T C++ +Y+ W D+ AI + ++ LG +
Sbjct: 536 PYEYL--ADEFTCMDCGSG-QWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTC 592
Query: 610 VVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVS 669
+V +F ++ NTP+VK+SG +CY++L L++ T FFI +P C R+ G S
Sbjct: 593 MVVTVFIKHNNTPLVKASGR-ELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSS 651
Query: 670 FTLCISCILTKS---LKILLAFSFDPKLQKFLKCLYRPILIIFTCTG---IQVVICTLWL 723
F +C S +LTK+ +I + KF+ P +F C G +Q+V+ ++WL
Sbjct: 652 FAICYSALLTKTNCIARIFDGVKNGAQRPKFIS----PSSQVFICLGLILVQIVMVSVWL 707
Query: 724 IFAAP-TVEVNVSLPR-VIILEC--EEGSILAFGTMLGYIAILAFICFIFAFKGKY--EN 777
I AP T ++ R +IL+C ++ S+L L Y IL +C ++AFK + EN
Sbjct: 708 ILEAPGTRRYTLAEKRETVILKCNVKDSSML---ISLTYDVILVILCTVYAFKTRKCPEN 764
Query: 778 YNEAKFITFGMLIYFIAWITFIPIYATTFGKY--VPAVEIIVILISNYGILYCTFIPKCY 835
+NEAKFI F M I W+ F+PI+ T Y I + +S + +L C F PK +
Sbjct: 765 FNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVH 824
Query: 836 VIICKQEIN 844
+I+ + + N
Sbjct: 825 IILFQPQKN 833
>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
[Homo sapiens]
Length = 872
Score = 283 bits (724), Expect = 5e-76
Identities = 232/839 (27%), Positives = 379/839 (45%), Gaps = 60/839 (7%)
Query: 31 TSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNST-L 89
T G +++GGLF +H+K +ED + E G + + AM+ +++ IN L
Sbjct: 27 TLEGDLVLGGLFPVHQKGGPAEDCG---PVNEHRGIQ-----RLEAMLFALDRINRDPHL 78
Query: 90 LPGVKLGYEIYDTCTEVTVAMAATLRFL-SKFNCSRETVEFKCDYSSYMPR------VKA 142
LPGV+LG I D+C++ T A+ L F+ + + + C SY +
Sbjct: 79 LPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITG 138
Query: 143 VIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHL 202
VIG YS++++ V+ +L L +PQ+ Y ST+ LSDK R+ F RTVP DF Q KAMA +
Sbjct: 139 VIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEI 198
Query: 203 IQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTL 262
++ W ++ + ++ DYG + F ++A A N+C+A E + +S E + L
Sbjct: 199 LRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALL 258
Query: 263 KKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGK 322
+K V V+F R +L + +N + W+ASD W + G
Sbjct: 259 QK----PSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGA 314
Query: 323 VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQR 382
+ IS F S+ Q+L + + E+ C++ + D + HS R
Sbjct: 315 IT-IELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSF-RQRDCAA----HSLR 368
Query: 383 TLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQ 442
+ ++ I FV+ A + H++ AL LC A N
Sbjct: 369 AVPFEQESKI--MFVVN-------AVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLY 419
Query: 443 PWELLGVLKNVTF--TDGWNSFHFDAHGDLNTGYDVVLW-KEINGHMTVTKMAEY--DLQ 497
+L V + F D N FD GD Y++ + + +G K+ + L
Sbjct: 420 KDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLT 479
Query: 498 NDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQT 557
D +IP S+CS+ C ++ K+ + +CC+ C C Y +
Sbjct: 480 LDTSLIPWASPSAG----PLPASRCSEPCLQNEV-KSVQPGEVCCWLCIPCQPYEY--RL 532
Query: 558 DMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTR 617
D C C +W T CFE EY+ W D+ A+ + ++ LG + L V +F R
Sbjct: 533 DEFTCADC-GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVR 591
Query: 618 NLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCI 677
+ TPVVK+S G +CY++L FL + T FI +P C R+ G +F++C S +
Sbjct: 592 HNATPVVKAS-GRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSAL 650
Query: 678 LTKSLKILLAFS---FDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNV 734
LTK+ +I F + +F+ + + + +G Q++I WL+ AP
Sbjct: 651 LTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISG-QLLIVVAWLVVEAPGTGKET 709
Query: 735 SLPR--VIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLI 790
+ R V+ L C G+ L Y +L +C ++AFK + EN+NEAKFI F M
Sbjct: 710 APERREVVTLRCNHRDASMLGS-LAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYT 768
Query: 791 YFIAWITFIPIYATTFGKYVPAVEIIVILISNYG--ILYCTFIPKCYVIICKQEINTKS 847
I W+ F+PI+ T Y + + +S G +L C F PK ++I+ + + N S
Sbjct: 769 TCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVS 827
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 280 bits (716), Expect = 4e-75
Identities = 264/963 (27%), Positives = 424/963 (44%), Gaps = 81/963 (8%)
Query: 4 LIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRR-PQIQE 62
L+++++ ++ Q+ + V A PG IIIG LF++H + + R+ ++E
Sbjct: 3 LLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVRE 62
Query: 63 CVGFEISVFLQTLAMIHSIEMINNS-TLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFN 121
G + + AM+H++E IN+ TLLP + LG EI D+C VA+ ++ F+
Sbjct: 63 QYGIQ-----RVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSL 117
Query: 122 CSRETVE--FKC-DYSSYMPRVK----AVIGSGYSEITMAVSRMLNLQLMPQVGYESTAE 174
S E E +C D SS R K VIG G S + + V +L L +PQ+ Y +T+
Sbjct: 118 ISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSM 177
Query: 175 ILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEA 234
LSDK F F+R VPSD Q +AM ++++ W ++ + T+ +YG + F +
Sbjct: 178 DLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAK 237
Query: 235 NNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILE-AQVNVIVVFLRQFHVFDLFNKAIEM 293
+CIA + N E ++ LKK+ + V+ F V L +
Sbjct: 238 EGICIAHSYK----IYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRL 293
Query: 294 NI--NKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSH 351
+ + + SD W+ +T + +G + + ++ F + L L P +H
Sbjct: 294 GLAGEFLLLGSDGWADRYDVTDGYQREAVGGIT-IKLQSPDVKWFDDYY--LKLRPETNH 350
Query: 352 K--LLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEP 409
+ E+ H C + Q Y NK + ++ + D
Sbjct: 351 RNPWFQEFWQHRFQCR----------LEGFPQENSKY--NKTCNSSLTLKTHHVQDSKMG 398
Query: 410 GLIHSIQLAVFALGYAIRDLC--QARDCQNPNAFQPWELLGVLKNVTFTD-GWNSFHFDA 466
+I++I + L LC A C +LL L FT ++ FD
Sbjct: 399 FVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDE 458
Query: 467 HGDLNTGYDVVLWKEI-NGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKE 525
+GD Y+++ +KE+ + + +D N + D E ++ N+ I+S CS+
Sbjct: 459 NGDSPGRYEIMNFKEMGKDYFDYINVGSWD--NGELKMDDDEVWSKKSNI--IRSVCSEP 514
Query: 526 CSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVE 585
C GQ+K + + CC+ C C EN Y D C C + W T C V+
Sbjct: 515 CEKGQIKVIRKGEVSCCWTCTPCKENEYV--FDEYTCKACQLGS-WPTDDLTGCDLIPVQ 571
Query: 586 YLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFA 645
YL W D I ++ + LG++ L V ++F +TPVVKSS +CY+IL L +
Sbjct: 572 YLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSS-SRELCYIILAGICLGYL 630
Query: 646 STSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKI--LLAFS---FDPKLQKFLK- 699
T I +P+ C ++ G+S + S ++TK+ +I +LA S K +F+
Sbjct: 631 CTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSA 690
Query: 700 CLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYI 759
C I I C IQ+ I I P + + R + L C + L T LGY
Sbjct: 691 CAQLVIAFILIC--IQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTN-LGVVTPLGYN 747
Query: 760 AILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFG-KYVPAVEII 816
+L C +AFK + N+NEAK+I F M I W+ F+PIY FG Y
Sbjct: 748 GLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIY---FGSNYKIITMCF 804
Query: 817 VILISNYGILYCTFIPKCYVIICKQEINTKSAFLKM------IYSYSSHSVSSIALSPAS 870
+ +S L C F+PK Y+I+ K E N +SAF + S S +S + S +
Sbjct: 805 SVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVN 864
Query: 871 LDSMSGNVTMTNPSSSGKSATW------QKSKDLQAQAFAHICRE---NATSVSKTLPRK 921
L G+ T SS+GKS TW + + L + HI ++ N T+V K P+
Sbjct: 865 LWKRRGSSGET-LSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKS 923
Query: 922 RMS 924
S
Sbjct: 924 TES 926
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 272 bits (696), Expect = 9e-73
Identities = 265/994 (26%), Positives = 424/994 (42%), Gaps = 111/994 (11%)
Query: 4 LIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRR-PQIQE 62
L+++++ ++ Q+ + V A PG IIIG LF++H + + R+ ++E
Sbjct: 3 LLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVRE 62
Query: 63 CVGFEISVFLQTLAMIHSIEMINNS-TLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFN 121
G + + AM+H++E IN+ TLLP + LG EI D+C VA+ ++ F+
Sbjct: 63 QYGIQ-----RVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSL 117
Query: 122 CSRETVE--FKC-DYSSYMPRVK----AVIGSGYSEITMAVSRMLNLQLMPQVGYESTAE 174
S E E +C D SS R K VIG G S + + V +L L +PQ+ Y +T+
Sbjct: 118 ISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSM 177
Query: 175 ILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEA 234
LSDK F F+R VPSD Q +AM ++++ W ++ + T+ +YG + F +
Sbjct: 178 DLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAK 237
Query: 235 NNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILE-AQVNVIVVFLRQFHVFDLFNKAIEM 293
+CIA + N E ++ LKK+ + V+ F V L +
Sbjct: 238 EGICIAHSYK----IYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRL 293
Query: 294 NI--NKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSH 351
+ + + SD W+ +T + +G + + ++ F + L L P +H
Sbjct: 294 GLAGEFLLLGSDGWADRYDVTDGYQREAVGGIT-IKLQSPDVKWFDDYY--LKLRPETNH 350
Query: 352 K--LLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEP 409
+ E+ H C + Q Y NK + ++ + D
Sbjct: 351 RNPWFQEFWQHRFQCR----------LEGFPQENSKY--NKTCNSSLTLKTHHVQDSKMG 398
Query: 410 GLIHSIQLAVFALGYAIRDLC--QARDCQNPNAFQPWELLGVLKNVTFTD-GWNSFHFDA 466
+I++I + L LC A C +LL L FT ++ FD
Sbjct: 399 FVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDE 458
Query: 467 HGDLNTGYDVVLWKEI-NGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKE 525
+GD Y+++ +KE+ + + +D N + D E ++ N+ I+S CS+
Sbjct: 459 NGDSPGRYEIMNFKEMGKDYFDYINVGSWD--NGELKMDDDEVWSKKSNI--IRSVCSEP 514
Query: 526 CSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVE 585
C GQ+K + + CC+ C C EN Y D C C + W T C V+
Sbjct: 515 CEKGQIKVIRKGEVSCCWTCTPCKENEYV--FDEYTCKACQLGS-WPTDDLTGCDLIPVQ 571
Query: 586 YLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFA 645
YL W D I ++ + LG++ L V ++F +TPVVKSS +CY+IL L +
Sbjct: 572 YLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSS-SRELCYIILAGICLGYL 630
Query: 646 STSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKI--LLAFS---FDPKLQKFLK- 699
T I +P+ C ++ G+S + S ++TK+ +I +LA S K +F+
Sbjct: 631 CTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSA 690
Query: 700 CLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYI 759
C I I C IQ+ I I P + + R + L C + L T LGY
Sbjct: 691 CAQLVIAFILIC--IQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTN-LGVVTPLGYN 747
Query: 760 AILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFG-KYVPAVEII 816
+L C +AFK + N+NEAK+I F M I W+ F+PIY FG Y
Sbjct: 748 GLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIY---FGSNYKIITMCF 804
Query: 817 VILISNYGILYCTFIPKCYVIICKQEINTKSAFL--KMIYSYSSHSVSSIALSPAS---- 870
+ +S L C F+PK Y+I+ K E N +SAF ++ + SS A S +S
Sbjct: 805 SVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVN 864
Query: 871 -------------------------------LDSMSGNVTMTNPSSSGKSATW------Q 893
SM T SS+GKS TW
Sbjct: 865 LWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSS 924
Query: 894 KSKDLQAQAFAHICRE---NATSVSKTLPRKRMS 924
+ + L + HI ++ N T+V K P+ S
Sbjct: 925 RGQHLWQRLSIHINKKENPNQTAVIKPFPKSTES 958
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 255 bits (652), Expect = 1e-67
Identities = 236/904 (26%), Positives = 399/904 (44%), Gaps = 84/904 (9%)
Query: 30 ATSPGHIIIGGLFAIHEKMLSSEDSPRRP--QIQECVGFEISVFLQTLAMIHSIEMIN-N 86
A G +IIG LF++H + +E P R +I+E G + + AM H+++ IN +
Sbjct: 39 ARMDGDVIIGALFSVHHQP-PAEKVPERKCGEIREQYGIQ-----RVEAMFHTLDKINAD 92
Query: 87 STLLPGVKLGYEIYDTCTEVTVAMAATLRF----LSKFNCSRETVEFKC--DYSSYMPR- 139
LLP + LG EI D+C +VA+ ++ F L ++ + +C D S P
Sbjct: 93 PVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGIN-RCLPDGQSLPPGR 151
Query: 140 ----VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQ 195
+ VIG G S + + V +L L +PQ+ Y +T+ LSDK + FLR VPSD Q
Sbjct: 152 TKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQ 211
Query: 196 IKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIE 255
+AM ++++ W ++ + T+ +YG ++ F A +CIA + + + + + +
Sbjct: 212 ARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFD 271
Query: 256 VRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNI--NKMWIASDNWSTATKITT 313
R+ R L++ + +A+ V+V F V L + + + I SD W+ ++
Sbjct: 272 -RLLRKLRERLPKAR--VVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIE 328
Query: 314 IPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLS 373
V+ G + + + SF + L L + + E+ H C L
Sbjct: 329 GYEVEANGGIT-IKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCR------LP 381
Query: 374 QCIFNHSQRTLAYKANKAIERNFVM--RNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQ 431
+ + N+++E N+V + F+ + A + H +Q AL LC
Sbjct: 382 GHLLENPNFKRICTGNESLEENYVQDSKMGFVIN-AIYAMAHGLQNMHHALCPGHVGLCD 440
Query: 432 ARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKM 491
A + + + + V+ + W FD GD YD++ ++ T+
Sbjct: 441 AMKPIDGSKLLDFLIKSSFIGVSGEEVW----FDEKGDAPGRYDIM-------NLQYTEA 489
Query: 492 AEYDLQN----DVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQN 547
YD + ++ + K + ++S CS+ C GQ+K + + CC+ C
Sbjct: 490 NRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTA 549
Query: 548 CPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIF 607
C EN Y D C C + W T C V YL W++ +I+ + S LGI+
Sbjct: 550 CKENEYVQ--DEFTCKAC-DLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILV 606
Query: 608 VLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFG 667
L V +IF +TPVVKSS +CY+IL FL + I +P +C ++ + G
Sbjct: 607 TLFVTLIFVLYRDTPVVKSS-SRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVG 665
Query: 668 VSFTLCISCILTKSLKI--LLAFS---FDPKLQKFLKCLYRPILIIFTCTGIQVVICTLW 722
+S +C S ++TK+ +I +LA S + +F+ + ++I +Q+ +
Sbjct: 666 LSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSA-WAQVIIASILISVQLTLVVTL 724
Query: 723 LIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNE 780
+I P ++ + + L C S L LGY +L C +AFK + N+NE
Sbjct: 725 IIMEPPMPILSYPSIKEVYLICNT-SNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNE 783
Query: 781 AKFITFGMLIYFIAWITFIPIYATTFG-KYVPAVEIIVILISNYGILYCTFIPKCYVIIC 839
AK+I F M I W+ F+PIY FG Y + +S L C F PK Y+II
Sbjct: 784 AKYIAFTMYTTCIIWLAFVPIY---FGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA 840
Query: 840 KQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSG---------NVTMTNPSSSGKSA 890
K E N +SAF ++ V + + L S N +S+GKS
Sbjct: 841 KPERNVRSAF-------TTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSV 893
Query: 891 TWQK 894
+W +
Sbjct: 894 SWSE 897
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 254 bits (650), Expect = 2e-67
Identities = 227/850 (26%), Positives = 382/850 (44%), Gaps = 68/850 (8%)
Query: 30 ATSPGHIIIGGLFAIHEKMLSSEDSPRRP--QIQECVGFEISVFLQTLAMIHSIEMIN-N 86
A G +IIG LF++H + +E P R +I+E G + + AM H+++ IN +
Sbjct: 39 ARMDGDVIIGALFSVHHQP-PAEKVPERKCGEIREQYGIQ-----RVEAMFHTLDKINAD 92
Query: 87 STLLPGVKLGYEIYDTCTEVTVAMAATLRF----LSKFNCSRETVEFKC--DYSSYMPR- 139
LLP + LG EI D+C +VA+ ++ F L ++ + +C D S P
Sbjct: 93 PVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGIN-RCLPDGQSLPPGR 151
Query: 140 ----VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQ 195
+ VIG G S + + V +L L +PQ+ Y +T+ LSDK + FLR VPSD Q
Sbjct: 152 TKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQ 211
Query: 196 IKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIE 255
+AM ++++ W ++ + T+ +YG ++ F A +CIA + + + + + +
Sbjct: 212 ARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFD 271
Query: 256 VRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNI--NKMWIASDNWSTATKITT 313
R+ R L++ + +A+ V+V F V L + + + I SD W+ ++
Sbjct: 272 -RLLRKLRERLPKAR--VVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIE 328
Query: 314 IPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLS 373
V+ G + + + SF + L L + + E+ H C L
Sbjct: 329 GYEVEANGGIT-IKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCR------LP 381
Query: 374 QCIFNHSQRTLAYKANKAIERNFVM--RNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQ 431
+ + N+++E N+V + F+ + A + H +Q AL LC
Sbjct: 382 GHLLENPNFKRICTGNESLEENYVQDSKMGFVIN-AIYAMAHGLQNMHHALCPGHVGLCD 440
Query: 432 ARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKM 491
A + + + + V+ + W FD GD YD++ ++ T+
Sbjct: 441 AMKPIDGSKLLDFLIKSSFIGVSGEEVW----FDEKGDAPGRYDIM-------NLQYTEA 489
Query: 492 AEYDLQN----DVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQN 547
YD + ++ + K + ++S CS+ C GQ+K + + CC+ C
Sbjct: 490 NRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTA 549
Query: 548 CPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIF 607
C EN Y D C C + W T C V YL W++ +I+ + S LGI+
Sbjct: 550 CKENEYVQ--DEFTCKAC-DLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILV 606
Query: 608 VLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFG 667
L V +IF +TPVVKSS +CY+IL FL + I +P +C ++ + G
Sbjct: 607 TLFVTLIFVLYRDTPVVKSS-SRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVG 665
Query: 668 VSFTLCISCILTKSLKI--LLAFS---FDPKLQKFLKCLYRPILIIFTCTGIQVVICTLW 722
+S +C S ++TK+ +I +LA S + +F+ + ++I +Q+ +
Sbjct: 666 LSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSA-WAQVIIASILISVQLTLVVTL 724
Query: 723 LIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNE 780
+I P ++ + + L C S L LGY +L C +AFK + N+NE
Sbjct: 725 IIMEPPMPILSYPSIKEVYLICNT-SNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNE 783
Query: 781 AKFITFGMLIYFIAWITFIPIYATTFG-KYVPAVEIIVILISNYGILYCTFIPKCYVIIC 839
AK+I F M I W+ F+PIY FG Y + +S L C F PK Y+II
Sbjct: 784 AKYIAFTMYTTCIIWLAFVPIY---FGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA 840
Query: 840 KQEINTKSAF 849
K E N +SAF
Sbjct: 841 KPERNVRSAF 850
>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
[Homo sapiens]
Length = 908
Score = 249 bits (636), Expect = 8e-66
Identities = 221/875 (25%), Positives = 388/875 (44%), Gaps = 74/875 (8%)
Query: 6 ILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVG 65
+L F IL Q + + + G II+GGLF +H K E ++++ G
Sbjct: 16 LLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAK---GERGVPCGELKKEKG 72
Query: 66 FEISVFLQTLAMIHSIEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSR 124
+ AM+++I+ IN LL + LG I DTC+ T A+ +L F+ +
Sbjct: 73 IH-----RLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL-IEK 126
Query: 125 ETVEFKCDYS-----SYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDK 179
+ + KC + ++ VIG+ S +++ V+ +L L +PQ+ Y STA LSD
Sbjct: 127 DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186
Query: 180 IRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFI-IQAEANNVC 238
R+ F R VP D +Q +AM ++ GWN++ + ++ +YG + F I E VC
Sbjct: 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVC 246
Query: 239 IAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK- 297
IA + +P E + +K+++ +++F + + + A ++N +
Sbjct: 247 IAQSQKIPREPRPGEFE----KIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGH 302
Query: 298 -MWIASDNWSTATKITTIPNVKKIGK-VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLH 355
+WI SD+W +KI + ++I + V +R +I F + ++ L + +
Sbjct: 303 FLWIGSDSW--GSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360
Query: 356 EYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSI 415
E+ C + +H +R K +ER + R+ Y + G + +
Sbjct: 361 EFWEENFGCK----------LGSHGKRNSHIKKCTGLER--IARDS---SYEQEGKVQFV 405
Query: 416 QLAVFALGYAI----RDLCQARD--CQNPNAFQPWELLGVLKNVTFT-DGWNSFHFDAHG 468
AV+++ YA+ +DLC C + ELLG ++ V F F+ +G
Sbjct: 406 IDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENG 465
Query: 469 DLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSP 528
D YD+ ++ N + + Q + + ++ + R S CS C P
Sbjct: 466 DAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKV---EDMQWAHREHTHPASVCSLPCKP 522
Query: 529 GQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLN 588
G+ KKT + CC+ C+ C Y Q D C LC + T C + L
Sbjct: 523 GERKKTVKGVP-CCWHCERC--EGYNYQVDELSCELCPLDQR-PNMNRTGCQLIPIIKLE 578
Query: 589 WNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTS 648
W+ A++ + +++LGII V + F R +TP+V++S G + YV+L FL ++ T
Sbjct: 579 WHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRAS-GRELSYVLLTGIFLCYSITF 637
Query: 649 FFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPK---LQKFLKCLYRPI 705
I P C R+ G+ + +LTK+ +I F K KF+ + +
Sbjct: 638 LMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQ-L 696
Query: 706 LIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGY 758
+I F+ +Q++ +W + P + ++ R + +L+C+ S L+ LGY
Sbjct: 697 VITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDI-SDLSLICSLGY 755
Query: 759 IAILAFICFIFAFK--GKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPA 812
+L C ++A K G E +NEAK I F M I W+ FIPI+ T Y+
Sbjct: 756 SILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQT 815
Query: 813 VEIIVILISNYGI-LYCTFIPKCYVIICKQEINTK 846
+ V + + + L ++PK Y+II E N +
Sbjct: 816 TTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
[Homo sapiens]
Length = 908
Score = 249 bits (636), Expect = 8e-66
Identities = 221/875 (25%), Positives = 388/875 (44%), Gaps = 74/875 (8%)
Query: 6 ILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVG 65
+L F IL Q + + + G II+GGLF +H K E ++++ G
Sbjct: 16 LLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAK---GERGVPCGELKKEKG 72
Query: 66 FEISVFLQTLAMIHSIEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSR 124
+ AM+++I+ IN LL + LG I DTC+ T A+ +L F+ +
Sbjct: 73 IH-----RLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL-IEK 126
Query: 125 ETVEFKCDYS-----SYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDK 179
+ + KC + ++ VIG+ S +++ V+ +L L +PQ+ Y STA LSD
Sbjct: 127 DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186
Query: 180 IRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFI-IQAEANNVC 238
R+ F R VP D +Q +AM ++ GWN++ + ++ +YG + F I E VC
Sbjct: 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVC 246
Query: 239 IAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK- 297
IA + +P E + +K+++ +++F + + + A ++N +
Sbjct: 247 IAQSQKIPREPRPGEFE----KIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGH 302
Query: 298 -MWIASDNWSTATKITTIPNVKKIGK-VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLH 355
+WI SD+W +KI + ++I + V +R +I F + ++ L + +
Sbjct: 303 FLWIGSDSW--GSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360
Query: 356 EYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSI 415
E+ C + +H +R K +ER + R+ Y + G + +
Sbjct: 361 EFWEENFGCK----------LGSHGKRNSHIKKCTGLER--IARDS---SYEQEGKVQFV 405
Query: 416 QLAVFALGYAI----RDLCQARD--CQNPNAFQPWELLGVLKNVTFT-DGWNSFHFDAHG 468
AV+++ YA+ +DLC C + ELLG ++ V F F+ +G
Sbjct: 406 IDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENG 465
Query: 469 DLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSP 528
D YD+ ++ N + + Q + + ++ + R S CS C P
Sbjct: 466 DAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKV---EDMQWAHREHTHPASVCSLPCKP 522
Query: 529 GQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLN 588
G+ KKT + CC+ C+ C Y Q D C LC + T C + L
Sbjct: 523 GERKKTVKGVP-CCWHCERC--EGYNYQVDELSCELCPLDQR-PNMNRTGCQLIPIIKLE 578
Query: 589 WNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTS 648
W+ A++ + +++LGII V + F R +TP+V++S G + YV+L FL ++ T
Sbjct: 579 WHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRAS-GRELSYVLLTGIFLCYSITF 637
Query: 649 FFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPK---LQKFLKCLYRPI 705
I P C R+ G+ + +LTK+ +I F K KF+ + +
Sbjct: 638 LMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQ-L 696
Query: 706 LIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGY 758
+I F+ +Q++ +W + P + ++ R + +L+C+ S L+ LGY
Sbjct: 697 VITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDI-SDLSLICSLGY 755
Query: 759 IAILAFICFIFAFK--GKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPA 812
+L C ++A K G E +NEAK I F M I W+ FIPI+ T Y+
Sbjct: 756 SILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQT 815
Query: 813 VEIIVILISNYGI-LYCTFIPKCYVIICKQEINTK 846
+ V + + + L ++PK Y+II E N +
Sbjct: 816 TTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
Length = 877
Score = 243 bits (619), Expect = 8e-64
Identities = 230/885 (25%), Positives = 386/885 (43%), Gaps = 93/885 (10%)
Query: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMIN-NSTLLPG 92
G + +GGLF +H + + + + Q E AM+++++ +N + LLPG
Sbjct: 37 GGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLE--------AMLYALDRVNADPELLPG 88
Query: 93 VKLGYEIYDTCTEVTVAMAATLRFLSKFNCSR---ETVEFKCDYS------SYMPRVKAV 143
V+LG + DTC+ T A+ L F+ R + V +C + RV AV
Sbjct: 89 VRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAV 148
Query: 144 IGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLI 203
+G+ S +++ V+ +L L +PQ+ Y STA LSD R+ F R VP D +Q +AM ++
Sbjct: 149 VGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIV 208
Query: 204 QKSGWNWIGIITTDDDYGRLALNTFI-IQAEANNVCIAFKEVLPAFLSDNTIEVRINRTL 262
+ GWN++ + ++ +YG + F+ I EA VCIA +P ++ +
Sbjct: 209 RALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPG----EFSKVI 264
Query: 263 KKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK--MWIASDNWSTATK-ITTIPNVKK 319
++++ I++F + + + A + N+ +W+ SD+W T I ++ +V
Sbjct: 265 RRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVA- 323
Query: 320 IGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNH 379
+G + +R +I F + L + + E+ C S
Sbjct: 324 VGAITILP-KRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSD----- 377
Query: 380 SQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPN 439
T + I R+ Y + G + + AV+A+ +A+ + QA C
Sbjct: 378 -DSTRKCTGEERIGRDST--------YEQEGKVQFVIDAVYAIAHALHSMHQAL-CPGHT 427
Query: 440 ----AFQPWE---LLGVLKNVTFTDGWNS-FHFDAHGDLNTGYDVVLWKEING------H 485
A +P + LL ++ V F + F+ +GD YD+ ++ NG +
Sbjct: 428 GLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGY 487
Query: 486 MTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYEC 545
V + AE L+ DV + +E + S CS C PG+ KK + CC+ C
Sbjct: 488 QAVGQWAE-TLRLDVEALQWSGDPHEVPS-----SLCSLPCGPGERKKMVKGVP-CCWHC 540
Query: 546 QNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGI 605
+ C + Y Q D C C P T C V L+W+ A L+L++LGI
Sbjct: 541 EAC--DGYRFQVDEFTCEACPGDMRPTP-NHTGCRPTPVVRLSWSSPWAAPPLLLAVLGI 597
Query: 606 IFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTM 665
+ V F R NTP+V++SG + YV+L FL +A T + EP C R+
Sbjct: 598 VATTTVVATFVRYNNTPIVRASGR-ELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLF 656
Query: 666 FGVSFTLCISCILTKSLKILLAFSFDPKL---QKFLKCLYRPILIIFTCTGIQVVICTLW 722
G+ TL S +LTK+ +I F + F+ + ++I F+ T +QVV W
Sbjct: 657 LGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQ-LVITFSLTSLQVVGMIAW 715
Query: 723 LIFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGYIAILAFICFIFAFK--G 773
L P ++ R + +L+C+ + G LGY +L C ++A K G
Sbjct: 716 LGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIG-CLGYSLLLMVTCTVYAIKARG 774
Query: 774 KYENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPAVEIIVILISNYGI-LYC 828
E +NEAK I F M I W+ F+PI+ T Y+ + V L + + L
Sbjct: 775 VPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGM 834
Query: 829 TFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDS 873
++PK YVI+ E N + S + S++A P D+
Sbjct: 835 LYVPKTYVILFHPEQNVQKR------KRSLKATSTVAAPPKGEDA 873
>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
Length = 912
Score = 239 bits (610), Expect = 9e-63
Identities = 222/846 (26%), Positives = 374/846 (44%), Gaps = 75/846 (8%)
Query: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTL-AMIHSIEMINNST-LLP 91
G I +GGLF +H + SE P C + + L AM+ +++ INN LLP
Sbjct: 47 GDITLGGLFPVHGR--GSEGKP-------CGELKKEKGIHRLEAMLFALDRINNDPDLLP 97
Query: 92 GVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYS-----SYMPRVKAVIGS 146
+ LG I DTC+ T A+ +L F+ ++ E +C + RV VIG+
Sbjct: 98 NITLGARILDTCSRDTHALEQSLTFVQAL-IEKDGTEVRCGSGGPPIITKPERVVGVIGA 156
Query: 147 GYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKS 206
S +++ V+ +L L +PQ+ Y STA LSD R+ F R VPSD +Q +AM +++
Sbjct: 157 SGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRAL 216
Query: 207 GWNWIGIITTDDDYGRLALNTFIIQA-EANNVCIAFKEVLPAFLSDNTIEVRINRTLKKI 265
WN++ + ++ YG + FI ++ E VCIA +P + I R L+
Sbjct: 217 KWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLET- 275
Query: 266 ILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK--MWIASDNWSTATKITTIPNVKKIGK- 322
+ +++F + + + A N W+ SD+W + KI + +++++ +
Sbjct: 276 ---SNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGS--KIAPVLHLEEVAEG 330
Query: 323 VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQR 382
V +R ++ F + S + L ++ + +D C +
Sbjct: 331 AVTILPKRMSVRGFDRYF---------SSRTLDNNRRNIWFAEFWEDN--FHCKLSRHAL 379
Query: 383 TLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAI----RDLCQARD--CQ 436
K R + ++ Y + G + + AV+A+G+A+ RDLC R C
Sbjct: 380 KKGSHVKKCTNRERIGQDSA---YEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCP 436
Query: 437 NPNAFQPWELLGVLKNVTFTD-GWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYD 495
+ +LL ++NV F+ N F+ +GD YD+ ++ N + +
Sbjct: 437 RMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSW- 495
Query: 496 LQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTN 555
D + + + +S CS C PG+ KKT + CC+ C+ C Y
Sbjct: 496 --TDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMP-CCWHCEPCTGYQY-- 550
Query: 556 QTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIF 615
Q D C C R T C + L W A+L L L+++GI L V I F
Sbjct: 551 QVDRYTCKTCPYDMRPTENR-TGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITF 609
Query: 616 TRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCIS 675
R +TP+VK+SG + YV+L FL +A+T I EP TC R+ G+ ++ +
Sbjct: 610 VRYNDTPIVKASGR-ELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYA 668
Query: 676 CILTKSLKILLAFSFDPK---LQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEV 732
+LTK+ +I F + +F+ + + I F+ +Q++ +W + V
Sbjct: 669 ALLTKTNRIYRIFEQGKRSVSAPRFISPASQ-LAITFSLISLQLLGICVWFVVDPSHSVV 727
Query: 733 NVSLPRVI-------ILECEEGSILAFGTMLGYIAILAFICFIFAFK--GKYENYNEAKF 783
+ R + +L+C+ S L+ +LGY +L C ++A K G E +NEAK
Sbjct: 728 DFQDQRTLDPRFARGVLKCDI-SDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKP 786
Query: 784 ITFGMLIYFIAWITFIPIYATTFGK----YVPAVEIIV-ILISNYGILYCTFIPKCYVII 838
I F M I W+ FIPI+ T Y+ + V + +S L ++PK Y+I+
Sbjct: 787 IGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIIL 846
Query: 839 CKQEIN 844
E N
Sbjct: 847 FHPEQN 852
>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
[Homo sapiens]
Length = 922
Score = 230 bits (587), Expect = 4e-60
Identities = 220/857 (25%), Positives = 379/857 (44%), Gaps = 90/857 (10%)
Query: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTL-AMIHSIEMINNS-TLLP 91
G + +GGLF +H K P C + + L AM+++++ IN+ LLP
Sbjct: 47 GDVTLGGLFPVHAK---------GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLP 97
Query: 92 GVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVK-----AVIGS 146
V LG I DTC+ T A+ +L F+ ++T + +C VK VIG+
Sbjct: 98 NVTLGARILDTCSRDTYALEQSLTFVQAL-IQKDTSDVRCTNGEPPVFVKPEKVVGVIGA 156
Query: 147 GYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKS 206
S +++ V+ +L L +PQ+ Y STA LSD R+ F R VP D Q +AM +++
Sbjct: 157 SGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKAL 216
Query: 207 GWNWIGIITTDDDYGRLALNTFI-IQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKI 265
GWN++ + ++ YG + +F I EA +CIA +P D TI+ +R +K++
Sbjct: 217 GWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTID--FDRIIKQL 274
Query: 266 ILEAQVNVIVVFLRQFHVFDLFN--KAIEMNINKMWIASDNWSTATKITTIPNVKKIGK- 322
+ +V+F + + K + + +W+ SD+W + KI + + I +
Sbjct: 275 LDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGS--KINPLHQHEDIAEG 332
Query: 323 VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYV------KDTDLSQCI 376
+ +R + F ++ + L + + EY C +DTD +C
Sbjct: 333 AITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTD-RKCT 391
Query: 377 FNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAI----RDLCQA 432
Q + +N Y + G + + AV+A+ +A+ +DLC
Sbjct: 392 ---GQERIGKDSN----------------YEQEGKVQFVIDAVYAMAHALHHMNKDLCAD 432
Query: 433 RDCQNPNAFQPW--ELLGVLKNVTFTDGWNS-FHFDAHGDLNTGYDVVLWKEIN----GH 485
P Q +LL ++NV F + F+ +GD YD+ ++ N G+
Sbjct: 433 YRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGY 492
Query: 486 MTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYEC 545
+ + + +LQ + I D + R + S C+ C PGQ KKT + CC+ C
Sbjct: 493 RLIGQWTD-ELQLN---IEDMQWGKGVREIPA--SVCTLPCKPGQRKKTQKGTP-CCWTC 545
Query: 546 QNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGI 605
+ C + Y Q D C C R T C + + L W+ A++ + L++LGI
Sbjct: 546 EPC--DGYQYQFDEMTCQHCPYDQRPNENR-TGCQDIPIIKLEWHSPWAVIPVFLAMLGI 602
Query: 606 IFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTM 665
I + V F R +TP+V++S G + YV+L FL + T I +P C R+
Sbjct: 603 IATIFVMATFIRYNDTPIVRAS-GRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVF 661
Query: 666 FGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCL--YRPILIIFTCTGIQVVICTLWL 723
G+ + + +LTK+ +I F K + + + I + +Q++ +W
Sbjct: 662 LGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWF 721
Query: 724 IFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGYIAILAFICFIFAFK--GK 774
P + ++ + + +L+C+ + L LGY +L C ++A K G
Sbjct: 722 GVDPPNIIIDYDEHKTMNPEQARGVLKCDI-TDLQIICSLGYSILLMVTCTVYAIKTRGV 780
Query: 775 YENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPAVEIIVIL-ISNYGILYCT 829
EN+NEAK I F M I W+ FIPI+ T Y+ + + + +S L
Sbjct: 781 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML 840
Query: 830 FIPKCYVIICKQEINTK 846
++PK Y+II E+N +
Sbjct: 841 YMPKVYIIIFHPELNVQ 857
>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
[Homo sapiens]
Length = 915
Score = 230 bits (587), Expect = 4e-60
Identities = 220/857 (25%), Positives = 379/857 (44%), Gaps = 90/857 (10%)
Query: 34 GHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTL-AMIHSIEMINNS-TLLP 91
G + +GGLF +H K P C + + L AM+++++ IN+ LLP
Sbjct: 47 GDVTLGGLFPVHAK---------GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLP 97
Query: 92 GVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVK-----AVIGS 146
V LG I DTC+ T A+ +L F+ ++T + +C VK VIG+
Sbjct: 98 NVTLGARILDTCSRDTYALEQSLTFVQAL-IQKDTSDVRCTNGEPPVFVKPEKVVGVIGA 156
Query: 147 GYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKS 206
S +++ V+ +L L +PQ+ Y STA LSD R+ F R VP D Q +AM +++
Sbjct: 157 SGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKAL 216
Query: 207 GWNWIGIITTDDDYGRLALNTFI-IQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKI 265
GWN++ + ++ YG + +F I EA +CIA +P D TI+ +R +K++
Sbjct: 217 GWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTID--FDRIIKQL 274
Query: 266 ILEAQVNVIVVFLRQFHVFDLFN--KAIEMNINKMWIASDNWSTATKITTIPNVKKIGK- 322
+ +V+F + + K + + +W+ SD+W + KI + + I +
Sbjct: 275 LDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGS--KINPLHQHEDIAEG 332
Query: 323 VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYV------KDTDLSQCI 376
+ +R + F ++ + L + + EY C +DTD +C
Sbjct: 333 AITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTD-RKCT 391
Query: 377 FNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAI----RDLCQA 432
Q + +N Y + G + + AV+A+ +A+ +DLC
Sbjct: 392 ---GQERIGKDSN----------------YEQEGKVQFVIDAVYAMAHALHHMNKDLCAD 432
Query: 433 RDCQNPNAFQPW--ELLGVLKNVTFTDGWNS-FHFDAHGDLNTGYDVVLWKEIN----GH 485
P Q +LL ++NV F + F+ +GD YD+ ++ N G+
Sbjct: 433 YRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGY 492
Query: 486 MTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYEC 545
+ + + +LQ + I D + R + S C+ C PGQ KKT + CC+ C
Sbjct: 493 RLIGQWTD-ELQLN---IEDMQWGKGVREIPA--SVCTLPCKPGQRKKTQKGTP-CCWTC 545
Query: 546 QNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGI 605
+ C + Y Q D C C R T C + + L W+ A++ + L++LGI
Sbjct: 546 EPC--DGYQYQFDEMTCQHCPYDQRPNENR-TGCQDIPIIKLEWHSPWAVIPVFLAMLGI 602
Query: 606 IFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTM 665
I + V F R +TP+V++S G + YV+L FL + T I +P C R+
Sbjct: 603 IATIFVMATFIRYNDTPIVRAS-GRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVF 661
Query: 666 FGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCL--YRPILIIFTCTGIQVVICTLWL 723
G+ + + +LTK+ +I F K + + + I + +Q++ +W
Sbjct: 662 LGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWF 721
Query: 724 IFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGYIAILAFICFIFAFK--GK 774
P + ++ + + +L+C+ + L LGY +L C ++A K G
Sbjct: 722 GVDPPNIIIDYDEHKTMNPEQARGVLKCDI-TDLQIICSLGYSILLMVTCTVYAIKTRGV 780
Query: 775 YENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPAVEIIVIL-ISNYGILYCT 829
EN+NEAK I F M I W+ FIPI+ T Y+ + + + +S L
Sbjct: 781 PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML 840
Query: 830 FIPKCYVIICKQEINTK 846
++PK Y+II E+N +
Sbjct: 841 YMPKVYIIIFHPELNVQ 857
>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
Length = 587
Score = 196 bits (497), Expect = 1e-49
Identities = 122/418 (29%), Positives = 204/418 (48%), Gaps = 9/418 (2%)
Query: 446 LLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPD 505
LL + V F ++ F+ + D + Y+++ W T T + I +
Sbjct: 167 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 226
Query: 506 QETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLC 565
+ + ++ + +S CS +C G + T H CC+EC C + N++D+ C C
Sbjct: 227 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHH-CCFECVPCGAGTFLNKSDLYRCQPC 285
Query: 566 NNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVK 625
K WAP S CF + V +L + + +LL + L ++ +L +F +L+TPVV+
Sbjct: 286 G-KEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVR 344
Query: 626 SSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKIL 685
S+GG R+C+++L S F GEP C RQ +F + FT+ +SC+ +S +++
Sbjct: 345 SAGG-RLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLI 403
Query: 686 LAFSFDPKLQKFLKCLYRPI---LIIFTCTGIQVVICTLWLIFAAPTVEVNVS-LPRVII 741
+ F F K+ F + L + + Q++IC WL+ P P +++
Sbjct: 404 IIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVM 463
Query: 742 LECEEGSILAFGTMLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFI 799
LEC E + L F Y +L+ F ++ GK ENYNEAK +TF +L F++WI F
Sbjct: 464 LECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFF 523
Query: 800 PIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYS 857
+ GKY+PA ++ L S F+PKCYVI+C+ ++N+ F I Y+
Sbjct: 524 TTASVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYT 581
Score = 65.5 bits (158), Expect = 2e-10
Identities = 46/148 (31%), Positives = 69/148 (46%), Gaps = 4/148 (2%)
Query: 21 CQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHS 80
C + + T PG ++ GLF +H L P F + AM
Sbjct: 23 CHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLG 82
Query: 81 IEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139
+E INNST LLP + LGY++YD C++ + + ATLR LS + +E + D Y P
Sbjct: 83 VEEINNSTALLPNITLGYQLYDVCSD-SANVYATLRVLSL--PGQHHIELQGDLLHYSPT 139
Query: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQV 167
V AVIG + + +L+ L+P +
Sbjct: 140 VLAVIGPDSTNRAATTAALLSPFLVPML 167
>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
Length = 480
Score = 180 bits (456), Expect = 6e-45
Identities = 105/323 (32%), Positives = 172/323 (53%), Gaps = 12/323 (3%)
Query: 21 CQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHS 80
C + + T PG ++ GLF +H L P F + AM
Sbjct: 23 CHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLG 82
Query: 81 IEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139
+E INNST LLP + LGY++YD C++ + + ATLR LS + +E + D Y P
Sbjct: 83 VEEINNSTALLPNITLGYQLYDVCSD-SANVYATLRVLSL--PGQHHIELQGDLLHYSPT 139
Query: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAM 199
V AVIG + + +L+ L+P + Y +++E LS K ++PSFLRT+P+D +Q++ M
Sbjct: 140 VLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETM 199
Query: 200 AHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLP--AFLSDNTIEVR 257
L+QK GW WI ++ + DDYG+L + QA +CIAFK+++P A + D ++
Sbjct: 200 VLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQ-- 257
Query: 258 INRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNI-NKMWIASDNWSTATKITTIPN 316
L + + +A V+VVF + F + N+ K+W+AS+ W+ + IT +P
Sbjct: 258 ---CLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPG 314
Query: 317 VKKIGKVVGFAFRRGNISSFHSF 339
+++IG V+G A ++ + +F
Sbjct: 315 IQRIGMVLGVAIQKRAVPGLKAF 337
>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
sapiens]
Length = 254
Score = 91.3 bits (225), Expect = 4e-18
Identities = 62/210 (29%), Positives = 101/210 (48%), Gaps = 11/210 (5%)
Query: 647 TSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSF---DPKLQKFLKCLYR 703
T FI +P C R+ G +F++C S +LTK+ +I F + +F+ +
Sbjct: 2 TFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQ 61
Query: 704 PILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPR--VIILECEEGSILAFGTMLGYIAI 761
+ + +G Q++I WL+ AP + R V+ L C G+ L Y +
Sbjct: 62 VAICLALISG-QLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGS-LAYNVL 119
Query: 762 LAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVIL 819
L +C ++AFK + EN+NEAKFI F M I W+ F+PI+ T Y + +
Sbjct: 120 LIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVS 179
Query: 820 ISNYG--ILYCTFIPKCYVIICKQEINTKS 847
+S G +L C F PK ++I+ + + N S
Sbjct: 180 VSLSGSVVLGCLFAPKLHIILFQPQKNVVS 209
>gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]
Length = 324
Score = 65.5 bits (158), Expect = 2e-10
Identities = 46/148 (31%), Positives = 69/148 (46%), Gaps = 4/148 (2%)
Query: 21 CQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHS 80
C + + T PG ++ GLF +H L P F + AM
Sbjct: 23 CHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLG 82
Query: 81 IEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139
+E INNST LLP + LGY++YD C++ + + ATLR LS + +E + D Y P
Sbjct: 83 VEEINNSTALLPNITLGYQLYDVCSD-SANVYATLRVLSL--PGQHHIELQGDLLHYSPT 139
Query: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQV 167
V AVIG + + +L+ L+P +
Sbjct: 140 VLAVIGPDSTNRAATTAALLSPFLVPML 167
Score = 35.0 bits (79), Expect = 0.32
Identities = 24/112 (21%), Positives = 47/112 (41%), Gaps = 1/112 (0%)
Query: 446 LLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPD 505
LL + V F ++ F+ + D + Y+++ W T T + I +
Sbjct: 167 LLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINE 226
Query: 506 QETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQT 557
+ + ++ + +S CS +C G + T H CC+EC C + N++
Sbjct: 227 TKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHH-CCFECVPCGAGTFLNKS 277
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 51.6 bits (122), Expect = 3e-06
Identities = 37/138 (26%), Positives = 58/138 (42%), Gaps = 17/138 (12%)
Query: 80 SIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPR 139
+IE I N +LL L +YDT + + A D Y P
Sbjct: 84 AIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFY-----------------DAIKYGPN 126
Query: 140 VKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAM 199
V G +T ++ L + Q+ + +T +L+DK ++P F RTVPSD A+
Sbjct: 127 HLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAI 186
Query: 200 AHLIQKSGWNWIGIITTD 217
L++ W +G +T D
Sbjct: 187 LKLLKHYQWKRVGTLTQD 204
>gi|8923705 G protein-coupled receptor, family C, group 5, member D
[Homo sapiens]
Length = 345
Score = 45.1 bits (105), Expect = 3e-04
Identities = 55/235 (23%), Positives = 99/235 (42%), Gaps = 32/235 (13%)
Query: 579 CFEKEVEYLNWNDS---LAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYV 635
C E +Y D+ I+L L++LGI+ +++ + F + S + +
Sbjct: 5 CIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQL 64
Query: 636 ILLCHFLNFASTSF-FIGEPQDFTCKTRQTMFGVSFTLCISCI------LTKSLKILLAF 688
+ L L +F FI E T R +FGV F LC SC+ L K ++ ++F
Sbjct: 65 LFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLVKLVRGCVSF 124
Query: 689 SFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGS 748
S+ L I C+ +Q++I T ++ T+ + + V + C+
Sbjct: 125 SWTTIL-----------CIAIGCSLLQIIIATEYV-----TLIMTRGMMFVNMTPCQLN- 167
Query: 749 ILAFGTMLGYIAILAFICFIFA---FKGKYENYNE-AKFITFGMLIYFIAWITFI 799
+ F +L Y+ L + F + F G EN+ + + I +L I W+ +I
Sbjct: 168 -VDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWI 221
>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
precursor [Homo sapiens]
Length = 899
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/122 (24%), Positives = 55/122 (45%), Gaps = 3/122 (2%)
Query: 136 YMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQ 195
Y +K ++ G S ++ V+ + + + Y S++ LS++ RFP+F RT PS
Sbjct: 172 YNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLH 231
Query: 196 IKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIE 255
L +K GW I I + L+ + + + I F++ +F SD +
Sbjct: 232 NPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQ---SFFSDPAVP 288
Query: 256 VR 257
V+
Sbjct: 289 VK 290
Score = 38.5 bits (88), Expect = 0.029
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 33/282 (11%)
Query: 590 NDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGG-----LRVCYVILLCHFLNF 644
+ L I + +LS LGI+ +V N + +++S V + L
Sbjct: 526 SQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPL 585
Query: 645 ASTSFFIGEPQ-DFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCL-- 701
+ IG Q F C+ R + G+ F+L + TK + F+ + +++ K L
Sbjct: 586 GLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEP 645
Query: 702 YRPILIIFTCTGIQVVICTLWLI----------FA--APTVEVNVS-LPRVIILECEEGS 748
++ + G+ V+ +W I FA P +++VS LP+ + C
Sbjct: 646 WKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQ--LEHCSSRK 703
Query: 749 ILAF-GTMLGYIAILAFICFIFAFKGK---YENYNEAKFITFGMLIYFIAWITFIPIYAT 804
+ + G GY +L + A++ K E N+ + + GM IY +A + I T
Sbjct: 704 MNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAV--GMAIYNVAVLCLITAPVT 761
Query: 805 TF----GKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQE 842
A + I+ S+Y L F+PK +I + E
Sbjct: 762 MILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGE 803
>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
precursor [Homo sapiens]
Length = 844
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/122 (24%), Positives = 55/122 (45%), Gaps = 3/122 (2%)
Query: 136 YMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQ 195
Y +K ++ G S ++ V+ + + + Y S++ LS++ RFP+F RT PS
Sbjct: 117 YNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLH 176
Query: 196 IKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIE 255
L +K GW I I + L+ + + + I F++ +F SD +
Sbjct: 177 NPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQ---SFFSDPAVP 233
Query: 256 VR 257
V+
Sbjct: 234 VK 235
Score = 38.5 bits (88), Expect = 0.029
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 33/282 (11%)
Query: 590 NDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGG-----LRVCYVILLCHFLNF 644
+ L I + +LS LGI+ +V N + +++S V + L
Sbjct: 471 SQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPL 530
Query: 645 ASTSFFIGEPQ-DFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCL-- 701
+ IG Q F C+ R + G+ F+L + TK + F+ + +++ K L
Sbjct: 531 GLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEP 590
Query: 702 YRPILIIFTCTGIQVVICTLWLI----------FA--APTVEVNVS-LPRVIILECEEGS 748
++ + G+ V+ +W I FA P +++VS LP+ + C
Sbjct: 591 WKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQ--LEHCSSRK 648
Query: 749 ILAF-GTMLGYIAILAFICFIFAFKGK---YENYNEAKFITFGMLIYFIAWITFIPIYAT 804
+ + G GY +L + A++ K E N+ + + GM IY +A + I T
Sbjct: 649 MNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAV--GMAIYNVAVLCLITAPVT 706
Query: 805 TF----GKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQE 842
A + I+ S+Y L F+PK +I + E
Sbjct: 707 MILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGE 748
>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
precursor [Homo sapiens]
Length = 961
Score = 44.7 bits (104), Expect = 4e-04
Identities = 30/122 (24%), Positives = 55/122 (45%), Gaps = 3/122 (2%)
Query: 136 YMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQ 195
Y +K ++ G S ++ V+ + + + Y S++ LS++ RFP+F RT PS
Sbjct: 234 YNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLH 293
Query: 196 IKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIE 255
L +K GW I I + L+ + + + I F++ +F SD +
Sbjct: 294 NPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQ---SFFSDPAVP 350
Query: 256 VR 257
V+
Sbjct: 351 VK 352
Score = 38.5 bits (88), Expect = 0.029
Identities = 63/282 (22%), Positives = 113/282 (40%), Gaps = 33/282 (11%)
Query: 590 NDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGG-----LRVCYVILLCHFLNF 644
+ L I + +LS LGI+ +V N + +++S V + L
Sbjct: 588 SQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPL 647
Query: 645 ASTSFFIGEPQ-DFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCL-- 701
+ IG Q F C+ R + G+ F+L + TK + F+ + +++ K L
Sbjct: 648 GLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEP 707
Query: 702 YRPILIIFTCTGIQVVICTLWLI----------FA--APTVEVNVS-LPRVIILECEEGS 748
++ + G+ V+ +W I FA P +++VS LP+ + C
Sbjct: 708 WKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQ--LEHCSSRK 765
Query: 749 ILAF-GTMLGYIAILAFICFIFAFKGK---YENYNEAKFITFGMLIYFIAWITFIPIYAT 804
+ + G GY +L + A++ K E N+ + + GM IY +A + I T
Sbjct: 766 MNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAV--GMAIYNVAVLCLITAPVT 823
Query: 805 TF----GKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQE 842
A + I+ S+Y L F+PK +I + E
Sbjct: 824 MILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGE 865
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 155 VSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGII 214
VS +P +G + I SDK SFLRTVP HQ +++ WN I ++
Sbjct: 107 VSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILL 166
Query: 215 TTDDDYGRLA---LNTFIIQAEA 234
+DD GR A L T + + E+
Sbjct: 167 VSDDHEGRAAQKRLETLLEERES 189
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 155 VSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGII 214
VS +P +G + I SDK SFLRTVP HQ +++ WN I ++
Sbjct: 107 VSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILL 166
Query: 215 TTDDDYGRLA---LNTFIIQAEA 234
+DD GR A L T + + E+
Sbjct: 167 VSDDHEGRAAQKRLETLLEERES 189
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 43.5 bits (101), Expect = 0.001
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 3/83 (3%)
Query: 155 VSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGII 214
VS +P +G + I SDK SFLRTVP HQ +++ WN I ++
Sbjct: 107 VSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILL 166
Query: 215 TTDDDYGRLA---LNTFIIQAEA 234
+DD GR A L T + + E+
Sbjct: 167 VSDDHEGRAAQKRLETLLEERES 189
>gi|7706451 G protein-coupled receptor, family C, group 5, member B
precursor [Homo sapiens]
Length = 403
Score = 38.5 bits (88), Expect = 0.029
Identities = 45/211 (21%), Positives = 87/211 (41%), Gaps = 30/211 (14%)
Query: 598 LILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDF 657
LI LL +I ++ + I + +PV GL ++ LL F T FI + +
Sbjct: 68 LITLLLMLILLVRLPFIKEKEKKSPV-----GLH--FLFLLGTLGLFGLTFAFIIQEDET 120
Query: 658 TCKTRQTMFGVSFTLCISCILTKSLKI--LLAFSFDP---KLQKFLKCLYRPILIIFTCT 712
C R+ ++GV F LC SC+L+++ ++ L+ P +L CL
Sbjct: 121 ICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLML--------- 171
Query: 713 GIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFK 772
+QV+I WL+ + + P + L + +L ++ +F
Sbjct: 172 -VQVIIAVEWLVLTV----LRDTRPACAYEPMDFVMALIYDMVL---LVVTLGLALFTLC 223
Query: 773 GKYENYN-EAKFITFGMLIYFIAWITFIPIY 802
GK++ + F+ + + W+ ++ +Y
Sbjct: 224 GKFKRWKLNGAFLLITAFLSVLIWVAWMTMY 254
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.138 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,331,074
Number of Sequences: 37866
Number of extensions: 1350127
Number of successful extensions: 4613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 4410
Number of HSP's gapped (non-prelim): 62
length of query: 926
length of database: 18,247,518
effective HSP length: 112
effective length of query: 814
effective length of database: 14,006,526
effective search space: 11401312164
effective search space used: 11401312164
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.