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Search of human proteins with 112789548
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112789548 lymphocyte-specific protein tyrosine kinase
precursor [Homo sapiens]
(509 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 1057 0.0
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 1057 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 685 0.0
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 674 0.0
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 674 0.0
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 634 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 586 e-167
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 583 e-166
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 569 e-162
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 566 e-161
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 566 e-161
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 553 e-157
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 553 e-157
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 553 e-157
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 510 e-144
gi|4503787 fyn-related kinase [Homo sapiens] 449 e-126
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 367 e-101
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 359 4e-99
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 359 4e-99
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 358 5e-99
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 358 5e-99
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 358 5e-99
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 358 5e-99
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 358 5e-99
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 345 6e-95
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 329 4e-90
gi|148596974 TXK tyrosine kinase [Homo sapiens] 328 9e-90
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 321 1e-87
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 316 3e-86
gi|187475373 c-src tyrosine kinase [Homo sapiens] 297 1e-80
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 1057 bits (2734), Expect = 0.0
Identities = 509/509 (100%), Positives = 509/509 (100%)
Query: 1 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
Sbjct: 1 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60
Query: 61 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
Sbjct: 61 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
Query: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
Sbjct: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180
Query: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
Sbjct: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240
Query: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
Sbjct: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300
Query: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
Sbjct: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
Query: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
Query: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
Query: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
Sbjct: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 1057 bits (2734), Expect = 0.0
Identities = 509/509 (100%), Positives = 509/509 (100%)
Query: 1 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
Sbjct: 1 MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60
Query: 61 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
Sbjct: 61 LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
Query: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
Sbjct: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180
Query: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
Sbjct: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240
Query: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
Sbjct: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300
Query: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
Sbjct: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
Query: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
Query: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
Query: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
Sbjct: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 685 bits (1768), Expect = 0.0
Identities = 324/448 (72%), Positives = 384/448 (85%)
Query: 62 QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
+D +V+AL+ YE H DL F+KG+Q+ +LE+SGEWWKA+SL T +EG+IP N+VA+ +S
Sbjct: 79 EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDS 138
Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
LE E WFFK +SRKDAERQLLAPGN GSF+IR+SE+T GS+SLSVRD+D QG+ VKHY
Sbjct: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHY 198
Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241
KIR LDNGGFYISPR TF L ELV HY +DGLC +LS PC + KPQKPW +D WE+P
Sbjct: 199 KIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP 258
Query: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301
RE+LKL ++LGAGQFGEVWM YN HTKVAVK++K GSMS +AFLAEAN+MK LQH +LV
Sbjct: 259 RESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLV 318
Query: 302 RLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYI 361
+L+AVVT+EPIYIITE+M GSL+DFLK+ G K + KL+D +AQIAEGMAFIE+RNYI
Sbjct: 319 KLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 378
Query: 362 HRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKS 421
HRDLRAANILVS +L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G+FTIKS
Sbjct: 379 HRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKS 438
Query: 422 DVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERP 481
DVWSFGILL EIVT+GRIPYPGM+NPEVI+ LERGYRM RP+NCPEELY +M CWK RP
Sbjct: 439 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRP 498
Query: 482 EDRPTFDYLRSVLEDFFTATEGQYQPQP 509
E+RPTF+Y++SVL+DF+TATE QYQ QP
Sbjct: 499 EERPTFEYIQSVLDDFYTATESQYQQQP 526
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 674 bits (1739), Expect = 0.0
Identities = 323/480 (67%), Positives = 394/480 (82%), Gaps = 14/480 (2%)
Query: 44 VRDPLVTYEGSNPPASPL-------------QDNLVIALHSYEPSHDGDLGFEKGEQLRI 90
VRDP + P S L Q ++V+AL+ Y+ H DL F+KGE++++
Sbjct: 33 VRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKV 92
Query: 91 LEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGS 150
LE+ GEWWKA+SL T +EGFIP N+VAK N+LE E WFFK+++RKDAERQLLAPGN+ G+
Sbjct: 93 LEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGA 152
Query: 151 FLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYT 210
FLIRESE+ GSFSLSVRDFD G+V+KHYKIR+LDNGG+YISPRITFP + ++++HY
Sbjct: 153 FLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQ 212
Query: 211 NASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV 270
+DGLC RL + C + KPQKPW +D WE+PRE++KLV+RLGAGQFGEVWMGYYN TKV
Sbjct: 213 KQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 272
Query: 271 AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK 329
AVK+LK G+MS AFL EANLMK LQH +LVRLYAVVT +EPIYIITEYM GSL+DFLK
Sbjct: 273 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK 332
Query: 330 TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI 389
+ G K+ + KL+D +AQIAEGMA+IE +NYIHRDLRAAN+LVS++L CKIADFGLAR+I
Sbjct: 333 SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI 392
Query: 390 EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEV 449
EDNEYTAREGAKFPIKWTAPEAIN+G FTIKSDVWSFGILL EIVT+G+IPYPG TN +V
Sbjct: 393 EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADV 452
Query: 450 IQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
+ L +GYRM R +NCP+ELY +M++CWKE+ E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 453 MTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 674 bits (1738), Expect = 0.0
Identities = 316/449 (70%), Positives = 386/449 (85%), Gaps = 1/449 (0%)
Query: 62 QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
Q ++V+AL+ Y+ H DL F+KGE++++LE+ GEWWKA+SL T +EGFIP N+VAK N+
Sbjct: 43 QGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNT 102
Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
LE E WFFK+++RKDAERQLLAPGN+ G+FLIRESE+ GSFSLSVRDFD G+V+KHY
Sbjct: 103 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHY 162
Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241
KIR+LDNGG+YISPRITFP + ++++HY +DGLC RL + C + KPQKPW +D WE+P
Sbjct: 163 KIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIP 222
Query: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301
RE++KLV+RLGAGQFGEVWMGYYN TKVAVK+LK G+MS AFL EANLMK LQH +LV
Sbjct: 223 RESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV 282
Query: 302 RLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
RLYAVVT +EPIYIITEYM GSL+DFLK+ G K+ + KL+D +AQIAEGMA+IE +NY
Sbjct: 283 RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNY 342
Query: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
IHRDLRAAN+LVS++L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G FTIK
Sbjct: 343 IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 402
Query: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
SDVWSFGILL EIVT+G+IPYPG TN +V+ L +GYRM R +NCP+ELY +M++CWKE+
Sbjct: 403 SDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK 462
Query: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 463 AEERPTFDYLQSVLDDFYTATEGQYQQQP 491
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 634 bits (1634), Expect = 0.0
Identities = 305/470 (64%), Positives = 382/470 (81%), Gaps = 11/470 (2%)
Query: 47 PLVTYEGSNPPASPLQDNL------VIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100
PLV + PP P ++L V+AL+ Y +D DL KGE+L++L+ +G+WW A
Sbjct: 40 PLVVFNHLTPP--PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLA 97
Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
+SL TG+EG++P NFVA+ SLE E WFF++ RK+AERQLLAP N GSFLIRESE+
Sbjct: 98 RSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNK 157
Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
G+FSLSV+D QGE++KHYKIR LD GG+YISPRITFP L LV+HY+ DGLC RL
Sbjct: 158 GAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRL 216
Query: 221 SRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
+ PC PQ PW +DEWE+PR++L+LV +LG+GQFGEVWMGYY + KVA+K+LK+G+M
Sbjct: 217 TLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTM 276
Query: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
SP+AFL EAN+MK LQH+RLVRLYAVVT+EPIYI+TEYM G L+DFLKT G +L++ +
Sbjct: 277 SPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336
Query: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
L+DM+AQIAEGMA+IE N IHRDLRAANILVS+ L CKIADFGLAR+I D+EYTA+EGA
Sbjct: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGA 395
Query: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
KFPIKWTAPEAI++G FTIK+DVWSFG+LL E+VT+GR+PYPGM+NPEVI+NLERGYRM
Sbjct: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455
Query: 461 RPDNCPEELYQ-LMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
RPD CP ELY+ ++ CW+ RPE+RPTF++L+SVLEDF+TATE QY+ QP
Sbjct: 456 RPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 586 bits (1510), Expect = e-167
Identities = 282/448 (62%), Positives = 355/448 (79%), Gaps = 5/448 (1%)
Query: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ----KPWWEDEWE 239
R LDNGG+YI+ R F L +LV+HY+ + GLC RL PC P+ +D WE
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265
Query: 240 VPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQR 299
+PRE+L+L++RLG GQFGEVWMG +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +
Sbjct: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325
Query: 300 LVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
LV+LYAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE N
Sbjct: 326 LVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 385
Query: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
YIHRDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTI
Sbjct: 386 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 445
Query: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
KSDVWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+
Sbjct: 446 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 505
Query: 480 RPEDRPTFDYLRSVLEDFFTATEGQYQP 507
PE+RPTF+YL+S LED+FTATE QYQP
Sbjct: 506 DPEERPTFEYLQSFLEDYFTATEPQYQP 533
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 583 bits (1503), Expect = e-166
Identities = 277/445 (62%), Positives = 353/445 (79%), Gaps = 2/445 (0%)
Query: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
+ +AL+ YE DL F+KGE+ +I+ + G+WW+A+S+ TG+ G+IP N+VA A+S++
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154
Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
E W+F + RKDAER LL PGN G FL+RESE+T G++SLS+RD+D+ +G+ VKHYKI
Sbjct: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214
Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
R LDNGG+YI+ R F L +LV+HYT +DGLC +L+ C T KPQ +D WE+PR
Sbjct: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274
Query: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
E+L+L +LG G FGEVWMG +NG TKVA+K+LK G+M P+AFL EA +MK+L+H +LV
Sbjct: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334
Query: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
LYAVV++EPIYI+TE+M GSL+DFLK G L + +L+DMAAQIA+GMA+IE NYIH
Sbjct: 335 LYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIH 394
Query: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
RDLRAANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSD
Sbjct: 395 RDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 454
Query: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
VWSFGIL TE+VT GR+PYPGM N EV++ +ERGYRM P CPE L++LM LCWK+ P+
Sbjct: 455 VWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 514
Query: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
+RPTF+Y++S LED+FTATE QYQP
Sbjct: 515 ERPTFEYIQSFLEDYFTATEPQYQP 539
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 569 bits (1466), Expect = e-162
Identities = 276/445 (62%), Positives = 349/445 (78%), Gaps = 2/445 (0%)
Query: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
R LDNGG+YI+ R F L +LV+HY+ +DGLC L+ + PQ +D WEV R
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265
Query: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
+L L ++LG G F EVW+G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+
Sbjct: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325
Query: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
LYAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE NYIH
Sbjct: 326 LYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 385
Query: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
RDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSD
Sbjct: 386 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 445
Query: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
VWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+ PE
Sbjct: 446 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 505
Query: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
+RPTF+YL+S LED+FTATE QYQP
Sbjct: 506 ERPTFEYLQSFLEDYFTATEPQYQP 530
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 566 bits (1459), Expect = e-161
Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)
Query: 58 ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114
A PL + +AL+ YE + DL F+KGE+L+I+ + G+WW A SL+TGQ G+IP N
Sbjct: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
Query: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174
+VA ++S++ E W+F ++R+++ER LL N G+FL+RESE+T G++ LSV DFD +
Sbjct: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
Query: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234
G VKHYKIR LD+GGFYI+ R F L +LV +Y+ +DGLC RL+ C T KPQ
Sbjct: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258
Query: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293
+D WE+PRE+L+L +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
Query: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
+L+H++LV+LYAVV++EPIYI+TEYM GSL+DFLK +G L + +L+DMAAQIA GMA
Sbjct: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378
Query: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
++E NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA
Sbjct: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
Query: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+ +ERGYRM P CPE L+ LM
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498
Query: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 566 bits (1459), Expect = e-161
Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)
Query: 58 ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114
A PL + +AL+ YE + DL F+KGE+L+I+ + G+WW A SL+TGQ G+IP N
Sbjct: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
Query: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174
+VA ++S++ E W+F ++R+++ER LL N G+FL+RESE+T G++ LSV DFD +
Sbjct: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
Query: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234
G VKHYKIR LD+GGFYI+ R F L +LV +Y+ +DGLC RL+ C T KPQ
Sbjct: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258
Query: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293
+D WE+PRE+L+L +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
Query: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
+L+H++LV+LYAVV++EPIYI+TEYM GSL+DFLK +G L + +L+DMAAQIA GMA
Sbjct: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378
Query: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
++E NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA
Sbjct: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
Query: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+ +ERGYRM P CPE L+ LM
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498
Query: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 553 bits (1426), Expect = e-157
Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)
Query: 42 SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100
S+ +P G+ S + L IAL+ YE + DL F KGE+ IL + G+WW+A
Sbjct: 58 SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
+SL++G+ G IP N+VA +S++ E W+F + RKDAERQLL+PGN G+FLIRESE+T
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F + ELV+HY +DGLC L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
Query: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279
PC KPQ +D WE+ R ++ L RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
Query: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339
MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G L +
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
+L+DMAAQ+AEGMA++E NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY +G
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
+KFPIKWTAPEA +G FTIKSDVWSFGILLTE++T GRIPYPGM EV++ +E+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
P CP LY+ M W+ PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 553 bits (1426), Expect = e-157
Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)
Query: 42 SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100
S+ +P G+ S + L IAL+ YE + DL F KGE+ IL + G+WW+A
Sbjct: 58 SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
+SL++G+ G IP N+VA +S++ E W+F + RKDAERQLL+PGN G+FLIRESE+T
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F + ELV+HY +DGLC L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
Query: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279
PC KPQ +D WE+ R ++ L RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
Query: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339
MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G L +
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
+L+DMAAQ+AEGMA++E NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY +G
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
+KFPIKWTAPEA +G FTIKSDVWSFGILLTE++T GRIPYPGM EV++ +E+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
P CP LY+ M W+ PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 553 bits (1426), Expect = e-157
Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)
Query: 42 SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100
S+ +P G+ S + L IAL+ YE + DL F KGE+ IL + G+WW+A
Sbjct: 58 SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
+SL++G+ G IP N+VA +S++ E W+F + RKDAERQLL+PGN G+FLIRESE+T
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F + ELV+HY +DGLC L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
Query: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279
PC KPQ +D WE+ R ++ L RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
Query: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339
MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G L +
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
+L+DMAAQ+AEGMA++E NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY +G
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
+KFPIKWTAPEA +G FTIKSDVWSFGILLTE++T GRIPYPGM EV++ +E+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
P CP LY+ M W+ PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 510 bits (1314), Expect = e-144
Identities = 255/444 (57%), Positives = 320/444 (72%), Gaps = 52/444 (11%)
Query: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
L +AL+ YE + DL F KGE+ +IL S G+WW+A+SLTTG+ G+IP N+VA +S++
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145
Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
E W+F L RKDAERQLL+ GN G+FLIRESE+T G++SLS+RD+D +G+ VKHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205
Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243
R LDNGG+YI+ R F L +LV+HY+
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232
Query: 244 TLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRL 303
G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+L
Sbjct: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274
Query: 304 YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 363
YAVV++EPIYI+TEYM GSL+DFLK G L + L+DMAAQ+A GMA+IE NYIHR
Sbjct: 275 YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 334
Query: 364 DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV 423
DLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSDV
Sbjct: 335 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 394
Query: 424 WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPED 483
WSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM P +CP L++LM CWK+ PE+
Sbjct: 395 WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE 454
Query: 484 RPTFDYLRSVLEDFFTATEGQYQP 507
RPTF+YL+S LED+FTATE QYQP
Sbjct: 455 RPTFEYLQSFLEDYFTATEPQYQP 478
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 449 bits (1155), Expect = e-126
Identities = 233/466 (50%), Positives = 314/466 (67%), Gaps = 23/466 (4%)
Query: 57 PASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGE-WWKAQSLTTGQEG------ 109
P S + +AL Y+ DL F G++L++L+ E WW A+ L ++G
Sbjct: 38 PQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQ 97
Query: 110 -FIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVR 168
+IP N+VA+ SL+ EPWFF + R DAE+QLL N GSFLIRESES G FSLSV
Sbjct: 98 GYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL 157
Query: 169 DFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQK 228
D G VVKHY+I+ LD GGF+++ R F L+E V HYT SDGLC +L +PC +
Sbjct: 158 D-----GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQ 212
Query: 229 PQKPW-----WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD 283
P+ D+WE+ R +++L++RLG+GQFGEVW G +N T VAVK+LK GSM P+
Sbjct: 213 VPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN 272
Query: 284 AFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLL 342
FL EA +MK L+H +L++LYAV T ++PIYIITE M +GSL ++L+ +G K+ + + +
Sbjct: 273 DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV 332
Query: 343 DMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNE--YTAREG 399
DMAAQ+A GMA++E RNYIHRDL A N+LV + K+ADFGLAR+ + DNE Y +R
Sbjct: 333 DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE 392
Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
K P+KWTAPEAI F+IKSDVWSFGILL EI+T+G++PY GMT +VIQ L + YR+
Sbjct: 393 IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRL 452
Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQY 505
+P NCP++ Y +M CW P++RPTF+ LR LED+F T+ Y
Sbjct: 453 PQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 367 bits (941), Expect = e-101
Identities = 201/454 (44%), Positives = 278/454 (61%), Gaps = 17/454 (3%)
Query: 46 DPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTT 105
DP+ T P SP L +AL+ + G+L +G++L LE+ G + A+ L+
Sbjct: 39 DPVPTLPAE--PCSPFPQ-LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLS- 94
Query: 106 GQE--GFIPFNFVAKAN--SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAG 161
GQ G +P VAKA+ +L +PW+F +SR A++ LL+P N G+FLIR SES+ G
Sbjct: 95 GQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLG 154
Query: 162 SFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLS 221
+SLSVR Q +V HY++ +G Y+ FPGL EL+ +Y + L
Sbjct: 155 GYSLSVRA----QAKVC-HYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL 209
Query: 222 RPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMS 281
+PC QK + +D WE P L +LG G FGEVW G + G VA+K +K +M
Sbjct: 210 QPCMPQKAPR---QDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMK 266
Query: 282 PDAFLAEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
E +K L+H+RL+RL+AV + EP+YI+TE M G+L FL TP G L +
Sbjct: 267 LTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPP 326
Query: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
LL A Q+AEGM+++EE+ +HRDL A N+LV D L+CK+ADFGLARL++D+ Y+ +
Sbjct: 327 LLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSS 386
Query: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
K P+KWTAPEA NY F+ KSDVWSFG+LL E+ T+G+ PY GMTN E +Q + RGYR+
Sbjct: 387 KIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLP 446
Query: 461 RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVL 494
RP CP E+Y LM CW+ PE+RP+F LR L
Sbjct: 447 RPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 359 bits (921), Expect = 4e-99
Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 17/443 (3%)
Query: 64 NLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
NL +AL+ + S D L KGE+LR+L +GEW +AQ T +G++P N++ NS
Sbjct: 64 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNS 121
Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
LE W+ +SR AE LL+ G +GSFL+RESES+ G S+S+R +G V HY
Sbjct: 122 LEKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HY 174
Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE----DE 237
+I +G Y+S F L ELV H++ +DGL T L P + + D+
Sbjct: 175 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 234
Query: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAEANLMKQLQ 296
WE+ R + + +LG GQ+GEV+ G + ++ VAVK+LK+ +M + FL EA +MK+++
Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 294
Query: 297 HQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 355
H LV+L V T+EP YIITE+M G+L+D+L+ + ++ LL MA QI+ M ++
Sbjct: 295 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 354
Query: 356 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG 415
E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWTAPE++ Y
Sbjct: 355 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 414
Query: 416 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL 475
F+IKSDVW+FG+LL EI T+G PYPG+ +V + LE+ YRM RP+ CPE++Y+LMR
Sbjct: 415 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 474
Query: 476 CWKERPEDRPTFDYLRSVLEDFF 498
CW+ P DRP+F + E F
Sbjct: 475 CWQWNPSDRPSFAEIHQAFETMF 497
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 359 bits (921), Expect = 4e-99
Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 17/443 (3%)
Query: 64 NLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
NL +AL+ + S D L KGE+LR+L +GEW +AQ T +G++P N++ NS
Sbjct: 83 NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNS 140
Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
LE W+ +SR AE LL+ G +GSFL+RESES+ G S+S+R +G V HY
Sbjct: 141 LEKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HY 193
Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE----DE 237
+I +G Y+S F L ELV H++ +DGL T L P + + D+
Sbjct: 194 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 253
Query: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAEANLMKQLQ 296
WE+ R + + +LG GQ+GEV+ G + ++ VAVK+LK+ +M + FL EA +MK+++
Sbjct: 254 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 313
Query: 297 HQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 355
H LV+L V T+EP YIITE+M G+L+D+L+ + ++ LL MA QI+ M ++
Sbjct: 314 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 373
Query: 356 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG 415
E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWTAPE++ Y
Sbjct: 374 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 433
Query: 416 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL 475
F+IKSDVW+FG+LL EI T+G PYPG+ +V + LE+ YRM RP+ CPE++Y+LMR
Sbjct: 434 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 493
Query: 476 CWKERPEDRPTFDYLRSVLEDFF 498
CW+ P DRP+F + E F
Sbjct: 494 CWQWNPSDRPSFAEIHQAFETMF 516
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 358 bits (920), Expect = 5e-99
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 89 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 146
Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 200
Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 201 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 257
Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 258 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 317
Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 318 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 377
Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 437
Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 438 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 497
Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
++Y+LMR CWK P DRP+F E F
Sbjct: 498 KVYELMRACWKWSPADRPSFAETHQAFETMF 528
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 358 bits (920), Expect = 5e-99
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 104 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 161
Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 215
Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 216 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 272
Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 273 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 332
Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 333 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 392
Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 393 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 452
Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 453 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512
Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
++Y+LMR CWK P DRP+F E F
Sbjct: 513 KVYELMRACWKWSPADRPSFAETHQAFETMF 543
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 358 bits (920), Expect = 5e-99
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 83 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 140
Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 141 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 194
Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 195 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 251
Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 252 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 311
Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 312 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 371
Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 372 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 431
Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 432 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 491
Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
++Y+LMR CWK P DRP+F E F
Sbjct: 492 KVYELMRACWKWSPADRPSFAETHQAFETMF 522
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 358 bits (920), Expect = 5e-99
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 89 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 146
Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 200
Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 201 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 257
Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 258 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 317
Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 318 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 377
Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 437
Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 438 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 497
Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
++Y+LMR CWK P DRP+F E F
Sbjct: 498 KVYELMRACWKWSPADRPSFAETHQAFETMF 528
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 358 bits (920), Expect = 5e-99
Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)
Query: 58 ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
A+ NL +AL+ + S D L KGE+LR+L Q+GEW + +S +G++P N+
Sbjct: 68 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 125
Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
+ NSLE W+ +SR AE L + N GSFL+RESES+ G S+S+R +G
Sbjct: 126 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 179
Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
V HY+I +G Y++ F L ELV H++ +DGL T L P K KP
Sbjct: 180 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 236
Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
D+WE+ R + + +LG GQ+GEV++G + ++ VAVK+LK+ +M + FL E
Sbjct: 237 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 296
Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
A +MK+++H LV+L V T EP YI+TEYM G+L+D+L+ + ++T LL MA Q
Sbjct: 297 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 356
Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
I+ M ++E++N+IHRDL A N LV + K+ADFGL+RL+ + YTA GAKFPIKWT
Sbjct: 357 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 416
Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
APE++ Y TF+IKSDVW+FG+LL EI T+G PYPG+ +V LE+GYRM +P+ CP
Sbjct: 417 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 476
Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
++Y+LMR CWK P DRP+F E F
Sbjct: 477 KVYELMRACWKWSPADRPSFAETHQAFETMF 507
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 345 bits (885), Expect = 6e-95
Identities = 181/438 (41%), Positives = 268/438 (61%), Gaps = 14/438 (3%)
Query: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTG----QEGFIPFNFVAKANSL 122
+ L ++ D +L F G+ + + +WW A L +G++P N++A+ ++
Sbjct: 14 VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73
Query: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
E EPWFF +SR +A R+L A GN G+FLIR SE + + LSVRD + V+HYK
Sbjct: 74 ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT-----QAVRHYK 128
Query: 183 IRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQK-PWWEDEWEVP 241
I G +++ ++F L ELV ++ S RL+ PC+ +P+ P W+D WE P
Sbjct: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDD-WERP 187
Query: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL-AEANLMKQLQHQRL 300
RE L +LG+G FGEV+ G + +VA+K + + ++ L +E MK+L+H+ +
Sbjct: 188 REEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247
Query: 301 VRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
+ LYAVV+ +P+YIITE M GSL++ L+ L +++LLD+A Q+AEGM ++E +N
Sbjct: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307
Query: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
YIHRDL A NILV + CK+ DFGLARLI+++ Y + + P KWTAPEA++ G ++
Sbjct: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYST 366
Query: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
KSDVWSFGILL E+ + G++PYPGM+N E ++ GYRM P CP +++LM CW
Sbjct: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426
Query: 480 RPEDRPTFDYLRSVLEDF 497
PE RP F LR L F
Sbjct: 427 DPEQRPCFKALRERLSSF 444
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 329 bits (843), Expect = 4e-90
Identities = 176/455 (38%), Positives = 277/455 (60%), Gaps = 16/455 (3%)
Query: 52 EGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGF 110
E + P S + V+AL+ Y P + DL KG++ ILE+S WW+A+ GQEG+
Sbjct: 205 EPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGY 263
Query: 111 IPFNFVAKA-NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRD 169
IP N+V +A +S+E W+ K+++R AE QLL G F++R+S S AG +++SV
Sbjct: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDS-SKAGKYTVSV-- 319
Query: 170 FDQNQGE---VVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQT 226
F ++ G+ V++HY + + +Y++ + F + EL+ ++ + S GL +RL P
Sbjct: 320 FAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQ 379
Query: 227 QKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP 282
Q P WE+ + L ++ LG GQFG V G + G VA+K +K+GSMS
Sbjct: 380 QNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE 439
Query: 283 DAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKL 341
D F+ EA +M L H++LV+LY V T Q PI+IITEYM NG L+++L+ + +L
Sbjct: 440 DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQL 498
Query: 342 LDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAK 401
L+M + E M ++E + ++HRDL A N LV+D K++DFGL+R + D+EYT+ G+K
Sbjct: 499 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 558
Query: 402 FPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVR 461
FP++W+ PE + Y F+ KSD+W+FG+L+ EI + G++PY TN E +++ +G R+ R
Sbjct: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618
Query: 462 PDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 496
P E++Y +M CW E+ ++RPTF L S + D
Sbjct: 619 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILD 653
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 328 bits (840), Expect = 9e-90
Identities = 175/451 (38%), Positives = 276/451 (61%), Gaps = 15/451 (3%)
Query: 56 PPASPLQDNLVI-ALHSYEPSHDGDLGFEKGEQLRILEQ-SGEWWKAQSLTTGQEGFIPF 113
PP+ ++ + + AL+ + P +L + E+ ILE+ + WWKA+ G EG IP
Sbjct: 76 PPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPS 134
Query: 114 NFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFD 171
N+V K +LE W+ +N++R AE LL + G+F++R+S GS+++SV
Sbjct: 135 NYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGA 192
Query: 172 QNQGEV-VKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ 230
+ E +KHY+I+ D+G +Y++ R F + EL+ ++ + + GL TRL P
Sbjct: 193 RRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSC 252
Query: 231 KP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL 286
P + ++WE+ L ++ +G+GQFG V +G + H +VA+K++ +GSMS + F+
Sbjct: 253 LPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFI 312
Query: 287 AEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMA 345
EA +M +L H +LV+LY V Q +P+YI+TE+MENG L+++L+ G KL LL +
Sbjct: 313 EEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVC 371
Query: 346 AQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIK 405
I EGM ++E YIHRDL A N LVS T KI+DFG+ R + D+EY + GAKFPIK
Sbjct: 372 QDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIK 431
Query: 406 WTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNC 465
W+ PE + ++ KSDVWSFG+L+ E+ T G++P+ +N +V++ + G+R+ RP
Sbjct: 432 WSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLA 491
Query: 466 PEELYQLMRLCWKERPEDRPTF-DYLRSVLE 495
P +Y++M CW E+PE RPTF + LR+V E
Sbjct: 492 PMSIYEVMYSCWHEKPEGRPTFAELLRAVTE 522
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 321 bits (822), Expect = 1e-87
Identities = 169/463 (36%), Positives = 279/463 (60%), Gaps = 20/463 (4%)
Query: 56 PPASPLQDN-----LVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEG 109
PP PL++ +V+A++ ++ + DL E+G++ ILE++ WW+A+ G EG
Sbjct: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEG 227
Query: 110 FIPFNFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV 167
+IP N+V K+N+L+ W+ +N++R AE QLL + G F++R+S S G +++S+
Sbjct: 228 YIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSL 285
Query: 168 -RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSRPC 224
F +HY I+ +Y++ + F + E++ ++ + + GL TRL P
Sbjct: 286 YTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPV 345
Query: 225 QTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
+ P + ++WE+ L + LG+G FG V +G + KVA+K++++G+M
Sbjct: 346 SVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM 405
Query: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTIN 339
+ F+ EA +M +L H +LV+LY V TQ+ PIYI+TE+ME G L++FL+ G + +
Sbjct: 406 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRD 464
Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
LL M + EGM ++E ++IHRDL A N LVS+ K++DFG+AR + D++YT+ G
Sbjct: 465 VLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSG 524
Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
AKFP+KW PE NY F+ KSDVWSFG+L+ E+ T GR+P+ TN EV+ + RG+R+
Sbjct: 525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRL 584
Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATE 502
+P +Y++M CW+E+PE RP+F+ L +++ E
Sbjct: 585 YQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 316 bits (810), Expect = 3e-86
Identities = 164/453 (36%), Positives = 271/453 (59%), Gaps = 16/453 (3%)
Query: 50 TYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQE 108
T E + P ++ +VIAL+ Y+ + +L + E+ +L+ S WW+ Q G E
Sbjct: 160 TPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHE 218
Query: 109 GFIPFNFVAKA--NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLS 166
G++P +++ + N+LE W+ K++SR AE+ LL G G+F++R+S TAG++++S
Sbjct: 219 GYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSR-TAGTYTVS 276
Query: 167 V--RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSR 222
V + +KHY I+ ++ +Y++ + F + L+ ++ + GL TRL
Sbjct: 277 VFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRY 336
Query: 223 PCQTQKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQG 278
P + + P +W + L V+ +G+GQFG V +GY+ KVA+K++++G
Sbjct: 337 PVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREG 396
Query: 279 SMSPDAFLAEANLMKQLQHQRLVRLYAV-VTQEPIYIITEYMENGSLVDFLKTPSGIKLT 337
+MS + F+ EA +M +L H +LV+LY V + Q PI ++ E+ME+G L D+L+T G+
Sbjct: 397 AMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FA 455
Query: 338 INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAR 397
LL M + EGMA++EE IHRDL A N LV + K++DFG+ R + D++YT+
Sbjct: 456 AETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS 515
Query: 398 EGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGY 457
G KFP+KW +PE ++ ++ KSDVWSFG+L+ E+ + G+IPY +N EV++++ G+
Sbjct: 516 TGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGF 575
Query: 458 RMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL 490
R+ +P +YQ+M CWKERPEDRP F L
Sbjct: 576 RLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 297 bits (761), Expect = 1e-80
Identities = 177/446 (39%), Positives = 260/446 (58%), Gaps = 28/446 (6%)
Query: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGE--WWKAQSLTTGQEGFIPFNFVAK------ 118
IA +++ + + DL F KG+ L I+ + + W+KA++ G+EG IP N+V K
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
Query: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
L PWF ++R+ AER L P G FL+RES + G ++L V + V
Sbjct: 74 GTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGK-----V 126
Query: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWE 235
+HY+I I + F L +LV HYT+ +DGLCTRL +P T Q ++
Sbjct: 127 EHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYR 185
Query: 236 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL 295
W + + LKL++ +G G+FG+V +G Y G+ KVAVK +K + + AFLAEA++M QL
Sbjct: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQL 243
Query: 296 QHQRLVRLYAVVTQEP--IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
+H LV+L V+ +E +YI+TEYM GSLVD+L++ L + LL + + E M
Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
Query: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
++E N++HRDL A N+LVS+ K++DFGL + + T K P+KWTAPEA+
Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359
Query: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
F+ KSDVWSFGILL EI + GR+PYP + +V+ +E+GY+M PD CP +Y++M
Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
Query: 474 RLCWKERPEDRPTFDYLRSVLEDFFT 499
+ CW RP+F LR LE T
Sbjct: 420 KNCWHLDAAMRPSFLQLREQLEHIKT 445
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,116,685
Number of Sequences: 37866
Number of extensions: 994557
Number of successful extensions: 4364
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 701
Number of HSP's successfully gapped in prelim test: 267
Number of HSP's that attempted gapping in prelim test: 2097
Number of HSP's gapped (non-prelim): 1162
length of query: 509
length of database: 18,247,518
effective HSP length: 107
effective length of query: 402
effective length of database: 14,195,856
effective search space: 5706734112
effective search space used: 5706734112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.