Guide to the Human Genome
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Search of human proteins with 112789546

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112789546 lymphocyte-specific protein tyrosine kinase
precursor [Homo sapiens]
         (509 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...  1057   0.0  
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...  1057   0.0  
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     685   0.0  
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   674   0.0  
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   674   0.0  
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 634   0.0  
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       586   e-167
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              583   e-166
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      569   e-162
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   566   e-161
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   566   e-161
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   553   e-157
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   553   e-157
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   553   e-157
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      510   e-144
gi|4503787 fyn-related kinase [Homo sapiens]                          449   e-126
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   367   e-101
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   359   4e-99
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   359   4e-99
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             358   5e-99
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               358   5e-99
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             358   5e-99
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             358   5e-99
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             358   5e-99
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]              345   6e-95
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   329   4e-90
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       328   9e-90
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               321   1e-87
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                316   3e-86
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     297   1e-80

>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score = 1057 bits (2734), Expect = 0.0
 Identities = 509/509 (100%), Positives = 509/509 (100%)

Query: 1   MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60
           MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
Sbjct: 1   MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60

Query: 61  LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
Sbjct: 61  LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120

Query: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180
           SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
Sbjct: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180

Query: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240
           YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
Sbjct: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240

Query: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300
           PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
Sbjct: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300

Query: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
           VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
Sbjct: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360

Query: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
           IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420

Query: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
           SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480

Query: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
           PEDRPTFDYLRSVLEDFFTATEGQYQPQP
Sbjct: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score = 1057 bits (2734), Expect = 0.0
 Identities = 509/509 (100%), Positives = 509/509 (100%)

Query: 1   MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60
           MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
Sbjct: 1   MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP 60

Query: 61  LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
Sbjct: 61  LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120

Query: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180
           SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
Sbjct: 121 SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH 180

Query: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240
           YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
Sbjct: 181 YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV 240

Query: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300
           PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
Sbjct: 241 PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL 300

Query: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
           VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
Sbjct: 301 VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360

Query: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
           IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
Sbjct: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420

Query: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
           SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
Sbjct: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480

Query: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
           PEDRPTFDYLRSVLEDFFTATEGQYQPQP
Sbjct: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  685 bits (1768), Expect = 0.0
 Identities = 324/448 (72%), Positives = 384/448 (85%)

Query: 62  QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
           +D +V+AL+ YE  H  DL F+KG+Q+ +LE+SGEWWKA+SL T +EG+IP N+VA+ +S
Sbjct: 79  EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDS 138

Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
           LE E WFFK +SRKDAERQLLAPGN  GSF+IR+SE+T GS+SLSVRD+D  QG+ VKHY
Sbjct: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHY 198

Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241
           KIR LDNGGFYISPR TF  L ELV HY   +DGLC +LS PC + KPQKPW +D WE+P
Sbjct: 199 KIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIP 258

Query: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301
           RE+LKL ++LGAGQFGEVWM  YN HTKVAVK++K GSMS +AFLAEAN+MK LQH +LV
Sbjct: 259 RESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLV 318

Query: 302 RLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYI 361
           +L+AVVT+EPIYIITE+M  GSL+DFLK+  G K  + KL+D +AQIAEGMAFIE+RNYI
Sbjct: 319 KLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI 378

Query: 362 HRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKS 421
           HRDLRAANILVS +L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G+FTIKS
Sbjct: 379 HRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKS 438

Query: 422 DVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERP 481
           DVWSFGILL EIVT+GRIPYPGM+NPEVI+ LERGYRM RP+NCPEELY +M  CWK RP
Sbjct: 439 DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRP 498

Query: 482 EDRPTFDYLRSVLEDFFTATEGQYQPQP 509
           E+RPTF+Y++SVL+DF+TATE QYQ QP
Sbjct: 499 EERPTFEYIQSVLDDFYTATESQYQQQP 526


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  674 bits (1739), Expect = 0.0
 Identities = 323/480 (67%), Positives = 394/480 (82%), Gaps = 14/480 (2%)

Query: 44  VRDPLVTYEGSNPPASPL-------------QDNLVIALHSYEPSHDGDLGFEKGEQLRI 90
           VRDP    +    P S L             Q ++V+AL+ Y+  H  DL F+KGE++++
Sbjct: 33  VRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKV 92

Query: 91  LEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGS 150
           LE+ GEWWKA+SL T +EGFIP N+VAK N+LE E WFFK+++RKDAERQLLAPGN+ G+
Sbjct: 93  LEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGA 152

Query: 151 FLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYT 210
           FLIRESE+  GSFSLSVRDFD   G+V+KHYKIR+LDNGG+YISPRITFP + ++++HY 
Sbjct: 153 FLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQ 212

Query: 211 NASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV 270
             +DGLC RL + C + KPQKPW +D WE+PRE++KLV+RLGAGQFGEVWMGYYN  TKV
Sbjct: 213 KQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 272

Query: 271 AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK 329
           AVK+LK G+MS  AFL EANLMK LQH +LVRLYAVVT +EPIYIITEYM  GSL+DFLK
Sbjct: 273 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK 332

Query: 330 TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI 389
           +  G K+ + KL+D +AQIAEGMA+IE +NYIHRDLRAAN+LVS++L CKIADFGLAR+I
Sbjct: 333 SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI 392

Query: 390 EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEV 449
           EDNEYTAREGAKFPIKWTAPEAIN+G FTIKSDVWSFGILL EIVT+G+IPYPG TN +V
Sbjct: 393 EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADV 452

Query: 450 IQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
           +  L +GYRM R +NCP+ELY +M++CWKE+ E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 453 MTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  674 bits (1738), Expect = 0.0
 Identities = 316/449 (70%), Positives = 386/449 (85%), Gaps = 1/449 (0%)

Query: 62  QDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
           Q ++V+AL+ Y+  H  DL F+KGE++++LE+ GEWWKA+SL T +EGFIP N+VAK N+
Sbjct: 43  QGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNT 102

Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
           LE E WFFK+++RKDAERQLLAPGN+ G+FLIRESE+  GSFSLSVRDFD   G+V+KHY
Sbjct: 103 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHY 162

Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVP 241
           KIR+LDNGG+YISPRITFP + ++++HY   +DGLC RL + C + KPQKPW +D WE+P
Sbjct: 163 KIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIP 222

Query: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLV 301
           RE++KLV+RLGAGQFGEVWMGYYN  TKVAVK+LK G+MS  AFL EANLMK LQH +LV
Sbjct: 223 RESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV 282

Query: 302 RLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY 360
           RLYAVVT +EPIYIITEYM  GSL+DFLK+  G K+ + KL+D +AQIAEGMA+IE +NY
Sbjct: 283 RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNY 342

Query: 361 IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK 420
           IHRDLRAAN+LVS++L CKIADFGLAR+IEDNEYTAREGAKFPIKWTAPEAIN+G FTIK
Sbjct: 343 IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 402

Query: 421 SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER 480
           SDVWSFGILL EIVT+G+IPYPG TN +V+  L +GYRM R +NCP+ELY +M++CWKE+
Sbjct: 403 SDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK 462

Query: 481 PEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
            E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 463 AEERPTFDYLQSVLDDFYTATEGQYQQQP 491


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  634 bits (1634), Expect = 0.0
 Identities = 305/470 (64%), Positives = 382/470 (81%), Gaps = 11/470 (2%)

Query: 47  PLVTYEGSNPPASPLQDNL------VIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA 100
           PLV +    PP  P  ++L      V+AL+ Y   +D DL   KGE+L++L+ +G+WW A
Sbjct: 40  PLVVFNHLTPP--PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLA 97

Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
           +SL TG+EG++P NFVA+  SLE E WFF++  RK+AERQLLAP N  GSFLIRESE+  
Sbjct: 98  RSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNK 157

Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
           G+FSLSV+D    QGE++KHYKIR LD GG+YISPRITFP L  LV+HY+   DGLC RL
Sbjct: 158 GAFSLSVKDVT-TQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRL 216

Query: 221 SRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
           + PC    PQ PW +DEWE+PR++L+LV +LG+GQFGEVWMGYY  + KVA+K+LK+G+M
Sbjct: 217 TLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTM 276

Query: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
           SP+AFL EAN+MK LQH+RLVRLYAVVT+EPIYI+TEYM  G L+DFLKT  G +L++ +
Sbjct: 277 SPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336

Query: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
           L+DM+AQIAEGMA+IE  N IHRDLRAANILVS+ L CKIADFGLAR+I D+EYTA+EGA
Sbjct: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGA 395

Query: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
           KFPIKWTAPEAI++G FTIK+DVWSFG+LL E+VT+GR+PYPGM+NPEVI+NLERGYRM 
Sbjct: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455

Query: 461 RPDNCPEELYQ-LMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509
           RPD CP ELY+ ++  CW+ RPE+RPTF++L+SVLEDF+TATE QY+ QP
Sbjct: 456 RPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  586 bits (1510), Expect = e-167
 Identities = 282/448 (62%), Positives = 355/448 (79%), Gaps = 5/448 (1%)

Query: 65  LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
           L +AL+ YE   + DL F KGE+ +IL  S G+WW+A+SLTTG+ G+IP N+VA  +S++
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145

Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
            E W+F  L RKDAERQLL+ GN  G+FLIRESE+T G++SLS+RD+D  +G+ VKHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205

Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ----KPWWEDEWE 239
           R LDNGG+YI+ R  F  L +LV+HY+  + GLC RL  PC    P+        +D WE
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265

Query: 240 VPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQR 299
           +PRE+L+L++RLG GQFGEVWMG +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +
Sbjct: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325

Query: 300 LVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
           LV+LYAVV++EPIYI+TEYM  GSL+DFLK   G  L +  L+DMAAQ+A GMA+IE  N
Sbjct: 326 LVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 385

Query: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
           YIHRDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  YG FTI
Sbjct: 386 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 445

Query: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
           KSDVWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM  P +CP  L++LM  CWK+
Sbjct: 446 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 505

Query: 480 RPEDRPTFDYLRSVLEDFFTATEGQYQP 507
            PE+RPTF+YL+S LED+FTATE QYQP
Sbjct: 506 DPEERPTFEYLQSFLEDYFTATEPQYQP 533


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  583 bits (1503), Expect = e-166
 Identities = 277/445 (62%), Positives = 353/445 (79%), Gaps = 2/445 (0%)

Query: 65  LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
           + +AL+ YE     DL F+KGE+ +I+  + G+WW+A+S+ TG+ G+IP N+VA A+S++
Sbjct: 95  IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154

Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
            E W+F  + RKDAER LL PGN  G FL+RESE+T G++SLS+RD+D+ +G+ VKHYKI
Sbjct: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214

Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
           R LDNGG+YI+ R  F  L +LV+HYT  +DGLC +L+  C T KPQ     +D WE+PR
Sbjct: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274

Query: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
           E+L+L  +LG G FGEVWMG +NG TKVA+K+LK G+M P+AFL EA +MK+L+H +LV 
Sbjct: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334

Query: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
           LYAVV++EPIYI+TE+M  GSL+DFLK   G  L + +L+DMAAQIA+GMA+IE  NYIH
Sbjct: 335 LYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIH 394

Query: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
           RDLRAANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  YG FTIKSD
Sbjct: 395 RDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 454

Query: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
           VWSFGIL TE+VT GR+PYPGM N EV++ +ERGYRM  P  CPE L++LM LCWK+ P+
Sbjct: 455 VWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 514

Query: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
           +RPTF+Y++S LED+FTATE QYQP
Sbjct: 515 ERPTFEYIQSFLEDYFTATEPQYQP 539


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  569 bits (1466), Expect = e-162
 Identities = 276/445 (62%), Positives = 349/445 (78%), Gaps = 2/445 (0%)

Query: 65  LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
           L +AL+ YE   + DL F KGE+ +IL  S G+WW+A+SLTTG+ G+IP N+VA  +S++
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145

Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
            E W+F  L RKDAERQLL+ GN  G+FLIRESE+T G++SLS+RD+D  +G+ VKHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205

Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
           R LDNGG+YI+ R  F  L +LV+HY+  +DGLC  L+    +  PQ     +D WEV R
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265

Query: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
            +L L ++LG G F EVW+G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+
Sbjct: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325

Query: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
           LYAVV++EPIYI+TEYM  GSL+DFLK   G  L +  L+DMAAQ+A GMA+IE  NYIH
Sbjct: 326 LYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 385

Query: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
           RDLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  YG FTIKSD
Sbjct: 386 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 445

Query: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
           VWSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM  P +CP  L++LM  CWK+ PE
Sbjct: 446 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 505

Query: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
           +RPTF+YL+S LED+FTATE QYQP
Sbjct: 506 ERPTFEYLQSFLEDYFTATEPQYQP 530


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  566 bits (1459), Expect = e-161
 Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)

Query: 58  ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114
           A PL   +   +AL+ YE   + DL F+KGE+L+I+  + G+WW A SL+TGQ G+IP N
Sbjct: 79  AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138

Query: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174
           +VA ++S++ E W+F  ++R+++ER LL   N  G+FL+RESE+T G++ LSV DFD  +
Sbjct: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198

Query: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234
           G  VKHYKIR LD+GGFYI+ R  F  L +LV +Y+  +DGLC RL+  C T KPQ    
Sbjct: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258

Query: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293
            +D WE+PRE+L+L  +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318

Query: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
           +L+H++LV+LYAVV++EPIYI+TEYM  GSL+DFLK  +G  L + +L+DMAAQIA GMA
Sbjct: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378

Query: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
           ++E  NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  
Sbjct: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438

Query: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
           YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+  +ERGYRM  P  CPE L+ LM
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498

Query: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
             CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  566 bits (1459), Expect = e-161
 Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)

Query: 58  ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114
           A PL   +   +AL+ YE   + DL F+KGE+L+I+  + G+WW A SL+TGQ G+IP N
Sbjct: 79  AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138

Query: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174
           +VA ++S++ E W+F  ++R+++ER LL   N  G+FL+RESE+T G++ LSV DFD  +
Sbjct: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198

Query: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234
           G  VKHYKIR LD+GGFYI+ R  F  L +LV +Y+  +DGLC RL+  C T KPQ    
Sbjct: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258

Query: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293
            +D WE+PRE+L+L  +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318

Query: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
           +L+H++LV+LYAVV++EPIYI+TEYM  GSL+DFLK  +G  L + +L+DMAAQIA GMA
Sbjct: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378

Query: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
           ++E  NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  
Sbjct: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438

Query: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
           YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+  +ERGYRM  P  CPE L+ LM
Sbjct: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498

Query: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
             CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  553 bits (1426), Expect = e-157
 Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)

Query: 42  SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100
           S+  +P     G+    S +   L IAL+ YE   + DL F KGE+  IL  + G+WW+A
Sbjct: 58  SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117

Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
           +SL++G+ G IP N+VA  +S++ E W+F  + RKDAERQLL+PGN  G+FLIRESE+T 
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177

Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
           G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F  + ELV+HY   +DGLC  L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237

Query: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279
             PC   KPQ     +D WE+ R ++ L  RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297

Query: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339
           MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G  L + 
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357

Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
           +L+DMAAQ+AEGMA++E  NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY   +G
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417

Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
           +KFPIKWTAPEA  +G FTIKSDVWSFGILLTE++T GRIPYPGM   EV++ +E+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477

Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
             P  CP  LY+ M   W+  PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  553 bits (1426), Expect = e-157
 Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)

Query: 42  SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100
           S+  +P     G+    S +   L IAL+ YE   + DL F KGE+  IL  + G+WW+A
Sbjct: 58  SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117

Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
           +SL++G+ G IP N+VA  +S++ E W+F  + RKDAERQLL+PGN  G+FLIRESE+T 
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177

Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
           G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F  + ELV+HY   +DGLC  L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237

Query: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279
             PC   KPQ     +D WE+ R ++ L  RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297

Query: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339
           MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G  L + 
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357

Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
           +L+DMAAQ+AEGMA++E  NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY   +G
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417

Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
           +KFPIKWTAPEA  +G FTIKSDVWSFGILLTE++T GRIPYPGM   EV++ +E+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477

Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
             P  CP  LY+ M   W+  PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  553 bits (1426), Expect = e-157
 Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)

Query: 42  SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100
           S+  +P     G+    S +   L IAL+ YE   + DL F KGE+  IL  + G+WW+A
Sbjct: 58  SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117

Query: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160
           +SL++G+ G IP N+VA  +S++ E W+F  + RKDAERQLL+PGN  G+FLIRESE+T 
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177

Query: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220
           G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F  + ELV+HY   +DGLC  L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237

Query: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279
             PC   KPQ     +D WE+ R ++ L  RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297

Query: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339
           MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G  L + 
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357

Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
           +L+DMAAQ+AEGMA++E  NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY   +G
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417

Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
           +KFPIKWTAPEA  +G FTIKSDVWSFGILLTE++T GRIPYPGM   EV++ +E+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477

Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
             P  CP  LY+ M   W+  PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  510 bits (1314), Expect = e-144
 Identities = 255/444 (57%), Positives = 320/444 (72%), Gaps = 52/444 (11%)

Query: 65  LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
           L +AL+ YE   + DL F KGE+ +IL  S G+WW+A+SLTTG+ G+IP N+VA  +S++
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145

Query: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
            E W+F  L RKDAERQLL+ GN  G+FLIRESE+T G++SLS+RD+D  +G+ VKHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205

Query: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243
           R LDNGG+YI+ R  F  L +LV+HY+                                 
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232

Query: 244 TLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRL 303
                             G +NG+TKVA+K+LK G+MSP++FL EA +MK+L+H +LV+L
Sbjct: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274

Query: 304 YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 363
           YAVV++EPIYI+TEYM  GSL+DFLK   G  L +  L+DMAAQ+A GMA+IE  NYIHR
Sbjct: 275 YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 334

Query: 364 DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV 423
           DLR+ANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA  YG FTIKSDV
Sbjct: 335 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 394

Query: 424 WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPED 483
           WSFGILLTE+VT GR+PYPGM N EV++ +ERGYRM  P +CP  L++LM  CWK+ PE+
Sbjct: 395 WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE 454

Query: 484 RPTFDYLRSVLEDFFTATEGQYQP 507
           RPTF+YL+S LED+FTATE QYQP
Sbjct: 455 RPTFEYLQSFLEDYFTATEPQYQP 478


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  449 bits (1155), Expect = e-126
 Identities = 233/466 (50%), Positives = 314/466 (67%), Gaps = 23/466 (4%)

Query: 57  PASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGE-WWKAQSLTTGQEG------ 109
           P S    +  +AL  Y+     DL F  G++L++L+   E WW A+ L   ++G      
Sbjct: 38  PQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQ 97

Query: 110 -FIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVR 168
            +IP N+VA+  SL+ EPWFF  + R DAE+QLL   N  GSFLIRESES  G FSLSV 
Sbjct: 98  GYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL 157

Query: 169 DFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQK 228
           D     G VVKHY+I+ LD GGF+++ R  F  L+E V HYT  SDGLC +L +PC   +
Sbjct: 158 D-----GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQ 212

Query: 229 PQKPW-----WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD 283
              P+       D+WE+ R +++L++RLG+GQFGEVW G +N  T VAVK+LK GSM P+
Sbjct: 213 VPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN 272

Query: 284 AFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLL 342
            FL EA +MK L+H +L++LYAV T ++PIYIITE M +GSL ++L+  +G K+ + + +
Sbjct: 273 DFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV 332

Query: 343 DMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNE--YTAREG 399
           DMAAQ+A GMA++E RNYIHRDL A N+LV +    K+ADFGLAR+ + DNE  Y +R  
Sbjct: 333 DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE 392

Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
            K P+KWTAPEAI    F+IKSDVWSFGILL EI+T+G++PY GMT  +VIQ L + YR+
Sbjct: 393 IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRL 452

Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQY 505
            +P NCP++ Y +M  CW   P++RPTF+ LR  LED+F  T+  Y
Sbjct: 453 PQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  367 bits (941), Expect = e-101
 Identities = 201/454 (44%), Positives = 278/454 (61%), Gaps = 17/454 (3%)

Query: 46  DPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTT 105
           DP+ T      P SP    L +AL+ +     G+L   +G++L  LE+ G +  A+ L+ 
Sbjct: 39  DPVPTLPAE--PCSPFPQ-LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLS- 94

Query: 106 GQE--GFIPFNFVAKAN--SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAG 161
           GQ   G +P   VAKA+  +L  +PW+F  +SR  A++ LL+P N  G+FLIR SES+ G
Sbjct: 95  GQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLG 154

Query: 162 SFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLS 221
            +SLSVR     Q +V  HY++    +G  Y+     FPGL EL+ +Y      +   L 
Sbjct: 155 GYSLSVRA----QAKVC-HYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLL 209

Query: 222 RPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMS 281
           +PC  QK  +   +D WE P     L  +LG G FGEVW G + G   VA+K +K  +M 
Sbjct: 210 QPCMPQKAPR---QDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMK 266

Query: 282 PDAFLAEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINK 340
                 E   +K L+H+RL+RL+AV +  EP+YI+TE M  G+L  FL TP G  L +  
Sbjct: 267 LTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPP 326

Query: 341 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 400
           LL  A Q+AEGM+++EE+  +HRDL A N+LV D L+CK+ADFGLARL++D+ Y+    +
Sbjct: 327 LLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSS 386

Query: 401 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV 460
           K P+KWTAPEA NY  F+ KSDVWSFG+LL E+ T+G+ PY GMTN E +Q + RGYR+ 
Sbjct: 387 KIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLP 446

Query: 461 RPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVL 494
           RP  CP E+Y LM  CW+  PE+RP+F  LR  L
Sbjct: 447 RPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  359 bits (921), Expect = 4e-99
 Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 17/443 (3%)

Query: 64  NLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
           NL +AL+ +  S D  L   KGE+LR+L    +GEW +AQ  T   +G++P N++   NS
Sbjct: 64  NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNS 121

Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
           LE   W+   +SR  AE  LL+ G  +GSFL+RESES+ G  S+S+R     +G V  HY
Sbjct: 122 LEKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HY 174

Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE----DE 237
           +I    +G  Y+S    F  L ELV H++  +DGL T L  P   +     +      D+
Sbjct: 175 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 234

Query: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAEANLMKQLQ 296
           WE+ R  + +  +LG GQ+GEV+ G +  ++  VAVK+LK+ +M  + FL EA +MK+++
Sbjct: 235 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 294

Query: 297 HQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 355
           H  LV+L  V T+EP  YIITE+M  G+L+D+L+  +  ++    LL MA QI+  M ++
Sbjct: 295 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 354

Query: 356 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG 415
           E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWTAPE++ Y 
Sbjct: 355 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 414

Query: 416 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL 475
            F+IKSDVW+FG+LL EI T+G  PYPG+   +V + LE+ YRM RP+ CPE++Y+LMR 
Sbjct: 415 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 474

Query: 476 CWKERPEDRPTFDYLRSVLEDFF 498
           CW+  P DRP+F  +    E  F
Sbjct: 475 CWQWNPSDRPSFAEIHQAFETMF 497


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  359 bits (921), Expect = 4e-99
 Identities = 195/443 (44%), Positives = 280/443 (63%), Gaps = 17/443 (3%)

Query: 64  NLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANS 121
           NL +AL+ +  S D  L   KGE+LR+L    +GEW +AQ  T   +G++P N++   NS
Sbjct: 83  NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNS 140

Query: 122 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 181
           LE   W+   +SR  AE  LL+ G  +GSFL+RESES+ G  S+S+R     +G V  HY
Sbjct: 141 LEKHSWYHGPVSRNAAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HY 193

Query: 182 KIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWE----DE 237
           +I    +G  Y+S    F  L ELV H++  +DGL T L  P   +     +      D+
Sbjct: 194 RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK 253

Query: 238 WEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAEANLMKQLQ 296
           WE+ R  + +  +LG GQ+GEV+ G +  ++  VAVK+LK+ +M  + FL EA +MK+++
Sbjct: 254 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 313

Query: 297 HQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFI 355
           H  LV+L  V T+EP  YIITE+M  G+L+D+L+  +  ++    LL MA QI+  M ++
Sbjct: 314 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 373

Query: 356 EERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG 415
           E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWTAPE++ Y 
Sbjct: 374 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN 433

Query: 416 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRL 475
            F+IKSDVW+FG+LL EI T+G  PYPG+   +V + LE+ YRM RP+ CPE++Y+LMR 
Sbjct: 434 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 493

Query: 476 CWKERPEDRPTFDYLRSVLEDFF 498
           CW+  P DRP+F  +    E  F
Sbjct: 494 CWQWNPSDRPSFAEIHQAFETMF 516


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  358 bits (920), Expect = 5e-99
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 89  ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 146

Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 200

Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 201 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 257

Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 258 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 317

Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 318 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 377

Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 437

Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 438 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 497

Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 498 KVYELMRACWKWSPADRPSFAETHQAFETMF 528


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  358 bits (920), Expect = 5e-99
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 104 ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 161

Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 215

Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 216 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 272

Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 273 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 332

Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 333 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 392

Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 393 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 452

Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 453 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 512

Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 513 KVYELMRACWKWSPADRPSFAETHQAFETMF 543


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  358 bits (920), Expect = 5e-99
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 83  ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 140

Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 141 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 194

Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 195 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 251

Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 252 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 311

Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 312 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 371

Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 372 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 431

Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 432 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 491

Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 492 KVYELMRACWKWSPADRPSFAETHQAFETMF 522


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  358 bits (920), Expect = 5e-99
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 89  ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 146

Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 200

Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 201 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 257

Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 258 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 317

Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 318 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 377

Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 437

Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 438 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 497

Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 498 KVYELMRACWKWSPADRPSFAETHQAFETMF 528


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  358 bits (920), Expect = 5e-99
 Identities = 198/451 (43%), Positives = 281/451 (62%), Gaps = 21/451 (4%)

Query: 58  ASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNF 115
           A+    NL +AL+ +  S D  L   KGE+LR+L   Q+GEW + +S     +G++P N+
Sbjct: 68  ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNY 125

Query: 116 VAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQG 175
           +   NSLE   W+   +SR  AE  L +  N  GSFL+RESES+ G  S+S+R     +G
Sbjct: 126 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR----YEG 179

Query: 176 EVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW- 234
            V  HY+I    +G  Y++    F  L ELV H++  +DGL T L  P    K  KP   
Sbjct: 180 RVY-HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAP--KCNKPTVY 236

Query: 235 -----EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT-KVAVKSLKQGSMSPDAFLAE 288
                 D+WE+ R  + +  +LG GQ+GEV++G +  ++  VAVK+LK+ +M  + FL E
Sbjct: 237 GVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKE 296

Query: 289 ANLMKQLQHQRLVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 347
           A +MK+++H  LV+L  V T EP  YI+TEYM  G+L+D+L+  +  ++T   LL MA Q
Sbjct: 297 AAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ 356

Query: 348 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 407
           I+  M ++E++N+IHRDL A N LV +    K+ADFGL+RL+  + YTA  GAKFPIKWT
Sbjct: 357 ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 416

Query: 408 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPE 467
           APE++ Y TF+IKSDVW+FG+LL EI T+G  PYPG+   +V   LE+GYRM +P+ CP 
Sbjct: 417 APESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPP 476

Query: 468 ELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
           ++Y+LMR CWK  P DRP+F       E  F
Sbjct: 477 KVYELMRACWKWSPADRPSFAETHQAFETMF 507


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score =  345 bits (885), Expect = 6e-95
 Identities = 181/438 (41%), Positives = 268/438 (61%), Gaps = 14/438 (3%)

Query: 67  IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTG----QEGFIPFNFVAKANSL 122
           + L  ++   D +L F  G+   +  +  +WW A  L        +G++P N++A+  ++
Sbjct: 14  VGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETV 73

Query: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
           E EPWFF  +SR +A R+L A GN  G+FLIR SE  +  + LSVRD      + V+HYK
Sbjct: 74  ESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT-----QAVRHYK 128

Query: 183 IRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQK-PWWEDEWEVP 241
           I     G  +++  ++F  L ELV ++   S     RL+ PC+  +P+  P W+D WE P
Sbjct: 129 IWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDD-WERP 187

Query: 242 RETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL-AEANLMKQLQHQRL 300
           RE   L  +LG+G FGEV+ G +    +VA+K + + ++     L +E   MK+L+H+ +
Sbjct: 188 REEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHI 247

Query: 301 VRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 359
           + LYAVV+  +P+YIITE M  GSL++ L+      L +++LLD+A Q+AEGM ++E +N
Sbjct: 248 LALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQN 307

Query: 360 YIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 419
           YIHRDL A NILV +   CK+ DFGLARLI+++ Y + +    P KWTAPEA++ G ++ 
Sbjct: 308 YIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHYST 366

Query: 420 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKE 479
           KSDVWSFGILL E+ + G++PYPGM+N E    ++ GYRM  P  CP  +++LM  CW  
Sbjct: 367 KSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCR 426

Query: 480 RPEDRPTFDYLRSVLEDF 497
            PE RP F  LR  L  F
Sbjct: 427 DPEQRPCFKALRERLSSF 444


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  329 bits (843), Expect = 4e-90
 Identities = 176/455 (38%), Positives = 277/455 (60%), Gaps = 16/455 (3%)

Query: 52  EGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGF 110
           E +  P S  +   V+AL+ Y P +  DL   KG++  ILE+S   WW+A+    GQEG+
Sbjct: 205 EPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGY 263

Query: 111 IPFNFVAKA-NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRD 169
           IP N+V +A +S+E   W+ K+++R  AE QLL      G F++R+S S AG +++SV  
Sbjct: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDS-SKAGKYTVSV-- 319

Query: 170 FDQNQGE---VVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQT 226
           F ++ G+   V++HY + +     +Y++ +  F  + EL+ ++ + S GL +RL  P   
Sbjct: 320 FAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQ 379

Query: 227 QKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP 282
           Q    P         WE+  + L  ++ LG GQFG V  G + G   VA+K +K+GSMS 
Sbjct: 380 QNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE 439

Query: 283 DAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKL 341
           D F+ EA +M  L H++LV+LY V T Q PI+IITEYM NG L+++L+     +    +L
Sbjct: 440 DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQL 498

Query: 342 LDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAK 401
           L+M   + E M ++E + ++HRDL A N LV+D    K++DFGL+R + D+EYT+  G+K
Sbjct: 499 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 558

Query: 402 FPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVR 461
           FP++W+ PE + Y  F+ KSD+W+FG+L+ EI + G++PY   TN E  +++ +G R+ R
Sbjct: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618

Query: 462 PDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 496
           P    E++Y +M  CW E+ ++RPTF  L S + D
Sbjct: 619 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILD 653


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  328 bits (840), Expect = 9e-90
 Identities = 175/451 (38%), Positives = 276/451 (61%), Gaps = 15/451 (3%)

Query: 56  PPASPLQDNLVI-ALHSYEPSHDGDLGFEKGEQLRILEQ-SGEWWKAQSLTTGQEGFIPF 113
           PP+   ++ + + AL+ + P    +L   + E+  ILE+ +  WWKA+    G EG IP 
Sbjct: 76  PPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPS 134

Query: 114 NFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFD 171
           N+V   K  +LE   W+ +N++R  AE  LL   +  G+F++R+S    GS+++SV    
Sbjct: 135 NYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGA 192

Query: 172 QNQGEV-VKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ 230
           +   E  +KHY+I+  D+G +Y++ R  F  + EL+ ++ + + GL TRL  P       
Sbjct: 193 RRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSC 252

Query: 231 KP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL 286
            P    +  ++WE+    L  ++ +G+GQFG V +G +  H +VA+K++ +GSMS + F+
Sbjct: 253 LPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFI 312

Query: 287 AEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMA 345
            EA +M +L H +LV+LY V  Q +P+YI+TE+MENG L+++L+   G KL    LL + 
Sbjct: 313 EEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVC 371

Query: 346 AQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIK 405
             I EGM ++E   YIHRDL A N LVS T   KI+DFG+ R + D+EY +  GAKFPIK
Sbjct: 372 QDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIK 431

Query: 406 WTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNC 465
           W+ PE   +  ++ KSDVWSFG+L+ E+ T G++P+   +N +V++ +  G+R+ RP   
Sbjct: 432 WSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLA 491

Query: 466 PEELYQLMRLCWKERPEDRPTF-DYLRSVLE 495
           P  +Y++M  CW E+PE RPTF + LR+V E
Sbjct: 492 PMSIYEVMYSCWHEKPEGRPTFAELLRAVTE 522


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  321 bits (822), Expect = 1e-87
 Identities = 169/463 (36%), Positives = 279/463 (60%), Gaps = 20/463 (4%)

Query: 56  PPASPLQDN-----LVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEG 109
           PP  PL++      +V+A++ ++ +   DL  E+G++  ILE++   WW+A+    G EG
Sbjct: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEG 227

Query: 110 FIPFNFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV 167
           +IP N+V   K+N+L+   W+ +N++R  AE QLL   +  G F++R+S S  G +++S+
Sbjct: 228 YIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSL 285

Query: 168 -RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSRPC 224
              F        +HY I+        +Y++ +  F  + E++ ++ + + GL TRL  P 
Sbjct: 286 YTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPV 345

Query: 225 QTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
             +    P    +  ++WE+    L  +  LG+G FG V +G +    KVA+K++++G+M
Sbjct: 346 SVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM 405

Query: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTIN 339
             + F+ EA +M +L H +LV+LY V TQ+ PIYI+TE+ME G L++FL+   G   + +
Sbjct: 406 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRD 464

Query: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
            LL M   + EGM ++E  ++IHRDL A N LVS+    K++DFG+AR + D++YT+  G
Sbjct: 465 VLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSG 524

Query: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
           AKFP+KW  PE  NY  F+ KSDVWSFG+L+ E+ T GR+P+   TN EV+  + RG+R+
Sbjct: 525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRL 584

Query: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATE 502
            +P      +Y++M  CW+E+PE RP+F+ L   +++     E
Sbjct: 585 YQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  316 bits (810), Expect = 3e-86
 Identities = 164/453 (36%), Positives = 271/453 (59%), Gaps = 16/453 (3%)

Query: 50  TYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQE 108
           T E +  P    ++ +VIAL+ Y+ +   +L   + E+  +L+ S   WW+ Q    G E
Sbjct: 160 TPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHE 218

Query: 109 GFIPFNFVAKA--NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLS 166
           G++P +++ +   N+LE   W+ K++SR  AE+ LL  G   G+F++R+S  TAG++++S
Sbjct: 219 GYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSR-TAGTYTVS 276

Query: 167 V--RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSR 222
           V  +         +KHY I+  ++    +Y++ +  F  +  L+ ++ +   GL TRL  
Sbjct: 277 VFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRY 336

Query: 223 PCQTQKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQG 278
           P    + + P        +W +    L  V+ +G+GQFG V +GY+    KVA+K++++G
Sbjct: 337 PVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREG 396

Query: 279 SMSPDAFLAEANLMKQLQHQRLVRLYAV-VTQEPIYIITEYMENGSLVDFLKTPSGIKLT 337
           +MS + F+ EA +M +L H +LV+LY V + Q PI ++ E+ME+G L D+L+T  G+   
Sbjct: 397 AMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FA 455

Query: 338 INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAR 397
              LL M   + EGMA++EE   IHRDL A N LV +    K++DFG+ R + D++YT+ 
Sbjct: 456 AETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSS 515

Query: 398 EGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGY 457
            G KFP+KW +PE  ++  ++ KSDVWSFG+L+ E+ + G+IPY   +N EV++++  G+
Sbjct: 516 TGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGF 575

Query: 458 RMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL 490
           R+ +P      +YQ+M  CWKERPEDRP F  L
Sbjct: 576 RLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  297 bits (761), Expect = 1e-80
 Identities = 177/446 (39%), Positives = 260/446 (58%), Gaps = 28/446 (6%)

Query: 67  IALHSYEPSHDGDLGFEKGEQLRILEQSGE--WWKAQSLTTGQEGFIPFNFVAK------ 118
           IA +++  + + DL F KG+ L I+  + +  W+KA++   G+EG IP N+V K      
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73

Query: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
              L   PWF   ++R+ AER L  P    G FL+RES +  G ++L V    +     V
Sbjct: 74  GTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGK-----V 126

Query: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWE 235
           +HY+I         I   + F  L +LV HYT+ +DGLCTRL +P     T   Q  ++ 
Sbjct: 127 EHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYR 185

Query: 236 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL 295
             W +  + LKL++ +G G+FG+V +G Y G+ KVAVK +K  + +  AFLAEA++M QL
Sbjct: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQL 243

Query: 296 QHQRLVRLYAVVTQEP--IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
           +H  LV+L  V+ +E   +YI+TEYM  GSLVD+L++     L  + LL  +  + E M 
Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303

Query: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
           ++E  N++HRDL A N+LVS+    K++DFGL +     + T     K P+KWTAPEA+ 
Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359

Query: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
              F+ KSDVWSFGILL EI + GR+PYP +   +V+  +E+GY+M  PD CP  +Y++M
Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419

Query: 474 RLCWKERPEDRPTFDYLRSVLEDFFT 499
           + CW      RP+F  LR  LE   T
Sbjct: 420 KNCWHLDAAMRPSFLQLREQLEHIKT 445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,116,685
Number of Sequences: 37866
Number of extensions: 994557
Number of successful extensions: 4364
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 701
Number of HSP's successfully gapped in prelim test: 267
Number of HSP's that attempted gapping in prelim test: 2097
Number of HSP's gapped (non-prelim): 1162
length of query: 509
length of database: 18,247,518
effective HSP length: 107
effective length of query: 402
effective length of database: 14,195,856
effective search space: 5706734112
effective search space used: 5706734112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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