Guide to the Human Genome
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Search of human proteins with 101943240

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|101943240 general transcription factor IIIC, polypeptide 1,
alpha 220kDa [Homo sapiens]
         (2109 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|101943240 general transcription factor IIIC, polypeptide 1, a...  4233   0.0  
gi|40556370 PHD finger protein 15 [Homo sapiens]                       45   6e-04
gi|55741849 WD repeat domain 22 [Homo sapiens]                         42   0.006
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)...    42   0.008
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)...    42   0.008
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)...    42   0.008
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    41   0.011
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       41   0.014
gi|6912458 calcineurin binding protein 1 [Homo sapiens]                41   0.014
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      40   0.018
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     40   0.018
gi|41349486 proline-rich protein BstNI subfamily 1 isoform 3 pre...    40   0.018
gi|7662162 ALEX2 protein [Homo sapiens]                                40   0.018
gi|29540562 ALEX2 protein [Homo sapiens]                               40   0.018
gi|119395716 forkhead box C1 [Homo sapiens]                            39   0.041
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    39   0.041
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    39   0.041
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    39   0.041
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    39   0.041
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    39   0.041
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    39   0.041
gi|146219832 myosin light chain kinase 3 [Homo sapiens]                39   0.041
gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]              39   0.054
gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ...    39   0.054
gi|38201627 eukaryotic translation initiation factor 4 gamma, 1 ...    39   0.054
gi|38201625 eukaryotic translation initiation factor 4 gamma, 1 ...    39   0.054
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ...    39   0.054
gi|38201619 eukaryotic translation initiation factor 4 gamma, 1 ...    39   0.054
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              39   0.054
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...    39   0.054

>gi|101943240 general transcription factor IIIC, polypeptide 1, alpha
            220kDa [Homo sapiens]
          Length = 2109

 Score = 4233 bits (10978), Expect = 0.0
 Identities = 2109/2109 (100%), Positives = 2109/2109 (100%)

Query: 1    MDALESLLDEVALEGLDGLCLPALWSRLETRVPPFPLPLEPCTQEFLWRALATHPGISFY 60
            MDALESLLDEVALEGLDGLCLPALWSRLETRVPPFPLPLEPCTQEFLWRALATHPGISFY
Sbjct: 1    MDALESLLDEVALEGLDGLCLPALWSRLETRVPPFPLPLEPCTQEFLWRALATHPGISFY 60

Query: 61   EEPRERPDLQLQDRYEEIDLETGILESRRDPVALEDVYPIHMILENKDGIQGSCRYFKER 120
            EEPRERPDLQLQDRYEEIDLETGILESRRDPVALEDVYPIHMILENKDGIQGSCRYFKER
Sbjct: 61   EEPRERPDLQLQDRYEEIDLETGILESRRDPVALEDVYPIHMILENKDGIQGSCRYFKER 120

Query: 121  KNITNDIRTKSLQPRCTMVEAFDRWGKKLIIVASQAMRYRALIGQEGDPDLKLPDFSYCI 180
            KNITNDIRTKSLQPRCTMVEAFDRWGKKLIIVASQAMRYRALIGQEGDPDLKLPDFSYCI
Sbjct: 121  KNITNDIRTKSLQPRCTMVEAFDRWGKKLIIVASQAMRYRALIGQEGDPDLKLPDFSYCI 180

Query: 181  LERLGRSRWQGELQRDLHTTAFKVDAGKLHYHRKILNKNGLITMQSHVIRLPTGAQQHSI 240
            LERLGRSRWQGELQRDLHTTAFKVDAGKLHYHRKILNKNGLITMQSHVIRLPTGAQQHSI
Sbjct: 181  LERLGRSRWQGELQRDLHTTAFKVDAGKLHYHRKILNKNGLITMQSHVIRLPTGAQQHSI 240

Query: 241  LLLLNRFHVDRRSKYDILMEKLSVMLSTRTNHIETLGKLREELGLCERTFKRLYQYMLNA 300
            LLLLNRFHVDRRSKYDILMEKLSVMLSTRTNHIETLGKLREELGLCERTFKRLYQYMLNA
Sbjct: 241  LLLLNRFHVDRRSKYDILMEKLSVMLSTRTNHIETLGKLREELGLCERTFKRLYQYMLNA 300

Query: 301  GLAKVVSLRLQEIHPECGPCKTKKGTDVMVRCLKLLKEFKRNDHDDDEDEEVISKTVPPV 360
            GLAKVVSLRLQEIHPECGPCKTKKGTDVMVRCLKLLKEFKRNDHDDDEDEEVISKTVPPV
Sbjct: 301  GLAKVVSLRLQEIHPECGPCKTKKGTDVMVRCLKLLKEFKRNDHDDDEDEEVISKTVPPV 360

Query: 361  DIVFERDMLTQTYDLIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGFMEDE 420
            DIVFERDMLTQTYDLIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGFMEDE
Sbjct: 361  DIVFERDMLTQTYDLIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGFMEDE 420

Query: 421  GRQRTTKYISCVFAEESDLSRQYQREKARSELLTTVSLASMQEESLLPEGEDTFLSESDS 480
            GRQRTTKYISCVFAEESDLSRQYQREKARSELLTTVSLASMQEESLLPEGEDTFLSESDS
Sbjct: 421  GRQRTTKYISCVFAEESDLSRQYQREKARSELLTTVSLASMQEESLLPEGEDTFLSESDS 480

Query: 481  EEERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAE 540
            EEERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAE
Sbjct: 481  EEERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAE 540

Query: 541  ERACQSLASRDSLLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRMENPKESSSSLKTGR 600
            ERACQSLASRDSLLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRMENPKESSSSLKTGR
Sbjct: 541  ERACQSLASRDSLLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRMENPKESSSSLKTGR 600

Query: 601  HSSGQDKPHETYRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIV 660
            HSSGQDKPHETYRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIV
Sbjct: 601  HSSGQDKPHETYRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIV 660

Query: 661  RLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSSTA 720
            RLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSSTA
Sbjct: 661  RLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSSTA 720

Query: 721  NRVKTSQPPVPQGEAEEDSQGKEGPSGSGDSQLSASSRSESGRMKKSDNKMGITPLRNYH 780
            NRVKTSQPPVPQGEAEEDSQGKEGPSGSGDSQLSASSRSESGRMKKSDNKMGITPLRNYH
Sbjct: 721  NRVKTSQPPVPQGEAEEDSQGKEGPSGSGDSQLSASSRSESGRMKKSDNKMGITPLRNYH 780

Query: 781  PIVVPGLGRSLGFLPKMPRLRVVHMFLWYLIYGHPASNTVEKPSFISERRTIKQESGRAG 840
            PIVVPGLGRSLGFLPKMPRLRVVHMFLWYLIYGHPASNTVEKPSFISERRTIKQESGRAG
Sbjct: 781  PIVVPGLGRSLGFLPKMPRLRVVHMFLWYLIYGHPASNTVEKPSFISERRTIKQESGRAG 840

Query: 841  VRPSSSGSAWEACSEAPSKGSQDGVTWEAEVELATETVYVDDASWMRYIPPIPVHRDFGF 900
            VRPSSSGSAWEACSEAPSKGSQDGVTWEAEVELATETVYVDDASWMRYIPPIPVHRDFGF
Sbjct: 841  VRPSSSGSAWEACSEAPSKGSQDGVTWEAEVELATETVYVDDASWMRYIPPIPVHRDFGF 900

Query: 901  GWALVSDILLCLPLSIFIQIVQVSYKVDNLEEFLNDPLKKHTLIRFLPRPIRQQLLYKRR 960
            GWALVSDILLCLPLSIFIQIVQVSYKVDNLEEFLNDPLKKHTLIRFLPRPIRQQLLYKRR
Sbjct: 901  GWALVSDILLCLPLSIFIQIVQVSYKVDNLEEFLNDPLKKHTLIRFLPRPIRQQLLYKRR 960

Query: 961  YIFSVVENLQRLCYMGLLQFGPTEKFQDKDQVFIFLKKNAVIVDTTICDPHYNLARSSRP 1020
            YIFSVVENLQRLCYMGLLQFGPTEKFQDKDQVFIFLKKNAVIVDTTICDPHYNLARSSRP
Sbjct: 961  YIFSVVENLQRLCYMGLLQFGPTEKFQDKDQVFIFLKKNAVIVDTTICDPHYNLARSSRP 1020

Query: 1021 FERRLYVLNSMQDVENYWFDLQCVCLNTPLGVVRCPRVRKNSSTDQGSDEEGSLQKEQES 1080
            FERRLYVLNSMQDVENYWFDLQCVCLNTPLGVVRCPRVRKNSSTDQGSDEEGSLQKEQES
Sbjct: 1021 FERRLYVLNSMQDVENYWFDLQCVCLNTPLGVVRCPRVRKNSSTDQGSDEEGSLQKEQES 1080

Query: 1081 AMDKHNLERKCAMLEYTTGSREVVDEGLIPGDGLGAAGLDSSFYGHLKRNWIWTSYIINQ 1140
            AMDKHNLERKCAMLEYTTGSREVVDEGLIPGDGLGAAGLDSSFYGHLKRNWIWTSYIINQ
Sbjct: 1081 AMDKHNLERKCAMLEYTTGSREVVDEGLIPGDGLGAAGLDSSFYGHLKRNWIWTSYIINQ 1140

Query: 1141 AKKENTAAENGLTVRLQTFLSKRPMPLSARGNSRLNIWGEARVGSELCAGWEEQFEVDRE 1200
            AKKENTAAENGLTVRLQTFLSKRPMPLSARGNSRLNIWGEARVGSELCAGWEEQFEVDRE
Sbjct: 1141 AKKENTAAENGLTVRLQTFLSKRPMPLSARGNSRLNIWGEARVGSELCAGWEEQFEVDRE 1200

Query: 1201 PSLDRNRRVRGGKSQKRKRLKKDPGKKIKRKKKGEFPGEKSKRLRYHDEADQSALQRMTR 1260
            PSLDRNRRVRGGKSQKRKRLKKDPGKKIKRKKKGEFPGEKSKRLRYHDEADQSALQRMTR
Sbjct: 1201 PSLDRNRRVRGGKSQKRKRLKKDPGKKIKRKKKGEFPGEKSKRLRYHDEADQSALQRMTR 1260

Query: 1261 LRVTWSMQEDGLLVLCRIASNVLNTKVKGPFVTWQVVRDILHATFEESLDKTSHSVGRRA 1320
            LRVTWSMQEDGLLVLCRIASNVLNTKVKGPFVTWQVVRDILHATFEESLDKTSHSVGRRA
Sbjct: 1261 LRVTWSMQEDGLLVLCRIASNVLNTKVKGPFVTWQVVRDILHATFEESLDKTSHSVGRRA 1320

Query: 1321 RYIVKNPQAYLNYKVCLAEVYQDKALVGDFMNRRGDYDDPKVCANEFKEFVEKLKEKFSS 1380
            RYIVKNPQAYLNYKVCLAEVYQDKALVGDFMNRRGDYDDPKVCANEFKEFVEKLKEKFSS
Sbjct: 1321 RYIVKNPQAYLNYKVCLAEVYQDKALVGDFMNRRGDYDDPKVCANEFKEFVEKLKEKFSS 1380

Query: 1381 ALRNSNLEIPDTLQELFARYRVLAIGDEKDQTRKEDELNSVDDIHFLVLQNLIQSTLALS 1440
            ALRNSNLEIPDTLQELFARYRVLAIGDEKDQTRKEDELNSVDDIHFLVLQNLIQSTLALS
Sbjct: 1381 ALRNSNLEIPDTLQELFARYRVLAIGDEKDQTRKEDELNSVDDIHFLVLQNLIQSTLALS 1440

Query: 1441 DSQMKSYQSFQTFRLYREYKDHVLVKAFMECQKRSLVNRRRVNHTLGPKKNRALPFVPMS 1500
            DSQMKSYQSFQTFRLYREYKDHVLVKAFMECQKRSLVNRRRVNHTLGPKKNRALPFVPMS
Sbjct: 1441 DSQMKSYQSFQTFRLYREYKDHVLVKAFMECQKRSLVNRRRVNHTLGPKKNRALPFVPMS 1500

Query: 1501 YQLSQTYYRIFTWRFPSTICTESFQFLDRMRAAGKLDQPDRFSFKDQDNNEPTNDMVAFS 1560
            YQLSQTYYRIFTWRFPSTICTESFQFLDRMRAAGKLDQPDRFSFKDQDNNEPTNDMVAFS
Sbjct: 1501 YQLSQTYYRIFTWRFPSTICTESFQFLDRMRAAGKLDQPDRFSFKDQDNNEPTNDMVAFS 1560

Query: 1561 LDGPGGNCVAVLTLFSLGLISVDVRIPEQIIVVDSSMVENEVIKSLGKDGSLEDDEDEED 1620
            LDGPGGNCVAVLTLFSLGLISVDVRIPEQIIVVDSSMVENEVIKSLGKDGSLEDDEDEED
Sbjct: 1561 LDGPGGNCVAVLTLFSLGLISVDVRIPEQIIVVDSSMVENEVIKSLGKDGSLEDDEDEED 1620

Query: 1621 DLDEGVGGKRRSMEVKPAQASHTNYLLMRGYYSPGIVSTRNLNPNDSIVVNSCQMKFQLR 1680
            DLDEGVGGKRRSMEVKPAQASHTNYLLMRGYYSPGIVSTRNLNPNDSIVVNSCQMKFQLR
Sbjct: 1621 DLDEGVGGKRRSMEVKPAQASHTNYLLMRGYYSPGIVSTRNLNPNDSIVVNSCQMKFQLR 1680

Query: 1681 CTPVPARLRPAAAPLEELTMGTSCLPDTFTKLINPQENTCSLEEFVLQLELSGYSPEDLT 1740
            CTPVPARLRPAAAPLEELTMGTSCLPDTFTKLINPQENTCSLEEFVLQLELSGYSPEDLT
Sbjct: 1681 CTPVPARLRPAAAPLEELTMGTSCLPDTFTKLINPQENTCSLEEFVLQLELSGYSPEDLT 1740

Query: 1741 AALEILEAIIATGCFGIDKEELRRRFSALEKAGGGRTRTFADCIQALLEQHQVLEVGGNT 1800
            AALEILEAIIATGCFGIDKEELRRRFSALEKAGGGRTRTFADCIQALLEQHQVLEVGGNT
Sbjct: 1741 AALEILEAIIATGCFGIDKEELRRRFSALEKAGGGRTRTFADCIQALLEQHQVLEVGGNT 1800

Query: 1801 ARLVAMGSAWPWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGT 1860
            ARLVAMGSAWPWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGT
Sbjct: 1801 ARLVAMGSAWPWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGT 1860

Query: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920
            KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA
Sbjct: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920

Query: 1921 AAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAARERDCESV 1980
            AAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAARERDCESV
Sbjct: 1921 AAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAARERDCESV 1980

Query: 1981 CFIGRPWRVVDGHLNLPVCKGMMEAMLYHIMTRPGIPESSLLRHYQGVLQPVAVLELLQG 2040
            CFIGRPWRVVDGHLNLPVCKGMMEAMLYHIMTRPGIPESSLLRHYQGVLQPVAVLELLQG
Sbjct: 1981 CFIGRPWRVVDGHLNLPVCKGMMEAMLYHIMTRPGIPESSLLRHYQGVLQPVAVLELLQG 2040

Query: 2041 LESLGCIRKRWLRKPRPVSLFSTPVVEEVEVPSSLDESPMAFYEPTLDCTLRLGRVFPHE 2100
            LESLGCIRKRWLRKPRPVSLFSTPVVEEVEVPSSLDESPMAFYEPTLDCTLRLGRVFPHE
Sbjct: 2041 LESLGCIRKRWLRKPRPVSLFSTPVVEEVEVPSSLDESPMAFYEPTLDCTLRLGRVFPHE 2100

Query: 2101 VNWNKWIHL 2109
            VNWNKWIHL
Sbjct: 2101 VNWNKWIHL 2109


>gi|40556370 PHD finger protein 15 [Homo sapiens]
          Length = 790

 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 43/162 (26%), Positives = 62/162 (38%), Gaps = 20/162 (12%)

Query: 1811 PWLLHSVRLKDREDADIQREDPQARP------------LEGSSSEDSPPEGQAPPSHSPR 1858
            P LL    L+D E       DP  RP            L        PP    P S +  
Sbjct: 562  PGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPPQDGPGSRTTP 621

Query: 1859 GTKRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALED 1918
                + +W  + G    +G Q  P ++P  + S+  PS     +    A   SPPP   +
Sbjct: 622  DKAPKKTWGQDAGS--GKGGQGPPTRKPPRRTSSHLPSSPAAGDCPILATPESPPPLAPE 679

Query: 1919 T---AAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPR 1957
            T   AA+ AA  D +  G  +SP   +  G+ +PP  S+  R
Sbjct: 680  TPDEAASVAADSDVQVPGPAASP---KPLGRLRPPRESKVTR 718


>gi|55741849 WD repeat domain 22 [Homo sapiens]
          Length = 942

 Score = 42.0 bits (97), Expect = 0.006
 Identities = 50/183 (27%), Positives = 75/183 (40%), Gaps = 26/183 (14%)

Query: 1809 AWPWLLHSV----RLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRA 1864
            A+ WL +S       KD E + +  E  + R   G+S +D+P      PS S       A
Sbjct: 663  AYKWLRYSYISYSNNKDGETSLVTGEADEGRA--GTSHKDNPA-----PSSSKEACLNIA 715

Query: 1865 SWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGA 1924
              A  N +   EG      K    +++   PS GPG E  + A A  P    +DT  +G+
Sbjct: 716  M-AQRNQDLPPEGCSKDTFK----EETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGS 770

Query: 1925 AQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPR--GFTESFGAANI----SQAARERDCE 1978
                 E   E      + LS +A+ P     P+  G T + G+ N     S  + ER  E
Sbjct: 771  V----EHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLE 826

Query: 1979 SVC 1981
            ++C
Sbjct: 827  TIC 829


>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 41.6 bits (96), Expect = 0.008
 Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 12/165 (7%)

Query: 1818 RLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEG 1877
            ++++ E+    +ED    PL     E+   + +A  +         +S        D+  
Sbjct: 1203 KIQESEETVEPKED---MPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSN 1259

Query: 1878 TQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAP--SPPPALEDTAAAGAAQE-----DQE 1930
            +  T  K P +++    P +        E Q     P P  E+ AAA  AQ      D E
Sbjct: 1260 SPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDE 1319

Query: 1931 GVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAARER 1975
              G   S  +++L  Q    +  E+P G  ESF  AN+ Q +RE+
Sbjct: 1320 DDGHLESTKKKELEEQPTREDVKEEP-GVQESFLDANM-QKSREK 1362


>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 41.6 bits (96), Expect = 0.008
 Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 12/165 (7%)

Query: 1818 RLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEG 1877
            ++++ E+    +ED    PL     E+   + +A  +         +S        D+  
Sbjct: 1203 KIQESEETVEPKED---MPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSN 1259

Query: 1878 TQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAP--SPPPALEDTAAAGAAQE-----DQE 1930
            +  T  K P +++    P +        E Q     P P  E+ AAA  AQ      D E
Sbjct: 1260 SPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDE 1319

Query: 1931 GVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAARER 1975
              G   S  +++L  Q    +  E+P G  ESF  AN+ Q +RE+
Sbjct: 1320 DDGHLESTKKKELEEQPTREDVKEEP-GVQESFLDANM-QKSREK 1362


>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 41.6 bits (96), Expect = 0.008
 Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 12/165 (7%)

Query: 1818 RLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEG 1877
            ++++ E+    +ED    PL     E+   + +A  +         +S        D+  
Sbjct: 1203 KIQESEETVEPKED---MPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSN 1259

Query: 1878 TQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAP--SPPPALEDTAAAGAAQE-----DQE 1930
            +  T  K P +++    P +        E Q     P P  E+ AAA  AQ      D E
Sbjct: 1260 SPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDE 1319

Query: 1931 GVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAARER 1975
              G   S  +++L  Q    +  E+P G  ESF  AN+ Q +RE+
Sbjct: 1320 DDGHLESTKKKELEEQPTREDVKEEP-GVQESFLDANM-QKSREK 1362


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 41.2 bits (95), Expect = 0.011
 Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 13/131 (9%)

Query: 1832 PQARPLEGSS--SEDSPPEGQAPPS-----HSPRGTKRRASWASENGET-DAEGTQMTPA 1883
            PQ  PL   S   ++SPP   +PP+      SP     +    S+  E  + E  +++  
Sbjct: 1022 PQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEP 1081

Query: 1884 KRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQL 1943
            + PAL+ S  +P   P  +      APSP PAL+D +  G   ED   +    +PG +  
Sbjct: 1082 ECPALEPSATSPLPSPMGD--LSCPAPSPAPALDDFSGLG---EDTAPLDGIDAPGSQPE 1136

Query: 1944 SGQAQPPEGSE 1954
             GQ      SE
Sbjct: 1137 PGQTPGSLASE 1147


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 40.8 bits (94), Expect = 0.014
 Identities = 36/134 (26%), Positives = 53/134 (39%), Gaps = 7/134 (5%)

Query: 1823 EDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTP 1882
            E+A  + + P A+   G S E++P E Q PPS      +  ++       T+A   +   
Sbjct: 553  EEAPAEVQSPSAK---GVSIEEAPLELQ-PPSGEETTAEEASAAIQLLAATEASAEEAPA 608

Query: 1883 AKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQ 1942
              +P   +   A    P AE   EA A   PP  E+  A       +E   E   P  E+
Sbjct: 609  EVQPPPAEEAPAEVQPPPAE---EAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEE 665

Query: 1943 LSGQAQPPEGSEDP 1956
               + QPP   E P
Sbjct: 666  APAEVQPPPAEEAP 679



 Score = 38.9 bits (89), Expect = 0.054
 Identities = 37/137 (27%), Positives = 56/137 (40%), Gaps = 9/137 (6%)

Query: 1825 ADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGE-TDAE----GTQ 1879
            AD    + Q+   E +S+E++P E Q+P +      +        +GE T AE      Q
Sbjct: 535  ADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQ 594

Query: 1880 MTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPG 1939
            +  A   + +++       P  E  AE Q   PPPA E+  A       +E   E   P 
Sbjct: 595  LLAATEASAEEAPAEVQPPPAEEAPAEVQ---PPPA-EEAPAEVQPPPAEEAPAEVQPPP 650

Query: 1940 QEQLSGQAQPPEGSEDP 1956
             E+   + QPP   E P
Sbjct: 651  AEEAPAEVQPPPAEEAP 667


>gi|6912458 calcineurin binding protein 1 [Homo sapiens]
          Length = 2220

 Score = 40.8 bits (94), Expect = 0.014
 Identities = 41/138 (29%), Positives = 49/138 (35%), Gaps = 25/138 (18%)

Query: 1836 PLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETD--AEGTQMTPAKRPALQDSNL 1893
            P   +S+ D   +   P  H P  T   AS   E  E    AEGT   P +        +
Sbjct: 1981 PSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGEELARVAEGTSFPPQEPRHSPQVKM 2040

Query: 1894 APS--------------LGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSP- 1938
            AP+              LG GAE     +    P    D  A  AA E Q      SSP 
Sbjct: 2041 APTSSPAEPHCWPAEAALGTGAEPTCSQEGKLRPEPRRDGEAQEAASETQP----LSSPP 2096

Query: 1939 ----GQEQLSGQAQPPEG 1952
                 +   SG AQPPEG
Sbjct: 2097 TAASSKAPSSGSAQPPEG 2114


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 40.4 bits (93), Expect = 0.018
 Identities = 47/155 (30%), Positives = 55/155 (35%), Gaps = 21/155 (13%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            P A+ L GS     P     PP   P G   R       G     G    P  + A  + 
Sbjct: 535  PGAKGLTGSPGSPGPDGKTGPPG--PAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEP 592

Query: 1892 NLAP---------SLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQ 1942
              A          ++GP  +DG EA A  PP        AG A E  E  G   SPG + 
Sbjct: 593  GKAGERGVPGPPGAVGPAGKDG-EAGAQGPP------GPAGPAGERGEQ-GPAGSPGFQG 644

Query: 1943 LSGQAQPP--EGSEDPRGFTESFGAANISQAARER 1975
            L G A PP   G    +G     GA   S A  ER
Sbjct: 645  LPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGER 679



 Score = 32.3 bits (72), Expect = 5.0
 Identities = 35/138 (25%), Positives = 49/138 (35%), Gaps = 12/138 (8%)

Query: 1848 EGQAPPSHSPRGTKRRASWASENGE---TDAEGTQMTPAK--RPALQDSNLAPSLG---- 1898
            +G+A P   PRG++       E G      A G    P    +P  + +N AP +     
Sbjct: 352  KGEAGPQ-GPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPG 410

Query: 1899 -PGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEGSEDPR 1957
             PGA   +  Q P  PP  +  +    A   +   G    PG   + G    P G E  R
Sbjct: 411  FPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQG-PPGPAGEEGKR 469

Query: 1958 GFTESFGAANISQAARER 1975
            G     G   +     ER
Sbjct: 470  GARGEPGPTGLPGPPGER 487


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 40.4 bits (93), Expect = 0.018
 Identities = 35/135 (25%), Positives = 47/135 (34%), Gaps = 27/135 (20%)

Query: 1832 PQARPLEGSSSEDSPP---EGQAPP-----SHSPRGTKRRASWASENGETDAEGTQMTPA 1883
            PQ  P +G +    PP   + Q PP     S SPR    +       G    +G    P 
Sbjct: 78   PQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPG 137

Query: 1884 KRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQL 1943
            K             GP  + G + Q P PP   +     G    D +     S PG+   
Sbjct: 138  K-----------PQGPPPQGGNKPQGPPPPGKPQGPPPQG----DNKSRSSRSPPGKP-- 180

Query: 1944 SGQAQPPEGSEDPRG 1958
              Q  PP+G   P+G
Sbjct: 181  --QGPPPQGGNQPQG 193



 Score = 40.4 bits (93), Expect = 0.018
 Identities = 31/127 (24%), Positives = 46/127 (36%), Gaps = 10/127 (7%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            PQ  P +G +    PP    P    P+G  +  S  S  G+   +G       +P     
Sbjct: 201  PQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGK--PQGPPPQGGNQPQGPPP 258

Query: 1892 NLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPE 1951
                  GP  + G + Q P PP   +     G ++         S PG+     Q  PP+
Sbjct: 259  PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSR----SPPGKP----QGPPPQ 310

Query: 1952 GSEDPRG 1958
            G   P+G
Sbjct: 311  GGNQPQG 317



 Score = 34.3 bits (77), Expect = 1.3
 Identities = 30/126 (23%), Positives = 41/126 (32%), Gaps = 37/126 (29%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            PQ  P +G +    PP    P    P+G  +  S  S  G+                   
Sbjct: 325  PQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQ----------------- 367

Query: 1892 NLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPE 1951
                  GP  ++G   Q P PP       A G  Q+ Q       +P   Q  G  +PP+
Sbjct: 368  ------GPPQQEGNNPQGPPPP-------AGGNPQQPQ-------APPAGQPQGPPRPPQ 407

Query: 1952 GSEDPR 1957
            G    R
Sbjct: 408  GGRPSR 413



 Score = 33.5 bits (75), Expect = 2.3
 Identities = 30/140 (21%), Positives = 44/140 (31%), Gaps = 31/140 (22%)

Query: 1819 LKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGT 1878
            +   E   +   +PQ  P +G +    PP     P   P             G    +G 
Sbjct: 23   VSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPP-----------PQGGNQPQGP 71

Query: 1879 QMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSP 1938
               P K             GP  + G + Q P PP   +     G   +  +     S P
Sbjct: 72   PPPPGK-----------PQGPPPQGGNKPQGPPPPGKPQ-----GPPPQGDKSRSPRSPP 115

Query: 1939 GQEQLSGQAQPPEGSEDPRG 1958
            G+     Q  PP+G   P+G
Sbjct: 116  GKP----QGPPPQGGNQPQG 131



 Score = 33.5 bits (75), Expect = 2.3
 Identities = 29/140 (20%), Positives = 41/140 (29%), Gaps = 36/140 (25%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            PQ  P +G +    PP    P    P+G  +  S  S  G+                   
Sbjct: 139  PQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQ----------------- 181

Query: 1892 NLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQ-------------EGVGEFSSP 1938
                  GP  + G + Q P PPP            + Q             +G  +  S 
Sbjct: 182  ------GPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSA 235

Query: 1939 GQEQLSGQAQPPEGSEDPRG 1958
                   Q  PP+G   P+G
Sbjct: 236  RSPPGKPQGPPPQGGNQPQG 255


>gi|41349486 proline-rich protein BstNI subfamily 1 isoform 3
            preproprotein [Homo sapiens]
          Length = 178

 Score = 40.4 bits (93), Expect = 0.018
 Identities = 36/134 (26%), Positives = 49/134 (36%), Gaps = 23/134 (17%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            PQ  P +G +    PP    P    P+G K R S  S  G+      Q    + P  Q  
Sbjct: 57   PQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSR-SPRSPPGKPQGPPPQGGKPQGPPAQGG 115

Query: 1892 NLAPSL--------GPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQL 1943
            + + S         GP  ++G   Q P PP       A G  Q+ Q       +P   Q 
Sbjct: 116  SKSQSARSPPGKPQGPPQQEGNNPQGPPPP-------AGGNPQQPQ-------APPAGQP 161

Query: 1944 SGQAQPPEGSEDPR 1957
             G  +PP+G    R
Sbjct: 162  QGPPRPPQGGRPSR 175


>gi|7662162 ALEX2 protein [Homo sapiens]
          Length = 632

 Score = 40.4 bits (93), Expect = 0.018
 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 8/134 (5%)

Query: 1833 QARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDSN 1892
            +A+   GS ++++   G  P + S  G    ++ A   G T+A G    PA   A     
Sbjct: 106  EAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGA----- 160

Query: 1893 LAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEG 1952
              P +     +   ++A  PP  +  T AA A  E  EG G  +     +  G A P E 
Sbjct: 161  --PKVAEAPREAETSRAAVPPGTVVPTEAA-APTEVTEGPGVAAPTKVAEAPGVASPTEA 217

Query: 1953 SEDPRGFTESFGAA 1966
            +E P   T +  AA
Sbjct: 218  AEAPVPATPTGAAA 231



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 37/134 (27%), Positives = 54/134 (40%), Gaps = 12/134 (8%)

Query: 1852 PPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAED-GAEAQAP 1910
            P + +  GT  RA      G T   G+  +P      +  + A       +  GAEA AP
Sbjct: 41   PKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAP 100

Query: 1911 SPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQ-----PPEGSEDPRGFTES--- 1962
            +   A    A +GA  + QE  G    P  E + G A      PP G  +  G  E+   
Sbjct: 101  AASSA---EAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAM 157

Query: 1963 FGAANISQAARERD 1976
             GA  +++A RE +
Sbjct: 158  AGAPKVAEAPREAE 171


>gi|29540562 ALEX2 protein [Homo sapiens]
          Length = 632

 Score = 40.4 bits (93), Expect = 0.018
 Identities = 36/134 (26%), Positives = 55/134 (41%), Gaps = 8/134 (5%)

Query: 1833 QARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDSN 1892
            +A+   GS ++++   G  P + S  G    ++ A   G T+A G    PA   A     
Sbjct: 106  EAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAGA----- 160

Query: 1893 LAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQPPEG 1952
              P +     +   ++A  PP  +  T AA A  E  EG G  +     +  G A P E 
Sbjct: 161  --PKVAEAPREAETSRAAVPPGTVVPTEAA-APTEVTEGPGVAAPTKVAEAPGVASPTEA 217

Query: 1953 SEDPRGFTESFGAA 1966
            +E P   T +  AA
Sbjct: 218  AEAPVPATPTGAAA 231



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 37/134 (27%), Positives = 54/134 (40%), Gaps = 12/134 (8%)

Query: 1852 PPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAED-GAEAQAP 1910
            P + +  GT  RA      G T   G+  +P      +  + A       +  GAEA AP
Sbjct: 41   PKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVAP 100

Query: 1911 SPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQ-----PPEGSEDPRGFTES--- 1962
            +   A    A +GA  + QE  G    P  E + G A      PP G  +  G  E+   
Sbjct: 101  AASSA---EAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAM 157

Query: 1963 FGAANISQAARERD 1976
             GA  +++A RE +
Sbjct: 158  AGAPKVAEAPREAE 171


>gi|119395716 forkhead box C1 [Homo sapiens]
          Length = 553

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 31/113 (27%), Positives = 46/113 (40%), Gaps = 7/113 (6%)

Query: 1832 PQARPL--EGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTP---AKRP 1886
            P ARPL  +G+ S   PP   APP H  +G        S  G   +   +++    A   
Sbjct: 278  PSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAELSSGLLASAA 337

Query: 1887 ALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPG 1939
            A   + +AP L  GA    ++   S P     T++AG++     G G     G
Sbjct: 338  ASSRAGIAPPLALGAYSPGQSSLYSSP--CSQTSSAGSSGGGGGGAGAAGGAG 388


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
            [Homo sapiens]
          Length = 1412

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 19/149 (12%)

Query: 1834 ARPLEGSSSEDSPP-EGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQ--- 1889
            A+   G  +  +PP +  A  S +  G     S +S    +D+E  + TPA +  LQ   
Sbjct: 230  AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE--EETPAAKALLQAKA 287

Query: 1890 ---DSNLAPSLGPGAEDGAEAQAPSPP----PALEDTAAAGAAQED-----QEGVGEFSS 1937
                S +  +  P  E   +  AP+PP    PA+   A AG  +ED     +E   E  +
Sbjct: 288  SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA-KAQAGKREEDSQSSSEESDSEEEA 346

Query: 1938 PGQEQLSGQAQPPEGSEDPRGFTESFGAA 1966
            P Q + SG+A     +  P   +   GAA
Sbjct: 347  PAQAKPSGKAPQVRAASAPAKESPRKGAA 375



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 26/147 (17%)

Query: 1823 EDADIQREDPQARPL-----EGSSSE---------DSPPEGQAPPSHSPRGT-------- 1860
            E +D + E P A+ L      G +S+         +SP +G AP      G         
Sbjct: 268  ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 327

Query: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920
            KR     S + E+D+E      AK P+ +   +  +  P  E   +  AP+PP      A
Sbjct: 328  KREEDSQSSSEESDSEEEAPAQAK-PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 386

Query: 1921 A---AGAAQEDQEGVGEFSSPGQEQLS 1944
            A    G  +ED     E S   +E L+
Sbjct: 387  AQVQVGKQEEDSRSSSEESDSDREALA 413



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 40/189 (21%)

Query: 1839 GSSSEDSPPEGQAPPSHSPRGT--KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPS 1896
            GS  +   P+G A  +H+  G    R  +   E     +E   + P++  +L    + P 
Sbjct: 1078 GSEEDGEGPQG-AKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQ--SLLSGYMTPG 1134

Query: 1897 LGPGAEDGAEAQAPSPPPALEDTAAAG---AAQEDQEGVGEFS--------SP---GQEQ 1942
            L P     A +QA    P L+ + +     AA++D +G  E          SP   G+E 
Sbjct: 1135 LTP-----ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEA 1189

Query: 1943 LSGQA-----QPPEGSEDPRGFTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLP 1997
             SG       +P +G+ +P+  T +   +NI+Q          C +G+PW + +  +   
Sbjct: 1190 ASGTTPQKSRKPKKGAGNPQASTLAL-QSNITQ----------CLLGQPWPLNEAQVQAS 1238

Query: 1998 VCKGMMEAM 2006
            V K + E +
Sbjct: 1239 VVKVLTELL 1247



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 27/112 (24%), Positives = 44/112 (39%), Gaps = 1/112 (0%)

Query: 1831 DPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAK-RPALQ 1889
            +PQ   +        P  G+A  + +   T       S   E+D+E    T A+ +P+ +
Sbjct: 756  NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 815

Query: 1890 DSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQE 1941
               +  +L P  E   +  AP+PP     +AA    Q+D     E S    E
Sbjct: 816  THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 867



 Score = 32.7 bits (73), Expect = 3.9
 Identities = 66/329 (20%), Positives = 116/329 (35%), Gaps = 47/329 (14%)

Query: 482  EERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAEE 541
            EE S S      S+++    A ++P  + H     +         P K   P+ PG    
Sbjct: 788  EEDSGSSEEESDSEEEAETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGP 844

Query: 542  RACQSLASRDS---------------LLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRM 586
             A Q+    DS                + ++ V +P + FV              +    
Sbjct: 845  SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 904

Query: 587  ENPKESSSSLKTGRHSSGQDKPHETYRLLK------RRNLIIEAVTNLRLIE-------S 633
              P+++ +S  T R SS + +  +     +      R N++     + R+         S
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 964

Query: 634  LFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVH 693
                   I D +KQEG +T+  KK+   L   L++  L  L          +K  +    
Sbjct: 965  SSKESSRISDGKKQEGPATQVSKKNPASL--PLTQAALKVL---------AQKASEAQPP 1013

Query: 694  PSMDQNDPLVRSAIEQVRFRISNSSTANRVKTSQPPVPQ-GEAEEDSQGKEGPSGSGDSQ 752
             +  Q    V SA+  +      S++     T++   P+  E ++ ++  E    S DS 
Sbjct: 1014 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1073

Query: 753  LSASSRSESGR----MKKSDNKMGITPLR 777
             S+S   E G      K +   +G TP R
Sbjct: 1074 DSSSGSEEDGEGPQGAKSAHTLVGPTPSR 1102


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 19/149 (12%)

Query: 1834 ARPLEGSSSEDSPP-EGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQ--- 1889
            A+   G  +  +PP +  A  S +  G     S +S    +D+E  + TPA +  LQ   
Sbjct: 307  AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE--EETPAAKALLQAKA 364

Query: 1890 ---DSNLAPSLGPGAEDGAEAQAPSPP----PALEDTAAAGAAQED-----QEGVGEFSS 1937
                S +  +  P  E   +  AP+PP    PA+   A AG  +ED     +E   E  +
Sbjct: 365  SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA-KAQAGKREEDSQSSSEESDSEEEA 423

Query: 1938 PGQEQLSGQAQPPEGSEDPRGFTESFGAA 1966
            P Q + SG+A     +  P   +   GAA
Sbjct: 424  PAQAKPSGKAPQVRAASAPAKESPRKGAA 452



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 26/147 (17%)

Query: 1823 EDADIQREDPQARPL-----EGSSSE---------DSPPEGQAPPSHSPRGT-------- 1860
            E +D + E P A+ L      G +S+         +SP +G AP      G         
Sbjct: 345  ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 404

Query: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920
            KR     S + E+D+E      AK P+ +   +  +  P  E   +  AP+PP      A
Sbjct: 405  KREEDSQSSSEESDSEEEAPAQAK-PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 1921 A---AGAAQEDQEGVGEFSSPGQEQLS 1944
            A    G  +ED     E S   +E L+
Sbjct: 464  AQVQVGKQEEDSRSSSEESDSDREALA 490



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 40/189 (21%)

Query: 1839 GSSSEDSPPEGQAPPSHSPRGT--KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPS 1896
            GS  +   P+G A  +H+  G    R  +   E     +E   + P++  +L    + P 
Sbjct: 1117 GSEEDGEGPQG-AKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQ--SLLSGYMTPG 1173

Query: 1897 LGPGAEDGAEAQAPSPPPALEDTAAAG---AAQEDQEGVGEFS--------SP---GQEQ 1942
            L P     A +QA    P L+ + +     AA++D +G  E          SP   G+E 
Sbjct: 1174 LTP-----ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEA 1228

Query: 1943 LSGQA-----QPPEGSEDPRGFTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLP 1997
             SG       +P +G+ +P+  T +   +NI+Q          C +G+PW + +  +   
Sbjct: 1229 ASGTTPQKSRKPKKGAGNPQASTLAL-QSNITQ----------CLLGQPWPLNEAQVQAS 1277

Query: 1998 VCKGMMEAM 2006
            V K + E +
Sbjct: 1278 VVKVLTELL 1286



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 27/112 (24%), Positives = 44/112 (39%), Gaps = 1/112 (0%)

Query: 1831 DPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAK-RPALQ 1889
            +PQ   +        P  G+A  + +   T       S   E+D+E    T A+ +P+ +
Sbjct: 833  NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 892

Query: 1890 DSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQE 1941
               +  +L P  E   +  AP+PP     +AA    Q+D     E S    E
Sbjct: 893  THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
            [Homo sapiens]
          Length = 1488

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 19/149 (12%)

Query: 1834 ARPLEGSSSEDSPP-EGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQ--- 1889
            A+   G  +  +PP +  A  S +  G     S +S    +D+E  + TPA +  LQ   
Sbjct: 307  AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE--EETPAAKALLQAKA 364

Query: 1890 ---DSNLAPSLGPGAEDGAEAQAPSPP----PALEDTAAAGAAQED-----QEGVGEFSS 1937
                S +  +  P  E   +  AP+PP    PA+   A AG  +ED     +E   E  +
Sbjct: 365  SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA-KAQAGKREEDSQSSSEESDSEEEA 423

Query: 1938 PGQEQLSGQAQPPEGSEDPRGFTESFGAA 1966
            P Q + SG+A     +  P   +   GAA
Sbjct: 424  PAQAKPSGKAPQVRAASAPAKESPRKGAA 452



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 48/188 (25%), Positives = 79/188 (42%), Gaps = 39/188 (20%)

Query: 1839 GSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQM-TPAKRPALQDSNLAPSL 1897
            GS  +   P+G A  +H+   T  R     E  ET AE ++    A   +L    + P L
Sbjct: 1155 GSEEDGEGPQG-AKSAHTLGPTPSRTETLVE--ETAAESSEDDVVAPSQSLLSGYMTPGL 1211

Query: 1898 GPGAEDGAEAQAPSPPPALEDTAAAG---AAQEDQEGVGEFS--------SP---GQEQL 1943
             P     A +QA    P L+ + +     AA++D +G  E          SP   G+E  
Sbjct: 1212 TP-----ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAA 1266

Query: 1944 SGQA-----QPPEGSEDPRGFTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLPV 1998
            SG       +P +G+ +P+  T +   +NI+Q          C +G+PW + +  +   V
Sbjct: 1267 SGTTPQKSRKPKKGAGNPQASTLAL-QSNITQ----------CLLGQPWPLNEAQVQASV 1315

Query: 1999 CKGMMEAM 2006
             K + E +
Sbjct: 1316 VKVLTELL 1323



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 26/147 (17%)

Query: 1823 EDADIQREDPQARPL-----EGSSSE---------DSPPEGQAPPSHSPRGT-------- 1860
            E +D + E P A+ L      G +S+         +SP +G AP      G         
Sbjct: 345  ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 404

Query: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920
            KR     S + E+D+E      AK P+ +   +  +  P  E   +  AP+PP      A
Sbjct: 405  KREEDSQSSSEESDSEEEAPAQAK-PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 1921 A---AGAAQEDQEGVGEFSSPGQEQLS 1944
            A    G  +ED     E S   +E L+
Sbjct: 464  AQVQVGKQEEDSRSSSEESDSDREALA 490



 Score = 34.3 bits (77), Expect = 1.3
 Identities = 67/328 (20%), Positives = 118/328 (35%), Gaps = 46/328 (14%)

Query: 482  EERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAEE 541
            EE S S      S+++    A ++P  + H     +         P K   P+ PG    
Sbjct: 865  EEDSGSSEEESDSEEEAETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGP 921

Query: 542  RACQSLASRDS---------------LLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRM 586
             A Q+    DS                + ++ V +P + FV              +    
Sbjct: 922  SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 981

Query: 587  ENPKESSSSLKTGRHSSGQDKPHETYRLLK------RRNLIIEAVTNLRLIE-------S 633
              P+++ +S  T R SS + +  +     +      R N++     + R+         S
Sbjct: 982  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 1041

Query: 634  LFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVH 693
                   I D +KQEG +T+  KK+   L   L++  L  L          +K  +    
Sbjct: 1042 SSKESSRISDGKKQEGPATQVSKKNPASL--PLTQAALKVL---------AQKASEAQPP 1090

Query: 694  PSMDQNDPLVRSAIEQVRFRISNSSTANRVKTSQPPVPQ-GEAEEDSQGKEGPSGSGDSQ 752
             +  Q    V SA+  +      S++     T++   P+  E ++ ++  E    S DS 
Sbjct: 1091 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1150

Query: 753  LSASSRSESG---RMKKSDNKMGITPLR 777
             S+S   E G   +  KS + +G TP R
Sbjct: 1151 DSSSGSEEDGEGPQGAKSAHTLGPTPSR 1178



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 27/112 (24%), Positives = 44/112 (39%), Gaps = 1/112 (0%)

Query: 1831 DPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAK-RPALQ 1889
            +PQ   +        P  G+A  + +   T       S   E+D+E    T A+ +P+ +
Sbjct: 833  NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 892

Query: 1890 DSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQE 1941
               +  +L P  E   +  AP+PP     +AA    Q+D     E S    E
Sbjct: 893  THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
            sapiens]
          Length = 1411

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 19/149 (12%)

Query: 1834 ARPLEGSSSEDSPP-EGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQ--- 1889
            A+   G  +  +PP +  A  S +  G     S +S    +D+E  + TPA +  LQ   
Sbjct: 230  AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE--EETPAAKALLQAKA 287

Query: 1890 ---DSNLAPSLGPGAEDGAEAQAPSPP----PALEDTAAAGAAQED-----QEGVGEFSS 1937
                S +  +  P  E   +  AP+PP    PA+   A AG  +ED     +E   E  +
Sbjct: 288  SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA-KAQAGKREEDSQSSSEESDSEEEA 346

Query: 1938 PGQEQLSGQAQPPEGSEDPRGFTESFGAA 1966
            P Q + SG+A     +  P   +   GAA
Sbjct: 347  PAQAKPSGKAPQVRAASAPAKESPRKGAA 375



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 48/188 (25%), Positives = 79/188 (42%), Gaps = 39/188 (20%)

Query: 1839 GSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQM-TPAKRPALQDSNLAPSL 1897
            GS  +   P+G A  +H+   T  R     E  ET AE ++    A   +L    + P L
Sbjct: 1078 GSEEDGEGPQG-AKSAHTLGPTPSRTETLVE--ETAAESSEDDVVAPSQSLLSGYMTPGL 1134

Query: 1898 GPGAEDGAEAQAPSPPPALEDTAAAG---AAQEDQEGVGEFS--------SP---GQEQL 1943
             P     A +QA    P L+ + +     AA++D +G  E          SP   G+E  
Sbjct: 1135 TP-----ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAA 1189

Query: 1944 SGQA-----QPPEGSEDPRGFTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLPV 1998
            SG       +P +G+ +P+  T +   +NI+Q          C +G+PW + +  +   V
Sbjct: 1190 SGTTPQKSRKPKKGAGNPQASTLAL-QSNITQ----------CLLGQPWPLNEAQVQASV 1238

Query: 1999 CKGMMEAM 2006
             K + E +
Sbjct: 1239 VKVLTELL 1246



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 26/147 (17%)

Query: 1823 EDADIQREDPQARPL-----EGSSSE---------DSPPEGQAPPSHSPRGT-------- 1860
            E +D + E P A+ L      G +S+         +SP +G AP      G         
Sbjct: 268  ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 327

Query: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920
            KR     S + E+D+E      AK P+ +   +  +  P  E   +  AP+PP      A
Sbjct: 328  KREEDSQSSSEESDSEEEAPAQAK-PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 386

Query: 1921 A---AGAAQEDQEGVGEFSSPGQEQLS 1944
            A    G  +ED     E S   +E L+
Sbjct: 387  AQVQVGKQEEDSRSSSEESDSDREALA 413



 Score = 34.3 bits (77), Expect = 1.3
 Identities = 67/328 (20%), Positives = 118/328 (35%), Gaps = 46/328 (14%)

Query: 482  EERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAEE 541
            EE S S      S+++    A ++P  + H     +         P K   P+ PG    
Sbjct: 788  EEDSGSSEEESDSEEEAETLAQVKPSGKTHQ---IRAALAPAKESPRKGAAPTPPGKTGP 844

Query: 542  RACQSLASRDS---------------LLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRM 586
             A Q+    DS                + ++ V +P + FV              +    
Sbjct: 845  SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 904

Query: 587  ENPKESSSSLKTGRHSSGQDKPHETYRLLK------RRNLIIEAVTNLRLIE-------S 633
              P+++ +S  T R SS + +  +     +      R N++     + R+         S
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 964

Query: 634  LFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYRTTVIQDGIKKKVDLVVH 693
                   I D +KQEG +T+  KK+   L   L++  L  L          +K  +    
Sbjct: 965  SSKESSRISDGKKQEGPATQVSKKNPASL--PLTQAALKVL---------AQKASEAQPP 1013

Query: 694  PSMDQNDPLVRSAIEQVRFRISNSSTANRVKTSQPPVPQ-GEAEEDSQGKEGPSGSGDSQ 752
             +  Q    V SA+  +      S++     T++   P+  E ++ ++  E    S DS 
Sbjct: 1014 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1073

Query: 753  LSASSRSESG---RMKKSDNKMGITPLR 777
             S+S   E G   +  KS + +G TP R
Sbjct: 1074 DSSSGSEEDGEGPQGAKSAHTLGPTPSR 1101



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 27/112 (24%), Positives = 44/112 (39%), Gaps = 1/112 (0%)

Query: 1831 DPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAK-RPALQ 1889
            +PQ   +        P  G+A  + +   T       S   E+D+E    T A+ +P+ +
Sbjct: 756  NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 815

Query: 1890 DSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQE 1941
               +  +L P  E   +  AP+PP     +AA    Q+D     E S    E
Sbjct: 816  THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 867


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
            sapiens]
          Length = 1450

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 19/149 (12%)

Query: 1834 ARPLEGSSSEDSPP-EGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQ--- 1889
            A+   G  +  +PP +  A  S +  G     S +S    +D+E  + TPA +  LQ   
Sbjct: 307  AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE--EETPAAKALLQAKA 364

Query: 1890 ---DSNLAPSLGPGAEDGAEAQAPSPP----PALEDTAAAGAAQED-----QEGVGEFSS 1937
                S +  +  P  E   +  AP+PP    PA+   A AG  +ED     +E   E  +
Sbjct: 365  SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA-KAQAGKREEDSQSSSEESDSEEEA 423

Query: 1938 PGQEQLSGQAQPPEGSEDPRGFTESFGAA 1966
            P Q + SG+A     +  P   +   GAA
Sbjct: 424  PAQAKPSGKAPQVRAASAPAKESPRKGAA 452



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 48/188 (25%), Positives = 79/188 (42%), Gaps = 39/188 (20%)

Query: 1839 GSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQM-TPAKRPALQDSNLAPSL 1897
            GS  +   P+G A  +H+   T  R     E  ET AE ++    A   +L    + P L
Sbjct: 1117 GSEEDGEGPQG-AKSAHTLGPTPSRTETLVE--ETAAESSEDDVVAPSQSLLSGYMTPGL 1173

Query: 1898 GPGAEDGAEAQAPSPPPALEDTAAAG---AAQEDQEGVGEFS--------SP---GQEQL 1943
             P     A +QA    P L+ + +     AA++D +G  E          SP   G+E  
Sbjct: 1174 TP-----ANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAA 1228

Query: 1944 SGQA-----QPPEGSEDPRGFTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLPV 1998
            SG       +P +G+ +P+  T +   +NI+Q          C +G+PW + +  +   V
Sbjct: 1229 SGTTPQKSRKPKKGAGNPQASTLAL-QSNITQ----------CLLGQPWPLNEAQVQASV 1277

Query: 1999 CKGMMEAM 2006
             K + E +
Sbjct: 1278 VKVLTELL 1285



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 26/147 (17%)

Query: 1823 EDADIQREDPQARPL-----EGSSSE---------DSPPEGQAPPSHSPRGT-------- 1860
            E +D + E P A+ L      G +S+         +SP +G AP      G         
Sbjct: 345  ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 404

Query: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920
            KR     S + E+D+E      AK P+ +   +  +  P  E   +  AP+PP      A
Sbjct: 405  KREEDSQSSSEESDSEEEAPAQAK-PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 1921 A---AGAAQEDQEGVGEFSSPGQEQLS 1944
            A    G  +ED     E S   +E L+
Sbjct: 464  AQVQVGKQEEDSRSSSEESDSDREALA 490



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 27/112 (24%), Positives = 44/112 (39%), Gaps = 1/112 (0%)

Query: 1831 DPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAK-RPALQ 1889
            +PQ   +        P  G+A  + +   T       S   E+D+E    T A+ +P+ +
Sbjct: 833  NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 892

Query: 1890 DSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQE 1941
               +  +L P  E   +  AP+PP     +AA    Q+D     E S    E
Sbjct: 893  THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo
            sapiens]
          Length = 958

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 19/149 (12%)

Query: 1834 ARPLEGSSSEDSPP-EGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQ--- 1889
            A+   G  +  +PP +  A  S +  G     S +S    +D+E  + TPA +  LQ   
Sbjct: 307  AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE--EETPAAKALLQAKA 364

Query: 1890 ---DSNLAPSLGPGAEDGAEAQAPSPP----PALEDTAAAGAAQED-----QEGVGEFSS 1937
                S +  +  P  E   +  AP+PP    PA+   A AG  +ED     +E   E  +
Sbjct: 365  SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA-KAQAGKREEDSQSSSEESDSEEEA 423

Query: 1938 PGQEQLSGQAQPPEGSEDPRGFTESFGAA 1966
            P Q + SG+A     +  P   +   GAA
Sbjct: 424  PAQAKPSGKAPQVRAASAPAKESPRKGAA 452



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 38/147 (25%), Positives = 57/147 (38%), Gaps = 26/147 (17%)

Query: 1823 EDADIQREDPQARPL-----EGSSSE---------DSPPEGQAPPSHSPRGT-------- 1860
            E +D + E P A+ L      G +S+         +SP +G AP      G         
Sbjct: 345  ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 404

Query: 1861 KRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTA 1920
            KR     S + E+D+E      AK P+ +   +  +  P  E   +  AP+PP      A
Sbjct: 405  KREEDSQSSSEESDSEEEAPAQAK-PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463

Query: 1921 A---AGAAQEDQEGVGEFSSPGQEQLS 1944
            A    G  +ED     E S   +E L+
Sbjct: 464  AQVQVGKQEEDSRSSSEESDSDREALA 490



 Score = 33.9 bits (76), Expect = 1.7
 Identities = 27/112 (24%), Positives = 44/112 (39%), Gaps = 1/112 (0%)

Query: 1831 DPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAK-RPALQ 1889
            +PQ   +        P  G+A  + +   T       S   E+D+E    T A+ +P+ +
Sbjct: 833  NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 892

Query: 1890 DSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQE 1941
               +  +L P  E   +  AP+PP     +AA    Q+D     E S    E
Sbjct: 893  THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944


>gi|146219832 myosin light chain kinase 3 [Homo sapiens]
          Length = 819

 Score = 39.3 bits (90), Expect = 0.041
 Identities = 33/122 (27%), Positives = 44/122 (36%), Gaps = 5/122 (4%)

Query: 1831 DPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQD 1890
            DP    +     +  P   QA P H P  TK  A       E    G ++ PA     + 
Sbjct: 215  DPAQAVVSPGQGDGVPGPAQAFPGHLPLPTKVEAKAPETPSENLRTGLELAPAPG---RV 271

Query: 1891 SNLAPSL--GPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQ 1948
            + ++PSL   PGA  GA +  P P P  E T           G     +  +   SG   
Sbjct: 272  NVVSPSLEVAPGAGQGASSSRPDPEPLEEGTRLTPGPGPQCPGPPGLPAQARATHSGGET 331

Query: 1949 PP 1950
            PP
Sbjct: 332  PP 333


>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
          Length = 1505

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 45/181 (24%), Positives = 69/181 (38%), Gaps = 22/181 (12%)

Query: 1815 HSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPS------HSPRGTKRRASWAS 1868
            H+ R + R +  I+     ++   G+S   S   G+A PS           T+   S  +
Sbjct: 1293 HNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADT 1352

Query: 1869 ENGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDG---------AEAQAPSPPPALEDT 1919
            E  ++  E  +     RPA + +   PS  PG +D           E   P P PA    
Sbjct: 1353 EEPKSQGE-AEREEVPRPA-EQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATA 1410

Query: 1920 AAAGAAQEDQEGVGEFSSPGQEQLSGQAQPP----EGSEDPRGFTESFGAANISQAARER 1975
             AA AA ED       ++PG+   +  + PP      S  PR  +       + +AA  R
Sbjct: 1411 TAAPAAPED-AATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGAR 1469

Query: 1976 D 1976
            D
Sbjct: 1470 D 1470


>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
            isoform 1 [Homo sapiens]
          Length = 1599

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 7/164 (4%)

Query: 1811 PWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASE- 1869
            P   H+V + +  +  +  ED +  P   SS E +PP   A PS SP      A      
Sbjct: 350  PLASHTVEIHE-PNGMVPSEDLE--PEVESSPELAPPP--ACPSESPVPIAPTAQPEELL 404

Query: 1870 NGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAE-AQAPSPPPALEDTAAAGAAQED 1928
            NG        ++P   P  Q   +  S+ P     A  A APS     ++       +E+
Sbjct: 405  NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE 464

Query: 1929 QEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAA 1972
            +   GE      E+   +  PPE +  P   +++  AA  +Q A
Sbjct: 465  EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVA 508


>gi|38201627 eukaryotic translation initiation factor 4 gamma, 1
            isoform 2 [Homo sapiens]
          Length = 1512

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 7/164 (4%)

Query: 1811 PWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASE- 1869
            P   H+V + +  +  +  ED +  P   SS E +PP   A PS SP      A      
Sbjct: 263  PLASHTVEIHE-PNGMVPSEDLE--PEVESSPELAPPP--ACPSESPVPIAPTAQPEELL 317

Query: 1870 NGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAE-AQAPSPPPALEDTAAAGAAQED 1928
            NG        ++P   P  Q   +  S+ P     A  A APS     ++       +E+
Sbjct: 318  NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE 377

Query: 1929 QEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAA 1972
            +   GE      E+   +  PPE +  P   +++  AA  +Q A
Sbjct: 378  EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVA 421


>gi|38201625 eukaryotic translation initiation factor 4 gamma, 1
            isoform 3 [Homo sapiens]
          Length = 1435

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 7/164 (4%)

Query: 1811 PWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASE- 1869
            P   H+V + +  +  +  ED +  P   SS E +PP   A PS SP      A      
Sbjct: 186  PLASHTVEIHE-PNGMVPSEDLE--PEVESSPELAPPP--ACPSESPVPIAPTAQPEELL 240

Query: 1870 NGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAE-AQAPSPPPALEDTAAAGAAQED 1928
            NG        ++P   P  Q   +  S+ P     A  A APS     ++       +E+
Sbjct: 241  NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE 300

Query: 1929 QEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAA 1972
            +   GE      E+   +  PPE +  P   +++  AA  +Q A
Sbjct: 301  EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVA 344


>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
            isoform 1 [Homo sapiens]
          Length = 1599

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 7/164 (4%)

Query: 1811 PWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASE- 1869
            P   H+V + +  +  +  ED +  P   SS E +PP   A PS SP      A      
Sbjct: 350  PLASHTVEIHE-PNGMVPSEDLE--PEVESSPELAPPP--ACPSESPVPIAPTAQPEELL 404

Query: 1870 NGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAE-AQAPSPPPALEDTAAAGAAQED 1928
            NG        ++P   P  Q   +  S+ P     A  A APS     ++       +E+
Sbjct: 405  NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE 464

Query: 1929 QEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAA 1972
            +   GE      E+   +  PPE +  P   +++  AA  +Q A
Sbjct: 465  EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVA 508


>gi|38201619 eukaryotic translation initiation factor 4 gamma, 1
            isoform 4 [Homo sapiens]
          Length = 1403

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 7/164 (4%)

Query: 1811 PWLLHSVRLKDREDADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASE- 1869
            P   H+V + +  +  +  ED +  P   SS E +PP   A PS SP      A      
Sbjct: 154  PLASHTVEIHE-PNGMVPSEDLE--PEVESSPELAPPP--ACPSESPVPIAPTAQPEELL 208

Query: 1870 NGETDAEGTQMTPAKRPALQDSNLAPSLGPGAEDGAE-AQAPSPPPALEDTAAAGAAQED 1928
            NG        ++P   P  Q   +  S+ P     A  A APS     ++       +E+
Sbjct: 209  NGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEE 268

Query: 1929 QEGVGEFSSPGQEQLSGQAQPPEGSEDPRGFTESFGAANISQAA 1972
            +   GE      E+   +  PPE +  P   +++  AA  +Q A
Sbjct: 269  EGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVA 312


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 38/146 (26%), Positives = 56/146 (38%), Gaps = 18/146 (12%)

Query: 1821 DREDADIQREDPQARP-LEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQ 1879
            + E  +    + +A+P  EG  ++D+  E Q      P      A  A E  + + EG +
Sbjct: 2128 ESEGIEAPEAEGEAQPESEGVEAQDAEGEAQ------PESEGIEAQEAEEEAQPELEGVE 2181

Query: 1880 MTPAKRPALQDSN----------LAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQ 1929
               A+  A  +S             P L       AE +A   P  +E   A G AQ + 
Sbjct: 2182 APEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPES 2241

Query: 1930 EGVGEFSSPGQEQLS-GQAQPPEGSE 1954
            EG  +    G  Q+S G  Q  E SE
Sbjct: 2242 EGETQGEKKGSPQVSLGDGQSEEASE 2267



 Score = 37.4 bits (85), Expect = 0.16
 Identities = 52/210 (24%), Positives = 77/210 (36%), Gaps = 40/210 (19%)

Query: 1775 GRTRTFADCIQALLEQHQVLEVGGNTARLVAMGSAWPWLLHSVRLKDREDADIQREDPQA 1834
            G  +  +D ++A   + +  E  G      A G A P         + ED D Q  + +A
Sbjct: 2046 GDAQPESDGVEAPEAEEEAQEAEGEVQE--AEGEAHP---------ESEDVDAQEAEGEA 2094

Query: 1835 RPLEGSSSEDSPPEGQAPPSHS-----------PRGTKRRASWASENGETDAEGTQMTPA 1883
            +P E    E    EG+A  +             P      A  A    + ++EG +   A
Sbjct: 2095 QP-ESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153

Query: 1884 KRPALQDSN----------LAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVG 1933
            +  A  +S             P L       AE +A      +E   A G AQ + EGV 
Sbjct: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGV- 2212

Query: 1934 EFSSPGQEQLSGQAQP-PEGSEDPRGFTES 1962
               +P  E+   +AQP PEG E P    E+
Sbjct: 2213 --EAPEAEE---EAQPEPEGVETPEAEGEA 2237



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 44/163 (26%), Positives = 64/163 (39%), Gaps = 27/163 (16%)

Query: 1805 AMGSAWPWLLHSVRLKDREDAD-IQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRR 1863
            A G   P L     + + ED +  QR +    P  G +  D+  + +   +H+       
Sbjct: 1726 AEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSE----- 1780

Query: 1864 ASWASENGETDAEGTQMTPAKRPALQDSNLAPSL----------GPGAEDGAEAQAPSPP 1913
             S  SE GE + EG  ++       Q S    +L           PG  DGAE       
Sbjct: 1781 TSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEG------ 1834

Query: 1914 PALEDTAAAGAAQEDQEGVGEFSSPGQ-EQLSGQAQPPEGSED 1955
              +E   A G AQ + EGV    + G  ++  G+AQP   SED
Sbjct: 1835 --IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPE--SED 1873



 Score = 32.7 bits (73), Expect = 3.9
 Identities = 38/139 (27%), Positives = 53/139 (38%), Gaps = 17/139 (12%)

Query: 1824 DADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPA 1883
            +A  + ED +A   EG   E    E +A P     G + +     E  +     TQ T  
Sbjct: 1992 EAQPESEDVEAPEAEGEMQE---AEEEAQPESD--GVEAQPKSEGEEAQEVEGETQKTEG 2046

Query: 1884 KRPALQDSNLAPSLGPGAEDG------AEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSS 1937
                  D   AP     A++       AE +A      ++   A G AQ + EGV    +
Sbjct: 2047 DAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGV---EA 2103

Query: 1938 PGQEQLSGQAQPPEGSEDP 1956
            P  E   G+AQ  EG E P
Sbjct: 2104 PEAE---GEAQKAEGIEAP 2119



 Score = 32.3 bits (72), Expect = 5.0
 Identities = 37/169 (21%), Positives = 56/169 (33%), Gaps = 27/169 (15%)

Query: 1841 SSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDSNLAPSLGPG 1900
            SS  SP  G+  P   PR +  R    S    +  +     P +R A QD ++    G  
Sbjct: 649  SSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSS 708

Query: 1901 AEDGAEAQAPSPP--------------------PALEDTAAAGAAQEDQEGVGEFSSPGQ 1940
            +    +A     P                    PA+     +G +  +    G     G 
Sbjct: 709  SSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGS 768

Query: 1941 EQLSGQAQPPEGSEDPRGFTESFGAANISQAARERDCES---VCFIGRP 1986
               S    PP  S+         GAA++ + AR+    S   V  +GRP
Sbjct: 769  RTCSPAPIPPHTSDS----CSKSGAASLGEEARDTPQPSSPLVLQVGRP 813



 Score = 32.0 bits (71), Expect = 6.6
 Identities = 30/131 (22%), Positives = 52/131 (39%), Gaps = 6/131 (4%)

Query: 1824 DADIQREDPQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPA 1883
            + D Q  + +A+P E    E    EG+A P      T   A W  +    ++EG +   A
Sbjct: 1857 EGDAQEAEGEAQP-ESEDVEAPEAEGEAQPESEDVETPE-AEWEVQ---PESEGAEAPEA 1911

Query: 1884 KRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQL 1943
            ++ A  ++    +L    ED  E++      A E+ A     Q   E     S   +E+ 
Sbjct: 1912 EKEAQPETESVEALETEGEDEPESEGAEAQEA-EEAAQEAEGQTQPESEVIESQEAEEEA 1970

Query: 1944 SGQAQPPEGSE 1954
              +++  E  E
Sbjct: 1971 QPESEDVEALE 1981


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
            preproprotein [Homo sapiens]
          Length = 331

 Score = 38.9 bits (89), Expect = 0.054
 Identities = 31/129 (24%), Positives = 49/129 (37%), Gaps = 6/129 (4%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            PQ  P +G      PP    P    P+G K R   +S++     +G       +P     
Sbjct: 179  PQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSR---SSQSPPGKPQGPPPQGGNQPQGPPP 235

Query: 1892 NLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGA--AQEDQEGVGEFSSPGQEQLSG-QAQ 1948
                  GP  + G + Q P PP   +   A G   +Q  +   G+   P Q++ +  Q  
Sbjct: 236  PPGKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGP 295

Query: 1949 PPEGSEDPR 1957
            PP    +P+
Sbjct: 296  PPPAGGNPQ 304



 Score = 38.1 bits (87), Expect = 0.092
 Identities = 34/135 (25%), Positives = 46/135 (34%), Gaps = 28/135 (20%)

Query: 1832 PQARPLEGSSSEDSPP---EGQAPP-----SHSPRGTKRRASWASENGETDAEGTQMTPA 1883
            PQ  P +G +    PP   + Q PP     S SPR    +       G    +G    P 
Sbjct: 57   PQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPG 116

Query: 1884 KRPALQDSNLAPSLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQL 1943
            K             GP  + G   Q P PP   +     G   +  +     S PG+   
Sbjct: 117  K-----------PQGPPPQGGNRPQGPPPPGKPQ-----GPPPQGDKSRSPRSPPGKP-- 158

Query: 1944 SGQAQPPEGSEDPRG 1958
              Q  PP+G   P+G
Sbjct: 159  --QGPPPQGGNQPQG 171



 Score = 36.6 bits (83), Expect = 0.27
 Identities = 34/129 (26%), Positives = 47/129 (36%), Gaps = 22/129 (17%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            PQ  P +G +    PP    PP   P+G   +       G       Q  PA+  +   S
Sbjct: 219  PQGPPPQGGNQPQGPP----PPPGKPQGPPPQGG-NKPQGPPPPGKPQGPPAQGGSKSQS 273

Query: 1892 NLAP---SLGPGAEDGAEAQAPSPPPALEDTAAAGAAQEDQEGVGEFSSPGQEQLSGQAQ 1948
              +P     GP  ++G   Q P PP       A G  Q+ Q       +P   Q  G  +
Sbjct: 274  ARSPPGKPQGPPQQEGNNPQGPPPP-------AGGNPQQPQ-------APPAGQPQGPPR 319

Query: 1949 PPEGSEDPR 1957
            PP+G    R
Sbjct: 320  PPQGGRPSR 328



 Score = 34.3 bits (77), Expect = 1.3
 Identities = 32/139 (23%), Positives = 45/139 (32%), Gaps = 15/139 (10%)

Query: 1832 PQARPLEGSSSEDSPPEGQAPPSHSPRGTKRRASWASENGETDAEGTQMTPAKRPALQDS 1891
            PQ  P +G +    PP     P   P     R       G+      Q   ++ P    S
Sbjct: 97   PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPR---S 153

Query: 1892 NLAPSLGPGAEDGAEAQAPSPPPALED--TAAAGAAQEDQEGVGEFSSP---GQEQLSGQ 1946
                  GP  + G + Q P PPP          G   +     G+   P   G +  S Q
Sbjct: 154  PPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQ 213

Query: 1947 A-------QPPEGSEDPRG 1958
            +        PP+G   P+G
Sbjct: 214  SPPGKPQGPPPQGGNQPQG 232


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,043,295
Number of Sequences: 37866
Number of extensions: 4118441
Number of successful extensions: 20800
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 314
Number of HSP's that attempted gapping in prelim test: 19667
Number of HSP's gapped (non-prelim): 1526
length of query: 2109
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1991
effective length of database: 13,779,330
effective search space: 27434646030
effective search space used: 27434646030
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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