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Search of human proteins with 171846278
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens]
(2527 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens] 5027 0.0
gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens] 420 e-117
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 127 1e-28
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 109 4e-23
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 107 1e-22
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 107 1e-22
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 107 1e-22
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 107 1e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 106 3e-22
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 104 1e-21
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 104 1e-21
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 104 1e-21
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 104 1e-21
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 101 8e-21
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 100 2e-20
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 100 2e-20
gi|115529463 protein kinase D1 [Homo sapiens] 98 1e-19
gi|5031689 protein kinase D3 [Homo sapiens] 96 3e-19
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 96 4e-19
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 96 4e-19
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 96 4e-19
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 96 4e-19
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 95 8e-19
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 95 1e-18
gi|45827729 scribble isoform b [Homo sapiens] 94 2e-18
gi|45827731 scribble isoform a [Homo sapiens] 94 2e-18
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 94 2e-18
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 93 3e-18
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 92 6e-18
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 92 6e-18
>gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens]
Length = 2527
Score = 5028 bits (13041), Expect = 0.0
Identities = 2527/2527 (100%), Positives = 2527/2527 (100%)
Query: 1 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI 60
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
Sbjct: 1 MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI 60
Query: 61 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK
Sbjct: 61 HVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILK 120
Query: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180
MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG
Sbjct: 121 MLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLG 180
Query: 181 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE 240
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
Sbjct: 181 CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE 240
Query: 241 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ 300
VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
Sbjct: 241 VLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ 300
Query: 301 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH 360
QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH
Sbjct: 301 QYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWH 360
Query: 361 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN 420
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
Sbjct: 361 RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN 420
Query: 421 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM 480
ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM
Sbjct: 421 ALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIM 480
Query: 481 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN 540
AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN
Sbjct: 481 AAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN 540
Query: 541 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ 600
DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ
Sbjct: 541 DIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQ 600
Query: 601 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA 660
EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA
Sbjct: 601 EIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSA 660
Query: 661 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN 720
SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN
Sbjct: 661 SFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQN 720
Query: 721 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG 780
NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
Sbjct: 721 NSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG 780
Query: 781 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA 840
KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
Sbjct: 781 KGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA 840
Query: 841 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG 900
RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
Sbjct: 841 RMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG 900
Query: 901 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR 960
SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR
Sbjct: 901 SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLR 960
Query: 961 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ 1020
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ
Sbjct: 961 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ 1020
Query: 1021 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV 1080
NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV
Sbjct: 1021 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV 1080
Query: 1081 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH 1140
KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
Sbjct: 1081 KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNH 1140
Query: 1141 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS 1200
ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS
Sbjct: 1141 ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS 1200
Query: 1201 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI 1260
LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
Sbjct: 1201 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI 1260
Query: 1261 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR 1320
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
Sbjct: 1261 PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR 1320
Query: 1321 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI 1380
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
Sbjct: 1321 FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI 1380
Query: 1381 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA 1440
RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
Sbjct: 1381 RDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA 1440
Query: 1441 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL 1500
RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL
Sbjct: 1441 RASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKL 1500
Query: 1501 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN 1560
RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN
Sbjct: 1501 RKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVREN 1560
Query: 1561 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK 1620
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
Sbjct: 1561 QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK 1620
Query: 1621 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI 1680
HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
Sbjct: 1621 HPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI 1680
Query: 1681 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL 1740
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
Sbjct: 1681 ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL 1740
Query: 1741 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI 1800
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
Sbjct: 1741 NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI 1800
Query: 1801 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI 1860
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
Sbjct: 1801 CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI 1860
Query: 1861 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE 1920
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
Sbjct: 1861 LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE 1920
Query: 1921 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD 1980
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
Sbjct: 1921 LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD 1980
Query: 1981 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA 2040
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
Sbjct: 1981 GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA 2040
Query: 2041 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG 2100
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG
Sbjct: 2041 PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYG 2100
Query: 2101 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH 2160
CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH
Sbjct: 2101 CAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH 2160
Query: 2161 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ 2220
NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ
Sbjct: 2161 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQ 2220
Query: 2221 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV 2280
SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV
Sbjct: 2221 SGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTV 2280
Query: 2281 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT 2340
KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
Sbjct: 2281 KLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT 2340
Query: 2341 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE 2400
SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE
Sbjct: 2341 SQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKE 2400
Query: 2401 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT 2460
NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT
Sbjct: 2401 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMT 2460
Query: 2461 AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK 2520
AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK
Sbjct: 2461 AQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEK 2520
Query: 2521 MRRTSVE 2527
MRRTSVE
Sbjct: 2521 MRRTSVE 2527
>gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens]
Length = 2015
Score = 420 bits (1080), Expect = e-117
Identities = 385/1440 (26%), Positives = 658/1440 (45%), Gaps = 212/1440 (14%)
Query: 984 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFP--QQLCETLKS-LTHL 1040
IT LDLSAN L + ++ I L +L KL L N L P Q E + S L +
Sbjct: 280 ITELDLSANCLATLPSV-----IPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEI 334
Query: 1041 DLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPE 1100
D+ SNK + P L +S + L S+N + + F E
Sbjct: 335 DISSNKLSHLPPGFLHLSKLQKLTASKNCL-----------------------EKLFEEE 371
Query: 1101 NLTDVV--EKLEQLILEGNKISGICSPL--RLKELKILNLSKNHISSLSENFLEACPKVE 1156
N T+ + KL++L + NK++ + + K L LN+S+N++ + + ACP ++
Sbjct: 372 NATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPW--ACP-LK 428
Query: 1157 SFSARMNFLAAMP-----FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 1211
A N L +P F + + S+N +P + L L L + N + L
Sbjct: 429 CCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAAL 488
Query: 1212 PGPAHWKSLNLRELLFSHNQI----------------------------SILDLSEKAYL 1243
P W L+ L S NQ+ S+L+ A+L
Sbjct: 489 PPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFP--AFL 546
Query: 1244 WSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELH 1303
+E L L+ N L +PP + L++L+ L + N LR P E+G+L +W L ++L
Sbjct: 547 SESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLT 606
Query: 1304 LN---FDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKS 1360
++ + + G KA ++ +L+ +L+KA MK++IVG GK+TLL+ L +
Sbjct: 607 ISNVPAEIQKEGPKA--MLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAP 664
Query: 1361 DLGMQSATVGIDVKDWPIQIRDKRKRDLV----LNVWDFAGREEFYSTHPHFMTQRALYL 1416
+ AT I W +Q R R V NVWD G + + F T +ALY+
Sbjct: 665 QVVHGEAT--IRTTKWELQ-RPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYV 721
Query: 1417 AVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELL-- 1474
V++L+ G+ V ++ WL NI+A+A ++ V++VGTHLD+ + K R ++ + +L
Sbjct: 722 VVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLAL 781
Query: 1475 -------NKRGFPAIRDYHFVNATEES-DALAKLRKTIINESLNFK-----IRDQLVVGQ 1521
GFP I H + +S + LR+ I + + + K I Q + G+
Sbjct: 782 CRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGR 841
Query: 1522 LIPDCYVELEKIILSE--RKNVPIEFPVIDRKRLLQLVRE---NQLQLDENELPHAVHFL 1576
LIP Y+ L++ +L+E R++ + + ++L QLV + N ++ D +L A+ FL
Sbjct: 842 LIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIK-DYEDLQSAISFL 900
Query: 1577 NESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLS 1636
E+G LLHF D + L +LYF++P WL + + +I +K G K + R + + L
Sbjct: 901 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIK--GSRSVAKNGVIRAEDLRMLL 958
Query: 1637 KKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCEN--SEIIIRL 1694
F + QYF+ L KF+IALP+ + L+P L +P ++ + + I R+
Sbjct: 959 VGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTHGMRHPTANTIQRV 1017
Query: 1695 YEMPYFPMGFWSRLINRLL----------------------EISPYMLSGRER------- 1725
++M + P+GFW R I R+L +++ Y +G +R
Sbjct: 1018 FKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFR 1077
Query: 1726 ALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESF-LKITVPSCRKGCILLGQVVDHI 1784
R +YW++G+ + + + S+V +S +KI S + + + DH+
Sbjct: 1078 VKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHV 1137
Query: 1785 DSLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDGEEHQKILLDDLMK 1832
+SL+++WFP L + +G L+++ WA ++ E+ Q ++D +
Sbjct: 1138 NSLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVL 1195
Query: 1833 KAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGS 1892
A E D + P P L +P+ ++ P+L + D P + L N +LE + +LG G G+
Sbjct: 1196 TAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGT 1255
Query: 1893 V-YRAAYEGEEVAVKIFN-----------KHTSLRLLR------------QELVVLCHLH 1928
V YRA Y+G+ VAVK F+ T LR LR QE +L L
Sbjct: 1256 VIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQ 1315
Query: 1929 HPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLR 1983
HP +++L+ I P +ELA SL+ +L ++ L L +IA +A GL
Sbjct: 1316 HPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLA 1375
Query: 1984 YLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEV 2043
YLH II+ DLK N+L+++L I K++DYGI++ G EGTPG++APE+
Sbjct: 1376 YLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI 1435
Query: 2044 ARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP 2103
R ++Y+++ D++S+G++LY++L +G R G +L+I KL ++ P
Sbjct: 1436 -RPRIVYDEKVDMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQP 1487
Query: 2104 ----WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATH 2159
+ ++ L+ +C P++RP + V + + K ++
Sbjct: 1488 EEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQ 1544
Query: 2160 HNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIV 2216
W G ++ +NTE E R+ C + L V++ W
Sbjct: 1545 GQEYTVVFWDG----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW-- 1595
Query: 2217 SGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 2275
+ T+ + + + +T ++ D+ + C K+ ++L L G ADG +A+F
Sbjct: 1596 TATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 1655
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 127 bits (319), Expect = 1e-28
Identities = 181/731 (24%), Positives = 304/731 (41%), Gaps = 119/731 (16%)
Query: 956 DDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEK 1015
D +LR+ KL+S++R ++ A +L+ A S + + +L +E
Sbjct: 17 DAALRARKLRSNLRQLTLTAAGACPGAGADALESPA---------SPQLVLPANLGDIEA 67
Query: 1016 LELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSC-IANLDVSRNDIGPSV 1074
L L N L P+ L L SL L L N+F P + ++ + LDVS N + ++
Sbjct: 68 LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRL-TAL 126
Query: 1075 VLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKI 1133
+ L++ NLS+NQL +P L + LE+L + N+++ + L L L+
Sbjct: 127 GAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLPDSLSCLSRLRT 185
Query: 1134 LNLSKNHISSLSENFLE--ACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEA 1191
L++ N +++ L+ A +++ S R+ L ++ IL LS + +P
Sbjct: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
Query: 1192 ILNLPHLRSLDMSSNDIQYLPGP----AHWKSLNLRELLFSHNQISILDLSEKAYLWSRV 1247
L L SL + +N +Q LP K LNL LF ++L L+ +
Sbjct: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAG-------L 298
Query: 1248 EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFD 1307
E+L+LS N+L +P I L L +L + N +R P+ + +L+ + +L L +
Sbjct: 299 EELYLSRNQLTSVPSLISGLGRLLTLWLDNN-RIRYLPDSIVELTGLEELVLQGNQIAVL 357
Query: 1308 FKHIG-------CKAKD--IIRFLQQRLKKAVPY----------------NRMKLMIVGN 1342
H G K KD +I+ + K +PY R+KL+++G+
Sbjct: 358 PDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGH 417
Query: 1343 TGSGKTTLLQQLM------------KTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVL 1390
+GKT L L K K + GI+V W R L
Sbjct: 418 KAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADA----SRGLRF 473
Query: 1391 NVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAE--VDAMKPWLFNIKARASSSPVI 1448
V+D AG E + P F++ ALY+ V +L+ + + +L + AR + V
Sbjct: 474 IVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVC 533
Query: 1449 LVGTHLDVSDEKQRKACMSKITKELLNKRGFPA--------------IRDYHFVNATEE- 1493
+VGTH D+ E++ + I +++ + A RD+ +A+
Sbjct: 534 IVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHA 593
Query: 1494 -----SDALAKLRKTIINESLNFKIR---DQLVVGQLIPDCYVELEKIILSERKNVPIEF 1545
SD + RK LN +++ L V P L +LS ++ I F
Sbjct: 594 AYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRHLRRLRDKLLSVAEHREI-F 652
Query: 1546 PVIDR--KRLLQLVRENQLQ----------------------LDENELPHAVHFLNESGV 1581
P + R R Q++ E Q L E+ L A+ +L+ESG
Sbjct: 653 PNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGK 712
Query: 1582 LLHFQD-PALQ 1591
LL+F+D PAL+
Sbjct: 713 LLYFEDSPALK 723
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 109 bits (272), Expect = 4e-23
Identities = 90/280 (32%), Positives = 145/280 (51%), Gaps = 27/280 (9%)
Query: 1874 ELEF-EQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNK------HTSLRLLRQELVVLCH 1926
E++F E E ++G G FG VYRA + G+EVAVK ++ +RQE +
Sbjct: 138 EIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 197
Query: 1927 LHHPSLISLLAAGIR-PRM-LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRY 1984
L HP++I+L ++ P + LVME A G L+R+L + + + A+ +A G+ Y
Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNY 255
Query: 1985 LHS---AMIIYRDLKPHNVLLFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGF 2038
LH II+RDLK N+L+ N + I KI D+G+A+ R ++ GT +
Sbjct: 256 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAW 315
Query: 2039 RAPEVARGNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPDPV 2096
APEV R + ++++ +DV+S+G+LL+++LT R ++GL KL P+
Sbjct: 316 MAPEVIRAS-MFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGV----AMNKLALPI 370
Query: 2097 KEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAE 2136
P P KL++ C +P RP+ + D L + E
Sbjct: 371 P--STCPEPFA-KLMEDCWNPDPHSRPSFTNILDQLTTIE 407
>gi|21735566 mitogen-activated protein kinase kinase kinase 7 isoform
D [Homo sapiens]
Length = 491
Score = 107 bits (267), Expect = 1e-22
Identities = 81/281 (28%), Positives = 145/281 (51%), Gaps = 38/281 (13%)
Query: 1869 MLNNDELEFEQAP-EFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHL 1927
+LN +E+++++ E ++G G+FG V +A + ++VA+K + + EL L +
Sbjct: 25 VLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 1928 HHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYL 1985
+HP+++ L A + P LVME A GSL +L + T H ++ L + G+ YL
Sbjct: 85 NHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 144
Query: 1986 HSAM---IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAP 2041
HS +I+RDLKP N+LL + KI D+G A C + + ++G+ + AP
Sbjct: 145 HSMQPKALIHRDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAP 198
Query: 2042 EVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGK 2091
EV G+ Y+++ DV+S+G++L++++T FDE+ G
Sbjct: 199 EVFEGS-NYSEKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGT 247
Query: 2092 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDIL 2132
P +K P P +E L+ +C ++P +RP+ ++ I+
Sbjct: 248 RPPLIKN---LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|21735564 mitogen-activated protein kinase kinase kinase 7 isoform
C [Homo sapiens]
Length = 518
Score = 107 bits (267), Expect = 1e-22
Identities = 81/281 (28%), Positives = 145/281 (51%), Gaps = 38/281 (13%)
Query: 1869 MLNNDELEFEQAP-EFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHL 1927
+LN +E+++++ E ++G G+FG V +A + ++VA+K + + EL L +
Sbjct: 25 VLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 1928 HHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYL 1985
+HP+++ L A + P LVME A GSL +L + T H ++ L + G+ YL
Sbjct: 85 NHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 144
Query: 1986 HSAM---IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAP 2041
HS +I+RDLKP N+LL + KI D+G A C + + ++G+ + AP
Sbjct: 145 HSMQPKALIHRDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAP 198
Query: 2042 EVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGK 2091
EV G+ Y+++ DV+S+G++L++++T FDE+ G
Sbjct: 199 EVFEGS-NYSEKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGT 247
Query: 2092 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDIL 2132
P +K P P +E L+ +C ++P +RP+ ++ I+
Sbjct: 248 RPPLIKN---LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|21735562 mitogen-activated protein kinase kinase kinase 7 isoform
B [Homo sapiens]
Length = 606
Score = 107 bits (267), Expect = 1e-22
Identities = 81/281 (28%), Positives = 145/281 (51%), Gaps = 38/281 (13%)
Query: 1869 MLNNDELEFEQAP-EFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHL 1927
+LN +E+++++ E ++G G+FG V +A + ++VA+K + + EL L +
Sbjct: 25 VLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 1928 HHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYL 1985
+HP+++ L A + P LVME A GSL +L + T H ++ L + G+ YL
Sbjct: 85 NHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 144
Query: 1986 HSAM---IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAP 2041
HS +I+RDLKP N+LL + KI D+G A C + + ++G+ + AP
Sbjct: 145 HSMQPKALIHRDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAP 198
Query: 2042 EVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGK 2091
EV G+ Y+++ DV+S+G++L++++T FDE+ G
Sbjct: 199 EVFEGS-NYSEKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGT 247
Query: 2092 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDIL 2132
P +K P P +E L+ +C ++P +RP+ ++ I+
Sbjct: 248 RPPLIKN---LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform A
[Homo sapiens]
Length = 579
Score = 107 bits (267), Expect = 1e-22
Identities = 81/281 (28%), Positives = 145/281 (51%), Gaps = 38/281 (13%)
Query: 1869 MLNNDELEFEQAP-EFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHL 1927
+LN +E+++++ E ++G G+FG V +A + ++VA+K + + EL L +
Sbjct: 25 VLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRV 84
Query: 1928 HHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIA--LHVADGLRYL 1985
+HP+++ L A + P LVME A GSL +L + T H ++ L + G+ YL
Sbjct: 85 NHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 144
Query: 1986 HSAM---IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CRMGIKTSEGTPGFRAP 2041
HS +I+RDLKP N+LL + KI D+G A C + + ++G+ + AP
Sbjct: 145 HSMQPKALIHRDLKPPNLLLVA----GGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAP 198
Query: 2042 EVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDEL----------EIQGK 2091
EV G+ Y+++ DV+S+G++L++++T FDE+ G
Sbjct: 199 EVFEGS-NYSEKCDVFSWGIILWEVITR----------RKPFDEIGGPAFRIMWAVHNGT 247
Query: 2092 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDIL 2132
P +K P P +E L+ +C ++P +RP+ ++ I+
Sbjct: 248 RPPLIKN---LPKP-IESLMTRCWSKDPSQRPSMEEIVKIM 284
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 106 bits (265), Expect = 3e-22
Identities = 109/437 (24%), Positives = 188/437 (43%), Gaps = 46/437 (10%)
Query: 934 NSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANE 993
NSL + D D LK+ R + + LR ++ S + DS+++L IT+++
Sbjct: 156 NSLTSLPDSLDNLKKLRMLDLRHNKLR--EIPSVVYRLDSLTTLYLRFNRITTVEKDIKN 213
Query: 994 LRDIDALS-------QKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNK 1046
L + LS Q L +L L++ N L P+++ + +T+LDL N+
Sbjct: 214 LSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQHNE 272
Query: 1047 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVV 1106
P + +S ++ L + N + S + KC L++ NL N +S +PE+L +
Sbjct: 273 LLDLPDTIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330
Query: 1107 EKLEQLILEGN--KISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF 1164
KL L L N ++ + P + + LN+ N I+ + + + + N
Sbjct: 331 VKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQ 390
Query: 1165 LAAMPF--------------------LPP------SMTILKLSQNKFSCIPEAILNLPHL 1198
L ++P +P S+ +L LS N +P + NL L
Sbjct: 391 LTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL 450
Query: 1199 RSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLK 1258
R LD+ N ++ LP + +L++L+ ++NQ++ L + + L L N L
Sbjct: 451 RELDLEENKLESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHL--TNLTHLGLGENLLT 507
Query: 1259 EIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDI 1318
+P EIG LENL L ++ N L S P E+ SK+ + ++ L+ I
Sbjct: 508 HLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPS- 566
Query: 1319 IRFLQQRLKKAVPYNRM 1335
F+ Q LK PY M
Sbjct: 567 --FIIQFLKMQGPYRAM 581
Score = 88.2 bits (217), Expect = 9e-17
Identities = 108/390 (27%), Positives = 167/390 (42%), Gaps = 64/390 (16%)
Query: 961 SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQ 1020
S +L R + S E +T L L +N+L+ + A + C L +L L L +
Sbjct: 102 SMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPA--EVGC----LVNLMTLALSE 155
Query: 1021 NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRN------------ 1068
N+LTS P L + LK L LDL NK PS + ++ + L + N
Sbjct: 156 NSLTSLPDSL-DNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNL 214
Query: 1069 ------------------DIGP---SVVLD-----------PTVKCPTLKQFNLSYNQLS 1096
+IG + LD C + +L +N+L
Sbjct: 215 SKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELL 274
Query: 1097 FVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKV 1155
+P+ + + + L +L L N++S I L + L+ LNL N+IS+L E+ L + K+
Sbjct: 275 DLPDTIGN-LSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKL 333
Query: 1156 ESFSARMNFLAAMPFLPPSM--TI--LKLSQNKFSCIPEAILNLPH-LRSLDMSSNDIQY 1210
S + N P PS TI L + N+ + IP I + L L+M N +
Sbjct: 334 NSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTS 393
Query: 1211 LP-GPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLEN 1269
LP W S + EL + NQ++ + E +E L LS+N LK++P +G L
Sbjct: 394 LPLDFGTWTS--MVELNLATNQLT--KIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 1270 LTSLDVSYNLELRSFPNEMGKLSKIWDLPL 1299
L LD+ N +L S PNE+ L + L L
Sbjct: 450 LRELDLEEN-KLESLPNEIAYLKDLQKLVL 478
Score = 72.0 bits (175), Expect = 7e-12
Identities = 91/366 (24%), Positives = 162/366 (44%), Gaps = 83/366 (22%)
Query: 1011 EHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANL-DVSRND 1069
E+ +L+L + ++ P + E L LT L L+SNK S P+ ++ C+ NL ++ ++
Sbjct: 100 ENSMRLDLSKRSIHILPSSIKE-LTQLTELYLYSNKLQSLPA---EVGCLVNLMTLALSE 155
Query: 1070 IGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-L 1128
+ + D L+ +L +N+L +P ++ ++ L L L N+I+ + ++ L
Sbjct: 156 NSLTSLPDSLDNLKKLRMLDLRHNKLREIP-SVVYRLDSLTTLYLRFNRITTVEKDIKNL 214
Query: 1129 KELKILNLSKNHISSL---------------SENFLEACPK------------------- 1154
+L +L++ +N I L + N LE PK
Sbjct: 215 SKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELL 274
Query: 1155 -----------VESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCIPEAIL-NLPHLR 1199
+ R N L+A+P ++ L L N S +PE++L +L L
Sbjct: 275 DLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLN 334
Query: 1200 SLDMSSNDIQYLP--GPAHWK---SLN-------------------LRELLFSHNQISIL 1235
SL ++ N Q P GP+ + SLN L +L NQ++ L
Sbjct: 335 SLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL 394
Query: 1236 DLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIW 1295
L W+ + +L+L+ N+L +IP ++ L +L L +S NL L+ P+ +G L K+
Sbjct: 395 PLDFGT--WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNL-LKKLPHGLGNLRKLR 451
Query: 1296 DLPLDE 1301
+L L+E
Sbjct: 452 ELDLEE 457
Score = 71.6 bits (174), Expect = 9e-12
Identities = 53/173 (30%), Positives = 91/173 (52%), Gaps = 6/173 (3%)
Query: 1134 LNLSKNHISSLSENFLEACPKVESF--SARMNFLAAMPFLPPSMTILKLSQNKFSCIPEA 1191
L+LSK I L + E E + S ++ L A ++ L LS+N + +P++
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 1192 ILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLH 1251
+ NL LR LD+ N ++ +P ++ +L L N+I+ ++ K S++ L
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVV-YRLDSLTTLYLRFNRITTVEKDIKNL--SKLSMLS 221
Query: 1252 LSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHL 1304
+ NK+K++P EIG L NL +LDV++N +L P E+G ++I +L L L
Sbjct: 222 IRENKIKQLPAEIGELCNLITLDVAHN-QLEHLPKEIGNCTQITNLDLQHNEL 273
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 104 bits (260), Expect = 1e-21
Identities = 97/308 (31%), Positives = 149/308 (48%), Gaps = 40/308 (12%)
Query: 1851 PISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIF-- 1908
P + +AP A P + L + E E ++G G FG VYRA + GEEVAVK
Sbjct: 72 PSNYVAPGAPAA--PAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARL 129
Query: 1909 ----NKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRP--RMLVMELASKGSLDRLLQQD 1962
+ + + QE + L HP++I+L A + P LVME A G+L R+L
Sbjct: 130 DPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL--- 186
Query: 1963 KASLTRTLQHRI---ALHVADGLRYLHS---AMIIYRDLKPHNVLLFTLYPN---AAIIA 2013
+ R H + A+ VA G+ YLH+ II+RDLK N+L+ N A +
Sbjct: 187 --AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVL 244
Query: 2014 KIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRI 2073
KI D+G+A+ + ++ GT + APEV R + ++++ +DV+SFG+LL+++LT
Sbjct: 245 KITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS-LFSKSSDVWSFGVLLWELLT----- 298
Query: 2074 VEGLKFPNEFDELEI-----QGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQV 2128
G E D L + KL P+ P P +L+++C +P RP +
Sbjct: 299 --GEVPYREIDALAVAYGVAMNKLTLPIP--STCPEPFA-RLLEECWDPDPHGRPDFGSI 353
Query: 2129 FDILNSAE 2136
L E
Sbjct: 354 LKRLEVIE 361
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [Homo
sapiens]
Length = 466
Score = 104 bits (259), Expect = 1e-21
Identities = 72/241 (29%), Positives = 127/241 (52%), Gaps = 14/241 (5%)
Query: 1885 LGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRM 1944
+G+G FG+V + Y G++VAVK + + E V+ + H +L+ LL + +
Sbjct: 200 IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGL 259
Query: 1945 -LVMELASKGSLDRLLQQDKASLTRTLQ-HRIALHVADGLRYLHSAMIIYRDLKPHNVLL 2002
+VME SKG+L L+ +L T Q + +LHVA+G+ YL S +++RDL N+L+
Sbjct: 260 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV 319
Query: 2003 FTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 2062
+ ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+L
Sbjct: 320 -----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVL 372
Query: 2063 LYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER 2122
L+++ + G + + +E ++ P GC P P V L+ C + P R
Sbjct: 373 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARR 427
Query: 2123 P 2123
P
Sbjct: 428 P 428
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [Homo
sapiens]
Length = 508
Score = 104 bits (259), Expect = 1e-21
Identities = 72/241 (29%), Positives = 127/241 (52%), Gaps = 14/241 (5%)
Query: 1885 LGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRM 1944
+G+G FG+V + Y G++VAVK + + E V+ + H +L+ LL + +
Sbjct: 242 IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGL 301
Query: 1945 -LVMELASKGSLDRLLQQDKASLTRTLQ-HRIALHVADGLRYLHSAMIIYRDLKPHNVLL 2002
+VME SKG+L L+ +L T Q + +LHVA+G+ YL S +++RDL N+L+
Sbjct: 302 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV 361
Query: 2003 FTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 2062
+ ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+L
Sbjct: 362 -----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVL 414
Query: 2063 LYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER 2122
L+++ + G + + +E ++ P GC P P V L+ C + P R
Sbjct: 415 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARR 469
Query: 2123 P 2123
P
Sbjct: 470 P 470
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [Homo
sapiens]
Length = 507
Score = 104 bits (259), Expect = 1e-21
Identities = 72/241 (29%), Positives = 127/241 (52%), Gaps = 14/241 (5%)
Query: 1885 LGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRM 1944
+G+G FG+V + Y G++VAVK + + E V+ + H +L+ LL + +
Sbjct: 241 IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGL 300
Query: 1945 -LVMELASKGSLDRLLQQDKASLTRTLQ-HRIALHVADGLRYLHSAMIIYRDLKPHNVLL 2002
+VME SKG+L L+ +L T Q + +LHVA+G+ YL S +++RDL N+L+
Sbjct: 301 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV 360
Query: 2003 FTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLL 2062
+ ++AK++D+G+A+ R G+ +S + APE + + ++DV+SFG+L
Sbjct: 361 -----SEDLVAKVSDFGLAK-AERKGLDSSRLPVKWTAPEALKHGK-FTSKSDVWSFGVL 413
Query: 2063 LYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER 2122
L+++ + G + + +E ++ P GC P P V L+ C + P R
Sbjct: 414 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP---EGC-PGP-VHVLMSSCWEAEPARR 468
Query: 2123 P 2123
P
Sbjct: 469 P 469
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 101 bits (252), Expect = 8e-21
Identities = 85/287 (29%), Positives = 146/287 (50%), Gaps = 37/287 (12%)
Query: 1884 LLGDGSFGSVYRAAYEGEEVAVKIFNKH------TSLRLLRQELVVLCHLHHPSLISLLA 1937
L+G G FG VYRA ++G+EVAVK + + +R+E + L HP++I L
Sbjct: 129 LIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRG 188
Query: 1938 AGI-RPRM-LVMELASKGSLDRLLQQDKAS----------LTRTLQHRI---ALHVADGL 1982
+ +P + LV+E A G+L+R L A+ R H + A+ +A G+
Sbjct: 189 VCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGM 248
Query: 1983 RYLHS---AMIIYRDLKPHNVLLFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTP 2036
YLH I++RDLK N+LL + I KI D+G+A+ R ++ GT
Sbjct: 249 LYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTY 308
Query: 2037 GFRAPEVARGNVIYNQQADVYSFGLLLYDILT--TGGRIVEGLKFPNEFDELEIQGKLPD 2094
+ APEV + + ++++ +D++S+G+LL+++LT R ++GL ++ +P
Sbjct: 309 AWMAPEVIKSS-LFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIP- 366
Query: 2095 PVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLT 2141
P P KL+K+C +++P RP+ A + + L + E +T
Sbjct: 367 -----STCPEPFA-KLMKECWQQDPHIRPSFALILEQLTAIEGAVMT 407
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 100 bits (248), Expect = 2e-20
Identities = 71/220 (32%), Positives = 111/220 (50%), Gaps = 16/220 (7%)
Query: 1859 LILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHT-----S 1913
L+ A LP + L E+EF + ++G GSFG VY+ + VA+K + +T
Sbjct: 447 LLRAGLPSHFHLQLSEIEFHE----IIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD 502
Query: 1914 LRLLRQELVVLCHLHHPSLISLLAAGIRPRM---LVMELASKGSLDRLLQQDKASLTRTL 1970
+ + +E+ +LC L+HP +I + A + +V + S GSL LL + K L
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 562
Query: 1971 QHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG 2028
+ IA+ VA G+ YLH+ II+RDL HN+LL+ A++A + Q
Sbjct: 563 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYE--DGHAVVADFGESRFLQSLDEDN 620
Query: 2029 IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT 2068
+ G + APEV Y +ADV+S+ L L++ILT
Sbjct: 621 MTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT 660
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 100 bits (248), Expect = 2e-20
Identities = 71/220 (32%), Positives = 111/220 (50%), Gaps = 16/220 (7%)
Query: 1859 LILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHT-----S 1913
L+ A LP + L E+EF + ++G GSFG VY+ + VA+K + +T
Sbjct: 548 LLRAGLPSHFHLQLSEIEFHE----IIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSD 603
Query: 1914 LRLLRQELVVLCHLHHPSLISLLAAGIRPRM---LVMELASKGSLDRLLQQDKASLTRTL 1970
+ + +E+ +LC L+HP +I + A + +V + S GSL LL + K L
Sbjct: 604 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQS 663
Query: 1971 QHRIALHVADGLRYLHSAM--IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMG 2028
+ IA+ VA G+ YLH+ II+RDL HN+LL+ A++A + Q
Sbjct: 664 KLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYE--DGHAVVADFGESRFLQSLDEDN 721
Query: 2029 IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT 2068
+ G + APEV Y +ADV+S+ L L++ILT
Sbjct: 722 MTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT 761
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 97.8 bits (242), Expect = 1e-19
Identities = 76/236 (32%), Positives = 116/236 (49%), Gaps = 27/236 (11%)
Query: 1881 PEFLLGDGSFGSVYRAAYE--GEEVAVKIFNKHTSLRL-------LRQELVVLCHLHHPS 1931
P+ +LG G FG VY + G +VA+KI +K LR LR E+ +L +LHHP
Sbjct: 585 PDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDK---LRFPTKQESQLRNEVAILQNLHHPG 641
Query: 1932 LISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM 1989
+++L P +VME L+ +L +K L + + + LR+LH
Sbjct: 642 VVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKN 701
Query: 1990 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNV 2048
I++ DLKP NVLL + P + K+ D+G A+ + S GTP + APEV R N
Sbjct: 702 IVHCDLKPENVLLASADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLR-NK 758
Query: 2049 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPW 2104
YN+ D++S G+++Y L+ FP DE +I ++ + Y PW
Sbjct: 759 GYNRSLDMWSVGVIIYVSLSG--------TFPFNEDE-DIHDQIQNAAFMYPPNPW 805
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 96.3 bits (238), Expect = 3e-19
Identities = 82/305 (26%), Positives = 140/305 (45%), Gaps = 46/305 (15%)
Query: 1863 DLPRNIMLNNDELE--------FEQAPEFLLGDGSFGSVYRAAYE--GEEVAVKIFNKHT 1912
DL +I ++N +++ ++ + +LG G FG VY + G +VA+K+ +K
Sbjct: 552 DLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMR 611
Query: 1913 ----SLRLLRQELVVLCHLHHPSLISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASL 1966
LR E+ +L +LHHP +++L P +VME L+ +L +K+ L
Sbjct: 612 FPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRL 671
Query: 1967 TRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCR 2026
+ + + LR LH I++ DLKP NVLL + P + K+ D+G A+
Sbjct: 672 PERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQV--KLCDFGFARIIGE 729
Query: 2027 MGIKTS-EGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDE 2085
+ S GTP + APEV R YN+ D++S G+++Y L+ FP DE
Sbjct: 730 KSFRRSVVGTPAYLAPEVLRSKG-YNRSLDMWSVGVIIYVSLSG--------TFPFNEDE 780
Query: 2086 LEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRIL 2145
+I ++ + Y PW R S + D++N+ V + +R
Sbjct: 781 -DINDQIQNAAFMYPPNPW-----------------REISGEAIDLINNLLQVKMRKRYS 822
Query: 2146 LPKNV 2150
+ K++
Sbjct: 823 VDKSL 827
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 95.9 bits (237), Expect = 4e-19
Identities = 82/282 (29%), Positives = 130/282 (46%), Gaps = 44/282 (15%)
Query: 1881 PEFLLGDGSFGSVYRAAYE--GEEVAVKIFNKHTSLRL-------LRQELVVLCHLHHPS 1931
P+ +LG G FG VY + G +VAVK+ +K LR LR E+ +L L HP
Sbjct: 396 PDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDK---LRFPTKQESQLRNEVAILQSLRHPG 452
Query: 1932 LISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM 1989
+++L P +VME L+ +L +K L L + + LR+LH
Sbjct: 453 IVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKN 512
Query: 1990 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNV 2048
I++ DLKP NVLL + P + K+ D+G A+ + S GTP + APEV N
Sbjct: 513 IVHCDLKPENVLLASADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQ 569
Query: 2049 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 2108
YN+ D++S G+++Y L+ FP DE +I ++ + Y +PW +
Sbjct: 570 GYNRSLDMWSVGVIMYVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI- 619
Query: 2109 KLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNV 2150
SA D++N+ V + +R + K++
Sbjct: 620 ----------------SAGAIDLINNLLQVKMRKRYSVDKSL 645
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 95.9 bits (237), Expect = 4e-19
Identities = 82/282 (29%), Positives = 130/282 (46%), Gaps = 44/282 (15%)
Query: 1881 PEFLLGDGSFGSVYRAAYE--GEEVAVKIFNKHTSLRL-------LRQELVVLCHLHHPS 1931
P+ +LG G FG VY + G +VAVK+ +K LR LR E+ +L L HP
Sbjct: 553 PDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDK---LRFPTKQESQLRNEVAILQSLRHPG 609
Query: 1932 LISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM 1989
+++L P +VME L+ +L +K L L + + LR+LH
Sbjct: 610 IVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKN 669
Query: 1990 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNV 2048
I++ DLKP NVLL + P + K+ D+G A+ + S GTP + APEV N
Sbjct: 670 IVHCDLKPENVLLASADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQ 726
Query: 2049 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 2108
YN+ D++S G+++Y L+ FP DE +I ++ + Y +PW +
Sbjct: 727 GYNRSLDMWSVGVIMYVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI- 776
Query: 2109 KLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNV 2150
SA D++N+ V + +R + K++
Sbjct: 777 ----------------SAGAIDLINNLLQVKMRKRYSVDKSL 802
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 95.9 bits (237), Expect = 4e-19
Identities = 82/282 (29%), Positives = 130/282 (46%), Gaps = 44/282 (15%)
Query: 1881 PEFLLGDGSFGSVYRAAYE--GEEVAVKIFNKHTSLRL-------LRQELVVLCHLHHPS 1931
P+ +LG G FG VY + G +VAVK+ +K LR LR E+ +L L HP
Sbjct: 553 PDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDK---LRFPTKQESQLRNEVAILQSLRHPG 609
Query: 1932 LISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM 1989
+++L P +VME L+ +L +K L L + + LR+LH
Sbjct: 610 IVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKN 669
Query: 1990 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNV 2048
I++ DLKP NVLL + P + K+ D+G A+ + S GTP + APEV N
Sbjct: 670 IVHCDLKPENVLLASADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQ 726
Query: 2049 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 2108
YN+ D++S G+++Y L+ FP DE +I ++ + Y +PW +
Sbjct: 727 GYNRSLDMWSVGVIMYVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI- 776
Query: 2109 KLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNV 2150
SA D++N+ V + +R + K++
Sbjct: 777 ----------------SAGAIDLINNLLQVKMRKRYSVDKSL 802
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 95.9 bits (237), Expect = 4e-19
Identities = 82/282 (29%), Positives = 130/282 (46%), Gaps = 44/282 (15%)
Query: 1881 PEFLLGDGSFGSVYRAAYE--GEEVAVKIFNKHTSLRL-------LRQELVVLCHLHHPS 1931
P+ +LG G FG VY + G +VAVK+ +K LR LR E+ +L L HP
Sbjct: 553 PDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDK---LRFPTKQESQLRNEVAILQSLRHPG 609
Query: 1932 LISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAM 1989
+++L P +VME L+ +L +K L L + + LR+LH
Sbjct: 610 IVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKN 669
Query: 1990 IIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNV 2048
I++ DLKP NVLL + P + K+ D+G A+ + S GTP + APEV N
Sbjct: 670 IVHCDLKPENVLLASADPFPQV--KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLL-NQ 726
Query: 2049 IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVE 2108
YN+ D++S G+++Y L+ FP DE +I ++ + Y +PW +
Sbjct: 727 GYNRSLDMWSVGVIMYVSLSG--------TFPFNEDE-DINDQIQNAAFMYPASPWSHI- 776
Query: 2109 KLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNV 2150
SA D++N+ V + +R + K++
Sbjct: 777 ----------------SAGAIDLINNLLQVKMRKRYSVDKSL 802
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 95.1 bits (235), Expect = 8e-19
Identities = 89/291 (30%), Positives = 148/291 (50%), Gaps = 41/291 (14%)
Query: 1869 MLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGE----EVAVKIFNKHTSL---RLLRQEL 1921
+L+ ++++F+ ++G+G+FG V +A + + + A+K ++ S R EL
Sbjct: 818 VLDWNDIKFQD----VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGEL 873
Query: 1922 VVLCHL-HHPSLISLLAAGIRPRMLVM--ELASKGSL------DRLLQQDKA-----SLT 1967
VLC L HHP++I+LL A L + E A G+L R+L+ D A S
Sbjct: 874 EVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTA 933
Query: 1968 RTLQHRIALH----VADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQY 2023
TL + LH VA G+ YL I+RDL N+L+ Y +AKIAD+G+++
Sbjct: 934 STLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENY-----VAKIADFGLSRG 988
Query: 2024 CCRMGIKTSEGTPGFRAPEVARGNV-IYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNE 2082
+ +K + G R + N +Y +DV+S+G+LL++I++ GG G+
Sbjct: 989 Q-EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL 1047
Query: 2083 FDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILN 2133
+++L +L P+ C V L++QC +E P ERP+ AQ+ LN
Sbjct: 1048 YEKLPQGYRLEKPL---NCD--DEVYDLMRQCWREKPYERPSFAQILVSLN 1093
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 94.7 bits (234), Expect = 1e-18
Identities = 71/221 (32%), Positives = 118/221 (53%), Gaps = 17/221 (7%)
Query: 1853 SQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEE--VAVKIFNK 1910
+ + PD + R+ + + E+E E LG G+ VYR +G + A+K+ K
Sbjct: 26 ASLVPDYWIDGSNRDALSDFFEVESE------LGRGATSIVYRCKQKGTQKPYALKVLKK 79
Query: 1911 HTSLRLLRQELVVLCHLHHPSLISLLAAGIRPR--MLVMELASKGSL-DRLLQQDKASLT 1967
+++R E+ VL L HP++I L P LV+EL + G L DR++++ S
Sbjct: 80 TVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSER 139
Query: 1968 RTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYC-CR 2026
+ + + YLH I++RDLKP N+L T P+A + KIAD+G+++ +
Sbjct: 140 DAAD--AVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPL--KIADFGLSKIVEHQ 195
Query: 2027 MGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDIL 2067
+ +KT GTPG+ APE+ RG Y + D++S G++ Y +L
Sbjct: 196 VLMKTVCGTPGYCAPEILRG-CAYGPEVDMWSVGIITYILL 235
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 94.0 bits (232), Expect = 2e-18
Identities = 97/325 (29%), Positives = 147/325 (45%), Gaps = 16/325 (4%)
Query: 1013 LEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP 1072
LE+L L N L P+ L +L L L N+ P + + LDVSRNDI
Sbjct: 38 LEELLLDANQLRELPKPFFRLL-NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 1073 SVVLDPTVK-CPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKE 1130
+ ++K C L+ + S N LS +P+ T + L L L + + + L
Sbjct: 97 ---IPESIKFCKALEIADFSGNPLSRLPDGFTQL-RSLAHLALNDVSLQALPGDVGNLAN 152
Query: 1131 LKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLP---PSMTILKLSQNKFSC 1187
L L L +N + SL + L K+E N L +P P++ L L +N+ S
Sbjct: 153 LVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
Query: 1188 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRV 1247
+P + NL L LD+S N ++ LP L L +LL S N + L + ++
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQL 268
Query: 1248 EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFD 1307
L + N+L E+ IG ENL+ L ++ NL L + P +GKL+K+ +L +D HL
Sbjct: 269 SILKVDQNRLCEVTEAIGDCENLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 1308 FKHI-GCKAKDIIRFLQQRLKKAVP 1331
I GC A ++ RL P
Sbjct: 328 PPEIGGCVALSVLSLRDNRLAVLPP 352
Score = 81.3 bits (199), Expect = 1e-14
Identities = 94/333 (28%), Positives = 157/333 (47%), Gaps = 31/333 (9%)
Query: 1012 HLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 1071
H+E ++ +L + P+++ +SL L L +N+ P ++ + L +S N+I
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 1072 PSVVLDPTV-KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE 1130
L P V L + ++S N + +PE++ + LE GN +S + P +
Sbjct: 73 R---LPPEVANFMQLVELDVSRNDIPEIPESIK-FCKALEIADFSGNPLSRL--PDGFTQ 126
Query: 1131 LKIL-NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIP 1189
L+ L +L+ N +S L+A P + LA ++ L+L +N +P
Sbjct: 127 LRSLAHLALNDVS------LQALP------GDVGNLA-------NLVTLELRENLLKSLP 167
Query: 1190 EAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEK 1249
++ L L LD+ ND++ LP NLREL NQ+S L E L R+
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVC 224
Query: 1250 LHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFK 1309
L +S N+L+E+P E+G L LT L +S NL LR P+ +G+L ++ L +D+ L +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 1310 HIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGN 1342
IG L + L A+P + KL + N
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
Score = 64.7 bits (156), Expect = 1e-09
Identities = 80/307 (26%), Positives = 134/307 (43%), Gaps = 21/307 (6%)
Query: 984 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 1043
+ LD+S N++ +I + C + LE + N L+ P + L+SL HL L+
Sbjct: 84 LVELDVSRNDIPEIPESIKFC------KALEIADFSGNPLSRLPDGFTQ-LRSLAHLALN 136
Query: 1044 SNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSYNQLSFVPENL 1102
+ P + ++ + L++ N + L VK L+Q +L N L +P+ L
Sbjct: 137 DVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGGNDLEVLPDTL 193
Query: 1103 TDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSAR 1161
+ L +L L+ N++S + L L+ L L++S+N + L L +
Sbjct: 194 -GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGGLVLLTDLLLS 251
Query: 1162 MNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWK 1218
N L +P ++ILK+ QN+ + EAI + +L L ++ N + LP K
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLG-K 310
Query: 1219 SLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN 1278
L L N + L + V L L N+L +PPE+ L LDV+ N
Sbjct: 311 LTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 1279 LELRSFP 1285
L+S P
Sbjct: 369 -RLQSLP 374
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 94.0 bits (232), Expect = 2e-18
Identities = 97/325 (29%), Positives = 147/325 (45%), Gaps = 16/325 (4%)
Query: 1013 LEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGP 1072
LE+L L N L P+ L +L L L N+ P + + LDVSRNDI
Sbjct: 38 LEELLLDANQLRELPKPFFRLL-NLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 1073 SVVLDPTVK-CPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL-RLKE 1130
+ ++K C L+ + S N LS +P+ T + L L L + + + L
Sbjct: 97 ---IPESIKFCKALEIADFSGNPLSRLPDGFTQL-RSLAHLALNDVSLQALPGDVGNLAN 152
Query: 1131 LKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLP---PSMTILKLSQNKFSC 1187
L L L +N + SL + L K+E N L +P P++ L L +N+ S
Sbjct: 153 LVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSA 211
Query: 1188 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRV 1247
+P + NL L LD+S N ++ LP L L +LL S N + L + ++
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVL-LTDLLLSQNLLR--RLPDGIGQLKQL 268
Query: 1248 EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFD 1307
L + N+L E+ IG ENL+ L ++ NL L + P +GKL+K+ +L +D HL
Sbjct: 269 SILKVDQNRLCEVTEAIGDCENLSELILTENL-LMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 1308 FKHI-GCKAKDIIRFLQQRLKKAVP 1331
I GC A ++ RL P
Sbjct: 328 PPEIGGCVALSVLSLRDNRLAVLPP 352
Score = 81.3 bits (199), Expect = 1e-14
Identities = 94/333 (28%), Positives = 157/333 (47%), Gaps = 31/333 (9%)
Query: 1012 HLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIG 1071
H+E ++ +L + P+++ +SL L L +N+ P ++ + L +S N+I
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 1072 PSVVLDPTV-KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKE 1130
L P V L + ++S N + +PE++ + LE GN +S + P +
Sbjct: 73 R---LPPEVANFMQLVELDVSRNDIPEIPESIK-FCKALEIADFSGNPLSRL--PDGFTQ 126
Query: 1131 LKIL-NLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIP 1189
L+ L +L+ N +S L+A P + LA ++ L+L +N +P
Sbjct: 127 LRSLAHLALNDVS------LQALP------GDVGNLA-------NLVTLELRENLLKSLP 167
Query: 1190 EAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEK 1249
++ L L LD+ ND++ LP NLREL NQ+S L E L R+
Sbjct: 168 ASLSFLVKLEQLDLGGNDLEVLPDTLGALP-NLRELWLDRNQLSALP-PELGNL-RRLVC 224
Query: 1250 LHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFK 1309
L +S N+L+E+P E+G L LT L +S NL LR P+ +G+L ++ L +D+ L +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNL-LRRLPDGIGQLKQLSILKVDQNRLCEVTE 283
Query: 1310 HIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGN 1342
IG L + L A+P + KL + N
Sbjct: 284 AIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
Score = 64.7 bits (156), Expect = 1e-09
Identities = 80/307 (26%), Positives = 134/307 (43%), Gaps = 21/307 (6%)
Query: 984 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 1043
+ LD+S N++ +I + C + LE + N L+ P + L+SL HL L+
Sbjct: 84 LVELDVSRNDIPEIPESIKFC------KALEIADFSGNPLSRLPDGFTQ-LRSLAHLALN 136
Query: 1044 SNKFTSFPSYLLKMSCIANLDVSRNDIGP-SVVLDPTVKCPTLKQFNLSYNQLSFVPENL 1102
+ P + ++ + L++ N + L VK L+Q +L N L +P+ L
Sbjct: 137 DVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK---LEQLDLGGNDLEVLPDTL 193
Query: 1103 TDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSAR 1161
+ L +L L+ N++S + L L+ L L++S+N + L L +
Sbjct: 194 -GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAE-LGGLVLLTDLLLS 251
Query: 1162 MNFLAAMPF---LPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWK 1218
N L +P ++ILK+ QN+ + EAI + +L L ++ N + LP K
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLG-K 310
Query: 1219 SLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYN 1278
L L N + L + V L L N+L +PPE+ L LDV+ N
Sbjct: 311 LTKLTNLNVDRNHLEALPPEIGGCVALSV--LSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Query: 1279 LELRSFP 1285
L+S P
Sbjct: 369 -RLQSLP 374
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 93.6 bits (231), Expect = 2e-18
Identities = 102/379 (26%), Positives = 182/379 (48%), Gaps = 28/379 (7%)
Query: 939 IFDHEDL--LKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRD 996
+F +DL L K+ L + SL +++ + ++ + SL ++ L+ +
Sbjct: 144 LFYSQDLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPT 203
Query: 997 IDALSQKC--------CISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFT 1048
+ L+ C + V + +L+ L N L S P +L E +K L++L L N+FT
Sbjct: 204 LAELNVSCNALRSVPAAVGV-MHNLQTFLLDGNFLQSLPAEL-ENMKQLSYLGLSFNEFT 261
Query: 1049 SFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEK 1108
P L K++ + L +S N + ++ L K P +K +L N + + + D ++
Sbjct: 262 DIPEVLEKLTAVDKLCMSGNCV-ETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQH 320
Query: 1109 LEQLILEGNKISGICSPLRLKELKILNLSKNHISSLS--ENFLEACPKVESFSARMNFLA 1166
+ QL L NK+ G + +++L+ +N + +L FL+A + + S + L
Sbjct: 321 VTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKA---LYASSNELVQLD 376
Query: 1167 AMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELL 1226
P +P ++ + +S+N+ +PE + L LD+ N I LP S +LR+LL
Sbjct: 377 VYP-VPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS-SLRKLL 434
Query: 1227 FSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGC-LENLTSLDVSYNLELRSFP 1285
HNQ++ L E+ S VE L + HN+L E+PP + ++L L+ S N +L S P
Sbjct: 435 AGHNQLA--RLPERLERTS-VEVLDVQHNQLLELPPNLLMKADSLRFLNASAN-KLESLP 490
Query: 1286 NEMGKLSKIWDLPLDELHL 1304
LS+ + L EL+L
Sbjct: 491 --PATLSEETNSILQELYL 507
Score = 57.8 bits (138), Expect = 1e-07
Identities = 62/203 (30%), Positives = 93/203 (45%), Gaps = 23/203 (11%)
Query: 922 LQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASER 981
L R L+R S + + H LL+ +L DSLR ++ S ++L+ E
Sbjct: 440 LARLPERLERTSVEVLDV-QHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEET 498
Query: 982 EYITS-LDLSANELRDIDALSQKCC--ISVHLEHLEKLELHQNALTSFPQQLCETLKSLT 1038
I L L+ N L D KC ++ H HL+ L + N L SFP L+ L
Sbjct: 499 NSILQELYLTNNSLTD------KCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELE 551
Query: 1039 HLDLHSNKFTSFPSYLLKMSCIANLDVSRN--DIGPSVVLDPTVKCPTLKQFNLSYNQLS 1096
+DL NK + P+ ++ + + N ++ P V+ P +KC +LS N+LS
Sbjct: 552 EIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKC-----VDLSCNELS 606
Query: 1097 FV--PENLTDVVEKLEQLILEGN 1117
V PENL KL++L L GN
Sbjct: 607 EVTLPENLP---PKLQELDLTGN 626
Score = 54.3 bits (129), Expect = 1e-06
Identities = 63/238 (26%), Positives = 97/238 (40%), Gaps = 31/238 (13%)
Query: 1013 LEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKM---SCIANLDVSRND 1069
+E L++ N L P L SL L+ +NK S P L S + L ++ N
Sbjct: 452 VEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLTNNS 511
Query: 1070 IGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLK 1129
+ V T P LK +++YN+L P + +E+LE++ L GNK+ I
Sbjct: 512 LTDKCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAI------- 563
Query: 1130 ELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS--C 1187
I+N + H N +E P+V P + + LS N+ S
Sbjct: 564 PTTIMNCRRMHTVIAHSNCIEVFPEVMQL--------------PEIKCVDLSCNELSEVT 609
Query: 1188 IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWS 1245
+PE + P L+ LD++ N L N+R F +Q S D S +WS
Sbjct: 610 LPENL--PPKLQELDLTGNPRLVLDHKTLELLNNIR--CFKIDQPSTGDASGAPAVWS 663
Score = 45.4 bits (106), Expect = 7e-04
Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 50/245 (20%)
Query: 1047 FTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF--NLSYNQLSFVPENLTD 1104
FT + +L ++S +A+ +S D+ C +L+ NL Y+Q +LT
Sbjct: 109 FTEYLRWLRQVSKVASQRISSVDLS----------CCSLEHLPANLFYSQ------DLTH 152
Query: 1105 VVEKLEQLILEGNK----ISGICSPLRLKELKILNLSKNHIS---------------SLS 1145
+ L+Q L N G+ R +LK LNLS NH+ ++S
Sbjct: 153 L--NLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVS 210
Query: 1146 ENFLEACP-------KVESFSARMNFLAAMPFLPPSM---TILKLSQNKFSCIPEAILNL 1195
N L + P +++F NFL ++P +M + L LS N+F+ IPE + L
Sbjct: 211 CNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEKL 270
Query: 1196 PHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 1255
+ L MS N ++ L A K +++ + N I L E +L V +L L N
Sbjct: 271 TAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFL-QHVTQLDLRDN 329
Query: 1256 KLKEI 1260
KL ++
Sbjct: 330 KLGDL 334
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 93.2 bits (230), Expect = 3e-18
Identities = 84/272 (30%), Positives = 137/272 (50%), Gaps = 28/272 (10%)
Query: 1882 EFLLGDGSFGSVYRAAYEGEEVAVKIFNK------HTSLRLLRQELVVLCHLHHPSLISL 1935
E ++G G FG VYR ++ GE VAVK + + +RQE + L HP++I+L
Sbjct: 120 EEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIAL 179
Query: 1936 LAAGI-RPRM-LVMELASKGSLDRLLQQDKASLTRTLQHRI---ALHVADGLRYLHS--- 1987
A + P + LVME A+ G L R L + R H + A+ +A G+ YLH
Sbjct: 180 KAVCLEEPNLCLVMEYAAGGPLSRAL-----AGRRVPPHVLVNWAVQIARGMHYLHCEAL 234
Query: 1988 AMIIYRDLKPHNVLLFTLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 2044
+I+RDLK +N+LL + + KI D+G+A+ + ++ GT + APEV
Sbjct: 235 VPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVI 294
Query: 2045 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPW 2104
+ + +++ +DV+SFG+LL+++L TG G+ + + KL P+ P
Sbjct: 295 KAST-FSKGSDVWSFGVLLWELL-TGEVPYRGIDCLAVAYGVAV-NKLTLPIP--STCPE 349
Query: 2105 PMVEKLIKQCLKENPQERPTSAQVFDILNSAE 2136
P + L+ C ++P RP A + L + E
Sbjct: 350 PFAQ-LMADCWAQDPHRRPDFASILQQLEALE 380
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 92.0 bits (227), Expect = 6e-18
Identities = 95/359 (26%), Positives = 160/359 (44%), Gaps = 18/359 (5%)
Query: 977 LASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKS 1036
L E E +T+LD S L + I + LE+L L N + P+QL +S
Sbjct: 17 LRGEEETVTTLDYSHCSLEQVPKE-----IFTFEKTLEELYLDANQIEELPKQLFNC-QS 70
Query: 1037 LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLS 1096
L L L N T+ P+ + + + LDVS+N G + C L S N +S
Sbjct: 71 LHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNPIS 128
Query: 1097 FVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKV 1155
+P+ + ++ L QL L + + + RL +L+IL L +N + L + + ++
Sbjct: 129 KLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLTQL 186
Query: 1156 ESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 1212
E N +P + ++ LK + N+ + IP I +L L LD+S N+I+ +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 1213 GPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTS 1272
NL++LL S N S+ L E + L + N+L +P IG L ++
Sbjct: 247 EGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 1273 LDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1331
LD S+N E+ + P+ +G+L+ + D +L IG + FL + +P
Sbjct: 304 LDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Score = 89.0 bits (219), Expect = 5e-17
Identities = 90/358 (25%), Positives = 156/358 (43%), Gaps = 59/358 (16%)
Query: 984 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 1043
+ L L AN++ ++ C + L KL L N LT+ P + + +L LD+
Sbjct: 48 LEELYLDANQIEELPKQLFNC------QSLHKLSLPDNDLTTLPASIANLI-NLRELDVS 100
Query: 1044 SNKFTSFPSYLLKMSCIANLDVSRNDI-----GPSVVLDPTV----------------KC 1082
N FP + + ++ S N I G S +L+ T +
Sbjct: 101 KNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRL 160
Query: 1083 PTLKQFNLSYNQLSFVPENL----------------TDVVEKLEQLI------LEGNKIS 1120
L+ L NQL +P+ + T+V E LEQL ++ N+++
Sbjct: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT 220
Query: 1121 GICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---T 1176
I + LK+L L++SKN+I + E + C ++ N L +P S+ T
Sbjct: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 1177 ILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILD 1236
LK+ +N+ +P++I L + LD S N+++ LP + + NLR HN +
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--Q 336
Query: 1237 LSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1294
L + W + L L NKL+ +P E+G ++ L +++S N L++ P KL ++
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 92.0 bits (227), Expect = 6e-18
Identities = 95/359 (26%), Positives = 160/359 (44%), Gaps = 18/359 (5%)
Query: 977 LASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKS 1036
L E E +T+LD S L + I + LE+L L N + P+QL +S
Sbjct: 17 LRGEEETVTTLDYSHCSLEQVPKE-----IFTFEKTLEELYLDANQIEELPKQLFNC-QS 70
Query: 1037 LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLS 1096
L L L N T+ P+ + + + LDVS+N G + C L S N +S
Sbjct: 71 LHKLSLPDNDLTTLPASIANLINLRELDVSKN--GIQEFPENIKNCKVLTIVEASVNPIS 128
Query: 1097 FVPENLTDVVEKLEQLILEGNKISGICSPL-RLKELKILNLSKNHISSLSENFLEACPKV 1155
+P+ + ++ L QL L + + + RL +L+IL L +N + L + + ++
Sbjct: 129 KLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT-MNRLTQL 186
Query: 1156 ESFSARMNFLAAMPFLPPSMTILK---LSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLP 1212
E N +P + ++ LK + N+ + IP I +L L LD+S N+I+ +
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 1213 GPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTS 1272
NL++LL S N S+ L E + L + N+L +P IG L ++
Sbjct: 247 EGIS-TCENLQDLLLSSN--SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 1273 LDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVP 1331
LD S+N E+ + P+ +G+L+ + D +L IG + FL + +P
Sbjct: 304 LDCSFN-EVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Score = 89.0 bits (219), Expect = 5e-17
Identities = 90/358 (25%), Positives = 156/358 (43%), Gaps = 59/358 (16%)
Query: 984 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLH 1043
+ L L AN++ ++ C + L KL L N LT+ P + + +L LD+
Sbjct: 48 LEELYLDANQIEELPKQLFNC------QSLHKLSLPDNDLTTLPASIANLI-NLRELDVS 100
Query: 1044 SNKFTSFPSYLLKMSCIANLDVSRNDI-----GPSVVLDPTV----------------KC 1082
N FP + + ++ S N I G S +L+ T +
Sbjct: 101 KNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRL 160
Query: 1083 PTLKQFNLSYNQLSFVPENL----------------TDVVEKLEQLI------LEGNKIS 1120
L+ L NQL +P+ + T+V E LEQL ++ N+++
Sbjct: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT 220
Query: 1121 GICSPL-RLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSM---T 1176
I + LK+L L++SKN+I + E + C ++ N L +P S+ T
Sbjct: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEG-ISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 1177 ILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILD 1236
LK+ +N+ +P++I L + LD S N+++ LP + + NLR HN +
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPS-SIGQLTNLRTFAADHNYLQ--Q 336
Query: 1237 LSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKI 1294
L + W + L L NKL+ +P E+G ++ L +++S N L++ P KL ++
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN-RLKNLPFSFTKLQQL 393
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,651,125
Number of Sequences: 37866
Number of extensions: 3965506
Number of successful extensions: 15287
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 429
Number of HSP's successfully gapped in prelim test: 778
Number of HSP's that attempted gapping in prelim test: 11466
Number of HSP's gapped (non-prelim): 2565
length of query: 2527
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2408
effective length of database: 13,741,464
effective search space: 33089445312
effective search space used: 33089445312
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.