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Search of human proteins with 170650694
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
(1192 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 2373 0.0
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 1533 0.0
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 820 0.0
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 817 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 801 0.0
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 466 e-131
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 461 e-129
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 460 e-129
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 459 e-129
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 458 e-128
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 457 e-128
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 441 e-123
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 441 e-123
gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens] 292 1e-78
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 189 2e-47
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 140 6e-33
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 129 2e-29
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 129 2e-29
gi|187608516 centaurin, beta 2 [Homo sapiens] 129 2e-29
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 128 3e-29
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 128 3e-29
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 128 3e-29
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 128 3e-29
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 128 3e-29
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 128 3e-29
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 123 1e-27
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 123 1e-27
gi|46094081 development and differentiation enhancing factor 1 [... 118 3e-26
gi|7661880 centaurin beta1 [Homo sapiens] 116 1e-25
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 110 1e-23
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 2373 bits (6149), Expect = 0.0
Identities = 1192/1192 (100%), Positives = 1192/1192 (100%)
Query: 1 MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEE 60
MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEE
Sbjct: 1 MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEE 60
Query: 61 PGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPG 120
PGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPG
Sbjct: 61 PGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPG 120
Query: 121 PPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKV 180
PPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKV
Sbjct: 121 PPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKV 180
Query: 181 APPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATA 240
APPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATA
Sbjct: 181 APPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATA 240
Query: 241 AAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPS 300
AAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPS
Sbjct: 241 AAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPS 300
Query: 301 PATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPP 360
PATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPP
Sbjct: 301 PATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPP 360
Query: 361 GSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKS 420
GSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKS
Sbjct: 361 GSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKS 420
Query: 421 SLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFS 480
SLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFS
Sbjct: 421 SLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFS 480
Query: 481 LEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMK 540
LEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMK
Sbjct: 481 LEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMK 540
Query: 541 RCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQAS 600
RCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQAS
Sbjct: 541 RCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQAS 600
Query: 601 NGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEK 660
NGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEK
Sbjct: 601 NGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEK 660
Query: 661 RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHS 720
RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHS
Sbjct: 661 RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHS 720
Query: 721 THGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSP 780
THGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSP
Sbjct: 721 THGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSP 780
Query: 781 SPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTT 840
SPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTT
Sbjct: 781 SPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTT 840
Query: 841 PSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDA 900
PSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDA
Sbjct: 841 PSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDA 900
Query: 901 WVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLN 960
WVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLN
Sbjct: 901 WVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLN 960
Query: 961 LGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAK 1020
LGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAK
Sbjct: 961 LGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAK 1020
Query: 1021 PSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHG 1080
PSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHG
Sbjct: 1021 PSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHG 1080
Query: 1081 PLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCA 1140
PLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCA
Sbjct: 1081 PLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCA 1140
Query: 1141 DILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV 1192
DILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV
Sbjct: 1141 DILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV 1192
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 1533 bits (3969), Expect = 0.0
Identities = 784/815 (96%), Positives = 789/815 (96%), Gaps = 20/815 (2%)
Query: 378 RELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKT 437
++ + A L + +AVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKT
Sbjct: 42 QDSIQASLDSIREAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKT 101
Query: 438 ESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQL 497
ESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQL
Sbjct: 102 ESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQL 161
Query: 498 SSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDR 557
SSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDR
Sbjct: 162 SSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDR 221
Query: 558 VFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPN 617
VFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPN
Sbjct: 222 VFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPN 281
Query: 618 VGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIP 677
VGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIP
Sbjct: 282 VGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIP 341
Query: 678 IKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPG 737
IKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPG
Sbjct: 342 IKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPG 401
Query: 738 KRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLL 797
KRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLL
Sbjct: 402 KRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLL 461
Query: 798 KPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKM 857
KPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAE
Sbjct: 462 KPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAE----- 516
Query: 858 WKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE 917
EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE
Sbjct: 517 ---------------EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE 561
Query: 918 SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG 977
SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG
Sbjct: 562 SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG 621
Query: 978 THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK 1037
THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK
Sbjct: 622 THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK 681
Query: 1038 YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL 1097
YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL
Sbjct: 682 YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL 741
Query: 1098 AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT 1157
AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT
Sbjct: 742 AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT 801
Query: 1158 TPSAATTPSITATPSPRRRSSAASVGRADAPVALV 1192
TPSAATTPSITATPSPRRRSSAASVGRADAPVALV
Sbjct: 802 TPSAATTPSITATPSPRRRSSAASVGRADAPVALV 836
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 820 bits (2117), Expect = 0.0
Identities = 445/806 (55%), Positives = 557/806 (69%), Gaps = 59/806 (7%)
Query: 391 AVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDG 450
A +NSQEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDG
Sbjct: 56 AFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDG 115
Query: 451 QTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLAL 510
Q++L+LIR+E G P+A+F+ W DAVIFVFSLEDE SFQ V + ++++ R + L
Sbjct: 116 QSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSE--IPL 173
Query: 511 ALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLR 570
LVGTQD IS+++PRV+ DARAR L D+KRC+YYETCATYGLNV+RVFQ+VAQK+V R
Sbjct: 174 VLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATR 233
Query: 571 KQQQL-LAACKSLPSSPSHSAA-----STPVAGQASNGGHT-SDYSSSLPSSPNVGHREL 623
K+QQL + CKSLP+SPSHS+ S Q SNGG + SDYSSS+PS+P+ +EL
Sbjct: 234 KKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKEL 293
Query: 624 RAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQS 681
R + A TP + + +KRR++LF +R+GSD EK+ L+SR ++ GSGRAIPIKQ
Sbjct: 294 RIDVPPTANTPTP--VRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQG 351
Query: 682 FLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPP 741
LLKRSG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKRPP
Sbjct: 352 MLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPP 411
Query: 742 RAISAFGPSAS--INGLVKDMSTV---------------QMGEGLEATTPMPSP------ 778
RA SA P +S NGL KDMS++ QM G+ + P
Sbjct: 412 RATSACAPISSPKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQR 471
Query: 779 SPSPSSLQPPPDQT--SKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMV--KKQR 834
S S SS + T + + D L ++ + + S SP +PPPSP KK R
Sbjct: 472 SYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSP-KLDPPPSPHANRKKHR 530
Query: 835 RKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAAS 894
RKK T+ K +G +G AE + EENFEF+IVS TGQTWHFEA +
Sbjct: 531 RKKSTSNFKADGLSGTAEEQ------------------EENFEFIIVSLTGQTWHFEATT 572
Query: 895 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 954
+EERDAWVQAIESQILASLQ CESSK K R SQSEA+A+Q+IRN +GNS CVDC NP
Sbjct: 573 YEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNP 632
Query: 955 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 1014
WASLNLGAL+CIECSGIHRNLGTHLSRVRSLDLDDWP EL V+++IGN+ AN VWE
Sbjct: 633 NWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEES 692
Query: 1015 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 1074
++GR KPS DS+REE+E WIRAKYEQ LFLAPL +E LG+ L A +D+ T +LLL
Sbjct: 693 SQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLL 752
Query: 1075 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 1134
AH ++ + + R+ LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 753 AHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQA 812
Query: 1135 GSQLCADILLQHGCPGEGGSAATTPS 1160
SQ C D+LLQ+GCP E TP+
Sbjct: 813 SSQECIDVLLQYGCPDERFVLMATPN 838
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 817 bits (2111), Expect = 0.0
Identities = 439/783 (56%), Positives = 548/783 (69%), Gaps = 66/783 (8%)
Query: 391 AVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDG 450
A +NSQEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDG
Sbjct: 56 AFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDG 115
Query: 451 QTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLAL 510
Q++L+LIR+E G P+A+F+ W DAVIFVFSLEDE SFQ V + ++++ R + L
Sbjct: 116 QSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSE--IPL 173
Query: 511 ALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLR 570
LVGTQD IS+++PRV+ DARAR L D+KRC+YYETCATYGLNV+RVFQ+VAQK+V R
Sbjct: 174 VLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATR 233
Query: 571 KQQQL-LAACKSLPSSPSHSAA-----STPVAGQASNGGHT-SDYSSSLPSSPNVGHREL 623
K+QQL + CKSLP+SPSHS+ S Q SNGG + SDYSSS+PS+P+ +EL
Sbjct: 234 KKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKEL 293
Query: 624 RAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQS 681
R + A TP + + +KRR++LF +R+GSD EK+ L+SR ++ GSGRAIPIKQ
Sbjct: 294 RIDVPPTANTPTP--VRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQG 351
Query: 682 FLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPP 741
LLKRSG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKRPP
Sbjct: 352 MLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPP 411
Query: 742 RAISAFGPSAS--INGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKP 799
RA SA P +S NGL KDMS++ + SP+S
Sbjct: 412 RATSACAPISSPKTNGLSKDMSSLHI---------------SPNS--------------- 441
Query: 800 DRNLARALSTDCTPSGDLSPLSREPPPSPMV--KKQRRKKLTTPSKTEGSAGQAEAKRKM 857
D L ++ + + S SP +PPPSP KK RRKK T+ K +G +G AE +
Sbjct: 442 DTGLGDSVCSSPSISSTTSP-KLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQ--- 497
Query: 858 WKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCE 917
EENFEF+IVS TGQTWHFEA ++EERDAWVQAIESQILASLQ CE
Sbjct: 498 ---------------EENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCE 542
Query: 918 SSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLG 977
SSK K R SQSEA+A+Q+IRN +GNS CVDC NP WASLNLGAL+CIECSGIHRNLG
Sbjct: 543 SSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLG 602
Query: 978 THLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAK 1037
THLSRVRSLDLDDWP EL V+++IGN+ AN VWE ++GR KPS DS+REE+E WIRAK
Sbjct: 603 THLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAK 662
Query: 1038 YEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHL 1097
YEQ LFLAPL +E LG+ L A +D+ T +LLLAH ++ + + R+ LHL
Sbjct: 663 YEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHL 722
Query: 1098 AAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAAT 1157
A +VV+ QLL+WYG DV ARDA G TAL YARQA SQ C D+LLQ+GCP E
Sbjct: 723 ACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMA 782
Query: 1158 TPS 1160
TP+
Sbjct: 783 TPN 785
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 801 bits (2069), Expect = 0.0
Identities = 436/817 (53%), Positives = 556/817 (68%), Gaps = 58/817 (7%)
Query: 393 INSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQT 452
+NSQEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ+
Sbjct: 114 VNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQS 173
Query: 453 HLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALAL 512
+L+LIR+E G P+ +F+ W DAV+FVFSLEDE SFQ V +L S R + + L
Sbjct: 174 YLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASE--VPMVL 231
Query: 513 VGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQ 572
VGTQD ISA++PRV+ D+RAR L D+KRC+YYETCATYGLNV+RVFQ+VAQKVV LRK+
Sbjct: 232 VGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKK 291
Query: 573 QQL-LAACKSLPSSPSHSA---ASTPVA--GQASNGGHT--SDYSSSLPSSPNVGHRELR 624
QQL + CKSLP+SPSHSA AS P QA+NGG + SDYSSS+PS+P++ RELR
Sbjct: 292 QQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELR 351
Query: 625 AEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSF 682
E +A STP + + +KRR+++F +R+G+D EK++ + + ++ GSGRAIPIKQ
Sbjct: 352 IET--IAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGI 409
Query: 683 LLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPR 742
LLKRSG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKR PR
Sbjct: 410 LLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPR 469
Query: 743 AISAFGPSAS--INGLVKDMSTVQMGEGLEA-----TTPMPSPSPSPSSLQPPPDQTSKH 795
A A P S NGL + S Q+G G A + + S P SS P H
Sbjct: 470 ATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLH 529
Query: 796 LLKPDRNLARALS--TDCTPSGDLSPLSR-----------EPPPSPMV--KKQRRKKLTT 840
+ A S T P G P S +PPPSP KK RRKK T
Sbjct: 530 QRSCSVSSADQWSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTG 589
Query: 841 PSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDA 900
+ +G + E +AEE+FEF++VS TGQTWHFEA++ EER+
Sbjct: 590 TPRPDGPSSATE------------------EAEESFEFVVVSLTGQTWHFEASTAEEREL 631
Query: 901 WVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLN 960
WVQ++++QILASLQ C S+K K R +Q+ A+A+QA+R +GNS C+DC APNP WASLN
Sbjct: 632 WVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLN 691
Query: 961 LGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAK 1020
LGAL+CIECSGIHR+LG HLSRVRSLDLDDWP EL V+TA+GN AN VWE G +K
Sbjct: 692 LGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSK 751
Query: 1021 PSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHG 1080
P D+ REE+E WIRAKYEQ LFLAPL +S+ PLG+QL AV D+ +++LLAH
Sbjct: 752 PGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKE 811
Query: 1081 PLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCA 1140
++ + D R+ LHL++ +A+VV TQLL+WYG DV +RDA+G T L YAR+AGSQ CA
Sbjct: 812 EVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECA 871
Query: 1141 DILLQHGCPGEGGSAATTPSA----ATTPSITATPSP 1173
DIL+QHGCPGEG A TP+ T PS SP
Sbjct: 872 DILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSP 908
Score = 35.4 bits (80), Expect = 0.33
Identities = 30/105 (28%), Positives = 38/105 (36%), Gaps = 4/105 (3%)
Query: 95 PAPASPARPVSPAPG---RRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLSSPSWG 151
P P + APG R L L GG A S RPL SS +W
Sbjct: 463 PGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPL-SSSAWA 521
Query: 152 GPEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTS 196
GP PEG SS+ + L PA P + +++S
Sbjct: 522 GPRPEGLHQRSCSVSSADQWSEATTSLPPGMQHPASGPAEVLSSS 566
Score = 32.0 bits (71), Expect = 3.6
Identities = 42/154 (27%), Positives = 55/154 (35%), Gaps = 22/154 (14%)
Query: 11 RTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEEPGKKRHERLF 70
RTT + L + P SP A + G G+P A
Sbjct: 457 RTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSAS-------L 509
Query: 71 HRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPGP--PLSGG-- 126
H + L SS+ G P L S VS A + ++PPG P SG
Sbjct: 510 HSERPL----SSSAWAGPRPEGLHQRSCS----VSSADQWSEATTSLPPGMQHPASGPAE 561
Query: 127 -LSPDPK--PGGAPTSSRRPLLSSPSWGGPEPEG 157
LS PK P +P S+R+ S G P P+G
Sbjct: 562 VLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDG 595
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 466 bits (1200), Expect = e-131
Identities = 265/570 (46%), Positives = 347/570 (60%), Gaps = 58/570 (10%)
Query: 587 SHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRR 646
S + ++ + + + GG ++YSSS+P +P+ +L A TP + + +
Sbjct: 32 SFAFSTVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTP--ICKQSMGW 89
Query: 647 TSLFANRRGSDSEK--RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSS 704
++LF + +GSD +K ++L+S +T GSGRAIPIKQ LLKRSG L K WKKKYVTL S
Sbjct: 90 SNLFTSEKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCS 148
Query: 705 NGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASINGLVKDMST 762
NG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ NGL KDM
Sbjct: 149 NGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEA 208
Query: 763 VQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSP-LS 821
+ M D L ++ + S SP L+
Sbjct: 209 LHMSAN------------------------------SDIGLGDSICFSPSISSTTSPKLN 238
Query: 822 REPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIV 881
P P KK +KK T K +G + AE EE +F+IV
Sbjct: 239 LPPSPHANKKKHLKKKSTNNLKDDGLSSTAE--------------------EEEEKFMIV 278
Query: 882 SSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAK 941
S TGQT HF+A ++EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +
Sbjct: 279 SVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMR 338
Query: 942 GNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTA 1001
GNS CVDC NP WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP EL V+++
Sbjct: 339 GNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSS 398
Query: 1002 IGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAA 1061
IGND AN +WE ++G+ KPS +S+REE+E WIR+KYE LFLAPL +E LG+ L A
Sbjct: 399 IGNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRA 458
Query: 1062 VQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARD 1121
+D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG DV ARD
Sbjct: 459 TADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARD 518
Query: 1122 AQGRTALFYARQAGSQLCADILLQHGCPGE 1151
A G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 519 AHGNTALTYARQASSQECINVLLQYGCPDE 548
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH domain
8 [Homo sapiens]
Length = 663
Score = 461 bits (1186), Expect = e-129
Identities = 265/577 (45%), Positives = 346/577 (59%), Gaps = 83/577 (14%)
Query: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 162 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
Query: 639 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
Query: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 279 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 338
Query: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
GL KDM T +G+ + SPS SS P
Sbjct: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
Query: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
PPPSP K++ K + +
Sbjct: 365 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 387
Query: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+
Sbjct: 388 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMAL 444
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Q+I+N +GN+ CVDC NP WASLNLG L+CIECSGIH +LGT LSRVRSL+LDDWP E
Sbjct: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVE 504
Query: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
L V+++IGND AN +WE ++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 505 LRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSL 564
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G+QL A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG
Sbjct: 565 GQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 624
Query: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 625 VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 460 bits (1184), Expect = e-129
Identities = 265/577 (45%), Positives = 346/577 (59%), Gaps = 83/577 (14%)
Query: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 639 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 361
Query: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
GL KDM T +G+ + SPS SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
Query: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
PPPSP K++ K + +
Sbjct: 388 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 410
Query: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+
Sbjct: 411 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMAL 467
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Q+I+N +GN+ CVDC NP WASLNLG L+CIECSGIHR+LG HLSRVRSL+LDDWP E
Sbjct: 468 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVE 527
Query: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
L V+++I ND AN +WE ++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 528 LRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSL 587
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G+QL A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG
Sbjct: 588 GQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 647
Query: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 648 VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH domain
4 [Homo sapiens]
Length = 663
Score = 459 bits (1182), Expect = e-129
Identities = 263/575 (45%), Positives = 346/575 (60%), Gaps = 83/575 (14%)
Query: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 162 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
Query: 639 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
Query: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P ++ N
Sbjct: 279 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSN 338
Query: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
GL KDM T +G+ + SPS SS P
Sbjct: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
Query: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
PPPSP K++ K + +
Sbjct: 365 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 387
Query: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K + SQS+A+A+
Sbjct: 388 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMAL 444
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Q+I+N +GN+ CVDC NP WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP E
Sbjct: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVE 504
Query: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
L V+++IGND AN +WE ++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 505 LRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSL 564
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G+QL A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG
Sbjct: 565 GQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 624
Query: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCP 1149
DV ARDA G TAL YARQA SQ C ++LLQ+GCP
Sbjct: 625 VDVMARDAHGNTALTYARQASSQECINVLLQYGCP 659
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH domain
7 [Homo sapiens]
Length = 663
Score = 458 bits (1178), Expect = e-128
Identities = 264/577 (45%), Positives = 344/577 (59%), Gaps = 83/577 (14%)
Query: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
S+P HS A + V + GG ++YSSS+PS+P+ + + A TP
Sbjct: 162 SIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
Query: 639 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
Query: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
KKYVTL SNG L Y+ S+ DY+ H KE+DL +T+KVPGK P A A P S+ +
Sbjct: 279 KKYVTLCSNGVLTYYSSLGDYMKYIHKKEIDLQTSTIKVPGKWPSLATLACTPISSSKSD 338
Query: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
GL KDM T +G+ + SPS SS P
Sbjct: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTIP-------------------------- 364
Query: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
PPPSP K++ K + +
Sbjct: 365 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 387
Query: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+
Sbjct: 388 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMAL 444
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Q+I+N +GN+ CVDC NP WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP E
Sbjct: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVE 504
Query: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
L V+++IGND AN +WE ++GR KP+ S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 505 LRKVMSSIGNDLANSIWEGSSQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLPCTELSL 564
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G+QL A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG
Sbjct: 565 GQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 624
Query: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 625 VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH domain
5 [Homo sapiens]
Length = 686
Score = 457 bits (1176), Expect = e-128
Identities = 264/577 (45%), Positives = 344/577 (59%), Gaps = 83/577 (14%)
Query: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
S+P HS A + V + GG ++YSSS+PS+P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 639 LHRAAKRRTSLFANRRGS--DSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
+ + + R ++LF + +GS D E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
Query: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
GL KDM T +G+ + SPS SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 387
Query: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
PPPSP K++ K + +
Sbjct: 388 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 410
Query: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+
Sbjct: 411 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMAL 467
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Q+I+N +GN+ CVD NP WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP E
Sbjct: 468 QSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVE 527
Query: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
L V+++IGND AN +WE ++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 528 LRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSL 587
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G+ L A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG
Sbjct: 588 GQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 647
Query: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 648 VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat and
PH domain 9 [Homo sapiens]
Length = 684
Score = 441 bits (1134), Expect = e-123
Identities = 259/577 (44%), Positives = 341/577 (59%), Gaps = 85/577 (14%)
Query: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
S+P HS A + V + + GG ++YSSS+P +P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 639 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
Query: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
GL KDM T +G+ + SP SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPGISSTTSP-------------------------- 387
Query: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
PPPSP K++ K + +
Sbjct: 388 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 410
Query: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ C+SSK K + SQSEA+A+
Sbjct: 411 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMAL 467
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Q+I+N +GN+ CVDC NP WASLNLG L+CIECSGIHR+ GT LSRVRSL+LDDWP E
Sbjct: 468 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVE 527
Query: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
L V+++IGN+ AN +WE ++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 528 LRKVMSSIGNELANSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSL 587
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G+QL A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL G
Sbjct: 588 GQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XG 645
Query: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 646 VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 682
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat and
PH domain 10 [Homo sapiens]
Length = 684
Score = 441 bits (1134), Expect = e-123
Identities = 259/577 (44%), Positives = 341/577 (59%), Gaps = 85/577 (14%)
Query: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
S+P HS A + V + + GG ++YSSS+P +P+ + + A TP
Sbjct: 185 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTPTP-- 242
Query: 639 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 243 VCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 301
Query: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 302 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSN 361
Query: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
GL KDM T +G+ + SP SS P
Sbjct: 362 GLSKDMDT-GLGDSI-------CFSPGISSTTSP-------------------------- 387
Query: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
PPPSP K++ K + +
Sbjct: 388 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 410
Query: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ C+SSK K + SQSEA+A+
Sbjct: 411 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMAL 467
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Q+I+N +GN+ CVDC NP WASLNLG L+CIECSGIHR+ GT LSRVRSL+LDDWP E
Sbjct: 468 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVE 527
Query: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
L V+++IGN+ AN +WE ++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 528 LRKVMSSIGNELANSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSL 587
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G+QL A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL G
Sbjct: 588 GQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XG 645
Query: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 646 VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 682
>gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens]
Length = 396
Score = 292 bits (748), Expect = 1e-78
Identities = 152/266 (57%), Positives = 202/266 (75%), Gaps = 12/266 (4%)
Query: 393 INSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQT 452
+NSQEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ+
Sbjct: 114 VNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQS 173
Query: 453 HLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALAL 512
+L+LIR+E G P+ +F+ W DAV+FVFSLEDE SFQ V +L S R + + L
Sbjct: 174 YLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASE--VPMVL 231
Query: 513 VGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQ 572
VGTQD ISA++PRV+ D+RAR L D+KRC+YYETCATYGLNV+RVFQ+VAQKVV LRK+
Sbjct: 232 VGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKK 291
Query: 573 QQL-LAACKSLPSSPSH---SAASTPVA--GQASNGGHT--SDYSSSLPSSPNVGHRELR 624
QQL + CKSLP+SPSH SAAS P QA+NGG + SDYSSS+PS+P++ RELR
Sbjct: 292 QQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELR 351
Query: 625 AEAAAVAGLSTPGSLHRAAKRRTSLF 650
E +A STP + + +KRR+++F
Sbjct: 352 IE--TIAASSTPTPIRKQSKRRSNIF 375
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 189 bits (479), Expect = 2e-47
Identities = 93/176 (52%), Positives = 123/176 (69%)
Query: 976 LGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIR 1035
L + SRVRSL+LDDWP EL V+++IGND AN +WE ++G+ KPS S+REE+E WIR
Sbjct: 107 LHSFASRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIR 166
Query: 1036 AKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPL 1095
+KYE+ LFLAPL ++ LG+QL A +D+ T +LLLAH ++ + + + L
Sbjct: 167 SKYEEKLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTAL 226
Query: 1096 HLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
HLA +VV+ QLL+WYG DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 227 HLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 282
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
[Homo sapiens]
Length = 834
Score = 140 bits (354), Expect = 6e-33
Identities = 79/203 (38%), Positives = 120/203 (59%), Gaps = 24/203 (11%)
Query: 873 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ----CCES---------- 918
E F F ++S T ++ +A S + R AWVQA+++ I ++ + C S
Sbjct: 327 ERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPS 385
Query: 919 -SKVKLRTDSQSEAV----AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIH 973
S + TD++ V +Q +++ GNS C DCG P+P WAS+NLG L+CIECSGIH
Sbjct: 386 TSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIH 445
Query: 974 RNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRA--KPSRDSSREERE 1031
R+LG H S+VRSL LD W EL ++ +GN N+++E+ G KP+ SSR+++E
Sbjct: 446 RSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKE 505
Query: 1032 SWIRAKYEQLLFL--APLSTSEE 1052
+WI+ KY + FL AP++ + E
Sbjct: 506 AWIKDKYVEKKFLRKAPMAPALE 528
Score = 36.6 bits (83), Expect = 0.15
Identities = 38/137 (27%), Positives = 61/137 (44%), Gaps = 20/137 (14%)
Query: 1010 VWESDTRGRAKPSRDSSRE-----ERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQA 1064
V +S T S +SS E E E+W A +L P G A +A
Sbjct: 630 VVDSVTEEEGAESEESSGEADGDTEAEAWGLADVREL----------HP-GLLAHRAARA 678
Query: 1065 QDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQG 1124
+D+ + LAH ++ + + + ++PL A +++ + LL GADV RD++G
Sbjct: 679 RDLPALAAALAHGAE--VNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRG 736
Query: 1125 RTALFYARQAG--SQLC 1139
R L +A G Q+C
Sbjct: 737 RAPLHHATLLGRTGQVC 753
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 129 bits (324), Expect = 2e-29
Identities = 95/296 (32%), Positives = 143/296 (48%), Gaps = 32/296 (10%)
Query: 886 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA-----------VAI 934
+T+HF+A E +AWV +++ +L + S A + I
Sbjct: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLD-DWPR 993
+++ GNS C DCGA +PTW S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
Query: 994 ELTLVLTAIGNDTANRVWESD--TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 1051
EL L L +GN + N V E+ + G KPS +S R +I AKY + F +
Sbjct: 481 ELLLALN-MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT--- 536
Query: 1052 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSP----LHLAAELAH---V 1104
P ++LW A+ +D+ +VL A+ + + P ++P LHLA ++A+ +
Sbjct: 537 -PEPQRLWTAICNRDLLSVLEAFANGQ--DFGQPLPGPDAQAPEELVLHLAVKVANQASL 593
Query: 1105 VITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH----GCPGEGGSAA 1156
+ ++ G + A+ A G TAL YA C +LL+ G E G A
Sbjct: 594 PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETA 649
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 129 bits (324), Expect = 2e-29
Identities = 95/296 (32%), Positives = 143/296 (48%), Gaps = 32/296 (10%)
Query: 886 QTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA-----------VAI 934
+T+HF+A E +AWV +++ +L + S A + I
Sbjct: 370 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 429
Query: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLD-DWPR 993
+++ GNS C DCGA +PTW S NLG L CI+CSG+HR LG SR++SL LD P
Sbjct: 430 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 489
Query: 994 ELTLVLTAIGNDTANRVWESD--TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 1051
EL L L +GN + N V E+ + G KPS +S R +I AKY + F +
Sbjct: 490 ELLLALN-MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT--- 545
Query: 1052 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSP----LHLAAELAH---V 1104
P ++LW A+ +D+ +VL A+ + + P ++P LHLA ++A+ +
Sbjct: 546 -PEPQRLWTAICNRDLLSVLEAFANGQ--DFGQPLPGPDAQAPEELVLHLAVKVANQASL 602
Query: 1105 VITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH----GCPGEGGSAA 1156
+ ++ G + A+ A G TAL YA C +LL+ G E G A
Sbjct: 603 PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETA 658
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 129 bits (324), Expect = 2e-29
Identities = 79/204 (38%), Positives = 119/204 (58%), Gaps = 21/204 (10%)
Query: 873 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ--CCESSKVKLRT----- 925
E F F +VS T ++ +A S + R AW++A+++ I + + ES K+ ++
Sbjct: 325 ERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTG 383
Query: 926 --DSQSEAV--------AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRN 975
DS +E+ A+Q ++ GN+ C DCG +P WAS+NLG +CIECSGIHR+
Sbjct: 384 SLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRS 443
Query: 976 LGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTR--GRAKPSRDSSREERESW 1033
LG H S+VRSL LD W EL ++ +GND NRV+E++ G KP + R+E+E++
Sbjct: 444 LGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAY 502
Query: 1034 IRAKYEQLLFLAPLSTSEEPLGRQ 1057
IRAKY + F+ S S P +Q
Sbjct: 503 IRAKYVERKFVDKYSISLSPPEQQ 526
Score = 33.1 bits (74), Expect = 1.6
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 7/96 (7%)
Query: 1048 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVIT 1107
+ SEE L AV + T LL + + + D Q R PLH A L H
Sbjct: 635 ANSEENKATPLIQAVLGGSLVTCEFLLQNGAN----VNQRDVQGRGPLHHATVLGHTGQV 690
Query: 1108 QLLLWYGADVAARDAQGRTALFYARQAGSQLCADIL 1143
L L GA+ A D +G+ L A +A + ADI+
Sbjct: 691 CLFLKRGANQHATDEEGKDPLSIAVEAAN---ADIV 723
Score = 31.6 bits (70), Expect = 4.7
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 4/87 (4%)
Query: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
G QL+ A +++ + LAH S E+ +PL A +V + LL G
Sbjct: 607 GLQLYRASYEKNLPKMAEALAHGADVNWANSEENKA--TPLIQAVLGGSLVTCEFLLQNG 664
Query: 1115 ADVAARDAQGRTALFYARQAG--SQLC 1139
A+V RD QGR L +A G Q+C
Sbjct: 665 ANVNQRDVQGRGPLHHATVLGHTGQVC 691
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 128 bits (322), Expect = 3e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 938 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 998 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 128 bits (322), Expect = 3e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 938 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 998 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 128 bits (322), Expect = 3e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 938 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 998 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 128 bits (322), Expect = 3e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 938 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 998 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 128 bits (322), Expect = 3e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 938 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 998 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 128 bits (322), Expect = 3e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 938 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 998 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
Query: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform 1
[Homo sapiens]
Length = 770
Score = 123 bits (308), Expect = 1e-27
Identities = 73/216 (33%), Positives = 115/216 (53%), Gaps = 19/216 (8%)
Query: 945 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 1004
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
Query: 1005 DTANRVWE---------SDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPL------ST 1049
+ AN +WE R +A P +D + +IRAKY+ L F+ L
Sbjct: 70 NGANSIWEHSLLDPAQVQSGRRKANP-QDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
Query: 1050 SEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQL 1109
+ + L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +L
Sbjct: 129 TAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAEL 185
Query: 1110 LLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
L+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 186 LVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform 2
[Homo sapiens]
Length = 761
Score = 123 bits (308), Expect = 1e-27
Identities = 73/216 (33%), Positives = 115/216 (53%), Gaps = 19/216 (8%)
Query: 945 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 1004
+C DC AP+P WAS++ G L+C EC +HR+LG H+S V+ L WP L ++ + +
Sbjct: 10 VCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLAS 69
Query: 1005 DTANRVWE---------SDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPL------ST 1049
+ AN +WE R +A P +D + +IRAKY+ L F+ L
Sbjct: 70 NGANSIWEHSLLDPAQVQSGRRKANP-QDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGV 128
Query: 1050 SEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQL 1109
+ + L +QL ++V+ ++ T L LL+ G + +PLH+AA+ + +L
Sbjct: 129 TAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGTTPLHVAAKAGQTLQAEL 185
Query: 1110 LLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
L+ YGAD + D GRT + YARQAG A+ L++
Sbjct: 186 LVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|46094081 development and differentiation enhancing factor 1 [Homo
sapiens]
Length = 1129
Score = 118 bits (296), Expect = 3e-26
Identities = 81/288 (28%), Positives = 141/288 (48%), Gaps = 22/288 (7%)
Query: 872 AEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCC---ESSKVKLRTDSQ 928
AE+ F ++S +T+HF+A ++ AW+ + + +L E S + +
Sbjct: 379 AEDKKSFDLISHN-RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDL 437
Query: 929 SEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDL 988
++A+ I+ ++ GN IC DCG+ PTW S NLG L CIECSGIHR +G H+SR++SL+L
Sbjct: 438 TKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLEL 496
Query: 989 DDWPRELTLVLTAIGNDTANRVWESDTRGRA-KPSRDSSREERESWIRAKYEQLLFLAPL 1047
D L+ +GN++ N + E++ + KP+ S R+ +I AKY F
Sbjct: 497 DKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKT 556
Query: 1048 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQL-------RSPLHLA-- 1098
++ +L A++++D+ ++ + A + +P L + LHLA
Sbjct: 557 CSTSSAKLNELLEAIKSRDLLALIQVYAEG------VELMEPLLEPGQELGETALHLAVR 610
Query: 1099 -AELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
A+ + + L+ ++ + A G T L Y C +LL+
Sbjct: 611 TADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
Score = 38.5 bits (88), Expect = 0.038
Identities = 54/213 (25%), Positives = 77/213 (36%), Gaps = 37/213 (17%)
Query: 136 APTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHP-----GTGSRRL-KVAPPPPAPKP 189
+PTS P +P P P AG G G S P +GS L K PPPP P
Sbjct: 782 SPTS---PTTEAP----PLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGH 834
Query: 190 CKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGST 249
+T++ + G + W ++G P ++ G S ++ S+
Sbjct: 835 KRTLSDPPSPLPHGPPNKGAVPWG-NDGGPSSSSKTTNKFEGLSQQSST---------SS 884
Query: 250 ASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHP---------GPPAGSPPPLTLPPTPS 300
A T+ G K++ RK +LD + + P PPP LPP P+
Sbjct: 885 AKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPT 944
Query: 301 PATAVTAASAQPPGPA-----PPITLEPPAPGL 328
PP P P + PP P L
Sbjct: 945 ELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQL 977
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 116 bits (291), Expect = 1e-25
Identities = 87/300 (29%), Positives = 131/300 (43%), Gaps = 48/300 (16%)
Query: 934 IQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPR 993
+ +++ GN+ C DC P P WAS+NLG +CI+CSGIHR+LG H S+VRSL LD W
Sbjct: 408 VAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEP 467
Query: 994 ELTLVLTAIGNDTANRVWESDTRGRA--KPSRDSSREERESWIRAKYEQLLFLAPL---- 1047
EL ++ +GN N+++E+ A KP SR+E+E+WI AKY + FL L
Sbjct: 468 ELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIR 527
Query: 1048 -------------------STSEEPLGRQLWAAVQAQDVATV---LLLLAHARHGPLDTS 1085
S P + ++D+ ++ LL + H P +
Sbjct: 528 GRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGHPPSLPT 587
Query: 1086 VEDPQLR--------------SPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYA 1131
+ D +PL A ++ + LL GA+V D+ GR L +A
Sbjct: 588 MADALAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHA 647
Query: 1132 RQAGSQLCADILLQHGC-----PGEGGSAAT-TPSAATTPSITATPSPRRRSSAASVGRA 1185
G A + L+ G EG T A +T + R + A+ G+A
Sbjct: 648 TILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREAEAAQGQA 707
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 110 bits (274), Expect = 1e-23
Identities = 80/275 (29%), Positives = 122/275 (44%), Gaps = 14/275 (5%)
Query: 883 STGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVA---IQAIRN 939
S +T+HF+A +E W+ +++ +L ++ + + I ++
Sbjct: 370 SHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQR 429
Query: 940 AKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVL 999
GN +C DCGAP+PTW S NLG L CIECSGIHR LG H SR++SL LD L+
Sbjct: 430 MTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLA 489
Query: 1000 TAIGNDTANRVWES--DTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQ 1057
IGN N + E KP+ S R+ +I AKY + +
Sbjct: 490 KNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHS 549
Query: 1058 LWAAVQAQDVATVLLLLAH----ARHGPLDTSVEDPQLRSPLHLA---AELAHVVITQLL 1110
L AV+ +D+ +L A PL E + + LHLA + + I L
Sbjct: 550 LCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDE--TALHLAVRSVDRTSLHIVDFL 607
Query: 1111 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
+ ++ + +G TAL Y + C +LL+
Sbjct: 608 VQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
Score = 38.1 bits (87), Expect = 0.050
Identities = 37/111 (33%), Positives = 42/111 (37%), Gaps = 18/111 (16%)
Query: 94 SPAPASPARPVSPAPGRRLSLWAVPPGPPLSGG---LSPDPKPGGAPTSSRRPLLSSPSW 150
SP PA PA P S + PP PP + G L+P P P A T S LS PS
Sbjct: 770 SPPPAQPAAP---------STTSAPPLPPRNVGKDPLTPTPPPPVAKTPSVMEALSQPS- 819
Query: 151 GGPEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAG 201
P P G + P P P RL P P +T G G
Sbjct: 820 -KPAPPGISQIRPP----PLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRG 865
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,798,176
Number of Sequences: 37866
Number of extensions: 3944291
Number of successful extensions: 60890
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 748
Number of HSP's successfully gapped in prelim test: 2496
Number of HSP's that attempted gapping in prelim test: 25273
Number of HSP's gapped (non-prelim): 24487
length of query: 1192
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1078
effective length of database: 13,930,794
effective search space: 15017395932
effective search space used: 15017395932
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.