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Search of human proteins with 170650674
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170650674 phosphodiesterase 6A [Homo sapiens]
(860 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170650674 phosphodiesterase 6A [Homo sapiens] 1751 0.0
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 1266 0.0
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 1263 0.0
gi|157364939 phosphodiesterase 6C [Homo sapiens] 1143 0.0
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 923 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 431 e-120
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 393 e-109
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 393 e-109
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 393 e-109
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 389 e-108
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 349 5e-96
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 334 2e-91
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 256 8e-68
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 256 8e-68
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 256 8e-68
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 238 1e-62
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 238 1e-62
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 150 6e-36
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 150 6e-36
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 150 6e-36
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 150 6e-36
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 148 2e-35
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 148 2e-35
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 142 1e-33
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 142 1e-33
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 142 1e-33
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 133 6e-31
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 133 6e-31
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 133 6e-31
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 133 6e-31
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 1751 bits (4534), Expect = 0.0
Identities = 860/860 (100%), Positives = 860/860 (100%)
Query: 1 MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI 60
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
Sbjct: 1 MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI 60
Query: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV 120
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
Sbjct: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV 120
Query: 121 LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS 180
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
Sbjct: 121 LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS 180
Query: 181 PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI 240
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
Sbjct: 181 PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI 240
Query: 241 LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP 300
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
Sbjct: 241 LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP 300
Query: 301 PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM 360
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
Sbjct: 301 PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM 360
Query: 361 NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM 420
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
Sbjct: 361 NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM 420
Query: 421 ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW 480
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
Sbjct: 421 ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW 480
Query: 481 ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE 540
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
Sbjct: 481 ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE 540
Query: 541 ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
Sbjct: 541 ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600
Query: 601 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH 660
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
Sbjct: 601 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH 660
Query: 661 MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD 720
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
Sbjct: 661 MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD 720
Query: 721 LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV 780
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
Sbjct: 721 LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV 780
Query: 781 CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN 840
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
Sbjct: 781 CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN 840
Query: 841 QPGGNPSPGGATTSKSCCIQ 860
QPGGNPSPGGATTSKSCCIQ
Sbjct: 841 QPGGNPSPGGATTSKSCCIQ 860
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 1266 bits (3277), Expect = 0.0
Identities = 617/859 (71%), Positives = 709/859 (82%), Gaps = 11/859 (1%)
Query: 4 VTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAK---EAAVDFSNYHSPSSMEESEI 60
++ E+ FLD N FA+QY+ KL + + A D + +EES
Sbjct: 3 LSEEQARSFLDQNPDFARQYFG----KKLSPENVAAACEDGCPPDCDSLRDLCQVEESTA 58
Query: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV 120
+ +L++D QE++ E+ +F V+++LC LLQADR SLFMYR RNG+AELATRLF+V D+V
Sbjct: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
Query: 121 LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS 180
LEDCLV PD EIVFPLD+G+VGHVA +KK+ NV + E HF F D LT+YKTKN+LA+
Sbjct: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
Query: 181 PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI 240
PIMNGKDVVA+IMAVNK++G FT DE++ LKYLNFA L +K+YHLSYLHNCETRRGQ+
Sbjct: 179 PIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQV 238
Query: 241 LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP 300
LLWS +KVFEELTDIERQFHKA YTVRA+LNC+RYSVGLLDMTK+KEFFDVW VLMGE
Sbjct: 239 LLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQ 298
Query: 301 PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM 360
PYSGPRTPDGREI FYKVIDYILHGKE+IKVIP P DHWAL SGLP+YVA++G ICNIM
Sbjct: 299 PYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIM 358
Query: 361 NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM 420
NA A++ F FQ+ LD+SGW+IKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE DE LM
Sbjct: 359 NASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLM 418
Query: 421 ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW 480
ESLTQFLGWSV+N DTY+ MNKLENRKDI QD+V YHVKCD +EIQ IL TR GKEP
Sbjct: 419 ESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA 478
Query: 481 ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE 540
+C+E+EL EIL+ ELP ++I +FHFSDL TEL+LVKCGIQMYYEL VV KF IPQE
Sbjct: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
Query: 541 ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600
LVRF++S+SKGYR+ITYHNWRHGFNV QTMF+LL+TGKLK Y+TDLEA AMVTA CHD
Sbjct: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
Query: 601 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH 660
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGK LL +E+LNI+QNLNRRQHEH IH
Sbjct: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
Query: 661 MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD 720
+MDIAIIATDLALYFKKR MFQKIVD+SK Y+ ++ W +Y+ LE TRKEIVMAMMMTACD
Sbjct: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
Query: 721 LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV 780
LSAITKPWEVQS+VALLVAAEFWEQGDLERTVL Q PIPMMDRNKA ELPKLQVGFIDFV
Sbjct: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
Query: 781 CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN 840
CTFVYKEFSRFHEEI PM D + NNRKEWKALADEY+AK+K EEK+++++ A
Sbjct: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTE 838
Query: 841 QPGGNPSPGGATTSKSCCI 859
G P+P S +CCI
Sbjct: 839 ICNGGPAP----KSSTCCI 853
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 1263 bits (3269), Expect = 0.0
Identities = 619/860 (71%), Positives = 712/860 (82%), Gaps = 14/860 (1%)
Query: 4 VTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAK---EAAVDFSNYHSPSSMEESEI 60
++ E+ FLD N FA+QY+ KL + + A D + +EES
Sbjct: 3 LSEEQARSFLDQNPDFARQYFG----KKLSPENVAAACEDGCPPDCDSLRDLCQVEESTA 58
Query: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV 120
+ +L++D QE++ E+ +F V+++LC LLQADR SLFMYR RNG+AELATRLF+V D+V
Sbjct: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
Query: 121 LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS 180
LEDCLV PD EIVFPLD+G+VGHVA +KK+ NV + E HF F D LT+YKTKN+LA+
Sbjct: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
Query: 181 PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI 240
PIMNGKDVVA+IMAVNK++G FT DE++ LKYLNFA L +K+YHLSYLHNCETRRGQ+
Sbjct: 179 PIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQV 238
Query: 241 LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP 300
LLWS +KVFEELTDIERQFHKA YTVRA+LNC+RYSVGLLDMTK+KEFFDVW VLMGE
Sbjct: 239 LLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQ 298
Query: 301 PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM 360
PYSGPRTPDGREI FYKVIDYILHGKE+IKVIP P DHWAL SGLP+YVA++G ICNIM
Sbjct: 299 PYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIM 358
Query: 361 NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM 420
NA A++ F FQ+ LD+SGW+IKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE DE LM
Sbjct: 359 NASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLM 418
Query: 421 ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW 480
ESLTQFLGWSV+N DTY+ MNKLENRKDI QD+V YHVKCD +EIQ IL TR GKEP
Sbjct: 419 ESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA 478
Query: 481 ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE 540
+C+E+EL EIL+ ELP ++I +FHFSDL TEL+LVKCGIQMYYEL VV KF IPQE
Sbjct: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
Query: 541 ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600
LVRF++S+SKGYR+ITYHNWRHGFNV QTMF+LL+TGKLK Y+TDLEA AMVTA CHD
Sbjct: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
Query: 601 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH 660
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGK LL +E+LNI+QNLNRRQHEH IH
Sbjct: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
Query: 661 MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD 720
+MDIAIIATDLALYFKKR MFQKIVD+SK Y+ ++ W +Y+ LE TRKEIVMAMMMTACD
Sbjct: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
Query: 721 LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV 780
LSAITKPWEVQS+VALLVAAEFWEQGDLERTVL Q PIPMMDRNKA ELPKLQVGFIDFV
Sbjct: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
Query: 781 CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN 840
CTFVYKEFSRFHEEI PM D + NNRKEWKALADEY+AK+K EEK+++++ A A G
Sbjct: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVA--AKKGT 836
Query: 841 Q-PGGNPSPGGATTSKSCCI 859
+ G P+P S +CCI
Sbjct: 837 EICNGGPAP----KSSTCCI 852
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 1143 bits (2956), Expect = 0.0
Identities = 548/860 (63%), Positives = 695/860 (80%), Gaps = 8/860 (0%)
Query: 1 MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFS-NYHSPSSMEESE 59
MGE+ VEK+L+ N FAK+Y++ R +++ ++ + V S ++ + +EES
Sbjct: 1 MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA 60
Query: 60 IIFDLLRDFQENLQT-EKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKD 118
+ +LL QE T E+ + +++L LLQADR S+F+ R+RNGI E+A+RL +V
Sbjct: 61 LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT 120
Query: 119 AVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNIL 178
+ ED LV PD+E+VFPLD+GIVG AH+KK NVP+ +++ HF DF+D T Y TKN+L
Sbjct: 121 SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL 180
Query: 179 ASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRG 238
A+PI+ GK+V+A+IMAVNKV+ S F+K+DEE+ KYLNF ++I++++H SY++N E+RR
Sbjct: 181 ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS 240
Query: 239 QILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGE 298
QIL+WS +KVFEELTD+ERQFHKALYTVR++LNC+RYS+GLLDMTK+KEF+D WP+ +GE
Sbjct: 241 QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE 300
Query: 299 VPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICN 358
V PY GP+TPDGRE+NFYK+IDYILHGKE+IKVIP PP DHW L+SGLP YVA+NG ICN
Sbjct: 301 VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN 360
Query: 359 IMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDET 418
+MNAPA+++F FQK P+DE+GW+IKNVLS+PIVNKKE+IVGVATFYNRKDGKPFDE DE
Sbjct: 361 MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY 420
Query: 419 LMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKE 478
+ E+LTQFLGWS+LN DTY+ MNKLENRKDI Q+++ K EEI+ ILK +E +
Sbjct: 421 ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD 480
Query: 479 PW-ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHI 537
+CEE++L IL+ +LPD E+ +F FSD PLTE L+KCGI++++E+ VV+KF +
Sbjct: 481 VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV 540
Query: 538 PQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAF 597
P E L R+MY++ KGYR +TYHNWRHGFNVGQTMF+LL+TG+LK+Y+TDLEA AM+ AAF
Sbjct: 541 PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF 600
Query: 598 CHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEH 657
CHDIDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ KTLL+DESLNIFQNLN+RQ E
Sbjct: 601 CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET 660
Query: 658 AIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMT 717
IH+ ++AIIATDLALYFKKRTMFQKIVD + ++E+E +Y+ ++ T+KEI+MAMMMT
Sbjct: 661 VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT 720
Query: 718 ACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFI 777
ACDLSAITKPWEVQSQVAL+VA EFWEQGDLERTVLQQ PIPMMDRNK DELPKLQVGFI
Sbjct: 721 ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI 780
Query: 778 DFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAA 837
DFVCTFVYKEFSRFH+EITPML G+ NNR EWK+LADEYDAKMKV EE+ +KQ+ A
Sbjct: 781 DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA 840
Query: 838 AGNQPGGNPSPGGATTSKSC 857
A + GG+ SK+C
Sbjct: 841 AEDSGGGDDK-----KSKTC 855
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 923 bits (2386), Expect = 0.0
Identities = 446/578 (77%), Positives = 496/578 (85%), Gaps = 4/578 (0%)
Query: 282 MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWA 341
MTK+KEFFDVW VLMGE PYSGPRTPDGREI FYKVIDYILHGKE+IKVIP P DHWA
Sbjct: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
Query: 342 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA 401
L SGLP+YVA++G ICNIMNA A++ F FQ+ LD+SGW+IKNVLSMPIVNKKEEIVGVA
Sbjct: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
Query: 402 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD 461
TFYNRKDGKPFDE DE LMESLTQFLGWSV+N DTY+ MNKLENRKDI QD+V YHVKCD
Sbjct: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
Query: 462 NEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKC 521
+EIQ IL TR GKEP +C+E+EL EIL+ ELP ++I +FHFSDL TEL+LVKC
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
Query: 522 GIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLK 581
GIQMYYEL VV KF IPQE LVRF++S+SKGYR+ITYHNWRHGFNV QTMF+LL+TGKLK
Sbjct: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300
Query: 582 RYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRD 641
Y+TDLEA AMVTA CHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGK LL +
Sbjct: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360
Query: 642 ESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYM 701
E+LNI+QNLNRRQHEH IH+MDIAIIATDLALYFKKR MFQKIVD+SK Y+ ++ W +Y+
Sbjct: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420
Query: 702 MLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMM 761
LE TRKEIVMAMMMTACDLSAITKPWEVQS+VALLVAAEFWEQGDLERTVL Q PIPMM
Sbjct: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480
Query: 762 DRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMK 821
DRNKA ELPKLQVGFIDFVCTFVYKEFSRFHEEI PM D + NNRKEWKALADEY+AK+K
Sbjct: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540
Query: 822 VQEEKKQKQQSAKSAAAGNQPGGNPSPGGATTSKSCCI 859
EEK+++++ A G P+P S +CCI
Sbjct: 541 ALEEKEEEERVAAKKVGTEICNGGPAP----KSSTCCI 574
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/190 (26%), Positives = 82/190 (43%), Gaps = 33/190 (17%)
Query: 136 LDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTE--YKTKNILASPIMNGKD-VVAII 192
L G+ +VA S I N+ N DE F L + + KN+L+ PI+N K+ +V +
Sbjct: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
Query: 193 MAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWS--GSKVFE 250
N+ DG F ++D E+L++ L Q L WS + ++
Sbjct: 121 TFYNRKDGKPFDEQD-EVLMESLT----------------------QFLGWSVMNTDTYD 157
Query: 251 ELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQ---KEFFDVWPVLMGEV--PPYSGP 305
++ +E + A V + CDR + L+ T+ KE D +GE+ GP
Sbjct: 158 KMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGP 217
Query: 306 RTPDGREINF 315
T D E +F
Sbjct: 218 TTFDIYEFHF 227
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 431 bits (1109), Expect = e-120
Identities = 248/766 (32%), Positives = 404/766 (52%), Gaps = 68/766 (8%)
Query: 57 ESEIIFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYR-TRNGIAELATRLFNV 115
E + +L++D +L + ++ +C ++ ADR SLF+ G L ++ F+V
Sbjct: 201 ERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV 260
Query: 116 HKDAVLEDCLVMPDQ-EIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKT 174
H L C + E+ P GI+G+V + N+P+ +D F D +D LT YKT
Sbjct: 261 HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKT 320
Query: 175 KNILASPIMNGK-DVVAIIMAVNKV-DGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHN 232
K++L PI + +++ + A+NK+ +G+ FT+ DE+++ YL F + + L
Sbjct: 321 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 380
Query: 233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLD-----MTKQKE 287
E R + LL + +FEE TD+E+ K ++ + L C+R SV LL+ + K +
Sbjct: 381 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTK 440
Query: 288 FFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLP 347
F++ P+ E +F + ++ + W + + +
Sbjct: 441 SFELM-----------SPKCSADAENSFKESMEKSSYSD-------------WLINNSIA 476
Query: 348 AYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRK 407
VA GL NI +A + F + + + SG+ I++VL +PI N +I+GVA NR
Sbjct: 477 ELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIGVAQVLNRL 534
Query: 408 DGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQK 467
DGKPFD+ D+ L E+ F G + N Y+ + K ++ + D++ YH C E+ K
Sbjct: 535 DGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDK 594
Query: 468 ILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYY 527
A +P + I+ HF D L ++ ++M+
Sbjct: 595 FKA----------------------ANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFM 632
Query: 528 ELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDL 587
EL +V KF I E L R++ ++ K YR + YHNWRH FNV Q MF++L T + T++
Sbjct: 633 ELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEV 692
Query: 588 EALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNI 646
E LA++ CHD+DHRGTNN +Q KS + LA+L+G S+ LE HH +L+ E NI
Sbjct: 693 EILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNI 752
Query: 647 FQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQT 706
F NL+ +++ + ++ +I+ATDL LYF++RT F ++V + E +W +
Sbjct: 753 FANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS-----KGEYDWN-----IKN 802
Query: 707 RKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKA 766
++I +M+MTACDL A+TKPWE+ QVA LV +EF+EQGD ER L+ P + DRN+
Sbjct: 803 HRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRK 862
Query: 767 DELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKAL 812
DELP+LQ+ +ID +C +Y+ + + ++ PMLD + NR +W+ L
Sbjct: 863 DELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 393 bits (1010), Expect = e-109
Identities = 251/785 (31%), Positives = 406/785 (51%), Gaps = 74/785 (9%)
Query: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMY-RTRNGIAELATRLFNVHKDA 119
+ +L++D +L + + L+ ADR SLF+ + L +RLF+V + +
Sbjct: 152 LLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGS 211
Query: 120 VLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILA 179
LE+ + + I + GIVGHVA + N+ + ED F VD +T YKT++IL
Sbjct: 212 TLEE---VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 268
Query: 180 SPIMNGKD-VVAIIMAVNKVDGSH--FTKRDEEILLKYLNFANLIMKVYHLSYLHNCETR 236
PI N ++ VV + A+NK G+ FT++DE+ YL F +++ L E +
Sbjct: 269 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 328
Query: 237 RGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLM 296
R Q+LL S +FEE +E K T+ +F+ + ++ ++D F V+ +
Sbjct: 329 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMEC 388
Query: 297 GEVPPYSGP--RTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNG 354
E+ S R D +IN Y Y+ + E + IP+ D P G
Sbjct: 389 EELEKSSDTLTREHDANKIN-YMYAQYVKNTMEPLN-IPDVSKD-----KRFPWTTENTG 441
Query: 355 LICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVN-KKEEIVGVATFYNRKDG---- 409
+ + I+++L PI N KK +++GV N+ +
Sbjct: 442 NV---------------------NQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK 480
Query: 410 -KPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKI 468
KPF+ DE +E+ F G + N YE++ + ++ + +++ YH EE +
Sbjct: 481 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-- 538
Query: 469 LKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYE 528
EL + A +P A +I F FSD L++LE C I+M+ +
Sbjct: 539 -----------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTD 581
Query: 529 LKVVDKFHIPQEALVRFMYSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDL 587
L +V F + E L R++ S+ K YRK + YHNWRH FN Q MF+ L GK++ TDL
Sbjct: 582 LNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDL 641
Query: 588 EALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIF 647
E LA++ AA HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L I
Sbjct: 642 EILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQIL 701
Query: 648 QNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTR 707
L+ +++ + ++ AI+ATDLALY K+R F +++ ++ Q+ + + +
Sbjct: 702 SGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKN----------QFNLEDPHQ 751
Query: 708 KEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKAD 767
KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L P +M+R K +
Sbjct: 752 KELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKN 811
Query: 768 ELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
++P +QVGFID +C +Y+ + E+ P+LDG NR++W+ALA++ + KM + E
Sbjct: 812 KIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE-KMLINGESG 870
Query: 828 QKQQS 832
Q +++
Sbjct: 871 QAKRN 875
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 393 bits (1010), Expect = e-109
Identities = 251/785 (31%), Positives = 406/785 (51%), Gaps = 74/785 (9%)
Query: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMY-RTRNGIAELATRLFNVHKDA 119
+ +L++D +L + + L+ ADR SLF+ + L +RLF+V + +
Sbjct: 100 LLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGS 159
Query: 120 VLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILA 179
LE+ + + I + GIVGHVA + N+ + ED F VD +T YKT++IL
Sbjct: 160 TLEE---VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 216
Query: 180 SPIMNGKD-VVAIIMAVNKVDGSH--FTKRDEEILLKYLNFANLIMKVYHLSYLHNCETR 236
PI N ++ VV + A+NK G+ FT++DE+ YL F +++ L E +
Sbjct: 217 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 276
Query: 237 RGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLM 296
R Q+LL S +FEE +E K T+ +F+ + ++ ++D F V+ +
Sbjct: 277 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMEC 336
Query: 297 GEVPPYSGP--RTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNG 354
E+ S R D +IN Y Y+ + E + IP+ D P G
Sbjct: 337 EELEKSSDTLTREHDANKIN-YMYAQYVKNTMEPLN-IPDVSKD-----KRFPWTTENTG 389
Query: 355 LICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVN-KKEEIVGVATFYNRKDG---- 409
+ + I+++L PI N KK +++GV N+ +
Sbjct: 390 NV---------------------NQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK 428
Query: 410 -KPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKI 468
KPF+ DE +E+ F G + N YE++ + ++ + +++ YH EE +
Sbjct: 429 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-- 486
Query: 469 LKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYE 528
EL + A +P A +I F FSD L++LE C I+M+ +
Sbjct: 487 -----------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTD 529
Query: 529 LKVVDKFHIPQEALVRFMYSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDL 587
L +V F + E L R++ S+ K YRK + YHNWRH FN Q MF+ L GK++ TDL
Sbjct: 530 LNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDL 589
Query: 588 EALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIF 647
E LA++ AA HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L I
Sbjct: 590 EILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQIL 649
Query: 648 QNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTR 707
L+ +++ + ++ AI+ATDLALY K+R F +++ ++ Q+ + + +
Sbjct: 650 SGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKN----------QFNLEDPHQ 699
Query: 708 KEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKAD 767
KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L P +M+R K +
Sbjct: 700 KELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKN 759
Query: 768 ELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
++P +QVGFID +C +Y+ + E+ P+LDG NR++W+ALA++ + KM + E
Sbjct: 760 KIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE-KMLINGESG 818
Query: 828 QKQQS 832
Q +++
Sbjct: 819 QAKRN 823
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 393 bits (1010), Expect = e-109
Identities = 251/785 (31%), Positives = 406/785 (51%), Gaps = 74/785 (9%)
Query: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMY-RTRNGIAELATRLFNVHKDA 119
+ +L++D +L + + L+ ADR SLF+ + L +RLF+V + +
Sbjct: 110 LLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGS 169
Query: 120 VLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILA 179
LE+ + + I + GIVGHVA + N+ + ED F VD +T YKT++IL
Sbjct: 170 TLEE---VSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILC 226
Query: 180 SPIMNGKD-VVAIIMAVNKVDGSH--FTKRDEEILLKYLNFANLIMKVYHLSYLHNCETR 236
PI N ++ VV + A+NK G+ FT++DE+ YL F +++ L E +
Sbjct: 227 MPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENK 286
Query: 237 RGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLM 296
R Q+LL S +FEE +E K T+ +F+ + ++ ++D F V+ +
Sbjct: 287 RNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMEC 346
Query: 297 GEVPPYSGP--RTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNG 354
E+ S R D +IN Y Y+ + E + IP+ D P G
Sbjct: 347 EELEKSSDTLTREHDANKIN-YMYAQYVKNTMEPLN-IPDVSKD-----KRFPWTTENTG 399
Query: 355 LICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVN-KKEEIVGVATFYNRKDG---- 409
+ + I+++L PI N KK +++GV N+ +
Sbjct: 400 NV---------------------NQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK 438
Query: 410 -KPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKI 468
KPF+ DE +E+ F G + N YE++ + ++ + +++ YH EE +
Sbjct: 439 VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETR-- 496
Query: 469 LKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYE 528
EL + A +P A +I F FSD L++LE C I+M+ +
Sbjct: 497 -----------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTD 539
Query: 529 LKVVDKFHIPQEALVRFMYSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDL 587
L +V F + E L R++ S+ K YRK + YHNWRH FN Q MF+ L GK++ TDL
Sbjct: 540 LNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDL 599
Query: 588 EALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIF 647
E LA++ AA HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L I
Sbjct: 600 EILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQIL 659
Query: 648 QNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTR 707
L+ +++ + ++ AI+ATDLALY K+R F +++ ++ Q+ + + +
Sbjct: 660 SGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKN----------QFNLEDPHQ 709
Query: 708 KEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKAD 767
KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L P +M+R K +
Sbjct: 710 KELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKN 769
Query: 768 ELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
++P +QVGFID +C +Y+ + E+ P+LDG NR++W+ALA++ + KM + E
Sbjct: 770 KIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE-KMLINGESG 828
Query: 828 QKQQS 832
Q +++
Sbjct: 829 QAKRN 833
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 389 bits (998), Expect = e-108
Identities = 222/663 (33%), Positives = 356/663 (53%), Gaps = 66/663 (9%)
Query: 158 EDEHFCDFVDILTEYKTKNILASPIMNGK-DVVAIIMAVNKV-DGSHFTKRDEEILLKYL 215
+D F D +D LT YKTK++L PI + +++ + A+NK+ +G+ FT+ DE+++ YL
Sbjct: 54 KDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYL 113
Query: 216 NFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRY 275
F + + L E R + LL + +FEE TD+E+ K ++ + L C+R
Sbjct: 114 PFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERC 173
Query: 276 SVGLLD-----MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIK 330
SV LL+ + K + F++ P+ E +F + ++ +
Sbjct: 174 SVLLLEDIESPVVKFTKSFELM-----------SPKCSADAENSFKESMEKSSYSD---- 218
Query: 331 VIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPI 390
W + + + VA GL NI +A + F + + + SG+ I++VL +PI
Sbjct: 219 ---------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPI 267
Query: 391 VNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIF 450
N +I+GVA NR DGKPFD+ D+ L E+ F G + N Y+ + K ++ +
Sbjct: 268 WNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVA 327
Query: 451 QDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSD 510
D++ YH C E+ K A +P + I+ HF D
Sbjct: 328 LDVLSYHATCSKAEVDKFKA----------------------ANIPLVSELAIDDIHFDD 365
Query: 511 LPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQT 570
L ++ ++M+ EL +V KF I E L R++ ++ K YR + YHNWRH FNV Q
Sbjct: 366 FSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQL 425
Query: 571 MFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILER 629
MF++L T + T++E LA++ CHD+DHRGTNN +Q KS + LA+L+G S+ LE
Sbjct: 426 MFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEH 485
Query: 630 HHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSK 689
HH +L+ E NIF NL+ +++ + ++ +I+ATDL LYF++RT F ++V
Sbjct: 486 HHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS--- 542
Query: 690 TYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLE 749
+ E +W + ++I +M+MTACDL A+TKPWE+ QVA LV +EF+EQGD E
Sbjct: 543 --KGEYDWN-----IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRE 595
Query: 750 RTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEW 809
R L+ P + DRN+ DELP+LQ+ +ID +C +Y+ + + ++ PMLD + NR +W
Sbjct: 596 RLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKW 655
Query: 810 KAL 812
+ L
Sbjct: 656 EEL 658
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 349 bits (896), Expect = 5e-96
Identities = 201/605 (33%), Positives = 318/605 (52%), Gaps = 64/605 (10%)
Query: 214 YLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCD 273
YL F + + L E R + LL + +FEE TD+E+ K ++ + L C+
Sbjct: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
Query: 274 RYSVGLLD-----MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKED 328
R SV LL+ + K + F++ P+ E +F + ++ +
Sbjct: 64 RCSVLLLEDIESPVVKFTKSFELM-----------SPKCSADAENSFKESMEKSSYSD-- 110
Query: 329 IKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSM 388
W + + + VA GL NI +A + F + + + SG+ I++VL +
Sbjct: 111 -----------WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCV 157
Query: 389 PIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKD 448
PI N +I+GVA NR DGKPFD+ D+ L E+ F G + N Y+ + K ++
Sbjct: 158 PIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQS 217
Query: 449 IFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHF 508
+ D++ YH C E+ K A +P + I+ HF
Sbjct: 218 VALDVLSYHATCSKAEVDKFKA----------------------ANIPLVSELAIDDIHF 255
Query: 509 SDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVG 568
D L ++ ++M+ EL +V KF I E L R++ ++ K YR + YHNWRH FNV
Sbjct: 256 DDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVC 315
Query: 569 QTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSIL 627
Q MF++L T + T++E LA++ CHD+DHRGTNN +Q KS + LA+L+G S+ L
Sbjct: 316 QLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATL 375
Query: 628 ERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQ 687
E HH +L+ E NIF NL+ +++ + ++ +I+ATDL LYF++RT F ++V
Sbjct: 376 EHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS- 434
Query: 688 SKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGD 747
+ E +W + ++I +M+MTACDL A+TKPWE+ QVA LV +EF+EQGD
Sbjct: 435 ----KGEYDWN-----IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGD 485
Query: 748 LERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRK 807
ER L+ P + DRN+ DELP+LQ+ +ID +C +Y+ + + ++ PMLD + NR
Sbjct: 486 RERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRS 545
Query: 808 EWKAL 812
+W+ L
Sbjct: 546 KWEEL 550
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 334 bits (857), Expect = 2e-91
Identities = 174/474 (36%), Positives = 269/474 (56%), Gaps = 35/474 (7%)
Query: 340 WALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVG 399
W + + + VA GL NI +A + F + + + SG+ I++VL +PI N +I+G
Sbjct: 25 WLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIG 82
Query: 400 VATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVK 459
VA NR DGKPFD+ D+ L E+ F G + N Y+ + K ++ + D++ YH
Sbjct: 83 VAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHAT 142
Query: 460 CDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELV 519
C E+ K A +P + I+ HF D L ++
Sbjct: 143 CSKAEVDKFKA----------------------ANIPLVSELAIDDIHFDDFSLDVDAMI 180
Query: 520 KCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGK 579
++M+ EL +V KF I E L R++ ++ K YR + YHNWRH FNV Q MF++L T
Sbjct: 181 TAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAG 240
Query: 580 LKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTL 638
+ T++E LA++ CHD+DHRGTNN +Q KS + LA+L+G S+ LE HH +
Sbjct: 241 FQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMI 300
Query: 639 LRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWT 698
L+ E NIF NL+ +++ + ++ +I+ATDL LYF++RT F ++V + E +W
Sbjct: 301 LQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVS-----KGEYDWN 355
Query: 699 QYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPI 758
+ ++I +M+MTACDL A+TKPWE+ QVA LV +EF+EQGD ER L+ P
Sbjct: 356 -----IKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPS 410
Query: 759 PMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKAL 812
+ DRN+ DELP+LQ+ +ID +C +Y+ + + ++ PMLD + NR +W+ L
Sbjct: 411 AIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 464
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 256 bits (653), Expect = 8e-68
Identities = 188/717 (26%), Positives = 328/717 (45%), Gaps = 90/717 (12%)
Query: 112 LFNVHKDAVLEDCLVMPD----QEIVFPLDMGIVGHVAHSKKIANVPN-TEEDEHFCDFV 166
L V +D + C V+ D +E+ FPL G +G V KK + + T ED +
Sbjct: 255 LLLVSEDNLQLSCKVIGDKVLGEEVSFPLT-GCLGQVVEDKKSIQLKDLTSED---VQQL 310
Query: 167 DILTEYKTKNILASPIMNGK--DVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMK- 223
+ + + +L P+++ VVA+ A NK++G FT DE ++ ++ + ++
Sbjct: 311 QSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTS 370
Query: 224 --VYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLD 281
+ CE Q LL +F L D+ + + R N + SV LLD
Sbjct: 371 TLAFQKEQKLKCEC---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLD 427
Query: 282 MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWA 341
+ KV D + E ++ P D
Sbjct: 428 QNELVA-----------------------------KVFDGGVVDDESYEI--RIPADQ-- 454
Query: 342 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA 401
G+ +VA G I NI +A A F + D +G+ +N+L PI N+ +E++GVA
Sbjct: 455 ---GIAGHVATTGQILNIPDAYAHPLFYRGVD--DSTGFRTRNILCFPIKNENQEVIGVA 509
Query: 402 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD 461
N+ +G F + DE L + + + G S+ + Y+ +N+ + R + +++ YH+K
Sbjct: 510 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 569
Query: 462 NEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKC 521
++E K+L G +P + A F ++ L E +
Sbjct: 570 DDEYTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMA 609
Query: 522 GIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLK 581
+ M ++ ++ + I L RF + KGYR YHNW H F+V + L +L
Sbjct: 610 ILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELT 669
Query: 582 RYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKTLL 639
Y D+E A+ + CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L
Sbjct: 670 NYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAIL 729
Query: 640 RDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQ 699
NIF + +R+ ++ + +M I+ATDLA + + QK+ + ++Q
Sbjct: 730 NTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ---- 785
Query: 700 YMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIP 759
+++ ++MT+CDLS TK W+ ++A L+ EF+ QGDLE+ + P+
Sbjct: 786 -------HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPME 837
Query: 760 MMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEY 816
MMDR KA +P+LQ+ F++ + +YK + + + + +NR+ W ++ ++
Sbjct: 838 MMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 893
Score = 67.8 bits (164), Expect = 4e-11
Identities = 81/302 (26%), Positives = 130/302 (43%), Gaps = 57/302 (18%)
Query: 31 KLISDLLGAKEAAVDFSNYHSPSSMEESEIIFD----LLRDFQENLQTEKCIFNVMKKLC 86
KL DL ++ V +H S++ S + F L + Q LQ K +F + +
Sbjct: 343 KLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVS 402
Query: 87 FLLQ-----------ADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFP 135
LLQ A+ S+F+ EL ++F+ V++D EI P
Sbjct: 403 VLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD---GGVVDD----ESYEIRIP 451
Query: 136 LDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMN-GKDVVAIIMA 194
D GI GHVA + +I N+P+ F VD T ++T+NIL PI N ++V+ +
Sbjct: 452 ADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAEL 511
Query: 195 VNKVDGSHFTKRDEE----------------ILLKYLNFANL------IMKVYHLSYLHN 232
VNK++G F+K DE+ +L K +N A M +YH+ +
Sbjct: 512 VNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDD 571
Query: 233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVW 292
T+ LL G + + I+ F YT R+ L D S+ +L M + F + +
Sbjct: 572 EYTK----LLHDG---IQPVAAIDSNFASFTYTPRS-LPEDDTSMAILSMLQDMNFINNY 623
Query: 293 PV 294
+
Sbjct: 624 KI 625
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 256 bits (653), Expect = 8e-68
Identities = 188/717 (26%), Positives = 328/717 (45%), Gaps = 90/717 (12%)
Query: 112 LFNVHKDAVLEDCLVMPD----QEIVFPLDMGIVGHVAHSKKIANVPN-TEEDEHFCDFV 166
L V +D + C V+ D +E+ FPL G +G V KK + + T ED +
Sbjct: 257 LLLVSEDNLQLSCKVIGDKVLGEEVSFPLT-GCLGQVVEDKKSIQLKDLTSED---VQQL 312
Query: 167 DILTEYKTKNILASPIMNGK--DVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMK- 223
+ + + +L P+++ VVA+ A NK++G FT DE ++ ++ + ++
Sbjct: 313 QSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTS 372
Query: 224 --VYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLD 281
+ CE Q LL +F L D+ + + R N + SV LLD
Sbjct: 373 TLAFQKEQKLKCEC---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLD 429
Query: 282 MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWA 341
+ KV D + E ++ P D
Sbjct: 430 QNELVA-----------------------------KVFDGGVVDDESYEI--RIPADQ-- 456
Query: 342 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA 401
G+ +VA G I NI +A A F + D +G+ +N+L PI N+ +E++GVA
Sbjct: 457 ---GIAGHVATTGQILNIPDAYAHPLFYRGVD--DSTGFRTRNILCFPIKNENQEVIGVA 511
Query: 402 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD 461
N+ +G F + DE L + + + G S+ + Y+ +N+ + R + +++ YH+K
Sbjct: 512 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 571
Query: 462 NEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKC 521
++E K+L G +P + A F ++ L E +
Sbjct: 572 DDEYTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMA 611
Query: 522 GIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLK 581
+ M ++ ++ + I L RF + KGYR YHNW H F+V + L +L
Sbjct: 612 ILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELT 671
Query: 582 RYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKTLL 639
Y D+E A+ + CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L
Sbjct: 672 NYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAIL 731
Query: 640 RDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQ 699
NIF + +R+ ++ + +M I+ATDLA + + QK+ + ++Q
Sbjct: 732 NTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ---- 787
Query: 700 YMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIP 759
+++ ++MT+CDLS TK W+ ++A L+ EF+ QGDLE+ + P+
Sbjct: 788 -------HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPME 839
Query: 760 MMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEY 816
MMDR KA +P+LQ+ F++ + +YK + + + + +NR+ W ++ ++
Sbjct: 840 MMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 895
Score = 67.8 bits (164), Expect = 4e-11
Identities = 81/302 (26%), Positives = 130/302 (43%), Gaps = 57/302 (18%)
Query: 31 KLISDLLGAKEAAVDFSNYHSPSSMEESEIIFD----LLRDFQENLQTEKCIFNVMKKLC 86
KL DL ++ V +H S++ S + F L + Q LQ K +F + +
Sbjct: 345 KLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVS 404
Query: 87 FLLQ-----------ADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFP 135
LLQ A+ S+F+ EL ++F+ V++D EI P
Sbjct: 405 VLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD---GGVVDD----ESYEIRIP 453
Query: 136 LDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMN-GKDVVAIIMA 194
D GI GHVA + +I N+P+ F VD T ++T+NIL PI N ++V+ +
Sbjct: 454 ADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAEL 513
Query: 195 VNKVDGSHFTKRDEE----------------ILLKYLNFANL------IMKVYHLSYLHN 232
VNK++G F+K DE+ +L K +N A M +YH+ +
Sbjct: 514 VNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDD 573
Query: 233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVW 292
T+ LL G + + I+ F YT R+ L D S+ +L M + F + +
Sbjct: 574 EYTK----LLHDG---IQPVAAIDSNFASFTYTPRS-LPEDDTSMAILSMLQDMNFINNY 625
Query: 293 PV 294
+
Sbjct: 626 KI 627
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 256 bits (653), Expect = 8e-68
Identities = 188/717 (26%), Positives = 328/717 (45%), Gaps = 90/717 (12%)
Query: 112 LFNVHKDAVLEDCLVMPD----QEIVFPLDMGIVGHVAHSKKIANVPN-TEEDEHFCDFV 166
L V +D + C V+ D +E+ FPL G +G V KK + + T ED +
Sbjct: 264 LLLVSEDNLQLSCKVIGDKVLGEEVSFPLT-GCLGQVVEDKKSIQLKDLTSED---VQQL 319
Query: 167 DILTEYKTKNILASPIMNGK--DVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMK- 223
+ + + +L P+++ VVA+ A NK++G FT DE ++ ++ + ++
Sbjct: 320 QSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTS 379
Query: 224 --VYHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLD 281
+ CE Q LL +F L D+ + + R N + SV LLD
Sbjct: 380 TLAFQKEQKLKCEC---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLD 436
Query: 282 MTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWA 341
+ KV D + E ++ P D
Sbjct: 437 QNELVA-----------------------------KVFDGGVVDDESYEI--RIPADQ-- 463
Query: 342 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA 401
G+ +VA G I NI +A A F + D +G+ +N+L PI N+ +E++GVA
Sbjct: 464 ---GIAGHVATTGQILNIPDAYAHPLFYRGVD--DSTGFRTRNILCFPIKNENQEVIGVA 518
Query: 402 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD 461
N+ +G F + DE L + + + G S+ + Y+ +N+ + R + +++ YH+K
Sbjct: 519 ELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS 578
Query: 462 NEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKC 521
++E K+L G +P + A F ++ L E +
Sbjct: 579 DDEYTKLLHD----GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMA 618
Query: 522 GIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLK 581
+ M ++ ++ + I L RF + KGYR YHNW H F+V + L +L
Sbjct: 619 ILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELT 678
Query: 582 RYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKTLL 639
Y D+E A+ + CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L
Sbjct: 679 NYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAIL 738
Query: 640 RDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQ 699
NIF + +R+ ++ + +M I+ATDLA + + QK+ + ++Q
Sbjct: 739 NTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ---- 794
Query: 700 YMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIP 759
+++ ++MT+CDLS TK W+ ++A L+ EF+ QGDLE+ + P+
Sbjct: 795 -------HHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPME 846
Query: 760 MMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEY 816
MMDR KA +P+LQ+ F++ + +YK + + + + +NR+ W ++ ++
Sbjct: 847 MMDREKA-YIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 902
Score = 67.8 bits (164), Expect = 4e-11
Identities = 81/302 (26%), Positives = 130/302 (43%), Gaps = 57/302 (18%)
Query: 31 KLISDLLGAKEAAVDFSNYHSPSSMEESEIIFD----LLRDFQENLQTEKCIFNVMKKLC 86
KL DL ++ V +H S++ S + F L + Q LQ K +F + +
Sbjct: 352 KLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVS 411
Query: 87 FLLQ-----------ADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFP 135
LLQ A+ S+F+ EL ++F+ V++D EI P
Sbjct: 412 VLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD---GGVVDD----ESYEIRIP 460
Query: 136 LDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMN-GKDVVAIIMA 194
D GI GHVA + +I N+P+ F VD T ++T+NIL PI N ++V+ +
Sbjct: 461 ADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAEL 520
Query: 195 VNKVDGSHFTKRDEE----------------ILLKYLNFANL------IMKVYHLSYLHN 232
VNK++G F+K DE+ +L K +N A M +YH+ +
Sbjct: 521 VNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDD 580
Query: 233 CETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVW 292
T+ LL G + + I+ F YT R+ L D S+ +L M + F + +
Sbjct: 581 EYTK----LLHDG---IQPVAAIDSNFASFTYTPRS-LPEDDTSMAILSMLQDMNFINNY 632
Query: 293 PV 294
+
Sbjct: 633 KI 634
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 238 bits (608), Expect = 1e-62
Identities = 183/679 (26%), Positives = 302/679 (44%), Gaps = 72/679 (10%)
Query: 135 PLDMG--IVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNG-KDVVAI 191
P+ G + +VA S+K V + DE F + + + +++L PI+ D++ I
Sbjct: 144 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 203
Query: 192 IMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEE 251
+ F +E+ L +A++ + + +T LL F+
Sbjct: 204 LELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDN 263
Query: 252 LTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGR 311
+ I+ + + +N DR ++ +D ++ + D++ + G
Sbjct: 264 IVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI---------------GE 308
Query: 312 EINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQ 371
E KE V +++ G+ VA+ G + NI +A A+ F
Sbjct: 309 E-------------KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP--RFN 353
Query: 372 KEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSV 431
+E +G+ +N+L MPIV++ ++GV N+ G F + DE + F ++
Sbjct: 354 REVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALAL 412
Query: 432 LNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEIL 491
+ Y + E + + + YH C +EE Q ++
Sbjct: 413 HCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM---------------------- 450
Query: 492 QAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSK 551
Q LP EI FHF P E + GI +Y + E L RF+ S+ K
Sbjct: 451 QFTLPVRLCKEIELFHFDIGPF---ENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKK 507
Query: 552 GYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ 611
YR++ YHNW+H V M+++L FTDLE ++ A CHD+DHRG +N Y
Sbjct: 508 NYRRVPYHNWKHAVTVAHCMYAILQNNHT--LFTDLERKGLLIACLCHDLDHRGFSNSYL 565
Query: 612 MKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDL 671
K +PLA L+ +S +E+HH ++L+ E NIF L+ ++E + ++ AIIATDL
Sbjct: 566 QKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDL 625
Query: 672 ALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQ 731
ALYF R K E + + Q+ ++ V+ +MMTACDL ++TK W V
Sbjct: 626 ALYFGNR----------KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVT 675
Query: 732 SQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRF 791
A + AEFW +GD E L PIPMMDR+K DE+P+ Q+GF + V Y ++
Sbjct: 676 KLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 734
Query: 792 HEEITPMLDGITNNRKEWK 810
P+L +N +W+
Sbjct: 735 LPPTEPLLKACRDNLSQWE 753
Score = 79.7 bits (195), Expect = 1e-14
Identities = 51/175 (29%), Positives = 93/175 (53%), Gaps = 7/175 (4%)
Query: 56 EESEIIFDLLRDFQENLQT-EKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFN 114
E ++ + D+ + + +N+ + + ++M L+ ADR +LF +N EL + LF+
Sbjct: 248 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN--KELYSDLFD 305
Query: 115 VHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKT 174
+ ++ + + +EI F ++ GI G VA + ++ N+P+ D F VD+ T Y T
Sbjct: 306 IGEEKEGKP-VFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT 364
Query: 175 KNILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIM---KVYH 226
+NIL PI++ V+ ++ VNK+ GS F+K DE + F L + +YH
Sbjct: 365 RNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 419
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 238 bits (608), Expect = 1e-62
Identities = 183/679 (26%), Positives = 302/679 (44%), Gaps = 72/679 (10%)
Query: 135 PLDMG--IVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILASPIMNG-KDVVAI 191
P+ G + +VA S+K V + DE F + + + +++L PI+ D++ I
Sbjct: 154 PITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGI 213
Query: 192 IMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQILLWSGSKVFEE 251
+ F +E+ L +A++ + + +T LL F+
Sbjct: 214 LELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDN 273
Query: 252 LTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGR 311
+ I+ + + +N DR ++ +D ++ + D++ + G
Sbjct: 274 IVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI---------------GE 318
Query: 312 EINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQ 371
E KE V +++ G+ VA+ G + NI +A A+ F
Sbjct: 319 E-------------KEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP--RFN 363
Query: 372 KEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSV 431
+E +G+ +N+L MPIV++ ++GV N+ G F + DE + F ++
Sbjct: 364 REVDLYTGYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALAL 422
Query: 432 LNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEIL 491
+ Y + E + + + YH C +EE Q ++
Sbjct: 423 HCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLM---------------------- 460
Query: 492 QAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSK 551
Q LP EI FHF P E + GI +Y + E L RF+ S+ K
Sbjct: 461 QFTLPVRLCKEIELFHFDIGPF---ENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKK 517
Query: 552 GYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ 611
YR++ YHNW+H V M+++L FTDLE ++ A CHD+DHRG +N Y
Sbjct: 518 NYRRVPYHNWKHAVTVAHCMYAILQNNHT--LFTDLERKGLLIACLCHDLDHRGFSNSYL 575
Query: 612 MKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDL 671
K +PLA L+ +S +E+HH ++L+ E NIF L+ ++E + ++ AIIATDL
Sbjct: 576 QKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDL 635
Query: 672 ALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQ 731
ALYF R K E + + Q+ ++ V+ +MMTACDL ++TK W V
Sbjct: 636 ALYFGNR----------KQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVT 685
Query: 732 SQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRF 791
A + AEFW +GD E L PIPMMDR+K DE+P+ Q+GF + V Y ++
Sbjct: 686 KLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQI 744
Query: 792 HEEITPMLDGITNNRKEWK 810
P+L +N +W+
Sbjct: 745 LPPTEPLLKACRDNLSQWE 763
Score = 79.7 bits (195), Expect = 1e-14
Identities = 51/175 (29%), Positives = 93/175 (53%), Gaps = 7/175 (4%)
Query: 56 EESEIIFDLLRDFQENLQT-EKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFN 114
E ++ + D+ + + +N+ + + ++M L+ ADR +LF +N EL + LF+
Sbjct: 258 ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKN--KELYSDLFD 315
Query: 115 VHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKT 174
+ ++ + + +EI F ++ GI G VA + ++ N+P+ D F VD+ T Y T
Sbjct: 316 IGEEKEGKP-VFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTT 374
Query: 175 KNILASPIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIM---KVYH 226
+NIL PI++ V+ ++ VNK+ GS F+K DE + F L + +YH
Sbjct: 375 RNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 429
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 150 bits (378), Expect = 6e-36
Identities = 109/343 (31%), Positives = 178/343 (51%), Gaps = 13/343 (3%)
Query: 489 EILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYS 548
E+L EL + +K+ +N F SD L ++ E ++ KF IP + +V +M +
Sbjct: 302 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 360
Query: 549 LSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTN 607
L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G +
Sbjct: 361 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 420
Query: 608 NLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAI 666
N + + + + LA ++ S+LE HHL G LL++++ +IFQNL++RQ + M+ +
Sbjct: 421 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 480
Query: 667 IATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSAIT 725
+ATD++ + + +V+ K S ++L+ I V+ M+ DLS T
Sbjct: 481 LATDMSKHMTLLADLKTMVETKKVTSS-----GVLLLDNYSDRIQVLRNMVHCADLSNPT 535
Query: 726 KPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVY 785
KP E+ Q + AEF++QGD ER PM D++ A + K QVGFID++ ++
Sbjct: 536 KPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLW 593
Query: 786 KEFSRF-HEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
+ ++ H + +LD + +NR +W A +EE +
Sbjct: 594 ETWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESR 635
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 150 bits (378), Expect = 6e-36
Identities = 109/343 (31%), Positives = 178/343 (51%), Gaps = 13/343 (3%)
Query: 489 EILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYS 548
E+L EL + +K+ +N F SD L ++ E ++ KF IP + +V +M +
Sbjct: 337 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 395
Query: 549 LSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTN 607
L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G +
Sbjct: 396 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 455
Query: 608 NLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAI 666
N + + + + LA ++ S+LE HHL G LL++++ +IFQNL++RQ + M+ +
Sbjct: 456 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 515
Query: 667 IATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSAIT 725
+ATD++ + + +V+ K S ++L+ I V+ M+ DLS T
Sbjct: 516 LATDMSKHMTLLADLKTMVETKKVTSS-----GVLLLDNYSDRIQVLRNMVHCADLSNPT 570
Query: 726 KPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVY 785
KP E+ Q + AEF++QGD ER PM D++ A + K QVGFID++ ++
Sbjct: 571 KPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLW 628
Query: 786 KEFSRF-HEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
+ ++ H + +LD + +NR +W A +EE +
Sbjct: 629 ETWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESR 670
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 150 bits (378), Expect = 6e-36
Identities = 109/343 (31%), Positives = 178/343 (51%), Gaps = 13/343 (3%)
Query: 489 EILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYS 548
E+L EL + +K+ +N F SD L ++ E ++ KF IP + +V +M +
Sbjct: 363 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 421
Query: 549 LSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTN 607
L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G +
Sbjct: 422 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 481
Query: 608 NLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAI 666
N + + + + LA ++ S+LE HHL G LL++++ +IFQNL++RQ + M+ +
Sbjct: 482 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 541
Query: 667 IATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSAIT 725
+ATD++ + + +V+ K S ++L+ I V+ M+ DLS T
Sbjct: 542 LATDMSKHMTLLADLKTMVETKKVTSS-----GVLLLDNYSDRIQVLRNMVHCADLSNPT 596
Query: 726 KPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVY 785
KP E+ Q + AEF++QGD ER PM D++ A + K QVGFID++ ++
Sbjct: 597 KPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLW 654
Query: 786 KEFSRF-HEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
+ ++ H + +LD + +NR +W A +EE +
Sbjct: 655 ETWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESR 696
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 150 bits (378), Expect = 6e-36
Identities = 109/343 (31%), Positives = 178/343 (51%), Gaps = 13/343 (3%)
Query: 489 EILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYS 548
E+L EL + +K+ +N F SD L ++ E ++ KF IP + +V +M +
Sbjct: 124 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 182
Query: 549 LSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTN 607
L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G +
Sbjct: 183 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 242
Query: 608 NLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAI 666
N + + + + LA ++ S+LE HHL G LL++++ +IFQNL++RQ + M+ +
Sbjct: 243 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 302
Query: 667 IATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSAIT 725
+ATD++ + + +V+ K S ++L+ I V+ M+ DLS T
Sbjct: 303 LATDMSKHMTLLADLKTMVETKKVTSS-----GVLLLDNYSDRIQVLRNMVHCADLSNPT 357
Query: 726 KPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVY 785
KP E+ Q + AEF++QGD ER PM D++ A + K QVGFID++ ++
Sbjct: 358 KPLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHPLW 415
Query: 786 KEFSRF-HEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKK 827
+ ++ H + +LD + +NR +W A +EE +
Sbjct: 416 ETWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESR 457
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 148 bits (373), Expect = 2e-35
Identities = 105/357 (29%), Positives = 186/357 (52%), Gaps = 20/357 (5%)
Query: 486 ELAEILQAELPDADKYEINKFHFSDL----PLTELELVKCGIQMYYELKVVDKFHIPQEA 541
E ++L EL D +K+ ++ F ++L PLT + ++ E ++ F IP +
Sbjct: 389 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT-----IFQERDLLKTFKIPVDT 443
Query: 542 LVRFMYSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600
L+ ++ +L Y + YHN H +V Q+ LL T L+ FTDLE LA + A+ HD
Sbjct: 444 LITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHD 503
Query: 601 IDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAI 659
+DH G +N + + + + LA ++ SS+LE HHL G LL++E+ +IFQNL ++Q +
Sbjct: 504 VDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLR 563
Query: 660 HMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTAC 719
M+ ++ATD++ + + +V+ K S ++L+ I + M C
Sbjct: 564 KMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS-----GVLLLDNYSDRIQVLQNMVHC 618
Query: 720 -DLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFID 778
DLS TKP ++ Q + EF+ QGD ER PM D++ A + K QVGFID
Sbjct: 619 ADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNA-SVEKSQVGFID 676
Query: 779 FVCTFVYKEFSRF-HEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAK 834
++ +++ ++ H + +LD + +NR+ +++ + + E+ ++ Q+ K
Sbjct: 677 YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEK 733
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 148 bits (373), Expect = 2e-35
Identities = 105/357 (29%), Positives = 186/357 (52%), Gaps = 20/357 (5%)
Query: 486 ELAEILQAELPDADKYEINKFHFSDL----PLTELELVKCGIQMYYELKVVDKFHIPQEA 541
E ++L EL D +K+ ++ F ++L PLT + ++ E ++ F IP +
Sbjct: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT-----IFQERDLLKTFKIPVDT 307
Query: 542 LVRFMYSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600
L+ ++ +L Y + YHN H +V Q+ LL T L+ FTDLE LA + A+ HD
Sbjct: 308 LITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHD 367
Query: 601 IDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAI 659
+DH G +N + + + + LA ++ SS+LE HHL G LL++E+ +IFQNL ++Q +
Sbjct: 368 VDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLR 427
Query: 660 HMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTAC 719
M+ ++ATD++ + + +V+ K S ++L+ I + M C
Sbjct: 428 KMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS-----GVLLLDNYSDRIQVLQNMVHC 482
Query: 720 -DLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFID 778
DLS TKP ++ Q + EF+ QGD ER PM D++ A + K QVGFID
Sbjct: 483 ADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNA-SVEKSQVGFID 540
Query: 779 FVCTFVYKEFSRF-HEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAK 834
++ +++ ++ H + +LD + +NR+ +++ + + E+ ++ Q+ K
Sbjct: 541 YIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEK 597
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 142 bits (359), Expect = 1e-33
Identities = 128/462 (27%), Positives = 222/462 (48%), Gaps = 40/462 (8%)
Query: 363 PAEDFFAFQK---EPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETL 419
PAED QK E LDE W + + ++ + E+ + + R + + ET
Sbjct: 91 PAED--TGQKLALETLDELDWCLDQLETLQTRHSVGEMA--SNKFKRILNRELTHLSETS 146
Query: 420 MES--LTQFLGWSVLNPDTYESMNKL--ENRKDIFQDIVKYHVKCDNEEIQKILKTREVY 475
+++++ + L+ T + K+ E I H C + + R +
Sbjct: 147 RSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR--F 204
Query: 476 GKEPWECEEEELAEILQAELPDADKYEINKFHFSDL----PLTELELVKCGIQMYYELKV 531
G + +EE+LA+ EL D +K+ ++ F ++L PLT + ++ E +
Sbjct: 205 GVQT--DQEEQLAK----ELEDTNKWGLDVFKVAELSGNRPLTAIIF-----SIFQERDL 253
Query: 532 VDKFHIPQEALVRFMYSLSKGYR-KITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEAL 590
+ F IP + L ++ L Y + YHN H +V Q+ LL T L+ FTDLE L
Sbjct: 254 LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL 313
Query: 591 AMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQN 649
A + A+ HD+DH G +N + + + + LA ++ +S+LE HHL G LL+ E+ +IFQN
Sbjct: 314 AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN 373
Query: 650 LNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKE 709
L+ +Q M+ ++ATD++ + + +V+ K ++L+
Sbjct: 374 LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTS-----LGVLLLDNYSDR 428
Query: 710 IVMAMMMTAC-DLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADE 768
I + + C DLS TKP + Q + AEF++QGD ER + PM D++ A
Sbjct: 429 IQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERE-SGLDISPMCDKHTA-S 486
Query: 769 LPKLQVGFIDFVCTFVYKEFSRF-HEEITPMLDGITNNRKEW 809
+ K QVGFID++ +++ ++ H + +LD + +NR EW
Sbjct: 487 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNR-EW 527
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 142 bits (359), Expect = 1e-33
Identities = 128/462 (27%), Positives = 222/462 (48%), Gaps = 40/462 (8%)
Query: 363 PAEDFFAFQK---EPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETL 419
PAED QK E LDE W + + ++ + E+ + + R + + ET
Sbjct: 165 PAED--TGQKLALETLDELDWCLDQLETLQTRHSVGEMA--SNKFKRILNRELTHLSETS 220
Query: 420 MES--LTQFLGWSVLNPDTYESMNKL--ENRKDIFQDIVKYHVKCDNEEIQKILKTREVY 475
+++++ + L+ T + K+ E I H C + + R +
Sbjct: 221 RSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR--F 278
Query: 476 GKEPWECEEEELAEILQAELPDADKYEINKFHFSDL----PLTELELVKCGIQMYYELKV 531
G + +EE+LA+ EL D +K+ ++ F ++L PLT + ++ E +
Sbjct: 279 GVQT--DQEEQLAK----ELEDTNKWGLDVFKVAELSGNRPLTAIIF-----SIFQERDL 327
Query: 532 VDKFHIPQEALVRFMYSLSKGYR-KITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEAL 590
+ F IP + L ++ L Y + YHN H +V Q+ LL T L+ FTDLE L
Sbjct: 328 LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL 387
Query: 591 AMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQN 649
A + A+ HD+DH G +N + + + + LA ++ +S+LE HHL G LL+ E+ +IFQN
Sbjct: 388 AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN 447
Query: 650 LNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKE 709
L+ +Q M+ ++ATD++ + + +V+ K ++L+
Sbjct: 448 LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTS-----LGVLLLDNYSDR 502
Query: 710 IVMAMMMTAC-DLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADE 768
I + + C DLS TKP + Q + AEF++QGD ER + PM D++ A
Sbjct: 503 IQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERE-SGLDISPMCDKHTA-S 560
Query: 769 LPKLQVGFIDFVCTFVYKEFSRF-HEEITPMLDGITNNRKEW 809
+ K QVGFID++ +++ ++ H + +LD + +NR EW
Sbjct: 561 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNR-EW 601
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 142 bits (359), Expect = 1e-33
Identities = 128/462 (27%), Positives = 222/462 (48%), Gaps = 40/462 (8%)
Query: 363 PAEDFFAFQK---EPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETL 419
PAED QK E LDE W + + ++ + E+ + + R + + ET
Sbjct: 197 PAED--TGQKLALETLDELDWCLDQLETLQTRHSVGEMA--SNKFKRILNRELTHLSETS 252
Query: 420 MES--LTQFLGWSVLNPDTYESMNKL--ENRKDIFQDIVKYHVKCDNEEIQKILKTREVY 475
+++++ + L+ T + K+ E I H C + + R +
Sbjct: 253 RSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR--F 310
Query: 476 GKEPWECEEEELAEILQAELPDADKYEINKFHFSDL----PLTELELVKCGIQMYYELKV 531
G + +EE+LA+ EL D +K+ ++ F ++L PLT + ++ E +
Sbjct: 311 GVQT--DQEEQLAK----ELEDTNKWGLDVFKVAELSGNRPLTAIIF-----SIFQERDL 359
Query: 532 VDKFHIPQEALVRFMYSLSKGYR-KITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEAL 590
+ F IP + L ++ L Y + YHN H +V Q+ LL T L+ FTDLE L
Sbjct: 360 LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL 419
Query: 591 AMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQN 649
A + A+ HD+DH G +N + + + + LA ++ +S+LE HHL G LL+ E+ +IFQN
Sbjct: 420 AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN 479
Query: 650 LNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKE 709
L+ +Q M+ ++ATD++ + + +V+ K ++L+
Sbjct: 480 LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTS-----LGVLLLDNYSDR 534
Query: 710 IVMAMMMTAC-DLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADE 768
I + + C DLS TKP + Q + AEF++QGD ER + PM D++ A
Sbjct: 535 IQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERE-SGLDISPMCDKHTA-S 592
Query: 769 LPKLQVGFIDFVCTFVYKEFSRF-HEEITPMLDGITNNRKEW 809
+ K QVGFID++ +++ ++ H + +LD + +NR EW
Sbjct: 593 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNR-EW 633
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 133 bits (335), Expect = 6e-31
Identities = 98/330 (29%), Positives = 168/330 (50%), Gaps = 20/330 (6%)
Query: 491 LQAELPDADKYEINKFHFS----DLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFM 546
L EL D +K+ +N F+ + + PLT + ++ E ++ F I + + +M
Sbjct: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYA-----IFQERDLLKTFRISSDTFITYM 392
Query: 547 YSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRG 605
+L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
Query: 606 TNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDI 664
+N + + + + LA ++ S+LE HHL G LL++E +IF NL ++Q + M+
Sbjct: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
Query: 665 AIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSA 723
++ATD++ + + +V+ K S ++L+ I V+ M+ DLS
Sbjct: 513 MVLATDMSKHMSLLADLKTMVETKKVTSS-----GVLLLDNYTDRIQVLRNMVHCADLSN 567
Query: 724 ITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTF 783
TK E+ Q + EF++QGD ER PM D++ A + K QVGFID++
Sbjct: 568 PTKSLELYRQWTDRIMEEFFQQGDKERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHP 625
Query: 784 VYKEFSRF-HEEITPMLDGITNNRKEWKAL 812
+++ ++ + +LD + +NR ++++
Sbjct: 626 LWETWADLVQPDAQDILDTLEDNRNWYQSM 655
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 133 bits (335), Expect = 6e-31
Identities = 98/330 (29%), Positives = 168/330 (50%), Gaps = 20/330 (6%)
Query: 491 LQAELPDADKYEINKFHFS----DLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFM 546
L EL D +K+ +N F+ + + PLT + ++ E ++ F I + + +M
Sbjct: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYA-----IFQERDLLKTFRISSDTFITYM 377
Query: 547 YSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRG 605
+L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G
Sbjct: 378 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 437
Query: 606 TNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDI 664
+N + + + + LA ++ S+LE HHL G LL++E +IF NL ++Q + M+
Sbjct: 438 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 497
Query: 665 AIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSA 723
++ATD++ + + +V+ K S ++L+ I V+ M+ DLS
Sbjct: 498 MVLATDMSKHMSLLADLKTMVETKKVTSS-----GVLLLDNYTDRIQVLRNMVHCADLSN 552
Query: 724 ITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTF 783
TK E+ Q + EF++QGD ER PM D++ A + K QVGFID++
Sbjct: 553 PTKSLELYRQWTDRIMEEFFQQGDKERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHP 610
Query: 784 VYKEFSRF-HEEITPMLDGITNNRKEWKAL 812
+++ ++ + +LD + +NR ++++
Sbjct: 611 LWETWADLVQPDAQDILDTLEDNRNWYQSM 640
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 133 bits (335), Expect = 6e-31
Identities = 98/330 (29%), Positives = 168/330 (50%), Gaps = 20/330 (6%)
Query: 491 LQAELPDADKYEINKFHFS----DLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFM 546
L EL D +K+ +N F+ + + PLT + ++ E ++ F I + + +M
Sbjct: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYA-----IFQERDLLKTFRISSDTFITYM 220
Query: 547 YSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRG 605
+L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G
Sbjct: 221 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 280
Query: 606 TNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDI 664
+N + + + + LA ++ S+LE HHL G LL++E +IF NL ++Q + M+
Sbjct: 281 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 340
Query: 665 AIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSA 723
++ATD++ + + +V+ K S ++L+ I V+ M+ DLS
Sbjct: 341 MVLATDMSKHMSLLADLKTMVETKKVTSS-----GVLLLDNYTDRIQVLRNMVHCADLSN 395
Query: 724 ITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTF 783
TK E+ Q + EF++QGD ER PM D++ A + K QVGFID++
Sbjct: 396 PTKSLELYRQWTDRIMEEFFQQGDKERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHP 453
Query: 784 VYKEFSRF-HEEITPMLDGITNNRKEWKAL 812
+++ ++ + +LD + +NR ++++
Sbjct: 454 LWETWADLVQPDAQDILDTLEDNRNWYQSM 483
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 133 bits (335), Expect = 6e-31
Identities = 98/330 (29%), Positives = 168/330 (50%), Gaps = 20/330 (6%)
Query: 491 LQAELPDADKYEINKFHFS----DLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFM 546
L EL D +K+ +N F+ + + PLT + ++ E ++ F I + + +M
Sbjct: 338 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYA-----IFQERDLLKTFRISSDTFITYM 392
Query: 547 YSLSKGYRK-ITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRG 605
+L Y + YHN H +V Q+ LL T L FTDLE LA + AA HD+DH G
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
Query: 606 TNNLYQMKSQNPLAKLHG-SSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDI 664
+N + + + + LA ++ S+LE HHL G LL++E +IF NL ++Q + M+
Sbjct: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
Query: 665 AIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEI-VMAMMMTACDLSA 723
++ATD++ + + +V+ K S ++L+ I V+ M+ DLS
Sbjct: 513 MVLATDMSKHMSLLADLKTMVETKKVTSS-----GVLLLDNYTDRIQVLRNMVHCADLSN 567
Query: 724 ITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTF 783
TK E+ Q + EF++QGD ER PM D++ A + K QVGFID++
Sbjct: 568 PTKSLELYRQWTDRIMEEFFQQGDKERE-RGMEISPMCDKHTA-SVEKSQVGFIDYIVHP 625
Query: 784 VYKEFSRF-HEEITPMLDGITNNRKEWKAL 812
+++ ++ + +LD + +NR ++++
Sbjct: 626 LWETWADLVQPDAQDILDTLEDNRNWYQSM 655
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,136,164
Number of Sequences: 37866
Number of extensions: 1462041
Number of successful extensions: 5144
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 4854
Number of HSP's gapped (non-prelim): 123
length of query: 860
length of database: 18,247,518
effective HSP length: 111
effective length of query: 749
effective length of database: 14,044,392
effective search space: 10519249608
effective search space used: 10519249608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.