Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 169403957

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens]
         (343 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens]        708   0.0  
gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens]        618   e-177
gi|70995241 ankyrin repeat domain 10 [Homo sapiens]                    87   3e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        77   2e-14
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         77   2e-14
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         77   2e-14
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         77   2e-14
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         77   2e-14
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]         75   7e-14
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]         75   7e-14
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]         75   7e-14
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]         75   7e-14
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]         75   7e-14
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]         75   7e-14
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        74   1e-13
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         74   1e-13
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         74   1e-13
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         72   6e-13
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                    69   6e-12
gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens]    69   6e-12
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof...    69   8e-12
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   68   1e-11
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    67   3e-11
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi...    65   9e-11
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]           64   2e-10
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]         64   2e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    64   3e-10
gi|110431370 espin [Homo sapiens]                                      63   3e-10
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...    63   4e-10
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...    63   4e-10

>gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens]
          Length = 343

 Score =  708 bits (1828), Expect = 0.0
 Identities = 343/343 (100%), Positives = 343/343 (100%)

Query: 1   MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60
           MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL
Sbjct: 1   MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60

Query: 61  PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120
           PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV
Sbjct: 61  PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120

Query: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180
           EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL
Sbjct: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180

Query: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240
           VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ
Sbjct: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240

Query: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300
           DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY
Sbjct: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300

Query: 301 QGQGCSVHFPFAFSPITPETLLWQDISLLSDCGFLWRRRELSF 343
           QGQGCSVHFPFAFSPITPETLLWQDISLLSDCGFLWRRRELSF
Sbjct: 301 QGQGCSVHFPFAFSPITPETLLWQDISLLSDCGFLWRRRELSF 343


>gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens]
          Length = 530

 Score =  618 bits (1594), Expect = e-177
 Identities = 301/301 (100%), Positives = 301/301 (100%)

Query: 1   MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60
           MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL
Sbjct: 1   MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL 60

Query: 61  PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120
           PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV
Sbjct: 61  PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV 120

Query: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180
           EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL
Sbjct: 121 EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL 180

Query: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240
           VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ
Sbjct: 181 VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240

Query: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300
           DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY
Sbjct: 241 DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY 300

Query: 301 Q 301
           Q
Sbjct: 301 Q 301


>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
          Length = 420

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 45/124 (36%), Positives = 68/124 (54%), Gaps = 4/124 (3%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G+T +H+AA +GKL CL  LV          T  +QTP H+     +      C+ +L++
Sbjct: 58  GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQ----CLVWLIQ 113

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
            GA++N   C G TP+H AAR G L+C+  LV +GA+V  ++A G    D  +    + C
Sbjct: 114 AGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQEC 173

Query: 260 ARFL 263
           A+FL
Sbjct: 174 AQFL 177


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+VE +   L +   +     KGFT +H AA++GK+   ++L+E    P +    N
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 601

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+ +H +N    L  +  LL +G   ++   NG TPLH+AA+   ++  + L+Q 
Sbjct: 602 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 657

Query: 234 GANVHAQDAMGYKPI 248
           G + +A+   G  P+
Sbjct: 658 GGSANAESVQGVTPL 672



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V      L+           G + IH AAQ   L C+++L++ Y   +D +T +
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 370

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  +  VA      LL+KGA  N++  NG TPLH+A +   +  +++L+++
Sbjct: 371 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  P+       H
Sbjct: 427 GASIDAVTESGLTPLHVASFMGH 449



 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ E +   L++       +  G T +H  AQ G +    VL++ +   VD  T  
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 733

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  N    +  + +LL+  AD+NA+T  G +PLH AA+ G  D V +L+++
Sbjct: 734 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA+ +   + G  P+   K
Sbjct: 790 GASPNEVSSDGTTPLAIAK 808



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           GFT +H AA +  L   Q+L+      V+    N  TPLH+   R N  +    +  LL+
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 293

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
           +GA +  +T +  TPLH AAR+G +   ++L+  GA + A+   G  PI      +H  C
Sbjct: 294 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 353

Query: 260 ARFL 263
            R L
Sbjct: 354 VRLL 357



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)

Query: 89  DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
           DP+P   S +T      I ++Y+       N+   +  LN+      T   G T +H A+
Sbjct: 229 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 280

Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
           + G +  +++L++     ++  T +  TPLH      +  ++      LL+ GA + A+T
Sbjct: 281 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 335

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
            NG +P+H+AA+   LDCV++L+Q  A +         P+       H   A+ L D
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+   ++  L  +         G T +H AA+ G +  +  L+E+       +T  
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 568

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+        VA      LLE+ A  NA   NG TPLH+A     LD VK+L+  
Sbjct: 569 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 624

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           G + H+    GY P+      N    AR L
Sbjct: 625 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)

Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
           + G T +H A+  G L  ++ L++    P ++     +TPLH+     +T VA     YL
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 489

Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
           L+  A +NA+  +  TPLH AAR G  + VK+L+++ AN +     G+ P+
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA    VE  R  L           +G T +H AAQ G    + +L+ + +   +L   +
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 700

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLHLV    +  VA      L++ G  ++A T  G TPLH+A+  G +  VK L+Q 
Sbjct: 701 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756

Query: 234 GANVHAQDAMGYKPI 248
            A+V+A+  +GY P+
Sbjct: 757 QADVNAKTKLGYSPL 771



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++     L   +     +  G   +H A++ G +  +  L+ + +  ++  T
Sbjct: 50  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 108

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    + Y    GA++NAQ+  G TPL++AA++  L+ VK L+
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN +     G+ P+
Sbjct: 165 ENGANQNVATEDGFTPL 181



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
           ++    N    LHL     +  + +     LL K   L   T  G+T LH+AA  G  + 
Sbjct: 71  INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 126

Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           V+ LV  GANV+AQ   G+ P+      NH    +FL
Sbjct: 127 VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+V+ +   L++ +    T  KG TA+H AA  G+   ++ LV  Y   V+  +  
Sbjct: 85  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 143

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + +LLE GA+ N  T +G TPL +A + G  + V  L+  
Sbjct: 144 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199

Query: 234 G 234
           G
Sbjct: 200 G 200



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G  E +R  +N          KGFT ++ AAQ   L  ++ L+E      ++ T +
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 176

Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
             TPL             HL+ +     V LP ++             LL+   + +  +
Sbjct: 177 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 236

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
             G TPLH+AA    L+  ++L+  GA+V+     G  P+       +    R L D
Sbjct: 237 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 293


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+VE +   L +   +     KGFT +H AA++GK+   ++L+E    P +    N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+ +H +N    L  +  LL +G   ++   NG TPLH+AA+   ++  + L+Q 
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 234 GANVHAQDAMGYKPI 248
           G + +A+   G  P+
Sbjct: 625 GGSANAESVQGVTPL 639



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V      L+           G + IH AAQ   L C+++L++ Y   +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  +  VA      LL+KGA  N++  NG TPLH+A +   +  +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  P+       H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416



 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ E +   L++       +  G T +H  AQ G +    VL++ +   VD  T  
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  N    +  + +LL+  AD+NA+T  G +PLH AA+ G  D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA+ +   + G  P+   K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           GFT +H AA +  L   Q+L+      V+    N  TPLH+   R N  +    +  LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
           +GA +  +T +  TPLH AAR+G +   ++L+  GA + A+   G  PI      +H  C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 260 ARFL 263
            R L
Sbjct: 321 VRLL 324



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)

Query: 89  DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
           DP+P   S +T      I ++Y+       N+   +  LN+      T   G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
           + G +  +++L++     ++  T +  TPLH      +  ++      LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
            NG +P+H+AA+   LDCV++L+Q  A +         P+       H   A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+   ++  L  +         G T +H AA+ G +  +  L+E+       +T  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+        VA      LLE+ A  NA   NG TPLH+A     LD VK+L+  
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           G + H+    GY P+      N    AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)

Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
           + G T +H A+  G L  ++ L++    P ++     +TPLH+     +T VA     YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456

Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
           L+  A +NA+  +  TPLH AAR G  + VK+L+++ AN +     G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA    VE  R  L           +G T +H AAQ G    + +L+ + +   +L   +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLHLV    +  VA      L++ G  ++A T  G TPLH+A+  G +  VK L+Q 
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 234 GANVHAQDAMGYKPI 248
            A+V+A+  +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++     L   +     +  G   +H A++ G +  +  L+ + +  ++  T
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    + Y    GA++NAQ+  G TPL++AA++  L+ VK L+
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN +     G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
           ++    N    LHL     +  + +     LL K   L   T  G+T LH+AA  G  + 
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           V+ LV  GANV+AQ   G+ P+      NH    +FL
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+V+ +   L++ +    T  KG TA+H AA  G+   ++ LV  Y   V+  +  
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + +LLE GA+ N  T +G TPL +A + G  + V  L+  
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 234 G 234
           G
Sbjct: 167 G 167



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G  E +R  +N          KGFT ++ AAQ   L  ++ L+E      ++ T +
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143

Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
             TPL             HL+ +     V LP ++             LL+   + +  +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
             G TPLH+AA    L+  ++L+  GA+V+     G  P+       +    R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+VE +   L +   +     KGFT +H AA++GK+   ++L+E    P +    N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+ +H +N    L  +  LL +G   ++   NG TPLH+AA+   ++  + L+Q 
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 234 GANVHAQDAMGYKPI 248
           G + +A+   G  P+
Sbjct: 625 GGSANAESVQGVTPL 639



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V      L+           G + IH AAQ   L C+++L++ Y   +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  +  VA      LL+KGA  N++  NG TPLH+A +   +  +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  P+       H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416



 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ E +   L++       +  G T +H  AQ G +    VL++ +   VD  T  
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  N    +  + +LL+  AD+NA+T  G +PLH AA+ G  D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA+ +   + G  P+   K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           GFT +H AA +  L   Q+L+      V+    N  TPLH+   R N  +    +  LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
           +GA +  +T +  TPLH AAR+G +   ++L+  GA + A+   G  PI      +H  C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 260 ARFL 263
            R L
Sbjct: 321 VRLL 324



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)

Query: 89  DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
           DP+P   S +T      I ++Y+       N+   +  LN+      T   G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
           + G +  +++L++     ++  T +  TPLH      +  ++      LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
            NG +P+H+AA+   LDCV++L+Q  A +         P+       H   A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+   ++  L  +         G T +H AA+ G +  +  L+E+       +T  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+        VA      LLE+ A  NA   NG TPLH+A     LD VK+L+  
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           G + H+    GY P+      N    AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)

Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
           + G T +H A+  G L  ++ L++    P ++     +TPLH+     +T VA     YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456

Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
           L+  A +NA+  +  TPLH AAR G  + VK+L+++ AN +     G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA    VE  R  L           +G T +H AAQ G    + +L+ + +   +L   +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLHLV    +  VA      L++ G  ++A T  G TPLH+A+  G +  VK L+Q 
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 234 GANVHAQDAMGYKPI 248
            A+V+A+  +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++     L   +     +  G   +H A++ G +  +  L+ + +  ++  T
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    + Y    GA++NAQ+  G TPL++AA++  L+ VK L+
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN +     G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
           ++    N    LHL     +  + +     LL K   L   T  G+T LH+AA  G  + 
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           V+ LV  GANV+AQ   G+ P+      NH    +FL
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+V+ +   L++ +    T  KG TA+H AA  G+   ++ LV  Y   V+  +  
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + +LLE GA+ N  T +G TPL +A + G  + V  L+  
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 234 G 234
           G
Sbjct: 167 G 167



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G  E +R  +N          KGFT ++ AAQ   L  ++ L+E      ++ T +
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143

Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
             TPL             HL+ +     V LP ++             LL+   + +  +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
             G TPLH+AA    L+  ++L+  GA+V+     G  P+       +    R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+VE +   L +   +     KGFT +H AA++GK+   ++L+E    P +    N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+ +H +N    L  +  LL +G   ++   NG TPLH+AA+   ++  + L+Q 
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 234 GANVHAQDAMGYKPI 248
           G + +A+   G  P+
Sbjct: 625 GGSANAESVQGVTPL 639



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V      L+           G + IH AAQ   L C+++L++ Y   +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  +  VA      LL+KGA  N++  NG TPLH+A +   +  +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  P+       H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416



 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ E +   L++       +  G T +H  AQ G +    VL++ +   VD  T  
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  N    +  + +LL+  AD+NA+T  G +PLH AA+ G  D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA+ +   + G  P+   K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           GFT +H AA +  L   Q+L+      V+    N  TPLH+   R N  +    +  LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
           +GA +  +T +  TPLH AAR+G +   ++L+  GA + A+   G  PI      +H  C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 260 ARFL 263
            R L
Sbjct: 321 VRLL 324



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)

Query: 89  DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
           DP+P   S +T      I ++Y+       N+   +  LN+      T   G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
           + G +  +++L++     ++  T +  TPLH      +  ++      LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
            NG +P+H+AA+   LDCV++L+Q  A +         P+       H   A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+   ++  L  +         G T +H AA+ G +  +  L+E+       +T  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+        VA      LLE+ A  NA   NG TPLH+A     LD VK+L+  
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           G + H+    GY P+      N    AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)

Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
           + G T +H A+  G L  ++ L++    P ++     +TPLH+     +T VA     YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456

Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
           L+  A +NA+  +  TPLH AAR G  + VK+L+++ AN +     G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA    VE  R  L           +G T +H AAQ G    + +L+ + +   +L   +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLHLV    +  VA      L++ G  ++A T  G TPLH+A+  G +  VK L+Q 
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 234 GANVHAQDAMGYKPI 248
            A+V+A+  +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++     L   +     +  G   +H A++ G +  +  L+ + +  ++  T
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    + Y    GA++NAQ+  G TPL++AA++  L+ VK L+
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN +     G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
           ++    N    LHL     +  + +     LL K   L   T  G+T LH+AA  G  + 
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           V+ LV  GANV+AQ   G+ P+      NH    +FL
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+V+ +   L++ +    T  KG TA+H AA  G+   ++ LV  Y   V+  +  
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + +LLE GA+ N  T +G TPL +A + G  + V  L+  
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 234 G 234
           G
Sbjct: 167 G 167



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G  E +R  +N          KGFT ++ AAQ   L  ++ L+E      ++ T +
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143

Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
             TPL             HL+ +     V LP ++             LL+   + +  +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
             G TPLH+AA    L+  ++L+  GA+V+     G  P+       +    R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 43/135 (31%), Positives = 72/135 (53%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+VE +   L +   +     KGFT +H AA++GK+   ++L+E    P +    N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKN 568

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+ +H +N    L  +  LL +G   ++   NG TPLH+AA+   ++  + L+Q 
Sbjct: 569 GLTPLHVAVHHNN----LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQY 624

Query: 234 GANVHAQDAMGYKPI 248
           G + +A+   G  P+
Sbjct: 625 GGSANAESVQGVTPL 639



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V      L+           G + IH AAQ   L C+++L++ Y   +D +T +
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ-YDAEIDDITLD 337

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  +  VA      LL+KGA  N++  NG TPLH+A +   +  +++L+++
Sbjct: 338 HLTPLHVAAHCGHHRVAK----VLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  P+       H
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416



 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 44/139 (31%), Positives = 71/139 (51%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ E +   L++       +  G T +H  AQ G +    VL++ +   VD  T  
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRM 700

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H  N    +  + +LL+  AD+NA+T  G +PLH AA+ G  D V +L+++
Sbjct: 701 GYTPLHVASHYGN----IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA+ +   + G  P+   K
Sbjct: 757 GASPNEVSSDGTTPLAIAK 775



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 5/124 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           GFT +H AA +  L   Q+L+      V+    N  TPLH+   R N  +    +  LL+
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGA-SVNFTPQNGITPLHIASRRGNVIM----VRLLLD 260

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
           +GA +  +T +  TPLH AAR+G +   ++L+  GA + A+   G  PI      +H  C
Sbjct: 261 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDC 320

Query: 260 ARFL 263
            R L
Sbjct: 321 VRLL 324



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 46/177 (25%), Positives = 82/177 (46%), Gaps = 13/177 (7%)

Query: 89  DPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAA 148
           DP+P   S +T      I ++Y+       N+   +  LN+      T   G T +H A+
Sbjct: 196 DPNPDVLS-KTGFTPLHIAAHYE-------NLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 149 QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQT 208
           + G +  +++L++     ++  T +  TPLH      +  ++      LL+ GA + A+T
Sbjct: 248 RRGNVIMVRLLLDRGA-QIETKTKDELTPLHCAARNGHVRIS----EILLDHGAPIQAKT 302

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
            NG +P+H+AA+   LDCV++L+Q  A +         P+       H   A+ L D
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 46/150 (30%), Positives = 66/150 (44%), Gaps = 5/150 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+   ++  L  +         G T +H AA+ G +  +  L+E+       +T  
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA-CMTKK 535

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+        VA      LLE+ A  NA   NG TPLH+A     LD VK+L+  
Sbjct: 536 GFTPLHVAAKYGKVRVA----ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           G + H+    GY P+      N    AR L
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 5/111 (4%)

Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
           + G T +H A+  G L  ++ L++    P ++     +TPLH+     +T VA     YL
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASP-NVSNVKVETPLHMAARAGHTEVAK----YL 456

Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
           L+  A +NA+  +  TPLH AAR G  + VK+L+++ AN +     G+ P+
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA    VE  R  L           +G T +H AAQ G    + +L+ + +   +L   +
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK-QANGNLGNKS 667

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLHLV    +  VA      L++ G  ++A T  G TPLH+A+  G +  VK L+Q 
Sbjct: 668 GLTPLHLVAQEGHVPVA----DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 234 GANVHAQDAMGYKPI 248
            A+V+A+  +GY P+
Sbjct: 724 QADVNAKTKLGYSPL 738



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 37/137 (27%), Positives = 67/137 (48%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++     L   +     +  G   +H A++ G +  +  L+ + +  ++  T
Sbjct: 17  LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTT 75

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    + Y    GA++NAQ+  G TPL++AA++  L+ VK L+
Sbjct: 76  KKGNTALHIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN +     G+ P+
Sbjct: 132 ENGANQNVATEDGFTPL 148



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 4/97 (4%)

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
           ++    N    LHL     +  + +     LL K   L   T  G+T LH+AA  G  + 
Sbjct: 38  INTCNQNGLNGLHLASKEGHVKMVVE----LLHKEIILETTTKKGNTALHIAALAGQDEV 93

Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           V+ LV  GANV+AQ   G+ P+      NH    +FL
Sbjct: 94  VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 5/121 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+V+ +   L++ +    T  KG TA+H AA  G+   ++ LV  Y   V+  +  
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + +LLE GA+ N  T +G TPL +A + G  + V  L+  
Sbjct: 111 GFTPLYMAAQENHLEV----VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166

Query: 234 G 234
           G
Sbjct: 167 G 167



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 44/177 (24%), Positives = 71/177 (40%), Gaps = 26/177 (14%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G  E +R  +N          KGFT ++ AAQ   L  ++ L+E      ++ T +
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ-NVATED 143

Query: 174 SQTPL-------------HLVIHRDNTTVALPCIYY------------LLEKGADLNAQT 208
             TPL             HL+ +     V LP ++             LL+   + +  +
Sbjct: 144 GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 203

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
             G TPLH+AA    L+  ++L+  GA+V+     G  P+       +    R L D
Sbjct: 204 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260


>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
          Length = 983

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)

Query: 97  DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
           D TA D T   + +   AA   + E +R  L         D  G TA+H+AA  G L  +
Sbjct: 81  DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 138

Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
           Q+L E +K P++L   +   PL L +   ++ +     ++LL+ GAD+N++  +G T L 
Sbjct: 139 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 193

Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
           LA   G  + V+ L++ GA+++  D++GY  + + K+
Sbjct: 194 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 230



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +G TA H AA  G + CL+V++      VD+   +  T  H  +H         CI  
Sbjct: 53  DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 107

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL+      +   +G T LH AA  G L  V++L +  + ++ +D  G  P+       H
Sbjct: 108 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 167

Query: 257 RACARFLKD 265
                FL D
Sbjct: 168 SEICHFLLD 176



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/65 (33%), Positives = 33/65 (50%)

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           +KGA        G T  HLAA  G ++C++V++  G +V AQD  G+  +      +H  
Sbjct: 44  KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 103

Query: 259 CARFL 263
           C R L
Sbjct: 104 CIRKL 108


>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
          Length = 972

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)

Query: 97  DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
           D TA D T   + +   AA   + E +R  L         D  G TA+H+AA  G L  +
Sbjct: 70  DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 127

Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
           Q+L E +K P++L   +   PL L +   ++ +     ++LL+ GAD+N++  +G T L 
Sbjct: 128 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 182

Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
           LA   G  + V+ L++ GA+++  D++GY  + + K+
Sbjct: 183 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 219



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +G TA H AA  G + CL+V++      VD+   +  T  H  +H         CI  
Sbjct: 42  DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 96

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL+      +   +G T LH AA  G L  V++L +  + ++ +D  G  P+       H
Sbjct: 97  LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 156

Query: 257 RACARFLKD 265
                FL D
Sbjct: 157 SEICHFLLD 165



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/65 (33%), Positives = 33/65 (50%)

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           +KGA        G T  HLAA  G ++C++V++  G +V AQD  G+  +      +H  
Sbjct: 33  KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 92

Query: 259 CARFL 263
           C R L
Sbjct: 93  CIRKL 97


>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
          Length = 951

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)

Query: 97  DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
           D TA D T   + +   AA   + E +R  L         D  G TA+H+AA  G L  +
Sbjct: 78  DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135

Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
           Q+L E +K P++L   +   PL L +   ++ +     ++LL+ GAD+N++  +G T L 
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190

Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
           LA   G  + V+ L++ GA+++  D++GY  + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +G TA H AA  G + CL+V++      VD+   +  T  H  +H         CI  
Sbjct: 50  DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL+      +   +G T LH AA  G L  V++L +  + ++ +D  G  P+       H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164

Query: 257 RACARFLKD 265
                FL D
Sbjct: 165 SEICHFLLD 173



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/65 (33%), Positives = 33/65 (50%)

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           +KGA        G T  HLAA  G ++C++V++  G +V AQD  G+  +      +H  
Sbjct: 41  KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100

Query: 259 CARFL 263
           C R L
Sbjct: 101 CIRKL 105


>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)

Query: 97  DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
           D TA D T   + +   AA   + E +R  L         D  G TA+H+AA  G L  +
Sbjct: 78  DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135

Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
           Q+L E +K P++L   +   PL L +   ++ +     ++LL+ GAD+N++  +G T L 
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190

Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
           LA   G  + V+ L++ GA+++  D++GY  + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +G TA H AA  G + CL+V++      VD+   +  T  H  +H         CI  
Sbjct: 50  DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL+      +   +G T LH AA  G L  V++L +  + ++ +D  G  P+       H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164

Query: 257 RACARFLKD 265
                FL D
Sbjct: 165 SEICHFLLD 173



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/65 (33%), Positives = 33/65 (50%)

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           +KGA        G T  HLAA  G ++C++V++  G +V AQD  G+  +      +H  
Sbjct: 41  KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100

Query: 259 CARFL 263
           C R L
Sbjct: 101 CIRKL 105


>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)

Query: 97  DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
           D TA D T   + +   AA   + E +R  L         D  G TA+H+AA  G L  +
Sbjct: 78  DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135

Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
           Q+L E +K P++L   +   PL L +   ++ +     ++LL+ GAD+N++  +G T L 
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190

Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
           LA   G  + V+ L++ GA+++  D++GY  + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +G TA H AA  G + CL+V++      VD+   +  T  H  +H         CI  
Sbjct: 50  DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL+      +   +G T LH AA  G L  V++L +  + ++ +D  G  P+       H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164

Query: 257 RACARFLKD 265
                FL D
Sbjct: 165 SEICHFLLD 173



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/65 (33%), Positives = 33/65 (50%)

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           +KGA        G T  HLAA  G ++C++V++  G +V AQD  G+  +      +H  
Sbjct: 41  KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100

Query: 259 CARFL 263
           C R L
Sbjct: 101 CIRKL 105


>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
          Length = 980

 Score = 75.5 bits (184), Expect = 7e-14
 Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 7/157 (4%)

Query: 97  DQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACL 156
           D TA D T   + +   AA   + E +R  L         D  G TA+H+AA  G L  +
Sbjct: 78  DVTAQDTTGHSALH--LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135

Query: 157 QVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLH 216
           Q+L E +K P++L   +   PL L +   ++ +     ++LL+ GAD+N++  +G T L 
Sbjct: 136 QILCE-HKSPINLKDLDGNIPLLLAVQNGHSEIC----HFLLDHGADVNSRNKSGRTALM 190

Query: 217 LAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKI 253
           LA   G  + V+ L++ GA+++  D++GY  + + K+
Sbjct: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +G TA H AA  G + CL+V++      VD+   +  T  H  +H         CI  
Sbjct: 50  DSEGKTAFHLAAAKGHVECLRVMITH---GVDVTAQD--TTGHSALHLAAKNSHHECIRK 104

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL+      +   +G T LH AA  G L  V++L +  + ++ +D  G  P+       H
Sbjct: 105 LLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGH 164

Query: 257 RACARFLKD 265
                FL D
Sbjct: 165 SEICHFLLD 173



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 22/65 (33%), Positives = 33/65 (50%)

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           +KGA        G T  HLAA  G ++C++V++  G +V AQD  G+  +      +H  
Sbjct: 41  KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100

Query: 259 CARFL 263
           C R L
Sbjct: 101 CIRKL 105


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 5/152 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           +A  G V+     L           KGFT +H AA++G L   ++L++  +   D    N
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKN 574

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H DN  VAL     LLEKGA  +A   NG TPLH+AA+   +     L+  
Sbjct: 575 GLTPLHVAAHYDNQKVAL----LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
           GA  +     G  P+       H      L D
Sbjct: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 43/128 (33%), Positives = 67/128 (52%), Gaps = 5/128 (3%)

Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
           T + GFT +H AA +G +    +L+      VD    N  TPLH+   R NT +    + 
Sbjct: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNM----VK 262

Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
            LL++G  ++A+T +G TPLH AAR G    V++L++ GA + A+   G  P+      +
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 322

Query: 256 HRACARFL 263
           H  C + L
Sbjct: 323 HVECVKHL 330



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G++  +   L        T+ +G TA+H AA+ G++  ++ L+      VD     
Sbjct: 417 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARARE 475

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
            QTPLH+      T +    +  LL+  A  +A T NG TPLH++AR+G +D   VL+++
Sbjct: 476 EQTPLHIASRLGKTEI----VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 531

Query: 234 GANVHAQDAMGYKPI 248
           GA        G+ P+
Sbjct: 532 GAAHSLATKKGFTPL 546



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 43/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ + +   L +    +     G + +H AAQ   + C++ L++ +K PVD +T +
Sbjct: 285 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-HKAPVDDVTLD 343

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             T LH+  H  +  V       LL+K A+ NA+  NG TPLH+A +   +  +++LV+ 
Sbjct: 344 YLTALHVAAHCGHYRVTK----LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 399

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  PI       H
Sbjct: 400 GASIQAITESGLTPIHVAAFMGH 422



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 43/137 (31%), Positives = 71/137 (51%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++ +   L   +     +  G  A+H AA+ G +  +Q L+      VD  T
Sbjct: 15  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSAT 73

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    +  L+++GA++NAQ+ NG TPL++AA++  +D VK L+
Sbjct: 74  KKGNTALHIASLAGQAEV----VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 129

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN       G+ P+
Sbjct: 130 ENGANQSTATEDGFTPL 146



 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+ + +   L++      +   G T++H AAQ  K+    +L + +    D  T  
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK-HGADQDAHTKL 706

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL +  H  N  +    + +LL++GA++NA+T NG TPLH AA+ G    + VL+Q 
Sbjct: 707 GYTPLIVACHYGNVKM----VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA  +A  A G   +   K
Sbjct: 763 GAKPNATTANGNTALAIAK 781



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 6/110 (5%)

Query: 156 LQVLVEEYKFPVDLLT--NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGST 213
           L  +VE  K  +D+ T   N    LHL     +  +    +  LL +G+ +++ T  G+T
Sbjct: 23  LDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL----VQELLGRGSSVDSATKKGNT 78

Query: 214 PLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
            LH+A+  G  + VKVLV+ GAN++AQ   G+ P+      NH    ++L
Sbjct: 79  ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 36/120 (30%), Positives = 63/120 (52%), Gaps = 5/120 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V  ++  L +         KG TA+H A+  G+   ++VLV+E    ++  + N
Sbjct: 50  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQN 108

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + YLLE GA+ +  T +G TPL +A + G    V +L+++
Sbjct: 109 GFTPLYMAAQENHIDV----VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 164



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 11/134 (8%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGF---TAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
           AA   +VE ++  L     + P DD      TA+H AA  G     ++L+++   P +  
Sbjct: 318 AAQGDHVECVKHLLQH---KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP-NAR 373

Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
             N  TPLH+   ++   V    +  L++ GA + A T +G TP+H+AA  G L+ V +L
Sbjct: 374 ALNGFTPLHIACKKNRIKV----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429

Query: 231 VQSGANVHAQDAMG 244
           +Q+GA+    +  G
Sbjct: 430 LQNGASPDVTNIRG 443



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G+T +  A  +G +  +  L+++    V+  T N  TPLH    + +T +    I  LL+
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHI----INVLLQ 761

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
            GA  NA T NG+T L +A R G +  V  L
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 13/166 (7%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA   +++ +++ L     +    + GFT +  A Q G    + +L+E      D     
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKV 170

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADL------NAQTCNGSTPLHLAARDGLLDCV 227
               LH+   +D+T  A   +    +  AD+      N  T +G TPLH+AA  G ++  
Sbjct: 171 RLPALHIAARKDDTKSA--ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228

Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKK 273
            +L+  GA V      G  P+       +    + L D   + D K
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 5/152 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           +A  G V+     L           KGFT +H AA++G L   ++L++  +   D    N
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKN 595

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H DN  VAL     LLEKGA  +A   NG TPLH+AA+   +     L+  
Sbjct: 596 GLTPLHVAAHYDNQKVAL----LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
           GA  +     G  P+       H      L D
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 43/128 (33%), Positives = 67/128 (52%), Gaps = 5/128 (3%)

Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
           T + GFT +H AA +G +    +L+      VD    N  TPLH+   R NT +    + 
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNM----VK 283

Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
            LL++G  ++A+T +G TPLH AAR G    V++L++ GA + A+   G  P+      +
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343

Query: 256 HRACARFL 263
           H  C + L
Sbjct: 344 HVECVKHL 351



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G++  +   L        T+ +G TA+H AA+ G++  ++ L+      VD     
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARARE 496

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
            QTPLH+      T +    +  LL+  A  +A T NG TPLH++AR+G +D   VL+++
Sbjct: 497 EQTPLHIASRLGKTEI----VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552

Query: 234 GANVHAQDAMGYKPI 248
           GA        G+ P+
Sbjct: 553 GAAHSLATKKGFTPL 567



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 43/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ + +   L +    +     G + +H AAQ   + C++ L++ +K PVD +T +
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-HKAPVDDVTLD 364

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             T LH+  H  +  V       LL+K A+ NA+  NG TPLH+A +   +  +++LV+ 
Sbjct: 365 YLTALHVAAHCGHYRVTK----LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  PI       H
Sbjct: 421 GASIQAITESGLTPIHVAAFMGH 443



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 43/137 (31%), Positives = 71/137 (51%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++ +   L   +     +  G  A+H AA+ G +  +Q L+      VD  T
Sbjct: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSAT 94

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    +  L+++GA++NAQ+ NG TPL++AA++  +D VK L+
Sbjct: 95  KKGNTALHIASLAGQAEV----VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN       G+ P+
Sbjct: 151 ENGANQSTATEDGFTPL 167



 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+ + +   L++      +   G T++H AAQ  K+    +L + +    D  T  
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK-HGADQDAHTKL 727

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL +  H  N  +    + +LL++GA++NA+T NG TPLH AA+ G    + VL+Q 
Sbjct: 728 GYTPLIVACHYGNVKM----VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA  +A  A G   +   K
Sbjct: 784 GAKPNATTANGNTALAIAK 802



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 6/110 (5%)

Query: 156 LQVLVEEYKFPVDLLT--NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGST 213
           L  +VE  K  +D+ T   N    LHL     +  +    +  LL +G+ +++ T  G+T
Sbjct: 44  LDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL----VQELLGRGSSVDSATKKGNT 99

Query: 214 PLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
            LH+A+  G  + VKVLV+ GAN++AQ   G+ P+      NH    ++L
Sbjct: 100 ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 36/120 (30%), Positives = 63/120 (52%), Gaps = 5/120 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V  ++  L +         KG TA+H A+  G+   ++VLV+E    ++  + N
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQN 129

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + YLLE GA+ +  T +G TPL +A + G    V +L+++
Sbjct: 130 GFTPLYMAAQENHIDV----VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 11/134 (8%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGF---TAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
           AA   +VE ++  L     + P DD      TA+H AA  G     ++L+++   P +  
Sbjct: 339 AAQGDHVECVKHLLQH---KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP-NAR 394

Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
             N  TPLH+   ++   V    +  L++ GA + A T +G TP+H+AA  G L+ V +L
Sbjct: 395 ALNGFTPLHIACKKNRIKV----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 231 VQSGANVHAQDAMG 244
           +Q+GA+    +  G
Sbjct: 451 LQNGASPDVTNIRG 464



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G+T +  A  +G +  +  L+++    V+  T N  TPLH    + +T +    I  LL+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHI----INVLLQ 782

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
            GA  NA T NG+T L +A R G +  V  L
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 13/166 (7%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA   +++ +++ L     +    + GFT +  A Q G    + +L+E      D     
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKV 191

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADL------NAQTCNGSTPLHLAARDGLLDCV 227
               LH+   +D+T  A   +    +  AD+      N  T +G TPLH+AA  G ++  
Sbjct: 192 RLPALHIAARKDDTKSA--ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249

Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKK 273
            +L+  GA V      G  P+       +    + L D   + D K
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 49/152 (32%), Positives = 67/152 (44%), Gaps = 5/152 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           +A  G V+     L           KGFT +H AA++G L   ++L++  +   D    N
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR-RAAADSAGKN 595

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+  H DN  VAL     LLEKGA  +A   NG TPLH+AA+   +     L+  
Sbjct: 596 GLTPLHVAAHYDNQKVAL----LLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
           GA  +     G  P+       H      L D
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 43/128 (33%), Positives = 67/128 (52%), Gaps = 5/128 (3%)

Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
           T + GFT +H AA +G +    +L+      VD    N  TPLH+   R NT +    + 
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNM----VK 283

Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
            LL++G  ++A+T +G TPLH AAR G    V++L++ GA + A+   G  P+      +
Sbjct: 284 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD 343

Query: 256 HRACARFL 263
           H  C + L
Sbjct: 344 HVECVKHL 351



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G++  +   L        T+ +G TA+H AA+ G++  ++ L+      VD     
Sbjct: 438 AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARARE 496

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
            QTPLH+      T +    +  LL+  A  +A T NG TPLH++AR+G +D   VL+++
Sbjct: 497 EQTPLHIASRLGKTEI----VQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552

Query: 234 GANVHAQDAMGYKPI 248
           GA        G+ P+
Sbjct: 553 GAAHSLATKKGFTPL 567



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 43/143 (30%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ + +   L +    +     G + +H AAQ   + C++ L++ +K PVD +T +
Sbjct: 306 AARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ-HKAPVDDVTLD 364

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             T LH+  H  +  V       LL+K A+ NA+  NG TPLH+A +   +  +++LV+ 
Sbjct: 365 YLTALHVAAHCGHYRVTK----LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GA++ A    G  PI       H
Sbjct: 421 GASIQAITESGLTPIHVAAFMGH 443



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 43/137 (31%), Positives = 71/137 (51%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  GN++ +   L   +     +  G  A+H AA+ G +  +Q L+      VD  T
Sbjct: 36  LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS-SVDSAT 94

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    +  L+++GA++NAQ+ NG TPL++AA++  +D VK L+
Sbjct: 95  KKGNTALHIASLAGQAEV----VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLL 150

Query: 232 QSGANVHAQDAMGYKPI 248
           ++GAN       G+ P+
Sbjct: 151 ENGANQSTATEDGFTPL 167



 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 5/139 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A+  G+ + +   L++      +   G T++H AAQ  K+    +L + +    D  T  
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK-HGADQDAHTKL 727

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL +  H  N  +    + +LL++GA++NA+T NG TPLH AA+ G    + VL+Q 
Sbjct: 728 GYTPLIVACHYGNVKM----VNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 234 GANVHAQDAMGYKPIDFCK 252
           GA  +A  A G   +   K
Sbjct: 784 GAKPNATTANGNTALAIAK 802



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 6/110 (5%)

Query: 156 LQVLVEEYKFPVDLLT--NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGST 213
           L  +VE  K  +D+ T   N    LHL     +  +    +  LL +G+ +++ T  G+T
Sbjct: 44  LDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGL----VQELLGRGSSVDSATKKGNT 99

Query: 214 PLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
            LH+A+  G  + VKVLV+ GAN++AQ   G+ P+      NH    ++L
Sbjct: 100 ALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 36/120 (30%), Positives = 63/120 (52%), Gaps = 5/120 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+V  ++  L +         KG TA+H A+  G+   ++VLV+E    ++  + N
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQN 129

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPL++    ++  V    + YLLE GA+ +  T +G TPL +A + G    V +L+++
Sbjct: 130 GFTPLYMAAQENHIDV----VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 41/134 (30%), Positives = 68/134 (50%), Gaps = 11/134 (8%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGF---TAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
           AA   +VE ++  L     + P DD      TA+H AA  G     ++L+++   P +  
Sbjct: 339 AAQGDHVECVKHLLQH---KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP-NAR 394

Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
             N  TPLH+   ++   V    +  L++ GA + A T +G TP+H+AA  G L+ V +L
Sbjct: 395 ALNGFTPLHIACKKNRIKV----MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 231 VQSGANVHAQDAMG 244
           +Q+GA+    +  G
Sbjct: 451 LQNGASPDVTNIRG 464



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 5/91 (5%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G+T +  A  +G +  +  L+++    V+  T N  TPLH    + +T +    I  LL+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGA-NVNAKTKNGYTPLHQAAQQGHTHI----INVLLQ 782

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
            GA  NA T NG+T L +A R G +  V  L
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 39/166 (23%), Positives = 67/166 (40%), Gaps = 13/166 (7%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA   +++ +++ L     +    + GFT +  A Q G    + +L+E      D     
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-----DTKGKV 191

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADL------NAQTCNGSTPLHLAARDGLLDCV 227
               LH+   +D+T  A   +    +  AD+      N  T +G TPLH+AA  G ++  
Sbjct: 192 RLPALHIAARKDDTKSA--ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 249

Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKK 273
            +L+  GA V      G  P+       +    + L D   + D K
Sbjct: 250 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 65/221 (29%), Positives = 100/221 (45%), Gaps = 26/221 (11%)

Query: 34  GSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATAL------ARPRRPAS--LTP 85
           G ++ AN +  K+   DA  K    PL  +A H   Q  AL      A P   A    TP
Sbjct: 576 GKLEVANLLLQKSASPDAAGKSGLTPL-HVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634

Query: 86  PRADPSPSKE----------SDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIP 135
                  ++           +D  A+ +  I S +   AA  G+V+ +   L ++     
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH--LAAQEGHVDMVSLLLGRNANVNL 692

Query: 136 TDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
           ++  G T +H AAQ  ++   +VLV +    VD  T    TPLH+  H  N  +    + 
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAH-VDAQTKMGYTPLHVGCHYGNIKI----VN 747

Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGAN 236
           +LL+  A +NA+T NG TPLH AA+ G    + VL+Q+ A+
Sbjct: 748 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 43/142 (30%), Positives = 74/142 (52%), Gaps = 5/142 (3%)

Query: 115 AAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNS 174
           A  G+ + +   L+++   +     G + +H A Q   L C+Q+L++ +  PVD +TN+ 
Sbjct: 309 ARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDDVTNDY 367

Query: 175 QTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSG 234
            T LH+  H  +  VA      LL+K A+ NA+  NG TPLH+A +   +  +++L++ G
Sbjct: 368 LTALHVAAHCGHYKVAK----VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHG 423

Query: 235 ANVHAQDAMGYKPIDFCKIWNH 256
           A++ A    G  PI       H
Sbjct: 424 ASIQAVTESGLTPIHVAAFMGH 445



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+V  +   ++       T+ +G TA+H AA+ G+   ++ LV++    V+    +
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA-QVEAKAKD 498

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
            QTPLH+        +    +  LL++GA  NA T +G TPLHL+AR+G  D    L+  
Sbjct: 499 DQTPLHISARLGKADI----VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554

Query: 234 GANVHAQDAMGYKPI 248
           GA++      G+ P+
Sbjct: 555 GASLSITTKKGFTPL 569



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 5/124 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           GFT +H AA +G +    +L+      VD    N  TPLH+   R N  +    +  LL+
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAA-AVDFTARNDITPLHVASKRGNANM----VKLLLD 289

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
           +GA ++A+T +G TPLH  AR G    V++L+   A + ++   G  P+      +H  C
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349

Query: 260 ARFL 263
            + L
Sbjct: 350 VQLL 353



 Score = 65.5 bits (158), Expect = 7e-11
 Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 5/152 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G  E +R+ +    +         T +H +A+ GK   +Q L+++   P +  T +
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP-NAATTS 531

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLHL     +  VA     +LL+ GA L+  T  G TPLH+AA+ G L+   +L+Q 
Sbjct: 532 GYTPLHLSAREGHEDVAA----FLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
            A+  A    G  P+     ++++  A  L D
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 42/135 (31%), Positives = 63/135 (46%), Gaps = 5/135 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G +E     L +S         G T +H AA +       +L+++   P      N
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP-HAAAKN 630

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH+   ++   +A      LLE GAD NA T  G   +HLAA++G +D V +L+  
Sbjct: 631 GYTPLHIAAKKNQMDIATT----LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686

Query: 234 GANVHAQDAMGYKPI 248
            ANV+  +  G  P+
Sbjct: 687 NANVNLSNKSGLTPL 701



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 68/287 (23%), Positives = 106/287 (36%), Gaps = 79/287 (27%)

Query: 23  GRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATALARPRRPAS 82
           G  A      SG  +    +       +A++K    PL     H+SA+   L +      
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL-----HISAR---LGKADIVQQ 517

Query: 83  LTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFT 142
           L    A P+ +  S  T +            +A  G+ +   F L+       T  KGFT
Sbjct: 518 LLQQGASPNAATTSGYTPLH----------LSAREGHEDVAAFLLDHGASLSITTKKGFT 567

Query: 143 AIHFAAQWGKLACLQVLVEEYKFP---------------------VDLL----------- 170
            +H AA++GKL    +L+++   P                     V LL           
Sbjct: 568 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA 627

Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYY-----------------------------LLEKG 201
             N  TPLH+   ++   +A   + Y                             LL + 
Sbjct: 628 AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687

Query: 202 ADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
           A++N    +G TPLHLAA++  ++  +VLV  GA+V AQ  MGY P+
Sbjct: 688 ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPL 734



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 40/128 (31%), Positives = 60/128 (46%), Gaps = 5/128 (3%)

Query: 138 DKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYL 197
           + G T IH AA  G +  +  L+     P +      +T LH+        V    + YL
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASP-NTTNVRGETALHMAARSGQAEV----VRYL 485

Query: 198 LEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHR 257
           ++ GA + A+  +  TPLH++AR G  D V+ L+Q GA+ +A    GY P+       H 
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545

Query: 258 ACARFLKD 265
             A FL D
Sbjct: 546 DVAAFLLD 553



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 4/99 (4%)

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
           +++   N    LHL     +  V    +  LL++ A+++A T  G+T LH+A+  G  + 
Sbjct: 67  INICNQNGLNALHLASKEGHVEV----VSELLQREANVDAATKKGNTALHIASLAGQAEV 122

Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
           VKVLV +GANV+AQ   G+ P+      NH    +FL D
Sbjct: 123 VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 39/137 (28%), Positives = 68/137 (49%), Gaps = 5/137 (3%)

Query: 112 LFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLT 171
           L AA  G++E     +   +     +  G  A+H A++ G +  +  L++  +  VD  T
Sbjct: 46  LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR-EANVDAAT 104

Query: 172 NNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
               T LH+        V    +  L+  GA++NAQ+ NG TPL++AA++  L+ VK L+
Sbjct: 105 KKGNTALHIASLAGQAEV----VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL 160

Query: 232 QSGANVHAQDAMGYKPI 248
            +GA+       G+ P+
Sbjct: 161 DNGASQSLATEDGFTPL 177



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 38/143 (26%), Positives = 69/143 (48%), Gaps = 5/143 (3%)

Query: 95  ESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLA 154
           ++D  A  ++  G      AA  GN+      LN++     T     T +H A++ G   
Sbjct: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282

Query: 155 CLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTP 214
            +++L++     +D  T +  TPLH      +  V    +  LL++ A + ++T NG +P
Sbjct: 283 MVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQV----VEMLLDRAAPILSKTKNGLSP 337

Query: 215 LHLAARDGLLDCVKVLVQSGANV 237
           LH+A +   L+CV++L+Q    V
Sbjct: 338 LHMATQGDHLNCVQLLLQHNVPV 360



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 46/180 (25%), Positives = 73/180 (40%), Gaps = 32/180 (17%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVE------------ 161
           AA   ++E ++F L+    +    + GFT +  A Q G    + +L+E            
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL 206

Query: 162 -------EYKFPVDLLTNNSQ---------TPLHLVIHRDNTTVALPCIYYLLEKGADLN 205
                  + K    LL N++          TPLH+  H  N  VA      LL + A ++
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVAT----LLLNRAAAVD 262

Query: 206 AQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
               N  TPLH+A++ G  + VK+L+  GA + A+   G  P+       H      L D
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD 322



 Score = 33.5 bits (75), Expect = 0.28
 Identities = 17/57 (29%), Positives = 28/57 (49%)

Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNS 174
           GN++ + F L  S +       G+T +H AAQ G    + VL++    P +L  N +
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 52/146 (35%), Positives = 72/146 (49%), Gaps = 7/146 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDD-KGFTAIHFAAQWGKLACLQVLV--EEYKFPVDLL 170
           AA  G+VE +   +NQ    +  D     T IH AA  G   CL++L+   E +  VD+ 
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649

Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
             N QTPL L +   +T     C+Y LL KGA+++A+   G T LH  A  G  +CV  L
Sbjct: 650 DGNGQTPLMLSVLNGHTD----CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705

Query: 231 VQSGANVHAQDAMGYKPIDFCKIWNH 256
           +Q GA    +D+ G  PI       H
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGH 731



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 49/141 (34%), Positives = 71/141 (50%), Gaps = 7/141 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA   +VE L+  L+ + +    D  G T +  AA+ G+   +++LV      + L  N+
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGAD---LNAQTCNGSTPLHLAARDGLLDCVKVL 230
             T LHL   + + T AL     +LEK  D   +NA      TPLH+AAR+GL   V+ L
Sbjct: 890 KNTALHLACSKGHETSAL----LILEKITDRNLINATNAALQTPLHVAARNGLTMVVQEL 945

Query: 231 VQSGANVHAQDAMGYKPIDFC 251
           +  GA+V A D  GY P   C
Sbjct: 946 LGKGASVLAVDENGYTPALAC 966



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 45/145 (31%), Positives = 69/145 (47%), Gaps = 5/145 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+ E ++  L++       D K   AIH+AA  G +  +++LV  +   V      
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS-HGAEVTCKDKK 205

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
           S TPLH        +V    + YLL+ G D+N     G+TPLH+A  +G    V  L+  
Sbjct: 206 SYTPLHAAASSGMISV----VKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRA 258
           GA V+ ++  G+ P+ F     H A
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGA 286



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 38/113 (33%), Positives = 61/113 (53%), Gaps = 6/113 (5%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D+ G+TA+H+A   G   C+++L+E+  F       N+ +PLH  +  DN   A   I  
Sbjct: 753 DNHGYTALHWACYNGHETCVELLLEQEVF--QKTEGNAFSPLHCAVINDNEGAAEMLIDT 810

Query: 197 LLEKGADL-NAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
           L   GA + NA    G TPLH AA    ++C+++L+   A V++ D+ G  P+
Sbjct: 811 L---GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 45/153 (29%), Positives = 68/153 (44%), Gaps = 10/153 (6%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G  +  R  L+        DD G T +H AA  G L CL +L+       +     
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA-DFNKKDKF 437

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAAR---DGLLDCVKVL 230
            ++PLH      N      C++ L+  GA +N     G TPLH AA    DG   C++ L
Sbjct: 438 GRSPLHYAAANCN----YQCLFALVGSGASVNDLDERGCTPLHYAATSDTDG--KCLEYL 491

Query: 231 VQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           +++ AN   +D  GY  + +   + HR C + +
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 42/176 (23%), Positives = 79/176 (44%), Gaps = 35/176 (19%)

Query: 113 FAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTN 172
           +AA +G++E ++  ++        D K +T +H AA  G ++ ++ L++     VD+   
Sbjct: 179 WAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD---LGVDMNEP 235

Query: 173 NS--QTPLHL------------------VIHRDNTTVALP------------CIYYLLEK 200
           N+   TPLH+                  ++++ N     P            C+  L+  
Sbjct: 236 NAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGN 295

Query: 201 GADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           GAD+N ++ +G TPLH+ A  G     + ++QSGA +  +D  G  P+     + H
Sbjct: 296 GADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351



 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 41/139 (29%), Positives = 70/139 (50%), Gaps = 6/139 (4%)

Query: 137 DDKGFTAIHFAAQWGKLA-CLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
           ++KGFT +HFAA     A CL++LV      V++ + + +TPLH+       + +     
Sbjct: 269 NEKGFTPLHFAAASTHGALCLELLVGNGA-DVNMKSKDGKTPLHMTALHGRFSRSQT--- 324

Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
            +++ GA ++ +  NG+TPLH+AAR G    +  L+ SGA+   +   G  P+    +  
Sbjct: 325 -IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383

Query: 256 HRACARFLKDAMWKKDKKD 274
              C R L  + +  D  D
Sbjct: 384 FSDCCRKLLSSGFDIDTPD 402



 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 60/227 (26%), Positives = 97/227 (42%), Gaps = 19/227 (8%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+ E +   +    R    D K  T +H A        +QVL++ +   V+    N
Sbjct: 48  AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLK-HSADVNARDKN 106

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
            QTPLH+         A+ C   L+   +++N     G T LH AA  G  + VK+L+  
Sbjct: 107 WQTPLHIAA----ANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLKD---AMWKKDKKDFAREMTKMKMFKSQLT 290
           GAN++A D    + I +     H    + L      +  KDKK +    T +    S   
Sbjct: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSY----TPLHAAASSGM 218

Query: 291 LMEHNYLIEYQGQGCSVHFPFAF--SPITPETLLWQDISL--LSDCG 333
           +    YL++    G  ++ P A+  +P+       QD+ +  L DCG
Sbjct: 219 ISVVKYLLDL---GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCG 262



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 37/135 (27%), Positives = 58/135 (42%), Gaps = 5/135 (3%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G T +H  A  G+ +  Q +++     +D    N  TPLH+     +  +    I  L+ 
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAV-IDCEDKNGNTPLHIAARYGHELL----INTLIT 360

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
            GAD   +  +G  PLHLAA  G  DC + L+ SG ++   D  G   +       +  C
Sbjct: 361 SGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC 420

Query: 260 ARFLKDAMWKKDKKD 274
              L +     +KKD
Sbjct: 421 LNLLLNTGADFNKKD 435



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 37/111 (33%), Positives = 52/111 (46%), Gaps = 5/111 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G   +H AA  G   C + L+    F +D   +  +T LH      N    L C+  LL 
Sbjct: 372 GMFPLHLAALSGFSDCCRKLLSS-GFDIDTPDDFGRTCLHAAAAGGN----LECLNLLLN 426

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDF 250
            GAD N +   G +PLH AA +    C+  LV SGA+V+  D  G  P+ +
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHY 477



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 45/159 (28%), Positives = 70/159 (44%), Gaps = 18/159 (11%)

Query: 127 LNQSLREIPT-DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN---SQTPLHLVI 182
           L QSL ++   +  G T +  AA  G + C+ VL+ +      +L  +    +TP+H   
Sbjct: 569 LVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQ---GASILVKDYILKRTPIHAAA 625

Query: 183 HRDNTTVALPCIYYLLEKGADLNA---QTCNGSTPLHLAARDGLLDCVKVLVQSGANVHA 239
              ++     C+  L+      NA   Q  NG TPL L+  +G  DCV  L+  GANV A
Sbjct: 626 TNGHSE----CLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA 681

Query: 240 QDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFARE 278
           +D  G   +    +  H  C     DA+ +   K   R+
Sbjct: 682 KDKWGRTALHRGAVTGHEECV----DALLQHGAKCLLRD 716



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 30/129 (23%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +G+ A+H++A +G   CLQ++  E   P+D+L   S                      
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASET--PLDVLMETS---------------------- 537

Query: 197 LLEKGADLNAQTCNGST--PLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIW 254
               G D+ + + N +T  PLHLAA  G    ++VLVQS  ++  +++ G  P+D     
Sbjct: 538 ----GTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFK 593

Query: 255 NHRACARFL 263
            H  C   L
Sbjct: 594 GHVECVDVL 602



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 38/143 (26%), Positives = 65/143 (45%), Gaps = 11/143 (7%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D++  T +H AA  G    +++L+      V+   +   TPLH  +     + +   +  
Sbjct: 38  DNEKRTPLHAAAYLGDAEIIELLILSGA-RVNAKDSKWLTPLHRAV----ASCSEEAVQV 92

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL+  AD+NA+  N  TPLH+AA +  + C + LV   +NV+  D  G   +       H
Sbjct: 93  LLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGH 152

Query: 257 RACARFLK------DAMWKKDKK 273
               + L       +A  KKD++
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRR 175



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 25/71 (35%), Positives = 39/71 (54%), Gaps = 7/71 (9%)

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           L+ K  D+N Q     TPLH AA  G  + +++L+ SGA V+A+D+    P+       H
Sbjct: 27  LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPL-------H 79

Query: 257 RACARFLKDAM 267
           RA A   ++A+
Sbjct: 80  RAVASCSEEAV 90


>gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens]
          Length = 288

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 46/135 (34%), Positives = 67/135 (49%), Gaps = 6/135 (4%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           A  V + + +   L +       D    TA+H+AA+  + AC++VL+E Y    + L  N
Sbjct: 60  ACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLE-YGANPNALDGN 117

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH    ++N      C+  LLE GA +NA   N  TPL  AA  G L+ V +L+  
Sbjct: 118 RDTPLHWAAFKNNAE----CVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDY 173

Query: 234 GANVHAQDAMGYKPI 248
           GA V   + +G  PI
Sbjct: 174 GAEVRVINLIGQTPI 188



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 38/122 (31%), Positives = 60/122 (49%), Gaps = 6/122 (4%)

Query: 144 IHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGAD 203
           +H A       C+++L+E+    V+ L   ++T LH    +D       C+  LLE GA+
Sbjct: 57  LHCACMVSDADCVELLLEKGA-EVNALDGYNRTALHYAAEKDEA-----CVEVLLEYGAN 110

Query: 204 LNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
            NA   N  TPLH AA     +CV+ L++SGA+V+A D     P+ +  +  +      L
Sbjct: 111 PNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 170

Query: 264 KD 265
            D
Sbjct: 171 LD 172



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 32/96 (33%), Positives = 47/96 (48%), Gaps = 5/96 (5%)

Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
           T+ +  PLH      +      C+  LLEKGA++NA      T LH AA      CV+VL
Sbjct: 50  THGTLKPLHCACMVSDAD----CVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVL 104

Query: 231 VQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDA 266
           ++ GAN +A D     P+ +    N+  C R L ++
Sbjct: 105 LEYGANPNALDGNRDTPLHWAAFKNNAECVRALLES 140


>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
           a [Homo sapiens]
          Length = 518

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 47/135 (34%), Positives = 70/135 (51%), Gaps = 12/135 (8%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLV-----EEYKFPVD 168
           AA  GNV+ LR  L +       D++G+  IH AA    + CLQ+L+     E Y   + 
Sbjct: 17  AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY---IK 73

Query: 169 LLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVK 228
           + T      LHL   + +  +    +  LLE GAD NA T   +TPL LA  +G +D ++
Sbjct: 74  MKTFEGFCALHLAASQGHWKI----VQILLEAGADPNATTLEETTPLFLAVENGQIDVLR 129

Query: 229 VLVQSGANVHAQDAM 243
           +L+Q GANV+   +M
Sbjct: 130 LLLQHGANVNGSHSM 144



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 34/183 (18%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDK---GFTAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
           AA   +VE L+  +N    E     K   GF A+H AA  G    +Q+L+E    P +  
Sbjct: 50  AAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP-NAT 108

Query: 171 TNNSQTPLHLVI------------------------------HRDNTTVALPCIYYLLEK 200
           T    TPL L +                              H+ +       I  LL K
Sbjct: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168

Query: 201 GADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACA 260
           GA+   Q   G TPL +AA+ G L+ + +L+ SGANV+ Q      P+       H  C 
Sbjct: 169 GANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCV 228

Query: 261 RFL 263
             L
Sbjct: 229 ELL 231



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 40/155 (25%), Positives = 63/155 (40%), Gaps = 52/155 (33%)

Query: 119 NVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPL 178
           N E ++  L +   +   DD G T +  AAQ+GKL  L +L+                  
Sbjct: 158 NAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS---------------- 201

Query: 179 HLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGAN-- 236
                                 GA++N Q  + +TPL +AA++G   CV++L+ SGA+  
Sbjct: 202 ----------------------GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239

Query: 237 -----------VHAQDAMGY-KPIDFCKIWNHRAC 259
                      +HA   MG+ K +D      +RAC
Sbjct: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC 274



 Score = 33.1 bits (74), Expect = 0.37
 Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 10/81 (12%)

Query: 206 AQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
           A TC+    + LAAR+G +  ++ L++ G +V   D  G+ PI      N   C + L +
Sbjct: 8   ADTCS---TVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLIN 64

Query: 266 AMWKKDKKDFAREMTKMKMFK 286
           A       D +    KMK F+
Sbjct: 65  A-------DSSENYIKMKTFE 78


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 47/138 (34%), Positives = 65/138 (47%), Gaps = 1/138 (0%)

Query: 114  AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
            AA   NV  LR  L        TD  G TA+  AA+ G+ A ++ L+   K  + +L  N
Sbjct: 865  AAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDEN 924

Query: 174  SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
              T LHL   + +   AL  +    + G  +NA       PLH+AAR+GL   V+ L+  
Sbjct: 925  KNTALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAARNGLASVVQALLSH 983

Query: 234  GANVHAQDAMGYKPIDFC 251
            GA V A D  G+ P   C
Sbjct: 984  GATVLAVDEEGHTPALAC 1001



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 61/236 (25%), Positives = 95/236 (40%), Gaps = 26/236 (11%)

Query: 23  GRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLA--DHLSAQATALARPRRP 80
           GR A      SG ++  N +  K    +   K+  QPL   A   HL      +AR    
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG--- 196

Query: 81  ASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKG 140
                          +D    D+   G  +   AAA G +E +++ L         +  G
Sbjct: 197 ---------------ADLGCKDRKGYGLLHT--AAASGQIEVVKYLLRMGAEIDEPNAFG 239

Query: 141 FTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
            TA+H A   G+ A    LV      V+   +   TPLH+     N  +   C+  L+  
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGA-NVNQPNDKGFTPLHVAAVSTNGAL---CLELLVNN 295

Query: 201 GADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           GAD+N Q+  G +PLH+AA  G     ++L+Q+G+ +   D  G  P+     + H
Sbjct: 296 GADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGH 351



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 44/136 (32%), Positives = 60/136 (44%), Gaps = 6/136 (4%)

Query: 141 FTAIHFAAQWGKLACLQVLVE--EYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLL 198
           +T +H AA  G    L +L++  E     D++    QTPL L I   +    + C++ LL
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGH----VDCVHLLL 708

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           EKG+  +A    G T LH  A  G  DC+  L+   A V  +D  G  PI       H A
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768

Query: 259 CARFLKDAMWKKDKKD 274
             R L  A    D  D
Sbjct: 769 VLRTLLQAALSTDPLD 784



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 46/138 (33%), Positives = 70/138 (50%), Gaps = 14/138 (10%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDD----KGFTAIHFAAQWGKLACLQVLVEEYKFPVDL 169
           A+A G+   LR  L  +L   P D      G++ +H+A+  G   CL++L+E    P   
Sbjct: 761 ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS--PFSY 818

Query: 170 LTNNSQTPLHLVI--HRDNTTVALPCIYYLLEKGADL-NAQTCNGSTPLHLAARDGLLDC 226
           L  N  TPLH  +  ++D+TT  L     L   GA + N++   G TPLH AA    +  
Sbjct: 819 LEGNPFTPLHCAVINNQDSTTEML-----LGALGAKIVNSRDAKGRTPLHAAAFADNVSG 873

Query: 227 VKVLVQSGANVHAQDAMG 244
           +++L+Q  A V+A D  G
Sbjct: 874 LRMLLQHQAEVNATDHTG 891



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 30/86 (34%), Positives = 41/86 (47%), Gaps = 4/86 (4%)

Query: 165 FPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLL 224
           F ++   N  +T LH      N    + C+  LL  GADL  +   G TPLH AA +G  
Sbjct: 414 FDINTPDNLGRTCLHAAASGGN----VECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469

Query: 225 DCVKVLVQSGANVHAQDAMGYKPIDF 250
            C   LV +GA V+  D  G  P+ +
Sbjct: 470 QCAVTLVTAGAGVNEADCKGCSPLHY 495



 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 8/129 (6%)

Query: 137 DDKGFTAIHFAA-QWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLV-IHRDNTTVALPCI 194
           +DKGFT +H AA       CL++LV      V+  +   ++PLH+  IH   T   +   
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGA-DVNYQSKEGKSPLHMAAIHGRFTRSQI--- 324

Query: 195 YYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIW 254
             L++ G++++     G+TPLH+AAR G    +  L+ +GA+   +      P+    ++
Sbjct: 325 --LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLF 382

Query: 255 NHRACARFL 263
               C R L
Sbjct: 383 GFSDCCRKL 391



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 5/115 (4%)

Query: 123 LRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVE-EYKFPVDLLTNNSQTPLHLV 181
           L F L+        D +G+TA+H+AA +G    L++L+E  +    D+ +    +PLHL 
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592

Query: 182 IHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGAN 236
            +  +       +  L E   +L+ +   G T L LA   G  +CV+VL   GA+
Sbjct: 593 AYNGH----CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGAS 643



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 42/157 (26%), Positives = 66/157 (42%), Gaps = 12/157 (7%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDK---GFTAIHFAAQWGKLACLQVLVEEYKFPVDLL 170
           AAA G+ + L   ++   R   TD     G T +  A   G + C+ +L+E+     D  
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS-TADAA 717

Query: 171 TNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVL 230
               +T LH    R   T    C+  LL+  A +  +   G TP+HLA+  G    ++ L
Sbjct: 718 DLRGRTALH----RGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773

Query: 231 VQSGANVHAQDA----MGYKPIDFCKIWNHRACARFL 263
           +Q+  +    DA     GY P+ +     H  C   L
Sbjct: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 43/158 (27%), Positives = 69/158 (43%), Gaps = 34/158 (21%)

Query: 127 LNQSLREIPTDDK-GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQT--------- 176
           L Q+  EI   DK G T +H AA++G     ++L+        L+TN + T         
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGH----ELLIST------LMTNGADTARRGIHDMF 374

Query: 177 PLHLVI--------------HRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDG 222
           PLHL +               +  + V+     ++L  G D+N     G T LH AA  G
Sbjct: 375 PLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGG 434

Query: 223 LLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACA 260
            ++C+ +L+ SGA++  +D  G  P+ +        CA
Sbjct: 435 NVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCA 472



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 39/150 (26%), Positives = 60/150 (40%), Gaps = 5/150 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA VG+V  L+  L         D    T +H AA       L +L+  +   V+     
Sbjct: 48  AAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLA-HSADVNARDKL 106

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
            QTPLH+         A  C   L    + LN    +G + LH A   G L+ V +L+  
Sbjct: 107 WQTPLHVAA----ANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           GA+++  D    +P+ +     H    + L
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLL 192



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 4/97 (4%)

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDC 226
           +++L    +TPLH   +  +    +P +  LL  GA++NA+     TPLH AA       
Sbjct: 34  INVLDQERRTPLHAAAYVGD----VPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKV 89

Query: 227 VKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           + +L+   A+V+A+D +   P+          CA  L
Sbjct: 90  LGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 44/187 (23%), Positives = 68/187 (36%), Gaps = 27/187 (14%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA+ GNVE L   L+        D  G T +H+AA  G   C   LV      V+     
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTA-GAGVNEADCK 488

Query: 174 SQTPLHLVIHRDNTTVALP------------------------CIYYLLEKGADLNAQTC 209
             +PLH     D    A P                        C+ +LL+ GAD + +  
Sbjct: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548

Query: 210 NGSTPLHLAARDGLLDCVKVLVQSGANV--HAQDAMGYKPIDFCKIWNHRACARFLKDAM 267
            G T +H AA  G    +++L++   N     +  +   P+       H    + L + +
Sbjct: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608

Query: 268 WKKDKKD 274
              D +D
Sbjct: 609 VNLDVRD 615



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 33/128 (25%), Positives = 55/128 (42%), Gaps = 1/128 (0%)

Query: 105 AIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYK 164
           A G    + A   G+V+ +   L +       D +G TA+H  A  G   CL  L++   
Sbjct: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745

Query: 165 FPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLL 224
           F V       +TP+HL     +T V    +   L           +G +P+H A+  G  
Sbjct: 746 F-VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804

Query: 225 DCVKVLVQ 232
           DC+++L++
Sbjct: 805 DCLELLLE 812



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 7/64 (10%)

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           LL +  ++N       TPLH AA  G +  +++L+ SGANV+A+D +   P+       H
Sbjct: 27  LLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPL-------H 79

Query: 257 RACA 260
           RA A
Sbjct: 80  RAAA 83


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 56/176 (31%), Positives = 85/176 (48%), Gaps = 9/176 (5%)

Query: 100 AIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLR-EIPTDDKGFTAIHFAAQWGKLACLQV 158
           A+DQ+  G  +   AAA G     +  L      E+PT  +G+T +H AA  G L  + +
Sbjct: 555 ALDQSGYGPLHT--AAARGKYLICKMLLRYGASLELPTH-QGWTPLHLAAYKGHLEIIHL 611

Query: 159 LVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLA 218
           L E +   +  L   + TPLHL        V    +  LL+ GAD NA   +G TPLHLA
Sbjct: 612 LAESHA-NMGALGAVNWTPLHLAARHGEEAV----VSALLQCGADPNAAEQSGWTPLHLA 666

Query: 219 ARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKD 274
            +      V  L++  ANVHA++ +G+ P     +  + A  + L +A  + D +D
Sbjct: 667 VQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 47/149 (31%), Positives = 72/149 (48%), Gaps = 12/149 (8%)

Query: 113 FAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTN 172
           FAA  G+    R  L+        + +G+T +H AAQ       ++LV     P +L   
Sbjct: 434 FAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADP-NLHEA 492

Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQ 232
             +TPLH+  +  + ++    +  L  +GA+L+AQ  N  TPLHLA   G +  ++ L++
Sbjct: 493 EGKTPLHVAAYFGHVSL----VKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548

Query: 233 SGANVHAQDAMGYKPIDFCKIWNHRACAR 261
           SGA   A D  GY P+       H A AR
Sbjct: 549 SGAVPDALDQSGYGPL-------HTAAAR 570



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 36/108 (33%), Positives = 57/108 (52%), Gaps = 5/108 (4%)

Query: 141 FTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
           +T +H AA+ G+ A +  L++    P +    +  TPLHL + R         +  LLE 
Sbjct: 627 WTPLHLAARHGEEAVVSALLQCGADP-NAAEQSGWTPLHLAVQRSTFL----SVINLLEH 681

Query: 201 GADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPI 248
            A+++A+   G TP HLAA  G    +KVLV++GA +  QD +   P+
Sbjct: 682 HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 5/128 (3%)

Query: 139 KGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLL 198
           +G T +H AA +G ++ +++L  +    +D    N +TPLHL + R         I +LL
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGA-ELDAQQRNLRTPLHLAVERGKVRA----IQHLL 547

Query: 199 EKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRA 258
           + GA  +A   +G  PLH AA  G     K+L++ GA++      G+ P+       H  
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607

Query: 259 CARFLKDA 266
               L ++
Sbjct: 608 IIHLLAES 615



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 7/152 (4%)

Query: 113 FAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTN 172
           F  A G+VE +R  L   +        G+T +  AAQ  +   L  L+  +    + +  
Sbjct: 368 FLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQ-DQQPDLCALLLAHGADANRVDE 426

Query: 173 NSQTPLHLVIHR-DNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLV 231
           +   PLH      D+ T  L     LL+ GA ++AQ   G TPLHLAA++   +  ++LV
Sbjct: 427 DGWAPLHFAAQNGDDGTARL-----LLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481

Query: 232 QSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
              A+ +  +A G  P+     + H +  + L
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQ 232
           N  TPLH ++ + +       +  LL    D++ QT +G TPL +AA+D   D   +L+ 
Sbjct: 361 NKVTPLHFLVAQGSVEQ----VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416

Query: 233 SGANVHAQDAMGYKPIDFCKIWNHRACARFLKD 265
            GA+ +  D  G+ P+ F         AR L D
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLD 449


>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
           sapiens]
          Length = 313

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 47/162 (29%), Positives = 81/162 (50%), Gaps = 7/162 (4%)

Query: 108 SYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPV 167
           S +QL  AA G + +L   + Q      TD++GFT + +AA  G++A ++ L++    P 
Sbjct: 152 SVHQL--AAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADP- 208

Query: 168 DLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCV 227
            LL    ++ L L   +  T +    +  LL+ G D+N    NG TPL  A     + CV
Sbjct: 209 QLLGKGRESALSLACSKGYTDI----VKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCV 264

Query: 228 KVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWK 269
           K+L++SGA+   +   GY  +D      +R+  + ++  + K
Sbjct: 265 KMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLK 306


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 4/94 (4%)

Query: 170 LTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKV 229
           LT N  T LHL +++DN  +    I  LL  GAD+      G T LH+A   G L+   V
Sbjct: 97  LTRNGFTALHLAVYKDNAEL----ITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADV 152

Query: 230 LVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           L+Q GANV+ QDA+ + P+     + H    R L
Sbjct: 153 LLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 7/126 (5%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G TA+H A   G L    VL++ +   V++      TPLH+  +  +  V       LL+
Sbjct: 134 GLTALHIATIAGHLEAADVLLQ-HGANVNIQDAVFFTPLHIAAYYGHEQVTR----LLLK 188

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSG--ANVHAQDAMGYKPIDFCKIWNHR 257
            GAD+N     G  PLHLA+  G L+  K+L++ G  A+V+AQD   + P+ FC  + H 
Sbjct: 189 FGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHH 248

Query: 258 ACARFL 263
              ++L
Sbjct: 249 DIVKYL 254



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 21/166 (12%)

Query: 101 IDQTAIGSYYQLFAAAV-GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVL 159
           I Q   G    L  A + G++E     L         D   FT +H AA +G     ++L
Sbjct: 127 IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186

Query: 160 VEEYKFPVDLLTNNS--QTPLHLVIHRDNTTVALPCIYYLLEKG--ADLNAQTCNGSTPL 215
           +   KF  D+  +      PLHL   +    +A      L+E+G  AD+NAQ      PL
Sbjct: 187 L---KFGADVNVSGEVGDRPLHLASAKGFLNIAK----LLMEEGSKADVNAQDNEDHVPL 239

Query: 216 HLAARDGLLDCVKVLVQSGANV--HAQDAMGYKPIDFCKIWNHRAC 259
           H  +R G  D VK L+QS   V  H  +  G  P+       H AC
Sbjct: 240 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL-------HLAC 278



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 40/156 (25%), Positives = 65/156 (41%), Gaps = 9/156 (5%)

Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
           G    +R  + + LR       GFTA+H A        +  L+      +  +     T 
Sbjct: 79  GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA-DIQQVGYGGLTA 137

Query: 178 LHLVIHRDNTTVA--LPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGA 235
           LH+       T+A  L     LL+ GA++N Q     TPLH+AA  G     ++L++ GA
Sbjct: 138 LHIA------TIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 191

Query: 236 NVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKD 271
           +V+    +G +P+           A+ L +   K D
Sbjct: 192 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 227



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 7/122 (5%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEE-YKFPVDLLTN 172
           AA  G+ +  R  L        + + G   +H A+  G L   ++L+EE  K  V+   N
Sbjct: 174 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 233

Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCN--GSTPLHLAARDGLLDCVKVL 230
               PLH      +  +    + YLL+   ++     N  G TPLHLA  +G  +  K +
Sbjct: 234 EDHVPLHFCSRFGHHDI----VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 289

Query: 231 VQ 232
           +Q
Sbjct: 290 IQ 291



 Score = 30.0 bits (66), Expect = 3.1
 Identities = 18/72 (25%), Positives = 36/72 (50%), Gaps = 5/72 (6%)

Query: 142 TAIHFAAQWGK-LACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
           TA H A  +GK +  ++ L+++    ++    +  T LH   +  +  +    + +LL+ 
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL----VQFLLDN 362

Query: 201 GADLNAQTCNGS 212
           GAD+N   C+ S
Sbjct: 363 GADMNLVACDPS 374


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 4/94 (4%)

Query: 170 LTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKV 229
           LT N  T LHL +++DN  +    I  LL  GAD+      G T LH+A   G L+   V
Sbjct: 198 LTRNGFTALHLAVYKDNAEL----ITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADV 253

Query: 230 LVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           L+Q GANV+ QDA+ + P+     + H    R L
Sbjct: 254 LLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 7/126 (5%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G TA+H A   G L    VL++ +   V++      TPLH+  +  +  V       LL+
Sbjct: 235 GLTALHIATIAGHLEAADVLLQ-HGANVNIQDAVFFTPLHIAAYYGHEQVTR----LLLK 289

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSG--ANVHAQDAMGYKPIDFCKIWNHR 257
            GAD+N     G  PLHLA+  G L+  K+L++ G  A+V+AQD   + P+ FC  + H 
Sbjct: 290 FGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHH 349

Query: 258 ACARFL 263
              ++L
Sbjct: 350 DIVKYL 355



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 21/166 (12%)

Query: 101 IDQTAIGSYYQLFAAAV-GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVL 159
           I Q   G    L  A + G++E     L         D   FT +H AA +G     ++L
Sbjct: 228 IQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287

Query: 160 VEEYKFPVDLLTNNS--QTPLHLVIHRDNTTVALPCIYYLLEKG--ADLNAQTCNGSTPL 215
           +   KF  D+  +      PLHL   +    +A      L+E+G  AD+NAQ      PL
Sbjct: 288 L---KFGADVNVSGEVGDRPLHLASAKGFLNIAK----LLMEEGSKADVNAQDNEDHVPL 340

Query: 216 HLAARDGLLDCVKVLVQSGANV--HAQDAMGYKPIDFCKIWNHRAC 259
           H  +R G  D VK L+QS   V  H  +  G  P+       H AC
Sbjct: 341 HFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPL-------HLAC 379



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 40/156 (25%), Positives = 65/156 (41%), Gaps = 9/156 (5%)

Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
           G    +R  + + LR       GFTA+H A        +  L+      +  +     T 
Sbjct: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGA-DIQQVGYGGLTA 238

Query: 178 LHLVIHRDNTTVA--LPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGA 235
           LH+       T+A  L     LL+ GA++N Q     TPLH+AA  G     ++L++ GA
Sbjct: 239 LHIA------TIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGA 292

Query: 236 NVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKD 271
           +V+    +G +P+           A+ L +   K D
Sbjct: 293 DVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 328



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 33/122 (27%), Positives = 53/122 (43%), Gaps = 7/122 (5%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEE-YKFPVDLLTN 172
           AA  G+ +  R  L        + + G   +H A+  G L   ++L+EE  K  V+   N
Sbjct: 275 AAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDN 334

Query: 173 NSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCN--GSTPLHLAARDGLLDCVKVL 230
               PLH      +  +    + YLL+   ++     N  G TPLHLA  +G  +  K +
Sbjct: 335 EDHVPLHFCSRFGHHDI----VKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEI 390

Query: 231 VQ 232
           +Q
Sbjct: 391 IQ 392



 Score = 30.0 bits (66), Expect = 3.1
 Identities = 18/72 (25%), Positives = 36/72 (50%), Gaps = 5/72 (6%)

Query: 142 TAIHFAAQWGK-LACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK 200
           TA H A  +GK +  ++ L+++    ++    +  T LH   +  +  +    + +LL+ 
Sbjct: 408 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRL----VQFLLDN 463

Query: 201 GADLNAQTCNGS 212
           GAD+N   C+ S
Sbjct: 464 GADMNLVACDPS 475


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 43/151 (28%), Positives = 70/151 (46%), Gaps = 4/151 (2%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA+ G +  ++  LN  +     +  G TA+H A   G+ A +  L++ Y   V+   NN
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID-YGANVNQPNNN 246

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH       +T    C+  L+  GAD+N Q+ +G +PLH+ A  G     + L+Q+
Sbjct: 247 GFTPLHFAAA---STHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRACARFLK 264
           G  +   D  G  P+     + H      L+
Sbjct: 304 GGEIDCVDKDGNTPLHVAARYGHELLINTLR 334



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 41/143 (28%), Positives = 69/143 (48%), Gaps = 6/143 (4%)

Query: 123 LRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN-SQTPLHLV 181
           L F L         D +G+ +IH+AA +G   CL++L+E      +   +  +++PLHL 
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549

Query: 182 IHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQD 241
            +  +       +  LL+   DL+ +   G T L LAA  G  +CV+ L+  GA++  +D
Sbjct: 550 AYNGHH----QALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605

Query: 242 AMGYK-PIDFCKIWNHRACARFL 263
            +  + P+    I  H  C R L
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLL 628



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 45/138 (32%), Positives = 68/138 (49%), Gaps = 13/138 (9%)

Query: 113 FAAAVGNVEWLRFCLNQSLREIPT---DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDL 169
           +AAA G+  WL   L  +L E      D++G+T +H+A   G   C++VL+E+  F    
Sbjct: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCF--RK 774

Query: 170 LTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTC---NGSTPLHLAARDGLLDC 226
              N  TPLH  I  D+   A      LL    D +  +C    G TPL  AA    ++C
Sbjct: 775 FIGNPFTPLHCAIINDHGNCA-----SLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVEC 829

Query: 227 VKVLVQSGANVHAQDAMG 244
           +++L++  A V+A D  G
Sbjct: 830 LQLLLRHSAPVNAVDNSG 847



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 5/145 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA  G+VE +   L +       D K   A+H+AA  G L  + +L+  +   V      
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN-HGAEVTCKDKK 180

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
             TPLH         V    + +LL  G +++     G+T LH+A  +G    V  L+  
Sbjct: 181 GYTPLHAAASNGQINV----VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236

Query: 234 GANVHAQDAMGYKPIDFCKIWNHRA 258
           GANV+  +  G+ P+ F     H A
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGA 261



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 44/143 (30%), Positives = 68/143 (47%), Gaps = 12/143 (8%)

Query: 127 LNQSLREIPT-DDKGFTAIHFAAQWGKLACLQVLVEEYK--FPVDLLTNNSQTPLHLVIH 183
           L QSL ++   D+KG TA+  AA  G   C++ L+      F  D +T   +TPLH  + 
Sbjct: 561 LLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK--RTPLHASVI 618

Query: 184 RDNTTVALPCIYYLLEKGAD---LNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ 240
             +T     C+  LLE   +   ++ +   G TPL LA   G +D V +L++  ANV   
Sbjct: 619 NGHTL----CLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTV 674

Query: 241 DAMGYKPIDFCKIWNHRACARFL 263
           D +G   +    +  H  C + L
Sbjct: 675 DILGCTALHRGIMTGHEECVQML 697



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 45/149 (30%), Positives = 67/149 (44%), Gaps = 18/149 (12%)

Query: 124 RFCLNQSL----REIPTDDK-GFTAIHFAAQWGKLACLQVL----VEEYKFPVDLLTNNS 174
           RF  +Q+L     EI   DK G T +H AA++G    +  L     +  K  +     +S
Sbjct: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGI-----HS 347

Query: 175 QTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSG 234
             PLHL     ++     C   LL  G +++     G T LH AA  G ++C+K+L  SG
Sbjct: 348 MFPLHLAALNAHSD----CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG 403

Query: 235 ANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           A+ H +D  G  P+ +     H  C   L
Sbjct: 404 ADFHKKDKCGRTPLHYAAANCHFHCIETL 432



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 37/143 (25%), Positives = 64/143 (44%), Gaps = 5/143 (3%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA +G+ E +   +    R    D+   T +H A        +QVL++ +   V+    N
Sbjct: 23  AAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK-HSADVNARDKN 81

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQS 233
            QTPLH+         A+ C   ++   + +N     G T LH AA +G ++ V +L+  
Sbjct: 82  WQTPLHVAA----ANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 234 GANVHAQDAMGYKPIDFCKIWNH 256
           GAN++A D    + + +     H
Sbjct: 138 GANINAFDKKDRRALHWAAYMGH 160



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 39/139 (28%), Positives = 67/139 (48%), Gaps = 6/139 (4%)

Query: 137 DDKGFTAIHFAAQWGKLA-CLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIY 195
           ++ GFT +HFAA     A CL++LV      V++ + + ++PLH+       T +     
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGA-DVNIQSKDGKSPLHMTAVHGRFTRSQT--- 299

Query: 196 YLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWN 255
            L++ G +++    +G+TPLH+AAR G    +  L  SGA+          P+    +  
Sbjct: 300 -LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358

Query: 256 HRACARFLKDAMWKKDKKD 274
           H  C R L  + ++ D  D
Sbjct: 359 HSDCCRKLLSSGFEIDTPD 377



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 38/136 (27%), Positives = 59/136 (43%), Gaps = 5/136 (3%)

Query: 144 IHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGAD 203
           +H AA      C + L+    F +D      +T LH      N    + CI  L   GAD
Sbjct: 351 LHLAALNAHSDCCRKLLSS-GFEIDTPDKFGRTCLHAAAAGGN----VECIKLLQSSGAD 405

Query: 204 LNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
            + +   G TPLH AA +    C++ LV +GANV+  D  G   + +    +       L
Sbjct: 406 FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTIL 465

Query: 264 KDAMWKKDKKDFAREM 279
            +A    ++ + ARE+
Sbjct: 466 GNAHDNSEELERAREL 481



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 42/165 (25%), Positives = 72/165 (43%), Gaps = 17/165 (10%)

Query: 95  ESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDD-KGFTAIHFAAQWGKL 153
           E  +TA+D           AA  G+ E +   +N        D+    T +H +   G  
Sbjct: 573 EKGRTALD----------LAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHT 622

Query: 154 ACLQVLVEEYKFP--VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNG 211
            CL++L+E    P  VD+     QTPL L +   +    +  +  LLEK A+++     G
Sbjct: 623 LCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH----IDAVSLLLEKEANVDTVDILG 678

Query: 212 STPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
            T LH     G  +CV++L++   ++  +D+ G  P+ +     H
Sbjct: 679 CTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 11/143 (7%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D +  T +H AA  G    +++L+      V+   N   TPLH  +     + +   +  
Sbjct: 13  DSEKRTPLHVAAFLGDAEIIELLILSGA-RVNAKDNMWLTPLHRAV----ASRSEEAVQV 67

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           L++  AD+NA+  N  TPLH+AA +  + C +V++   ++V+  D  G   +    +  H
Sbjct: 68  LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127

Query: 257 RACARFLK------DAMWKKDKK 273
                 L       +A  KKD++
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRR 150



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 35/136 (25%), Positives = 56/136 (41%), Gaps = 8/136 (5%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G + +H  A  G+    Q L++     +D +  +  TPLH+     +  +    I  L  
Sbjct: 281 GKSPLHMTAVHGRFTRSQTLIQNGG-EIDCVDKDGNTPLHVAARYGHELL----INTLRT 335

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
            GAD      +   PLHLAA +   DC + L+ SG  +   D  G   +       +  C
Sbjct: 336 SGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVEC 395

Query: 260 ARFLKDA---MWKKDK 272
            + L+ +     KKDK
Sbjct: 396 IKLLQSSGADFHKKDK 411



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 25/71 (35%), Positives = 39/71 (54%), Gaps = 7/71 (9%)

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           L+ K  D+N       TPLH+AA  G  + +++L+ SGA V+A+D M   P+       H
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPL-------H 54

Query: 257 RACARFLKDAM 267
           RA A   ++A+
Sbjct: 55  RAVASRSEEAV 65



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 38/154 (24%), Positives = 62/154 (40%), Gaps = 18/154 (11%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AAA GNVE ++   +        D  G T +H+AA      C++ LV      V+   + 
Sbjct: 387 AAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTT-GANVNETDDW 445

Query: 174 SQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPL----HLAARDGLLDCVKV 229
            +T LH     D            +++   +     + S  L     L  ++  L C++ 
Sbjct: 446 GRTALHYAAASD------------MDRNKTILGNAHDNSEELERARELKEKEATL-CLEF 492

Query: 230 LVQSGANVHAQDAMGYKPIDFCKIWNHRACARFL 263
           L+Q+ AN   +D  GY  I +   + HR C   L
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 8/130 (6%)

Query: 137 DDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYY 196
           D KG T +  A  +G +  + +L+E+ +  VD +     T LH    R   T    C+  
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEK-EANVDTVDILGCTALH----RGIMTGHEECVQM 696

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQ---SGANVHAQDAMGYKPIDFCKI 253
           LLE+   +  +   G TPLH AA  G    +  L+Q   S  +   +D  GY P+ +   
Sbjct: 697 LLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACY 756

Query: 254 WNHRACARFL 263
             +  C   L
Sbjct: 757 NGNENCIEVL 766



 Score = 37.4 bits (85), Expect = 0.020
 Identities = 23/78 (29%), Positives = 37/78 (47%)

Query: 114 AAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNN 173
           AA   +VE L+  L  S      D+ G TA+  AA+ G+   + +LV   +  + +   +
Sbjct: 821 AAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKD 880

Query: 174 SQTPLHLVIHRDNTTVAL 191
             TPLHL   + +   AL
Sbjct: 881 LNTPLHLACSKGHEKCAL 898


>gi|110431370 espin [Homo sapiens]
          Length = 854

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 40/125 (32%), Positives = 60/125 (48%), Gaps = 5/125 (4%)

Query: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
           G T +H AAQ G    +  LV      +     +  T +H    R +T V    + +LL 
Sbjct: 206 GMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKV----LSWLLL 261

Query: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
            G +++A    G TPLH AA +G L+C ++LV +GA +  +D  GY   D      H  C
Sbjct: 262 HGGEISADLWGG-TPLHDAAENGELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHC 320

Query: 260 ARFLK 264
            R+L+
Sbjct: 321 TRYLR 325



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 50/158 (31%), Positives = 73/158 (46%), Gaps = 7/158 (4%)

Query: 102 DQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPT--DDKGFTAIHFAAQWGKLACLQVL 159
           D+   G+     AA  G+ E + + L+    + PT   D G   IH+AA  G    L++L
Sbjct: 99  DKDNSGATVLHLAARFGHPEVVNWLLHHGGGD-PTAATDMGALPIHYAAAKGDFPSLRLL 157

Query: 160 VEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAA 219
           VE Y   V+  T N  TPL+L     +  V     Y + E GAD +A+  +G TPLH AA
Sbjct: 158 VEHYPEGVNAQTKNGATPLYLACQEGHLEVTQ---YLVQECGADPHARAHDGMTPLHAAA 214

Query: 220 RDGLLDCVKVLVQ-SGANVHAQDAMGYKPIDFCKIWNH 256
           + G    +  LV  +  ++  QD  G   + F     H
Sbjct: 215 QMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGH 252



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 52/146 (35%), Positives = 70/146 (47%), Gaps = 15/146 (10%)

Query: 112 LFAAAVGNVEWLRFC-----LNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFP 166
           L AA  G ++ LR       L  SLR+ P D      +H AA+ GKL CL+ LVEE   P
Sbjct: 7   LQAARQGELDVLRSLHAAGLLGPSLRD-PLDA---LPVHHAARAGKLHCLRFLVEEAALP 62

Query: 167 VDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEK-GADLNAQTCNGSTPLHLAARDGLLD 225
                 N  TP     H  + T  L C+ +LL + G  +  +  +G+T LHLAAR G  +
Sbjct: 63  AAARARNGATP----AHDASATGHLACLQWLLSQGGCRVQDKDNSGATVLHLAARFGHPE 118

Query: 226 CVK-VLVQSGANVHAQDAMGYKPIDF 250
            V  +L   G +  A   MG  PI +
Sbjct: 119 VVNWLLHHGGGDPTAATDMGALPIHY 144



 Score = 32.7 bits (73), Expect = 0.48
 Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 1/65 (1%)

Query: 96  SDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLAC 155
           +D +  +Q   G+    FAA+ G+ + L + L     EI  D  G T +H AA+ G+L C
Sbjct: 229 TDVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHG-GEISADLWGGTPLHDAAENGELEC 287

Query: 156 LQVLV 160
            Q+LV
Sbjct: 288 CQILV 292


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
           repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 54/204 (26%), Positives = 86/204 (42%), Gaps = 39/204 (19%)

Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
           GN+E L   L   +    +D  G  A+H AA++G   CLQ L++ Y  P +      +T 
Sbjct: 66  GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-YNCPTEHADLQGRTA 124

Query: 178 LHLVIHRD----------------------------NTTVALPCIYYLL-EKGADLNAQT 208
           LH     D                             T ++ P I  LL ++GAD+N++ 
Sbjct: 125 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRD 184

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDA-- 266
               T L L    G  D V+VL+++GA++   DA+G+    + +I ++      LK A  
Sbjct: 185 KQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASE 244

Query: 267 -------MWKKDKKDFAREMTKMK 283
                  +WKK      R +T M+
Sbjct: 245 NTNKGRELWKKGPSLQQRNLTHMQ 268



 Score = 32.7 bits (73), Expect = 0.48
 Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 4/66 (6%)

Query: 179 HLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVH 238
           H+V  + N    L C+  +L  G D+      G   LHLAA+ G   C++ L+Q      
Sbjct: 60  HVVTSKGN----LECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTE 115

Query: 239 AQDAMG 244
             D  G
Sbjct: 116 HADLQG 121



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 14/67 (20%), Positives = 27/67 (40%)

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           L +KG +       G +  H+    G L+C+  ++  G ++   D  G   +     + H
Sbjct: 41  LAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGH 100

Query: 257 RACARFL 263
             C + L
Sbjct: 101 ALCLQKL 107


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
           repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 54/204 (26%), Positives = 86/204 (42%), Gaps = 39/204 (19%)

Query: 118 GNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTP 177
           GN+E L   L   +    +D  G  A+H AA++G   CLQ L++ Y  P +      +T 
Sbjct: 79  GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-YNCPTEHADLQGRTA 137

Query: 178 LHLVIHRD----------------------------NTTVALPCIYYLL-EKGADLNAQT 208
           LH     D                             T ++ P I  LL ++GAD+N++ 
Sbjct: 138 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRD 197

Query: 209 CNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDA-- 266
               T L L    G  D V+VL+++GA++   DA+G+    + +I ++      LK A  
Sbjct: 198 KQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASE 257

Query: 267 -------MWKKDKKDFAREMTKMK 283
                  +WKK      R +T M+
Sbjct: 258 NTNKGRELWKKGPSLQQRNLTHMQ 281



 Score = 32.7 bits (73), Expect = 0.48
 Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 4/66 (6%)

Query: 179 HLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVH 238
           H+V  + N    L C+  +L  G D+      G   LHLAA+ G   C++ L+Q      
Sbjct: 73  HVVTSKGN----LECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTE 128

Query: 239 AQDAMG 244
             D  G
Sbjct: 129 HADLQG 134



 Score = 30.8 bits (68), Expect = 1.8
 Identities = 14/67 (20%), Positives = 27/67 (40%)

Query: 197 LLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNH 256
           L +KG +       G +  H+    G L+C+  ++  G ++   D  G   +     + H
Sbjct: 54  LAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGH 113

Query: 257 RACARFL 263
             C + L
Sbjct: 114 ALCLQKL 120


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.132    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,308,091
Number of Sequences: 37866
Number of extensions: 679528
Number of successful extensions: 5706
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 332
Number of HSP's successfully gapped in prelim test: 128
Number of HSP's that attempted gapping in prelim test: 3261
Number of HSP's gapped (non-prelim): 1745
length of query: 343
length of database: 18,247,518
effective HSP length: 103
effective length of query: 240
effective length of database: 14,347,320
effective search space: 3443356800
effective search space used: 3443356800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press