Search of human proteins with 112420968

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
         (1113 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112420968 coiled-coil domain containing 158 [Homo sapiens]        2118   0.0  
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   151   3e-36
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   143   8e-34
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   141   3e-33
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            140   5e-33
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   140   9e-33
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   140   9e-33
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   140   9e-33
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   140   9e-33
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    138   3e-32
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   136   1e-31
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   136   1e-31
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   136   1e-31
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   136   1e-31
gi|21735548 centrosomal protein 2 [Homo sapiens]                      135   2e-31
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   134   5e-31
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      134   5e-31
gi|34577114 cytomatrix protein p110 [Homo sapiens]                    134   6e-31
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...   133   1e-30
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   131   3e-30
gi|71061468 centromere protein E [Homo sapiens]                       131   3e-30
gi|4506751 restin isoform a [Homo sapiens]                            130   5e-30
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          130   7e-30
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          130   7e-30
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]          130   7e-30
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    130   9e-30
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   129   1e-29
gi|38044112 restin isoform b [Homo sapiens]                           129   2e-29
gi|16262452 cingulin [Homo sapiens]                                   127   4e-29
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   127   6e-29

>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
          Length = 1113

 Score = 2118 bits (5487), Expect = 0.0
 Identities = 1113/1113 (100%), Positives = 1113/1113 (100%)

Query: 1    MESKAWESNNEDLLSSSGVTSNGGSSSSFFVSSIRGTIIENTSSAGTLTQVPFFPKYEVE 60
            MESKAWESNNEDLLSSSGVTSNGGSSSSFFVSSIRGTIIENTSSAGTLTQVPFFPKYEVE
Sbjct: 1    MESKAWESNNEDLLSSSGVTSNGGSSSSFFVSSIRGTIIENTSSAGTLTQVPFFPKYEVE 60

Query: 61   LDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQ 120
            LDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQ
Sbjct: 61   LDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQ 120

Query: 121  EMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMML 180
            EMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMML
Sbjct: 121  EMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMML 180

Query: 181  SHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRI 240
            SHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRI
Sbjct: 181  SHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRI 240

Query: 241  FPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQ 300
            FPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQ
Sbjct: 241  FPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQ 300

Query: 301  MEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTE 360
            MEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTE
Sbjct: 301  MEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTE 360

Query: 361  ARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE 420
            ARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE
Sbjct: 361  ARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE 420

Query: 421  LDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKV 480
            LDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKV
Sbjct: 421  LDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKV 480

Query: 481  VEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG 540
            VEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG
Sbjct: 481  VEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG 540

Query: 541  DHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN 600
            DHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN
Sbjct: 541  DHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN 600

Query: 601  DRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLN 660
            DRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLN
Sbjct: 601  DRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLN 660

Query: 661  EVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEG 720
            EVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEG
Sbjct: 661  EVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEG 720

Query: 721  SDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELST 780
            SDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELST
Sbjct: 721  SDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELST 780

Query: 781  VATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ 840
            VATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ
Sbjct: 781  VATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ 840

Query: 841  HTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDP 900
            HTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDP
Sbjct: 841  HTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDP 900

Query: 901  TRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNN 960
            TRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNN
Sbjct: 901  TRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNN 960

Query: 961  SLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSP 1020
            SLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSP
Sbjct: 961  SLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSP 1020

Query: 1021 VHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLV 1080
            VHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLV
Sbjct: 1021 VHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLV 1080

Query: 1081 EDLQLKNQAMSSMIRNQEKRIQKVKDQEKMLLK 1113
            EDLQLKNQAMSSMIRNQEKRIQKVKDQEKMLLK
Sbjct: 1081 EDLQLKNQAMSSMIRNQEKRIQKVKDQEKMLLK 1113


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  151 bits (382), Expect = 3e-36
 Identities = 197/876 (22%), Positives = 385/876 (43%), Gaps = 116/876 (13%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNE---SNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM 129
            K +  +V+ E   Q+ +LQ        S    EKQK  L + +  L+T+L++      A 
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ 1165

Query: 130  ADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEI 189
             ++R +  Q   +L+  L+      EA     +DM +   T +E+L +        L++ 
Sbjct: 1166 QELRTKREQEVAELKKALEEETKNHEAQI---QDMRQRHATALEELSEQ-------LEQA 1215

Query: 190  RSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA 249
            +    + E+   K+  E D+      + L   + K+L+++  E  + + ++     +L A
Sbjct: 1216 KRFKANLEK--NKQGLETDN------KELACEV-KVLQQVKAESEHKRKKLDAQVQELHA 1266

Query: 250  LKSESQN-KIELL-----LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEI 303
              SE    ++EL      LQ   D +  L+ E E +     + A+S  SQ   +Q   E+
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ---LQDTQEL 1323

Query: 304  IQEQARNQNSMYMRQLSDLESTVSQLRSE---LREAKRMYEDKTEELEKQLVLANSELTE 360
            +QE+ R        Q  +L S + QL  E   L+E +   E+  + LEKQ++   S+L +
Sbjct: 1324 LQEETR--------QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLAD 1375

Query: 361  ARTERDQFSQESGNLDDQLQKLLADLHKREKELS--------LEKEQNKRLWDRDTGNSI 412
             + + D       +L++  +KLL D     + L         LEK +N+   + D   ++
Sbjct: 1376 TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD-LTV 1434

Query: 413  TIDHLRRELDNRNMEVQRLEALLKALKS------------ECQGQMERQMA--------- 451
             +DH R+   N   + ++ + LL   KS            E + + +   A         
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494

Query: 452  AIQGKNESLEKVSSLTAQLE---STKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEK 508
            A++ K E   +   L A +E   S+K+ + K V EL   K  LE     + ++ T L+E 
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ---VEEMRTQLEEL 1551

Query: 509  ERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILR 568
            E  ++AT  E  KLR  V+++  + Q  ++        + +   L  Q+ E +  +E  R
Sbjct: 1552 EDELQAT--EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER 1609

Query: 569  QQ--------------IENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKD 614
            +Q              ++++   +    +    +  +  +L+ ++ D + EL+E +  +D
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD 1669

Query: 615  KKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSE 674
            +  A+ +E E ++  LE E ++L    +   RA +  +QERD+L +E+  S S  + L +
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 675  EYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQK 734
            E   L+       EE+E   + +++ L     +     +TL +   ++  A + +   ++
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMEL-LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ 1788

Query: 735  QITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEV 794
            Q+  +  +   L++K+Q LE A+   +K K  +   ++K+ Q    +  E  + A   ++
Sbjct: 1789 QLERQNKE---LKAKLQELEGAV--KSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843

Query: 795  LRSQERRLKEKVTNME----------VALDKASLQFAECQDIIQRQEQESVRL-----KL 839
            +R  E++LKE    +E            ++KA+ +  + +  ++  E+E+ R      KL
Sbjct: 1844 VRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903

Query: 840  QHTLDIKELQGPGYTSN-SSLKPRLLQPASVTRSHS 874
            Q  LD       G +   S+LK RL +   ++ S S
Sbjct: 1904 QRELDDATEANEGLSREVSTLKNRLRRGGPISFSSS 1939



 Score =  134 bits (338), Expect = 4e-31
 Identities = 184/968 (19%), Positives = 402/968 (41%), Gaps = 117/968 (12%)

Query: 80   LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKL-------QEMQMER-DAMAD 131
            LEE  H ++       E N++ + +K  ++  + DL+ +L       Q++Q+E+  A A 
Sbjct: 920  LEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979

Query: 132  IRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRS 191
            I++ E   +E L  + QN+    E  K L ED + + ++Q+ +  +   +   +  +   
Sbjct: 980  IKKME---EEILLLEDQNSKFIKE--KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034

Query: 192  ILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALK 251
            ++ D EE   K+                  + K  R+LD E + L+ +I  ++ Q++ LK
Sbjct: 1035 MISDLEERLKKE------------EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082

Query: 252  SESQNKIELLL---------QQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQME 302
             +   K E L            H++   +++ E + +I  L E   S ++  N  + Q  
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142

Query: 303  IIQEQARNQNSMYMRQLSDLESTVSQLRS----ELREAKRMYEDKTEELEKQLVLANSEL 358
             + E+     +  +    D  +   +LR+    E+ E K+  E++T+  E Q+       
Sbjct: 1143 DLSEELEALKT-ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201

Query: 359  TEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLR 418
              A  E  +  +++      L+K    L    KEL+ E +  +++          +D   
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261

Query: 419  RELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLR 478
            +EL  +  E  RL   L    S+ Q +++     ++   +   K +   A LES  +  +
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321

Query: 479  KVVEELTAKKMTLESSERTISDLTTSLQEK-----------ERAIEATNAEITKLRSRVD 527
            ++++E T +K+ L S  R + +   SLQE+           E+ + A  +++   + +VD
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381

Query: 528  LKLQELQHLKNEGDHLRNVQTECEALKLQMTEK-------DKVIEILRQQIENMTQLVGQ 580
              L  ++ L+   +  + +  + EAL  ++ EK       +K    L+Q+++++T  +  
Sbjct: 1382 DDLGTIESLE---EAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438

Query: 581  HGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNA 640
              + A  ++ ++ + ++ + + +         +D+ +A+ RE E +        + L  A
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA-------LSLARA 1491

Query: 641  GSERLRAVKDIKQERDQL---LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKL 697
              E L A ++ +++  QL   + ++ +S+ ++     E E  KR    + EEM     +L
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551

Query: 698  KMQLKS---AQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLE 754
            + +L++   A+  LE     +K+    D          +K++  K  Q+  L+++++   
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK--QVRELEAELEDER 1609

Query: 755  EAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALD 814
            +    A   K  ++ +   L  ++      ++++  +L  L++Q +  + ++     + D
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD 1669

Query: 815  KASLQFAECQ--------DIIQRQEQ-ESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQ 865
            +   Q  E +        +I+Q QE+  S     +H    ++      T+++S K  LL 
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 866  -----PASVTRSHSNVPSSQSTASFL------------------------SHHSTKANTL 896
                  A + +    +   QS    L                        +  S  A   
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789

Query: 897  KEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCH 956
             E   ++LK  LQEL   +  +   ++S  E      +G LE+++     E +  + +  
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFKATISALE----AKIGQLEEQLEQEAKERAAANKLVR 1845

Query: 957  RSNNSLRD 964
            R+   L++
Sbjct: 1846 RTEKKLKE 1853



 Score =  122 bits (306), Expect = 2e-27
 Identities = 156/761 (20%), Positives = 335/761 (44%), Gaps = 85/761 (11%)

Query: 147  LQNTVHELEAAKCLKEDMLK--DSNTQIE-QLRKMMLSHEGVLQEIRSILVDFEEASGKK 203
            LQ T  E E  +   E++LK  +  T++E +L +M   H+ +L+E ++IL +  +A  + 
Sbjct: 845  LQVTRQE-EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE-KNILAEQLQAETEL 902

Query: 204  ICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELL-- 261
              E + M      +    + +IL +L++ +   + R   ++++ + +++  Q+  E L  
Sbjct: 903  FAEAEEMRA-RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961

Query: 262  -------LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQ-------SQMEIIQEQ 307
                   LQ  +   E  I + E EI  L ++ S    +   ++       SQ+   +E+
Sbjct: 962  EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021

Query: 308  ARNQNSMYMRQ---LSDLESTVSQ---LRSELREAKRMYEDKTEELEKQLVLANSELTEA 361
            A+N   +  +Q   +SDLE  + +    R EL +AKR  + +T +L+ Q       + E 
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ-------IAEL 1074

Query: 362  RTERDQFSQESGNLDDQLQKLLA-----DLHKRE-----KELSLEKEQNKRLWDRDTGNS 411
            + + D+   +    +++LQ  LA      LHK       +EL  +  + +  ++ +  + 
Sbjct: 1075 QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134

Query: 412  ITIDHLRRELDNRNMEVQ-RLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQL 470
               +  +R+L      ++  LE  L    ++ + + +R+    + K    E+  +  AQ+
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194

Query: 471  ESTKEMLRKVVEELTAK-------KMTLESSERTISDLTTSLQEKERAIEATNAEITKLR 523
            +  ++     +EEL+ +       K  LE +++ +      L  + + ++   AE    R
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254

Query: 524  SRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGR 583
             ++D ++QEL    +EGD LR V+   +A KLQ             +++N++ L+ +  +
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLR-VELAEKASKLQ------------NELDNVSTLLEEAEK 1301

Query: 584  TAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSE 643
                   + A LE ++ D +  L+E    K    ++IR+LE   + L+ ++ +   A   
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361

Query: 644  RLRAV-------KDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKS---EEMEMT 693
              + V        D K++ D  L  +++       L ++ E L +    K+   +++E T
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421

Query: 694  TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAK------RGQIDA-- 745
             N+L+ +L     +L+  R    ++E          +  +K I+A+      R + +A  
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQ-KKFDQLLAEEKSISARYAEERDRAEAEARE 1480

Query: 746  LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEK 805
             ++K   L  A+  A + K   + +  +L  ++  + + K+ +   +  L   +R L+++
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ 1540

Query: 806  VTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIK 846
            V  M   L++   +    +D   R E     +K Q   D++
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 158/790 (20%), Positives = 328/790 (41%), Gaps = 92/790 (11%)

Query: 381  KLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE----LDNRNMEVQRLEALLK 436
            K L  + ++E+EL  + E+  ++ ++ T     ++ + R+    L+ +N+  ++L+A   
Sbjct: 842  KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA--- 898

Query: 437  ALKSECQGQMERQMAAIQGKNESLEKV-SSLTAQLESTKEMLRKVVEELTAKKMTLESSE 495
              ++E   + E   A +  K + LE++   L +++E  +E  R  + +   KKM     +
Sbjct: 899  --ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEE--RNQILQNEKKKM-----Q 949

Query: 496  RTISDLTTSLQEKERA-----IEATNAEITKLRSRVDLKLQELQHLK--NEGDHLRNVQT 548
              I DL   L E+E A     +E   AE    +   ++ L E Q+ K   E   + +   
Sbjct: 950  AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIA 1009

Query: 549  ECEALKLQMTEKDKVIEILRQQ----IENMTQLVGQHGRTAGAMQVEKAQLEKEINDRR- 603
            EC +   +  EK K +  +R +    I ++ + + +  +T   ++  K +L+ E  D + 
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD 1069

Query: 604  ------MELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQ 657
                   ++ ELK+   KK+ +++   AR  D  L K   +    E    + +++++ + 
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129

Query: 658  LLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKS 717
                   +  +  +LSEE E LK       + ++ T  + +++ K  Q E+ + +  L+ 
Sbjct: 1130 EKASRNKAEKQKRDLSEELEALKTEL---EDTLDTTAAQQELRTKREQ-EVAELKKALE- 1184

Query: 718  MEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQE 777
             E +  H  ++    Q+  TA    ++ L  +++  +    N  K K  L+ +  +L+ E
Sbjct: 1185 -EETKNHEAQIQDMRQRHATA----LEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239

Query: 778  LSTVATEK----------NKMAGELEVLRSQERRLK----EKVTNMEVALDKAS--LQFA 821
            +  +   K          +    EL    S+  RL+    EK + ++  LD  S  L+ A
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299

Query: 822  ECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQS 881
            E + I   ++  S+  +LQ   D +EL         +L  R+ Q      S       + 
Sbjct: 1300 EKKGIKFAKDAASLESQLQ---DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356

Query: 882  TA------SFLSHHSTKANTLK---------EDPTRDLKQLLQELRSVIN--EEPAVSLS 924
             A        L+  S  A+T K         E      K+LL++  ++    EE A++  
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416

Query: 925  KTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHA 984
            K E+        L+D   D   +  + S++  +     +   E    S   + E     A
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476

Query: 985  GDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKP 1044
              RE  +   +   A   +++  A   F    K+      L + +E  + S       K 
Sbjct: 1477 EAREKETKALSLARALEEALE--AKEEFERQNKQ------LRADMEDLMSSKDDV--GKN 1526

Query: 1045 IHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMI-RNQEKRIQK 1103
            +H  +  K +    +E       +L++ L++ +     L++  QAM +   R+ + R ++
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586

Query: 1104 VKDQEKMLLK 1113
             ++++++L+K
Sbjct: 1587 NEEKKRLLIK 1596


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  143 bits (361), Expect = 8e-34
 Identities = 206/989 (20%), Positives = 417/989 (42%), Gaps = 144/989 (14%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L+ K K  L Q V DL++ L++   E+    D+ R + + +
Sbjct: 1002 EAHQQALDDLQAEEDKVNSLN-KTKSKLEQQVEDLESSLEQ---EKKLRVDLERNKRKLE 1057

Query: 141  EDLRNQLQNTVHELEAAKCLKEDMLKDSN-------TQIEQLRKMMLSHEGVLQEIRSIL 193
             DL+   Q ++ +LE  K   ++ LK  +       +++E  + + L  +  ++E+++ +
Sbjct: 1058 GDLK-LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116

Query: 194  VDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSE 253
             + EE       E +  +        S  ++ L EL   +    G       Q+E  K  
Sbjct: 1117 EELEEE-----IEAERATRAKTEKQRSDYARELEELSERLEEAGG---VTSTQIELNKKR 1168

Query: 254  SQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNS 313
                ++L     +  +E+   +HE  +  L +K + + ++       ++ ++++   + S
Sbjct: 1169 EAEFLKL-----RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1223

Query: 314  MYMRQLSDLEST---VSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQ 370
             +  ++ DL S+   VS+ ++ L +  R  ED+  E   +       L+E  T++ +   
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283

Query: 371  ESGNLDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH----------- 416
            E+G L  QL++   +++ L + ++  + + E+ KR  + +      + H           
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL 1343

Query: 417  --------------LRRELDNRNMEV------------QRLEALLKALKSECQGQMERQM 450
                          L+R L   N EV            QR E L +A K   Q       
Sbjct: 1344 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ------- 1396

Query: 451  AAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKER 510
              +Q   E +E V++  A LE TK+ L+  VE+L      +   ER  S L  +L +K+R
Sbjct: 1397 -RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL------MVDVERANS-LAAALDKKQR 1448

Query: 511  AIEATNAE----ITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEI 566
              +   AE      + ++ ++  L+E + L  E   L+N   E       +  ++K +E 
Sbjct: 1449 NFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLE- 1507

Query: 567  LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEAR 626
              Q+I ++T+ + ++G+T   ++  + Q+E E  D ++ L+E +   + ++AKI  ++  
Sbjct: 1508 --QEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ-- 1563

Query: 627  VSDLELEKVKLVNAGSERLRAVKD--IKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFR 684
               LEL +VK   +  +R  A KD  I+Q +      V+T +S L     + EV  RN  
Sbjct: 1564 ---LELTQVK---SEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL-----DAEVRSRNEA 1612

Query: 685  NK-SEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGS-------DGHAMKVAMGMQKQI 736
             +  ++ME   N++++QL  A  +  +T   L+S++G           A++    +++Q+
Sbjct: 1613 IRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL 1672

Query: 737  TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATE-------KNKMA 789
                 + + LQ++++ L   +    + +   ++E    ++ +  + T+       K K+ 
Sbjct: 1673 AIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE 1732

Query: 790  GELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLK----------- 838
             +L  L+S+         N E    KA    A   + +++++  S  L+           
Sbjct: 1733 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1792

Query: 839  -LQHTLDIKE---LQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKAN 894
             LQH LD  E   L+G G      L+ R+ +             +  +   L  +  +  
Sbjct: 1793 DLQHRLDEAEQLALKG-GKKQIQKLETRIRELEFELEGEQK--KNTESVKGLRKYERRVK 1849

Query: 895  TLKEDPTRDLKQLLQELRSVIN--EEPAVSLSKTEEDGRTSLGALEDRVRDC---ITESS 949
             L      D K +L+ L+ +++  +    S  +  E+      A   + R     + E+ 
Sbjct: 1850 ELTYQSEEDRKNVLR-LQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE 1908

Query: 950  LRSDMCHRSNNSLRDSTEGSKSSETLSRE 978
             R+D+     N LR  T    SS  +  E
Sbjct: 1909 ERADIAESQVNKLRAKTRDFTSSRMVVHE 1937



 Score =  103 bits (257), Expect = 9e-22
 Identities = 201/973 (20%), Positives = 395/973 (40%), Gaps = 140/973 (14%)

Query: 228  ELDTEISYLKGRIFPVEDQL---EALKSESQNKIELLLQQHQD----------------- 267
            E + E++ +K      +D+L   EA + E + K+  L+Q+  D                 
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904

Query: 268  RIEQLIS---EHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLES 324
            R +QLI    + E +I  +TE+A         I +++   + +  ++ S   + + DLE 
Sbjct: 905  RCDQLIKAKFQLEAKIKEVTERAEDEEE----INAELTAKKRKLEDECSELKKDIDDLEL 960

Query: 325  TVSQLRSELREAKRMYEDKTEEL-------------EKQLVLANSE-LTEARTERDQ--- 367
            T++++  E    +   ++ TEEL             +K L  A+ + L + + E D+   
Sbjct: 961  TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS 1020

Query: 368  FSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRE--LDNRN 425
             ++    L+ Q++ L + L ++EK+L ++ E+NKR  + D         L +E  LD  N
Sbjct: 1021 LNKTKSKLEQQVEDLESSL-EQEKKLRVDLERNKRKLEGDL-------KLAQESILDLEN 1072

Query: 426  MEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELT 485
             + Q  E L K     CQ Q + +     G  +  +K+  L A++E       ++ EE+ 
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGL-QFQKKIKELQARIE-------ELEEEIE 1124

Query: 486  AKKMTLESSERTISDLTTSLQE-KERAIEATNAEITKLRSRVDLKLQELQHLKNEGD-HL 543
            A++ T   +E+  SD    L+E  ER  EA     T++      K +E + LK   D   
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELN---KKREAEFLKLRRDLEE 1181

Query: 544  RNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRR 603
              +Q E     L+    D V E L +QI+N+        R    ++ EK++ + EI+D  
Sbjct: 1182 ATLQHEAMVAALRKKHADSVAE-LGEQIDNLQ-------RVKQKLEKEKSEFKLEIDDLS 1233

Query: 604  MELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVK 663
              ++ +   K   +   R LE ++S+   +  ++  + SE       ++ E  +L  +++
Sbjct: 1234 SSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLE 1293

Query: 664  TSRSELNNLSEEYEVLKR---NFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEG 720
               S ++ LS   +   +     + + EE     N L   L+S++ + +  R   +  + 
Sbjct: 1294 EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE 1353

Query: 721  SDGHAMKVAMGMQKQITAKRG--QIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQEL 778
                  +       ++   R   + DA+Q + + LEEA     +     +E+   ++ + 
Sbjct: 1354 GKAELQRALSKANSEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQDSEEQVEAVNAKC 1412

Query: 779  STVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLK 838
            +++   K ++ GE+E L        E+  ++  ALDK    F +     + + +ES + +
Sbjct: 1413 ASLEKTKQRLQGEVEDLMVD----VERANSLAAALDKKQRNFDKVLAEWKTKCEES-QAE 1467

Query: 839  LQHTL-DIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLK 897
            L+ +L + + L    +   ++ +  L Q  +V R + N+   Q  A      +    T+ 
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL--EQEIADLTEQIAENGKTIH 1525

Query: 898  E-DPTR--------DLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITES 948
            E + +R        D++  L+E  + +  E A  L    E     L  ++  +   I E 
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE-----LTQVKSEIDRKIAEK 1580

Query: 949  SLRSDMCHRSNNSLRDSTEGSKSSETLSR-EPVTLHAGDREDPSGCFTFTSAASPSVKNS 1007
                +   R+     ++ + +  +E  SR E + L      D +      S A+     +
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAET 1640

Query: 1008 AS--RSFNSSPKKSPVH----------------------SLLTSSVEGSIGSTSQYRSAK 1043
                RS     K + +H                      +LL + VE    +  Q   A+
Sbjct: 1641 LKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERAR 1700

Query: 1044 PIHSSDSVKDSQSPPIETTGKTC-----RKLQNRLESLQTLVEDLQLKNQAMSSMIRNQE 1098
             +   + +  ++   +  T  T      +KL+  L  LQ+ VED        S   RN E
Sbjct: 1701 KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED-------ASRDARNAE 1753

Query: 1099 KRIQKVKDQEKML 1111
            ++ +K      M+
Sbjct: 1754 EKAKKAITDAAMM 1766



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 138/700 (19%), Positives = 295/700 (42%), Gaps = 62/700 (8%)

Query: 56   KYEVELDSPRKIIPSPGK-----EHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQ 110
            ++++E+D     + S  K     E   R LE+   + +     +  S      QK  L+ 
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283

Query: 111  SVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNT 170
               +L  +L+E +     ++  ++  +Q  E+L+ QL+    E   AK      L+ S  
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE----EENKAKNALAHALQSSRH 1339

Query: 171  QIEQLRKMMLSHEGVLQEIRSIL--VDFEEASGKKICEHDSMS-TLHFRSLGSAISKILR 227
              + LR+     +    E++  L   + E A  +   E D++  T         +++ L+
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399

Query: 228  ELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKA 287
            + + ++  +  +   +E   + L+ E ++     L    +R   L +  + +     +  
Sbjct: 1400 DSEEQVEAVNAKCASLEKTKQRLQGEVED-----LMVDVERANSLAAALDKKQRNFDKVL 1454

Query: 288  SSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEEL 347
            +  +++    Q+++E   +++R+ ++   +  +  E  + QL +  RE K + E +  +L
Sbjct: 1455 AEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL-EQEIADL 1513

Query: 348  EKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKE---LSLEKEQNKRLW 404
             +Q+      + E    R Q   E  ++   L++  A L   E +   + LE  Q K   
Sbjct: 1514 TEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEI 1573

Query: 405  DRDTGNSITIDHLRRELDNRNMEVQR-LEALLKALKSECQGQME--RQMAAIQGKNESLE 461
            DR       I     E++      QR +E +  AL +E + + E  R    ++G    +E
Sbjct: 1574 DR------KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIE 1627

Query: 462  -KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEIT 520
             ++S    Q   T + LR V  +L   ++ L+ + R   DL   L   ER      AE+ 
Sbjct: 1628 IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVE 1687

Query: 521  KLRSRVD-----LKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIEN-- 573
            +LR+ ++      KL E Q L +  + ++ + T+  +L     + +  +  L+ ++E+  
Sbjct: 1688 ELRATLEQTERARKLAE-QELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746

Query: 574  -------------------MTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKD 614
                               M + + +   T+  ++  K  LE+ + D +  L E + L  
Sbjct: 1747 RDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1806

Query: 615  KKDAK-IRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRS---ELN 670
            K   K I++LE R+ +LE E        +E ++ ++  ++   +L  + +  R     L 
Sbjct: 1807 KGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQ 1866

Query: 671  NLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQ 710
            +L ++ +V  ++++ ++EE +   N    + + AQ ELE+
Sbjct: 1867 DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEE 1906



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 110/533 (20%), Positives = 211/533 (39%), Gaps = 52/533 (9%)

Query: 590  VEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKL---VNAGSERLR 646
            ++ A+ EKE+   + E ++ K    K +AK +ELE ++  L  EK  L   V A SE L 
Sbjct: 841  LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL- 899

Query: 647  AVKDIKQERDQL----------LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNK 696
               D ++  DQL          + EV     +   ++ E    KR   ++  E++   + 
Sbjct: 900  --LDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957

Query: 697  LKMQLKSAQSELEQTRNTLKS----MEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQF 752
            L++ L   + E   T N +K+    + G D    K+    +    A +  +D LQ++   
Sbjct: 958  LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE--- 1014

Query: 753  LEEAMTNANKEKHFLKEE----KSKLSQELS---TVATEKNKMAGELEVLRSQERRLKEK 805
             E+ + + NK K  L+++    +S L QE      +   K K+ G+L++ +     L+  
Sbjct: 1015 -EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073

Query: 806  VTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQ 865
               ++  L K   ++  CQ  +Q + ++   L LQ    IKELQ         ++     
Sbjct: 1074 KQQLDERLKKKDFEY--CQ--LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129

Query: 866  PASVTRSHSN-------VPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEE 918
             A   +  S+       +      A  ++    + N  +E     L++ L+E  ++ +E 
Sbjct: 1130 RAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEE-ATLQHEA 1188

Query: 919  PAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEG-SKSSETLSR 977
               +L K   D    LG   D ++    +            + L  S E  SKS   L +
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248

Query: 978  EPVTLH------AGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEG 1031
               TL        G  E+     +  +     ++  A        +K  + S L+ S + 
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308

Query: 1032 SIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQ 1084
                T + +  + +   +  K++ +  ++++   C  L+ + E  Q    +LQ
Sbjct: 1309 FTQQTEELK--RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1359


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  141 bits (356), Expect = 3e-33
 Identities = 179/943 (18%), Positives = 387/943 (41%), Gaps = 82/943 (8%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L  K K  L Q V DL+  L++   E+    D+ R + + +
Sbjct: 1001 EAHQQALDDLQAEEDKVNTL-TKAKVKLEQQVDDLEGSLEQ---EKKVRMDLERAKRKLE 1056

Query: 141  EDLR------NQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILV 194
             DL+        L+N   +L+     K+  L   N +IE  + +    +  L+E+++ + 
Sbjct: 1057 GDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIE 1116

Query: 195  DFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSES 254
            + EE       E +  +      L S +S+ L E+   +    G          +++ E 
Sbjct: 1117 ELEEE-----LEAERTARAKVEKLRSDLSRELEEISERLEEAGG--------ATSVQIEM 1163

Query: 255  QNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSM 314
              K E   Q+ +  +E+   +HE     L +K + + ++       ++ ++++   + S 
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223

Query: 315  YMRQLSDLESTVSQL---RSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQE 371
            +  +L D+ S + Q+   ++ L +  R  ED+  E   +       + +  ++R +   E
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283

Query: 372  SGNLDDQL---QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH-----------L 417
            +G L  QL   + L++ L + +   + + E  KR  + +      + H           L
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343

Query: 418  RRELDNRNMEVQRLEALLKALKSE-CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEM 476
            R + +        L+ +L    SE  Q + + +  AIQ   E  E    L  +L+  +E 
Sbjct: 1344 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403

Query: 477  LRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAE---ITKLRSRVDLKLQEL 533
            +  V  + ++ + T    +  I DL   ++    A  A + +     K+ +    K +E 
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463

Query: 534  Q-HLKNEGDHLRNVQTECEALKLQMTEKDKVIEI-------LRQQIENMTQLVGQHGRTA 585
            Q  L++     R++ TE   LK    E  + +E        L+++I ++T+ +G  G+T 
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523

Query: 586  GAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERL 645
              ++  + QLE E  + +  L+E +   + ++ KI   +   + +   K ++    +E+ 
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI---KAEIERKLAEKD 1580

Query: 646  RAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQ 705
              ++  K+   ++++ ++TS         E   +K+       EME+  +        AQ
Sbjct: 1581 EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640

Query: 706  SELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKH 765
             +++  ++ LK  +     A++    +++ I     + + LQ++++ L   +    + + 
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK 1700

Query: 766  FLKEEKSKLSQEL-------STVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASL 818
              ++E  + S+ +       +++  +K KM  +L  L+++     ++  N E    KA  
Sbjct: 1701 LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAIT 1760

Query: 819  QFAECQDIIQRQEQESVRLK------------LQHTLDIKE---LQGPGYTSNSSLKPRL 863
              A   + +++++  S  L+            LQH LD  E   L+G G      L+ R+
Sbjct: 1761 DAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG-GKKQLQKLEARV 1819

Query: 864  LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAV-- 921
             +  +   +     +        S    K  T + +  R     LQ+L   +  +     
Sbjct: 1820 RELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYK 1879

Query: 922  -SLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
                + EE   T+L     +V+  + E+  R+D+     N LR
Sbjct: 1880 RQAEEAEEQANTNLSKFR-KVQHELDEAEERADIAESQVNKLR 1921



 Score =  133 bits (334), Expect = 1e-30
 Identities = 185/871 (21%), Positives = 372/871 (42%), Gaps = 132/871 (15%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADI 132
            K+  +  L++   ++  L  R+ +   L  +    L++ + +LQ +++E++ E +A    
Sbjct: 1073 KQQLDERLKKKDFELNALNARIEDEQALGSQ----LQKKLKELQARIEELEEELEAERTA 1128

Query: 133  RRRESQSQEDLRNQLQNTVHELE---AAKCLKEDMLKDSNTQIEQLRKMM----LSHEGV 185
            R +  + + DL  +L+     LE    A  ++ +M K    + +++R+ +    L HE  
Sbjct: 1129 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1188

Query: 186  LQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVED 245
               +R    D     G++I                 + ++ ++L+ E S  K  +  V  
Sbjct: 1189 AAALRKKHADSVAELGEQI---------------DNLQRVKQKLEKEKSEFKLELDDVTS 1233

Query: 246  QLEALKSESQNKIELLLQQHQDRIEQLISEHEV---EITGLTEKASSARSQANSIQSQM- 301
             +E +     N +E + +  +D++ +  S+ E     +  LT + +  +++   +  Q+ 
Sbjct: 1234 NMEQIIKAKAN-LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD 1292

Query: 302  --EIIQEQARNQNSMYMRQLSDLESTVSQ-------LRSELREAKR-------MYEDKTE 345
              E +  Q       Y +QL DL+  + +       L   L+ A+         YE++TE
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352

Query: 346  ---ELEKQLVLANSELTEARTERDQFS-QESGNLDDQLQKLLADLHKREKEL-------- 393
               EL++ L  ANSE+ + RT+ +  + Q +  L++  +KL   L + E+ +        
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412

Query: 394  SLEKEQNKRL---------WDRDTGNSITIDHLRR------------------ELDNRNM 426
            SLEK +++            +R    +  +D  +R                  EL++   
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472

Query: 427  EVQRLEALLKALKSECQGQMERQMAAIQGKNESL-EKVSSLTAQLES---TKEMLRKVVE 482
            E + L   L  LK+  +  +E  +   + +N++L E++S LT QL S   T   L KV +
Sbjct: 1473 EARSLSTELFKLKNAYEESLEH-LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRK 1531

Query: 483  ELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG-- 540
            +L A+KM L+S+   + +   SL+ +E  I     E  ++++ ++ KL E      +   
Sbjct: 1532 QLEAEKMELQSA---LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588

Query: 541  DHLR---NVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEK 597
            +HLR   ++QT  +A      E  +V + +   +  M   +    R A   Q +   L+ 
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQS 1648

Query: 598  EINDRRMELKELKILKD--KKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIK--- 652
             + D +++L +     D  K++  I E    +   ELE+++ V   +ER R + + +   
Sbjct: 1649 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1708

Query: 653  -QERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQT 711
              ER QLL+   TS   L N  ++ +      + + EE        + + K A ++    
Sbjct: 1709 TSERVQLLHSQNTS---LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM 1765

Query: 712  RNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEK 771
               LK  + +  H  ++   M++ I   + ++D  +      + A+    K+   L+   
Sbjct: 1766 AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE------QIALKGGKKQLQKLEARV 1819

Query: 772  SKLSQELSTVATEKNKMAGELEVLRSQERRLKE----------KVTNMEVALDKASLQF- 820
             +L  EL     E+ + A  ++ +R  ERR+KE           +  ++  +DK  L+  
Sbjct: 1820 RELENELE---AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK 1876

Query: 821  AECQDIIQRQEQESVRL----KLQHTLDIKE 847
            A  +   + +EQ +  L    K+QH LD  E
Sbjct: 1877 AYKRQAEEAEEQANTNLSKFRKVQHELDEAE 1907



 Score =  106 bits (265), Expect = 1e-22
 Identities = 178/911 (19%), Positives = 359/911 (39%), Gaps = 100/911 (10%)

Query: 243  VEDQLEALKSESQNKIELLLQQHQD-------RIEQLISEHEVEITGLTEKASSARSQAN 295
            +E+++ +L  E +N ++L +Q  QD       R +QLI ++++++    ++ +       
Sbjct: 873  LEEKMVSLLQE-KNDLQLQVQAEQDNLADAEERCDQLI-KNKIQLEAKVKEMNERLEDEE 930

Query: 296  SIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELE------K 349
             + +++   + +  ++ S   R + DLE T++++  E    +   ++ TEE+        
Sbjct: 931  EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 990

Query: 350  QLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG 409
            +L      L EA  +     Q   +  + L K    L ++  +L    EQ K++      
Sbjct: 991  KLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKV------ 1044

Query: 410  NSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQ 469
              + ++  +R+L+      Q     L+  K +   +++++   +   N  +E   +L +Q
Sbjct: 1045 -RMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQ 1103

Query: 470  LE-STKEM---LRKVVEELTAKKMTLESSERTISDLTTSLQE-KERAIEATNAEITKLRS 524
            L+   KE+   + ++ EEL A++      E+  SDL+  L+E  ER  EA  A  T ++ 
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA--TSVQI 1161

Query: 525  RVDLKLQ-ELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGR 583
             ++ K + E Q ++ + +    +Q E  A  L+    D V E L +QI+N+        R
Sbjct: 1162 EMNKKREAEFQKMRRDLEE-ATLQHEATAAALRKKHADSVAE-LGEQIDNLQ-------R 1212

Query: 584  TAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSE 643
                ++ EK++ + E++D    ++++   K   +   R LE ++++         +   E
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR-------SKAEE 1265

Query: 644  RLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKS 703
              R+V D+  +R +L    +T   EL+   +E E L                 LK QL+ 
Sbjct: 1266 TQRSVNDLTSQRAKL----QTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE- 1320

Query: 704  AQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSK-----IQFLEEAMT 758
               E  + +N L     S  H   +     ++ T  + ++  + SK      Q+  +  T
Sbjct: 1321 ---EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1377

Query: 759  NANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEV------- 811
            +A +    L+E K KL+Q L         +  +   L   + RL+ ++ ++ V       
Sbjct: 1378 DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1437

Query: 812  ---ALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPAS 868
               ALDK    F +     +++ +ES         + + L    +   ++ +  L    +
Sbjct: 1438 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1497

Query: 869  VTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEE 928
              R + N+    S  +     S K     E   + L+    EL+S + E  A   S   E
Sbjct: 1498 FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA---SLEHE 1554

Query: 929  DGRTSLGALE-----DRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLH 983
            +G+     LE       +   + E     +   R++  + DS + S  +ET SR      
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL-- 1612

Query: 984  AGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAK 1043
                                VK       N    +    + + +  +  + S        
Sbjct: 1613 -------------------RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653

Query: 1044 PIHSSDSVK--DSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRI 1101
             I   D+V+  D     I    +    LQ  LE L+ +VE  +   +     +    +R+
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1713

Query: 1102 QKVKDQEKMLL 1112
            Q +  Q   L+
Sbjct: 1714 QLLHSQNTSLI 1724



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 158/783 (20%), Positives = 319/783 (40%), Gaps = 106/783 (13%)

Query: 388  KREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQME 447
            +REKE++  KE+  RL +    +      L  ++ +   E   L+  ++A +       E
Sbjct: 844  EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903

Query: 448  RQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS----ERTISDLTT 503
            R    I+ K +   KV  +  +LE  +EM      ELTAKK  LE      +R I DL  
Sbjct: 904  RCDQLIKNKIQLEAKVKEMNERLEDEEEM----NAELTAKKRKLEDECSELKRDIDDLEL 959

Query: 504  SLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKV 563
            +L + E+   AT  ++  L   +    + +  L  E   L+  +   +AL     E+DKV
Sbjct: 960  TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ--EAHQQALDDLQAEEDKV 1017

Query: 564  IEI------LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN----------------D 601
              +      L QQ++++   + Q  +    ++  K +LE ++                 D
Sbjct: 1018 NTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD 1077

Query: 602  RRMELKELKI------------LKDKKDAKIRELEARVSDL--ELEKVKLVNAGSERLRA 647
             R++ K+ ++            L  +   K++EL+AR+ +L  ELE  +   A  E+LR+
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRS 1137

Query: 648  VKDIKQERDQLLNEVKTS------RSELNNLSE-EYEVLKRNFRNKSEEMEMTTNKLKMQ 700
              D+ +E +++   ++ +      + E+N   E E++ ++R+    + + E T   L+ +
Sbjct: 1138 --DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195

Query: 701  LKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNA 760
               + +EL +  + L+          +V   ++K+ +  + ++D + S ++ + +A  N 
Sbjct: 1196 HADSVAELGEQIDNLQ----------RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1245

Query: 761  NKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEV---ALDKAS 817
             K    L+++ ++   +        N +  +   L+++   L  ++   E     L +  
Sbjct: 1246 EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK 1305

Query: 818  LQFAECQDIIQRQEQESVRLK--LQHTLDIK----ELQGPGYTSNSSLKPRLLQPASVTR 871
            L + +  + ++RQ +E V+ K  L H L       +L    Y   +  K  L +  S   
Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1365

Query: 872  SHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVS--LSKTEED 929
            S          A + + + T A    E+     K+L Q L+       AV+   S  E+ 
Sbjct: 1366 S--------EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417

Query: 930  GRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDRED 989
                   +ED + D    ++  + +  +  N  +   E  +  E    E  +     R  
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1477

Query: 990  PSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSD 1049
             +  F   +A   S+++  +    +   +  +     S +   +GS     S K IH  +
Sbjct: 1478 STELFKLKNAYEESLEHLETFKRENKNLQEEI-----SDLTEQLGS-----SGKTIHELE 1527

Query: 1050 SV-KDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQ---LKNQAMSSMIRNQEKRIQKVK 1105
             V K  ++  +E        LQ+ LE  +  +E  +   L+ Q   + I+ + +R    K
Sbjct: 1528 KVRKQLEAEKME--------LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1579

Query: 1106 DQE 1108
            D+E
Sbjct: 1580 DEE 1582



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 98/531 (18%), Positives = 236/531 (44%), Gaps = 92/531 (17%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESN--------ELHEKQKFYLRQSVIDLQTKLQEMQM 124
            + +F+++L E+  + ++ Q  L  S         EL + +  Y  +S+  L+T  +E + 
Sbjct: 1446 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAY-EESLEHLETFKRENKN 1504

Query: 125  ERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIE----QLRKMML 180
             ++ ++D+  +   S + + ++L+    +LEA K   +  L+++   +E    ++ +  L
Sbjct: 1505 LQEEISDLTEQLGSSGKTI-HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563

Query: 181  SHEGVLQEIRSILVDFEEASGKKICEH----DSMST---LHFRSLGSAI------SKILR 227
                +  EI   L + +E   +    H    DS+ T      RS   A+         L 
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623

Query: 228  ELDTEISYLKGRIFPVEDQLEALKS---ESQNKIELLLQQHQD---------RIEQLISE 275
            E++ ++S+        + Q+++L+S   ++Q +++  ++ + D         R   L+  
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683

Query: 276  HEVEITGLTEKASSARSQANSIQSQMEIIQEQAR-----NQNSMYMRQLSDLESTVSQLR 330
               E+  + E+   +R  A     + E+I+   R     +QN+  + Q   +++ +SQL+
Sbjct: 1684 ELEELRAVVEQTERSRKLA-----EQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ 1738

Query: 331  SELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKRE 390
            +E+ EA +   +  E+ +K +  A     E + E+D  +         L+++  ++ +  
Sbjct: 1739 TEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA--------HLERMKKNMEQTI 1790

Query: 391  KELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQM 450
            K+L    ++ +++                 L     ++Q+LEA ++ L++E + + +R  
Sbjct: 1791 KDLQHRLDEAEQI----------------ALKGGKKQLQKLEARVRELENELEAEQKRNA 1834

Query: 451  AAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKER 510
             +++G  +S  ++  LT Q E  ++ L ++ + +   ++ +++ +R          + E 
Sbjct: 1835 ESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKR----------QAEE 1884

Query: 511  AIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKD 561
            A E  N  ++K R        ++QH  +E +   ++  E +  KL+   +D
Sbjct: 1885 AEEQANTNLSKFR--------KVQHELDEAEERADI-AESQVNKLRAKSRD 1926



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 79/379 (20%), Positives = 159/379 (41%), Gaps = 33/379 (8%)

Query: 590  VEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVK 649
            ++ A+ EKE+   + E   LK   +K +A+ +ELE ++  L  EK  L          + 
Sbjct: 840  LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLA 899

Query: 650  DIKQERDQLLN---EVKTSRSELNNLSEEYEVL-------KRNFRNKSEEMEMTTNKLKM 699
            D ++  DQL+    +++    E+N   E+ E +       KR   ++  E++   + L++
Sbjct: 900  DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLEL 959

Query: 700  QLKSAQSELEQTRNTLKS----MEGSDGHAMKVAMGMQKQITAKRGQIDALQS---KIQF 752
             L   + E   T N +K+    M G D    K+    +    A +  +D LQ+   K+  
Sbjct: 960  TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNT 1019

Query: 753  LEEAMTNANKEKHFLK---EEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNM 809
            L +A     ++   L+   E++ K+  +L      K K+ G+L++ +     L+     +
Sbjct: 1020 LTKAKVKLEQQVDDLEGSLEQEKKVRMDLERA---KRKLEGDLKLTQESIMDLENDKQQL 1076

Query: 810  EVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASV 869
            +  L K   +       I  ++++++  +LQ  L  KELQ         L+      A V
Sbjct: 1077 DERLKKKDFELNALNARI--EDEQALGSQLQKKL--KELQARIEELEEELEAERTARAKV 1132

Query: 870  TRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELR------SVINEEPAVSL 923
             +  S++       S     +  A +++ +  +  +   Q++R      ++ +E  A +L
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192

Query: 924  SKTEEDGRTSLGALEDRVR 942
             K   D    LG   D ++
Sbjct: 1193 RKKHADSVAELGEQIDNLQ 1211


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  140 bits (354), Expect = 5e-33
 Identities = 203/1012 (20%), Positives = 450/1012 (44%), Gaps = 138/1012 (13%)

Query: 78   RVLEEYSHQ---VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRR 134
            R+ EE + +   ++DL+  L +   + +     L++ ++ +QT +  M +ER+       
Sbjct: 195  RLTEELNKEATVIQDLKTELLQRPGIEDVA--VLKKELVQVQTLMDNMTLERE------- 245

Query: 135  RESQSQEDLRNQLQNTVHELEAA-KCLKEDMLK---DSNTQIEQLRKMMLSHEGVLQEIR 190
            RES+  +D   +LQ+     EA    L+ ++ K   +    +++L+K+  S   + Q+ +
Sbjct: 246  RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305

Query: 191  SILVDF-----------EEASGKKICEHDSMSTLHFRSLG--------SAISKILRELDT 231
            ++  +            E+ + + + + +  +TLH + L         SA    L  +  
Sbjct: 306  TLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365

Query: 232  EIS-------YLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLT 284
            E+S        LK  +  VE + + LK+E +      LQQ ++  EQ   + + EI  L 
Sbjct: 366  ELSEKGEATQKLKEELSEVETKYQHLKAEFKQ-----LQQQREEKEQHGLQLQSEINQLH 420

Query: 285  EKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKT 344
             K      Q      +++  ++ +  +     +Q++DL+  +S+L  +L+E      +  
Sbjct: 421  SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480

Query: 345  EELEK-------QLVLANS---ELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELS 394
             +L+K       Q  L  S   +L EA+ + +Q  ++ G+ D ++Q L A L K ++ +S
Sbjct: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 395  LEKEQNKRLWDR---DTGNSITIDHLRRELDNRNMEVQRLEALL-------KALKSECQG 444
            L +++ + L+ +     G +  ++ L+ +      +V +L   L       K  +     
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600

Query: 445  QMERQMA---AIQGKNESLE-KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT--- 497
            Q++ Q A   A Q +  SLE  V+ L +QL  +KE + ++  ++ AK   L S+E     
Sbjct: 601  QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660

Query: 498  -ISDLTTSLQEKERAIEATNAEITKLRSRVD---LKLQELQ--------HLKNEGDHLRN 545
              +DL   L   + A++    E+ K+ +++D    KLQ+ Q        HLK   +   +
Sbjct: 661  QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS 720

Query: 546  VQTECEALKLQM-----------TEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEK-- 592
            ++ + E L+ Q+             K++ ++ L+QQ +  T L  +    +  +++EK  
Sbjct: 721  LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780

Query: 593  ---AQLEKEINDRRMELKELKILKDKKDAKI--RELEARVSDLELEKVKLVNAGSERLRA 647
                +L+ +     +E  + K+ K +++ +I  ++ E    + +++  +L N     +  
Sbjct: 781  VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840

Query: 648  VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSE-------EMEMTTNKLKMQ 700
            ++ +K E++ L+ E+ T + +L+ +S+  +  K  F  +++       ++E T  +LK Q
Sbjct: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900

Query: 701  LK-SAQSELEQTRNTLKSMEGSD--GHAMKVAM-GMQKQITAKRGQIDALQSKIQFLEEA 756
            L+   ++ L++ +   KS+E      H +K+ +  MQ+Q+   +  +   + + Q L+  
Sbjct: 901  LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960

Query: 757  MTNANKEKHFLKEEKSKLSQELSTVATEK----NKMAGELEVLRSQERRLKEKVTNMEVA 812
            +    +     K++   L  EL     +K    NK+  +L     +    KEK++ ++  
Sbjct: 961  INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020

Query: 813  LDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRS 872
             +K+   F + Q     +E E +  +     D+K           S++ +L        S
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATR----QDLK-----------SVEEKLSLAQEDLIS 1065

Query: 873  HSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTE-EDGR 931
            + N   +Q+    +    T   TL++D  +  +QL +  +++ + +   SL + E  + +
Sbjct: 1066 NRNQIGNQN--KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123

Query: 932  TSLGALED-RVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTL 982
            + L  +E+ + R     + L  ++      S+++ T    + + L ++ + L
Sbjct: 1124 SKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175



 Score =  140 bits (354), Expect = 5e-33
 Identities = 226/1130 (20%), Positives = 469/1130 (41%), Gaps = 136/1130 (12%)

Query: 31   VSSIRGTIIENTSSAGTLTQVPFFPKYEVELDSPRKIIPSPGKEHFERVLEEYSHQVKDL 90
            +  ++ ++ E T    TLT+     + +      +    S  K++ +  L +     + L
Sbjct: 290  LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349

Query: 91   QRRLNESN--------ELHEKQKFY--LRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            Q RL+ S         EL EK +    L++ + +++TK Q ++ E   +   ++RE + Q
Sbjct: 350  QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ--QQREEKEQ 407

Query: 141  EDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKM----MLSHEGVLQEIRSILVDF 196
              L  QLQ+ +++L +     E  L +++ ++++ R++    ++  E  + +++  L   
Sbjct: 408  HGL--QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465

Query: 197  EEASGKKICEH-------DSMSTLHF--RSLGSAISKILRELDTEISYLKGRIFPVEDQ- 246
            EE   +K+          D     H   ++L  + +  LRE   ++  +  +I   + + 
Sbjct: 466  EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525

Query: 247  --LEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEII 304
              LEAL  +S+  I LL ++ +D   ++ +       G T   +  + + +++Q Q+  +
Sbjct: 526  QNLEALLQKSKENISLLEKEREDLYAKIQAGE-----GETAVLNQLQEKNHTLQEQVTQL 580

Query: 305  QEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTE 364
             E+ +NQ+  + +   +L   V + ++ LR A    +D+   LE  +   NS+L E++ +
Sbjct: 581  TEKLKNQSESHKQAQENLHDQVQEQKAHLRAA----QDRVLSLETSVNELNSQLNESKEK 636

Query: 365  RDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNR 424
              Q       LD Q+        K + EL L  E  K     D  N +  D  +  L ++
Sbjct: 637  VSQ-------LDIQI--------KAKTELLLSAEAAKTAQRADLQNHL--DTAQNALQDK 679

Query: 425  NMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEEL 484
              E+ ++   L  + ++ Q + E          E  EK  SL  + E  +  ++K+  + 
Sbjct: 680  QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739

Query: 485  TAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLR 544
               K    S E+ + DL    Q++ +         T+L  +++++ + +   + +   L+
Sbjct: 740  LEVKA---SKEQALQDL----QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD---LQ 789

Query: 545  NVQTECEALKLQMTEKDKVIEILRQQIENMTQLVG-QHGRTAGAMQVEKAQLEKEINDRR 603
                  E++K ++T++++  +IL+Q  E ++Q    QH      +Q    +L+K   ++ 
Sbjct: 790  KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849

Query: 604  MELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVK 663
              + EL  +KDK       L+   S+ E E  K          A+ D+++   +L ++++
Sbjct: 850  ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK-------GKAAILDLEKTCKELKHQLQ 902

Query: 664  TSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDG 723
                ++ N  +E + LK++   + E     +++LK++L S Q +L Q +NTLK  E  + 
Sbjct: 903  V---QMENTLKEQKELKKSLEKEKE----ASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955

Query: 724  HAMKVAMGMQKQITAKRGQIDALQSKIQF-----------LEEAMTNANKEKHFLKEEKS 772
                    +++    K+ QI+ALQ +++            L++ +T A +E    KE+ S
Sbjct: 956  QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKIS 1015

Query: 773  KL------SQE-LSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQD 825
             L      SQE    + ++      EL   R   + ++EK++  +  L     Q      
Sbjct: 1016 VLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK 1075

Query: 826  IIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASF 885
            +IQ  +     L+       ++LQ          K + L+   +    S +   +     
Sbjct: 1076 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR 1135

Query: 886  LSHHSTKAN---------TLKEDPT-RDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLG 935
                 TK N         ++KE    +D KQLL + +  +  + A SL    E  + +  
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGK-ADSLKAAVEQEKRNQQ 1194

Query: 936  ALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFT 995
             L+D+V+    E  L+ +   +         E    SE   +E   +     E+     T
Sbjct: 1195 ILKDQVKK--EEEELKKEFIEK---------EAKLHSEIKEKE---VGMKKHEENEAKLT 1240

Query: 996  FTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQ 1055
                A      +  + + SS ++       T  + G I             +  + +D +
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEA--------TVQNNQDER 1292

Query: 1056 SPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVK 1105
               +E     C K +  +E LQT V +LQ K    ++ ++   +  Q ++
Sbjct: 1293 RALLER----CLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338



 Score =  110 bits (275), Expect = 7e-24
 Identities = 164/819 (20%), Positives = 346/819 (42%), Gaps = 134/819 (16%)

Query: 243 VEDQLEALKSESQNKIELL--------LQQHQDRIEQLISEHEVEITGLTEKASSARSQA 294
           V+D   +LK E     EL         LQQ + + + L+++   E+  L ++   A+++ 
Sbjct: 92  VQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTEN 151

Query: 295 NSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLA 354
            +I+   ++ +++A    +    +++D++S   + RS LREA    E K   L ++L   
Sbjct: 152 FNIKQMKDLFEQKA----AQLATEIADIKSKYDEERS-LREAA---EQKVTRLTEEL--- 200

Query: 355 NSELTEARTERDQFSQESGNLDD--------QLQKLLADLH-KREKELSLEKEQNKRLWD 405
           N E T  +  + +  Q  G  D         Q+Q L+ ++  +RE+E    K++ K+L  
Sbjct: 201 NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260

Query: 406 RDTGNSITIDHLRRELDNRNMEV-------QRLEALLKALKSECQGQMERQMAAIQGKNE 458
           +   +  TI  LR EL     EV       Q+L++ +  L  + Q   E  +   Q   +
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320

Query: 459 SLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAE 518
             EK +  +   ++ +  L +   +    +  L +SE ++  +   L EK  A +    E
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380

Query: 519 ITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLV 578
           ++++ ++        QHLK E   L+  + E E   LQ+  + ++ ++  + +E   QL 
Sbjct: 381 LSEVETKY-------QHLKAEFKQLQQQREEKEQHGLQL--QSEINQLHSKLLETERQLG 431

Query: 579 GQHGRTAGAMQVEKAQLEKE-INDRRMELKELKILKDKKDAKIRELEARVSDL--ELEKV 635
             HGR       E+ QL  E + D+  ++ +L++   + + +++E     ++L  +L+K 
Sbjct: 432 EAHGRLK-----EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486

Query: 636 KLVNAGSERLR-----AVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEM 690
           K  +   + L+      +++ + + +Q+L ++     ++ NL    +  K N     +E 
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546

Query: 691 E-------------MTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQIT 737
           E                N+L+ +  + Q ++ Q    LK+   S   A +    +  Q+ 
Sbjct: 547 EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE---NLHDQVQ 603

Query: 738 AKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKL----------------------- 774
            ++  + A Q ++  LE ++   N + +  KE+ S+L                       
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663

Query: 775 ----------------SQELSTVATEKNKMAGELE-------VLRSQERRLKEKVTNMEV 811
                            QEL+ + T+ +++  +L+        L S  +  KEK  ++E 
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723

Query: 812 ALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTR 871
             +       E +  I++ E +S+ +K      +++LQ      N+ L+ R  + +    
Sbjct: 724 KTE-------ELEGQIKKLEADSLEVKASKEQALQDLQQQRQL-NTDLELRATELSKQLE 775

Query: 872 SHSNVPSSQSTASFLSHHSTKANTLKEDPTR--DLKQLLQELRSVINEEPAV---SLSKT 926
               + S  ST   L   S    ++K+  T+  + KQ+L++    +++E  +    L+  
Sbjct: 776 MEKEIVS--STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833

Query: 927 EEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDS 965
            +   T L  ++      +TE S   D   + ++SL++S
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 175/834 (20%), Positives = 346/834 (41%), Gaps = 112/834 (13%)

Query: 322  LESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQK 381
            L   V  L++ L+E K   E+  +ELEK   L   E        D  S E  +L+ QL++
Sbjct: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS-SAELQSLEQQLEE 146

Query: 382  LLADLHKREKELSLEKEQNKRLWDRDTGNSIT-IDHLRRELDNRNMEVQRLEALLKALKS 440
               +        +   +Q K L+++      T I  ++ + D      +  E  +  L  
Sbjct: 147  AQTE--------NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198

Query: 441  ECQGQMERQMAAIQG-KNESLEKVSSLTAQLESTKEMLRKVVEELTAK-KMTLESSERT- 497
            E    + ++   IQ  K E L++       +E    + +++V+  T    MTLE    + 
Sbjct: 199  E----LNKEATVIQDLKTELLQRPG-----IEDVAVLKKELVQVQTLMDNMTLERERESE 249

Query: 498  -ISDLTTSLQEKERAIEAT----NAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEA 552
             + D    LQ +  + EAT     +E+ K    V + +QELQ LK+  + L         
Sbjct: 250  KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL--------- 300

Query: 553  LKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKIL 612
                 T+K++ +       EN+ +            + +  +LE++ N+  +  K ++  
Sbjct: 301  -----TQKNQTLT------ENLLK-----------KEQDYTKLEEKHNEESVSKKNIQAT 338

Query: 613  KDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNL 672
              +KD   ++L++R+S  E    ++    SE+  A + +K+E    L+EV+T        
Sbjct: 339  LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE----LSEVET-------- 386

Query: 673  SEEYEVLKRNFRN---KSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVA 729
              +Y+ LK  F+    + EE E    +L+ ++    S+L +T   L    G      +++
Sbjct: 387  --KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444

Query: 730  MGMQKQITAKRGQIDALQSKIQFLEEAM----TNANKEKHFLKEEKSKLSQE--LSTVAT 783
                +++  K  Q+  LQ K+  LEE +    TN+ + +H L + K +  ++  L    T
Sbjct: 445  ---SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501

Query: 784  EKNKMA-GELEVLRSQERRLKEKVTNMEVALDKA----SLQFAECQDI---IQRQEQESV 835
             K + A  +LE +  Q     +K+ N+E  L K+    SL   E +D+   IQ  E E+ 
Sbjct: 502  AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561

Query: 836  RL----KLQHTLDIKELQGPGYTSNSSLKPRLLQPA---SVTRSHSNVPSSQSTASFLSH 888
             L    +  HTL  +  Q      N S   +  Q      V    +++ ++Q     L  
Sbjct: 562  VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621

Query: 889  HSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEE--DGRTSLGALEDRVRDCIT 946
               + N+   +    + QL  ++++      +   +KT +  D +  L   ++ ++D   
Sbjct: 622  SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681

Query: 947  ESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAG---DREDPSGCFTFTSAASPS 1003
            E +  +    +    L+D  E     E+  +E    +       E+  G      A S  
Sbjct: 682  ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741

Query: 1004 VKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVK-DSQSPPIETT 1062
            VK S  ++     ++  +++ L      +   + Q    K I SS  +    +S  +E+ 
Sbjct: 742  VKASKEQALQDLQQQRQLNTDLELR---ATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798

Query: 1063 GKTCRKLQNRLESL----QTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQEKMLL 1112
             +   K +   + L    +TL ++ +++++ +++ I+     +QKVK +++ L+
Sbjct: 799  KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  140 bits (352), Expect = 9e-33
 Identities = 156/796 (19%), Positives = 350/796 (43%), Gaps = 87/796 (10%)

Query: 80   LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ- 138
            L + + Q +++Q + +E  +  E+Q+      + +L+ K  ++  E++ + +  + E++ 
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQ-KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902

Query: 139  --SQEDLR-------NQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEI 189
                E++R        +L+  +HE+EA    +ED  +    + +++ + ML  E  L+E 
Sbjct: 903  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE- 961

Query: 190  RSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA 249
                   EEA+ +K+                 + K+  E   +I  L+  I  ++DQ   
Sbjct: 962  -------EEAARQKL----------------QLEKVTAE--AKIKKLEDEILVMDDQNNK 996

Query: 250  LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQAR 309
            L  E +     LL++    +   ++E E +   LT+  +   S  + ++ +++  +E++R
Sbjct: 997  LSKERK-----LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-EEKSR 1050

Query: 310  NQNSMYMRQL----SDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
             +     R+L    SD    ++ L++++ E K     K EEL+  L   + E+ +     
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 366  DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRN 425
             +  +  G++ D  + L ++   R K    +++  + L    T    T+D    + + R 
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170

Query: 426  MEVQRLEALLKAL-------KSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLR 478
               Q +  L KAL       +++ Q   ++   A++   E LE+     A L+  K+ L 
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230

Query: 479  KVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKN 538
            K   +L  +   L  +++ +      L+ + + +++  ++  + R+ ++ K+ +LQ   N
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ---N 1287

Query: 539  EGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598
            E + +  +  E E   +++    K +  L  Q+++  +L+ +  R    +  +  QLE+E
Sbjct: 1288 EVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344

Query: 599  INDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQL 658
             N  + +L E      + +AK + LE  +S L ++        S+  + ++D     + L
Sbjct: 1345 RNSLQDQLDE------EMEAK-QNLERHISTLNIQL-------SDSKKKLQDFASTVEAL 1390

Query: 659  LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSM 718
                K  + E+ NL+++YE     +    +++E T N+L+ +L     +L+  R  + ++
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446

Query: 719  EGSDGHAMKVAMGMQKQITAK------RGQIDA--LQSKIQFLEEAMTNANKEKHFLKEE 770
            E          +  +K I++K      R + +A   ++K   L  A+  A + K  L+  
Sbjct: 1447 EKKQ-RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 771  KSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQ 830
               L  E+  + + K+ +   +  L   +R L+ ++  M+  L++   +    +D   R 
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 831  EQESVRLKLQHTLDIK 846
            E     LK Q   D++
Sbjct: 1566 EVNMQALKGQFERDLQ 1581



 Score =  128 bits (322), Expect = 3e-29
 Identities = 188/975 (19%), Positives = 408/975 (41%), Gaps = 134/975 (13%)

Query: 94   LNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRES----------QSQEDL 143
            +++ N    K++  L + + DL T L E + +   +  ++ +            + +E  
Sbjct: 990  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 144  RNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK 203
            R +L+    +LE       + + D   QI +L+  +   E   +E+++ L   ++   +K
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQK 1106

Query: 204  ICEHDSMSTLHFRSLGSAISKILRELDTEISY---LKGRIFPVEDQLEALKSESQNKIEL 260
                 + +    R L   IS +  +LD+E +     + +   + ++LEALK+E ++ ++ 
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161

Query: 261  LLQQHQDRIEQLISEHEVEIT--GLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQ 318
               Q + R ++   E EV +    L E+  S  +Q   ++ +     E+   Q   + R 
Sbjct: 1162 TATQQELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218

Query: 319  LSDLESTVSQLRSE----------LREAKRMYEDKTEELEKQLVLANSELTEARTERDQF 368
             ++L+     L  E          L +AK+  E K ++LE Q+    S+ ++    R + 
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278

Query: 369  SQESGNLDDQLQKLLADLHKREKE----------LSLEKEQNKRLWDRDTGNSITIDHLR 418
            + +   L ++++ +   L++ E +          LS + +  + L   +T   + +    
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338

Query: 419  RELDN-RNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEML 477
            R+L+  RN    +L+  ++A K   +  +      +    + L+  +S    LE  K+  
Sbjct: 1339 RQLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397

Query: 478  RKVVEELTA----KKMTLESSERTIS-----------------DLTTSLQEKERAIEATN 516
            +K +E LT     K    +  E+T +                  L ++L++K+R  +   
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 517  AEITKLRSRV--DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENM 574
            AE   + S+   +    E +  + E   L   +   EAL+ +  E ++  ++L+ ++E++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDL 1516

Query: 575  TQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI-LKDKKDAKIRELEARVSDLELE 633
                   G+    ++  K  LE ++ + + +L+EL+  L+  +DAK+R LE  +  L+ +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQ 1575

Query: 634  KVKLVNAGSE-----RLRAVKDIKQERDQLLNEVK------TSRSELNNLSEEYEVLKRN 682
              + + A  E     R +  + + +   +L +E K       ++ +L    ++ E+   +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 683  FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742
                 EE      KL+ Q+K  Q ELE  R +   +          A   + +  AK  +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---------FATAKENEKKAKSLE 1686

Query: 743  IDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQ---- 798
             D +Q     L+E +  A + +     EK +L++EL++  + +N +  E   L ++    
Sbjct: 1687 ADLMQ-----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741

Query: 799  ERRLKEKVTNMEVALDKASLQFAECQDIIQR--------QEQESVRLKLQHTLDIKELQG 850
            E  L+E+  NME   D+      + + +           Q+ ES R +L+          
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--------- 1792

Query: 851  PGYTSNSSLKPRL--LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLL 908
                 N  L+ +L  ++ A  ++  S + + ++  + L     +    K+  T+ LKQ  
Sbjct: 1793 ----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848

Query: 909  QELRSVI-----NEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
            ++L+ ++       + A    +  E G   +  L+ ++ +   ES   +    +    L 
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908

Query: 964  DSTEGSKSSETLSRE 978
            ++TE   S+E + RE
Sbjct: 1909 EATE---SNEAMGRE 1920



 Score =  126 bits (317), Expect = 1e-28
 Identities = 179/958 (18%), Positives = 399/958 (41%), Gaps = 106/958 (11%)

Query: 77   ERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE 136
            + +L+E      +L     E       +K  L + + +++ +L+E +     +   R++ 
Sbjct: 889  KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948

Query: 137  SQSQEDLRNQLQN---TVHELEAAKCLKEDMLK----------DSNTQIEQLRKMMLSHE 183
            +Q   DL  QL+       +L+  K   E  +K          D N ++ + RK++   E
Sbjct: 949  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL---E 1005

Query: 184  GVLQEIRSILVDFEEAS---GKKICEHDSM-STLHFR-----SLGSAISKILRELDTEIS 234
              + ++ + L + EE +    K   +H+SM S L  R          + K+ R+L+ + S
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065

Query: 235  YLKGRIFPVEDQLEALK---SESQNKIELLLQQHQDRIEQ------LISEHEVEITGLTE 285
                +I  ++ Q+  LK   ++ + +++  L +  D I Q       I E E  I+ L E
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 286  KASSARSQANSIQSQMEIIQEQAR----------NQNSMYMRQLSDLESTVSQLRSELRE 335
               S R+  N  + Q   + E+            +  +      +  E  V+ L+  L E
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 336  AKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL 395
              R +E + +E+ ++   A  ELTE   + +QF +   NLD   Q             +L
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTE---QLEQFKRAKANLDKNKQ-------------TL 1229

Query: 396  EKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQG 455
            EKE N  L     G    +   ++E++++    ++LEA ++ L+S+C    ER  A +  
Sbjct: 1230 EKE-NADL----AGELRVLGQAKQEVEHKK---KKLEAQVQELQSKC-SDGERARAELND 1280

Query: 456  KNESLE-KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEA 514
            K   L+ +V S+T  L   +    K+ +++ +    L+ ++  + + T         +  
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 515  TNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEIL------- 567
               E   L+ ++D +++  Q+L+    H+  +  +    K ++ +    +E L       
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLER---HISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397

Query: 568  RQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARV 627
            +++IEN+TQ   +       ++  K +L++E++D  ++L   + L    + K R+ +  +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 628  SDLELEKVKLVNAGSERLRAVKDIKQERDQLLN------EVKTSRSELNNLSEEYEVLKR 681
            ++   EK        ER RA  + +++  + L+      E   ++ EL   ++  +    
Sbjct: 1458 AE---EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514

Query: 682  NFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRG 741
            +  +  +++    ++L+   ++ ++++E+ +  L+ +E          + ++  + A +G
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 742  QIDA-LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
            Q +  LQ++ +  EE      ++ H  + E     ++ +  A  K K+ G+L+ L   E 
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---EL 1631

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLK 860
            +    +   E A+ +     A+ +D  QR+ +++   + +     KE +    +  + L 
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690

Query: 861  PRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPA 920
                  A+  R+       +   +     S       +D  R L+  + +L   + EE  
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE-- 1748

Query: 921  VSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSRE 978
                      + ++ A+ DRVR    ++   S+      ++ + +    +  E  ++E
Sbjct: 1749 ----------QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796



 Score =  116 bits (291), Expect = 1e-25
 Identities = 194/941 (20%), Positives = 381/941 (40%), Gaps = 182/941 (19%)

Query: 31   VSSIRGTIIENTSSAGTLTQVP-----FFPKYEVELDSPRKIIPSPGKEHFERVLE---- 81
            +S +   + E    A  LT++         + EV L    K       E  +R LE    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDAS 1065

Query: 82   EYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE---SQ 138
            ++  Q+ DLQ ++ E      K++  L+ ++  L     E+  + +A+  IR  E   S 
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLD---DEIAQKNNALKKIRELEGHISD 1122

Query: 139  SQEDL----------RNQLQNTVHELEAAKCLKEDMLKDSNTQIE--------------- 173
             QEDL            Q ++   ELEA K   ED L  + TQ E               
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182

Query: 174  ----------QLRKMMLSHEGVLQEIRSILVDFEEASG-----KKICEHDSMSTL-HFRS 217
                      Q+++M   H   ++E+   L  F+ A       K+  E ++       R 
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242

Query: 218  LGSAISKI---LRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLIS 274
            LG A  ++    ++L+ ++  L+ +        E  ++E  +K+  L Q   + +  +++
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKC----SDGERARAELNDKVHKL-QNEVESVTGMLN 1297

Query: 275  EHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQN--SMYMRQLSD----------- 321
            E E +   L +  +S  SQ   +Q   E++QE+ R +   S  +RQL +           
Sbjct: 1298 EAEGKAIKLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354

Query: 322  -------LESTVSQLRSELREAKRMYED------KTEELEKQLVLANSELTEARTER--- 365
                   LE  +S L  +L ++K+  +D        EE +K+       LT+   E+   
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 366  -DQFSQESGNLDDQLQKLLADL-HKREKELSLEKEQNK----RLWDRDTGNSITIDHLRR 419
             D+  +    L  +L  L+ DL ++R+   +LEK+Q K       +++  +    +  R 
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474

Query: 420  ELDNRNMEVQRLEALLKALKS--ECQGQMERQMAAIQGKNESL----EKVSSLTAQLEST 473
            E + R  E + L +L +AL+   E + ++ER    ++ + E L    + V     +LE +
Sbjct: 1475 EAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533

Query: 474  KEMLRKVVEELTAKKMTLESSERTISDLTTSLQ--------EKERAIEATNAEITKLRSR 525
            K  L   +EE+  +   LE   +   D    L+        + ER ++A + +  + R +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 526  VDLKLQELQ----------------HLKNEGDHLRNVQTECEA--------------LKL 555
            +  +L E +                  K EGD L++++ + ++              L+ 
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLRKLQA 1652

Query: 556  QMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDK 615
            QM +  + +E  R   + +     ++ + A +++ +  QL++++       K+  + K++
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712

Query: 616  KDAKI--------------RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
               ++              R LEAR++ LE E  +           V+   Q+ +QL NE
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772

Query: 662  VKTSRS---ELNNLSEEYEVLKRNFRNKSEEME--------MTTNKLKMQLKSAQSELEQ 710
            + T RS   +  +  ++ E   +  R+K  EME         T   L+ ++   + ++EQ
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832

Query: 711  ----TRNTLKSMEGSDGHAMKVAMGMQ---KQITAKRGQIDALQSKIQFLEEAMTNANKE 763
                 +   KS++  D    ++ + ++   K     + Q +   ++++ L+  +  A +E
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892

Query: 764  KHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804
               +   + KL +EL         M  E+  L+S+ RR  E
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933



 Score =  115 bits (287), Expect = 3e-25
 Identities = 182/883 (20%), Positives = 379/883 (42%), Gaps = 122/883 (13%)

Query: 262  LQQHQD-RIEQLISEHEVEITG-LTEKASSARSQANSIQSQMEIIQEQA----RNQNSMY 315
            L++ +D +I  +I   +    G L  KA + R Q     + M++IQ       + +N  +
Sbjct: 778  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQ---LTAMKVIQRNCAAYLKLRNWQW 834

Query: 316  MRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL 375
             R  + ++  +   R E  E  +  ED+ ++ +++   A +EL E   +  Q ++E   L
Sbjct: 835  WRLFTKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892

Query: 376  DDQLQ---KLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLE 432
             +QLQ   +L A+  +    L+ +K++ + +          +  +   L+      Q+L+
Sbjct: 893  QEQLQAETELYAEAEEMRVRLAAKKQELEEI----------LHEMEARLEEEEDRGQQLQ 942

Query: 433  ALLKALKSEC---QGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKM 489
            A  K +  +    + Q+E + AA Q     LEKV++  A+++  ++ +  + ++      
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQ--KLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSK 999

Query: 490  TLESSERTISDLTTSLQEKERAIEATNAEITKLR-------SRVDLKL-------QELQH 535
              +  E  ISDLTT+L E+E   +     +TKL+       S ++++L       QEL+ 
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 536  LKN--EGD------HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGA 587
            LK   EGD       + ++Q +   LK+Q+ +K+   E L+  +  +   + Q       
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKK 1112

Query: 588  MQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA 647
            ++    +LE  I+D + +L   +  ++K + + R+L   +  L+ E    +++ + +   
Sbjct: 1113 IR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1165

Query: 648  VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNK-SEEMEMTTNKLKMQLKSAQS 706
             ++++ +R+Q   EV   +  L+  +  +E   +  R K ++ +E  T +L+ Q K A++
Sbjct: 1166 -QELRAKREQ---EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKA 1220

Query: 707  ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHF 766
             L++ + TL+         ++V    ++++  K+ +++A   ++Q L+   ++  + +  
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERARAE 1277

Query: 767  LKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDI 826
            L ++  KL  E+ +V    N+  G+                 +++A D ASL  ++ QD 
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKA----------------IKLAKDVASLS-SQLQDT 1320

Query: 827  IQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHS--NVPSSQSTAS 884
             Q   QE  R KL  +  +++L+    +    L   +    ++ R  S  N+  S S   
Sbjct: 1321 -QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 885  FLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDC 944
                 ST    L+E   R  K++  E  +   EE A +  K E+        L+D V D 
Sbjct: 1380 LQDFAST-VEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436

Query: 945  ITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSV 1004
              +  L S++  +     +   E    S   + E     A  RE  +   +   A   ++
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496

Query: 1005 KNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGK 1064
            +        +   K+ +  L++S                        KD     +    K
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSS------------------------KDDVGKNVHELEK 1532

Query: 1065 TCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
            + R L+ ++E ++T +E+L+ + QA        E  +Q +K Q
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  140 bits (352), Expect = 9e-33
 Identities = 156/796 (19%), Positives = 350/796 (43%), Gaps = 87/796 (10%)

Query: 80   LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ- 138
            L + + Q +++Q + +E  +  E+Q+      + +L+ K  ++  E++ + +  + E++ 
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQ-KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909

Query: 139  --SQEDLR-------NQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEI 189
                E++R        +L+  +HE+EA    +ED  +    + +++ + ML  E  L+E 
Sbjct: 910  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE- 968

Query: 190  RSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA 249
                   EEA+ +K+                 + K+  E   +I  L+  I  ++DQ   
Sbjct: 969  -------EEAARQKL----------------QLEKVTAE--AKIKKLEDEILVMDDQNNK 1003

Query: 250  LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQAR 309
            L  E +     LL++    +   ++E E +   LT+  +   S  + ++ +++  +E++R
Sbjct: 1004 LSKERK-----LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-EEKSR 1057

Query: 310  NQNSMYMRQL----SDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
             +     R+L    SD    ++ L++++ E K     K EEL+  L   + E+ +     
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 366  DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRN 425
             +  +  G++ D  + L ++   R K    +++  + L    T    T+D    + + R 
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177

Query: 426  MEVQRLEALLKAL-------KSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLR 478
               Q +  L KAL       +++ Q   ++   A++   E LE+     A L+  K+ L 
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237

Query: 479  KVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKN 538
            K   +L  +   L  +++ +      L+ + + +++  ++  + R+ ++ K+ +LQ   N
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ---N 1294

Query: 539  EGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598
            E + +  +  E E   +++    K +  L  Q+++  +L+ +  R    +  +  QLE+E
Sbjct: 1295 EVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351

Query: 599  INDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQL 658
             N  + +L E      + +AK + LE  +S L ++        S+  + ++D     + L
Sbjct: 1352 RNSLQDQLDE------EMEAK-QNLERHISTLNIQL-------SDSKKKLQDFASTVEAL 1397

Query: 659  LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSM 718
                K  + E+ NL+++YE     +    +++E T N+L+ +L     +L+  R  + ++
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453

Query: 719  EGSDGHAMKVAMGMQKQITAK------RGQIDA--LQSKIQFLEEAMTNANKEKHFLKEE 770
            E          +  +K I++K      R + +A   ++K   L  A+  A + K  L+  
Sbjct: 1454 EKKQ-RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 771  KSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQ 830
               L  E+  + + K+ +   +  L   +R L+ ++  M+  L++   +    +D   R 
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 831  EQESVRLKLQHTLDIK 846
            E     LK Q   D++
Sbjct: 1573 EVNMQALKGQFERDLQ 1588



 Score =  128 bits (322), Expect = 3e-29
 Identities = 188/975 (19%), Positives = 408/975 (41%), Gaps = 134/975 (13%)

Query: 94   LNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRES----------QSQEDL 143
            +++ N    K++  L + + DL T L E + +   +  ++ +            + +E  
Sbjct: 997  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 144  RNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK 203
            R +L+    +LE       + + D   QI +L+  +   E   +E+++ L   ++   +K
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQK 1113

Query: 204  ICEHDSMSTLHFRSLGSAISKILRELDTEISY---LKGRIFPVEDQLEALKSESQNKIEL 260
                 + +    R L   IS +  +LD+E +     + +   + ++LEALK+E ++ ++ 
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168

Query: 261  LLQQHQDRIEQLISEHEVEIT--GLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQ 318
               Q + R ++   E EV +    L E+  S  +Q   ++ +     E+   Q   + R 
Sbjct: 1169 TATQQELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225

Query: 319  LSDLESTVSQLRSE----------LREAKRMYEDKTEELEKQLVLANSELTEARTERDQF 368
             ++L+     L  E          L +AK+  E K ++LE Q+    S+ ++    R + 
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285

Query: 369  SQESGNLDDQLQKLLADLHKREKE----------LSLEKEQNKRLWDRDTGNSITIDHLR 418
            + +   L ++++ +   L++ E +          LS + +  + L   +T   + +    
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345

Query: 419  RELDN-RNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEML 477
            R+L+  RN    +L+  ++A K   +  +      +    + L+  +S    LE  K+  
Sbjct: 1346 RQLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404

Query: 478  RKVVEELTA----KKMTLESSERTIS-----------------DLTTSLQEKERAIEATN 516
            +K +E LT     K    +  E+T +                  L ++L++K+R  +   
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 517  AEITKLRSRV--DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENM 574
            AE   + S+   +    E +  + E   L   +   EAL+ +  E ++  ++L+ ++E++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDL 1523

Query: 575  TQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI-LKDKKDAKIRELEARVSDLELE 633
                   G+    ++  K  LE ++ + + +L+EL+  L+  +DAK+R LE  +  L+ +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQ 1582

Query: 634  KVKLVNAGSE-----RLRAVKDIKQERDQLLNEVK------TSRSELNNLSEEYEVLKRN 682
              + + A  E     R +  + + +   +L +E K       ++ +L    ++ E+   +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 683  FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742
                 EE      KL+ Q+K  Q ELE  R +   +          A   + +  AK  +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---------FATAKENEKKAKSLE 1693

Query: 743  IDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQ---- 798
             D +Q     L+E +  A + +     EK +L++EL++  + +N +  E   L ++    
Sbjct: 1694 ADLMQ-----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748

Query: 799  ERRLKEKVTNMEVALDKASLQFAECQDIIQR--------QEQESVRLKLQHTLDIKELQG 850
            E  L+E+  NME   D+      + + +           Q+ ES R +L+          
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--------- 1799

Query: 851  PGYTSNSSLKPRL--LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLL 908
                 N  L+ +L  ++ A  ++  S + + ++  + L     +    K+  T+ LKQ  
Sbjct: 1800 ----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

Query: 909  QELRSVI-----NEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
            ++L+ ++       + A    +  E G   +  L+ ++ +   ES   +    +    L 
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915

Query: 964  DSTEGSKSSETLSRE 978
            ++TE   S+E + RE
Sbjct: 1916 EATE---SNEAMGRE 1927



 Score =  126 bits (317), Expect = 1e-28
 Identities = 179/958 (18%), Positives = 399/958 (41%), Gaps = 106/958 (11%)

Query: 77   ERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE 136
            + +L+E      +L     E       +K  L + + +++ +L+E +     +   R++ 
Sbjct: 896  KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955

Query: 137  SQSQEDLRNQLQN---TVHELEAAKCLKEDMLK----------DSNTQIEQLRKMMLSHE 183
            +Q   DL  QL+       +L+  K   E  +K          D N ++ + RK++   E
Sbjct: 956  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL---E 1012

Query: 184  GVLQEIRSILVDFEEAS---GKKICEHDSM-STLHFR-----SLGSAISKILRELDTEIS 234
              + ++ + L + EE +    K   +H+SM S L  R          + K+ R+L+ + S
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 235  YLKGRIFPVEDQLEALK---SESQNKIELLLQQHQDRIEQ------LISEHEVEITGLTE 285
                +I  ++ Q+  LK   ++ + +++  L +  D I Q       I E E  I+ L E
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 286  KASSARSQANSIQSQMEIIQEQAR----------NQNSMYMRQLSDLESTVSQLRSELRE 335
               S R+  N  + Q   + E+            +  +      +  E  V+ L+  L E
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 336  AKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL 395
              R +E + +E+ ++   A  ELTE   + +QF +   NLD   Q             +L
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTE---QLEQFKRAKANLDKNKQ-------------TL 1236

Query: 396  EKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQG 455
            EKE N  L     G    +   ++E++++    ++LEA ++ L+S+C    ER  A +  
Sbjct: 1237 EKE-NADL----AGELRVLGQAKQEVEHKK---KKLEAQVQELQSKC-SDGERARAELND 1287

Query: 456  KNESLE-KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEA 514
            K   L+ +V S+T  L   +    K+ +++ +    L+ ++  + + T         +  
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 515  TNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEIL------- 567
               E   L+ ++D +++  Q+L+    H+  +  +    K ++ +    +E L       
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLER---HISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404

Query: 568  RQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARV 627
            +++IEN+TQ   +       ++  K +L++E++D  ++L   + L    + K R+ +  +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 628  SDLELEKVKLVNAGSERLRAVKDIKQERDQLLN------EVKTSRSELNNLSEEYEVLKR 681
            ++   EK        ER RA  + +++  + L+      E   ++ EL   ++  +    
Sbjct: 1465 AE---EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

Query: 682  NFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRG 741
            +  +  +++    ++L+   ++ ++++E+ +  L+ +E          + ++  + A +G
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 742  QIDA-LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
            Q +  LQ++ +  EE      ++ H  + E     ++ +  A  K K+ G+L+ L   E 
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---EL 1638

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLK 860
            +    +   E A+ +     A+ +D  QR+ +++   + +     KE +    +  + L 
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697

Query: 861  PRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPA 920
                  A+  R+       +   +     S       +D  R L+  + +L   + EE  
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE-- 1755

Query: 921  VSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSRE 978
                      + ++ A+ DRVR    ++   S+      ++ + +    +  E  ++E
Sbjct: 1756 ----------QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803



 Score =  116 bits (291), Expect = 1e-25
 Identities = 194/941 (20%), Positives = 381/941 (40%), Gaps = 182/941 (19%)

Query: 31   VSSIRGTIIENTSSAGTLTQVP-----FFPKYEVELDSPRKIIPSPGKEHFERVLE---- 81
            +S +   + E    A  LT++         + EV L    K       E  +R LE    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDAS 1072

Query: 82   EYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE---SQ 138
            ++  Q+ DLQ ++ E      K++  L+ ++  L     E+  + +A+  IR  E   S 
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLD---DEIAQKNNALKKIRELEGHISD 1129

Query: 139  SQEDL----------RNQLQNTVHELEAAKCLKEDMLKDSNTQIE--------------- 173
             QEDL            Q ++   ELEA K   ED L  + TQ E               
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189

Query: 174  ----------QLRKMMLSHEGVLQEIRSILVDFEEASG-----KKICEHDSMSTL-HFRS 217
                      Q+++M   H   ++E+   L  F+ A       K+  E ++       R 
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249

Query: 218  LGSAISKI---LRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLIS 274
            LG A  ++    ++L+ ++  L+ +        E  ++E  +K+  L Q   + +  +++
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKC----SDGERARAELNDKVHKL-QNEVESVTGMLN 1304

Query: 275  EHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQN--SMYMRQLSD----------- 321
            E E +   L +  +S  SQ   +Q   E++QE+ R +   S  +RQL +           
Sbjct: 1305 EAEGKAIKLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361

Query: 322  -------LESTVSQLRSELREAKRMYED------KTEELEKQLVLANSELTEARTER--- 365
                   LE  +S L  +L ++K+  +D        EE +K+       LT+   E+   
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 366  -DQFSQESGNLDDQLQKLLADL-HKREKELSLEKEQNK----RLWDRDTGNSITIDHLRR 419
             D+  +    L  +L  L+ DL ++R+   +LEK+Q K       +++  +    +  R 
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481

Query: 420  ELDNRNMEVQRLEALLKALKS--ECQGQMERQMAAIQGKNESL----EKVSSLTAQLEST 473
            E + R  E + L +L +AL+   E + ++ER    ++ + E L    + V     +LE +
Sbjct: 1482 EAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540

Query: 474  KEMLRKVVEELTAKKMTLESSERTISDLTTSLQ--------EKERAIEATNAEITKLRSR 525
            K  L   +EE+  +   LE   +   D    L+        + ER ++A + +  + R +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 526  VDLKLQELQ----------------HLKNEGDHLRNVQTECEA--------------LKL 555
            +  +L E +                  K EGD L++++ + ++              L+ 
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLRKLQA 1659

Query: 556  QMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDK 615
            QM +  + +E  R   + +     ++ + A +++ +  QL++++       K+  + K++
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719

Query: 616  KDAKI--------------RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
               ++              R LEAR++ LE E  +           V+   Q+ +QL NE
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779

Query: 662  VKTSRS---ELNNLSEEYEVLKRNFRNKSEEME--------MTTNKLKMQLKSAQSELEQ 710
            + T RS   +  +  ++ E   +  R+K  EME         T   L+ ++   + ++EQ
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 711  ----TRNTLKSMEGSDGHAMKVAMGMQ---KQITAKRGQIDALQSKIQFLEEAMTNANKE 763
                 +   KS++  D    ++ + ++   K     + Q +   ++++ L+  +  A +E
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899

Query: 764  KHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKE 804
               +   + KL +EL         M  E+  L+S+ RR  E
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940



 Score =  115 bits (287), Expect = 3e-25
 Identities = 182/883 (20%), Positives = 379/883 (42%), Gaps = 122/883 (13%)

Query: 262  LQQHQD-RIEQLISEHEVEITG-LTEKASSARSQANSIQSQMEIIQEQA----RNQNSMY 315
            L++ +D +I  +I   +    G L  KA + R Q     + M++IQ       + +N  +
Sbjct: 785  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQ---LTAMKVIQRNCAAYLKLRNWQW 841

Query: 316  MRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL 375
             R  + ++  +   R E  E  +  ED+ ++ +++   A +EL E   +  Q ++E   L
Sbjct: 842  WRLFTKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899

Query: 376  DDQLQ---KLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLE 432
             +QLQ   +L A+  +    L+ +K++ + +          +  +   L+      Q+L+
Sbjct: 900  QEQLQAETELYAEAEEMRVRLAAKKQELEEI----------LHEMEARLEEEEDRGQQLQ 949

Query: 433  ALLKALKSEC---QGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKM 489
            A  K +  +    + Q+E + AA Q     LEKV++  A+++  ++ +  + ++      
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQ--KLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSK 1006

Query: 490  TLESSERTISDLTTSLQEKERAIEATNAEITKLR-------SRVDLKL-------QELQH 535
              +  E  ISDLTT+L E+E   +     +TKL+       S ++++L       QEL+ 
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 536  LKN--EGD------HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGA 587
            LK   EGD       + ++Q +   LK+Q+ +K+   E L+  +  +   + Q       
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKK 1119

Query: 588  MQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA 647
            ++    +LE  I+D + +L   +  ++K + + R+L   +  L+ E    +++ + +   
Sbjct: 1120 IR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1172

Query: 648  VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNK-SEEMEMTTNKLKMQLKSAQS 706
             ++++ +R+Q   EV   +  L+  +  +E   +  R K ++ +E  T +L+ Q K A++
Sbjct: 1173 -QELRAKREQ---EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKA 1227

Query: 707  ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHF 766
             L++ + TL+         ++V    ++++  K+ +++A   ++Q L+   ++  + +  
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERARAE 1284

Query: 767  LKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDI 826
            L ++  KL  E+ +V    N+  G+                 +++A D ASL  ++ QD 
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKA----------------IKLAKDVASLS-SQLQDT 1327

Query: 827  IQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHS--NVPSSQSTAS 884
             Q   QE  R KL  +  +++L+    +    L   +    ++ R  S  N+  S S   
Sbjct: 1328 -QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 885  FLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDC 944
                 ST    L+E   R  K++  E  +   EE A +  K E+        L+D V D 
Sbjct: 1387 LQDFAST-VEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443

Query: 945  ITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSV 1004
              +  L S++  +     +   E    S   + E     A  RE  +   +   A   ++
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503

Query: 1005 KNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGK 1064
            +        +   K+ +  L++S                        KD     +    K
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSS------------------------KDDVGKNVHELEK 1539

Query: 1065 TCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
            + R L+ ++E ++T +E+L+ + QA        E  +Q +K Q
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  140 bits (352), Expect = 9e-33
 Identities = 156/796 (19%), Positives = 350/796 (43%), Gaps = 87/796 (10%)

Query: 80   LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ- 138
            L + + Q +++Q + +E  +  E+Q+      + +L+ K  ++  E++ + +  + E++ 
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQ-KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909

Query: 139  --SQEDLR-------NQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEI 189
                E++R        +L+  +HE+EA    +ED  +    + +++ + ML  E  L+E 
Sbjct: 910  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE- 968

Query: 190  RSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA 249
                   EEA+ +K+                 + K+  E   +I  L+  I  ++DQ   
Sbjct: 969  -------EEAARQKL----------------QLEKVTAE--AKIKKLEDEILVMDDQNNK 1003

Query: 250  LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQAR 309
            L  E +     LL++    +   ++E E +   LT+  +   S  + ++ +++  +E++R
Sbjct: 1004 LSKERK-----LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-EEKSR 1057

Query: 310  NQNSMYMRQL----SDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
             +     R+L    SD    ++ L++++ E K     K EEL+  L   + E+ +     
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 366  DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRN 425
             +  +  G++ D  + L ++   R K    +++  + L    T    T+D    + + R 
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177

Query: 426  MEVQRLEALLKAL-------KSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLR 478
               Q +  L KAL       +++ Q   ++   A++   E LE+     A L+  K+ L 
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237

Query: 479  KVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKN 538
            K   +L  +   L  +++ +      L+ + + +++  ++  + R+ ++ K+ +LQ   N
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ---N 1294

Query: 539  EGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598
            E + +  +  E E   +++    K +  L  Q+++  +L+ +  R    +  +  QLE+E
Sbjct: 1295 EVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351

Query: 599  INDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQL 658
             N  + +L E      + +AK + LE  +S L ++        S+  + ++D     + L
Sbjct: 1352 RNSLQDQLDE------EMEAK-QNLERHISTLNIQL-------SDSKKKLQDFASTVEAL 1397

Query: 659  LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSM 718
                K  + E+ NL+++YE     +    +++E T N+L+ +L     +L+  R  + ++
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453

Query: 719  EGSDGHAMKVAMGMQKQITAK------RGQIDA--LQSKIQFLEEAMTNANKEKHFLKEE 770
            E          +  +K I++K      R + +A   ++K   L  A+  A + K  L+  
Sbjct: 1454 EKKQ-RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 771  KSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQ 830
               L  E+  + + K+ +   +  L   +R L+ ++  M+  L++   +    +D   R 
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 831  EQESVRLKLQHTLDIK 846
            E     LK Q   D++
Sbjct: 1573 EVNMQALKGQFERDLQ 1588



 Score =  129 bits (324), Expect = 2e-29
 Identities = 191/987 (19%), Positives = 412/987 (41%), Gaps = 134/987 (13%)

Query: 94   LNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRES----------QSQEDL 143
            +++ N    K++  L + + DL T L E + +   +  ++ +            + +E  
Sbjct: 997  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 144  RNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK 203
            R +L+    +LE       + + D   QI +L+  +   E   +E+++ L   ++   +K
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQK 1113

Query: 204  ICEHDSMSTLHFRSLGSAISKILRELDTEISY---LKGRIFPVEDQLEALKSESQNKIEL 260
                 + +    R L   IS +  +LD+E +     + +   + ++LEALK+E ++ ++ 
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168

Query: 261  LLQQHQDRIEQLISEHEVEIT--GLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQ 318
               Q + R ++   E EV +    L E+  S  +Q   ++ +     E+   Q   + R 
Sbjct: 1169 TATQQELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225

Query: 319  LSDLESTVSQLRSE----------LREAKRMYEDKTEELEKQLVLANSELTEARTERDQF 368
             ++L+     L  E          L +AK+  E K ++LE Q+    S+ ++    R + 
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285

Query: 369  SQESGNLDDQLQKLLADLHKREKE----------LSLEKEQNKRLWDRDTGNSITIDHLR 418
            + +   L ++++ +   L++ E +          LS + +  + L   +T   + +    
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1345

Query: 419  RELDN-RNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEML 477
            R+L+  RN    +L+  ++A K   +  +      +    + L+  +S    LE  K+  
Sbjct: 1346 RQLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404

Query: 478  RKVVEELTA----KKMTLESSERTIS-----------------DLTTSLQEKERAIEATN 516
            +K +E LT     K    +  E+T +                  L ++L++K+R  +   
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 517  AEITKLRSRV--DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENM 574
            AE   + S+   +    E +  + E   L   +   EAL+ +  E ++  ++L+ ++E++
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDL 1523

Query: 575  TQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI-LKDKKDAKIRELEARVSDLELE 633
                   G+    ++  K  LE ++ + + +L+EL+  L+  +DAK+R LE  +  L+ +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQ 1582

Query: 634  KVKLVNAGSE-----RLRAVKDIKQERDQLLNEVK------TSRSELNNLSEEYEVLKRN 682
              + + A  E     R +  + + +   +L +E K       ++ +L    ++ E+   +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1642

Query: 683  FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742
                 EE      KL+ Q+K  Q ELE  R +   +          A   + +  AK  +
Sbjct: 1643 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---------FATAKENEKKAKSLE 1693

Query: 743  IDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQ---- 798
             D +Q     L+E +  A + +     EK +L++EL++  + +N +  E   L ++    
Sbjct: 1694 ADLMQ-----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748

Query: 799  ERRLKEKVTNMEVALDKASLQFAECQDIIQR--------QEQESVRLKLQHTLDIKELQG 850
            E  L+E+  NME   D+      + + +           Q+ ES R +L+          
Sbjct: 1749 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--------- 1799

Query: 851  PGYTSNSSLKPRL--LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLL 908
                 N  L+ +L  ++ A  ++  S + + ++  + L     +    K+  T+ LKQ  
Sbjct: 1800 ----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855

Query: 909  QELRSVI-----NEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
            ++L+ ++       + A    +  E G   +  L+ ++ +   ES   +    +    L 
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915

Query: 964  DSTEGSKSSETLSREPVTLHAGDREDP 990
            ++TE   S+E + RE   L +  R  P
Sbjct: 1916 EATE---SNEAMGREVNALKSKLRGPP 1939



 Score =  126 bits (317), Expect = 1e-28
 Identities = 179/958 (18%), Positives = 399/958 (41%), Gaps = 106/958 (11%)

Query: 77   ERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE 136
            + +L+E      +L     E       +K  L + + +++ +L+E +     +   R++ 
Sbjct: 896  KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955

Query: 137  SQSQEDLRNQLQN---TVHELEAAKCLKEDMLK----------DSNTQIEQLRKMMLSHE 183
            +Q   DL  QL+       +L+  K   E  +K          D N ++ + RK++   E
Sbjct: 956  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL---E 1012

Query: 184  GVLQEIRSILVDFEEAS---GKKICEHDSM-STLHFR-----SLGSAISKILRELDTEIS 234
              + ++ + L + EE +    K   +H+SM S L  R          + K+ R+L+ + S
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072

Query: 235  YLKGRIFPVEDQLEALK---SESQNKIELLLQQHQDRIEQ------LISEHEVEITGLTE 285
                +I  ++ Q+  LK   ++ + +++  L +  D I Q       I E E  I+ L E
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132

Query: 286  KASSARSQANSIQSQMEIIQEQAR----------NQNSMYMRQLSDLESTVSQLRSELRE 335
               S R+  N  + Q   + E+            +  +      +  E  V+ L+  L E
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192

Query: 336  AKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL 395
              R +E + +E+ ++   A  ELTE   + +QF +   NLD   Q             +L
Sbjct: 1193 ETRSHEAQVQEMRQKHAQAVEELTE---QLEQFKRAKANLDKNKQ-------------TL 1236

Query: 396  EKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQG 455
            EKE N  L     G    +   ++E++++    ++LEA ++ L+S+C    ER  A +  
Sbjct: 1237 EKE-NADL----AGELRVLGQAKQEVEHKK---KKLEAQVQELQSKC-SDGERARAELND 1287

Query: 456  KNESLE-KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEA 514
            K   L+ +V S+T  L   +    K+ +++ +    L+ ++  + + T         +  
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 515  TNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEIL------- 567
               E   L+ ++D +++  Q+L+    H+  +  +    K ++ +    +E L       
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLER---HISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404

Query: 568  RQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARV 627
            +++IEN+TQ   +       ++  K +L++E++D  ++L   + L    + K R+ +  +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 628  SDLELEKVKLVNAGSERLRAVKDIKQERDQLLN------EVKTSRSELNNLSEEYEVLKR 681
            ++   EK        ER RA  + +++  + L+      E   ++ EL   ++  +    
Sbjct: 1465 AE---EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

Query: 682  NFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRG 741
            +  +  +++    ++L+   ++ ++++E+ +  L+ +E          + ++  + A +G
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581

Query: 742  QIDA-LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
            Q +  LQ++ +  EE      ++ H  + E     ++ +  A  K K+ G+L+ L   E 
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---EL 1638

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLK 860
            +    +   E A+ +     A+ +D  QR+ +++   + +     KE +    +  + L 
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697

Query: 861  PRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPA 920
                  A+  R+       +   +     S       +D  R L+  + +L   + EE  
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE-- 1755

Query: 921  VSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSRE 978
                      + ++ A+ DRVR    ++   S+      ++ + +    +  E  ++E
Sbjct: 1756 ----------QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803



 Score =  115 bits (287), Expect = 3e-25
 Identities = 182/883 (20%), Positives = 379/883 (42%), Gaps = 122/883 (13%)

Query: 262  LQQHQD-RIEQLISEHEVEITG-LTEKASSARSQANSIQSQMEIIQEQA----RNQNSMY 315
            L++ +D +I  +I   +    G L  KA + R Q     + M++IQ       + +N  +
Sbjct: 785  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQ---LTAMKVIQRNCAAYLKLRNWQW 841

Query: 316  MRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL 375
             R  + ++  +   R E  E  +  ED+ ++ +++   A +EL E   +  Q ++E   L
Sbjct: 842  WRLFTKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899

Query: 376  DDQLQ---KLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLE 432
             +QLQ   +L A+  +    L+ +K++ + +          +  +   L+      Q+L+
Sbjct: 900  QEQLQAETELYAEAEEMRVRLAAKKQELEEI----------LHEMEARLEEEEDRGQQLQ 949

Query: 433  ALLKALKSEC---QGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKM 489
            A  K +  +    + Q+E + AA Q     LEKV++  A+++  ++ +  + ++      
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQ--KLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSK 1006

Query: 490  TLESSERTISDLTTSLQEKERAIEATNAEITKLR-------SRVDLKL-------QELQH 535
              +  E  ISDLTT+L E+E   +     +TKL+       S ++++L       QEL+ 
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 536  LKN--EGD------HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGA 587
            LK   EGD       + ++Q +   LK+Q+ +K+   E L+  +  +   + Q       
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKK 1119

Query: 588  MQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA 647
            ++    +LE  I+D + +L   +  ++K + + R+L   +  L+ E    +++ + +   
Sbjct: 1120 IR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1172

Query: 648  VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNK-SEEMEMTTNKLKMQLKSAQS 706
             ++++ +R+Q   EV   +  L+  +  +E   +  R K ++ +E  T +L+ Q K A++
Sbjct: 1173 -QELRAKREQ---EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKA 1227

Query: 707  ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHF 766
             L++ + TL+         ++V    ++++  K+ +++A   ++Q L+   ++  + +  
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERARAE 1284

Query: 767  LKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDI 826
            L ++  KL  E+ +V    N+  G+                 +++A D ASL  ++ QD 
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKA----------------IKLAKDVASLS-SQLQDT 1327

Query: 827  IQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHS--NVPSSQSTAS 884
             Q   QE  R KL  +  +++L+    +    L   +    ++ R  S  N+  S S   
Sbjct: 1328 -QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 885  FLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDC 944
                 ST    L+E   R  K++  E  +   EE A +  K E+        L+D V D 
Sbjct: 1387 LQDFAST-VEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443

Query: 945  ITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSV 1004
              +  L S++  +     +   E    S   + E     A  RE  +   +   A   ++
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503

Query: 1005 KNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGK 1064
            +        +   K+ +  L++S                        KD     +    K
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSS------------------------KDDVGKNVHELEK 1539

Query: 1065 TCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
            + R L+ ++E ++T +E+L+ + QA        E  +Q +K Q
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582



 Score =  114 bits (285), Expect = 5e-25
 Identities = 192/937 (20%), Positives = 379/937 (40%), Gaps = 182/937 (19%)

Query: 31   VSSIRGTIIENTSSAGTLTQVP-----FFPKYEVELDSPRKIIPSPGKEHFERVLE---- 81
            +S +   + E    A  LT++         + EV L    K       E  +R LE    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDAS 1072

Query: 82   EYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE---SQ 138
            ++  Q+ DLQ ++ E      K++  L+ ++  L     E+  + +A+  IR  E   S 
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLD---DEIAQKNNALKKIRELEGHISD 1129

Query: 139  SQEDL----------RNQLQNTVHELEAAKCLKEDMLKDSNTQIE--------------- 173
             QEDL            Q ++   ELEA K   ED L  + TQ E               
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189

Query: 174  ----------QLRKMMLSHEGVLQEIRSILVDFEEASG-----KKICEHDSMSTL-HFRS 217
                      Q+++M   H   ++E+   L  F+ A       K+  E ++       R 
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249

Query: 218  LGSAISKI---LRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLIS 274
            LG A  ++    ++L+ ++  L+ +        E  ++E  +K+  L Q   + +  +++
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKC----SDGERARAELNDKVHKL-QNEVESVTGMLN 1304

Query: 275  EHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQN--SMYMRQLSD----------- 321
            E E +   L +  +S  SQ   +Q   E++QE+ R +   S  +RQL +           
Sbjct: 1305 EAEGKAIKLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1361

Query: 322  -------LESTVSQLRSELREAKRMYED------KTEELEKQLVLANSELTEARTER--- 365
                   LE  +S L  +L ++K+  +D        EE +K+       LT+   E+   
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 366  -DQFSQESGNLDDQLQKLLADL-HKREKELSLEKEQNK----RLWDRDTGNSITIDHLRR 419
             D+  +    L  +L  L+ DL ++R+   +LEK+Q K       +++  +    +  R 
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481

Query: 420  ELDNRNMEVQRLEALLKALKS--ECQGQMERQMAAIQGKNESL----EKVSSLTAQLEST 473
            E + R  E + L +L +AL+   E + ++ER    ++ + E L    + V     +LE +
Sbjct: 1482 EAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540

Query: 474  KEMLRKVVEELTAKKMTLESSERTISDLTTSLQ--------EKERAIEATNAEITKLRSR 525
            K  L   +EE+  +   LE   +   D    L+        + ER ++A + +  + R +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 526  VDLKLQELQ----------------HLKNEGDHLRNVQTECEA--------------LKL 555
            +  +L E +                  K EGD L++++ + ++              L+ 
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLRKLQA 1659

Query: 556  QMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDK 615
            QM +  + +E  R   + +     ++ + A +++ +  QL++++       K+  + K++
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719

Query: 616  KDAKI--------------RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
               ++              R LEAR++ LE E  +           V+   Q+ +QL NE
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1779

Query: 662  VKTSRS---ELNNLSEEYEVLKRNFRNKSEEME--------MTTNKLKMQLKSAQSELEQ 710
            + T RS   +  +  ++ E   +  R+K  EME         T   L+ ++   + ++EQ
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839

Query: 711  ----TRNTLKSMEGSDGHAMKVAMGMQ---KQITAKRGQIDALQSKIQFLEEAMTNANKE 763
                 +   KS++  D    ++ + ++   K     + Q +   ++++ L+  +  A +E
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899

Query: 764  KHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
               +   + KL +EL         M  E+  L+S+ R
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  140 bits (352), Expect = 9e-33
 Identities = 156/796 (19%), Positives = 350/796 (43%), Gaps = 87/796 (10%)

Query: 80   LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ- 138
            L + + Q +++Q + +E  +  E+Q+      + +L+ K  ++  E++ + +  + E++ 
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQ-KAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902

Query: 139  --SQEDLR-------NQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEI 189
                E++R        +L+  +HE+EA    +ED  +    + +++ + ML  E  L+E 
Sbjct: 903  YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE- 961

Query: 190  RSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA 249
                   EEA+ +K+                 + K+  E   +I  L+  I  ++DQ   
Sbjct: 962  -------EEAARQKL----------------QLEKVTAE--AKIKKLEDEILVMDDQNNK 996

Query: 250  LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQAR 309
            L  E +     LL++    +   ++E E +   LT+  +   S  + ++ +++  +E++R
Sbjct: 997  LSKERK-----LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK-EEKSR 1050

Query: 310  NQNSMYMRQL----SDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
             +     R+L    SD    ++ L++++ E K     K EEL+  L   + E+ +     
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 366  DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRN 425
             +  +  G++ D  + L ++   R K    +++  + L    T    T+D    + + R 
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170

Query: 426  MEVQRLEALLKAL-------KSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLR 478
               Q +  L KAL       +++ Q   ++   A++   E LE+     A L+  K+ L 
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230

Query: 479  KVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKN 538
            K   +L  +   L  +++ +      L+ + + +++  ++  + R+ ++ K+ +LQ   N
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ---N 1287

Query: 539  EGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598
            E + +  +  E E   +++    K +  L  Q+++  +L+ +  R    +  +  QLE+E
Sbjct: 1288 EVESVTGMLNEAEGKAIKLA---KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344

Query: 599  INDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQL 658
             N  + +L E      + +AK + LE  +S L ++        S+  + ++D     + L
Sbjct: 1345 RNSLQDQLDE------EMEAK-QNLERHISTLNIQL-------SDSKKKLQDFASTVEAL 1390

Query: 659  LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSM 718
                K  + E+ NL+++YE     +    +++E T N+L+ +L     +L+  R  + ++
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446

Query: 719  EGSDGHAMKVAMGMQKQITAK------RGQIDA--LQSKIQFLEEAMTNANKEKHFLKEE 770
            E          +  +K I++K      R + +A   ++K   L  A+  A + K  L+  
Sbjct: 1447 EKKQ-RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 771  KSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQ 830
               L  E+  + + K+ +   +  L   +R L+ ++  M+  L++   +    +D   R 
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 831  EQESVRLKLQHTLDIK 846
            E     LK Q   D++
Sbjct: 1566 EVNMQALKGQFERDLQ 1581



 Score =  129 bits (324), Expect = 2e-29
 Identities = 191/987 (19%), Positives = 412/987 (41%), Gaps = 134/987 (13%)

Query: 94   LNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRES----------QSQEDL 143
            +++ N    K++  L + + DL T L E + +   +  ++ +            + +E  
Sbjct: 990  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 144  RNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK 203
            R +L+    +LE       + + D   QI +L+  +   E   +E+++ L   ++   +K
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQK 1106

Query: 204  ICEHDSMSTLHFRSLGSAISKILRELDTEISY---LKGRIFPVEDQLEALKSESQNKIEL 260
                 + +    R L   IS +  +LD+E +     + +   + ++LEALK+E ++ ++ 
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161

Query: 261  LLQQHQDRIEQLISEHEVEIT--GLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQ 318
               Q + R ++   E EV +    L E+  S  +Q   ++ +     E+   Q   + R 
Sbjct: 1162 TATQQELRAKR---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218

Query: 319  LSDLESTVSQLRSE----------LREAKRMYEDKTEELEKQLVLANSELTEARTERDQF 368
             ++L+     L  E          L +AK+  E K ++LE Q+    S+ ++    R + 
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278

Query: 369  SQESGNLDDQLQKLLADLHKREKE----------LSLEKEQNKRLWDRDTGNSITIDHLR 418
            + +   L ++++ +   L++ E +          LS + +  + L   +T   + +    
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL 1338

Query: 419  RELDN-RNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEML 477
            R+L+  RN    +L+  ++A K   +  +      +    + L+  +S    LE  K+  
Sbjct: 1339 RQLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397

Query: 478  RKVVEELTA----KKMTLESSERTIS-----------------DLTTSLQEKERAIEATN 516
            +K +E LT     K    +  E+T +                  L ++L++K+R  +   
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 517  AEITKLRSRV--DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENM 574
            AE   + S+   +    E +  + E   L   +   EAL+ +  E ++  ++L+ ++E++
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDL 1516

Query: 575  TQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI-LKDKKDAKIRELEARVSDLELE 633
                   G+    ++  K  LE ++ + + +L+EL+  L+  +DAK+R LE  +  L+ +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQ 1575

Query: 634  KVKLVNAGSE-----RLRAVKDIKQERDQLLNEVK------TSRSELNNLSEEYEVLKRN 682
              + + A  E     R +  + + +   +L +E K       ++ +L    ++ E+   +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADS 1635

Query: 683  FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742
                 EE      KL+ Q+K  Q ELE  R +   +          A   + +  AK  +
Sbjct: 1636 AIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---------FATAKENEKKAKSLE 1686

Query: 743  IDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQ---- 798
             D +Q     L+E +  A + +     EK +L++EL++  + +N +  E   L ++    
Sbjct: 1687 ADLMQ-----LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741

Query: 799  ERRLKEKVTNMEVALDKASLQFAECQDIIQR--------QEQESVRLKLQHTLDIKELQG 850
            E  L+E+  NME   D+      + + +           Q+ ES R +L+          
Sbjct: 1742 EEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER--------- 1792

Query: 851  PGYTSNSSLKPRL--LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLL 908
                 N  L+ +L  ++ A  ++  S + + ++  + L     +    K+  T+ LKQ  
Sbjct: 1793 ----QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848

Query: 909  QELRSVI-----NEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
            ++L+ ++       + A    +  E G   +  L+ ++ +   ES   +    +    L 
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908

Query: 964  DSTEGSKSSETLSREPVTLHAGDREDP 990
            ++TE   S+E + RE   L +  R  P
Sbjct: 1909 EATE---SNEAMGREVNALKSKLRGPP 1932



 Score =  126 bits (317), Expect = 1e-28
 Identities = 179/958 (18%), Positives = 399/958 (41%), Gaps = 106/958 (11%)

Query: 77   ERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE 136
            + +L+E      +L     E       +K  L + + +++ +L+E +     +   R++ 
Sbjct: 889  KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948

Query: 137  SQSQEDLRNQLQN---TVHELEAAKCLKEDMLK----------DSNTQIEQLRKMMLSHE 183
            +Q   DL  QL+       +L+  K   E  +K          D N ++ + RK++   E
Sbjct: 949  AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL---E 1005

Query: 184  GVLQEIRSILVDFEEAS---GKKICEHDSM-STLHFR-----SLGSAISKILRELDTEIS 234
              + ++ + L + EE +    K   +H+SM S L  R          + K+ R+L+ + S
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065

Query: 235  YLKGRIFPVEDQLEALK---SESQNKIELLLQQHQDRIEQ------LISEHEVEITGLTE 285
                +I  ++ Q+  LK   ++ + +++  L +  D I Q       I E E  I+ L E
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125

Query: 286  KASSARSQANSIQSQMEIIQEQAR----------NQNSMYMRQLSDLESTVSQLRSELRE 335
               S R+  N  + Q   + E+            +  +      +  E  V+ L+  L E
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185

Query: 336  AKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL 395
              R +E + +E+ ++   A  ELTE   + +QF +   NLD   Q             +L
Sbjct: 1186 ETRSHEAQVQEMRQKHAQAVEELTE---QLEQFKRAKANLDKNKQ-------------TL 1229

Query: 396  EKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQG 455
            EKE N  L     G    +   ++E++++    ++LEA ++ L+S+C    ER  A +  
Sbjct: 1230 EKE-NADL----AGELRVLGQAKQEVEHKK---KKLEAQVQELQSKC-SDGERARAELND 1280

Query: 456  KNESLE-KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEA 514
            K   L+ +V S+T  L   +    K+ +++ +    L+ ++  + + T         +  
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 515  TNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEIL------- 567
               E   L+ ++D +++  Q+L+    H+  +  +    K ++ +    +E L       
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLER---HISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397

Query: 568  RQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARV 627
            +++IEN+TQ   +       ++  K +L++E++D  ++L   + L    + K R+ +  +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 628  SDLELEKVKLVNAGSERLRAVKDIKQERDQLLN------EVKTSRSELNNLSEEYEVLKR 681
            ++   EK        ER RA  + +++  + L+      E   ++ EL   ++  +    
Sbjct: 1458 AE---EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514

Query: 682  NFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRG 741
            +  +  +++    ++L+   ++ ++++E+ +  L+ +E          + ++  + A +G
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574

Query: 742  QIDA-LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
            Q +  LQ++ +  EE      ++ H  + E     ++ +  A  K K+ G+L+ L   E 
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL---EL 1631

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLK 860
            +    +   E A+ +     A+ +D  QR+ +++   + +     KE +    +  + L 
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690

Query: 861  PRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPA 920
                  A+  R+       +   +     S       +D  R L+  + +L   + EE  
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE-- 1748

Query: 921  VSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSRE 978
                      + ++ A+ DRVR    ++   S+      ++ + +    +  E  ++E
Sbjct: 1749 ----------QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796



 Score =  115 bits (287), Expect = 3e-25
 Identities = 182/883 (20%), Positives = 379/883 (42%), Gaps = 122/883 (13%)

Query: 262  LQQHQD-RIEQLISEHEVEITG-LTEKASSARSQANSIQSQMEIIQEQA----RNQNSMY 315
            L++ +D +I  +I   +    G L  KA + R Q     + M++IQ       + +N  +
Sbjct: 778  LEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQ---LTAMKVIQRNCAAYLKLRNWQW 834

Query: 316  MRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL 375
             R  + ++  +   R E  E  +  ED+ ++ +++   A +EL E   +  Q ++E   L
Sbjct: 835  WRLFTKVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892

Query: 376  DDQLQ---KLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLE 432
             +QLQ   +L A+  +    L+ +K++ + +          +  +   L+      Q+L+
Sbjct: 893  QEQLQAETELYAEAEEMRVRLAAKKQELEEI----------LHEMEARLEEEEDRGQQLQ 942

Query: 433  ALLKALKSEC---QGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKM 489
            A  K +  +    + Q+E + AA Q     LEKV++  A+++  ++ +  + ++      
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQ--KLQLEKVTA-EAKIKKLEDEILVMDDQNNKLSK 999

Query: 490  TLESSERTISDLTTSLQEKERAIEATNAEITKLR-------SRVDLKL-------QELQH 535
              +  E  ISDLTT+L E+E   +     +TKL+       S ++++L       QEL+ 
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAK----NLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 536  LKN--EGD------HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGA 587
            LK   EGD       + ++Q +   LK+Q+ +K+   E L+  +  +   + Q       
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE---EELQAALARLDDEIAQKNNALKK 1112

Query: 588  MQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA 647
            ++    +LE  I+D + +L   +  ++K + + R+L   +  L+ E    +++ + +   
Sbjct: 1113 IR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ--- 1165

Query: 648  VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNK-SEEMEMTTNKLKMQLKSAQS 706
             ++++ +R+Q   EV   +  L+  +  +E   +  R K ++ +E  T +L+ Q K A++
Sbjct: 1166 -QELRAKREQ---EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE-QFKRAKA 1220

Query: 707  ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHF 766
             L++ + TL+         ++V    ++++  K+ +++A   ++Q L+   ++  + +  
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA---QVQELQSKCSDGERARAE 1277

Query: 767  LKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDI 826
            L ++  KL  E+ +V    N+  G+                 +++A D ASL  ++ QD 
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKA----------------IKLAKDVASLS-SQLQDT 1320

Query: 827  IQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHS--NVPSSQSTAS 884
             Q   QE  R KL  +  +++L+    +    L   +    ++ R  S  N+  S S   
Sbjct: 1321 -QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 885  FLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDC 944
                 ST    L+E   R  K++  E  +   EE A +  K E+        L+D V D 
Sbjct: 1380 LQDFAST-VEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436

Query: 945  ITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSV 1004
              +  L S++  +     +   E    S   + E     A  RE  +   +   A   ++
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496

Query: 1005 KNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGK 1064
            +        +   K+ +  L++S                        KD     +    K
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSS------------------------KDDVGKNVHELEK 1532

Query: 1065 TCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
            + R L+ ++E ++T +E+L+ + QA        E  +Q +K Q
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575



 Score =  114 bits (285), Expect = 5e-25
 Identities = 192/937 (20%), Positives = 379/937 (40%), Gaps = 182/937 (19%)

Query: 31   VSSIRGTIIENTSSAGTLTQVP-----FFPKYEVELDSPRKIIPSPGKEHFERVLE---- 81
            +S +   + E    A  LT++         + EV L    K       E  +R LE    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK--SRQELEKLKRKLEGDAS 1065

Query: 82   EYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE---SQ 138
            ++  Q+ DLQ ++ E      K++  L+ ++  L     E+  + +A+  IR  E   S 
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLD---DEIAQKNNALKKIRELEGHISD 1122

Query: 139  SQEDL----------RNQLQNTVHELEAAKCLKEDMLKDSNTQIE--------------- 173
             QEDL            Q ++   ELEA K   ED L  + TQ E               
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182

Query: 174  ----------QLRKMMLSHEGVLQEIRSILVDFEEASG-----KKICEHDSMSTL-HFRS 217
                      Q+++M   H   ++E+   L  F+ A       K+  E ++       R 
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242

Query: 218  LGSAISKI---LRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLIS 274
            LG A  ++    ++L+ ++  L+ +        E  ++E  +K+  L Q   + +  +++
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKC----SDGERARAELNDKVHKL-QNEVESVTGMLN 1297

Query: 275  EHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQN--SMYMRQLSD----------- 321
            E E +   L +  +S  SQ   +Q   E++QE+ R +   S  +RQL +           
Sbjct: 1298 EAEGKAIKLAKDVASLSSQ---LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE 1354

Query: 322  -------LESTVSQLRSELREAKRMYED------KTEELEKQLVLANSELTEARTER--- 365
                   LE  +S L  +L ++K+  +D        EE +K+       LT+   E+   
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 366  -DQFSQESGNLDDQLQKLLADL-HKREKELSLEKEQNK----RLWDRDTGNSITIDHLRR 419
             D+  +    L  +L  L+ DL ++R+   +LEK+Q K       +++  +    +  R 
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474

Query: 420  ELDNRNMEVQRLEALLKALKS--ECQGQMERQMAAIQGKNESL----EKVSSLTAQLEST 473
            E + R  E + L +L +AL+   E + ++ER    ++ + E L    + V     +LE +
Sbjct: 1475 EAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533

Query: 474  KEMLRKVVEELTAKKMTLESSERTISDLTTSLQ--------EKERAIEATNAEITKLRSR 525
            K  L   +EE+  +   LE   +   D    L+        + ER ++A + +  + R +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 526  VDLKLQELQ----------------HLKNEGDHLRNVQTECEA--------------LKL 555
            +  +L E +                  K EGD L++++ + ++              L+ 
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLRKLQA 1652

Query: 556  QMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDK 615
            QM +  + +E  R   + +     ++ + A +++ +  QL++++       K+  + K++
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712

Query: 616  KDAKI--------------RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
               ++              R LEAR++ LE E  +           V+   Q+ +QL NE
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772

Query: 662  VKTSRS---ELNNLSEEYEVLKRNFRNKSEEME--------MTTNKLKMQLKSAQSELEQ 710
            + T RS   +  +  ++ E   +  R+K  EME         T   L+ ++   + ++EQ
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832

Query: 711  ----TRNTLKSMEGSDGHAMKVAMGMQ---KQITAKRGQIDALQSKIQFLEEAMTNANKE 763
                 +   KS++  D    ++ + ++   K     + Q +   ++++ L+  +  A +E
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892

Query: 764  KHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
               +   + KL +EL         M  E+  L+S+ R
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  138 bits (347), Expect = 3e-32
 Identities = 189/835 (22%), Positives = 351/835 (42%), Gaps = 105/835 (12%)

Query: 80   LEEYSHQVKDLQRRLNESNELHEK--QKFYLRQSVIDLQTKLQEMQMERDAMADIRRRES 137
            LE    +++D         EL  K  Q+  + +  ++ + K  E Q++     ++R++ S
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ-----EMRQKHS 1195

Query: 138  QSQEDLRNQLQNTVH---ELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILV 194
            Q+ E+L  QL+ T      LE AK      L++   ++    K++L  +G  +  R  + 
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAK----QTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251

Query: 195  DFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSES 254
               +    K  E + + T     L   ++K+  ELD     L         Q ++  S+ 
Sbjct: 1252 AQLQELQVKFNEGERVRT----ELADKVTKLQVELDNVTGLLS--------QSDSKSSKL 1299

Query: 255  QNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSM 314
                  L  Q QD  ++L+ E   +   L+ K      + NS + Q+E  +E   N    
Sbjct: 1300 TKDFSALESQLQDT-QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE-- 1356

Query: 315  YMRQLSDLESTVSQLRSELREAKRMYEDKTE---ELEKQLVLANSELTEARTERDQFSQE 371
              +Q++ L + V+ ++ ++ ++    E   E   +L+K L   +    E     D+  + 
Sbjct: 1357 --KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414

Query: 372  SGNLDDQLQKLLADL-HKREKELSLEKEQNKRLWDRDTGNSITID-HLRRELDNRNMEVQ 429
               L  +L  LL DL H+R+   +LEK+Q K  +D+      TI      E D    E +
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKK--FDQLLAEEKTISAKYAEERDRAEAEAR 1472

Query: 430  RLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKM 489
              E    +L    +  ME Q A ++  N+           L S+K+ + K V EL   K 
Sbjct: 1473 EKETKALSLARALEEAME-QKAELERLNKQFRTEME---DLMSSKDDVGKSVHELEKSKR 1528

Query: 490  TLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTE 549
             LE     + ++ T L+E E  ++AT  E  KLR  V+L+  + Q  ++        + +
Sbjct: 1529 ALEQQ---VEEMKTQLEELEDELQAT--EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEK 1583

Query: 550  CEALKLQMTEKDKVIEILRQQ--------------IENMTQLVGQHGRTAGAMQVEKAQL 595
             + L  Q+ E +  +E  R+Q              ++++   +    +       +  +L
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643

Query: 596  EKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQER 655
            + ++ D   EL + +  +++  A+ +E E ++  +E E ++L    +   RA +  +QER
Sbjct: 1644 QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703

Query: 656  DQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEM---TTNKLKMQLKSAQSELEQTR 712
            D+L +E+  S  +     EE   L+       EE+E     T  +  +LK A  +++Q  
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI- 1762

Query: 713  NTLKSMEGSDGHAMKVAMGMQ------KQITAK------------RGQIDALQSKIQFLE 754
            NT  ++E S  HA K     Q      K++  K            +  I AL++KI  LE
Sbjct: 1763 NTDLNLERS--HAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE 1820

Query: 755  EAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALD 814
            E + N  KE+    ++  +  ++L  V  + +            ERR  E+  +     D
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKDVLLQVD-----------DERRNAEQYKDQ---AD 1866

Query: 815  KASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSN------SSLKPRL 863
            KAS +  + +  ++  E+E+ R         +EL+    T++      SSLK +L
Sbjct: 1867 KASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score =  133 bits (334), Expect = 1e-30
 Identities = 210/1034 (20%), Positives = 415/1034 (40%), Gaps = 115/1034 (11%)

Query: 115  LQTKLQEMQMERDAMADIRRRESQ-SQEDLRNQLQNTVHELEAAKCLKEDMLKDSN---T 170
            LQ   QE +M       ++ RE Q + E+   +++    +L A K   ++ L+       
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897

Query: 171  QIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELD 230
            + E+LR  + + +  L+EI   L    E   ++ C+H        +     + + L E +
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEARVEEEEER-CQHLQAEKKKMQQNIQELEEQLEEEE 956

Query: 231  TEISYLKGRIFPVEDQLEALKSES-----QNKIELLLQQHQDRIEQLISEHEVEITGLTE 285
            +    L+      E +L+ L+ E      QN     L + +  +E  I+E    +T   E
Sbjct: 957  SARQKLQLEKVTTEAKLKKLEEEQIILEDQN---CKLAKEKKLLEDRIAEFTTNLTEEEE 1013

Query: 286  KASSARSQANSIQSQMEIIQEQARNQNSMYM------RQL----SDLESTVSQLRSELRE 335
            K+ S     N  ++ +  ++E+ R +           R+L    +DL   +++L++++ E
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073

Query: 336  AKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL 395
             K     K EEL+  L    + + E   +++   ++   L+ Q+ +L  DL       + 
Sbjct: 1074 LKMQLAKKEEELQAAL----ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK 1129

Query: 396  EKEQNKRLWDR----DTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMA 451
             ++Q + L +      T    T+D    + + R+   Q +  L K L+ E +   E Q+ 
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTH-EAQIQ 1188

Query: 452  AIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERA 511
             ++ K+   + V  L  QLE TK +           K  LE +++T+ +    L  + + 
Sbjct: 1189 EMRQKHS--QAVEELAEQLEQTKRV-----------KANLEKAKQTLENERGELANEVKV 1235

Query: 512  IEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQI 571
            +     +    R +V+ +LQELQ   NEG+ +R    + +  KLQ+ E D V  +L Q  
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD-KVTKLQV-ELDNVTGLLSQSD 1293

Query: 572  ENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLE 631
               ++L          +Q  +  L++E   +     +LK ++D+K++   +LE    + E
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE----EEE 1349

Query: 632  LEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNK---SE 688
              K  L    +     V D+K++ +  +  ++T+      L ++ E L +    K    +
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD 1409

Query: 689  EMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAK------RGQ 742
            ++E T  +L+ +L     +L+  R +  ++E          +  +K I+AK      R +
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ-KKFDQLLAEEKTISAKYAEERDRAE 1468

Query: 743  IDA--LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
             +A   ++K   L  A+  A ++K  L+    +   E+  + + K+ +   +  L   +R
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLK 860
             L+++V  M+  L++   +    +D   R E     +K Q     ++LQG    S    K
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE---RDLQGRDEQSEEKKK 1585

Query: 861  PRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPA 920
              + Q   V    + +   +   S        A   ++    DLK L         E   
Sbjct: 1586 QLVRQ---VREMEAELEDERKQRSM-------AVAARKKLEMDLKDL---------EAHI 1626

Query: 921  VSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPV 980
             S +K  ++    L  L+ +++DC+ E     D        L  + E  K  +++  E +
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRE---LDDTRASREEILAQAKENEKKLKSMEAEMI 1683

Query: 981  TLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYR 1040
             L                AA+   K  A +      +      +  SS +G++    + R
Sbjct: 1684 QLQE------------ELAAAERAKRQAQQE-----RDELADEIANSSGKGALALEEKRR 1726

Query: 1041 SAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQL------KNQAMSSMI 1094
                I   +   + +    E      +K   +++ + T   DL L      KN+     +
Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT---DLNLERSHAQKNENARQQL 1783

Query: 1095 RNQEKRIQKVKDQE 1108
              Q K + KVK QE
Sbjct: 1784 ERQNKEL-KVKLQE 1796



 Score =  128 bits (322), Expect = 3e-29
 Identities = 193/990 (19%), Positives = 409/990 (41%), Gaps = 146/990 (14%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADI 132
            K+  E  + E++  + + + +     +L  K +      + DL+ +L             
Sbjct: 994  KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE----AMITDLEERL------------- 1036

Query: 133  RRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSI 192
            RR E Q QE     L+ T  +LE       D + +   QI +L+  +   E   +E+++ 
Sbjct: 1037 RREEKQRQE-----LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE---EELQAA 1088

Query: 193  LVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTE---ISYLKGRIFPVEDQLEA 249
            L   EE + +K     +M+    R L S IS++  +L++E    +  + +   + ++LEA
Sbjct: 1089 LARVEEEAAQK-----NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143

Query: 250  LKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQAR 309
            LK+E ++ ++    Q     ++L S+ E E+  L +   +   +A + ++Q+    ++ R
Sbjct: 1144 LKTELEDTLDSTAAQ-----QELRSKREQEVNILKK---TLEEEAKTHEAQI----QEMR 1191

Query: 310  NQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVL--------------AN 355
             ++S  + +L++      ++++ L +AK+  E++  EL  ++ +                
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251

Query: 356  SELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITID 415
            ++L E + + ++  +    L D++ KL  +L      LS    ++ +L    +     + 
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311

Query: 416  HLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKE 475
              +  L   N +   L   LK ++ E     E+     + K+   +++++L AQ+   K+
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKK 1371

Query: 476  MLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQH 535
             +   V  L   +      ++ +  L+   +EK  A +      T+L+  +D  L +L H
Sbjct: 1372 KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH 1431

Query: 536  LKNEGDHLRNVQ------------------------------TECEALKL---------Q 556
             +    +L   Q                               E +AL L         Q
Sbjct: 1432 QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ 1491

Query: 557  MTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELK-ILKDK 615
              E +++ +  R ++E++       G++   ++  K  LE+++ + + +L+EL+  L+  
Sbjct: 1492 KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 1551

Query: 616  KDAKI--------------RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
            +DAK+              R+L+ R    E +K +LV    E    ++D +++R   +  
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611

Query: 662  VKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGS 721
             K    +L +L    +   +N     +E      KL+ Q+K    EL+ TR        S
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKN----RDEAIKQLRKLQAQMKDCMRELDDTR-------AS 1660

Query: 722  DGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTV 781
                +  A   +K++ +   ++  LQ ++   E A   A +E+  L +E +  S + +  
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720

Query: 782  ATEKNKMAGELEVLRSQERRLKEKVTNMEV---ALDKASLQFAECQDII-----QRQEQE 833
              EK ++   +  L   E  L+E+  N E+    L KA+LQ  +    +       Q+ E
Sbjct: 1721 LEEKRRLEARIAQL---EEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777

Query: 834  SVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKA 893
            + R +L+     KEL+        ++K +    AS+T   + +   +     L + + + 
Sbjct: 1778 NARQQLER--QNKELKVKLQEMEGTVKSK--YKASITALEAKIAQLEEQ---LDNETKER 1830

Query: 894  NTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEED-GRTSLGALEDRVRDCITESSLRS 952
                +   R  K+L   L  V +E       K + D   T L  L+ ++ +   E+   +
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRAN 1890

Query: 953  DMCHRSNNSLRDSTEGSKSSETLSREPVTL 982
                +    L D+TE   +++ ++RE  +L
Sbjct: 1891 ASRRKLQRELEDATE---TADAMNREVSSL 1917



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 81/375 (21%), Positives = 168/375 (44%), Gaps = 34/375 (9%)

Query: 73   KEHFERVL----EEYSHQVKDLQRRLNESN---ELHEKQKFYLRQSVIDLQTKLQEMQME 125
            K  FER L    E+   + K L R++ E     E   KQ+     +   L+  L++++  
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625

Query: 126  RDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGV 185
             D+    R    +    L+ Q+++ + EL+  +  +E++L     Q ++  K + S E  
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL----AQAKENEKKLKSMEAE 1681

Query: 186  LQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVED 245
            + +++  L   E A  +   E D ++     S G     +      E   L+ RI  +E+
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL-----EEKRRLEARIAQLEE 1736

Query: 246  QLEALKSESQNKIELL---LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQME 302
            +LE    E Q   EL+   L++   +I+Q+ ++  +E +   +K  +AR Q      +++
Sbjct: 1737 ELE----EEQGNTELINDRLKKANLQIDQINTDLNLERSH-AQKNENARQQLERQNKELK 1791

Query: 303  I-IQEQARNQNSMYMRQLSDLESTVSQLRSEL------REAKRMYEDKTEELEKQLVLAN 355
            + +QE      S Y   ++ LE+ ++QL  +L      R+A      +TE+  K ++L  
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLL-- 1849

Query: 356  SELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITID 415
             ++ + R   +Q+  ++     +L++L   L + E+E        ++L       + T D
Sbjct: 1850 -QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETAD 1908

Query: 416  HLRRELDNRNMEVQR 430
             + RE+ +   +++R
Sbjct: 1909 AMNREVSSLKNKLRR 1923


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  136 bits (343), Expect = 1e-31
 Identities = 196/966 (20%), Positives = 387/966 (40%), Gaps = 128/966 (13%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L  K K  L Q V DL+  L++   E+    D+ R + + +
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTL-TKAKIKLEQQVDDLEGSLEQ---EKKLRMDLERAKRKLE 1062

Query: 141  EDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGV-------LQEIRSIL 193
             DL+   Q ++ ++E  K   ++ LK    +I  L+  +   + +       ++E+++ +
Sbjct: 1063 GDLK-LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121

Query: 194  VDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSE 253
             + EE       E +  S        S +S+ L E+   +    G          + + E
Sbjct: 1122 EELEEE-----IEAERASRAKAEKQRSDLSRELEEISERLEEAGG--------ATSAQIE 1168

Query: 254  SQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNS 313
               K E   Q+ +  +E+   +HE     L +K + + ++       ++ ++++   + S
Sbjct: 1169 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228

Query: 314  MYMRQLSDLES---TVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQ 370
                ++ DL S   TVS+ +  L +  R  ED+  EL+ +       + +   +R +   
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288

Query: 371  ESGNLDDQL---QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH----------- 416
            ESG    QL   + L++ L + ++  + + E+ KR  + +      + H           
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348

Query: 417  --------------LRRELDNRNMEV------------QRLEALLKALKSECQGQMERQM 450
                          L+R L   N EV            QR E L +A K   Q       
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ------- 1401

Query: 451  AAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKER 510
              +Q   E +E V++  A LE TK+ L+  VE+L      +   ERT +    +L +K+R
Sbjct: 1402 -RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL------MLDVERT-NAACAALDKKQR 1453

Query: 511  AIEATNAEITKLRSRVDLKLQELQ-HLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQ 569
              +   AE  +       +L+  Q   ++ G  L  ++   E    Q+    +  + L+Q
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513

Query: 570  QIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSD 629
            +I ++T+ + + G+    ++  K Q+E+E  + +  L+E +   + ++ KI  ++     
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ----- 1568

Query: 630  LELEKVKLVNAGSERLRAVKDIKQERDQL-LNEVKTSRSELNNLSEEYEV------LKRN 682
            LEL +VK     SE  R + +  +E DQL  N ++   S  + L  E         LK+ 
Sbjct: 1569 LELNQVK-----SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623

Query: 683  FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742
                  EME+  N        A      T+  LK  +     A++    +++Q+     +
Sbjct: 1624 MEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERR 1683

Query: 743  IDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATE-------KNKMAGELEVL 795
             + LQ++I+ L   +    + +   ++E    S+ +  + T+       K K+  ++  +
Sbjct: 1684 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQM 1743

Query: 796  RSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESV---RLKLQHTLDIKELQ--- 849
            + +   + ++  N E    KA    A   + +++++  S    R+K      +K+LQ   
Sbjct: 1744 QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1803

Query: 850  --GPGYTSNSSLKPRLLQPASVTRSHSNVPSSQ----STASFLSHHSTKANTLKEDPTRD 903
                        K      A V      V S Q         L  H  +   L      D
Sbjct: 1804 DEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEED 1863

Query: 904  LKQLLQELRSVINEEPAVSLS------KTEEDGRTSLGALEDRVRDCITESSLRSDMCHR 957
             K +L+ L+ ++++  A   S      + EE   T+L     +++  + E+  R+D+   
Sbjct: 1864 RKNILR-LQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR-KLQHELEEAEERADIAES 1921

Query: 958  SNNSLR 963
              N LR
Sbjct: 1922 QVNKLR 1927



 Score =  121 bits (303), Expect = 4e-27
 Identities = 206/1056 (19%), Positives = 429/1056 (40%), Gaps = 112/1056 (10%)

Query: 114  DLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIE 173
            ++ T  +E Q  +D +A    +  + +E +   L+   ++L+     + + L D+  + +
Sbjct: 854  EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-NDLQLQVQAEAEGLADAEERCD 912

Query: 174  QLRKMMLSHEGVLQEIRSILVDFEE------ASGKKICEHDSMSTLHFRSLGSAISKILR 227
            QL K  +  E  ++E+     D EE      A  +K+ +  S        L   ++K+ +
Sbjct: 913  QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972

Query: 228  E----------LDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLIS--- 274
            E          L  E++ L   I  +  + +AL+   Q  ++ L Q  +D++  L     
Sbjct: 973  EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL-QAEEDKVNTLTKAKI 1031

Query: 275  --EHEVE-ITGLTEKASSARSQAN----SIQSQMEIIQEQA---RNQNSMYMRQLSDLES 324
              E +V+ + G  E+    R         ++  +++ QE      N+      +L   E 
Sbjct: 1032 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 325  TVSQLRSELREAKRM---YEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQK 381
             +S L+S++ + + +    + K +EL+ ++     E+   R  R +  ++  +L  +L++
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151

Query: 382  LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSE 441
            +   L +     S + E NK+              +RR+L+   ++ +   A L+   ++
Sbjct: 1152 ISERLEEAGGATSAQIEMNKK-------REAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 442  CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDL 501
               ++  Q+  +Q   + LEK  S   +++   + L   VE ++  K  LE   RT+ D 
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 502  TTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL-----RNVQT---ECEAL 553
             + L+ KE   +    ++T  R R+  +  E     +E + L     R  Q    + E L
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321

Query: 554  KLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILK 613
            K Q+ E+ K    L   +++               Q  KA+L++ ++    E+ + +  K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT-K 1380

Query: 614  DKKDAKIRELEARVSDLELEKVKL---VNAGSERLRAVK----DIKQERDQLLNEVKTSR 666
             + DA       R  +LE  K KL   + A  E + AV      +++ + +L NEV+   
Sbjct: 1381 YETDAI-----QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435

Query: 667  SELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAM 726
             ++   +     L +  RN     +    + K + +   +ELE ++   +S+ G++   +
Sbjct: 1436 LDVERTNAACAALDKKQRN----FDKILAEWKQKCEETHAELEASQKEARSL-GTELFKI 1490

Query: 727  KVAMGMQ-KQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEK 785
            K A      Q+   + +   LQ +I  L E +    K  H L++ K ++ QE   +    
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 786  NKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRL--KLQHTL 843
             +    LE    +  R++ ++  ++  +D+   + AE  + I + ++  +R+   +Q TL
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHIRIVESMQSTL 1607

Query: 844  DIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTL--KEDPT 901
            D +                 L    +  +H+N  ++++  ++ +      +T    +D  
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667

Query: 902  RDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDC---ITESSLRSDMCHRS 958
            R  + L ++L  V  E  A  L    E+ R +L   E   +     + ++S R  + H  
Sbjct: 1668 RSQEDLKEQLAMV--ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725

Query: 959  NNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKK 1018
            N SL ++    K  ET     ++   G+ ED                   +R+     KK
Sbjct: 1726 NTSLINT---KKKLET----DISQMQGEMEDIL---------------QEARNAEEKAKK 1763

Query: 1019 SPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQ-------SPPIETTGKTCRKLQN 1071
            +   + + +        TS +      +   +VKD Q          ++   K  +KL+ 
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823

Query: 1072 RLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
            R+  L+  VE  Q +N      +R  E+R++++  Q
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQ 1859



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 126/624 (20%), Positives = 261/624 (41%), Gaps = 88/624 (14%)

Query: 390  EKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQ 449
            EKE++  KE+ +++ D    +    +  R+EL+      +++  LLK  K++ Q Q++ +
Sbjct: 852  EKEMATMKEEFQKIKDELAKS----EAKRKELE------EKMVTLLKE-KNDLQLQVQAE 900

Query: 450  MAAIQGKNESLEKVSSLTAQLES-TKEMLRKVVE------ELTAKKMTLESS----ERTI 498
               +    E  +++     QLE+  KE+  +  +      ELTAKK  LE      ++ I
Sbjct: 901  AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960

Query: 499  SDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMT 558
             DL  +L + E+   AT  ++  L   +    + +  L  E   L+  +   + L     
Sbjct: 961  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ--EAHQQTLDDLQA 1018

Query: 559  EKDKVIEI------LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKIL 612
            E+DKV  +      L QQ++++   + Q  +    ++  K +LE ++   +  + +++  
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078

Query: 613  KDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRS----- 667
            K + D K+++ E  +S+L+ +       G +  + +K+++   ++L  E++  R+     
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 668  --ELNNLSEEYEVLKRNFR------------NKSEEMEMTTNKLKMQLKSAQSELEQTRN 713
              + ++LS E E +                 NK  E E    K++  L+ A  + E T  
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF--QKMRRDLEEATLQHEATAA 1196

Query: 714  TLKSMEGSD--------GHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKH 765
            TL+               +  +V   ++K+ +  + +ID L S ++ + +A  N  K   
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256

Query: 766  FLKEEKSKL---SQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAE 822
             L+++ S+L    +E   +  +     G L+    +  R  ++   +   L +    F +
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316

Query: 823  CQDIIQRQEQESVRLK--LQHTLDIK----ELQGPGYTSNSSLKPRLLQPASVTRSHSNV 876
              + ++RQ +E ++ K  L H L       +L    Y      K  L +  S        
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALS-------- 1368

Query: 877  PSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAV-----SLSKTEEDGR 931
             ++   A + + + T A    E+     K+L Q L++      AV     SL KT++   
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ--- 1425

Query: 932  TSLGALEDRVRDCITESSLRSDMC 955
                 L++ V D + +    +  C
Sbjct: 1426 ----RLQNEVEDLMLDVERTNAAC 1445



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 77/378 (20%), Positives = 161/378 (42%), Gaps = 31/378 (8%)

Query: 590  VEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVK 649
            ++ A+ EKE+   + E +++K    K +AK +ELE ++  L  EK  L          + 
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905

Query: 650  DIKQERDQL----------LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKM 699
            D ++  DQL          + EV     +   ++ E    KR   ++  E++   + L++
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965

Query: 700  QLKSAQSELEQTRNTLKS----MEGSDGHAMKVAMGMQKQITAKRGQIDALQS---KIQF 752
             L   + E   T N +K+    M G D    K+    +    A +  +D LQ+   K+  
Sbjct: 966  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 753  LEEAMTNANKEKHFLK---EEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNM 809
            L +A     ++   L+   E++ KL  +L      K K+ G+L++ +     ++ +   +
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA---KRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 810  EVALDKASLQFAECQDIIQRQEQESVRLKLQHTLD-----IKELQGPGYTSNSSLKPRLL 864
            +  L K   + +  Q  I  ++++++ ++LQ  +      I+EL+       +S      
Sbjct: 1083 DEKLKKKEFEISNLQSKI--EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEK 1140

Query: 865  QPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLS 924
            Q + ++R    +      A   +    + N  +E   + +++ L+E  ++ +E  A +L 
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE-ATLQHEATAATLR 1199

Query: 925  KTEEDGRTSLGALEDRVR 942
            K   D    LG   D ++
Sbjct: 1200 KKHADSVAELGEQIDNLQ 1217



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 20/127 (15%)

Query: 75   HFERVLEEYSHQVKDLQRRLNESNEL----HEKQKFYLRQSVIDLQTKLQ-EMQMERDAM 129
            H ER+ +     VKDLQ RL+E+ +L     +KQ   L   V +L+ +++ E +   +A+
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843

Query: 130  ADIRRRES-------QSQEDLRN--QLQNTVHELEAA----KCLKEDMLKDSNTQIEQLR 176
              +R+ E        Q++ED +N  +LQ+ V +L+A     K   E+  + SNT + + R
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR 1903

Query: 177  KMMLSHE 183
            K  L HE
Sbjct: 1904 K--LQHE 1908


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  136 bits (343), Expect = 1e-31
 Identities = 196/966 (20%), Positives = 387/966 (40%), Gaps = 128/966 (13%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L  K K  L Q V DL+  L++   E+    D+ R + + +
Sbjct: 1007 EAHQQTLDDLQAEEDKVNTL-TKAKIKLEQQVDDLEGSLEQ---EKKLRMDLERAKRKLE 1062

Query: 141  EDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGV-------LQEIRSIL 193
             DL+   Q ++ ++E  K   ++ LK    +I  L+  +   + +       ++E+++ +
Sbjct: 1063 GDLK-LAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121

Query: 194  VDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSE 253
             + EE       E +  S        S +S+ L E+   +    G          + + E
Sbjct: 1122 EELEEE-----IEAERASRAKAEKQRSDLSRELEEISERLEEAGG--------ATSAQIE 1168

Query: 254  SQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNS 313
               K E   Q+ +  +E+   +HE     L +K + + ++       ++ ++++   + S
Sbjct: 1169 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1228

Query: 314  MYMRQLSDLES---TVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQ 370
                ++ DL S   TVS+ +  L +  R  ED+  EL+ +       + +   +R +   
Sbjct: 1229 EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT 1288

Query: 371  ESGNLDDQL---QKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH----------- 416
            ESG    QL   + L++ L + ++  + + E+ KR  + +      + H           
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348

Query: 417  --------------LRRELDNRNMEV------------QRLEALLKALKSECQGQMERQM 450
                          L+R L   N EV            QR E L +A K   Q       
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ------- 1401

Query: 451  AAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKER 510
              +Q   E +E V++  A LE TK+ L+  VE+L      +   ERT +    +L +K+R
Sbjct: 1402 -RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL------MLDVERT-NAACAALDKKQR 1453

Query: 511  AIEATNAEITKLRSRVDLKLQELQ-HLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQ 569
              +   AE  +       +L+  Q   ++ G  L  ++   E    Q+    +  + L+Q
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513

Query: 570  QIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSD 629
            +I ++T+ + + G+    ++  K Q+E+E  + +  L+E +   + ++ KI  ++     
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ----- 1568

Query: 630  LELEKVKLVNAGSERLRAVKDIKQERDQL-LNEVKTSRSELNNLSEEYEV------LKRN 682
            LEL +VK     SE  R + +  +E DQL  N ++   S  + L  E         LK+ 
Sbjct: 1569 LELNQVK-----SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623

Query: 683  FRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742
                  EME+  N        A      T+  LK  +     A++    +++Q+     +
Sbjct: 1624 MEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERR 1683

Query: 743  IDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATE-------KNKMAGELEVL 795
             + LQ++I+ L   +    + +   ++E    S+ +  + T+       K K+  ++  +
Sbjct: 1684 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQM 1743

Query: 796  RSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESV---RLKLQHTLDIKELQ--- 849
            + +   + ++  N E    KA    A   + +++++  S    R+K      +K+LQ   
Sbjct: 1744 QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRL 1803

Query: 850  --GPGYTSNSSLKPRLLQPASVTRSHSNVPSSQ----STASFLSHHSTKANTLKEDPTRD 903
                        K      A V      V S Q         L  H  +   L      D
Sbjct: 1804 DEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEED 1863

Query: 904  LKQLLQELRSVINEEPAVSLS------KTEEDGRTSLGALEDRVRDCITESSLRSDMCHR 957
             K +L+ L+ ++++  A   S      + EE   T+L     +++  + E+  R+D+   
Sbjct: 1864 RKNILR-LQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR-KLQHELEEAEERADIAES 1921

Query: 958  SNNSLR 963
              N LR
Sbjct: 1922 QVNKLR 1927



 Score =  121 bits (303), Expect = 4e-27
 Identities = 206/1056 (19%), Positives = 429/1056 (40%), Gaps = 112/1056 (10%)

Query: 114  DLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIE 173
            ++ T  +E Q  +D +A    +  + +E +   L+   ++L+     + + L D+  + +
Sbjct: 854  EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-NDLQLQVQAEAEGLADAEERCD 912

Query: 174  QLRKMMLSHEGVLQEIRSILVDFEE------ASGKKICEHDSMSTLHFRSLGSAISKILR 227
            QL K  +  E  ++E+     D EE      A  +K+ +  S        L   ++K+ +
Sbjct: 913  QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972

Query: 228  E----------LDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLIS--- 274
            E          L  E++ L   I  +  + +AL+   Q  ++ L Q  +D++  L     
Sbjct: 973  EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL-QAEEDKVNTLTKAKI 1031

Query: 275  --EHEVE-ITGLTEKASSARSQAN----SIQSQMEIIQEQA---RNQNSMYMRQLSDLES 324
              E +V+ + G  E+    R         ++  +++ QE      N+      +L   E 
Sbjct: 1032 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091

Query: 325  TVSQLRSELREAKRM---YEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQK 381
             +S L+S++ + + +    + K +EL+ ++     E+   R  R +  ++  +L  +L++
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151

Query: 382  LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSE 441
            +   L +     S + E NK+              +RR+L+   ++ +   A L+   ++
Sbjct: 1152 ISERLEEAGGATSAQIEMNKK-------REAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 442  CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDL 501
               ++  Q+  +Q   + LEK  S   +++   + L   VE ++  K  LE   RT+ D 
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 502  TTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL-----RNVQT---ECEAL 553
             + L+ KE   +    ++T  R R+  +  E     +E + L     R  Q    + E L
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321

Query: 554  KLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILK 613
            K Q+ E+ K    L   +++               Q  KA+L++ ++    E+ + +  K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT-K 1380

Query: 614  DKKDAKIRELEARVSDLELEKVKL---VNAGSERLRAVK----DIKQERDQLLNEVKTSR 666
             + DA       R  +LE  K KL   + A  E + AV      +++ + +L NEV+   
Sbjct: 1381 YETDAI-----QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435

Query: 667  SELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAM 726
             ++   +     L +  RN     +    + K + +   +ELE ++   +S+ G++   +
Sbjct: 1436 LDVERTNAACAALDKKQRN----FDKILAEWKQKCEETHAELEASQKEARSL-GTELFKI 1490

Query: 727  KVAMGMQ-KQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEK 785
            K A      Q+   + +   LQ +I  L E +    K  H L++ K ++ QE   +    
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 786  NKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRL--KLQHTL 843
             +    LE    +  R++ ++  ++  +D+   + AE  + I + ++  +R+   +Q TL
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHIRIVESMQSTL 1607

Query: 844  DIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTL--KEDPT 901
            D +                 L    +  +H+N  ++++  ++ +      +T    +D  
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667

Query: 902  RDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDC---ITESSLRSDMCHRS 958
            R  + L ++L  V  E  A  L    E+ R +L   E   +     + ++S R  + H  
Sbjct: 1668 RSQEDLKEQLAMV--ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725

Query: 959  NNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKK 1018
            N SL ++    K  ET     ++   G+ ED                   +R+     KK
Sbjct: 1726 NTSLINT---KKKLET----DISQMQGEMEDIL---------------QEARNAEEKAKK 1763

Query: 1019 SPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQ-------SPPIETTGKTCRKLQN 1071
            +   + + +        TS +      +   +VKD Q          ++   K  +KL+ 
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823

Query: 1072 RLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
            R+  L+  VE  Q +N      +R  E+R++++  Q
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQ 1859



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 126/624 (20%), Positives = 261/624 (41%), Gaps = 88/624 (14%)

Query: 390  EKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQ 449
            EKE++  KE+ +++ D    +    +  R+EL+      +++  LLK  K++ Q Q++ +
Sbjct: 852  EKEMATMKEEFQKIKDELAKS----EAKRKELE------EKMVTLLKE-KNDLQLQVQAE 900

Query: 450  MAAIQGKNESLEKVSSLTAQLES-TKEMLRKVVE------ELTAKKMTLESS----ERTI 498
               +    E  +++     QLE+  KE+  +  +      ELTAKK  LE      ++ I
Sbjct: 901  AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960

Query: 499  SDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMT 558
             DL  +L + E+   AT  ++  L   +    + +  L  E   L+  +   + L     
Sbjct: 961  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ--EAHQQTLDDLQA 1018

Query: 559  EKDKVIEI------LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKIL 612
            E+DKV  +      L QQ++++   + Q  +    ++  K +LE ++   +  + +++  
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENE 1078

Query: 613  KDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRS----- 667
            K + D K+++ E  +S+L+ +       G +  + +K+++   ++L  E++  R+     
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138

Query: 668  --ELNNLSEEYEVLKRNFR------------NKSEEMEMTTNKLKMQLKSAQSELEQTRN 713
              + ++LS E E +                 NK  E E    K++  L+ A  + E T  
Sbjct: 1139 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF--QKMRRDLEEATLQHEATAA 1196

Query: 714  TLKSMEGSD--------GHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKH 765
            TL+               +  +V   ++K+ +  + +ID L S ++ + +A  N  K   
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256

Query: 766  FLKEEKSKL---SQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAE 822
             L+++ S+L    +E   +  +     G L+    +  R  ++   +   L +    F +
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316

Query: 823  CQDIIQRQEQESVRLK--LQHTLDIK----ELQGPGYTSNSSLKPRLLQPASVTRSHSNV 876
              + ++RQ +E ++ K  L H L       +L    Y      K  L +  S        
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALS-------- 1368

Query: 877  PSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAV-----SLSKTEEDGR 931
             ++   A + + + T A    E+     K+L Q L++      AV     SL KT++   
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQ--- 1425

Query: 932  TSLGALEDRVRDCITESSLRSDMC 955
                 L++ V D + +    +  C
Sbjct: 1426 ----RLQNEVEDLMLDVERTNAAC 1445



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 77/378 (20%), Positives = 161/378 (42%), Gaps = 31/378 (8%)

Query: 590  VEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVK 649
            ++ A+ EKE+   + E +++K    K +AK +ELE ++  L  EK  L          + 
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905

Query: 650  DIKQERDQL----------LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKM 699
            D ++  DQL          + EV     +   ++ E    KR   ++  E++   + L++
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965

Query: 700  QLKSAQSELEQTRNTLKS----MEGSDGHAMKVAMGMQKQITAKRGQIDALQS---KIQF 752
             L   + E   T N +K+    M G D    K+    +    A +  +D LQ+   K+  
Sbjct: 966  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025

Query: 753  LEEAMTNANKEKHFLK---EEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNM 809
            L +A     ++   L+   E++ KL  +L      K K+ G+L++ +     ++ +   +
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERA---KRKLEGDLKLAQESIMDIENEKQQL 1082

Query: 810  EVALDKASLQFAECQDIIQRQEQESVRLKLQHTLD-----IKELQGPGYTSNSSLKPRLL 864
            +  L K   + +  Q  I  ++++++ ++LQ  +      I+EL+       +S      
Sbjct: 1083 DEKLKKKEFEISNLQSKI--EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEK 1140

Query: 865  QPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLS 924
            Q + ++R    +      A   +    + N  +E   + +++ L+E  ++ +E  A +L 
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE-ATLQHEATAATLR 1199

Query: 925  KTEEDGRTSLGALEDRVR 942
            K   D    LG   D ++
Sbjct: 1200 KKHADSVAELGEQIDNLQ 1217



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 40/127 (31%), Positives = 67/127 (52%), Gaps = 20/127 (15%)

Query: 75   HFERVLEEYSHQVKDLQRRLNESNEL----HEKQKFYLRQSVIDLQTKLQ-EMQMERDAM 129
            H ER+ +     VKDLQ RL+E+ +L     +KQ   L   V +L+ +++ E +   +A+
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843

Query: 130  ADIRRRES-------QSQEDLRN--QLQNTVHELEAA----KCLKEDMLKDSNTQIEQLR 176
              +R+ E        Q++ED +N  +LQ+ V +L+A     K   E+  + SNT + + R
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR 1903

Query: 177  KMMLSHE 183
            K  L HE
Sbjct: 1904 K--LQHE 1908


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  136 bits (342), Expect = 1e-31
 Identities = 200/975 (20%), Positives = 399/975 (40%), Gaps = 146/975 (14%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L  K K  L Q V DL+  L++   E+    D+ R + + +
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTL-TKAKIKLEQQVDDLEGSLEQ---EKKIRMDLERAKRKLE 1060

Query: 141  EDLR------NQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILV 194
             DL+        ++N   +L+     KE  +    ++IE  + + +  +  ++E+++ + 
Sbjct: 1061 GDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIE 1120

Query: 195  DFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSES 254
            + EE       E +  S        S +S+ L E+   +    G          + + E 
Sbjct: 1121 ELEEE-----IEAERASRAKAEKQRSDLSRELEEISERLEEAGG--------ATSAQIEM 1167

Query: 255  QNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSM 314
              K E   Q+ +  +E+   +HE     L +K + + ++       ++ ++++   + S 
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1227

Query: 315  YMRQLSDLES---TVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQE 371
               ++ DL S   TVS+ +  L +  R  ED+  E++ +       + +   +R +   E
Sbjct: 1228 MKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTE 1287

Query: 372  SGNLDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH------------ 416
            SG    QL +   L++ L + ++  + + E+ KR  + +      + H            
Sbjct: 1288 SGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLL 1347

Query: 417  -------------LRRELDNRNMEV------------QRLEALLKALKSECQGQMERQMA 451
                         L+R +   N EV            QR E L +A K   Q        
Sbjct: 1348 REQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ-------- 1399

Query: 452  AIQGKNESLEKVSSLTAQLESTKEMLRKVVEEL-------TAKKMTLESSERTISDLTTS 504
             +Q   E +E V++  A LE TK+ L+  VE+L        A    L+  +R    +   
Sbjct: 1400 RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI--- 1456

Query: 505  LQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVI 564
            L E ++  E T+AE+   +        EL  +KN  +   +   + E LK +        
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD---QLETLKRENKN----- 1508

Query: 565  EILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELE 624
              L+Q+I ++T+ + + G+    ++  K Q+E+E ++ +  L+E +   + ++ KI  ++
Sbjct: 1509 --LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566

Query: 625  ARVSDLELEKVKLVNAGSERLRAVKDIKQERDQL-LNEVKTSRSELNNLSEEYEVLKRNF 683
                 LEL +VK     SE  R + +  +E DQ+  N ++   S  + L  E        
Sbjct: 1567 -----LELNQVK-----SEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI 1616

Query: 684  RNKSEEMEMTTNKLKMQL----KSAQSELEQTRNTLKSMEGSDGH---AMKVAMGMQKQI 736
            R K ++ME   N++++QL    + A   L   RNT   ++ +  H   A++    +++Q+
Sbjct: 1617 RLK-KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQL 1675

Query: 737  TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATE-------KNKMA 789
                 + + LQ++I+ L   +    + +   ++E    S+ +  + T+       K K+ 
Sbjct: 1676 AMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1735

Query: 790  GELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLK----------- 838
             ++  ++ +   + ++  N E    KA    A   + +++++  S  L+           
Sbjct: 1736 TDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795

Query: 839  -LQHTLDIKE---LQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKAN 894
             LQH LD  E   L+G G      L+ R+ +      S      +      L  H  K  
Sbjct: 1796 DLQHRLDEAEQLALKG-GKKQIQKLEARVRELEGEVESEQK--RNVEAVKGLRKHERKVK 1852

Query: 895  TLKEDPTRDLKQLLQELRSVINEEPAVSLS------KTEEDGRTSLGALEDRVRDCITES 948
             L      D K +L+ L+ ++++  A   S      + EE    +L     R++  + E+
Sbjct: 1853 ELTYQTEEDRKNILR-LQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFR-RIQHELEEA 1910

Query: 949  SLRSDMCHRSNNSLR 963
              R+D+     N LR
Sbjct: 1911 EERADIAESQVNKLR 1925



 Score =  106 bits (265), Expect = 1e-22
 Identities = 129/682 (18%), Positives = 283/682 (41%), Gaps = 89/682 (13%)

Query: 56   KYEVELDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDL 115
            +Y  +LD    ++         R  + ++ Q+++L+R+L E  +        L+ S  D 
Sbjct: 1290 EYSRQLDEKDTLV-----SQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDC 1344

Query: 116  QTKLQEMQMERDAMADIRRRESQSQEDLR--------NQLQNTVHELEAAKCLKEDMLKD 167
                ++ + E++A A+++R  S++  ++         + +Q T  ELE AK      L+D
Sbjct: 1345 DLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQD 1403

Query: 168  SNTQIEQLRKMMLSHEGVLQ----EIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAIS 223
            +   +E +     S E   Q    E+  +++D E  +    C              +A+ 
Sbjct: 1404 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAA--C--------------AALD 1447

Query: 224  KILRELDTEISYLKGRIFPVEDQLEALKSESQN------KIELLLQQHQDRIEQLISEH- 276
            K  R  D  ++  K +      +LEA + ES++      KI+   ++  D++E L  E+ 
Sbjct: 1448 KKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENK 1507

Query: 277  --EVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELR 334
              + EI+ LTE+ +    + +    ++E I++Q   + S     L + E+++     ++ 
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQEKSELQAALEEAEASLEHEEGKIL 1563

Query: 335  EAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLL-ADLHKREKEL 393
              +        E+++++   + E+       DQ  +    + + +Q  L A++  R   +
Sbjct: 1564 RIQLELNQVKSEVDRKIAEKDEEI-------DQMKRNHIRIVESMQSTLDAEIRSRNDAI 1616

Query: 394  SLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAI 453
             L+K+    L + +    I ++H  R         +  +A+LK  +      +  Q    
Sbjct: 1617 RLKKKMEGDLNEME----IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQ---- 1668

Query: 454  QGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIE 513
                   E +    A +E    +L+  +EEL A     E S +          E+ + + 
Sbjct: 1669 -------EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1721

Query: 514  ATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIEN 573
              N  +   + +++  + ++Q      D ++  +   E  K  +T+   + E L+++ + 
Sbjct: 1722 TQNTSLINTKKKLETDISQIQGEME--DIIQEARNAEEKAKKAITDAAMMAEELKKEQDT 1779

Query: 574  MTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKK-----DAKIRELEARVS 628
               L          M+    Q  K++  R  E ++L +   KK     +A++RELE  V 
Sbjct: 1780 SAHLE--------RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVE 1831

Query: 629  DLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSE 688
              +   V+ V    +  R VK++  + +    E + +   L +L ++ +   ++++ ++E
Sbjct: 1832 SEQKRNVEAVKGLRKHERKVKELTYQTE----EDRKNILRLQDLVDKLQAKVKSYKRQAE 1887

Query: 689  EMEMTTNKLKMQLKSAQSELEQ 710
            E E  +N    + +  Q ELE+
Sbjct: 1888 EAEEQSNVNLSKFRRIQHELEE 1909



 Score =  104 bits (260), Expect = 4e-22
 Identities = 167/825 (20%), Positives = 343/825 (41%), Gaps = 135/825 (16%)

Query: 228  ELDTEISYLKGRIFPVEDQL---EALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLT 284
            E + E++ +K      +++L   EA + E + K+  L+Q+  D   Q+ +E +  +    
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD-SLADAE 906

Query: 285  EKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKT 344
            E+          ++++++ + E+A ++                ++ +EL   KR  ED+ 
Sbjct: 907  ERCDQLIKTKIQLEAKIKEVTERAEDEE---------------EINAELTAKKRKLEDEC 951

Query: 345  EELEKQLVLANSELTEARTERDQFSQESG--NLDDQLQKLLADLHKREKELSLEKEQNKR 402
             EL+K +   + ELT A+ E+++ + E+   NL +++  L   + K  KE    +E +++
Sbjct: 952  SELKKDI--DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009

Query: 403  LWD-----RDTGNSIT---------IDHLRRELDNRN---MEVQR----LEALLKAL--- 438
              D      D  N++T         +D L   L+      M+++R    LE  LK     
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069

Query: 439  -------KSECQGQMERQMAAIQGKNESLEKVSSLTAQLEST-KEM---LRKVVEELTAK 487
                   K +   +++++   + G    +E   +L  QL+   KE+   + ++ EE+ A+
Sbjct: 1070 TMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAE 1129

Query: 488  KMTLESSERTISDLTTSLQEKERAIE----ATNAEITKLRSRVDLKLQELQHLKNEGDHL 543
            + +   +E+  SDL+  L+E    +E    AT+A+I   + R + + Q+++    E    
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR-EAEFQKMRRDLEEA--- 1185

Query: 544  RNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRR 603
              +Q E  A  L+    D V E L +QI+N+ ++              K +LEKE ++ +
Sbjct: 1186 -TLQHEATAATLRKKHADSVAE-LGEQIDNLQRV--------------KQKLEKEKSEMK 1229

Query: 604  MELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVK 663
            ME+ +L        + +  +     +LE    K+  A  ++L  +K  ++E+ +L+N++ 
Sbjct: 1230 MEIDDLA-------SNMETVSKAKGNLE----KMCRALEDQLSEIKTKEEEQQRLINDLT 1278

Query: 664  TSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDG 723
              R+ L   S EY         + +E +   ++L    ++   ++E+ +  L+    +  
Sbjct: 1279 AQRARLQTESGEYS-------RQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKS 1331

Query: 724  HAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKE---------------KHFLK 768
                     +      R Q +  Q     L+ AM+ AN E                  L+
Sbjct: 1332 ALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELE 1391

Query: 769  EEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEV----------ALDKASL 818
            E K KL+Q L         +  +   L   ++RL+ +V ++ +          ALDK   
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451

Query: 819  QFAE-CQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVP 877
             F +   +  Q+ E+    L+     + + L    +   ++ +  L Q  ++ R + N+ 
Sbjct: 1452 NFDKILAEWKQKCEETHAELEASQK-ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ 1510

Query: 878  SSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGR-----T 932
               S  +       K     E   + ++Q   EL++ + E  A   S   E+G+      
Sbjct: 1511 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEA---SLEHEEGKILRIQL 1567

Query: 933  SLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSR 977
             L  ++  V   I E     D   R++  + +S + +  +E  SR
Sbjct: 1568 ELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSR 1612



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 76/378 (20%), Positives = 161/378 (42%), Gaps = 31/378 (8%)

Query: 590  VEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVK 649
            ++ A+ EKE+ + + E ++ K    K +AK +ELE ++  L  EK  L         ++ 
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903

Query: 650  DIKQERDQL----------LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKM 699
            D ++  DQL          + EV     +   ++ E    KR   ++  E++   + L++
Sbjct: 904  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963

Query: 700  QLKSAQSELEQTRNTLKS----MEGSDGHAMKVAMGMQKQITAKRGQIDALQS---KIQF 752
             L   + E   T N +K+    M G D    K+    +    A +  +D LQ+   K+  
Sbjct: 964  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023

Query: 753  LEEAMTNANKEKHFLK---EEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNM 809
            L +A     ++   L+   E++ K+  +L      K K+ G+L++ +     ++     +
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERA---KRKLEGDLKLAQESTMDIENDKQQL 1080

Query: 810  EVALDKASLQFAECQDIIQRQEQESVRLKLQHTLD-----IKELQGPGYTSNSSLKPRLL 864
            +  L K   + +  Q  I  ++++++ ++LQ  +      I+EL+       +S      
Sbjct: 1081 DEKLKKKEFEMSGLQSKI--EDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEK 1138

Query: 865  QPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLS 924
            Q + ++R    +      A   +    + N  +E   + +++ L+E  ++ +E  A +L 
Sbjct: 1139 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE-ATLQHEATAATLR 1197

Query: 925  KTEEDGRTSLGALEDRVR 942
            K   D    LG   D ++
Sbjct: 1198 KKHADSVAELGEQIDNLQ 1215



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 102/526 (19%), Positives = 206/526 (39%), Gaps = 67/526 (12%)

Query: 609  LKILKDKKDAKIRELEARVSDL------ELEKVKLVNAGSE------RLRAVKDIKQ--- 653
            L +L++ +D K+ +L  R   +       +E  K+V            +RA  ++K    
Sbjct: 774  LGLLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPW 833

Query: 654  -----ERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSEL 708
                 +   LL   +T + E+ N+ EE+E  K       EE+  T  K K +L+     L
Sbjct: 834  MKLYFKIKPLLKSAETEK-EMANMKEEFEKTK-------EELAKTEAKRK-ELEEKMVTL 884

Query: 709  EQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLK 768
             Q +N L+    ++  ++  A     Q+   + Q++A   KI+ + E   +  +    L 
Sbjct: 885  MQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEA---KIKEVTERAEDEEEINAELT 941

Query: 769  EEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQ 828
             +K KL  E S +  + + +   L  +  ++   + KV N+       + + A   + I 
Sbjct: 942  AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL-------TEEMAGLDETIA 994

Query: 829  RQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSH 888
            +  +E   L+  H   + +LQ      N+  K ++     V     ++   +     L  
Sbjct: 995  KLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLER 1054

Query: 889  HSTKAN---TLKEDPTRDLKQLLQELRSVINE---EPAVSLSKTEEDGRTSLGALEDRVR 942
               K      L ++ T D++   Q+L   + +   E +   SK E++      AL  +++
Sbjct: 1055 AKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ-----ALGMQLQ 1109

Query: 943  DCITESSLRSDMCHRSNNSLRDS-TEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAAS 1001
              I E   R +       + R S  +  K    LSRE   +   +R + +G      A S
Sbjct: 1110 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI--SERLEEAG-----GATS 1162

Query: 1002 PSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIET 1061
              ++ +  R       +  +        E ++   +   + +  H+ DSV +     I+ 
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLE-------EATLQHEATAATLRKKHA-DSVAEL-GEQIDN 1213

Query: 1062 TGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
              +  +KL+     ++  ++DL    + +S    N EK  + ++DQ
Sbjct: 1214 LQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQ 1259


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  136 bits (342), Expect = 1e-31
 Identities = 209/982 (21%), Positives = 397/982 (40%), Gaps = 160/982 (16%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L  K K  L Q V DL+  L++   E+    D+ R + + +
Sbjct: 1005 EAHQQTLDDLQMEEDKVNTL-TKAKTKLEQQVDDLEGSLEQ---EKKLCMDLERAKRKLE 1060

Query: 141  EDLRNQLQNTVHELEAAKCLKEDMLKD----SNTQ--IEQLRKMMLSHEGVLQEIRSILV 194
             DL+   ++T+      + L E + K     SN Q  IE  + + +  +  ++E+++ + 
Sbjct: 1061 GDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIE 1120

Query: 195  DFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSES 254
            + EE       E +  S        S +S+ L E+   +    G          + + E 
Sbjct: 1121 ELEEE-----IEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT--------SAQIEM 1167

Query: 255  QNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSM 314
              K E   Q+ +  +E+   +HE     L +K + + ++       ++ ++++   + S 
Sbjct: 1168 NKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSE 1227

Query: 315  YMRQLSDLES---TVSQLRSELREAKRMYED-----KTEELEKQLVLANSELTEAR--TE 364
               +++DL S   TVS+ ++   +  R  ED     KT+E E+Q ++      +AR  TE
Sbjct: 1228 LKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTE 1287

Query: 365  RDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH-------- 416
              +FS++     D+   +++ L + ++  + + E+ KR  + +T    T+ H        
Sbjct: 1288 SGEFSRQL----DEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHD 1343

Query: 417  -----------------LRRELDNRNMEV------------QRLEALLKALKSECQGQME 447
                             L+R +   N EV            QR E L +A K   Q    
Sbjct: 1344 CDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ---- 1399

Query: 448  RQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEEL-------TAKKMTLESSERTISD 500
                 +Q   E +E V+S  A LE TK+ L+  VE+L        A  + L+  +R    
Sbjct: 1400 ----RLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDK 1455

Query: 501  LTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG----DHLRNVQTECEALKLQ 556
            +   L E ++  E T AE+   +        EL  +KN      DHL  ++ E + L+  
Sbjct: 1456 V---LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQ-- 1510

Query: 557  MTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKK 616
                        Q+I ++T+ + + G+    ++  K QL+ E ++ +  L+E +   + +
Sbjct: 1511 ------------QEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHE 1558

Query: 617  DAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLL-NEVKTSRSELNNLSEE 675
            + KI  ++     LEL +VK     SE  R + +  +E DQL  N ++   S  + L  E
Sbjct: 1559 EGKILRIQ-----LELNQVK-----SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAE 1608

Query: 676  YEV------LKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLK--------SMEGS 721
                     +K+       EME+  N    Q   A   L  T+  LK        ++ G 
Sbjct: 1609 IRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQ 1668

Query: 722  DGHAMKVAMG------MQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLS 775
            D    ++AM       MQ ++   R  ++  +   +  E+ + +A++    L  + + L 
Sbjct: 1669 DDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLI 1728

Query: 776  QELSTVATEKNKMAGELEVL----RSQERRLKEKVTN---MEVALDKASLQFAECQDIIQ 828
                 + T+ +++ GE+E +    R+ E + K+ +T+   M   L K     A  + + +
Sbjct: 1729 NTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788

Query: 829  RQEQ--ESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFL 886
              EQ  + ++L+L     +    G         + R L+    +    NV + +     L
Sbjct: 1789 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKG----L 1844

Query: 887  SHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSK-----TEEDGRTSLGALEDRV 941
              H  +   L      D K +L+    V   +  V   K      EE    +L     ++
Sbjct: 1845 RKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFR-KL 1903

Query: 942  RDCITESSLRSDMCHRSNNSLR 963
            +  + E+  R+D+     N LR
Sbjct: 1904 QHELEEAKERADIAESQVNKLR 1925



 Score =  118 bits (295), Expect = 4e-26
 Identities = 205/1066 (19%), Positives = 422/1066 (39%), Gaps = 144/1066 (13%)

Query: 120  QEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMM 179
            +E +  ++ +A    +  + +E +   +Q   ++L+     + D L D+  + +QL K  
Sbjct: 858  EEFEKTKEELAKTEAKRKELEEKMVTLMQEK-NDLQLQVQAEADALADAEERCDQLIKTK 916

Query: 180  LSHEGVLQEIRSILVDFEE------ASGKKICEHDSMSTLHFRSLGSAISKILRE----- 228
            +  E  ++E+     D EE      A  +K+ +  S        L   ++K+ +E     
Sbjct: 917  IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 976

Query: 229  -----LDTEISYLKGRIFPVEDQLEALKSESQNKIELL---------LQQHQDRIEQLIS 274
                 L  E++ L   I  +  + +AL+   Q  ++ L         L + + ++EQ + 
Sbjct: 977  NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036

Query: 275  EHEVEITGLTEKASSARSQANSIQSQMEIIQEQA---RNQNSMYMRQLSDLESTVSQLRS 331
            + E  +    +           ++  +++ QE      N       +L   E  +S L+ 
Sbjct: 1037 DLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQG 1096

Query: 332  ELREAKRM---YEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHK 388
            ++ + + +    + K +EL+ ++     E+   R  R +  ++  +L  +L+++   L +
Sbjct: 1097 KIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156

Query: 389  REKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMER 448
                 S + E NK+              +RR+L+   ++ +   A L+   ++   ++  
Sbjct: 1157 AGGATSAQIEMNKK-------REAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209

Query: 449  QMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEK 508
            Q+ ++Q   + LEK  S   +L+     L   +E ++  K   E   RT+ D  + ++ K
Sbjct: 1210 QIDSLQRVKQKLEKEKS---ELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTK 1266

Query: 509  ERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL-----RNVQT---ECEALKLQMTEK 560
            E   +    E++  ++R+  +  E     +E D +     R  Q    + E LK Q+ E+
Sbjct: 1267 EEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE 1326

Query: 561  DKV--------------IEILRQQIENMTQLVGQHGRTAGAMQVEKAQ----LEKEINDR 602
             K                ++LR+Q E   +   +  R       E AQ     E +   R
Sbjct: 1327 TKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQR 1386

Query: 603  RMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKD-IKQERDQLLNE 661
              EL+E K          ++L  R+ D E E V+ VN+    L   K  ++ E + L+ +
Sbjct: 1387 TEELEEAK----------KKLAQRLQDAE-EHVEAVNSKCASLEKTKQRLQNEVEDLMID 1435

Query: 662  VKTSRSE---LNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSM 718
            V+ S +    L+     ++ +   ++ K EE +      + + +S  +EL + +N  +  
Sbjct: 1436 VERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEE- 1494

Query: 719  EGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQEL 778
                         +    T KR   + LQ +I  L E +    K  H L++ K +L  E 
Sbjct: 1495 ------------SLDHLETLKRENKN-LQQEISDLTEQIAEGGKHIHELEKVKKQLDHEK 1541

Query: 779  STVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLK 838
            S + T   +    LE    +  R++ ++  ++  +D+   +  E  D ++R     V   
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVE-S 1600

Query: 839  LQHTLDIKELQGPGYTSNSSLKPRL-----LQPASVTRSHSNVPSSQSTASFLSHHSTKA 893
            +Q TLD  E++    + N +L+ +      L    +  +H+N  ++++  +  +      
Sbjct: 1601 MQSTLDA-EIR----SRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILK 1655

Query: 894  NTLK--EDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALE---DRVRDCITES 948
            +T    +D  R    L ++L  V  E  A  +    E+ R SL   E         + ++
Sbjct: 1656 DTQLHLDDAIRGQDDLKEQLAMV--ERRANLMQAEVEELRASLERTERGRKMAEQELLDA 1713

Query: 949  SLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSA 1008
            S R  + H  N SL ++    K  ET     ++   G+ ED                   
Sbjct: 1714 SERVQLLHTQNTSLINT---KKKLET----DISQIQGEMEDIV---------------QE 1751

Query: 1009 SRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQ-------SPPIET 1061
            +R+     KK+   + + +        TS +      +   +VKD Q          ++ 
Sbjct: 1752 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKG 1811

Query: 1062 TGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
              K  +KL+ R+  L++ VE  Q  N      +R  E+R++++  Q
Sbjct: 1812 GKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQ 1857



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 129/665 (19%), Positives = 260/665 (39%), Gaps = 69/665 (10%)

Query: 462  KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITK 521
            K+  L    E+ KEM   + EE    K  L  +E    +L   +             +T 
Sbjct: 839  KIKPLLKSAETEKEMAN-MKEEFEKTKEELAKTEAKRKELEEKM-------------VTL 884

Query: 522  LRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQH 581
            ++ + DL+LQ    ++ E D L + +  C+ L     + +  I+ + ++ E+  ++  + 
Sbjct: 885  MQEKNDLQLQ----VQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAEL 940

Query: 582  GRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAG 641
                  ++ E ++L+K+I+D  + L +++  K   + K++ L   ++ L+    KL    
Sbjct: 941  TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000

Query: 642  SERLRA----VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKL 697
                 A    + D++ E D+ +N +  ++++L    ++ E      +    ++E    KL
Sbjct: 1001 KALQEAHQQTLDDLQMEEDK-VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKL 1059

Query: 698  KMQLKSAQSELEQTRN--------------TLKSMEGSDGHAMKVAMGMQKQITAKRGQI 743
            +  LK AQ     T N               + +++G       +A+ +QK+I   + +I
Sbjct: 1060 EGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARI 1119

Query: 744  DALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLK 803
            + L+ +I+   E  + A  EK     ++S LS+EL  ++    +  G         ++ +
Sbjct: 1120 EELEEEIE--AERASRAKAEK-----QRSDLSRELEEISERLEEAGGATSAQIEMNKKRE 1172

Query: 804  EKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRL 863
             +   M   L++++LQ           E  +  L+ +H   + EL G    S   +K +L
Sbjct: 1173 AEFQKMRRDLEESTLQ----------HEATAAALRKKHADSVAEL-GEQIDSLQRVKQKL 1221

Query: 864  LQPASVTRSHSN-VPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVS 922
             +  S  +   N + S+  T S    +  K     ED   ++K   +E + +INE  A  
Sbjct: 1222 EKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQK 1281

Query: 923  LSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTL 982
                 E G  S        R    + ++ S +        +   E  +  E  ++   TL
Sbjct: 1282 ARLHTESGEFS--------RQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTL 1333

Query: 983  HAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSA 1042
                +     C           +  A      S   S V    T     +I  T +   A
Sbjct: 1334 AHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEA 1393

Query: 1043 KPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQL---KNQAMSSMIRNQEK 1099
            K    +  ++D++   +E     C  L+   + LQ  VEDL +   ++ A    +  +++
Sbjct: 1394 KK-KLAQRLQDAEE-HVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQR 1451

Query: 1100 RIQKV 1104
               KV
Sbjct: 1452 NFDKV 1456



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 155/788 (19%), Positives = 307/788 (38%), Gaps = 132/788 (16%)

Query: 390  EKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQ 449
            EKE++  KE+ ++  +           L  ++     E   L+  ++A         ER 
Sbjct: 850  EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERC 909

Query: 450  MAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS----ERTISDLTTSL 505
               I+ K +   K+  +T + E  +E    +  ELTAKK  LE      ++ I DL  +L
Sbjct: 910  DQLIKTKIQLEAKIKEVTERAEDEEE----INAELTAKKRKLEDECSELKKDIDDLELTL 965

Query: 506  QEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIE 565
             + E+   AT  ++  L   +    + +  L  E   L+  +   + L     E+DKV  
Sbjct: 966  AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ--EAHQQTLDDLQMEEDKVNT 1023

Query: 566  I------LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEI-----------NDRRMELKE 608
            +      L QQ++++   + Q  +    ++  K +LE ++           ND++   ++
Sbjct: 1024 LTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEK 1083

Query: 609  LK-----------------ILKDKKDAKIRELEARVSDL--ELEKVKLVNAGSERLRAVK 649
            LK                  L  +   KI+EL+AR+ +L  E+E  +   A +E+ R+  
Sbjct: 1084 LKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRS-- 1141

Query: 650  DIKQERDQLLNEVK------TSRSELNNLSE-EYEVLKRNFRNKSEEMEMTTNKLKMQLK 702
            D+ +E +++   ++      +++ E+N   E E++ ++R+    + + E T   L+ +  
Sbjct: 1142 DLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHA 1201

Query: 703  SAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANK 762
             + +EL +  ++L+          +V   ++K+ +  + +I+ L S ++ + +A  N  K
Sbjct: 1202 DSVAELGEQIDSLQ----------RVKQKLEKEKSELKMEINDLASNMETVSKAKANFEK 1251

Query: 763  EKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQ--------ERRLKEKVTNMEVALD 814
                L+++ S    E+ T   E+ ++  EL   +++         R+L EK   M   L 
Sbjct: 1252 MCRTLEDQLS----EIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK-DAMVSQLS 1306

Query: 815  KASLQFAECQDIIQRQEQESVRLK--LQHTLDIK----ELQGPGYTSNSSLKPRLLQPAS 868
            +    F +  + ++RQ +E  + K  L H L       +L    Y      K  L +  S
Sbjct: 1307 RGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMS 1366

Query: 869  VTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAV-----SL 923
               S          A + + + T A    E+     K+L Q L+       AV     SL
Sbjct: 1367 KANS--------EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASL 1418

Query: 924  SKTEEDGRTSLGALEDRVRDCITESSLRSDMC----HRSNNSLRDSTEGSKSSETLSREP 979
             KT++        L++ V D + +    +  C     +  N  +   E  +  E    E 
Sbjct: 1419 EKTKQ-------RLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAEL 1471

Query: 980  VTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQY 1039
                   R   +  F   +A   S+ +  +    +   +  +  L     EG        
Sbjct: 1472 EASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEG-------- 1523

Query: 1040 RSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEK 1099
               K IH  + VK              ++L +    LQT +E+ +   +     I   + 
Sbjct: 1524 --GKHIHELEKVK--------------KQLDHEKSELQTSLEEAEASLEHEEGKILRIQL 1567

Query: 1100 RIQKVKDQ 1107
             + +VK +
Sbjct: 1568 ELNQVKSE 1575


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  135 bits (341), Expect = 2e-31
 Identities = 195/941 (20%), Positives = 408/941 (43%), Gaps = 116/941 (12%)

Query: 78   RVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRES 137
            + L E   +V+ L+ ++ E  +  E QK  L    +DL+ + QE+ ++++ + ++ +  S
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS 1487

Query: 138  ---------QSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQE 188
                     Q +E      +  + ELE  +  + ++L+    ++E+  +M+ S  G +Q+
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD 1547

Query: 189  IRSILV-------DFEEASGKKICEHDSMSTLH-----FRSLGSAISKILRELDTEISYL 236
            ++  LV       + EE   K  C+   +  L       R   + ++  L E   E+   
Sbjct: 1548 LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607

Query: 237  KGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANS 296
              +I  +E     L  E Q + + +  Q +++IE+L  + E     LT+       +   
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVKSQ-REQIEELQRQKE----HLTQDLERRDQELML 1662

Query: 297  IQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEE---------- 346
             + +++++++Q   Q  +    L  ++ ++ +   EL   +++ +++ EE          
Sbjct: 1663 QKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRG 1722

Query: 347  -LEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL---EKEQ--- 399
             LE   ++   +  E   +++    E   L DQL++ L  LH++  E SL   ++EQ   
Sbjct: 1723 SLEHMKLILRDKEKEVECQQEHI-HELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIV 1781

Query: 400  --NKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSE---CQGQMER---QMA 451
               ++L +      +    L+ +LD     + + +  L+AL+ E    QGQ ER   +  
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841

Query: 452  AIQGKNESLE-KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKER 510
            A+QG  E     +     +L+  KE  R++ EEL  +   +++ E  + DL    +E+E+
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEK 1901

Query: 511  AIEATNAEITKLRSRVDLKLQELQHLKNEGDH-LRNVQTECEALKLQMTEKDKVIEILRQ 569
            A+ A   +  +     +++ + LQ    +    L+    E EAL+ +        E  R 
Sbjct: 1902 ALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961

Query: 570  QIENMTQLVGQ-HGRTAGAMQ--VEKAQLEKEINDRRMELK------ELKILKDKKDAKI 620
            + E + + +G+ H    G  Q  +E+A+L + +      L+      +    + ++  +I
Sbjct: 1962 RAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI 2021

Query: 621  RELEARVSDLELEK--VKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEV 678
            +E E +  DL  ++   +L  A ++R   ++  +QER+QLL +    R + N + E    
Sbjct: 2022 QEGEIQDQDLRYQEDVQQLQQALAQRDEELRH-QQEREQLLEKSLAQRVQENMIQE---- 2076

Query: 679  LKRNFRNKSEEME---MTTNKLKMQLKSAQSELE-------QTRNTLKSMEGSDGHAMKV 728
             K+N   + EE E   +  +  ++QL  AQ E E       Q RN L+++     H+ K 
Sbjct: 2077 -KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALP----HSHKT 2131

Query: 729  AMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELS-TVATEKNK 787
            +   ++ +     ++D+L+ ++Q   E +  A ++    + E  + +Q+L+ ++A  K  
Sbjct: 2132 SPMEEQSL-----KLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKAS 2186

Query: 788  MAGELEVLR----------SQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRL 837
            ++   EV            S+++RL++++     AL+K  L         +   +    +
Sbjct: 2187 VSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGV 2246

Query: 838  KLQHTLDIKELQGPGYTSNSSLKPRL--LQPASVTRSHSNVPSSQSTASFLSHHSTKANT 895
            +L     ++    P      S + RL  LQ A        V   +   S L  H+ +  +
Sbjct: 2247 QLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQA--------VARLEIDRSRLQRHNVQLRS 2298

Query: 896  LKEDPTRDLKQLLQELRSV-----INEEPAVSLSKTEEDGR 931
              E   R+ ++L +E         +    A + S T++DGR
Sbjct: 2299 TLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGR 2339



 Score =  127 bits (320), Expect = 4e-29
 Identities = 203/1046 (19%), Positives = 430/1046 (41%), Gaps = 152/1046 (14%)

Query: 59   VELDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRR-----------------LNESNELH 101
            V  D  ++++    +E   R  +EY+   K+L+R                  L E++ + 
Sbjct: 1020 VAQDDSQRLVEQEVQEKL-RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078

Query: 102  EKQKFYLRQSVIDLQTKLQEM--QME------RDAMADIRRRESQSQEDLR------NQL 147
            +++   LRQ + + Q + +E+  QME      ++  AD   +E+Q  E+L        QL
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL 1138

Query: 148  QNTVHELEAAKCLKEDMLKDSNTQIEQLR-KMMLSHEGVLQ-EIRSILVDFEEASGKKIC 205
            + ++   EA     +  L+ + +Q+E L  +    ++   Q ++ S+    ++A G  +C
Sbjct: 1139 RASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS-VC 1197

Query: 206  EH--------DS-----------------------MSTLHFRSLGSAISKILREL---DT 231
            E         DS                       ++ L   ++ SA+ K+ ++L     
Sbjct: 1198 ESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQ 1257

Query: 232  EISYLKGRIFPVEDQL---EALKSESQNKIELLLQQ-------------HQDRIEQLISE 275
                L+ ++  +E++L   EA KS+   +++ L +Q              Q+ +E  + E
Sbjct: 1258 TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELME 1317

Query: 276  HEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELRE 335
                +  L  +   A  Q    Q + E++Q    N  +    Q+  L++ V + R++   
Sbjct: 1318 LHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA----QVEHLQAAVVEARAQASA 1373

Query: 336  AKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL--------DDQLQKLLADLH 387
            A  + ED        L L N E+ E+  ER Q  QE G L         + L  L   L 
Sbjct: 1374 AGILEED-LRTARSALKLKNEEV-ESERERAQALQEQGELKVAQGKALQENLALLTQTLA 1431

Query: 388  KREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQME 447
            +RE+E+   + Q + L  +       ++ L  +L  RN EV   +  ++ L+ +C+  +E
Sbjct: 1432 EREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELE-KCRSVLE 1490

Query: 448  RQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVE----ELTAKKMTLESSERTISDLTT 503
                A+Q + + L        +LE  +E  R V+E    EL  K   +ES    + DL  
Sbjct: 1491 HLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550

Query: 504  SLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKV 563
             L      +E    E+ +   +++ + + ++ L+ + +  R   T    L L + E+ + 
Sbjct: 1551 QLV----TLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH---LTLDLEERSQE 1603

Query: 564  IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIREL 623
            ++    QI ++          +  +  E  + ++E+  +R +++EL+    +K+   ++L
Sbjct: 1604 LQAQSSQIHDLES-------HSTVLARELQERDQEVKSQREQIEELQ---RQKEHLTQDL 1653

Query: 624  EARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNF 683
            E R  +L L+K ++     +R R  K ++++ +Q+   ++    EL    +  +      
Sbjct: 1654 ERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG 1713

Query: 684  RNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQI------- 736
            +  S+    +   +K+ L+  + E+E  +  +  ++       +   G+ +++       
Sbjct: 1714 KGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLL 1773

Query: 737  TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLR 796
            + +  +I  LQ   Q L+EA      ++  L+ +  +  + L+    E   +  E +  +
Sbjct: 1774 SQREQEIVVLQ---QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQ 1830

Query: 797  SQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSN 856
             QE R+KEK   ++ AL++A +   E    +Q  ++++ RL+ +  ++ + +Q       
Sbjct: 1831 GQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLG 1890

Query: 857  SSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKE---DPTRDLKQLLQELRS 913
                   L+  S  +  + +   Q  A     H  +   L++        LK+  QEL +
Sbjct: 1891 D------LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEA 1944

Query: 914  VINEEPAVSLSKTEEDGRTSLGALEDRV----------RDCITESSLRSDMCHRSNNSLR 963
            +  E  + S    EE  R    AL++ +             + E +  S     S  +L+
Sbjct: 1945 LRAE--SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQ 2002

Query: 964  DSTEGSKSSETLSREPVTLHAGDRED 989
             S +  ++      E + +  G+ +D
Sbjct: 2003 ASLDACQAHSRQLEEALRIQEGEIQD 2028



 Score =  127 bits (319), Expect = 6e-29
 Identities = 209/951 (21%), Positives = 389/951 (40%), Gaps = 136/951 (14%)

Query: 82   EYSHQVKDLQRRLNES---NELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ 138
            E   +V +L   L +S   NE +EK    LR++V  L+T   E+ ME +A      +E +
Sbjct: 280  ELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTEL-MEHEASLSRNAQEEK 338

Query: 139  SQ-------------EDLRNQLQNTVHE--LEA-AKCLKEDMLKDSNTQIEQLRKMMLSH 182
                           E+  N  Q + HE  LE  +    +   +D++  +  +R ++   
Sbjct: 339  LSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRR 398

Query: 183  EGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFP 242
               +Q++R  L   +EA      +HD      +   G A+ + L++L  E   L G+   
Sbjct: 399  RQAVQDLRQQLAGCQEAVNLLQQQHD-----QWEEEGKALRQRLQKLTGERDTLAGQTVD 453

Query: 243  VEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQME 302
            ++ ++++L  E +     LLQ+ ++ + Q +   E E   L       + Q +S Q Q E
Sbjct: 454  LQGEVDSLSKERE-----LLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508

Query: 303  IIQEQ---ARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLV-LANSEL 358
              QE+   A  +       L  LE+  S+  SEL   +   E  +  LE +L+    +E+
Sbjct: 509  EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE--SSHLEGELLRQEQTEV 566

Query: 359  TEARTERDQFSQESGNLDDQLQKLLADLHKREKELS-------LEK-----------EQN 400
            T A    +Q   E  + ++ L+  +ADL     +LS       L+K           E+N
Sbjct: 567  TAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEEN 626

Query: 401  KRLWDR-----DTGNSITID----------------HLRRELDNRNMEVQRLEALLKALK 439
            + +  R        N++ +D                HL  +L         L+A L+ ++
Sbjct: 627  QSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQ 686

Query: 440  ----------SECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKM 489
                      SE + Q E     ++  ++  ++   + A+    KE L   V E  A ++
Sbjct: 687  EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL---VREKAALEV 743

Query: 490  TLESSERTISDLTTSLQEKERAIE----------ATNAEITKLRSRVDLKLQELQHLKNE 539
             L++ ER   DL   LQ    A E            N+ I   + ++++++Q +   K  
Sbjct: 744  RLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEV 803

Query: 540  GDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEI 599
                  +Q E   LKL++  +    E  R           Q G+T  A++ +KA  EKE+
Sbjct: 804  ------IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT--ALEQQKAAHEKEV 855

Query: 600  N--------DRRMELKELKILKDKKDAKIRELEARVSDLELE--------KVKLVNAGSE 643
            N        +R    +EL    +  + +  ELE R+ + + E        + +   A S 
Sbjct: 856  NQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESA 915

Query: 644  RLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKS 703
              +   + ++ER  LL  +  ++ EL + S++ E L+++ + +  + + TT  L+ QL+ 
Sbjct: 916  LCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975

Query: 704  AQSELE----QTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQI----DALQSKIQFLEE 755
            AQ EL+    Q R+ L +++      ++  M +QKQ+   + Q+    D+ +   Q ++E
Sbjct: 976  AQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE 1035

Query: 756  AMTNANKEKHFLKE-EKSKLSQELSTVATEKNKMA-GELEVLRSQERRLKEKVTNMEVAL 813
             +    +     KE E+ K S  LS +  E+  +   E + +R QE  L     +M+ A 
Sbjct: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQE--LSALRQDMQEAQ 1093

Query: 814  DKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSH 873
             +     A+ + + Q  +++      Q    ++EL+    T          Q A   +  
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153

Query: 874  SNVPSSQSTASFLSHHSTKANTLK-EDPTRDLKQLLQE-LRSVINEEPAVS 922
              + S++S    L+      N  + +     L   LQ+ L SV    P +S
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELS 1204



 Score =  121 bits (303), Expect = 4e-27
 Identities = 184/889 (20%), Positives = 381/889 (42%), Gaps = 92/889 (10%)

Query: 80   LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQS 139
            LEE  H+++  Q+ + E     E Q+  L    +DL+ + QE+Q +   + D+   ES S
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL---ESHS 1618

Query: 140  QEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEA 199
               L  +LQ    E+++ +   E++ +      + L +     E +LQ+ R  +++ +  
Sbjct: 1619 TV-LARELQERDQEVKSQREQIEELQRQKEHLTQDLERR--DQELMLQKERIQVLEDQRT 1675

Query: 200  SGKKICEHD-SMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALK---SESQ 255
               KI E D     L  R  G  ++   + +       KG        LE +K    + +
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735

Query: 256  NKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMY 315
             ++E   Q+H   +++L  + E ++ GL  K        +  + ++ ++Q+Q +      
Sbjct: 1736 KEVE-CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE----- 1789

Query: 316  MRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL 375
             R+  +L+     L+S+L EA+R    + +ELE        E  +A+ + ++  +++  L
Sbjct: 1790 AREQGELKE--QSLQSQLDEAQRALAQRDQELE----ALQQEQQQAQGQEERVKEKADAL 1843

Query: 376  DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALL 435
               L++    L +R  EL   KEQ +RL +        +  L   L +   E +  E  L
Sbjct: 1844 QGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL 1903

Query: 436  KALKSECQGQME--------------RQMAAIQGKNESLEKV-----------SSLTAQL 470
             AL+ +C  Q +              +  A ++ +++ LE +            +  A+ 
Sbjct: 1904 LALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA 1963

Query: 471  ESTKEMLRKVVEELTAKKM-TLESSE--RTISDLTTSLQ-----------EKERAIEATN 516
            E+ +E L K    L  K+   LE +E  R++   T +LQ           + E A+    
Sbjct: 1964 EALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023

Query: 517  AEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQ 576
             EI     R    +Q+LQ    + D     Q E E L L+ +   +V E + Q+ +N+ Q
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL-LEKSLAQRVQENMIQEKQNLGQ 2082

Query: 577  ------LVGQHGRTAGAMQVEKAQLEKEINDRR--MELKELKIL--------KDKKDAKI 620
                  + G H ++   +Q+  AQ E+EI + R   +   L+ L         +++  K+
Sbjct: 2083 EREEEEIRGLH-QSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141

Query: 621  RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLK 680
              LE R+   ELE+++     +E  R ++  ++ +D  L+  +T ++ +++L E    L+
Sbjct: 2142 DSLEPRL-QRELERLQAALRQTE-AREIEWREKAQDLALSLAQT-KASVSSLQEVAMFLQ 2198

Query: 681  RNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSME----GSDGHAMKVAMGMQKQI 736
             +   +  E +   ++L++  ++ + E   +     + E    G  G  +    G++ + 
Sbjct: 2199 ASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEP 2258

Query: 737  TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGE-LEVL 795
            +    +  + + +++ L++A+     ++  L+    +L   L  V  E+ K+  E +   
Sbjct: 2259 SPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAA 2318

Query: 796  RSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTS 855
            ++    + +   +     D    + ++ + + + Q +E V L+ Q TL+ K+ Q   Y +
Sbjct: 2319 QAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQ-KEVVLLQAQLTLERKQKQ--DYIT 2375

Query: 856  NSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDL 904
             S+   R L     + SHS +  +Q+  + +    T+   L E  T+ L
Sbjct: 2376 RSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETR--RLDESLTQSL 2422



 Score =  106 bits (265), Expect = 1e-22
 Identities = 222/1110 (20%), Positives = 432/1110 (38%), Gaps = 176/1110 (15%)

Query: 113  IDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQL--QNTVHELEAAKCLKEDMLKDSNT 170
            ++L T+  + + ERDA A   R+ +Q++++ +  L  Q   HE E  + L+E   K+ + 
Sbjct: 813  LELDTERSQAEQERDAAA---RQLAQAEQEGKTALEQQKAAHEKEVNQ-LREKWEKERSW 868

Query: 171  QIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELD 230
              ++L K + S E    E+   L + +        + +   T       SA+ ++  E +
Sbjct: 869  HQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT----QAESALCQMQLETE 924

Query: 231  TE-ISYLKG------RIFPVEDQLEALKS----------ESQNKIELLLQQHQDRIEQLI 273
             E +S L+        +     QLE L+           E+   ++  LQ+ Q  +++  
Sbjct: 925  KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984

Query: 274  SEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSEL 333
             +H  ++  L E++SS       +Q Q+E ++ Q   Q+        +++  + + +   
Sbjct: 985  RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYN 1044

Query: 334  REAKRMYEDKT-------EELEKQLVLANS------ELTEARTERDQFSQESGNLDDQLQ 380
            R  K +  +K        E+ ++ LVL  +      EL+  R +  +   E   L  Q++
Sbjct: 1045 RIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQME 1104

Query: 381  KLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKS 440
             L  ++ ++E +   ++ Q   L +    + IT   LR  L  +  +  +L+  L++ +S
Sbjct: 1105 LLRQEVKEKEADFLAQEAQ---LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161

Query: 441  EC-----------QGQMERQMAAI----------------------------------QG 455
            +            Q Q + Q+A++                                  Q 
Sbjct: 1162 QLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQN 1221

Query: 456  KNESLEKVSSLTAQL--ESTKEMLRKVVEELTAKKMT--------------LESSERTIS 499
               SL K   L   L  E+    L K+ ++L   + T              L  +E   S
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKS 1281

Query: 500  DLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTE 559
             + T LQ+ +R +     E +K   + +    EL  L    + + ++Q+     +LQ  E
Sbjct: 1282 QVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELH---ETMASLQSRLRRAELQRME 1338

Query: 560  KDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQ----LEKEINDRRMELKELKILKDK 615
                 E+L+   EN+T  V +H + A      +A     LE+++   R  LK    LK++
Sbjct: 1339 AQGERELLQAAKENLTAQV-EHLQAAVVEARAQASAAGILEEDLRTARSALK----LKNE 1393

Query: 616  KDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEE 675
            +    RE    + +    KV    A  E L  +     ER++   EV+T R ++  L ++
Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREE---EVETLRGQIQELEKQ 1450

Query: 676  YEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQ 735
             E+ K      S +++    ++ +Q +  Q ELE+ R+ L+       H        +++
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQ-ELEKCRSVLE-------HLPMAVQEREQK 1502

Query: 736  ITAKRGQIDAL----QSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGE 791
            +T +R QI  L    +++   LE  +    K+   ++ ++ ++ Q+L         +A E
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV-QDLKKQLVTLECLALE 1561

Query: 792  LE----VLRSQERRLKEKVTNME---VALDKASLQFAECQDIIQRQEQESVRLKLQHTLD 844
            LE     +  Q++ +KE     E   VAL   +L   E    +Q Q  +   L+   T+ 
Sbjct: 1562 LEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621

Query: 845  IKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDL 904
             +ELQ      +  +K +  Q   + R                    K +  ++   RD 
Sbjct: 1622 ARELQ----ERDQEVKSQREQIEELQRQ-------------------KEHLTQDLERRDQ 1658

Query: 905  KQLLQELRSVINEEPAVSLSK-TEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
            + +LQ+ R  + E+     +K  EED      +L +R R+  T+  L  +          
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERA-------- 1710

Query: 964  DSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHS 1023
            +  +G   ++  S E + L   D+E    C          +K+   +      +K    S
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770

Query: 1024 LLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDL 1083
            LL S  E  I    Q +  +     +  + S    ++   +   +    LE+LQ      
Sbjct: 1771 LLLSQREQEI-VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ----QE 1825

Query: 1084 QLKNQAMSSMIRNQEKRIQKVKDQEKMLLK 1113
            Q + Q     ++ +   +Q   +Q  M LK
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLK 1855



 Score =  102 bits (254), Expect = 2e-21
 Identities = 161/794 (20%), Positives = 333/794 (41%), Gaps = 139/794 (17%)

Query: 102  EKQKFYLRQSVIDLQTKLQEMQME-RDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCL 160
            EK++  L +    L+ +LQ+ +    +  AD+R  + + +E+++ +L  + H+ EAA   
Sbjct: 651  EKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE-KEEIQKKLSESRHQQEAATTQ 709

Query: 161  KEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEE---------------ASGKKIC 205
             E + +++  Q E L + +   E +++E  ++ V  +                +S K++ 
Sbjct: 710  LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL 769

Query: 206  EHDSMSTLHFRSLGSAISKILRELDTEIS-------YLKGRIFPVEDQLEALKSESQNKI 258
            E    S    +   S I     +L+ +I         ++G +  ++ +L+  +S+++ + 
Sbjct: 770  ES---SLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826

Query: 259  ELLL-------QQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQ 311
            +          Q+ +  +EQ  + HE E+  L EK    RS            QE A+  
Sbjct: 827  DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ---------QELAKAL 877

Query: 312  NSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQE 371
             S+  R+  +LE  + + ++E+   +   E++  + E  L     E     TE+++ S  
Sbjct: 878  ESL-EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLE-----TEKERVS-- 929

Query: 372  SGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRL 431
                      LL  L + +KEL+   +Q              ++ LR+++  + ++ Q  
Sbjct: 930  ----------LLETLLQTQKELADASQQ--------------LERLRQDMKVQKLKEQET 965

Query: 432  EALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTL 491
              +L+    E Q +++    A +   + L  +   ++ L   K  L+K VE+L ++ +  
Sbjct: 966  TGILQTQLQEAQRELKE---AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQ 1022

Query: 492  ESSERTISDLTTSLQEKERAIEATN---AEITKLRSRVDLKLQELQH---LKNEGDHLRN 545
            + S+R +      +QEK R  +  N    E+ + ++ + L L E +    +  E D +R 
Sbjct: 1023 DDSQRLVEQ---EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR- 1078

Query: 546  VQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRME 605
             Q E  AL+  M E     + L  Q+E + Q V +          ++AQL +E+    + 
Sbjct: 1079 -QQELSALRQDMQEAQGEQKELSAQMELLRQEVKE---KEADFLAQEAQLLEELEASHIT 1134

Query: 606  LKELKILKDKKDAKIRELEARV--SDLELEKVKLVNAGSERLRA---VKDIKQERDQLLN 660
             ++L+     ++AK  +L+ R+  ++ +LE +        + +A   +  +     Q L 
Sbjct: 1135 EQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALG 1194

Query: 661  EVKTSRSELN----------NLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQ 710
             V  SR EL+           L  +    +  F+       ++   +   L     +L +
Sbjct: 1195 SVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWK 1254

Query: 711  TRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEE 770
            T+ T                             D L+ ++Q LEE +T+   EK  +  E
Sbjct: 1255 TQQTR----------------------------DVLRDQVQKLEERLTDTEAEKSQVHTE 1286

Query: 771  KSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQ---DII 827
               L ++LS    EK+K  G+   L S+   L E + +++  L +A LQ  E Q   +++
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL 1346

Query: 828  QRQEQESVRLKLQH 841
            Q   +E++  +++H
Sbjct: 1347 Q-AAKENLTAQVEH 1359



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 166/829 (20%), Positives = 336/829 (40%), Gaps = 95/829 (11%)

Query: 82  EYSHQVKDLQRRLNESN-ELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIR---RRES 137
           +Y    ++L++RL  +   + ++ +     ++ +L  +L+E Q   +++A++    R   
Sbjct: 65  QYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHM 124

Query: 138 QSQEDLRNQLQNTVHELEA--AKCLKEDMLKDSNTQIEQ--LRKMMLSHEGVLQEIRSIL 193
           +  + +   L+  V +L    ++   E M K+S  Q+EQ   +  +    G L  +   +
Sbjct: 125 EKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREV 184

Query: 194 VDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQL----EA 249
           V F                 HF  + SA  + L EL  E   L G +     +L    ++
Sbjct: 185 VTFRR---------------HFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQS 229

Query: 250 LKSESQNKIE-------LLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQME 302
            +     +++       LLL      +E+   E   E+  L  +    +++     +++ 
Sbjct: 230 REPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELS 289

Query: 303 IIQEQARNQNSMYMRQLSDLESTVSQLRS---ELREAKRMYEDKTEELEKQLVLANSELT 359
            +  Q++ QN  Y + +  L  TV  L +   EL E +       +E +  L     ++T
Sbjct: 290 ALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDIT 349

Query: 360 EARTER-DQFSQESGN-----LDDQLQKLLADLHKREKELSLEKEQNKR-------LWDR 406
           +   E  D  +Q SG+     LD  +     D    +K L+L +    R       L  +
Sbjct: 350 QVMVEEGDNIAQGSGHENSLELDSSIFSQF-DYQDADKALTLVRSVLTRRRQAVQDLRQQ 408

Query: 407 DTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSL 466
             G    ++ L+++ D    E + L   L+ L  E +  +  Q   +QG+ +SL K    
Sbjct: 409 LAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGE-RDTLAGQTVDLQGEVDSLSK---- 463

Query: 467 TAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ--------EKERAIEATNAE 518
                  +E+L+K  EEL  +   LE     +  +   LQ        +KE   E  +  
Sbjct: 464 ------ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLA 517

Query: 519 ITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLV 578
           + + R R+   L  L+  ++E   L  + T  EAL+    E     E+LRQ+   +T  +
Sbjct: 518 VRE-RERLQEMLMGLEAKQSES--LSELITLREALESSHLEG----ELLRQEQTEVTAAL 570

Query: 579 GQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKL- 637
            +  ++   +   +  L+ E+ D R    +L  L +        L  ++  LE E   + 
Sbjct: 571 ARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVC 630

Query: 638 --VNAGSERLRAVK----DIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEME 691
             + A  +   A++    + ++ R+ L  +     ++L    E    L+ + R+  EE E
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE 690

Query: 692 MTTNKL---KMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQS 748
               KL   + Q ++A ++LEQ     K  E     A++    + ++  A   ++ A++ 
Sbjct: 691 EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVER 750

Query: 749 KIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTN 808
             Q L E +   +  K  L+    +  Q+ S +   K ++  +++ +   +  ++ +V  
Sbjct: 751 DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRC 810

Query: 809 MEVALDKASLQFAECQDIIQRQ----EQES----VRLKLQHTLDIKELQ 849
           +++ LD    Q  + +D   RQ    EQE      + K  H  ++ +L+
Sbjct: 811 LKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR 859


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  134 bits (337), Expect = 5e-31
 Identities = 211/903 (23%), Positives = 380/903 (42%), Gaps = 165/903 (18%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERD----- 127
            KE  + +LE  +     L+     S++LHE +K  L+     L+ KL +M+MERD     
Sbjct: 350  KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKK 404

Query: 128  -----------AMADIR---------------RRESQSQEDLRNQLQNTVHELEAAKCLK 161
                        MA  +                R S+  E  +  L + V+EL +++ LK
Sbjct: 405  IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464

Query: 162  EDMLKDSNTQ-IEQLRKMMLSHEGVLQEIRSILVDFEEASGK-KICEHDSMSTLHFRSLG 219
             +M   S T+ +E+LR  + S EG   +I  +  + +  S K +I E++ +         
Sbjct: 465  LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524

Query: 220  SAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVE 279
              +SK L +   ++          E  +E L+  S+ +I+ +L+Q  + + Q +S     
Sbjct: 525  QNLSKDLMKEKAQL----------EKTIETLRENSERQIK-ILEQENEHLNQTVS----- 568

Query: 280  ITGLTEKAS-SARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKR 338
               L +++  SA ++   I+ + +I+ E  +  +S    +LS +E    Q++ EL   K 
Sbjct: 569  --SLRQRSQISAEARVKDIEKENKILHESIKETSS----KLSKIEFEKRQIKKELEHYKE 622

Query: 339  MYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKE 398
              E + EELE       +EL     E +   ++  NL    +K+ A L +   EL  E  
Sbjct: 623  KGE-RAEELE-------NELHHLEKENELLQKKITNLKITCEKIEA-LEQENSELERENR 673

Query: 399  QNKRLWDRDTGNSITIDHLRRE---LDNRNMEVQRLEALLKALKSECQGQMERQMAAIQG 455
            + K+  D     +  ++ L +E   LD  N+E++R    LK            +MA +Q 
Sbjct: 674  KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC--------ASMKMAQLQL 725

Query: 456  KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEAT 515
            +N+          +LES KE L+K +E L A     E  E +   L    Q  ++ +E +
Sbjct: 726  ENK----------ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775

Query: 516  NAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMT 575
            N +I +L S       ELQ L+ E    + +Q   E LK+      K +E L ++ +++ 
Sbjct: 776  NKKIQQLES-------ELQDLEMEN---QTLQKNLEELKI----SSKRLEQLEKENKSLE 821

Query: 576  QLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKV 635
            Q              E +QLEK+      E K L+   + KD  + E   ++ +LE E  
Sbjct: 822  Q--------------ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867

Query: 636  KL---VNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEM 692
             L   +    E    +K++++E  +L+         L  L E+    K   +  + ++E 
Sbjct: 868  TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 693  TTNKLK---MQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSK 749
             T++L+   +  +    + + T +  K +E       K+   ++K +  K  +I AL+++
Sbjct: 928  LTHELEKIGLNKERLLHDEQSTDDRYKLLES------KLESTLKKSLEIKEEKIAALEAR 981

Query: 750  I-------QFLEEAMTNANKEKHFLK--EEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
            +       Q L + +    K    LK  +++ ++ Q    ++ E NK   E E   +   
Sbjct: 982  LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW--ERESQETTRE 1039

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLK 860
             LK K   +EV  + A+LQ             E   LK Q    +K+L+    T N++L+
Sbjct: 1040 LLKVKDRLIEVERNNATLQ------------AEKQALKTQ----LKQLE----TQNNNLQ 1079

Query: 861  PRL--LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEE 918
             ++  LQ  +V+    N       A     +ST  N+          QLL +  S+ NE 
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENST-LNSQSTSLMNQNAQLLIQQSSLENEN 1138

Query: 919  PAV 921
             +V
Sbjct: 1139 ESV 1141



 Score =  127 bits (318), Expect = 8e-29
 Identities = 200/965 (20%), Positives = 408/965 (42%), Gaps = 122/965 (12%)

Query: 77   ERVLEEYSHQVKDLQRRLNESNELH----EKQKFYLRQSVIDLQTKLQEMQMERDAMA-- 130
            E+  E  +  V  L++R   S E      EK+   L +S+ +  +KL +++ E+  +   
Sbjct: 557  EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616

Query: 131  -DIRRRESQSQEDLRNQLQNTVHELEAAK---------CLKEDMLKDSNTQIEQ----LR 176
             +  + + +  E+L N+L +   E E  +         C K + L+  N+++E+    L+
Sbjct: 617  LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676

Query: 177  KMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYL 236
            K + S + +  ++ S+     E    ++ E +     +  SL  A  K + +L  E   L
Sbjct: 677  KTLDSFKNLTFQLESL-----EKENSQLDEENLELRRNVESLKCASMK-MAQLQLENKEL 730

Query: 237  KGRIFPVEDQLEALKSESQNKIELLLQQHQ------DRIEQLISEHEVEITGLTEKASSA 290
            +     ++  LE LK+ S  K E L   +Q       R+++ +     +I  L  +    
Sbjct: 731  ESEKEQLKKGLELLKA-SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789

Query: 291  RSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQ 350
              +  ++Q  +E ++  ++      + QL     ++ Q  S+L + K+  E + + L +Q
Sbjct: 790  EMENQTLQKNLEELKISSKR-----LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844

Query: 351  LVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGN 410
              + ++ L E   +     +E+  L  ++  +  +   R KEL   +++NK L  R T +
Sbjct: 845  AEIKDTTLEENNVKIGNLEKENKTLSKEIG-IYKESCVRLKEL---EKENKELVKRATID 900

Query: 411  SITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQL 470
              T+  LR +L +  ++ Q++   L+ L  E +     +   +  +  + ++   L ++L
Sbjct: 901  IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL 960

Query: 471  EST-KEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLK 529
            EST K+ L    E++ A +  LE S      L   L+  ++     N E  K R   +  
Sbjct: 961  ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK-----NYEALKQRQDEERM 1015

Query: 530  LQELQHLKNEGD--HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGA 587
            +Q    +  E +     + +T  E LK+    KD++IE+ R       +          A
Sbjct: 1016 VQSSPPISGEDNKWERESQETTRELLKV----KDRLIEVERNNATLQAE--------KQA 1063

Query: 588  MQVEKAQLEKEINDRRMELKELK---ILKDKKDAKIRELEARV----SDLELEKVKLVNA 640
            ++ +  QLE + N+ + ++  L+   +   +++  ++   A++    S L  +   L+N 
Sbjct: 1064 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1123

Query: 641  GSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQ 700
             ++ L     ++ E + ++ E +  +S  ++L +++E L+     ++ E E   +K    
Sbjct: 1124 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK-HGT 1182

Query: 701  LKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNA 760
            LKSA   LE     L+                  Q+  ++GQ++ L+  ++  +E M   
Sbjct: 1183 LKSAHKNLEVEHRDLEDR--------------YNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228

Query: 761  NKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQF 820
            NK    +  E  KL  E   +    +++  E EVL++  + LK  + N ++   +   +F
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1288

Query: 821  AECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRL--LQPASVTRSHSNVPS 878
            ++ ++  Q+ +  S +L  Q  L + +L+G     N  L  ++  L   + T    N+ S
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCEL-LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES 1347

Query: 879  SQSTASFLSHHSTKANTLKE----------------DP----------TRDLKQLLQELR 912
                      +  K N L+                 DP          T  +++L++  +
Sbjct: 1348 KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKK 1407

Query: 913  SVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRD-STEGSKS 971
              IN E   SL+ T     +S G L+   +D    SS+ S       NSL D  T G+K 
Sbjct: 1408 D-INRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGS-------NSLEDGQTLGTKK 1459

Query: 972  SETLS 976
            S  ++
Sbjct: 1460 SSMVA 1464



 Score =  116 bits (291), Expect = 1e-25
 Identities = 214/946 (22%), Positives = 394/946 (41%), Gaps = 157/946 (16%)

Query: 232  EISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISE---HEVEITGLTEKAS 288
            E+++ +  +F +  Q   +   SQ  IE LL+     +++LI E   H   I  L+E+  
Sbjct: 162  EVTHNQENVFDL--QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERD 219

Query: 289  S------ARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED 342
                   A S A S      + + ++R   S+   +L+D ++ + +LR EL E      D
Sbjct: 220  GLHFLPHASSSAQSPCGSPGMKRTESRQHLSV---ELADAKAKIRRLRQELEEKTEQLLD 276

Query: 343  KTEELE------KQLVLAN----SELTEARTERDQFSQESGNLDDQLQKLLADLHKREKE 392
              +ELE      K+L   N    S+   AR  RD+         D L++    + K E E
Sbjct: 277  CKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL--------DALREKAVRVDKLESE 328

Query: 393  LSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAA 452
            +S  KE   RL D        I+  +  ++    + Q L      L+ + +G   R    
Sbjct: 329  VSRYKE---RLHD--------IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377

Query: 453  IQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISD----LTTSLQEK 508
             + + E+L+  + L   +E  ++M RK +EEL  + MTLE +++   D    L   L++ 
Sbjct: 378  HELEKENLQLKAKL-HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436

Query: 509  ERAIEATNA-------EITKLRSRVDLKLQ-ELQHLKNEGDHLRNV--QTECEALKLQMT 558
             R  E + A       E+ +L S   LKL+ E Q L    + LR      E  A K+   
Sbjct: 437  SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496

Query: 559  EKD-----KVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIND-RRMELKELKIL 612
            EK+     K +EIL  +I    Q +      +  +  EKAQLEK I   R    +++KIL
Sbjct: 497  EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556

Query: 613  KDKKD------AKIRE-----LEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
            + + +      + +R+      EARV D+E E   L  +  E    +  I+ E+ Q+  E
Sbjct: 557  EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616

Query: 662  VKTSR----------SELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQT 711
            ++  +          +EL++L +E E+L++   N    +++T  K++  L+   SELE+ 
Sbjct: 617  LEHYKEKGERAEELENELHHLEKENELLQKKITN----LKITCEKIE-ALEQENSELERE 671

Query: 712  RNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEK 771
               LK             +   K +T    Q+++L+ +   L+E      +    LK   
Sbjct: 672  NRKLKK-----------TLDSFKNLTF---QLESLEKENSQLDEENLELRRNVESLKCAS 717

Query: 772  SKLSQ---ELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQ 828
             K++Q   E   + +EK ++   LE+L++  +    K   +EV+     ++    Q  ++
Sbjct: 718  MKMAQLQLENKELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLE 773

Query: 829  RQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSH 888
               ++  +L+     ++++L+    T   +L+   +    + +      S +   S L  
Sbjct: 774  NSNKKIQQLE----SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE- 828

Query: 889  HSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITES 948
                         +D KQL +E + +   + A     T E+    +G LE   +    E 
Sbjct: 829  -------------KDKKQLEKENKRL--RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873

Query: 949  SLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSA 1008
             +  + C R     +++ E  K +    +  VTL    RED           S  +K   
Sbjct: 874  GIYKESCVRLKELEKENKELVKRATIDIKTLVTL----RED---------LVSEKLK--- 917

Query: 1009 SRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRK 1068
            ++  N+  +K      LT  +E  IG   +        + D  K  +S    T  K+   
Sbjct: 918  TQQMNNDLEK------LTHELE-KIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEI 970

Query: 1069 LQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVK---DQEKML 1111
             + ++ +L+  +E+    NQ +   ++  +K  + +K   D+E+M+
Sbjct: 971  KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 151/809 (18%), Positives = 332/809 (41%), Gaps = 141/809 (17%)

Query: 341  EDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLAD-----LHKREKELSL 395
            E  TEE++K L+L      + + ++++F +    LD   +  +A       H +E    L
Sbjct: 115  EQGTEEVKKLLLLLLGCAVQCQ-KKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173

Query: 396  EKEQNKRLWDRDTGNSIT--IDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAI 453
            +  +   +   D    +     HL+R +D R+   +  E +++ L  E  G      A+ 
Sbjct: 174  QWMEVTDMSQEDIEPLLKNMALHLKRLIDERD---EHSETIIE-LSEERDGLHFLPHASS 229

Query: 454  QGKN-------ESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ 506
              ++       +  E    L+ +L   K  +R++ +EL  K              T  L 
Sbjct: 230  SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEK--------------TEQLL 275

Query: 507  EKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEI 566
            + ++ +E    E+ +L+       QE  +L ++    R  + E +AL+ +    DK+   
Sbjct: 276  DCKQELEQMEIELKRLQ-------QENMNLLSDARSARMYRDELDALREKAVRVDKLESE 328

Query: 567  LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDA------KI 620
            + +  E +  +           +  KA++E+   D ++ L+   +L+D+ +       K+
Sbjct: 329  VSRYKERLHDI-----------EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377

Query: 621  RELE-------ARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLS 673
             ELE       A++ D+E+E+        E +     ++  + Q ++E      EL  +S
Sbjct: 378  HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437

Query: 674  EEYEVLKRNFRNKSEEMEMTTN----KLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVA 729
               E+ +   ++   E+   T+    KL+M+ +S    +E+ R T+ S+EG+    +K  
Sbjct: 438  RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK-- 495

Query: 730  MGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMA 789
              M+K+      +++ L+++I   ++++ N       L +EK++L +   T+ T +    
Sbjct: 496  --MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK---TIETLRENSE 550

Query: 790  GELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQ 849
             ++++L  +   L + V+    +L + S   AE +  ++  E+E+   K+ H   IKE  
Sbjct: 551  RQIKILEQENEHLNQTVS----SLRQRSQISAEAR--VKDIEKEN---KILHE-SIKE-- 598

Query: 850  GPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLS---HHSTKANTLKEDPTRDLKQ 906
                 ++S L     +   + +   +       A  L    HH  K N L +    +LK 
Sbjct: 599  -----TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653

Query: 907  LLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSL-RDS 965
              +++ ++  E      S+ E + R     L     D     + + +   + N+ L  ++
Sbjct: 654  TCEKIEALEQEN-----SELERENRKLKKTL-----DSFKNLTFQLESLEKENSQLDEEN 703

Query: 966  TEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLL 1025
             E  ++ E+L    + +                 A   ++N    S     KK     LL
Sbjct: 704  LELRRNVESLKCASMKM-----------------AQLQLENKELESEKEQLKKG--LELL 744

Query: 1026 TSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQL 1085
             +S          ++  + +  S    D ++  ++   KT      +++ L++ ++DL++
Sbjct: 745  KAS----------FKKTERLEVSYQGLDIENQRLQ---KTLENSNKKIQQLESELQDLEM 791

Query: 1086 KNQAMSSMIRN---QEKRIQKVKDQEKML 1111
            +NQ +   +       KR+++++ + K L
Sbjct: 792  ENQTLQKNLEELKISSKRLEQLEKENKSL 820


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  134 bits (337), Expect = 5e-31
 Identities = 189/958 (19%), Positives = 399/958 (41%), Gaps = 112/958 (11%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L  K K  L Q V DL+  L++   E+    D+ R + + +
Sbjct: 1003 EAHQQALDDLQVEEDKVNSL-SKSKVKLEQQVDDLEGSLEQ---EKKVRMDLERAKRKLE 1058

Query: 141  EDLRNQLQNTVHELEAAKCLKEDMLK-------DSNTQIEQLRKMMLSHEGVLQEIRSIL 193
             DL+   Q ++ +LE  K   E+ LK         N++IE  + + L  +  L+E ++ +
Sbjct: 1059 GDLK-LTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARI 1117

Query: 194  VDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSE 253
             + EE       E +  +      L S +S+ L E+   +    G          +++ E
Sbjct: 1118 EELEEE-----LEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT--------SVQIE 1164

Query: 254  SQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNS 313
               K E   Q+ +  +E+   +HE     L +K + + ++       ++ ++++   + S
Sbjct: 1165 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1224

Query: 314  MYMRQLSDLESTVSQL---RSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQ 370
             +  +L D+ S + Q+   ++ L +  R  ED+  E   +L  A   L +  T+R +   
Sbjct: 1225 EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284

Query: 371  ESGNLDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH----------- 416
            E+G L  QL++   L++ L + +   + + E  KR  + +      + H           
Sbjct: 1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL 1344

Query: 417  LRRELDNRNMEVQRLEALLKALKSE-CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKE 475
            LR + +        L+ +L    SE  Q + + +  AIQ   E  E    L  +L+  +E
Sbjct: 1345 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1404

Query: 476  MLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAE---ITKLRSRVDLKLQE 532
             +  V  + ++ + T    +  I DL   ++    A  A + +     K+ +    K +E
Sbjct: 1405 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1464

Query: 533  LQ-HLKNEGDHLRNVQTECEALKLQMTEKDKVIEI-------LRQQIENMTQLVGQHGRT 584
             Q  L++     R++ TE   LK    E  + +E        L+++I ++T+ +G+ G+ 
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524

Query: 585  AGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKI-----------RELEARVS--DLE 631
               ++  + QLE E  + +  L+E +   + ++ KI            E+E +++  D E
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEE 1584

Query: 632  LEKVKL------------VNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVL 679
            +E+ K             ++A +     V  +K++ +  LNE++   S  N ++ E +  
Sbjct: 1585 MEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ 1644

Query: 680  KRNFRNKSEEMEM-------TTNKLKMQLKSA-------QSELEQTRNTLKSMEGSDGHA 725
             ++ ++  ++ ++         + LK  +          Q+ELE+ R  ++  E S   A
Sbjct: 1645 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA 1704

Query: 726  MKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEK 785
             +  +   +++     Q  +L ++ + +E  +T    E     +E     ++     T+ 
Sbjct: 1705 EQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDA 1764

Query: 786  NKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDI 845
              MA EL+  +     L+    NME  +     +  E + I  +  ++ ++ KL+    +
Sbjct: 1765 AMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ-KLE--ARV 1821

Query: 846  KELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLK 905
            +EL+G                A   R+  +V   + +   +   + +    K++  R L+
Sbjct: 1822 RELEGE-------------LEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR-LQ 1867

Query: 906  QLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
             L+ +L+  +         + EE   T+L     +V+  + E+  R+D+     N LR
Sbjct: 1868 DLVDKLQLKVKAYKR-QAEEAEEQANTNLSKFR-KVQHELDEAEERADIAESQVNKLR 1923



 Score =  121 bits (303), Expect = 4e-27
 Identities = 221/1093 (20%), Positives = 442/1093 (40%), Gaps = 170/1093 (15%)

Query: 114  DLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIE 173
            ++ T  +E    ++ +     R  + +E + + LQ   ++L+     ++D L D+  + +
Sbjct: 850  EMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEK-NDLQLQVQAEQDNLNDAEERCD 908

Query: 174  QLRKMMLSHEGVLQEIRSILVDFEE------ASGKKICEHDSMSTLHFRSLGSAISKILR 227
            QL K  +  E  ++E+   L D EE      A  +K+ +  S        L   ++K+ +
Sbjct: 909  QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 968

Query: 228  E----------LDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHE 277
            E          L  E++ L   I  +  + +AL+   Q  ++ L Q  +D++  L S+ +
Sbjct: 969  EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-QVEEDKVNSL-SKSK 1026

Query: 278  VEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAK 337
            V++    +    +  Q   ++  +E  + +      +    + DLE+   QL  +L++ +
Sbjct: 1027 VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKE 1086

Query: 338  RMYEDKTEELEKQLVLA-----------------NSELTEARTERDQFSQESGNLDDQLQ 380
                 +  ++E + VLA                   EL   RT R +  +   +L  +L+
Sbjct: 1087 FDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE 1146

Query: 381  KLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKS 440
            ++   L +     S++ E NK+              +RR+L+   ++ +   A L+   +
Sbjct: 1147 EISERLEEAGGATSVQIEMNKK-------REAEFQKMRRDLEEATLQHEATAAALRKKHA 1199

Query: 441  ECQGQMERQMAAIQGKNESLEK-----------VSSLTAQLESTKEMLRKVVEELTAK-- 487
            +   ++  Q+  +Q   + LEK           V+S   Q+   K  L KV   L  +  
Sbjct: 1200 DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQAN 1259

Query: 488  --KMTLESSERTISDLTTS--------------LQEKERAI-EATNAEITKLRSRVDLK- 529
              ++ LE ++R+++D TT               L+EKE  I + T  +++  +   DLK 
Sbjct: 1260 EYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKR 1319

Query: 530  -LQELQHLKNEGDH-LRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGA 587
             L+E    KN   H L++ + +C+ L+ Q  E+ +    L++ +      V Q       
Sbjct: 1320 QLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW------ 1373

Query: 588  MQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA 647
                + + E +   R  EL+E K          ++L  R+ D E E V+ VNA    L  
Sbjct: 1374 ----RTKYETDAIQRTEELEEAK----------KKLAQRLQDAE-EAVEAVNAKCSSLEK 1418

Query: 648  VKD-IKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQS 706
             K  ++ E + L+ +V+ S +    L ++    +RNF     E +    + + +L+S+Q 
Sbjct: 1419 TKHRLQNEIEDLMVDVERSNAAAAALDKK----QRNFDKILAEWKQKYEESQSELESSQK 1474

Query: 707  ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHF 766
            E       L  ++ +   +++        +   + +   LQ +I  L E +    K  H 
Sbjct: 1475 EARSLSTELFKLKNAYEESLE-------HLETFKRENKNLQEEISDLTEQLGEGGKNVHE 1527

Query: 767  LKEEKSKLSQELSTVATEKNKMAGELE-----VLRSQ----------ERRLKEKVTNMEV 811
            L++ + +L  E   + +   +    LE     +LR+Q          ER+L EK   ME 
Sbjct: 1528 LEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1587

Query: 812  ALDKASLQFAECQ---DIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPAS 868
            A           Q   D   R   E +R+K +   D+ E++     +N        Q  S
Sbjct: 1588 AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1647

Query: 869  VTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQL-LQELRSVINE-EPAVSLSKT 926
            + +S       Q   +  ++   K N    +   +L Q  L+ELR+V+ + E +  L++ 
Sbjct: 1648 L-QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ 1706

Query: 927  EEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGD 986
            E                 + E+S R  + H  N SL +  +  +S  T  +  V      
Sbjct: 1707 E-----------------LIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV------ 1743

Query: 987  REDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSL--LTSSVEGSIGSTSQYRSAKP 1044
             E    C      A  ++ ++A  +     ++     L  +  ++E +I    Q+R    
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL-QHR---- 1798

Query: 1045 IHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKV 1104
                  + +++   ++   K  +KL+ R+  L+  +E  Q +N      +R  E+RI+++
Sbjct: 1799 ------LDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKEL 1852

Query: 1105 ----KDQEKMLLK 1113
                ++ +K LL+
Sbjct: 1853 TYQTEEDKKNLLR 1865



 Score =  107 bits (267), Expect = 6e-23
 Identities = 176/942 (18%), Positives = 377/942 (40%), Gaps = 118/942 (12%)

Query: 228  ELDTEISYLK---GRIFPVEDQLEALKSESQNKIELLLQQHQD----------------- 267
            E + E++ +K   GRI    ++ EA + E + K+  LLQ+  D                 
Sbjct: 846  ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905

Query: 268  RIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVS 327
            R +QLI ++++++    ++ +        + +++   + +  ++ S   + + DLE T++
Sbjct: 906  RCDQLI-KNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLA 964

Query: 328  QLRSELREAKRMYEDKTEELE------KQLVLANSELTEARTERDQFSQESGNLDDQLQK 381
            ++  E    +   ++ TEE+        +L      L EA  +     Q   +  + L K
Sbjct: 965  KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024

Query: 382  LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSE 441
                L ++  +L    EQ K++        + ++  +R+L+      Q     L+  K +
Sbjct: 1025 SKVKLEQQVDDLEGSLEQEKKV-------RMDLERAKRKLEGDLKLTQESIMDLENDKLQ 1077

Query: 442  CQGQMERQMAAIQGKNESLEKVSSLTAQLE----STKEMLRKVVEELTAKKMTLESSERT 497
             + +++++   I  +N  +E    L  QL+      +  + ++ EEL A++      E+ 
Sbjct: 1078 LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKL 1137

Query: 498  ISDLTTSLQE-KERAIEATNAEITKLRSRVDLKLQ-ELQHLKNEGDHLRNVQTECEALKL 555
             SDL+  L+E  ER  EA  A  T ++  ++ K + E Q ++ + +    +Q E  A  L
Sbjct: 1138 RSDLSRELEEISERLEEAGGA--TSVQIEMNKKREAEFQKMRRDLEE-ATLQHEATAAAL 1194

Query: 556  QMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKEL------ 609
            +    D V E L +QI+N+        R    ++ EK++ + E++D    ++++      
Sbjct: 1195 RKKHADSVAE-LGEQIDNLQ-------RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1246

Query: 610  -----KILKDKKD---AKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
                 + L+D+ +    K+ E +  ++D   ++ KL     E  R +    +E++ L+++
Sbjct: 1247 LEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQL----EEKEALISQ 1302

Query: 662  VKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGS 721
            +  +R +L + +++ E LKR      EE     N L   L+SA+ + +  R   +    +
Sbjct: 1303 L--TRGKL-SYTQQMEDLKRQL----EEEGKAKNALAHALQSARHDCDLLREQYEEETEA 1355

Query: 722  DGHAMKVAMGMQKQITAKRG--QIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELS 779
                 +V      ++   R   + DA+Q + + LEEA     +     +E    ++ + S
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQ-RTEELEEAKKKLAQRLQDAEEAVEAVNAKCS 1414

Query: 780  TVATEKNKMAGELEVLRSQERR-------LKEKVTNMEVALDKASLQFAECQDIIQRQEQ 832
            ++   K+++  E+E L     R       L +K  N +  L +   ++ E Q  ++  ++
Sbjct: 1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474

Query: 833  ESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTK 892
            E+  L    + ++ +L+     S   L+    +  ++    S++           H   K
Sbjct: 1475 EARSL----STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEK 1530

Query: 893  ANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRS 952
                 E    +L+  L+E  + +  E    L       +     ++  +   + E     
Sbjct: 1531 VRKQLEVEKLELQSALEEAEASLEHEEGKILR-----AQLEFNQIKAEIERKLAEKDEEM 1585

Query: 953  DMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSF 1012
            +   R++  + DS + S  +ET SR  V                       VK       
Sbjct: 1586 EQAKRNHQRVVDSLQTSLDAETRSRNEVL---------------------RVKKKMEGDL 1624

Query: 1013 NSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVK--DSQSPPIETTGKTCRKLQ 1070
            N    +    + + +  +  + S         I   D+V+  D     I    +    LQ
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ 1684

Query: 1071 NRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQEKMLL 1112
              LE L+ +VE  +   +     +    +R+Q +  Q   L+
Sbjct: 1685 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 151/709 (21%), Positives = 308/709 (43%), Gaps = 80/709 (11%)

Query: 56   KYEVELD----SPRKIIPSPGK-EHFERVLE----EYSHQVKDLQRRLNESNELHEKQKF 106
            ++++ELD    +  +II +    E   R LE    EY  ++++ QR LN+       Q+ 
Sbjct: 1225 EFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTT----QRA 1280

Query: 107  YLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLK 166
             L+    +L  +L+E +     +   +   +Q  EDL+ QL+    E   AK      L+
Sbjct: 1281 KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE----EEGKAKNALAHALQ 1336

Query: 167  DSNTQIEQLRKMMLSHEGVLQEIRSIL--VDFEEASGKKICEHDSMS-TLHFRSLGSAIS 223
             +    + LR+          E++ +L   + E A  +   E D++  T         ++
Sbjct: 1337 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1396

Query: 224  KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELL-------------LQQHQDRIE 270
            + L++ +  +  +  +       LE  K   QN+IE L             L + Q   +
Sbjct: 1397 QRLQDAEEAVEAVNAKC----SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1452

Query: 271  QLISEHEVEITGLTEKASSARSQANSIQSQMEIIQ---EQARNQNSMYMRQLSDLESTVS 327
            ++++E + +      +  S++ +A S+ +++  ++   E++      + R+  +L+  +S
Sbjct: 1453 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1512

Query: 328  QLRSELRE-AKRMYEDKTEELEKQLVLANSELTEARTERD-QFSQESGNL---DDQLQKL 382
             L  +L E  K ++E   E++ KQL +   EL  A  E +     E G +     +  ++
Sbjct: 1513 DLTEQLGEGGKNVHE--LEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI 1570

Query: 383  LADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELD----NRNMEVQRLEALLKAL 438
             A++ ++  E   E EQ KR   R       +D L+  LD    +RN EV R++  ++  
Sbjct: 1571 KAEIERKLAEKDEEMEQAKRNHQR------VVDSLQTSLDAETRSRN-EVLRVKKKMEGD 1623

Query: 439  KSECQGQME--RQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSER 496
             +E + Q+    +MAA     E+ ++V SL + L+ T+  L   V      K  +   ER
Sbjct: 1624 LNEMEIQLSHANRMAA-----EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1678

Query: 497  TISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQ 556
              + L   L+E    +E T          +    + +Q L ++   L N + + E+   Q
Sbjct: 1679 RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQ 1738

Query: 557  M-TEKDKVIEILRQQIEN----------MTQLVGQHGRTAGAMQVEKAQLEKEINDRRME 605
            + +E ++ ++  R   E           M + + +   T+  ++  K  +E+ I D +  
Sbjct: 1739 LQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHR 1798

Query: 606  LKELKILKDKKDAK-IRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQL---LNE 661
            L E + +  K   K +++LEARV +LE E        +E ++ ++  ++   +L     E
Sbjct: 1799 LDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEE 1858

Query: 662  VKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQ 710
             K +   L +L ++ ++  + ++ ++EE E   N    + +  Q EL++
Sbjct: 1859 DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1907



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 129/674 (19%), Positives = 275/674 (40%), Gaps = 77/674 (11%)

Query: 462  KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITK 521
            K+  L    E+ KEM   + EE    K TLE SE    +L   +             ++ 
Sbjct: 837  KIKPLLKSAETEKEMAT-MKEEFGRIKETLEKSEARRKELEEKM-------------VSL 882

Query: 522  LRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQH 581
            L+ + DL+LQ    ++ E D+L + +  C+ L     + +  ++ + +++E+  ++  + 
Sbjct: 883  LQEKNDLQLQ----VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAEL 938

Query: 582  GRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAG 641
                  ++ E ++L+K+I+D  + L +++  K   + K++ L   ++ L+    KL    
Sbjct: 939  TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT--- 995

Query: 642  SERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQL 701
                +  K +++   Q L++++    ++N+LS+    L++   +    +E    K++M L
Sbjct: 996  ----KEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQ-EKKVRMDL 1050

Query: 702  KSAQSELE-QTRNTLKSMEGSDGHAMKVAMGMQKQ---ITAKRGQID-----AL------ 746
            + A+ +LE   + T +S+   +   +++   ++K+   I  +  +I+     AL      
Sbjct: 1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL 1110

Query: 747  ---QSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLK 803
               Q++I+ LEE +      +  +++ +S LS+EL  ++    +  G   V     ++ +
Sbjct: 1111 KENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1170

Query: 804  EKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRL 863
             +   M   L++A+LQ           E  +  L+ +H   + EL G    +   +K +L
Sbjct: 1171 AEFQKMRRDLEEATLQ----------HEATAAALRKKHADSVAEL-GEQIDNLQRVKQKL 1219

Query: 864  LQPASVTRSH-SNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVS 922
             +  S  +    +V S+         +  K +   ED   + +  L+E +  +N+     
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279

Query: 923  LSKTEEDGRTSLGALEDRVRDCITESSLRSDMCH--RSNNSLRDSTEGSKSSETLSREPV 980
                 E+G     A +   ++ +     R  + +  +  +  R   E  K+   L+    
Sbjct: 1280 AKLQTENGEL---ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA---- 1332

Query: 981  TLHA--GDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQ 1038
              HA    R D   C           +  A      S   S V    T     +I  T +
Sbjct: 1333 --HALQSARHD---CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1387

Query: 1039 YRSAKP-----IHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSM 1093
               AK      +  ++   ++ +    +  KT  +LQN +E L   VE       A+   
Sbjct: 1388 LEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1447

Query: 1094 IRNQEKRIQKVKDQ 1107
             RN +K + + K +
Sbjct: 1448 QRNFDKILAEWKQK 1461



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 101/508 (19%), Positives = 224/508 (44%), Gaps = 97/508 (19%)

Query: 74   EHFERVLEEYSHQVKDLQRRLNESNE-LHEKQKFYLRQSV--IDLQTKLQEMQMERDAMA 130
            E F+R  +    ++ DL  +L E  + +HE +K   +  V  ++LQ+ L+E      A A
Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEE------AEA 1551

Query: 131  DIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIR 190
             +   E +    LR QL     E    K   E  L + + ++EQ ++   +H+ V+  ++
Sbjct: 1552 SLEHEEGKI---LRAQL-----EFNQIKAEIERKLAEKDEEMEQAKR---NHQRVVDSLQ 1600

Query: 191  SILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEAL 250
            + L D E  S  ++             +   +   L E++ ++S+        + Q+++L
Sbjct: 1601 TSL-DAETRSRNEVLR-----------VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648

Query: 251  KS---ESQNKIELLLQQHQD---------RIEQLISEHEVEITGLTEKASSARSQANSIQ 298
            +S   ++Q +++  ++ + D         R   L+     E+  + E+   +R  A    
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA---- 1704

Query: 299  SQMEIIQEQAR-----NQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVL 353
             + E+I+   R     +QN+  + Q   +ES ++QL+SE+ EA +   +  E+ +K +  
Sbjct: 1705 -EQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITD 1763

Query: 354  ANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSIT 413
            A     E + E+D  +         L+++  ++ +  K+L    ++ +++          
Sbjct: 1764 AAMMAEELKKEQDTSA--------HLERMKKNMEQTIKDLQHRLDEAEQI---------- 1805

Query: 414  IDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLEST 473
                   L     ++Q+LEA ++ L+ E + + +R   +++G  +S  ++  LT Q E  
Sbjct: 1806 ------ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEED 1859

Query: 474  KEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQEL 533
            K+ L ++ + +   ++ +++ +R          + E A E  N  ++K R        ++
Sbjct: 1860 KKNLLRLQDLVDKLQLKVKAYKR----------QAEEAEEQANTNLSKFR--------KV 1901

Query: 534  QHLKNEGDHLRNVQTECEALKLQMTEKD 561
            QH  +E +   ++  E +  KL+   +D
Sbjct: 1902 QHELDEAEERADI-AESQVNKLRAKSRD 1928


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score =  134 bits (336), Expect = 6e-31
 Identities = 187/871 (21%), Positives = 374/871 (42%), Gaps = 134/871 (15%)

Query: 83  YSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQED 142
           + HQV  + R++ +S             +++DLQ +L+E+Q E D +    R+E   ++ 
Sbjct: 131 HHHQVPSMLRQVRDS-------------TMLDLQAQLKELQRENDLL----RKELDIKDS 173

Query: 143 LRNQLQNTVHELEAAKCLKEDML-KDSNTQIEQLRKMM-LSHE-------------GVLQ 187
                 N++    + +  KE +L K+   ++  L++ M +SHE               L+
Sbjct: 174 KLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELR 233

Query: 188 EIRSILVDFEEASGKKICEHDS--MSTLHFRSLGSAISKILRELDTEISYLKGRIFPVED 245
             R +    ++ SG +  EH +  ++  +FR L +   +  +EL      L+     +E 
Sbjct: 234 TQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIET 293

Query: 246 QLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQ 305
           Q + L +  ++ I+ LL+  Q +   L S+   +    T + + A SQ     S +E+I 
Sbjct: 294 QKQTLNARDES-IKKLLEMLQSK--GLPSKSLEDDNERTRRMAEAESQV----SHLEVIL 346

Query: 306 EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
           +Q   +N                LR EL    ++  +  +    Q V+   +   A  ER
Sbjct: 347 DQKEKEN--------------IHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLER 392

Query: 366 DQFSQESGNLDDQLQKLLA-------DLHKREKELSLEKEQNKRLWDRDTGNSITIDHLR 418
           +       +L+D++Q L A       D  +  K++ + K  +K +          ID L+
Sbjct: 393 N-----IRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFM-------KTKIDQLK 440

Query: 419 RELDNRNMEVQRLEALLKAL---KSECQGQMERQMAAIQGKNESL----EKVSSLTAQLE 471
           +EL  +  E+  L+  L+ L    S+C+  +E    ++  K +       +V +L  +LE
Sbjct: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 500

Query: 472 STKEMLR---KVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDL 528
             +  L    K +++LT +K TL    R + D+   L+ KER I     +I  L+ ++  
Sbjct: 501 EKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDM---LEVKERKINVLQKKIENLQEQLRD 557

Query: 529 KLQELQHLKNEGDHLR----NVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRT 584
           K ++L +LK+    L+    N  T    L+  ++EK+++IE L++Q E            
Sbjct: 558 KDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRE------------ 605

Query: 585 AGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSER 644
               + ++ +LE EI   R E K+LK   +   A++ E E+ + DL+     L +AG +R
Sbjct: 606 ----RDDRERLE-EIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKR 660

Query: 645 LRAVKDIKQERDQLLNEVKTSRSELNNLS--EEYEVLKRNFRNKSEEMEMTTNKLKMQLK 702
              +K ++   +Q   E     ++L      E+   +   F ++ ++++   +  + +  
Sbjct: 661 DSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720

Query: 703 SAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANK 762
            AQ+E+++    LK +E       K           K  ++++L   ++ +++       
Sbjct: 721 KAQAEVDRLLEILKEVENEKNDKDK-----------KIAELESL--TLRHMKDQNKKVAN 767

Query: 763 EKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAE 822
            KH  + EK K +Q L  V   ++ MA   + L+ +E     + T  E  LD    + A 
Sbjct: 768 LKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQE--LDATKARLAS 825

Query: 823 CQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQST 882
            Q  +  +E     L+++    ++E+          +K   L  A+++   +N+   + +
Sbjct: 826 TQQSLAEKEAHLANLRIERRKQLEEI--------LEMKQEALL-AAISEKDANIALLELS 876

Query: 883 ASFLSHHSTKANTLKEDPTRDLKQLLQELRS 913
           AS       +   LK +  R + QL Q+ ++
Sbjct: 877 ASKKKKTQEEVMALKREKDRLVHQLKQQTQN 907



 Score =  112 bits (280), Expect = 2e-24
 Identities = 158/697 (22%), Positives = 285/697 (40%), Gaps = 104/697 (14%)

Query: 72  GKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMAD 131
           G EHF   L E +       RRL   ++   K+ F LR++       L+EM++  +    
Sbjct: 250 GAEHFTIELTEENF------RRLQAEHDRQAKELFLLRKT-------LEEMELRIETQKQ 296

Query: 132 IRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRS 191
                 +S + L   LQ+        K L    L+D N   E+ R+M  +   V      
Sbjct: 297 TLNARDESIKKLLEMLQS--------KGLPSKSLEDDN---ERTRRMAEAESQVSH--LE 343

Query: 192 ILVDFEEASGKKICEHDSMSTLHFRSL-------GSAISKILRELDTEISYLKGRIFPVE 244
           +++D +E     + E      LH RS          A+  ++   DT+I+ L+  I  +E
Sbjct: 344 VILDQKEKENIHLREE-----LHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLE 398

Query: 245 DQLEALKS----------ESQNKIEL------LLQQHQDRIEQLISEHEVEITGLTEKAS 288
           D+++ LK+          E   +IE+       ++   D+++Q +S+ E E+  L  K  
Sbjct: 399 DEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLE 458

Query: 289 SARSQANSIQSQMEIIQEQ--ARNQNSMYM----------------------RQLSDLES 324
           +  +Q +  +  +E+++E   A+ Q +  +                      +QL DL  
Sbjct: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTE 518

Query: 325 TVSQLRSELREAKRMYE----------DKTEELEKQLVLANSELTEARTERDQFSQESGN 374
               L  E+R+ K M E           K E L++QL   + +LT  +        +S N
Sbjct: 519 EKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSN 578

Query: 375 LDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEAL 434
            D  L  L   L ++E+ +   KEQ +R    D      I+  R+E  +   +V  L+A 
Sbjct: 579 TDTALATLEEALSEKERIIERLKEQRER---DDRERLEEIESFRKENKDLKEKVNALQAE 635

Query: 435 LKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS 494
           L   +S      E   +      +   K+ SL   +E  KE   K+  +L  K   +E  
Sbjct: 636 LTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQL-KKAHNIEDD 694

Query: 495 ERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALK 554
            R   +    +++ ++       E  K ++ VD  L+ L+ ++NE +       E E+L 
Sbjct: 695 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 754

Query: 555 LQ-MTEKDKVIEILR--QQIENM--TQLVGQHGRTAGAMQVEKAQLEKE-----INDRRM 604
           L+ M +++K +  L+  QQ+E     QL+ +  R   +M      L+ E     +   R 
Sbjct: 755 LRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQ 814

Query: 605 ELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSE-RLRAVKDIKQERDQLLNEVK 663
           EL   K         + E EA +++L +E+ K +    E +  A+     E+D  +  ++
Sbjct: 815 ELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLE 874

Query: 664 TSRSELNNLSEEYEVLKRNFRNKSEEM-EMTTNKLKM 699
            S S+     EE   LKR       ++ + T N++K+
Sbjct: 875 LSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKL 911



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 160/855 (18%), Positives = 350/855 (40%), Gaps = 164/855 (19%)

Query: 316  MRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNL 375
            +RQ+ D  ST+  L+++L+E +R    + + L K+L + +S+L  +      F       
Sbjct: 139  LRQVRD--STMLDLQAQLKELQR----ENDLLRKELDIKDSKLGSSMNSIKTFWSP---- 188

Query: 376  DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALL 435
                        + +KE  L KE+  R+             L+ ++   + E Q L+  +
Sbjct: 189  ------------ELKKERVLRKEEAARM-----------SVLKEQMRVSHEENQHLQLTI 225

Query: 436  KALKSECQGQME-RQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS 494
            +AL+ E + Q +   +   +  N   E  +     +E T+E  R++  E   +   L   
Sbjct: 226  QALQDELRTQRDLNHLLQQESGNRGAEHFT-----IELTEENFRRLQAEHDRQAKELFLL 280

Query: 495  ERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNV---QTECE 551
             +T+ ++   ++ +++ + A +  I KL   +  K    + L+++ +  R +   +++  
Sbjct: 281  RKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVS 340

Query: 552  ALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI 611
             L++ + +K+K    LR+++   +QL  +  +T                      K L+ 
Sbjct: 341  HLEVILDQKEKENIHLREELHRRSQLQPEPAKT----------------------KALQT 378

Query: 612  LKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNN 671
            + + KD KI  LE  + DLE ++++++ A            ++R++ + +++        
Sbjct: 379  VIEMKDTKIASLERNIRDLE-DEIQMLKANGVLNT------EDREEEIKQIEV------- 424

Query: 672  LSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMG 731
                       +++ S+ M+   ++LK +L   +SEL   +  L+++   +    +    
Sbjct: 425  -----------YKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEV 473

Query: 732  MQKQITAK-------RGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQE------- 777
            +++ +TAK       + ++DAL+ +++  E  +    K+   L EEK  L+ E       
Sbjct: 474  LKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDM 533

Query: 778  LSTVATEKNKMAGELEVLRSQER-------RLKEKVTNMEVALDKASLQFAECQDIIQRQ 830
            L     + N +  ++E L+ Q R        LK++V +++          A  ++ +  +
Sbjct: 534  LEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEK 593

Query: 831  EQESVRLKLQHTLD----IKELQGPGYTSNSSLKPRL-LQPASVTRSHSNVPSSQSTASF 885
            E+   RLK Q   D    ++E++      N  LK ++    A +T   S++   +  AS 
Sbjct: 594  ERIIERLKEQRERDDRERLEEIES-FRKENKDLKEKVNALQAELTEKESSLIDLKEHASS 652

Query: 886  LSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCI 945
            L+    K ++  +     ++Q  +E   +  E         E+D R +     D+++   
Sbjct: 653  LASAGLKRDSKLKSLEIAIEQKKEECSKL--EAQLKKAHNIEDDSRMN-PEFADQIKQLD 709

Query: 946  TESSLRSDMCHRSNNSLR---------DSTEGSKSSETLSREPVTL-HAGDREDPSGCFT 995
             E+S   D C ++   +          ++ +  K  +    E +TL H  D+        
Sbjct: 710  KEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQN------- 762

Query: 996  FTSAASPSVKNSASRSFNSSPKKSPVHSLL--TSSVEGSIGSTSQYRSAKPIHSS----- 1048
                     K  A+   N   +K     LL      E S+   SQ+   + + ++     
Sbjct: 763  ---------KKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTR 813

Query: 1049 ---DSVKDSQSPPIETTGKTCRKLQN-RLESLQTLVEDLQLKNQAMSSMIRNQEKRI--- 1101
               D+ K   +   ++  +    L N R+E  + L E L++K +A+ + I  ++  I   
Sbjct: 814  QELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALL 873

Query: 1102 -----QKVKDQEKML 1111
                 +K K QE+++
Sbjct: 874  ELSASKKKKTQEEVM 888



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 109/558 (19%), Positives = 242/558 (43%), Gaps = 76/558 (13%)

Query: 58  EVELDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNE-SNELHEKQKFYLRQSVIDLQ 116
           E+++     ++ +  +E   + +E Y    K ++ ++++   EL +K+       ++ LQ
Sbjct: 400 EIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKES-----ELLALQ 454

Query: 117 TKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLR 176
           TKL+ +              S    D +  ++     L A    KE       T+++ LR
Sbjct: 455 TKLETL--------------SNQNSDCKQHIEVLKESLTA----KEQRAAILQTEVDALR 496

Query: 177 KMMLSHEGVLQEIRSILVDFEEASGK---KICEHDSMSTLHFRSLGSAISKI------LR 227
             +   E  L +    L D  E  G    +I +   M  +  R +     KI      LR
Sbjct: 497 LRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLR 556

Query: 228 ELDTEISYLKGRIFPVEDQ----------LEALKSESQNKIELLLQQHQ----DRIEQLI 273
           + D +++ LK R+  ++            LE   SE +  IE L +Q +    +R+E++ 
Sbjct: 557 DKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIE 616

Query: 274 SEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLEST-------- 325
           S  + E   L EK ++ +++    +S +  ++E A +  S  +++ S L+S         
Sbjct: 617 SFRK-ENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKK 675

Query: 326 --VSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLL 383
              S+L ++L++A  + +D     E        ++ +   E   +  E G    ++ +LL
Sbjct: 676 EECSKLEAQLKKAHNIEDDSRMNPEFA-----DQIKQLDKEASYYRDECGKAQAEVDRLL 730

Query: 384 ADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQ 443
             L + E E   + +++K++ + +   S+T+ H++ + + +   ++  + L K   ++  
Sbjct: 731 EILKEVENE---KNDKDKKIAELE---SLTLRHMKDQ-NKKVANLKHNQQLEKKKNAQLL 783

Query: 444 GQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTT 503
            ++ R+  ++   ++ L+ +  L   LE T++ L      L + + +L   E  +++L  
Sbjct: 784 EEVRRREDSMADNSQHLQ-IEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLR- 841

Query: 504 SLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKV 563
            ++ +++  E    +   L + +  K   +  L+      +  Q E  ALK    EKD++
Sbjct: 842 -IERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALK---REKDRL 897

Query: 564 IEILRQQIENMTQLVGQH 581
           +  L+QQ +N  +L+  +
Sbjct: 898 VHQLKQQTQNRMKLMADN 915



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 44/208 (21%), Positives = 83/208 (39%), Gaps = 31/208 (14%)

Query: 79  VLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQ-EMQMERDAMADIRRRES 137
           +L+E  ++  D  +++ E   L  +      + V +L+   Q E +     + ++RRRE 
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791

Query: 138 QSQ--------EDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEI 189
                      E+L N L+ T  EL+A K       +    +   L  + +     L+EI
Sbjct: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851

Query: 190 RSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEA 249
             +    +EA    I E D+   L                  E+S  K +    ++++ A
Sbjct: 852 LEMK---QEALLAAISEKDANIAL-----------------LELSASKKK--KTQEEVMA 889

Query: 250 LKSESQNKIELLLQQHQDRIEQLISEHE 277
           LK E    +  L QQ Q+R++ +   ++
Sbjct: 890 LKREKDRLVHQLKQQTQNRMKLMADNYD 917


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score =  133 bits (334), Expect = 1e-30
 Identities = 212/904 (23%), Positives = 380/904 (42%), Gaps = 166/904 (18%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERD----- 127
            KE  + +LE  +     L+     S++LHE +K  L+     L+ KL +M+MERD     
Sbjct: 350  KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKK 404

Query: 128  -----------AMADIR---------------RRESQSQEDLRNQLQNTVHELEAAKCLK 161
                        MA  +                R S+  E  +  L + V+EL +++ LK
Sbjct: 405  IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464

Query: 162  EDMLKDSNTQ-IEQLRKMMLSHEGVLQEIRSILVDFEEASGK-KICEHDSMSTLHFRSLG 219
             +M   S T+ +E+LR  + S EG   +I  +  + +  S K +I E++ +         
Sbjct: 465  LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524

Query: 220  SAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVE 279
              +SK L +   ++          E  +E L+  S+ +I+ +L+Q  + + Q +S     
Sbjct: 525  QNLSKDLMKEKAQL----------EKTIETLRENSERQIK-ILEQENEHLNQTVS----- 568

Query: 280  ITGLTEKAS-SARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKR 338
               L +++  SA ++   I+ + +I+ E  +  +S    +LS +E    Q++ EL   K 
Sbjct: 569  --SLRQRSQISAEARVKDIEKENKILHESIKETSS----KLSKIEFEKRQIKKELEHYKE 622

Query: 339  MYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKE 398
              E + EELE       +EL     E +   ++  NL    +K+ A L +   EL  E  
Sbjct: 623  KGE-RAEELE-------NELHHLEKENELLQKKITNLKITCEKIEA-LEQENSELERENR 673

Query: 399  QNKRLWDRDTGNSITIDHLRRE---LDNRNMEVQRLEALLKALKSECQGQMERQMAAIQG 455
            + K+  D     +  ++ L +E   LD  N+E++R    LK            +MA +Q 
Sbjct: 674  KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC--------ASMKMAQLQL 725

Query: 456  KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEAT 515
            +N+          +LES KE L+K +E L A     E  E +   L    Q  ++ +E +
Sbjct: 726  ENK----------ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775

Query: 516  NAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMT 575
            N +I +L S       ELQ L+ E    + +Q   E LK+      K +E L ++ +++ 
Sbjct: 776  NKKIQQLES-------ELQDLEMEN---QTLQKNLEELKI----SSKRLEQLEKENKSLE 821

Query: 576  QLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKV 635
            Q              E +QLEK+      E K L+   + KD  + E   ++ +LE E  
Sbjct: 822  Q--------------ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867

Query: 636  KL---VNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEM 692
             L   +    E    +K++++E  +L+         L  L E+    K   +  + ++E 
Sbjct: 868  TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 693  TTNKLKMQLKSAQSELEQTRNT----LKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQS 748
             T++L+    + +  L   ++T     K +E       K+   ++K +  K  +I AL++
Sbjct: 928  LTHELEKIGLNKERLLHDEQSTDDSRYKLLES------KLESTLKKSLEIKEEKIAALEA 981

Query: 749  KI-------QFLEEAMTNANKEKHFLK--EEKSKLSQELSTVATEKNKMAGELEVLRSQE 799
            ++       Q L + +    K    LK  +++ ++ Q    ++ E NK   E E   +  
Sbjct: 982  RLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW--ERESQETTR 1039

Query: 800  RRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSL 859
              LK K   +EV  + A+LQ             E   LK Q    +K+L+    T N++L
Sbjct: 1040 ELLKVKDRLIEVERNNATLQ------------AEKQALKTQ----LKQLE----TQNNNL 1079

Query: 860  KPRL--LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINE 917
            + ++  LQ  +V+    N       A     +ST  N+          QLL +  S+ NE
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENST-LNSQSTSLMNQNAQLLIQQSSLENE 1138

Query: 918  EPAV 921
              +V
Sbjct: 1139 NESV 1142



 Score =  130 bits (328), Expect = 5e-30
 Identities = 228/1100 (20%), Positives = 451/1100 (41%), Gaps = 171/1100 (15%)

Query: 77   ERVLEEYSHQVKDLQRRLNESNELH----EKQKFYLRQSVIDLQTKLQEMQMERDAMA-- 130
            E+  E  +  V  L++R   S E      EK+   L +S+ +  +KL +++ E+  +   
Sbjct: 557  EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616

Query: 131  -DIRRRESQSQEDLRNQLQNTVHELEAAK---------CLKEDMLKDSNTQIEQ----LR 176
             +  + + +  E+L N+L +   E E  +         C K + L+  N+++E+    L+
Sbjct: 617  LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676

Query: 177  KMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYL 236
            K + S + +  ++ S+     E    ++ E +     +  SL  A  K + +L  E   L
Sbjct: 677  KTLDSFKNLTFQLESL-----EKENSQLDEENLELRRNVESLKCASMK-MAQLQLENKEL 730

Query: 237  KGRIFPVEDQLEALKSESQNKIELLLQQHQ------DRIEQLISEHEVEITGLTEKASSA 290
            +     ++  LE LK+ S  K E L   +Q       R+++ +     +I  L  +    
Sbjct: 731  ESEKEQLKKGLELLKA-SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789

Query: 291  RSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQ 350
              +  ++Q  +E ++  ++      + QL     ++ Q  S+L + K+  E + + L +Q
Sbjct: 790  EMENQTLQKNLEELKISSKR-----LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844

Query: 351  LVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGN 410
              + ++ L E   +     +E+  L  ++  +  +   R KEL   +++NK L  R T +
Sbjct: 845  AEIKDTTLEENNVKIGNLEKENKTLSKEIG-IYKESCVRLKEL---EKENKELVKRATID 900

Query: 411  SITIDHLRRELDNRNMEVQRLEALLKALKSECQG---QMERQMAAIQGKNESLEKVSSLT 467
              T+  LR +L +  ++ Q++   L+ L  E +      ER +   Q  ++S  K+  L 
Sbjct: 901  IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL--LE 958

Query: 468  AQLEST-KEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRV 526
            ++LEST K+ L    E++ A +  LE S      L   L+  ++     N E  K R   
Sbjct: 959  SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK-----NYEALKQRQDE 1013

Query: 527  DLKLQELQHLKNEGD--HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRT 584
            +  +Q    +  E +     + +T  E LK+    KD++IE+ R       +        
Sbjct: 1014 ERMVQSSPPISGEDNKWERESQETTRELLKV----KDRLIEVERNNATLQAE-------- 1061

Query: 585  AGAMQVEKAQLEKEINDRRMELKELK---ILKDKKDAKIRELEARV----SDLELEKVKL 637
              A++ +  QLE + N+ + ++  L+   +   +++  ++   A++    S L  +   L
Sbjct: 1062 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1121

Query: 638  VNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKL 697
            +N  ++ L     ++ E + ++ E +  +S  ++L +++E L+     ++ E E   +K 
Sbjct: 1122 MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK- 1180

Query: 698  KMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAM 757
               LKSA   LE     L+                  Q+  ++GQ++ L+  ++  +E M
Sbjct: 1181 HGTLKSAHKNLEVEHRDLEDR--------------YNQLLKQKGQLEDLEKMLKVEQEKM 1226

Query: 758  TNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKAS 817
               NK    +  E  KL  E   +    +++  E EVL++  + LK  + N ++   +  
Sbjct: 1227 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1286

Query: 818  LQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRL--LQPASVTRSHSN 875
             +F++ ++  Q+ +  S +L  Q  L + +L+G     N  L  ++  L   + T    N
Sbjct: 1287 AEFSKLKEQYQQLDITSTKLNNQCEL-LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345

Query: 876  VPSSQSTASFLSHHSTKANTLKE----------------DP----------TRDLKQLLQ 909
            + S          +  K N L+                 DP          T  +++L++
Sbjct: 1346 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIK 1405

Query: 910  ELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRD-STEG 968
              +  IN E   SL+ T     +S G L+   +D    SS+ S       NSL D  T G
Sbjct: 1406 SKKD-INRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGS-------NSLEDGQTLG 1457

Query: 969  SKSSETLS-------------------REPVTLHAGDREDPSGCFTFTSAA--------- 1000
            +K S T++                     P  +  G R    G   F++ A         
Sbjct: 1458 TKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSS 1517

Query: 1001 -----SPSVKNSASRSF---------NSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIH 1046
                    V N  + SF         + S   S VH+   +S++    STS   +   +H
Sbjct: 1518 AGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLH 1577

Query: 1047 --SSDSVKDSQSPPIETTGK 1064
               + +V +   P   ++G+
Sbjct: 1578 EVKAGAVNNQSRPQSHSSGE 1597



 Score =  118 bits (295), Expect = 4e-26
 Identities = 216/951 (22%), Positives = 398/951 (41%), Gaps = 166/951 (17%)

Query: 232  EISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISE---HEVEITGLTEKAS 288
            E+++ +  +F +  Q   +   SQ  IE LL+     +++LI E   H   I  L+E+  
Sbjct: 162  EVTHNQENVFDL--QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERD 219

Query: 289  S------ARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED 342
                   A S A S      + + ++R   S+   +L+D ++ + +LR EL E      D
Sbjct: 220  GLHFLPHASSSAQSPCGSPGMKRTESRQHLSV---ELADAKAKIRRLRQELEEKTEQLLD 276

Query: 343  KTEELE------KQLVLAN----SELTEARTERDQFSQESGNLDDQLQKLLADLHKREKE 392
              +ELE      K+L   N    S+   AR  RD+         D L++    + K E E
Sbjct: 277  CKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL--------DALREKAVRVDKLESE 328

Query: 393  LSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAA 452
            +S  KE   RL D        I+  +  ++    + Q L      L+ + +G   R    
Sbjct: 329  VSRYKE---RLHD--------IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377

Query: 453  IQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISD----LTTSLQEK 508
             + + E+L+  + L   +E  ++M RK +EEL  + MTLE +++   D    L   L++ 
Sbjct: 378  HELEKENLQLKAKL-HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436

Query: 509  ERAIEATNA-------EITKLRSRVDLKLQ-ELQHLKNEGDHLRNV--QTECEALKLQMT 558
             R  E + A       E+ +L S   LKL+ E Q L    + LR      E  A K+   
Sbjct: 437  SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKM 496

Query: 559  EKD-----KVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIND-RRMELKELKIL 612
            EK+     K +EIL  +I    Q +      +  +  EKAQLEK I   R    +++KIL
Sbjct: 497  EKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556

Query: 613  KDKKD------AKIRE-----LEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
            + + +      + +R+      EARV D+E E   L  +  E    +  I+ E+ Q+  E
Sbjct: 557  EQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616

Query: 662  VKTSR----------SELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQT 711
            ++  +          +EL++L +E E+L++   N    +++T  K++  L+   SELE+ 
Sbjct: 617  LEHYKEKGERAEELENELHHLEKENELLQKKITN----LKITCEKIE-ALEQENSELERE 671

Query: 712  RNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEK 771
               LK             +   K +T    Q+++L+ +   L+E      +    LK   
Sbjct: 672  NRKLKK-----------TLDSFKNLTF---QLESLEKENSQLDEENLELRRNVESLKCAS 717

Query: 772  SKLSQ---ELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQ 828
             K++Q   E   + +EK ++   LE+L++  +    K   +EV+     ++    Q  ++
Sbjct: 718  MKMAQLQLENKELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLE 773

Query: 829  RQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSH 888
               ++  +L+     ++++L+    T   +L+   +    + +      S +   S L  
Sbjct: 774  NSNKKIQQLE----SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE- 828

Query: 889  HSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITES 948
                         +D KQL +E + +   + A     T E+    +G LE   +    E 
Sbjct: 829  -------------KDKKQLEKENKRL--RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873

Query: 949  SLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSA 1008
             +  + C R     +++ E  K +    +  VTL    RED           S  +K   
Sbjct: 874  GIYKESCVRLKELEKENKELVKRATIDIKTLVTL----RED---------LVSEKLK--- 917

Query: 1009 SRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIE-----TTG 1063
            ++  N+  +K      LT  +E  IG   +    + +H   S  DS+   +E     T  
Sbjct: 918  TQQMNNDLEK------LTHELE-KIGLNKE----RLLHDEQSTDDSRYKLLESKLESTLK 966

Query: 1064 KTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVK---DQEKML 1111
            K+    + ++ +L+  +E+    NQ +   ++  +K  + +K   D+E+M+
Sbjct: 967  KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1017



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 151/809 (18%), Positives = 332/809 (41%), Gaps = 141/809 (17%)

Query: 341  EDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLAD-----LHKREKELSL 395
            E  TEE++K L+L      + + ++++F +    LD   +  +A       H +E    L
Sbjct: 115  EQGTEEVKKLLLLLLGCAVQCQ-KKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173

Query: 396  EKEQNKRLWDRDTGNSIT--IDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAI 453
            +  +   +   D    +     HL+R +D R+   +  E +++ L  E  G      A+ 
Sbjct: 174  QWMEVTDMSQEDIEPLLKNMALHLKRLIDERD---EHSETIIE-LSEERDGLHFLPHASS 229

Query: 454  QGKN-------ESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ 506
              ++       +  E    L+ +L   K  +R++ +EL  K              T  L 
Sbjct: 230  SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEK--------------TEQLL 275

Query: 507  EKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEI 566
            + ++ +E    E+ +L+       QE  +L ++    R  + E +AL+ +    DK+   
Sbjct: 276  DCKQELEQMEIELKRLQ-------QENMNLLSDARSARMYRDELDALREKAVRVDKLESE 328

Query: 567  LRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDA------KI 620
            + +  E +  +           +  KA++E+   D ++ L+   +L+D+ +       K+
Sbjct: 329  VSRYKERLHDI-----------EFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377

Query: 621  RELE-------ARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLS 673
             ELE       A++ D+E+E+        E +     ++  + Q ++E      EL  +S
Sbjct: 378  HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437

Query: 674  EEYEVLKRNFRNKSEEMEMTTN----KLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVA 729
               E+ +   ++   E+   T+    KL+M+ +S    +E+ R T+ S+EG+    +K  
Sbjct: 438  RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK-- 495

Query: 730  MGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMA 789
              M+K+      +++ L+++I   ++++ N       L +EK++L +   T+ T +    
Sbjct: 496  --MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK---TIETLRENSE 550

Query: 790  GELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQ 849
             ++++L  +   L + V+    +L + S   AE +  ++  E+E+   K+ H   IKE  
Sbjct: 551  RQIKILEQENEHLNQTVS----SLRQRSQISAEAR--VKDIEKEN---KILHE-SIKE-- 598

Query: 850  GPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLS---HHSTKANTLKEDPTRDLKQ 906
                 ++S L     +   + +   +       A  L    HH  K N L +    +LK 
Sbjct: 599  -----TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653

Query: 907  LLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSL-RDS 965
              +++ ++  E      S+ E + R     L     D     + + +   + N+ L  ++
Sbjct: 654  TCEKIEALEQEN-----SELERENRKLKKTL-----DSFKNLTFQLESLEKENSQLDEEN 703

Query: 966  TEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLL 1025
             E  ++ E+L    + +                 A   ++N    S     KK     LL
Sbjct: 704  LELRRNVESLKCASMKM-----------------AQLQLENKELESEKEQLKKG--LELL 744

Query: 1026 TSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQL 1085
             +S          ++  + +  S    D ++  ++   KT      +++ L++ ++DL++
Sbjct: 745  KAS----------FKKTERLEVSYQGLDIENQRLQ---KTLENSNKKIQQLESELQDLEM 791

Query: 1086 KNQAMSSMIRN---QEKRIQKVKDQEKML 1111
            +NQ +   +       KR+++++ + K L
Sbjct: 792  ENQTLQKNLEELKISSKRLEQLEKENKSL 820


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  131 bits (330), Expect = 3e-30
 Identities = 176/885 (19%), Positives = 376/885 (42%), Gaps = 142/885 (16%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADI 132
            K+  E  L++   ++  LQ ++++  ++H  Q    ++ + +LQ +++E++ E +A   +
Sbjct: 1077 KQQIEEKLKKKEFELSQLQAKIDDE-QVHSLQ---FQKKIKELQARIEELEEEIEAEHTL 1132

Query: 133  RRRESQSQEDLRNQLQNTVHELEAAK---CLKEDMLKDSNTQIEQLRKMM----LSHEGV 185
            R +  + + DL  +L+     LE A      + +M K    + +++R+ +    L HE  
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192

Query: 186  LQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVED 245
               +R    D     G++I                 + ++ ++L+ E S LK  I  +  
Sbjct: 1193 AATLRKKQADSVAELGEQI---------------DNLQRVKQKLEKEKSELKMEIDDMAS 1237

Query: 246  QLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQ 305
             +EAL S+S++ IE   +  +D+  ++ ++ E +    T+       Q   +Q+Q   + 
Sbjct: 1238 NIEAL-SKSKSNIERTCRTVEDQFSEIKAKDEQQ----TQLIHDLNMQKARLQTQNGELS 1292

Query: 306  EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
             +   + S+    +S L  +   L  +L E KR  E++T+          S   +    R
Sbjct: 1293 HRVEEKESL----ISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLR 1348

Query: 366  DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRN 425
            +Q+ +E        Q+  A+L +   + + E  Q +  ++ D                  
Sbjct: 1349 EQYEEE--------QEAKAELQRALSKANSEVAQWRTKYETDA----------------- 1383

Query: 426  MEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELT 485
              +QR E L +A K   Q         +Q   E+ E  +S  A LE TK+ L+  VE+L 
Sbjct: 1384 --IQRTEELEEAKKKLAQ--------RLQEAEENTETANSKCASLEKTKQRLQGEVEDLM 1433

Query: 486  AKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRN 545
                 LE S    + L    +  ++ +     ++ + ++ ++   +E + L  E   +RN
Sbjct: 1434 RD---LERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRN 1490

Query: 546  VQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRME 605
               E       +  ++K    L+++I ++T+ + + G+     +  K  +E+E +D ++ 
Sbjct: 1491 AYEEVVDQLETLRRENKN---LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVA 1547

Query: 606  LKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTS 665
            L+E++   + +++KI  ++     LEL +VK     SE  R V +  +E +QL    + +
Sbjct: 1548 LEEVEGSLEHEESKILRVQ-----LELSQVK-----SELDRKVIEKDEEIEQLKRNSQRA 1597

Query: 666  RSELNNLSEEYEVLKRNFRNK-SEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGH 724
               L ++ +  E+  RN   +  ++ME   N++++QL  +  ++ +T+  L++++G    
Sbjct: 1598 AEALQSVLDA-EIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG---- 1652

Query: 725  AMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATE 784
                      Q+   +  +D      + L+E +    +    L EE  ++   L    TE
Sbjct: 1653 ----------QLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALE--QTE 1700

Query: 785  KNKMAGELEVLRSQER--RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHT 842
            + +   E E+L + +R   L  + T++     K     A+CQ  ++   QES        
Sbjct: 1701 RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQES-------- 1752

Query: 843  LDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTR 902
                        +    K  +   A +      +   Q T++ L           E   +
Sbjct: 1753 ----------RNAEEKAKKAITDAAMMA---EELKKEQDTSAHL-----------ERMKK 1788

Query: 903  DLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITE 947
            +L+Q +++L+  ++E   ++L    + G+  +  LE+RVR+   E
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLAL----KGGKKQIQKLENRVRELENE 1829



 Score =  117 bits (292), Expect = 8e-26
 Identities = 186/1053 (17%), Positives = 432/1053 (41%), Gaps = 133/1053 (12%)

Query: 114  DLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIE 173
            ++ T  ++ +  ++ +A    R  + +E + + LQ   ++L+     + + L D+  + E
Sbjct: 852  EMATMKEDFERTKEELARSEARRKELEEKMVSLLQEK-NDLQLQVQSETENLMDAEERCE 910

Query: 174  QLRKMMLSHEGVLQEIRSILVDFEEASGKKICE----HDSMSTLH--FRSLGSAISKILR 227
             L K  +  E  ++E+   L + EE + + + +     D  S+L      L   ++K+ +
Sbjct: 911  GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEK 970

Query: 228  E---LDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGL- 283
            E    + ++  L   +  +E+ +  L  E ++    L + HQ  ++ L  E + ++ GL 
Sbjct: 971  EKHATENKVKNLSEEMTALEENISKLTKEKKS----LQEAHQQTLDDLQVEED-KVNGLI 1025

Query: 284  ---------TEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELR 334
                     T+    +  Q   +++ +E  + +      M    + DLE+   Q+  +L+
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085

Query: 335  EAK-----------------RMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDD 377
            + +                   ++ K +EL+ ++     E+    T R +  ++  +L  
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLAR 1145

Query: 378  QLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKA 437
            +L+++   L +     S + E NK+              +RR+L+   ++ +   A L+ 
Sbjct: 1146 ELEEISERLEEASGATSAQIEMNKK-------REAEFQKMRRDLEEATLQHEATAATLRK 1198

Query: 438  LKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT 497
             +++   ++  Q+  +Q   + LEK  S   +L+   + +   +E L+  K  +E + RT
Sbjct: 1199 KQADSVAELGEQIDNLQRVKQKLEKEKS---ELKMEIDDMASNIEALSKSKSNIERTCRT 1255

Query: 498  ISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQM 557
            + D  + ++ K+        ++   ++R+  +  EL H   E + L             +
Sbjct: 1256 VEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL-------------I 1302

Query: 558  TEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKD 617
            ++  K  + L QQ+E + + + +  +   AM      L+   +D  +  ++ +  ++ K 
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMA---HALQSSRHDCDLLREQYEEEQEAKA 1359

Query: 618  AKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYE 677
               R L    S++   + K      +R   +++ K++  Q L E + +    N+      
Sbjct: 1360 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANS------ 1413

Query: 678  VLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQIT 737
                    K   +E T  +L+ +++    +LE++     +++    +  KV    ++++ 
Sbjct: 1414 --------KCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD 1465

Query: 738  AKRGQIDALQSKIQFLEEA---MTNANKEK----HFLKEEKSKLSQELSTVATEKNKMAG 790
              + +++A Q + + L      M NA +E       L+ E   L +E+S +  +  +   
Sbjct: 1466 ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525

Query: 791  ELEVLRSQERRLKEKVTNMEVALD--KASLQFAECQDIIQRQEQESVRLKLQHTLDIKEL 848
             L+     ++ ++++ ++++VAL+  + SL+  E + +  + E   V+ +L   +  K+ 
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585

Query: 849  QGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLL 908
            +      NS      LQ        S                  A  LK+    DL ++ 
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSR---------------NDALRLKKKMEGDLNEME 1630

Query: 909  QELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRD---- 964
             +L     +     +++T++  RT  G L+D        S L  D   RSN  L++    
Sbjct: 1631 IQLGHSNRQ-----MAETQKHLRTVQGQLKD--------SQLHLDDALRSNEDLKEQLAI 1677

Query: 965  -STEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAAS-PSVKNSASRSFNSSPKKSPVH 1022
                     E L    V L   +R           A+    + +S + S  ++ KK    
Sbjct: 1678 VERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEAD 1737

Query: 1023 -SLLTSSVEGSI--GSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTL 1079
             +   + VE SI     ++ ++ K I  +  + +     ++    T   L+   ++L+  
Sbjct: 1738 IAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNLEQT 1793

Query: 1080 VEDLQLK-NQAMSSMIRNQEKRIQKVKDQEKML 1111
            V+DLQ + ++A    ++  +K+IQK++++ + L
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVREL 1826



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 136/666 (20%), Positives = 290/666 (43%), Gaps = 108/666 (16%)

Query: 84   SHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDL 143
            + Q+++L+R++ E  +        L+ S  D     ++ + E++A A+++R  S++  ++
Sbjct: 1313 TQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372

Query: 144  R--------NQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQ----EIRS 191
                     + +Q T  ELE AK      L+++    E       S E   Q    E+  
Sbjct: 1373 AQWRTKYETDAIQRT-EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED 1431

Query: 192  ILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALK 251
            ++ D E +       H + +TL          K  R  D  ++  K ++   + +LEA +
Sbjct: 1432 LMRDLERS-------HTACATL---------DKKQRNFDKVLAEWKQKLDESQAELEAAQ 1475

Query: 252  SESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQ 311
             ES++ +   L + ++  E+++ + E           + R +  ++Q ++  + EQ   +
Sbjct: 1476 KESRS-LSTELFKMRNAYEEVVDQLE-----------TLRRENKNLQEEISDLTEQIA-E 1522

Query: 312  NSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERD----- 366
                +++    +  V Q +S+L+ A    E   E  E +++    EL++ ++E D     
Sbjct: 1523 TGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE 1582

Query: 367  ------QFSQESGNLDDQLQKLL-ADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRR 419
                  Q  + S    + LQ +L A++  R   L L+K+    L + +    I + H  R
Sbjct: 1583 KDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEME----IQLGHSNR 1638

Query: 420  ELDNRNMEVQRLEALLK--------ALKSECQGQMERQMAAIQGKNESL-EKVSSLTAQL 470
            ++      ++ ++  LK        AL+S     ++ Q+A ++ +N  L E++  +   L
Sbjct: 1639 QMAETQKHLRTVQGQLKDSQLHLDDALRSN--EDLKEQLAIVERRNGLLLEELEEMKVAL 1696

Query: 471  ESTKEMLRKVVEELTAKKMTLESSERT--ISDLTTSLQEKERAIEATNAEITKLRSRVDL 528
            E T+   R   +EL      L++S+R   +    TSL   ++ +EA   +I + ++ V+ 
Sbjct: 1697 EQTERTRRLSEQEL------LDASDRVQLLHSQNTSLINTKKKLEA---DIAQCQAEVEN 1747

Query: 529  KLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAM 588
             +QE ++ +             E  K  +T+   + E L+++ +           T+  +
Sbjct: 1748 SIQESRNAE-------------EKAKKAITDAAMMAEELKKEQD-----------TSAHL 1783

Query: 589  QVEKAQLEKEINDRRMELKELKILKDKKDAK-IRELEARVSDLELEKVKLVNAGSERLRA 647
            +  K  LE+ + D +  L E + L  K   K I++LE RV +LE E       G+E L+ 
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843

Query: 648  VKDIKQERDQLLNEVKTSRS---ELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSA 704
                +++  ++  + +        L +L ++ +   ++++ ++EE E   N    + +  
Sbjct: 1844 AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903

Query: 705  QSELEQ 710
            Q ELE+
Sbjct: 1904 QHELEE 1909



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 36/123 (29%), Positives = 65/123 (52%), Gaps = 20/123 (16%)

Query: 75   HFERVLEEYSHQVKDLQRRLNESNEL----HEKQKFYLRQSVIDLQTKLQEMQMERDAMA 130
            H ER+ +     VKDLQ RL+E+ +L     +KQ   L   V +L+ +L +++ +R A A
Sbjct: 1782 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL-DVEQKRGAEA 1840

Query: 131  ---------DIRRRESQSQEDLRN--QLQNTVHELEAA----KCLKEDMLKDSNTQIEQL 175
                      ++    Q++ED +N  +LQ+ V +L+A     K   E+  + +NTQ+ + 
Sbjct: 1841 LKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRC 1900

Query: 176  RKM 178
            R++
Sbjct: 1901 RRV 1903


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  131 bits (330), Expect = 3e-30
 Identities = 214/1100 (19%), Positives = 449/1100 (40%), Gaps = 141/1100 (12%)

Query: 79   VLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQ 138
            +L E   Q+K LQ  ++     + K         I+   ++++   + + +A   +RES 
Sbjct: 583  LLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESA 642

Query: 139  SQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEE 198
                   +L+  + EL       E+ ++   +Q+E  +KM +  E  LQ   + +     
Sbjct: 643  FLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTS 702

Query: 199  ASGKKICEHDSMSTLHFRSLGSAISKILRELDTEIS---------YLKGRIFPVEDQLEA 249
                K+   D +  L    L   I+ + +EL+ E+           L   +  +  ++E 
Sbjct: 703  LIDGKV-PKDLLCNL---ELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVER 758

Query: 250  LKSESQNKIELL--LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQ 307
            L+ E Q+K E L  +   +D++   +   E  + GL E+    +    + QS  +   ++
Sbjct: 759  LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE 818

Query: 308  ARNQNSMYM-----------------RQLSDLESTVSQLRSELREAKRMYEDKTEELEKQ 350
             +N  +++M                 +++ +L     +  S L   K     KT+EL+++
Sbjct: 819  FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEK 878

Query: 351  LVLANSELTEARTERDQFSQESGNLDDQLQKL----------LADLHKREKELSLEKEQN 400
                  E+ E   E +Q  ++  N D  LQ +          L    +  K L+ EK+  
Sbjct: 879  ----TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934

Query: 401  KRLW-----DRDTGNSITIDHLRRELDNRNMEVQRLEAL------LKALKSECQGQMERQ 449
            K+L      +RD   S   D +   +D +      LE+L      +  LKS+   ++ R 
Sbjct: 935  KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994

Query: 450  MAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTA--KKMTLESSERTISDLTTSLQE 507
            +   +   E+ ++       ++  +++  K  + LTA  K   +   +R I  L     E
Sbjct: 995  LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054

Query: 508  KERAIEATNAE----ITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKV 563
             ++ +E+  AE     T L+  +++ ++  + L+  GD L+  Q                
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ---------------- 1098

Query: 564  IEILRQQIENMTQLVGQHGRTAGAM-QVEKAQLEK--EINDRRMELKELKILKDKKDAKI 620
             EI+ Q+  +  +  G+  RT   + +VE+   EK  ++ +++ +L  ++    +   KI
Sbjct: 1099 -EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157

Query: 621  RELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLK 680
             E+E   ++L+ +++ L +  +ERL   + + +  ++ +  +   R  L  L + +E  +
Sbjct: 1158 NEIENLKNELKNKELTLEHMETERLELAQKLNENYEE-VKSITKERKVLKELQKSFETER 1216

Query: 681  RNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR 740
             + R    E+E T  + K +LK A   L++ + T+                +++ ++ K 
Sbjct: 1217 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE--------------LRRSVSEKT 1262

Query: 741  GQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
             QI       Q LE++ T   +E   L EE+  L        +E  +   ELE+L +++ 
Sbjct: 1263 AQI----INTQDLEKSHTKLQEEIPVLHEEQELLPNVKE--VSETQETMNELELL-TEQS 1315

Query: 801  RLKEKVTNMEVALDKASL--QFAECQDIIQRQEQESVRLK-LQHTLDIKELQGPGYTSNS 857
              K+  T   + +++  L  +F E Q+ I+   +E   LK ++  L++K  Q   +   +
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375

Query: 858  SLKPRLLQPASVTRSHSNVPSSQST--ASFLSHHSTKANTLKE------DPTRDLKQLLQ 909
              K +  Q       +     +++T   S +     K + L          ++ L++   
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435

Query: 910  ELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGS 969
            E++SV  E+    L + +E  ++    L++ +++ + +     +    ++  L++     
Sbjct: 1436 EMKSVAKEKD--DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE----- 1488

Query: 970  KSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSV 1029
               ET++   V L   + E  S       A +  ++N     +    K+   +    S V
Sbjct: 1489 -QEETINELRVNLSEKETE-ISTIQKQLEAINDKLQNKIQEIYE---KEEQFNIKQISEV 1543

Query: 1030 EGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQA 1089
            +  +    Q++  +        KDS    IE+      +L NRL+  Q   E++Q+  + 
Sbjct: 1544 QEKVNELKQFKEHR------KAKDSALQSIES---KMLELTNRLQESQ---EEIQIMIKE 1591

Query: 1090 MSSMIRNQEKRIQKVKDQEK 1109
               M R QE  +Q  +DQ K
Sbjct: 1592 KEEMKRVQE-ALQIERDQLK 1610



 Score =  131 bits (330), Expect = 3e-30
 Identities = 202/1037 (19%), Positives = 442/1037 (42%), Gaps = 110/1037 (10%)

Query: 96   ESNELHEKQK--FYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHE 153
            + NE+ E+Q+  F L Q   +LQ  L+ +  E++          Q + DL+  ++ T+  
Sbjct: 1034 KDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE----------QLKTDLKENIEMTIEN 1083

Query: 154  LEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTL 213
             E  + L +++ K     + Q +   +  EG L      L + EE   +K  +       
Sbjct: 1084 QEELRLLGDELKKQQEI-VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ-- 1140

Query: 214  HFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIE--Q 271
                      + L  +  E+S ++ +I    +++E LK+E +NK   L     +R+E  Q
Sbjct: 1141 ----------QQLLNVQEEMSEMQKKI----NEIENLKNELKNKELTLEHMETERLELAQ 1186

Query: 272  LISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRS 331
             ++E+  E+  +T++    +    S +++ + ++   R   +  ++   +L+     L+ 
Sbjct: 1187 KLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKE 1246

Query: 332  E---LREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHK 388
                + E +R   +KT ++     L  S  T+ + E     +E   L +   K +++  +
Sbjct: 1247 HQETIDELRRSVSEKTAQIINTQDLEKSH-TKLQEEIPVLHEEQELLPNV--KEVSETQE 1303

Query: 389  REKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMER 448
               EL L  EQ+       T +S T+  +  E    N + Q  +  +K+L  E +  ++ 
Sbjct: 1304 TMNELELLTEQST------TKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE-RDNLKT 1356

Query: 449  QMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQE- 507
               A++ K++ L+         E  +E L K+ E  + ++ +L   E+  ++ T  + E 
Sbjct: 1357 IKEALEVKHDQLK---------EHIRETLAKIQESQSKQEQSLNMKEKD-NETTKIVSEM 1406

Query: 508  -----KERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDK 562
                 K+ A+     E+  L  R+     E++ +  E D L+ +Q   ++   Q+  K+ 
Sbjct: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQL--KEN 1464

Query: 563  VIEILRQQIENMTQLVGQH------GRTAGAMQVEKAQLEKEINDRRMELKELKILKDKK 616
            + EI+ + +E   +L   H        T   ++V  ++ E EI+  +   K+L+ + DK 
Sbjct: 1465 IKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ---KQLEAINDKL 1521

Query: 617  DAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSEL-NNLSEE 675
              KI+E+  +     ++++  V      L+  K+ ++ +D  L  +++   EL N L E 
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQES 1581

Query: 676  YEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQ 735
             E ++   + K EEM+     L+++    +   ++    +K  +  +   +K+    + Q
Sbjct: 1582 QEEIQIMIKEK-EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQ 1640

Query: 736  ITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVL 795
               K  +I+ L+ + +  +  + N   E   L +   +  +E+ +V  E++ +    E L
Sbjct: 1641 --EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETL 1698

Query: 796  RSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESV----RLKLQHTLDIKELQGP 851
            + +  +LKE +    +  D    +  +   +  ++ QE++     +  + T +I  +Q  
Sbjct: 1699 KVERDQLKENLRE-TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKD 1757

Query: 852  GYTSNSSLKPRLLQPASVTR-SHSNVPSSQST----ASFLSHHSTKANTLKED---PTRD 903
               SN +LK + L+     R +H ++   Q T       +S  + K + +++D       
Sbjct: 1758 LEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAK 1817

Query: 904  LKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALED---RVRD-CITESSLRSD---MCH 956
            L++ +QEL++  NE   ++L K   + +  +  +E    +++D  +T S L  +   +  
Sbjct: 1818 LQEKIQELKA--NEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQ 1875

Query: 957  RSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSP 1016
            + + +L +     K  + L R   TL   +R+        T A    ++     +     
Sbjct: 1876 KLHENLEEMKSVMKERDNLRRVEETLKL-ERDQLKESLQETKARDLEIQQELKTA----- 1929

Query: 1017 KKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESL 1076
                   +L+   + ++    +  S K I  SD  KD      E   K  ++LQ +   L
Sbjct: 1930 ------RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ-KKIQELQKKELQL 1982

Query: 1077 QTLVEDLQLKNQAMSSM 1093
              + ED+ + ++ ++ M
Sbjct: 1983 LRVKEDVNMSHKKINEM 1999



 Score =  120 bits (300), Expect = 9e-27
 Identities = 187/927 (20%), Positives = 406/927 (43%), Gaps = 125/927 (13%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKL-QEMQM--ERDAMADIRRRES 137
            E+   + ++++ +L E N+L E +        ++ +TK  QEMQ+  E   + ++ +   
Sbjct: 515  EQLRTEKEEMELKLKEKNDLDEFE-------ALERKTKKDQEMQLIHEISNLKNLVKHAE 567

Query: 138  QSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSH--EGVLQEIRSILVD 195
               +DL N+L + V           ++L++   QI++L++ + S   E +  ++   L  
Sbjct: 568  VYNQDLENELSSKV-----------ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLES 616

Query: 196  FEEASGKKICEHDSMS--------TLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQL 247
             E+    K    D+ +        +   RS    + + ++EL T    ++  I   + QL
Sbjct: 617  IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQL 676

Query: 248  EALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQM--EIIQ 305
            EA K + Q  +E  LQ   + I +L S  + ++            +   +Q ++  E+ +
Sbjct: 677  EA-KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEE 735

Query: 306  EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTER 365
             +A  +  + + +L  L S V +LR E+       +DK+EEL               +E+
Sbjct: 736  NEALREEVILLSELKSLPSEVERLRKEI-------QDKSEELHI-----------ITSEK 777

Query: 366  DQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITI----------- 414
            D+   E  + + ++Q LL ++ K + +L+   + N +  D++  N  T+           
Sbjct: 778  DKLFSEVVHKESRVQGLLEEIGKTKDDLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMV 836

Query: 415  ----DHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQL 470
                + + +E+ N + E Q+ ++ L ALK+E   + +      +   E L ++  L  QL
Sbjct: 837  LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL 896

Query: 471  ESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKE---RAIEATNAEITKLRS--- 524
            E+    L+ V  E   K +  E  ++T+ ++ T  QEK+   +  E+   E  +L+S   
Sbjct: 897  ENRDSTLQTVERE---KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953

Query: 525  -RVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGR 583
              V++ +   + L+N  + L+  Q     LK +++E          ++     +    G 
Sbjct: 954  DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISE----------EVSRNLHMEENTGE 1003

Query: 584  TAGAMQVEKAQLEKEINDRRMELKELKIL-KDKKDAKIRELEARVSDLELEKVKL----- 637
            T    Q +   ++K+   + +E K  + L  D KD +I E + ++  L  EK +L     
Sbjct: 1004 TKDEFQQKMVGIDKK---QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1060

Query: 638  -VNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVL---KRNFRNKSEEMEMT 693
             V A  E+L+   D+K+  +  +   +  R   + L ++ E++   K +   K  E+  T
Sbjct: 1061 SVIAEKEQLKT--DLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118

Query: 694  TNKL---KMQLKSAQSELEQTRNTLKSMEGSDGHAMK---VAMGMQKQITAKRGQIDALQ 747
             ++L   + +LK    +L++ +  L +++       K       ++ ++  K   ++ ++
Sbjct: 1119 CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHME 1178

Query: 748  SKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVT 807
            ++   L + +    +E   + +E+  L +   +  TE++ + G +  + +   + KE+  
Sbjct: 1179 TERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEE-- 1236

Query: 808  NMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPA 867
                 L  A +   E Q+ I  + + SV  K    ++ ++L+   +T      P L +  
Sbjct: 1237 -----LKIAHIHLKEHQETID-ELRRSVSEKTAQIINTQDLE-KSHTKLQEEIPVLHEEQ 1289

Query: 868  SVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTR---DLKQLLQELRSVINEEPAVSLS 924
             +  +   V  +Q T + L    T+ +T K+  T    ++++L    +   ++E   SL+
Sbjct: 1290 ELLPNVKEVSETQETMNEL-ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLT 1348

Query: 925  KTEEDGRTSLGALE---DRVRDCITES 948
            K  ++ +T   ALE   D++++ I E+
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRET 1375



 Score =  105 bits (263), Expect = 2e-22
 Identities = 223/1126 (19%), Positives = 466/1126 (41%), Gaps = 168/1126 (14%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNEL--HEKQKFYLRQSV----IDLQTKLQEMQMER 126
            +E +E+  +    Q+ ++Q ++NE  +   H K K    QS+    ++L  +LQE Q E 
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585

Query: 127  DAMADIRRRESQSQEDL---RNQLQNTVHELEAAKCLKEDMLKDSN----TQIEQLRKMM 179
              M   +    + QE L   R+QL+    E+ A   +KE   K+      T + + ++ M
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK--MKESQEKEYQFLKMTAVNETQEKM 1643

Query: 180  LSHEGVLQEIRSILVDFEEASGKKI----CEHDSMSTLHFRSLGSA---ISKILRELDTE 232
               E + ++  +  ++ E    + I      H+++  +  RS+      +  +   L  E
Sbjct: 1644 CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM--RSVTKERDDLRSVEETLKVE 1701

Query: 233  ISYLKGRIFP-VEDQLEALKSESQNKIELLLQQHQDRIEQL---ISEHEVEITGLTEKAS 288
               LK  +   +   LE  K E    + + L++HQ+ I++L   +SE   EI+ + +   
Sbjct: 1702 RDQLKENLRETITRDLE--KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLE 1759

Query: 289  SARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELE 348
             +    +++++Q   IQE+ R  +      L + + T+ +LR  + E      DK   ++
Sbjct: 1760 HSN---DALKAQDLKIQEELRIAHM----HLKEQQETIDKLRGIVSEKT----DKLSNMQ 1808

Query: 349  KQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDT 408
            K L  +N++L E         QE    + QL  L  D+++ +K++S  ++  K++ D+  
Sbjct: 1809 KDLENSNAKLQEK-------IQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQ-- 1859

Query: 409  GNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTA 468
              S+T+  L  E++N N+  Q+L   L+ +KS  +   ER       +   LE+   L  
Sbjct: 1860 --SLTLSKL--EIENLNL-AQKLHENLEEMKSVMK---ERDNLRRVEETLKLER-DQLKE 1910

Query: 469  QLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDL 528
             L+ TK    ++ +EL   +M  +  + T+  L   + EK   I     ++ K +  +  
Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK 1970

Query: 529  KLQELQ-------HLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQH 581
            K+QELQ        +K + +       E E LK Q   ++  ++ +R     +T+ + + 
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHE- 2029

Query: 582  GRTAGAMQVEKAQLEKEINDRRMELKE-LKILKDKKDAKIRELEARVSDLELEKVKLVNA 640
                    +E+ ++  +  D    +KE LK+ +D+  A +RE+ AR  D +  +VK    
Sbjct: 2030 -------SLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR--DRQNHQVK---- 2076

Query: 641  GSERLRAVKDIKQERDQLLNE----VKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNK 696
                 R + D +Q   + L E    +K      + + + YE L R   +  +E+E    +
Sbjct: 2077 --PEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQ-KE 2133

Query: 697  LKMQLKSAQS-ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEE 755
            L M++K+  S    QT++  K    +   +M               +   +  K++++  
Sbjct: 2134 LSMRVKANLSLPYLQTKHIEKLFTANQRCSM---------------EFHRIMKKLKYVLS 2178

Query: 756  AMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLR------SQERRLKEKVTNM 809
             +T   +E+H   E  +K   +      ++ ++  +++ L+      S+E R  +   NM
Sbjct: 2179 YVTKIKEEQH---ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNM 2235

Query: 810  EVALDKASLQFAEC---------QDIIQRQEQESVRLK--LQHTLDIKELQGPGYTSNSS 858
            ++ +++    F+E          Q ++  +++ +  L+  L    DI++L+      N  
Sbjct: 2236 DLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEND- 2294

Query: 859  LKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEE 918
               R+ Q  +   +      ++ST         ++ T+ ++  +DLK L ++   +    
Sbjct: 2295 ---RICQVNNFFNNRIIAIMNEST-----EFEERSATISKEWEQDLKSLKEKNEKLFKNY 2346

Query: 919  PAVSLSKTEEDGRTSLGALEDRVRDCITE--SSLRSDMCHRSNNSLRDSTEGSKSSET-- 974
              +  S     G       +D     +T   + L ++      NSL ++ E +   E+  
Sbjct: 2347 QTLKTSLAS--GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKI 2404

Query: 975  --------LSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLT 1026
                    ++ + +        + + C   T      +++  +    + P K  +  L  
Sbjct: 2405 IKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVA--LGAKPYKEEIEDLKM 2462

Query: 1027 SSVEGSIGSTSQYRS-AKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLE-SLQTLVEDLQ 1084
              V+  +      +   K I ++ +  + Q   I    +  R+ Q   + S+ +   D Q
Sbjct: 2463 KLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQ 2522

Query: 1085 LKNQAM-----SSMIRNQ------------EKRIQKVKDQEKMLLK 1113
              N+ +     S +++N             EK I K+K Q + L+K
Sbjct: 2523 PSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIK 2568



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 200/1108 (18%), Positives = 446/1108 (40%), Gaps = 170/1108 (15%)

Query: 109  RQSVIDLQTKLQEMQMERDAMADIRRRESQ--SQEDLRNQLQN----------------- 149
            R+ ++DL+ +L+E+ +E  A A  + + +Q   ++DL  ++QN                 
Sbjct: 349  RKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLT 408

Query: 150  TVHELEAAK------CL-KEDMLKDSN--------------------TQIEQLRKMMLSH 182
               EL+A +      CL K + +K+SN                      + ++ + + S 
Sbjct: 409  LQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSE 468

Query: 183  EGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKIL---RELDTEISYLKGR 239
              V       L + E     K+   +++ +    SL +    ++    +L TE   ++ +
Sbjct: 469  SDVFSNTLDTLSEIEWNPATKLLNQENIES-ELNSLRADYDNLVLDYEQLRTEKEEMELK 527

Query: 240  IFPVE--DQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSI 297
            +      D+ EAL+ +++   E+ L      ++ L+   EV    L  + SS        
Sbjct: 528  LKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREK 587

Query: 298  QSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSE 357
            + Q++ +QE   +Q      +L +++  +S     + + K+M        ++ L  A + 
Sbjct: 588  EDQIKKLQEYIDSQ------KLENIKMDLSYSLESIEDPKQM--------KQTLFDAETV 633

Query: 358  LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHL 417
              +A+ E      E+  L +++++L     + E ++ L + Q       +    + +D L
Sbjct: 634  ALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQ------LEAKKKMQVD-L 686

Query: 418  RRELDNRNMEVQRLEALLKALKSE---CQGQMERQMAAIQ-------GKNESLEKVSSLT 467
             +EL +   E+ +L +L+     +   C  ++E ++  +Q        +NE+L +   L 
Sbjct: 687  EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746

Query: 468  AQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVD 527
            ++L+S    + ++ +E+  K   L         L + +  KE  ++    EI K +   D
Sbjct: 747  SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKD--D 804

Query: 528  LKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVI----EILRQQIENMTQLVGQHGR 583
            L   +  + K+     +N +T    L +   +K K++    E + Q+I N+++   +   
Sbjct: 805  LATTQ-SNYKSTDQEFQNFKT----LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859

Query: 584  TAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSE 643
            + GA++ E +   +E+ ++  E++E     ++   ++   ++ +  +E EK  +     +
Sbjct: 860  SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919

Query: 644  RLRAVKDIKQERD---QLLNEVKTSRSELN-------NLSEEYEVLKRNFRNKSEEMEMT 693
             L  VK + QE+D   QL   ++  R +L        N++ + +   RN     ++ + T
Sbjct: 920  TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979

Query: 694  TNKLKMQLKSAQS-ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQF 752
             N LK ++    S  L    NT ++ +  +     V +  ++ + AK  Q      K   
Sbjct: 980  INTLKSKISEEVSRNLHMEENTGETKD--EFQQKMVGIDKKQDLEAKNTQTLTADVK--- 1034

Query: 753  LEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGEL-------------------E 793
             +  +    ++   L +EK++L Q L +V  EK ++  +L                   E
Sbjct: 1035 -DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDE 1093

Query: 794  VLRSQERRLKEK--VTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGP 851
            + + QE   +EK      E  L +   + AE ++ ++ + Q+ ++ K Q  L+++E    
Sbjct: 1094 LKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ-LQEKQQQLLNVQEEMSE 1152

Query: 852  GYTSNSSLK--PRLLQPASVTRSHSNVPSSQSTASFLSHHS-----TKANTLKEDPTRDL 904
                 + ++     L+   +T  H      +       ++      TK   + ++  +  
Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSF 1212

Query: 905  KQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRD 964
            +     LR  I E  A  L   EE     +   E +     T   LR  +  ++   +  
Sbjct: 1213 ETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE----TIDELRRSVSEKTAQII-- 1266

Query: 965  STEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSL 1024
            +T+  + S T  +E + +   ++E             P+VK  +      +  +     L
Sbjct: 1267 NTQDLEKSHTKLQEEIPVLHEEQE-----------LLPNVKEVSETQETMNELE-----L 1310

Query: 1025 LTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQ 1084
            LT        +T      + +  ++  ++SQ        +  + L    ++L+T+ E L+
Sbjct: 1311 LTEQSTTKDSTTLARIEMERLRLNEKFQESQ--------EEIKSLTKERDNLKTIKEALE 1362

Query: 1085 LKNQAMSSMIRNQEKRIQKVKDQEKMLL 1112
            +K+  +   IR    +IQ+ + +++  L
Sbjct: 1363 VKHDQLKEHIRETLAKIQESQSKQEQSL 1390



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 166/853 (19%), Positives = 361/853 (42%), Gaps = 144/853 (16%)

Query: 311  QNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQ 370
            +N+ Y+ ++S  E+ + + R E+ + K+  E+ + E   Q +           E+DQ +Q
Sbjct: 330  KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAM-----------EKDQLAQ 378

Query: 371  ESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRD----TGNSITIDHLRRELDNRNM 426
                       LL      EK+L L+K QN+++ +      T +S+T+            
Sbjct: 379  -----------LL-----EEKDL-LQKVQNEKIENLTRMLVTSSSLTLQ----------- 410

Query: 427  EVQRLEALLKALKSECQGQMERQMAAIQGKNESLE-KVSSLTAQLESTKEMLRKVVEELT 485
              Q L+A  K   + C G++ +   +      ++   +++ T +L     +LR++ E + 
Sbjct: 411  --QELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN--LLREIDESVC 466

Query: 486  AKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL-- 543
            ++     ++  T+S++  +   K    E   +E+  LR+  D  + + + L+ E + +  
Sbjct: 467  SESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMEL 526

Query: 544  ----RNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEI 599
                +N   E EAL+ + T+KD+ ++++  +I N+  LV +H       +V    LE E+
Sbjct: 527  KLKEKNDLDEFEALE-RKTKKDQEMQLI-HEISNLKNLV-KHA------EVYNQDLENEL 577

Query: 600  NDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLL 659
            + +      +++L++K+D +I++L+  +   +LE +K+  + S  L +++D KQ +  L 
Sbjct: 578  SSK------VELLREKED-QIKKLQEYIDSQKLENIKMDLSYS--LESIEDPKQMKQTLF 628

Query: 660  N----------EVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLK---SAQS 706
            +          E    RSE   L E+ + L   ++    ++++  ++L+ + K     + 
Sbjct: 629  DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688

Query: 707  ELEQTRNTLKSMEG-SDGHAMKVAM----------GMQKQITAKRGQIDALQSKIQFLEE 755
            EL+   N +  +    DG   K  +           +QK++  +  + +AL+ ++  L E
Sbjct: 689  ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSE 748

Query: 756  AMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDK 815
              +  ++ +   KE + K S+EL  + +EK+K+  E+    S+ + L E++        K
Sbjct: 749  LKSLPSEVERLRKEIQDK-SEELHIITSEKDKLFSEVVHKESRVQGLLEEI-------GK 800

Query: 816  ASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQ-PASVTRSHS 874
                 A  Q   +  +QE    K  H +D ++        N  +   ++       +  S
Sbjct: 801  TKDDLATTQSNYKSTDQEFQNFKTLH-MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859

Query: 875  NVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQEL-------------RSVINEEPAV 921
            ++ + ++  S+ +    +     ++   +++QL ++L             +++I E+   
Sbjct: 860  SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919

Query: 922  SLS--KTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREP 979
            +L   KT    +  L  L++ ++  I    L+SD+    N ++    +   + E+L +  
Sbjct: 920  TLEEVKTLTQEKDDLKQLQESLQ--IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ 977

Query: 980  VTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQY 1039
             T++           T  S  S  V  +     N+   K      +       I      
Sbjct: 978  ETIN-----------TLKSKISEEVSRNLHMEENTGETKDEFQQKMV-----GIDKKQDL 1021

Query: 1040 RSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEK 1099
             +      +  VKD++   IE   K    +Q + E  Q L   +  K Q  + +  N E 
Sbjct: 1022 EAKNTQTLTADVKDNEI--IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079

Query: 1100 RIQKVKDQEKMLL 1112
             I+   +QE++ L
Sbjct: 1080 TIE---NQEELRL 1089



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 161/907 (17%), Positives = 360/907 (39%), Gaps = 181/907 (19%)

Query: 58   EVELDSPRKIIPSPGKEHFERV------LEEYSHQVKDLQRRLNESNELHEKQKFYLRQS 111
            ++E     KI+    KEH E +      + E ++++ ++Q+ L  SN+  + Q   +++ 
Sbjct: 1716 DLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEE 1775

Query: 112  VIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQ 171
            +      L+E Q   D +  I   ++    +++  L+N+  +L+     K   LK +  Q
Sbjct: 1776 LRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE----KIQELKANEHQ 1831

Query: 172  IEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDT 231
            +  L+K +   +  + E+  +    ++ S        ++S L   +L  A  K+   L+ 
Sbjct: 1832 LITLKKDVNETQKKVSEMEQLKKQIKDQSL-------TLSKLEIENLNLA-QKLHENLEE 1883

Query: 232  EISYLKGR--IFPVEDQLEALKSESQNKIE------LLLQQHQDRIEQLISEHEVEITGL 283
              S +K R  +  VE+ L+  + + +  ++      L +QQ       L  EH+  +  L
Sbjct: 1884 MKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKL 1943

Query: 284  TEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDK 343
             EK S    Q + IQ  ++  +++ + +    +++L   E  + +++ ++  + +   + 
Sbjct: 1944 REKISEKTIQISDIQKDLDKSKDELQKK----IQELQKKELQLLRVKEDVNMSHKKINEM 1999

Query: 344  TEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRL 403
             E+L+KQ    N  +   R +  Q +++   L + L+++     +R+ EL   KE  K  
Sbjct: 2000 -EQLKKQFEAQNLSMQSVRMDNFQLTKK---LHESLEEIRIVAKERD-ELRRIKESLKM- 2053

Query: 404  WDRDTGNSITIDHLRRELDNRNMEVQRL------EALLKALKSECQGQME--RQMAAIQG 455
             +RD   +   + + R+  N  ++ ++       + L ++L+ +C    E  ++ + +  
Sbjct: 2054 -ERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD 2112

Query: 456  KNESLEKVS-SLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEA 514
              E L ++S  L  ++E  KE+  +V   L+   +  +  E+  +       E  R ++ 
Sbjct: 2113 HYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKK 2172

Query: 515  TN---AEITKLRSRVDLKLQ--------ELQHLKNEGDHLRNVQTECEA-------LKLQ 556
                 + +TK++      +         E++  K     ++++Q +C+        LKL 
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN 2232

Query: 557  MTEKDKVIEILR--------------QQI----ENMTQLVGQHGRTAGAMQVEKAQLEKE 598
                  + EIL+              QQ+    + MTQ + +   T   ++  K  ++KE
Sbjct: 2233 QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292

Query: 599  INDRRMEL------------------------------KELKILKDK------------- 615
             NDR  ++                              ++LK LK+K             
Sbjct: 2293 -NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKT 2351

Query: 616  ------------KDAKIRELEARVSDLELEKVK-LVNAGSERLRAVKDIKQERDQLLNEV 662
                        +D K   + +R + L  EK++ L N+  E   +    + +  ++  E+
Sbjct: 2352 SLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL 2411

Query: 663  KTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSD 722
            + +   +  L  +     +      E +++  +K+ +  K  + E+E  +  L  +   D
Sbjct: 2412 EVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKI---D 2468

Query: 723  GHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNAN--------------------- 761
               MK A   +K+I+A +  ++  +  I+ L E +  +                      
Sbjct: 2469 LEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPL 2528

Query: 762  -----------------KEKHF-LKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLK 803
                             K +H  L++E SKL Q+   +  +KN++    + L ++ +  K
Sbjct: 2529 TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWK 2588

Query: 804  EKVTNME 810
            E+    E
Sbjct: 2589 ERTLKRE 2595



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 141/710 (19%), Positives = 297/710 (41%), Gaps = 101/710 (14%)

Query: 58   EVELDSPRKIIPSPGKEHFERV------LEEYSHQVKDLQRRLNESNELHEKQKFYLRQS 111
            ++E+    K      KEH E V      + E + Q+ D+Q+ L++S +            
Sbjct: 1919 DLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD------------ 1966

Query: 112  VIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQ 171
              +LQ K+QE+Q +   +  ++   + S + + N+++    + EA     + +  D+   
Sbjct: 1967 --ELQKKIQELQKKELQLLRVKEDVNMSHKKI-NEMEQLKKQFEAQNLSMQSVRMDNF-- 2021

Query: 172  IEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDT 231
              QL K +  HE  L+EIR +  + +E   ++I E   M    F  + +    I R+   
Sbjct: 2022 --QLTKKL--HES-LEEIRIVAKERDEL--RRIKESLKMERDQF--IATLREMIARDRQN 2072

Query: 232  EISYLKGRIFPVEDQ--LEALKSESQNKIELL-----LQQHQDRIEQLISEHEVEITGLT 284
                 + R+     Q   E+L+ +     ELL     +  H + + +L  + E EI    
Sbjct: 2073 HQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQK 2132

Query: 285  EKASSARSQANSIQSQMEIIQE--QARNQNSM----YMRQLSDLESTVSQLRSELREAKR 338
            E +   ++  +    Q + I++   A  + SM     M++L  + S V++++ E  E+  
Sbjct: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESIN 2192

Query: 339  MYE-DKTEELEKQLVLANSELTEARTERDQFSQE------SGNLDDQLQKLLADLHKRE- 390
             +E D  +E+EKQ  L   ++   + + D  S+E      + N+D  ++++L D  + E 
Sbjct: 2193 KFEMDFIDEVEKQKELL-IKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEF 2251

Query: 391  --------------KELS--LEKEQNKRLWDRDTGNSIT-----IDHLRRELDNRNMEVQ 429
                          KE++  LE+  N R       N I      I  +    +NR + + 
Sbjct: 2252 PSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIM 2311

Query: 430  RLEALLKALKSECQGQMERQMAAIQGKNESLEK-VSSLTAQLES---------------- 472
                  +   +    + E+ + +++ KNE L K   +L   L S                
Sbjct: 2312 NESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHV 2371

Query: 473  TKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQE 532
            T    +   E++   + +L  ++ +     + + + ++ +E TN  I KL+++V    + 
Sbjct: 2372 TSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC 2431

Query: 533  LQHLKNEGDHLRN-VQTECEALKLQMTE-KDKVIEILRQQIENMTQLVGQHGRTAGAMQV 590
            L+  K     L++ V    +  K ++ + K K+++I  ++++N  +   +   T   ++ 
Sbjct: 2432 LEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEY 2491

Query: 591  EKA--QLEKEINDRRMELKELKILKDKKDAKI--RELEARVSDLELEKVKLVNAGSERLR 646
            +K   +L +E   R  + ++  ++ +  D +   + L        ++  K +   SE +R
Sbjct: 2492 QKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIR 2551

Query: 647  AVKDI---KQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMT 693
              K+I   KQ+ +QL+ +     S   +LS E +  K     +    ++T
Sbjct: 2552 LEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVT 2601


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  130 bits (328), Expect = 5e-30
 Identities = 168/843 (19%), Positives = 377/843 (44%), Gaps = 109/843 (12%)

Query: 58   EVELDSPRKIIPSPGKEHFERV--LEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDL 115
            E ++D  R ++ +  +E  E +  LEE   +V+DLQ R+ E +         + +  ++ 
Sbjct: 407  EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEES---------ITKGDLET 457

Query: 116  QTKLQEMQMER--DAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIE 173
            QTKL+  +++    ++   + +  + Q +L +    TV E      L++D+      ++ 
Sbjct: 458  QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQ-EVA 516

Query: 174  QLRKMMLSHE---------GVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISK 224
            +LR+ + S++          +LQEI S+    E        E  S+   HF +      K
Sbjct: 517  ELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE-HFGAREETHQK 575

Query: 225  ILRELDTEISYLKGRIFPVEDQLEALKSES-------QNKIELLLQQHQDRIEQLISEHE 277
             ++ L T    L      ++ +LE    E+       ++K+E  +  HQ  +E+L     
Sbjct: 576  EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS 635

Query: 278  VEITGLTEKASSARSQANSI----QSQMEIIQEQARNQNSMYMRQLSDL----------- 322
              +   T + +  ++Q   +    Q ++E +Q Q  ++ + + +++  L           
Sbjct: 636  KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 695

Query: 323  ESTVSQLRSELREAKRMY----EDKTEELE------KQLVLANSELTEARTERDQFSQES 372
            E+++  +RS+L +A+  +    ED   +L+      K+L +  ++  E     D F+ + 
Sbjct: 696  ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 755

Query: 373  GNLDDQLQKLLA----------DLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELD 422
               +++L  L A          ++ K  ++L   ++Q K L       S     + REL 
Sbjct: 756  KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ 815

Query: 423  NRNMEVQRLEALLKALKSECQGQMERQMAAIQGK-NESLEKVSSLTAQLESTKEMLRKVV 481
             R +++  L+  L  + S+ +  +E+++  ++ K  E+ E+  S+   ++ T   L +  
Sbjct: 816  GRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE 874

Query: 482  EELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG- 540
            E+       LE     ++D+    +EK+   E    ++ K + +++  + E+  +  +  
Sbjct: 875  EQFNMLSSDLEKLRENLADMEAKFREKDEREE----QLIKAKEKLENDIAEIMKMSGDNS 930

Query: 541  -------DHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAM-QVEK 592
                   D LR  + + E L+L++T+ ++    L++ IE+MT    Q  + A    + EK
Sbjct: 931  SQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK 990

Query: 593  AQLEKEIND--RRMELK--ELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAV 648
             +LE++++D  ++ME    + + LK + +    E + +  ++     K +    ++L   
Sbjct: 991  KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL--- 1047

Query: 649  KDIKQERDQLLNEVKTSRSELNNLS------EEYEVLKRNFRNKSEEMEMTTNKLKMQLK 702
            K  ++E   LL E++  R + +         +  +++++  + K+E +    +  +   K
Sbjct: 1048 KGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107

Query: 703  SAQSELEQTR-NTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNAN 761
              Q+EL+  + N LK++E  +          ++ +T +  +++  + +I+ L++A    +
Sbjct: 1108 -LQNELDTLKENNLKNVEELNKS--------KELLTVENQKMEEFRKEIETLKQAAAQKS 1158

Query: 762  KEKHFLKEEKSKLSQELS---TVATEKNKMAGELEVLRSQERRLKEKVTNM--EVALDKA 816
            ++   L+EE  KL++EL       T   K+  E  VL +Q   +K++ +    +   +KA
Sbjct: 1159 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 1218

Query: 817  SLQ 819
            SLQ
Sbjct: 1219 SLQ 1221



 Score =  127 bits (320), Expect = 4e-29
 Identities = 147/742 (19%), Positives = 331/742 (44%), Gaps = 65/742 (8%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVID-LQTKLQEMQMERDAMAD 131
            K   E++  +Y H++++LQ + +     H K+   LR  ++  ++ K   ++  R  +  
Sbjct: 649  KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 708

Query: 132  IRRRESQSQEDLRNQLQNT---VHELEA--AKCLKEDMLKDSNTQ-----------IEQL 175
               +     ED  N+LQ     V ELE   AKC ++  + D+ T            ++ L
Sbjct: 709  AEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 768

Query: 176  RKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISY 235
            RK     +  ++++R  L    EA+ K+I +H  +      S  S+I++ L+  + +++ 
Sbjct: 769  RKASSEGKSEMKKLRQQL----EAAEKQI-KHLEIEKNAESSKASSITRELQGRELKLTN 823

Query: 236  LKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQAN 295
            L+  +  V    E L+ E    +++L ++  +  E+ +S     +     K      Q N
Sbjct: 824  LQENLSEVSQVKETLEKE----LQILKEKFAEASEEAVSVQR-SMQETVNKLHQKEEQFN 878

Query: 296  SIQSQMEIIQEQARNQNSMYMRQLSDLESTVS---QLRSELREAKRMYEDKTEELEK--- 349
             + S +E ++E   +  + +  +    E  +    +L +++ E  +M  D + +L K   
Sbjct: 879  MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938

Query: 350  QLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG 409
            +L L   ++ E + +  + ++ +  L   ++ +     + ++E + + E+ K+  +R   
Sbjct: 939  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK-- 996

Query: 410  NSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQ----GKNESLEKVSS 465
                +  L ++++  + + Q L+A  +   SE + + E  +  +Q       + L+    
Sbjct: 997  ----LSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE 1052

Query: 466  LTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSR 525
              + L    E LRK  ++  A + T E + + +  +T    E   ++E T     KL++ 
Sbjct: 1053 ENSGLLQELEELRKQADKAKAAQ-TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1111

Query: 526  VDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTA 585
            +D  L+E        ++L+NV+ E    K  +T +++ +E  R++IE + Q   Q  +  
Sbjct: 1112 LDT-LKE--------NNLKNVE-ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQL 1161

Query: 586  GAMQVEKAQLEKEINDRRMELKELKILKDKKDA---KIRELEAR----VSDLELEKVKLV 638
             A+Q E  +L +E+   R E+   + L++++     ++ E++ R    + D + EK  L 
Sbjct: 1162 SALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ 1221

Query: 639  NAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLK 698
             + S     + +   E ++L NEV   R E N  ++    + +   +   ++E+    L+
Sbjct: 1222 KSISITSALLTEKDAELEKLRNEVTVLRGE-NASAKSLHSVVQTLESDKVKLELKVKNLE 1280

Query: 699  MQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMG-MQKQITAKRGQIDALQSKIQFLEEAM 757
            +QLK  + +L  +     +    D  A +  +  +   I   + +   L+ K++ + EA 
Sbjct: 1281 LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAA 1340

Query: 758  TNANKE--KHFLKEEKSKLSQE 777
             N N +   ++  +++ K S++
Sbjct: 1341 LNGNGDDLNNYDSDDQEKQSKK 1362



 Score =  117 bits (294), Expect = 5e-26
 Identities = 208/955 (21%), Positives = 401/955 (41%), Gaps = 150/955 (15%)

Query: 249  ALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQA 308
            A K      ++  L++ Q  IEQL++E ++E      + + A S    I+ ++ + ++  
Sbjct: 344  ARKISGTTALQEALKEKQQHIEQLLAERDLE----RAEVAKATSHVGEIEQELALARDG- 398

Query: 309  RNQNSMYMRQLSDLESTVSQLR--------------SELREAKRMYEDKTEELEKQLVLA 354
                  + + + +LE+ + QLR              ++L E KR  ED    +E++ +  
Sbjct: 399  ------HDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITK 452

Query: 355  NSELTEARTERDQFSQESGNL------DDQLQKLLAD-----------LHKREKELSL-- 395
                T+ + E  +  +   +L       D+LQ+ L D           + + EK+L+L  
Sbjct: 453  GDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRV 512

Query: 396  --------EKEQNKRLWDRDTGNSI--TIDHLRRELDNRNMEVQRLEALLKALKSECQGQ 445
                      E NK   D D   S+   I  L+ +L+    + QR    LK      +  
Sbjct: 513  QEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREET 572

Query: 446  MERQMAAIQGKNESLEKVS-SLTAQLESTKEMLRKVVEELTAKKMT-LESSERTISDLTT 503
             ++++ A+    E L K + SL ++LE   +    V+    +K  T + S ++ + +L  
Sbjct: 573  HQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV 632

Query: 504  SLQEKERAIEATNAEITKLRSRVD-LKL---QELQHLKNEGDHLRNVQT-ECEALKLQM- 557
            S     + +    AE  +L+++++ ++L    E+++L+N+ D  R     E EAL+ ++ 
Sbjct: 633  SF---SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 689

Query: 558  ---TEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKD 614
                EK+  +E +R +++       QH        VE      ++ +  +++KEL++L+ 
Sbjct: 690  KVIKEKENSLEAIRSKLDKAED---QH-------LVEMEDTLNKLQEAEIKVKELEVLQA 739

Query: 615  KKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSE 674
            K + + + ++   S L+  + KL++  + R +A  + K E  +L  +++ +  ++ +L  
Sbjct: 740  KCNEQTKVIDNFTSQLKATEEKLLDLDALR-KASSEGKSEMKKLRQQLEAAEKQIKHL-- 796

Query: 675  EYEVLKRNFRNKSEEMEMTTNKLKM-QLKSAQSELEQTRNTL---------KSMEGSDGH 724
            E E    + +  S   E+   +LK+  L+   SE+ Q + TL         K  E S+  
Sbjct: 797  EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASE-E 855

Query: 725  AMKVAMGMQKQIT---AKRGQIDALQSKIQFLEEAMTNAN---KEKHFLKEEKSKLSQEL 778
            A+ V   MQ+ +     K  Q + L S ++ L E + +     +EK   +E+  K  ++L
Sbjct: 856  AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 915

Query: 779  STVATEKNKMAGE--------LEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQ 830
                 E  KM+G+         + LR +ER ++E    +  A + AS      +D+  + 
Sbjct: 916  ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 975

Query: 831  EQESVRLKLQHTLDIKELQ----------GPGYTSNSSLKPRLLQPASVTRS-HSNVPSS 879
            EQ       +H  + KEL+             +     LK R  +  S T++ H  +   
Sbjct: 976  EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI--L 1033

Query: 880  QSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDG--------- 930
            Q+    L     K    +E+ +     LLQEL  +  +      ++T ED          
Sbjct: 1034 QNLQKTLLDTEDKLKGAREENS----GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1089

Query: 931  --RTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDRE 988
                +L +LED  +   T + L++++     N+L++  E +KS E L+ E   +    +E
Sbjct: 1090 EKTETLASLEDTKQ---TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKE 1146

Query: 989  DPSGCFTFTSAASPSVKNSASRSFN--------SSPKKSPVHSLLTS--SVEGSIGSTSQ 1038
              +      +AA  S + SA +  N         S  +   H  L    SV  +     +
Sbjct: 1147 IET---LKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK 1203

Query: 1039 YRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMSSM 1093
             R +K I  +D  K S    I  T     +    LE L+  V  L+ +N +  S+
Sbjct: 1204 KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL 1258



 Score =  116 bits (291), Expect = 1e-25
 Identities = 207/1007 (20%), Positives = 403/1007 (40%), Gaps = 171/1007 (16%)

Query: 222  ISKILRELD---TEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEV 278
            I ++L E D    E++     +  +E +L AL  +  ++  L L+   D++  ++   + 
Sbjct: 364  IEQLLAERDLERAEVAKATSHVGEIEQEL-ALARDGHDQHVLELEAKMDQLRTMVEAADR 422

Query: 279  EITGLTEKASSARSQANSIQSQME---IIQEQARNQNSMYMRQLSDLESTVSQLRSELRE 335
            E   L  +    + +   +Q ++E   I +     Q  +   ++ +LE ++   +++  +
Sbjct: 423  EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADK 482

Query: 336  AKRMYED----------KTEELEKQLVLANSELTEARTERDQ------------FSQESG 373
             +R  ED          +  ELEK L L   E+ E R   +               QE  
Sbjct: 483  LQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS 542

Query: 374  NLDDQLQKLLADLHKRE----------KELSLEKEQNKRLWDRDTGNSITIDHLRRELDN 423
            +L ++L+    D H+RE          +E + +KE  K L+      S   + L+ +L++
Sbjct: 543  SLQEKLEVTRTD-HQREITSLKEHFGAREETHQKEI-KALYTATEKLSKENESLKSKLEH 600

Query: 424  RNMEVQRLEALLK-----ALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLR 478
             N E   + AL K     A+ S  Q   E +++  +G      + + L  Q+E  +   +
Sbjct: 601  ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660

Query: 479  KVVEEL-----TAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQEL 533
              +E L     + +    +  E   + L   ++EKE ++EA  +++ K     D  L E+
Sbjct: 661  HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE---DQHLVEM 717

Query: 534  QHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKA 593
            +   N+         E E L+ +  E+ KVI+    Q++   + +           ++  
Sbjct: 718  EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL-----------LDLD 766

Query: 594  QLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQ 653
             L K  ++ + E+K+L+        ++   E ++  LE+EK    NA S +  ++    Q
Sbjct: 767  ALRKASSEGKSEMKKLR-------QQLEAAEKQIKHLEIEK----NAESSKASSITRELQ 815

Query: 654  ERDQLLNEVKTSRSELNNLSE----EYEVLKRNFRNKSEE-------MEMTTNKLKM--- 699
             R+  L  ++ + SE++ + E    E ++LK  F   SEE       M+ T NKL     
Sbjct: 816  GRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 875

Query: 700  QLKSAQSELEQTRNTLKSMEGSD---------------------GHAMKVAMGMQKQITA 738
            Q     S+LE+ R  L  ME                           MK++     Q+T 
Sbjct: 876  QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 935

Query: 739  KRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQ 798
               ++   +  ++ L+  +T AN+   FL+    K  ++++  A +  + A +      +
Sbjct: 936  MNDELRLKERDVEELQLKLTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKH--EEE 989

Query: 799  ERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSS 858
            ++ L+ K++++E  ++ +  Q   CQ++  R E+ +   K +H   ++ LQ     +   
Sbjct: 990  KKELERKLSDLEKKMETSHNQ---CQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1046

Query: 859  LKPR------LLQPASVTRSHSNVPSSQSTASF---LSHHSTKANTLKEDPTRDLKQLLQ 909
            LK        LLQ     R  ++   +  TA     +    TK  T       D KQ   
Sbjct: 1047 LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1106

Query: 910  ELRSVINEEPAVSLSKTEEDGRTS--LGALEDRVRDCITE-SSLRSDMCHRSNNSLRDST 966
            +L++ ++     +L   EE  ++   L     ++ +   E  +L+     +S        
Sbjct: 1107 KLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQE 1166

Query: 967  EGSKSSETL--SREPVTLHAGDREDPS----GCFTFTSAASPSVKNSASRSFNSSPKKSP 1020
            E  K +E L  SR+ VT H    E+ S             S  +K++     +     S 
Sbjct: 1167 ENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISI 1226

Query: 1021 VHSLLT---SSVEGSIGSTSQYR----SAKPIHS------SDSVK-------------DS 1054
              +LLT   + +E      +  R    SAK +HS      SD VK             ++
Sbjct: 1227 TSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKEN 1286

Query: 1055 QSPPIETTGKTC-------RKLQNRLESLQTLVEDLQLKNQAMSSMI 1094
            +     ++G T        R  +++++ L +++ DLQ KNQ +   +
Sbjct: 1287 KRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV 1333


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  130 bits (327), Expect = 7e-30
 Identities = 220/997 (22%), Positives = 410/997 (41%), Gaps = 125/997 (12%)

Query: 70   SPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM 129
            S  ++  E  L E+S Q  + + ++   N+L  K +     ++ D++ +L++ +  R  +
Sbjct: 1023 SKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE----ATIADMEDRLRKEEKGRQEL 1078

Query: 130  ADIRRRESQSQEDLRNQL---QNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVL 186
              ++RR      +L+ Q+   Q    EL A    KE+ L+ +  + E            L
Sbjct: 1079 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSL 1138

Query: 187  QEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQ 246
            +E ++ L + +E    +            R   +   K  R+L  E+  L+G +    D 
Sbjct: 1139 REAQAALAEAQEDLESE------------RVARTKAEKQRRDLGEELEALRGELEDTLDS 1186

Query: 247  LEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQE 306
              A + E ++K E  + + +  +E+    HE  +  L ++   A  +   +  Q+E    
Sbjct: 1187 TNA-QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE---LAEQLE---- 1238

Query: 307  QARNQNSMYMRQLSDLESTVSQLRSEL---REAKRMYEDKTEELEKQL------------ 351
            QAR     + +    LE+ VS+LR+EL   + A++  E +   LE QL            
Sbjct: 1239 QARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1298

Query: 352  --VLANSELTEARTERDQFS-------QESGNLDDQLQKLLADLHKREKELSLEKEQNKR 402
                A  +L  A+ E +  S        ++  L  +L    A LH  ++ L  E      
Sbjct: 1299 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1358

Query: 403  LWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALK---SECQGQMERQMAAIQGKNES 459
            L  R          LR +L+      +R    L+  +   SE + + E +  A++   E+
Sbjct: 1359 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1418

Query: 460  LEKVS----SLTAQLESTKEML-------RKVVEELTAKKMTLESSERTISDLTTSLQEK 508
              + +    +LT +L    E +       R++ +EL    M LE   + +S    +L++K
Sbjct: 1419 RRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS----TLEKK 1474

Query: 509  ERAIEATNAE--ITKLRSRVDLKLQELQHLKNEGDHL---RNVQTECEALKLQMTEKDKV 563
            +R  +   AE     LR+  + +  E +  + E   L   R ++ E EA +    E ++ 
Sbjct: 1475 QRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEARE----ELERQ 1530

Query: 564  IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI-LKDKKDAKIRE 622
               LR ++E +       G++   ++      E+  ND R ++ EL+  L   +DAK+R 
Sbjct: 1531 NRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR- 1589

Query: 623  LEARVSDLELEKVKLVN----AGSERLRAV----KDIKQERDQLLNEVKTSRSELNNLSE 674
            LE  V  L+ +  + +     AG ER R +    +D + ERD+   +   + +    L  
Sbjct: 1590 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEG 1649

Query: 675  EYEVLKRNFRNKS---EEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMG 731
            E E LK    +     EE      K++ Q+K    E+E+TR + + +   +  + K   G
Sbjct: 1650 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKG 1709

Query: 732  MQKQI--------TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVAT 783
            ++ ++         + R +  A Q + +  +E + N N  K  + EEK +L   L  +  
Sbjct: 1710 LEAEVLRLQEELAASDRARRQAQQDRDEMADE-VANGNLSKAAILEEKRQLEGRLGQLEE 1768

Query: 784  EKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTL 843
            E  +     E+L  + R+L  +V ++   L  A   F+         + ES R +L+   
Sbjct: 1769 ELEEEQSNSELLNDRYRKLLLQVESLTTEL-SAERSFS--------AKAESGRQQLER-- 1817

Query: 844  DIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRD 903
             I+EL+G     ++  + R     +       + S  + A       T+   L     R 
Sbjct: 1818 QIQELRGRLGEEDAGARARHKMTIAA------LESKLAQAEEQLEQETRERILSGKLVRR 1871

Query: 904  LKQLLQELRSVINEEPAVS--LSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNS 961
             ++ L+E+   + EE  V+  L    E G   +  L+ ++ +   E+S       R    
Sbjct: 1872 AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRE 1931

Query: 962  LRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTS 998
            L D TE   S+E+++RE  TL    R  P    TFT+
Sbjct: 1932 LEDVTE---SAESMNREVTTLRNRLRRGP---LTFTT 1962



 Score =  102 bits (254), Expect = 2e-21
 Identities = 120/640 (18%), Positives = 269/640 (42%), Gaps = 47/640 (7%)

Query: 222  ISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDR---------IEQL 272
            + ++ ++   E+  L+GR+  +E++   L  + + + EL  +  + R         +E +
Sbjct: 889  VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 948

Query: 273  ISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLR-S 331
            +SE E  +    E+  S + Q    + Q  I + +A  +     RQ   LE   ++ +  
Sbjct: 949  VSELEARVG--EEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMK 1006

Query: 332  ELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREK 391
            +  E   + ED+  +L K+  L    L E  ++  +  ++  +L+    K  A +   E 
Sbjct: 1007 KFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1066

Query: 392  ELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMA 451
             L  E++  + L           + L+R LD  + E+Q      +    E + Q+ R+  
Sbjct: 1067 RLRKEEKGRQEL-----------EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1115

Query: 452  AIQGKNESLEKVSSLTAQL----ESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ- 506
             +Q      E      AQL       +  L +  E+L ++++    +E+   DL   L+ 
Sbjct: 1116 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1175

Query: 507  ---EKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKV 563
               E E  +++TNA+  +LRS+ + ++ EL+    E   +       EA   ++ ++   
Sbjct: 1176 LRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIH------EAAVQELRQRHG- 1227

Query: 564  IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIREL 623
                 Q +  + + + Q  R  GA +  +  LE E+++ R EL  L+  + + + + R L
Sbjct: 1228 -----QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRL 1282

Query: 624  EARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNF 683
            E ++ +++        A +E    ++  + E + +   +  + S+   LS+E    +   
Sbjct: 1283 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1342

Query: 684  RNKSEEMEMTTNK---LKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR 740
             +  E ++  T     L  ++++ ++E    R  L+    +   A +     Q Q++  R
Sbjct: 1343 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1402

Query: 741  GQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
             + +     ++  EEA   A +E   L +  ++ ++ +  +   + ++  EL+       
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1462

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ 840
            + ++ V+ +E    K     AE +  + R  +E  R + +
Sbjct: 1463 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE 1502



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 172/883 (19%), Positives = 334/883 (37%), Gaps = 122/883 (13%)

Query: 269  IEQLISEHEVEITGL------TEKASSARSQANSIQSQMEIIQEQARN-------QNSMY 315
            + QL  E ++++T +        +   AR      Q Q   ++   RN       ++  +
Sbjct: 800  LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQW 859

Query: 316  MRQLSDLESTVSQLRS-ELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGN 374
             R  + ++  +   R  E+ +A+     K +EL++Q   +  E+ E +    Q  +E   
Sbjct: 860  WRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQ---SAREVGELQGRVAQLEEERAR 916

Query: 375  LDDQLQKLLADLHKREKELSLEKEQNK-RLWDRDTGNSITIDHLRRELDNRNMEVQRLEA 433
            L +QL        + E EL  E E+ + RL  R     + +  L   +       ++++ 
Sbjct: 917  LAEQL--------RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 968

Query: 434  LLKALKSECQGQMERQMAAIQGKNESL--EKVSSLTAQLESTKE---MLRKVVEELTAKK 488
              K L+   Q ++E  + A +G  + L  EKV++  A+++  +E   +L     +L+ ++
Sbjct: 969  EKKRLQQHIQ-ELEAHLEAEEGARQKLQLEKVTT-EAKMKKFEEDLLLLEDQNSKLSKER 1026

Query: 489  MTLESSERTISDLTTSLQEKERAI-------EATNAEITKLRSRVDLKLQELQHLKNEGD 541
              LE      S      +EK +++       EAT A++     + +   QEL+ LK    
Sbjct: 1027 KLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLK---- 1082

Query: 542  HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIND 601
              R +  E   L+ QM E+ +  E LR Q+          GR    +Q   A+ E E   
Sbjct: 1083 --RRLDGESSELQEQMVEQQQRAEELRAQL----------GRKEEELQAALARAEDEGGA 1130

Query: 602  RRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
            R   LK L+      +A+    EA+  DLE E+V    A  +R    +D+ +E + L  E
Sbjct: 1131 RAQLLKSLR------EAQAALAEAQ-EDLESERVARTKAEKQR----RDLGEELEALRGE 1179

Query: 662  VKTSRSELNNLSE-----EYEV--LKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNT 714
            ++ +    N   E     E EV  LK+    ++   E    +L+ +   A  EL +    
Sbjct: 1180 LEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQ--- 1236

Query: 715  LKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKL 774
            L+      G   K  + ++ +++  R ++ +LQ+  Q  E+       +   ++      
Sbjct: 1237 LEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG 1296

Query: 775  SQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQES 834
             +  +  A +  +   ELE +       + K   +   L     Q  + Q+++Q  E+  
Sbjct: 1297 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ--EETR 1354

Query: 835  VRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVT-RSHSNVPSSQSTAS-FLSHHSTK 892
             +L L   +   E +  G      L+ +L + A+   R+   + ++Q+  S +      +
Sbjct: 1355 AKLALGSRVRAMEAEAAG------LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEE 1408

Query: 893  ANTL------KEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCIT 946
            A  L      +    R+ + L Q L      E   ++ + E   R     L+D   D   
Sbjct: 1409 AGALEAGEEARRRAAREAEALTQRLA-----EKTETVDRLERGRRRLQQELDDATMDLEQ 1463

Query: 947  ESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKN 1006
            +  L S +  +     +   E   +      E     A  RE  +   + T A     + 
Sbjct: 1464 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1523

Query: 1007 SASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTC 1066
                   +   ++ + +LL+S                        KD     +    + C
Sbjct: 1524 REELERQNRALRAELEALLSS------------------------KDDVGKSVHELERAC 1559

Query: 1067 RKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQEK 1109
            R  +     L+  V +L+ +  A        E  +Q +K Q +
Sbjct: 1560 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE 1602


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  130 bits (327), Expect = 7e-30
 Identities = 220/997 (22%), Positives = 410/997 (41%), Gaps = 125/997 (12%)

Query: 70   SPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM 129
            S  ++  E  L E+S Q  + + ++   N+L  K +     ++ D++ +L++ +  R  +
Sbjct: 1015 SKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE----ATIADMEDRLRKEEKGRQEL 1070

Query: 130  ADIRRRESQSQEDLRNQL---QNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVL 186
              ++RR      +L+ Q+   Q    EL A    KE+ L+ +  + E            L
Sbjct: 1071 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSL 1130

Query: 187  QEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQ 246
            +E ++ L + +E    +            R   +   K  R+L  E+  L+G +    D 
Sbjct: 1131 REAQAALAEAQEDLESE------------RVARTKAEKQRRDLGEELEALRGELEDTLDS 1178

Query: 247  LEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQE 306
              A + E ++K E  + + +  +E+    HE  +  L ++   A  +   +  Q+E    
Sbjct: 1179 TNA-QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE---LAEQLE---- 1230

Query: 307  QARNQNSMYMRQLSDLESTVSQLRSEL---REAKRMYEDKTEELEKQL------------ 351
            QAR     + +    LE+ VS+LR+EL   + A++  E +   LE QL            
Sbjct: 1231 QARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1290

Query: 352  --VLANSELTEARTERDQFS-------QESGNLDDQLQKLLADLHKREKELSLEKEQNKR 402
                A  +L  A+ E +  S        ++  L  +L    A LH  ++ L  E      
Sbjct: 1291 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1350

Query: 403  LWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALK---SECQGQMERQMAAIQGKNES 459
            L  R          LR +L+      +R    L+  +   SE + + E +  A++   E+
Sbjct: 1351 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1410

Query: 460  LEKVS----SLTAQLESTKEML-------RKVVEELTAKKMTLESSERTISDLTTSLQEK 508
              + +    +LT +L    E +       R++ +EL    M LE   + +S    +L++K
Sbjct: 1411 RRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS----TLEKK 1466

Query: 509  ERAIEATNAE--ITKLRSRVDLKLQELQHLKNEGDHL---RNVQTECEALKLQMTEKDKV 563
            +R  +   AE     LR+  + +  E +  + E   L   R ++ E EA +    E ++ 
Sbjct: 1467 QRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEARE----ELERQ 1522

Query: 564  IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI-LKDKKDAKIRE 622
               LR ++E +       G++   ++      E+  ND R ++ EL+  L   +DAK+R 
Sbjct: 1523 NRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR- 1581

Query: 623  LEARVSDLELEKVKLVN----AGSERLRAV----KDIKQERDQLLNEVKTSRSELNNLSE 674
            LE  V  L+ +  + +     AG ER R +    +D + ERD+   +   + +    L  
Sbjct: 1582 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEG 1641

Query: 675  EYEVLKRNFRNKS---EEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMG 731
            E E LK    +     EE      K++ Q+K    E+E+TR + + +   +  + K   G
Sbjct: 1642 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKG 1701

Query: 732  MQKQI--------TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVAT 783
            ++ ++         + R +  A Q + +  +E + N N  K  + EEK +L   L  +  
Sbjct: 1702 LEAEVLRLQEELAASDRARRQAQQDRDEMADE-VANGNLSKAAILEEKRQLEGRLGQLEE 1760

Query: 784  EKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTL 843
            E  +     E+L  + R+L  +V ++   L  A   F+         + ES R +L+   
Sbjct: 1761 ELEEEQSNSELLNDRYRKLLLQVESLTTEL-SAERSFS--------AKAESGRQQLER-- 1809

Query: 844  DIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRD 903
             I+EL+G     ++  + R     +       + S  + A       T+   L     R 
Sbjct: 1810 QIQELRGRLGEEDAGARARHKMTIAA------LESKLAQAEEQLEQETRERILSGKLVRR 1863

Query: 904  LKQLLQELRSVINEEPAVS--LSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNS 961
             ++ L+E+   + EE  V+  L    E G   +  L+ ++ +   E+S       R    
Sbjct: 1864 AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRE 1923

Query: 962  LRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTS 998
            L D TE   S+E+++RE  TL    R  P    TFT+
Sbjct: 1924 LEDVTE---SAESMNREVTTLRNRLRRGP---LTFTT 1954



 Score =  102 bits (254), Expect = 2e-21
 Identities = 120/640 (18%), Positives = 269/640 (42%), Gaps = 47/640 (7%)

Query: 222  ISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDR---------IEQL 272
            + ++ ++   E+  L+GR+  +E++   L  + + + EL  +  + R         +E +
Sbjct: 881  VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 940

Query: 273  ISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLR-S 331
            +SE E  +    E+  S + Q    + Q  I + +A  +     RQ   LE   ++ +  
Sbjct: 941  VSELEARVG--EEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMK 998

Query: 332  ELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREK 391
            +  E   + ED+  +L K+  L    L E  ++  +  ++  +L+    K  A +   E 
Sbjct: 999  KFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1058

Query: 392  ELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMA 451
             L  E++  + L           + L+R LD  + E+Q      +    E + Q+ R+  
Sbjct: 1059 RLRKEEKGRQEL-----------EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1107

Query: 452  AIQGKNESLEKVSSLTAQL----ESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ- 506
             +Q      E      AQL       +  L +  E+L ++++    +E+   DL   L+ 
Sbjct: 1108 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1167

Query: 507  ---EKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKV 563
               E E  +++TNA+  +LRS+ + ++ EL+    E   +       EA   ++ ++   
Sbjct: 1168 LRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIH------EAAVQELRQRHG- 1219

Query: 564  IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIREL 623
                 Q +  + + + Q  R  GA +  +  LE E+++ R EL  L+  + + + + R L
Sbjct: 1220 -----QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRL 1274

Query: 624  EARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNF 683
            E ++ +++        A +E    ++  + E + +   +  + S+   LS+E    +   
Sbjct: 1275 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1334

Query: 684  RNKSEEMEMTTNK---LKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR 740
             +  E ++  T     L  ++++ ++E    R  L+    +   A +     Q Q++  R
Sbjct: 1335 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1394

Query: 741  GQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
             + +     ++  EEA   A +E   L +  ++ ++ +  +   + ++  EL+       
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1454

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ 840
            + ++ V+ +E    K     AE +  + R  +E  R + +
Sbjct: 1455 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE 1494



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 172/883 (19%), Positives = 334/883 (37%), Gaps = 122/883 (13%)

Query: 269  IEQLISEHEVEITGL------TEKASSARSQANSIQSQMEIIQEQARN-------QNSMY 315
            + QL  E ++++T +        +   AR      Q Q   ++   RN       ++  +
Sbjct: 792  LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQW 851

Query: 316  MRQLSDLESTVSQLRS-ELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGN 374
             R  + ++  +   R  E+ +A+     K +EL++Q   +  E+ E +    Q  +E   
Sbjct: 852  WRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQ---SAREVGELQGRVAQLEEERAR 908

Query: 375  LDDQLQKLLADLHKREKELSLEKEQNK-RLWDRDTGNSITIDHLRRELDNRNMEVQRLEA 433
            L +QL        + E EL  E E+ + RL  R     + +  L   +       ++++ 
Sbjct: 909  LAEQL--------RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 960

Query: 434  LLKALKSECQGQMERQMAAIQGKNESL--EKVSSLTAQLESTKE---MLRKVVEELTAKK 488
              K L+   Q ++E  + A +G  + L  EKV++  A+++  +E   +L     +L+ ++
Sbjct: 961  EKKRLQQHIQ-ELEAHLEAEEGARQKLQLEKVTT-EAKMKKFEEDLLLLEDQNSKLSKER 1018

Query: 489  MTLESSERTISDLTTSLQEKERAI-------EATNAEITKLRSRVDLKLQELQHLKNEGD 541
              LE      S      +EK +++       EAT A++     + +   QEL+ LK    
Sbjct: 1019 KLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLK---- 1074

Query: 542  HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIND 601
              R +  E   L+ QM E+ +  E LR Q+          GR    +Q   A+ E E   
Sbjct: 1075 --RRLDGESSELQEQMVEQQQRAEELRAQL----------GRKEEELQAALARAEDEGGA 1122

Query: 602  RRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
            R   LK L+      +A+    EA+  DLE E+V    A  +R    +D+ +E + L  E
Sbjct: 1123 RAQLLKSLR------EAQAALAEAQ-EDLESERVARTKAEKQR----RDLGEELEALRGE 1171

Query: 662  VKTSRSELNNLSE-----EYEV--LKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNT 714
            ++ +    N   E     E EV  LK+    ++   E    +L+ +   A  EL +    
Sbjct: 1172 LEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQ--- 1228

Query: 715  LKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKL 774
            L+      G   K  + ++ +++  R ++ +LQ+  Q  E+       +   ++      
Sbjct: 1229 LEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG 1288

Query: 775  SQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQES 834
             +  +  A +  +   ELE +       + K   +   L     Q  + Q+++Q  E+  
Sbjct: 1289 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ--EETR 1346

Query: 835  VRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVT-RSHSNVPSSQSTAS-FLSHHSTK 892
             +L L   +   E +  G      L+ +L + A+   R+   + ++Q+  S +      +
Sbjct: 1347 AKLALGSRVRAMEAEAAG------LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEE 1400

Query: 893  ANTL------KEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCIT 946
            A  L      +    R+ + L Q L      E   ++ + E   R     L+D   D   
Sbjct: 1401 AGALEAGEEARRRAAREAEALTQRLA-----EKTETVDRLERGRRRLQQELDDATMDLEQ 1455

Query: 947  ESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKN 1006
            +  L S +  +     +   E   +      E     A  RE  +   + T A     + 
Sbjct: 1456 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1515

Query: 1007 SASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTC 1066
                   +   ++ + +LL+S                        KD     +    + C
Sbjct: 1516 REELERQNRALRAELEALLSS------------------------KDDVGKSVHELERAC 1551

Query: 1067 RKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQEK 1109
            R  +     L+  V +L+ +  A        E  +Q +K Q +
Sbjct: 1552 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE 1594


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score =  130 bits (327), Expect = 7e-30
 Identities = 220/997 (22%), Positives = 410/997 (41%), Gaps = 125/997 (12%)

Query: 70   SPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAM 129
            S  ++  E  L E+S Q  + + ++   N+L  K +     ++ D++ +L++ +  R  +
Sbjct: 1056 SKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE----ATIADMEDRLRKEEKGRQEL 1111

Query: 130  ADIRRRESQSQEDLRNQL---QNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVL 186
              ++RR      +L+ Q+   Q    EL A    KE+ L+ +  + E            L
Sbjct: 1112 EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSL 1171

Query: 187  QEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQ 246
            +E ++ L + +E    +            R   +   K  R+L  E+  L+G +    D 
Sbjct: 1172 REAQAALAEAQEDLESE------------RVARTKAEKQRRDLGEELEALRGELEDTLDS 1219

Query: 247  LEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQE 306
              A + E ++K E  + + +  +E+    HE  +  L ++   A  +   +  Q+E    
Sbjct: 1220 TNA-QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE---LAEQLE---- 1271

Query: 307  QARNQNSMYMRQLSDLESTVSQLRSEL---REAKRMYEDKTEELEKQL------------ 351
            QAR     + +    LE+ VS+LR+EL   + A++  E +   LE QL            
Sbjct: 1272 QARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1331

Query: 352  --VLANSELTEARTERDQFS-------QESGNLDDQLQKLLADLHKREKELSLEKEQNKR 402
                A  +L  A+ E +  S        ++  L  +L    A LH  ++ L  E      
Sbjct: 1332 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA 1391

Query: 403  LWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALK---SECQGQMERQMAAIQGKNES 459
            L  R          LR +L+      +R    L+  +   SE + + E +  A++   E+
Sbjct: 1392 LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEA 1451

Query: 460  LEKVS----SLTAQLESTKEML-------RKVVEELTAKKMTLESSERTISDLTTSLQEK 508
              + +    +LT +L    E +       R++ +EL    M LE   + +S    +L++K
Sbjct: 1452 RRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVS----TLEKK 1507

Query: 509  ERAIEATNAE--ITKLRSRVDLKLQELQHLKNEGDHL---RNVQTECEALKLQMTEKDKV 563
            +R  +   AE     LR+  + +  E +  + E   L   R ++ E EA +    E ++ 
Sbjct: 1508 QRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEARE----ELERQ 1563

Query: 564  IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKI-LKDKKDAKIRE 622
               LR ++E +       G++   ++      E+  ND R ++ EL+  L   +DAK+R 
Sbjct: 1564 NRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR- 1622

Query: 623  LEARVSDLELEKVKLVN----AGSERLRAV----KDIKQERDQLLNEVKTSRSELNNLSE 674
            LE  V  L+ +  + +     AG ER R +    +D + ERD+   +   + +    L  
Sbjct: 1623 LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEG 1682

Query: 675  EYEVLKRNFRNKS---EEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMG 731
            E E LK    +     EE      K++ Q+K    E+E+TR + + +   +  + K   G
Sbjct: 1683 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKG 1742

Query: 732  MQKQI--------TAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVAT 783
            ++ ++         + R +  A Q + +  +E + N N  K  + EEK +L   L  +  
Sbjct: 1743 LEAEVLRLQEELAASDRARRQAQQDRDEMADE-VANGNLSKAAILEEKRQLEGRLGQLEE 1801

Query: 784  EKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTL 843
            E  +     E+L  + R+L  +V ++   L  A   F+         + ES R +L+   
Sbjct: 1802 ELEEEQSNSELLNDRYRKLLLQVESLTTEL-SAERSFS--------AKAESGRQQLER-- 1850

Query: 844  DIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRD 903
             I+EL+G     ++  + R     +       + S  + A       T+   L     R 
Sbjct: 1851 QIQELRGRLGEEDAGARARHKMTIAA------LESKLAQAEEQLEQETRERILSGKLVRR 1904

Query: 904  LKQLLQELRSVINEEPAVS--LSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNS 961
             ++ L+E+   + EE  V+  L    E G   +  L+ ++ +   E+S       R    
Sbjct: 1905 AEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRE 1964

Query: 962  LRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTS 998
            L D TE   S+E+++RE  TL    R  P    TFT+
Sbjct: 1965 LEDVTE---SAESMNREVTTLRNRLRRGP---LTFTT 1995



 Score =  102 bits (254), Expect = 2e-21
 Identities = 120/640 (18%), Positives = 269/640 (42%), Gaps = 47/640 (7%)

Query: 222  ISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDR---------IEQL 272
            + ++ ++   E+  L+GR+  +E++   L  + + + EL  +  + R         +E +
Sbjct: 922  VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 981

Query: 273  ISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLR-S 331
            +SE E  +    E+  S + Q    + Q  I + +A  +     RQ   LE   ++ +  
Sbjct: 982  VSELEARVG--EEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMK 1039

Query: 332  ELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREK 391
            +  E   + ED+  +L K+  L    L E  ++  +  ++  +L+    K  A +   E 
Sbjct: 1040 KFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMED 1099

Query: 392  ELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMA 451
             L  E++  + L           + L+R LD  + E+Q      +    E + Q+ R+  
Sbjct: 1100 RLRKEEKGRQEL-----------EKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEE 1148

Query: 452  AIQGKNESLEKVSSLTAQL----ESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQ- 506
             +Q      E      AQL       +  L +  E+L ++++    +E+   DL   L+ 
Sbjct: 1149 ELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEA 1208

Query: 507  ---EKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKV 563
               E E  +++TNA+  +LRS+ + ++ EL+    E   +       EA   ++ ++   
Sbjct: 1209 LRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIH------EAAVQELRQRHG- 1260

Query: 564  IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIREL 623
                 Q +  + + + Q  R  GA +  +  LE E+++ R EL  L+  + + + + R L
Sbjct: 1261 -----QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRL 1315

Query: 624  EARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNF 683
            E ++ +++        A +E    ++  + E + +   +  + S+   LS+E    +   
Sbjct: 1316 ELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQL 1375

Query: 684  RNKSEEMEMTTNK---LKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR 740
             +  E ++  T     L  ++++ ++E    R  L+    +   A +     Q Q++  R
Sbjct: 1376 HDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWR 1435

Query: 741  GQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQER 800
             + +     ++  EEA   A +E   L +  ++ ++ +  +   + ++  EL+       
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1495

Query: 801  RLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQ 840
            + ++ V+ +E    K     AE +  + R  +E  R + +
Sbjct: 1496 QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAE 1535



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 172/883 (19%), Positives = 334/883 (37%), Gaps = 122/883 (13%)

Query: 269  IEQLISEHEVEITGL------TEKASSARSQANSIQSQMEIIQEQARN-------QNSMY 315
            + QL  E ++++T +        +   AR      Q Q   ++   RN       ++  +
Sbjct: 833  LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQW 892

Query: 316  MRQLSDLESTVSQLRS-ELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGN 374
             R  + ++  +   R  E+ +A+     K +EL++Q   +  E+ E +    Q  +E   
Sbjct: 893  WRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQ---SAREVGELQGRVAQLEEERAR 949

Query: 375  LDDQLQKLLADLHKREKELSLEKEQNK-RLWDRDTGNSITIDHLRRELDNRNMEVQRLEA 433
            L +QL        + E EL  E E+ + RL  R     + +  L   +       ++++ 
Sbjct: 950  LAEQL--------RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 1001

Query: 434  LLKALKSECQGQMERQMAAIQGKNESL--EKVSSLTAQLESTKE---MLRKVVEELTAKK 488
              K L+   Q ++E  + A +G  + L  EKV++  A+++  +E   +L     +L+ ++
Sbjct: 1002 EKKRLQQHIQ-ELEAHLEAEEGARQKLQLEKVTT-EAKMKKFEEDLLLLEDQNSKLSKER 1059

Query: 489  MTLESSERTISDLTTSLQEKERAI-------EATNAEITKLRSRVDLKLQELQHLKNEGD 541
              LE      S      +EK +++       EAT A++     + +   QEL+ LK    
Sbjct: 1060 KLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLK---- 1115

Query: 542  HLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIND 601
              R +  E   L+ QM E+ +  E LR Q+          GR    +Q   A+ E E   
Sbjct: 1116 --RRLDGESSELQEQMVEQQQRAEELRAQL----------GRKEEELQAALARAEDEGGA 1163

Query: 602  RRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNE 661
            R   LK L+      +A+    EA+  DLE E+V    A  +R    +D+ +E + L  E
Sbjct: 1164 RAQLLKSLR------EAQAALAEAQ-EDLESERVARTKAEKQR----RDLGEELEALRGE 1212

Query: 662  VKTSRSELNNLSE-----EYEV--LKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNT 714
            ++ +    N   E     E EV  LK+    ++   E    +L+ +   A  EL +    
Sbjct: 1213 LEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQ--- 1269

Query: 715  LKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKL 774
            L+      G   K  + ++ +++  R ++ +LQ+  Q  E+       +   ++      
Sbjct: 1270 LEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG 1329

Query: 775  SQELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQES 834
             +  +  A +  +   ELE +       + K   +   L     Q  + Q+++Q  E+  
Sbjct: 1330 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ--EETR 1387

Query: 835  VRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVT-RSHSNVPSSQSTAS-FLSHHSTK 892
             +L L   +   E +  G      L+ +L + A+   R+   + ++Q+  S +      +
Sbjct: 1388 AKLALGSRVRAMEAEAAG------LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEE 1441

Query: 893  ANTL------KEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCIT 946
            A  L      +    R+ + L Q L      E   ++ + E   R     L+D   D   
Sbjct: 1442 AGALEAGEEARRRAAREAEALTQRLA-----EKTETVDRLERGRRRLQQELDDATMDLEQ 1496

Query: 947  ESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKN 1006
            +  L S +  +     +   E   +      E     A  RE  +   + T A     + 
Sbjct: 1497 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1556

Query: 1007 SASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTC 1066
                   +   ++ + +LL+S                        KD     +    + C
Sbjct: 1557 REELERQNRALRAELEALLSS------------------------KDDVGKSVHELERAC 1592

Query: 1067 RKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQEK 1109
            R  +     L+  V +L+ +  A        E  +Q +K Q +
Sbjct: 1593 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHE 1635


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  130 bits (326), Expect = 9e-30
 Identities = 217/1122 (19%), Positives = 476/1122 (42%), Gaps = 148/1122 (13%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQM-------- 124
            +E   ++  E   Q+K +++   E     +++   ++Q V+D+  K  E Q+        
Sbjct: 427  EEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE 486

Query: 125  ------ERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKM 178
                  E++    ++ RE + QE ++  L+ +  E       KE     +  ++E  +K 
Sbjct: 487  KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA 546

Query: 179  MLSH-EGVLQEI-------RSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELD 230
            +L+  E  L+++       R+ +++ E +  K + E+ + S      L +  +K  +E+ 
Sbjct: 547  ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT 606

Query: 231  TEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSA 290
              +   K  +  ++ Q +AL +E   K+++L QQ+Q  +E+L  + E       EK +  
Sbjct: 607  VMVEKHKTELESLKHQQDALWTE---KLQVLKQQYQTEMEKLREKCE------QEKETLL 657

Query: 291  RSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQL---RSELREAKRMYEDKTEEL 347
            + +    Q+ +E + E+   +  +   +L  L S +S++   R +L E   + +D+T+++
Sbjct: 658  KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717

Query: 348  EKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELS--------LEKEQ 399
            +++L        EA+ + +Q +     +D  +++    + + EK L         L KE+
Sbjct: 718  KQEL--------EAKMD-EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768

Query: 400  NKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNES 459
            +K L +    +   +++L  ++     E+Q+  A L   +S      E+  A      E 
Sbjct: 769  DKHLKE----HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKA----YEEQ 820

Query: 460  LEKVSSLTAQLESTKEMLRKVVEELTAKK----MTLESSERTISDLTTSLQEKERAIEAT 515
            L ++      LE+ + +L K V E+ A+K      L++ +  + DL   L+++   +E  
Sbjct: 821  LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME-- 878

Query: 516  NAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTE-KDKVIEILRQQI--- 571
                 K++S   +   +L+    E +  + +  E E + LQM E + K IEIL Q++   
Sbjct: 879  ----QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934

Query: 572  ENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLE 631
            E+   ++ +   T    Q +K +  K+      E  + K+L  +   K +ELE    +L 
Sbjct: 935  EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLK-KELENTALELS 993

Query: 632  ----------LEKVKLVNAG-SERLRAVKDIKQERDQLLNEVKTSRSELNN--------L 672
                      LE  +  +AG S+ +  ++  ++E+ + L EV   R ELN+        L
Sbjct: 994  QKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV--HRRELNDVISIWEKKL 1051

Query: 673  SEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGM 732
            +++ E L+     + +E E    +LK ++     E E+    +  ++            +
Sbjct: 1052 NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111

Query: 733  QKQITAKRGQIDA-------LQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEK 785
            Q+Q+  K   +++       L++ ++ LE  +  + KE  FL+E+  +L         + 
Sbjct: 1112 QEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171

Query: 786  NKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDI 845
            +++  +L+    + + LK        +L+  SL+F          ++ S  L +Q  +  
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF----------KKLSEELAIQLDICC 1221

Query: 846  KELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLK 905
            K+       + + L+ +  +  +++ S +N  +  S  S   H +TK        T  + 
Sbjct: 1222 KK-------TEALLEAKTNELINISSSKTN--AILSRISHCQHRTTKVKEALLIKTCTVS 1272

Query: 906  QLLQELRSVINEEPAVSLSKTE-----EDGRTSLGALEDRVRDCITESSLRSDMCHRSNN 960
            +L  +LR +  E+  +++S  +     E+    + +++  +   +TE   +  +     N
Sbjct: 1273 ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE---KEALQKEGGN 1329

Query: 961  SLRDSTEGSKSSETLSRE------PVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNS 1014
              + ++E       L +E       VTL   + ++     +  S     +      S + 
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389

Query: 1015 SPKKSPVHSLLTSSVEGSIGSTSQYR---------SAKPIHSSDSVKDSQSPPIETTGKT 1065
            S K++ + SL     E       Q +         S + I + + V D  +   E     
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK--- 1446

Query: 1066 CRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
             +K Q+R    Q  V++LQ++ +  S     ++++I  +K++
Sbjct: 1447 -KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEE 1487



 Score =  104 bits (260), Expect = 4e-22
 Identities = 172/916 (18%), Positives = 385/916 (42%), Gaps = 109/916 (11%)

Query: 111  SVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNT 170
            +V +L+ +L+++  E++ +    ++ +   E+  NQ+++   ++E+    KE + K+   
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329

Query: 171  Q----------IEQLRKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMS--------- 211
            Q          I QL+K +       + I ++ +  EE   KK+ E  S+S         
Sbjct: 1330 QQQAASEKESCITQLKKELS------ENINAVTLMKEELKEKKV-EISSLSKQLTDLNVQ 1382

Query: 212  ---TLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELL------L 262
               ++      +AIS + ++ D E   L  ++  +  +++ L  E  + +E +       
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442

Query: 263  QQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMY---MRQL 319
             + + + +   ++H+  +  L  +      +A     Q+ +++E+   QN  +     ++
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502

Query: 320  SDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQL 379
             D +S + +  S L    +    +  ELE  +     E+         ++Q+      +L
Sbjct: 1503 EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562

Query: 380  QKLLADLHK--REKELSLEKEQNKRLWDRDTGNSIT--IDHLRRELDNRNMEVQRLEALL 435
             + L    +   EK+  +++ + K L   +   S+   ++  ++EL++ N+ V+  E  L
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEEL 1622

Query: 436  KALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSE 495
            KAL+   + +   ++A ++ K E  +K++++  QL S  E      +E   KK T    E
Sbjct: 1623 KALEDRLESESAAKLAELKRKAE--QKIAAIKKQLLSQMEE-----KEEQYKKGT----E 1671

Query: 496  RTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKL 555
              +S+L T LQE+ER +     ++  + S     L   +  KN   +    + + +   +
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC-V 1730

Query: 556  QMTEKDKVIEILRQ--QIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILK 613
            Q T ++K+  + R   + E + Q VGQ          EK +      + R + +E  I  
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQ----------EKEETVSSHFEMRCQYQERLIKL 1780

Query: 614  DKKDAKIRELEARVSDLELE------KVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRS 667
            +  +AK  E ++ +  L+ E      K  L+ A        K+  Q +  L N     + 
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840

Query: 668  ELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMK 727
             L    +E E+  +    K +E++    + K   +    EL      L++++  DG    
Sbjct: 1841 TL----QEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKP 1896

Query: 728  VAMGMQKQITAKRGQIDALQSKIQFLEEAMTN--------ANKEKHFLKEEKSKLSQELS 779
              +   ++ T ++ +   +Q K+    EA  N        A +EK  L +E  +L ++L 
Sbjct: 1897 TEL--LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954

Query: 780  TVATEKNKMAGELEVLRSQ-----ERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQES 834
             +  E  +   ELE+L+ +     E ++K++  ++E+  +    Q     +    Q+++ 
Sbjct: 1955 MLRKEHQQ---ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011

Query: 835  VRLKLQHTLD-IKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKA 893
            + + ++ T++  +E++     S+     +LL+   +     ++  +      +     + 
Sbjct: 2012 LEMTIKETINKAQEVEAELLESHQEETNQLLK--KIAEKDDDLKRTAKRYEEILDAREEE 2069

Query: 894  NTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVR-----DCITES 948
             T K    RDL+  L+EL+    ++    L + E  G  ++  +E + +       I++S
Sbjct: 2070 MTAK---VRDLQTQLEELQKKYQQK----LEQEENPGNDNVTIMELQTQLAQKTTLISDS 2122

Query: 949  SLRSDMCHRSNNSLRD 964
             L+        ++L D
Sbjct: 2123 KLKEQEFREQIHNLED 2138



 Score =  103 bits (257), Expect = 9e-22
 Identities = 163/867 (18%), Positives = 357/867 (41%), Gaps = 125/867 (14%)

Query: 56   KYEVELDSPRKI---IPSPGKEHFERVLEEYSHQVKDLQRRL-NESNELHEKQKFYLRQ- 110
            +YE +  +  K    +    KE  E + ++   Q   L++ L N + EL +K+K +  + 
Sbjct: 944  EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003

Query: 111  ---------SVIDLQTKLQEMQMER-DAMADIRRRE------------SQSQEDLRN--- 145
                      + D  ++L+  Q E+ +++ ++ RRE            +Q  E+L+    
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063

Query: 146  -QLQNTVHELEAAK-------CLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFE 197
             QLQ    E+   K       C KE+M    N +I  L++  +  +  L E++  L   +
Sbjct: 1064 IQLQEKEQEVAELKQKILLFGCEKEEM----NKEITWLKEEGVKQDTTLNELQEQLKQ-K 1118

Query: 198  EASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNK 257
             A    + + ++    H   L   ++K L+E     ++L+ ++     +L+ L  E + K
Sbjct: 1119 SAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN----TFLQEQLV----ELKMLAEEDKRK 1170

Query: 258  IELL---LQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSM 314
            +  L   L+   +  + L S HE     L +K+   +  +  +  Q++I     +   ++
Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDIC---CKKTEAL 1227

Query: 315  YMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGN 374
               + ++L +  S   + +       + +T ++++ L++    ++E   +  Q ++E   
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287

Query: 375  LDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEAL 434
            L+   Q+    L ++E ++   K   + L           + L++E  N+       E+ 
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEK-------EALQKEGGNQQQAASEKESC 1340

Query: 435  LKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESS 494
            +  LK E    +       +   E   ++SSL+ QL      L+  +  L+ K+  + S 
Sbjct: 1341 ITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS-LSEKEAAISSL 1399

Query: 495  ERTISD----LTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDH-------- 542
             +   +    L   +Q+    ++  + E      +VD    +    K +           
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459

Query: 543  LRNVQTECEALKLQMTEKDKVIEILRQQIENMTQ----LVGQHGRTAGAMQVEKAQLEKE 598
            ++ +Q + E    +  EKD+ I +L+++++   +    L G+       M+ +++ LE E
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519

Query: 599  INDRRMELKELKILKDKKDAKIRELEARVSDL----ELEKVKLVNA-------GSERLRA 647
            +  +   + EL+    +K  +I  L   + +     ++E  +LV         G E+   
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579

Query: 648  VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSE 707
            VK+ +++   L N+V + ++EL    +E E +  + ++K EE++   ++L+ +  +  +E
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639

Query: 708  LEQ---------TRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMT 758
            L++          +  L  ME  +    K   G +  ++    ++   + ++  LEE   
Sbjct: 1640 LKRKAEQKIAAIKKQLLSQMEEKEEQYKK---GTESHLSELNTKLQEREREVHILEEK-- 1694

Query: 759  NANKEKHFLKEEKSKLSQELSTVATEKNKMA-GELEVLRSQ---ERRLKEKVTNMEVALD 814
                    LK  +S  S+ L    + KN  A  E E   SQ   ++  +EK++ ++  L 
Sbjct: 1695 --------LKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNL- 1745

Query: 815  KASLQFAECQDIIQRQEQESVRLKLQH 841
                   E + ++QR  QE       H
Sbjct: 1746 ------TEKEKLLQRVGQEKEETVSSH 1766



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 165/769 (21%), Positives = 330/769 (42%), Gaps = 122/769 (15%)

Query: 86   QVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQ---EMQMERDAMADIRRRESQSQED 142
            QV D   + +E  +  + +    + +V +LQ +L+   +   E+D   ++ + E   Q  
Sbjct: 1434 QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNK 1493

Query: 143  ----LRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEE 198
                L+ ++++   ++E  +   E  LK    +I +L   +      ++ +  +L ++ +
Sbjct: 1494 RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ 1553

Query: 199  ASGKKICEHDSM--STLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQN 256
               +K  EH  +     HF+ LG      ++E + +I  L+ +++ ++ +LE  K E ++
Sbjct: 1554 ---QKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEH 1610

Query: 257  KIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYM 316
             + L ++  ++ ++ L  E  +E     + A   R     I +  + +  Q   +   Y 
Sbjct: 1611 -VNLSVKSKEEELKAL--EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK 1667

Query: 317  RQLSDLESTVSQLRSELREAKR---MYEDKTEELEKQ-----LVLANSELTEARTERDQF 368
            +     ES +S+L ++L+E +R   + E+K + +E       +V  +++   A TE+++ 
Sbjct: 1668 K---GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEA 1724

Query: 369  SQES---GNLDDQLQKLLADLHKREKELSL---EKEQN------------------KRLW 404
              +       ++++  L  +L ++EK L     EKE+                   +   
Sbjct: 1725 DSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAE 1784

Query: 405  DRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVS 464
             +   +   I HL+ EL+ +N +     +L+ A   E +G          GKN    K +
Sbjct: 1785 AKQHEDQSMIGHLQEELEEKNKKY----SLIVAQHVEKEG----------GKNNIQAKQN 1830

Query: 465  SLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRS 524
                 LE+  + ++K ++E   K++T +  E+ I +L + L  ++   E    E+ +L S
Sbjct: 1831 -----LENVFDDVQKTLQE---KELTCQILEQKIKELDSCLVRQK---EVHRVEMEELTS 1879

Query: 525  RVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHG-- 582
            + + KLQ LQ +       RN  TE   L+    EK K   +  + + NM     QH   
Sbjct: 1880 KYE-KLQALQQMDG-----RNKPTEL--LEENTEEKSKSHLVQPKLLSNME---AQHNDL 1928

Query: 583  --RTAGAMQVEKAQLEKEI----NDRRMELKE----LKILKDKKDAKIRE-LEARVSDLE 631
              + AGA + EK +L KEI     D RM  KE    L+ILK + D +  E ++    DLE
Sbjct: 1929 EFKLAGAER-EKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLE 1987

Query: 632  LE------------KVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSE-----LNNLSE 674
            L+              +L     E    +K+   +  ++  E+  S  E     L  ++E
Sbjct: 1988 LKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAE 2047

Query: 675  EYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLK---SMEGSDGHAMKVAMG 731
            + + LKR  +   E ++    ++  +++  Q++LE+ +   +     E + G+     M 
Sbjct: 2048 KDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIME 2107

Query: 732  MQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELST 780
            +Q Q+  K   I   + K Q   E + N   E    K EK+  +  + T
Sbjct: 2108 LQTQLAQKTTLISDSKLKEQEFREQIHNL--EDRLKKYEKNVYATTVGT 2154



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 202/1067 (18%), Positives = 440/1067 (41%), Gaps = 172/1067 (16%)

Query: 108  LRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKD 167
            L+Q + + Q +LQ+      A ++     S +   +R++  +   +L+     +E    D
Sbjct: 5    LKQKISEEQQQLQQALAPAQASSN-----SSTPTRMRSRTSSFTEQLDEGTPNRES--GD 57

Query: 168  SNTQIEQLRKMMLSHEGVLQE-IRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKI- 225
            + +  ++L+  + S E + +  I+  L  F  +S + +    S  +L+   L S+ +   
Sbjct: 58   TQSFAQKLQLRVPSVESLFRSPIKESL--FRSSSKESLVRTSSRESLNRLDLDSSTASFD 115

Query: 226  -LRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLT 284
               ++D+E   L G             S+S NK +L+  Q   R+E+ +S +        
Sbjct: 116  PPSDMDSEAEDLVGN------------SDSLNKEQLI--QRLRRMERSLSSY-------- 153

Query: 285  EKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKT 344
                  R + + + +  +++Q + +    +  +        +++LR EL+  ++  +   
Sbjct: 154  ------RGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQ 207

Query: 345  EELEKQLVLANSELTEARTERDQFSQE--SGNLDDQLQKLLADLHKREKELSLEKEQNKR 402
            EE +  L   +  ++  +T+     Q   +G ++  + K L  L  + +  +  KE+N  
Sbjct: 208  EEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFT--KEENPE 265

Query: 403  LWDRDTGNSITIDHLR-RELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLE 461
                  G  +  D    + L+     V+R E LLK  K   Q   E+       K    E
Sbjct: 266  ----SDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQE 321

Query: 462  KVSSLTAQLESTKEM----LRKVVEELTAKKMTLESSERTISD-LTTSLQEKERAIEATN 516
            ++     +LE  K++      K++ +L   K  +E  E+     +  + ++    +E   
Sbjct: 322  QLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKE 381

Query: 517  AEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEK-----DKVIEILRQQI 571
             EI +LRSR+       + +  +G+ LR  + + E    +  EK      K  E  R+  
Sbjct: 382  EEIAQLRSRI-------KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK 434

Query: 572  ENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLE 631
              M + +    +T+   + E+  L++E++  R++ + + ++K   + +I +L+      +
Sbjct: 435  AEMDEQIKTIEKTS---EEERISLQQELS--RVKQEVVDVMKKSSEEQIAKLQ------K 483

Query: 632  LEKVKLVNAGSERLRAVKDIKQE-RDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEM 690
            L + +L     E  + ++  ++E ++Q+   ++ S+SE   +S+E          K ++ 
Sbjct: 484  LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE----------KEQQE 533

Query: 691  EMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKI 750
             +   +L++Q K+  +E E   N L+ +              Q++    R +I  L+S +
Sbjct: 534  SLALEELELQKKAILTESE---NKLRDL--------------QQEAETYRTRILELESSL 576

Query: 751  QFLEEAMTNANKEKHF---LKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRL----- 802
            +  +    N N+ K     L+ EK+K ++E+ TV  EK+K   ELE L+ Q+  L     
Sbjct: 577  E--KSLQENKNQSKDLAVHLEAEKNKHNKEI-TVMVEKHKT--ELESLKHQQDALWTEKL 631

Query: 803  ----KEKVTNMEVALDKASLQ---FAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTS 855
                ++  T ME   +K   +     + ++II +   E +  K    LD+K+ +    +S
Sbjct: 632  QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSS 691

Query: 856  NSS--LKPR--LLQPASVTRSHSNVPSSQSTASF---LSHHSTKANTLKEDPTRDLKQLL 908
              S  LK R  L +  SV +  ++    +  A      +HH  + +++ ++    +++  
Sbjct: 692  ELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE 751

Query: 909  QELRSVINE-------------EPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMC 955
            + L+  IN+             E    +   E D + S G L+        ++S + D+ 
Sbjct: 752  KALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ--------QASAKLDVF 803

Query: 956  HRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSS 1015
                ++  + T+  +      ++ +     D E      T   A   + K       ++ 
Sbjct: 804  QSYQSATHEQTKAYEEQLAQLQQKLL----DLETERILLTKQVAEVEAQKKDVCTELDAH 859

Query: 1016 PKKSPVHSLL------TSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKL 1069
              K  V  L+       S +E  + S +Q   +K    +   + ++   +E      +  
Sbjct: 860  --KIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMR 917

Query: 1070 QNRLESLQTLVEDLQLK-------NQAMSSMIRNQEKRIQKVKDQEK 1109
            + + + ++ L + L  K       N+   +  +NQEK+++KVK + K
Sbjct: 918  EGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 103/544 (18%), Positives = 223/544 (40%), Gaps = 89/544 (16%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E+Y    +     LN   +  E++   L + +  +++   E  +   +  ++     Q +
Sbjct: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE 1723

Query: 141  EDLRNQLQNTVHE----LEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDF 196
             D +  +Q T  E    L+     KE +L+    + E+    + SH  +  + +  L+  
Sbjct: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEET---VSSHFEMRCQYQERLIKL 1780

Query: 197  EEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYL----------------KGRI 240
            E A  K   +H+  S +        + + L E + + S +                K  +
Sbjct: 1781 EHAEAK---QHEDQSMI------GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNL 1831

Query: 241  FPVEDQLEALKSESQNKIELLLQQHQDRIEQLISE---HEVEITGLTEKASS--ARSQAN 295
              V D ++    E +   ++L Q+ ++    L+ +   H VE+  LT K     A  Q +
Sbjct: 1832 ENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMD 1891

Query: 296  SIQSQMEIIQEQARNQNSMYMRQ---LSDLESTVSQLRSELREAKRMYEDKTEELEKQLV 352
                  E+++E    ++  ++ Q   LS++E+  + L  +L  A+R    + ++L K++V
Sbjct: 1892 GRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER----EKQKLGKEIV 1947

Query: 353  LANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSI 412
                +L   R E  Q  +           +L   + +E+E  +++EQ     D +  ++ 
Sbjct: 1948 RLQKDLRMLRKEHQQELE-----------ILKKEYDQEREEKIKQEQE----DLELKHNS 1992

Query: 413  TIDHLRRELDNR-NMEVQRLEALLKALKSECQGQMERQMAAIQGK-NESLEKVSSLTAQL 470
            T+  L RE + +   + Q LE  +K   ++ Q      + + Q + N+ L+K++     L
Sbjct: 1993 TLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDL 2052

Query: 471  ESTKEMLRKVV----EELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRV 526
            + T +   +++    EE+TAK          + DL T L+E              L+ + 
Sbjct: 2053 KRTAKRYEEILDAREEEMTAK----------VRDLQTQLEE--------------LQKKY 2088

Query: 527  DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAG 586
              KL++ ++  N+   +  +QT+       +++     +  R+QI N+   + ++ +   
Sbjct: 2089 QQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVY 2148

Query: 587  AMQV 590
            A  V
Sbjct: 2149 ATTV 2152



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 65/339 (19%), Positives = 152/339 (44%), Gaps = 69/339 (20%)

Query: 77   ERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMER---------D 127
            ++ L+E     + L++++ E +    +QK   R  + +L +K +++Q  +         +
Sbjct: 1839 QKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898

Query: 128  AMADIRRRESQS---QEDLRNQLQNTVHELE----AAKCLKEDMLKDSNTQIEQLRKMML 180
             + +    +S+S   Q  L + ++   ++LE     A+  K+ + K+     + LR +  
Sbjct: 1899 LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958

Query: 181  SHEGVLQEIRSILVDFEEASGKKIC-EHDSMSTLHFRSLGSAISKILRELDTEISYLKGR 239
             H+   QE+  +  ++++   +KI  E + +   H     S + +++RE +T+++     
Sbjct: 1959 EHQ---QELEILKKEYDQEREEKIKQEQEDLELKH----NSTLKQLMREFNTQLAQK--- 2008

Query: 240  IFPVEDQLEALKSESQNKIEL----LLQQHQDRIEQLISEHEVEITGLTEKASSARSQAN 295
                E +LE    E+ NK +     LL+ HQ+   QL+ +       + EK    +  A 
Sbjct: 2009 ----EQELEMTIKETINKAQEVEAELLESHQEETNQLLKK-------IAEKDDDLKRTAK 2057

Query: 296  SIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTE---------- 345
              +  ++  +E+              + + V  L+++L E ++ Y+ K E          
Sbjct: 2058 RYEEILDAREEE--------------MTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNV 2103

Query: 346  ---ELEKQLVLANSELTEARTERDQFSQESGNLDDQLQK 381
               EL+ QL    + +++++ +  +F ++  NL+D+L+K
Sbjct: 2104 TIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 25/116 (21%), Positives = 57/116 (49%), Gaps = 8/116 (6%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADI 132
            +E   ++L++ + +  DL+R      E+ + ++  +   V DLQT+L+E+Q         
Sbjct: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK-------- 2086

Query: 133  RRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQE 188
            + ++   QE+       T+ EL+     K  ++ DS  + ++ R+ + + E  L++
Sbjct: 2087 KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  129 bits (325), Expect = 1e-29
 Identities = 196/957 (20%), Positives = 402/957 (42%), Gaps = 110/957 (11%)

Query: 81   EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ 140
            E +   + DLQ   ++ N L  K K  L Q V DL+  L++   E+    D+ R + + +
Sbjct: 1004 ETHQQTLDDLQAEEDKVNIL-TKAKTKLEQQVDDLEGSLEQ---EKKLRMDLERAKRKLE 1059

Query: 141  EDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFE--- 197
             DL+   ++T+ ++E  K   ++ L+    +I  L   +   + V  +++  + + +   
Sbjct: 1060 GDLKLAQESTM-DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARI 1118

Query: 198  EASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNK 257
            E  G++I E +  S        S +S+ L E+   +    G          + + E   K
Sbjct: 1119 EELGEEI-EAERASRAKAEKQRSDLSRELEEISERLEEAGG--------ATSAQVELNKK 1169

Query: 258  IELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMR 317
             E   Q+ +  +E+   +HE  +  L +K + + ++       ++ ++++   + S    
Sbjct: 1170 REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKM 1229

Query: 318  QLSDLES---TVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGN 374
            +  DL S    +S+ +  L +  R  ED+  EL+ +       + +   +R +   E+G 
Sbjct: 1230 ETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGE 1289

Query: 375  LDDQLQK---LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH-----------LRRE 420
               QL +   L++ L + ++  + + E+ K   + +T     + H           LR +
Sbjct: 1290 YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQ 1349

Query: 421  LDNR---NMEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEML 477
             +       E+QR  AL KA     Q + + +  AIQ   E  E    L  +L+  +E +
Sbjct: 1350 YEEEQEGKAELQR--ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHV 1407

Query: 478  RKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAE---ITKLRSRVDLKLQELQ 534
              V  +  + + T +  +  + DL   ++    A  A + +     K+ S    K +E Q
Sbjct: 1408 EAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQ 1467

Query: 535  -HLKNEGDHLRNVQTECEALKLQMTEKDKVIEILR-------QQIENMTQLVGQHGRTAG 586
              L+      R++ TE   +K    E    +E LR       Q+I ++T+ + + G+   
Sbjct: 1468 AELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH 1527

Query: 587  AMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLR 646
             ++  K Q+E+E  + +  L+E +   + ++ KI  ++     LEL +VK     SE  R
Sbjct: 1528 ELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ-----LELNQVK-----SEVDR 1577

Query: 647  AVKDIKQERDQLLNE----VKTSRSELNNLSEEYEVLKRNFRNK-SEEMEMTTNKLKMQL 701
             + +  +E DQL       V+T +S L     + E+  RN   +  ++ME   N++++QL
Sbjct: 1578 KIAEKDEEIDQLKRNHTRVVETMQSTL-----DAEIRSRNDALRVKKKMEGDLNEMEIQL 1632

Query: 702  ----KSAQSELEQTRNTLKSMEGSDGH---AMKVAMGMQKQITAKRGQIDALQSKIQFLE 754
                + A   L   RNT   ++ +  H   A++    +++Q+     + + LQ++I+ L 
Sbjct: 1633 NHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELW 1692

Query: 755  EAMTNANKEKHFLKEEKSKLSQELSTVATE-------KNKMAGELEVLRSQERRLKEKVT 807
              +    + +   ++E    S+ +  + T+       K K+  ++  L+S+   + ++  
Sbjct: 1693 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESR 1752

Query: 808  NMEVALDKASLQFAECQDIIQRQEQESVRLK------------LQHTLDIKE---LQGPG 852
            N E    KA    A   + +++++  S  L+            LQH LD  E   L+G G
Sbjct: 1753 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKG-G 1811

Query: 853  YTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELR 912
                  L+ R+ +      +      +      L  H  +   L      D K +L+ L+
Sbjct: 1812 KKQIQKLEARVRELEGEVENEQK--RNAEAVKGLRKHERRVKELTYQTEEDRKNVLR-LQ 1868

Query: 913  SVINEEPAVSLS------KTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLR 963
             ++++  A   S      + EE    +L     +++  + E+  R+D+     N LR
Sbjct: 1869 DLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR-KLQHELEEAEERADIAESQVNKLR 1924



 Score =  124 bits (312), Expect = 4e-28
 Identities = 218/1069 (20%), Positives = 429/1069 (40%), Gaps = 138/1069 (12%)

Query: 114  DLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLKDSNTQIE 173
            ++ T  +E Q  +D +A    +  + +E +   L+   ++L+     + D L D+  + E
Sbjct: 851  EMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEK-NDLQLQVQSEADSLADAEERCE 909

Query: 174  QLRKMMLSHEGVLQEIRSILVDFEE------ASGKKICEHDSMSTLHFRSLGSAISKILR 227
            QL K  +  E  ++E+     + EE      A  +K+ +  S        L   ++K+ +
Sbjct: 910  QLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 969

Query: 228  E----------LDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLIS--- 274
            E          L  E++ L   I  +  + +AL+   Q  ++ L Q  +D++  L     
Sbjct: 970  EKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL-QAEEDKVNILTKAKT 1028

Query: 275  --EHEVE-ITGLTEKASSARSQAN----SIQSQMEIIQEQA---RNQNSMYMRQLSDLES 324
              E +V+ + G  E+    R         ++  +++ QE      N       +L   E 
Sbjct: 1029 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEF 1088

Query: 325  TVSQLRSELREAKRM---YEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQK 381
             +S L S++ + + +    + K +EL+ ++     E+   R  R +  ++  +L  +L++
Sbjct: 1089 EISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE 1148

Query: 382  LLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSE 441
            +   L +     S + E NK+              LRR+L+   ++ + + A L+   ++
Sbjct: 1149 ISERLEEAGGATSAQVELNKK-------REAEFQKLRRDLEEATLQHEAMVAALRKKHAD 1201

Query: 442  CQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDL 501
               ++  Q+  +Q   + LEK  S   +L+   + L    E ++  K  LE   R++ D 
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKS---ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQ 1258

Query: 502  TTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL-----RNVQT---ECEAL 553
             + L+ KE   +    ++T  R+R+  +  E     +E D L     R+ Q    + E L
Sbjct: 1259 VSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEEL 1318

Query: 554  KLQMTEKDKV--------------IEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE-KE 598
            K Q+ E+ K                ++LR+Q E   +   +  R       E AQ   K 
Sbjct: 1319 KHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY 1378

Query: 599  INDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKD-IKQERDQ 657
              D     +EL+  K K   +++E E        E V+ VNA    L   K  ++ E + 
Sbjct: 1379 ETDAIQRTEELEEAKKKLAQRLQEAE--------EHVEAVNAKCASLEKTKQRLQNEVED 1430

Query: 658  LLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKS 717
            L+ +V+ S +    L ++    +RNF       +   ++ K + +  Q+ELE ++   +S
Sbjct: 1431 LMLDVERSNAACAALDKK----QRNF-------DKVLSEWKQKYEETQAELEASQKESRS 1479

Query: 718  MEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQE 777
            +         V      Q+   R +   LQ +I  L E +    K+ H L++ K ++ QE
Sbjct: 1480 LSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQE 1539

Query: 778  LSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRL 837
               +     +    LE    +  R++ ++  ++  +D+   +  E  D ++R     V  
Sbjct: 1540 KCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVET 1599

Query: 838  KLQHTLDIKELQGPGYTSNSSLKPRL-----LQPASVTRSHSNVPSSQSTASFLSHHSTK 892
             +Q TLD  E++    + N +L+ +      L    +  +H+N  +++S  ++ +     
Sbjct: 1600 -MQSTLDA-EIR----SRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGIL 1653

Query: 893  ANTLK--EDPTR---DLKQLLQ--ELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCI 945
              T    +D  R   DLK+ L   E R+ + +     L  T E    S    E  + D  
Sbjct: 1654 KETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLD-- 1711

Query: 946  TESSLRSDMCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVK 1005
              +S R  + H  N SL ++ +  K    +S+    +    +E                 
Sbjct: 1712 --ASERVQLLHTQNTSLINTKK--KLENDVSQLQSEVEEVIQE----------------- 1750

Query: 1006 NSASRSFNSSPKKSPVHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTG-- 1063
               SR+     KK+   + + +        TS +      +   +VKD Q    E     
Sbjct: 1751 ---SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807

Query: 1064 -----KTCRKLQNRLESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQ 1107
                 K  +KL+ R+  L+  VE+ Q +N      +R  E+R++++  Q
Sbjct: 1808 LKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQ 1856



 Score =  101 bits (252), Expect = 3e-21
 Identities = 160/813 (19%), Positives = 337/813 (41%), Gaps = 111/813 (13%)

Query: 228  ELDTEISYLKGRIFPVEDQL---EALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLT 284
            E + E++ +K      +D+L   EA + E + K+  LL++  D   Q+ SE +  +    
Sbjct: 847  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEAD-SLADAE 905

Query: 285  EKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKT 344
            E+          ++++++ + E+A  +                ++ +EL   KR  ED+ 
Sbjct: 906  ERCEQLIKNKIQLEAKIKEVTERAEEEE---------------EINAELTAKKRKLEDEC 950

Query: 345  EELEKQLVLANSELTEARTERDQFSQESG--NLDDQLQKLLADLHKREKELSLEKEQNKR 402
             EL+K +   + ELT A+ E+++ + E+   NL +++  L   + K  KE    +E +++
Sbjct: 951  SELKKDI--DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ 1008

Query: 403  LWD-----RDTGNSIT---------IDHLRRELDNRN---MEVQRLEALLKA---LKSEC 442
              D      D  N +T         +D L   L+      M+++R +  L+    L  E 
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1068

Query: 443  QGQMERQMAAIQGKNESLE-KVSSLTAQLESTKEM--------------LRKVVEELTAK 487
               ME     +  K E  E ++S+L +++E  + +              + ++ EE+ A+
Sbjct: 1069 TMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE 1128

Query: 488  KMTLESSERTISDLTTSLQEKERAIE----ATNAEITKLRSRVDLKLQELQHLKNEGDHL 543
            + +   +E+  SDL+  L+E    +E    AT+A++ +L  + + + Q+L+    E    
Sbjct: 1129 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV-ELNKKREAEFQKLRRDLEEA--- 1184

Query: 544  RNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRR 603
              +Q E     L+    D + E L +QI+N+ ++              K +LEKE ++ +
Sbjct: 1185 -TLQHEAMVAALRKKHADSMAE-LGEQIDNLQRV--------------KQKLEKEKSELK 1228

Query: 604  MELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVK 663
            ME  +L    +        LE     LE +  +L     E+ R + D+  +R +L  E  
Sbjct: 1229 METDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAG 1288

Query: 664  TSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQS---ELEQTRNTLKSMEG 720
                +L+        L R+ +  ++++E   ++L+ + K+  +    L+ +R+    +  
Sbjct: 1289 EYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLRE 1348

Query: 721  SDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELST 780
                  +    +Q+ ++    ++   ++K +      T+A +    L+E K KL+Q L  
Sbjct: 1349 QYEEEQEGKAELQRALSKANSEVAQWRTKYE------TDAIQRTEELEEAKKKLAQRLQE 1402

Query: 781  VATEKNKMAGELEVLRSQERRLKEKVTNMEV----------ALDKASLQFAE-CQDIIQR 829
                   +  +   L   ++RL+ +V ++ +          ALDK    F +   +  Q+
Sbjct: 1403 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQK 1462

Query: 830  QEQESVRLKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHH 889
             E+    L+     + + L    +   +  +  L Q  ++ R + N+   Q   S L+  
Sbjct: 1463 YEETQAELEASQK-ESRSLSTELFKVKNVYEESLDQLETLRRENKNL---QQEISDLTEQ 1518

Query: 890  STKANTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGR-----TSLGALEDRVRDC 944
              +      +  +  KQ+ QE   +         S   E+G+       L  ++  V   
Sbjct: 1519 IAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1578

Query: 945  ITESSLRSDMCHRSNNSLRDSTEGSKSSETLSR 977
            I E     D   R++  + ++ + +  +E  SR
Sbjct: 1579 IAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSR 1611



 Score =  101 bits (251), Expect = 4e-21
 Identities = 137/691 (19%), Positives = 300/691 (43%), Gaps = 107/691 (15%)

Query: 56   KYEVELDSPRKIIPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDL 115
            +Y  +LD    ++         R  +  + Q+++L+ +L E  +        L+ S  D 
Sbjct: 1289 EYSRQLDEKDALV-----SQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDC 1343

Query: 116  QTKLQEMQMERDAMADIRRRESQSQEDLR--------NQLQNTVHELEAAKCLKEDMLKD 167
                ++ + E++  A+++R  S++  ++         + +Q T  ELE AK      L++
Sbjct: 1344 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQE 1402

Query: 168  SNTQIEQLRKMMLSHEGVLQ----EIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAIS 223
            +   +E +     S E   Q    E+  +++D E ++    C              +A+ 
Sbjct: 1403 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA--C--------------AALD 1446

Query: 224  KILRELDTEISYLKGRIFPVEDQLEALKSESQN------KIELLLQQHQDRIEQLISEH- 276
            K  R  D  +S  K +    + +LEA + ES++      K++ + ++  D++E L  E+ 
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENK 1506

Query: 277  --EVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELR 334
              + EI+ LTE+ +    Q +    ++E I++Q   +       L + E+++     ++ 
Sbjct: 1507 NLQQEISDLTEQIAEGGKQIH----ELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL 1562

Query: 335  EAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLL-ADLHKREKEL 393
              +        E+++++   + E+       DQ  +    + + +Q  L A++  R   L
Sbjct: 1563 RIQLELNQVKSEVDRKIAEKDEEI-------DQLKRNHTRVVETMQSTLDAEIRSRNDAL 1615

Query: 394  SLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKA----LKSECQGQ--ME 447
             ++K+    L + +    I ++H  R         +  + +LK     L    +GQ  ++
Sbjct: 1616 RVKKKMEGDLNEME----IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLK 1671

Query: 448  RQMAAIQGKNESLE-KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERT--ISDLTTS 504
             Q+A ++ +   L+ ++  L A LE T E  RK+ E+       L++SER   +    TS
Sbjct: 1672 EQLAIVERRANLLQAEIEELWATLEQT-ERSRKIAEQ-----ELLDASERVQLLHTQNTS 1725

Query: 505  LQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVI 564
            L   ++ +E    ++++L+S V+  +QE ++ +             E  K  +T+   + 
Sbjct: 1726 LINTKKKLEN---DVSQLQSEVEEVIQESRNAE-------------EKAKKAITDAAMMA 1769

Query: 565  EILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKK-----DAK 619
            E L+++ +    L          M+    Q  K++  R  E ++L +   KK     +A+
Sbjct: 1770 EELKKEQDTSAHLE--------RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR 1821

Query: 620  IRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVL 679
            +RELE  V + +    + V    +  R VK++  + +    E + +   L +L ++ +  
Sbjct: 1822 VRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTE----EDRKNVLRLQDLVDKLQAK 1877

Query: 680  KRNFRNKSEEMEMTTNKLKMQLKSAQSELEQ 710
             ++++ ++EE E  +N    + +  Q ELE+
Sbjct: 1878 VKSYKRQAEEAEEQSNANLSKFRKLQHELEE 1908



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 101/528 (19%), Positives = 210/528 (39%), Gaps = 42/528 (7%)

Query: 590  VEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVK 649
            ++ A+ EKE+   + E ++ K    K +AK +ELE ++  L  EK  L         ++ 
Sbjct: 843  LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLA 902

Query: 650  DIKQERDQL----------LNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKM 699
            D ++  +QL          + EV     E   ++ E    KR   ++  E++   + L++
Sbjct: 903  DAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962

Query: 700  QLKSAQSELEQTRNTLKS----MEGSDGHAMKVAMGMQKQITAKRGQIDALQS---KIQF 752
             L   + E   T N +K+    M G D    K++   +      +  +D LQ+   K+  
Sbjct: 963  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNI 1022

Query: 753  LEEAMTNANKEKHFLK---EEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTNM 809
            L +A T   ++   L+   E++ KL  +L      K K+ G+L++ +     ++     +
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERA---KRKLEGDLKLAQESTMDMENDKQQL 1079

Query: 810  EVALDKASLQFAECQDIIQRQEQESVRLKLQHTLD-----IKELQGPGYTSNSSLKPRLL 864
            +  L+K   + +    I + +++++V ++LQ  +      I+EL        +S      
Sbjct: 1080 DEKLEKKEFEISNL--ISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEK 1137

Query: 865  QPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLKQLLQELRSVINEEPAVSLS 924
            Q + ++R    +      A   +    + N  +E   + L++ L+E  ++ +E    +L 
Sbjct: 1138 QRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEE-ATLQHEAMVAALR 1196

Query: 925  KTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTEG-SKSSETLSR------ 977
            K   D    LG   D ++    +            + L  + E  SK+   L +      
Sbjct: 1197 KKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLE 1256

Query: 978  EPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLTSSVEGSIGSTS 1037
            + V+      E+        +A    ++  A        +K  + S L+ S +    ST 
Sbjct: 1257 DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ---ASTQ 1313

Query: 1038 QYRSAK-PIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQ 1084
            Q    K  +      K++ +  ++++   C  L+ + E  Q    +LQ
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1361


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  129 bits (323), Expect = 2e-29
 Identities = 171/902 (18%), Positives = 395/902 (43%), Gaps = 115/902 (12%)

Query: 15   SSSGVTSNGGSSSSFFVSSIRGTIIENTSSAGTLTQVPFFPKYEVELDSPRKIIPSPGKE 74
            +S+ +  +  +SS   +SS+  ++    S  G LT+       ++   +  +      ++
Sbjct: 303  TSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQ 362

Query: 75   HFERVLEEY----------SHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQM 124
            H E++L E           +  V ++++ L  + + H++    L   +  L+T ++    
Sbjct: 363  HIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADR 422

Query: 125  ERDAMADIRRRESQSQEDLRNQLQN---TVHELEAAKCLKEDMLKDSNT-------QIEQ 174
            E+  + +    E +  EDL+ +++    T  +LE A   ++  + +          ++ +
Sbjct: 423  EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAE 482

Query: 175  LRKMMLSHE---------GVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKI 225
            LR+ + S++          +LQEI S+    E        E  S+   HF +      K 
Sbjct: 483  LRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE-HFGAREETHQKE 541

Query: 226  LRELDTEISYLKGRIFPVEDQLEALKSES-------QNKIELLLQQHQDRIEQLISEHEV 278
            ++ L T    L      ++ +LE    E+       ++K+E  +  HQ  +E+L      
Sbjct: 542  IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601

Query: 279  EITGLTEKASSARSQANSI----QSQMEIIQEQARNQNSMYMRQLSDL-----------E 323
             +   T + +  ++Q   +    Q ++E +Q Q  ++ + + +++  L           E
Sbjct: 602  GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661

Query: 324  STVSQLRSELREAKRMY----EDKTEELE------KQLVLANSELTEARTERDQFSQESG 373
            +++  +RS+L +A+  +    ED   +L+      K+L +  ++  E     D F+ +  
Sbjct: 662  NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK 721

Query: 374  NLDDQLQKLLA----------DLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDN 423
              +++L  L A          ++ K  ++L   ++Q K L       S     + REL  
Sbjct: 722  ATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 781

Query: 424  RNMEVQRLEALLKALKSECQGQMERQMAAIQGK-NESLEKVSSLTAQLESTKEMLRKVVE 482
            R +++  L+  L  + S+ +  +E+++  ++ K  E+ E+  S+   ++ T   L +  E
Sbjct: 782  RELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 840

Query: 483  ELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEG-- 540
            +       LE     ++D+    +EK+   E    ++ K + +++  + E+  +  +   
Sbjct: 841  QFNMLSSDLEKLRENLADMEAKFREKDEREE----QLIKAKEKLENDIAEIMKMSGDNSS 896

Query: 541  ------DHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAM-QVEKA 593
                  D LR  + + E L+L++T+ ++    L++ IE+MT    Q  + A    + EK 
Sbjct: 897  QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956

Query: 594  QLEKEIND--RRMELK--ELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVK 649
            +LE++++D  ++ME    + + LK + +    E + +  ++     K +    ++L   K
Sbjct: 957  ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL---K 1013

Query: 650  DIKQERDQLLNEVKTSRSELNNLS------EEYEVLKRNFRNKSEEMEMTTNKLKMQLKS 703
              ++E   LL E++  R + +         +  +++++  + K+E +    +  +   K 
Sbjct: 1014 GAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK- 1072

Query: 704  AQSELEQTR-NTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANK 762
             Q+EL+  + N LK++E  +          ++ +T +  +++  + +I+ L++A    ++
Sbjct: 1073 LQNELDTLKENNLKNVEELNKS--------KELLTVENQKMEEFRKEIETLKQAAAQKSQ 1124

Query: 763  EKHFLKEEKSKLSQELS---TVATEKNKMAGELEVLRSQERRLKEKVTNM--EVALDKAS 817
            +   L+EE  KL++EL       T   K+  E  VL +Q   +K++ +    +   +KAS
Sbjct: 1125 QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKAS 1184

Query: 818  LQ 819
            LQ
Sbjct: 1185 LQ 1186



 Score =  127 bits (320), Expect = 4e-29
 Identities = 147/742 (19%), Positives = 331/742 (44%), Gaps = 65/742 (8%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVID-LQTKLQEMQMERDAMAD 131
            K   E++  +Y H++++LQ + +     H K+   LR  ++  ++ K   ++  R  +  
Sbjct: 614  KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 673

Query: 132  IRRRESQSQEDLRNQLQNT---VHELEA--AKCLKEDMLKDSNTQ-----------IEQL 175
               +     ED  N+LQ     V ELE   AKC ++  + D+ T            ++ L
Sbjct: 674  AEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 733

Query: 176  RKMMLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISY 235
            RK     +  ++++R  L    EA+ K+I +H  +      S  S+I++ L+  + +++ 
Sbjct: 734  RKASSEGKSEMKKLRQQL----EAAEKQI-KHLEIEKNAESSKASSITRELQGRELKLTN 788

Query: 236  LKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQAN 295
            L+  +  V    E L+ E    +++L ++  +  E+ +S     +     K      Q N
Sbjct: 789  LQENLSEVSQVKETLEKE----LQILKEKFAEASEEAVSVQR-SMQETVNKLHQKEEQFN 843

Query: 296  SIQSQMEIIQEQARNQNSMYMRQLSDLESTVS---QLRSELREAKRMYEDKTEELEK--- 349
             + S +E ++E   +  + +  +    E  +    +L +++ E  +M  D + +L K   
Sbjct: 844  MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 903

Query: 350  QLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG 409
            +L L   ++ E + +  + ++ +  L   ++ +     + ++E + + E+ K+  +R   
Sbjct: 904  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK-- 961

Query: 410  NSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQ----GKNESLEKVSS 465
                +  L ++++  + + Q L+A  +   SE + + E  +  +Q       + L+    
Sbjct: 962  ----LSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE 1017

Query: 466  LTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSR 525
              + L    E LRK  ++  A + T E + + +  +T    E   ++E T     KL++ 
Sbjct: 1018 ENSGLLQELEELRKQADKAKAAQ-TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNE 1076

Query: 526  VDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTA 585
            +D  L+E        ++L+NV+ E    K  +T +++ +E  R++IE + Q   Q  +  
Sbjct: 1077 LDT-LKE--------NNLKNVE-ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQL 1126

Query: 586  GAMQVEKAQLEKEINDRRMELKELKILKDKKDA---KIRELEAR----VSDLELEKVKLV 638
             A+Q E  +L +E+   R E+   + L++++     ++ E++ R    + D + EK  L 
Sbjct: 1127 SALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ 1186

Query: 639  NAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLK 698
             + S     + +   E ++L NEV   R E N  ++    + +   +   ++E+    L+
Sbjct: 1187 KSISITSALLTEKDAELEKLRNEVTVLRGE-NASAKSLHSVVQTLESDKVKLELKVKNLE 1245

Query: 699  MQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMG-MQKQITAKRGQIDALQSKIQFLEEAM 757
            +QLK  + +L  +     +    D  A +  +  +   I   + +   L+ K++ + EA 
Sbjct: 1246 LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAA 1305

Query: 758  TNANKE--KHFLKEEKSKLSQE 777
             N N +   ++  +++ K S++
Sbjct: 1306 LNGNGDDLNNYDSDDQEKQSKK 1327



 Score =  115 bits (288), Expect = 2e-25
 Identities = 208/997 (20%), Positives = 393/997 (39%), Gaps = 193/997 (19%)

Query: 249  ALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQM------- 301
            A K      ++  L++ Q  IEQL++E ++E      + + A S    I+ ++       
Sbjct: 344  ARKISGTTALQEALKEKQQHIEQLLAERDLE----RAEVAKATSHVGEIEQELALARDGH 399

Query: 302  --EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED----------------- 342
               +++ +A+      M + +D E    +L ++L E KR  ED                 
Sbjct: 400  DQHVLELEAKMDQLRTMVEAADREKV--ELLNQLEEEKRKVEDLQFRVEEESITKGDLEV 457

Query: 343  -------KTEELEKQLVLANSELTEARTERDQ------------FSQESGNLDDQLQKLL 383
                   +  ELEK L L   E+ E R   +               QE  +L ++L+   
Sbjct: 458  ATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR 517

Query: 384  ADLHKRE----------KELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEA 433
             D H+RE          +E + +KE  K L+      S   + L+ +L++ N E   + A
Sbjct: 518  TD-HQREITSLKEHFGAREETHQKEI-KALYTATEKLSKENESLKSKLEHANKENSDVIA 575

Query: 434  LLK-----ALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEEL---- 484
            L K     A+ S  Q   E +++  +G      + + L  Q+E  +   +  +E L    
Sbjct: 576  LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 635

Query: 485  -TAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHL 543
             + +    +  E   + L   ++EKE ++EA  +++ K     D  L E++   N+    
Sbjct: 636  DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE---DQHLVEMEDTLNKLQEA 692

Query: 544  RNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRR 603
                 E E L+ +  E+ KVI+    Q++   + +           ++   L K  ++ +
Sbjct: 693  EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL-----------LDLDALRKASSEGK 741

Query: 604  MELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVK 663
             E+K+L+        ++   E ++  LE+EK    NA S +  ++    Q R+  L  ++
Sbjct: 742  SEMKKLR-------QQLEAAEKQIKHLEIEK----NAESSKASSITRELQGRELKLTNLQ 790

Query: 664  TSRSELNNLSE----EYEVLKRNFRNKSEE-------MEMTTNKLKM---QLKSAQSELE 709
             + SE++ + E    E ++LK  F   SEE       M+ T NKL     Q     S+LE
Sbjct: 791  ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 850

Query: 710  QTRNTLKSMEGSD---------------------GHAMKVAMGMQKQITAKRGQIDALQS 748
            + R  L  ME                           MK++     Q+T    ++   + 
Sbjct: 851  KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER 910

Query: 749  KIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVTN 808
             ++ L+  +T AN+   FL+    K  ++++  A +  + A +      +++ L+ K+++
Sbjct: 911  DVEELQLKLTKANENASFLQ----KSIEDMTVKAEQSQQEAAKKH--EEEKKELERKLSD 964

Query: 809  MEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSLKPR------ 862
            +E  ++ +  Q   CQ++  R E+ +   K +H   ++ LQ     +   LK        
Sbjct: 965  LEKKMETSHNQ---CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSG 1021

Query: 863  LLQPASVTRSHSNVPSSQSTASF---LSHHSTKANTLKEDPTRDLKQLLQELRSVINEEP 919
            LLQ     R  ++   +  TA     +    TK  T       D KQ   +L++ ++   
Sbjct: 1022 LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1081

Query: 920  AVSLSKTEEDGRTS--LGALEDRVRDCITE-SSLRSDMCHRSNNSLRDSTEGSKSSETL- 975
              +L   EE  ++   L     ++ +   E  +L+     +S        E  K +E L 
Sbjct: 1082 ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELG 1141

Query: 976  -SREPVTLHAGDREDPS----GCFTFTSAASPSVKNSASRSFNSSPKKSPVHSLLT---S 1027
             SR+ VT H    E+ S             S  +K++     +     S   +LLT   +
Sbjct: 1142 RSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA 1201

Query: 1028 SVEGSIGSTSQYR----SAKPIHS------SDSVK-------------DSQSPPIETTGK 1064
             +E      +  R    SAK +HS      SD VK             +++     ++G 
Sbjct: 1202 ELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 1261

Query: 1065 TC-------RKLQNRLESLQTLVEDLQLKNQAMSSMI 1094
            T        R  +++++ L +++ DLQ KNQ +   +
Sbjct: 1262 TDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV 1298



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 167/873 (19%), Positives = 358/873 (41%), Gaps = 107/873 (12%)

Query: 288  SSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEEL 347
            SS  S  +S  S+  ++ E +    S Y R++S   +    L+ + +  +++  ++  E 
Sbjct: 320  SSVASSVSSRPSRTGLLTETS----SRYARKISGTTALQEALKEKQQHIEQLLAERDLE- 374

Query: 348  EKQLVLANS-------ELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQN 400
              ++  A S       EL  AR   DQ   E     DQL+ ++    + + EL  + E+ 
Sbjct: 375  RAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEE 434

Query: 401  KRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNESL 460
            KR           ++ L+  ++  ++    LE    + KS    ++E+ +A        +
Sbjct: 435  KR----------KVEDLQFRVEEESITKGDLEVATVSEKSRIM-ELEKDLAL------RV 477

Query: 461  EKVSSLTAQLESTK-----EMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEAT 515
            ++V+ L  +LES K     +M   +++E+++ +  LE +        TSL+E   A E T
Sbjct: 478  QEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREET 537

Query: 516  NA-EITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENM 574
            +  EI  L +  +   +E + LK++ +H     ++  AL      K K+   +    + M
Sbjct: 538  HQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALW-----KSKLETAIASHQQAM 592

Query: 575  TQLVGQHGRTAGAMQVEKAQLEKEINDRRMELK-ELKILKDKKDAKIRELEARVSDLELE 633
             +L     +  G    E A+L+ +I   R++ + E++ L++++D+   E  A   ++E  
Sbjct: 593  EELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS---ERAAHAKEMEAL 649

Query: 634  KVKLVNAGSERLRAVKDIKQE----RDQLLNEVKTSRSELNNLS---EEYEVLKRNFRNK 686
            + KL+    E+  +++ I+ +     DQ L E++ + ++L       +E EVL+     +
Sbjct: 650  RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 709

Query: 687  SEEMEMTTNKLKM--------------------QLKSAQSELEQTRNTLKSMEGSDGHAM 726
            ++ ++  T++LK                     ++K  + +LE     +K +E       
Sbjct: 710  TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 769

Query: 727  KVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKN 786
              A  + +++  +  ++  LQ  +  + +      KE   LKE+ ++ S+E  +V     
Sbjct: 770  SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 829

Query: 787  KMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDIK 846
            +   +L     Q   L   +  +   L     +F E  +    +E++ ++ K +   DI 
Sbjct: 830  ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDE----REEQLIKAKEKLENDIA 885

Query: 847  ELQGPGYTSNSSLKPR----LLQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTR 902
            E+      ++S L        L+   V      +  +   ASFL   S +  T+K + ++
Sbjct: 886  EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL-QKSIEDMTVKAEQSQ 944

Query: 903  DLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLR-SDMCHRSNNS 961
                   E      E     L K  E        L+ R     +E+  +  ++      +
Sbjct: 945  QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 1004

Query: 962  LRDSTEGSKSSETLSREPVTLHAGDREDPSGCF-TFTSAASPSVKNSASRSFNSSPKKSP 1020
            L D+ +  K              G RE+ SG           + K  A+++   + +   
Sbjct: 1005 LLDTEDKLK--------------GAREENSGLLQELEELRKQADKAKAAQTAEDAMQIME 1050

Query: 1021 VHSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKT-------CRKLQNRL 1073
              +   +    S+  T Q  +AK  +  D++K++    +E   K+        +K++   
Sbjct: 1051 QMTKEKTETLASLEDTKQ-TNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109

Query: 1074 ESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKD 1106
            + ++TL +    K+Q +S++   QE+ ++  ++
Sbjct: 1110 KEIETLKQAAAQKSQQLSAL---QEENVKLAEE 1139


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score =  127 bits (320), Expect = 4e-29
 Identities = 209/978 (21%), Positives = 405/978 (41%), Gaps = 175/978 (17%)

Query: 82   EYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQE 141
            E + +V++LQR+L+E  E+ ++QK  L  S + L+ +L+E   E   + ++  R     +
Sbjct: 363  ELTRKVEELQRKLDE--EVKKRQK--LEPSQVGLERQLEEKTEECSRLQELLERRKGEAQ 418

Query: 142  DLRNQLQNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASG 201
                +LQN    L+      ED+     TQ+ +L+  +   +G       +L D  E   
Sbjct: 419  QSNKELQNMKRLLDQG----EDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLET-- 472

Query: 202  KKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELL 261
            +++ E               + + LR  + E++ LKG +       E + S  Q ++E +
Sbjct: 473  RELLEEVLEGK-------QRVEEQLRLRERELTALKGAL------KEEVASRDQ-EVEHV 518

Query: 262  LQQHQDRIEQL---ISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQ 318
             QQ+Q   EQL   + +   +   L  +     +    +Q ++E   E+  +  SM+ + 
Sbjct: 519  RQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKN 578

Query: 319  LSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQESGNLDDQ 378
              DL +T    + EL + +   E+  EEL +++ +   EL +AR       Q      + 
Sbjct: 579  KEDLRAT----KQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQV-----EV 629

Query: 379  LQKLLADLHKREKELSLEKEQNK---RLWDRDTGNSITIDHLR----RELDNRNMEVQRL 431
            L+K L    +  KEL  E++  +   R  DR+    + +  +     REL+ +N+++Q+ 
Sbjct: 630  LKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQK- 688

Query: 432  EALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTL 491
               L+ L+ +C+   + +M                 A+ E+T    R+   E T ++   
Sbjct: 689  --TLQQLRQDCEEASKAKM----------------VAEAEATVLGQRRAAVETTLRETQE 730

Query: 492  ESSE--RTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTE 549
            E+ E  R I  L   L+E    ++   A   +LR     KLQ L+  K + +   N   E
Sbjct: 731  ENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRD----KLQRLEAEKQQLEEALNASQE 786

Query: 550  CE--------ALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLE--KEI 599
             E        AL+ ++ E  + +  L Q+ + + + + + G+    ++  KA+LE  K +
Sbjct: 787  EEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRL 846

Query: 600  NDRRMEL--KEL-KILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERD 656
             DR ++   KEL KI +D K A +++L+A++ D + EK +         R V D +++  
Sbjct: 847  LDRTVDRLNKELEKIGEDSKQA-LQQLQAQLEDYK-EKAR---------REVADAQRQAK 895

Query: 657  QLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLK 716
               +E + +   L+ L +E +                  +L+  L+++Q+E +  R    
Sbjct: 896  DWASEAEKTSGGLSRLQDEIQ------------------RLRQALQASQAERDTAR---- 933

Query: 717  SMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQ 776
                           + K++ A+R         +Q LE+   N  + +     +   L +
Sbjct: 934  ---------------LDKELLAQR---------LQGLEQEAENKKRSQDDRARQLKGLEE 969

Query: 777  ELSTVATEKNKMAGELEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVR 836
            ++S + TE ++    +E+L  +  R +++V  +   L          Q+   RQ+ E  +
Sbjct: 970  KVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL---------MQERSARQDLECDK 1020

Query: 837  LKLQHTLDIKELQGPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHH---STKA 893
            + L+               N  LK RL       +  +++   +S    L        + 
Sbjct: 1021 ISLER-------------QNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE 1067

Query: 894  NTLKEDPTRDLKQLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSD 953
             T+ +   R L++ ++EL S+  E+    ++  ++     + AL+ +V D   E   R D
Sbjct: 1068 KTVLQSTNRKLERKVKEL-SIQIEDERQHVNDQKDQLSLRVKALKRQV-DEAEEEIERLD 1125

Query: 954  MCHRSNNSLRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKN---SASR 1010
                    LR   +     +    E +       E  S      SAA  ++KN   S+  
Sbjct: 1126 -------GLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDE 1178

Query: 1011 SFNSSPKKSPVHSLLTSS 1028
             F+S    S + SLLT S
Sbjct: 1179 EFDSVYDPSSIASLLTES 1196



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 141/659 (21%), Positives = 273/659 (41%), Gaps = 109/659 (16%)

Query: 56   KYEVELDSPRKIIPSPGKEH--FERVLEEYSHQVKDLQRRLNESNE-------LHEKQKF 106
            +Y+ + +  R+ +    ++H   E   ++ S  V+ LQR L E++E       + +K K 
Sbjct: 521  QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE 580

Query: 107  YLR---QSVIDLQTKLQEMQMERDAMADIRRRE----------SQSQEDLRNQL---QNT 150
             LR   Q ++ L+ + +EM+ E     ++ +RE          ++  E L+ +L   Q  
Sbjct: 581  DLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640

Query: 151  VHELEAAKCLKEDMLKDSNTQIE--------------QLRKMMLSHEGVLQEIRSILVDF 196
            + EL+A +  +E   +  + ++E              +L +  L  +  LQ++R    D 
Sbjct: 641  LKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ---DC 697

Query: 197  EEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQL--------- 247
            EEAS  K+      + L  R   +A+   LRE   E    + RI  +E QL         
Sbjct: 698  EEASKAKMVAEAEATVLGQRR--AAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG 755

Query: 248  -EALKSESQNKIELLLQQHQDRIEQLISEHEVE---------ITGLTEKASSARSQANSI 297
             EA+++  ++K++ L  + Q   E L +  E E         +    E+A    ++    
Sbjct: 756  GEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQE 815

Query: 298  QSQMEIIQEQARNQNSMYMRQLSDLES-------TVSQLRSELR----EAKRMYEDKTEE 346
            Q  +    E+   Q  +  R  ++LE        TV +L  EL     ++K+  +    +
Sbjct: 816  QQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQ 875

Query: 347  LEKQLVLANSELTEARTERDQFSQES-------GNLDDQLQKLLADLHKREKELSLEKEQ 399
            LE     A  E+ +A+ +   ++ E+         L D++Q+L   L   + E    +  
Sbjct: 876  LEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLD 935

Query: 400  NKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQGKNES 459
             + L  R  G     ++ +R  D+R  +++ LE  +  L++E   +           N  
Sbjct: 936  KELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRG 995

Query: 460  LEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTISDLTTSLQEKERAIEATNAEI 519
             ++V  L  +L       R   ++L   K++L   ER   DL T L   E   +  +A +
Sbjct: 996  RDQVDQLRTELMQE----RSARQDLECDKISL---ERQNKDLKTRLASSE-GFQKPSASL 1047

Query: 520  TKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVG 579
            ++L S+  L  + LQ  + E   L++   + E          + ++ L  QIE+  Q V 
Sbjct: 1048 SQLESQNQLLQERLQAEEREKTVLQSTNRKLE----------RKVKELSIQIEDERQHVN 1097

Query: 580  QHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRE-------LEARVSDLE 631
                    + +    L++++++   E++ L  L+ K   ++ E       L+AR+  LE
Sbjct: 1098 DQ---KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLE 1153



 Score = 77.4 bits (189), Expect = 7e-14
 Identities = 131/610 (21%), Positives = 243/610 (39%), Gaps = 86/610 (14%)

Query: 434 LLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAK------ 487
           +L+   SE +  + R+++ +  K + L  VSS + +  + +  L + VEEL  K      
Sbjct: 321 ILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVK 380

Query: 488 ------------KMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLKLQELQH 535
                       +  LE      S L   L+ ++   + +N E+  ++  +D + ++L+H
Sbjct: 381 KRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLD-QGEDLRH 439

Query: 536 --------LKNEGDHLRNVQTECEALKLQMTE-----------KDKVIEILRQQIENMTQ 576
                   L+N+  H++  +   E L   + E           K +V E LR +   +T 
Sbjct: 440 GLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTA 499

Query: 577 LVG-------------QHGRTAGAMQVEKAQLEKEINDRRMELKELKILKDKKDAKIREL 623
           L G             +H R     Q +  QL + + D   +   L+  + K  A +R L
Sbjct: 500 LKGALKEEVASRDQEVEHVRQ--QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGL 557

Query: 624 EARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNF 683
           +  + +   E     +   +    ++  KQE  QL  E +    E   L E+ EVL+R  
Sbjct: 558 QRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEE---LGEKIEVLQREL 614

Query: 684 RNKSEEMEMT--TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRG 741
                    T     LK +L   Q EL++ +   +S E +  H  +    ++KQ+   R 
Sbjct: 615 EQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDR---ELEKQLAVLRV 671

Query: 742 QID----------ALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGE 791
           + D           LQ  +Q L +    A+K K   + E + L Q  + V T   +   E
Sbjct: 672 EADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEE 731

Query: 792 LEVLRSQERRLKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTLDI-KELQG 850
            +  R +   L++++      +D      A  +D +QR E E  + +L+  L+  +E +G
Sbjct: 732 NDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAE--KQQLEEALNASQEEEG 789

Query: 851 PGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTAS-FLSHHSTKANTLKEDPT--RDLKQL 907
               +  +L+ RL       R  + +   Q T +  L     +   L+       + K+L
Sbjct: 790 SLAAAKRALEARL---EEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRL 846

Query: 908 LQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSLRDSTE 967
           L      +N+E    L K  ED + +L  L+ ++ D   +   R ++      +   ++E
Sbjct: 847 LDRTVDRLNKE----LEKIGEDSKQALQQLQAQLED--YKEKARREVADAQRQAKDWASE 900

Query: 968 GSKSSETLSR 977
             K+S  LSR
Sbjct: 901 AEKTSGGLSR 910


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  127 bits (319), Expect = 6e-29
 Identities = 232/1177 (19%), Positives = 473/1177 (40%), Gaps = 183/1177 (15%)

Query: 73   KEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADI 132
            ++  +   +E    V  LQ  +  +++ ++K    L++ ++ L+   QE   E     + 
Sbjct: 202  QKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEA 261

Query: 133  RRRESQSQEDLRNQL-QNTVHELEAAKCLKEDMLKDSNTQIEQLRKMMLSHEGVLQEIRS 191
              +E +++ +  N+L +N V + EA++   +++ K    ++E LRK   S+     +I S
Sbjct: 262  SAKEHEAEINKLNELKENLVKQCEASE---KNIQKKYECELENLRKAT-SNANQDNQICS 317

Query: 192  ILVD----FEEASGKKICE-HDSMSTLH-----FRSLGSAISKILRELDTEISYLKGRIF 241
            IL+      E+   +K+    D++  L       +   + ++ +  +L+ +  ++K   F
Sbjct: 318  ILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFF 377

Query: 242  PVEDQLE-------ALKSESQNKIELL--------------LQQHQDRIEQLISEHEVEI 280
               + LE         K E    IE L              ++QH   ++ L  +H+ EI
Sbjct: 378  HEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEI 437

Query: 281  TGLTEK-ASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLEST---VSQLRSELREA 336
            + L E   S +  +  ++  +++ ++EQ  N        + + ES    +  L++EL E+
Sbjct: 438  SELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGES 497

Query: 337  KRMYEDKTEELEKQLVLANSELTE----ARTERDQFSQESGNLDDQLQKLLADLHK-REK 391
                  + E +++Q      EL +    A TE+D   +    L  + +KLL+      E 
Sbjct: 498  AGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPEL 557

Query: 392  ELSLEKEQNKR------LWDRDTG--------NSIT---------IDHLRRELDNRNMEV 428
            E +++  Q K       L  RDT         NS+T         + +   E+DN + + 
Sbjct: 558  ENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKC 617

Query: 429  QRLEALLKALK-----------------SECQGQMERQMAAIQGKNESLEKVSSLTAQLE 471
            +R E L+  L                  +E  G +E  +      ++ LEK+      L 
Sbjct: 618  EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS 677

Query: 472  STKEMLRKVVEELTAKKMTLESSERTIS-DLTTSLQEKERAIEATNAEITKLRSRVDLKL 530
              KE+L   V+ L  +   L S ++ +S DL   L +KE  I      IT+L  ++ L +
Sbjct: 678  EDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI--LKEHITQLEKKLQLMV 735

Query: 531  QELQHLKNEGDHLRNVQTECEALKLQMTE--KDKVIEILRQQIE----NMTQLVGQHGRT 584
            +E  +L      L N Q +   +K Q+    K+   E+     E    N+ Q VG+   +
Sbjct: 736  EEQDNLNKL---LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE---S 789

Query: 585  AGAMQVEKAQLEKEINDRRMEL-KELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSE 643
               +  EK  L  + +++ +EL KE+K L+++   +  EL++ + D E EKV L      
Sbjct: 790  LAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL------ 843

Query: 644  RLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKS 703
              + +++I+ E++ L +++     E+ N +E+  +  +N   + EE+  T +K ++  + 
Sbjct: 844  -RKELEEIQSEKEALQSDLL----EMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK 898

Query: 704  AQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR--------GQIDALQSKIQFLEE 755
             +  +++  N    +E  +    +  + + K   AK           +  L+ KI+ LE+
Sbjct: 899  EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEK 958

Query: 756  --------------AMTNANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERR 801
                              A KE    ++E   + +EL ++ +EK++++  +  L      
Sbjct: 959  ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 1018

Query: 802  LKEKVTNMEVALDKASLQFAECQDIIQRQEQESVRLKLQHTL-------DIKELQGPGYT 854
             K  +   E   ++  ++     +   R E  + +L+   TL       D ++L     T
Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLR-NSTLQCETINSDNEDLLARIET 1077

Query: 855  SNSSLKPRLLQPASVTRSHSNVPSSQSTASF-----LSHHSTKANTLKE------DPTRD 903
              S+ K   +Q   V R+ + V              +  H+T  N L+E         + 
Sbjct: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137

Query: 904  LKQLLQELRSVINEEPAVSLSKTE-EDGRTSLGALEDRVRDCITESSLRSDMCHRSNNSL 962
            L++ +QEL  V  +    +L   E  D    +  L  ++ +               NN +
Sbjct: 1138 LQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTN--------------KNNKI 1183

Query: 963  RDSTEGSK----SSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKK 1018
             D  +  K      ETL  E  +L +  ++     +   +     +     +    S + 
Sbjct: 1184 EDLEQEIKIQKQKQETLQEEITSLQSSVQQ-----YEEKNTKIKQLLVKTKKELADSKQA 1238

Query: 1019 SPVHSLLTSSVEGSIGSTSQYRSAKPIHSSD------SVKDSQSPPIETTGKTCRKLQNR 1072
               H +L +S++G + ++ Q      I  ++       + +      E   +T    Q R
Sbjct: 1239 ETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298

Query: 1073 LESLQTLVEDLQLKNQAMSSMIRNQEKRIQKVKDQEK 1109
            + +LQ      + +   ++S   + + R+  V  Q+K
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335



 Score =  110 bits (276), Expect = 6e-24
 Identities = 220/1110 (19%), Positives = 444/1110 (40%), Gaps = 220/1110 (19%)

Query: 102  EKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKC-- 159
            +K+   ++Q V D  TK          M D  +   QS  +   +++N  +EL A +   
Sbjct: 96   KKENIKMKQEVEDSVTK----------MGDAHKELEQSHINYVKEIENLKNELMAVRSKY 145

Query: 160  ------LKEDMLKDSNTQIE---QLRKMMLSHEGVL---QEIRSILVDFEEASGKKICEH 207
                  L++ + +  NTQ+E   QL+    S + V    +EI  I   FEE    +I   
Sbjct: 146  SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEE----QILYL 201

Query: 208  DSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQD 267
                          ++++   ++    + +  I  ++++L  LK+  Q +++ L+ Q   
Sbjct: 202  QKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQ--- 258

Query: 268  RIEQLISEHEVEITGLTEKASSARSQANS----IQSQMEIIQEQAR------NQNSMYMR 317
             IE    EHE EI  L E   +   Q  +    IQ + E   E  R      NQ++    
Sbjct: 259  -IEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICS 317

Query: 318  QLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELT-----------EARTERD 366
             L    + V Q+   + E  +  ED  +ELE Q  +   E+T           +A+  +D
Sbjct: 318  ILLQENTFVEQV---VNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKD 374

Query: 367  QFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDNRNM 426
            +F  E  +L+ ++ +LL  L K E+   +EK +++ L   +     T++   RE+ +   
Sbjct: 375  EFFHEREDLEFKINELL--LAKEEQGCVIEKLKSE-LAGLNKQFCYTVEQHNREVQSLKE 431

Query: 427  EVQR-LEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEEL- 484
            + Q+ +  L +   S+ + +    M  IQG  E  E +     +     E LR+++E L 
Sbjct: 432  QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 491

Query: 485  -----TAKKMTLE---SSERTISD-------LTTSLQEKERAIEATN---AEITKLRSRV 526
                 +A K++ E     ++  SD       L T+  EK+  +E  N    E  KL S+ 
Sbjct: 492  TELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQ 551

Query: 527  DLKLQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMTQLVGQHGRTAG 586
            +L + EL++       ++N+Q +     L ++++D +++ L  +I ++T+          
Sbjct: 552  EL-VPELENT------IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTE---------- 594

Query: 587  AMQVEKAQLEKEINDRRMELKELKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLR 646
                EK     ++ +   E+       ++++  I EL  +V        +L    +E   
Sbjct: 595  ----EKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTG 650

Query: 647  AVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQS 706
             +++  +E+DQ   +++    ++  LSE+ EVL    ++  EE     NKL  + K    
Sbjct: 651  GLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE----NNKLSSEKKQLSR 706

Query: 707  ELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANK---- 762
            +LE   +                   QK+    +  I  L+ K+Q + E   N NK    
Sbjct: 707  DLEVFLS-------------------QKEDVILKEHITQLEKKLQLMVEEQDNLNKLLEN 747

Query: 763  ---EKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQERRLK--------------EK 805
               +K F+K +     +E+ +  +E ++    + VL++    L               EK
Sbjct: 748  EQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEK 807

Query: 806  VTNMEVAL----DKASLQFAECQDIIQRQEQESVRLKLQHTLDIKELQGPGYTSNSSL-- 859
            V  +E  +    +++ +Q  E + +++  EQE V L+ +    ++E+Q       S L  
Sbjct: 808  VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKE----LEEIQSEKEALQSDLLE 863

Query: 860  ------KPRL--------LQPASVTRSHSNVPSSQSTASFLSHHSTKANTLKEDPTRDLK 905
                  K RL        ++  S T S S + + +    F+  H      L++   RD +
Sbjct: 864  MKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC-FIKEHENLKPLLEQKELRDRR 922

Query: 906  QLLQELRSVINEEPAVSLSKTEEDGRTSLGALEDRVRDCITESSLRSDMCHRSN----NS 961
              L  L+  + + P+V     + D  +S+  LE+++ +   E   + +  ++       +
Sbjct: 923  AELILLKDSLAKSPSV-----KNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA 977

Query: 962  LRDSTEGSKSSETLSREPVTLHAGDREDPSGCFTFTSAASPSVKNSASRSFNSSPKKSPV 1021
             ++     K ++T+  E  +L +   +                                 
Sbjct: 978  KKELDSSRKETQTVKEELESLRSEKDQ--------------------------------- 1004

Query: 1022 HSLLTSSVEGSIGSTSQYRSAKPIHSSDSVKDSQSPPIETTGKTCRKLQNRLESLQTLVE 1081
               L++S+   I     Y++    +      + QS  ++   +     ++R+E L   + 
Sbjct: 1005 ---LSASMRDLIQGAESYKNLLLEY------EKQSEQLDVEKERANNFEHRIEDLTRQLR 1055

Query: 1082 DLQLKNQAMSSMIRNQEKRIQKVKDQEKML 1111
            +  L+ + ++S   +   RI+ ++   K+L
Sbjct: 1056 NSTLQCETINSDNEDLLARIETLQSNAKLL 1085



 Score =  110 bits (276), Expect = 6e-24
 Identities = 186/937 (19%), Positives = 389/937 (41%), Gaps = 179/937 (19%)

Query: 74   EHFERVLEEYSHQVK-------DLQRRLNE-SNELHE--KQKFYLRQSVIDLQTKLQEMQ 123
            E  ER++ E   +V+       +L++++NE +  L E  K+K    Q +  L  +++ + 
Sbjct: 618  EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS 677

Query: 124  MERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDM-LKDSNTQIEQLRKMMLSH 182
             +++ ++   +   +    L ++ +    +LE     KED+ LK+  TQ+E+  ++M+  
Sbjct: 678  EDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE 737

Query: 183  EGVLQE-----------IRSILVDFEEASGKKICEHDSMSTLH--FRSLGSAISKILREL 229
            +  L +           +++ L  F +  G ++ E      +    +++G +++KI  E 
Sbjct: 738  QDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEK 797

Query: 230  DTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASS 289
                     ++  +E +++ L+ ES  + E         ++ L+ ++E E   L ++   
Sbjct: 798  CNLAFQRDEKVLELEKEIKCLQEESVVQCE--------ELKSLLRDYEQEKVLLRKELEE 849

Query: 290  ARSQANSIQS---QMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEE 346
             +S+  ++QS   +M+   E+ R +N   + Q+ ++  T S  +SE+   K     K  E
Sbjct: 850  IQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCS--KSEIHNEKEKCFIKEHE 907

Query: 347  LEKQLVLANSELTEARTE----RDQFSQESGNLDDQL---QKLLADLHKREKELSLEKEQ 399
              K L L   EL + R E    +D  ++     +D L   ++L   +   EKE   ++E+
Sbjct: 908  NLKPL-LEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEK 966

Query: 400  NKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSECQGQMERQMAAIQG---- 455
              ++        +     ++ELD+   E Q ++  L++L+SE           IQG    
Sbjct: 967  INKI-------KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESY 1019

Query: 456  KNESLE--------------------KVSSLTAQLESTK---EMLRKVVEELTAKKMTLE 492
            KN  LE                    ++  LT QL ++    E +    E+L A+  TL+
Sbjct: 1020 KNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQ 1079

Query: 493  SSERTIS---------------DLTTSLQEKERAI----------EATNAEITKLRSRVD 527
            S+ + +                +L     +KE+ I          E    ++ K + ++ 
Sbjct: 1080 SNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQ 1139

Query: 528  LKLQELQHLKNEGDHLRNVQTEC-------EALKLQMTEKDKVIEILRQQIENMTQLVGQ 580
              +QEL+ +K +      +  E        + L  ++T K+  IE L Q+I+   Q    
Sbjct: 1140 KTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQET 1199

Query: 581  HGRTAGAMQVEKAQLE-KEINDRRMELKELKILKDKKDAKIR----------ELEARVSD 629
                  ++Q    Q E K    +++ +K  K L D K A+            ELEA    
Sbjct: 1200 LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQ 1259

Query: 630  LELEKVKLVNAGSERLRAVKDIKQERDQ--------------LLNEVKTSRSELNNLSEE 675
            +E+ K++L    SE+ +  + +K   +Q              L  E + +++E   ++ E
Sbjct: 1260 VEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSE 1319

Query: 676  YEVLK-------RNFRNKS-------------EEMEMTTNKLKMQLKSAQSELEQTRNTL 715
            +E  K       +  +NKS             E +EM  ++LK++L+ +Q+ L+   + L
Sbjct: 1320 FESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSEL 1379

Query: 716  KSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSK-L 774
            ++++      ++    M ++  +K  +          L E + +   E   +K E ++ +
Sbjct: 1380 QTLQSEHDTLLERHNKMLQETVSKEAE----------LREKLCSIQSENMMMKSEHTQTV 1429

Query: 775  SQELSTVATEKNKMAGELEVLRSQERR----LKEKVTNMEVALDKASLQFAECQDIIQRQ 830
            SQ  S     +N    ++  L+ + R+    L+++++ ME  L +   +      +  +Q
Sbjct: 1430 SQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQ 1489

Query: 831  EQESVR--------LKLQHTLDIKELQGPGYTSNSSL 859
              +++R        L   HT+  +E +G   T   S+
Sbjct: 1490 SLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESV 1526



 Score = 35.4 bits (80), Expect = 0.30
 Identities = 60/261 (22%), Positives = 109/261 (41%), Gaps = 41/261 (15%)

Query: 664 TSRSELNNLSEEYEVLKRNFRNKSEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDG 723
           T +S+L  L +E +++K      +++  M   K K +    + E+E+ R+          
Sbjct: 17  TGKSKLETLPKE-DLIKF-----AKKQMMLIQKAKSRCTELEKEIEELRSK--------- 61

Query: 724 HAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKSKLSQELSTVAT 783
               V  G    I A   ++DAL      LE+A T   ++   LK+E  K+ QE+    T
Sbjct: 62  ---PVTEGTGDIIKALTERLDAL-----LLEKAETE--QQCLSLKKENIKMKQEVEDSVT 111

Query: 784 EKNKMAGELEVLRSQERRLKEKVTNMEVAL------DKASLQFAECQDIIQRQEQESVRL 837
           +      ELE       +  E + N  +A+      DKA+LQ  + ++ +  Q + S +L
Sbjct: 112 KMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQ-KQLEEAMNTQLELSEQL 170

Query: 838 KLQHTLD--IKELQ------GPGYTSNSSLKPRLLQPASVTRSHSNVPSSQSTASFLSHH 889
           K Q+  +  +K+LQ       PG+        + L   +  +  +         +   H+
Sbjct: 171 KFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHY 230

Query: 890 STKANTLKEDPTRDLKQLLQE 910
               N+L+E+    LK + QE
Sbjct: 231 QKNINSLQEE-LLQLKAIHQE 250


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.123    0.315 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,933,769
Number of Sequences: 37866
Number of extensions: 1523800
Number of successful extensions: 23883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 439
Number of HSP's successfully gapped in prelim test: 1240
Number of HSP's that attempted gapping in prelim test: 8468
Number of HSP's gapped (non-prelim): 7205
length of query: 1113
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1000
effective length of database: 13,968,660
effective search space: 13968660000
effective search space used: 13968660000
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.