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Search of human proteins with 112363100
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform
a [Homo sapiens]
(1071 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 2125 0.0
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 1662 0.0
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 1417 0.0
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 1246 0.0
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 1229 0.0
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 737 0.0
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 109 1e-23
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 106 1e-22
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 106 1e-22
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 105 2e-22
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 105 2e-22
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 105 2e-22
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 105 2e-22
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 100 1e-20
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 100 1e-20
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 96 1e-19
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 96 1e-19
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 96 2e-19
gi|4505507 oligophrenin 1 [Homo sapiens] 94 7e-19
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap... 92 2e-18
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi... 92 2e-18
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 92 3e-18
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 92 3e-18
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 92 3e-18
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 92 3e-18
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 89 2e-17
gi|188497642 ARHGAP15 [Homo sapiens] 89 3e-17
gi|89886350 Rho GTPase activating protein 11B [Homo sapiens] 88 4e-17
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 88 4e-17
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 87 8e-17
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 2125 bits (5507), Expect = 0.0
Identities = 1071/1071 (100%), Positives = 1071/1071 (100%)
Query: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
Query: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK
Sbjct: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
Query: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240
LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT
Sbjct: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240
Query: 241 ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300
ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL
Sbjct: 241 ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300
Query: 301 NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360
NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ
Sbjct: 301 NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360
Query: 361 PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420
PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME
Sbjct: 361 PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420
Query: 421 SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480
SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE
Sbjct: 421 SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480
Query: 481 SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540
SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN
Sbjct: 481 SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540
Query: 541 AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600
AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH
Sbjct: 541 AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600
Query: 601 IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660
IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC
Sbjct: 601 IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660
Query: 661 QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720
QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE
Sbjct: 661 QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720
Query: 721 HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780
HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ
Sbjct: 721 HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780
Query: 781 YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR 840
YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR
Sbjct: 781 YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR 840
Query: 841 PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS 900
PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS
Sbjct: 841 PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS 900
Query: 901 LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL 960
LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL
Sbjct: 901 LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL 960
Query: 961 ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC 1020
ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC
Sbjct: 961 ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC 1020
Query: 1021 AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV 1071
AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV
Sbjct: 1021 AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV 1071
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 1662 bits (4305), Expect = 0.0
Identities = 836/836 (100%), Positives = 836/836 (100%)
Query: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
Query: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK
Sbjct: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
Query: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240
LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT
Sbjct: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240
Query: 241 ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300
ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL
Sbjct: 241 ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300
Query: 301 NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360
NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ
Sbjct: 301 NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360
Query: 361 PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420
PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME
Sbjct: 361 PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420
Query: 421 SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480
SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE
Sbjct: 421 SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480
Query: 481 SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540
SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN
Sbjct: 481 SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540
Query: 541 AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600
AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH
Sbjct: 541 AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600
Query: 601 IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660
IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC
Sbjct: 601 IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660
Query: 661 QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720
QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE
Sbjct: 661 QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720
Query: 721 HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780
HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ
Sbjct: 721 HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780
Query: 781 YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINK 836
YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINK
Sbjct: 781 YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINK 836
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
Length = 1085
Score = 1417 bits (3667), Expect = 0.0
Identities = 736/1108 (66%), Positives = 872/1108 (78%), Gaps = 60/1108 (5%)
Query: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
M++P++FKKDKEIIAEY++QVKEIRAQL EQ KCL+QQ E+RVQLLQDLQDFFRKKAEIE
Sbjct: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
Query: 61 MDYSRNLEKLAERFLAKTRSTKD-QQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDI 119
+YSRNLEKLAERF+AKTRSTKD QQ+KKDQN+LSPVNCW LLLNQV+RES+DH TLSDI
Sbjct: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
Query: 120 YLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQS 179
YLNN+I RF+Q+SEDS R+FKKSKE+ QL +DLMKVLNELY+VMKTYHMY+A+SISA+S
Sbjct: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
Query: 180 KLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKY 239
KLKEAEKQEEKQIG RS D ++R+EE+H RRSSVKKIEKMKEKRQAKY
Sbjct: 181 KLKEAEKQEEKQIG-----------RSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKY 229
Query: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
+ENKLK+IKARNEYLL LEATNASVFKYYIHDLSDLID CCDLGYHASLNRALRT+LSAE
Sbjct: 230 SENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLID-CCDLGYHASLNRALRTYLSAE 288
Query: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
NLE S+HEGLD IENAV+NL+ SDKQR MEMY FCPPMKFEFQ HMGD Q+ AQ
Sbjct: 289 YNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQ 348
Query: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
QPVQ+EL+ R QQLQSRL+TLKIENEEVKKT EATLQTIQD+VT+ED+DVS+CFQ+S S
Sbjct: 349 QPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRST 408
Query: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
ESVKSTVSET++SKPSIAKRRANQQETEQFYF K++EYLEG NLITKLQAKHDLLQ+TLG
Sbjct: 409 ESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLG 468
Query: 480 ESQRTDCSLAR-----------RSSTVRKQ---------------DSSQAIPLVVESCIR 513
E R + R R S R Q DS Q IPL+VESCIR
Sbjct: 469 EGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIR 528
Query: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
FI+ +GLQH+GIFRVSGSQVEVNDIKN+FERGE+PLA DQ++HD++S+AGVLKLYFRGLE
Sbjct: 529 FINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLE 588
Query: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
+PLFPK+ F+DL++C+ +DNL ERALHIRK+LL LP++ LI+MRYLFAFLNHLSQ+S+EN
Sbjct: 589 NPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDEN 648
Query: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRG 693
MMDPYNLAICFGP+LM VPE DQVSCQAHVNE+IKTIII HE IFP +EL+GPVY +
Sbjct: 649 MMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKC 708
Query: 694 GSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGA 753
+ +DYCDSP+ E ++E+ QD E HTS+DECEPIEAIAKFDYVGR+ARELSFKKGA
Sbjct: 709 MAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGA 768
Query: 754 SLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVT 813
SLLLY RAS+DWWEGRHNGIDGL+PHQYIVVQD +D + S K++ E S P E +
Sbjct: 769 SLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKS 828
Query: 814 ARAGASCPSGGHVADIYLANINKQRKRPE-SGSIRKTFRSDS--------HGLSSSLTDS 864
+ + P+ H D YLA +QRKR E +R+ R+ H LS+S D
Sbjct: 829 SSKDMNSPTDRH-PDGYLA---RQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDL 884
Query: 865 SSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTAT 924
SP + + R Q ++ L + P++ GHGSL +ISRH SLK ++DSP IR++ +
Sbjct: 885 GSPSLASHPRGLLQ---NRGLNNDSPERRRRPGHGSLTNISRHDSLK-KIDSPPIRRSTS 940
Query: 925 AGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSP 984
+G+ FN+H+P+DPE IAQDIE TMN+ALNELRELERQS+ KH PDVVLDTLE +K SP
Sbjct: 941 SGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSP 1000
Query: 985 VVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPT 1044
A ++E SPLH L+ EP +RS S++ D F+P+ + +M +KPPA RPKP
Sbjct: 1001 TPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPA 1060
Query: 1045 VFPKTNATSPGVNSSTSPQS-TDKSCTV 1071
V PKTN P + + PQ TDKSCT+
Sbjct: 1061 VLPKTN---PTIGPAPPPQGPTDKSCTM 1085
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo
sapiens]
Length = 1075
Score = 1246 bits (3223), Expect = 0.0
Identities = 646/1079 (59%), Positives = 823/1079 (76%), Gaps = 29/1079 (2%)
Query: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
M+S KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
Query: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
+NN+I R Q+SED RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
Query: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
LKEAEKQEEKQ KS D + N+ R E++ RRSSVKKIEKMKEKRQAKY
Sbjct: 181 LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229
Query: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
+ENKLK KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R RT+LSAE
Sbjct: 230 SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288
Query: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
NLE S+HEGLD IENAV+NLD+ SDK +M+M N VFCPP+KFEFQPHMGD Q+ AQ
Sbjct: 289 YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
Query: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
QPVQ+EL+ R QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S
Sbjct: 349 QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408
Query: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
ESVKS SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 409 ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468
Query: 480 ESQRTDC--SLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVND 537
E +R +C + RR++ R QDS QAIPLVVESCIR+I+ +GLQ +GIFRV GSQVEVND
Sbjct: 469 EGERAECGTTRGRRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVND 528
Query: 538 IKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQER 597
IKN+FERGEDPL DQN+ D++S+AGVLKLYFRGLE+PLFPK+ F DL++ + ++N ER
Sbjct: 529 IKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAER 588
Query: 598 ALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQ 657
I+++L+ LP+ +++MRYLFAFLNHLSQ+S+ENMMDPYNLAICFGP+LM +P+G D
Sbjct: 589 VHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDP 648
Query: 658 VSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR---GGSMEDYCDSPHGETTSVEDST 714
VSCQAH+NE+IKTIII HE IFPSPRELEGPVY + GG E+YCDSPH E ++++
Sbjct: 649 VSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGG--EEYCDSPHSEPGAIDEVD 706
Query: 715 QDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGID 774
D E HTSD+E E IEAIAKFDY+GR+ RELSFKKGASLLLY RAS+DWWEGRHNG+D
Sbjct: 707 HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 766
Query: 775 GLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PEEKVTARAGASCPSGGHVADIYLAN 833
GLIPHQYIVVQD +D + S K++ E S P ++K +++ P+ H++D
Sbjct: 767 GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT-EHISDYGFGG 825
Query: 834 I-NKQRKRPESGSI-RKTFRSDSHGLSSSLTDS-SSPGVGASCRPSSQPIMSQSLPKEGP 890
+ + R R + +I R+ D+H L S +P A+C S I E P
Sbjct: 826 VMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESP 885
Query: 891 DKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATM 950
+K ++ GS SI+ + K + +R T + R S +H+ ++ E +A+DIE TM
Sbjct: 886 EKRRMATFGSAGSIN-YPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTM 944
Query: 951 NSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQR 1010
++AL+ELRELERQ++VK PDVVLDTLEPLK P +SEP+SPLHT +++DP+ A +R
Sbjct: 945 STALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPV-SSEPASPLHTIVIRDPDAAMRR 1003
Query: 1011 SASTAGDIACAFRPVKSVKMA-APVKPPATRP-KPTVFPKTNATSPGVNSSTSPQSTDK 1067
S+S++ ++ F+P S ++A A ++PP RP +P V +++++S S + T+K
Sbjct: 1004 SSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEK 1062
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo
sapiens]
Length = 1099
Score = 1229 bits (3181), Expect = 0.0
Identities = 644/1103 (58%), Positives = 822/1103 (74%), Gaps = 53/1103 (4%)
Query: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
M+S KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
Query: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
+NN+I R Q+SED RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
Query: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
LKEAEKQEEKQ KS D + N+ R E++ RRSSVKKIEKMKEKRQAKY
Sbjct: 181 LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229
Query: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
+ENKLK KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R RT+LSAE
Sbjct: 230 SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288
Query: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
NLE S+HEGLD IENAV+NLD+ SDK +M+M N VFCPP+KFEFQPHMGD Q+ AQ
Sbjct: 289 YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
Query: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
QPVQ+EL+ R QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S
Sbjct: 349 QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408
Query: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
ESVKS SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 409 ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468
Query: 480 ESQRTDCSLAR------RSSTVRK--------------------QDSSQAIPLVVESCIR 513
E +R +C R + +R+ +DS QAIPLVVESCIR
Sbjct: 469 EGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIR 528
Query: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
+I+ +GLQ +GIFRV GSQVEVNDIKN+FERGEDPL DQN+ D++S+AGVLKLYFRGLE
Sbjct: 529 YINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLE 588
Query: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
+PLFPK+ F DL++ + ++N ER I+++L+ LP+ +++MRYLFAFLNHLSQ+S+EN
Sbjct: 589 NPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDEN 648
Query: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR- 692
MMDPYNLAICFGP+LM +P+G D VSCQAH+NE+IKTIII HE IFPSPRELEGPVY +
Sbjct: 649 MMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKC 708
Query: 693 --GGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFK 750
GG E+YCDSPH E ++++ D E HTSD+E E IEAIAKFDY+GR+ RELSFK
Sbjct: 709 MAGG--EEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFK 766
Query: 751 KGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PE 809
KGASLLLY RAS+DWWEGRHNG+DGLIPHQYIVVQD +D + S K++ E S P +
Sbjct: 767 KGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLD 826
Query: 810 EKVTARAGASCPSGGHVADIYLANI-NKQRKRPESGSI-RKTFRSDSHGLSSSLTDS-SS 866
+K +++ P+ H++D + + R R + +I R+ D+H L S +
Sbjct: 827 DKASSKNDLQSPT-EHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDT 885
Query: 867 PGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAG 926
P A+C S I E P+K ++ GS SI+ + K + +R T +
Sbjct: 886 PPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSIN-YPDKKALSEGHSMRSTCGST 944
Query: 927 RSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVV 986
R S +H+ ++ E +A+DIE TM++AL+ELRELERQ++VK PDVVLDTLEPLK P
Sbjct: 945 RHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGP 1004
Query: 987 APTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMA-APVKPPATRP-KPT 1044
+SEP+SPLHT +++DP+ A +RS+S++ ++ F+P S ++A A ++PP RP +P
Sbjct: 1005 V-SSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPV 1063
Query: 1045 VFPKTNATSPGVNSSTSPQSTDK 1067
V +++++S S + T+K
Sbjct: 1064 VQHRSSSSSSSGVGSPAVTPTEK 1086
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 737 bits (1903), Expect = 0.0
Identities = 380/825 (46%), Positives = 556/825 (67%), Gaps = 47/825 (5%)
Query: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
M + K ++++ + AEY+TQVKE+R QL+EQ++CL+ Q ELR +LLQ+L +F R++AE+E
Sbjct: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
Query: 61 MDYSRNLEKLAERFLAKT----RSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTL 116
++YSR LEKLAERF ++ S + Q F+K+ ++LSP++CW +LL +++SR+ L
Sbjct: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
Query: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
S++ + R ++ED GRL KKS+++ QQLQD+L++V++EL + KTY Y+ +S++
Sbjct: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
Query: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQ 236
A++KL+EAE+QEEK+ G+SV P +TA E +R+SS+KK ++ EKRQ
Sbjct: 181 AEAKLREAERQEEKRAGRSV----------PTTTAGAT-EAGPLRKSSLKKGGRLVEKRQ 229
Query: 237 AKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFL 296
AK+ E+KLK KARNEYLL+L + NA+V YY+HD+ DL+D CCD G+H +L + LR++
Sbjct: 230 AKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMD-CCDTGFHLALGQVLRSYT 288
Query: 297 SAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
+AE + S+ +GL ++E AVE LD DK +++E++ VFCPP++F++ PH GD +++
Sbjct: 289 AAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEI 348
Query: 357 CAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYS 416
C + ++ E++ R Q +QSRL IE EEV KT++ATLQ + ++V +D DV D FQ S
Sbjct: 349 CVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTS 408
Query: 417 NSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQK 476
S ES+KST S+ +RR QQETE FY TK++EYL GR+++ KLQAKH+ LQ+
Sbjct: 409 PSTESLKSTSSDP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQE 466
Query: 477 TLGESQRTDCSLARRSSTVRK--------------------------QDSSQAIPLVVES 510
L + + ++ T RK Q S Q +PLVVES
Sbjct: 467 ALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVES 526
Query: 511 CIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFR 570
CIRFI+ +GLQHEGIFRVSG+Q+ V++I++AFERGEDPL HD+DS+AGVLKLYFR
Sbjct: 527 CIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFR 586
Query: 571 GLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFS 630
LE PLFP D+F +L+A ++ ER H+ ++L LP L+++RYLF FLNHL+Q+S
Sbjct: 587 SLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYS 646
Query: 631 EENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVY 690
+ENMMDPYNLA+CFGP+L+ VP G D V+ Q VN+L++T+I+Q + +FP L GPVY
Sbjct: 647 DENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVY 706
Query: 691 SRGGSMEDYCDSPHGETTSV-EDSTQDVTAEHHTSDDECE-PIEAIAKFDYVGRTARELS 748
+ + + S+ D+ ++ AE +D+ E +EA+A F Y GRTA+ELS
Sbjct: 707 EKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELS 766
Query: 749 FKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVV-QDTEDGVV 792
F++G L L++RAS DWW G HNG+ GLIPH+YI + TE VV
Sbjct: 767 FRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVV 811
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 109 bits (273), Expect = 1e-23
Identities = 66/195 (33%), Positives = 106/195 (54%), Gaps = 9/195 (4%)
Query: 505 PLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGV 564
PL+VE C+ FI GL EG+FR+ G V D++++F+ GE PL + D+ ++A +
Sbjct: 173 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLF--DSTTDVHTVASL 230
Query: 565 LKLYFRGLEHPLFPKDIFHDLMACVTM--DNLQERALHIRKVLLVLPKTTLIIMRYLFAF 622
LKLY R L P+ P + D ++C + + E L + K + LP+ ++RY+ F
Sbjct: 231 LKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKF 290
Query: 623 LNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNELIKTIIIQHENIF 679
L+ + +S N M NLA FGP+++ P+ D V+ + V L+ +I +H +F
Sbjct: 291 LDEVQAYSNVNKMSVQNLATVFGPNILR-PQVEDPVTIMEGTSLVQHLMTVLIRKHSQLF 349
Query: 680 PSPRELEGPVYSRGG 694
+P EGP RGG
Sbjct: 350 TAPVP-EGPTSPRGG 363
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 106 bits (264), Expect = 1e-22
Identities = 64/188 (34%), Positives = 102/188 (54%), Gaps = 3/188 (1%)
Query: 493 STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
+T+ K ++Q P+VV+ CIR I GL+ EG++RVSG + D+K AF+R +
Sbjct: 280 TTLVKAHNTQR-PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADIS 338
Query: 553 QNDH-DMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKT 611
N + D++ I G LKLYFR L P+ D + + + N ER + +VL++LP
Sbjct: 339 ANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPA 398
Query: 612 TLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC-QAHVNELIKT 670
+RYL L ++ ++N M+ NL I FGP+LM PE + +LI
Sbjct: 399 HYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQ 458
Query: 671 IIIQHENI 678
I+I++E++
Sbjct: 459 ILIENEDV 466
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 106 bits (264), Expect = 1e-22
Identities = 64/188 (34%), Positives = 102/188 (54%), Gaps = 3/188 (1%)
Query: 493 STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
+T+ K ++Q P+VV+ CIR I GL+ EG++RVSG + D+K AF+R +
Sbjct: 144 TTLVKAHNTQR-PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADIS 202
Query: 553 QNDH-DMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKT 611
N + D++ I G LKLYFR L P+ D + + + N ER + +VL++LP
Sbjct: 203 ANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPA 262
Query: 612 TLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC-QAHVNELIKT 670
+RYL L ++ ++N M+ NL I FGP+LM PE + +LI
Sbjct: 263 HYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQ 322
Query: 671 IIIQHENI 678
I+I++E++
Sbjct: 323 ILIENEDV 330
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 105 bits (263), Expect = 2e-22
Identities = 64/200 (32%), Positives = 113/200 (56%), Gaps = 10/200 (5%)
Query: 494 TVR--KQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAG 551
TVR K+ ++ P++VE C+ FI + GL+ EG+FR+ G V ++++AF+ GE P +
Sbjct: 45 TVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP-SF 103
Query: 552 DQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERA--LHIRKVLLVLP 609
D N D+ ++A +LKLY R L P+ P + D ++C + + +E A + K + LP
Sbjct: 104 DSNT-DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLP 162
Query: 610 KTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNE 666
+++Y+ FL+ + +S N M NLA FGP+++ P+ D ++ V +
Sbjct: 163 VVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQ 221
Query: 667 LIKTIIIQHENIFPSPRELE 686
L+ +I +H+ +FP EL+
Sbjct: 222 LMSVMISKHDCLFPKDAELQ 241
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 105 bits (263), Expect = 2e-22
Identities = 64/200 (32%), Positives = 113/200 (56%), Gaps = 10/200 (5%)
Query: 494 TVR--KQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAG 551
TVR K+ ++ P++VE C+ FI + GL+ EG+FR+ G V ++++AF+ GE P +
Sbjct: 47 TVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP-SF 105
Query: 552 DQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERA--LHIRKVLLVLP 609
D N D+ ++A +LKLY R L P+ P + D ++C + + +E A + K + LP
Sbjct: 106 DSNT-DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLP 164
Query: 610 KTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNE 666
+++Y+ FL+ + +S N M NLA FGP+++ P+ D ++ V +
Sbjct: 165 VVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQ 223
Query: 667 LIKTIIIQHENIFPSPRELE 686
L+ +I +H+ +FP EL+
Sbjct: 224 LMSVMISKHDCLFPKDAELQ 243
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 105 bits (263), Expect = 2e-22
Identities = 64/200 (32%), Positives = 113/200 (56%), Gaps = 10/200 (5%)
Query: 494 TVR--KQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAG 551
TVR K+ ++ P++VE C+ FI + GL+ EG+FR+ G V ++++AF+ GE P +
Sbjct: 140 TVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP-SF 198
Query: 552 DQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERA--LHIRKVLLVLP 609
D N D+ ++A +LKLY R L P+ P + D ++C + + +E A + K + LP
Sbjct: 199 DSNT-DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLP 257
Query: 610 KTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNE 666
+++Y+ FL+ + +S N M NLA FGP+++ P+ D ++ V +
Sbjct: 258 VVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQ 316
Query: 667 LIKTIIIQHENIFPSPRELE 686
L+ +I +H+ +FP EL+
Sbjct: 317 LMSVMISKHDCLFPKDAELQ 336
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 105 bits (262), Expect = 2e-22
Identities = 60/190 (31%), Positives = 107/190 (56%), Gaps = 4/190 (2%)
Query: 501 SQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPL-AGDQNDHDMD 559
+Q +PL+V +C R + GL+ GI+RV G+ V+ ++ RG + D+ D++
Sbjct: 822 NQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLN 881
Query: 560 SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
I+ +LK +FR L PLF D ++D + +++ +ER +RK++ LP +++L
Sbjct: 882 VISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFL 941
Query: 620 FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGH--DQVSCQAHVNELIKTIIIQHEN 677
L ++ SE+N M+P NLA+ FGP+L+ E + D V+ ++++T +IQH +
Sbjct: 942 VGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVET-LIQHSD 1000
Query: 678 IFPSPRELEG 687
F S E +G
Sbjct: 1001 WFFSDEEDKG 1010
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/180 (35%), Positives = 96/180 (53%), Gaps = 10/180 (5%)
Query: 505 PLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFER-GEDPLAGDQNDHDMDSIAG 563
P+VV+ CIR I GL EG++RVSG + D+K AF+R GE D++ I G
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341
Query: 564 VLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFL 623
LKLYFR L PL D + + + + E+ + + L +LP +RYL A L
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401
Query: 624 NHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNE-----LIKTIIIQHENI 678
++ +EN+M+ NL I FGP+LM PE + A +N+ L+ ++I++E+I
Sbjct: 402 KRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALNDIRYQRLVVELLIKNEDI 457
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/180 (35%), Positives = 96/180 (53%), Gaps = 10/180 (5%)
Query: 505 PLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFER-GEDPLAGDQNDHDMDSIAG 563
P+VV+ CIR I GL EG++RVSG + D+K AF+R GE D++ I G
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315
Query: 564 VLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFL 623
LKLYFR L PL D + + + + E+ + + L +LP +RYL A L
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
Query: 624 NHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNE-----LIKTIIIQHENI 678
++ +EN+M+ NL I FGP+LM PE + A +N+ L+ ++I++E+I
Sbjct: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALNDIRYQRLVVELLIKNEDI 431
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 96.3 bits (238), Expect = 1e-19
Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 14/230 (6%)
Query: 453 KMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCI 512
K++++L+ R + L+ K + + G C+LA R + +P V+ CI
Sbjct: 302 KLRKFLQRRPTLQSLREKGYIKDQVFG------CALAALCERERSR-----VPRFVQQCI 350
Query: 513 RFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGL 572
R + GL +G++R+SG+ + ++ + E D D+ I G LKL+FR L
Sbjct: 351 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFREL 410
Query: 573 EHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEE 632
PLFP F +A + + + R+ +R ++ LP +R LF L + + E+
Sbjct: 411 PEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQ 470
Query: 633 NMMDPYNLAICFGPSLMSVPEGHDQVSCQAHV--NELIKTIIIQHENIFP 680
N M ++AI FGP+L+ PE + V N++++ I+ Q +IFP
Sbjct: 471 NRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQQCADIFP 519
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 96.3 bits (238), Expect = 1e-19
Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 14/230 (6%)
Query: 453 KMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCI 512
K++++L+ R + L+ K + + G C+LA R + +P V+ CI
Sbjct: 329 KLRKFLQRRPTLQSLREKGYIKDQVFG------CALAALCERERSR-----VPRFVQQCI 377
Query: 513 RFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGL 572
R + GL +G++R+SG+ + ++ + E D D+ I G LKL+FR L
Sbjct: 378 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFREL 437
Query: 573 EHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEE 632
PLFP F +A + + + R+ +R ++ LP +R LF L + + E+
Sbjct: 438 PEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQ 497
Query: 633 NMMDPYNLAICFGPSLMSVPEGHDQVSCQAHV--NELIKTIIIQHENIFP 680
N M ++AI FGP+L+ PE + V N++++ I+ Q +IFP
Sbjct: 498 NRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQQCADIFP 546
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 95.9 bits (237), Expect = 2e-19
Identities = 81/341 (23%), Positives = 159/341 (46%), Gaps = 29/341 (8%)
Query: 376 RLSTLKIE---NEEVKKTMEATLQTIQDI---------VTVEDFDVSDCFQYSNSMESVK 423
RL+T E E + M A ++TIQ+ VT D +Y+N M +
Sbjct: 1010 RLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAE 1069
Query: 424 S---------TVSETFM---SKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKH 471
++ +T + S+P + ++E+E+ +K + ++ T +
Sbjct: 1070 QLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSK-DDTSPPKDKGTWRKGIP 1128
Query: 472 DLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGS 531
+++KT + + R +++ IPL+V+ C + + GL++ GI+RV G+
Sbjct: 1129 SIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGN 1188
Query: 532 QVEVNDIKNAFERG-EDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVT 590
++ ++ +G D D D++ I+ +LK +FR L PLF D + D +
Sbjct: 1189 NAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANR 1248
Query: 591 MDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMS 650
++ +R +++++ LP+ +++L A L +++ SE+N M+P NLAI FGP+L+
Sbjct: 1249 KEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVR 1308
Query: 651 VPEGHDQVSCQAHVNELIKTI--IIQHENIFPSPRELEGPV 689
E + H+ + K + +IQH + F + E P+
Sbjct: 1309 TSE-DNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPL 1348
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 94.0 bits (232), Expect = 7e-19
Identities = 129/596 (21%), Positives = 235/596 (39%), Gaps = 82/596 (13%)
Query: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
SD YL++ P F + + +++ E + D++K N L S M+ Y S +
Sbjct: 9 SDCYLDS--PDF----RERLKCYEQELERTNKFIKDVIKDGNALISAMRNY------SSA 56
Query: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSV--------KKI 228
Q + + + IG ++ ++ S A + E ++ R V K +
Sbjct: 57 VQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPL 116
Query: 229 EKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASL 288
E + K Q +T+ + K + E +L D H S
Sbjct: 117 ENFR-KEQIGFTKERKKKFEKDGERFYSL----------------------LDRHLHLSS 153
Query: 289 NRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPH 348
+ A+L +++ +H ++ + V + + ++ N+ P + F
Sbjct: 154 KKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKF-----NIVEPVLAFLHSLF 208
Query: 349 MGDMASQLCAQQ--PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQT--IQDIVTV 404
+ + + Q P + +L Q ++ S+ + E EE+KK M+ QT + T+
Sbjct: 209 ISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTI 268
Query: 405 EDFDVSD--------CFQYSNSMESVKSTVSETFMSKPSIAK------------RRANQQ 444
E + + +Y E T++ T M + AK RR +
Sbjct: 269 EGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTES 328
Query: 445 ETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAI 504
++F F E E IT LQA + ++ E+ D S + KQ +
Sbjct: 329 IDKRFCFDI--ETNERPGTIT-LQALSEANRRLWMEAM--DGKEPIYHSPITKQQEMELN 383
Query: 505 PL---VVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD--QNDHDMD 559
+ V CI I G++ EG++R GS ++V + NAF + P D +D D+
Sbjct: 384 EVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIK 443
Query: 560 SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
+I LK Y R L P+ + +L++ DNL R I ++ LP+ ++ L
Sbjct: 444 TITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELL 503
Query: 620 FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQH 675
L ++ + S+EN+M P N+ + FGP+LM E ++ I+I+H
Sbjct: 504 IRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEH 559
>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
sapiens]
Length = 645
Score = 92.4 bits (228), Expect = 2e-18
Identities = 70/263 (26%), Positives = 116/263 (44%), Gaps = 13/263 (4%)
Query: 463 LITKLQAKHDLLQKTLGESQRTDCSL--ARRSSTVRKQDS--SQAIPLVVESCIRFISRH 518
L+ QA+ + K L T C + R TV + +P++VE C FI H
Sbjct: 131 LMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEH 190
Query: 519 GLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFP 578
G EGIFR+ G V +++AF+ GE P D D+ ++A +LKLY R L P+ P
Sbjct: 191 GRNEEGIFRLPGQDNLVKQLRDAFDAGERP--SFDRDTDVHTVASLLKLYLRDLPEPVVP 248
Query: 579 KDIFHDLMACVTMDNLQERAL--HIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMD 636
+ + C + N E + K L +LP+ ++ Y+ FL+ + N M
Sbjct: 249 WSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMS 308
Query: 637 PYNLAICFGPSLMSVPEGHDQVSCQA--HVNELIKTIIIQHENIFPSPRELEGPVYSRGG 694
NLA G +L+ V + + ++ +I HE +FP +++ S
Sbjct: 309 VDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP---LSPPA 365
Query: 695 SMEDYCDSPHGETTSVEDSTQDV 717
D +P ++ D+T+D+
Sbjct: 366 QKNDPKKAPVARSSVGWDATEDL 388
>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
sapiens]
Length = 638
Score = 92.4 bits (228), Expect = 2e-18
Identities = 70/263 (26%), Positives = 116/263 (44%), Gaps = 13/263 (4%)
Query: 463 LITKLQAKHDLLQKTLGESQRTDCSL--ARRSSTVRKQDS--SQAIPLVVESCIRFISRH 518
L+ QA+ + K L T C + R TV + +P++VE C FI H
Sbjct: 124 LMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEH 183
Query: 519 GLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFP 578
G EGIFR+ G V +++AF+ GE P D D+ ++A +LKLY R L P+ P
Sbjct: 184 GRNEEGIFRLPGQDNLVKQLRDAFDAGERP--SFDRDTDVHTVASLLKLYLRDLPEPVVP 241
Query: 579 KDIFHDLMACVTMDNLQERAL--HIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMD 636
+ + C + N E + K L +LP+ ++ Y+ FL+ + N M
Sbjct: 242 WSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMS 301
Query: 637 PYNLAICFGPSLMSVPEGHDQVSCQA--HVNELIKTIIIQHENIFPSPRELEGPVYSRGG 694
NLA G +L+ V + + ++ +I HE +FP +++ S
Sbjct: 302 VDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP---LSPPA 358
Query: 695 SMEDYCDSPHGETTSVEDSTQDV 717
D +P ++ D+T+D+
Sbjct: 359 QKNDPKKAPVARSSVGWDATEDL 381
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 92.0 bits (227), Expect = 3e-18
Identities = 47/146 (32%), Positives = 88/146 (60%), Gaps = 1/146 (0%)
Query: 504 IPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAG 563
IP+ +E CI +I GL EGI+RVSG++ E+ ++ F++ + L + D ++++AG
Sbjct: 1261 IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHN-LDLAEKDFTVNTVAG 1319
Query: 564 VLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFL 623
+K +F L PL P ++ DL+ +++ +++ +++VL PK + +Y+ + L
Sbjct: 1320 AMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHL 1379
Query: 624 NHLSQFSEENMMDPYNLAICFGPSLM 649
N +S ++ N+M NL+ICF P+LM
Sbjct: 1380 NKVSHNNKVNLMTSENLSICFWPTLM 1405
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 92.0 bits (227), Expect = 3e-18
Identities = 49/161 (30%), Positives = 88/161 (54%), Gaps = 1/161 (0%)
Query: 493 STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
+ V K++ S+ +P +V C+ I R G++ GI+RVSG ++ +K AF+ ++
Sbjct: 1013 AVVTKRERSK-VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVM 1071
Query: 553 QNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTT 612
++ D+++IAG LKLYFR L PLF + + + + + + + + +LL LP+
Sbjct: 1072 MSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEAN 1131
Query: 613 LIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPE 653
L+ +L L +++ N M +NLA FGP+L+ E
Sbjct: 1132 LLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1172
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 92.0 bits (227), Expect = 3e-18
Identities = 49/161 (30%), Positives = 88/161 (54%), Gaps = 1/161 (0%)
Query: 493 STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
+ V K++ S+ +P +V C+ I R G++ GI+RVSG ++ +K AF+ ++
Sbjct: 1057 AVVTKRERSK-VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVM 1115
Query: 553 QNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTT 612
++ D+++IAG LKLYFR L PLF + + + + + + + + +LL LP+
Sbjct: 1116 MSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEAN 1175
Query: 613 LIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPE 653
L+ +L L +++ N M +NLA FGP+L+ E
Sbjct: 1176 LLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 91.7 bits (226), Expect = 3e-18
Identities = 57/227 (25%), Positives = 110/227 (48%), Gaps = 13/227 (5%)
Query: 454 MKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIR 513
+K++L R + ++ K + + G + C Q + +P V+ CI
Sbjct: 630 LKKFLTRRPTLQAVREKGYIKDQVFGSNLANLC-----------QRENGTVPKFVKLCIE 678
Query: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
+ HGL +GI+RVSG+ + ++ A E D D+ I G LK++FR L
Sbjct: 679 HVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELP 738
Query: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
PLF + F+D + + + ++R ++ ++ LPK M+ LF L + + E+N
Sbjct: 739 EPLFTFNHFNDFVNAIKQEP-RQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKN 797
Query: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQ-AHVNELIKTIIIQHENIF 679
M ++AI FGP+L+ + ++ + N++++ I+++ +IF
Sbjct: 798 RMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIF 844
Score = 30.8 bits (68), Expect = 7.1
Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 3/54 (5%)
Query: 731 IEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGR--HNGIDGLIPHQYI 782
IE ++Y + R++ K+G +L ++ +DDWW+ + N +P QY+
Sbjct: 17 IEVEYDYEYEAKD-RKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYV 69
>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
Length = 740
Score = 89.0 bits (219), Expect = 2e-17
Identities = 92/344 (26%), Positives = 148/344 (43%), Gaps = 52/344 (15%)
Query: 22 KEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRST 81
+E++ EQM L + + LL+D++ F +KKA IE +Y++ ++KLA ++L +
Sbjct: 12 QELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPG 71
Query: 82 KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKK 141
+ D + PV W L + ++ + + Y N I + R +
Sbjct: 72 VKADDRNDYRSMYPV--WKSFLEGTMQVAQSRMNICENYKNFI--------SEPARTVRS 121
Query: 142 SKEVGQQLQ---DDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQ 198
KE QQL+ D L K+ EL +K D + K E E Q+ +V++
Sbjct: 122 LKE--QQLKRCVDQLTKIQTELQETVK-------DLAKGKKKYFETE-----QMAHAVRE 167
Query: 199 EDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALE 258
+ A++ + K S ++K K +A+ +E KA ARN+YLL L
Sbjct: 168 K-----------ADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLA 216
Query: 259 ATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVE 318
A NA +YY DL +++ + D + L L F EL E A++N +
Sbjct: 217 AANAHQDRYYQTDLVNIM-KALDGNVYDHLKDYLIAFSRTEL-------ETCQAVQNTFQ 268
Query: 319 NLDATSDK------QRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
L S K +L N VF P F+FQP D + QL
Sbjct: 269 FLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQL 312
Score = 38.5 bits (88), Expect = 0.034
Identities = 19/47 (40%), Positives = 28/47 (59%), Gaps = 3/47 (6%)
Query: 735 AKFDYVGRTARELSFKKGASLLLYQRASDD---WWEGRHNGIDGLIP 778
A +DY G+T ELSF +GA + + + + D +WEG NG G+ P
Sbjct: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP 620
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 88.6 bits (218), Expect = 3e-17
Identities = 57/234 (24%), Positives = 106/234 (45%), Gaps = 12/234 (5%)
Query: 452 TKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESC 511
+++K+++ R + LQ K + + G C R +STV P V+ C
Sbjct: 253 SRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCE--RENSTV---------PWFVKQC 301
Query: 512 IRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRG 571
I + + GL +GI+RVSG+ + ++ + E D D+ + G LK++FR
Sbjct: 302 IEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRE 361
Query: 572 LEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSE 631
L PLFP F + + + R ++ ++ LP M+ LF L + +
Sbjct: 362 LPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKAS 421
Query: 632 ENMMDPYNLAICFGPSLMSVP-EGHDQVSCQAHVNELIKTIIIQHENIFPSPRE 684
+N+M +L I FGP+L+ E + + N++ + ++ ++ IF S +
Sbjct: 422 KNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED 475
>gi|89886350 Rho GTPase activating protein 11B [Homo sapiens]
Length = 267
Score = 88.2 bits (217), Expect = 4e-17
Identities = 54/165 (32%), Positives = 89/165 (53%), Gaps = 7/165 (4%)
Query: 507 VVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLK 566
+V++C + H + EG+FR SGS + + +KN + GE G + IAG+LK
Sbjct: 69 LVDACTS-LEEH-IHTEGLFRKSGSVIRLKALKNKVDHGE----GCLSSAPPCDIAGLLK 122
Query: 567 LYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHL 626
+FR L P+ P D+ H+ + +E+ I + +L T+ ++RY F FL ++
Sbjct: 123 QFFRELPEPILPADL-HEALLKAQQLGTEEKNKAILLLSCLLADHTVHVLRYFFNFLRNV 181
Query: 627 SQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTI 671
S S EN MD NLA+ F P+L+ EGH+++S A + +T+
Sbjct: 182 SLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAEKKGVYQTL 226
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 88.2 bits (217), Expect = 4e-17
Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 498 QDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHD 557
Q+ + I L +E+C+ + G++ EG+FR++ + +K DP + ++ D
Sbjct: 283 QELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTM--ASDPHSLEEFCSD 340
Query: 558 MDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMR 617
++AG LK Y R L PL D++ D M ++ R +++V LP L +R
Sbjct: 341 PHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLR 400
Query: 618 YLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGH-DQVSCQA------HVNELIKT 670
YL FL L++ E N M P N+AI GP+L+ PE DQ A V +++
Sbjct: 401 YLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEA 460
Query: 671 IIIQHENIFP 680
+I + +FP
Sbjct: 461 LIQSADTLFP 470
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 87.0 bits (214), Expect = 8e-17
Identities = 52/181 (28%), Positives = 96/181 (53%), Gaps = 2/181 (1%)
Query: 500 SSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMD 559
+ + IPL VE C+ FI GL EG++RVSG++ + ++I+ F++ + + + ++
Sbjct: 1270 AEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHN-INLVSMEVTVN 1328
Query: 560 SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
++AG LK +F L PL P + +L+ + + ER +++++ + RY+
Sbjct: 1329 AVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYV 1388
Query: 620 FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVP-EGHDQVSCQAHVNELIKTIIIQHENI 678
LN +SQ + N+M NL+ICF P+LM E + +S +++T I Q +
Sbjct: 1389 ITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFF 1448
Query: 679 F 679
F
Sbjct: 1449 F 1449
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,085,965
Number of Sequences: 37866
Number of extensions: 1791457
Number of successful extensions: 9079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 251
Number of HSP's successfully gapped in prelim test: 428
Number of HSP's that attempted gapping in prelim test: 7563
Number of HSP's gapped (non-prelim): 1691
length of query: 1071
length of database: 18,247,518
effective HSP length: 113
effective length of query: 958
effective length of database: 13,968,660
effective search space: 13381976280
effective search space used: 13381976280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.