Guide to the Human Genome
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Search of human proteins with 112363100

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform
a [Homo sapiens]
         (1071 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a...  2125   0.0  
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b...  1662   0.0  
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi...  1417   0.0  
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ...  1246   0.0  
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ...  1229   0.0  
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]           737   0.0  
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]            109   1e-23
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     106   1e-22
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    106   1e-22
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa...   105   2e-22
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa...   105   2e-22
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...   105   2e-22
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          105   2e-22
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            100   1e-20
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          100   1e-20
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...    96   1e-19
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...    96   1e-19
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           96   2e-19
gi|4505507 oligophrenin 1 [Homo sapiens]                               94   7e-19
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap...    92   2e-18
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi...    92   2e-18
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ...    92   3e-18
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]         92   3e-18
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]         92   3e-18
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]            92   3e-18
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]               89   2e-17
gi|188497642 ARHGAP15 [Homo sapiens]                                   89   3e-17
gi|89886350 Rho GTPase activating protein 11B [Homo sapiens]           88   4e-17
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]                88   4e-17
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi...    87   8e-17

>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
            [Homo sapiens]
          Length = 1071

 Score = 2125 bits (5507), Expect = 0.0
 Identities = 1071/1071 (100%), Positives = 1071/1071 (100%)

Query: 1    MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
            MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE
Sbjct: 1    MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60

Query: 61   MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
            MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY
Sbjct: 61   MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120

Query: 121  LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
            LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK
Sbjct: 121  LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180

Query: 181  LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240
            LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT
Sbjct: 181  LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240

Query: 241  ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300
            ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL
Sbjct: 241  ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300

Query: 301  NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360
            NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ
Sbjct: 301  NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360

Query: 361  PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420
            PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME
Sbjct: 361  PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420

Query: 421  SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480
            SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE
Sbjct: 421  SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480

Query: 481  SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540
            SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN
Sbjct: 481  SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540

Query: 541  AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600
            AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH
Sbjct: 541  AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600

Query: 601  IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660
            IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC
Sbjct: 601  IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660

Query: 661  QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720
            QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE
Sbjct: 661  QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720

Query: 721  HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780
            HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ
Sbjct: 721  HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780

Query: 781  YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR 840
            YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR
Sbjct: 781  YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR 840

Query: 841  PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS 900
            PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS
Sbjct: 841  PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS 900

Query: 901  LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL 960
            LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL
Sbjct: 901  LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL 960

Query: 961  ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC 1020
            ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC
Sbjct: 961  ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC 1020

Query: 1021 AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV 1071
            AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV
Sbjct: 1021 AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV 1071


>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
           [Homo sapiens]
          Length = 836

 Score = 1662 bits (4305), Expect = 0.0
 Identities = 836/836 (100%), Positives = 836/836 (100%)

Query: 1   MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
           MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE
Sbjct: 1   MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60

Query: 61  MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
           MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY
Sbjct: 61  MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120

Query: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
           LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK
Sbjct: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180

Query: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240
           LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT
Sbjct: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT 240

Query: 241 ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300
           ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL
Sbjct: 241 ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL 300

Query: 301 NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360
           NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ
Sbjct: 301 NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ 360

Query: 361 PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420
           PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME
Sbjct: 361 PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME 420

Query: 421 SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480
           SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE
Sbjct: 421 SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE 480

Query: 481 SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540
           SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN
Sbjct: 481 SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN 540

Query: 541 AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600
           AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH
Sbjct: 541 AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH 600

Query: 601 IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660
           IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC
Sbjct: 601 IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC 660

Query: 661 QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720
           QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE
Sbjct: 661 QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE 720

Query: 721 HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780
           HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ
Sbjct: 721 HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ 780

Query: 781 YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINK 836
           YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINK
Sbjct: 781 YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINK 836


>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
          Length = 1085

 Score = 1417 bits (3667), Expect = 0.0
 Identities = 736/1108 (66%), Positives = 872/1108 (78%), Gaps = 60/1108 (5%)

Query: 1    MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
            M++P++FKKDKEIIAEY++QVKEIRAQL EQ KCL+QQ E+RVQLLQDLQDFFRKKAEIE
Sbjct: 1    MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60

Query: 61   MDYSRNLEKLAERFLAKTRSTKD-QQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDI 119
             +YSRNLEKLAERF+AKTRSTKD QQ+KKDQN+LSPVNCW LLLNQV+RES+DH TLSDI
Sbjct: 61   TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120

Query: 120  YLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQS 179
            YLNN+I RF+Q+SEDS R+FKKSKE+  QL +DLMKVLNELY+VMKTYHMY+A+SISA+S
Sbjct: 121  YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180

Query: 180  KLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKY 239
            KLKEAEKQEEKQIG           RS D   ++R+EE+H RRSSVKKIEKMKEKRQAKY
Sbjct: 181  KLKEAEKQEEKQIG-----------RSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKY 229

Query: 240  TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
            +ENKLK+IKARNEYLL LEATNASVFKYYIHDLSDLID CCDLGYHASLNRALRT+LSAE
Sbjct: 230  SENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLID-CCDLGYHASLNRALRTYLSAE 288

Query: 300  LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
             NLE S+HEGLD IENAV+NL+  SDKQR MEMY   FCPPMKFEFQ HMGD   Q+ AQ
Sbjct: 289  YNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQ 348

Query: 360  QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
            QPVQ+EL+ R QQLQSRL+TLKIENEEVKKT EATLQTIQD+VT+ED+DVS+CFQ+S S 
Sbjct: 349  QPVQAELMLRYQQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRST 408

Query: 420  ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
            ESVKSTVSET++SKPSIAKRRANQQETEQFYF K++EYLEG NLITKLQAKHDLLQ+TLG
Sbjct: 409  ESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLG 468

Query: 480  ESQRTDCSLAR-----------RSSTVRKQ---------------DSSQAIPLVVESCIR 513
            E  R +    R           R S  R Q               DS Q IPL+VESCIR
Sbjct: 469  EGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIR 528

Query: 514  FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
            FI+ +GLQH+GIFRVSGSQVEVNDIKN+FERGE+PLA DQ++HD++S+AGVLKLYFRGLE
Sbjct: 529  FINLYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLE 588

Query: 574  HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
            +PLFPK+ F+DL++C+ +DNL ERALHIRK+LL LP++ LI+MRYLFAFLNHLSQ+S+EN
Sbjct: 589  NPLFPKERFNDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDEN 648

Query: 634  MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRG 693
            MMDPYNLAICFGP+LM VPE  DQVSCQAHVNE+IKTIII HE IFP  +EL+GPVY + 
Sbjct: 649  MMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKC 708

Query: 694  GSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGA 753
             + +DYCDSP+ E  ++E+  QD   E HTS+DECEPIEAIAKFDYVGR+ARELSFKKGA
Sbjct: 709  MAGDDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGA 768

Query: 754  SLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVT 813
            SLLLY RAS+DWWEGRHNGIDGL+PHQYIVVQD +D   +  S K++ E  S P  E  +
Sbjct: 769  SLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKS 828

Query: 814  ARAGASCPSGGHVADIYLANINKQRKRPE-SGSIRKTFRSDS--------HGLSSSLTDS 864
            +    + P+  H  D YLA   +QRKR E    +R+  R+          H LS+S  D 
Sbjct: 829  SSKDMNSPTDRH-PDGYLA---RQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDL 884

Query: 865  SSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTAT 924
             SP + +  R   Q   ++ L  + P++    GHGSL +ISRH SLK ++DSP IR++ +
Sbjct: 885  GSPSLASHPRGLLQ---NRGLNNDSPERRRRPGHGSLTNISRHDSLK-KIDSPPIRRSTS 940

Query: 925  AGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSP 984
            +G+   FN+H+P+DPE IAQDIE TMN+ALNELRELERQS+ KH PDVVLDTLE +K SP
Sbjct: 941  SGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSP 1000

Query: 985  VVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPT 1044
              A ++E  SPLH   L+  EP  +RS S++ D    F+P+ + +M   +KPPA RPKP 
Sbjct: 1001 TPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPA 1060

Query: 1045 VFPKTNATSPGVNSSTSPQS-TDKSCTV 1071
            V PKTN   P +  +  PQ  TDKSCT+
Sbjct: 1061 VLPKTN---PTIGPAPPPQGPTDKSCTM 1085


>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo
            sapiens]
          Length = 1075

 Score = 1246 bits (3223), Expect = 0.0
 Identities = 646/1079 (59%), Positives = 823/1079 (76%), Gaps = 29/1079 (2%)

Query: 1    MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
            M+S  KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1    MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60

Query: 61   MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
            ++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61   LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120

Query: 121  LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
            +NN+I R  Q+SED  RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121  MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180

Query: 181  LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
            LKEAEKQEEKQ  KS            D + N+ R E++  RRSSVKKIEKMKEKRQAKY
Sbjct: 181  LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229

Query: 240  TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
            +ENKLK  KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R  RT+LSAE
Sbjct: 230  SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288

Query: 300  LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
             NLE S+HEGLD IENAV+NLD+ SDK  +M+M N VFCPP+KFEFQPHMGD   Q+ AQ
Sbjct: 289  YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348

Query: 360  QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
            QPVQ+EL+ R  QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S 
Sbjct: 349  QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408

Query: 420  ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
            ESVKS  SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 409  ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468

Query: 480  ESQRTDC--SLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVND 537
            E +R +C  +  RR++  R QDS QAIPLVVESCIR+I+ +GLQ +GIFRV GSQVEVND
Sbjct: 469  EGERAECGTTRGRRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVND 528

Query: 538  IKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQER 597
            IKN+FERGEDPL  DQN+ D++S+AGVLKLYFRGLE+PLFPK+ F DL++ + ++N  ER
Sbjct: 529  IKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAER 588

Query: 598  ALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQ 657
               I+++L+ LP+  +++MRYLFAFLNHLSQ+S+ENMMDPYNLAICFGP+LM +P+G D 
Sbjct: 589  VHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDP 648

Query: 658  VSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR---GGSMEDYCDSPHGETTSVEDST 714
            VSCQAH+NE+IKTIII HE IFPSPRELEGPVY +   GG  E+YCDSPH E  ++++  
Sbjct: 649  VSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGG--EEYCDSPHSEPGAIDEVD 706

Query: 715  QDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGID 774
             D   E HTSD+E E IEAIAKFDY+GR+ RELSFKKGASLLLY RAS+DWWEGRHNG+D
Sbjct: 707  HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 766

Query: 775  GLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PEEKVTARAGASCPSGGHVADIYLAN 833
            GLIPHQYIVVQD +D   +  S K++ E  S P  ++K +++     P+  H++D     
Sbjct: 767  GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT-EHISDYGFGG 825

Query: 834  I-NKQRKRPESGSI-RKTFRSDSHGLSSSLTDS-SSPGVGASCRPSSQPIMSQSLPKEGP 890
            +  + R R +  +I R+    D+H     L  S  +P   A+C  S   I       E P
Sbjct: 826  VMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESP 885

Query: 891  DKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATM 950
            +K  ++  GS  SI+ +   K   +   +R T  + R  S  +H+ ++ E +A+DIE TM
Sbjct: 886  EKRRMATFGSAGSIN-YPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTM 944

Query: 951  NSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQR 1010
            ++AL+ELRELERQ++VK  PDVVLDTLEPLK  P    +SEP+SPLHT +++DP+ A +R
Sbjct: 945  STALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPV-SSEPASPLHTIVIRDPDAAMRR 1003

Query: 1011 SASTAGDIACAFRPVKSVKMA-APVKPPATRP-KPTVFPKTNATSPGVNSSTSPQSTDK 1067
            S+S++ ++   F+P  S ++A A ++PP  RP +P V  +++++S     S +   T+K
Sbjct: 1004 SSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEK 1062


>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo
            sapiens]
          Length = 1099

 Score = 1229 bits (3181), Expect = 0.0
 Identities = 644/1103 (58%), Positives = 822/1103 (74%), Gaps = 53/1103 (4%)

Query: 1    MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
            M+S  KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1    MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60

Query: 61   MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
            ++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61   LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120

Query: 121  LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
            +NN+I R  Q+SED  RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121  MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180

Query: 181  LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
            LKEAEKQEEKQ  KS            D + N+ R E++  RRSSVKKIEKMKEKRQAKY
Sbjct: 181  LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229

Query: 240  TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
            +ENKLK  KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R  RT+LSAE
Sbjct: 230  SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288

Query: 300  LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
             NLE S+HEGLD IENAV+NLD+ SDK  +M+M N VFCPP+KFEFQPHMGD   Q+ AQ
Sbjct: 289  YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348

Query: 360  QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
            QPVQ+EL+ R  QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S 
Sbjct: 349  QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408

Query: 420  ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
            ESVKS  SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 409  ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468

Query: 480  ESQRTDCSLAR------RSSTVRK--------------------QDSSQAIPLVVESCIR 513
            E +R +C   R      +   +R+                    +DS QAIPLVVESCIR
Sbjct: 469  EGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIR 528

Query: 514  FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
            +I+ +GLQ +GIFRV GSQVEVNDIKN+FERGEDPL  DQN+ D++S+AGVLKLYFRGLE
Sbjct: 529  YINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLE 588

Query: 574  HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
            +PLFPK+ F DL++ + ++N  ER   I+++L+ LP+  +++MRYLFAFLNHLSQ+S+EN
Sbjct: 589  NPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDEN 648

Query: 634  MMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR- 692
            MMDPYNLAICFGP+LM +P+G D VSCQAH+NE+IKTIII HE IFPSPRELEGPVY + 
Sbjct: 649  MMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKC 708

Query: 693  --GGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFK 750
              GG  E+YCDSPH E  ++++   D   E HTSD+E E IEAIAKFDY+GR+ RELSFK
Sbjct: 709  MAGG--EEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFK 766

Query: 751  KGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PE 809
            KGASLLLY RAS+DWWEGRHNG+DGLIPHQYIVVQD +D   +  S K++ E  S P  +
Sbjct: 767  KGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLD 826

Query: 810  EKVTARAGASCPSGGHVADIYLANI-NKQRKRPESGSI-RKTFRSDSHGLSSSLTDS-SS 866
            +K +++     P+  H++D     +  + R R +  +I R+    D+H     L  S  +
Sbjct: 827  DKASSKNDLQSPT-EHISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDT 885

Query: 867  PGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAG 926
            P   A+C  S   I       E P+K  ++  GS  SI+ +   K   +   +R T  + 
Sbjct: 886  PPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSIN-YPDKKALSEGHSMRSTCGST 944

Query: 927  RSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVV 986
            R  S  +H+ ++ E +A+DIE TM++AL+ELRELERQ++VK  PDVVLDTLEPLK  P  
Sbjct: 945  RHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGP 1004

Query: 987  APTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMA-APVKPPATRP-KPT 1044
              +SEP+SPLHT +++DP+ A +RS+S++ ++   F+P  S ++A A ++PP  RP +P 
Sbjct: 1005 V-SSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPV 1063

Query: 1045 VFPKTNATSPGVNSSTSPQSTDK 1067
            V  +++++S     S +   T+K
Sbjct: 1064 VQHRSSSSSSSGVGSPAVTPTEK 1086


>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
          Length = 946

 Score =  737 bits (1903), Expect = 0.0
 Identities = 380/825 (46%), Positives = 556/825 (67%), Gaps = 47/825 (5%)

Query: 1   MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
           M +  K ++++ + AEY+TQVKE+R QL+EQ++CL+ Q ELR +LLQ+L +F R++AE+E
Sbjct: 1   MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60

Query: 61  MDYSRNLEKLAERFLAKT----RSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTL 116
           ++YSR LEKLAERF ++      S + Q F+K+ ++LSP++CW +LL   +++SR+   L
Sbjct: 61  LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120

Query: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
           S++    +  R   ++ED GRL KKS+++ QQLQD+L++V++EL +  KTY  Y+ +S++
Sbjct: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180

Query: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQ 236
           A++KL+EAE+QEEK+ G+SV          P +TA    E   +R+SS+KK  ++ EKRQ
Sbjct: 181 AEAKLREAERQEEKRAGRSV----------PTTTAGAT-EAGPLRKSSLKKGGRLVEKRQ 229

Query: 237 AKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFL 296
           AK+ E+KLK  KARNEYLL+L + NA+V  YY+HD+ DL+D CCD G+H +L + LR++ 
Sbjct: 230 AKFMEHKLKCTKARNEYLLSLASVNAAVSNYYLHDVLDLMD-CCDTGFHLALGQVLRSYT 288

Query: 297 SAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
           +AE   + S+ +GL ++E AVE LD   DK +++E++  VFCPP++F++ PH GD  +++
Sbjct: 289 AAESRTQASQVQGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEI 348

Query: 357 CAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYS 416
           C +  ++ E++ R Q +QSRL    IE EEV KT++ATLQ + ++V  +D DV D FQ S
Sbjct: 349 CVEMELRDEILPRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTS 408

Query: 417 NSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQK 476
            S ES+KST S+         +RR  QQETE FY TK++EYL GR+++ KLQAKH+ LQ+
Sbjct: 409 PSTESLKSTSSDP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQE 466

Query: 477 TLGESQRTDCSLARRSSTVRK--------------------------QDSSQAIPLVVES 510
            L    + +  ++    T RK                          Q S Q +PLVVES
Sbjct: 467 ALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVES 526

Query: 511 CIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFR 570
           CIRFI+ +GLQHEGIFRVSG+Q+ V++I++AFERGEDPL      HD+DS+AGVLKLYFR
Sbjct: 527 CIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFR 586

Query: 571 GLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFS 630
            LE PLFP D+F +L+A   ++   ER  H+ ++L  LP   L+++RYLF FLNHL+Q+S
Sbjct: 587 SLEPPLFPPDLFGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYS 646

Query: 631 EENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVY 690
           +ENMMDPYNLA+CFGP+L+ VP G D V+ Q  VN+L++T+I+Q + +FP    L GPVY
Sbjct: 647 DENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVY 706

Query: 691 SRGGSMEDYCDSPHGETTSV-EDSTQDVTAEHHTSDDECE-PIEAIAKFDYVGRTARELS 748
            +  +          +  S+  D+  ++ AE    +D+ E  +EA+A F Y GRTA+ELS
Sbjct: 707 EKCMAPPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELS 766

Query: 749 FKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVV-QDTEDGVV 792
           F++G  L L++RAS DWW G HNG+ GLIPH+YI +   TE  VV
Sbjct: 767 FRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYITLPAGTEKQVV 811


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score =  109 bits (273), Expect = 1e-23
 Identities = 66/195 (33%), Positives = 106/195 (54%), Gaps = 9/195 (4%)

Query: 505 PLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGV 564
           PL+VE C+ FI   GL  EG+FR+ G    V D++++F+ GE PL    +  D+ ++A +
Sbjct: 173 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLF--DSTTDVHTVASL 230

Query: 565 LKLYFRGLEHPLFPKDIFHDLMACVTM--DNLQERALHIRKVLLVLPKTTLIIMRYLFAF 622
           LKLY R L  P+ P   + D ++C  +   +  E  L + K +  LP+    ++RY+  F
Sbjct: 231 LKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKF 290

Query: 623 LNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNELIKTIIIQHENIF 679
           L+ +  +S  N M   NLA  FGP+++  P+  D V+     + V  L+  +I +H  +F
Sbjct: 291 LDEVQAYSNVNKMSVQNLATVFGPNILR-PQVEDPVTIMEGTSLVQHLMTVLIRKHSQLF 349

Query: 680 PSPRELEGPVYSRGG 694
            +P   EGP   RGG
Sbjct: 350 TAPVP-EGPTSPRGG 363


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  106 bits (264), Expect = 1e-22
 Identities = 64/188 (34%), Positives = 102/188 (54%), Gaps = 3/188 (1%)

Query: 493 STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
           +T+ K  ++Q  P+VV+ CIR I   GL+ EG++RVSG    + D+K AF+R  +     
Sbjct: 280 TTLVKAHNTQR-PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADIS 338

Query: 553 QNDH-DMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKT 611
            N + D++ I G LKLYFR L  P+   D +   +    + N  ER   + +VL++LP  
Sbjct: 339 ANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPA 398

Query: 612 TLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC-QAHVNELIKT 670
               +RYL   L  ++   ++N M+  NL I FGP+LM  PE     +       +LI  
Sbjct: 399 HYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQ 458

Query: 671 IIIQHENI 678
           I+I++E++
Sbjct: 459 ILIENEDV 466


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  106 bits (264), Expect = 1e-22
 Identities = 64/188 (34%), Positives = 102/188 (54%), Gaps = 3/188 (1%)

Query: 493 STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
           +T+ K  ++Q  P+VV+ CIR I   GL+ EG++RVSG    + D+K AF+R  +     
Sbjct: 144 TTLVKAHNTQR-PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADIS 202

Query: 553 QNDH-DMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKT 611
            N + D++ I G LKLYFR L  P+   D +   +    + N  ER   + +VL++LP  
Sbjct: 203 ANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPA 262

Query: 612 TLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC-QAHVNELIKT 670
               +RYL   L  ++   ++N M+  NL I FGP+LM  PE     +       +LI  
Sbjct: 263 HYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQ 322

Query: 671 IIIQHENI 678
           I+I++E++
Sbjct: 323 ILIENEDV 330


>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
           sapiens]
          Length = 653

 Score =  105 bits (263), Expect = 2e-22
 Identities = 64/200 (32%), Positives = 113/200 (56%), Gaps = 10/200 (5%)

Query: 494 TVR--KQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAG 551
           TVR  K+  ++  P++VE C+ FI + GL+ EG+FR+ G    V ++++AF+ GE P + 
Sbjct: 45  TVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP-SF 103

Query: 552 DQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERA--LHIRKVLLVLP 609
           D N  D+ ++A +LKLY R L  P+ P   + D ++C  + + +E A    + K +  LP
Sbjct: 104 DSNT-DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLP 162

Query: 610 KTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNE 666
                +++Y+  FL+ +  +S  N M   NLA  FGP+++  P+  D ++       V +
Sbjct: 163 VVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQ 221

Query: 667 LIKTIIIQHENIFPSPRELE 686
           L+  +I +H+ +FP   EL+
Sbjct: 222 LMSVMISKHDCLFPKDAELQ 241


>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
           sapiens]
          Length = 655

 Score =  105 bits (263), Expect = 2e-22
 Identities = 64/200 (32%), Positives = 113/200 (56%), Gaps = 10/200 (5%)

Query: 494 TVR--KQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAG 551
           TVR  K+  ++  P++VE C+ FI + GL+ EG+FR+ G    V ++++AF+ GE P + 
Sbjct: 47  TVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP-SF 105

Query: 552 DQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERA--LHIRKVLLVLP 609
           D N  D+ ++A +LKLY R L  P+ P   + D ++C  + + +E A    + K +  LP
Sbjct: 106 DSNT-DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLP 164

Query: 610 KTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNE 666
                +++Y+  FL+ +  +S  N M   NLA  FGP+++  P+  D ++       V +
Sbjct: 165 VVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQ 223

Query: 667 LIKTIIIQHENIFPSPRELE 686
           L+  +I +H+ +FP   EL+
Sbjct: 224 LMSVMISKHDCLFPKDAELQ 243


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score =  105 bits (263), Expect = 2e-22
 Identities = 64/200 (32%), Positives = 113/200 (56%), Gaps = 10/200 (5%)

Query: 494 TVR--KQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAG 551
           TVR  K+  ++  P++VE C+ FI + GL+ EG+FR+ G    V ++++AF+ GE P + 
Sbjct: 140 TVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKP-SF 198

Query: 552 DQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERA--LHIRKVLLVLP 609
           D N  D+ ++A +LKLY R L  P+ P   + D ++C  + + +E A    + K +  LP
Sbjct: 199 DSNT-DVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLP 257

Query: 610 KTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQ---AHVNE 666
                +++Y+  FL+ +  +S  N M   NLA  FGP+++  P+  D ++       V +
Sbjct: 258 VVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQ 316

Query: 667 LIKTIIIQHENIFPSPRELE 686
           L+  +I +H+ +FP   EL+
Sbjct: 317 LMSVMISKHDCLFPKDAELQ 336


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  105 bits (262), Expect = 2e-22
 Identities = 60/190 (31%), Positives = 107/190 (56%), Gaps = 4/190 (2%)

Query: 501  SQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPL-AGDQNDHDMD 559
            +Q +PL+V +C R +   GL+  GI+RV G+   V+ ++    RG   +   D+   D++
Sbjct: 822  NQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLN 881

Query: 560  SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
             I+ +LK +FR L  PLF  D ++D +    +++ +ER   +RK++  LP      +++L
Sbjct: 882  VISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFL 941

Query: 620  FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGH--DQVSCQAHVNELIKTIIIQHEN 677
               L  ++  SE+N M+P NLA+ FGP+L+   E +  D V+      ++++T +IQH +
Sbjct: 942  VGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVET-LIQHSD 1000

Query: 678  IFPSPRELEG 687
             F S  E +G
Sbjct: 1001 WFFSDEEDKG 1010


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 63/180 (35%), Positives = 96/180 (53%), Gaps = 10/180 (5%)

Query: 505 PLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFER-GEDPLAGDQNDHDMDSIAG 563
           P+VV+ CIR I   GL  EG++RVSG    + D+K AF+R GE          D++ I G
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341

Query: 564 VLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFL 623
            LKLYFR L  PL   D +   +    + +  E+   + + L +LP      +RYL A L
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401

Query: 624 NHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNE-----LIKTIIIQHENI 678
             ++   +EN+M+  NL I FGP+LM  PE    +   A +N+     L+  ++I++E+I
Sbjct: 402 KRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALNDIRYQRLVVELLIKNEDI 457


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 63/180 (35%), Positives = 96/180 (53%), Gaps = 10/180 (5%)

Query: 505 PLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFER-GEDPLAGDQNDHDMDSIAG 563
           P+VV+ CIR I   GL  EG++RVSG    + D+K AF+R GE          D++ I G
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315

Query: 564 VLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFL 623
            LKLYFR L  PL   D +   +    + +  E+   + + L +LP      +RYL A L
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375

Query: 624 NHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNE-----LIKTIIIQHENI 678
             ++   +EN+M+  NL I FGP+LM  PE    +   A +N+     L+  ++I++E+I
Sbjct: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALNDIRYQRLVVELLIKNEDI 431


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 14/230 (6%)

Query: 453 KMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCI 512
           K++++L+ R  +  L+ K  +  +  G      C+LA      R +     +P  V+ CI
Sbjct: 302 KLRKFLQRRPTLQSLREKGYIKDQVFG------CALAALCERERSR-----VPRFVQQCI 350

Query: 513 RFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGL 572
           R +   GL  +G++R+SG+   +  ++   +  E     D    D+  I G LKL+FR L
Sbjct: 351 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFREL 410

Query: 573 EHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEE 632
             PLFP   F   +A + + +   R+  +R ++  LP      +R LF  L  + +  E+
Sbjct: 411 PEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQ 470

Query: 633 NMMDPYNLAICFGPSLMSVPEGHDQVSCQAHV--NELIKTIIIQHENIFP 680
           N M   ++AI FGP+L+  PE  +       V  N++++ I+ Q  +IFP
Sbjct: 471 NRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQQCADIFP 519


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 14/230 (6%)

Query: 453 KMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCI 512
           K++++L+ R  +  L+ K  +  +  G      C+LA      R +     +P  V+ CI
Sbjct: 329 KLRKFLQRRPTLQSLREKGYIKDQVFG------CALAALCERERSR-----VPRFVQQCI 377

Query: 513 RFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGL 572
           R +   GL  +G++R+SG+   +  ++   +  E     D    D+  I G LKL+FR L
Sbjct: 378 RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFREL 437

Query: 573 EHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEE 632
             PLFP   F   +A + + +   R+  +R ++  LP      +R LF  L  + +  E+
Sbjct: 438 PEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQ 497

Query: 633 NMMDPYNLAICFGPSLMSVPEGHDQVSCQAHV--NELIKTIIIQHENIFP 680
           N M   ++AI FGP+L+  PE  +       V  N++++ I+ Q  +IFP
Sbjct: 498 NRMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQQCADIFP 546


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 81/341 (23%), Positives = 159/341 (46%), Gaps = 29/341 (8%)

Query: 376  RLSTLKIE---NEEVKKTMEATLQTIQDI---------VTVEDFDVSDCFQYSNSMESVK 423
            RL+T   E     E +  M A ++TIQ+          VT  D       +Y+N M   +
Sbjct: 1010 RLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAE 1069

Query: 424  S---------TVSETFM---SKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKH 471
                      ++ +T +   S+P      + ++E+E+   +K  +    ++  T  +   
Sbjct: 1070 QLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSK-DDTSPPKDKGTWRKGIP 1128

Query: 472  DLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGS 531
             +++KT  +      +   R        +++ IPL+V+ C + +   GL++ GI+RV G+
Sbjct: 1129 SIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGN 1188

Query: 532  QVEVNDIKNAFERG-EDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVT 590
               ++ ++    +G  D    D    D++ I+ +LK +FR L  PLF  D + D +    
Sbjct: 1189 NAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANR 1248

Query: 591  MDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMS 650
             ++  +R   +++++  LP+     +++L A L  +++ SE+N M+P NLAI FGP+L+ 
Sbjct: 1249 KEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVR 1308

Query: 651  VPEGHDQVSCQAHVNELIKTI--IIQHENIFPSPRELEGPV 689
              E  +      H+ +  K +  +IQH + F +    E P+
Sbjct: 1309 TSE-DNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPL 1348


>gi|4505507 oligophrenin 1 [Homo sapiens]
          Length = 802

 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 129/596 (21%), Positives = 235/596 (39%), Gaps = 82/596 (13%)

Query: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
           SD YL++  P F     +  + +++  E   +   D++K  N L S M+ Y      S +
Sbjct: 9   SDCYLDS--PDF----RERLKCYEQELERTNKFIKDVIKDGNALISAMRNY------SSA 56

Query: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSV--------KKI 228
            Q   +  +  +   IG ++  ++     S    A +  E ++ R   V        K +
Sbjct: 57  VQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPL 116

Query: 229 EKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASL 288
           E  + K Q  +T+ + K  +   E   +L                       D   H S 
Sbjct: 117 ENFR-KEQIGFTKERKKKFEKDGERFYSL----------------------LDRHLHLSS 153

Query: 289 NRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPH 348
            +       A+L +++ +H   ++  + V  +    + ++      N+  P + F     
Sbjct: 154 KKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKF-----NIVEPVLAFLHSLF 208

Query: 349 MGDMASQLCAQQ--PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQT--IQDIVTV 404
           + +  +    Q   P + +L    Q  ++  S+ + E EE+KK M+   QT  +    T+
Sbjct: 209 ISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTI 268

Query: 405 EDFDVSD--------CFQYSNSMESVKSTVSETFMSKPSIAK------------RRANQQ 444
           E +  +           +Y    E    T++ T M +   AK            RR  + 
Sbjct: 269 EGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTES 328

Query: 445 ETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAI 504
             ++F F    E  E    IT LQA  +  ++   E+   D       S + KQ   +  
Sbjct: 329 IDKRFCFDI--ETNERPGTIT-LQALSEANRRLWMEAM--DGKEPIYHSPITKQQEMELN 383

Query: 505 PL---VVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD--QNDHDMD 559
            +    V  CI  I   G++ EG++R  GS ++V  + NAF   + P   D   +D D+ 
Sbjct: 384 EVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIK 443

Query: 560 SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
           +I   LK Y R L  P+    +  +L++    DNL  R   I  ++  LP+    ++  L
Sbjct: 444 TITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELL 503

Query: 620 FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQH 675
              L ++ + S+EN+M P N+ + FGP+LM   E             ++  I+I+H
Sbjct: 504 IRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEH 559


>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
           sapiens]
          Length = 645

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 70/263 (26%), Positives = 116/263 (44%), Gaps = 13/263 (4%)

Query: 463 LITKLQAKHDLLQKTLGESQRTDCSL--ARRSSTVRKQDS--SQAIPLVVESCIRFISRH 518
           L+   QA+ +   K L     T C +   R   TV  +       +P++VE C  FI  H
Sbjct: 131 LMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEH 190

Query: 519 GLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFP 578
           G   EGIFR+ G    V  +++AF+ GE P      D D+ ++A +LKLY R L  P+ P
Sbjct: 191 GRNEEGIFRLPGQDNLVKQLRDAFDAGERP--SFDRDTDVHTVASLLKLYLRDLPEPVVP 248

Query: 579 KDIFHDLMACVTMDNLQERAL--HIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMD 636
              +   + C  + N  E      + K L +LP+    ++ Y+  FL+ +      N M 
Sbjct: 249 WSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMS 308

Query: 637 PYNLAICFGPSLMSVPEGHDQVSCQA--HVNELIKTIIIQHENIFPSPRELEGPVYSRGG 694
             NLA   G +L+        V  +    +  ++  +I  HE +FP  +++     S   
Sbjct: 309 VDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP---LSPPA 365

Query: 695 SMEDYCDSPHGETTSVEDSTQDV 717
              D   +P   ++   D+T+D+
Sbjct: 366 QKNDPKKAPVARSSVGWDATEDL 388


>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
           sapiens]
          Length = 638

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 70/263 (26%), Positives = 116/263 (44%), Gaps = 13/263 (4%)

Query: 463 LITKLQAKHDLLQKTLGESQRTDCSL--ARRSSTVRKQDS--SQAIPLVVESCIRFISRH 518
           L+   QA+ +   K L     T C +   R   TV  +       +P++VE C  FI  H
Sbjct: 124 LMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEH 183

Query: 519 GLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFP 578
           G   EGIFR+ G    V  +++AF+ GE P      D D+ ++A +LKLY R L  P+ P
Sbjct: 184 GRNEEGIFRLPGQDNLVKQLRDAFDAGERP--SFDRDTDVHTVASLLKLYLRDLPEPVVP 241

Query: 579 KDIFHDLMACVTMDNLQERAL--HIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMD 636
              +   + C  + N  E      + K L +LP+    ++ Y+  FL+ +      N M 
Sbjct: 242 WSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMS 301

Query: 637 PYNLAICFGPSLMSVPEGHDQVSCQA--HVNELIKTIIIQHENIFPSPRELEGPVYSRGG 694
             NLA   G +L+        V  +    +  ++  +I  HE +FP  +++     S   
Sbjct: 302 VDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIP---LSPPA 358

Query: 695 SMEDYCDSPHGETTSVEDSTQDV 717
              D   +P   ++   D+T+D+
Sbjct: 359 QKNDPKKAPVARSSVGWDATEDL 381


>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
            sapiens]
          Length = 1499

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 47/146 (32%), Positives = 88/146 (60%), Gaps = 1/146 (0%)

Query: 504  IPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAG 563
            IP+ +E CI +I   GL  EGI+RVSG++ E+  ++  F++  + L   + D  ++++AG
Sbjct: 1261 IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHN-LDLAEKDFTVNTVAG 1319

Query: 564  VLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFL 623
             +K +F  L  PL P ++  DL+    +++ +++   +++VL   PK    + +Y+ + L
Sbjct: 1320 AMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHL 1379

Query: 624  NHLSQFSEENMMDPYNLAICFGPSLM 649
            N +S  ++ N+M   NL+ICF P+LM
Sbjct: 1380 NKVSHNNKVNLMTSENLSICFWPTLM 1405


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 49/161 (30%), Positives = 88/161 (54%), Gaps = 1/161 (0%)

Query: 493  STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
            + V K++ S+ +P +V  C+  I R G++  GI+RVSG   ++  +K AF+     ++  
Sbjct: 1013 AVVTKRERSK-VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVM 1071

Query: 553  QNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTT 612
             ++ D+++IAG LKLYFR L  PLF  + + +    + + +   +   +  +LL LP+  
Sbjct: 1072 MSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEAN 1131

Query: 613  LIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPE 653
            L+   +L   L  +++    N M  +NLA  FGP+L+   E
Sbjct: 1132 LLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1172


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 49/161 (30%), Positives = 88/161 (54%), Gaps = 1/161 (0%)

Query: 493  STVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD 552
            + V K++ S+ +P +V  C+  I R G++  GI+RVSG   ++  +K AF+     ++  
Sbjct: 1057 AVVTKRERSK-VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVM 1115

Query: 553  QNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTT 612
             ++ D+++IAG LKLYFR L  PLF  + + +    + + +   +   +  +LL LP+  
Sbjct: 1116 MSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEAN 1175

Query: 613  LIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPE 653
            L+   +L   L  +++    N M  +NLA  FGP+L+   E
Sbjct: 1176 LLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 57/227 (25%), Positives = 110/227 (48%), Gaps = 13/227 (5%)

Query: 454 MKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIR 513
           +K++L  R  +  ++ K  +  +  G +    C           Q  +  +P  V+ CI 
Sbjct: 630 LKKFLTRRPTLQAVREKGYIKDQVFGSNLANLC-----------QRENGTVPKFVKLCIE 678

Query: 514 FISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLE 573
            +  HGL  +GI+RVSG+   +  ++ A    E     D    D+  I G LK++FR L 
Sbjct: 679 HVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELP 738

Query: 574 HPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEEN 633
            PLF  + F+D +  +  +  ++R   ++ ++  LPK     M+ LF  L  + +  E+N
Sbjct: 739 EPLFTFNHFNDFVNAIKQEP-RQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKN 797

Query: 634 MMDPYNLAICFGPSLMSVPEGHDQVSCQ-AHVNELIKTIIIQHENIF 679
            M   ++AI FGP+L+   +    ++    + N++++ I+++  +IF
Sbjct: 798 RMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIF 844



 Score = 30.8 bits (68), Expect = 7.1
 Identities = 15/54 (27%), Positives = 29/54 (53%), Gaps = 3/54 (5%)

Query: 731 IEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGR--HNGIDGLIPHQYI 782
           IE    ++Y  +  R++  K+G   +L ++ +DDWW+ +   N     +P QY+
Sbjct: 17  IEVEYDYEYEAKD-RKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYV 69


>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
          Length = 740

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 92/344 (26%), Positives = 148/344 (43%), Gaps = 52/344 (15%)

Query: 22  KEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRST 81
           +E++    EQM  L  + +    LL+D++ F +KKA IE +Y++ ++KLA ++L +    
Sbjct: 12  QELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPG 71

Query: 82  KDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKK 141
                + D   + PV  W   L    + ++    + + Y N I         +  R  + 
Sbjct: 72  VKADDRNDYRSMYPV--WKSFLEGTMQVAQSRMNICENYKNFI--------SEPARTVRS 121

Query: 142 SKEVGQQLQ---DDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQ 198
            KE  QQL+   D L K+  EL   +K       D    + K  E E     Q+  +V++
Sbjct: 122 LKE--QQLKRCVDQLTKIQTELQETVK-------DLAKGKKKYFETE-----QMAHAVRE 167

Query: 199 EDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALE 258
           +           A++  + K     S   ++K   K +A+ +E   KA  ARN+YLL L 
Sbjct: 168 K-----------ADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLA 216

Query: 259 ATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVE 318
           A NA   +YY  DL +++ +  D   +  L   L  F   EL       E   A++N  +
Sbjct: 217 AANAHQDRYYQTDLVNIM-KALDGNVYDHLKDYLIAFSRTEL-------ETCQAVQNTFQ 268

Query: 319 NLDATSDK------QRLMEMYNNVFCPPMKFEFQPHMGDMASQL 356
            L   S K       +L    N VF  P  F+FQP   D + QL
Sbjct: 269 FLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQL 312



 Score = 38.5 bits (88), Expect = 0.034
 Identities = 19/47 (40%), Positives = 28/47 (59%), Gaps = 3/47 (6%)

Query: 735 AKFDYVGRTARELSFKKGASLLLYQRASDD---WWEGRHNGIDGLIP 778
           A +DY G+T  ELSF +GA + +  + + D   +WEG  NG  G+ P
Sbjct: 574 ALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFP 620


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 57/234 (24%), Positives = 106/234 (45%), Gaps = 12/234 (5%)

Query: 452 TKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESC 511
           +++K+++  R  +  LQ K  +  +  G      C   R +STV         P  V+ C
Sbjct: 253 SRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCE--RENSTV---------PWFVKQC 301

Query: 512 IRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRG 571
           I  + + GL  +GI+RVSG+   +  ++    + E     D    D+  + G LK++FR 
Sbjct: 302 IEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRE 361

Query: 572 LEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSE 631
           L  PLFP   F   +  +   +   R   ++ ++  LP      M+ LF  L  +   + 
Sbjct: 362 LPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKAS 421

Query: 632 ENMMDPYNLAICFGPSLMSVP-EGHDQVSCQAHVNELIKTIIIQHENIFPSPRE 684
           +N+M   +L I FGP+L+    E  +      + N++ + ++ ++  IF S  +
Sbjct: 422 KNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED 475


>gi|89886350 Rho GTPase activating protein 11B [Homo sapiens]
          Length = 267

 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 54/165 (32%), Positives = 89/165 (53%), Gaps = 7/165 (4%)

Query: 507 VVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLK 566
           +V++C   +  H +  EG+FR SGS + +  +KN  + GE    G  +      IAG+LK
Sbjct: 69  LVDACTS-LEEH-IHTEGLFRKSGSVIRLKALKNKVDHGE----GCLSSAPPCDIAGLLK 122

Query: 567 LYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHL 626
            +FR L  P+ P D+ H+ +        +E+   I  +  +L   T+ ++RY F FL ++
Sbjct: 123 QFFRELPEPILPADL-HEALLKAQQLGTEEKNKAILLLSCLLADHTVHVLRYFFNFLRNV 181

Query: 627 SQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTI 671
           S  S EN MD  NLA+ F P+L+   EGH+++S  A    + +T+
Sbjct: 182 SLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAEKKGVYQTL 226


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 9/190 (4%)

Query: 498 QDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHD 557
           Q+  + I L +E+C+  +   G++ EG+FR++     +  +K       DP + ++   D
Sbjct: 283 QELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTM--ASDPHSLEEFCSD 340

Query: 558 MDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMR 617
             ++AG LK Y R L  PL   D++ D M   ++     R   +++V   LP   L  +R
Sbjct: 341 PHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLR 400

Query: 618 YLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGH-DQVSCQA------HVNELIKT 670
           YL  FL  L++  E N M P N+AI  GP+L+  PE   DQ    A       V  +++ 
Sbjct: 401 YLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEA 460

Query: 671 IIIQHENIFP 680
           +I   + +FP
Sbjct: 461 LIQSADTLFP 470


>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
          Length = 1502

 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 52/181 (28%), Positives = 96/181 (53%), Gaps = 2/181 (1%)

Query: 500  SSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMD 559
            + + IPL VE C+ FI   GL  EG++RVSG++ + ++I+  F++  + +     +  ++
Sbjct: 1270 AEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHN-INLVSMEVTVN 1328

Query: 560  SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
            ++AG LK +F  L  PL P  +  +L+    + +  ER   +++++         + RY+
Sbjct: 1329 AVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYV 1388

Query: 620  FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVP-EGHDQVSCQAHVNELIKTIIIQHENI 678
               LN +SQ  + N+M   NL+ICF P+LM    E  + +S       +++T I Q +  
Sbjct: 1389 ITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFF 1448

Query: 679  F 679
            F
Sbjct: 1449 F 1449


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,085,965
Number of Sequences: 37866
Number of extensions: 1791457
Number of successful extensions: 9079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 251
Number of HSP's successfully gapped in prelim test: 428
Number of HSP's that attempted gapping in prelim test: 7563
Number of HSP's gapped (non-prelim): 1691
length of query: 1071
length of database: 18,247,518
effective HSP length: 113
effective length of query: 958
effective length of database: 13,968,660
effective search space: 13381976280
effective search space used: 13381976280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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