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Search of human proteins with 111955162
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
(1044 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 2023 0.0
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 2005 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 130 5e-30
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 130 5e-30
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 130 5e-30
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 130 5e-30
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 130 5e-30
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 130 5e-30
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 130 5e-30
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 130 5e-30
gi|148746195 trichohyalin [Homo sapiens] 126 9e-29
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 115 2e-25
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 113 1e-24
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 111 4e-24
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 110 7e-24
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 110 7e-24
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 110 7e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 110 7e-24
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 110 7e-24
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 110 7e-24
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 110 7e-24
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 108 2e-23
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 103 1e-21
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 102 1e-21
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 102 1e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 102 2e-21
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 101 3e-21
gi|16262452 cingulin [Homo sapiens] 100 7e-21
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 100 1e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 99 2e-20
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 2023 bits (5242), Expect = 0.0
Identities = 1044/1044 (100%), Positives = 1044/1044 (100%)
Query: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE
Sbjct: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
Query: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS
Sbjct: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
Query: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN
Sbjct: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
Query: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA
Sbjct: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
Query: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK
Sbjct: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
Query: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG
Sbjct: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
Query: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP
Sbjct: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH
Sbjct: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
Query: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG
Sbjct: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
Query: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR
Sbjct: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
Query: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT
Sbjct: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
Query: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK
Sbjct: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
Query: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELE 780
QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELE
Sbjct: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELE 780
Query: 781 ELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEA 840
ELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEA
Sbjct: 781 ELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEA 840
Query: 841 WLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSE 900
WLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSE
Sbjct: 841 WLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSE 900
Query: 901 LEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQV 960
LEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQV
Sbjct: 901 LEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQV 960
Query: 961 IRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
IRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE
Sbjct: 961 IRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
Query: 1021 AAVKRADHLEELLEQHRRPTPSTK 1044
AAVKRADHLEELLEQHRRPTPSTK
Sbjct: 1021 AAVKRADHLEELLEQHRRPTPSTK 1044
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 2005 bits (5195), Expect = 0.0
Identities = 1044/1080 (96%), Positives = 1044/1080 (96%), Gaps = 36/1080 (3%)
Query: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE
Sbjct: 1 MKGTRAIGSVPERSPAGVDLSLTGLPPPVSRRPGSAATTKPIVRSVSVVTGSEQKRKVLE 60
Query: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS
Sbjct: 61 ATGPGGSQAINNLRRSNSTTQVSQPRSGSPRPTEPTDFLMLFEGSPSGKKRPASLSTAPS 120
Query: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN
Sbjct: 121 EKGATWNVLDDQPRGFTLPSNARSSSALDSPAGPRRKECTVALAPNFTANNRSNKGAVGN 180
Query: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA
Sbjct: 181 CVTTMVHNRYTPSERAPPLKSSNQTAPSLNNIIKAATCEGSESSGFGKLPKNVSSATHSA 240
Query: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK
Sbjct: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
Query: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG
Sbjct: 301 REEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
Query: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP
Sbjct: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH
Sbjct: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTH 480
Query: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG
Sbjct: 481 HRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSG 540
Query: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR
Sbjct: 541 QDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR 600
Query: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT
Sbjct: 601 RVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
Query: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK
Sbjct: 661 ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
Query: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ------- 773
QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ
Sbjct: 721 QEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLE 780
Query: 774 -----------------------------RQRAELEELRQQLEESSSALTRALRAEFEKG 804
RQRAELEELRQQLEESSSALTRALRAEFEKG
Sbjct: 781 QEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALTRALRAEFEKG 840
Query: 805 REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 864
REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV
Sbjct: 841 REEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELV 900
Query: 865 IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG 924
IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG
Sbjct: 901 IHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEG 960
Query: 925 ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 984
ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA
Sbjct: 961 ENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 1020
Query: 985 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1044
TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK
Sbjct: 1021 TLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1080
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1479 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1581
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1638
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1875
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 1996 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1951
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2012 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2069
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2070 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2125
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2299
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2360 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2411 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2457 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2505
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2559
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRR 2581
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1824 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1881
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2062 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2352
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1384 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1441 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1615
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1616 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1659
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1696
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1697 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2162
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2163 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2200
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2257
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2258 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2372
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2373 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2427
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2485
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2486 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2539
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2659
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2660 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2715
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2716 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2766
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 951 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 1006
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 1007 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1055
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1056 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1099
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1150
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1151 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1259
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1319
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1320 RTHYSEL 1326
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 446
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 447 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 502
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 503 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 558
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 615
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 616 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 668 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 717
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 718 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 777
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 778 KGHLSGLAKR 787
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1483 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1585
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1642
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1823 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1879
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 2000 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2058
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1955
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2016 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2073
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2074 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2129
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2303
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2364 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2415 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2461 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2509
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2563
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRR 2585
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1767
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1768 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1827
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1828 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1885
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1945
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1946 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2066 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2241 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2356
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1328 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1388 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1444
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1445 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1502
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1562
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1619
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1620 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1663
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1700
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1701 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1993 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2051
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2166
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2167 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2204
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2261
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2262 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2319
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2376
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2377 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2431
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2489
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2490 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2543
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2604 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2663
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2664 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2719
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2720 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2770
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 955 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 1010
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 1011 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1059
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1060 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1103
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1104 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1154
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1155 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1263
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1264 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1323
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1324 RTHYSEL 1330
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 402 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 450
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 451 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 506
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 507 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 562
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 563 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 619
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 620 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 671
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 672 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 721
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 722 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 781
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 782 KGHLSGLAKR 791
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1479 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1581
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1638
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1875
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 1996 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1951
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2012 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2069
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2070 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2125
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2299
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2360 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2411 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2457 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2505
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2559
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRR 2581
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1824 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1881
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1941
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1942 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2062 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2237 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2352
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1384 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1441 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1615
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1616 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1659
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1696
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1697 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2162
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2163 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2200
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2257
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2258 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2372
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2373 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2427
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2485
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2486 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2539
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2600 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2659
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2660 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2715
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2716 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2766
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 951 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 1006
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 1007 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1055
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1056 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1099
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1150
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1151 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1259
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1319
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1320 RTHYSEL 1326
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 446
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 447 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 502
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 503 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 558
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 615
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 616 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 668 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 717
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 718 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 777
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 778 KGHLSGLAKR 787
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1327 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1447 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1493 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1549
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1606
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1787 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1843
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 1964 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2022
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1919
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 1980 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2037
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2038 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2093
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2267
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2328 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2378
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2379 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2425 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2473
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2527
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRR 2549
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1731
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1732 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1791
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1792 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1849
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1909
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1910 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2030 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2205 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2320
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1292 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1352 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1408
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1409 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1466
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1526
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1583
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1584 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1627
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1664
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1665 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1957 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2015
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2130
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2131 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2168
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2225
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2226 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2340
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2341 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2395
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2453
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2454 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2507
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2568 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2627
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2628 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2683
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2684 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2734
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 919 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 974
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 975 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1023
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1024 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1067
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1068 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1118
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1119 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1227
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1228 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1287
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1288 RTHYSEL 1294
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 366 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 414
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 415 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 470
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 471 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 526
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 527 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 583
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 584 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 635
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 636 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 685
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 686 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 745
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 746 KGHLSGLAKR 755
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1616 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1718
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1775
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 2012
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 2133 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2191
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 2088
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2149 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2206
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2207 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2262
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2436
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2497 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2547
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2548 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2594 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2642
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2696
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRR 2718
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1900
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1901 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1960
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1961 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 2018
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 2078
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 2079 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2199 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2374 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2489
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1521 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1577
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1578 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1635
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1695
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1696 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1752
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1753 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1796
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1833
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1834 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 2126 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2184
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2299
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2300 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2337
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2394
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2395 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2452
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2509
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2510 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2564
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2622
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2623 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2676
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2737 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2796
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2797 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2852
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2853 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2903
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 1088 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 1143
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 1144 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1192
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1193 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1236
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1237 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1287
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1288 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1396
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1397 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1456
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1457 RTHYSEL 1463
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 535 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 583
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 584 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 639
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 640 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 695
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 696 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 752
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 753 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 805 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 854
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 855 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 914
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 915 KGHLSGLAKR 924
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1457 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1503 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1559
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1616
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1853
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 1974 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2032
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1929
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 1990 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2047
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2048 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2103
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2277
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2338 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2388
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2389 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2435 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2483
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2537
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRR 2559
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1741
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1742 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1801
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1802 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1859
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1919
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1920 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2040 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2215 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2330
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1302 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1362 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1418
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1419 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1476
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1536
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1537 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1593
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1594 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1637
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1674
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1675 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1967 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2025
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2140
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2141 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2178
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2235
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2236 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2293
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2350
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2351 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2405
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2463
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2464 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2517
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2578 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2637
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2638 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2693
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2694 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2744
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 929 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 984
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 985 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1033
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1034 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1077
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1078 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1128
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1129 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1237
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1238 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1297
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1298 RTHYSEL 1304
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 376 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 424
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 425 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 480
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 481 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 536
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 537 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 593
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 594 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 645
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 646 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 695
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 696 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 755
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 756 KGHLSGLAKR 765
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1345 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1465 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1511 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1567
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1624
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1861
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 1982 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2040
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1937
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 1998 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2055
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2056 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2111
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2285
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2346 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2396
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2397 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2443 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2491
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2545
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRR 2567
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1749
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1750 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1809
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1810 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1867
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1927
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1928 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2048 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2223 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2283 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2338
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1370 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1426
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1427 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1484
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1544
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1545 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1601
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1602 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1645
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1682
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1683 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 1975 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2033
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2148
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2149 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2186
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2243
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2244 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2301
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2358
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2359 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2413
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2471
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2472 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2525
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2585
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2586 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2645
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2646 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2701
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2702 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2752
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 937 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 992
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 993 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1041
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1042 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1085
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1086 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1136
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1137 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1245
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1246 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1305
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1306 RTHYSEL 1312
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 384 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 432
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 433 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 488
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 489 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 544
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 545 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 601
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 602 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 653
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 654 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 703
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 704 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 763
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 764 KGHLSGLAKR 773
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 130 bits (328), Expect = 5e-30
Identities = 203/873 (23%), Positives = 350/873 (40%), Gaps = 141/873 (16%)
Query: 280 RHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA 339
R ++ A + L +A + + Q E L Q+E RR+ A+Q +R+
Sbjct: 1386 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445
Query: 340 IQELQQKR-------ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQAL 392
+ELQQ R +A++A AER E RV ++ A E QAL
Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Query: 393 KANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK 452
+A R + Q+ E + V + E+ SR A+
Sbjct: 1506 RA--------------RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551
Query: 453 SRGPLE-----ELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGK 507
+ E + L L+L +E + R R R + E S A E K
Sbjct: 1552 AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA---ELQSK 1608
Query: 508 LSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVS 567
++F E + + ++ +E E+ Q Q ++++ E LE +
Sbjct: 1609 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER---AREEAERELERWQLKA 1665
Query: 568 TSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA----------LSRQLQRQR 617
+RL+L+ EE Q L Q +Q++ R + KA ++L++QR
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 618 EHYEATIQRHLAFIDQLI------EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+ E T Q+ LA +LI E + + E +A L++E T++ + +A+
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 672 LEIKKLKELMSATEKARRE-KWISEKTKKIKEVTV---RGLEPEIQKL------------ 715
+++ L+++ +A E + SEK+K+ E R L E +L
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845
Query: 716 -----IARHKQEVRR-----LKSLHEAELLQSDERASQRCLRQAEELREQLER--EKEAL 763
AR + E R L ++ EA L+++ ++ L++ E E+L R E EA
Sbjct: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTE---AEIALKEKEAENERLRRLAEDEAF 1902
Query: 764 GQQERERARQRQRAELEELRQQLEESS-SALTR--------------------ALRAEFE 802
++ E + +A++EE QL ++S S L R AL+A FE
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 803 K---GREEQE------RRHQMELNTLKQQLELE-----RQAWEAGRTRKEEAWLLNREQE 848
K G+ E E R + + K+Q ELE + A E R R+E + +
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEK-----------AAESRIKRLRDKYEAE 897
EE + R +E + RL+A + A+ E+ A E+ KRL+ + +A
Sbjct: 2023 AEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081
Query: 898 LSELEQSERKLQERCSELKGQL----GEA--------EGENLRLQG--LVRQKERALEDA 943
++Q E++LQ+ + + L GEA E E R+Q Q R +E+A
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2141
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE-EVHRRVK 1002
+ + + + AQ + R A +E R+A+AE A L+ +Q + E E H++
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
R++ V T ++ DH + LL++
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Score = 124 bits (312), Expect = 4e-28
Identities = 212/862 (24%), Positives = 357/862 (41%), Gaps = 139/862 (16%)
Query: 252 RRKEVTEEEAERFIHQVNQATV--TIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
+ K+ E EA RF +A + + Q Q AAR + E+ G
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
Query: 310 EGTLLDLH-----QQKEAARRKAR---EEKARQARRAAIQELQQK-----RALRAQKAST 356
E T L ++KEA + R E++A Q RR Q Q K R + +KAS
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930
Query: 357 AERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDS 416
+E + E + RQ +E+ ALKA+ AAG + L
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEIL---------ALKASFEKA---AAGKAELELELGRI 1978
Query: 417 SPEPQQPPEDRTQDVLA-----QDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEP 471
+ + Q L Q AA + KS EE + +E
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 472 DVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMS 531
+ L + + R +E++ A L +L A + E +LQ +
Sbjct: 2039 ERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL- 2096
Query: 532 FLDEMEKSGQDQLDSQQEGW---VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ 588
+ E+S DQL + E EA ++ E + S +++ E E KQ+
Sbjct: 2097 ---QQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2152
Query: 589 RALAQQRDLTARRVKETEKALSRQLQ------RQREHYEATIQRHLAFIDQLIEDKKVLS 642
+A AQ + + KE E+ +R+ Q RQ++ +A +++H F +Q + K +
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 643 EKCEAVVAELKQEDQR--------------CTERVAQ-AQAQHEL--------EIKKLKE 679
++ + +L++ D + TE Q +Q + EL E+ KLK
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 680 LMSATEKA-------RREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
+ A +A ++++ E+ +K+K+V + QE RL+ L E
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA------QEAARLRQLAEE 2326
Query: 733 ELLQSDERASQRCLRQAEELREQLEREKEA-LGQQERERARQRQRA---ELEELRQQLEE 788
+L Q A + + + ++E + EA L QQ++E A+++ R + E++ QQL E
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+ R L AE R+ Q+E++ ++L+L + R EE R+Q
Sbjct: 2387 ETQGFQRTLEAE---------RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA 2437
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES-RIKRLRDKYEAE-----LSELE 902
+EI +HR E LA +E ++ I+R + ++AE ++ELE
Sbjct: 2438 ----------EEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 903 QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+ + KLQ+ L QL E + + Q+E+ L++ QA+ + SE+ +L Q R
Sbjct: 2484 REKEKLQQEAKLL--QLKSEEMQTV-------QQEQLLQETQALQQSFLSEKDSLLQ--R 2532
Query: 963 QEFEDRLAASEEETRQ---AKAE-LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
+ F ++ A E+ Q AKA+ L Q RQQ ++E+ +R+ +A EEA R Q
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL---VASMEEA---RRRQ 2586
Query: 1019 HEA--AVKRADHLEELLEQHRR 1038
HEA V+R + LEQ RR
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRR 2608
Score = 120 bits (301), Expect = 7e-27
Identities = 206/897 (22%), Positives = 365/897 (40%), Gaps = 119/897 (13%)
Query: 245 GGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQ 304
GG+ G + EEAE Q + ++R + + QR+ L ++A+ E
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 305 RQRSGE-GTLLDLHQQKEAARRKARE---EKARQ-------ARRAAIQELQQKRALRAQK 353
R++ L +L Q E A R+ R+ E+ARQ A+R+A ELQ KRA A+K
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 354 ASTAERGPPE---------NPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAA 404
+ ER E E R + + LKAN A
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 405 GPGDRCLPTSDSSPEPQQPPEDR---------TQDVLAQDAAGDNLEMMAP-SRGSAKSR 454
+ + + E Q+ +R Q V ++ A LE + G+A+ R
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 455 GPLEELLHTL-----------QLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLE 503
E+ L L QLLE+E R A ++ + L E
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEE-----LARLQREAAAATQKRQELEAELAKVRAE 1790
Query: 504 KFGKLSAFPEPPEDGTLLSEAKLQSIMS----FLDEMEKSGQ-----DQLDSQQEGWVPE 554
L++ E+ SE Q + + F + E++ + ++ Q++ +
Sbjct: 1791 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1850
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
A E ++ + + K +A + L+ A+ L RR+ E E R+L+
Sbjct: 1851 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLE 1908
Query: 615 RQREHYEATIQRHLAFI----DQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQ 667
Q ++A I+ LA + D +E +K L E ++++E + E+ A +
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGK 1968
Query: 668 AQHELEIKKLK----ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
A+ ELE+ +++ + + + E+A E + +E R E +QK +A ++
Sbjct: 1969 AELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 724 RRLK-SLHEAELLQSDERASQRCLRQAE-ELREQLEREKEA----LGQQERERARQRQRA 777
R+ K +L E E L++ ++R +AE E QL+ +EA L +E+ A Q+
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR- 836
E +EL+Q L++ S L + LR E E R E + + ++ + RQ EA R +
Sbjct: 2089 E-QELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2146
Query: 837 --KEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKE------ESEKAAESRIK 888
+E+A + Q E++RK ++E R +A+ A ++ E EK + +
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQE---AARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 889 RLRDKYEAE---------LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
LR K + E L E + + L E LK + EA + +++ +
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 940 LEDAQAVNEQLSSE--------RSNLAQVIRQEFEDRLAASEEETR-------------Q 978
+E+ + ++ +E + N + +++E E +EE R
Sbjct: 2264 MEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323
Query: 979 AKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
A+ +LA +A + L+E + V+ A K EA L+ Q E A ++A L+E EQ
Sbjct: 2324 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQ 2379
Score = 109 bits (273), Expect = 1e-23
Identities = 150/530 (28%), Positives = 221/530 (41%), Gaps = 103/530 (19%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
SE++T + + E + M +R QQR R+ E E AL +Q Q H +A
Sbjct: 1351 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 624 IQ--RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELM 681
Q R + Q ++++ V E EA V + +Q+ + E + Q + E EI+
Sbjct: 1411 AQAEREAKELQQRMQEEVVRRE--EAAV-DAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1467
Query: 682 SATEKARREKWISEKTKKIK---EVTVR---GLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
A E++R I E+ + ++ E T R G E E+Q L AR ++ E ++ ++ EAE
Sbjct: 1468 EAAERSRLR--IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1525
Query: 735 LQ---SDE----------------------RASQRCLRQAEELREQLEREKEALGQQERE 769
L+ DE R QR L+ EELR Q E + L Q E E
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1585
Query: 770 RARQRQ----------RAELEELRQQLEESSSALTRALRAEF---EKGREEQERRHQMEL 816
RARQ Q AEL+ R E ++ L R+L+ E + REE ERR Q
Sbjct: 1586 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--- 1642
Query: 817 NTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAK 876
QQ E ER EA R+ E W L + LR + L + +LA+
Sbjct: 1643 ----QQAEAERAREEA--ERELERWQLKANEALR----------LRLQAEEVAQQKSLAQ 1686
Query: 877 EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
E+EK E + R + +AE + Q E L E E E K
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRE-------------LAEQELE----------K 1723
Query: 937 ERALEDAQAVNEQLSSERS--NLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLEL 994
+R L + A ++L++E+ L Q + R EE R + A Q RQ+LE
Sbjct: 1724 QRQLAEGTA-QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782
Query: 995 E--EVHRRVKTALARKEEAVSSLRTQHEAAVKR----ADHLEELLEQHRR 1038
E +V ++ LA K A R+ E + +R A EL E+ R
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832
Score = 103 bits (256), Expect = 1e-21
Identities = 179/831 (21%), Positives = 348/831 (41%), Gaps = 91/831 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG 287
++ K++++ +AR + R K EE A R + Q + + + Q+R
Sbjct: 2016 RVQKSLAAEEEAARQRKAALEEVERLKAKVEE-ARRLRERAEQESARQLQLAQEAAQKRL 2074
Query: 288 AGAARLEHLLQAKREEQRQRS--GEGTLLD-LHQQKEAARRKARE-EKAR-QARRAAIQE 342
+ ++E++ Q++ E ++LD L + EAARR A E E+AR QA R A Q
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
Query: 343 LQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLP 402
+Q K S E+ + +R+ A++ + AL+
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA----- 2189
Query: 403 AAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLH 462
+D+ E + ++T AQ + R LEE H
Sbjct: 2190 -----------ADAEMEKHKKFAEQTLRQKAQ-----------VEQELTTLRLQLEETDH 2227
Query: 463 TLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLS 522
LL++E L T + + EE + + +E+ KL A E +L
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV---QMEELSKLKARIEAENRALILR 2284
Query: 523 EAKLQSIMSFLDE--------MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK 574
+ + FL E E++ + + +Q+ + + L ++ +++ K
Sbjct: 2285 DK--DNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2342
Query: 575 LEVEEKKQAMLLLQRALAQQRDLT---ARRVKETEKALSRQLQRQREHYEATIQRHLAFI 631
++ ++ + L QQ++L ARR++E ++ +++QL + + ++ T++
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--- 2399
Query: 632 DQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK 691
Q + +E+ + VAE+ + R E + + Q E ++ E + TE A +EK
Sbjct: 2400 -QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEK 2454
Query: 692 WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ--SDERAS---QRCL 746
+T +I+ +++ IA ++E +L+ EA+LLQ S+E + ++ L
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLL 2512
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ + L++ EK++L Q RER ++++A+LE+L Q A + LR E ++ ++
Sbjct: 2513 QETQALQQSFLSEKDSLLQ--RERFIEQEKAKLEQLFQD----EVAKAQQLREEQQRQQQ 2566
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ E+ Q + ++++ + +A E R ++EE L +++ +EE+ ++ + +
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2626
Query: 867 RLEAD--MALAKEE----SEKAAESRIKRLRDKYEAELSELEQS------ERKLQERCSE 914
LE ALA E S+ AA + RD + +E E RK+ + +
Sbjct: 2627 LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQ 2686
Query: 915 LKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE 974
G L E + L QG E L + V L RS++A ++ + ++L+
Sbjct: 2687 EAGILSAEELQRL-AQGHTTVDE--LARREDVRHYLQG-RSSIAGLLLKATNEKLSVYAA 2742
Query: 975 ETRQAKAE-----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
RQ + L QA L+ V R T +E V H+
Sbjct: 2743 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHK 2793
Score = 53.9 bits (128), Expect = 8e-07
Identities = 103/427 (24%), Positives = 174/427 (40%), Gaps = 57/427 (13%)
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+L +RE+ + H + Q +E +C+ ++ELK D R + + H
Sbjct: 978 RLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQRCISELK--DIRLQLEACETRTVHR 1033
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHE 731
L + KE A E A+R I+E+ K EV G K +AR E ++ +L E
Sbjct: 1034 LRLPLDKE--PARECAQR---IAEQQKAQAEVEGLG------KGVARLSAEAEKVLALPE 1082
Query: 732 AELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSS 791
A LR +LE LG+ E+ R+ E + + +
Sbjct: 1083 PS-------------PAAPTLRSELEL---TLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1126
Query: 792 ALTRALRAEFEKGREEQERRHQM-ELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR 850
LRA E+ +E Q + EL K L+ R EA + + LR
Sbjct: 1127 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA---------LR 1177
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+E+R ++ L E D+ E E+ E R+ +L ++++A L++ + +R+L++
Sbjct: 1178 DELRGAQEVGERLQQRHGERDV-----EVERWRE-RVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERA----LEDAQAVNEQLSSERSNLAQVIRQEFE 966
+L+ A+ LQ R++E+ L D+QAV EQL E Q + +E E
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE-----QALLEEIE 1286
Query: 967 DRLAASEEETRQAKAELATLQARQ-QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKR 1025
EE R AK + ++ + QL + + A+K + S + + V
Sbjct: 1287 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1346
Query: 1026 ADHLEEL 1032
H EL
Sbjct: 1347 RTHYSEL 1353
Score = 39.3 bits (90), Expect = 0.020
Identities = 104/430 (24%), Positives = 174/430 (40%), Gaps = 76/430 (17%)
Query: 570 VMRLKLEV----EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
V +L++E E+ QA LLQ + R L A +V + + R L +
Sbjct: 425 VTKLQMEAGLCEEQLNQADALLQ---SDVRLLAAGKVPQRAGEVERDLDKAD-------- 473
Query: 626 RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATE 685
+ I L D + L + ++ + R ER+ + ++ L +K AT+
Sbjct: 474 ---SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA-GVAAPATQ 529
Query: 686 KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER--ASQ 743
A+ ++ ++++ T+R L Q L+A ++ R+ L S E S
Sbjct: 530 VAQVTLQSVQRRPELEDSTLRYL----QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 585
Query: 744 RCLRQA-EELREQLEREKEALGQ-QERERARQRQ-RAELEELRQQLEESSSALTRALRAE 800
R L Q+ EE R ++ER + GQ R R L+ +L SS A R+L
Sbjct: 586 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL--- 642
Query: 801 FEKGREEQERRHQMELNTLKQQLEL-ERQAWEAG----------RTRKEEAWLLNREQEL 849
E H K+ + L E++ E G +KE L RE EL
Sbjct: 643 --------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 694
Query: 850 REEIRKGRDKEIELVIHRL--EADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
+E+ + KE++ RL E A ES +AA L+ ++ L E
Sbjct: 695 KEK----KIKELQNAGDRLLREDHPARPTVESFQAA------LQTQWSWMLQLCCCIEAH 744
Query: 908 LQERCSELK--GQLGEAEGENLRLQGLVRQK------------ERALEDAQAVNEQLSSE 953
L+E + + + EAEG+ +LQ +R+K E L+DAQ EQL+
Sbjct: 745 LKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 804
Query: 954 RSNLAQVIRQ 963
+ +L+ + ++
Sbjct: 805 KGHLSGLAKR 814
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 126 bits (317), Expect = 9e-29
Identities = 192/785 (24%), Positives = 320/785 (40%), Gaps = 88/785 (11%)
Query: 294 EHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQE-----LQQKRA 348
E LLQ +R+E+ QR E L ++ RR+ R+E+ R+ Q L+Q+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166
Query: 349 LRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGD 408
R + +R + E R + + + T + L+
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL----------- 215
Query: 409 RCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLE 468
L E +Q QD + Q+ + + EE +L E
Sbjct: 216 --LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 469 KEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQS 528
+E + R R EE L + + + E E+ E +
Sbjct: 274 EEEQLRKLERQELRRERQ--EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR--- 328
Query: 529 IMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEE-KKQAMLLL 587
++ E+ + QL +QE E L E +L+ E EE +++ L
Sbjct: 329 -----EQQEERREQQLRREQE----ERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHY---EATIQRHLAFIDQLIEDKKVLSEK 644
++ L +++ L + E+ L R+ Q +RE E ++R + E++ +
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 645 CEAVVAELK--QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKE 702
E LK QE++R + + +HE E +K ++L E+ RRE+W+ K++E
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRK-QQLKRDQEEERRERWL-----KLEE 493
Query: 703 VTVRGLEPEIQKLIARHKQEVR--RLKSLHEAELLQSDERASQRCLRQAEELREQL-ERE 759
R + ++ + R ++E R RLK E E LQ R+ Q+ R+ EE REQL +RE
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 760 KEALGQQERERARQRQRAELEELRQQL-------------EESSSALTRALRAEFEKGRE 806
+E + E+ER QR + E EE R QL E L + L+ E E R
Sbjct: 554 EEK--RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE-EVERL 610
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
EQE R + L + + E +Q ++ + L REQ+ R E R R++E E +
Sbjct: 611 EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ 670
Query: 867 RLE-------ADMALAKEESEKAAESRIKRLRDKYEAEL-SELEQSERKLQERCSELKGQ 918
RL+ + LA+EE E+A E RIK K++ +L SE + + K+ R + +GQ
Sbjct: 671 RLKREHEEERREQELAEEEQEQARE-RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 919 LGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQ 978
E E R + R+ E ++ + + Q E R++F + A EE++ +
Sbjct: 730 RRRQEQEEKRRR---RESELQWQEEERAHRQQQEEEQ------RRDFTWQWQA-EEKSER 779
Query: 979 AKAELATL-----QARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1033
+ L+ Q +QL EE +R + L +EE R Q K LEE
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK-EQRRRQRREREKELQFLEEEE 838
Query: 1034 EQHRR 1038
+ RR
Sbjct: 839 QLQRR 843
Score = 124 bits (312), Expect = 4e-28
Identities = 202/837 (24%), Positives = 350/837 (41%), Gaps = 105/837 (12%)
Query: 252 RRKEVTEEEAERFIHQVN--QATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
RR ++ + E ER ++ Q QR R +V+R R + L + + EE+R++
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ- 632
Query: 310 EGTLLDLHQQKEAARRKAR-EEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRET 368
LL +Q+E +++ R E++ R+ +R +E +++ R ++ ER E E
Sbjct: 633 ---LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Query: 369 RVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSS----------- 417
+ + + +A + P G R +
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 418 ----PEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEEL----LHTLQLLEK 469
QQ E++ +D Q A + E R +R PL E L + ++
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSER---GRQRLSARPPLREQRERQLRAEERQQR 806
Query: 470 EPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSI 529
E LP + R E + L + + + + + EDG LQ
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG-------LQE- 858
Query: 530 MSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
D+ + Q+Q Q+ W E E T + L+ + +K+ LL +
Sbjct: 859 ----DQERRRSQEQRRDQKWRWQLEE-----ERKRRRHTLYAKPALQEQLRKEQQLLQEE 909
Query: 590 ALAQQRDLTARRVKETEKALSR---QLQRQREHY---EATIQRHLAFIDQLIEDKKVLSE 643
QR+ +R ++ ++ R QLQ++ E E +R Q +DKK L +
Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK-LQQ 968
Query: 644 KCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEV 703
K E ++ E + E +R ER + + + EL+ ++ + L EK RR++W + KK +
Sbjct: 969 KEEQLLGE-EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDE-- 1025
Query: 704 TVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEAL 763
L+ E ++L+ R ++E RRL+ +R R+ EEL+++ E++ L
Sbjct: 1026 ----LQQEEEQLL-REEREKRRLQE-------------RERQYREEEELQQE---EEQLL 1064
Query: 764 GQQERERARQ---RQRAELEELRQQLEE-SSSALTRALRAEFEKGREEQERRHQMELNTL 819
G++ R RQ RQ + EEL+Q+ E+ + R E E+ E+E Q E L
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124
Query: 820 KQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLE----ADMALA 875
+++ E R+ + R+EE EQ LREE K R +E+E E + L
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 876 KEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGEN------LRL 929
+EE EK + R ++ R++ E + + +Q R +R S+LK Q E E EN +
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR-SDLKWQ-WEPEKENAVRDNKVYC 1242
Query: 930 QGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQAR 989
+G ++ R LED+Q + Q + +L + Q+ DR E+E R+ +
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHL--LGEQQERDR----EQERRRWQQRDRHFPEE 1296
Query: 990 QQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRAD-----HLEELLEQHRRPTP 1041
+QLE EE + K + +E LR + E +R + EE L Q R P
Sbjct: 1297 EQLEREE-QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Score = 119 bits (297), Expect = 2e-26
Identities = 197/829 (23%), Positives = 345/829 (41%), Gaps = 108/829 (13%)
Query: 259 EEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLL---- 314
+E ER + + ++ R + ++R R + L + REE+ + E LL
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKR-----RRQELERQYREEEEVQQEEEQLLREEP 1158
Query: 315 DLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMR 374
+ +++E R+ EE+ +Q ++E Q+KR ++ E R+ R
Sbjct: 1159 EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Query: 375 QPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQ 434
Q + +L A++ N ++ DS +Q +D Q +L +
Sbjct: 1219 QRS-DLKWQWEPEKENAVRDNKV---YCKGRENEQFRQLEDSQLRDRQSQQD-LQHLLGE 1273
Query: 435 DAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDA 494
D + R + R EE + LE+E + R +++
Sbjct: 1274 QQERDREQERR--RWQQRDRHFPEE-----EQLEREEQKEAKRRDR--------KSQEEK 1318
Query: 495 SSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPE 554
L + EK + + E+ LL E + Q + + +D+ ++E E
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPL-------RRQERDRKFREEELRHQE 1371
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQ 614
G LE + K EE++ ++ L Q RD R+ +E E+ LSRQ +
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD---RKFREEEQQLSRQER 1428
Query: 615 RQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEI 674
++ E R + +E+++ L ++ + ++E+Q ER Q + E +
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHR---KFREEEQLLQEREEQQLHRQERDR 1485
Query: 675 KKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ---EVRRLKSLHE 731
K L+E ++ RR+ E+ +K +E +R EPE +K + +Q + R+ K L E
Sbjct: 1486 KFLEE----EQQLRRQ----ERDRKFREQELRSQEPE-RKFLEEEQQLHRQQRQRKFLQE 1536
Query: 732 AELLQSDERASQRC------LRQAEELREQLEREKEALGQQERERA---------RQRQR 776
+ L+ ER QR R+ E+LR+ ERE++ L +QER+R RQ Q
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQ--EREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 777 AELEELRQQL--EESSSALTRALRAEFEKG------REEQE-RRHQMELNTLKQQLELER 827
+ E QQL +E L + +F + REEQ+ R + + L+++ +L R
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR 1654
Query: 828 QAWEA------GRTRKEEAWLLNR--EQELREEIRKGRDKEIELVIHRLEADMALAKEES 879
Q E R +EE LL EQ+LR + R + +E E + R E + +EE
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 880 EKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
+ + ++ R++ + E EQ + + QER ++ E E LR + +Q R
Sbjct: 1715 QLRRQELERKFREEEQLR-QETEQEQLRRQERYRKI------LEEEQLRPEREEQQLRRQ 1767
Query: 940 LEDAQ-AVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQAR--------- 989
D + EQL ER Q +R + DR EE+ RQ + E +
Sbjct: 1768 ERDRKFREEEQLRQEREE--QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 990 QQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1038
+QL+LEE +R++ R+ A TQ E + + L + EQ RR
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQ-EKSRREEQELWQEEEQKRR 1873
Score = 117 bits (293), Expect = 6e-26
Identities = 128/511 (25%), Positives = 230/511 (45%), Gaps = 68/511 (13%)
Query: 577 VEEKKQAMLLLQRALAQQR--DLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQL 634
++E+K+A + +L Q R + RR + ++ L + ++R +R LA ++
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 635 IEDKKVLSEKCEAVVAE---------LKQEDQRCTERVAQAQAQHELEI------KKLKE 679
E ++ L ++ E ++E++R E Q+ HE E + +E
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 680 LMSATEKARREK-------------------WISEKTKKIKEVT-VRGLEPEIQKLIARH 719
L+ K R EK W +T KE ++ EP+ Q+ +
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAEL 779
++++R+L+ Q +E+ QR LR+ ++LR + E E+ QQE R +Q +R +
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQR-LRREQQLRRKQEEERRE--QQEERREQQERREQQ 331
Query: 780 EELRQQL--EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 837
EE R+Q E + LR E E+ R EQ+ R + E +QQL E+Q + R+
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 838 EEAWLLNREQELREEIRKGRDKEI--------ELVIHRLEADMALAKEESEKAAESRIKR 889
E+ L REQ+LR E + R++++ E + R + + ++ ++ E R+KR
Sbjct: 392 EQQ--LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449
Query: 890 LRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQ 949
+++ L E++ER QER K QL + E R + L ++E E + +Q
Sbjct: 450 EQEERRDWLKREEETERHEQER---RKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Query: 950 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1009
L E+ + E RL EEE R + L++ QQL E+ RR + +E
Sbjct: 507 LRREQ-------EERREQRLKRQEEEERLQQ----RLRSEQQLRREQEERREQLLKREEE 555
Query: 1010 EAVSSLRTQHEAAVKRADHLEELL--EQHRR 1038
+ + R + ++ + ++LL E+ RR
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERR 586
Score = 112 bits (281), Expect = 1e-24
Identities = 196/882 (22%), Positives = 351/882 (39%), Gaps = 136/882 (15%)
Query: 252 RRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEG 311
R++E+ EEE + + ++ + + +R Q Q+R R E L+ K+EE+R+ E
Sbjct: 267 RQRELQEEEEQ--LRKLERQELRRERQEEEQQQQR----LRREQQLRRKQEEERREQQE- 319
Query: 312 TLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVP 371
++++ RR+ +EE+ Q R +E ++++ R Q+ E+ E R
Sbjct: 320 -----ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 372 GMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQ---QPPEDRT 428
+ Q+L Q L+ + E Q + E+R
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 429 QDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWA 488
+ Q+ L+ R R EE Q E+ L R + R R W
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKRE--EETERHEQ--ERRKQQLKRDQEEER-RERWL 489
Query: 489 SEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQ 548
E++ + E+ +L E + L + + + + L + QL +Q
Sbjct: 490 KLEEEERREQQERREQ--QLRREQEERREQRLKRQEEEERLQQRL-----RSEQQLRREQ 542
Query: 549 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA 608
E + E E RLK E EE++ +L + QQ R +E E+
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ-----RLKREQEER 597
Query: 609 LSRQLQRQR-EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQ 667
L ++L+R+ E E +R +Q ++ ++ E+ + ++ +QE++R + + Q
Sbjct: 598 LEQRLKREEVERLEQEERR-----EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652
Query: 668 AQHELEIKKLKE-------LMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI---- 716
+ E +K+ +E L E+ RRE+ ++E+ ++ ++ P+ Q +
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 717 ----------------ARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEE--------- 751
R +QE + E+EL +E + R ++ E+
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ 772
Query: 752 -----------------LREQLEREKEALGQQERER----------ARQRQRAELEELRQ 784
LREQ ER+ A +Q+RE+ R+RQR E E+ Q
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ 832
Query: 785 QLEESSSALTR----ALRAEFEKGREEQERRHQMEL---NTLKQQLELERQAWE------ 831
LEE R L+ E + +E+QERR E + QLE ER+
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 832 ---AGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIK 888
+ RKE+ L E+EL+ E R+ R ++ + +R E L +EE + E R K
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ--LQQEEEQLLREEREK 950
Query: 889 RLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNE 948
R R + E + + ++KLQ++ +L G+ E R + ++E E+ Q + E
Sbjct: 951 RRRQERERQY----RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 949 QLSSERSNLAQVIRQEFE------DRLAASEEETRQAKAELATLQARQQLELEEVHRRVK 1002
+ R RQE+E D L EE+ + + E LQ R++ EE + +
Sbjct: 1007 EREKRR-------RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 1003 TALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1044
EE + R + E ++ + L++ EQ R P +
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Score = 110 bits (275), Expect = 7e-24
Identities = 183/831 (22%), Positives = 338/831 (40%), Gaps = 100/831 (12%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSG 309
L R +++ E+ R Q+ + Q+ R Q RR R E + +R EQR +
Sbjct: 395 LRREQQLRREQQLRREQQLRRE----QQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 310 EGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETR 369
+ D +++E R +E + +Q +R + +++R R K ER + RE +
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKR----DQEEERRERWLKLEEEERREQQERREQQ 506
Query: 370 VPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQ 429
+ ++ +E Q LK +R S + ++ E+R +
Sbjct: 507 LRREQEERRE----------QRLKRQEEE---------ERLQQRLRSEQQLRREQEERRE 547
Query: 430 DVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWAS 489
+L ++ + + R + + EE + +L R + R
Sbjct: 548 QLLKREEE----KRLEQERREQRLKREQEE---------RRDQLLKREEERRQQRLKREQ 594
Query: 490 EEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQE 549
EE L + +E+ + + + E + Q + S +E E+ Q QL +Q+
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS--EEQEERRQQQLRREQQ 652
Query: 550 GWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKAL 609
E L+ E RLK E EE+++ L + Q R+ R+ + + L
Sbjct: 653 ----ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL 708
Query: 610 SRQLQ-RQREHYEATIQRHLAFIDQLIEDKKVLSE-----KCEAVVAELKQEDQRCTERV 663
+ RQ + Y ++ Q E+K+ E + E +QE+++ +
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768
Query: 664 AQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEV 723
Q QA+ + E + + + +RE+ + + ++ +E E E ++ + ++
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 724 RRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELR 783
+ L+ L E E LQ ERA +QL+ E++ L Q+++ER R +++ ++ R
Sbjct: 829 KELQFLEEEEQLQRRERA------------QQLQEEEDGL-QEDQERRRSQEQRRDQKWR 875
Query: 784 QQLEE----------SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAG 833
QLEE + AL LR E + +EE+E + E ++Q E ERQ E
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ-EQERQYREEE 934
Query: 834 RTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 893
+ ++EE LL E+E R + R + + + E + L +E ++ + R K+ R++
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL-LGEEPEKRRRQEREKKYREE 993
Query: 894 YEAELSEL-----EQSERKLQE---------RCSELKGQLGEAEGENLRLQGLVRQKERA 939
E + E E+ +R+ QE + + QL E E RLQ RQ R
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY-RE 1052
Query: 940 LEDAQAVNEQLSSERSNLAQVIRQEFE------DRLAASEEETRQAKAELATLQARQQLE 993
E+ Q EQL E + RQE E + L EE+ + + E Q R++
Sbjct: 1053 EEELQQEEEQLLGEERETRR--RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 994 LEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1044
EE + + +EE R + E + + +++ EQ R P +
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161
Score = 102 bits (255), Expect = 1e-21
Identities = 144/536 (26%), Positives = 239/536 (44%), Gaps = 72/536 (13%)
Query: 537 EKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRD 596
E+ GQ + +QE L G E S RL+ +++ L QR Q+R+
Sbjct: 131 EEPGQRRRQKRQEQ------ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184
Query: 597 --------LTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV 648
L + + ETE+ + R+RE E + E ++ E+ + V
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE-------EKQQQRRERQDRV 237
Query: 649 VAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGL 708
E ++++ R E V + + + KL+E E+ +R++ + E+ ++++++ + L
Sbjct: 238 FQEEEEKEWRKRETVLRKEEE------KLQE-----EEPQRQRELQEEEEQLRKLERQEL 286
Query: 709 -----EPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQ-LEREKEA 762
E E Q+ R +Q++RR K E Q + R Q Q EE REQ L RE+E
Sbjct: 287 RRERQEEEQQQQRLRREQQLRR-KQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 763 LGQQERERARQRQRAELEELRQQLEESSSALTRA---LRAEFEKGREEQERRHQM----E 815
+Q+ R ++ +R E + R+Q EE R LR E + RE+Q RR Q +
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 816 LNTLKQQLELERQA---WEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADM 872
+QQL E+Q + R ++EE EQE RE+ K +E D
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE--------RRDW 457
Query: 873 ALAKEESEKAAESRIK-RLRDKYEAELSE----LEQSERKLQERCSELKGQLGEAEGENL 927
+EE+E+ + R K +L+ E E E LE+ ER+ Q+ E + Q E E
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ---ERREQQLRREQEER 514
Query: 928 RLQGLVRQ-KERALEDAQAVNEQLSSER-SNLAQVIRQEFEDRLAASEEETRQAKAELAT 985
R Q L RQ +E L+ +QL E+ Q++++E E RL E+E R+ + +
Sbjct: 515 REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL---EQERREQRLKREQ 571
Query: 986 LQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTP 1041
+ R QL E RR + +EE + + E V+R + E ++ +R P
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREE--VERLEQEERREQRLKREEP 625
Score = 79.7 bits (195), Expect = 1e-14
Identities = 169/778 (21%), Positives = 298/778 (38%), Gaps = 116/778 (14%)
Query: 189 RYTPSERAPPLKSSNQTAPSLNNIIK--AATCEGSESSGFGKLPKNVSSATHSARNNTGG 246
RY ++ LK Q P N ++ C+G E+ F +L S ++
Sbjct: 1213 RYRDEDQRSDLKW--QWEPEKENAVRDNKVYCKGRENEQFRQLE---DSQLRDRQSQQDL 1267
Query: 247 STGLPRRKEVTEEEAERFIHQVNQ---ATVTIQRWYRHQVQRRGAGAARLEHLLQAKREE 303
L ++E E+ R Q ++ ++R + + +RR + + LL+ +REE
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 304 QRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAA-IQELQQKRALRAQKASTAERGPP 362
+R+R +E R+ EE+ Q R ++ ++ R R ++ E+G
Sbjct: 1328 KRRR------------QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 363 ENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQ 422
E R+ + + L Q L+ L DR + + +
Sbjct: 1376 FLEEEQRLRRQERERKFLKE------EQQLRCQEREQQLRQ----DRDRKFREEEQQLSR 1425
Query: 423 PPEDRT-----QDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP 477
DR Q V Q+ LE R + EE L L E+E L R
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL----LQEREEQQLHRQ 1481
Query: 478 RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKL---QSIMSFLD 534
+ + EE D KF + + PE L E +L Q FL
Sbjct: 1482 ERDRK----FLEEEQQLRRQERDR--KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 535 E-----MEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
E ++ GQ + + + E ++S K +EE+K
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV------- 1588
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVV 649
+R R+ E E+ L RQ +Q+ E R +QL+++++ +
Sbjct: 1589 ----RRQEQERKFMEDEQQLRRQEGQQQLRQER--DRKFREDEQLLQEREEQQLHRQERD 1642
Query: 650 AELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLE 709
+ +E+ + + + Q +H+ + K +E E ++ E+ +K +E
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFRE------- 1695
Query: 710 PEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREK--------- 760
E Q+L +++ R K L E + L+ E +R R+ E+LR++ E+E+
Sbjct: 1696 -EEQQL----RRQERERKFLQEEQQLRRQEL--ERKFREEEQLRQETEQEQLRRQERYRK 1748
Query: 761 ---------EALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERR 811
E QQ R + R R+ E E+LRQ+ EE + R K REE++ R
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR----KFREEEQLR 1804
Query: 812 HQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHR--LE 869
+ E L+ Q + WE +E+ L +EQ LR+E + E +
Sbjct: 1805 QEREEQQLRPQQRDGKYRWE-----EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 870 ADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENL 927
+ L +EE +K + R ++LR+++ + EQ R++ E+K Q G+ G L
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV----GEIKSQEGKGHGRLL 1913
Score = 69.7 bits (169), Expect = 1e-11
Identities = 81/315 (25%), Positives = 130/315 (41%), Gaps = 50/315 (15%)
Query: 761 EALGQQERERAR--------QRQRAELEELR-----QQLEESSSALTRALR-------AE 800
+A G E +RAR Q +R E ++ R +QLEE R R AE
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 801 FEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLN---------------- 844
E+ E+QER Q + ++L +RQ W+ R+ E L
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 845 REQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQS 904
R +EL E RKGR+++ + R E + +EE EK R LR + E E Q
Sbjct: 211 RRRELLELRRKGREEKQQ---QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 905 ERKLQERCSELK----------GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSER 954
+R+LQE +L+ Q E + + LR + +R+K+ E + E+ +
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE-ERREQQEERREQQE 326
Query: 955 SNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSS 1014
Q R+E + R E +Q + E + QQL E+ R + L R+++
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 1015 LRTQHEAAVKRADHL 1029
+ + E ++R L
Sbjct: 387 QQLRREQQLRREQQL 401
Score = 60.8 bits (146), Expect = 6e-09
Identities = 73/301 (24%), Positives = 144/301 (47%), Gaps = 36/301 (11%)
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEA 647
Q+ Q+RD R+ E E L RQ + Q+ ++ R +QL+++ + + +
Sbjct: 1634 QQLHRQERD---RKFLEEEPQLRRQEREQQLRHDR--DRKFREEEQLLQEGEEQQLRRQE 1688
Query: 648 VVAELKQEDQRCTERVAQA---QAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVT 704
+ ++E+Q+ + + Q + +L ++L+ E+ R+E +E+ + ++
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE---TEQEQLRRQER 1745
Query: 705 VRGLEPEIQKLIARHKQEVRR------------LKSLHEAELLQSDERASQRCLRQAEEL 752
R + E Q R +Q++RR L+ E + L+S E S R R+ E+L
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQE--SDRKFREEEQL 1803
Query: 753 REQLEREKEALGQQERERAR--QRQRAELEELRQQLEESSSALTRALRAEFEKGREEQER 810
R+ ERE++ L Q+R+ + ++ +LEE Q+L + R RAE + +E+ R
Sbjct: 1804 RQ--EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD---RQYRAEEQFATQEKSR 1858
Query: 811 RHQMEL---NTLKQQLELERQAWEAGRTRKEEAWLLNRE-QELREEIRKGRDKEIELVIH 866
R + EL K++ E ER+ E R+++ +R+ E++ + KG + +E H
Sbjct: 1859 REEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTH 1918
Query: 867 R 867
+
Sbjct: 1919 Q 1919
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 115 bits (288), Expect = 2e-25
Identities = 115/441 (26%), Positives = 214/441 (48%), Gaps = 44/441 (9%)
Query: 576 EVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLI 635
E+E+ K+A+ + Q + ++ TE A R L+ + +A +R L D+
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR-LEVNMQAMKAQFERDLQTRDEQN 1587
Query: 636 EDKK-VLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWIS 694
E+KK +L ++ + AEL+ E ++ VA ++ + E+++K L+ + A KAR E +
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVA-SKKKMEIDLKDLEAQIEAANKARDE--VI 1644
Query: 695 EKTKKIKEVTVRGLEPEIQK-------LIARHKQEVRRLKSLHEAELLQSDER--ASQRC 745
++ +K+ + ++ + E+++ + A+ K+ ++LKSL EAE+LQ E +S+R
Sbjct: 1645 KQLRKL-QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL-EAEILQLQEELASSERA 1702
Query: 746 LRQAEELREQLERE--KEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEK 803
R AE+ R++L E A G+ ++R A + +L ++LEE S +
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL------- 1755
Query: 804 GREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR-EEIRKGRDKEIE 862
++ R+ ++++TL +L ER A + +++ N+E + + +E+ + +
Sbjct: 1756 --NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFK 1813
Query: 863 LVIHRLEADMALAKEESEKAAESR------IKRLRDKYEAELSELEQSER---------- 906
I LEA + +E+ E+ A+ R ++R K + ++E R
Sbjct: 1814 ATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME 1873
Query: 907 KLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFE 966
K R +LK QL EAE E R R+ +R L+DA NE LS E S L +R+
Sbjct: 1874 KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP 1933
Query: 967 DRLAASEEETRQAKAELATLQ 987
++S RQ E A+L+
Sbjct: 1934 ISFSSSRSGRRQLHLEGASLE 1954
Score = 103 bits (257), Expect = 8e-22
Identities = 126/571 (22%), Positives = 260/571 (45%), Gaps = 69/571 (12%)
Query: 516 EDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL-- 573
++ L + K + L+EME+ Q L+ ++ + E EL +E RL
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLE--EKNILAEQLQAETELFAEAEEMRARLAA 915
Query: 574 --------------KLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREH 619
++E EE++ +L ++ Q + E+ ++LQ ++
Sbjct: 916 KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT 975
Query: 620 YEATIQRH----LAFIDQ---LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHEL 672
EA I++ L DQ I++KK++ ++ ++L +E+++ + +A+ + + E+
Sbjct: 976 AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA-KNLAKIRNKQEV 1034
Query: 673 EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKL----------IARHKQE 722
I L+E + EK R+E EK K+ + L+ +I +L +A+ ++E
Sbjct: 1035 MISDLEERLKKEEKTRQEL---EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091
Query: 723 VRRLKSLHEAELLQSDE--RASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELE 780
++ + + E L + + + Q EL+E E EK + + E+++ + ELE
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE--ELE 1149
Query: 781 ELRQQLEES--SSALTRALR-------AEFEKGREEQERRHQMELNTLKQQ--LELERQA 829
L+ +LE++ ++A + LR AE +K EE+ + H+ ++ ++Q+ LE +
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELS 1209
Query: 830 WEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKR 889
+ + ++ +A L +Q L + +KE+ + L+ A E K +++++
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETD-----NKELACEVKVLQQVKA-ESEHKRKKLDAQVQE 1263
Query: 890 LRDKY-EAELSELEQSER--KLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 946
L K E + +E +E+ KLQ + L EAE + ++ E L+D Q +
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL 1323
Query: 947 NEQLSSERSNLAQVIRQ--EFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTA 1004
++ + ++ NL+ IRQ E ++ L +EE +A+ L Q +L + ++V
Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 1005 LARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
L + SL + +K A+ L + LE+
Sbjct: 1384 LG----TIESLEEAKKKLLKDAEALSQRLEE 1410
Score = 99.8 bits (247), Expect = 1e-20
Identities = 195/855 (22%), Positives = 336/855 (39%), Gaps = 131/855 (15%)
Query: 252 RRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEG 311
+++E T +E E+ +++ T +Q Q+ A L+ L K EE + G
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQ----DQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 312 TLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVP 371
LH K A + RE +A+ I ELQ+ ++KAS + + +
Sbjct: 1100 DDETLH--KNNALKVVRELQAQ------IAELQED--FESEKASRNKAEKQKRDLSEELE 1149
Query: 372 GMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDV 431
++ ++ T K L A ++ Q + R +
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQEVAELKKA-------LEEETKNHEAQIQDMRQRHA 1202
Query: 432 LAQDAAGDNLEMMAPSRGSA-KSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASE 490
A + + LE + + K++ LE L K + H R + +
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 491 EDDASSLTADNL-----EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLD 545
E A D L EK KL E TLL EA+ + I D S + QL
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQN--ELDNVSTLLEEAEKKGIKFAKDAA--SLESQLQ 1318
Query: 546 SQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKET 605
QE + E L L S + ++EE+K + L +Q++ K
Sbjct: 1319 DTQE-LLQEETRQKLNLSSRIR--------QLEEEKNS-------LQEQQEEEEEARKNL 1362
Query: 606 EKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQED------QRC 659
EK + LQ Q + + L I+ L E KK L + EA+ L+++ ++
Sbjct: 1363 EKQVLA-LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 660 TERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARH 719
R+ Q +++ +++ S EK ++K + + K ++ R E + A
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEK--KQKKFDQLLAEEKSISARYAEERDR---AEA 1476
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELR---EQLEREKEALGQQ--ERERARQR 774
+ + K+L A L+ A + RQ ++LR E L K+ +G+ E E++++
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 775 QRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGR 834
++EE+R QLEE L + E+ + R ++ + +K Q E + Q +
Sbjct: 1537 LEQQVEEMRTQLEELEDEL---------QATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 835 TRKEEAWLLNREQELREEIRKGRD---------KEIELVIHRLEADMALAKEESEKAAES 885
K+ L+ + +EL E+ R K++E+ + LEA + E + KA +
Sbjct: 1588 EEKKRL-LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI----EAANKARDE 1642
Query: 886 RIKRLRD------KYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
IK+LR Y+ EL E S ++ + E + +L E E L+LQ + ERA
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 940 LEDAQAVNEQLSSERSNLAQVI------RQEFEDRLAASEEETRQAKAEL---------A 984
A+ ++L+ E +N A ++ E R+A EEE + ++ +
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 985 TLQ--------------------ARQQLELEEVHRRVKTALARKEEAV-SSLRTQHEAAV 1023
TLQ ARQQLE + ++ +K L E AV S + A
Sbjct: 1763 TLQVDTLNAELAAERSAAQKSDNARQQLERQ--NKELKAKLQELEGAVKSKFKATISALE 1820
Query: 1024 KRADHLEELLEQHRR 1038
+ LEE LEQ +
Sbjct: 1821 AKIGQLEEQLEQEAK 1835
Score = 95.1 bits (235), Expect = 3e-19
Identities = 107/396 (27%), Positives = 191/396 (48%), Gaps = 44/396 (11%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKW--ISEKTKKIKEVTVRGLEPEIQKLIAR 718
R A A+ Q +L +K L+ +A K R +W + K K + +VT + E E+Q A+
Sbjct: 803 RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQ--EEELQ---AK 857
Query: 719 HKQ--EVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQR 776
++ +V+ ++ E EL + ER Q+ L + L EQL+ E E + E RAR
Sbjct: 858 DEELLKVKEKQTKVEGEL-EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR---- 912
Query: 777 AELEELRQQLEESSSALTRALRAEFEKGR--EEQERRHQMELNTLKQQLELERQAWEAGR 834
L +Q+LEE L + E E+ + + ++++ Q + L++QL+ E A + +
Sbjct: 913 --LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 835 TRK--EEAWLLNREQE--LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRL 890
K EA + E+E L E+ KE +L+ R+ + EE EKA + ++
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA--KNLAKI 1028
Query: 891 RDKYEAELS--------------ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQK 936
R+K E +S ELE+++RKL ++L+ Q+ E + + L+ + +K
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 937 ERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEE 996
E L+ A A + + ++N +V+R E + ++A +E+ KA + +Q+ +L E
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVR-ELQAQIAELQEDFESEKASRNKAE-KQKRDLSE 1146
Query: 997 VHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEEL 1032
+KT L E+ + + Q E KR + EL
Sbjct: 1147 ELEALKTEL---EDTLDTTAAQQELRTKREQEVAEL 1179
Score = 86.7 bits (213), Expect = 1e-16
Identities = 117/481 (24%), Positives = 218/481 (45%), Gaps = 75/481 (15%)
Query: 593 QQRDLTARRVKETEKALSRQLQR-QREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
Q +D +VKE + + +L+ +R+H QL+E+K +L+E+ +A
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKH------------QQLLEEKNILAEQLQAETEL 902
Query: 652 LKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPE 711
+ ++ A+ Q E+ L +L S E+ I + KK + ++ LE +
Sbjct: 903 FAEAEEMRARLAAKKQELEEI----LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 712 I-------QKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALG 764
+ QKL ++K + E LL D+ + + +++ + + +++ L
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ--NSKFIKEKKLMEDRIAECSSQLA 1016
Query: 765 QQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQE---RRHQMELNTLKQ 821
++E E+A+ L ++R + E S L L+ E EK R+E E R+ E L+
Sbjct: 1017 EEE-EKAK-----NLAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDLQD 1069
Query: 822 QL-ELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIE-----LVIHRLEADMALA 875
Q+ EL+ Q E + L +E+EL+ + +G D+ + V+ L+A +A
Sbjct: 1070 QIAELQAQIDEL------KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 876 KE--ESEKA----AESRIKRLRDKYEAELSELEQS----------ERKLQERCSELKGQL 919
+E ESEKA AE + + L ++ EA +ELE + K ++ +ELK L
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 920 -GEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFE---DRLAASEEE 975
E + ++Q + ++ ALE+ EQ ++NL + +Q E LA +
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL-EKNKQGLETDNKELACEVKV 1242
Query: 976 TRQAKAELATLQARQQLELEEVHRRVKTA-LARKEEAVSSLRTQHEAAVKRADHLEELLE 1034
+Q KAE + + +++E+H +V R E A + + Q+E D++ LLE
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE-----LDNVSTLLE 1297
Query: 1035 Q 1035
+
Sbjct: 1298 E 1298
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 113 bits (282), Expect = 1e-24
Identities = 131/492 (26%), Positives = 238/492 (48%), Gaps = 62/492 (12%)
Query: 574 KLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQR---HLAF 630
+LE EE+ A L +R + ++ + K + +++++ E ++ +A
Sbjct: 974 RLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAA 1033
Query: 631 IDQ----LIEDKKVLSEKCEAVVAELKQEDQRCTE------RVAQAQAQHELEIKKLKEL 680
+D+ L ++KK L E + + +L+ E+ R + R+ Q E +++ K+L
Sbjct: 1034 LDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKL 1093
Query: 681 MSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL----HEAELLQ 736
TE+A+R+ E K+ + +V + Q+L + K++ L L + +LL
Sbjct: 1094 RMDTERAKRKL---EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLG 1150
Query: 737 SDERASQRCLR-QAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTR 795
+ + + L+ +AEEL E+LE E+ A + E++RA + ELEEL ++LEE+ A
Sbjct: 1151 AQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAAR--ELEELSERLEEAGGA--- 1205
Query: 796 ALRAEFEKGREEQERRHQMELNTLKQQLE---LERQAWEAGRTRK--EEAWLLNREQELR 850
G+ E R+ + EL L+++LE L +A A RK E A L + +
Sbjct: 1206 ------SAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL 1259
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
+ +R+ +KE + R+E D A E+ A++ ++L YE +LSE +
Sbjct: 1260 QRVRQKLEKEKSEL--RMEVDDLAANVETLTRAKASAEKLCRTYEDQLSE-------AKI 1310
Query: 911 RCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLA 970
+ EL+ QL +A + RLQ + R LE+ + + QLS ++ AQ + + L
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSL-----EELR 1365
Query: 971 ASEEETRQAKAELA-TLQA--------RQQLELE-EVHRRVKTALARKEEAVSSLRTQHE 1020
EE +AK+ LA +QA R+Q E E E ++ L++ V+ R+++E
Sbjct: 1366 RQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425
Query: 1021 A-AVKRADHLEE 1031
A A++R + LEE
Sbjct: 1426 ADAIQRTEELEE 1437
Score = 99.0 bits (245), Expect = 2e-20
Identities = 132/514 (25%), Positives = 215/514 (41%), Gaps = 69/514 (13%)
Query: 562 LGSEVSTSVMRLKL---EVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQRE 618
LG+++ + L+ E+EE+ +A + + +QR AR ++E + L
Sbjct: 1149 LGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAG 1208
Query: 619 HYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLK 678
E +R A + +L + + + + EA VA L+++ A+ A+ ++ L+
Sbjct: 1209 QREGCRKRE-AELGRLRRELEEAALRHEATVAALRRKQ-------AEGAAELGEQVDSLQ 1260
Query: 679 ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSD 738
+ EK + E + T+ + +KL ++ ++ K E Q
Sbjct: 1261 RVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320
Query: 739 ERASQRCLRQAE--ELREQLEREKEALGQQERERARQRQRAELEELRQQLEESS---SAL 793
+ ++QR Q E EL LE ++ + Q R +A Q LEELR+QLEE S SAL
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQ--SLEELRRQLEEESKAKSAL 1378
Query: 794 TRALRA-----EFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
A++A + + + E+E Q EL L + E W + K EA + R +E
Sbjct: 1379 AHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS----KYEADAIQRTEE 1434
Query: 849 LREEIRK----------------GRDKEIELVIHRLEA---DMALAKEESEKAAESRIKR 889
L E +K + +E RL+ D+ L E + AA + K+
Sbjct: 1435 LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494
Query: 890 LRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV--- 946
R A LE+ R+ +E EL+ E+ G L L E ALE + +
Sbjct: 1495 QRHLERA----LEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRE 1550
Query: 947 NEQLSSERSNLAQVIR------QEFEDRLAASEEETRQAKAELA----------TLQARQ 990
N+ L E S+L + QE E A E E + +A L T R
Sbjct: 1551 NKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRI 1610
Query: 991 QLELEEVHRRVKTALARKEEAVSSLRTQHEAAVK 1024
QLEL +V V LA K+E ++LR H+ AV+
Sbjct: 1611 QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVE 1644
Score = 92.8 bits (229), Expect = 1e-18
Identities = 195/881 (22%), Positives = 357/881 (40%), Gaps = 164/881 (18%)
Query: 254 KEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTL 313
K+ EE+ ++ +++Q ++ ++ Q GA + LQA+ EE
Sbjct: 1122 KQQLEEKLKKKDSELSQLSLRVE-----DEQLLGAQMQKKIKELQARAEE---------- 1166
Query: 314 LDLHQQKEAARR-KAREEKARQARRAAIQELQQKRALRAQKASTAERGPPEN--PRETRV 370
L ++ EA R +AR EK R ++EL + R ++A A G E RE +
Sbjct: 1167 --LEEELEAERAARARVEKQRAEAARELEELSE----RLEEAGGASAGQREGCRKREAEL 1220
Query: 371 PGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQD 430
+R+ +E + T AL+ G AA G++ DS +Q E +
Sbjct: 1221 GRLRRELEEAALRHEATV-AALRRKQAEG---AAELGEQV----DSLQRVRQKLEKEKSE 1272
Query: 431 VLAQ-DAAGDNLEMMAPSRGSA-KSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWA 488
+ + D N+E + ++ SA K E+ L ++ +E + RGR
Sbjct: 1273 LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ-- 1330
Query: 489 SEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQ 548
+E + S L + +LS G L+ L+ + L+E K+ + Q
Sbjct: 1331 TESGELSRLLEEKECLISQLSR-------GKALAAQSLEELRRQLEEESKAKSALAHAVQ 1383
Query: 549 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA 608
+ L+ + EE+ +A LQR L++ A+ + E
Sbjct: 1384 A----------------LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE-- 1425
Query: 609 LSRQLQRQREHYEATIQRHLAF-IDQLIEDKKVLSEKC---EAVVAELKQEDQRCTERVA 664
+ +QR E EA ++ LA + + E + + KC E L+ E + T +
Sbjct: 1426 -ADAIQRTEELEEA--KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELE 1482
Query: 665 QAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVR 724
+A + KK + L A E+ RR++ ++ + + RGL E+ +L H++ +
Sbjct: 1483 RATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALE 1542
Query: 725 RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQ 784
L++L +R ++ + +L +Q+ +++ QE E+ ++ E E++
Sbjct: 1543 ALETL---------KRENKNLQEEISDLTDQVSLSGKSI--QELEKTKKALEGEKSEIQA 1591
Query: 785 QLEESSSAL----TRALRAEFEKGREEQE----------------RRHQMELNTLKQQLE 824
LEE+ AL T+ LR + E + + E R HQ + +L+ L+
Sbjct: 1592 ALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLD 1651
Query: 825 LERQAW-EAGRTRKEEAWLLN----------------------REQELREEIRKGRDKEI 861
E +A EA R +K+ LN + +L+EE + GRD+E
Sbjct: 1652 AETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEE-QAGRDEEQ 1710
Query: 862 ELVIHRLEADMALAKEESEKAAE-----------SRIKRLRDKYEAELSE---------- 900
L E AL + S AAE R +RL ++ E +E
Sbjct: 1711 RLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNT 1770
Query: 901 -LEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQ 959
L ++KL+ ++L G++ EA E + + ++A+ DA + E+L E+ A
Sbjct: 1771 GLLNQKKKLEADLAQLSGEVEEAAQERREAE---EKAKKAITDAAMMAEELKKEQDTSAH 1827
Query: 960 VIR---------QEFEDRLAASEEET-RQAKAELATLQAR-QQLELE-----EVHRRVKT 1003
+ R +E + RL +E+ R K ++ L+A+ ++LE E + H
Sbjct: 1828 LERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALK 1887
Query: 1004 ALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1044
+ + E V L Q E K +++L+++ + S K
Sbjct: 1888 GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYK 1928
Score = 82.0 bits (201), Expect = 3e-15
Identities = 174/774 (22%), Positives = 296/774 (38%), Gaps = 81/774 (10%)
Query: 228 KLPKNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRH------ 281
KL K S + L R K E+ + Q+++A + ++ R
Sbjct: 1265 KLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADAST 1324
Query: 282 QVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQ 341
Q R + L LL+ K Q S G L +E R+ E KA+ A A+Q
Sbjct: 1325 QRGRLQTESGELSRLLEEKECLISQLS-RGKALAAQSLEELRRQLEEESKAKSALAHAVQ 1383
Query: 342 ELQQKRALRAQKASTAERGPPENPR----------ETRVPGMRQPAQELSPTPGGTAHQA 391
L+ L ++ E R + R Q A
Sbjct: 1384 ALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA 1443
Query: 392 LKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAP--SRG 449
L+ G+ AA +C + Q ED T ++ +A L+ R
Sbjct: 1444 LRLQEAEEGVEAANA--KCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERA 1501
Query: 450 SAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNL-EKFGKL 508
+ R EE+ L+ ++E L R + A E + NL E+ L
Sbjct: 1502 LEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDL 1561
Query: 509 SAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVST 568
+ D LS +Q + E K + S+ + + EA G LEL T
Sbjct: 1562 T-------DQVSLSGKSIQEL-----EKTKKALEGEKSEIQAALEEA-EGALELEE---T 1605
Query: 569 SVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHL 628
+R++LE+ + K + R LA++ + A L R QR E +A++
Sbjct: 1606 KTLRIQLELSQVKAEV---DRKLAEKDEECAN--------LRRNHQRAVESLQASLDAET 1654
Query: 629 AFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKAR 688
++ + KK K E + +L+ + T + +AQA L +LKE + ++ +
Sbjct: 1655 RARNEALRLKK----KMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ 1710
Query: 689 REKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQ 748
R + + E L E+++L A +Q R + L E ELL++ ER + +
Sbjct: 1711 RLAAELHEQAQALERRASLLAAELEELRAALEQG-ERSRRLAEQELLEATERLNLLHSQN 1769
Query: 749 AEEL--REQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
L +++LE + L + E A++R+ AE E++ A+T A E +E
Sbjct: 1770 TGLLNQKKKLEADLAQLSGEVEEAAQERREAE--------EKAKKAITDAAMMAEELKKE 1821
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ H L +K+ LE + +A E+A L ++++++ K R+ E EL
Sbjct: 1822 QDTSAH---LERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAE 1878
Query: 867 RLEADMALAKEESEKAAESRIKRLRDKYEAE-----LSELEQSERKLQERCSELKGQLGE 921
+ + AL + + E R+K L Y+AE L+ ++ KLQ + K Q E
Sbjct: 1879 QKKHAEAL---KGVRKHERRVKELA--YQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEE 1933
Query: 922 AEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEE 975
AE + R+ + L+DA E+ + A +R D L +E
Sbjct: 1934 AEQQANTNLAKYRKAQHELDDA----EERADMAETQANKLRARTRDALGPKHKE 1983
Score = 68.9 bits (167), Expect = 2e-11
Identities = 79/318 (24%), Positives = 137/318 (43%), Gaps = 33/318 (10%)
Query: 746 LRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGR 805
LR A+ E E G + A + +R ELEE + + + L L+AE +
Sbjct: 889 LRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA 948
Query: 806 EEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVI 865
+ +ER H + +K +++LE + E ++E + +L RK D+ EL
Sbjct: 949 DAEERCHLL----IKSKVQLEGKVKELSERLEDEEEV---NADLAARRRKLEDECTELKK 1001
Query: 866 HRLEADMALAKEESEK-AAESRIKRLRDKYEA---ELSELEQSERKLQERCSELKGQLGE 921
+ + LAK E EK A E+++K L ++ A ++ L + ++ LQE + G L
Sbjct: 1002 DIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQA 1061
Query: 922 AEGE-------NLRLQGLVRQKERALE-------DAQAVNEQLSSERSNLAQVIRQEFED 967
E LRL+ V E +LE D + +L + + + +D
Sbjct: 1062 EEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQD 1121
Query: 968 RLAASEEETRQAKAELATLQAR---QQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVK 1024
+ EE+ ++ +EL+ L R +QL ++ +++K AR EE L + A +
Sbjct: 1122 K-QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARAR 1180
Query: 1025 ----RADHLEELLEQHRR 1038
RA+ EL E R
Sbjct: 1181 VEKQRAEAARELEELSER 1198
Score = 67.0 bits (162), Expect = 9e-11
Identities = 95/398 (23%), Positives = 172/398 (43%), Gaps = 61/398 (15%)
Query: 666 AQAQHEL-----EIKKLKELMSATEKARRE------KWISEKTK-----KIKEVTVRGLE 709
AQA+ EL E++ L+ ++A E R+E EK + ++ + E
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE 951
Query: 710 PEIQKLIARHKQEVRRLKSLHEA----ELLQSDERASQRCLR-QAEELREQLEREKEALG 764
LI Q ++K L E E + +D A +R L + EL++ ++ K L
Sbjct: 952 ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLA 1011
Query: 765 QQERER-ARQRQRAELEELRQQLEESSSALTR---ALRAEFEKGREEQERRHQMELNTLK 820
+ E+E+ A + + L E L+ES + LT+ AL+ ++ + + K
Sbjct: 1012 KAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTK 1071
Query: 821 QQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESE 880
+L LE+Q ++ L +E++LR + + + K LE D+ L +E
Sbjct: 1072 AKLRLEQQV-------EDLECSLEQEKKLRMDTERAKRK--------LEGDLKLTQESVA 1116
Query: 881 KAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERAL 940
AA+ + +Q E KL+++ SEL E E L + ++ +
Sbjct: 1117 DAAQDK---------------QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161
Query: 941 EDAQAVNEQLSSERSNLAQVIRQEFE-----DRLAASEEETRQAKAELATLQARQQLELE 995
A+ + E+L +ER+ A+V +Q E + L+ EE A A +++ EL
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221
Query: 996 EVHRRVKTALARKEEAVSSL-RTQHEAAVKRADHLEEL 1032
+ R ++ A R E V++L R Q E A + + ++ L
Sbjct: 1222 RLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL 1259
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 111 bits (277), Expect = 4e-24
Identities = 108/487 (22%), Positives = 228/487 (46%), Gaps = 48/487 (9%)
Query: 566 VSTSVMRLKLEVEEKKQAMLLLQRALA---QQRDLTARRVKETEKALSR--------QLQ 614
+S + R + EE K+ LQ L ++ VKE ++ L R QLQ
Sbjct: 205 LSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQ 264
Query: 615 RQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEI 674
+ +H +Q A + +E+ ++ + + ++ +++++ E + Q Q E
Sbjct: 265 AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR 324
Query: 675 KKLKELMSATEKARR-EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL---H 730
++ +++ EK RR E+ + EK +K++ ++++ ++++RRL+ +
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQ---------EEMMWEKEEKMRRLEEMMWEK 375
Query: 731 EAELLQSDERA-SQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEES 789
E ++ + +E+ Q +R+ EE R++ E+ +E +QE+E RQ ++ E +++ E
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 435
Query: 790 SSALTRALRA--EFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQ 847
+ R E EK REE++R+ Q E+ ++++ + + W E+ + +E+
Sbjct: 436 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495
Query: 848 ELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERK 907
++ + K D+E ++ +E+ EK +++R++ E ++ E E+ R+
Sbjct: 496 KVWRQEEKMHDQEEKI------------REQEEKMWRQE-EKIREQ-EEKIREQEEKIRE 541
Query: 908 LQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFED 967
+E E + ++GE E + + + RQ+E+ E + + EQ R ++ QE +
Sbjct: 542 QEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKI 601
Query: 968 RLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAV----SSLRTQHEAAV 1023
R +EE Q + E Q + E EE + + + R+EE + LR Q E
Sbjct: 602 R---EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 658
Query: 1024 KRADHLE 1030
+ +HLE
Sbjct: 659 EHQEHLE 665
Score = 101 bits (251), Expect = 4e-21
Identities = 120/539 (22%), Positives = 255/539 (47%), Gaps = 67/539 (12%)
Query: 438 GDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSL 497
G+ ++++ S K G LE+ L + +K+ D T R S E +++
Sbjct: 158 GEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDAL---SLELYRNTI 214
Query: 498 TADNL-EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAG 556
T + L EK KL E L+ K + ++ + K + +L Q+ EA
Sbjct: 215 TDEELKEKNAKLQ------EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 268
Query: 557 PGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTAR---RVKETEKALSRQL 613
LG E+ + +L+ +VEE + L R QQ + R +++E E+ + Q
Sbjct: 269 ----HLGKELQSVSAKLQAQVEENE----LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 614 QRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAV--VAELKQEDQRCTERVAQAQAQHE 671
++ RE E ++ +++ ++++ EK E + E+ E + R+ + + E
Sbjct: 321 EKIREQEEKIREQE----EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKE 376
Query: 672 LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG------------LEPEIQKLIARH 719
+I++L+E M EK R ++ ++ +KI+E R + + +K+ +
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 720 KQEVRRLKSLHEAELLQSDERASQR--CLRQAEELREQLE--REKEALGQQERERARQ-- 773
K+ R+ + +HE E ++ +E+ ++ RQ E++REQ E R+KE + +QE+ R ++
Sbjct: 437 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK 496
Query: 774 --RQRAELEELRQQLEESSSALTRA---LRAEFEKGREEQERRHQMELNTLKQQLEL--- 825
RQ ++ + +++ E + R +R + EK RE++E+ + E +Q+ ++
Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQ 556
Query: 826 ERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAES 885
E + E + R++E + +E+++RE+ K R++E ++ +EE + E
Sbjct: 557 EEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI----------WEQEEKIREQEE 606
Query: 886 RIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 944
++ +K + ++ + E K+QE+ +++ Q + + +RL RQ+E +++ Q
Sbjct: 607 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL----RQQEEKMQEHQ 661
Score = 66.2 bits (160), Expect = 1e-10
Identities = 79/341 (23%), Positives = 160/341 (46%), Gaps = 48/341 (14%)
Query: 561 ELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHY 620
E+ E + RL+ + EK++ + L+ + +Q + + K E+ R+ Q +R+
Sbjct: 356 EMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQ 414
Query: 621 EATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHEL-------- 672
EA + R I + +++K+ ++ + E K +Q + Q Q E+
Sbjct: 415 EAKMWRQEEKIRE--QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 472
Query: 673 ---EIKKLKELMSATEKARREK---WISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRL 726
EI + KE M EK R+++ W E+ +E +R E ++ + R ++++R
Sbjct: 473 EQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIR----EQEEKMWRQEEKIRE- 527
Query: 727 KSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQL 786
E ++ + +E+ + Q E ++EQ E+ E Q+E+ + +++ R + E++R+Q
Sbjct: 528 ---QEEKIREQEEKIRE----QEEMMQEQEEKMGE---QEEKMQEQEKMRRQEEKIREQE 577
Query: 787 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQ---LELERQAWEAGRTRKEEAWLL 843
E+ +R + EK RE++E+ + E +Q+ E E + WE E+
Sbjct: 578 EK--------IREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQE--- 626
Query: 844 NREQELREEIRKGRDK--EIELVIHRLEADMALAKEESEKA 882
+ QE E++R+ +K E E+ + + E M +E E A
Sbjct: 627 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 47.4 bits (111), Expect = 7e-05
Identities = 84/365 (23%), Positives = 145/365 (39%), Gaps = 49/365 (13%)
Query: 696 KTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLR----QAEE 751
K KKI G PE H E + S E L+ + A +R Q E
Sbjct: 86 KKKKINN----GTNPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTE 141
Query: 752 LREQLEREKEALGQQERERARQRQRA-ELEELRQQLEESSSALTRALRAEFEKGREEQER 810
L+ L + A+ Q E E R + + +LE++ SA+ ++++
Sbjct: 142 LQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVAT---------QKKKAD 192
Query: 811 RHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEA 870
R+ EL + L LE R + L + +L+E+++ ++ E+ ++
Sbjct: 193 RYIEELTKERDALSLELY-----RNTITDEELKEKNAKLQEKLQLVESEKSEIQLN---- 243
Query: 871 DMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQ 930
KE K +++ + + +AE L ++LQ ++L+ Q+ E E N Q
Sbjct: 244 ----VKELKRKLERAKLLLPQQQLQAEADHLG---KELQSVSAKLQAQVEENELWNRLNQ 296
Query: 931 G----LVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATL 986
+ RQ+E+ E + + EQ R ++ QE + R +EE K E
Sbjct: 297 QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR---RQEEMMWEKEEKMRR 353
Query: 987 QARQQLELEEVHRRVKTALARKEEAVSSLRTQ-------HEAAVKRADHLEELLEQHRRP 1039
Q E EE RR++ + KEE + L + E KR + E++ EQ +R
Sbjct: 354 QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE-EKIREQEKRQ 412
Query: 1040 TPSTK 1044
K
Sbjct: 413 EQEAK 417
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 110 bits (275), Expect = 7e-24
Identities = 209/788 (26%), Positives = 318/788 (40%), Gaps = 121/788 (15%)
Query: 328 REEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGT 387
R+++ QAR +Q++Q+ Q+ S E G + RV + + L+
Sbjct: 874 RQDEVLQARAQELQKVQE-----LQQQSAREVGELQG----RVAQLEEERARLAEQLRAE 924
Query: 388 AHQALKANNTGGGLPA---------------AGPGDRCLPTSDSSPEP-QQPPEDRTQDV 431
A +A T G L A G + C + + QQ ++ +
Sbjct: 925 AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 984
Query: 432 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAW---- 487
A++ A L++ + AK + E+LL LLE + L + R R A
Sbjct: 985 EAEEGARQKLQLEKVTT-EAKMKKFEEDLL----LLEDQNSKLSKERKLLEDRLAEFSSQ 1039
Query: 488 -ASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEA---KLQSIMSFLDEMEKSGQDQ 543
A EE+ SL L K A ED E +L+ + LD Q+Q
Sbjct: 1040 AAEEEEKVKSLNKLRL----KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQ 1095
Query: 544 LDSQQEGWVPEAGPGPLELG---SEVSTSVMRLKLEVEEKKQAMLLL---QRALAQ-QRD 596
+ QQ+ A +LG E+ ++ R + E + Q + L Q ALA+ Q D
Sbjct: 1096 MVEQQQ----RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1151
Query: 597 LTARRVKETE-----KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
L + RV T+ + L +L+ R E T+ A ++ L K E V E
Sbjct: 1152 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA--------QQELRSKREQEVTE 1203
Query: 652 LK---QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGL 708
LK +E+ R E Q Q + L EL E+ARR K EKT+ E V L
Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1261
Query: 709 EPEIQKL-IARHKQEVRRLK---SLHEAELLQSD-ERASQRCLRQAEELREQLEREKEAL 763
E+ L AR + E RR + L E + D ERA + + + +LE AL
Sbjct: 1262 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1321
Query: 764 GQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQL 823
+ E + R + EL QL ++ L RA+ G + R + E L++QL
Sbjct: 1322 NEAESKTIRLSK--ELSSTEAQLHDAQELLQEETRAKLALG--SRVRAMEAEAAGLREQL 1377
Query: 824 ELERQAWE-AGRTRKE-----EAWLLNREQ-----ELREEIRKGRDKEIELVIHRLEADM 872
E E A E AGR + W +E+ E EE R+ +E E + RL A+
Sbjct: 1378 EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL-AEK 1436
Query: 873 ALAKEESEKAAESRIKRLRD------KYEAELSELEQSERKLQERCSELKGQLGEAEGEN 926
+ E+ + L D + +S LE+ +RK + +E K + A E
Sbjct: 1437 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1496
Query: 927 LRLQGLVRQKE-------RALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE----- 974
R + R++E RALE+ Q E+L ER N A +R E E L++ ++
Sbjct: 1497 ERAEAEGREREARALSLTRALEEEQEAREEL--ERQNRA--LRAELEALLSSKDDVGKSV 1552
Query: 975 ---ETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLE 1030
E AE A R Q+ ELE+ + A R E V +L+TQHE ++ D
Sbjct: 1553 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD--- 1609
Query: 1031 ELLEQHRR 1038
E E+ RR
Sbjct: 1610 EAGEERRR 1617
Score = 98.2 bits (243), Expect = 4e-20
Identities = 186/798 (23%), Positives = 321/798 (40%), Gaps = 118/798 (14%)
Query: 298 QAKREEQRQRSGEGTLLDLHQQKEAARR-KAREEKARQARRAAIQELQQKRALRAQKAST 356
+A +E RQR G+ L +L +Q E ARR K EK R A A + EL RA + +
Sbjct: 1216 EAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRLALEAEVSEL---RAELSSLQTA 1271
Query: 357 AERGPPENPR-ETRVPGMRQPAQELSPTPGGTAHQALKAN----NTGGGLPAAGPGDRCL 411
+ G R E ++ ++ A + A + +A N G L A L
Sbjct: 1272 RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1331
Query: 412 PTSDSSPEPQ--QPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEK 469
SS E Q E ++ A+ A G + M A++ G E+L
Sbjct: 1332 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-----EAEAAGLREQL--------- 1377
Query: 470 EPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSI 529
E + R R + A A S E+ G L A E +EA Q +
Sbjct: 1378 EEEAAARERAGRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL 1433
Query: 530 MSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
+ +++ + + QQE ++L + R + EKKQ +
Sbjct: 1434 AEKTETVDRLERGRRRLQQE-----LDDATMDLEQQ------RQLVSTLEKKQRKF--DQ 1480
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEAT--IQRHLAFIDQLIEDKKVLSEKCEA 647
LA+++ R V+E E+A + +R+ T ++ ++L + L + EA
Sbjct: 1481 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1540
Query: 648 V------VAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIK 701
+ V + E +R QA ++ +L++ ++A E A+
Sbjct: 1541 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRL---------- 1590
Query: 702 EVTVRGLEPEIQKLIARHKQ--EVRR---LKSLHEAELLQSDERASQRCLRQAEELR--- 753
EVTV+ L+ + ++ + + E RR K L +AE+ + DE QR L A +
Sbjct: 1591 EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV-ERDEERKQRTLAVAARKKLEG 1649
Query: 754 --EQLEREKEALGQQERERARQ--RQRAELEELRQQLEESSSALTRALRAE-FEKGREEQ 808
E+L+ + + GQ + E +Q + +A+++EL +++EE TR R E F + RE +
Sbjct: 1650 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE-----TRTSREEIFSQNRESE 1704
Query: 809 ERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRL 868
+R +E L+ Q EL + R R++ E+ +E+ G + ++ +
Sbjct: 1705 KRLKGLEAEVLRLQEELAA----SDRARRQAQ---QDRDEMADEVANGNLSKAAILEEKR 1757
Query: 869 EADMALAKEESEKAAE-SRIKRLRDKYE----------AELS-------ELEQSERKLQE 910
+ + L + E E E S + L D+Y ELS + E ++L+
Sbjct: 1758 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1817
Query: 911 RCSELKGQLGEAE-GENLRLQGLVRQKERALEDAQAVNEQLSSER-----------SNLA 958
+ EL+G+LGE + G R + + E L A+ EQ + ER L
Sbjct: 1818 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1877
Query: 959 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAVSSLRT 1017
+V+ Q E+R A + + K L Q ++QL E EE R + R + + +
Sbjct: 1878 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTE 1937
Query: 1018 QHEAAVKRADHLEELLEQ 1035
E+ + L L +
Sbjct: 1938 SAESMNREVTTLRNRLRR 1955
Score = 87.0 bits (214), Expect = 8e-17
Identities = 117/438 (26%), Positives = 189/438 (43%), Gaps = 85/438 (19%)
Query: 662 RVAQAQAQHELEIKKLKELMSATEKARREKW--ISEKTKKIKEVTVRGLEPEIQKLIARH 719
R Q + Q + ++ ++ +A K R +W + K K + +VT + E+ + A+
Sbjct: 829 RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVT---RQDEVLQARAQE 885
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAEL 779
Q+V+ L+ E+ + R +Q +A L EQL E E + E R R R
Sbjct: 886 LQKVQELQQQSAREVGELQGRVAQLEEERAR-LAEQLRAEAELCAEAEETRGRLAAR--- 941
Query: 780 EELRQQLEESSSALTRALRAEFEKGREEQ--ERRHQMELNTL----------KQQLELER 827
+Q+LE S L + E E R+ Q ++R Q + L +Q+L+LE+
Sbjct: 942 ---KQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 998
Query: 828 QAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRI 887
EA + EE LL +Q + KE +L+ RL + A EE EK +
Sbjct: 999 VTTEAKMKKFEEDLLLLEDQNSK------LSKERKLLEDRLAEFSSQAAEEEEKVKS--L 1050
Query: 888 KRLRDKYEAELS--------------ELEQSERKL--------------QERCSELKGQL 919
+LR KYEA ++ ELE+ +R+L Q+R EL+ QL
Sbjct: 1051 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1110
Query: 920 GEAE--------------GENLRLQGLVRQKERALEDAQAVNEQLSSER--SNLAQVIRQ 963
G E G +L +R+ + AL +AQ E L SER A+ R+
Sbjct: 1111 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ---EDLESERVARTKAEKQRR 1167
Query: 964 EFEDRLAASE---EETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
+ + L A E+T + L+++++ E+ E+ + ++ E AV LR +H
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 1021 AAVKRADHLEELLEQHRR 1038
A+ L E LEQ RR
Sbjct: 1228 QAL---GELAEQLEQARR 1242
Score = 75.1 bits (183), Expect = 3e-13
Identities = 173/780 (22%), Positives = 308/780 (39%), Gaps = 139/780 (17%)
Query: 231 KNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGA 290
+NVS A + A + T + E +A+ + + +A + + R
Sbjct: 1315 ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1374
Query: 291 ARLEHLLQAKREEQRQ-RSGEGTLLDLH--QQKEAARRKAREEKARQARRAAIQELQQKR 347
+LE A+ R+ ++ + L + Q++EA +A EE R+A R A + L Q+
Sbjct: 1375 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-EALTQRL 1433
Query: 348 ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPG 407
A + + ER G R+ QEL Q
Sbjct: 1434 AEKTETVDRLER------------GRRRLQQELDDATMDLEQQRQLV------------- 1468
Query: 408 DRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
S+ E +Q D+ +LA++ A + R A+ R L + L
Sbjct: 1469 --------STLEKKQRKFDQ---LLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1517
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
E+E + +R A E +A + D++ K E ++E
Sbjct: 1518 EEEQEAREELERQNRALRA----ELEALLSSKDDVGK------SVHELERACRVAEQAAN 1567
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLL 587
+ + + E+E D+L + ++ + + +V LK + E Q
Sbjct: 1568 DLRAQVTELE----DELTAAEDAKL------------RLEVTVQALKTQHERDLQGR--- 1608
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEA 647
A ++R A+++++ E ++R E + T+ + +K L + E
Sbjct: 1609 DEAGEERRRQLAKQLRDAE------VERDEERKQRTL---------AVAARKKLEGELEE 1653
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG 707
+ A++ Q E V Q + ++KEL E+ R + + E ++G
Sbjct: 1654 LKAQMASAGQGKEEAVKQLRKMQ----AQMKELWREVEETRTSREEIFSQNRESEKRLKG 1709
Query: 708 LEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQE 767
LE E+ +L R + + +DE A+ L +A L E+ + E LGQ E
Sbjct: 1710 LEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN-LSKAAILEEKRQLEGR-LGQLE 1767
Query: 768 RERARQRQRAEL-----EELRQQLEESSSALT--RALRAEFEKGREEQERRHQMELNTL- 819
E ++ +EL +L Q+E ++ L+ R+ A+ E GR++ ER+ Q L
Sbjct: 1768 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1827
Query: 820 ------KQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 873
+ + ++ A E+ + EE EQE RE I G K + RL+ ++
Sbjct: 1828 EEDAGARARHKMTIAALESKLAQAEE----QLEQETRERILSG--KLVRRAEKRLK-EVV 1880
Query: 874 LAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLV 933
L EE + A+ +LRD+ E K R +LK QL EAE E R Q
Sbjct: 1881 LQVEEERRVAD----QLRDQLE-----------KGNLRVKQLKRQLEEAEEEASRAQAGR 1925
Query: 934 RQKERALED----AQAVNEQLSSERSNL--------AQVIRQEFE-DRLAASEEETRQAK 980
R+ +R LED A+++N ++++ R+ L + +RQ F + AS+EE +A+
Sbjct: 1926 RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1985
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 110 bits (275), Expect = 7e-24
Identities = 209/788 (26%), Positives = 318/788 (40%), Gaps = 121/788 (15%)
Query: 328 REEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGT 387
R+++ QAR +Q++Q+ Q+ S E G + RV + + L+
Sbjct: 866 RQDEVLQARAQELQKVQE-----LQQQSAREVGELQG----RVAQLEEERARLAEQLRAE 916
Query: 388 AHQALKANNTGGGLPA---------------AGPGDRCLPTSDSSPEP-QQPPEDRTQDV 431
A +A T G L A G + C + + QQ ++ +
Sbjct: 917 AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 976
Query: 432 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAW---- 487
A++ A L++ + AK + E+LL LLE + L + R R A
Sbjct: 977 EAEEGARQKLQLEKVTT-EAKMKKFEEDLL----LLEDQNSKLSKERKLLEDRLAEFSSQ 1031
Query: 488 -ASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEA---KLQSIMSFLDEMEKSGQDQ 543
A EE+ SL L K A ED E +L+ + LD Q+Q
Sbjct: 1032 AAEEEEKVKSLNKLRL----KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQ 1087
Query: 544 LDSQQEGWVPEAGPGPLELG---SEVSTSVMRLKLEVEEKKQAMLLL---QRALAQ-QRD 596
+ QQ+ A +LG E+ ++ R + E + Q + L Q ALA+ Q D
Sbjct: 1088 MVEQQQ----RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1143
Query: 597 LTARRVKETE-----KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
L + RV T+ + L +L+ R E T+ A ++ L K E V E
Sbjct: 1144 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA--------QQELRSKREQEVTE 1195
Query: 652 LK---QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGL 708
LK +E+ R E Q Q + L EL E+ARR K EKT+ E V L
Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1253
Query: 709 EPEIQKL-IARHKQEVRRLK---SLHEAELLQSD-ERASQRCLRQAEELREQLEREKEAL 763
E+ L AR + E RR + L E + D ERA + + + +LE AL
Sbjct: 1254 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1313
Query: 764 GQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQL 823
+ E + R + EL QL ++ L RA+ G + R + E L++QL
Sbjct: 1314 NEAESKTIRLSK--ELSSTEAQLHDAQELLQEETRAKLALG--SRVRAMEAEAAGLREQL 1369
Query: 824 ELERQAWE-AGRTRKE-----EAWLLNREQ-----ELREEIRKGRDKEIELVIHRLEADM 872
E E A E AGR + W +E+ E EE R+ +E E + RL A+
Sbjct: 1370 EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL-AEK 1428
Query: 873 ALAKEESEKAAESRIKRLRD------KYEAELSELEQSERKLQERCSELKGQLGEAEGEN 926
+ E+ + L D + +S LE+ +RK + +E K + A E
Sbjct: 1429 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1488
Query: 927 LRLQGLVRQKE-------RALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE----- 974
R + R++E RALE+ Q E+L ER N A +R E E L++ ++
Sbjct: 1489 ERAEAEGREREARALSLTRALEEEQEAREEL--ERQNRA--LRAELEALLSSKDDVGKSV 1544
Query: 975 ---ETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLE 1030
E AE A R Q+ ELE+ + A R E V +L+TQHE ++ D
Sbjct: 1545 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD--- 1601
Query: 1031 ELLEQHRR 1038
E E+ RR
Sbjct: 1602 EAGEERRR 1609
Score = 98.2 bits (243), Expect = 4e-20
Identities = 186/798 (23%), Positives = 321/798 (40%), Gaps = 118/798 (14%)
Query: 298 QAKREEQRQRSGEGTLLDLHQQKEAARR-KAREEKARQARRAAIQELQQKRALRAQKAST 356
+A +E RQR G+ L +L +Q E ARR K EK R A A + EL RA + +
Sbjct: 1208 EAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRLALEAEVSEL---RAELSSLQTA 1263
Query: 357 AERGPPENPR-ETRVPGMRQPAQELSPTPGGTAHQALKAN----NTGGGLPAAGPGDRCL 411
+ G R E ++ ++ A + A + +A N G L A L
Sbjct: 1264 RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1323
Query: 412 PTSDSSPEPQ--QPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEK 469
SS E Q E ++ A+ A G + M A++ G E+L
Sbjct: 1324 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-----EAEAAGLREQL--------- 1369
Query: 470 EPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSI 529
E + R R + A A S E+ G L A E +EA Q +
Sbjct: 1370 EEEAAARERAGRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL 1425
Query: 530 MSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
+ +++ + + QQE ++L + R + EKKQ +
Sbjct: 1426 AEKTETVDRLERGRRRLQQE-----LDDATMDLEQQ------RQLVSTLEKKQRKF--DQ 1472
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEAT--IQRHLAFIDQLIEDKKVLSEKCEA 647
LA+++ R V+E E+A + +R+ T ++ ++L + L + EA
Sbjct: 1473 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1532
Query: 648 V------VAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIK 701
+ V + E +R QA ++ +L++ ++A E A+
Sbjct: 1533 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRL---------- 1582
Query: 702 EVTVRGLEPEIQKLIARHKQ--EVRR---LKSLHEAELLQSDERASQRCLRQAEELR--- 753
EVTV+ L+ + ++ + + E RR K L +AE+ + DE QR L A +
Sbjct: 1583 EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV-ERDEERKQRTLAVAARKKLEG 1641
Query: 754 --EQLEREKEALGQQERERARQ--RQRAELEELRQQLEESSSALTRALRAE-FEKGREEQ 808
E+L+ + + GQ + E +Q + +A+++EL +++EE TR R E F + RE +
Sbjct: 1642 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE-----TRTSREEIFSQNRESE 1696
Query: 809 ERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRL 868
+R +E L+ Q EL + R R++ E+ +E+ G + ++ +
Sbjct: 1697 KRLKGLEAEVLRLQEELAA----SDRARRQAQ---QDRDEMADEVANGNLSKAAILEEKR 1749
Query: 869 EADMALAKEESEKAAE-SRIKRLRDKYE----------AELS-------ELEQSERKLQE 910
+ + L + E E E S + L D+Y ELS + E ++L+
Sbjct: 1750 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1809
Query: 911 RCSELKGQLGEAE-GENLRLQGLVRQKERALEDAQAVNEQLSSER-----------SNLA 958
+ EL+G+LGE + G R + + E L A+ EQ + ER L
Sbjct: 1810 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1869
Query: 959 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAVSSLRT 1017
+V+ Q E+R A + + K L Q ++QL E EE R + R + + +
Sbjct: 1870 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTE 1929
Query: 1018 QHEAAVKRADHLEELLEQ 1035
E+ + L L +
Sbjct: 1930 SAESMNREVTTLRNRLRR 1947
Score = 87.0 bits (214), Expect = 8e-17
Identities = 117/438 (26%), Positives = 189/438 (43%), Gaps = 85/438 (19%)
Query: 662 RVAQAQAQHELEIKKLKELMSATEKARREKW--ISEKTKKIKEVTVRGLEPEIQKLIARH 719
R Q + Q + ++ ++ +A K R +W + K K + +VT + E+ + A+
Sbjct: 821 RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVT---RQDEVLQARAQE 877
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAEL 779
Q+V+ L+ E+ + R +Q +A L EQL E E + E R R R
Sbjct: 878 LQKVQELQQQSAREVGELQGRVAQLEEERAR-LAEQLRAEAELCAEAEETRGRLAAR--- 933
Query: 780 EELRQQLEESSSALTRALRAEFEKGREEQ--ERRHQMELNTL----------KQQLELER 827
+Q+LE S L + E E R+ Q ++R Q + L +Q+L+LE+
Sbjct: 934 ---KQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 990
Query: 828 QAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRI 887
EA + EE LL +Q + KE +L+ RL + A EE EK +
Sbjct: 991 VTTEAKMKKFEEDLLLLEDQNSK------LSKERKLLEDRLAEFSSQAAEEEEKVKS--L 1042
Query: 888 KRLRDKYEAELS--------------ELEQSERKL--------------QERCSELKGQL 919
+LR KYEA ++ ELE+ +R+L Q+R EL+ QL
Sbjct: 1043 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1102
Query: 920 GEAE--------------GENLRLQGLVRQKERALEDAQAVNEQLSSER--SNLAQVIRQ 963
G E G +L +R+ + AL +AQ E L SER A+ R+
Sbjct: 1103 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ---EDLESERVARTKAEKQRR 1159
Query: 964 EFEDRLAASE---EETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
+ + L A E+T + L+++++ E+ E+ + ++ E AV LR +H
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 1021 AAVKRADHLEELLEQHRR 1038
A+ L E LEQ RR
Sbjct: 1220 QAL---GELAEQLEQARR 1234
Score = 75.1 bits (183), Expect = 3e-13
Identities = 173/780 (22%), Positives = 308/780 (39%), Gaps = 139/780 (17%)
Query: 231 KNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGA 290
+NVS A + A + T + E +A+ + + +A + + R
Sbjct: 1307 ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1366
Query: 291 ARLEHLLQAKREEQRQ-RSGEGTLLDLH--QQKEAARRKAREEKARQARRAAIQELQQKR 347
+LE A+ R+ ++ + L + Q++EA +A EE R+A R A + L Q+
Sbjct: 1367 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-EALTQRL 1425
Query: 348 ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPG 407
A + + ER G R+ QEL Q
Sbjct: 1426 AEKTETVDRLER------------GRRRLQQELDDATMDLEQQRQLV------------- 1460
Query: 408 DRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
S+ E +Q D+ +LA++ A + R A+ R L + L
Sbjct: 1461 --------STLEKKQRKFDQ---LLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1509
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
E+E + +R A E +A + D++ K E ++E
Sbjct: 1510 EEEQEAREELERQNRALRA----ELEALLSSKDDVGK------SVHELERACRVAEQAAN 1559
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLL 587
+ + + E+E D+L + ++ + + +V LK + E Q
Sbjct: 1560 DLRAQVTELE----DELTAAEDAKL------------RLEVTVQALKTQHERDLQGR--- 1600
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEA 647
A ++R A+++++ E ++R E + T+ + +K L + E
Sbjct: 1601 DEAGEERRRQLAKQLRDAE------VERDEERKQRTL---------AVAARKKLEGELEE 1645
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG 707
+ A++ Q E V Q + ++KEL E+ R + + E ++G
Sbjct: 1646 LKAQMASAGQGKEEAVKQLRKMQ----AQMKELWREVEETRTSREEIFSQNRESEKRLKG 1701
Query: 708 LEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQE 767
LE E+ +L R + + +DE A+ L +A L E+ + E LGQ E
Sbjct: 1702 LEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN-LSKAAILEEKRQLEGR-LGQLE 1759
Query: 768 RERARQRQRAEL-----EELRQQLEESSSALT--RALRAEFEKGREEQERRHQMELNTL- 819
E ++ +EL +L Q+E ++ L+ R+ A+ E GR++ ER+ Q L
Sbjct: 1760 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1819
Query: 820 ------KQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 873
+ + ++ A E+ + EE EQE RE I G K + RL+ ++
Sbjct: 1820 EEDAGARARHKMTIAALESKLAQAEE----QLEQETRERILSG--KLVRRAEKRLK-EVV 1872
Query: 874 LAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLV 933
L EE + A+ +LRD+ E K R +LK QL EAE E R Q
Sbjct: 1873 LQVEEERRVAD----QLRDQLE-----------KGNLRVKQLKRQLEEAEEEASRAQAGR 1917
Query: 934 RQKERALED----AQAVNEQLSSERSNL--------AQVIRQEFE-DRLAASEEETRQAK 980
R+ +R LED A+++N ++++ R+ L + +RQ F + AS+EE +A+
Sbjct: 1918 RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 1977
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 110 bits (275), Expect = 7e-24
Identities = 209/788 (26%), Positives = 318/788 (40%), Gaps = 121/788 (15%)
Query: 328 REEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGT 387
R+++ QAR +Q++Q+ Q+ S E G + RV + + L+
Sbjct: 907 RQDEVLQARAQELQKVQE-----LQQQSAREVGELQG----RVAQLEEERARLAEQLRAE 957
Query: 388 AHQALKANNTGGGLPA---------------AGPGDRCLPTSDSSPEP-QQPPEDRTQDV 431
A +A T G L A G + C + + QQ ++ +
Sbjct: 958 AELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHL 1017
Query: 432 LAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAW---- 487
A++ A L++ + AK + E+LL LLE + L + R R A
Sbjct: 1018 EAEEGARQKLQLEKVTT-EAKMKKFEEDLL----LLEDQNSKLSKERKLLEDRLAEFSSQ 1072
Query: 488 -ASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEA---KLQSIMSFLDEMEKSGQDQ 543
A EE+ SL L K A ED E +L+ + LD Q+Q
Sbjct: 1073 AAEEEEKVKSLNKLRL----KYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQ 1128
Query: 544 LDSQQEGWVPEAGPGPLELG---SEVSTSVMRLKLEVEEKKQAMLLL---QRALAQ-QRD 596
+ QQ+ A +LG E+ ++ R + E + Q + L Q ALA+ Q D
Sbjct: 1129 MVEQQQ----RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQED 1184
Query: 597 LTARRVKETE-----KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAE 651
L + RV T+ + L +L+ R E T+ A ++ L K E V E
Sbjct: 1185 LESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA--------QQELRSKREQEVTE 1236
Query: 652 LK---QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGL 708
LK +E+ R E Q Q + L EL E+ARR K EKT+ E V L
Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQA--LGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1294
Query: 709 EPEIQKL-IARHKQEVRRLK---SLHEAELLQSD-ERASQRCLRQAEELREQLEREKEAL 763
E+ L AR + E RR + L E + D ERA + + + +LE AL
Sbjct: 1295 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGAL 1354
Query: 764 GQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQL 823
+ E + R + EL QL ++ L RA+ G + R + E L++QL
Sbjct: 1355 NEAESKTIRLSK--ELSSTEAQLHDAQELLQEETRAKLALG--SRVRAMEAEAAGLREQL 1410
Query: 824 ELERQAWE-AGRTRKE-----EAWLLNREQ-----ELREEIRKGRDKEIELVIHRLEADM 872
E E A E AGR + W +E+ E EE R+ +E E + RL A+
Sbjct: 1411 EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL-AEK 1469
Query: 873 ALAKEESEKAAESRIKRLRD------KYEAELSELEQSERKLQERCSELKGQLGEAEGEN 926
+ E+ + L D + +S LE+ +RK + +E K + A E
Sbjct: 1470 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1529
Query: 927 LRLQGLVRQKE-------RALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE----- 974
R + R++E RALE+ Q E+L ER N A +R E E L++ ++
Sbjct: 1530 ERAEAEGREREARALSLTRALEEEQEAREEL--ERQNRA--LRAELEALLSSKDDVGKSV 1585
Query: 975 ---ETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLE 1030
E AE A R Q+ ELE+ + A R E V +L+TQHE ++ D
Sbjct: 1586 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRD--- 1642
Query: 1031 ELLEQHRR 1038
E E+ RR
Sbjct: 1643 EAGEERRR 1650
Score = 98.2 bits (243), Expect = 4e-20
Identities = 186/798 (23%), Positives = 321/798 (40%), Gaps = 118/798 (14%)
Query: 298 QAKREEQRQRSGEGTLLDLHQQKEAARR-KAREEKARQARRAAIQELQQKRALRAQKAST 356
+A +E RQR G+ L +L +Q E ARR K EK R A A + EL RA + +
Sbjct: 1249 EAAVQELRQRHGQA-LGELAEQLEQARRGKGAWEKTRLALEAEVSEL---RAELSSLQTA 1304
Query: 357 AERGPPENPR-ETRVPGMRQPAQELSPTPGGTAHQALKAN----NTGGGLPAAGPGDRCL 411
+ G R E ++ ++ A + A + +A N G L A L
Sbjct: 1305 RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1364
Query: 412 PTSDSSPEPQ--QPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEK 469
SS E Q E ++ A+ A G + M A++ G E+L
Sbjct: 1365 SKELSSTEAQLHDAQELLQEETRAKLALGSRVRAM-----EAEAAGLREQL--------- 1410
Query: 470 EPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSI 529
E + R R + A A S E+ G L A E +EA Q +
Sbjct: 1411 EEEAAARERAGRELQTAQAQ----LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL 1466
Query: 530 MSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQR 589
+ +++ + + QQE ++L + R + EKKQ +
Sbjct: 1467 AEKTETVDRLERGRRRLQQE-----LDDATMDLEQQ------RQLVSTLEKKQRKF--DQ 1513
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEAT--IQRHLAFIDQLIEDKKVLSEKCEA 647
LA+++ R V+E E+A + +R+ T ++ ++L + L + EA
Sbjct: 1514 LLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1573
Query: 648 V------VAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIK 701
+ V + E +R QA ++ +L++ ++A E A+
Sbjct: 1574 LLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRL---------- 1623
Query: 702 EVTVRGLEPEIQKLIARHKQ--EVRR---LKSLHEAELLQSDERASQRCLRQAEELR--- 753
EVTV+ L+ + ++ + + E RR K L +AE+ + DE QR L A +
Sbjct: 1624 EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV-ERDEERKQRTLAVAARKKLEG 1682
Query: 754 --EQLEREKEALGQQERERARQ--RQRAELEELRQQLEESSSALTRALRAE-FEKGREEQ 808
E+L+ + + GQ + E +Q + +A+++EL +++EE TR R E F + RE +
Sbjct: 1683 ELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE-----TRTSREEIFSQNRESE 1737
Query: 809 ERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRL 868
+R +E L+ Q EL + R R++ E+ +E+ G + ++ +
Sbjct: 1738 KRLKGLEAEVLRLQEELAA----SDRARRQAQ---QDRDEMADEVANGNLSKAAILEEKR 1790
Query: 869 EADMALAKEESEKAAE-SRIKRLRDKYE----------AELS-------ELEQSERKLQE 910
+ + L + E E E S + L D+Y ELS + E ++L+
Sbjct: 1791 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1850
Query: 911 RCSELKGQLGEAE-GENLRLQGLVRQKERALEDAQAVNEQLSSER-----------SNLA 958
+ EL+G+LGE + G R + + E L A+ EQ + ER L
Sbjct: 1851 QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLK 1910
Query: 959 QVIRQEFEDRLAASEEETRQAKAELATLQARQQL-ELEEVHRRVKTALARKEEAVSSLRT 1017
+V+ Q E+R A + + K L Q ++QL E EE R + R + + +
Sbjct: 1911 EVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTE 1970
Query: 1018 QHEAAVKRADHLEELLEQ 1035
E+ + L L +
Sbjct: 1971 SAESMNREVTTLRNRLRR 1988
Score = 87.0 bits (214), Expect = 8e-17
Identities = 117/438 (26%), Positives = 189/438 (43%), Gaps = 85/438 (19%)
Query: 662 RVAQAQAQHELEIKKLKELMSATEKARREKW--ISEKTKKIKEVTVRGLEPEIQKLIARH 719
R Q + Q + ++ ++ +A K R +W + K K + +VT + E+ + A+
Sbjct: 862 RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVT---RQDEVLQARAQE 918
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAEL 779
Q+V+ L+ E+ + R +Q +A L EQL E E + E R R R
Sbjct: 919 LQKVQELQQQSAREVGELQGRVAQLEEERAR-LAEQLRAEAELCAEAEETRGRLAAR--- 974
Query: 780 EELRQQLEESSSALTRALRAEFEKGREEQ--ERRHQMELNTL----------KQQLELER 827
+Q+LE S L + E E R+ Q ++R Q + L +Q+L+LE+
Sbjct: 975 ---KQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 1031
Query: 828 QAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRI 887
EA + EE LL +Q + KE +L+ RL + A EE EK +
Sbjct: 1032 VTTEAKMKKFEEDLLLLEDQNSK------LSKERKLLEDRLAEFSSQAAEEEEKVKS--L 1083
Query: 888 KRLRDKYEAELS--------------ELEQSERKL--------------QERCSELKGQL 919
+LR KYEA ++ ELE+ +R+L Q+R EL+ QL
Sbjct: 1084 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1143
Query: 920 GEAE--------------GENLRLQGLVRQKERALEDAQAVNEQLSSER--SNLAQVIRQ 963
G E G +L +R+ + AL +AQ E L SER A+ R+
Sbjct: 1144 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ---EDLESERVARTKAEKQRR 1200
Query: 964 EFEDRLAASE---EETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHE 1020
+ + L A E+T + L+++++ E+ E+ + ++ E AV LR +H
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 1021 AAVKRADHLEELLEQHRR 1038
A+ L E LEQ RR
Sbjct: 1261 QAL---GELAEQLEQARR 1275
Score = 75.1 bits (183), Expect = 3e-13
Identities = 173/780 (22%), Positives = 308/780 (39%), Gaps = 139/780 (17%)
Query: 231 KNVSSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGA 290
+NVS A + A + T + E +A+ + + +A + + R
Sbjct: 1348 ENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1407
Query: 291 ARLEHLLQAKREEQRQ-RSGEGTLLDLH--QQKEAARRKAREEKARQARRAAIQELQQKR 347
+LE A+ R+ ++ + L + Q++EA +A EE R+A R A + L Q+
Sbjct: 1408 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-EALTQRL 1466
Query: 348 ALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPG 407
A + + ER G R+ QEL Q
Sbjct: 1467 AEKTETVDRLER------------GRRRLQQELDDATMDLEQQRQLV------------- 1501
Query: 408 DRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLL 467
S+ E +Q D+ +LA++ A + R A+ R L + L
Sbjct: 1502 --------STLEKKQRKFDQ---LLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1550
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
E+E + +R A E +A + D++ K E ++E
Sbjct: 1551 EEEQEAREELERQNRALRA----ELEALLSSKDDVGK------SVHELERACRVAEQAAN 1600
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLL 587
+ + + E+E D+L + ++ + + +V LK + E Q
Sbjct: 1601 DLRAQVTELE----DELTAAEDAKL------------RLEVTVQALKTQHERDLQGR--- 1641
Query: 588 QRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEA 647
A ++R A+++++ E ++R E + T+ + +K L + E
Sbjct: 1642 DEAGEERRRQLAKQLRDAE------VERDEERKQRTL---------AVAARKKLEGELEE 1686
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG 707
+ A++ Q E V Q + ++KEL E+ R + + E ++G
Sbjct: 1687 LKAQMASAGQGKEEAVKQLRKMQ----AQMKELWREVEETRTSREEIFSQNRESEKRLKG 1742
Query: 708 LEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQE 767
LE E+ +L R + + +DE A+ L +A L E+ + E LGQ E
Sbjct: 1743 LEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN-LSKAAILEEKRQLEGR-LGQLE 1800
Query: 768 RERARQRQRAEL-----EELRQQLEESSSALT--RALRAEFEKGREEQERRHQMELNTL- 819
E ++ +EL +L Q+E ++ L+ R+ A+ E GR++ ER+ Q L
Sbjct: 1801 EELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1860
Query: 820 ------KQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 873
+ + ++ A E+ + EE EQE RE I G K + RL+ ++
Sbjct: 1861 EEDAGARARHKMTIAALESKLAQAEE----QLEQETRERILSG--KLVRRAEKRLK-EVV 1913
Query: 874 LAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLV 933
L EE + A+ +LRD+ E K R +LK QL EAE E R Q
Sbjct: 1914 LQVEEERRVAD----QLRDQLE-----------KGNLRVKQLKRQLEEAEEEASRAQAGR 1958
Query: 934 RQKERALED----AQAVNEQLSSERSNL--------AQVIRQEFE-DRLAASEEETRQAK 980
R+ +R LED A+++N ++++ R+ L + +RQ F + AS+EE +A+
Sbjct: 1959 RRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEEAQ 2018
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 110 bits (275), Expect = 7e-24
Identities = 135/560 (24%), Positives = 263/560 (46%), Gaps = 69/560 (12%)
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGS-----EVSTSVMRLKLEVEE 579
+L+ S L E + Q+QL ++ E + EA + L + E M +LE EE
Sbjct: 877 ELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 580 KKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----LAFIDQ-- 633
+ L +R Q+ L E E+A ++LQ ++ EA I++ L DQ
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 634 -LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW 692
L +++K+L E+ + L +E+++ + + + + +HE I +L+ + EK+R+E
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKA-KNLTKLKNKHESMISELEVRLKKEEKSRQEL- 1053
Query: 693 ISEKTKKIKEVTVRGLEPEIQKL---IARHKQEVRRLKSLHEAELLQSDERASQRC---- 745
EK K+ E +I L IA K ++ + + +A L + D+ +Q+
Sbjct: 1054 --EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 746 -LRQAE----ELREQLEREKEALGQQERERARQRQRAELEELRQQLEES--SSALTRALR 798
+R+ E +L+E L+ E+ A + E+++ + ELE L+ +LE++ S+A + LR
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE--ELEALKTELEDTLDSTATQQELR 1169
Query: 799 AEFE-------KGREEQERRHQMELNTLKQQ--LELERQAWEAGRTRKEEAWLLNREQEL 849
A+ E K +E+ R H+ ++ ++Q+ +E + + ++ +A L +Q L
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 850 REEIRKGRDKEIELVIHRLEADMALAKEESE---KAAESRIKRLRDKY---EAELSELEQ 903
+E D EL + + AK+E E K E++++ L+ K E +EL
Sbjct: 1230 EKE---NADLAGELRV------LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 904 SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 963
KLQ + G L EAEG+ ++L V L+D Q + ++ + ++ N++ +RQ
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 964 EFEDRLAASE--EETRQAKAELATLQARQQLELEEVHRRVKTALA----------RKEEA 1011
E+R + + +E +AK L + ++L + ++++ + R ++
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 1012 VSSLRTQHEAAVKRADHLEE 1031
+ +L Q+E D LE+
Sbjct: 1401 IENLTQQYEEKAAAYDKLEK 1420
Score = 98.6 bits (244), Expect = 3e-20
Identities = 204/873 (23%), Positives = 358/873 (41%), Gaps = 174/873 (19%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG---AGAARLEHLLQAKREEQRQ 306
L + K E +A F Q+ I ++ A ARL+ + K ++
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 307 -RSGEGTLLDLHQQ---KEAARRKAREEKAR-----QARRAAIQEL-------QQKRALR 350
R EG + DL + + AAR KA ++K +A + +++ Q+ RA R
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 351 AQKASTAERGPPENPR--ETRVPGMRQP--------AQELSPTPGGTAH-----QALKAN 395
Q+ + ++ E R E +V MRQ ++L A+ Q L+
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 396 NT--GGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKS 453
N G L G + +Q E + + + AQ E+ + ++
Sbjct: 1233 NADLAGELRVLG-------------QAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERA 1274
Query: 454 RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPE 513
R L + +H LQ E + + G+ A L D +L E
Sbjct: 1275 RAELNDKVHKLQ---NEVESVTGMLNEAEGK---------AIKLAKDVASLSSQLQDTQE 1322
Query: 514 PPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL 573
++ T + + + + L+E S QDQLD + E L +ST ++L
Sbjct: 1323 LLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEA--------KQNLERHISTLNIQL 1373
Query: 574 -----KLE--------VEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR--------- 611
KL+ +EE K+ L QQ + A + EK +R
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 612 -QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKC----EAVVAELKQEDQRCTERVAQA 666
L QR+ + +++ DQL+ ++K +S K + AE ++++ T+ ++ A
Sbjct: 1434 VDLDNQRQ-LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1489
Query: 667 QAQHE-LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRR 725
+A E LE K+ E + KA E +S K K V LE + L + ++ +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMKTQ 1547
Query: 726 LKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQ 785
L+ L + LQ+ E A R + L+ Q ER+ +A +Q E+ RQ QR +L E +
Sbjct: 1548 LEELEDE--LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETE 1604
Query: 786 LEESSS--ALTRALRAEFE--------------KGREEQERRHQMELNTLKQQLELERQA 829
LE+ AL A + + E KGREE + +L L+ Q++ ++
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK----QLRKLQAQMKDFQRE 1660
Query: 830 WEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKR 889
E R ++E + +E E + K +E + +L+ D+A A E + K A+ +
Sbjct: 1661 LEDARASRDEIFATAKENEKKA-------KSLEADLMQLQEDLAAA-ERARKQADLEKEE 1712
Query: 890 LRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 946
L ++ + LS L+ +R+L+ R ++L+ +L E +G + VR +A + A+ +
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQL 1769
Query: 947 NEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALA 1006
+ +L++ERS A + E+ ARQQLE + ++ +++ L
Sbjct: 1770 SNELATERST--------------AQKNES-----------ARQQLERQ--NKELRSKLH 1802
Query: 1007 RKEEAVSSLRTQHEAAVK-RADHLEELLEQHRR 1038
E AV S AA++ + LEE +EQ R
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Score = 96.3 bits (238), Expect = 1e-19
Identities = 145/594 (24%), Positives = 256/594 (43%), Gaps = 94/594 (15%)
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQL-LEKEPDVLPRPRT 479
Q+ E+ TQ + AA D LE K++ L++ L L + L+ + ++
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 480 HHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKS 539
R +EE + SS AD ++ A E L L+ + +E+E++
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 540 GQDQLDSQQEGWVP---EAGPGPLELGS----------EVSTSVMRLKLEVEEKKQAMLL 586
+ L ++ E V + G EL E+ T + L+ E++ + A L
Sbjct: 1506 NK-MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 587 LQ---RALAQQ--RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVL 641
L+ +AL Q RDL AR + EK RQLQRQ YE + ED++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHEYETEL-----------EDER-- 1609
Query: 642 SEKCEAVVAELKQE-DQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTKK 699
++ A A+ K E D + E A + + E IK+L++L + + +RE + ++
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR- 1668
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL--LQSDERASQRCLRQAEELREQLE 757
++ A K+ ++ KSL EA+L LQ D A++R +QA+ +E+L
Sbjct: 1669 -------------DEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 758 RE--KEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQME 815
E G+ + ++R A + +L ++LEE + + ++ R+ +
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM---------EAMSDRVRKATQQ 1765
Query: 816 LNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK-EIELVIHRLEADMAL 874
L +L ER + + +++ N+E + +G K + + I LEA +A
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 875 AKEE-----SEKAAESRIKRLRDKYEAELSELEQSERKLQE-----------RCSELKGQ 918
+E+ EK A ++ + +DK E+ + ERK+ E R +LK Q
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 919 LGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAAS 972
L EAE E+ R+ R+ +R L++A NE + E + L +R+ E S
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPS 1939
Score = 83.6 bits (205), Expect = 9e-16
Identities = 76/277 (27%), Positives = 139/277 (50%), Gaps = 18/277 (6%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
RQ EE++ +E E +ER++ + + ELE+ QL E + L L+AE E E
Sbjct: 849 RQEEEMQA---KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+E R + L KQ+LE EA R +EE +R Q+L+ E +K + ++L
Sbjct: 906 AEEMR--VRLAAKKQELEEILHEMEA-RLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 958
Query: 867 RLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQERCSELKGQLGEA 922
E + A K + EK AE++IK+L D+ + + ++L + + L+ER S+L L E
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 923 EGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAE 982
E + L L + E + + + ++ R L + ++++ E + E+ +A+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 983 LATLQ---ARQQLELEEVHRRVKTALARKEEAVSSLR 1016
+A L+ A+++ EL+ R+ +A+K A+ +R
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Score = 75.1 bits (183), Expect = 3e-13
Identities = 104/425 (24%), Positives = 190/425 (44%), Gaps = 87/425 (20%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
R A A+ Q +L +K ++ +A K R +W TK ++P +Q + R +
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK---------VKPLLQ--VTRQE 851
Query: 721 QEVRRLKSLHEAELLQSDERA--SQRCLRQAEELREQLEREKEALGQQERERARQRQRAE 778
+E++ E EL ++ ER ++ L++ E+ QL EK L QE+ +A AE
Sbjct: 852 EEMQA----KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL--QEQLQAETELYAE 905
Query: 779 LEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKE 838
EE+R +L L L E E EE+E R Q QL+ ER +K
Sbjct: 906 AEEMRVRLAAKKQELEEILH-EMEARLEEEEDRGQ--------QLQAER--------KKM 948
Query: 839 EAWLLNREQELREEIRKGRDKEIELV-----IHRLEADMALAKEESEKAAESR------- 886
+L+ E++L EE + ++E V I +LE ++ + +++ K ++ R
Sbjct: 949 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 887 ----------------IKRLRDKYEAELS--------------ELEQSERKLQERCSELK 916
+ +L++K+E+ +S ELE+ +RKL+ S+
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 917 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 976
Q+ + + + L+ + +KE L+ A A + ++++N + IR E E ++ +E+
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDL 1127
Query: 977 RQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADH---LEELL 1033
+A + +Q+ +L E +KT L E+ + S TQ E KR L++ L
Sbjct: 1128 DSERAARNKAE-KQKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 1034 EQHRR 1038
++ R
Sbjct: 1184 DEETR 1188
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 110 bits (275), Expect = 7e-24
Identities = 135/560 (24%), Positives = 263/560 (46%), Gaps = 69/560 (12%)
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGS-----EVSTSVMRLKLEVEE 579
+L+ S L E + Q+QL ++ E + EA + L + E M +LE EE
Sbjct: 884 ELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 580 KKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----LAFIDQ-- 633
+ L +R Q+ L E E+A ++LQ ++ EA I++ L DQ
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 634 -LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW 692
L +++K+L E+ + L +E+++ + + + + +HE I +L+ + EK+R+E
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKA-KNLTKLKNKHESMISELEVRLKKEEKSRQEL- 1060
Query: 693 ISEKTKKIKEVTVRGLEPEIQKL---IARHKQEVRRLKSLHEAELLQSDERASQRC---- 745
EK K+ E +I L IA K ++ + + +A L + D+ +Q+
Sbjct: 1061 --EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 746 -LRQAE----ELREQLEREKEALGQQERERARQRQRAELEELRQQLEES--SSALTRALR 798
+R+ E +L+E L+ E+ A + E+++ + ELE L+ +LE++ S+A + LR
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE--ELEALKTELEDTLDSTATQQELR 1176
Query: 799 AEFE-------KGREEQERRHQMELNTLKQQ--LELERQAWEAGRTRKEEAWLLNREQEL 849
A+ E K +E+ R H+ ++ ++Q+ +E + + ++ +A L +Q L
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 850 REEIRKGRDKEIELVIHRLEADMALAKEESE---KAAESRIKRLRDKY---EAELSELEQ 903
+E D EL + + AK+E E K E++++ L+ K E +EL
Sbjct: 1237 EKE---NADLAGELRV------LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 904 SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 963
KLQ + G L EAEG+ ++L V L+D Q + ++ + ++ N++ +RQ
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 964 EFEDRLAASE--EETRQAKAELATLQARQQLELEEVHRRVKTALA----------RKEEA 1011
E+R + + +E +AK L + ++L + ++++ + R ++
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 1012 VSSLRTQHEAAVKRADHLEE 1031
+ +L Q+E D LE+
Sbjct: 1408 IENLTQQYEEKAAAYDKLEK 1427
Score = 98.6 bits (244), Expect = 3e-20
Identities = 204/873 (23%), Positives = 358/873 (41%), Gaps = 174/873 (19%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG---AGAARLEHLLQAKREEQRQ 306
L + K E +A F Q+ I ++ A ARL+ + K ++
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 307 -RSGEGTLLDLHQQ---KEAARRKAREEKAR-----QARRAAIQEL-------QQKRALR 350
R EG + DL + + AAR KA ++K +A + +++ Q+ RA R
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 351 AQKASTAERGPPENPR--ETRVPGMRQP--------AQELSPTPGGTAH-----QALKAN 395
Q+ + ++ E R E +V MRQ ++L A+ Q L+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 396 NT--GGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKS 453
N G L G + +Q E + + + AQ E+ + ++
Sbjct: 1240 NADLAGELRVLG-------------QAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERA 1281
Query: 454 RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPE 513
R L + +H LQ E + + G+ A L D +L E
Sbjct: 1282 RAELNDKVHKLQ---NEVESVTGMLNEAEGK---------AIKLAKDVASLSSQLQDTQE 1329
Query: 514 PPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL 573
++ T + + + + L+E S QDQLD + E L +ST ++L
Sbjct: 1330 LLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEA--------KQNLERHISTLNIQL 1380
Query: 574 -----KLE--------VEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR--------- 611
KL+ +EE K+ L QQ + A + EK +R
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 612 -QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKC----EAVVAELKQEDQRCTERVAQA 666
L QR+ + +++ DQL+ ++K +S K + AE ++++ T+ ++ A
Sbjct: 1441 VDLDNQRQ-LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1496
Query: 667 QAQHE-LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRR 725
+A E LE K+ E + KA E +S K K V LE + L + ++ +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMKTQ 1554
Query: 726 LKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQ 785
L+ L + LQ+ E A R + L+ Q ER+ +A +Q E+ RQ QR +L E +
Sbjct: 1555 LEELEDE--LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETE 1611
Query: 786 LEESSS--ALTRALRAEFE--------------KGREEQERRHQMELNTLKQQLELERQA 829
LE+ AL A + + E KGREE + +L L+ Q++ ++
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK----QLRKLQAQMKDFQRE 1667
Query: 830 WEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKR 889
E R ++E + +E E + K +E + +L+ D+A A E + K A+ +
Sbjct: 1668 LEDARASRDEIFATAKENEKKA-------KSLEADLMQLQEDLAAA-ERARKQADLEKEE 1719
Query: 890 LRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 946
L ++ + LS L+ +R+L+ R ++L+ +L E +G + VR +A + A+ +
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQL 1776
Query: 947 NEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALA 1006
+ +L++ERS A + E+ ARQQLE + ++ +++ L
Sbjct: 1777 SNELATERST--------------AQKNES-----------ARQQLERQ--NKELRSKLH 1809
Query: 1007 RKEEAVSSLRTQHEAAVK-RADHLEELLEQHRR 1038
E AV S AA++ + LEE +EQ R
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Score = 96.3 bits (238), Expect = 1e-19
Identities = 145/594 (24%), Positives = 256/594 (43%), Gaps = 94/594 (15%)
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQL-LEKEPDVLPRPRT 479
Q+ E+ TQ + AA D LE K++ L++ L L + L+ + ++
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 480 HHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKS 539
R +EE + SS AD ++ A E L L+ + +E+E++
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 540 GQDQLDSQQEGWVP---EAGPGPLELGS----------EVSTSVMRLKLEVEEKKQAMLL 586
+ L ++ E V + G EL E+ T + L+ E++ + A L
Sbjct: 1513 NK-MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 587 LQ---RALAQQ--RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVL 641
L+ +AL Q RDL AR + EK RQLQRQ YE + ED++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHEYETEL-----------EDER-- 1616
Query: 642 SEKCEAVVAELKQE-DQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTKK 699
++ A A+ K E D + E A + + E IK+L++L + + +RE + ++
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR- 1675
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL--LQSDERASQRCLRQAEELREQLE 757
++ A K+ ++ KSL EA+L LQ D A++R +QA+ +E+L
Sbjct: 1676 -------------DEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 758 RE--KEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQME 815
E G+ + ++R A + +L ++LEE + + ++ R+ +
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM---------EAMSDRVRKATQQ 1772
Query: 816 LNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK-EIELVIHRLEADMAL 874
L +L ER + + +++ N+E + +G K + + I LEA +A
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 875 AKEE-----SEKAAESRIKRLRDKYEAELSELEQSERKLQE-----------RCSELKGQ 918
+E+ EK A ++ + +DK E+ + ERK+ E R +LK Q
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 919 LGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAAS 972
L EAE E+ R+ R+ +R L++A NE + E + L +R+ E S
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPS 1946
Score = 83.6 bits (205), Expect = 9e-16
Identities = 76/277 (27%), Positives = 139/277 (50%), Gaps = 18/277 (6%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
RQ EE++ +E E +ER++ + + ELE+ QL E + L L+AE E E
Sbjct: 856 RQEEEMQA---KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+E R + L KQ+LE EA R +EE +R Q+L+ E +K + ++L
Sbjct: 913 AEEMR--VRLAAKKQELEEILHEMEA-RLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 965
Query: 867 RLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQERCSELKGQLGEA 922
E + A K + EK AE++IK+L D+ + + ++L + + L+ER S+L L E
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 923 EGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAE 982
E + L L + E + + + ++ R L + ++++ E + E+ +A+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 983 LATLQ---ARQQLELEEVHRRVKTALARKEEAVSSLR 1016
+A L+ A+++ EL+ R+ +A+K A+ +R
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Score = 75.1 bits (183), Expect = 3e-13
Identities = 104/425 (24%), Positives = 190/425 (44%), Gaps = 87/425 (20%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
R A A+ Q +L +K ++ +A K R +W TK ++P +Q + R +
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK---------VKPLLQ--VTRQE 858
Query: 721 QEVRRLKSLHEAELLQSDERA--SQRCLRQAEELREQLEREKEALGQQERERARQRQRAE 778
+E++ E EL ++ ER ++ L++ E+ QL EK L QE+ +A AE
Sbjct: 859 EEMQA----KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL--QEQLQAETELYAE 912
Query: 779 LEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKE 838
EE+R +L L L E E EE+E R Q QL+ ER +K
Sbjct: 913 AEEMRVRLAAKKQELEEILH-EMEARLEEEEDRGQ--------QLQAER--------KKM 955
Query: 839 EAWLLNREQELREEIRKGRDKEIELV-----IHRLEADMALAKEESEKAAESR------- 886
+L+ E++L EE + ++E V I +LE ++ + +++ K ++ R
Sbjct: 956 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 887 ----------------IKRLRDKYEAELS--------------ELEQSERKLQERCSELK 916
+ +L++K+E+ +S ELE+ +RKL+ S+
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 917 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 976
Q+ + + + L+ + +KE L+ A A + ++++N + IR E E ++ +E+
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDL 1134
Query: 977 RQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADH---LEELL 1033
+A + +Q+ +L E +KT L E+ + S TQ E KR L++ L
Sbjct: 1135 DSERAARNKAE-KQKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 1034 EQHRR 1038
++ R
Sbjct: 1191 DEETR 1195
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 110 bits (275), Expect = 7e-24
Identities = 135/560 (24%), Positives = 263/560 (46%), Gaps = 69/560 (12%)
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGS-----EVSTSVMRLKLEVEE 579
+L+ S L E + Q+QL ++ E + EA + L + E M +LE EE
Sbjct: 884 ELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 580 KKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----LAFIDQ-- 633
+ L +R Q+ L E E+A ++LQ ++ EA I++ L DQ
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 634 -LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW 692
L +++K+L E+ + L +E+++ + + + + +HE I +L+ + EK+R+E
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKA-KNLTKLKNKHESMISELEVRLKKEEKSRQEL- 1060
Query: 693 ISEKTKKIKEVTVRGLEPEIQKL---IARHKQEVRRLKSLHEAELLQSDERASQRC---- 745
EK K+ E +I L IA K ++ + + +A L + D+ +Q+
Sbjct: 1061 --EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 746 -LRQAE----ELREQLEREKEALGQQERERARQRQRAELEELRQQLEES--SSALTRALR 798
+R+ E +L+E L+ E+ A + E+++ + ELE L+ +LE++ S+A + LR
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE--ELEALKTELEDTLDSTATQQELR 1176
Query: 799 AEFE-------KGREEQERRHQMELNTLKQQ--LELERQAWEAGRTRKEEAWLLNREQEL 849
A+ E K +E+ R H+ ++ ++Q+ +E + + ++ +A L +Q L
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 850 REEIRKGRDKEIELVIHRLEADMALAKEESE---KAAESRIKRLRDKY---EAELSELEQ 903
+E D EL + + AK+E E K E++++ L+ K E +EL
Sbjct: 1237 EKE---NADLAGELRV------LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 904 SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 963
KLQ + G L EAEG+ ++L V L+D Q + ++ + ++ N++ +RQ
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 964 EFEDRLAASE--EETRQAKAELATLQARQQLELEEVHRRVKTALA----------RKEEA 1011
E+R + + +E +AK L + ++L + ++++ + R ++
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 1012 VSSLRTQHEAAVKRADHLEE 1031
+ +L Q+E D LE+
Sbjct: 1408 IENLTQQYEEKAAAYDKLEK 1427
Score = 98.6 bits (244), Expect = 3e-20
Identities = 204/873 (23%), Positives = 358/873 (41%), Gaps = 174/873 (19%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG---AGAARLEHLLQAKREEQRQ 306
L + K E +A F Q+ I ++ A ARL+ + K ++
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 307 -RSGEGTLLDLHQQ---KEAARRKAREEKAR-----QARRAAIQEL-------QQKRALR 350
R EG + DL + + AAR KA ++K +A + +++ Q+ RA R
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 351 AQKASTAERGPPENPR--ETRVPGMRQP--------AQELSPTPGGTAH-----QALKAN 395
Q+ + ++ E R E +V MRQ ++L A+ Q L+
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 396 NT--GGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKS 453
N G L G + +Q E + + + AQ E+ + ++
Sbjct: 1240 NADLAGELRVLG-------------QAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERA 1281
Query: 454 RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPE 513
R L + +H LQ E + + G+ A L D +L E
Sbjct: 1282 RAELNDKVHKLQ---NEVESVTGMLNEAEGK---------AIKLAKDVASLSSQLQDTQE 1329
Query: 514 PPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL 573
++ T + + + + L+E S QDQLD + E L +ST ++L
Sbjct: 1330 LLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEA--------KQNLERHISTLNIQL 1380
Query: 574 -----KLE--------VEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR--------- 611
KL+ +EE K+ L QQ + A + EK +R
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 612 -QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKC----EAVVAELKQEDQRCTERVAQA 666
L QR+ + +++ DQL+ ++K +S K + AE ++++ T+ ++ A
Sbjct: 1441 VDLDNQRQ-LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1496
Query: 667 QAQHE-LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRR 725
+A E LE K+ E + KA E +S K K V LE + L + ++ +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMKTQ 1554
Query: 726 LKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQ 785
L+ L + LQ+ E A R + L+ Q ER+ +A +Q E+ RQ QR +L E +
Sbjct: 1555 LEELEDE--LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETE 1611
Query: 786 LEESSS--ALTRALRAEFE--------------KGREEQERRHQMELNTLKQQLELERQA 829
LE+ AL A + + E KGREE + +L L+ Q++ ++
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK----QLRKLQAQMKDFQRE 1667
Query: 830 WEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKR 889
E R ++E + +E E + K +E + +L+ D+A A E + K A+ +
Sbjct: 1668 LEDARASRDEIFATAKENEKKA-------KSLEADLMQLQEDLAAA-ERARKQADLEKEE 1719
Query: 890 LRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 946
L ++ + LS L+ +R+L+ R ++L+ +L E +G + VR +A + A+ +
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQL 1776
Query: 947 NEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALA 1006
+ +L++ERS A + E+ ARQQLE + ++ +++ L
Sbjct: 1777 SNELATERST--------------AQKNES-----------ARQQLERQ--NKELRSKLH 1809
Query: 1007 RKEEAVSSLRTQHEAAVK-RADHLEELLEQHRR 1038
E AV S AA++ + LEE +EQ R
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Score = 95.5 bits (236), Expect = 2e-19
Identities = 143/584 (24%), Positives = 253/584 (43%), Gaps = 94/584 (16%)
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQL-LEKEPDVLPRPRT 479
Q+ E+ TQ + AA D LE K++ L++ L L + L+ + ++
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455
Query: 480 HHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKS 539
R +EE + SS AD ++ A E L L+ + +E+E++
Sbjct: 1456 KQRKFDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERT 1512
Query: 540 GQDQLDSQQEGWVP---EAGPGPLELGS----------EVSTSVMRLKLEVEEKKQAMLL 586
+ L ++ E V + G EL E+ T + L+ E++ + A L
Sbjct: 1513 NK-MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 587 LQ---RALAQQ--RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVL 641
L+ +AL Q RDL AR + EK RQLQRQ YE + ED++
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHEYETEL-----------EDER-- 1616
Query: 642 SEKCEAVVAELKQE-DQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTKK 699
++ A A+ K E D + E A + + E IK+L++L + + +RE + ++
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR- 1675
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL--LQSDERASQRCLRQAEELREQLE 757
++ A K+ ++ KSL EA+L LQ D A++R +QA+ +E+L
Sbjct: 1676 -------------DEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 758 RE--KEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQME 815
E G+ + ++R A + +L ++LEE + + ++ R+ +
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM---------EAMSDRVRKATQQ 1772
Query: 816 LNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK-EIELVIHRLEADMAL 874
L +L ER + + +++ N+E + +G K + + I LEA +A
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 875 AKEE-----SEKAAESRIKRLRDKYEAELSELEQSERKLQE-----------RCSELKGQ 918
+E+ EK A ++ + +DK E+ + ERK+ E R +LK Q
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 919 LGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
L EAE E+ R+ R+ +R L++A NE + E + L +R
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 83.6 bits (205), Expect = 9e-16
Identities = 76/277 (27%), Positives = 139/277 (50%), Gaps = 18/277 (6%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
RQ EE++ +E E +ER++ + + ELE+ QL E + L L+AE E E
Sbjct: 856 RQEEEMQA---KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+E R + L KQ+LE EA R +EE +R Q+L+ E +K + ++L
Sbjct: 913 AEEMR--VRLAAKKQELEEILHEMEA-RLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 965
Query: 867 RLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQERCSELKGQLGEA 922
E + A K + EK AE++IK+L D+ + + ++L + + L+ER S+L L E
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 923 EGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAE 982
E + L L + E + + + ++ R L + ++++ E + E+ +A+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 983 LATLQ---ARQQLELEEVHRRVKTALARKEEAVSSLR 1016
+A L+ A+++ EL+ R+ +A+K A+ +R
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Score = 75.1 bits (183), Expect = 3e-13
Identities = 104/425 (24%), Positives = 190/425 (44%), Gaps = 87/425 (20%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
R A A+ Q +L +K ++ +A K R +W TK ++P +Q + R +
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK---------VKPLLQ--VTRQE 858
Query: 721 QEVRRLKSLHEAELLQSDERA--SQRCLRQAEELREQLEREKEALGQQERERARQRQRAE 778
+E++ E EL ++ ER ++ L++ E+ QL EK L QE+ +A AE
Sbjct: 859 EEMQA----KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL--QEQLQAETELYAE 912
Query: 779 LEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKE 838
EE+R +L L L E E EE+E R Q QL+ ER +K
Sbjct: 913 AEEMRVRLAAKKQELEEILH-EMEARLEEEEDRGQ--------QLQAER--------KKM 955
Query: 839 EAWLLNREQELREEIRKGRDKEIELV-----IHRLEADMALAKEESEKAAESR------- 886
+L+ E++L EE + ++E V I +LE ++ + +++ K ++ R
Sbjct: 956 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 887 ----------------IKRLRDKYEAELS--------------ELEQSERKLQERCSELK 916
+ +L++K+E+ +S ELE+ +RKL+ S+
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 917 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 976
Q+ + + + L+ + +KE L+ A A + ++++N + IR E E ++ +E+
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDL 1134
Query: 977 RQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADH---LEELL 1033
+A + +Q+ +L E +KT L E+ + S TQ E KR L++ L
Sbjct: 1135 DSERAARNKAE-KQKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 1034 EQHRR 1038
++ R
Sbjct: 1191 DEETR 1195
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 110 bits (275), Expect = 7e-24
Identities = 135/560 (24%), Positives = 263/560 (46%), Gaps = 69/560 (12%)
Query: 525 KLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGS-----EVSTSVMRLKLEVEE 579
+L+ S L E + Q+QL ++ E + EA + L + E M +LE EE
Sbjct: 877 ELEQKHSQLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 580 KKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRH----LAFIDQ-- 633
+ L +R Q+ L E E+A ++LQ ++ EA I++ L DQ
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 634 -LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKW 692
L +++K+L E+ + L +E+++ + + + + +HE I +L+ + EK+R+E
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKA-KNLTKLKNKHESMISELEVRLKKEEKSRQEL- 1053
Query: 693 ISEKTKKIKEVTVRGLEPEIQKL---IARHKQEVRRLKSLHEAELLQSDERASQRC---- 745
EK K+ E +I L IA K ++ + + +A L + D+ +Q+
Sbjct: 1054 --EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 746 -LRQAE----ELREQLEREKEALGQQERERARQRQRAELEELRQQLEES--SSALTRALR 798
+R+ E +L+E L+ E+ A + E+++ + ELE L+ +LE++ S+A + LR
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE--ELEALKTELEDTLDSTATQQELR 1169
Query: 799 AEFE-------KGREEQERRHQMELNTLKQQ--LELERQAWEAGRTRKEEAWLLNREQEL 849
A+ E K +E+ R H+ ++ ++Q+ +E + + ++ +A L +Q L
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 850 REEIRKGRDKEIELVIHRLEADMALAKEESE---KAAESRIKRLRDKY---EAELSELEQ 903
+E D EL + + AK+E E K E++++ L+ K E +EL
Sbjct: 1230 EKE---NADLAGELRV------LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 904 SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 963
KLQ + G L EAEG+ ++L V L+D Q + ++ + ++ N++ +RQ
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 964 EFEDRLAASE--EETRQAKAELATLQARQQLELEEVHRRVKTALA----------RKEEA 1011
E+R + + +E +AK L + ++L + ++++ + R ++
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 1012 VSSLRTQHEAAVKRADHLEE 1031
+ +L Q+E D LE+
Sbjct: 1401 IENLTQQYEEKAAAYDKLEK 1420
Score = 98.6 bits (244), Expect = 3e-20
Identities = 204/873 (23%), Positives = 358/873 (41%), Gaps = 174/873 (19%)
Query: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRG---AGAARLEHLLQAKREEQRQ 306
L + K E +A F Q+ I ++ A ARL+ + K ++
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 307 -RSGEGTLLDLHQQ---KEAARRKAREEKAR-----QARRAAIQEL-------QQKRALR 350
R EG + DL + + AAR KA ++K +A + +++ Q+ RA R
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 351 AQKASTAERGPPENPR--ETRVPGMRQP--------AQELSPTPGGTAH-----QALKAN 395
Q+ + ++ E R E +V MRQ ++L A+ Q L+
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 396 NT--GGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKS 453
N G L G + +Q E + + + AQ E+ + ++
Sbjct: 1233 NADLAGELRVLG-------------QAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERA 1274
Query: 454 RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPE 513
R L + +H LQ E + + G+ A L D +L E
Sbjct: 1275 RAELNDKVHKLQ---NEVESVTGMLNEAEGK---------AIKLAKDVASLSSQLQDTQE 1322
Query: 514 PPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRL 573
++ T + + + + L+E S QDQLD + E L +ST ++L
Sbjct: 1323 LLQEETR-QKLNVSTKLRQLEEERNSLQDQLDEEMEA--------KQNLERHISTLNIQL 1373
Query: 574 -----KLE--------VEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR--------- 611
KL+ +EE K+ L QQ + A + EK +R
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 612 -QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKC----EAVVAELKQEDQRCTERVAQA 666
L QR+ + +++ DQL+ ++K +S K + AE ++++ T+ ++ A
Sbjct: 1434 VDLDNQRQ-LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE---TKALSLA 1489
Query: 667 QAQHE-LEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRR 725
+A E LE K+ E + KA E +S K K V LE + L + ++ +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--HELEKSKRALETQMEEMKTQ 1547
Query: 726 LKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQ 785
L+ L + LQ+ E A R + L+ Q ER+ +A +Q E+ RQ QR +L E +
Sbjct: 1548 LEELEDE--LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETE 1604
Query: 786 LEESSS--ALTRALRAEFE--------------KGREEQERRHQMELNTLKQQLELERQA 829
LE+ AL A + + E KGREE + +L L+ Q++ ++
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK----QLRKLQAQMKDFQRE 1660
Query: 830 WEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKR 889
E R ++E + +E E + K +E + +L+ D+A A E + K A+ +
Sbjct: 1661 LEDARASRDEIFATAKENEKKA-------KSLEADLMQLQEDLAAA-ERARKQADLEKEE 1712
Query: 890 LRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV 946
L ++ + LS L+ +R+L+ R ++L+ +L E +G + VR +A + A+ +
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR---KATQQAEQL 1769
Query: 947 NEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALA 1006
+ +L++ERS A + E+ ARQQLE + ++ +++ L
Sbjct: 1770 SNELATERST--------------AQKNES-----------ARQQLERQ--NKELRSKLH 1802
Query: 1007 RKEEAVSSLRTQHEAAVK-RADHLEELLEQHRR 1038
E AV S AA++ + LEE +EQ R
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Score = 95.5 bits (236), Expect = 2e-19
Identities = 143/584 (24%), Positives = 253/584 (43%), Gaps = 94/584 (16%)
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQL-LEKEPDVLPRPRT 479
Q+ E+ TQ + AA D LE K++ L++ L L + L+ + ++
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLE---------KTKNRLQQELDDLVVDLDNQRQLVSNLEK 1448
Query: 480 HHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKS 539
R +EE + SS AD ++ A E L L+ + +E+E++
Sbjct: 1449 KQRKFDQLLAEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERT 1505
Query: 540 GQDQLDSQQEGWVP---EAGPGPLELGS----------EVSTSVMRLKLEVEEKKQAMLL 586
+ L ++ E V + G EL E+ T + L+ E++ + A L
Sbjct: 1506 NK-MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 587 LQ---RALAQQ--RDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVL 641
L+ +AL Q RDL AR + EK RQLQRQ YE + ED++
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKR--RQLQRQLHEYETEL-----------EDER-- 1609
Query: 642 SEKCEAVVAELKQE-DQRCTERVAQAQAQ-HELEIKKLKELMSATEKARREKWISEKTKK 699
++ A A+ K E D + E A + + E IK+L++L + + +RE + ++
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR- 1668
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAEL--LQSDERASQRCLRQAEELREQLE 757
++ A K+ ++ KSL EA+L LQ D A++R +QA+ +E+L
Sbjct: 1669 -------------DEIFATAKENEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 758 RE--KEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQME 815
E G+ + ++R A + +L ++LEE + + ++ R+ +
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM---------EAMSDRVRKATQQ 1765
Query: 816 LNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDK-EIELVIHRLEADMAL 874
L +L ER + + +++ N+E + +G K + + I LEA +A
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 875 AKEE-----SEKAAESRIKRLRDKYEAELSELEQSERKLQE-----------RCSELKGQ 918
+E+ EK A ++ + +DK E+ + ERK+ E R +LK Q
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 919 LGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
L EAE E+ R+ R+ +R L++A NE + E + L +R
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 83.6 bits (205), Expect = 9e-16
Identities = 76/277 (27%), Positives = 139/277 (50%), Gaps = 18/277 (6%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
RQ EE++ +E E +ER++ + + ELE+ QL E + L L+AE E E
Sbjct: 849 RQEEEMQA---KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+E R + L KQ+LE EA R +EE +R Q+L+ E +K + ++L
Sbjct: 906 AEEMR--VRLAAKKQELEEILHEMEA-RLEEEE----DRGQQLQAERKKMAQQMLDLEEQ 958
Query: 867 RLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQERCSELKGQLGEA 922
E + A K + EK AE++IK+L D+ + + ++L + + L+ER S+L L E
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 923 EGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAE 982
E + L L + E + + + ++ R L + ++++ E + E+ +A+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 983 LATLQ---ARQQLELEEVHRRVKTALARKEEAVSSLR 1016
+A L+ A+++ EL+ R+ +A+K A+ +R
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Score = 75.1 bits (183), Expect = 3e-13
Identities = 104/425 (24%), Positives = 190/425 (44%), Gaps = 87/425 (20%)
Query: 662 RVAQAQAQHELE-IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHK 720
R A A+ Q +L +K ++ +A K R +W TK ++P +Q + R +
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK---------VKPLLQ--VTRQE 851
Query: 721 QEVRRLKSLHEAELLQSDERA--SQRCLRQAEELREQLEREKEALGQQERERARQRQRAE 778
+E++ E EL ++ ER ++ L++ E+ QL EK L QE+ +A AE
Sbjct: 852 EEMQA----KEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL--QEQLQAETELYAE 905
Query: 779 LEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKE 838
EE+R +L L L E E EE+E R Q QL+ ER +K
Sbjct: 906 AEEMRVRLAAKKQELEEILH-EMEARLEEEEDRGQ--------QLQAER--------KKM 948
Query: 839 EAWLLNREQELREEIRKGRDKEIELV-----IHRLEADMALAKEESEKAAESR------- 886
+L+ E++L EE + ++E V I +LE ++ + +++ K ++ R
Sbjct: 949 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 887 ----------------IKRLRDKYEAELS--------------ELEQSERKLQERCSELK 916
+ +L++K+E+ +S ELE+ +RKL+ S+
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 917 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 976
Q+ + + + L+ + +KE L+ A A + ++++N + IR E E ++ +E+
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDL 1127
Query: 977 RQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADH---LEELL 1033
+A + +Q+ +L E +KT L E+ + S TQ E KR L++ L
Sbjct: 1128 DSERAARNKAE-KQKRDLGEELEALKTEL---EDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 1034 EQHRR 1038
++ R
Sbjct: 1184 DEETR 1188
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 108 bits (271), Expect = 2e-23
Identities = 219/881 (24%), Positives = 346/881 (39%), Gaps = 159/881 (18%)
Query: 241 RNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAK 300
R +G +R E+ EEAE + + +Q R +R A A L
Sbjct: 299 RQEAQALSGQAKRAELYREEAEALRERAGRLP-RLQEELRRCRERLQAAEAYKSQL---- 353
Query: 301 REEQRQRSG--EGTLLDLHQQKEAARRK-AREEKARQARRAAIQELQQKRA----LRAQK 353
EE+R SG E + L +Q EAAR + AR + ++ L + A LR Q
Sbjct: 354 -EEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQV 412
Query: 354 ASTAERG-------------PPENPRETRVPGMRQPAQ-ELSPTPGGTAHQALKANNTGG 399
AE PP +P E + G Q E+ G + N
Sbjct: 413 DQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELR 472
Query: 400 GLPAAGPG--------------DRCLPTSDSSPEPQQPPEDRTQDVL--AQDAAGDNLEM 443
GL G D LP + +P+ + Q ++ A+D L++
Sbjct: 473 GLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDL 532
Query: 444 MAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRP---RTHHRGRYAWASEEDDASSLTAD 500
P+ S LE Q + +P P W+ +E + T +
Sbjct: 533 APPALDSV-----LEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQE 587
Query: 501 NLEKFGKLSAFPEP----PEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWV---- 552
+ EK G+ S+ P P G K+Q+ E E Q + E W
Sbjct: 588 SPEKAGRRSSLQSPASVAPPQGP---GTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
Query: 553 -PEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR 611
PE PGP E S ++LE +E L L A+ R+ +R++ T + +
Sbjct: 645 GPEHKPGPSEPSS--------VQLEEQEGPNQGLDLATGQAEAREHD-QRLEGTVRDPAW 695
Query: 612 QLQRQREHYEATIQ------------RHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRC 659
Q +Q+ +Q +A + L E+ L K EA+ EL+ + ++
Sbjct: 696 QKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKL 755
Query: 660 TERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIA-- 717
+ +A + + + A +A + W + ++ E + LE Q+ A
Sbjct: 756 EAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALV 815
Query: 718 -----------RHKQEVRRLKSLHEA--ELLQSDERASQRCLRQAEELREQLEREKEALG 764
+ ++E RL++ EA E +Q E ++ L +AE R REKEAL
Sbjct: 816 EALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERER----REKEAL- 870
Query: 765 QQERERARQRQR---AELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQ 821
Q E E+A R + A LE L+++LE+++ R EF + +E Q +R+Q L+Q
Sbjct: 871 QAELEKAVVRGKELGARLEHLQRELEQAALE-----RQEFLREKESQHQRYQ----GLEQ 921
Query: 822 QLELERQAWEAGRTRKEEAW--LLNREQELREEIRKGRDKEIELVIHRLEADMALAKEES 879
+LE E QA T KEEA L R +L EE+ + R L
Sbjct: 922 RLEAELQA---AATSKEEALMELKTRALQLEEELFQLRQGPAGL--------------GP 964
Query: 880 EKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
+K AE ++ ++ L E+E+S L + L+GQL EG+ LQG ++
Sbjct: 965 KKRAEPQLVETQN---VRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQ 1021
Query: 940 LEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAE----------------- 982
+ AQ + +L +E+S L ++ QE +L EEE R A+
Sbjct: 1022 SQRAQEHSSRLQAEKSVL-EIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKA 1080
Query: 983 LATLQARQQLELEEV---HRRVKTALARKEEAVSSLRTQHE 1020
LA LQ RQ+ ELE + HR +K + E A L+ +HE
Sbjct: 1081 LAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHE 1121
Score = 72.4 bits (176), Expect = 2e-12
Identities = 118/503 (23%), Positives = 220/503 (43%), Gaps = 57/503 (11%)
Query: 579 EKKQAMLLLQRALAQQRDLTARRVKETE-KALSRQLQRQREHYEATIQRHLAFIDQLIED 637
E++ + L Q A++R +V E+E + + +R+R EA A +++ +
Sbjct: 829 EREGSRLRAQSEAAEER----MQVLESEGRQHLEEAERERREKEAL----QAELEKAVVR 880
Query: 638 KKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKT 697
K L + E + EL+Q E + + ++QH+ + L++ + A +A + K
Sbjct: 881 GKELGARLEHLQRELEQAALERQEFLREKESQHQ-RYQGLEQRLEAELQAAA----TSKE 935
Query: 698 KKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSD-------ERASQRCLRQAE 750
+ + E+ R L+ E + R K E +L+++ ER++ + +
Sbjct: 936 EALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKA 995
Query: 751 ELREQLEREKEALGQQE---RERARQRQRAELEELRQQLEESSSALT-RALRAEFEKGRE 806
L+ QL+ + LG + +E Q QRA+ R Q E+S + + L + E E
Sbjct: 996 ALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEE 1055
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRT-RKEEA---WLLNREQELREEIR--KGRDKE 860
E Q + T QQ L R + R++EA LL R ++L+ +R + +E
Sbjct: 1056 EVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRE 1115
Query: 861 IELVIHRLEADMALAKEESEKAAESRIKRLRDKY-----EAELSELEQSERKLQERCSEL 915
++ +L+A A + + R + ++D + E EL L+ + Q +EL
Sbjct: 1116 LQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAEL 1175
Query: 916 KGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNL-AQVIRQEFEDRL----- 969
+ GE +GE L+G + + E + ++QL L R + L
Sbjct: 1176 SRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLR 1235
Query: 970 AASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKE----EAVSSLRTQHEAAVKR 1025
+A EEE RQ AE+ L +R+ EL E + L R++ + +++LR + + V
Sbjct: 1236 SAQEEENRQLLAEVQAL-SRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLV-- 1292
Query: 1026 ADHLEELLEQHR----RPTPSTK 1044
E++++Q+R P P TK
Sbjct: 1293 ----EKIMDQYRVLEPVPLPRTK 1311
Score = 47.8 bits (112), Expect = 6e-05
Identities = 51/202 (25%), Positives = 81/202 (40%), Gaps = 28/202 (13%)
Query: 855 KGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSE 914
+G + L + +A + ++E E+ AE + +AE+ LE R+L++
Sbjct: 250 EGPSHHLALQLANAKAQLRRLRQELEEKAELLLDS-----QAEVQGLEAEIRRLRQEAQA 304
Query: 915 LKGQLGEAE-------------GENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVI 961
L GQ AE G RLQ +R+ L+ A+A QL ER V+
Sbjct: 305 LSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEER-----VL 359
Query: 962 RQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEA 1021
E A EE+ A+ A L Q+ L ++T L + SLR Q +
Sbjct: 360 SGVLEASKALLEEQLEAARERCARLHETQRENL-----LLRTRLGEAHAELDSLRHQVDQ 414
Query: 1022 AVKRADHLEELLEQHRRPTPST 1043
+ LE L++ P P +
Sbjct: 415 LAEENVELELELQRSLEPPPGS 436
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/242 (25%), Positives = 96/242 (39%), Gaps = 26/242 (10%)
Query: 748 QAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREE 807
Q LR++LE + E L + E Q AE+ LR +E+ + +A RAE + E
Sbjct: 266 QLRRLRQELEEKAELLLDSQAEV--QGLEAEIRRLR---QEAQALSGQAKRAELYREEAE 320
Query: 808 QERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHR 867
R L L+++L R+ +A K +L EE ++
Sbjct: 321 ALRERAGRLPRLQEELRRCRERLQAAEAYK---------SQLEEE---------RVLSGV 362
Query: 868 LEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENL 927
LEA AL +E+ E AA R RL + L L + L+ Q+ + EN+
Sbjct: 363 LEASKALLEEQLE-AARERCARLHETQRENLL-LRTRLGEAHAELDSLRHQVDQLAEENV 420
Query: 928 RLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQ 987
L+ L Q+ L+ +L +R+ RL E E R+ + L LQ
Sbjct: 421 ELE-LELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQ 479
Query: 988 AR 989
+
Sbjct: 480 GQ 481
Score = 44.7 bits (104), Expect = 5e-04
Identities = 79/303 (26%), Positives = 131/303 (43%), Gaps = 45/303 (14%)
Query: 555 AGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVK----ETEKALS 610
+GP P EL E+E ++++ LA++RDL A+R+ E E
Sbjct: 190 SGPDPGELAPA----------ELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCL 239
Query: 611 RQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQ- 669
R R E HLA QL K A + L+QE + E + +QA+
Sbjct: 240 RPEAPSRAPAEGP-SHHLAL--QLANAK--------AQLRRLRQELEEKAELLLDSQAEV 288
Query: 670 --HELEIKKLK-ELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRL 726
E EI++L+ E + + +A+R + E+ + ++E G P +Q+ + R ++ RL
Sbjct: 289 QGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERA--GRLPRLQEELRRCRE---RL 343
Query: 727 KSLHEAELLQSDERASQRCLRQAEE-LREQLEREKE---ALGQQERERARQRQR-----A 777
++ + +ER L ++ L EQLE +E L + +RE R R A
Sbjct: 344 QAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHA 403
Query: 778 ELEELRQQLEESSSALTRALRAEFEKGREEQE-RRHQMELNTLKQQLELERQAWEAGRTR 836
EL+ LR Q+++ + L E ++ E + L L+ E + EAGR R
Sbjct: 404 ELDSLRHQVDQLAEENVE-LELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLR 462
Query: 837 KEE 839
E
Sbjct: 463 TLE 465
Score = 41.6 bits (96), Expect = 0.004
Identities = 69/275 (25%), Positives = 120/275 (43%), Gaps = 46/275 (16%)
Query: 553 PEAGPG---PLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKAL 609
P GP L+L + + RL+ E+EEK + +LL +A Q + RR+++ +AL
Sbjct: 248 PAEGPSHHLALQLAN-AKAQLRRLRQELEEKAE-LLLDSQAEVQGLEAEIRRLRQEAQAL 305
Query: 610 SRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQ 669
S Q +R A + R E+ + L E+ + L++E +RC ER+ A+A
Sbjct: 306 SGQAKR------AELYR---------EEAEALRERA-GRLPRLQEELRRCRERLQAAEA- 348
Query: 670 HELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
++ ++++ + L E ++ + E+ + +E R E + + L+ R RL
Sbjct: 349 YKSQLEEERVLSGVLEASK--ALLEEQLEAARERCARLHETQRENLLLR-----TRLGEA 401
Query: 730 HEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEES 789
H AEL + LR Q+++ E + E E R + L +
Sbjct: 402 H-AEL---------------DSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGA 445
Query: 790 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLE 824
+ +L +R E E GR R EL L Q L+
Sbjct: 446 APSLQDEVR-EAEAGRLRTLERENRELRGLLQVLQ 479
Score = 41.6 bits (96), Expect = 0.004
Identities = 43/157 (27%), Positives = 65/157 (41%), Gaps = 27/157 (17%)
Query: 880 EKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERA 939
++A + +LR K EA ELE RKL+ + +E RL + Q RA
Sbjct: 727 QEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA-----------RLSKELAQARRA 775
Query: 940 LEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHR 999
+A E + E++ L + + ++ +AS+E +A A + R+Q E E
Sbjct: 776 EAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREG--- 832
Query: 1000 RVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQH 1036
S LR Q EAA +R LE QH
Sbjct: 833 -------------SRLRAQSEAAEERMQVLESEGRQH 856
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 103 bits (256), Expect = 1e-21
Identities = 160/695 (23%), Positives = 281/695 (40%), Gaps = 106/695 (15%)
Query: 415 DSSPEPQQPPEDRTQDVLAQDAAGD----NLEMMAP-----SRGSAKSRGPLEELLHTLQ 465
DSS PP D D A+D G+ N E + R + RG EL+ Q
Sbjct: 108 DSSTASFDPPSD--MDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
Query: 466 LLEKEPD----VLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLL 521
+L++E +L + + R A EE +L++ + A E + +
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQE--EFDASLEEKDQYISV 223
Query: 522 SEAKLQSIMSFLDEMEKSGQ---------DQLDSQQEGWVPEAGP-GPLELGSEVSTSVM 571
LQ+ +S L + ++G QL+ Q E + E P E E TSV
Sbjct: 224 ----LQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
Query: 572 RLKLEVEEKKQAMLLLQRA--LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLA 629
L+ + K+ LL+R Q + ++AL QL + + E H+A
Sbjct: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339
Query: 630 --------------FIDQLIEDK--------KVLSEKCEAVVAELKQEDQRCTERVAQAQ 667
I+QL +DK + + E E E+ Q R + Q +
Sbjct: 340 EKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE 399
Query: 668 AQHEL----------EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEI--QKL 715
E E++K TE+ARR K +E ++IK + E I Q+
Sbjct: 400 ELREQKEKSERAAFEELEKALSTAQKTEEARR-KLKAEMDEQIKTIEKTSEEERISLQQE 458
Query: 716 IARHKQEV------------RRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEAL 763
++R KQEV +L+ LHE EL + ++ +++ + E +EQ+ K AL
Sbjct: 459 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM---KVAL 515
Query: 764 GQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQL 823
+ + E + Q E +E LEE L K R+ Q+ L+ +
Sbjct: 516 EKSQSEYLKISQEKEQQE-SLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 824 ELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAA 883
LE+ E K+ A L E + +KEI +++ + + ++ K + +
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAE-------KNKHNKEITVMVEKHKTELESLKHQQDALW 627
Query: 884 ESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDA 943
+++ L+ +Y+ E+ KL+E+C + K L + + E + + E+ LE
Sbjct: 628 TEKLQVLKQQYQTEM-------EKLREKCEQEKETLLK-DKEIIFQAHIEEMNEKTLEKL 679
Query: 944 QAVNEQLSSERSNLAQVI--RQEFEDRLAASEEETRQAKAELATLQARQ----QLELEEV 997
+L S S L++V+ R + E+ L+ +++T + K EL Q Q +++ +
Sbjct: 680 DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI 739
Query: 998 HRRVKTALARKEEAVSSLRTQHEAAVKRAD-HLEE 1031
+ + ++ R E+A+ Q E +K D HL+E
Sbjct: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
Score = 100 bits (249), Expect = 7e-21
Identities = 123/566 (21%), Positives = 249/566 (43%), Gaps = 66/566 (11%)
Query: 522 SEAKLQSIMSFLDEMEK-----SGQDQLDSQQE-GWVPEAGPGPLELGSEVSTSVMRLKL 575
+E + + + +DE K S ++++ QQE V + ++ SE + ++
Sbjct: 426 TEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH 485
Query: 576 EVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLI 635
E E ++ L ++ ++R+ + EK+ S L+ +E + Q LA + +
Sbjct: 486 EKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ---QESLALEELEL 542
Query: 636 EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISE 695
+ K +L+E E + +L+QE + R+ + ++ E +++ K K +E
Sbjct: 543 QKKAILTES-ENKLRDLQQEAETYRTRILELESSLEKSLQENKN----QSKDLAVHLEAE 597
Query: 696 KTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQ 755
K K KE+TV ++ +HK E+ LK +A + + Q+ + E+LRE+
Sbjct: 598 KNKHNKEITV---------MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 756 LEREKEAL-----------GQQERERARQR---QRAELEEL----------RQQLEESSS 791
E+EKE L ++ E+ ++ ++ ELE L R +LEE S
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 792 AL---TRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAG---RTRKEEAWLLNR 845
L T ++ E E +EQ+ HQ +++++ ++ E+ Q E + + E L R
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 846 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSE 905
++ L+E + E ++ E A AK + ++ +S YE +L++L+Q
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 906 RKLQERCSELKGQLGEAEGEN----LRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVI 961
L+ L Q+ E E + L Q + ++ + N ++ + +L QV
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 962 RQEFEDRLAASEEETRQAKAE----LATLQARQQLELEEVHRRVKTALARKEEAVSSLRT 1017
+ ED +E+T+Q E + ++ Q+ E+E + ++ L+ KE+++ L
Sbjct: 889 ESKLEDG-NKEQEQTKQILVEKENMILQMREGQKKEIEILTQK----LSAKEDSIHILNE 943
Query: 1018 QHEAAVKRADHLEELLEQHRRPTPST 1043
++E K + E ++Q + T
Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQET 969
Score = 98.6 bits (244), Expect = 3e-20
Identities = 112/463 (24%), Positives = 218/463 (47%), Gaps = 57/463 (12%)
Query: 621 EATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKEL 680
+ T + L + Q ++ ++ L ++C+ + K++ CT ++ +A E ++L+EL
Sbjct: 274 DGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ---CTLLTSEKEALQEQLDERLQEL 330
Query: 681 MSATEKARREKWISEKTKKIKEVT-----VRGLEPEIQKLIARHKQEVRRLKSLHEAELL 735
EK + + ++EKTK I ++ + LE + +IA K+++ + E E+
Sbjct: 331 ----EKIK-DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIA 385
Query: 736 QSDERASQRCLRQAEELREQLEREKEALGQ---------QERERARQRQRAELEELRQQL 786
Q R Q Q EELREQ E+ + A + Q+ E AR++ +AE++E + +
Sbjct: 386 QLRSRIKQMTT-QGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTI 444
Query: 787 EESSSALTRALRAEFEKGREE----QERRHQMELNTLKQQLELERQAWEAGRTRKEEAWL 842
E++S +L+ E + ++E ++ + ++ L++ E E E T+K L
Sbjct: 445 EKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK----L 500
Query: 843 LNREQELREEIRKGRDK---EIELVIHRLEADMALAKEESE-------KAAESRIKRLRD 892
RE+E +E+++ +K E + E +LA EE E +E++++ L+
Sbjct: 501 QTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQ 560
Query: 893 K---YEAELSELEQS-ERKLQERCSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQ 944
+ Y + ELE S E+ LQE ++ K E E N + +V + + LE +
Sbjct: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 945 AVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQ---QLELEEVHRRV 1001
+ L +E+ QV++Q+++ + E+ Q K L L+ ++ Q +EE++ +
Sbjct: 621 HQQDALWTEK---LQVLKQQYQTEMEKLREKCEQEKETL--LKDKEIIFQAHIEEMNEKT 675
Query: 1002 KTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRRPTPSTK 1044
L K+ + SL ++ +K LEE L + T K
Sbjct: 676 LEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Score = 90.5 bits (223), Expect = 7e-18
Identities = 122/541 (22%), Positives = 240/541 (44%), Gaps = 76/541 (14%)
Query: 535 EMEKSGQDQLDSQQEG-WVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAML-----LLQ 588
E K+ + L QQ+ W + L + T + +L+ + E++K+ +L + Q
Sbjct: 610 EKHKTELESLKHQQDALWTEKLQV----LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665
Query: 589 RALAQQRDLTARR--VKETE-KALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKC 645
+ + + T + VK+TE ++LS +L E RH +L E+ VL ++
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELS------EVLKARH-----KLEEELSVLKDQT 714
Query: 646 EAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREK------WISEKTKK 699
+ + EL + + E+ Q Q + IK+ + + TEKA +++ + E+ K
Sbjct: 715 DKMKQEL---EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKH 771
Query: 700 IKE--VTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDE-RASQRCLRQAEELREQL 756
+KE V LE +I++ +Q +L + ++ +A + L Q ++ L
Sbjct: 772 LKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831
Query: 757 EREKEALGQQERERARQRQ---------RAELEELRQQLEESSS-------ALTRALRAE 800
E E+ L +Q E Q++ + ++++L QQLE+ +S +LT+ ++
Sbjct: 832 ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891
Query: 801 FEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKE 860
E G +EQE+ Q+ +E E + +K+E +L ++ +E+ ++E
Sbjct: 892 LEDGNKEQEQTKQI-------LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 861 IELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLG 920
E E M K+++++ E+ K+L D+ ELE + +L ++ +
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQF----- 999
Query: 921 EAEGENLRLQGLVRQKERALEDAQAVNEQLSSER-SNLAQVIRQEFEDRLAASEEETRQA 979
N ++ + + + DA + E E+ +L +V R+E D ++ E++ Q
Sbjct: 1000 -----NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ 1054
Query: 980 KAEL-----ATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1034
EL LQ ++Q E+ E+ +++ KEE + E VK+ L EL E
Sbjct: 1055 AEELQEIHEIQLQEKEQ-EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113
Query: 1035 Q 1035
Q
Sbjct: 1114 Q 1114
Score = 80.9 bits (198), Expect = 6e-15
Identities = 135/674 (20%), Positives = 283/674 (41%), Gaps = 108/674 (16%)
Query: 457 LEELLHTLQLLEKEPDV-LPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPP 515
L++ ++ L+LL KE D L + H A + + L+ F ++
Sbjct: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVF---QSYQSAT 810
Query: 516 EDGTLLSEAKLQSIMSFLDEMEKSG------QDQLDSQQEGWVPEAGPGPLELGSEVSTS 569
+ T E +L + L ++E ++++Q++ E +++ ++
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV-QDLMQQ 869
Query: 570 VMRLKLEVEEKKQAMLLLQRALAQ----QRDLTARRVKETEKALSRQLQRQREHYEATIQ 625
+ + E+E+K +++ + + + +++ T + + E E + + + Q++ E Q
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 626 RHLAFIDQ---LIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMS 682
+ A D L E+ + + E + ++KQ+ + E + + E ++KK E +
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE-NT 988
Query: 683 ATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERAS 742
A E +++EK + K ++ + G+ + +L K+++ L +H EL
Sbjct: 989 ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
Query: 743 QRCLRQAEELRE----QL-EREKEA---------LGQQERERARQ---------RQRAEL 779
++ +QAEEL+E QL E+E+E G ++ E ++ +Q L
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL 1108
Query: 780 EELRQQLEESSSALTRA------LRAEFEKGREEQERRHQMELNTLKQQ--LELERQAWE 831
EL++QL++ S+ + L+A EK E + ++ NT Q+ +EL+ A E
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEK--LEVDLNKSLKENTFLQEQLVELKMLAEE 1166
Query: 832 AGR----------TRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEK 881
R T EE L E + + + E + + L + + +++E
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
Query: 882 AAESRIKRLRD-----------------------------------KYEAELSELEQSER 906
E++ L + + EA+L +L + +
Sbjct: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQN 1286
Query: 907 KLQERCSELKGQLGEAEGE----NLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
L + QL E E + ++ LV +KE AL+ +Q +SE+ + ++
Sbjct: 1287 TLNISFQQATHQLEEKENQIKSMKADIESLVTEKE-ALQKEGGNQQQAASEKESCITQLK 1345
Query: 963 QEFEDRLAA---SEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQH 1019
+E + + A +EE ++ K E+++L +QL V + +L+ KE A+SSLR Q+
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLS--KQLTDLNVQLQNSISLSEKEAAISSLRKQY 1403
Query: 1020 -EAAVKRADHLEEL 1032
E + D +++L
Sbjct: 1404 DEEKCELLDQVQDL 1417
Score = 72.4 bits (176), Expect = 2e-12
Identities = 98/438 (22%), Positives = 188/438 (42%), Gaps = 54/438 (12%)
Query: 578 EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLI-- 635
+E+ + +Q+ ++ + R + E EK L R Q + E + + + ++LI
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780
Query: 636 EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISE 695
E + + ++++ L++E + ++ + AQH +E + K + A + +
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH-VEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 696 KTKKIKEVTVRGLEPEIQKL---IAR----HKQEVRRLKSLHE--------------AEL 734
KT + KE+T + LE +I++L + R H+ E+ L S +E EL
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 735 LQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALT 794
L+ + + +L +E + L + R++Q+ E +R L++ L
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR--LQKDLRMLR 1957
Query: 795 RALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELR---- 850
+ + E E ++E ++ + ++ ++ LEL+ + R+ L +EQEL
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017
Query: 851 EEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYE----AELSELEQSER 906
E I K ++ E EL+ E L K+ +EK + +KR +YE A E+ R
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEK--DDDLKRTAKRYEEILDAREEEMTAKVR 2075
Query: 907 KLQERCSEL--KGQLGEAEGEN--------LRLQGLVRQKERALEDAQAVNEQLSSERSN 956
LQ + EL K Q + EN + LQ + QK + D++ ++ + N
Sbjct: 2076 DLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHN 2135
Query: 957 LAQVIRQEFEDRLAASEE 974
L EDRL E+
Sbjct: 2136 L--------EDRLKKYEK 2145
Score = 69.3 bits (168), Expect = 2e-11
Identities = 121/568 (21%), Positives = 237/568 (41%), Gaps = 122/568 (21%)
Query: 565 EVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATI 624
E++ + LK E ++ + LQ L +Q+ + + E L L++ ++
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNELQEQL-KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 625 QRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE----------LEI 674
+ + +QL+E K+L+E+ + V+EL + + E ++ HE LE
Sbjct: 1148 KENTFLQEQLVE-LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF 1206
Query: 675 KKLKELMS-----------ATEKARREKWIS-----------------EKTKKIKEV--- 703
KKL E ++ A +A+ + I+ +T K+KE
Sbjct: 1207 KKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266
Query: 704 ---TVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREK 760
TV LE ++++L +E L + Q +E+ +Q ++ + E L EK
Sbjct: 1267 KTCTVSELEAQLRQLT----EEQNTLNISFQQATHQLEEKENQ--IKSMKADIESLVTEK 1320
Query: 761 EALGQQ--ERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQM-ELN 817
EAL ++ +++A + + + +L+++L E+ +A+T EK E Q+ +LN
Sbjct: 1321 EALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1380
Query: 818 T-LKQQLELERQAWEAGRTRK----EEAWLLNREQEL--------REEI----------- 853
L+ + L + RK E+ LL++ Q+L +E+I
Sbjct: 1381 VQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSN 1440
Query: 854 ---------------RKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL 898
+ KE+++ + L++ A K+E + + + +++
Sbjct: 1441 KFSEWKKKAQSRFTQHQNTVKELQIQLE-LKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
Query: 899 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAV----NEQLSSER 954
E+E + K++++ S L+ +L + L+ + QK +E V N+Q E
Sbjct: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEH 1559
Query: 955 SNLAQVIR-------------QEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRV 1001
L Q ++ +E E+++ E + KAEL T ++ ELE V+ V
Sbjct: 1560 KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET----KKKELEHVNLSV 1615
Query: 1002 KTALARKEEAVSSL--RTQHEAAVKRAD 1027
K+ KEE + +L R + E+A K A+
Sbjct: 1616 KS----KEEELKALEDRLESESAAKLAE 1639
Score = 68.6 bits (166), Expect = 3e-11
Identities = 107/511 (20%), Positives = 208/511 (40%), Gaps = 79/511 (15%)
Query: 579 EKKQAMLLLQ--RALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIE 636
E K+ + LQ + L +++D RVKE E+ + T++ + + +E
Sbjct: 1558 EHKELVQKLQHFQELGEEKD---NRVKEAEEKI------------LTLENQVYSMKAELE 1602
Query: 637 DKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEK 696
KK E V ++E + +R+ A E+K+ E A K + + EK
Sbjct: 1603 TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEK 1662
Query: 697 TKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQL 756
++ K+ T L KL R ++ + L E QS+ R + EQ
Sbjct: 1663 EEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQE 1722
Query: 757 EREKEALGQ---QERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQ 813
E + + Q +E+ QR E E+L Q++ + + + FE + QER +
Sbjct: 1723 EADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE---ETVSSHFEMRCQYQERLIK 1779
Query: 814 ME------------LNTLKQQLELERQAW----------EAGRTRKEEAWLLN------- 844
+E + L+++LE + + + E G+ + L
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 845 ---REQELREEIRKGRDKEIELV------IHRLEADMALAKEESEKAAESRIKRLR--DK 893
+E+EL +I + + KE++ +HR+E + +K E +A + R + +
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 894 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNE---QL 950
E E +S + S ++ Q + E +L G R+K++ ++ + + L
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHNDLE---FKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 951 SSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEE 1010
E +++++E++ +E + K E L+ + L+++ R T LA+KE+
Sbjct: 1957 RKEHQQELEILKKEYD------QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ 2010
Query: 1011 AVSSLRTQHEAAVKRADHLE-ELLEQHRRPT 1040
L + + +A +E ELLE H+ T
Sbjct: 2011 ---ELEMTIKETINKAQEVEAELLESHQEET 2038
Score = 62.0 bits (149), Expect = 3e-09
Identities = 103/518 (19%), Positives = 229/518 (44%), Gaps = 50/518 (9%)
Query: 543 QLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRV 602
+L +++ V EA L L ++V + L+ + +E + L ++ + + L R
Sbjct: 1571 ELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE 1630
Query: 603 KETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTER 662
E+ L+ +L+R+ E A I++ L + Q+ E ++ + E+ ++EL + Q
Sbjct: 1631 SESAAKLA-ELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQ----- 1682
Query: 663 VAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQE 722
+ E E+ L+E + + E ++ E I ++ K E + Q + + +E
Sbjct: 1683 ------EREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE 1736
Query: 723 ---VRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQ-RAE 778
V + + +LLQ + + + E+R Q + E L + E A+Q + ++
Sbjct: 1737 KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQ---ERLIKLEHAEAKQHEDQSM 1793
Query: 779 LEELRQQLEESSS--ALTRALRAEFEKGREEQERRHQME-----LNTLKQQLELERQAWE 831
+ L+++LEE + +L A E E G+ + + +E + Q+ EL Q E
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853
Query: 832 AGRTRKEEAWLLNREQELREEIRKGRDKEIEL-VIHRLEA---DMALAKEESEKAAESRI 887
+ ++ ++ L+ +++ R E+ + K +L + +++ L +E +E+ ++S +
Sbjct: 1854 Q-KIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHL 1912
Query: 888 --KRLRDKYEAELSELE-------QSERKLQERCSELKGQLGEAEGENLRLQGLVRQK-- 936
+L EA+ ++LE + ++KL + L+ L E+ + +++++
Sbjct: 1913 VQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972
Query: 937 ERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEE 996
+ E + E L + ++ + + +EF +LA E+E E + EL E
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLE 2032
Query: 997 VHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLE 1034
H+ L +K + + + + A EE+L+
Sbjct: 2033 SHQEETNQLLKK------IAEKDDDLKRTAKRYEEILD 2064
Score = 58.9 bits (141), Expect = 2e-08
Identities = 99/483 (20%), Positives = 204/483 (42%), Gaps = 64/483 (13%)
Query: 572 RLKLEV-EEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEA-------- 622
+LK ++ EE++Q L A A T R++ + + QL + E+
Sbjct: 4 KLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
Query: 623 TIQRHLAFIDQL----IEDKKVLSEKCEAVVAELKQEDQRCTE---RVAQAQAQHELEIK 675
+Q + ++ L I++ S E++V +E + A +++
Sbjct: 64 KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMD-S 122
Query: 676 KLKELMSATEKARREKWISEKTKKIKEVT-VRGLEPEIQKLIARHKQEVRRLKSLHEAEL 734
+ ++L+ ++ +E+ I + + ++ RG E+ ++E ++L+ + L
Sbjct: 123 EAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI----L 178
Query: 735 LQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALT 794
QS +++ LR+ ELRE+L+ + QQ ++ ++ A LEE Q + + ++
Sbjct: 179 SQSQDKS----LRRIAELREELQMD-----QQAKKHLQEEFDASLEEKDQYISVLQTQVS 229
Query: 795 RALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIR 854
+++ R M ++ LK +LE QA KEE N E + +
Sbjct: 230 LL---------KQRLRNGPMNVDVLKPLPQLEPQAEVF---TKEE----NPESDGEPVVE 273
Query: 855 KGRD-KEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCS 913
G K +E + R++ +E K + I+ +++ SE E + +L ER
Sbjct: 274 DGTSVKTLETLQQRVKR-----QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQ 328
Query: 914 ELKG--QLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAA 971
EL+ L AE L Q L DA+ + EQL ++ + +++ + L
Sbjct: 329 ELEKIKDLHMAEKTKLITQ---------LRDAKNLIEQLEQDKGMVIAETKRQMHETLEM 379
Query: 972 SEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEE 1031
EEE Q ++ + + + + E+ + + A E+A+S+ + EA K ++E
Sbjct: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
Query: 1032 LLE 1034
++
Sbjct: 440 QIK 442
Score = 34.3 bits (77), Expect = 0.63
Identities = 44/234 (18%), Positives = 100/234 (42%), Gaps = 26/234 (11%)
Query: 780 EELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEE 839
++L+Q++ E L +AL R + ++ +QL+ E+G T+
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 840 AWLLNR--------EQELREEIRKGRDKEIELV-------IHRLEADMALAKEESEKAAE 884
L R ++E + + KE LV ++RL+ D + A + +
Sbjct: 63 QKLQLRVPSVESLFRSPIKESLFRSSSKE-SLVRTSSRESLNRLDLDSSTASFDPPSDMD 121
Query: 885 SRIKRLRDKYEA-ELSELEQSERKLQERCSELKGQLGE-------AEGENLRLQGLVRQ- 935
S + L ++ +L Q R+++ S +G+ E + E +LQG++ Q
Sbjct: 122 SEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
Query: 936 KERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQAR 989
++++L + E+L ++ + +++EF+ L ++ + +++ L+ R
Sbjct: 182 QDKSLRRIAELREELQMDQ-QAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQR 234
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 102 bits (255), Expect = 1e-21
Identities = 120/501 (23%), Positives = 232/501 (46%), Gaps = 55/501 (10%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR 611
V E E+ +E++ +L+ E E K+ + +LT +V++ + A
Sbjct: 928 VTERAEDEEEINAELTAKKRKLEDECSELKKDI--------DDLELTLAKVEKEKHATEN 979
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+++ E + I +L ++KK L E + + +L+ E+ + + +A+ + E
Sbjct: 980 KVKNLTEEMAGLDET----IAKLTKEKKALQEAHQQTLDDLQAEEDK-VNTLTKAKIKLE 1034
Query: 672 LEIKKLKELMSATEKAR----REKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ---EVR 724
++ L+ + +K R R K E K+ + ++ +E E Q+L + K+ E+
Sbjct: 1035 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEIS 1094
Query: 725 RLKSLHEAEL---LQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEE 781
L+S E E +Q ++ + R EEL E++E E+ + + E++R+ + ELEE
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKELQAR-IEELEEEIEAERASRAKAEKQRSDLSR--ELEE 1151
Query: 782 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 841
+ ++LEE+ A + + ++ E Q+ R +E TL+ + A RK+ A
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA-------TAATLRKKHAD 1204
Query: 842 LLNREQELREEIRKGRDK-EIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSE 900
+ E + +++ + K E E ++E D + E+ A+ ++++ E +LSE
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 901 LEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQV 960
L+ E + Q ++L Q G RLQ + R L++ +A+ QLS + Q
Sbjct: 1265 LKSKEEEQQRLINDLTAQRG-------RLQTESGEFSRQLDEKEALVSQLSRGK----QA 1313
Query: 961 IRQEFEDRLAASEEETRQAKAELATLQA--------RQQLELE-EVHRRVKTALARKEEA 1011
Q+ E+ EEE + A LQ+ R+Q E E E ++ AL++
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 1012 VSSLRTQHEA-AVKRADHLEE 1031
V+ RT++E A++R + LEE
Sbjct: 1374 VAQWRTKYETDAIQRTEELEE 1394
Score = 80.5 bits (197), Expect = 8e-15
Identities = 124/545 (22%), Positives = 231/545 (42%), Gaps = 88/545 (16%)
Query: 533 LDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK-----LEVEEKKQAMLLL 587
LDE K + ++ + Q E G ++L ++ R++ +E E +A
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALG-IQLQKKIKELQARIEELEEEIEAERASRAKAEK 1140
Query: 588 QRA-LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKV----LS 642
QR+ L+++ + + R++E A S Q++ ++ EA Q+ +++ + L
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNKKR-EAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 643 EKCEAVVAELKQED---QRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKK 699
+K VAEL ++ QR +++ + +++ ++EI L + KA+ +T +
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLE 1259
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKS--------LHEAELLQSD-ERASQRCLRQAE 750
+ ++ E E Q+LI + RL++ L E E L S R Q +Q E
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE 1319
Query: 751 ELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQER 810
EL+ QLE E +A + A Q R + + LR+Q EE + RA + E +
Sbjct: 1320 ELKRQLEEEIKA--KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 811 RHQMELNTLKQQLELE---RQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIE---LV 864
R + E + +++ ELE ++ + + +E +N + E+ ++ E+E L
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 865 IHRLEA------------DMALAK------------EESEKAAES---RIKRLRDKYEAE 897
+ R A D LA+ E S+K A S + ++++ YE
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEES 1497
Query: 898 LSELEQSERK---LQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSER 954
L +LE +R+ LQ+ S+L Q+ E + + + + + +Q+ E+
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEG--------------GKRIHELEKIKKQVEQEK 1543
Query: 955 SNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSS 1014
L Q +E E L E + R QLEL +V V +A K+E +
Sbjct: 1544 CEL-QAALEEAEASLEHEEGKI-----------LRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 1015 LRTQH 1019
L+ H
Sbjct: 1592 LKRNH 1596
Score = 72.8 bits (177), Expect = 2e-12
Identities = 103/483 (21%), Positives = 208/483 (43%), Gaps = 66/483 (13%)
Query: 566 VSTSVMRLKLEVEEKKQAMLLLQRA---LAQQ-RDLT------ARRVKETEKALSRQLQR 615
+ T + ++K EE + L+R L Q+ DLT +R+ E EK + +Q+++
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK-IKKQVEQ 1541
Query: 616 QREHYEATIQRHLAFIDQLIEDKKVLSEKCEA--VVAELKQEDQRCTERVAQAQAQHELE 673
++ +A ++ A ++ E+ K+L + E V +E+ ++ E + Q + H
Sbjct: 1542 EKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRI 1599
Query: 674 IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAE 733
++ ++ + A ++R + + + KK E + +E ++ + +R ++
Sbjct: 1600 VESMQSTLDAEIRSRND---AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQG-- 1654
Query: 734 LLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSAL 793
+L+ + LR E+L+EQL ER +AE+EELR LE++ +
Sbjct: 1655 ILKDTQIHLDDALRSQEDLKEQLAMV---------ERRANLLQAEIEELRATLEQTERSR 1705
Query: 794 TRALRAEFEKGREEQ----------ERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLL 843
A + + Q + ++E + + Q E+E EA ++ +
Sbjct: 1706 KIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI 1765
Query: 844 NREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQ 903
+ EE++K +D A + K+ E+ + RL + + L ++
Sbjct: 1766 TDAAMMAEELKKEQDTS---------AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 904 SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 963
+KL+ R EL+G++ + N +R+ ER +++ + Q +R N+ ++ Q
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE---LTYQTEEDRKNILRL--Q 1871
Query: 964 EFEDRLAA--------SEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSL 1015
+ D+L A +EE Q+ LA + + Q ELEE R A E V+ L
Sbjct: 1872 DLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR-KLQHELEEAEERADIA----ESQVNKL 1926
Query: 1016 RTQ 1018
R +
Sbjct: 1927 RVK 1929
Score = 63.5 bits (153), Expect = 1e-09
Identities = 91/364 (25%), Positives = 167/364 (45%), Gaps = 59/364 (16%)
Query: 676 KLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
K+K L+ + E + + E+ +KIK+ E+ K A+ K+ E + + L E
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKD--------ELAKSEAKRKELEEKMVTLLKEKND 892
Query: 735 LQSDERASQRCLRQAEELREQLEREK---EALGQQERERARQRQR--AELEELRQQLEES 789
LQ +A L AEE +QL + K EA ++ ERA + AEL +++LE+
Sbjct: 893 LQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 952
Query: 790 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQEL 849
S L + + +EL K +E E+ A E N+ + L
Sbjct: 953 CSELKKDI--------------DDLELTLAK--VEKEKHATE------------NKVKNL 984
Query: 850 REEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQ 909
EE+ G D+ I A + K+ ++A + + L+ + E +++ L +++ KL+
Sbjct: 985 TEEM-AGLDETI--------AKLTKEKKALQEAHQQTLDDLQAE-EDKVNTLTKAKIKLE 1034
Query: 910 ERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVI-RQEFEDR 968
++ +L+G L + + + L+ R+ E L+ AQ + +E+ L + + ++EFE
Sbjct: 1035 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEIS 1094
Query: 969 LAASEEETRQA-----KAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAV 1023
S+ E QA + ++ LQAR + ELEE + + A+ E+ S L + E
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKELQARIE-ELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153
Query: 1024 KRAD 1027
+R +
Sbjct: 1154 ERLE 1157
Score = 62.8 bits (151), Expect = 2e-09
Identities = 68/314 (21%), Positives = 146/314 (46%), Gaps = 40/314 (12%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ ++E+ ++ K+ L + E +R ELEE L + + L ++AE E +
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKR------KELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ER Q+ +K +++LE + E ++E + EL + RK D+ EL
Sbjct: 907 AEERCDQL----IKTKIQLEAKIKEVTERAEDEEEI---NAELTAKKRKLEDECSELKKD 959
Query: 867 RLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQERCSELKGQLGEA 922
+ ++ LAK E EK A E+++K L ++ + +++L + ++ LQE + L +A
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL-QA 1018
Query: 923 EGENLR---------------LQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFED 967
E + + L+G + Q+++ D + +L + LAQ + E+
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-LKLAQESIMDIEN 1077
Query: 968 RLAASEEETRQAKAELATLQARQQ------LELEEVHRRVKTALARKEEAVSSLRTQHEA 1021
+E+ ++ + E++ LQ++ + ++L++ + ++ + EE + + R
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Query: 1022 AVKRADHLEELLEQ 1035
A K+ L LE+
Sbjct: 1138 AEKQRSDLSRELEE 1151
Score = 48.9 bits (115), Expect = 2e-05
Identities = 62/296 (20%), Positives = 126/296 (42%), Gaps = 61/296 (20%)
Query: 779 LEELRQ----QLEESSSALTRAL--RAEFEKGREEQERRHQMELNTLKQQLELERQAW-- 830
LEE+R QL + A R R E+++ E +E ++ N ++ + ++ W
Sbjct: 779 LEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYN-IRSFMNVKHWPWMK 837
Query: 831 ---------EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEK 881
++ T KE A + Q++++E+ K K EL E + L KE+++
Sbjct: 838 LFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELE----EKMVTLLKEKND- 892
Query: 882 AAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALE 941
L+ + +AE L +E ERC +L ++L+ +++ E
Sbjct: 893 --------LQLQVQAEAEGLADAE----ERCDQLIKT-------KIQLEAKIKEVTERAE 933
Query: 942 DAQAVNEQLSSERSNLA-------------QVIRQEFEDRLAASEEETRQAKAELATLQ- 987
D + +N +L++++ L ++ + E A+E + + E+A L
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 993
Query: 988 -----ARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1038
+++ L+E H++ L +E+ V++L ++ D LE LEQ ++
Sbjct: 994 TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK 1049
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 102 bits (255), Expect = 1e-21
Identities = 120/501 (23%), Positives = 232/501 (46%), Gaps = 55/501 (10%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSR 611
V E E+ +E++ +L+ E E K+ + +LT +V++ + A
Sbjct: 928 VTERAEDEEEINAELTAKKRKLEDECSELKKDI--------DDLELTLAKVEKEKHATEN 979
Query: 612 QLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHE 671
+++ E + I +L ++KK L E + + +L+ E+ + + +A+ + E
Sbjct: 980 KVKNLTEEMAGLDET----IAKLTKEKKALQEAHQQTLDDLQAEEDK-VNTLTKAKIKLE 1034
Query: 672 LEIKKLKELMSATEKAR----REKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ---EVR 724
++ L+ + +K R R K E K+ + ++ +E E Q+L + K+ E+
Sbjct: 1035 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEIS 1094
Query: 725 RLKSLHEAEL---LQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEE 781
L+S E E +Q ++ + R EEL E++E E+ + + E++R+ + ELEE
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKELQAR-IEELEEEIEAERASRAKAEKQRSDLSR--ELEE 1151
Query: 782 LRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAW 841
+ ++LEE+ A + + ++ E Q+ R +E TL+ + A RK+ A
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA-------TAATLRKKHAD 1204
Query: 842 LLNREQELREEIRKGRDK-EIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSE 900
+ E + +++ + K E E ++E D + E+ A+ ++++ E +LSE
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSE 1264
Query: 901 LEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQV 960
L+ E + Q ++L Q G RLQ + R L++ +A+ QLS + Q
Sbjct: 1265 LKSKEEEQQRLINDLTAQRG-------RLQTESGEFSRQLDEKEALVSQLSRGK----QA 1313
Query: 961 IRQEFEDRLAASEEETRQAKAELATLQA--------RQQLELE-EVHRRVKTALARKEEA 1011
Q+ E+ EEE + A LQ+ R+Q E E E ++ AL++
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 1012 VSSLRTQHEA-AVKRADHLEE 1031
V+ RT++E A++R + LEE
Sbjct: 1374 VAQWRTKYETDAIQRTEELEE 1394
Score = 80.5 bits (197), Expect = 8e-15
Identities = 124/545 (22%), Positives = 231/545 (42%), Gaps = 88/545 (16%)
Query: 533 LDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLK-----LEVEEKKQAMLLL 587
LDE K + ++ + Q E G ++L ++ R++ +E E +A
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALG-IQLQKKIKELQARIEELEEEIEAERASRAKAEK 1140
Query: 588 QRA-LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKV----LS 642
QR+ L+++ + + R++E A S Q++ ++ EA Q+ +++ + L
Sbjct: 1141 QRSDLSRELEEISERLEEAGGATSAQIEMNKKR-EAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 643 EKCEAVVAELKQED---QRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKK 699
+K VAEL ++ QR +++ + +++ ++EI L + KA+ +T +
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLE 1259
Query: 700 IKEVTVRGLEPEIQKLIARHKQEVRRLKS--------LHEAELLQSD-ERASQRCLRQAE 750
+ ++ E E Q+LI + RL++ L E E L S R Q +Q E
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE 1319
Query: 751 ELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQER 810
EL+ QLE E +A + A Q R + + LR+Q EE + RA + E +
Sbjct: 1320 ELKRQLEEEIKA--KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 811 RHQMELNTLKQQLELE---RQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIE---LV 864
R + E + +++ ELE ++ + + +E +N + E+ ++ E+E L
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 865 IHRLEA------------DMALAK------------EESEKAAES---RIKRLRDKYEAE 897
+ R A D LA+ E S+K A S + ++++ YE
Sbjct: 1438 VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEES 1497
Query: 898 LSELEQSERK---LQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSER 954
L +LE +R+ LQ+ S+L Q+ E + + + + + +Q+ E+
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEG--------------GKRIHELEKIKKQVEQEK 1543
Query: 955 SNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSS 1014
L Q +E E L E + R QLEL +V V +A K+E +
Sbjct: 1544 CEL-QAALEEAEASLEHEEGKI-----------LRIQLELNQVKSEVDRKIAEKDEEIDQ 1591
Query: 1015 LRTQH 1019
L+ H
Sbjct: 1592 LKRNH 1596
Score = 72.8 bits (177), Expect = 2e-12
Identities = 103/483 (21%), Positives = 208/483 (43%), Gaps = 66/483 (13%)
Query: 566 VSTSVMRLKLEVEEKKQAMLLLQRA---LAQQ-RDLT------ARRVKETEKALSRQLQR 615
+ T + ++K EE + L+R L Q+ DLT +R+ E EK + +Q+++
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK-IKKQVEQ 1541
Query: 616 QREHYEATIQRHLAFIDQLIEDKKVLSEKCEA--VVAELKQEDQRCTERVAQAQAQHELE 673
++ +A ++ A ++ E+ K+L + E V +E+ ++ E + Q + H
Sbjct: 1542 EKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRI 1599
Query: 674 IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAE 733
++ ++ + A ++R + + + KK E + +E ++ + +R ++
Sbjct: 1600 VESMQSTLDAEIRSRND---AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQG-- 1654
Query: 734 LLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSAL 793
+L+ + LR E+L+EQL ER +AE+EELR LE++ +
Sbjct: 1655 ILKDTQIHLDDALRSQEDLKEQLAMV---------ERRANLLQAEIEELRATLEQTERSR 1705
Query: 794 TRALRAEFEKGREEQ----------ERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLL 843
A + + Q + ++E + + Q E+E EA ++ +
Sbjct: 1706 KIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI 1765
Query: 844 NREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQ 903
+ EE++K +D A + K+ E+ + RL + + L ++
Sbjct: 1766 TDAAMMAEELKKEQDTS---------AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 904 SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 963
+KL+ R EL+G++ + N +R+ ER +++ + Q +R N+ ++ Q
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKE---LTYQTEEDRKNILRL--Q 1871
Query: 964 EFEDRLAA--------SEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSL 1015
+ D+L A +EE Q+ LA + + Q ELEE R A E V+ L
Sbjct: 1872 DLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFR-KLQHELEEAEERADIA----ESQVNKL 1926
Query: 1016 RTQ 1018
R +
Sbjct: 1927 RVK 1929
Score = 63.5 bits (153), Expect = 1e-09
Identities = 91/364 (25%), Positives = 167/364 (45%), Gaps = 59/364 (16%)
Query: 676 KLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
K+K L+ + E + + E+ +KIK+ E+ K A+ K+ E + + L E
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKD--------ELAKSEAKRKELEEKMVTLLKEKND 892
Query: 735 LQSDERASQRCLRQAEELREQLEREK---EALGQQERERARQRQR--AELEELRQQLEES 789
LQ +A L AEE +QL + K EA ++ ERA + AEL +++LE+
Sbjct: 893 LQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 952
Query: 790 SSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQEL 849
S L + + +EL K +E E+ A E N+ + L
Sbjct: 953 CSELKKDI--------------DDLELTLAK--VEKEKHATE------------NKVKNL 984
Query: 850 REEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQ 909
EE+ G D+ I A + K+ ++A + + L+ + E +++ L +++ KL+
Sbjct: 985 TEEM-AGLDETI--------AKLTKEKKALQEAHQQTLDDLQAE-EDKVNTLTKAKIKLE 1034
Query: 910 ERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVI-RQEFEDR 968
++ +L+G L + + + L+ R+ E L+ AQ + +E+ L + + ++EFE
Sbjct: 1035 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEIS 1094
Query: 969 LAASEEETRQA-----KAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAV 1023
S+ E QA + ++ LQAR + ELEE + + A+ E+ S L + E
Sbjct: 1095 NLQSKIEDEQALGIQLQKKIKELQARIE-ELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153
Query: 1024 KRAD 1027
+R +
Sbjct: 1154 ERLE 1157
Score = 62.8 bits (151), Expect = 2e-09
Identities = 68/314 (21%), Positives = 146/314 (46%), Gaps = 40/314 (12%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ ++E+ ++ K+ L + E +R ELEE L + + L ++AE E +
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKR------KELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ER Q+ +K +++LE + E ++E + EL + RK D+ EL
Sbjct: 907 AEERCDQL----IKTKIQLEAKIKEVTERAEDEEEI---NAELTAKKRKLEDECSELKKD 959
Query: 867 RLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQERCSELKGQLGEA 922
+ ++ LAK E EK A E+++K L ++ + +++L + ++ LQE + L +A
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL-QA 1018
Query: 923 EGENLR---------------LQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFED 967
E + + L+G + Q+++ D + +L + LAQ + E+
Sbjct: 1019 EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-LKLAQESIMDIEN 1077
Query: 968 RLAASEEETRQAKAELATLQARQQ------LELEEVHRRVKTALARKEEAVSSLRTQHEA 1021
+E+ ++ + E++ LQ++ + ++L++ + ++ + EE + + R
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Query: 1022 AVKRADHLEELLEQ 1035
A K+ L LE+
Sbjct: 1138 AEKQRSDLSRELEE 1151
Score = 48.9 bits (115), Expect = 2e-05
Identities = 62/296 (20%), Positives = 126/296 (42%), Gaps = 61/296 (20%)
Query: 779 LEELRQ----QLEESSSALTRAL--RAEFEKGREEQERRHQMELNTLKQQLELERQAW-- 830
LEE+R QL + A R R E+++ E +E ++ N ++ + ++ W
Sbjct: 779 LEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYN-IRSFMNVKHWPWMK 837
Query: 831 ---------EAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEK 881
++ T KE A + Q++++E+ K K EL E + L KE+++
Sbjct: 838 LFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELE----EKMVTLLKEKND- 892
Query: 882 AAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALE 941
L+ + +AE L +E ERC +L ++L+ +++ E
Sbjct: 893 --------LQLQVQAEAEGLADAE----ERCDQLIKT-------KIQLEAKIKEVTERAE 933
Query: 942 DAQAVNEQLSSERSNLA-------------QVIRQEFEDRLAASEEETRQAKAELATLQ- 987
D + +N +L++++ L ++ + E A+E + + E+A L
Sbjct: 934 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDE 993
Query: 988 -----ARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1038
+++ L+E H++ L +E+ V++L ++ D LE LEQ ++
Sbjct: 994 TIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKK 1049
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 102 bits (253), Expect = 2e-21
Identities = 182/770 (23%), Positives = 312/770 (40%), Gaps = 127/770 (16%)
Query: 307 RSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPR 366
R+ E +L D + A ++K R A E ++K AL+ ++ +
Sbjct: 728 RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLE-EEKSALQGRQRQAEQEATVAREE 786
Query: 367 ETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPED 426
+ R+ +R + A Q L+ G L A L E Q P
Sbjct: 787 QERLEELRLEQE--------VARQGLE-----GSLRVAEQAQEAL-------EQQLPTLR 826
Query: 427 RTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYA 486
+ L + A + ++ + ++R + + L+ +E + L + +
Sbjct: 827 HERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLV 886
Query: 487 WASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDS 546
A E S E+ +L E E + +L + + +++E GQ L +
Sbjct: 887 AAEREGRTLS------EEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA 940
Query: 547 QQEGWVPEAGPGPLELGSEVSTSV----MRLKL-EVEEKKQAMLLLQRALAQQRDLTARR 601
++ AG + ++ S+ M KL + E + QA L QRA A + DL +R
Sbjct: 941 KETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRA-AHEEDL--QR 997
Query: 602 VKETEKALSRQLQRQREHYEATIQRHLA-FIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
++ ++A R+L+ +R ++ +QR + +L +K+ LSE+ A+ E +
Sbjct: 998 LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Query: 661 ERVAQAQAQHELEIKKLKELMSATEKA--------RREKWISEKTKKIKEVTVRGLEPEI 712
QA + E E L E + T + R+K ++ ++ TV L E+
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL 1117
Query: 713 QKLIAR-------HKQEVRRLKSLHEAELLQSDERASQR--CLRQAEELREQLEREKEAL 763
+ L A+ H QEVRRL+ Q+ + QR CLR+AEELR QL
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQE-------QARDLGKQRDSCLREAEELRTQL------- 1163
Query: 764 GQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQL 823
+ E AR R EL E +++L ES ++GRE Q + E L++ L
Sbjct: 1164 --RLLEDARDGLRRELLEAQRKLRES------------QEGREVQ----RQEAGELRRSL 1205
Query: 824 ELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAA 883
G KE L +ELR ++K + I L + + + LA E + A
Sbjct: 1206 ---------GEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTA 1256
Query: 884 ESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLR-------LQGLVRQK 936
+ + + L E+E+S + + EL+ Q+ + EN R LQG +
Sbjct: 1257 ---VGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALG 1313
Query: 937 ERALEDAQ----AVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQL 992
ERA ++++ + ++L ++L +V+RQE L ++ + ++ + E T + R
Sbjct: 1314 ERAEKESRRETLGLRQRLLKGEASL-EVMRQE----LQVAQRKLQEQEGEFRTRERRLLG 1368
Query: 993 ELEEV---------HRR---VKTALARKEEAVSSLRTQHEAAVKRADHLE 1030
LEE H R +K AR E A LR AA RA LE
Sbjct: 1369 SLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRL--SAAEGRAQGLE 1416
Score = 97.8 bits (242), Expect = 5e-20
Identities = 134/516 (25%), Positives = 234/516 (45%), Gaps = 70/516 (13%)
Query: 546 SQQEGWVPEAGPGPLELGSE----VSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARR 601
S G P GP P S + +++ + +L+V++ + Q L R +
Sbjct: 500 SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDS 559
Query: 602 VKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTE 661
E +AL QLQR R+ + +Q H ED + ++ + L +E
Sbjct: 560 ESE-RRALEEQLQRLRDKTDGAMQAH--------EDAQREVQRLRSANELLSREKSNLAH 610
Query: 662 RVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ 721
+ AQ Q E ++ ++L +A E+ RR++ ++ ++ +E V+ ++L H+Q
Sbjct: 611 SLQVAQQQAEELRQEREKLQAAQEELRRQR---DRLEEEQEDAVQDGARVRRELERSHRQ 667
Query: 722 --EVRRLKSLHEAELLQSDERAS----QRCLRQAEELREQLEREKEALGQQERERARQRQ 775
++ +S+ EL++ E S QR + QAE+ K G+ E E + +
Sbjct: 668 LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKL 727
Query: 776 RAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRT 835
RAE L+ L + S AL +L + +++LN L QLE E+ A + GR
Sbjct: 728 RAEEASLQDSLSKLS-ALNESLAQD------------KLDLNRLVAQLEEEKSALQ-GRQ 773
Query: 836 RK--EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDK 893
R+ +EA + EQE EE+R E E+ LE + +A E++++A E ++ LR +
Sbjct: 774 RQAEQEATVAREEQERLEELRL----EQEVARQGLEGSLRVA-EQAQEALEQQLPTLRHE 828
Query: 894 YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSE 953
+LQE+ ++L QL E E + + +++ ALE A E L+ E
Sbjct: 829 -----------RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKE 877
Query: 954 RSNLA-QVIRQEFEDRLAASEEETR-------------QAKAELATLQARQQLELEEVHR 999
+ LA Q++ E E R SEE TR + + +LA L+AR++ +LE +
Sbjct: 878 HAGLAVQLVAAEREGR-TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARRE-QLEAEGQ 935
Query: 1000 RVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQ 1035
+ A ++ LR Q A ++A +EL+ Q
Sbjct: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ 971
Score = 94.4 bits (233), Expect = 5e-19
Identities = 123/511 (24%), Positives = 228/511 (44%), Gaps = 68/511 (13%)
Query: 558 GPLELGSEVSTSVMRLKL--EVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQR 615
G ++ + V RL+ E+ ++++ L +AQQ+ R+ +E +A +L+R
Sbjct: 579 GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRR 638
Query: 616 QREHYE----------ATIQRHLAF----IDQLIEDKKVLSEKC----EAVVAELKQEDQ 657
QR+ E A ++R L ++QL + VL+++ EA+ Q D
Sbjct: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDM 698
Query: 658 RCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEP--EIQKL 715
E+ A+A + E +++ +S T+ E + + K+ + + ++ +L
Sbjct: 699 LQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRL 758
Query: 716 IARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQ---------Q 766
+A+ ++E KS + Q+++ A+ R+ +E E+L E+E Q +
Sbjct: 759 VAQLEEE----KSALQGRQRQAEQEAT--VAREEQERLEELRLEQEVARQGLEGSLRVAE 812
Query: 767 ERERARQRQRAELEELRQQLEESSSALTRALRA---EFEKGREEQERRHQMELNTLKQQL 823
+ + A ++Q L R QL+E + L+R L E E+ R E +R+ + +++
Sbjct: 813 QAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKE 872
Query: 824 ELERQ----------AWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMA 873
L ++ A GRT EEA L E+E E G E++ + +LEA
Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALE----GSLFEVQRQLAQLEA--- 925
Query: 874 LAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCS---ELKGQ-LGEAEGE---N 926
+ E +A + ++ EL+ L Q QE+ S EL Q L +AE E +
Sbjct: 926 --RREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQAS 983
Query: 927 LRLQGLVRQKE--RALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELA 984
LR Q +++ R + +A +L +ER+ L +++E E+ LA E E + E+A
Sbjct: 984 LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIA 1043
Query: 985 TLQARQQLELEEVHRRVKTALARKEEAVSSL 1015
LQ + L + AL+ KE ++L
Sbjct: 1044 ALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
Score = 86.3 bits (212), Expect = 1e-16
Identities = 182/794 (22%), Positives = 322/794 (40%), Gaps = 165/794 (20%)
Query: 282 QVQRRGAGAARLEHLLQAKRE----EQRQRSGEGTLLDLHQQKEAARRKAREEKA--RQA 335
++Q R A R E +++RE QR GE +L + Q+ + A+RK +E++ R
Sbjct: 1305 ELQGRLALGERAEK--ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTR 1362
Query: 336 RRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAHQALKAN 395
R + L++ R Q+ A RG E ++ R A EL
Sbjct: 1363 ERRLLGSLEEARGTEKQQLDHA-RG-----LELKLEAARAEAAEL--------------- 1401
Query: 396 NTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSRG 455
G L AA E R Q + A+ A + R + G
Sbjct: 1402 --GLRLSAA--------------------EGRAQGLEAELA-----RVEVQRRAAEAQLG 1434
Query: 456 PLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEP- 514
L L L + P PRP R A A E L + + + S P P
Sbjct: 1435 GLRSALRRGLGLGRAPSPAPRPVPGSPARDAPA--EGSGEGLNSPSTLECSPGSQPPSPG 1492
Query: 515 ----PEDGTLLSEAKLQSIMSFLDEMEKSGQ--DQLDSQQEGWVPEAGPGPLELGSEVST 568
P L EA ++ FL E+ + + D+L +Q S ++
Sbjct: 1493 PATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQT---------------SALNR 1537
Query: 569 SVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHL 628
+ ++ E + LQ+A+A+ + R V + +L Q E + +
Sbjct: 1538 QLAEMEAERDSATSRARQLQKAVAESEE-ARRSVDGRLSGVQAELALQEESVRRSERERR 1596
Query: 629 AFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKAR 688
A +DQ+ L +A +EL+ ++ ++ A + + E + ++LKE++ A+E
Sbjct: 1597 ATLDQVA----TLERSLQATESELRASQEKISKMKAN-ETKLEGDKRRLKEVLDASES-- 1649
Query: 689 REKWISEKTKKIKEVTVRGLEPEIQKL-IARHKQEVRRLKSLHEAELLQSDERASQRCLR 747
+T K+ E+ R LE E+Q+ + +E +A+ LQ + QR +
Sbjct: 1650 -------RTVKL-ELQRRSLEGELQRSRLGLSDREA-------QAQALQDRVDSLQRQVA 1694
Query: 748 QAE----ELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSAL--TRALRAEF 801
+E L+ +ER AL + E R + + L + L +SS++L TR
Sbjct: 1695 DSEVKAGTLQLTVERLNGALAKVEESEGALRDK--VRGLTEALAQSSASLNSTRDKNLHL 1752
Query: 802 EKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEI 861
+K E Q+ L+++L+ RQA RK+ + L + Q LR E+
Sbjct: 1753 QKALTACEHDRQV----LQERLDAARQA--LSEARKQSSSLGEQVQTLRGEVA------- 1799
Query: 862 ELVIHRLEADMALA--------KEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCS 913
+L + R+EA+ L ++E E AA + +++L+D E L++ LQ +
Sbjct: 1800 DLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----ERRLLQERLGSLQRALA 1855
Query: 914 ELKGQLGEAEGENLRLQG-----------LVRQKERALEDAQAVNEQLSSERSNLAQVIR 962
+L+ + E E LRL+ + R+K R+ ED +LS+E+ L + +
Sbjct: 1856 QLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTV----RLSAEKGRLDRTLT 1911
Query: 963 QEFEDRLAASEEETRQAKAELATLQA------------RQQLELEEVHRRVKTALARKEE 1010
E LA ++ + +Q +A++ L+ +QQLEL++ R+++A A+ E
Sbjct: 1912 GA-ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTER 1970
Query: 1011 AVSSLRTQHEAAVK 1024
+ + H V+
Sbjct: 1971 TLEARERAHRQRVR 1984
Score = 76.3 bits (186), Expect = 1e-13
Identities = 88/363 (24%), Positives = 166/363 (45%), Gaps = 39/363 (10%)
Query: 677 LKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQ 736
L++ +S +E RR + E+ +++++ T ++ ++EV+RL+S +E LL
Sbjct: 552 LRKQLSDSESERRA--LEEQLQRLRDKTDGAMQAHEDA-----QREVQRLRSANE--LLS 602
Query: 737 SDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRA 796
++ L+ A++ E+L +E+E L + E RQR R E EE +++ +
Sbjct: 603 REKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE-EEQEDAVQDGAR----- 656
Query: 797 LRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKG 856
+R E E+ + E+ K+ +E+ R+A R + L + E+ E + K
Sbjct: 657 VRRELERSHRQLEQLEGKRSVLAKELVEV-REA--LSRATLQRDMLQAEKAEVAEALTKA 713
Query: 857 RDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELK 916
+EL ++++ K +E+A+ L+D LS+L L + +L
Sbjct: 714 EAGRVEL-------ELSMTKLRAEEAS------LQDS----LSKLSALNESLAQDKLDLN 756
Query: 917 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 976
+ + E E LQG RQ E+ A+ E+L R +V RQ E L +E+
Sbjct: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE-QEVARQGLEGSLRVAEQAQ 815
Query: 977 RQAKAELATLQ---ARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELL 1033
+ +L TL+ ++ Q +L ++ R++ E+A + Q EA + A E L
Sbjct: 816 EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875
Query: 1034 EQH 1036
++H
Sbjct: 876 KEH 878
Score = 65.1 bits (157), Expect = 3e-10
Identities = 173/828 (20%), Positives = 309/828 (37%), Gaps = 102/828 (12%)
Query: 244 TGGSTGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREE 303
TG GL ++ T+E+A + Q V +R Q R AA E L + +RE+
Sbjct: 945 TGELAGLRQQIIATQEKASLDKELMAQKLVQAER--EAQASLREQRAAHEEDLQRLQREK 1002
Query: 304 Q---RQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERG 360
+ R+ E L Q+E AR E ++ I LQQ+R + +E+
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERD-EGLLLAESEKQ 1061
Query: 361 PPENPRETRVPGMRQPAQELSPTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEP 420
+ +E+ + +++L T A +L+ + DR + +S E
Sbjct: 1062 QALSLKESEKTAL---SEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTS-EL 1117
Query: 421 QQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAKSR--GPLEELLHTLQLLEKEPDVLPRP- 477
+ R + A L+ A G + EEL L+LLE D L R
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRREL 1177
Query: 478 -------RTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIM 530
R GR E + + ++ L E +E++ S +
Sbjct: 1178 LEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS-L 1236
Query: 531 SFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELG-SEVSTSVMRLKLEVEEKKQAMLLLQR 589
+E ++ L+ + EA G L G EV S + + E++E ++ M +L
Sbjct: 1237 KLANEDKEQKLALLEEARTAVGKEA--GELRTGLQEVERSRLEARRELQELRRQMKMLD- 1293
Query: 590 ALAQQRDLTARRVKETEKALSRQLQRQREHYEATI---QRHL---AFIDQLIEDKKVLSE 643
+ R + E + L+ + ++E T+ QR L A ++ + ++ +V
Sbjct: 1294 ---SENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
Query: 644 KCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEV 703
K + E + ++R + +A+ + ++ + L E AR E E
Sbjct: 1351 KLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG 1410
Query: 704 TVRGLEPEIQKLIARHKQEVRRLKSLHEA---------------------ELLQSDERAS 742
+GLE E+ ++ + + +L L A + S
Sbjct: 1411 RAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGS 1470
Query: 743 QRCLRQAEELREQLEREKEALG--------QQERERARQRQRAELEEL------RQQLEE 788
L L + + G + E R R L+EL R +L
Sbjct: 1471 GEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRT 1530
Query: 789 SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
+SAL R L AE E R+ R + + + E R GR +A L +E+
Sbjct: 1531 QTSALNRQL-AEMEAERDSATSRARQLQKAVAESEEARRSV--DGRLSGVQAELALQEES 1587
Query: 849 LREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKL 908
+R R+ R D E S +A ES ++ ++K +S+++ +E KL
Sbjct: 1588 VRRSERE----------RRATLDQVATLERSLQATESELRASQEK----ISKMKANETKL 1633
Query: 909 QERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDR 968
+ LK L +E ++L+ + R+LE + S+R AQ + +DR
Sbjct: 1634 EGDKRRLKEVLDASESRTVKLE----LQRRSLEGELQRSRLGLSDREAQAQAL----QDR 1685
Query: 969 LAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLR 1016
+ + + + ++ + TLQ + R+ ALA+ EE+ +LR
Sbjct: 1686 VDSLQRQVADSEVKAGTLQLTVE--------RLNGALAKVEESEGALR 1725
Score = 63.2 bits (152), Expect = 1e-09
Identities = 117/500 (23%), Positives = 203/500 (40%), Gaps = 72/500 (14%)
Query: 598 TARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIED--KKVLSEKCEAVVAELKQE 655
T+R V+E LS L+ EA +++ QL E KVL EK +A+ + +
Sbjct: 331 TSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD---LAQQQMQ 387
Query: 656 DQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVR---GLEPE- 711
++ + L +K+L++ EK + K ++EK + ++ + ++ LE E
Sbjct: 388 SDLDKADLSARVTELGLAVKRLEK--QNLEKDQVNKDLTEKLEALESLRLQEQAALETED 445
Query: 712 ---IQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQER 768
+Q+ + Q V L L ER + L Q R
Sbjct: 446 GEGLQQTLRDLAQAV--LSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGR 503
Query: 769 ERARQRQRAELEELRQQLEESSSAL-TRALRAEFEKGREEQERRHQMELNTLKQQL---E 824
R+ +R + L SAL R L+ + +GR E Q L TL++QL E
Sbjct: 504 GRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEAS---QDLLGTLRKQLSDSE 560
Query: 825 LERQAWEAG--RTRKEEAWLLNREQELREEIRKGRD------KEIELVIHRLEADMALAK 876
ER+A E R R + + ++ + E+++ R +E + H L+ A+
Sbjct: 561 SERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAE 620
Query: 877 E-----ESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQG 931
E E +AA+ ++R RD+ E E + Q +++ QL + EG+ L
Sbjct: 621 ELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680
Query: 932 LVRQKERALEDAQAVNEQLSSERSNLAQVI------RQEFE-----------------DR 968
+ + AL A + L +E++ +A+ + R E E +
Sbjct: 681 ELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSK 740
Query: 969 LAASEEETRQAKAELATLQARQQLELEEVHRRVKTA-----LARKE-EAVSSLRTQHEAA 1022
L+A E Q K +L L A+ + E + R + A +AR+E E + LR + E A
Sbjct: 741 LSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVA 800
Query: 1023 -------VKRADHLEELLEQ 1035
++ A+ +E LEQ
Sbjct: 801 RQGLEGSLRVAEQAQEALEQ 820
Score = 58.5 bits (140), Expect = 3e-08
Identities = 119/585 (20%), Positives = 241/585 (41%), Gaps = 109/585 (18%)
Query: 533 LDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEV-EEKKQAMLLLQRAL 591
L E + S + +L + QEG +A V RL+ ++ + KK+ L Q+ L
Sbjct: 148 LQEEQASYRRKLQAYQEGQQRQA------------QLVQRLQGKILQYKKRCSELEQQLL 195
Query: 592 AQQRDLTARRVKETEKA--LSRQLQRQREHYE--ATIQRHLAFIDQLIEDKKVLSEKCEA 647
+ +L +R+++TE + L L R E + A++ + A + + ++ ++
Sbjct: 196 ERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSE 255
Query: 648 VVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRG 707
+ ++ + RC + + +A E + S W + V R
Sbjct: 256 DIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW-------RQVVGFRR 308
Query: 708 LEPEIQKLIARHKQEV-----RRLKSLHEAEL-----LQSDERASQRCLRQAEELREQLE 757
L E++ R ++ R +++ EA L L+ E ++ L + L+ QLE
Sbjct: 309 LVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLE 368
Query: 758 REKEALGQQERERARQRQRAELE--ELRQQLEESSSALTRALRAEFEK---GREEQERRH 812
+ +E++ A+Q+ +++L+ +L ++ E A+ R + EK ++ E+
Sbjct: 369 EQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLE 428
Query: 813 QMELNTLKQQLELERQAWEA-GRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRL--- 868
+E L++Q LE + E +T ++ A + + E ++ G ++ + L
Sbjct: 429 ALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQL-SGSERTADASNGSLRGL 487
Query: 869 ------------------------------EADMALAKEESEKAAESRIKRLRDKYEA-- 896
+ +AL K + +++ +R +YEA
Sbjct: 488 SGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHK-RQLQVQDMRGRYEASQ 546
Query: 897 --------ELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNE 948
+LS+ E R L+E+ L+ + A + +R ++ ++ NE
Sbjct: 547 DLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH-------EDAQREVQRLRSANE 599
Query: 949 QLSSERSNLA---QVIRQEFE------DRLAASEEETRQAKAELATLQ-------ARQQL 992
LS E+SNLA QV +Q+ E ++L A++EE R+ + L Q AR +
Sbjct: 600 LLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR 659
Query: 993 ELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHR 1037
ELE HR+++ L K ++ + A+ RA ++L+ +
Sbjct: 660 ELERSHRQLE-QLEGKRSVLAKELVEVREALSRATLQRDMLQAEK 703
Score = 56.6 bits (135), Expect = 1e-07
Identities = 93/398 (23%), Positives = 167/398 (41%), Gaps = 53/398 (13%)
Query: 662 RVAQAQAQHELEIKKLKELMSATEKA------RREKWISEKTKKIKEVTVRGL-EPEIQK 714
R + + E I+ L+ + EK ++ I+ I+E+ R L +PE
Sbjct: 7 RAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPV 66
Query: 715 LIARHKQEVRRLKSLHEA-ELLQSDERASQRCLRQAEELREQL--------EREKEALGQ 765
L+ E+ L SL E +LLQ + + L Q+ R++L ER ++AL
Sbjct: 67 LLP--ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRL 124
Query: 766 QERERARQRQRA---ELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQ 822
+ E Q R + ELR+QL+E ++ R L+A +E Q+R+ Q+ +
Sbjct: 125 EPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAY----QEGQQRQAQLVQRLQGKI 180
Query: 823 LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKA 882
L+ +++ E E LL R EL ++ + RD E H + + AL + E E+
Sbjct: 181 LQYKKRCSEL------EQQLLERSGELEQQ--RLRDTE-----HSQDLESALIRLEEEQQ 227
Query: 883 AESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED 942
+ + ++ +L + + + L E ++ E + R++E
Sbjct: 228 RSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE----- 282
Query: 943 AQAVNEQLSSERSNLAQVIRQEFEDRLAASEEE--TRQAKAELATLQARQQLELEEVHRR 1000
++ N S+E S L + RQ R SE + T + +L AR ++E
Sbjct: 283 -ESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLG 341
Query: 1001 VKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1038
+ T L E ++ EAA+++ L+ LE+ R
Sbjct: 342 LSTGLRLAE-------SRAEAALEKQALLQAQLEEQLR 372
Score = 53.5 bits (127), Expect = 1e-06
Identities = 90/407 (22%), Positives = 177/407 (43%), Gaps = 56/407 (13%)
Query: 660 TERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARH 719
T ++Q ++ L ++ L+S E+ + + ++ +++++ + E +L ++
Sbjct: 56 TRNLSQPESPVLLPATEMASLLSLQEE---NQLLQQELSRVEDLLAQS-RAERDELAIKY 111
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEAL---------GQQERER 770
RL+ E + + + + +RQ+ ELR QL+ E+ + GQQ + +
Sbjct: 112 NAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQ 171
Query: 771 ARQRQRAEL-------EELRQQLEESSSAL----------TRALRAEFEKGREEQERRHQ 813
QR + ++ EL QQL E S L ++ L + + EEQ+R
Sbjct: 172 LVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSAS 231
Query: 814 M-ELNT-LKQQLELERQAWEAGRTRKEEA------WL-LNREQELREEIRKGRDKEIELV 864
+ ++N L++QL+ QA A + E+ W +E E RE + ++
Sbjct: 232 LAQVNAMLREQLD---QAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAY 288
Query: 865 IHRLEADMALAKEE--SEKAAESRIKRLRDKYEAEL-SELEQSERKLQERCSELKGQLGE 921
+ + L + + S +K ++ +L EL ++ R +QE L L
Sbjct: 289 FSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRL 348
Query: 922 AEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKA 981
AE + +++AL AQ + EQL + + +Q+ + L ++ R +
Sbjct: 349 AES-----RAEAALEKQALLQAQ-LEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTEL 402
Query: 982 ELATLQ-ARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRAD 1027
LA + +Q LE ++V++ L K EA+ SLR Q +AA++ D
Sbjct: 403 GLAVKRLEKQNLEKDQVNK----DLTEKLEALESLRLQEQAALETED 445
Score = 52.0 bits (123), Expect = 3e-06
Identities = 121/547 (22%), Positives = 218/547 (39%), Gaps = 76/547 (13%)
Query: 227 GKLPKNVSSATHSARNNTGGSTGLPRRKEVTEE--EAERFIHQVNQATVTIQRWYRHQVQ 284
G P + AT A + +E +E A+R ++ T + R
Sbjct: 1485 GSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEA 1544
Query: 285 RRGAGAARLEHLLQAKRE-EQRQRSGEGTL----LDLHQQKEAARRKAREEKARQARRAA 339
R + +R L +A E E+ +RS +G L +L Q+E+ RR RE +A + A
Sbjct: 1545 ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVAT 1604
Query: 340 IQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQE-LSPTPGGTAHQALKANNTG 398
++ Q A ++ ++ E+ ET++ G ++ +E L + T L+ +
Sbjct: 1605 LERSLQ--ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 399 GGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQ-DAAGDNLEMMAPSRGSA-----K 452
G L + G L ++ + Q D Q +A + L++ A +
Sbjct: 1663 GELQRSRLG---LSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE 1719
Query: 453 SRGPLEELLHTL-QLLEKEPDVL--PRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLS 509
S G L + + L + L + L R + H + A E D + + L+
Sbjct: 1720 SEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHD--RQVLQERLD--AARQ 1775
Query: 510 AFPEPPEDGTLLSEAKLQSIMSF-----LDEMEKSGQDQ-----LDSQQEGWVPEAGPGP 559
A E + + L E ++Q++ L +E GQ Q L +QEG
Sbjct: 1776 ALSEARKQSSSLGE-QVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEG--------- 1825
Query: 560 LELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQ------QRDLTARRVKETEKALSRQL 613
+ +V +L+ E ++ + LQRALAQ + + +A R+++ AL R L
Sbjct: 1826 ---EAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTL 1882
Query: 614 -----QRQREHYEAT--------IQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT 660
++ R H + + R L + + + + ++ EA V L+Q
Sbjct: 1883 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ 1942
Query: 661 ERVAQAQAQHEL--EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIAR 718
V Q Q EL E+++L+ + TE+ E ++ VRGLE ++ L +
Sbjct: 1943 LEVDAQQQQLELQQEVERLRSAQAQTERTL------EARERAHRQRVRGLEEQVSTLKGQ 1996
Query: 719 HKQEVRR 725
+QE+RR
Sbjct: 1997 LQQELRR 2003
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 101 bits (252), Expect = 3e-21
Identities = 120/507 (23%), Positives = 242/507 (47%), Gaps = 67/507 (13%)
Query: 552 VPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQ---QRDLTARRVK----- 603
V E E+ +E++ +L+ E E K+ + L+ LA+ ++ T +VK
Sbjct: 926 VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 604 -----ETEKALSRQLQRQREHYEATI---QRHLAFIDQLIEDKKVLSEKCEAVVAELKQE 655
ET L+++ + +E ++ T+ Q ++ L + K L ++ + + L+QE
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE 1045
Query: 656 DQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKL 715
+ C + + +A+ + E ++K +E TE +++ ++EK KK KE + L+ +I+
Sbjct: 1046 KKLCMD-LERAKRKLEGDLKLAQESTMDTENDKQQ--LNEKLKK-KEFEMSNLQGKIEDE 1101
Query: 716 IARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQ 775
A Q +++K L + EEL E++E E+ + + E++R+ +
Sbjct: 1102 QALAIQLQKKIKELQA----------------RIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 776 RAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRT 835
ELEE+ ++LEE+ A + + ++ E Q+ R +E +TL+ + + +
Sbjct: 1146 --ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADS 1203
Query: 836 RKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYE 895
E ++ Q +++++ K + E+++ I+ L ++M E+ A++ +++ E
Sbjct: 1204 VAELGEQIDSLQRVKQKLEKEK-SELKMEINDLASNM-----ETVSKAKANFEKMCRTLE 1257
Query: 896 AELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERS 955
+LSE++ E + Q +EL Q RL + R L++ A+ QLS +
Sbjct: 1258 DQLSEIKTKEEEQQRLINELSAQ-------KARLHTESGEFSRQLDEKDAMVSQLSRGK- 1309
Query: 956 NLAQVIRQEFEDRLAASEEETRQAKAELA-TLQA--------RQQLELE-EVHRRVKTAL 1005
Q Q+ E+ EEET+ AK+ LA LQ+ R+Q E E E ++ +
Sbjct: 1310 ---QAFTQQIEELKRQLEEETK-AKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 1006 ARKEEAVSSLRTQHEA-AVKRADHLEE 1031
++ V+ RT++E A++R + LEE
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEE 1392
Score = 94.7 bits (234), Expect = 4e-19
Identities = 106/480 (22%), Positives = 219/480 (45%), Gaps = 34/480 (7%)
Query: 574 KLEVEEKKQAMLLLQRA-LAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFID 632
++E E +A QR+ L+++ + + R++E A S Q++ ++ EA Q+ ++
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR-EAEFQKMRRDLE 1183
Query: 633 QLIEDKKV----LSEKCEAVVAELKQED---QRCTERVAQAQAQHELEIKKLKELMSATE 685
+ + L +K VAEL ++ QR +++ + +++ ++EI L M
Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVS 1243
Query: 686 KARR--EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRL--------KSLHEAELL 735
KA+ EK ++ E+ + E E Q+LI + RL + L E + +
Sbjct: 1244 KAKANFEKMCRTLEDQLSEIKTK--EEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 736 QSD-ERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALT 794
S R Q +Q EEL+ QLE E +A + A Q R + + LR+Q EE A
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKA--KSTLAHALQSARHDCDLLREQYEEEQEAKA 1359
Query: 795 RALRAEFEKGREEQERRHQMELNTLKQQLELE---RQAWEAGRTRKEEAWLLNREQELRE 851
R + E + R + E + +++ ELE ++ + + +E +N + E
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419
Query: 852 EIRKGRDKEIELVIHRLEADMA--LAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQ 909
+ ++ E+E ++ +E A +A ++ ++ + + + KYE +ELE S+++ +
Sbjct: 1420 KTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESR 1479
Query: 910 ERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQV--IRQEFED 967
+EL E L+ L R+ + ++ + EQ++ ++ ++ ++++ +
Sbjct: 1480 SLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDH 1539
Query: 968 RLAASEEETRQAKAELATLQA---RQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVK 1024
+ + +A+A L + R QLEL +V + +A K+E + L+ H V+
Sbjct: 1540 EKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVE 1599
Score = 70.1 bits (170), Expect = 1e-11
Identities = 104/400 (26%), Positives = 169/400 (42%), Gaps = 68/400 (17%)
Query: 676 KLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ-EVRRLKSLHEAEL 734
K+K L+ + E + + E+ +K KE E+ K A+ K+ E + + + E
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKE--------ELAKTEAKRKELEEKMVTLMQEKND 890
Query: 735 LQSDERASQRCLRQAEELREQLEREK---EALGQQERERARQRQR--AELEELRQQLEES 789
LQ +A L AEE +QL + K EA ++ ERA + AEL +++LE+
Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 790 SSALTRALR-AEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
S L + + E + E+E+ H E E+ + KE+ L Q+
Sbjct: 951 CSELKKDIDDLELTLAKVEKEK-HATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 849 LREEIRKGRDK---------EIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELS 899
++++ DK ++E + LE + E EK ++R + K E +L
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSL-----EQEKKLCMDLERAKRKLEGDLK 1064
Query: 900 ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQ 959
++S + +L +L + E E LQG + ED QA+ QL + L
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI-------EDEQALAIQLQKKIKELQA 1117
Query: 960 VIRQEFEDRLAASEEETRQAKAELATLQARQQL--ELEEVHRRVKTA---------LARK 1008
I +E E+ + A E +AKAE + R L ELEE+ R++ A + +K
Sbjct: 1118 RI-EELEEEIEA--ERASRAKAE----KQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1170
Query: 1009 EEA--------VSSLRTQHEAAV-----KRADHLEELLEQ 1035
EA + QHEA K AD + EL EQ
Sbjct: 1171 REAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQ 1210
Score = 66.6 bits (161), Expect = 1e-10
Identities = 100/478 (20%), Positives = 204/478 (42%), Gaps = 65/478 (13%)
Query: 566 VSTSVMRLKLEVEEKKQAMLLLQRA---LAQQ-RDLT------ARRVKETEKALSRQLQR 615
+ST + ++K EE + L+R L Q+ DLT + + E EK + +QL
Sbjct: 1481 LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEK-VKKQLDH 1539
Query: 616 QREHYEATIQRHLAFIDQLIEDKKVLSEKCEA--VVAELKQEDQRCTERVAQAQAQHELE 673
++ + +++ A ++ E+ K+L + E V +E+ ++ E + Q + H
Sbjct: 1540 EKSELQTSLEEAEASLEH--EEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRV 1597
Query: 674 IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKS----L 729
++ ++ + A ++R + + + KK E + +E ++ + + +R L++ L
Sbjct: 1598 VESMQSTLDAEIRSRND---ALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGIL 1654
Query: 730 HEAELLQSD---------------ERASQRCLRQAEELREQLER--------EKEALGQQ 766
+ +L D ER + + EELR LER E+E L
Sbjct: 1655 KDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDAS 1714
Query: 767 ERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE 826
ER + Q L +++LE S + + ++ R +E+ + + EL+
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 827 RQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESR 886
+ E + E N EQ + K+++L + E ++ + E+R
Sbjct: 1775 K---EQDTSAHLERMKKNMEQTV---------KDLQLRLDEAEQLALKGGKKQIQKLEAR 1822
Query: 887 IKRLRDKYEAELS---ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDA 943
++ L + E+E E + RK + R EL Q E LRLQ LV + + ++
Sbjct: 1823 VRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY 1882
Query: 944 QAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRV 1001
+ E+ + E+SN+ ++ + L ++E A++++ L+ + + EVH +V
Sbjct: 1883 KRQAEE-AEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSR----EVHTKV 1935
Score = 51.2 bits (121), Expect = 5e-06
Identities = 68/302 (22%), Positives = 126/302 (41%), Gaps = 73/302 (24%)
Query: 779 LEELRQ----QLEESSSALTRA--LRAEFEKGREEQERRHQMELNTLKQQLELERQAW-- 830
LEE+R QL + A+ R +R EF K E +E ++ N ++ + ++ W
Sbjct: 777 LEEMRDEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQYN-IRAFMNVKHWPWMK 835
Query: 831 ---------EAGRTRKEEAWLLNREQELREEIRKGRDKEIEL---------------VIH 866
++ T KE A + ++ +EE+ K K EL +
Sbjct: 836 LYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895
Query: 867 RLEADMALAKEE-------SEKAAESRIKRLRDKYEAEL---SELEQSERKLQERCSELK 916
+ EAD EE ++ E++IK + ++ E E +EL +RKL++ CSELK
Sbjct: 896 QAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955
Query: 917 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 976
+ + E L L + ++K + + E+++ +A++ T
Sbjct: 956 KDIDDLE---LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL---------------T 997
Query: 977 RQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQH 1036
++ KA L+E H++ L +E+ V++L ++ D LE LEQ
Sbjct: 998 KEKKA------------LQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE 1045
Query: 1037 RR 1038
++
Sbjct: 1046 KK 1047
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 100 bits (249), Expect = 7e-21
Identities = 172/721 (23%), Positives = 309/721 (42%), Gaps = 100/721 (13%)
Query: 293 LEHLLQAKR---EEQRQRSGEGTLLDLHQQKEAARRKAREEKARQARRAAIQELQQKRAL 349
LE +L+ K+ E+ R R E T L ++E A R E RQ + ++L+
Sbjct: 476 LEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLR----- 530
Query: 350 RAQKASTAERGPPENPRETRVPGMRQPAQELSPTPGGTAH-QALKANNTGGGLPAAGPGD 408
R+ + +T + E R+ +R +EL T T H Q++ N
Sbjct: 531 RSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNK----------- 579
Query: 409 RCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNLEMMAPSRGSAK-SRGPLEELLHTLQLL 467
D Q+ + R + ++ G+ +E++ A+ S G ++ ++L
Sbjct: 580 -----EDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQV----EVL 630
Query: 468 EKEPDVLPRPRTHHRGRYAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQ 527
+KE L R + + A ++ A LEK +L+ + G L E LQ
Sbjct: 631 KKE---LLRTQEELKELQAERQSQEVAGRHRDRELEK--QLAVLRVEADRGRELEEQNLQ 685
Query: 528 SIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPL-ELGSEVSTSVMRLKLEVEEKKQAMLL 586
+++ QD ++ + V EA L + + V T++ + E +E ++ +L
Sbjct: 686 ----LQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILG 741
Query: 587 LQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCE 646
L++ L + R L + +A+ +L+ + + EA Q+ ++ E++ L+
Sbjct: 742 LEQQLKETRGLV-----DGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKR 796
Query: 647 AVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVR 706
A+ A L +E QR R+ Q Q + L+E E RR K E+ K++ + TV
Sbjct: 797 ALEARL-EEAQRGLARLGQEQQTLN---RALEEEGKQREVLRRGKAELEEQKRLLDRTVD 852
Query: 707 GLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEE--------------L 752
L E++K+ KQ +++L++ E + + R RQA++ L
Sbjct: 853 RLNKELEKIGEDSKQALQQLQAQLE-DYKEKARREVADAQRQAKDWASEAEKTSGGLSRL 911
Query: 753 REQLEREKEALGQQERERARQRQRAELEELRQQ-LEESSSALTRAL--RAEFEKGREEQE 809
+++++R ++AL + ER R EL R Q LE+ + R+ RA KG EE+
Sbjct: 912 QDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKV 971
Query: 810 RRHQMELNTLKQQLELERQAWEAGRTRKEEAWL-LNREQELREEI--------RKGRDKE 860
R + EL+ K +EL GR + ++ L +E+ R+++ R+ +D +
Sbjct: 972 SRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLK 1031
Query: 861 IELV-----------IHRLEADMALAKE-----ESEKAA--------ESRIKRLRDKYEA 896
L + +LE+ L +E E EK E ++K L + E
Sbjct: 1032 TRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIED 1091
Query: 897 ELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSN 956
E + + +L R LK Q+ EAE E RL GL ++ +R +E+ VNEQL + +
Sbjct: 1092 ERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151
Query: 957 L 957
L
Sbjct: 1152 L 1152
Score = 93.6 bits (231), Expect = 9e-19
Identities = 127/500 (25%), Positives = 217/500 (43%), Gaps = 71/500 (14%)
Query: 577 VEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEATIQRHLAFIDQLIE 636
+E ++Q M L R L ++ + T+ + Q+ +E AT Q L + E
Sbjct: 543 LEAERQKMSALVRGLQRELEETSEETGHWQS----MFQKNKEDLRATKQELLQLRMEKEE 598
Query: 637 DKKVLSEKCEAVVAELKQE-----DQRCTERVAQAQAQHELEIKKLKELMSATEKA--RR 689
++ L EK E + EL+Q D R E + + + + E+K+L+ + E A R
Sbjct: 599 MEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHR 658
Query: 690 EKWISEKTKKIKEVTVRGLEPEIQKL--------IARHKQEVRRLKSLHEAELLQSDER- 740
++ + ++ ++ RG E E Q L + + +E + K + EAE +R
Sbjct: 659 DRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRR 718
Query: 741 -ASQRCLRQAEELREQLEREKEALGQQERE-----------RARQRQRAE-LEELRQQLE 787
A + LR+ +E ++ R L QQ +E AR R + + LE +QQLE
Sbjct: 719 AAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLE 778
Query: 788 E----------SSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRK 837
E S +A RAL A E+ + R Q E TL + LE E G+ R+
Sbjct: 779 EALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQ-EQQTLNRALE------EEGKQRE 831
Query: 838 EEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAE 897
+L R + EE ++ D+ ++ RL ++ E+S++A + +L D E
Sbjct: 832 ----VLRRGKAELEEQKRLLDRTVD----RLNKELEKIGEDSKQALQQLQAQLEDYKEKA 883
Query: 898 LSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNL 957
E+ ++R+ ++ SE + + G RLQ +++ +AL+ +QA + ++ L
Sbjct: 884 RREVADAQRQAKDWASEAE----KTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELL 939
Query: 958 AQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRT 1017
AQ RL E+E K +ARQ LEE R++T L ++ V L
Sbjct: 940 AQ--------RLQGLEQEAENKKRSQDD-RARQLKGLEEKVSRLETELDEEKNTVELLTD 990
Query: 1018 QHEAAVKRADHLEELLEQHR 1037
+ + D L L Q R
Sbjct: 991 RVNRGRDQVDQLRTELMQER 1010
Score = 68.2 bits (165), Expect = 4e-11
Identities = 134/616 (21%), Positives = 245/616 (39%), Gaps = 66/616 (10%)
Query: 247 STGLPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQ 306
S G R+ EV ++E R ++ + Q +V R + L + E R
Sbjct: 620 SAGDTRQVEVLKKELLRTQEELKELQAERQS---QEVAGRHRDRELEKQLAVLRVEADRG 676
Query: 307 RSGEGTLLDLHQQKEAARRKARE-EKARQARRAAIQELQQKRALRAQKASTAERGPPENP 365
R E L L + + R+ E KA+ A L Q+RA A + + E +
Sbjct: 677 RELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRA--AVETTLRETQEENDE 734
Query: 366 RETRVPGMRQPAQELSP-TPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPP 424
R+ G+ Q +E GG A +A + + L E
Sbjct: 735 FRRRILGLEQQLKETRGLVDGGEAVEARLRDKL-----------QRLEAEKQQLEEALNA 783
Query: 425 EDRTQDVLAQDAAGDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGR 484
+ LA + RG A+ + L L+ K+ +VL R +
Sbjct: 784 SQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGK------ 837
Query: 485 YAWASEEDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQL 544
A E+ T D L K +L E + +A+L+ D EK+ ++
Sbjct: 838 -AELEEQKRLLDRTVDRLNK--ELEKIGEDSKQALQQLQAQLE------DYKEKARREVA 888
Query: 545 DSQQEG--WVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQ--RALAQ-QRDLTA 599
D+Q++ W EA + S + RL+ E++ +QA+ Q R A+ ++L A
Sbjct: 889 DAQRQAKDWASEA--------EKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLA 940
Query: 600 RRVK--ETEKALSRQLQRQREHYEATIQRHLAFID-QLIEDKKVLSEKCEAVVAELKQED 656
+R++ E E ++ Q R ++ ++ ++ +L E+K + + V Q D
Sbjct: 941 QRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVD 1000
Query: 657 QRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLI 716
Q TE + + A+ +LE K+ + K + + S + + ++ LE + Q L
Sbjct: 1001 QLRTELMQERSARQDLECDKIS--LERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQ 1058
Query: 717 ARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQR 776
R + E R E +LQS R +R + +EL Q+E E++ + Q+ + + +
Sbjct: 1059 ERLQAEER------EKTVLQSTNRKLER---KVKELSIQIEDERQHVNDQKDQLSLR--- 1106
Query: 777 AELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTR 836
++ L++Q++E+ + R L +K + E E +H++ + LE+ +W
Sbjct: 1107 --VKALKRQVDEAEEEIER-LDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRS 1163
Query: 837 KEEAWLLNREQELREE 852
E+ L N EE
Sbjct: 1164 AAESALKNEGLSSDEE 1179
Score = 58.2 bits (139), Expect = 4e-08
Identities = 73/308 (23%), Positives = 145/308 (47%), Gaps = 34/308 (11%)
Query: 743 QRCLRQAEELREQLEREKEALGQQERERARQRQRA-ELEELRQQLEESSSALTRALRAEF 801
QR L + + R++LE + L +Q E+ + R EL E R+ + S+ + ++
Sbjct: 372 QRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLL 431
Query: 802 EKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWL--LNREQELREEIRKGRDK 859
++G ++ RH +E ++ Q +L+ G +E L L +EL EE+ +G+ +
Sbjct: 432 DQG---EDLRHGLETQVMELQNKLKH---VQGPEPAKEVLLKDLLETRELLEEVLEGKQR 485
Query: 860 EIELVIHRLEADMAL--AKEESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKG 917
E + R AL A +E + + ++ +R +Y+ + +L +S + + + L
Sbjct: 486 VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVL-- 543
Query: 918 QLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETR 977
E E ++ LVR +R LE+ +SE + Q + Q+ ++ L A+++E
Sbjct: 544 -----EAERQKMSALVRGLQRELEE--------TSEETGHWQSMFQKNKEDLRATKQELL 590
Query: 978 QAKAELATLQARQQLELEEVHRRVKTALA-----RKEEAVSS--LRTQHEAAVKRAD-HL 1029
Q + E ++ ++E + R ++ A A R+ E + LRTQ E +A+
Sbjct: 591 QLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQS 650
Query: 1030 EELLEQHR 1037
+E+ +HR
Sbjct: 651 QEVAGRHR 658
Score = 55.1 bits (131), Expect = 3e-07
Identities = 81/319 (25%), Positives = 139/319 (43%), Gaps = 48/319 (15%)
Query: 764 GQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGR----------EEQERRHQ 813
G E E + +R+ + + E Q L SS T+A+ + E R EE ++R +
Sbjct: 325 GSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQK 384
Query: 814 MELNTLKQQLELERQAWEAGR------TRKEEAWLLNRE-QELREEIRKGRDKEIELVIH 866
+E + + + +LE + E R RK EA N+E Q ++ + +G D L
Sbjct: 385 LEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQ 444
Query: 867 RLEADMALAKEES-EKAAESRIKRLRDKYEAELSELEQSER-----KLQER-CSELKGQL 919
+E L + E A E +K L + E LE +R +L+ER + LKG L
Sbjct: 445 VMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGAL 504
Query: 920 GE------AEGENLR--LQGLVRQKERALEDAQAVNEQLSSERSNLAQVIR---QEFED- 967
E E E++R Q Q R+++DA + L +ER ++ ++R +E E+
Sbjct: 505 KEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEET 564
Query: 968 ---------RLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQ 1018
++E+ R K EL L+ ++ EE+ +++ E+A +S
Sbjct: 565 SEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDT 624
Query: 1019 HEAAVKRADHL---EELLE 1034
+ V + + L EEL E
Sbjct: 625 RQVEVLKKELLRTQEELKE 643
Score = 40.8 bits (94), Expect = 0.007
Identities = 93/495 (18%), Positives = 182/495 (36%), Gaps = 82/495 (16%)
Query: 234 SSATHSARNNTGGSTGLPRRKEVTEEEAERFIHQVNQATVT---------IQRWYRHQVQ 284
+ AT + T L +E +E R + Q T ++ R ++Q
Sbjct: 709 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQ 768
Query: 285 RRGAGAARLEHLLQAKREEQ------------RQRSGEGTLLDLHQQKEAARRKAREE-K 331
R A +LE L A +EE+ R + L L Q+++ R EE K
Sbjct: 769 RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGK 828
Query: 332 ARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQ----------ELS 381
R+ R EL++++ L + + + +++ + AQ E++
Sbjct: 829 QREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVA 888
Query: 382 PTPGGTAHQALKANNTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAAGDNL 441
A +A T GGL + L + + + ++ +++LAQ G
Sbjct: 889 DAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQ 948
Query: 442 EMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASSLTADN 501
E R L+ L + LE E D EE + L D
Sbjct: 949 EAENKKRSQDDRARQLKGLEEKVSRLETELD-----------------EEKNTVELLTDR 991
Query: 502 L----EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGP 557
+ ++ +L E ++ + + + I L+ K + +L S + P A
Sbjct: 992 VNRGRDQVDQLRT--ELMQERSARQDLECDKIS--LERQNKDLKTRLASSEGFQKPSASL 1047
Query: 558 GPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQR 617
LE ++ +++ +L+ EE+++ +L T R+++ K LS Q++ +R
Sbjct: 1048 SQLESQNQ----LLQERLQAEEREKTVL----------QSTNRKLERKVKELSIQIEDER 1093
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKL 677
+H DQL K L + + E+++ D + + + QHE+
Sbjct: 1094 QHVNDQ-------KDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVN---- 1142
Query: 678 KELMSATEKARREKW 692
++L + + ++ W
Sbjct: 1143 EQLQARIKSLEKDSW 1157
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 99.8 bits (247), Expect = 1e-20
Identities = 130/558 (23%), Positives = 253/558 (45%), Gaps = 52/558 (9%)
Query: 503 EKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEKSGQDQLDS--QQEGWVPEAGPGPL 560
E+F +L E E E K+ S++ ++++ Q + D+ E + +
Sbjct: 854 EEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Query: 561 ELGSEVSTSVMRLKLEVEEKKQAMLLLQ-RALAQQRDLTARRVKETEKALSRQLQRQR-- 617
+L ++V M +LE EE+ A L + R L + R + + E L++ + +
Sbjct: 914 QLEAKVKE--MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHAT 971
Query: 618 EHYEATIQRHLAFIDQLI----EDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELE 673
E+ + +A +D++I ++KK L E + + +L+ E+ + + +A+ + E +
Sbjct: 972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK-VNTLTKAKVKLEQQ 1030
Query: 674 IKKLKELMSATEKAR----REKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL 729
+ L+ + +K R R K E K+ + ++ LE + Q+L R K++ L +L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 730 H-----EAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQ 784
+ E L ++ + + EEL E+LE E+ A + E+ R+ + ELEE+ +
Sbjct: 1091 NARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR--ELEEISE 1148
Query: 785 QLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLN 844
+LEE+ A + + ++ E Q+ R +E TL+ + A RK+ A +
Sbjct: 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA-------TAAALRKKHADSVA 1201
Query: 845 REQELREEIRKGRDK-EIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQ 903
E + +++ + K E E +LE D + E A++ ++++ E +++E
Sbjct: 1202 ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRS 1261
Query: 904 SERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQ 963
+ Q ++L Q + + EN L R L++ +A+ QL+ R L Q
Sbjct: 1262 KAEETQRSVNDLTSQRAKLQTENGEL-------SRQLDEKEALISQLT--RGKLTYT--Q 1310
Query: 964 EFEDRLAASEEETRQAKAELATLQA--------RQQLELE-EVHRRVKTALARKEEAVSS 1014
+ ED EEE + A LQ+ R+Q E E E ++ L++ V+
Sbjct: 1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1370
Query: 1015 LRTQHEA-AVKRADHLEE 1031
RT++E A++R + LEE
Sbjct: 1371 WRTKYETDAIQRTEELEE 1388
Score = 94.0 bits (232), Expect = 7e-19
Identities = 174/818 (21%), Positives = 337/818 (41%), Gaps = 94/818 (11%)
Query: 260 EAERFIHQVNQATVTIQRWYRHQVQRRGAGAARLEHLLQAKREEQRQRSGEGTLLDLHQQ 319
E E+ + + + ++ RR ++ LLQ K + Q Q E L
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL----- 898
Query: 320 KEAARRKAREEKARQARRAAIQELQQKRALRAQKASTAERGPPENPRETRVPGMRQPAQE 379
+A R + K + A ++E+ ++ L ++ AE + E +++ +
Sbjct: 899 ADAEERCDQLIKNKIQLEAKVKEMNER--LEDEEEMNAELTAKKRKLEDECSELKRDIDD 956
Query: 380 LSPTPGGTAHQALKANNTGGGLPA--AGPGDRCLPTSDSSPEPQQPPEDRTQDVLAQDAA 437
L T + N L AG + + Q+ + D+ A++
Sbjct: 957 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016
Query: 438 GDNLEMMAPSRGSAKSRGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASE-----ED 492
+ L ++ K +++L +L+ +K L R + G E E+
Sbjct: 1017 VNTL-----TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1071
Query: 493 DASSLTADNLEKFGKLSAFPEPPEDGTLLS---EAKLQSIMSFLDEMEKSGQDQLDSQQE 549
D L +K +L+A ED L + KL+ + + ++E+E ++L++++
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELE----EELEAERT 1127
Query: 550 GWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKAL 609
++V L E+EE + + A + Q ++ +R E +K +
Sbjct: 1128 A------------RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK-M 1174
Query: 610 SRQLQRQREHYEATI----QRH---LAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCT-- 660
R L+ +EAT ++H +A + + I++ + + +K E +E K E T
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1234
Query: 661 -ERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARH 719
E++ +A+A E + L++ M+ R K +E+T++ +V L + KL +
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNE----HRSK--AEETQR----SVNDLTSQRAKLQTEN 1284
Query: 720 KQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAEL 779
+ R+L + L+ R +Q E+L+ QLE E +A + A Q R +
Sbjct: 1285 GELSRQLDE--KEALISQLTRGKLTYTQQLEDLKRQLEEEVKA--KNALAHALQSARHDC 1340
Query: 780 EELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEE 839
+ LR+Q EE + A R + E + R + E + +++ ELE +K+
Sbjct: 1341 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE-------AKKKL 1393
Query: 840 AWLLNREQELREEIRKGRDKEIELVIHRLE---ADMALAKEESEKAAESRIKRLRD---- 892
A L +E E + + +E HRL+ D+ + E S AA + K+ R+
Sbjct: 1394 AQRLQEAEEAVEAVN-AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 893 ------KYEAELSELEQSERKLQERCSELKGQLGEAEGENL-RLQGLVRQKERALEDAQA 945
KYE SELE S+++ + +EL +L A E+L L+ R+ + E+
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTEL-FKLKNAYEESLEHLETFKRENKNLQEEISD 1511
Query: 946 VNEQLSSERSNLAQV--IRQEFEDRLAASEEETRQAKAELATLQA---RQQLELEEVHRR 1000
+ EQL S + ++ +R++ E + +A+A L + R QLE ++
Sbjct: 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1571
Query: 1001 VKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQHRR 1038
++ LA K+E + + H ++ D L+ L+ R
Sbjct: 1572 IERKLAEKDEEMEQAKRNH---LRVVDSLQTSLDAETR 1606
Score = 87.0 bits (214), Expect = 8e-17
Identities = 125/515 (24%), Positives = 232/515 (45%), Gaps = 77/515 (14%)
Query: 543 QLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRA------LAQQRD 596
QLD ++E + + G L ++ +L+ EV+ K LQ A L +Q +
Sbjct: 1290 QLD-EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYE 1348
Query: 597 LTARRVKETEKALSR---QLQRQREHYEA-TIQRHLAFIDQLIEDKKVLSEKCEAVVAEL 652
E ++ LS+ ++ + R YE IQR ++L E KK L+++ + +
Sbjct: 1349 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQR----TEELEEAKKKLAQRLQEAEEAV 1404
Query: 653 KQEDQRCTE-RVAQAQAQHELE-----IKKLKELMSATEKARR--EKWISEKTKKIKEVT 704
+ + +C+ + + Q+E+E +++ +A +K +R +K ++E +K +E +
Sbjct: 1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE-S 1463
Query: 705 VRGLEPEIQKLIARHKQEVRRLKSLHEAEL--LQSDERASQRCLRQAEELREQLEREKEA 762
LE QK E+ +LK+ +E L L++ +R ++ + +L EQL +
Sbjct: 1464 QSELESS-QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKT 1522
Query: 763 LGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQ 822
+ E E+ R++ AE EL+ LEE+ ++L E E+G+ R Q+E N +K
Sbjct: 1523 I--HELEKVRKQLEAEKMELQSALEEAEASL------EHEEGKI---LRAQLEFNQIKA- 1570
Query: 823 LELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKA 882
E+ER+ E K+E EQ R +R V+ L+ + ++E
Sbjct: 1571 -EIERKLAE-----KDE----EMEQAKRNHLR---------VVDSLQTSL-----DAETR 1606
Query: 883 AESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALED 942
+ + R++ K E +L+E+E + S EA+ + LQ L++ + L+D
Sbjct: 1607 SRNEALRVKKKMEGDLNEMEI-------QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
Query: 943 AQAVNEQLS------SERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEE 996
A N+ L R+NL Q +E + +E + A+ EL R QL L
Sbjct: 1660 AVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQL-LHS 1718
Query: 997 VHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEE 1031
+ + + + +S L+T+ E AV+ + EE
Sbjct: 1719 QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
Score = 77.0 bits (188), Expect = 8e-14
Identities = 100/467 (21%), Positives = 202/467 (43%), Gaps = 70/467 (14%)
Query: 566 VSTSVMRLKLEVEEKKQAMLLLQRA----------LAQQRDLTARRVKETEKALSRQLQR 615
+ST + +LK EE + + +R L +Q + + + E EK + +QL+
Sbjct: 1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEK-VRKQLEA 1535
Query: 616 QREHYEATIQRHLAFIDQLIEDKKVLSEKCE--AVVAELKQEDQRCTERVAQAQAQHELE 673
++ ++ ++ A ++ E+ K+L + E + AE++++ E + QA+ H
Sbjct: 1536 EKMELQSALEEAEASLEH--EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRV 1593
Query: 674 IKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQ---KLIARHKQEVRRLKSLH 730
+ L+ + A ++R E + + KK E + +E ++ ++ A +++V+ L+SL
Sbjct: 1594 VDSLQTSLDAETRSRNE---ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1650
Query: 731 EAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESS 790
+ +Q D+ +R ++L+E + ER +AELEELR +E++
Sbjct: 1651 KDTQIQLDD-----AVRANDDLKENIAIV---------ERRNNLLQAELEELRAVVEQTE 1696
Query: 791 SALTRALRAEFEKGREEQ----------ERRHQMELNTLKQQLELERQAWEAGRTRKEEA 840
+ A + E Q ++ +M+ + + Q E+E E ++
Sbjct: 1697 RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAK 1756
Query: 841 WLLNREQELREEIRKGRDKEIELV-----IHRLEADMALAKEESEKAAESRIKRLRDKYE 895
+ + EE++K +D L + + D+ +E+E+ A K+ K E
Sbjct: 1757 KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLE 1816
Query: 896 AELSELE--------------QSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALE 941
A + ELE + RK + R EL Q E LRLQ LV + + ++
Sbjct: 1817 ARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK 1876
Query: 942 ----DAQAVNEQLSSERSNLAQVIRQ--EFEDRLAASEEETRQAKAE 982
A+ EQ ++ S +V + E E+R +E + + +A+
Sbjct: 1877 AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/332 (25%), Positives = 150/332 (45%), Gaps = 48/332 (14%)
Query: 734 LLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSAL 793
LL+S ER ++ ++E+ R KEAL E+ AR R ELEE L + + L
Sbjct: 839 LLKSAERE-----KEMASMKEEFTRLKEAL---EKSEAR---RKELEEKMVSLLQEKNDL 887
Query: 794 TRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEI 853
++AE + + +ER Q+ +K +++LE + E ++E EL +
Sbjct: 888 QLQVQAEQDNLADAEERCDQL----IKNKIQLEAKVKEMNERLEDEE---EMNAELTAKK 940
Query: 854 RKGRDKEIELVIHRLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQ 909
RK D+ EL + ++ LAK E EK A E+++K L ++ + +++L + ++ LQ
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 910 ERCSELKGQLGEAEGENLRLQGLVRQK---ERALEDAQAVNEQLSSERSNLAQVIRQ--- 963
E + L + + E ++ L + K E+ ++D + EQ R +L + R+
Sbjct: 1001 EAHQQ---ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1057
Query: 964 ----------EFEDRLAASEEETRQAKAELATLQAR---QQLELEEVHRRVKTALARKEE 1010
+ E+ +E ++ EL L AR +Q ++ +++K AR EE
Sbjct: 1058 DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEE 1117
Query: 1011 AVSSLRTQHEAAVK----RADHLEELLEQHRR 1038
L + A K R+D EL E R
Sbjct: 1118 LEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Score = 38.5 bits (88), Expect = 0.033
Identities = 55/260 (21%), Positives = 115/260 (44%), Gaps = 24/260 (9%)
Query: 521 LSEAKLQSIMSFLDEMEKSG----QDQLD-SQQEGWVPEAGPGPLELGSEVSTSVMRLKL 575
L +A+L+ + + +++ E+S Q+ ++ S++ + + ++ + +L+
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739
Query: 576 EVEEKKQAMLLLQRALAQQRDLTARRVKETEKA--LSRQLQRQREHYEATI---QRHLAF 630
EVEE Q + + A +E +K S L+R +++ E TI Q L
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 631 IDQL-IEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARR 689
+Q+ ++ K +K EA V EL+ E + +R A++ +++KEL TE+ R+
Sbjct: 1800 AEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRK 1859
Query: 690 EKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQA 749
+ ++ L ++Q + +K++ + +A S R Q L +A
Sbjct: 1860 NL-----------LRLQDLVDKLQLKVKAYKRQAEEAE--EQANTNLSKFRKVQHELDEA 1906
Query: 750 EELREQLEREKEALGQQERE 769
EE + E + L + R+
Sbjct: 1907 EERADIAESQVNKLRAKSRD 1926
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 99.4 bits (246), Expect = 2e-20
Identities = 125/563 (22%), Positives = 255/563 (45%), Gaps = 56/563 (9%)
Query: 491 EDDASSLTADNLEKFGKLSAFPEPPEDGTLLSEAKLQSIMSFLDEMEK--SGQDQLDSQQ 548
+D+ + A E KL + D L +A+ ++++ + ++ + QL+++
Sbjct: 861 KDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Query: 549 EGWVPEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKA 608
+ V E E+ +E++ +L+ E E K+ + +LT +V++ + A
Sbjct: 921 KE-VTERAEDEEEINAELTAKKRKLEDECSELKKDI--------DDLELTLAKVEKEKHA 971
Query: 609 LSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQA 668
+++ E + I +L +KK L E + + +L+ E+ + + + ++
Sbjct: 972 TENKVKNLTEELSGLDET----IAKLTREKKALQEAHQQALDDLQAEEDKVNS-LNKTKS 1026
Query: 669 QHELEIKKLKELMSATEKAR----REKWISEKTKKIKEVTVRGLEPEIQKLIARHKQ--- 721
+ E +++ L+ + +K R R K E K+ + ++ LE + Q+L R K+
Sbjct: 1027 KLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDF 1086
Query: 722 EVRRLKSLHEAEL---LQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAE 778
E +L+S E E LQ ++ + R EEL E++E E+ + E++R+ + E
Sbjct: 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQAR-IEELEEEIEAERATRAKTEKQRSDYAR--E 1143
Query: 779 LEELRQQLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKE 838
LEEL ++LEE+ + + ++ E + R +E TL+ + + + + E
Sbjct: 1144 LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE 1203
Query: 839 EAWLLNREQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAEL 898
++ Q +++++ K + + +LE D + ES +++ ++++ E +L
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSE------FKLEIDDLSSSMESVSKSKANLEKICRTLEDQL 1257
Query: 899 SELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLA 958
SE ++Q SEL Q RLQ + R LE+ +++ QLS +
Sbjct: 1258 SEARGKNEEIQRSLSELTTQ-------KSRLQTEAGELSRQLEEKESIVSQLSRSK---- 1306
Query: 959 QVIRQEFEDRLAASEEETRQAKAELATLQA--------RQQLELE-EVHRRVKTALARKE 1009
Q Q+ E+ EEE + A LQ+ R+Q E E E ++ AL++
Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1366
Query: 1010 EAVSSLRTQHEA-AVKRADHLEE 1031
V+ RT++E A++R + LEE
Sbjct: 1367 SEVAQWRTKYETDAIQRTEELEE 1389
Score = 95.5 bits (236), Expect = 2e-19
Identities = 118/495 (23%), Positives = 220/495 (44%), Gaps = 47/495 (9%)
Query: 561 ELGSEVSTS-VMRLKLEVEEKKQAMLL--LQRALAQQRDLTARRVKETEKALSRQLQRQR 617
EL E+ R K E + A L L L + +T+ +++ +K + L+ +R
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 618 EHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQED---QRCTERVAQAQAQHELEI 674
+ EAT+Q H A + L +K VAEL ++ QR +++ + +++ +LEI
Sbjct: 1178 DLEEATLQ-HEAMV-------AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229
Query: 675 KKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKS------ 728
L M + K++ +T + + RG EIQ+ ++ + RL++
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELS 1289
Query: 729 --LHEAELLQSD-ERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQ 785
L E E + S R+ Q +Q EEL+ QLE E +A + A Q R + + LR+Q
Sbjct: 1290 RQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA--KNALAHALQSSRHDCDLLREQ 1347
Query: 786 LEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELE---RQAWEAGRTRKEEAWL 842
EE RA + E + R + E + +++ ELE ++ + + +E+
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407
Query: 843 LNREQELREEIRKGRDKEIELVIHRLEA--DMALAKEESEKAAESRIKRLRDKYEAELSE 900
+N + E+ ++ E+E ++ +E +A A ++ ++ + + + K E +E
Sbjct: 1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE 1467
Query: 901 LEQSER----------KLQERCSELKGQLGEAEGENLRL-QGLVRQKERALEDAQAVNEQ 949
LE S + KL+ E QL + EN L Q + E+ E+ + ++E
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Query: 950 LSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTALARKE 1009
S + Q+ ++ + +LA E E E L R QLEL +V + +A K+
Sbjct: 1528 EKSRK----QIELEKADIQLALEEAEAALEHEEAKIL--RIQLELTQVKSEIDRKIAEKD 1581
Query: 1010 EAVSSLRTQHEAAVK 1024
E + L+ ++ V+
Sbjct: 1582 EEIEQLKRNYQRTVE 1596
Score = 67.8 bits (164), Expect = 5e-11
Identities = 94/427 (22%), Positives = 191/427 (44%), Gaps = 49/427 (11%)
Query: 564 SEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQLQRQREHYEAT 623
+++ ++ + +E ++ +L +Q L Q + R++ E ++ ++++ + +Y+ T
Sbjct: 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE----EIEQLKRNYQRT 1594
Query: 624 IQRHLAFIDQLIEDKKV---LSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKEL 680
++ + +D + + L +K E + E++ + + A+ +LK+
Sbjct: 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 1654
Query: 681 MSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQSDER 740
+ A R + ++ I E L+ E+++L A +Q R + L E ELL S+ER
Sbjct: 1655 QLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ-TERARKLAEQELLDSNER 1713
Query: 741 ASQRCLRQAE--ELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALR 798
+ +++LE + L + + +R + AE E++ A+T A
Sbjct: 1714 VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAE--------EKAKKAITDAAM 1765
Query: 799 AEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRD 858
E +E+ H L +K+ LE +T K+ L+ ++L + K +
Sbjct: 1766 MAEELKKEQDTSAH---LERMKKNLE---------QTVKDLQHRLDEAEQLALKGGKKQI 1813
Query: 859 KEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSEL---EQSERKLQERCSEL 915
+++E I LE ++ + E +K ES +K LR KYE + EL + +RK R +L
Sbjct: 1814 QKLETRIRELEFEL---EGEQKKNTES-VKGLR-KYERRVKELTYQSEEDRKNVLRLQDL 1868
Query: 916 KGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEE 975
+L ++++ RQ E A E A N L+ R AQ +E E+R +E +
Sbjct: 1869 VDKL------QVKVKSYKRQAEEADEQA---NAHLTKFRK--AQHELEEAEERADIAESQ 1917
Query: 976 TRQAKAE 982
+ +A+
Sbjct: 1918 VNKLRAK 1924
Score = 65.9 bits (159), Expect = 2e-10
Identities = 99/398 (24%), Positives = 167/398 (41%), Gaps = 64/398 (16%)
Query: 676 KLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSL-HEAEL 734
K+K L+ + E + + E+ +K K+ E+ K A+ K+ +L +L E
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKD--------ELAKSEAKRKELEEKLVTLVQEKND 887
Query: 735 LQSDERASQRCLRQAEELREQLEREK---EALGQQERERARQRQR--AELEELRQQLEES 789
LQ +A L AEE +QL + K EA ++ ERA + AEL +++LE+
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947
Query: 790 SSALTRALR-AEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQE 848
S L + + E + E+E+ H E EL + +E+ L Q+
Sbjct: 948 CSELKKDIDDLELTLAKVEKEK-HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 849 LREEIRKGRDK---------EIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELS 899
++++ DK ++E + LE+ + E EK ++R + K E +L
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-----EQEKKLRVDLERNKRKLEGDLK 1061
Query: 900 ELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQ 959
++S L+ +L +L + + E +LQ V ED Q + Q + L
Sbjct: 1062 LAQESILDLENDKQQLDERLKKKDFEYCQLQSKV-------EDEQTLGLQFQKKIKELQA 1114
Query: 960 VIRQEFEDRLAASEEETRQAKAELATLQARQQLELEEVHRRVKTA---------LARKEE 1010
I +E E+ + A R +A+ ++ ELEE+ R++ A L +K E
Sbjct: 1115 RI-EELEEEIEAE----RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKRE 1169
Query: 1011 A--------VSSLRTQHEAAV-----KRADHLEELLEQ 1035
A + QHEA V K AD + EL EQ
Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ 1207
Score = 61.6 bits (148), Expect = 4e-09
Identities = 74/316 (23%), Positives = 138/316 (43%), Gaps = 37/316 (11%)
Query: 747 RQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSALTRALRAEFEKGRE 806
++ ++E+ ++ K+ L + E +R ELEE L + + L ++AE E +
Sbjct: 848 KEMATMKEEFQKTKDELAKSEAKR------KELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 807 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 866
+ER Q+ +K + +LE + E ++E + EL + RK D+ EL
Sbjct: 902 AEERCDQL----IKAKFQLEAKIKEVTERAEDEEEI---NAELTAKKRKLEDECSELKKD 954
Query: 867 RLEADMALAKEESEK-AAESRIKRLRDK---YEAELSELEQSERKLQERCSELKGQLGEA 922
+ ++ LAK E EK A E+++K L ++ + +++L + ++ LQE + L
Sbjct: 955 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Query: 923 EGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEE-------- 974
E + L + E+ +ED ++ EQ R +L + R+ D A E
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 975 ---ETRQAKAELATLQARQQLELEEV-----HRRVKTALARKEEAVSSLRTQHEAAVK-- 1024
+ R K + Q + ++E E+ +++K AR EE + + K
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 1025 --RADHLEELLEQHRR 1038
R+D+ EL E R
Sbjct: 1135 KQRSDYARELEELSER 1150
Score = 53.1 bits (126), Expect = 1e-06
Identities = 68/302 (22%), Positives = 128/302 (42%), Gaps = 73/302 (24%)
Query: 779 LEELRQ----QLEESSSALTRA--LRAEFEKGREEQERRHQMELNTLKQQLELERQAW-- 830
LEE+R +L + A+ R +R EF+K + +E ++ N ++ + ++ W
Sbjct: 774 LEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYN-IRSFMNVKHWPWMK 832
Query: 831 ---------EAGRTRKEEAWLLNREQELREEIRKGRDKEIEL---------------VIH 866
++ T KE A + Q+ ++E+ K K EL +
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV 892
Query: 867 RLEADMALAKEE-------SEKAAESRIKRLRDKYEAEL---SELEQSERKLQERCSELK 916
+ E++ L EE ++ E++IK + ++ E E +EL +RKL++ CSELK
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 952
Query: 917 GQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEET 976
+ + E L L + ++K + + E+LS +A++ T
Sbjct: 953 KDIDDLE---LTLAKVEKEKHATENKVKNLTEELSGLDETIAKL---------------T 994
Query: 977 RQAKAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEELLEQH 1036
R+ KA L+E H++ L +E+ V+SL ++ + LE LEQ
Sbjct: 995 REKKA------------LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQE 1042
Query: 1037 RR 1038
++
Sbjct: 1043 KK 1044
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,064,133
Number of Sequences: 37866
Number of extensions: 2253347
Number of successful extensions: 34334
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 534
Number of HSP's successfully gapped in prelim test: 1601
Number of HSP's that attempted gapping in prelim test: 12247
Number of HSP's gapped (non-prelim): 9762
length of query: 1044
length of database: 18,247,518
effective HSP length: 112
effective length of query: 932
effective length of database: 14,006,526
effective search space: 13054082232
effective search space used: 13054082232
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.