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Search of human proteins with 169174934
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
(660 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 1430 0.0
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 1381 0.0
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 1381 0.0
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 236 4e-62
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 225 1e-58
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 196 7e-50
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 176 5e-44
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 172 9e-43
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 170 4e-42
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 154 2e-37
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 150 5e-36
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 146 5e-35
gi|145309328 papilin [Homo sapiens] 144 2e-34
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 140 4e-33
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 140 5e-33
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 138 2e-32
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 137 3e-32
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 124 2e-28
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 124 2e-28
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 124 3e-28
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 120 3e-27
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 119 9e-27
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 115 2e-25
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 108 1e-23
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 108 1e-23
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 105 2e-22
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ... 102 1e-21
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ... 100 4e-21
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 89 1e-17
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 83 7e-16
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 1430 bits (3702), Expect = 0.0
Identities = 660/660 (100%), Positives = 660/660 (100%)
Query: 1 MQRRGPTWACLEDCDALLPVPRVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAE 60
MQRRGPTWACLEDCDALLPVPRVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAE
Sbjct: 1 MQRRGPTWACLEDCDALLPVPRVWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAE 60
Query: 61 SQGLDGAGLMGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAG 120
SQGLDGAGLMGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAG
Sbjct: 61 SQGLDGAGLMGFIPHNGSLYGQASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAG 120
Query: 121 GGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKD 180
GGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKD
Sbjct: 121 GGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKD 180
Query: 181 FTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPF 240
FTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPF
Sbjct: 181 FTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPF 240
Query: 241 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMC 300
PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMC
Sbjct: 241 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMC 300
Query: 301 VRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWK 360
VRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWK
Sbjct: 301 VRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWK 360
Query: 361 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDI 420
MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDI
Sbjct: 361 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDI 420
Query: 421 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 480
RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV
Sbjct: 421 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 480
Query: 481 VPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT 540
VPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT
Sbjct: 481 VPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT 540
Query: 541 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 600
RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD
Sbjct: 541 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 600
Query: 601 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 660
PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 601 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 660
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 1381 bits (3574), Expect = 0.0
Identities = 637/638 (99%), Positives = 638/638 (100%)
Query: 23 VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQ 82
VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGF+PHNGSLYGQ
Sbjct: 314 VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQ 373
Query: 83 ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 142
ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP
Sbjct: 374 ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 433
Query: 143 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 202
LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE
Sbjct: 434 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 493
Query: 203 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 262
SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP
Sbjct: 494 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 553
Query: 263 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 322
KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV
Sbjct: 554 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 613
Query: 323 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 382
HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR
Sbjct: 614 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
Query: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 442
PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT
Sbjct: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 733
Query: 443 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 502
GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN
Sbjct: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 793
Query: 503 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 562
CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP
Sbjct: 794 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 853
Query: 563 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622
CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD
Sbjct: 854 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
Query: 623 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 660
DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 914 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 1381 bits (3574), Expect = 0.0
Identities = 637/638 (99%), Positives = 638/638 (100%)
Query: 23 VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFIPHNGSLYGQ 82
VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGF+PHNGSLYGQ
Sbjct: 314 VWNQNGKSPSITFEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQ 373
Query: 83 ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 142
ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP
Sbjct: 374 ASSERLGLDNRLFGHPGLDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTP 433
Query: 143 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 202
LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE
Sbjct: 434 LTGDKDDEEVDTHFASQEFFSANAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAE 493
Query: 203 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 262
SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP
Sbjct: 494 SFFVDYEENEGAGPYLLNGSYLELSSDRVANSSSEAPFPNVSTSLLTSAGNRTHKARTRP 553
Query: 263 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 322
KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV
Sbjct: 554 KARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPV 613
Query: 323 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 382
HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR
Sbjct: 614 HEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 673
Query: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 442
PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT
Sbjct: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 733
Query: 443 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 502
GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN
Sbjct: 734 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN 793
Query: 503 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 562
CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP
Sbjct: 794 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 853
Query: 563 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622
CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD
Sbjct: 854 CFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
Query: 623 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 660
DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS
Sbjct: 914 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS 951
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 236 bits (603), Expect = 4e-62
Identities = 139/435 (31%), Positives = 205/435 (47%), Gaps = 28/435 (6%)
Query: 241 PNVSTSLLTSAGNRTHKARTRPKARKQGVSPADM-------YRWKLSSHEPCSATCTTGV 293
P + TS H R P V PA + WK CS TC G
Sbjct: 578 PEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGS 637
Query: 294 MSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQ 352
CV R E +SYCD+ +P P E C C W+ WSECS+TCG G Q
Sbjct: 638 QYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQ 697
Query: 353 FRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM-SEWSECTAKCG 411
R V C + + +V C+ E +PE TC+ C +W++ ++W+ C+ CG
Sbjct: 698 HRQVLC-RQVYANRSLTVQPYRCQHLE--KPETTSTCQLKICS-EWQIRTDWTSCSVPCG 753
Query: 412 ERSVVTRDIRCSE------DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP-CSGSCGQ 464
TRD++C D++ C+ RP +NC PC + W +++W CS CG
Sbjct: 754 V-GQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGA 812
Query: 465 GRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNC--PAHWLAQDWERCNTTCGRG 522
G R V C T+ +P C +P PC + C W A W +C+ CG G
Sbjct: 813 GVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSG 871
Query: 523 VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVG 581
++R V+C+ + EC +KPP + +C +PC KW+++ WS C+K+C G
Sbjct: 872 TQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGG 931
Query: 582 VRMRDVKCYQGTDIVRG-CDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVN 640
R+R+V+C + CDP +KP R++C+ Q C E D++C+D+ NC + ++
Sbjct: 932 FRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE-VDENCKDK-YYNCNVVVQAR 989
Query: 641 LCGHWYYSKACCRSC 655
LC + YY ACC SC
Sbjct: 990 LCVYNYYKTACCASC 1004
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 225 bits (573), Expect = 1e-58
Identities = 130/403 (32%), Positives = 190/403 (47%), Gaps = 32/403 (7%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 335
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 336 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 395
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
Query: 396 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 446
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
Query: 447 DRQWTVSDW-GPCSGSCGQGRTIRHVYCKTSDGRVVP---------ESQCQMETKPLAIH 496
W SDW CS CG G R V C S + P C ++P +
Sbjct: 842 TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMR 901
Query: 497 PCGDKNCPA--HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPE 554
C C W W C++ CG G ++R ++C+ + S C +PP
Sbjct: 902 ACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPA 961
Query: 555 ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQ-GTDIVRGCDPLVKPVGRQACD 612
C + C +W+++PWS C+++C G + R+V+C + C P ++P ++ C+
Sbjct: 962 LQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCN 1021
Query: 613 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 655
QPC ++ PDD C+D +C L ++ LC + YY+ CCRSC
Sbjct: 1022 SQPC-SQRPDDQCKDS-SPHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 66.2 bits (160), Expect = 9e-11
Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 13/137 (9%)
Query: 262 PKARKQGVSPADM-YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALT 317
P R + P + +RW CS+ C +G +CV G E S C L
Sbjct: 898 PDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLP 957
Query: 318 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
RP P + C G+ CQ RW ++ WS CSR+C G Q R V+C + S C
Sbjct: 958 RP-PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLS------TNQTLSTRC-- 1008
Query: 378 AEAVRPEERKTCRNPAC 394
+RP ++ C + C
Sbjct: 1009 PPQLRPSRKRPCNSQPC 1025
Score = 65.1 bits (157), Expect = 2e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 483 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 541
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
Query: 542 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 600
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
Query: 601 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 645
+ + P + C P N + ++ LCGHW
Sbjct: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 196 bits (497), Expect = 7e-50
Identities = 110/352 (31%), Positives = 160/352 (45%), Gaps = 25/352 (7%)
Query: 276 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC--QP 333
+W + C+ C G+ + +C R +G D C+ L +P P E C C
Sbjct: 1385 QWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP-PDREQCNTHACPHDA 1443
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
W T WS CS +CG G++ R V C M G S + SD C+ +P + CR
Sbjct: 1444 AWSTGPWSSCSVSCGRGHKQRNVYC--MAKDG--SHLESDYCK--HLAKPHGHRKCRGGR 1497
Query: 394 CGPQWEMSEWSECTAKCGERSVVTRDIRCS------EDEKLCDPNTRPVGEKNCTGPPCD 447
C P+W+ WS+C+ CG R V R + C E C+P TRP E++C GP C
Sbjct: 1498 C-PKWKAGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Query: 448 RQ-WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 506
W +W C+ +CG+G R V C + V ++C + +P+ C + C
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
Query: 507 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKKPPEESTCFERPC 563
W+ +W C+ TCG+G K+RLV C E+ GK + + +PP C+ R C
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675
Query: 564 ---FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQAC 611
W W C+ +CGVGV R V+C D C +KP R+ C
Sbjct: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
Score = 193 bits (491), Expect = 4e-49
Identities = 129/403 (32%), Positives = 170/403 (42%), Gaps = 64/403 (15%)
Query: 261 RPKARKQ-GVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 319
RP A+++ V+P +WK CS TC G + MCV Y +D S CD P
Sbjct: 1227 RPVAKEECSVTPCG--QWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
Query: 320 EPVHEFCAGRECQPR---------------------------------WETSSWSECSRT 346
E + C+ C R W T W CS T
Sbjct: 1285 ETDQD-CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSST 1343
Query: 347 CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 406
C G Q RVV C D + Y+ + E ++P+E++ C + C PQW W EC
Sbjct: 1344 CAGGSQRRVVVCQ-------DENGYT-ANDCVERIKPDEQRACESGPC-PQWAYGNWGEC 1394
Query: 407 TAKCGERSVVTRDIRC--SEDEKL----CDPNTRPVGEKNCTGPPC--DRQWTVSDWGPC 458
T CG + TR + C S E+ C+ +P + C C D W+ W C
Sbjct: 1395 TKLCGG-GIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSC 1453
Query: 459 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT 518
S SCG+G R+VYC DG + C+ KP C CP W A W +C+ +
Sbjct: 1454 SVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVS 1512
Query: 519 CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPWSECTK 576
CGRGV++R V C G + EC +P E C C + W W ECTK
Sbjct: 1513 CGRGVQQRHVGCQI---GTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTK 1569
Query: 577 TCGVGVRMRDVKCYQGT-DIVRG--CDPLVKPVGRQACDLQPC 616
TCG G R R V C + V G CD +PV R++C LQPC
Sbjct: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 190 bits (482), Expect = 4e-48
Identities = 128/440 (29%), Positives = 180/440 (40%), Gaps = 79/440 (17%)
Query: 257 KARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDAL 316
K + K Q S +WK C TC G C ++ ++D CD
Sbjct: 1036 KCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLNDRMCDPE 1094
Query: 317 TRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCE 376
T+P + + C EC W+ W +CS TCG+GYQ R V+C + + S V + C
Sbjct: 1095 TKPTSM-QTCQQPECAS-WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCN 1149
Query: 377 AAEAVRPEERKTCRNPACGP-----------------QWEMSEWSECTAKCGE----RSV 415
AA RP + + C P+C P QW W+ C+A CG+ R V
Sbjct: 1150 AA--TRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYV 1207
Query: 416 VTRDIRCS-EDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCK 474
RD S DE C RPV ++ C+ PC QW DW CS +CGQGR R V C
Sbjct: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCV 1266
Query: 475 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH---------------------------- 506
V+ S+C + P C CP
Sbjct: 1267 NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHV 1326
Query: 507 -----WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFER 561
W W C++TC G ++R+V+C + NG + +C KP E+ C
Sbjct: 1327 LGGNQWRTGPWGACSSTCAGGSQRRVVVCQD-ENGY----TANDCVERIKPDEQRACESG 1381
Query: 562 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGT-----DIVRGCDPLVKPVGRQACDLQPC 616
PC +W W ECTK CG G+R R V C + D+ C+ L KP R+ C+ C
Sbjct: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDL--SCEILDKPPDREQCNTHAC 1439
Query: 617 PTEPPDDSCQDQPGTNCALA 636
P D + P ++C+++
Sbjct: 1440 ---PHDAAWSTGPWSSCSVS 1456
Score = 188 bits (477), Expect = 2e-47
Identities = 121/388 (31%), Positives = 162/388 (41%), Gaps = 45/388 (11%)
Query: 276 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-----VDDSYCDALTRPEPVHEFCAGRE 330
RW ++S CSA C G + C +Y ++ VDD +C + +P E C+G
Sbjct: 938 RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN-REKCSGEC 996
Query: 331 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 390
W S+W+ECS++C G Q R C + D S C E V + C
Sbjct: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDS----KCTHQEKVTIQR---CS 1049
Query: 391 NPACGPQWEMSEWSECTAKCGERSVVTRDIRC--SED---EKLCDPNTRPVGEKNCTGPP 445
C PQW+ +WSEC CG + R + C ED +++CDP T+P + C P
Sbjct: 1050 EFPC-PQWKSGDWSECLVTCG-KGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPE 1107
Query: 446 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAIHPCGDKNC- 503
C W WG CS +CGQG +R V C VV ++ C T+P C +C
Sbjct: 1108 C-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCH 1166
Query: 504 --PA--------------HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 547
PA W W C+ TCG+G + R V C + NG S C
Sbjct: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRD-ENGSVADESA--CA 1223
Query: 548 LAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---RGCDPLVK 604
+P + C PC +W WS C+ TCG G R V C +D V CD
Sbjct: 1224 TLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYI 1283
Query: 605 PVGRQACDLQPCPTEPPDDSCQDQPGTN 632
P Q C + PCP PD P N
Sbjct: 1284 PETDQDCSMSPCPQRTPDSGLAQHPFQN 1311
Score = 177 bits (450), Expect = 2e-44
Identities = 115/415 (27%), Positives = 174/415 (41%), Gaps = 73/415 (17%)
Query: 261 RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPE 320
+P R++ + W+ S+ CS +C G A+CV +DDS C T E
Sbjct: 985 KPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKC---THQE 1041
Query: 321 PVH-EFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAA 378
V + C+ C P+W++ WSEC TCG+G++ R V C F +D +C+
Sbjct: 1042 KVTIQRCSEFPC-PQWKSGDWSECLVTCGKGHKHRQVWCQ------FGEDRLNDRMCDPE 1094
Query: 379 EAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCS-------EDEKLCDP 431
+P +TC+ P C W+ W +C+ CG+ R ++C D+ C+
Sbjct: 1095 --TKPTSMQTCQQPECA-SWQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNA 1150
Query: 432 NTRPVGEKNCTGPPCD-----------------RQWTVSDWGPCSGSCGQGRTIRHVYCK 474
TRP ++C P C QW W PCS +CG+G +R+V C+
Sbjct: 1151 ATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210
Query: 475 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 534
+G V ES C +P+A C C W A DW C+ TCG+G R V+C+ +
Sbjct: 1211 DENGSVADESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYS 1269
Query: 535 NG---------------------KPQTRSGPECGLAKKPPEESTCFERPCF--------- 564
+ P + P+ GLA+ P + R
Sbjct: 1270 DHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
Query: 565 -KWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 617
+W T PW C+ TC G + R V C + C +KP ++AC+ PCP
Sbjct: 1330 NQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
Score = 134 bits (337), Expect = 3e-31
Identities = 98/356 (27%), Positives = 147/356 (41%), Gaps = 35/356 (9%)
Query: 316 LTRPEPVHEFCAGRECQPR---WETSS-WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
L P+ + F E +P+ W + W CS+ C +G + R + C + +V
Sbjct: 859 LYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPC-QGERKRKLVCTRESD---QLTVS 914
Query: 372 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE------- 424
C+ +P C +W ++ SEC+A+CG T DI C++
Sbjct: 915 DQRCDRLP--QPGHITEPCGTDCDLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGK 971
Query: 425 ----DEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 480
D+ C + +P + C+G W S W CS SC G R C + V
Sbjct: 972 TEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV 1031
Query: 481 VPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT 540
+ +S+C + K + I C + CP W + DW C TCG+G K R V C + +
Sbjct: 1032 LDDSKCTHQEK-VTIQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLND 1088
Query: 541 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---- 596
R C KP TC + C W PW +C+ TCG G ++R VKC GT +
Sbjct: 1089 RM---CDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDD 1145
Query: 597 RGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACC 652
C+ +P Q C+L C PP + + + T A + G W A C
Sbjct: 1146 NDCNAATRPTDTQDCELPSC--HPPPAAPETRRSTYSAPRTQWRF-GSWTPCSATC 1198
Score = 90.9 bits (224), Expect = 3e-18
Identities = 56/190 (29%), Positives = 87/190 (45%), Gaps = 11/190 (5%)
Query: 260 TRPKARKQGVSP-ADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTR 318
TRP++ + P +Y W+ + C+ TC G +CV + EV + CD R
Sbjct: 1541 TRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKR 1600
Query: 319 PEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYS-DLCEA 377
P E C+ + C+ W T WSECS TCG+GY+ R+V C ++ + G ++ YS
Sbjct: 1601 PVD-RESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYT-GKENYEYSYQTTIN 1658
Query: 378 AEAVRPEERKTC--RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDE----KLCDP 431
+P C R+ W + W C+ CG V+ R ++C +E LC
Sbjct: 1659 CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGV-GVMQRSVQCLTNEDQPSHLCHT 1717
Query: 432 NTRPVGEKNC 441
+ +P K C
Sbjct: 1718 DLKPEERKTC 1727
Score = 58.5 bits (140), Expect = 2e-08
Identities = 49/151 (32%), Positives = 60/151 (39%), Gaps = 21/151 (13%)
Query: 253 NRTHKART----RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVR-YDGVE 307
N H AR RP R+ Y W CS TC G C Y G E
Sbjct: 1588 NEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKE 1647
Query: 308 -VDDSYCDAL----TRPEPVHEFCAGREC--QPRWETSSWSECSRTCGEGYQFRVVRCWK 360
+ SY + T+P VH C R+C W +W CS +CG G R V+C
Sbjct: 1648 NYEYSYQTTINCPGTQPPSVHP-CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLT 1706
Query: 361 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 391
+ S LC ++PEERKTCRN
Sbjct: 1707 ------NEDQPSHLCHTD--LKPEERKTCRN 1729
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 176 bits (447), Expect = 5e-44
Identities = 110/393 (27%), Positives = 160/393 (40%), Gaps = 65/393 (16%)
Query: 274 MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 333
M +W+ S PCS +C G + Y C D+SYC L RP + + C
Sbjct: 1153 MAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFT--PCG- 1209
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
W+ WS CS +CG G R V C P + + C+ VRP + C A
Sbjct: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQP-----IDENYCDPE--VRPLMEQECSLAA 1262
Query: 394 CGP-----------------------------------------QWEMSEWSECTAKCG- 411
C P QW W C++ C
Sbjct: 1263 CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG 1322
Query: 412 ---ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTI 468
R+VV +D + CD ++P + C PC QW +WG CS +CG G
Sbjct: 1323 GLQHRAVVCQDEN-GQSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGIKS 1380
Query: 469 RHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA--HWLAQDWERCNTTCGRGVKKR 526
R V C+ +G+++ + C++ KP ++ C CPA W + W C+ +CG+G K R
Sbjct: 1381 RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYR 1440
Query: 527 LVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRD 586
V C++ K + + C +KPP C C W + W+EC+ TCG GV+ RD
Sbjct: 1441 EVFCIDQFQRKLEDTN---CSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRD 1497
Query: 587 VKCY---QGTDIVRGCDPLVKPVGRQACDLQPC 616
V C G + CD +P ++ C Q C
Sbjct: 1498 VYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Score = 175 bits (443), Expect = 1e-43
Identities = 111/373 (29%), Positives = 154/373 (41%), Gaps = 46/373 (12%)
Query: 276 RWKLSSHEPCSATCTTGVMSAYAMCVRYD-----GVEVDDSYCDALTRPEPVHEFCAGRE 330
RW + CS+ C G + C++Y V+VDD YC +P P E C G
Sbjct: 907 RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKP-PTQELCHGNC 965
Query: 331 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 390
RW S WS+CSR+CG G + R C F + + C+ V R+ C
Sbjct: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCMN----NFGHRLADNECQELSRV---TRENCN 1018
Query: 391 NPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-----EKLCDPNTRPVGEKNCTGPP 445
+C P W SEWSEC CG + R + C + + C+ +T+P C
Sbjct: 1019 EFSC-PSWAASEWSECLVTCG-KGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHT 1076
Query: 446 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIHPCGDKNCP 504
C W V WGPC+ +CG G +R V C V+ +++C ++P C C
Sbjct: 1077 C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135
Query: 505 ------------------AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPEC 546
A W W C+ +CGRG + R V C + + + C
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD---RIADESYC 1192
Query: 547 GLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRGCDPLVK 604
+P E CF PC +W WS C+ +CG G R V C Y CDP V+
Sbjct: 1193 AHLPRPAEIWDCF-TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
Query: 605 PVGRQACDLQPCP 617
P+ Q C L CP
Sbjct: 1252 PLMEQECSLAACP 1264
Score = 162 bits (410), Expect = 9e-40
Identities = 118/413 (28%), Positives = 154/413 (37%), Gaps = 92/413 (22%)
Query: 276 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 335
RW S CS +C G S + C+ G + D+ C L+R E C C P W
Sbjct: 969 RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRV--TRENCNEFSC-PSW 1025
Query: 336 ETSSWSECSRTCGEGYQFRVVRCW---KMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNP 392
S WSEC TCG+G + R V C LS GF +S + +PE C
Sbjct: 1026 AASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNS----------STKPESLSPCELH 1075
Query: 393 ACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGPP 445
C W++ W CT CG RD++C + + C +RP ++C P
Sbjct: 1076 TCA-SWQVGPWGPCTTTCGH-GYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTP 1133
Query: 446 CD------------------RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQ 487
C QW W PCS SCG+G R+V C+ + R+ ES C
Sbjct: 1134 CSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCA 1193
Query: 488 METKPLAI----HPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 543
+P I PCG+ W A DW C+ +CG G R VLCM +
Sbjct: 1194 HLPRPAEIWDCFTPCGE------WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCD 1247
Query: 544 P--------ECGLAKKPPEESTCFERPC------------------------------FK 565
P EC LA PP S P +
Sbjct: 1248 PEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQ 1307
Query: 566 WYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 617
W T PW C+ +C G++ R V C + CD KP Q C PCP
Sbjct: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCP 1360
Score = 149 bits (376), Expect = 8e-36
Identities = 109/378 (28%), Positives = 158/378 (41%), Gaps = 47/378 (12%)
Query: 272 ADMYRWK-LSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGR 329
+DM+ W E C+ C G+ C+ + D V D CD L P V + C
Sbjct: 845 SDMFTWDPYGPWEGCTKMCQ-GLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSC-NT 902
Query: 330 ECQPRWETSSWSECSRTCGEGYQFRVVRCWK-MLSPGFDSSVYSDLCEAAEAVRPEERKT 388
+C+ RW SECS CG+GY+ + C K + G V C + ++P ++
Sbjct: 903 DCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYC--GDQLKPPTQEL 960
Query: 389 CRNPACGPQWEMSEWSECTAKC--GERSVVTRDIRCSED--EKLCDPNTRP---VGEKNC 441
C +W SEWS+C+ C GERS R+ C + +L D + V +NC
Sbjct: 961 CHGNCVFTRWHYSEWSQCSRSCGGGERS---RESYCMNNFGHRLADNECQELSRVTRENC 1017
Query: 442 TGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 501
C W S+W C +CG+G R V+C+ + + + C TKP ++ PC
Sbjct: 1018 NEFSCP-SWAASEWSECLVTCGKGTKQRQVWCQLNVDH-LSDGFCNSSTKPESLSPCELH 1075
Query: 502 NCPAHWLAQDWERCNTTCGRGVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCFE 560
C A W W C TTCG G + R V C+ ELA+ EC A +P + +C
Sbjct: 1076 TC-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSCVL 1131
Query: 561 RPC-------------------FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--- 598
PC +W W+ C+ +CG G + R V C D +
Sbjct: 1132 TPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY 1191
Query: 599 CDPLVKPVGRQACDLQPC 616
C L +P C PC
Sbjct: 1192 CAHLPRPAEIWDC-FTPC 1208
Score = 135 bits (340), Expect = 1e-31
Identities = 94/369 (25%), Positives = 151/369 (40%), Gaps = 30/369 (8%)
Query: 267 QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 326
Q P +W + CS TC G+ S +C +G ++D C+ + +P V + C
Sbjct: 1352 QQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ-C 1410
Query: 327 AGRECQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE 384
C W W+ CS +CG+G ++R V C + + ++ +P
Sbjct: 1411 HMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT------NCSQVQKPP 1464
Query: 385 ERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED------EKLCDPNTRPVGE 438
K CR+ C P W+ + W+EC+ CG V RD+ C E++CD +TRP +
Sbjct: 1465 THKACRSVRC-PSWKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQ 1522
Query: 439 KNCTGPPCDRQWTVSDWG-PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP 497
+ C C + + CS SC + + + + C + R V E T L
Sbjct: 1523 RRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKN 1582
Query: 498 CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQT--RSGP----ECGLAKK 551
C + C + D +C CG ++R+ C E+ + K R P EC +
Sbjct: 1583 CRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVV-- 1640
Query: 552 PPEESTCFERPCFK---WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVG 607
P + C W WS+C+ TCG+G+ R VKC + C +KP
Sbjct: 1641 PSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGA 1700
Query: 608 RQACDLQPC 616
++ C C
Sbjct: 1701 QKKCYANDC 1709
Score = 123 bits (309), Expect = 5e-28
Identities = 92/353 (26%), Positives = 144/353 (40%), Gaps = 31/353 (8%)
Query: 276 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 335
+W+ CS++C+ G+ +C +G SYCDA ++P + + C C P+W
Sbjct: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA--SYCDAASKPPELQQ-CGPGPC-PQW 1362
Query: 336 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDL-CEAAEAVRPEERKTCRNPAC 394
+W ECS+TCG G + R+V C + + D CE +P C AC
Sbjct: 1363 NYGNWGECSQTCGGGIKSRLVICQFP-----NGQILEDHNCEIVN--KPPSVIQCHMHAC 1415
Query: 395 GPQ--WEMSEWSECTAKCGERSVVTRDIRCSED--EKLCDPNT----RPVGEKNCTGPPC 446
W W+ C+A CG+ R++ C + KL D N +P K C C
Sbjct: 1416 PADVSWHQEPWTSCSASCGKGRKY-REVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
Query: 447 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 506
W + W CS +CG G R VYC+ V E C T+P + C ++C H
Sbjct: 1475 P-SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQH 1533
Query: 507 -WLAQDWERCNTTCGRGVKKRLVLCM--ELANGKPQTRSGPECGLAKKPPEESTCFERPC 563
+ + C+T+C R + + C ++ + L K C PC
Sbjct: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSK-----NCRNPPC 1588
Query: 564 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQP 615
+ T+ S+C CG R R C + + ++P+ Q C + P
Sbjct: 1589 NYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVP 1641
Score = 31.6 bits (70), Expect = 2.4
Identities = 15/42 (35%), Positives = 18/42 (42%), Gaps = 6/42 (14%)
Query: 323 HEFCAGRECQPRWETSSW------SECSRTCGEGYQFRVVRC 358
H C +E + R W S CSRTCG G + RC
Sbjct: 542 HGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRC 583
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 172 bits (436), Expect = 9e-43
Identities = 116/345 (33%), Positives = 153/345 (44%), Gaps = 40/345 (11%)
Query: 341 SECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEM 400
SECS +CG GY C + ++ V S C +A+ E K C +C W
Sbjct: 883 SECSVSCGGGYINVKAICLR----DQNTQVNSSFC-SAKTKPVTEPKICNAFSCPAYWMP 937
Query: 401 SEWSECTAKC--GERSVVTRDIRCSEDE----------KLCDPNTRPVGEKNCTGPPCDR 448
EWS C+ C G++S R I+C + + LC P + P + C C
Sbjct: 938 GEWSTCSKACAGGQQS---RKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNSHACPP 993
Query: 449 QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH-- 506
QW++ W CS +CG+G R + CK S +PESQC +P C CP +
Sbjct: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSR 1053
Query: 507 --WLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQTRSGPECGLAKKP--PEESTCFER 561
W+A W C+ TCG GV+KR + C E GK T C KKP E TC R
Sbjct: 1054 LQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRR 1113
Query: 562 PC---------FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACD 612
C WY+ PW +CT TCG GV+ R V C Q C KP +AC+
Sbjct: 1114 ACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACN 1173
Query: 613 LQ--PCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 655
P P + D SC D C L + +C H +Y K CC+SC
Sbjct: 1174 TNFCPAPEKREDPSCVDFFNW-CHLVPQHGVCNHKFYGKQCCKSC 1217
Score = 35.4 bits (80), Expect = 0.17
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 10/41 (24%)
Query: 319 PEPVHEFCAGRECQPRWET-SSWSECSRTCGEGYQFRVVRC 358
P P+H +W S WSECSRTCG G +F+ C
Sbjct: 585 PRPIHG---------QWSAWSKWSECSRTCGGGVKFQERHC 616
Score = 33.5 bits (75), Expect = 0.64
Identities = 16/48 (33%), Positives = 23/48 (47%)
Query: 569 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 616
S WSEC++TCG GV+ ++ C G Q C++ PC
Sbjct: 596 SKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 170 bits (430), Expect = 4e-42
Identities = 110/367 (29%), Positives = 159/367 (43%), Gaps = 47/367 (12%)
Query: 328 GRECQPRWETS-SW----SECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 382
G E QP + S +W SECS +CG G C++ L + S + +
Sbjct: 861 GTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLV 920
Query: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE---------DEKLCDPNT 433
P C+ AC P W + WS C+ CG +R ++C+ LC P
Sbjct: 921 P-----CKVSACPPSWSVGNWSACSRTCGG-GAQSRPVQCTRRVHYDSEPVPASLC-PQP 973
Query: 434 RPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD----GRVVPESQCQME 489
P + C C W+ W CS +CG+G R V CK+++ +++P++ C E
Sbjct: 974 APSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSE 1033
Query: 490 TKPLAIHPCGDKNC----PAHWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGP 544
KP C + C WL W +C+ TC RG +KR + C E +GK + +
Sbjct: 1034 PKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASK 1093
Query: 545 ECGLAKKPPEE--STCFERPCFK-------------WYTSPWSECTKTCGVGVRMRDVKC 589
+C KP E C PC + W+ SPWS+CT +CG GV+ R V+C
Sbjct: 1094 KCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
Query: 590 YQGTDIVRGCDPLVKPVGRQACDLQPCP-TEPPDDSCQDQPGTNCALAIKVNLCGHWYYS 648
G GC KP AC+ CP E D C+D C L + +C H +Y
Sbjct: 1154 LAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHW-CYLVPQHGMCSHKFYG 1212
Query: 649 KACCRSC 655
K CC++C
Sbjct: 1213 KQCCKTC 1219
Score = 34.7 bits (78), Expect = 0.29
Identities = 48/212 (22%), Positives = 72/212 (33%), Gaps = 46/212 (21%)
Query: 438 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP 497
E N P + V W PCS R H + T+ + + + KP+ +
Sbjct: 454 EGNIMSPTLAGRNGVFSWSPCS------RQYLHKFLSTAQAICLAD-----QPKPVKEYK 502
Query: 498 CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCM-----ELANGKPQTRSGPECGLAKKP 552
+K L + NT C ++ LCM ++ R G +C P
Sbjct: 503 YPEK------LPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMP 556
Query: 553 PEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMRDVKCYQG 592
E T C C K+ S WS C++TCG GV R C
Sbjct: 557 AAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNP 616
Query: 593 TDIVRG--CDPLVKPVGRQACDLQPCPTEPPD 622
G C+ + + + C+ Q CP + D
Sbjct: 617 KPSHGGKFCEGSTRTL--KLCNSQKCPRDSVD 646
Score = 31.2 bits (69), Expect = 3.2
Identities = 13/21 (61%), Positives = 13/21 (61%)
Query: 338 SSWSECSRTCGEGYQFRVVRC 358
SSWS CSRTCG G R C
Sbjct: 593 SSWSPCSRTCGGGVSHRSRLC 613
Score = 30.4 bits (67), Expect = 5.4
Identities = 19/61 (31%), Positives = 27/61 (44%), Gaps = 6/61 (9%)
Query: 392 PACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCD 447
P G + S WS C+ CG RS + + + S K C+ +TR + K C C
Sbjct: 584 PTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL--KLCNSQKCP 641
Query: 448 R 448
R
Sbjct: 642 R 642
Score = 29.6 bits (65), Expect = 9.3
Identities = 22/92 (23%), Positives = 31/92 (33%), Gaps = 19/92 (20%)
Query: 267 QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 326
+G P + SS PCS TC GV +C T P+P H
Sbjct: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLC----------------TNPKPSH--- 620
Query: 327 AGRECQPRWETSSWSECSRTCGEGYQFRVVRC 358
G+ C+ T + + FR +C
Sbjct: 621 GGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQC 652
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 154 bits (389), Expect = 2e-37
Identities = 102/386 (26%), Positives = 158/386 (40%), Gaps = 75/386 (19%)
Query: 273 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 331
D +W PC+ TC G+ +C+ + G+ C T+P E C
Sbjct: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG--CSPKTKPHIKEECIVPTPCY 493
Query: 332 -----------------------------QPRWETSSWSECSRTCGEGYQFRVVRCWKML 362
+P + +WS C+ TCG G Q R+VRC +L
Sbjct: 494 KPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLL 553
Query: 363 SPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ------------------------W 398
S F SV + E +P ++ C C + W
Sbjct: 554 S--FSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDW 611
Query: 399 EMSEWSECTAKCG---ERSVVT---RDIRCSEDEKLCDPNTRPVGE-KNCTGPPCDRQWT 451
E +++C+ CG + +VV+ + R +E LC + RP K+C PC +W
Sbjct: 612 EYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWE 671
Query: 452 VSDWGPCSGSCGQGRTIRHVYC------KTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 505
+ W PCS +CG G R V+C + ++ ++ + C+ + KP + C NCP
Sbjct: 672 IGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACNRFNCPP 730
Query: 506 HWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC- 563
W W+ C+ TCG GV+KR VLC + +A+G C A KP + C + C
Sbjct: 731 AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDCP 789
Query: 564 FKWYTSPWSECTKTCGVGVRMRDVKC 589
+W S W+EC+ +CG G + R C
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 128 bits (321), Expect = 2e-29
Identities = 83/278 (29%), Positives = 119/278 (42%), Gaps = 36/278 (12%)
Query: 275 YRWKLSSHEPCSATC-TTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 333
Y W + CSA+C GV C+ + EV+ ++C RP C R+C
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCL-LNSTEVNPAHCAGKVRPAVQPIACNRRDCPS 1547
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
RW +SWS C+R+CG G Q R V C K+ + G + V +D+C A RP + + C
Sbjct: 1548 RWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQV-AKRPVDTQACNQQL 1606
Query: 394 CGPQWEMSEWSECTAKC--GERSVVTRDIRCSEDEKL------CDPNTRPVGEKNCTGPP 445
C +W S W +C C +V R + C + + C RPV +NC
Sbjct: 1607 C-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
Query: 446 CDRQWTVSDWGPCSGSCG----QGRTIRHVYCKTSDGRVVPESQCQMETKP-----LAIH 496
C W VS W C+ +CG Q R + V+ +T+ + VPE C +P I
Sbjct: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTN--KAVPEHLCSWGPRPANWQRCNIT 1723
Query: 497 PCGDKNC-------------PAHWLAQDWERCNTTCGR 521
PC + C L+Q RC TCG+
Sbjct: 1724 PCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
Score = 126 bits (316), Expect = 7e-29
Identities = 108/427 (25%), Positives = 159/427 (37%), Gaps = 79/427 (18%)
Query: 269 VSPADMY----RWKLSSHEPCSATCTTGVMSAYAMCVRYD----GVEVDDSYCDALTRPE 320
+ P D+Y RW+ + CS++C G+ S CV D V++ C T
Sbjct: 368 IMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC-MYTPKM 426
Query: 321 PVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSD 373
P+ + C +C P+W WS C+ TCG+G ++RVV C SP + +
Sbjct: 427 PIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEE 485
Query: 374 LCEAAEAVRPEER----------KTCRNPACG------PQWEMSEWSECTAKCGERSVVT 417
+P+E+ K + G P + WS CT CG + V
Sbjct: 486 CIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQV- 544
Query: 418 RDIRC----SEDEKLCD------PNTRPVGEKNCTGPPCDRQ------------------ 449
R +RC S + + D +P ++ C PC +
Sbjct: 545 RIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQD 604
Query: 450 ------WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETK--PLAIHPCGDK 501
W + CS SCG G V C R E + ++ P + C
Sbjct: 605 FDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLD 664
Query: 502 NCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRS--GPECGLAKKPPEESTCF 559
CPA W W C+ TCG G++ R V C L + + E KP C
Sbjct: 665 PCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACN 724
Query: 560 ERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQG------TDIVRGCDPLVKPVGRQACD 612
C WY + W C++TCG GV+ R+V C Q ++ KP +QAC
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACK 784
Query: 613 LQPCPTE 619
CP+E
Sbjct: 785 KDDCPSE 791
Score = 122 bits (306), Expect = 1e-27
Identities = 115/440 (26%), Positives = 174/440 (39%), Gaps = 104/440 (23%)
Query: 274 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 328
++RW+ + PCSATC G A C +R + V V D YC +P+P + C
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356
Query: 329 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
C PRWE + W+ CS +CG G Q R V C + G +SV
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 372 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 428
C + + C C P+W EWS CT CG+ + R + C + +
Sbjct: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472
Query: 429 -CDPNTRPVGEKNCTGP-PCDR-----------QW-----------TVSD--------WG 456
C P T+P ++ C P PC + W VS+ W
Sbjct: 473 GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWS 532
Query: 457 PCSGSCGQGRTIRHVYCK-----TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH----- 506
C+ +CG G +R V C+ + +P +C+ KP + C C
Sbjct: 533 ACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFN 591
Query: 507 -------------------WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 547
W + + +C+ +CG GV++ +V C+ +P + C
Sbjct: 592 PDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN--LCV 649
Query: 548 LAKKPPE-ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC-----YQGTDIVRGCD 600
+++PP+ +C PC +W WS C+ TCGVG++ RDV C + + V D
Sbjct: 650 TSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILAD 709
Query: 601 PLV---KPVGRQACDLQPCP 617
L KP QAC+ CP
Sbjct: 710 ELCRQPKPSTVQACNRFNCP 729
Score = 119 bits (299), Expect = 7e-27
Identities = 73/248 (29%), Positives = 104/248 (41%), Gaps = 22/248 (8%)
Query: 273 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGREC 331
++Y W+ CS +C GV A C+ E +++ C RP + + C C
Sbjct: 607 ELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
Query: 332 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY--SDLCEAAEAVRPEERKTC 389
RWE WS CS TCG G Q R V C +LS + +V +LC +P + C
Sbjct: 667 PARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQP---KPSTVQAC 723
Query: 390 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEK 439
C P W ++W C+ CG V R++ C + E C ++P ++
Sbjct: 724 NRFNCPPAWYPAQWQPCSRTCG-GGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQ 781
Query: 440 NCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC----KTSDGRVVPESQCQMETKPLAI 495
C C +W +SDW CS SCG+G R C KT VV + C +I
Sbjct: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841
Query: 496 HPCGDKNC 503
PC C
Sbjct: 842 RPCMLATC 849
Score = 118 bits (296), Expect = 2e-26
Identities = 76/246 (30%), Positives = 110/246 (44%), Gaps = 29/246 (11%)
Query: 335 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 394
WE +++CS +CG G Q VV C L+ +LC + P+ K+C C
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSC---LNKQTREPAEENLCVTSRRP-PQLLKSCNLDPC 666
Query: 395 GPQWEMSEWSECTAKCGERSVVTRDIRCSE------------DEKLCDPNTRPVGEKNCT 442
+WE+ +WS C+ CG + TRD+ CS ++LC +P + C
Sbjct: 667 PARWEIGKWSPCSLTCGV-GLQTRDVFCSHLLSREMNETVILADELCR-QPKPSTVQACN 724
Query: 443 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT--SDGRVV--PESQCQMETKPLAIHPC 498
C W + W PCS +CG G R V CK +DG + PE+ C +KP C
Sbjct: 725 RFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPACQQAC 783
Query: 499 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEEST 557
+CP+ WL DW C+T+CG G + R +C + L G + C PP +
Sbjct: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLC-----PPLPFS 838
Query: 558 CFERPC 563
RPC
Sbjct: 839 SSIRPC 844
Score = 104 bits (260), Expect = 2e-22
Identities = 90/340 (26%), Positives = 126/340 (37%), Gaps = 85/340 (25%)
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
RW + + CS TCG GYQ C+ + S + Y E ++P+
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348
Query: 394 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 453
P+ + C A G + ++ D L P R W +
Sbjct: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383
Query: 454 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 509
W CS SCG G R V C D G V V E +C K PC +CP WLA
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442
Query: 510 QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF-ERPCFK--- 565
Q+W C TCG+G++ R+VLC++ + G C KP + C PC+K
Sbjct: 443 QEWSPCTVTCGQGLRYRVVLCID---HRGMHTGG--CSPKTKPHIKEECIVPTPCYKPKE 497
Query: 566 ---------WYTSP-------------------WSECTKTCGVGVRMRDVKCYQGTDIVR 597
W+ WS CT TCGVG ++R V+C +
Sbjct: 498 KLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQ 557
Query: 598 GCDPLV-------KPVGRQACDLQPCPTEPPDDSCQDQPG 630
L KP ++AC PC E P+ + + G
Sbjct: 558 SVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDG 597
Score = 99.0 bits (245), Expect = 1e-20
Identities = 75/283 (26%), Positives = 109/283 (38%), Gaps = 39/283 (13%)
Query: 398 WEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP-----NTRPVGEK-NCTGPPCDRQWT 451
W + + C+A CG R V +RC + +P RP + C C +W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 452 VSDWGPCSGSCGQGRTIRHVYCKT--SDGRVVPESQ---CQMETKPLAIHPCGDKNCPAH 506
V+ W C+ SCG G R V C+ + G P S Q+ +P+ C + C
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC-VE 1609
Query: 507 WLAQDWERCNTTC---GRGVKKRLVLCMELANGKPQTRSG-----PECGLAKKPPEESTC 558
W W +CN C V+ R V C QTR G +C +P C
Sbjct: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFC--------QTRDGITLPSEQCSALPRPVSTQNC 1661
Query: 559 FERPC-FKWYTSPWSECTKTCG-VGVRMRDVKCYQGTDIVRGCDPLV----KPVGRQACD 612
+ C W S W+ CT TCG G + R V+C + L +P Q C+
Sbjct: 1662 WSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCN 1721
Query: 613 LQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 655
+ PC + C+D C ++ LC + CC +C
Sbjct: 1722 ITPC----ENMECRDTT-RYCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 89.4 bits (220), Expect = 1e-17
Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)
Query: 445 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 498
P +W +D+ PCS +CG G + C RVV + C ++ KP + C
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354
Query: 499 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 540
CPA W A W C+++CG G++ R V C+E G +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
Query: 541 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 599
+C K P C C KW WS CT TCG G+R R V C + GC
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 600 DPLVKPVGRQACDLQPCPTEPPDD 623
P KP ++ C + P P P +
Sbjct: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497
Score = 88.2 bits (217), Expect = 2e-17
Identities = 56/181 (30%), Positives = 83/181 (45%), Gaps = 13/181 (7%)
Query: 447 DRQWTVSDWGPCSGSCG-QGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP--CGDKNC 503
D W+V CS SCG +G + C + V P + C + +P A+ P C ++C
Sbjct: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNP-AHCAGKVRP-AVQPIACNRRDC 1545
Query: 504 PAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPEC-GLAKKPPEESTCFER 561
P+ W+ W C +CG GV+ R V C +L A+G S C +AK+P + C ++
Sbjct: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
Query: 562 PCFKWYTSPWSECTKTC---GVGVRMRDVKCYQGTDIV---RGCDPLVKPVGRQACDLQP 615
C +W S W +C C + V+ R V C I C L +PV Q C +
Sbjct: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
Query: 616 C 616
C
Sbjct: 1666 C 1666
Score = 74.3 bits (181), Expect = 3e-13
Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 9/123 (7%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCVRY--DG--VEVDDSYCDALTRPEPVHEFCAGRECQ 332
W + +PCS TC GV +C + DG +E+ +++C A ++P + C +C
Sbjct: 732 WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSA-SKPA-CQQACKKDDCP 789
Query: 333 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA---AEAVRPEERKTC 389
W S W+ECS +CGEG Q R C KML G + V S LC + ++RP TC
Sbjct: 790 SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
Query: 390 RNP 392
P
Sbjct: 850 ARP 852
Score = 37.4 bits (85), Expect = 0.044
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)
Query: 340 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 399
WSECSRTCG G + + RC + S CE R +TC N C P+
Sbjct: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86
Query: 400 MSEWSECTA 408
+C+A
Sbjct: 87 DFRAQQCSA 95
Score = 32.3 bits (72), Expect = 1.4
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 570 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 626
PWSEC++TCG G +C + C+ + + + C CP E D Q
Sbjct: 41 PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 150 bits (378), Expect = 5e-36
Identities = 84/280 (30%), Positives = 127/280 (45%), Gaps = 23/280 (8%)
Query: 395 GPQWEMSEWSECTAKCGERSVVTRDIRCSE-------DEKLCDPNTRPV-GEKNCTGPPC 446
G W WSEC+A C V +++ C CDP+++P ++ C PC
Sbjct: 841 GFTWNHQPWSECSATCAG-GVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
Query: 447 DRQWTVSDWGPCSGSCGQGRTIRHVYC----KTSDGRVVPESQCQMETKPLAIHPCGDKN 502
+W + DW CS +C G R V C S+ + S C + +P+ PC +++
Sbjct: 900 PPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LTHRPVEKEPCNNQS 958
Query: 503 CPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP 562
CP W+A DW C CG G K R+VLC ++ +T +C KPP C
Sbjct: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCK--SSDLSKTFPAAQCPEESKPPVRIRCSLGR 1016
Query: 563 C--FKWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQPCPTE 619
C +W T W +C+ CG+G +MR V+C T C V+P Q C+ C +
Sbjct: 1017 CPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCE-SKCDST 1075
Query: 620 P--PDDSCQD-QPGTNCALAIKVNLCGHWYYSKACCRSCR 656
P + C+D C L +K C Y+ + CC++C+
Sbjct: 1076 PISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 1115
Score = 134 bits (338), Expect = 2e-31
Identities = 74/235 (31%), Positives = 106/235 (45%), Gaps = 13/235 (5%)
Query: 275 YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 333
+ W CSATC GV +C R D V ++YCD ++P C C P
Sbjct: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP 901
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
W W ECS+TC G + R V C + + P + ++ C RP E++ C N +
Sbjct: 902 EWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH---RPVEKEPCNNQS 958
Query: 394 CGPQWEMSEWSECTAKCG----ERSVVTR--DIRCSEDEKLCDPNTRPVGEKNCTGPPC- 446
C PQW +WSECT KCG R V+ + D+ + C ++P C+ C
Sbjct: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
Query: 447 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 501
+W DWG CS CG G+ +R V C + G+ S C +P ++ C K
Sbjct: 1019 PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA--SSDCLETVRPPSMQQCESK 1071
Score = 69.7 bits (169), Expect = 8e-12
Identities = 43/137 (31%), Positives = 62/137 (45%), Gaps = 12/137 (8%)
Query: 492 PLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKK 551
P+ GD W Q W C+ TC GV+++ V+C L + + C K
Sbjct: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNN--YCDPDSK 886
Query: 552 PPE-ESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKCY-------QGTDIVRGCDPL 602
PPE + C PC +W+ W EC+KTC G+R R V C + T GC
Sbjct: 887 PPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGC-LT 945
Query: 603 VKPVGRQACDLQPCPTE 619
+PV ++ C+ Q CP +
Sbjct: 946 HRPVEKEPCNNQSCPPQ 962
Score = 32.0 bits (71), Expect = 1.9
Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 12/76 (15%)
Query: 554 EESTCFERPCFKWYTSP------------WSECTKTCGVGVRMRDVKCYQGTDIVRGCDP 601
E+ C++ C + T P W EC++TCG GV C G
Sbjct: 538 EKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
Query: 602 LVKPVGRQACDLQPCP 617
L + ++C+ PCP
Sbjct: 598 LGERKRYRSCNTDPCP 613
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 146 bits (369), Expect = 5e-35
Identities = 80/276 (28%), Positives = 120/276 (43%), Gaps = 20/276 (7%)
Query: 398 WEMSEWSECTAKC-GERSVVTRDIRCSEDEKLCDPN------TRPVGEKNCTGPPCDRQW 450
W + W++C+A+C G V + R D P+ P ++ C PC W
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDW 888
Query: 451 TVSDWGPCSGSCGQGRTIRHVYCK----TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 506
V +W CS SC G R V C+ ++ + + +S C + +P + C CP
Sbjct: 889 VVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPVLEACHGPTCPPE 947
Query: 507 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--F 564
W A DW C +CG G++ R+VLC + T C A KPP C R C
Sbjct: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHRA--TLPPAHCSPAAKPPATMRCNLRRCPPA 1005
Query: 565 KWYTSPWSECTKTCGVGVRMRDVKCYQGT-DIVRGCDPLVKPVGRQACDLQ---PCPTEP 620
+W W EC+ CGVG R R V+C T C ++P Q C+ + P P +
Sbjct: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDG 1065
Query: 621 PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 656
P++ C L +K C Y+ + CC++C+
Sbjct: 1066 PEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ 1101
Score = 116 bits (290), Expect = 8e-26
Identities = 68/235 (28%), Positives = 94/235 (40%), Gaps = 13/235 (5%)
Query: 275 YRWKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 333
Y W + CSA C G C + D V YC A ++ C C P
Sbjct: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
W +WS CSR+C G + R V C + +S + ++ C RP + C P
Sbjct: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQP---RPPVLEACHGPT 943
Query: 394 CGPQWEMSEWSECTAKCG----ERSVVTR--DIRCSEDEKLCDPNTRPVGEKNCTGPPC- 446
C P+W +WSECT CG R V+ + D R + C P +P C C
Sbjct: 944 CPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP 1003
Query: 447 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDK 501
+W +WG CS CG G+ R V C + G+ +C +P C K
Sbjct: 1004 PARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA--SHECTEALRPPTTQQCEAK 1056
Score = 84.3 bits (207), Expect = 3e-16
Identities = 57/180 (31%), Positives = 75/180 (41%), Gaps = 18/180 (10%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGRECQ 332
W + + CS +C GV S +C R + +DDS C RP PV E C G C
Sbjct: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRP-PVLEACHGPTCP 945
Query: 333 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNP 392
P W WSEC+ +CG G + RVV C D + A +P C
Sbjct: 946 PEWAALDWSECTPSCGPGLRHRVVLC-----KSADHRATLPPAHCSPAAKPPATMRCNLR 1000
Query: 393 ACGP-QWEMSEWSECTAKCGERSVVTRDIRCS----EDEKLCDPNTRPVGEKNCTGPPCD 447
C P +W EW EC+A+CG R +RC+ + C RP + C CD
Sbjct: 1001 RCPPARWVAGEWGECSAQCGV-GQRQRSVRCTSHTGQASHECTEALRPPTTQQCEA-KCD 1058
Score = 40.0 bits (92), Expect = 0.007
Identities = 18/63 (28%), Positives = 33/63 (52%), Gaps = 5/63 (7%)
Query: 562 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTD----IVRGCDPLVK-PVGRQACDLQPC 616
P + W+ +PW++C+ C G +++ V+C D C K P ++AC+ +PC
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 617 PTE 619
P +
Sbjct: 885 PPD 887
Score = 33.1 bits (74), Expect = 0.84
Identities = 15/54 (27%), Positives = 24/54 (44%)
Query: 569 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622
+PW +C++TCG GV C + G L + ++C+ CP D
Sbjct: 554 TPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQD 607
Score = 29.6 bits (65), Expect = 9.3
Identities = 17/49 (34%), Positives = 24/49 (48%), Gaps = 8/49 (16%)
Query: 426 EKLCDP-NTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC 473
+++C P +RP G GP WT WG CS +CG G + +C
Sbjct: 533 KRVCVPFGSRPEGVDGAWGP-----WT--PWGDCSRTCGGGVSSSSRHC 574
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 144 bits (364), Expect = 2e-34
Identities = 90/276 (32%), Positives = 120/276 (43%), Gaps = 24/276 (8%)
Query: 376 EAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEK-----LCD 430
E V E R P+ G W WS+C+A+CG +R + C+ D + +C
Sbjct: 259 EPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQ-SRLVFCTIDHEAYPDHMCQ 317
Query: 431 PNTRPVGEKNCTGPPCD--RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDG----RVVPES 484
RP ++C PC ++W W PCS SCG G R VYC +SDG V E+
Sbjct: 318 RQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEA 377
Query: 485 QCQ-METKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 543
+C + KP AI C + C A W + W C+ +CG GV+KR V C T +
Sbjct: 378 ECAGLPGKPPAIQACNLQRCAA-WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAA- 435
Query: 544 PECGLAKKPPEESTCFERPC-----FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG 598
C L +PP C C W+ W C+K+C G R R V C G G
Sbjct: 436 --CSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCG 493
Query: 599 CDPLVKPVGRQACDLQPC--PTEPPDDSCQDQPGTN 632
KPV + C+ QPC P E P P +N
Sbjct: 494 SLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASN 529
Score = 114 bits (286), Expect = 2e-25
Identities = 76/250 (30%), Positives = 109/250 (43%), Gaps = 40/250 (16%)
Query: 335 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAAEAVRPEERKTCRNPA 393
W SWS+CS CG G+Q R+V C D Y D +C+ RP +R++C
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFC------TIDHEAYPDHMCQ--RQPRPADRRSCNLHP 332
Query: 394 C--GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPP------ 445
C +W+ W+ C+A CG S +R + C + V E C G P
Sbjct: 333 CPETKRWKAGPWAPCSASCGGGS-QSRSVYCISSDGA--GIQEAVEEAECAGLPGKPPAI 389
Query: 446 --CDRQ----WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCG 499
C+ Q W+ WG CS SCG G R V C+ G ++ + C +E +P PC
Sbjct: 390 QACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
Query: 500 DKNCP----AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAK--KPP 553
++CP W W C+ +C G ++R V+C A G P CG + KP
Sbjct: 450 HEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC---AIGPPS-----HCGSLQHSKPV 501
Query: 554 EESTCFERPC 563
+ C +PC
Sbjct: 502 DVEPCNTQPC 511
Score = 99.8 bits (247), Expect = 7e-21
Identities = 74/246 (30%), Positives = 91/246 (36%), Gaps = 22/246 (8%)
Query: 271 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 330
P+ + W S CSA C G S C D D C RP C
Sbjct: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFCT-IDHEAYPDHMCQRQPRPAD-RRSCNLHP 332
Query: 331 CQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT 388
C RW+ W+ CS +CG G Q R V C G +V C A +P +
Sbjct: 333 CPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC-AGLPGKPPAIQA 391
Query: 389 CRNPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCS-EDEKLCDPNTRPVGEKNCTG 443
C C W W EC+ CG +RSV R R S C RP + C
Sbjct: 392 CNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVH 450
Query: 444 PPC----DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQC--QMETKPLAIHP 497
C D+ W V WG CS SC G R V C + P S C +KP+ + P
Sbjct: 451 EDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVIC-----AIGPPSHCGSLQHSKPVDVEP 505
Query: 498 CGDKNC 503
C + C
Sbjct: 506 CNTQPC 511
Score = 72.4 bits (176), Expect = 1e-12
Identities = 104/456 (22%), Positives = 149/456 (32%), Gaps = 91/456 (19%)
Query: 262 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDSYCDALTRP 319
PK R+Q + +W PCS TC GV C R DG S C P
Sbjct: 20 PKVRRQSDTWGPWSQWS-----PCSRTCGGGVSFRERPCYSQRRDG----GSSC---VGP 67
Query: 320 EPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVR----------CWKMLSPGFDSS 369
H C C +C+ G +Q R R C P ++
Sbjct: 68 ARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENF 127
Query: 370 VYSDLCEAAEAVRPEERK-------TCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC 422
Y + E K +CR C + + S+ + +CG C
Sbjct: 128 YYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTT-----C 182
Query: 423 SEDEKLCDPNTRPVGEKNCTGP-PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVV 481
D N KN G + WT+ + + TI H Y + ++G +
Sbjct: 183 YPVAGTFDANDLSRAVKNVRGEYYLNGHWTIE----AARALPAASTILH-YERGAEGDLA 237
Query: 482 PESQCQM--ETKPLAIHPCGDKNCPA----------------HWLAQDWERCNTTCGRGV 523
PE ++PL I + P W W C+ CG G
Sbjct: 238 PERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGH 297
Query: 524 KKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC---FKWYTSPWSECTKTCGV 580
+ RLV C P C +P + +C PC +W PW+ C+ +CG
Sbjct: 298 QSRLVFCTIDHEAYPDHM----CQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGG 353
Query: 581 GVRMRDVKCY--QGTDIVRGCDPLV------KPVGRQACDLQPCPTEPPDDSCQDQPGTN 632
G + R V C G I + KP QAC+LQ C P +P
Sbjct: 354 GSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSP------EPWGE 407
Query: 633 CALAIKVNL------C----GHWYYSKACCRSCRPP 658
C+++ V + C G ++ AC RPP
Sbjct: 408 CSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPP 443
Score = 46.6 bits (109), Expect = 7e-05
Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 6/54 (11%)
Query: 613 LQPCPTEPPDD---SCQDQPG-TNCALAIKVNLCGHWYYSKACCRSCR--PPHS 660
+ P PT P D C DQP NC L ++ LCG+ YYS CC SC PH+
Sbjct: 1193 VSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHA 1246
Score = 37.0 bits (84), Expect = 0.058
Identities = 29/90 (32%), Positives = 37/90 (41%), Gaps = 11/90 (12%)
Query: 548 LAKKPPEESTCFERPCFKWYT-SPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKP 605
LA P + R W S WS C++TCG GV R+ CY Q D G V P
Sbjct: 11 LAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRD---GGSSCVGP 67
Query: 606 V-GRQACDLQPCPTEPPDDSCQDQPGTNCA 634
++C + CP D +D CA
Sbjct: 68 ARSHRSCRTESCP-----DGARDFRAEQCA 92
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 140 bits (353), Expect = 4e-33
Identities = 96/293 (32%), Positives = 121/293 (41%), Gaps = 32/293 (10%)
Query: 378 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPV 436
AEA P + RN W+ WSEC+ CG V R +RCS ++ C P RP
Sbjct: 1399 AEAGPPADPLVVRNAG----WQAGNWSECSTTCG-LGAVWRPVRCSSGRDEDCAPAGRPQ 1453
Query: 437 GEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQM-ETKPLA 494
+ C PC W +W CS SCG G ++R V C T D R + CQ KP A
Sbjct: 1454 PARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPA 1512
Query: 495 IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKK 551
PCG + C + W W C+ CG G ++RLV C PE GL A +
Sbjct: 1513 HRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTC-------------PEPGLCEEALR 1558
Query: 552 PPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQ-----GTDIVRGCDPLVKPV 606
P C PC +W PW +C+ CG GV+ R VKC + C P
Sbjct: 1559 PNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPE 1618
Query: 607 GRQACDLQPC-PTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPP 658
+ C + C P EPP C + C CCRSC PP
Sbjct: 1619 SSRPCGTEDCEPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPP 1671
Score = 124 bits (310), Expect = 4e-28
Identities = 78/238 (32%), Positives = 102/238 (42%), Gaps = 33/238 (13%)
Query: 335 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 394
W+ +WSECS TCG G +R VRC S G D + A A RP+ + C C
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRC----SSGRDE-------DCAPAGRPQPARRCHLRPC 1463
Query: 395 GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL-------CDPN-TRPVGEKNCTGPPC 446
W WS+C+ CG S V RD++C + L C P +P + C PC
Sbjct: 1464 A-TWHSGNWSKCSRSCGGGSSV-RDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
Query: 447 DRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPE-SQCQMETKPLAIHPCGDKNCPA 505
W S W CS +CG G R V C PE C+ +P PC C
Sbjct: 1522 -LSWYTSSWRECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNTHPC-T 1571
Query: 506 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 563
W+ W +C+ CG GV++RLV C+ G P+ S +CG P C C
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDS-DQCGHEAWPESSRPCGTEDC 1628
Score = 105 bits (263), Expect = 1e-22
Identities = 87/282 (30%), Positives = 112/282 (39%), Gaps = 30/282 (10%)
Query: 235 SSEAPFPN--VSTSLLTSAGNRTHKARTRPKARK--QGVSPADMY-----RWKLSSHEPC 285
S E P + +ST S N T+P A + PAD W+ + C
Sbjct: 1364 SPEVPLSSRLLSTPAWDSPANSHRVPETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSEC 1423
Query: 286 SATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSR 345
S TC G + C D C RP+P C R C W + +WS+CSR
Sbjct: 1424 STTCGLGAVWRPVRC-----SSGRDEDCAPAGRPQPARR-CHLRPC-ATWHSGNWSKCSR 1476
Query: 346 TCGEGYQFRVVRC--WKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEW 403
+CG G R V+C + L P + C+ A P R P W S W
Sbjct: 1477 SCGGGSSVRDVQCVDTRDLRP-----LRPFHCQPGPAKPPAHRPCGAQPCL--SWYTSSW 1529
Query: 404 SECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCG 463
EC+ CG R + C E LC+ RP + C PC QW V WG CSG CG
Sbjct: 1530 RECSEACG-GGEQQRLVTCPE-PGLCEEALRPNTTRPCNTHPC-TQWVVGPWGQCSGPCG 1586
Query: 464 QGRTIRHVYCKTSDGRVVPE--SQCQMETKPLAIHPCGDKNC 503
G R V C + + E QC E P + PCG ++C
Sbjct: 1587 GGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 103 bits (256), Expect = 7e-22
Identities = 57/178 (32%), Positives = 82/178 (46%), Gaps = 7/178 (3%)
Query: 444 PPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPL-AIHPCGDKN 502
PP W W C+ +CG+G ++VYC V E C +P C ++
Sbjct: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878
Query: 503 CPAHWLAQDWERCNTTCGRG-VKKRLVLCMELANGKPQTR-SGPECGLAKKPPEESTCFE 560
CPA W A +W+ C+++CG G + +R VLC+ Q+ P C +PP E+ C
Sbjct: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
Query: 561 R-PC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 616
PC W WS+C+ TCG G + R+V C T + CD +P C L C
Sbjct: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGV--PCDEAQQPASEVTCSLPLC 994
Score = 102 bits (255), Expect = 9e-22
Identities = 57/196 (29%), Positives = 83/196 (42%), Gaps = 8/196 (4%)
Query: 271 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 330
P ++ W C+ TC GV C+ VD+ +CD L RP+ C+ +
Sbjct: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878
Query: 331 CQPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 389
C RW W CS +CG G R V C + + S++ CE RP C
Sbjct: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACE--HLPRPPTETPC 936
Query: 390 -RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL-CDPNTRPVGEKNCTGPPCD 447
R+ C W + WS+C+ CGE R++ C+ D + CD +P E C+ P C
Sbjct: 937 NRHVPCPATWAVGNWSQCSVTCGE-GTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLC- 994
Query: 448 RQWTVSDWGPCSGSCG 463
+W + GP G
Sbjct: 995 -RWPLGTLGPEGSGSG 1009
Score = 101 bits (252), Expect = 2e-21
Identities = 61/193 (31%), Positives = 88/193 (45%), Gaps = 18/193 (9%)
Query: 431 PNTRPVGEKNC-TGPPCD------RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPE 483
P T+P+ GPP D W +W CS +CG G R V C S GR +
Sbjct: 1389 PETQPLAPSLAEAGPPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC--SSGR---D 1443
Query: 484 SQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSG 543
C +P C + C A W + +W +C+ +CG G R V C++ + +P
Sbjct: 1444 EDCAPAGRPQPARRCHLRPC-ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFH 1502
Query: 544 PECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLV 603
+ G AK PP C +PC WYTS W EC++ CG G + R V C + C+ +
Sbjct: 1503 CQPGPAK-PPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPE----PGLCEEAL 1557
Query: 604 KPVGRQACDLQPC 616
+P + C+ PC
Sbjct: 1558 RPNTTRPCNTHPC 1570
Score = 100 bits (249), Expect = 4e-21
Identities = 60/182 (32%), Positives = 83/182 (45%), Gaps = 23/182 (12%)
Query: 398 WEMSEWSECTAKCGERSVVTRDIRCSE------DEKLCDPNTRPVGE-KNCTGPPCDRQW 450
W W++CT CG R V +++ C E DE+ CDP RP + + C+ PC +W
Sbjct: 825 WHYGPWTKCTVTCG-RGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
Query: 451 TVSDWGPCSGSCGQGRTIRH-VYCKTSDG----RVVPESQCQMETKPLAIHPCGDK-NCP 504
+W CS SCG G R V C S G + C+ +P PC CP
Sbjct: 884 WAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCP 943
Query: 505 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 564
A W +W +C+ TCG G ++R VLC +G C A++P E TC P
Sbjct: 944 ATWAVGNWSQCSVTCGEGTQRRNVLC--------TNDTGVPCDEAQQPASEVTC-SLPLC 994
Query: 565 KW 566
+W
Sbjct: 995 RW 996
Score = 55.5 bits (132), Expect = 2e-07
Identities = 26/60 (43%), Positives = 35/60 (58%), Gaps = 4/60 (6%)
Query: 562 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQ---GTDIVRGCDPLVKPVGRQ-ACDLQPCP 617
P F W+ PW++CT TCG GV+ ++V C + G CDPL +P +Q C QPCP
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Score = 45.8 bits (107), Expect = 1e-04
Identities = 36/137 (26%), Positives = 45/137 (32%), Gaps = 19/137 (13%)
Query: 262 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 321
P R G P W SS CS C G C + C+ RP
Sbjct: 1511 PAHRPCGAQPC--LSWYTSSWRECSEACGGGEQQRLVTCP-------EPGLCEEALRPNT 1561
Query: 322 VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS--PGFDSSVYSDLCEAAE 379
C C +W W +CS CG G Q R+V+C + P DS +
Sbjct: 1562 TRP-CNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSD------QCGH 1613
Query: 380 AVRPEERKTCRNPACGP 396
PE + C C P
Sbjct: 1614 EAWPESSRPCGTEDCEP 1630
Score = 38.9 bits (89), Expect = 0.015
Identities = 18/53 (33%), Positives = 30/53 (56%)
Query: 569 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 621
S WS C+++CG+GV+ + +C Q T +G + + + C+LQ CP P
Sbjct: 545 SAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRP 597
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 140 bits (352), Expect = 5e-33
Identities = 81/242 (33%), Positives = 110/242 (45%), Gaps = 18/242 (7%)
Query: 270 SPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---VDDSYCDALTRPEPVHEFC 326
+P ++ W +S E C ATC G C + VD+ C LT+PEP C
Sbjct: 912 APEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKC 971
Query: 327 AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAE----AVR 382
+ CQ RW + W+ CSRTCG+G Q R V C + LS G L A E +
Sbjct: 972 NEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNG-------TLIRARERDCIGPK 1024
Query: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCT 442
P + C C WE WSEC+ KCG + + R +RC+ K C +TRP ++C
Sbjct: 1025 PASAQRCEGQDCMTVWEAGVWSECSVKCG-KGIRHRTVRCTNPRKKCVLSTRPREAEDCE 1083
Query: 443 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIHPCGDK 501
W + DW CS +CG+G R + C GR ++C KP A PC +
Sbjct: 1084 DYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGR--HGNECFSSEKPAAYRPCHLQ 1141
Query: 502 NC 503
C
Sbjct: 1142 PC 1143
Score = 133 bits (335), Expect = 5e-31
Identities = 75/256 (29%), Positives = 117/256 (45%), Gaps = 26/256 (10%)
Query: 320 EPVHEFCAGRECQP--RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
+P+ E + + +P W +SW +C TCG G + V C K++S S V ++ C+
Sbjct: 902 DPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNI-SIVDNEKCKY 960
Query: 378 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSED----------EK 427
P+ RK C C +W M+EW+ C+ CG + + +R + C++ E+
Sbjct: 961 LTKPEPQIRK-CNEQPCQTRWMMTEWTPCSRTCG-KGMQSRQVACTQQLSNGTLIRARER 1018
Query: 428 LCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQ 487
C +P + C G C W W CS CG+G R V C P +C
Sbjct: 1019 DCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN------PRKKCV 1071
Query: 488 METKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 547
+ T+P C D + W DW +C+ TCG+G++ R++ CM G R G EC
Sbjct: 1072 LSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG----RHGNECF 1127
Query: 548 LAKKPPEESTCFERPC 563
++KP C +PC
Sbjct: 1128 SSEKPAAYRPCHLQPC 1143
Score = 133 bits (334), Expect = 6e-31
Identities = 86/302 (28%), Positives = 136/302 (45%), Gaps = 41/302 (13%)
Query: 385 ERKTCRNPACGPQWEMSEWSECTAKCG--ERS-------VVTRDIRCSEDEKLCDPNTRP 435
E ++ + P W + W +C A CG ER +++++I ++EK C T+P
Sbjct: 906 ENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEK-CKYLTKP 964
Query: 436 VGE-KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC--KTSDGRVVP--ESQCQMET 490
+ + C PC +W +++W PCS +CG+G R V C + S+G ++ E C +
Sbjct: 965 EPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC-IGP 1023
Query: 491 KPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAK 550
KP + C ++C W A W C+ CG+G++ R V C T +C L+
Sbjct: 1024 KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC---------TNPRKKCVLST 1074
Query: 551 KPPEESTCFE-RPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVG 607
+P E C + C+ W WS+C+ TCG G++ R ++C G C KP
Sbjct: 1075 RPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAA 1134
Query: 608 RQACDLQPCP--------TEP-----PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRS 654
+ C LQPC T P DQ C + + NLC + + CC +
Sbjct: 1135 YRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCET 1194
Query: 655 CR 656
CR
Sbjct: 1195 CR 1196
Score = 47.0 bits (110), Expect = 6e-05
Identities = 92/376 (24%), Positives = 132/376 (35%), Gaps = 96/376 (25%)
Query: 324 EFCAGRECQPRW--------ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 375
++C EC R E S WS CSRTC G R +C PG DS
Sbjct: 618 KWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC-----PGLDS------- 665
Query: 376 EAAEAVRPEER-KTCRN---PACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP 431
EA + P ++ + C N PA P + + + + + + ++EK C
Sbjct: 666 EARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCAL 725
Query: 432 NTRPVG--------EKNCTGPPCDRQWT-VSDWGPCS--GSCGQ-GRTIRHVYCKTSDGR 479
PVG EK G C Q + G C G G G R +C +G
Sbjct: 726 FCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGN 785
Query: 480 -----------------------VVPESQCQM---ETKP----LAIHPCGDKNCPAHWLA 509
V+P ++ E KP LA+ G ++ + W
Sbjct: 786 GKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKI 845
Query: 510 QD---WERCNTTCG---RGVKKR-------------LVLCMELAN-GKPQTRSGPECGLA 549
+ + TT RG+ ++ LVL + N G + P L
Sbjct: 846 EHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPL- 904
Query: 550 KKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC----YQGTDIV--RGCDPLV 603
P +S+ P F W + W +C TCG G R V C + IV C L
Sbjct: 905 --PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT 962
Query: 604 KPVGR-QACDLQPCPT 618
KP + + C+ QPC T
Sbjct: 963 KPEPQIRKCNEQPCQT 978
Score = 37.0 bits (84), Expect = 0.058
Identities = 27/92 (29%), Positives = 39/92 (42%), Gaps = 12/92 (13%)
Query: 543 GPECGLAK-----KPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVR 597
G +C L K + ++ E +W S WS C++TC G+ R+ KC R
Sbjct: 611 GTDCDLGKWCKAGECTSRTSAPEHLAGEW--SLWSPCSRTCSAGISSRERKCPGLDSEAR 668
Query: 598 GCDPLVKPVGRQACDLQPCPTEPP---DDSCQ 626
C+ K + C+ PCP P D CQ
Sbjct: 669 DCNGPRKQY--RICENPPCPAGLPGFRDWQCQ 698
Score = 30.0 bits (66), Expect = 7.1
Identities = 12/42 (28%), Positives = 19/42 (45%)
Query: 260 TRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCV 301
TRP+ + + Y W++ CS TC G+ S C+
Sbjct: 1074 TRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCM 1115
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 138 bits (347), Expect = 2e-32
Identities = 100/374 (26%), Positives = 148/374 (39%), Gaps = 62/374 (16%)
Query: 273 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEV------------------------ 308
D +W C+ TC G+ +C+ + G V
Sbjct: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
Query: 309 -DDSYCDA----LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLS 363
+ S +A L + + + E E +P + WS CS TCG G Q R V+C +L+
Sbjct: 538 KEKSPVEAKLPWLKQAQELEETRIATE-EPTFIPEPWSACSTTCGPGVQVREVKCRVLLT 596
Query: 364 -PGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ-------------------WEMSEW 403
++ + + CE + P ER C AC WE + +
Sbjct: 597 FTQTETELPEEECEGPKL--PTERP-CLLEACDESPASRELDIPLPEDSETTYDWEYAGF 653
Query: 404 SECTAKC----GERSVVTRDIRCSE--DEKLCDPNTRPVG-EKNCTGPPCDRQWTVSDWG 456
+ CTA C E V I+ + ++ LCD RP + C PC +W V WG
Sbjct: 654 TPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713
Query: 457 PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCN 516
PCS +CG G R VYC P +C+ E KP A+ C +CP W ++W++C+
Sbjct: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDE-KPHALQACNQFDCPPGWHIEEWQQCS 772
Query: 517 TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-TSPWSECT 575
TCG G + R V C +L E K +C C WS+C+
Sbjct: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
Query: 576 KTCGVGVRMRDVKC 589
+CGVG++ R C
Sbjct: 833 VSCGVGIQRRKQVC 846
Score = 130 bits (326), Expect = 5e-30
Identities = 83/242 (34%), Positives = 109/242 (45%), Gaps = 11/242 (4%)
Query: 268 GVSPADMYRWKLSSHEPCSATCT-TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFC 326
G P W+ + CSATC G CV +G EV ++ CD L +P E C
Sbjct: 1419 GEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPC 1478
Query: 327 AGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEER 386
R+C RW TS WS+CS +CGEGY R V C + + G V C A RP R
Sbjct: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC--APKDRPLGR 1536
Query: 387 KTCRNPACGPQWEMSEWSECTAKCGERSV--VTRDIRC--SEDEKLCDPNTRPVGEKNCT 442
K C C QWE + C +C R+V R C + + CD RP +NCT
Sbjct: 1537 KPCFGHPC-VQWEPG--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCT 1593
Query: 443 GPPCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAIHPCGDK 501
CD W W PC+ +CG+G R V C T + V + C + KP++ C
Sbjct: 1594 SGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
Query: 502 NC 503
+C
Sbjct: 1654 SC 1655
Score = 126 bits (316), Expect = 7e-29
Identities = 114/453 (25%), Positives = 171/453 (37%), Gaps = 106/453 (23%)
Query: 259 RTRPKARKQGVSPADMYR-----WKLSSHEPCSATCTTGVMSAYAMCV--RYDGVEVDDS 311
+TR A K V Y+ W+ + PC+ TC G A CV R V V D
Sbjct: 320 KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRV-VPDH 378
Query: 312 YCDAL---TRPEPVHEFCAGRECQ-----------------PRWETSSWSECSRTCGEGY 351
YC +P+P + C+ C PRWE + W+ CS +CG G
Sbjct: 379 YCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGI 438
Query: 352 QFRVVRCWKMLSPGFDSSVYSDLCEAAE-----AVRPEERKTCRNPACGPQWEMSEWSEC 406
Q R C + S++ ++ + E A +P+ +TC C P+W EWS+C
Sbjct: 439 QRRSFVC-------VEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQC 490
Query: 407 TAKCGERSVVTRDIRC----SEDEKLCDPNTRPVGEKNCTGP-PC--------------- 446
T CG R + R + C E C+P + ++ C P PC
Sbjct: 491 TVTCG-RGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPW 549
Query: 447 ---------------DRQWTVSDWGPCSGSCGQGRTIRHVYCK-----TSDGRVVPESQC 486
+ + W CS +CG G +R V C+ T +PE +C
Sbjct: 550 LKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEEC 609
Query: 487 Q----METKPLAIHPCG--------------DKNCPAHWLAQDWERCNTTCGRGVKKRLV 528
+ +P + C D W + C TC G ++ +
Sbjct: 610 EGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIA 669
Query: 529 LCMELANGKPQTRSGPECGLAKKPPEES-TCFERPC-FKWYTSPWSECTKTCGVGVRMRD 586
+C+ + QT + C + +PP S C PC +W+ W C+ TCGVG++ RD
Sbjct: 670 VCLHIQT--QQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRD 727
Query: 587 VKCYQGTDIVRGCDPL--VKPVGRQACDLQPCP 617
V C + + KP QAC+ CP
Sbjct: 728 VYCLHPGETPAPPEECRDEKPHALQACNQFDCP 760
Score = 123 bits (308), Expect = 6e-28
Identities = 72/230 (31%), Positives = 101/230 (43%), Gaps = 20/230 (8%)
Query: 275 YRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALTRPEPVHEFCAGRECQP 333
Y W+ + PC+ATC G A A+C+ + V+DS CD + RP + + C C P
Sbjct: 646 YDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPP 705
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
RW SW CS TCG G Q R V C L PG ++ + C +P + C
Sbjct: 706 RWHVGSWGPCSATCGVGIQTRDVYC---LHPG-ETPAPPEECRDE---KPHALQACNQFD 758
Query: 394 CGPQWEMSEWSECTAKCGE---------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP 444
C P W + EW +C+ CG R ++T + ++LC + K+C
Sbjct: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ-GPKASSHKSCART 817
Query: 445 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCK--TSDGRVVPESQCQMETKP 492
C V DW CS SCG G R C+ + GR +P S+ P
Sbjct: 818 DCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLP 867
Score = 116 bits (291), Expect = 6e-26
Identities = 92/375 (24%), Positives = 149/375 (39%), Gaps = 66/375 (17%)
Query: 276 RWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVDDSYCDALTRPEPVHEFCAGREC 331
RW+ + CS +C G+ +CV + ++V++ C +P+ V + C +C
Sbjct: 421 RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPK-VMQTCNLFDC 479
Query: 332 QPRWETSSWSECSRTCGEGYQFRVVRCWKM-------LSPGFDSSVYSDLCEAAEAVRPE 384
P+W WS+C+ TCG G ++RVV C +P + + +P+
Sbjct: 480 -PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPK 538
Query: 385 ERKT--CRNPACGPQWEMSE--------------WSECTAKCGERSVVTRDIRCSE---- 424
E+ + P E+ E WS C+ CG V R+++C
Sbjct: 539 EKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP-GVQVREVKCRVLLTF 597
Query: 425 -------DEKLCD----PNTRPVGEKNCTGPPCDRQ--------------WTVSDWGPCS 459
E+ C+ P RP + C P R+ W + + PC+
Sbjct: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657
Query: 460 GSCGQGRTIRHVYC-KTSDGRVVPESQCQMETKPLAI-HPCGDKNCPAHWLAQDWERCNT 517
+C G C + V +S C M +P A+ C + CP W W C+
Sbjct: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSA 717
Query: 518 TCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTK 576
TCG G++ R V C+ +T + PE +KP C + C W+ W +C++
Sbjct: 718 TCGVGIQTRDVYCLHPG----ETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSR 773
Query: 577 TCGVGVRMRDVKCYQ 591
TCG G + R V C Q
Sbjct: 774 TCGGGTQNRRVTCRQ 788
Score = 107 bits (268), Expect = 3e-23
Identities = 78/287 (27%), Positives = 103/287 (35%), Gaps = 79/287 (27%)
Query: 435 PVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ-GRTIRHVYCKTSDGRVVPESQCQMETKPL 493
P GE PP + W +W CS +CG G I+ C ++G+ V E+ C KPL
Sbjct: 1417 PTGEP----PPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPL 1472
Query: 494 A-IHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQTRSGPECGLAKK 551
A PC ++CPA W W +C+ +CG G R V C ANG Q S C +
Sbjct: 1473 AGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDR 1532
Query: 552 PPEESTCF-------------------------------------------ERPCFK--- 565
P CF +RP +
Sbjct: 1533 PLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNC 1592
Query: 566 --------WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVK--------PVGRQ 609
W+T PW CT CG G + R V C R C P+ K P+ +
Sbjct: 1593 TSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIH----TRSCKPVAKRHCVQKKKPISWR 1648
Query: 610 ACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 656
C C D C D C +NLC Y + CC+SC+
Sbjct: 1649 HCLGPSC-----DRDCTDTTHY-CMFVKHLNLCSLDRYKQRCCQSCQ 1689
Score = 106 bits (264), Expect = 8e-23
Identities = 73/280 (26%), Positives = 112/280 (40%), Gaps = 35/280 (12%)
Query: 285 CSATCTTGVMSAYAMC-----VRYDGVEVDDSYCDALTRP-------EPVHEFCAGRECQ 332
CS TC GV C E+ + C+ P E E A RE
Sbjct: 576 CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELD 635
Query: 333 ---PR-------WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 382
P WE + ++ C+ TC G+Q + C + + +V LC+
Sbjct: 636 IPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQT---QQTVNDSLCDMVHRP- 691
Query: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDP-----NTRPVG 437
P + C C P+W + W C+A CG + TRD+ C + P + +P
Sbjct: 692 PAMSQACNTEPCPPRWHVGSWGPCSATCGV-GIQTRDVYCLHPGETPAPPEECRDEKPHA 750
Query: 438 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT--SDGRVVPESQCQMETKPLAI 495
+ C C W + +W CS +CG G R V C+ +DG + S + +
Sbjct: 751 LQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASS 810
Query: 496 HP-CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 534
H C +CP H DW +C+ +CG G+++R +C LA
Sbjct: 811 HKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLA 850
Score = 89.4 bits (220), Expect = 1e-17
Identities = 61/205 (29%), Positives = 93/205 (45%), Gaps = 29/205 (14%)
Query: 445 PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQ-----METKPLAIHPC 498
P QW +D+ PC+ +CG G + C RVVP+ C ++ KP + C
Sbjct: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKP-KLKEC 396
Query: 499 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMELA-NGKPQT 540
CP+ W W C+ +CG G+++R +C+E + +G+
Sbjct: 397 SMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQ 456
Query: 541 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIVRG 598
+C A KP TC C KW WS+CT TCG G+R R V C ++G + V G
Sbjct: 457 VEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRG-EHVGG 515
Query: 599 CDPLVKPVGRQACDLQPCPTEPPDD 623
C+P +K ++ C + P P P +
Sbjct: 516 CNPQLKLHIKEECVI-PIPCYKPKE 539
Score = 58.9 bits (141), Expect = 1e-08
Identities = 52/187 (27%), Positives = 72/187 (38%), Gaps = 23/187 (12%)
Query: 276 RWKLSSHEPCSATCTTGVMSAYAMCVRYDG----VEVDDSYCDALTRPEPVHEFCAGREC 331
RW S CS +C G S C R V C RP + C G C
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPC 1544
Query: 332 QPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 391
+WE + C C R VR + + +S S+ C+ + RP R+ C +
Sbjct: 1545 V-QWEPGN--RCPGRC----MGRAVRMQQRHTACQHNSSDSN-CD--DRKRPTLRRNCTS 1594
Query: 392 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-------EKLCDPNTRPVGEKNCTGP 444
AC W W CTA CG R +R + C ++ C +P+ ++C GP
Sbjct: 1595 GACDVCWHTGPWKPCTAACG-RGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGP 1653
Query: 445 PCDRQWT 451
CDR T
Sbjct: 1654 SCDRDCT 1660
Score = 36.6 bits (83), Expect = 0.076
Identities = 23/75 (30%), Positives = 30/75 (40%), Gaps = 16/75 (21%)
Query: 335 WET-SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
W+ WS+CSRTCG G + + RC + CE KTC N
Sbjct: 78 WDAWGDWSDCSRTCGGGASYSLRRC-----------LTGRNCEGQNI----RYKTCSNHD 122
Query: 394 CGPQWEMSEWSECTA 408
C P E +C+A
Sbjct: 123 CPPDAEDFRAQQCSA 137
Score = 35.0 bits (79), Expect = 0.22
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 11/76 (14%)
Query: 571 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPG 630
WS+C++TCG G +C G R C+ + + + C CP + D Q
Sbjct: 84 WSDCSRTCGGGASYSLRRCLTG----RNCEG--QNIRYKTCSNHDCPPDAEDFRAQ---- 133
Query: 631 TNCALAIKVNLCGHWY 646
C+ V GH+Y
Sbjct: 134 -QCSAYNDVQYQGHYY 148
Score = 31.6 bits (70), Expect = 2.4
Identities = 23/95 (24%), Positives = 34/95 (35%), Gaps = 16/95 (16%)
Query: 500 DKNCPAHWLAQ-DWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 558
D++ +W A DW C+ TCG G L C+ N + Q C PP+
Sbjct: 71 DEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDF 130
Query: 559 FERPC------------FKW---YTSPWSECTKTC 578
+ C ++W Y P + C C
Sbjct: 131 RAQQCSAYNDVQYQGHYYEWLPRYNDPAAPCALKC 165
Score = 29.6 bits (65), Expect = 9.3
Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 19/86 (22%)
Query: 259 RTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTR 318
R RP R+ S A W +PC+A C G S C+ TR
Sbjct: 1583 RKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIH--------------TR 1628
Query: 319 P-EPVHEFCAGRECQPRWETSSWSEC 343
+PV A R C + + SW C
Sbjct: 1629 SCKPV----AKRHCVQKKKPISWRHC 1650
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 137 bits (345), Expect = 3e-32
Identities = 85/256 (33%), Positives = 112/256 (43%), Gaps = 17/256 (6%)
Query: 253 NRTHKARTRPKARKQGVSPAD-MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE---V 308
NRT + ++ P+ P D ++ W S E CS C G C R V
Sbjct: 785 NRTAENQSEPE------KPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLV 838
Query: 309 DDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDS 368
+DS C +RPEP C CQ RW WS CS TC +G+Q R V C L G
Sbjct: 839 NDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHV 898
Query: 369 SVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL 428
+ C RP ++C C WE SEWS+C+A CG + V R + C+ +
Sbjct: 899 ATRPLYCPGP---RPAAVQSCEGQDCLSIWEASEWSQCSASCG-KGVWKRTVACTNSQGK 954
Query: 429 CDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQ 487
CD +TRP E+ C +W DW CS +CG+G R V C GR S+C
Sbjct: 955 CDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR--HGSECP 1012
Query: 488 METKPLAIHPCGDKNC 503
+KP C + C
Sbjct: 1013 ALSKPAPYRQCYQEVC 1028
Score = 131 bits (330), Expect = 2e-30
Identities = 75/238 (31%), Positives = 103/238 (43%), Gaps = 22/238 (9%)
Query: 335 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 394
W S W CS CG G + +V C ++++ SD C A P+ R+ C C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSD-CPQASRPEPQVRR-CNLHPC 861
Query: 395 GPQWEMSEWSECTAKCGERSVVTRDIRCSED---------EKLCDPNTRPVGEKNCTGPP 445
+W WS C+A C E+ R++ C L P RP ++C G
Sbjct: 862 QSRWVAGPWSPCSATC-EKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQD 920
Query: 446 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 505
C W S+W CS SCG+G R V C S G+ C T+P A C D +
Sbjct: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK------CDASTRPRAEEACEDYSGCY 974
Query: 506 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 563
W DW C++TCG+G++ R+V CM G R G EC KP C++ C
Sbjct: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTG----RHGSECPALSKPAPYRQCYQEVC 1028
Score = 126 bits (317), Expect = 6e-29
Identities = 82/287 (28%), Positives = 127/287 (44%), Gaps = 37/287 (12%)
Query: 398 WEMSEWSECTAKCG---ERSVV--TRDIRCSE---DEKLCDPNTRPVGE-KNCTGPPCDR 448
W S W C+ +CG R++V TR + + ++ C +RP + + C PC
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 449 QWTVSDWGPCSGSCGQGRTIRHVYC--KTSDGRVVPESQCQME-TKPLAIHPCGDKNCPA 505
+W W PCS +C +G R V C + +G V +P A+ C ++C +
Sbjct: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLS 923
Query: 506 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERP-CF 564
W A +W +C+ +CG+GV KR V C T S +C + +P E C + C+
Sbjct: 924 IWEASEWSQCSASCGKGVWKRTVAC---------TNSQGKCDASTRPRAEEACEDYSGCY 974
Query: 565 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG--CDPLVKPVGRQACDLQPCP----- 617
+W T WS C+ TCG G++ R V+C G C L KP + C + C
Sbjct: 975 EWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRINA 1034
Query: 618 ---TEP-----PDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCR 656
T P +DQ C + + NLC + + CC++CR
Sbjct: 1035 NTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCR 1081
Score = 38.1 bits (87), Expect = 0.026
Identities = 21/59 (35%), Positives = 24/59 (40%), Gaps = 3/59 (5%)
Query: 571 WSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP---DDSCQ 626
WS C++TCG G R R KC G V C+ PCP P D CQ
Sbjct: 552 WSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQ 610
Score = 35.4 bits (80), Expect = 0.17
Identities = 88/387 (22%), Positives = 138/387 (35%), Gaps = 89/387 (22%)
Query: 304 DGVEVD-DSYCDA--LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWK 360
DG E D +C A P+ E G + P W +WS CSRTCG G +FR +C
Sbjct: 517 DGTECGADKWCRAGECVSKTPIPEHVDG-DWSP-W--GAWSMCSRTCGTGARFRQRKC-D 571
Query: 361 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTA----KCGERSVV 416
PG + C A E C N C +C A ++ ++
Sbjct: 572 NPPPGPGGT----HCPGASV----EHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLL 623
Query: 417 TRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC----SGSCGQGRTIRHVY 472
T + D+K C+ P+G+++ P V D PC + C G+ + +
Sbjct: 624 TAVV---VDDKPCELYCSPLGKES----PLLVADRVLDGTPCGPYETDLCVHGK-CQKIG 675
Query: 473 CKTSDGRVVPESQCQM----------------ETKPLAIHPCGDKNCPAHW---LAQDWE 513
C G E +C + + A+ G + + W L +++
Sbjct: 676 CDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQ 735
Query: 514 RCNTTCGRGVKKRLVLCMELANGKPQTR----------SGPECGL-------AKKPPEES 556
TT R V++ L E + K T+ + G+ + E
Sbjct: 736 IAGTTV-RYVRRGL---WEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQ 791
Query: 557 TCFERP---CFKWYTSPWSECTKTCGVGVRMRDVKC----YQGTDIVR--GCDPLVKPVG 607
+ E+P F W S W C+ CG G R V C + T +V C +P
Sbjct: 792 SEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEP 851
Query: 608 R-QACDLQPC-------PTEPPDDSCQ 626
+ + C+L PC P P +C+
Sbjct: 852 QVRRCNLHPCQSRWVAGPWSPCSATCE 878
Score = 29.6 bits (65), Expect = 9.3
Identities = 50/228 (21%), Positives = 68/228 (29%), Gaps = 62/228 (27%)
Query: 323 HEFCAGRE--CQPRWETS------SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDL 374
H CAGR W SWS CSR E + + S +
Sbjct: 403 HSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENF------------------LKSKV 444
Query: 375 CEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIR---CS------ED 425
P + T R P P S +C G + R++ C+ E
Sbjct: 445 STCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEG 504
Query: 426 EKLC----DP---NTRPVGEKNCTGPPCDRQWTV-----SDWGP------CSGSCGQGRT 467
+ C DP T +K C C + + DW P CS +CG G
Sbjct: 505 DTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGAR 564
Query: 468 IRHVYCKT---------SDGRVVPESQCQMETKPLAIHPCGDKNCPAH 506
R C G V + C+ P + D+ C AH
Sbjct: 565 FRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAH 612
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 124 bits (312), Expect = 2e-28
Identities = 106/422 (25%), Positives = 155/422 (36%), Gaps = 67/422 (15%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCVRYDGV---EVDDSYCDA-LTRPEPVHEFCAGRECQ 332
W + PCSA+C G+ CV G + + C A +P E C + C
Sbjct: 715 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
Query: 333 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE--ERKTCR 390
RWE S S C+ G G C PG D + + + E +V + + C
Sbjct: 775 ARWEVSEPSSCTSAGGAGLALENETC----VPGADG-LEAPVTEGPGSVDEKLPAPEPCV 829
Query: 391 NPACGPQW-----------EMSEWSE-----------------CTAKCGERSVVTR---- 418
+C P W S W C+ CG + R
Sbjct: 830 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 889
Query: 419 --DIRCSEDEKLCDPNTRPVGEKN-CTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT 475
+R E+LC ++P + C PC +W CS SCG+G R +YC
Sbjct: 890 DSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYK-LAACSVSCGRGVVRRILYCAR 948
Query: 476 SDGR-----VVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLC 530
+ G ++ ++QCQ +P C + CP W C+ +CG G +R V C
Sbjct: 949 AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVAC 1008
Query: 531 MELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC 589
++L G+ C +P C C ++W+ W EC+ +CG G++ R C
Sbjct: 1009 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1068
Query: 590 Y----QGTDIVRGCDPLVKPVGRQACDLQPC---------PTEPPDDSCQDQPG-TNCAL 635
Q C L KPV + C PC EP PG +CA+
Sbjct: 1069 LGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAV 1128
Query: 636 AI 637
AI
Sbjct: 1129 AI 1130
Score = 116 bits (291), Expect = 6e-26
Identities = 110/409 (26%), Positives = 152/409 (37%), Gaps = 57/409 (13%)
Query: 260 TRPKARKQGVSPADMYRWKLSS-HEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALT 317
TRP P W ++ PCS +C G+ C+ E V+ C
Sbjct: 638 TRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQ 697
Query: 318 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
+P E C C P W + CS +CG G + R VRC + ++ C A
Sbjct: 698 QPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE-AQGSLLKTLPPARCRA 756
Query: 378 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC--------------- 422
+TC C +WE+SE S CT+ G + + C
Sbjct: 757 GAQQPAVALETCNPQPCPARWEVSEPSSCTS-AGGAGLALENETCVPGADGLEAPVTEGP 815
Query: 423 -SEDEKL----------CDP-----NTRPVGEKN-------CTGPPCDRQWTVSDWGPCS 459
S DEKL C P + GEK TG WT + G CS
Sbjct: 816 GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAA-GSCS 874
Query: 460 GSCGQGRTIRHVYCKTSDGRV-VPESQCQMETKPLAIHP-CGDKNCPAHWLAQDWERCNT 517
SCG+G C S RV V E C + +KP + C CPA W C+
Sbjct: 875 VSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW-QYKLAACSV 933
Query: 518 TCGRGVKKRLVLCMELANGKPQTRS---GPECGLAKKPPEESTCFERPC-FKWYTSPWSE 573
+CGRGV +R++ C A+G+ +C +P + C PC +W
Sbjct: 934 SCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP 992
Query: 574 CTKTCGVGVRMRDVKCY---QGTDI---VRGCDPLVKPVGRQACDLQPC 616
C+ +CG+G R V C QG D+ C LV+P C + C
Sbjct: 993 CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
Score = 90.1 bits (222), Expect = 6e-18
Identities = 68/219 (31%), Positives = 94/219 (42%), Gaps = 31/219 (14%)
Query: 260 TRPKARK---QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVD-DS 311
++P +R+ Q V +++KL++ CS +C GV+ C R DG E+ D+
Sbjct: 906 SKPGSRREVCQAVPCPARWQYKLAA---CSVSCGRGVVRRILYCARAHGEDDGEEILLDT 962
Query: 312 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
C L RPEP E C+ C PRW+ S CS +CG G R V C + L G D V
Sbjct: 963 QCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVEVD 1020
Query: 372 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRD------IRCSED 425
C A VRPE C C +W + W EC+ CG+ RD +
Sbjct: 1021 EAACAAL--VRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVP 1078
Query: 426 EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ 464
C +PV + C PC Q G+CG+
Sbjct: 1079 ADFCQHLPKPVTVRGCWAGPCVGQ----------GACGR 1107
Score = 72.0 bits (175), Expect = 2e-12
Identities = 71/316 (22%), Positives = 105/316 (33%), Gaps = 60/316 (18%)
Query: 356 VRCWKMLSPGFDSSVYSDLCEA-AEAVRPEERKTCRNPACGPQWEMSEW-SECTAKCGE- 412
+R W L D VY E RP+ T P W + C+ CG
Sbjct: 612 IRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAG 671
Query: 413 ------------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSG 460
R + ++C ++ P + C PC W V D+GPCS
Sbjct: 672 LRWVNYSCLDQARKELVETVQCQGSQQ------PPAWPEACVLEPCPPYWAVGDFGPCSA 725
Query: 461 SCGQGRTIRHVYCKTSDG---RVVPESQCQ--METKPLAIHPCGDKNCPAHWLAQDWERC 515
SCG G R V C + G + +P ++C+ + +A+ C + CPA W + C
Sbjct: 726 SCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSC 785
Query: 516 NTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-------- 567
+ G G+ C+ A+G + + +K P C C +
Sbjct: 786 TSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSA 845
Query: 568 ----TSPW-----------------SECTKTCGVGVRMRDVKCYQGTDIV----RGCDPL 602
SPW C+ +CG G+ C V C
Sbjct: 846 GEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLA 905
Query: 603 VKPVG-RQACDLQPCP 617
KP R+ C PCP
Sbjct: 906 SKPGSRREVCQAVPCP 921
Score = 29.6 bits (65), Expect = 9.3
Identities = 19/72 (26%), Positives = 28/72 (38%), Gaps = 1/72 (1%)
Query: 258 ARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDG-VEVDDSYCDAL 316
A RP+A + YRW + + CS +C G+ C+ V +C L
Sbjct: 1026 ALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL 1085
Query: 317 TRPEPVHEFCAG 328
+P V AG
Sbjct: 1086 PKPVTVRGCWAG 1097
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 124 bits (312), Expect = 2e-28
Identities = 106/422 (25%), Positives = 155/422 (36%), Gaps = 67/422 (15%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCVRYDGV---EVDDSYCDA-LTRPEPVHEFCAGRECQ 332
W + PCSA+C G+ CV G + + C A +P E C + C
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 333 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE--ERKTCR 390
RWE S S C+ G G C PG D + + + E +V + + C
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETC----VPGADG-LEAPVTEGPGSVDEKLPAPEPCV 860
Query: 391 NPACGPQW-----------EMSEWSE-----------------CTAKCGERSVVTR---- 418
+C P W S W C+ CG + R
Sbjct: 861 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 920
Query: 419 --DIRCSEDEKLCDPNTRPVGEKN-CTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT 475
+R E+LC ++P + C PC +W CS SCG+G R +YC
Sbjct: 921 DSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYK-LAACSVSCGRGVVRRILYCAR 979
Query: 476 SDGR-----VVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLC 530
+ G ++ ++QCQ +P C + CP W C+ +CG G +R V C
Sbjct: 980 AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVAC 1039
Query: 531 MELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC 589
++L G+ C +P C C ++W+ W EC+ +CG G++ R C
Sbjct: 1040 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1099
Query: 590 Y----QGTDIVRGCDPLVKPVGRQACDLQPC---------PTEPPDDSCQDQPG-TNCAL 635
Q C L KPV + C PC EP PG +CA+
Sbjct: 1100 LGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAV 1159
Query: 636 AI 637
AI
Sbjct: 1160 AI 1161
Score = 116 bits (291), Expect = 6e-26
Identities = 110/409 (26%), Positives = 152/409 (37%), Gaps = 57/409 (13%)
Query: 260 TRPKARKQGVSPADMYRWKLSS-HEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALT 317
TRP P W ++ PCS +C G+ C+ E V+ C
Sbjct: 669 TRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQ 728
Query: 318 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
+P E C C P W + CS +CG G + R VRC + ++ C A
Sbjct: 729 QPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE-AQGSLLKTLPPARCRA 787
Query: 378 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC--------------- 422
+TC C +WE+SE S CT+ G + + C
Sbjct: 788 GAQQPAVALETCNPQPCPARWEVSEPSSCTS-AGGAGLALENETCVPGADGLEAPVTEGP 846
Query: 423 -SEDEKL----------CDP-----NTRPVGEKN-------CTGPPCDRQWTVSDWGPCS 459
S DEKL C P + GEK TG WT + G CS
Sbjct: 847 GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAA-GSCS 905
Query: 460 GSCGQGRTIRHVYCKTSDGRV-VPESQCQMETKPLAIHP-CGDKNCPAHWLAQDWERCNT 517
SCG+G C S RV V E C + +KP + C CPA W C+
Sbjct: 906 VSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW-QYKLAACSV 964
Query: 518 TCGRGVKKRLVLCMELANGKPQTRS---GPECGLAKKPPEESTCFERPC-FKWYTSPWSE 573
+CGRGV +R++ C A+G+ +C +P + C PC +W
Sbjct: 965 SCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP 1023
Query: 574 CTKTCGVGVRMRDVKCY---QGTDI---VRGCDPLVKPVGRQACDLQPC 616
C+ +CG+G R V C QG D+ C LV+P C + C
Sbjct: 1024 CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Score = 90.1 bits (222), Expect = 6e-18
Identities = 68/219 (31%), Positives = 94/219 (42%), Gaps = 31/219 (14%)
Query: 260 TRPKARK---QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVD-DS 311
++P +R+ Q V +++KL++ CS +C GV+ C R DG E+ D+
Sbjct: 937 SKPGSRREVCQAVPCPARWQYKLAA---CSVSCGRGVVRRILYCARAHGEDDGEEILLDT 993
Query: 312 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
C L RPEP E C+ C PRW+ S CS +CG G R V C + L G D V
Sbjct: 994 QCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVEVD 1051
Query: 372 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRD------IRCSED 425
C A VRPE C C +W + W EC+ CG+ RD +
Sbjct: 1052 EAACAAL--VRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVP 1109
Query: 426 EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ 464
C +PV + C PC Q G+CG+
Sbjct: 1110 ADFCQHLPKPVTVRGCWAGPCVGQ----------GACGR 1138
Score = 72.0 bits (175), Expect = 2e-12
Identities = 71/316 (22%), Positives = 105/316 (33%), Gaps = 60/316 (18%)
Query: 356 VRCWKMLSPGFDSSVYSDLCEA-AEAVRPEERKTCRNPACGPQWEMSEW-SECTAKCGE- 412
+R W L D VY E RP+ T P W + C+ CG
Sbjct: 643 IRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAG 702
Query: 413 ------------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSG 460
R + ++C ++ P + C PC W V D+GPCS
Sbjct: 703 LRWVNYSCLDQARKELVETVQCQGSQQ------PPAWPEACVLEPCPPYWAVGDFGPCSA 756
Query: 461 SCGQGRTIRHVYCKTSDG---RVVPESQCQ--METKPLAIHPCGDKNCPAHWLAQDWERC 515
SCG G R V C + G + +P ++C+ + +A+ C + CPA W + C
Sbjct: 757 SCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSC 816
Query: 516 NTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-------- 567
+ G G+ C+ A+G + + +K P C C +
Sbjct: 817 TSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSA 876
Query: 568 ----TSPW-----------------SECTKTCGVGVRMRDVKCYQGTDIV----RGCDPL 602
SPW C+ +CG G+ C V C
Sbjct: 877 GEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLA 936
Query: 603 VKPVG-RQACDLQPCP 617
KP R+ C PCP
Sbjct: 937 SKPGSRREVCQAVPCP 952
Score = 29.6 bits (65), Expect = 9.3
Identities = 19/72 (26%), Positives = 28/72 (38%), Gaps = 1/72 (1%)
Query: 258 ARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDG-VEVDDSYCDAL 316
A RP+A + YRW + + CS +C G+ C+ V +C L
Sbjct: 1057 ALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL 1116
Query: 317 TRPEPVHEFCAG 328
+P V AG
Sbjct: 1117 PKPVTVRGCWAG 1128
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 124 bits (311), Expect = 3e-28
Identities = 98/391 (25%), Positives = 145/391 (37%), Gaps = 57/391 (14%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCVRYDGV---EVDDSYCDA-LTRPEPVHEFCAGRECQ 332
W + PCSA+C G+ CV G + + C A +P E C + C
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 333 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE--ERKTCR 390
RWE S S C+ G G C PG D + + + E +V + + C
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETC----VPGADG-LEAPVTEGPGSVDEKLPAPEPCV 860
Query: 391 NPACGPQW-----------EMSEWSE-----------------CTAKCGERSVVTR---- 418
+C P W S W C+ CG + R
Sbjct: 861 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 920
Query: 419 --DIRCSEDEKLCDPNTRPVGEKN-CTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT 475
+R E+LC ++P + C PC +W CS SCG+G R +YC
Sbjct: 921 DSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYK-LAACSVSCGRGVVRRILYCAR 979
Query: 476 SDGR-----VVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLC 530
+ G ++ ++QCQ +P C + CP W C+ +CG G +R V C
Sbjct: 980 AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVAC 1039
Query: 531 MELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC 589
++L G+ C +P C C ++W+ W EC+ +CG G++ R C
Sbjct: 1040 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1099
Query: 590 Y----QGTDIVRGCDPLVKPVGRQACDLQPC 616
Q C L KPV + C PC
Sbjct: 1100 LGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 116 bits (291), Expect = 6e-26
Identities = 110/409 (26%), Positives = 152/409 (37%), Gaps = 57/409 (13%)
Query: 260 TRPKARKQGVSPADMYRWKLSS-HEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALT 317
TRP P W ++ PCS +C G+ C+ E V+ C
Sbjct: 669 TRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQ 728
Query: 318 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
+P E C C P W + CS +CG G + R VRC + ++ C A
Sbjct: 729 QPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE-AQGSLLKTLPPARCRA 787
Query: 378 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC--------------- 422
+TC C +WE+SE S CT+ G + + C
Sbjct: 788 GAQQPAVALETCNPQPCPARWEVSEPSSCTS-AGGAGLALENETCVPGADGLEAPVTEGP 846
Query: 423 -SEDEKL----------CDP-----NTRPVGEKN-------CTGPPCDRQWTVSDWGPCS 459
S DEKL C P + GEK TG WT + G CS
Sbjct: 847 GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAA-GSCS 905
Query: 460 GSCGQGRTIRHVYCKTSDGRV-VPESQCQMETKPLAIHP-CGDKNCPAHWLAQDWERCNT 517
SCG+G C S RV V E C + +KP + C CPA W C+
Sbjct: 906 VSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW-QYKLAACSV 964
Query: 518 TCGRGVKKRLVLCMELANGKPQTRS---GPECGLAKKPPEESTCFERPC-FKWYTSPWSE 573
+CGRGV +R++ C A+G+ +C +P + C PC +W
Sbjct: 965 SCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP 1023
Query: 574 CTKTCGVGVRMRDVKCY---QGTDI---VRGCDPLVKPVGRQACDLQPC 616
C+ +CG+G R V C QG D+ C LV+P C + C
Sbjct: 1024 CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Score = 97.4 bits (241), Expect = 4e-20
Identities = 89/353 (25%), Positives = 136/353 (38%), Gaps = 58/353 (16%)
Query: 316 LTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 375
LTRP+ + + Q + CS +CG G ++ C L V + C
Sbjct: 668 LTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSC---LDQARKELVETVQC 724
Query: 376 EAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRP 435
+ ++ P + C C P W + ++ C+A CG + R +RC E + P
Sbjct: 725 QGSQQP-PAWPEACVLEPCPPYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPP 782
Query: 436 -----------VGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT-SDGRVVP- 482
V + C PC +W VS+ C+ + G G + + C +DG P
Sbjct: 783 ARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPV 842
Query: 483 -ESQCQMETKPLAIHPCGDKNCPAHW------------------------LAQDWE---- 513
E ++ K A PC +CP W A W
Sbjct: 843 TEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAG 902
Query: 514 RCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP-PEESTCFERPCFKWYTSPWS 572
C+ +CGRG+ + LCM+ A P CGLA KP C PC + +
Sbjct: 903 SCSVSCGRGLMELRFLCMDSALRVPVQEE--LCGLASKPGSRREVCQAVPCPARWQYKLA 960
Query: 573 ECTKTCGVGVRMRDVKCYQ------GTDIVRG--CDPLVKPVGRQACDLQPCP 617
C+ +CG GV R + C + G +I+ C L +P ++AC L+PCP
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 1013
Score = 91.7 bits (226), Expect = 2e-18
Identities = 71/222 (31%), Positives = 96/222 (43%), Gaps = 22/222 (9%)
Query: 260 TRPKARK---QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVD-DS 311
++P +R+ Q V +++KL++ CS +C GV+ C R DG E+ D+
Sbjct: 937 SKPGSRREVCQAVPCPARWQYKLAA---CSVSCGRGVVRRILYCARAHGEDDGEEILLDT 993
Query: 312 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
C L RPEP E C+ C PRW+ S CS +CG G R V C + L G D V
Sbjct: 994 QCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVEVD 1051
Query: 372 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRD------IRCSED 425
C A VRPE C C +W + W EC+ CG+ RD +
Sbjct: 1052 EAACAAL--VRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVP 1109
Query: 426 EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRT 467
C +PV + C PC Q T S P + GRT
Sbjct: 1110 ADFCQHLPKPVTVRGCWAGPCVGQGTPS-LVPHEEAAAPGRT 1150
Score = 72.0 bits (175), Expect = 2e-12
Identities = 71/316 (22%), Positives = 105/316 (33%), Gaps = 60/316 (18%)
Query: 356 VRCWKMLSPGFDSSVYSDLCEA-AEAVRPEERKTCRNPACGPQWEMSEW-SECTAKCGE- 412
+R W L D VY E RP+ T P W + C+ CG
Sbjct: 643 IRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAG 702
Query: 413 ------------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSG 460
R + ++C ++ P + C PC W V D+GPCS
Sbjct: 703 LRWVNYSCLDQARKELVETVQCQGSQQ------PPAWPEACVLEPCPPYWAVGDFGPCSA 756
Query: 461 SCGQGRTIRHVYCKTSDG---RVVPESQCQ--METKPLAIHPCGDKNCPAHWLAQDWERC 515
SCG G R V C + G + +P ++C+ + +A+ C + CPA W + C
Sbjct: 757 SCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSC 816
Query: 516 NTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-------- 567
+ G G+ C+ A+G + + +K P C C +
Sbjct: 817 TSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSA 876
Query: 568 ----TSPW-----------------SECTKTCGVGVRMRDVKCYQGTDIV----RGCDPL 602
SPW C+ +CG G+ C V C
Sbjct: 877 GEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLA 936
Query: 603 VKPVG-RQACDLQPCP 617
KP R+ C PCP
Sbjct: 937 SKPGSRREVCQAVPCP 952
Score = 29.6 bits (65), Expect = 9.3
Identities = 19/72 (26%), Positives = 28/72 (38%), Gaps = 1/72 (1%)
Query: 258 ARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDG-VEVDDSYCDAL 316
A RP+A + YRW + + CS +C G+ C+ V +C L
Sbjct: 1057 ALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL 1116
Query: 317 TRPEPVHEFCAG 328
+P V AG
Sbjct: 1117 PKPVTVRGCWAG 1128
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 120 bits (302), Expect = 3e-27
Identities = 81/274 (29%), Positives = 115/274 (41%), Gaps = 35/274 (12%)
Query: 210 ENEGAGPYLLNGSYLELSS---------------DRVANSSSEAPFPNVSTSLLTSAGNR 254
+N+ G Y+LNG E S D + + ++ P + L+ N
Sbjct: 756 KNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQEND 815
Query: 255 THKARTRPKARKQGVSPA-----------DMYRWKLSSHEPCSATCTTGVMSAYAMCVRY 303
T + T + P D + W L S CS C G C R
Sbjct: 816 TRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRK 875
Query: 304 -DGVEVDDSYCDALTRPEPVHEFCAGREC-QPRWETSSWSECSRTCG-EGYQFRVVRCWK 360
D V S+C+A +P+P+ C +EC P W W C++TCG GYQ R VRC +
Sbjct: 876 SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQ 935
Query: 361 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDI 420
L G + SV+S C RPE R+ C C QW+ WSEC+ CGE + V R +
Sbjct: 936 PLLDGTNRSVHSKYCMGD---RPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEV-RQV 991
Query: 421 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSD 454
C + CD +P + C PPC+ + + D
Sbjct: 992 LCRAGDH-CD-GEKPESVRACQLPPCNDEPCLGD 1023
Score = 119 bits (298), Expect = 9e-27
Identities = 72/213 (33%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 449 QWTVSDWGPCSGSCGQGRTIRHVYCKT-SDGRVVPESQCQMETKPLAIHP-CGDKNCPAH 506
+W + W CS CG G C+ SD ++V S C+ KP I C + C
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 507 -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 563
W+A++WE C TCG G + R V C++ L +G ++ C + +P C PC
Sbjct: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966
Query: 564 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622
+W T PWSEC+ TCG G +R V C G CD KP +AC L PC EP
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH----CDG-EKPESVRACQLPPCNDEP-- 1019
Query: 623 DSCQDQPGTNCALAIKVNLCGHWYYSKACCRSC 655
C C + + C Y+K CC SC
Sbjct: 1020 --CLGDKSIFCQMEVLARYCSIPGYNKLCCESC 1050
Score = 101 bits (252), Expect = 2e-21
Identities = 58/182 (31%), Positives = 75/182 (41%), Gaps = 19/182 (10%)
Query: 335 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 394
W SWS+CS+ CG G+Q+ C + + V+ CEA + +P R
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSD---NKMVHRSFCEANKKPKPIRRMCNIQECT 905
Query: 395 GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGP---------- 444
P W EW CT CG R +RC + L D R V K C G
Sbjct: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQP--LLDGTNRSVHSKYCMGDRPESRRPCNR 963
Query: 445 -PCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD--GRVVPESQCQMETKPLAIHPC-GD 500
PC QW W CS +CG+G +R V C+ D PES + P PC GD
Sbjct: 964 VPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGD 1023
Query: 501 KN 502
K+
Sbjct: 1024 KS 1025
Score = 80.5 bits (197), Expect = 5e-15
Identities = 55/180 (30%), Positives = 74/180 (41%), Gaps = 25/180 (13%)
Query: 397 QWEMSEWSECTAKCGERSVVTR-DIRCSEDEKL-----CDPNTRPVG-EKNCTGPPCDRQ 449
+W + WS+C+ CG T+ R D K+ C+ N +P + C C
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 450 -WTVSDWGPCSGSCGQ-GRTIRHVYCKTS--DG--RVVPESQCQMETKPLAIHPCGDKNC 503
W +W C+ +CG G +R V C DG R V C M +P + PC C
Sbjct: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966
Query: 504 PAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC 563
PA W W C+ TCG G + R VLC R+G C +KP C PC
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLC----------RAGDHCD-GEKPESVRACQLPPC 1015
Score = 35.8 bits (81), Expect = 0.13
Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Query: 560 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQ 614
E F+W WS+C+K CG G + C + +D + R C+ KP R+ C++Q
Sbjct: 843 ELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQ 902
Query: 615 PC 616
C
Sbjct: 903 EC 904
Score = 31.2 bits (69), Expect = 3.2
Identities = 29/119 (24%), Positives = 41/119 (34%), Gaps = 20/119 (16%)
Query: 546 CGLAKKPPEEST-------CFERPCF-----------KWYT-SPWSECTKTCGVGVRMRD 586
C K PP + T C++ C W + + + C++TCG GVR R
Sbjct: 516 CKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRT 575
Query: 587 VKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 645
+C I G D Q C+ + C D Q N + N HW
Sbjct: 576 RQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQ-NTKHHW 633
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 119 bits (298), Expect = 9e-27
Identities = 75/240 (31%), Positives = 104/240 (43%), Gaps = 32/240 (13%)
Query: 335 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 394
W +WSECS TCG G +R V C S DS C A + RP+ K C C
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVEC----STQMDSD-----CAAIQ--RPDPAKRCHLRPC 1365
Query: 395 GPQWEMSEWSECTAKCGERSVVTRDIRC--SEDEKLCDP-------NTRPVGEKNCTGPP 445
W++ WS+C+ C + R+I+C S D + P P +C P
Sbjct: 1366 AG-WKVGNWSKCSRNCSGGFKI-REIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEP 1423
Query: 446 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPA 505
C+ W V W CS SCG G R V+C P C +P + C + C
Sbjct: 1424 CEA-WQVEPWSQCSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLC-C 1473
Query: 506 HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK 565
HW +W+ C+T+CG G +KR V C+ K + + C +PPE C ++ C K
Sbjct: 1474 HWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK 1533
Score = 110 bits (274), Expect = 5e-24
Identities = 78/274 (28%), Positives = 109/274 (39%), Gaps = 27/274 (9%)
Query: 398 WEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWG 456
W + WSEC+ CG R + CS + C RP K C PC W V +W
Sbjct: 1317 WIVGNWSECSTTCG-LGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPC-AGWKVGNWS 1374
Query: 457 PCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMET---KPLAIHPCGDKNCPAHWLAQDW 512
CS +C G IR + C S D R + CQ PL++ C + C A W + W
Sbjct: 1375 KCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMS-CNPEPCEA-WQVEPW 1432
Query: 513 ERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWS 572
+C+ +CG GV++R V C G C K+P +C E C W T W
Sbjct: 1433 SQCSRSCGGGVQERGVFC-----------PGGLCDWTKRPTSTMSCNEHLCCHWATGNWD 1481
Query: 573 ECTKTCGVGVRMRDVKCYQGTDIVRG------CDPLVKPVGRQACDLQPCPTEPPDDSCQ 626
C+ +CG G + R V+C CD +P + C+ Q C +
Sbjct: 1482 LCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTK 1541
Query: 627 DQPGTNCALAIK-VNLCGHWYYSKACCRSCRPPH 659
D+ + +K + C CC SC H
Sbjct: 1542 DKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTH 1575
Score = 107 bits (268), Expect = 3e-23
Identities = 62/174 (35%), Positives = 80/174 (45%), Gaps = 8/174 (4%)
Query: 450 WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHP-CGDKNCPAHWL 508
W W CS +CG G + +C +V + C ET+P C +K CP W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 509 AQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF--- 564
A +WE C+ TCG G KKR VLC++ Q +C KP +C R
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSC-NRDILCPS 946
Query: 565 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPT 618
W WSEC+ +CG GVR+R V C + D CD KP R C LQ CP+
Sbjct: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNHD--EPCDVTRKPNSRALCGLQQCPS 998
Score = 91.7 bits (226), Expect = 2e-18
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 14/230 (6%)
Query: 274 MYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP 333
MY W+ CS TC TG+ A C++ V ++CD T+P + C + C P
Sbjct: 825 MYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Query: 334 RWETSSWSECSRTCG-EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC-RN 391
RW W CS TCG G + R V C + + + +D C+ ++P+ +C R+
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD-CQ--HLLKPKTLLSCNRD 941
Query: 392 PACGPQWEMSEWSECTAKCGERSVVTRDIRCSED-EKLCDPNTRPVGEKNCTGPPCDRQW 450
C W + WSEC+ CG V R + C+++ ++ CD +P C C
Sbjct: 942 ILCPSDWTVGNWSECSVSCG-GGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSR 1000
Query: 451 TVSDWGPCSGSCGQGR---TIRHVYCKTSDGRVV--PESQCQMETKPLAI 495
V P G+ G+ T++ V TS R++ P M T AI
Sbjct: 1001 RVLK--PNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAI 1048
Score = 90.5 bits (223), Expect = 4e-18
Identities = 51/178 (28%), Positives = 74/178 (41%), Gaps = 11/178 (6%)
Query: 439 KNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC 498
K T W V +W CS +CG G R V C T +S C +P C
Sbjct: 1306 KQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ-----MDSDCAAIQRPDPAKRC 1360
Query: 499 GDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC 558
+ C A W +W +C+ C G K R + C++ + + + PP +C
Sbjct: 1361 HLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSC 1419
Query: 559 FERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC 616
PC W PWS+C+++CG GV+ R V C G CD +P +C+ C
Sbjct: 1420 NPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL-----CDWTKRPTSTMSCNEHLC 1472
Score = 75.5 bits (184), Expect = 1e-13
Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 22/137 (16%)
Query: 505 AHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCF 564
AHW+ +W C+TTCG G R V C T+ +C ++P C RPC
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDCAAIQRPDPAKRCHLRPCA 1366
Query: 565 KWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPL-------VKPVGRQACDLQPCP 617
W WS+C++ C G ++R+++C D R P + P +C+ +PC
Sbjct: 1367 GWKVGNWSKCSRNCSGGFKIREIQCVDSRD-HRNLRPFHCQFLAGIPPPLSMSCNPEPC- 1424
Query: 618 TEPPDDSCQDQPGTNCA 634
++ Q +P + C+
Sbjct: 1425 -----EAWQVEPWSQCS 1436
Score = 72.0 bits (175), Expect = 2e-12
Identities = 52/183 (28%), Positives = 71/183 (38%), Gaps = 28/183 (15%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTR-PEPVHEFCAGRECQPR 334
WK+ + CS C+ G CV D + +C L P P+ C C+
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA- 1426
Query: 335 WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPAC 394
W+ WS+CSR+CG G Q R V C PG LC+ + RP +C C
Sbjct: 1427 WQVEPWSQCSRSCGGGVQERGVFC-----PG-------GLCDWTK--RPTSTMSCNEHLC 1472
Query: 395 GPQWEMSEWSECTAKCGERSVVTRDIRC---------SEDEKLCDPNTRPVGEKNCTGPP 445
W W C+ CG R ++C +D+ LCD RP K C
Sbjct: 1473 -CHWATGNWDLCSTSCG-GGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA 1530
Query: 446 CDR 448
C +
Sbjct: 1531 CKK 1533
Score = 53.9 bits (128), Expect = 5e-07
Identities = 39/133 (29%), Positives = 50/133 (37%), Gaps = 13/133 (9%)
Query: 262 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 321
P +P W++ CS +C GV GV CD RP
Sbjct: 1412 PPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQER--------GVFCPGGLCDWTKRPTS 1463
Query: 322 VHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAV 381
C C W T +W CS +CG G+Q R V+C + S G + + D C
Sbjct: 1464 TMS-CNEHLC-CHWATGNWDLCSTSCGGGFQKRTVQC--VPSEG-NKTEDQDQCLCDHKP 1518
Query: 382 RPEERKTCRNPAC 394
RP E K C AC
Sbjct: 1519 RPPEFKKCNQQAC 1531
Score = 47.0 bits (110), Expect = 6e-05
Identities = 23/62 (37%), Positives = 34/62 (54%), Gaps = 4/62 (6%)
Query: 560 ERPCFKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRG--CDPLVKPVGRQ-ACDLQP 615
E+ + W W+EC+ TCG G+R + C +G +V+ CDP +P GRQ C +
Sbjct: 822 EQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKA 881
Query: 616 CP 617
CP
Sbjct: 882 CP 883
Score = 37.0 bits (84), Expect = 0.058
Identities = 17/53 (32%), Positives = 26/53 (49%)
Query: 569 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPP 621
SPWS C++TCG GV+ + C G + + C++ PC +E P
Sbjct: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAP 601
Score = 32.3 bits (72), Expect = 1.4
Identities = 35/140 (25%), Positives = 49/140 (35%), Gaps = 28/140 (20%)
Query: 372 SDLCEAAEAVRPEERKTCRNPAC-----------GPQWEMSEWSECTAKCGERSVVTRDI 420
S L AA+ + E+K C C G S WS C+ CG
Sbjct: 509 SKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCG--------A 560
Query: 421 RCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 480
E+LC+ G K CTG +++ + + PC + T R + C D
Sbjct: 561 GVQSAERLCNNPEPKFGGKYCTGE--RKRYRLCNVHPCR---SEAPTFRQMQCSEFD--T 613
Query: 481 VPESQCQMETKPL--AIHPC 498
VP P+ HPC
Sbjct: 614 VPYKNELYHWFPIFNPAHPC 633
Score = 32.0 bits (71), Expect = 1.9
Identities = 25/101 (24%), Positives = 37/101 (36%), Gaps = 6/101 (5%)
Query: 271 PADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRE 330
P RW SH CS TC GV SA +C + + YC T + C
Sbjct: 542 PGGWGRWSPWSH--CSRTCGAGVQSAERLCNNPE-PKFGGKYC---TGERKRYRLCNVHP 595
Query: 331 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
C+ T +CS Y+ + + + +P +Y
Sbjct: 596 CRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELY 636
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 115 bits (287), Expect = 2e-25
Identities = 69/189 (36%), Positives = 91/189 (48%), Gaps = 16/189 (8%)
Query: 277 WKLSSHEPCSATCTTGVMSAYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 335
WK H CSA+C GV +C+ R G E+D+ C A RP E C G C P W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 336 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 395
E W+ CSR+CG G Q R ++C + G SSV + C RP ++C+ CG
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGG-GSSVPPERC--GHLPRPNITQSCQLRLCG 784
Query: 396 PQWEM-SEWSECTAKCGERSVVTRDIRC--------SEDEKLCDPNTRPVGEKNCTGPPC 446
WE+ S WS+C+ +CG R +R +RC SE E P +P + C PC
Sbjct: 785 -HWEVGSPWSQCSVRCG-RGQRSRQVRCVGNNGDEVSEQECASGP-PQPPSREACDMGPC 841
Query: 447 DRQWTVSDW 455
W SDW
Sbjct: 842 TTAWFHSDW 850
Score = 94.4 bits (233), Expect = 3e-19
Identities = 60/196 (30%), Positives = 83/196 (42%), Gaps = 20/196 (10%)
Query: 450 WTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAI-HPCGDKNCPAHW 507
W CS SCG+G C + + G + E C +P A PC CP +W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 508 LAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY 567
A +W C+ +CG G + R + C + G + CG +P +C R C W
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 568 T-SPWSECTKTCGVGVRMRDVKCY--QGTDIVRG--CDPLVKPVGRQACDLQPCPT---- 618
SPWS+C+ CG G R R V+C G ++ +P R+ACD+ PC T
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFH 847
Query: 619 ---------EPPDDSC 625
EPP SC
Sbjct: 848 SDWSSKVSPEPPAISC 863
Score = 91.3 bits (225), Expect = 3e-18
Identities = 63/206 (30%), Positives = 88/206 (42%), Gaps = 25/206 (12%)
Query: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGE---RSV---VTRDIRCSEDEKLCDPNTRP- 435
P R +PA W+ S C+A CG+ R + ++R+ DE+ C RP
Sbjct: 655 PHPRTPLGSPAA--YWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPP 712
Query: 436 VGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT---SDGRVVPESQCQMETKP 492
+ C G PC W +W CS SCG G R + C+ G VP +C +P
Sbjct: 713 ASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRP 772
Query: 493 LAIHPCGDKNCPAHW-LAQDWERCNTTCGRGVKKRLVLCMELANG----KPQTRSGPECG 547
C + C HW + W +C+ CGRG + R V C+ NG + + SGP
Sbjct: 773 NITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECASGP--- 827
Query: 548 LAKKPPEESTCFERPC-FKWYTSPWS 572
+PP C PC W+ S WS
Sbjct: 828 --PQPPSREACDMGPCTTAWFHSDWS 851
Score = 65.1 bits (157), Expect = 2e-10
Identities = 39/165 (23%), Positives = 65/165 (39%), Gaps = 23/165 (13%)
Query: 483 ESQCQMETKPLAIHPCGDKNCPA-HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTR 541
+ Q ++ P HP PA +W C+ +CG+GV + + LC+ +G+
Sbjct: 643 QRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDE 702
Query: 542 SGPECGLAKKPPEESTCFERPCFK-WYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCD 600
G A+ P C PC W W+ C+++CG G + R ++C Q
Sbjct: 703 RSCAAG-ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQ--------- 752
Query: 601 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALAIKVNLCGHW 645
+ + P + C P N + ++ LCGHW
Sbjct: 753 -----------EFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHW 786
Score = 37.4 bits (85), Expect = 0.044
Identities = 21/66 (31%), Positives = 26/66 (39%), Gaps = 1/66 (1%)
Query: 277 WKLSSH-EPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 335
W++ S CS C G S CV +G EV + C + P E C C W
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
Query: 336 ETSSWS 341
S WS
Sbjct: 846 FHSDWS 851
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 108 bits (271), Expect = 1e-23
Identities = 91/291 (31%), Positives = 125/291 (42%), Gaps = 34/291 (11%)
Query: 273 DMYRWKLSSHEPCSATCTTGV-MSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 331
D Y W L S PCS C G+ + Y R D V CD RP+P+ C C
Sbjct: 847 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 906
Query: 332 -QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 389
QP W T W CSR+CG+ G Q R ++C LS G + + C RPE R+ C
Sbjct: 907 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEARRPC 963
Query: 390 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQ 449
C QW + WS+C+A CGE + + +C N +G +C G DR
Sbjct: 964 LRVPCPAQWRLGAWSQCSATCGE--------GIQQRQVVCRTNANSLG--HCEG---DRP 1010
Query: 450 WTVSDWG-PCSGSCGQGRTIRHVYCK--TSDGRVVPESQ-CQMETKPLAIHPC-GDKNCP 504
TV P G Q T+R + T +G+ VP+S+ K + PC GD++
Sbjct: 1011 DTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRS-- 1068
Query: 505 AHWLAQDWERCNTTCGRGVKKRL--VLCMELANGKPQTRSGPECGLAKKPP 553
+ E + C RL V C++ A+G GP+ G PP
Sbjct: 1069 ---VFCQMEVLDRYCSIPGYHRLCCVSCIKKASG---PNPGPDPGPTSLPP 1113
Score = 90.1 bits (222), Expect = 6e-18
Identities = 62/250 (24%), Positives = 95/250 (38%), Gaps = 49/250 (19%)
Query: 449 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAI------HPCGDK 501
+W + W PCS +CG G C+ D +V C + +P I HPC
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 502 NCPAHWLAQDWERCNTTCGR-GVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCF 559
W+ ++W C+ +CG+ GV+ R + C+ L+NG + C +P C
Sbjct: 910 V----WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA-GDRPEARRPCL 964
Query: 560 ERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC-- 616
PC +W WS+C+ TCG G++ R V C + + C+ +P Q C L C
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1023
Query: 617 --------------------------PTEPPDDSCQDQPGTN-----CALAIKVNLCGHW 645
P P + +P T C + + C
Sbjct: 1024 NHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIP 1083
Query: 646 YYSKACCRSC 655
Y + CC SC
Sbjct: 1084 GYHRLCCVSC 1093
Score = 56.6 bits (135), Expect = 7e-08
Identities = 43/144 (29%), Positives = 58/144 (40%), Gaps = 15/144 (10%)
Query: 256 HKARTRPKARKQGVSPADMYRWKLSSHEPCSATC-TTGVMSAYAMCVR--YDGV-EVDDS 311
HK R +P R+ P W CS +C GV + C+ +G +V +
Sbjct: 890 HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPA 949
Query: 312 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
A RPE C C +W +WS+CS TCGEG Q R V C
Sbjct: 950 KACAGDRPE-ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC----------RTN 998
Query: 372 SDLCEAAEAVRPEERKTCRNPACG 395
++ E RP+ + C PACG
Sbjct: 999 ANSLGHCEGDRPDTVQVCSLPACG 1022
Score = 34.7 bits (78), Expect = 0.29
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 16/95 (16%)
Query: 538 PQTRSGPECGLAKKPPEESTCF-----------ERPCFKWYTSPWSECTKTCGVGVRMRD 586
P T GP LA K E ++W W+ C+K CG G++
Sbjct: 812 PPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 871
Query: 587 VKCYQGTD--IVRG--CDPLVKPVG-RQACDLQPC 616
C + D +V+ CD +P R+ C+ PC
Sbjct: 872 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 906
Score = 30.8 bits (68), Expect = 4.2
Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 22/93 (23%)
Query: 546 CGLAKKPPEEST-------CFERPCFKWYT-----------SPWSE---CTKTCGVGVRM 584
C K PP + T CF+ C W + S W++ C+++CG GVR
Sbjct: 516 CKTKKGPPLDGTECAPGKWCFKGHCI-WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 574
Query: 585 RDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 617
R C + G L Q C+ + CP
Sbjct: 575 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 108 bits (271), Expect = 1e-23
Identities = 91/291 (31%), Positives = 125/291 (42%), Gaps = 34/291 (11%)
Query: 273 DMYRWKLSSHEPCSATCTTGV-MSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 331
D Y W L S PCS C G+ + Y R D V CD RP+P+ C C
Sbjct: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
Query: 332 -QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTC 389
QP W T W CSR+CG+ G Q R ++C LS G + + C RPE R+ C
Sbjct: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGD---RPEARRPC 966
Query: 390 RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQ 449
C QW + WS+C+A CGE + + +C N +G +C G DR
Sbjct: 967 LRVPCPAQWRLGAWSQCSATCGE--------GIQQRQVVCRTNANSLG--HCEG---DRP 1013
Query: 450 WTVSDWG-PCSGSCGQGRTIRHVYCK--TSDGRVVPESQ-CQMETKPLAIHPC-GDKNCP 504
TV P G Q T+R + T +G+ VP+S+ K + PC GD++
Sbjct: 1014 DTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRS-- 1071
Query: 505 AHWLAQDWERCNTTCGRGVKKRL--VLCMELANGKPQTRSGPECGLAKKPP 553
+ E + C RL V C++ A+G GP+ G PP
Sbjct: 1072 ---VFCQMEVLDRYCSIPGYHRLCCVSCIKKASG---PNPGPDPGPTSLPP 1116
Score = 90.1 bits (222), Expect = 6e-18
Identities = 62/250 (24%), Positives = 95/250 (38%), Gaps = 49/250 (19%)
Query: 449 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAI------HPCGDK 501
+W + W PCS +CG G C+ D +V C + +P I HPC
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 502 NCPAHWLAQDWERCNTTCGR-GVKKRLVLCM-ELANGKPQTRSGPECGLAKKPPEESTCF 559
W+ ++W C+ +CG+ GV+ R + C+ L+NG + C +P C
Sbjct: 913 V----WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA-GDRPEARRPCL 967
Query: 560 ERPC-FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPC-- 616
PC +W WS+C+ TCG G++ R V C + + C+ +P Q C L C
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG-DRPDTVQVCSLPACGG 1026
Query: 617 --------------------------PTEPPDDSCQDQPGTN-----CALAIKVNLCGHW 645
P P + +P T C + + C
Sbjct: 1027 NHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIP 1086
Query: 646 YYSKACCRSC 655
Y + CC SC
Sbjct: 1087 GYHRLCCVSC 1096
Score = 56.6 bits (135), Expect = 7e-08
Identities = 43/144 (29%), Positives = 58/144 (40%), Gaps = 15/144 (10%)
Query: 256 HKARTRPKARKQGVSPADMYRWKLSSHEPCSATC-TTGVMSAYAMCVR--YDGV-EVDDS 311
HK R +P R+ P W CS +C GV + C+ +G +V +
Sbjct: 893 HKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPA 952
Query: 312 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
A RPE C C +W +WS+CS TCGEG Q R V C
Sbjct: 953 KACAGDRPE-ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVC----------RTN 1001
Query: 372 SDLCEAAEAVRPEERKTCRNPACG 395
++ E RP+ + C PACG
Sbjct: 1002 ANSLGHCEGDRPDTVQVCSLPACG 1025
Score = 34.7 bits (78), Expect = 0.29
Identities = 25/95 (26%), Positives = 37/95 (38%), Gaps = 16/95 (16%)
Query: 538 PQTRSGPECGLAKKPPEESTCF-----------ERPCFKWYTSPWSECTKTCGVGVRMRD 586
P T GP LA K E ++W W+ C+K CG G++
Sbjct: 815 PPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTK 874
Query: 587 VKCYQGTD--IVRG--CDPLVKPVG-RQACDLQPC 616
C + D +V+ CD +P R+ C+ PC
Sbjct: 875 YGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC 909
Score = 30.8 bits (68), Expect = 4.2
Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 22/93 (23%)
Query: 546 CGLAKKPPEEST-------CFERPCFKWYT-----------SPWSE---CTKTCGVGVRM 584
C K PP + T CF+ C W + S W++ C+++CG GVR
Sbjct: 519 CKTKKGPPLDGTECAPGKWCFKGHCI-WKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 577
Query: 585 RDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 617
R C + G L Q C+ + CP
Sbjct: 578 RSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 105 bits (261), Expect = 2e-22
Identities = 63/182 (34%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Query: 274 MYRWKLSSHEPCSATCTTGVM-SAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 331
+Y W L PCS C G + Y R D V +C AL++P+ + C +EC
Sbjct: 855 VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
Query: 332 QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 390
QP W T W CS+TCG G Q R VRC + L SV++ C A RPE R+ C
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA---RPESRRACS 971
Query: 391 NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPC 446
C +W WS+C+ CG ER V+ R ++D RP + C PC
Sbjct: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVL---CRTADDSFGICQEERPETARTCRLGPC 1028
Query: 447 DR 448
R
Sbjct: 1029 PR 1030
Score = 103 bits (257), Expect = 5e-22
Identities = 69/239 (28%), Positives = 98/239 (41%), Gaps = 34/239 (14%)
Query: 449 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIH-PCGDKNCPAH 506
+W + W PCS CG G C+ D ++V C +KP AI C + C
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
Query: 507 -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 563
W+ +WE C+ TCGR G++ R V C++ L + ++ C A+ P C C
Sbjct: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDAR-PESRRACSRELC 975
Query: 564 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP----- 617
+W PWS+C+ TCG G + R V C D C +P + C L PCP
Sbjct: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQE-ERPETARTCRLGPCPRNISD 1034
Query: 618 -----------TEPPDDS----------CQDQPGTNCALAIKVNLCGHWYYSKACCRSC 655
+ P DS CQ C + + C Y+K CC+SC
Sbjct: 1035 PSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
Score = 91.3 bits (225), Expect = 3e-18
Identities = 65/226 (28%), Positives = 88/226 (38%), Gaps = 34/226 (15%)
Query: 291 TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEG 350
T V Y + D + VDD+ + L V+E W WS CS+ CG G
Sbjct: 826 TRVSLTYKYMIHEDSLNVDDN--NVLEEDSVVYE----------WALKKWSPCSKPCGGG 873
Query: 351 YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE-RKTCRNPACG-PQWEMSEWSECTA 408
QF C + L V+ C A +P+ R+ C C P W EW C+
Sbjct: 874 SQFTKYGCRRRLD---HKMVHRGFCAALS--KPKAIRRACNPQECSQPVWVTGEWEPCSQ 928
Query: 409 KCGERSVVTRDIRC----------SEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC 458
CG + R +RC S K C+ + RP + C+ C +W W C
Sbjct: 929 TCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELCPGRWRAGPWSQC 987
Query: 459 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 504
S +CG G R V C+T+D CQ E +P C CP
Sbjct: 988 SVTCGNGTQERPVLCRTADDSF---GICQ-EERPETARTCRLGPCP 1029
Score = 36.6 bits (83), Expect = 0.076
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 5/58 (8%)
Query: 564 FKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQPC 616
++W WS C+K CG G + C + D + RG C L KP R+AC+ Q C
Sbjct: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
Score = 35.4 bits (80), Expect = 0.17
Identities = 29/99 (29%), Positives = 37/99 (37%), Gaps = 25/99 (25%)
Query: 546 CGLAKKPPEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMR 585
C K PP + T CF+ C W T SP+ C++TCG GV+ R
Sbjct: 526 CKTKKGPPLDGTMCAPGKHCFKGHCI-WLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFR 584
Query: 586 DVKC--YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622
+C + R C L Q C Q CP D
Sbjct: 585 TRQCDNPHPANGGRTCSGLAYDF--QLCSRQDCPDSLAD 621
Score = 29.6 bits (65), Expect = 9.3
Identities = 11/21 (52%), Positives = 14/21 (66%)
Query: 338 SSWSECSRTCGEGYQFRVVRC 358
S + CSRTCG G +FR +C
Sbjct: 568 SPFGSCSRTCGTGVKFRTRQC 588
>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
Length = 1577
Score = 102 bits (254), Expect = 1e-21
Identities = 110/386 (28%), Positives = 158/386 (40%), Gaps = 70/386 (18%)
Query: 280 SSHEPCSATCTTGVM--SAYAMCVRYDGVEVDDSYCDALTRPEPVHEF--CAGRECQPRW 335
SS CS++C GV S + Y+G L VHE C Q W
Sbjct: 976 SSWGSCSSSCGIGVRIRSKWLKEKPYNGGRPCPKL--DLKNQAQVHEAVPCYSECNQYSW 1033
Query: 336 ETSSWSEC-------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKT 388
WS C S CG G Q R +RC + G +V S+LC E P E ++
Sbjct: 1034 VVEHWSSCKINNELRSLRCGGGTQSRKIRCVNT-ADGEGGAVDSNLCNQDEI--PPETQS 1090
Query: 389 CRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLC--DPNTRP-VGEK 439
C + C + MSEW S+C C ++ R +R S + + C D +P + +
Sbjct: 1091 C-SLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLRPSLNSRTCAEDSQVQPCLLNE 1149
Query: 440 NCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQMET--KPL 493
NC Q+ +++W C S CGQG R + C SDG+ V QC+ KP
Sbjct: 1150 NCF----QFQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQ 1205
Query: 494 AIH-PCGDK---NCP-AHWLAQDWERCNTTCGRG---VKKRLVLCMELANGKPQTRSGPE 545
+ PC + NC + W A W C+ TCG G + R ++ G+P
Sbjct: 1206 RMSIPCLVECVVNCQLSGWTA--WTECSQTCGHGGRMSRTRFIIMPTQGEGRP------- 1256
Query: 546 CGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC--YQGT------- 593
+ +E TC PC+ W WS C CG GV++R + C + G+
Sbjct: 1257 --CPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGR 1314
Query: 594 --DIVRGCDPLVKPVGRQACDLQPCP 617
D + G P + +Q C + PCP
Sbjct: 1315 VEDALCGEMPFQDSILKQLCSV-PCP 1339
Score = 85.5 bits (210), Expect = 1e-16
Identities = 106/429 (24%), Positives = 151/429 (35%), Gaps = 107/429 (24%)
Query: 269 VSPADMYRWKLSSHEPCSATCTTGVM----SAYAMCVRYDGVEVDDSYCDALTRPEPVHE 324
+ P D + SS PCS TC +G + + + V++ + + L + + E
Sbjct: 301 IMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVE 360
Query: 325 FCAGRECQPR--WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGF 366
++C PR W TS W EC CG G Q R V C
Sbjct: 361 GELLQQC-PRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYC-------A 412
Query: 367 DSSVYSDLCEAAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTA 408
S + A E RP E+ C PA C +S WS C
Sbjct: 413 QSVPAAAALRAKEVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHD 472
Query: 409 KCGERSVVTRDIRCSEDEKLCDPNTRPVG-------EKNCTGPPCDRQWTVSD--WGPCS 459
G++ TR + +T P G C P C R W S+ P
Sbjct: 473 PQGKKGFRTR------QRHVLMESTGPAGHCPHLVESVPCEDPMCYR-WLASEGICFPDH 525
Query: 460 GSCGQGRTIRHVYCKTSDGRVVPESQCQM----ETKPLAIHPCGDKNCPAHWLAQDWERC 515
G CG G I C+ G V S C + E K I PC + W +W C
Sbjct: 526 GKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEI-PCRMDCVLSEW--TEWSSC 582
Query: 516 NTTC------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFK--WY 567
+ +C G+ + R +L + GKP C ++ E C + C + W
Sbjct: 583 SQSCSNKNSDGKQTRSRTILALAGEGGKP-------CPPSQALQEHRLCNDHSCMQLHWE 635
Query: 568 TSPWSECTK-----------------TCGVGVRMRDVKC---YQGTDIVRGCDPLVKPVG 607
TSPW C++ TCGVG++ R V C + G + + C +P
Sbjct: 636 TSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRPET 695
Query: 608 RQACDLQPC 616
+ C L PC
Sbjct: 696 VRPCFL-PC 703
Score = 81.3 bits (199), Expect = 3e-15
Identities = 85/366 (23%), Positives = 124/366 (33%), Gaps = 64/366 (17%)
Query: 267 QGVSPADMYRWKLSSHEPC--------------SATCTTGVMSAYAMCVRYDGVEVDDSY 312
+ VS +YRWK PC S C G+ + C+ D +
Sbjct: 759 EDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMME 818
Query: 313 CDALTRPEPVHEFCAGRECQPRWETSSWSE---CSRTCGEGYQFRVVRCWKMLSPGFDSS 369
C T P+ C+ ++WS+ CS C R K S
Sbjct: 819 CLKQTNGMPLLVQECTVPCREDCTFTAWSKFTPCSTNCEATKSRRRQLTGK--------S 870
Query: 370 VYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLC 429
+ C+ ++ E + C Q WS+C G R R +R D K C
Sbjct: 871 RKKEKCQDSDLYPLVETELCPCDEFISQ-PYGNWSDCILPEGRREP-HRGLRVQADSKEC 928
Query: 430 ------------DPNTRPVGEKNCTGP---------PCDRQWTVSDW---GPCSGSCGQG 465
D N RPV C+ PC +SDW G CS SCG G
Sbjct: 929 GEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSSCGIG 988
Query: 466 RTIRHVYCKT---SDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT---- 518
IR + K + GR P+ + + + PC + W+ + W C
Sbjct: 989 VRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINNELR 1048
Query: 519 ---CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTC---FERPCFKWYTSPWS 572
CG G + R + C+ A+G+ C + PPE +C C WS
Sbjct: 1049 SLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWS 1108
Query: 573 ECTKTC 578
+C ++C
Sbjct: 1109 KCPQSC 1114
Score = 76.3 bits (186), Expect = 9e-14
Identities = 93/379 (24%), Positives = 132/379 (34%), Gaps = 94/379 (24%)
Query: 284 PCSATCTTGVMSAYAMCV---------------RYDGVEVDDS----YCDALTRPEPVHE 324
PCS C SA+ +C+ R V ++ + +C L P
Sbjct: 449 PCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVP--- 505
Query: 325 FCAGRECQPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRP 383
C C RW S C G+ G R+++ G D S LC P
Sbjct: 506 -CEDPMCY-RWLASE-GICFPDHGKCGLGHRILKAVCQNDRGEDVS--GSLCPVPP---P 557
Query: 384 EERKTCRNPACGPQWEMSEWSE---CTAKCGERSVVTRDIR-------CSEDEKLCDPNT 433
ERK+C P C +SEW+E C+ C ++ + R E K C P+
Sbjct: 558 PERKSCEIP-CRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQ 616
Query: 434 RPVGEKNCTGPPCDR-QWTVSDWGPCS-----------------GSCGQGRTIRHVYCKT 475
+ C C + W S WGPCS +CG G R V+C
Sbjct: 617 ALQEHRLCNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVK 676
Query: 476 SDGRVVPESQCQMETKPLAIHPC---GDKNCPAHWLAQDWERCNTTCGRG-----VKKRL 527
S V +C T+P + PC K+C + +W C C G +
Sbjct: 677 SHVGQVMTKRCPDSTRPETVRPCFLPCKKDCIVTAFS-EWTPCPRMCQAGNATVKQSRYR 735
Query: 528 VLCMELANGKPQTRSGPECGLAKKPPEESTCFE---RPCFKWYTSPWSEC---------- 574
++ E ANG G EC EE C + P ++W WS C
Sbjct: 736 IIIQEAANG------GQEC--PDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQG 787
Query: 575 ----TKTCGVGVRMRDVKC 589
++ CG G++ R V C
Sbjct: 788 ITGSSEACGKGLQTRAVSC 806
Score = 73.9 bits (180), Expect = 4e-13
Identities = 113/456 (24%), Positives = 162/456 (35%), Gaps = 123/456 (26%)
Query: 285 CSATCTTG-VMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQP-----RWETS 338
C+ C G V S C DG S C RP P C R C +WE S
Sbjct: 21 CTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRP-PKERSCF-RVCDWHSDLFQWEVS 78
Query: 339 SWSECSR----------------TCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVR 382
W C T G Q R+VRC + L+ + V +++CE A++
Sbjct: 79 DWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNR---TVVANEICEHF-ALQ 134
Query: 383 PEERKTCRNPACGPQWEMSE---WSECTAKCGE------RSVVT----RDIRCSE--DEK 427
P + C P C +SE WS C+ CG+ R+V+ ++C + +
Sbjct: 135 PPTEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESR 193
Query: 428 LCD-PNTRPVGEKNCT-----GP-------------PCDRQWTVSDWGPCSG-------- 460
CD P + P+GE+ T GP P R TV D+ S
Sbjct: 194 ACDAPISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGR--TVLDFNSDSNERVTFKHQ 251
Query: 461 -----------SCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPC-GDKNC-PAHW 507
+ G R V C SDG+ S C ++ PL + C K+C + W
Sbjct: 252 SYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQW 311
Query: 508 LAQDWERCNTTCGRG-------VKKRLVLCMELANGK--PQTRSGPECGLAKKPPEESTC 558
W C+ TC G + R V M + GK P+ C + E
Sbjct: 312 --SSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIV-----EGELL 364
Query: 559 FERPCFKWYTSPWSECT----------------KTCGVGVRMRDVKCYQGTDIVRG--CD 600
+ P + W TS W EC CG G++ R+V C Q
Sbjct: 365 QQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAALRAK 424
Query: 601 PLVKPVGRQACDLQPCPTEPPDDSCQDQPGTNCALA 636
+ +PV + C + P P P C T+C ++
Sbjct: 425 EVSRPVEKALC-VGPAPL--PSQLCNIPCSTDCIVS 457
Score = 65.5 bits (158), Expect = 2e-10
Identities = 98/424 (23%), Positives = 151/424 (35%), Gaps = 111/424 (26%)
Query: 277 WKLSSHEPCS-----------------ATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 319
W+ S PCS ATC G+ + CV+ +V C TRP
Sbjct: 634 WETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTRRVFCVKSHVGQVMTKRCPDSTRP 693
Query: 320 EPVHE-FCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAA 378
E V F ++ S W+ C R C G + S Y + + A
Sbjct: 694 ETVRPCFLPCKKDCIVTAFSEWTPCPRMCQAG------------NATVKQSRYRIIIQEA 741
Query: 379 EAVRPE------ERKTCRNPACGP--QWEMSEWSEC--------------TAKCGERSVV 416
E E + C + + P +W+ +WS C + CG + +
Sbjct: 742 ANGGQECPDTLYEERECEDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACG-KGLQ 800
Query: 417 TRDIRCSEDEK--------LCDPNTRPVGEKNCTGPPCDRQWTVSDWG---PCSGSCGQG 465
TR + C D+ L N P+ + CT PC T + W PCS +C
Sbjct: 801 TRAVSCISDDNRSAEMMECLKQTNGMPLLVQECT-VPCREDCTFTAWSKFTPCSTNCEAT 859
Query: 466 RTIRHVYCKTSDGRVVPESQCQ-METKPLA---IHPCGDKNCPAHWLAQ---DWERC--- 515
++ R + G+ + +CQ + PL + PC + +++Q +W C
Sbjct: 860 KSRR----RQLTGKSRKKEKCQDSDLYPLVETELCPCDE------FISQPYGNWSDCILP 909
Query: 516 ---------------NTTCGRGVKKRLVLCMELANGKPQTRSG-PECGLAKKPPEESTCF 559
+ CG G++ R V C + NG+P S G ++ F
Sbjct: 910 EGRREPHRGLRVQADSKECGEGLRFRAVACSD-KNGRPVDPSFCSSSGYIQEKCVIPCPF 968
Query: 560 ERPCFKWYTSPWSECTKTCGVGVRMRD----VKCYQGTDIVRGCDPLVKPVGRQACDLQP 615
+ W S W C+ +CG+GVR+R K Y G R C L Q + P
Sbjct: 969 DCKLSDW--SSWGSCSSSCGIGVRIRSKWLKEKPYNGG---RPCPKLDLKNQAQVHEAVP 1023
Query: 616 CPTE 619
C +E
Sbjct: 1024 CYSE 1027
Score = 62.4 bits (150), Expect = 1e-09
Identities = 88/358 (24%), Positives = 124/358 (34%), Gaps = 89/358 (24%)
Query: 282 HEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWS 341
H S G + C R DG S C + P V ++C+ + SSWS
Sbjct: 257 HHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETS-QWSSWS 315
Query: 342 ECSRTCGEGYQFRVVRCWKMLSPGFDSS----VYSDLCEAAEAVRPEERKTC------RN 391
CS+TC G L PGF S + + E E++ C
Sbjct: 316 PCSKTCRSG----------SLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQ 365
Query: 392 PACGPQWEMSEWSECTAK----------------CGERSVVTRDIRCSEDEKL-----CD 430
W SEW EC CG + TR++ C++
Sbjct: 366 QCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCG-GGIQTREVYCAQSVPAAAALRAK 424
Query: 431 PNTRPVGEKNCTGP----------PCDRQWTVSD---WGPC--------SGSCGQGRTIR 469
+RPV + C GP PC VS WG C G G R
Sbjct: 425 EVSRPVEKALCVGPAPLPSQLCNIPCSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQR 484
Query: 470 HVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERC---NTTCGRGVKKR 526
HV +++ P C + + PC D C WLA + C + CG G +
Sbjct: 485 HVLMESTG----PAGHCPHLVESV---PCEDPMC-YRWLASE-GICFPDHGKCGLGHRIL 535
Query: 527 LVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC------FKWYTSPWSECTKTC 578
+C N + + SG C + PPE +C E PC +W + WS C+++C
Sbjct: 536 KAVCQ---NDRGEDVSGSLCPV-PPPPERKSC-EIPCRMDCVLSEW--TEWSSCSQSC 586
Score = 57.8 bits (138), Expect = 3e-08
Identities = 83/339 (24%), Positives = 128/339 (37%), Gaps = 64/339 (18%)
Query: 275 YRWKLSSHEPC----SATCTTGVMSAYAMCVRYDGVEVDDSYCDA--LTRPEPVHEFCAG 328
+++ L+ C +A C GV + CV DG V C+ L +P+ + C
Sbjct: 1154 FQYNLTEWSTCQLSENAPCGQGVRTRLLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLV 1213
Query: 329 RECQPRWETS---SWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE 385
EC + S +W+ECS+TCG G + R M + G ++L +
Sbjct: 1214 -ECVVNCQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTELTQ--------- 1263
Query: 386 RKTCRNPACGPQWEMSEWSECTAK---CGERSVVTRDIRCSE------------DEKLCD 430
KTC C W + WS C + CGE V R + C ++ LC
Sbjct: 1264 EKTCPVTPCY-SWVLGNWSACKLEGGDCGE-GVQIRSLSCMVHSGSISHAAGRVEDALCG 1321
Query: 431 --PNTRPVGEKNCTGP-PCDRQWTV-SDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQC 486
P + ++ C+ P P D T S+W C +C GR+ V ++ + +S
Sbjct: 1322 EMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFE 1381
Query: 487 QMETKP---LAIHPCGDKNCPAH-WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRS 542
++ P L PC C + W A W +R V C + ++G T
Sbjct: 1382 NQDSCPQQVLETRPCTGGKCYHYTWKASLWNN---------NERTVWC-QRSDGVNVTGG 1431
Query: 543 GPECGLAKKPPEESTCFERPCFKWYTSPWSECTK--TCG 579
C P+ R C P+S CT+ CG
Sbjct: 1432 ---CS-----PQARPAAIRQCIPACRKPFSYCTQGGVCG 1462
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/192 (27%), Positives = 71/192 (36%), Gaps = 40/192 (20%)
Query: 455 WGPCSGSCGQGRT-IRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH-----WL 508
WG C+G CG G R V+C DG S C +P C + C H W
Sbjct: 18 WGRCTGDCGPGGVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCF-RVCDWHSDLFQWE 76
Query: 509 AQDWERCN----------------TTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKP 552
DW C T G++ R+V C++ N E A +P
Sbjct: 77 VSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICE-HFALQP 135
Query: 553 PEESTCF---ERPCFKWYTSPWSECTKTCGVGVRMR-----------DVKCYQGTDIVRG 598
P E C R C PWS C+K CG ++ R ++C T+ R
Sbjct: 136 PTEQACLIPCPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTE-SRA 194
Query: 599 CD-PLVKPVGRQ 609
CD P+ P+G +
Sbjct: 195 CDAPISCPLGEE 206
Score = 51.6 bits (122), Expect = 2e-06
Identities = 44/153 (28%), Positives = 62/153 (40%), Gaps = 33/153 (21%)
Query: 495 IHPCGDKNCPAHWLAQDWERCNTTCG-RGVKKRLVLCMELANGKPQTRSGPECGLAKKPP 553
+H D+ H LA W RC CG GV+ R V C + T CG + +PP
Sbjct: 1 MHNTADEVVLYHKLAGPWGRCTGDCGPGGVQSRAVWCFHVDG---WTSHLSNCGESNRPP 57
Query: 554 EESTCFERPC------FKWYTSPWSECT----------------KTCGVGVRMRDVKCYQ 591
+E +CF R C F+W S W C T G++ R V+C Q
Sbjct: 58 KERSCF-RVCDWHSDLFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQ 116
Query: 592 GTDIVRGCDPL-----VKPVGRQACDLQPCPTE 619
+ + + ++P QAC L PCP +
Sbjct: 117 KLNRTVVANEICEHFALQPPTEQAC-LIPCPRD 148
Score = 44.7 bits (104), Expect = 3e-04
Identities = 41/156 (26%), Positives = 62/156 (39%), Gaps = 38/156 (24%)
Query: 340 WSECSRTCGEG-YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGP-- 396
W C+ CG G Q R V C+ + S L E+ RP + ++C
Sbjct: 18 WGRCTGDCGPGGVQSRAVWCFHV------DGWTSHLSNCGESNRPPKERSCFRVCDWHSD 71
Query: 397 --QWEMSEWSEC-------------TAKC--GERSVVTRDIRCSED-------EKLCDP- 431
QWE+S+W C TA+C + + R +RC + ++C+
Sbjct: 72 LFQWEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHF 131
Query: 432 NTRPVGEKNCTGPPCDRQWTVSD---WGPCSGSCGQ 464
+P E+ C PC R VS+ W CS CG+
Sbjct: 132 ALQPPTEQACL-IPCPRDCVVSEFLPWSNCSKGCGK 166
Score = 37.7 bits (86), Expect = 0.034
Identities = 48/210 (22%), Positives = 72/210 (34%), Gaps = 31/210 (14%)
Query: 275 YRWKLSSHEPCS---ATCTTGVMSAYAMCVRYDGV------EVDDSYCDALTRPEPVHEF 325
Y W L + C C GV C+ + G V+D+ C + + + +
Sbjct: 1273 YSWVLGNWSACKLEGGDCGEGVQIRSLSCMVHSGSISHAAGRVEDALCGEMPFQDSILKQ 1332
Query: 326 CAGRECQPRW---ETSSWSECSRTCGEGYQFRVV----RCWKMLSPGFDSSVYSDLCEAA 378
C E S WS C TC +G F V R + F++ D C
Sbjct: 1333 LCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFIIQSFEN---QDSCPQ- 1388
Query: 379 EAVRPEERKTCRNPAC-GPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVG 437
+ E + C C W+ S W+ ER+V + C P RP
Sbjct: 1389 ---QVLETRPCTGGKCYHYTWKASLWNN-----NERTVWCQRSDGVNVTGGCSPQARPAA 1440
Query: 438 EKNCTGPPCDRQWTVSDWGPCSGSCGQGRT 467
+ C P C + ++ G G C +G T
Sbjct: 1441 IRQCI-PACRKPFSYCTQGGVCG-CEKGYT 1468
>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
sapiens]
Length = 1657
Score = 100 bits (249), Expect = 4e-21
Identities = 98/353 (27%), Positives = 137/353 (38%), Gaps = 50/353 (14%)
Query: 271 PADMYRWKLSSHEPCSATCTTGVM--SAYAMCVRYDG----VEVDDSYCDALTRPEPVHE 324
P+D + S+ CS +C +GV S + Y+G ++D + P H
Sbjct: 1033 PSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHS 1092
Query: 325 FCAGRECQPRWETSSWSECSRT-------CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
C Q W T WS C T CGEG Q R VRC + + G V LC+
Sbjct: 1093 DCN----QYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDP 1148
Query: 378 AEAVRPEERKTCRNPACGPQWEMSEW---SECTAKCGERSVVTRD---IRCSEDEKLCDP 431
E P + C+ P C +SEW ++C C + S R IR DE P
Sbjct: 1149 EEM--PLGSRVCKLP-CPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCP 1205
Query: 432 NTRPVGEKNCTGPPCDRQWTVSDWGPCSGS----CGQGRTIRHVYCKTSDGRVVPESQCQ 487
N N + V+DW C S CG G R + C SDG+ V C+
Sbjct: 1206 NAVEKEPCNLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCE 1265
Query: 488 ME--TKPLAIHPCGDKNCPAHWLAQDWE---RCNTTCG---RGVKKRLVLCMELANGKPQ 539
K ++ CP + DW C+ TCG + +++R V +G+P
Sbjct: 1266 ALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPC 1325
Query: 540 TRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECT---KTCGVGVRMRDVKC 589
P KP C +PC++W WS C CG G R R++ C
Sbjct: 1326 ----PSLMDQSKP-----CPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISC 1369
Score = 97.8 bits (242), Expect = 3e-20
Identities = 96/368 (26%), Positives = 148/368 (40%), Gaps = 58/368 (15%)
Query: 289 CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCG 348
C G C +G V+ S C++ E +C+ E S+WS CS++CG
Sbjct: 994 CGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLS-EWSNWSRCSKSCG 1052
Query: 349 EGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTA 408
G + R W P ++ + + E C + W WS C
Sbjct: 1053 SGVKVRSK--WLREKP-YNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKV 1109
Query: 409 -------KCGERSVVTRDIRCSE----------DEKLCDPNTRPVGEKNCTGPPCDRQWT 451
CGE V TR +RC + ++ LCDP P+G + C PC
Sbjct: 1110 TFVNMRENCGE-GVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCK-LPCPEDCV 1167
Query: 452 VSDWGP-------CSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 504
+S+WGP C+ S + R+ + +GR P + +E +P ++ KNC
Sbjct: 1168 ISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA---VEKEPCNLN----KNCY 1220
Query: 505 AH-WLAQDWERCNTT----CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF 559
+ + DW C + CG G+K R++ C+ + GL K ++C
Sbjct: 1221 HYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCM 1280
Query: 560 -ERP--CFKWYTSPWSECTKTCGVG---VRMRDV-KCYQGTDIVRGCDPLVKPVGRQACD 612
E P C SPWSEC++TCG+ +R R V + +QG R C L+
Sbjct: 1281 VECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDG--RPCPSLMD-------Q 1331
Query: 613 LQPCPTEP 620
+PCP +P
Sbjct: 1332 SKPCPVKP 1339
Score = 76.6 bits (187), Expect = 7e-14
Identities = 85/365 (23%), Positives = 127/365 (34%), Gaps = 106/365 (29%)
Query: 335 WETSSWSEC----------------SRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC--E 376
W T+ W+EC + CG G Q R V C + + ++ S L +
Sbjct: 427 WRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQA-----NENLLSQLSTHK 481
Query: 377 AAEAVRPEERKTCRNPA----------CGPQWEMSEWS--------ECTAKCGERSVVTR 418
EA +P + K C P C + E+S WS C + G++ R
Sbjct: 482 NKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCTYENCNDQQGKKGFKLR 541
Query: 419 DIRCSEDEKLCDPNTRPVGEKNCTGP--------PCDR----QWTVSDWGPCSGS----C 462
R + + P G TG PC+ W G C C
Sbjct: 542 KRRITNE---------PTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKEC 592
Query: 463 GQGRTIRHVYCKTSDGRVVPESQCQMETKPLAI---HPCGDKNCPAHWLAQDWERCNTTC 519
G G ++ V C SDG V C+ P+ + PC + W W C+ TC
Sbjct: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTW--STWSSCSHTC 650
Query: 520 ------GRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPW 571
G+ ++ R +L G G C + E +C E PC + W T PW
Sbjct: 651 SGKTTEGKQIRARSILAYAGEEG------GIRCPNSSALQEVRSCNEHPCTVYHWQTGPW 704
Query: 572 SECTK-----------------TCGVGVRMRDVKCYQ---GTDIVRGCDPLVKPVGRQAC 611
+C + +C VG++ R V C + G + C ++P + C
Sbjct: 705 GQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPC 764
Query: 612 DLQPC 616
L PC
Sbjct: 765 -LLPC 768
Score = 71.2 bits (173), Expect = 3e-12
Identities = 86/386 (22%), Positives = 136/386 (35%), Gaps = 98/386 (25%)
Query: 273 DMYRWKLSSHEPCSATCTT-------------GVMSAYAMCVRYD-GVEVDDSYCDALTR 318
++Y W+L C + G+ C++ D + +D C+
Sbjct: 120 ELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF-E 178
Query: 319 PEPVHEFCAGRECQPRW---ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLC 375
P+P+ E CQ E S+WSECS+TCG G Q R + P F S +L
Sbjct: 179 PKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHV--VAPPQFGGSGCPNLT 236
Query: 376 EAAEAVRPEERKTCRNPACGPQ-----WEMSEWSECT------AKCGERSVVTRDIRCSE 424
E + C++ C + + WS C+ + R ++
Sbjct: 237 EF---------QVCQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDR 287
Query: 425 DEKLCDPNTRPVGEKNCTGPPCDRQ----WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRV 480
+ + DP R + +K +RQ W + G R V C G+
Sbjct: 288 SKGVKDPEARELIKKKRNRNRQNRQENKYWDIQ----------IGYQTREVMCINKTGKA 337
Query: 481 VPESQCQMETKPLAIHPCG-DKNCP-AHWLAQDWERCNTTC-------GRGVKKRLVLCM 531
S CQ E P+ C K C + W +W C+ TC G V+ R +
Sbjct: 338 ADLSFCQQEKLPMTFQSCVITKECQVSEW--SEWSPCSKTCHDMVSPAGTRVRTRTIRQF 395
Query: 532 ELANGKPQTRSGPECGLAKKPPEESTCFER-----PC--FKWYTSPWSEC---------- 574
+ + K EC + E+ C + PC + W T+ W+EC
Sbjct: 396 PIGSEK-------EC---PEFEEKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQD 445
Query: 575 ------TKTCGVGVRMRDVKCYQGTD 594
T CG G++ R+V C Q +
Sbjct: 446 KRRGNQTALCGGGIQTREVYCVQANE 471
Score = 70.9 bits (172), Expect = 4e-12
Identities = 88/364 (24%), Positives = 134/364 (36%), Gaps = 82/364 (22%)
Query: 287 ATCTTGVMSAYAMCVRYDGVEVDDSYCDA--LTRPEPVHEFCAGRECQPRWETSS---WS 341
A C G+ + CVR DG VD YC+A L + ++ C EC + S WS
Sbjct: 1238 AVCGNGIKTRMLDCVRSDGKSVDLKYCEALGLEKNWQMNTSCM-VECPVNCQLSDWSPWS 1296
Query: 342 ECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMS 401
ECS+TC G +++R + P F C + ++ K C C +W+
Sbjct: 1297 ECSQTC--GLTGKMIRRRTVTQP-FQGD--GRPCPSL----MDQSKPCPVKPC-YRWQYG 1346
Query: 402 EWSEC---TAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC 458
+WS C A+CGE TR+I C + D ++ V E+ C
Sbjct: 1347 QWSPCQVQEAQCGE-GTRTRNISCVVSDGSADDFSKVVDEEFC----------------- 1388
Query: 459 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT 518
+D ++ + M + PC W W C T
Sbjct: 1389 -----------------ADIELIIDGNKNMVLEESCSQPCPGDCYLKDW--SSWSLCQLT 1429
Query: 519 CGRG---------VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTS 569
C G V+ R V+ EL N PE L K + C+E +KW S
Sbjct: 1430 CVNGEDLGFGGIQVRSRPVIIQELEN----QHLCPEQMLETKSCYDGQCYE---YKWMAS 1482
Query: 570 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQP 629
W ++T V + D G ++ GC + +P ++C+ PC P C +
Sbjct: 1483 AWKGSSRT--VWCQRSD-----GINVTGGCLVMSQPDADRSCN-PPC--SQPHSYCSETK 1532
Query: 630 GTNC 633
+C
Sbjct: 1533 TCHC 1536
Score = 63.5 bits (153), Expect = 6e-10
Identities = 99/376 (26%), Positives = 139/376 (36%), Gaps = 86/376 (22%)
Query: 275 YRWK---LSSHEPCSAT-CTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVH-EFCAGR 329
Y WK L + EP + C G +C+ DG EVD C P PV + +
Sbjct: 574 YDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPK 633
Query: 330 EC-QPRWETSSWSECSRTC-GEGYQFRVVRCWKMLS-PGFDSSVYSDLCEAAEAVRPEER 386
+C W S+WS CS TC G+ + + +R +L+ G + + C + A++ E R
Sbjct: 634 DCVLSTW--STWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI---RCPNSSALQ-EVR 687
Query: 387 KTCRNPACGPQWEMSEWSEC------------TAKCGERS----VVTRDIRC------SE 424
+P W+ W +C T GE S + TR + C
Sbjct: 688 SCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQV 747
Query: 425 DEKLCDPNTRPVGEKNCTGPPCDRQWTV---SDWGPCSGSCGQG-RTIRHVYCKTSDGRV 480
K C + RP + C PC + V SDW C SC +G +IR K S RV
Sbjct: 748 GPKKCPESLRPETVRPCL-LPCKKDCIVTPYSDWTSCPSSCKEGDSSIR----KQSRHRV 802
Query: 481 V---PESQCQMETKPLAIHPCGDKNCPA-------HWLAQDWERCNTT------------ 518
+ P + + T PL +K C A W W RC
Sbjct: 803 IIQLPANGGRDCTDPL----YEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQ 858
Query: 519 --CGRGVKKRLVLCMELANGKPQTRSGPEC-GLAKKPPEESTCFERPC------FKWYTS 569
CG G + R + C + G+ EC A P + + PC W S
Sbjct: 859 EGCGPGRQARAITCRKQDGGQAGIH---ECLQYAGPVPALTQACQIPCQDDCQLTSW--S 913
Query: 570 PWSECTKTCGVGVRMR 585
+S C CG VR R
Sbjct: 914 KFSSCNGDCG-AVRTR 928
Score = 48.5 bits (114), Expect = 2e-05
Identities = 90/418 (21%), Positives = 134/418 (32%), Gaps = 106/418 (25%)
Query: 252 GNRTHKARTRPKARKQGVSPADMYRWKLSSHEPC-----------------SATCTTGVM 294
G R + + R P +Y W+ C A+C+ G+
Sbjct: 674 GIRCPNSSALQEVRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQ 733
Query: 295 SAYAMCVRYDGVEVDDSYCDALTRPEPVHE--FCAGRECQPRWETSSWSECSRTCGEGYQ 352
+ +CVR + +V C RPE V ++C S W+ C +C EG
Sbjct: 734 TRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVT-PYSDWTSCPSSCKEG-- 790
Query: 353 FRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGE 412
DSS+ + R + PA G + +CT E
Sbjct: 791 --------------DSSIRK---------QSRHRVIIQLPANGGR-------DCTDPLYE 820
Query: 413 RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP-CSGSCGQGRTIRHV 471
C + + + C P W+V P CG GR R +
Sbjct: 821 EKA------CEAPQACQSYRWKTHKWRRCQLVP----WSVQQDSPGAQEGCGPGRQARAI 870
Query: 472 YCKTSDGRVVPESQCQMETKPLAI------HPCGDKNCPAHWLAQDWERCNTTCG--RGV 523
C+ DG +C P+ PC D W + CN CG R
Sbjct: 871 TCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSW--SKFSSCNGDCGAVRTR 928
Query: 524 KKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSP---WSEC------ 574
K+ LV GK + + +C + P T + PC K+ P WS+C
Sbjct: 929 KRTLV-------GKSKKKE--KCKNSHLYPLIETQY-CPCDKYNAQPVGNWSDCILPEGK 978
Query: 575 ------------TKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCPTE 619
K CG G R + + CY Q +V +AC + PCP++
Sbjct: 979 VEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEAC-IIPCPSD 1035
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/135 (25%), Positives = 54/135 (40%), Gaps = 29/135 (21%)
Query: 507 WLAQDWERC-NTTCGRG-VKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFE---- 560
W W RC CG G ++ R V C A+ + T C A++P + CF+
Sbjct: 61 WKTGPWGRCMGDECGPGGIQTRAVWC---AHVEGWTTLHTNCKQAERPNNQQNCFKVCDW 117
Query: 561 -RPCFKWYTSPWSECTKTCG-------------VGVRMRDVKCYQGTDIVRGCDPLV--- 603
+ + W PW++C G+++R++ C Q + D +
Sbjct: 118 HKELYDWRLGPWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYF 177
Query: 604 --KPVGRQACDLQPC 616
KP+ QAC L PC
Sbjct: 178 EPKPLLEQAC-LIPC 191
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 89.4 bits (220), Expect = 1e-17
Identities = 60/204 (29%), Positives = 83/204 (40%), Gaps = 27/204 (13%)
Query: 445 PCDRQWTVSDWGPCSGSCGQGRTIRHVYC-KTSDGRVVPESQCQ-----METKPLAIHPC 498
P +W +D+ PCS +CG G + C RVV + C ++ KP + C
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKP-KLQEC 354
Query: 499 GDKNCPA-----------------HWLAQDWERCNTTCGRGVKKRLVLCMEL-ANGKPQT 540
CPA W A W C+++CG G++ R V C+E G +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
Query: 541 RSGPECGLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDI-VRGC 599
+C K P C C KW WS CT TCG G+R R V C + GC
Sbjct: 415 VEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 600 DPLVKPVGRQACDLQPCPTEPPDD 623
P KP ++ C + P P P +
Sbjct: 475 SPKTKPHIKEEC-IVPTPCYKPKE 497
Score = 85.1 bits (209), Expect = 2e-16
Identities = 67/237 (28%), Positives = 93/237 (39%), Gaps = 47/237 (19%)
Query: 334 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 393
RW + + CS TCG GYQ C+ + S + Y E ++P+
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYP--ENIKPK--------- 348
Query: 394 CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVS 453
P+ + C A G + ++ D L P R W +
Sbjct: 349 --PKLQECNLDPCPASDGYKQIMPYD--------LYHPLPR---------------WEAT 383
Query: 454 DWGPCSGSCGQGRTIRHVYCKTSD--GRV--VPESQCQMETKPLAIHPCGDKNCPAHWLA 509
W CS SCG G R V C D G V V E +C K PC +CP WLA
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLA 442
Query: 510 QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCF-ERPCFK 565
Q+W C TCG+G++ R+VLC++ + G C KP + C PC+K
Sbjct: 443 QEWSPCTVTCGQGLRYRVVLCID---HRGMHTGG--CSPKTKPHIKEECIVPTPCYK 494
Score = 77.4 bits (189), Expect = 4e-14
Identities = 60/200 (30%), Positives = 85/200 (42%), Gaps = 32/200 (16%)
Query: 274 MYRWKLSSHEPCSATCTTGVMSAYAMC--VRYDGVEVDDSYCDALT---RPEPVHEFCAG 328
++RW+ + PCSATC G A C +R + V V D YC +P+P + C
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV-VADQYCHYYPENIKPKPKLQECNL 356
Query: 329 RECQ-----------------PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 371
C PRWE + W+ CS +CG G Q R V C + G +SV
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 372 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKL--- 428
C + + C C P+W EWS CT CG+ + R + C + +
Sbjct: 417 EWKC--MYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDHRGMHTG 472
Query: 429 -CDPNTRPVGEKNCTGP-PC 446
C P T+P ++ C P PC
Sbjct: 473 GCSPKTKPHIKEECIVPTPC 492
Score = 37.4 bits (85), Expect = 0.044
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 15/69 (21%)
Query: 340 WSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWE 399
WSECSRTCG G + + RC + S CE R +TC N C P+
Sbjct: 42 WSECSRTCGGGASYSLRRC-----------LSSKSCEG----RNIRYRTCSNVDCPPEAG 86
Query: 400 MSEWSECTA 408
+C+A
Sbjct: 87 DFRAQQCSA 95
Score = 32.3 bits (72), Expect = 1.4
Identities = 17/57 (29%), Positives = 25/57 (43%), Gaps = 6/57 (10%)
Query: 570 PWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPDDSCQ 626
PWSEC++TCG G +C + C+ + + + C CP E D Q
Sbjct: 41 PWSECSRTCGGGASYSLRRCLSS----KSCEG--RNIRYRTCSNVDCPPEAGDFRAQ 91
Score = 30.0 bits (66), Expect = 7.1
Identities = 14/59 (23%), Positives = 22/59 (37%), Gaps = 2/59 (3%)
Query: 273 DMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC 331
D +W PC+ TC G+ +C+ + G+ C T+P E C
Sbjct: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGG--CSPKTKPHIKEECIVPTPC 492
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 83.2 bits (204), Expect = 7e-16
Identities = 80/291 (27%), Positives = 111/291 (38%), Gaps = 45/291 (15%)
Query: 338 SSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQ 397
S W EC+R CG G Q R C + +PG + CE EE + C ACGP
Sbjct: 268 SLWGECTRDCGGGLQTRTRTC--LPAPGVEGGG----CEGV----LEEGRQCNREACGP- 316
Query: 398 WEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGP 457
+ RS R E+L D + TG P +W S W
Sbjct: 317 ---------AGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEW--SPWSV 365
Query: 458 CSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKN-CPAHWLAQD---WE 513
CS +CG+G R +C +S +QC + + C + CP H + W
Sbjct: 366 CSSTCGEGWQTRTRFCVSSS----YSTQCSGPLREQRL--CNNSAVCPVHGAWDEWSPWS 419
Query: 514 RCNTTCGRGVKKRLVLCMELANGKPQTRSGPE-----CGLAKKPPEESTCFERPCFKWYT 568
C++TCGRG + R C G GPE C +A P + +W
Sbjct: 420 LCSSTCGRGFRDRTRTCRPPQFG-GNPCEGPEKQTKFCNIALCP---GRAVDGNWNEW-- 473
Query: 569 SPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTE 619
S WS C+ +C G + R +C G + V + C LQ CP +
Sbjct: 474 SSWSACSASCSQGRQQRTREC--NGPSYGGAECQGHWVETRDCFLQQCPVD 522
Score = 83.2 bits (204), Expect = 7e-16
Identities = 78/247 (31%), Positives = 99/247 (40%), Gaps = 44/247 (17%)
Query: 336 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 395
E S WS CS TCGEG+Q R C SS YS C E++ C N A
Sbjct: 359 EWSPWSVCSSTCGEGWQTRTRFC--------VSSSYSTQCSGP----LREQRLCNNSAVC 406
Query: 396 P---QW-EMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKN------CTGPP 445
P W E S WS C++ CG R R C + +P P + C G
Sbjct: 407 PVHGAWDEWSPWSLCSSTCG-RGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRA 465
Query: 446 CDRQWTV-SDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQ---METKPLAIHPCGDK 501
D W S W CS SC QGR R C +G ++CQ +ET+ C +
Sbjct: 466 VDGNWNEWSSWSACSASCSQGRQQRTREC---NGPSYGGAECQGHWVETR-----DCFLQ 517
Query: 502 NCP--AHWLA-QDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGP-----ECGLAKKPP 553
CP W A W C+ TCG G ++R +C G + GP +CG + P
Sbjct: 518 QCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQ-GPQDEYRQCGTQRCPE 576
Query: 554 EESTCFE 560
C E
Sbjct: 577 PHEICDE 583
Score = 46.2 bits (108), Expect = 1e-04
Identities = 59/231 (25%), Positives = 88/231 (38%), Gaps = 33/231 (14%)
Query: 398 WEM-SEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWG 456
W++ S W ECT CG + TR C + V E+ G C+R+ G
Sbjct: 264 WKLWSLWGECTRDCGG-GLQTRTRTCLPAPGVEGGGCEGVLEE---GRQCNREAC----G 315
Query: 457 PCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCN 516
P + + +++R ++D R E +++ GD PA W C+
Sbjct: 316 PAGRTSSRSQSLR-----STDARRREELGDELQQFGFPAPQTGD---PAAEEWSPWSVCS 367
Query: 517 TTCGRGVKKRLVLCMELANGKPQTRSGPE-----CGLAKKPPEESTCFERPCFKWYTSPW 571
+TCG G + R C+ ++ SGP C + P E W SPW
Sbjct: 368 STCGEGWQTRTRFCV--SSSYSTQCSGPLREQRLCNNSAVCPVHGAWDE-----W--SPW 418
Query: 572 SECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 622
S C+ TCG G R R C C+ K + C++ CP D
Sbjct: 419 SLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQT--KFCNIALCPGRAVD 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.445
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,011,434
Number of Sequences: 37866
Number of extensions: 1791326
Number of successful extensions: 5696
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 3998
Number of HSP's gapped (non-prelim): 570
length of query: 660
length of database: 18,247,518
effective HSP length: 109
effective length of query: 551
effective length of database: 14,120,124
effective search space: 7780188324
effective search space used: 7780188324
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.