Search of human proteins with 11138123

Search of human proteins with 11138123

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
sapiens]
         (450 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   917   0.0  
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   496   e-140
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   328   6e-90
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   305   7e-83
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   303   3e-82
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    302   5e-82
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   294   1e-79
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     289   3e-78
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   285   6e-77
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   283   2e-76
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   281   9e-76
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   280   1e-75
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   279   3e-75
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   242   4e-64
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              232   5e-61
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   232   5e-61
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   231   1e-60
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   229   4e-60
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   222   6e-58
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   217   2e-56
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   211   1e-54
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              178   8e-45
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   168   1e-41
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   155   9e-38
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   137   3e-32
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...    91   2e-18
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...    81   2e-15
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso...    81   2e-15
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...    80   4e-15
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...    80   4e-15

>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  917 bits (2370), Expect = 0.0
 Identities = 450/450 (100%), Positives = 450/450 (100%)

Query: 1   MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE 60
           MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE
Sbjct: 1   MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLE 60

Query: 61  VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN 120
           VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN
Sbjct: 61  VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYN 120

Query: 121 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH 180
           KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH
Sbjct: 121 KADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH 180

Query: 181 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV 240
           QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV
Sbjct: 181 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV 240

Query: 241 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK 300
           CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK
Sbjct: 241 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGK 300

Query: 301 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS 360
           YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS
Sbjct: 301 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQS 360

Query: 361 RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK 420
           RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK
Sbjct: 361 RPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWK 420

Query: 421 RLARVMDRFFLAIFFSMALVMSLLVLVQAL 450
           RLARVMDRFFLAIFFSMALVMSLLVLVQAL
Sbjct: 421 RLARVMDRFFLAIFFSMALVMSLLVLVQAL 450


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  496 bits (1278), Expect = e-140
 Identities = 250/453 (55%), Positives = 322/453 (71%), Gaps = 28/453 (6%)

Query: 25  AEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQ 84
           A+G+ A KLF DLF +Y++ALRPV DTD+ LNVTL++TLSQI DMDERNQ+LT YLWIRQ
Sbjct: 26  ADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQ 85

Query: 85  EWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRW 144
            W DAYL WD + Y GLD+IRIPS LVWRPDIVLYNKAD +     +TNVVLR+DG + W
Sbjct: 86  IWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITW 145

Query: 145 DAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRV 204
           DAPAIT+SSC VDV  FPFD Q C LTFGSWT+ G+Q+D+     +  L+DF+E+VEW V
Sbjct: 146 DAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEV 205

Query: 205 LGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADS 264
            GMPA + V++YGCCSEPYPDVTFTLLL+RR++ Y+ NLL+PCVLIS LAPL+F+LPA S
Sbjct: 206 HGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAAS 265

Query: 265 GEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHY 324
           GEKVSLGVT+LLA+TVFQL++AE MP +E+VPLIGKYY+ATM ++T STALTI++MN+H+
Sbjct: 266 GEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHF 325

Query: 325 CGPSVRPVPAWARALLLGHLARGLCVRERGEPC---GQSRPPE-----LSPSPQSP---- 372
           CG   RPVP WAR ++L +++R L V + GE C     SR  +      S  P+S     
Sbjct: 326 CGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAA 385

Query: 373 ---------------EGGAGPPAGPCHEPRCLCRQ-EALLHHVATIANTFRSHRAAQRCH 416
                          +   G       E    C Q + L  ++  IA   + H+A     
Sbjct: 386 RNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKG 445

Query: 417 EDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449
            +WK++A+V+DRFF+ IFF M  VM++L++ +A
Sbjct: 446 SEWKKVAKVIDRFFMWIFFIMVFVMTILIIARA 478


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  328 bits (841), Expect = 6e-90
 Identities = 183/471 (38%), Positives = 262/471 (55%), Gaps = 49/471 (10%)

Query: 26  EGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQE 85
           +G    KL+++L  NY    RPVA+  Q L V   ++L QI+D+DE+NQVLT  +W++  
Sbjct: 22  QGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMS 81

Query: 86  WTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWD 145
           WTD YL+W+ + Y G+  +R P   +W+PDI+LYN AD +   +  TNV++   G  ++ 
Sbjct: 82  WTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYL 141

Query: 146 APAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVL 205
            P I +SSC +DV  FPFD QHC L FGSW++GG  LD++ +   A ++ ++ N EW ++
Sbjct: 142 PPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQ--EADISGYIPNGEWDLV 199

Query: 206 GMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSG 265
           G+P +R    Y CC EPYPDVTFT+ +RRR   Y  NLL+PCVLIS LA L F LPADSG
Sbjct: 200 GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSG 259

Query: 266 EKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIMNLHY 324
           EK+SLG+TVLL+LTVF LL+AE MP  ++SVPLI +Y+ +TM +V  S  +T++++  H+
Sbjct: 260 EKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHH 319

Query: 325 CGPSVRPVPAWARALLLGHLARGLCVRERGE----PCGQSRPPELSPSPQSPEGGAGPPA 380
             P    +P W R +LL   A  L ++  GE    P  Q +    S +       A PPA
Sbjct: 320 HDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPA 379

Query: 381 G------------------PCHEPRCLC--------RQEALLH----------------H 398
                              P  +   +C          E LLH                 
Sbjct: 380 SNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEE 439

Query: 399 VATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449
           V  IAN FR    ++    +WK  A V+DR  L  F    ++ ++ +L+ A
Sbjct: 440 VRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  305 bits (780), Expect = 7e-83
 Identities = 172/484 (35%), Positives = 266/484 (54%), Gaps = 49/484 (10%)

Query: 12  LLLLFLLP-AECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMD 70
           LLLL LLP A    AE RL    F  LF +Y   +RPVA+    + +  EV++SQ++ +D
Sbjct: 20  LLLLSLLPVARASEAEHRL----FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVD 75

Query: 71  ERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSA 130
           E NQ++   LW++Q W D  L+W+P+ YGG + +R+P+  +W+PDIVLYN A        
Sbjct: 76  EVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDD 135

Query: 131 STNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAA 190
            T  +L++ G V W  PAI +SSC++DV  FPFD Q+C + FGSW++   ++D+   G++
Sbjct: 136 KTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSS 195

Query: 191 ASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLI 250
            +L D+ E+ EW ++  P  +  + Y CC E YPD+T++L +RR    Y  NL++PC+LI
Sbjct: 196 MNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLI 255

Query: 251 SLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMV 309
           S L  L F+LP+D GEKV+L ++VLL+LTVF L++ E++P    V PLIG+Y + TM  V
Sbjct: 256 SFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFV 315

Query: 310 TFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPP------ 363
           T S  +T+ ++N+HY  P+   +P+W + + L  L R + +       G ++ P      
Sbjct: 316 TLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGA 375

Query: 364 ELS-----PSPQSPEGGAGPP-----AGPCHEPRC--------LCRQEA----------- 394
           ELS        +S     G P      G CH  R         L R  +           
Sbjct: 376 ELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLS 435

Query: 395 --------LLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVL 446
                    +  V  IA   ++   A+   +DWK +A V+DR FL +F  + ++ +  + 
Sbjct: 436 ALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLF 495

Query: 447 VQAL 450
           +Q L
Sbjct: 496 LQPL 499


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  303 bits (775), Expect = 3e-82
 Identities = 165/448 (36%), Positives = 237/448 (52%), Gaps = 45/448 (10%)

Query: 32  KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYL 91
           +LF+ LF  Y    RPV +T   + V   ++++Q+ID+DE+NQ++T  +W++QEW+D  L
Sbjct: 61  RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 120

Query: 92  RWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITR 151
           RW+P  +G + ++R+PS ++W PDIVLYN AD +   +  T   L   G V W  PAI +
Sbjct: 121 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 180

Query: 152 SSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARR 211
           SSC +DV  FPFD Q+C + FGSWT+   ++D+        L D+ E+ EW ++      
Sbjct: 181 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 240

Query: 212 RVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLG 271
               Y CC+E YPDVT+  ++RR    Y  NL++PC+LIS L  L F+LP+D GEK++L 
Sbjct: 241 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 300

Query: 272 VTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVR 330
           ++VLL+LTVF LL+ E +P    V PLIG+Y + TM  VT S  +T+ ++N+H+  PS  
Sbjct: 301 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 360

Query: 331 PVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQ-------------------- 370
            +P W R  LLG + R L +     P     P  L  SP                     
Sbjct: 361 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 420

Query: 371 ---------SPEGGAGPPAGPCHEPRCLCRQEALLHH---------------VATIANTF 406
                    +P  G     G  H      + EALL                 V  IA+  
Sbjct: 421 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 480

Query: 407 RSHRAAQRCHEDWKRLARVMDRFFLAIF 434
           RS  A     EDWK +A V+DR FL +F
Sbjct: 481 RSEDADSSVKEDWKYVAMVIDRIFLWLF 508


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  302 bits (773), Expect = 5e-82
 Identities = 157/452 (34%), Positives = 242/452 (53%), Gaps = 33/452 (7%)

Query: 32  KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYL 91
           +LF  LF++Y   +RPV +    + V  EV ++Q+ ++DE NQ++   LW+R  W D  L
Sbjct: 36  RLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKL 95

Query: 92  RWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITR 151
           RWDP  Y G++ +R+P+  +W+PDIVLYN A         T  +L+++G + W  PAI +
Sbjct: 96  RWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFK 155

Query: 152 SSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARR 211
           SSC +D+  FPFD Q+C L FGSWT+   ++D+   G+   + DF EN EW ++     +
Sbjct: 156 SSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYK 215

Query: 212 RVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLG 271
             + Y CC E Y D+T++  +RR    Y  NL++PC+ IS L  L F+LP+D GEKV+L 
Sbjct: 216 HDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLC 275

Query: 272 VTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVR 330
           ++VLL+LTVF L++ E++P     VPL+G+Y + TM  VT S  +T+ ++N+HY  P+  
Sbjct: 276 ISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTH 335

Query: 331 PVPAWARALLLGHLARGLCVR-----ERGE-----PCGQSRPPELSPSPQSPEGGAGPPA 380
            +P W + + L  L + L +R      RG      P G +R P         E       
Sbjct: 336 TMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKEC 395

Query: 381 GPCHEPRCLCRQEALLHH----------------------VATIANTFRSHRAAQRCHED 418
             CH+   L   +  L H                      V  IA   +SH   +   +D
Sbjct: 396 FHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDD 455

Query: 419 WKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450
           WK +A V+DR FL +F  + +  +  + +Q L
Sbjct: 456 WKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPL 487


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  294 bits (753), Expect = 1e-79
 Identities = 154/445 (34%), Positives = 248/445 (55%), Gaps = 6/445 (1%)

Query: 12  LLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDE 71
           LLLLF L +  L        +L   LF +Y+S +RPV D  Q + VT+ + L Q+I++DE
Sbjct: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65

Query: 72  RNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSAS 131
            NQ++T  + ++Q+W D  L+W+P+ YGG+  I IPS  +WRPD+VLYN AD        
Sbjct: 66  VNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF 125

Query: 132 TNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAA 191
           T V+L++ G + W  PAI +S C + V  FPFD Q+C +  G+WT+ G  + + P     
Sbjct: 126 TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP 185

Query: 192 SLADFVENVEWRVLGMPARRRVLTYGCCSE-PYPDVTFTLLLRRRAAAYVCNLLLPCVLI 250
            L++F+E+ EW +      +  +TY CC + PY D+T+  +++R    ++ N+++PC+L 
Sbjct: 186 DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLF 245

Query: 251 SLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAES-VPLIGKYYMATMTMV 309
           S L  L F+LP DSGEK++L ++VLL+LTVF L++ E +P   S VPLIGKY + TM  V
Sbjct: 246 SFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFV 305

Query: 310 TFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSP 369
             S  +T++++N H+  PS   +P W R + +  +   +       P  + +  ++    
Sbjct: 306 IASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTED 365

Query: 370 ---QSPEGGAGPPAGPCHEPRCLCRQ-EALLHHVATIANTFRSHRAAQRCHEDWKRLARV 425
                  G  GPP    H P     + ++ +  +  IA T +S + +     +WK +A V
Sbjct: 366 IDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMV 425

Query: 426 MDRFFLAIFFSMALVMSLLVLVQAL 450
           MD   L +F  + ++ +L V    L
Sbjct: 426 MDHILLGVFMLVCIIGTLAVFAGRL 450


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  289 bits (740), Expect = 3e-78
 Identities = 170/469 (36%), Positives = 259/469 (55%), Gaps = 44/469 (9%)

Query: 13  LLLFLLPAECLGAEGRLAL---KLFRDLF--ANYTSALRPVADTDQTLNVTLEVTLSQII 67
           L+LF L A C     R+A    KL  DL     Y + +RP   + Q +++ L+++L+Q+I
Sbjct: 7   LVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLI 66

Query: 68  DMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPP 127
            ++ER Q++T  +W++QEWTD  L W+ + Y G++ +RIP+  +W PDIVLYN AD    
Sbjct: 67  SVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYE 126

Query: 128 GSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPR 187
            S  TN+++R +G+V W  PAI +S+C+++V  FPFD Q+C L F SWT+   ++D+   
Sbjct: 127 VSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLM 186

Query: 188 GAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPC 247
              AS+ DF  + EW ++ +P RR V         Y DVT+  +++R+   Y  NL++PC
Sbjct: 187 TPTASMDDFTPSGEWDIVALPGRRTVNPQ---DPSYVDVTYDFIIKRKPLFYTINLIIPC 243

Query: 248 VLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMATM 306
           VL +LLA L F+LP+D GEK++L ++VLLALT F LL+++ +PP    VPLIGKY M TM
Sbjct: 244 VLTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTM 303

Query: 307 TMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRP---- 362
            +VTFS   ++ ++N+H+  PS   +  W +   L  L   L ++  G     +R     
Sbjct: 304 VLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPS 363

Query: 363 ------PELSPSPQSPEGGAG--------------PPAG--PCHEPRCLC-------RQE 393
                 PE + +  SP    G               PAG  P   PR          RQ+
Sbjct: 364 KSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQD 423

Query: 394 A--LLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALV 440
               L  V+ IA   ++    Q   EDWK +A V+DR FL +F  + ++
Sbjct: 424 VQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVL 472


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  285 bits (729), Expect = 6e-77
 Identities = 136/321 (42%), Positives = 201/321 (62%), Gaps = 1/321 (0%)

Query: 32  KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYL 91
           +L + LF+ Y    RPVA+    + V   ++++Q+ID+DE+NQ++T  +W++QEW D  L
Sbjct: 39  RLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKL 98

Query: 92  RWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITR 151
           RWDP  Y  + +IRIPS L+WRPDIVLYN AD     +  T   L HDG V+W  PAI +
Sbjct: 99  RWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYK 158

Query: 152 SSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARR 211
           SSC +DV  FPFD Q+C + FGSWT+   ++D+    +     DF E+ EW ++      
Sbjct: 159 SSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTY 218

Query: 212 RVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLG 271
               Y CC+E YPD+T+  ++RR    Y  NL++PC+LIS L  L F+LP++ GEK++L 
Sbjct: 219 NTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLC 278

Query: 272 VTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVR 330
           ++VLL+LTVF LL+ E +P    V PLIG+Y + TM  VT S  +T+ ++N+H+  P   
Sbjct: 279 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTH 338

Query: 331 PVPAWARALLLGHLARGLCVR 351
            +P W R + L  + R L ++
Sbjct: 339 TMPTWVRRVFLDIVPRLLLMK 359



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 6/92 (6%)

Query: 352 ERGEPCG---QSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRS 408
           ++  PC    +  P  +SPS          P  P H P       A+   V  IA+  ++
Sbjct: 524 DQPSPCKCTCKKEPSSVSPSATVKTRSTKAP--PPHLPLSPALTRAV-EGVQYIADHLKA 580

Query: 409 HRAAQRCHEDWKRLARVMDRFFLAIFFSMALV 440
                   EDWK +A V+DR FL +F  + L+
Sbjct: 581 EDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLL 612


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  283 bits (724), Expect = 2e-76
 Identities = 154/434 (35%), Positives = 241/434 (55%), Gaps = 31/434 (7%)

Query: 33  LFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLR 92
           L R LF  Y   +RPV  ++ T+ V   + +SQ++D+DE+NQ++T  +W++QEWTD  LR
Sbjct: 32  LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLR 91

Query: 93  WDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRS 152
           W+P+ YGG+ +I++PS  +W PDIVL+  AD +  GS  T V+++ +G V W  PA  +S
Sbjct: 92  WNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKS 151

Query: 153 SCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVL---GMPA 209
           SC +DV  FPFD Q+C + FGSWT+ G  +D+          DF +N EW +L   GM  
Sbjct: 152 SCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKG 211

Query: 210 RRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVS 269
            RR   Y      YP +T++ +LRR    Y   L++PC+ +S L  L F+LP+D GEK+S
Sbjct: 212 NRRDGVYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLS 266

Query: 270 LGVTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPS 328
           L  +VL++LTVF L++ E +P +  V PLIG+Y +  M  VT S  +T+ ++N+H+   S
Sbjct: 267 LSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS 326

Query: 329 V-RPVPAWARALLLGHLARGLCV-----------RERGEPCGQSRPPELSPSPQSPEGGA 376
              P+  W + L L  L + LC+           +E  +P  + +  E     Q  +G  
Sbjct: 327 TYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDG-- 384

Query: 377 GPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFS 436
                   E   +   E     +  I+   +      +  +DWK +A+V+DR FL +F  
Sbjct: 385 --------EKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLI 436

Query: 437 MALVMSLLVLVQAL 450
           +++  S+L+   AL
Sbjct: 437 VSVTGSVLIFTPAL 450


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  281 bits (719), Expect = 9e-76
 Identities = 152/420 (36%), Positives = 234/420 (55%), Gaps = 20/420 (4%)

Query: 33  LFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLR 92
           L +DLF +Y   +RPV   +  + +   + +SQ++D+DE+NQ++T  +W++QEW D  LR
Sbjct: 50  LLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLR 109

Query: 93  WDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRS 152
           W+P+ YGG+  IR+PS  VW PDIVL++ AD +  G+ ST  V+R++G V W  PA  +S
Sbjct: 110 WNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGT-STKTVIRYNGTVTWTPPANYKS 168

Query: 153 SCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRR 212
           SC +DV  FPFD Q+C + FGSWT+ G Q+D+          DF +N EW ++     + 
Sbjct: 169 SCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKG 228

Query: 213 VLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGV 272
             T  CC  PY  VT++ +++R    Y   L++PC+ +S L  L F+LP++ GEK+ L  
Sbjct: 229 NRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCT 286

Query: 273 TVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRP 331
           +VL++LTVF L++ E +P +  V PLIG+Y + TM  VT S  +T+  +N+H+   S   
Sbjct: 287 SVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHN 346

Query: 332 VPA-WARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLC 390
             A   R + L  L + LC+R        S         +  E G+GP +          
Sbjct: 347 AMAPLVRKIFLHTLPKLLCMR--------SHVDRYFTQKEETESGSGPKSS-------RN 391

Query: 391 RQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450
             EA L  +  I          +   EDWK +A+V+DR FL  F  +++V SL + V  +
Sbjct: 392 TLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVI 451


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  280 bits (717), Expect = 1e-75
 Identities = 154/470 (32%), Positives = 248/470 (52%), Gaps = 31/470 (6%)

Query: 12  LLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDE 71
           LLLLF L +  L        +L   LF +Y+S +RPV D  Q + VT+ + L Q+I++DE
Sbjct: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65

Query: 72  RNQVLTLYLWIRQ-------------------------EWTDAYLRWDPNAYGGLDAIRI 106
            NQ++T  + ++Q                         +W D  L+W+P+ YGG+  I I
Sbjct: 66  VNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHI 125

Query: 107 PSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQ 166
           PS  +WRPD+VLYN AD        T V+L++ G + W  PAI +S C + V  FPFD Q
Sbjct: 126 PSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQ 185

Query: 167 HCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSE-PYPD 225
           +C +  G+WT+ G  + + P      L++F+E+ EW +      +  +TY CC + PY D
Sbjct: 186 NCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLD 245

Query: 226 VTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLL 285
           +T+  +++R    ++ N+++PC+L S L  L F+LP DSGEK++L ++VLL+LTVF L++
Sbjct: 246 ITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVI 305

Query: 286 AESMPPAES-VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHL 344
            E +P   S VPLIGKY + TM  V  S  +T++++N H+  PS   +P W R + +  +
Sbjct: 306 VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTI 365

Query: 345 ARGLCVRERGEPCGQSRPPELSPSP---QSPEGGAGPPAGPCHEPRCLCRQ-EALLHHVA 400
              +       P  + +  ++           G  GPP    H P     + ++ +  + 
Sbjct: 366 PNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIK 425

Query: 401 TIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450
            IA T +S + +     +WK +A VMD   L +F  + ++ +L V    L
Sbjct: 426 YIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRL 475


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  279 bits (714), Expect = 3e-75
 Identities = 171/479 (35%), Positives = 256/479 (53%), Gaps = 42/479 (8%)

Query: 10  LGLLLLFLLPAECLGAEGR-LALKLFRDLF--ANYTSALRPVADTDQTLNVTLEVTLSQI 66
           + LLL F L   C G  G     +L   L   + Y   +RP  +  + + V L V+L+Q+
Sbjct: 8   VALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQL 67

Query: 67  IDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQP 126
           I + ER Q++T  +W+ QEW D  L W P  +  +  +R+PS  +W PD+VLYN AD   
Sbjct: 68  ISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMY 127

Query: 127 PGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRP 186
             S  +N V+ +DG++ W  PAI +S+C+++V  FPFD Q+C + F SWT+   ++D+  
Sbjct: 128 EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL 187

Query: 187 RGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLP 246
           +   ASL DF  + EW ++ +P RR           Y D+T+  ++RR+   Y  NL++P
Sbjct: 188 KSEVASLDDFTPSGEWDIVALPGRR---NENPDDSTYVDITYDFIIRRKPLFYTINLIIP 244

Query: 247 CVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMAT 305
           CVLI+ LA L F+LP+D GEK++L ++VLLALTVF LL+++ +PP    VPL+GKY M T
Sbjct: 245 CVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFT 304

Query: 306 MTMVTFSTALTILIMNLHYCGPSVRPVPAWAR--------ALLLGHLARGLCVRERGEPC 357
           M +VTFS   ++ ++N+H+  P+   +  W +        ALL     R  C R+R    
Sbjct: 305 MVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLR 364

Query: 358 GQSRPPE------LSPSP-----------QSPEGGAG-------PPAGP--CHEPRCLCR 391
            + R  E         +P            S +G AG       P AGP    EP C C 
Sbjct: 365 RRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEP-CGCG 423

Query: 392 QEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450
               +  V  IA+  RS    Q   EDWK +A V+DR FL IF  + +  ++ + +Q L
Sbjct: 424 LREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPL 482


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  242 bits (618), Expect = 4e-64
 Identities = 153/473 (32%), Positives = 239/473 (50%), Gaps = 56/473 (11%)

Query: 25  AEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQ 84
           AEGRL  KLF    + Y S++RP  +    + V++ + L+Q+I ++E+++ ++  +++  
Sbjct: 26  AEGRLREKLF----SGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDL 81

Query: 85  EWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRW 144
           EWTD  L WDP  + G+D++RI +  VW PD+VL N  D     +   +VV+  DG+VRW
Sbjct: 82  EWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRW 141

Query: 145 DAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVR----PRGAA-----ASLAD 195
             P I RSSC + V  FPFD Q+C + F S+++   ++ ++    P G            
Sbjct: 142 QPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGT 201

Query: 196 FVENVEWRVLGMPARRRVL---TYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISL 252
           F+EN +W ++  P+R         G       +V F L++RR+   Y+ N++ PC+LI+L
Sbjct: 202 FIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITL 261

Query: 253 LAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMATMTMVTF 311
           LA   F+LP D+GEK+ L +  LL LTVF LLLA+ +P    SVP+I KY M TM +VTF
Sbjct: 262 LAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTF 321

Query: 312 STALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCV-RERGEPCGQSRPPELSPSPQ 370
           S  L+++++NLH+  P    +P W R + +  L   L + R + E      PP  S    
Sbjct: 322 SVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCS---- 377

Query: 371 SPEGGAG----------PPA------------------------GPCHEPRCLCRQEALL 396
           SP  G G          PP+                        GP      L     ++
Sbjct: 378 SPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVV 437

Query: 397 HHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449
             ++ IA   +         EDW+ +A V+DR FL  F     V +L++ + A
Sbjct: 438 SSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDA 490


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  232 bits (592), Expect = 5e-61
 Identities = 141/375 (37%), Positives = 199/375 (53%), Gaps = 49/375 (13%)

Query: 122 ADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQ 181
           AD +   +  TNV++   G  ++  P I +SSC +DV  FPFD QHC L FGSW++GG  
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87

Query: 182 LDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVC 241
           LD++ +   A ++ ++ N EW ++G+P +R    Y CC EPYPDVTFT+ +RRR   Y  
Sbjct: 88  LDLQMQ--EADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGL 145

Query: 242 NLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGK 300
           NLL+PCVLIS LA L F LPADSGEK+SLG+TVLL+LTVF LL+AE MP  ++SVPLI +
Sbjct: 146 NLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQ 205

Query: 301 YYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGE----P 356
           Y+ +TM +V  S  +T++++  H+  P    +P W R +LL   A  L ++  GE    P
Sbjct: 206 YFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP 265

Query: 357 CGQSRPPELSPSPQSPEGGAGPPAG------------------PCHEPRCLC-------- 390
             Q +    S +       A PPA                   P  +   +C        
Sbjct: 266 ACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT 325

Query: 391 RQEALLH----------------HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIF 434
             E LLH                 V  IAN FR    ++    +WK  A V+DR  L  F
Sbjct: 326 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 385

Query: 435 FSMALVMSLLVLVQA 449
               ++ ++ +L+ A
Sbjct: 386 SVFTIICTIGILMSA 400


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  232 bits (592), Expect = 5e-61
 Identities = 140/377 (37%), Positives = 206/377 (54%), Gaps = 26/377 (6%)

Query: 8   LSLGLLL-LFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQI 66
           L+LGLL  L +  +  L  E RL   LF++    Y   LRPVA  +++++V L +TLS +
Sbjct: 6   LTLGLLAALAVCGSWGLNEEERLIRHLFQE--KGYNKELRPVAHKEESVDVALALTLSNL 63

Query: 67  IDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQP 126
           I + E  + LT  +WI   WTD  L+W+   +G +  +R+P  +VW P+IVL N  D   
Sbjct: 64  ISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSF 123

Query: 127 PGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRP 186
             S S NV++ H G V W  PAI RSSC + V  FPFD Q+C L F S  +   ++ +  
Sbjct: 124 QISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSL 183

Query: 187 RGAAAS---------LAD---FVENVEWRVLGMPARRRVLTYGCCSEP-YPDVTFTLLLR 233
           +  A           + D   F EN EW ++  PAR  V        P   D+TF L++R
Sbjct: 184 KQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIR 243

Query: 234 RRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE 293
           R+   Y+ N+L+PCVLIS +  L F+LPADSGEK S+ ++VLLA +VF LL+++ +P   
Sbjct: 244 RKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATS 303

Query: 294 -SVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRE 352
            ++PLIGK+ +  M +VT    + ++++N+H+  PS   +    + L L  L        
Sbjct: 304 MAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLP------- 356

Query: 353 RGEPCGQSRPPELSPSP 369
             E    SRP E  PSP
Sbjct: 357 --ELLHMSRPAEDGPSP 371


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  231 bits (589), Expect = 1e-60
 Identities = 145/470 (30%), Positives = 234/470 (49%), Gaps = 43/470 (9%)

Query: 13  LLLFLLPAECLGAEGRLA--------LKLFRDLFANYTSALRPVADTDQTLNVTLEVTLS 64
           LL  LLP      E R +        L+L   L  NY   +RPV D  +   V+++V + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 65  QIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADA 124
            I+++DE+NQVLT Y+W RQ WTD +L+W+P  +  +  + IP+  +W PDI++    D 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134

Query: 125 QPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDV 184
               +    V +RH G V+   P    ++C +D+  FPFD Q+C LTF SW H    +++
Sbjct: 135 GKSPNI-PYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 185 R----PRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV 240
                P    +  + F+   EW +LG+    R  +    S  Y ++ F +++RRR   YV
Sbjct: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYV 252

Query: 241 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIG 299
            +LLLP + + ++  + F+LP +SGE+VS  +T+LL  +VF +++++++P  A   PLIG
Sbjct: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312

Query: 300 KYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQ 359
            Y++  M ++  S A TI I+ L +     +PVPAW R L+L  +A  LC+RE+      
Sbjct: 313 VYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQST---S 369

Query: 360 SRPPELSPS------------------PQ----SPEGGAGPPAGPCHEPRCLCRQEALLH 397
            RPP  S +                  PQ    SP     PP  P      +C    LL 
Sbjct: 370 QRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVC---GLLQ 426

Query: 398 HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLV 447
            +++I          +    DW R+  V+D+    I+    L  S+ +++
Sbjct: 427 ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 476


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  229 bits (584), Expect = 4e-60
 Identities = 138/444 (31%), Positives = 226/444 (50%), Gaps = 35/444 (7%)

Query: 31  LKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAY 90
           L+L   L  NY   +RPV D  +   V+++V +  I+++DE+NQVLT Y+W RQ WTD +
Sbjct: 20  LRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEF 79

Query: 91  LRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAIT 150
           L+W+P  +  +  + IP+  +W PDI++    D     +    V +RH G V+   P   
Sbjct: 80  LQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNI-PYVYIRHQGEVQNYKPLQV 138

Query: 151 RSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVR----PRGAAASLADFVENVEWRVLG 206
            ++C +D+  FPFD Q+C LTF SW H    +++     P    +  + F+   EW +LG
Sbjct: 139 VTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLG 198

Query: 207 MPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGE 266
           +    R  +    S  Y ++ F +++RRR   YV +LLLP + + ++  + F+LP +SGE
Sbjct: 199 VLPYFREFSME-SSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 257

Query: 267 KVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIMNLHYC 325
           +VS  +T+LL  +VF +++++++P  A   PLIG Y++  M ++  S A TI I+ L + 
Sbjct: 258 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHK 317

Query: 326 GPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPS----------------- 368
               +PVPAW R L+L  +A  LC+RE+       RPP  S +                 
Sbjct: 318 QDLQQPVPAWLRHLVLERIAWLLCLREQST---SQRPPATSQATKTDDCSAMGNHCSHMG 374

Query: 369 -PQ----SPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLA 423
            PQ    SP     PP  P      +C    LL  +++I          +    DW R+ 
Sbjct: 375 GPQDFEKSPRDRCSPPPPPREASLAVC---GLLQELSSIRQFLEKRDEIREVARDWLRVG 431

Query: 424 RVMDRFFLAIFFSMALVMSLLVLV 447
            V+D+    I+    L  S+ +++
Sbjct: 432 SVLDKLLFHIYLLAVLAYSITLVM 455


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  222 bits (565), Expect = 6e-58
 Identities = 129/347 (37%), Positives = 190/347 (54%), Gaps = 12/347 (3%)

Query: 7   HLSLGLLLLFLLPAECLGAEGR-LALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQ 65
           H   G LLL LL A CLGA+GR    +L  DL  NY   LRP       +NV+L++TL+ 
Sbjct: 2   HGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTN 61

Query: 66  IIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQ 125
           +I ++ER + LT  +WI  +W D  LRWDP  Y GL  +R+PS++VWRPDIVL N  D  
Sbjct: 62  LISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGV 121

Query: 126 PPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVR 185
              +   NV++  DG + W  PAI RS+C + V  FPFD Q+C L F S T+  +++D++
Sbjct: 122 FEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQ 181

Query: 186 PRGAAASLAD--------FVENVEWRVLGMPARRRVLTYGCCSEP-YPDVTFTLLLRRRA 236
                    +        F EN EW +   PA+  +       E  +  V F LL++R+ 
Sbjct: 182 LSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKP 241

Query: 237 AAYVCNLLLPCVLISLLAPLAFHLPADS-GEKVSLGVTVLLALTVFQLLLAESMP-PAES 294
             YV N++ PCVLIS +A L   LPA + G+K ++ + VLLA TVF  L+A+ +P  +++
Sbjct: 242 LFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQA 301

Query: 295 VPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLL 341
           VPLI KY    + +        ++++N+    P    +    R + L
Sbjct: 302 VPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFL 348


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  217 bits (553), Expect = 2e-56
 Identities = 146/502 (29%), Positives = 235/502 (46%), Gaps = 75/502 (14%)

Query: 13  LLLFLLPAECLGAEGRLA--------LKLFRDLFANYTSALRPVADTDQTLNVTLEVTLS 64
           LL  LLP      E R +        L+L   L  NY   +RPV D  +   V+++V + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 65  QIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADA 124
            I+++DE+NQVLT Y+W RQ WTD +L+W+P  +  +  + IP+  +W PDI++    D 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134

Query: 125 QPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDV 184
               +    V +RH G V+   P    ++C +D+  FPFD Q+C LTF SW H    +++
Sbjct: 135 GKSPNIPY-VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 185 R----PRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYV 240
                P    +  + F+   EW +LG+    R  +    S  Y ++ F +++RRR   YV
Sbjct: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMES-SNYYAEMKFYVVIRRRPLFYV 252

Query: 241 CNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPP-AESVPLIG 299
            +LLLP + + ++  + F+LP +SGE+VS  +T+LL  +VF +++++++P  A   PLIG
Sbjct: 253 VSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIG 312

Query: 300 K--------------------------------YYMATMTMVTFSTALTILIMNLHYCGP 327
           K                                Y++  M ++  S A TI I+ L +   
Sbjct: 313 KAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQD 372

Query: 328 SVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPS------------------P 369
             +PVPAW R L+L  +A  LC+RE+       RPP  S +                  P
Sbjct: 373 LQQPVPAWLRHLVLERIAWLLCLREQST---SQRPPATSQATKTDDCSAMGNHCSHMGGP 429

Query: 370 Q----SPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARV 425
           Q    SP     PP  P      +C    LL  +++I          +    DW R+  V
Sbjct: 430 QDFEKSPRDRCSPPPPPREASLAVC---GLLQELSSIRQFLEKRDEIREVARDWLRVGSV 486

Query: 426 MDRFFLAIFFSMALVMSLLVLV 447
           +D+    I+    L  S+ +++
Sbjct: 487 LDKLLFHIYLLAVLAYSITLVM 508


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  211 bits (536), Expect = 1e-54
 Identities = 133/375 (35%), Positives = 203/375 (54%), Gaps = 24/375 (6%)

Query: 10  LGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDM 69
           LG+LLL  L    +G    L  +L+  LF NY    RPV + + T+ ++L+VTL+ +I +
Sbjct: 6   LGVLLLLGLLGRGVGKNEEL--RLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISL 63

Query: 70  DERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGS 129
           +E+ + LT  +WI  +W D  L +  + +GG++ +R+PS LVW P+IVL N  D Q   +
Sbjct: 64  NEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVA 123

Query: 130 ASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLD----VR 185
              NV++   G+V W  PAI RS C V+V  FPFD Q+C L F S T+   +++    V 
Sbjct: 124 YDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVD 183

Query: 186 PRGAAASLAD-----FVENVEWRVLGMPARRRVLTYGCCSEP-YPDVTFTLLLRRRAAAY 239
             G   +  D     + EN EW +   P   R    G    P   DV ++L++RR+   Y
Sbjct: 184 NDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFY 243

Query: 240 VCNLLLPCVLISLLAPLAFHLPADSG-EKVSLGVTVLLALTVFQLLLAESMPPAE-SVPL 297
           V N+++PCVLIS L  LA+ LPA +G +K ++ + VLLA TVF  L+A+ +P    SVPL
Sbjct: 244 VINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPL 303

Query: 298 IGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPC 357
           +G++ +  M + T      ++++N+    P+   +    R +LL  L R L     G P 
Sbjct: 304 LGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLL-----GSP- 357

Query: 358 GQSRPPELSPSPQSP 372
               PP  +P   SP
Sbjct: 358 ----PPPEAPRAASP 368


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  178 bits (452), Expect = 8e-45
 Identities = 112/306 (36%), Positives = 157/306 (51%), Gaps = 47/306 (15%)

Query: 191 ASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLI 250
           A ++ ++ N EW ++G+P +R    Y CC EPYPDVTFT+ +RRR   Y  NLL+PCVLI
Sbjct: 4   ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 63

Query: 251 SLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMV 309
           S LA L F LPADSGEK+SLG+TVLL+LTVF LL+AE MP  ++SVPLI +Y+ +TM +V
Sbjct: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123

Query: 310 TFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGE----PCGQSRPPEL 365
             S  +T++++  H+  P    +P W R +LL   A  L ++  GE    P  Q +    
Sbjct: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183

Query: 366 SPSPQSPEGGAGPPAG------------------PCHEPRCLC--------RQEALLH-- 397
           S +       A PPA                   P  +   +C          E LLH  
Sbjct: 184 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGG 243

Query: 398 --------------HVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSL 443
                          V  IAN FR    ++    +WK  A V+DR  L  F    ++ ++
Sbjct: 244 QPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTI 303

Query: 444 LVLVQA 449
            +L+ A
Sbjct: 304 GILMSA 309


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  168 bits (425), Expect = 1e-41
 Identities = 115/412 (27%), Positives = 190/412 (46%), Gaps = 24/412 (5%)

Query: 46  RPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIR 105
           RPV +      V +   +S I+D++E+  +L+ +LW+   W + ++ W+P    G+  + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 106 IPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDA 165
           + +  +W PDI +    D        T  V  ++G +R+  P    S C +D+  FPFD 
Sbjct: 130 MAAKNLWLPDIFIIELMDVDKTPKGLTAYV-SNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188

Query: 166 QHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENV-----EWRVLGMPARRRVLTYGCCS 220
           Q+C LTF S+ +    + +        + D   N+     EW +LG+      L+ G   
Sbjct: 189 QNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRG--G 246

Query: 221 EPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTV 280
             Y  + F + +RRR + YV NLL+P   +  +  L+F+LP  SG +V   +T+LL   V
Sbjct: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306

Query: 281 FQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMN-LHYCGPSVRPVPAWARAL 339
           F L++++ + P    PLIG Y+   ++++  S   TI I + LH       P+P W  +L
Sbjct: 307 FLLMMSDLL-PTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSL 365

Query: 340 LLGHLARGLC--VRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLH 397
           LL   + G C     + E  G    P   P  + PE  AG   GP          EA L 
Sbjct: 366 LLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPA---------EAELT 416

Query: 398 HVATIANTFRSHRA-AQRCHEDWKRLARVMDR--FFLAIFFSMALVMSLLVL 446
             +      R H A  Q   E W + +  MD   F L + F  + +++++ L
Sbjct: 417 GGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICL 468


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  155 bits (391), Expect = 9e-38
 Identities = 97/347 (27%), Positives = 163/347 (46%), Gaps = 12/347 (3%)

Query: 44  ALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDA 103
           A RP  +      V +  TLS I+ +D + Q+LT +LW+   W + ++ W+P    G++ 
Sbjct: 53  AFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINK 112

Query: 104 IRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPF 163
           + + +  +W PDI +    D     S  T   +  +G +++D P    S C +D+  FPF
Sbjct: 113 LTVLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPF 171

Query: 164 DAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENV-----EWRVLGMPARRRVLTYGC 218
           D Q+C  TF S+ +    + +        + D    V     EW +LG+      ++ G 
Sbjct: 172 DQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMG- 230

Query: 219 CSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLAL 278
            +  Y  + F + +RRR + Y+ NLL+P   +  +  L+F+LPA+S  +    +T+LL  
Sbjct: 231 -NNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGY 289

Query: 279 TVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNL-HYCGPSVRPVPAWAR 337
            VF LL+   + PA   PLI  Y+   ++++  S   T+ I  L H       P+P W  
Sbjct: 290 NVF-LLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLH 348

Query: 338 ALLLGHLARGLCVRERGEPCGQSRPPELS--PSPQSPEGGAGPPAGP 382
           +LLL   + G C     +   +     L+  P P+ P   AG   GP
Sbjct: 349 SLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGP 395


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  137 bits (344), Expect = 3e-32
 Identities = 78/293 (26%), Positives = 145/293 (49%), Gaps = 8/293 (2%)

Query: 33  LFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLR 92
           L + L   Y   +RPV +  +   V L++ +  I+D+D  NQ+L   +W ++ W D +L 
Sbjct: 35  LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94

Query: 93  WDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRS 152
           W+ + +  +  I +P S +W PDI++    D +        V +   G +    P    S
Sbjct: 95  WNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDL-PYVYVNSSGTIENYKPIQVVS 153

Query: 153 SCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDV----RPRGAAASLADFVENVEWRVLGMP 208
           +C ++  AFPFD Q+C LTF S  H    +D+     P         F+ + EW +L + 
Sbjct: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVS 213

Query: 209 ARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKV 268
           +   +L     +  +  + F +++RR    YV +LL+P + + L+   +F+LP +   ++
Sbjct: 214 STYSILQ--SSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARI 271

Query: 269 SLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIM 320
               +VL+  TVF++ ++  +P    S PLIG ++   M  +  S A +I+++
Sbjct: 272 VFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324


>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 97/408 (23%), Positives = 164/408 (40%), Gaps = 60/408 (14%)

Query: 70  DERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPG- 128
           D   Q++T +LW+          W+P+  GG+    + +  +W  D+ +    D  P G 
Sbjct: 23  DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGL 74

Query: 129 SASTNVVLRHDGAVR---WDA-----PAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGH 180
            AS ++V      +    W A     P+I+ S  R + +              +W     
Sbjct: 75  MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQ---VTRAWRRMSR 131

Query: 181 QLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRA--AA 238
              +  R        F    EW +LG+  ++R +     +  Y    F + +RRR   + 
Sbjct: 132 SFQIHHR------TSFRTRREWVLLGI--QKRTIKVTVATNQYEQAIFHVAIRRRCRPSP 183

Query: 239 YVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAES---V 295
           YV N L+P  ++  +  L+F+LP +SG      +TVLL  +VF L++ + +P   +    
Sbjct: 184 YVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHA 243

Query: 296 PLI----------GKYYMATMTMVTFSTALTILIMN-LHYCGPSVRPVPAWARALLLGHL 344
            L+          G Y+   ++++  S   TI I + LH       P+P W  +LLL   
Sbjct: 244 SLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCT 303

Query: 345 ARGLC---VRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVAT 401
            +G C     ++G   G    P   P  + PE  AG   GP          EA L   + 
Sbjct: 304 GQGRCCPTAPQKGNK-GPGLTPTHLPGVKEPEVSAGQMPGP---------GEAELTGGSE 353

Query: 402 IANTFRSHRA-AQRCHEDWKRLARVMDR--FFLAIFFSMALVMSLLVL 446
                R H A  Q   E W + +  MD   F L + F  + +++++ L
Sbjct: 354 WTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICL 401


>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 70/279 (25%), Positives = 122/279 (43%), Gaps = 17/279 (6%)

Query: 57  VTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAI-----RIPSSLV 111
           V + + ++ I  + E N   TL ++ +Q W D  L     AY G+        R+   L 
Sbjct: 63  VGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL-----AYSGIPLNLTLDNRVADQL- 116

Query: 112 WRPDIVLYNKADAQPPGSASTNVVLR--HDGAVRWDAPAITRSSCRVDVAAFPFDAQHCG 169
           W PD    N   +   G    N ++R   DG V +     T ++C +D+  +P D Q+C 
Sbjct: 117 WVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCT 176

Query: 170 LTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRV-LTYGCCSEPYPDVTF 228
           L   S+ +    ++   RG   ++   VE +E     +   R V       +  YP ++ 
Sbjct: 177 LEIESYGYTTDDIEFYWRGGDKAVTG-VERIELPQFSIVEHRLVSRNVVFATGAYPRLSL 235

Query: 229 TLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPAD-SGEKVSLGVTVLLALTVFQLLLAE 287
           +  L+R    ++    +P +LI++L+ ++F +  D S  +V+LG+T +L +T     L E
Sbjct: 236 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE 295

Query: 288 SMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCG 326
           ++P    V  I  Y M     V F   L    +N  + G
Sbjct: 296 TLPKIPYVKAIDMYLMGCFVFV-FLALLEYAFVNYIFFG 333


>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 1 precursor [Homo sapiens]
          Length = 473

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 70/279 (25%), Positives = 122/279 (43%), Gaps = 17/279 (6%)

Query: 57  VTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAI-----RIPSSLV 111
           V + + ++ I  + E N   TL ++ +Q W D  L     AY G+        R+   L 
Sbjct: 63  VGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRL-----AYSGIPLNLTLDNRVADQL- 116

Query: 112 WRPDIVLYNKADAQPPGSASTNVVLR--HDGAVRWDAPAITRSSCRVDVAAFPFDAQHCG 169
           W PD    N   +   G    N ++R   DG V +     T ++C +D+  +P D Q+C 
Sbjct: 117 WVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCT 176

Query: 170 LTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRV-LTYGCCSEPYPDVTF 228
           L   S+ +    ++   RG   ++   VE +E     +   R V       +  YP ++ 
Sbjct: 177 LEIESYGYTTDDIEFYWRGGDKAVTG-VERIELPQFSIVEHRLVSRNVVFATGAYPRLSL 235

Query: 229 TLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPAD-SGEKVSLGVTVLLALTVFQLLLAE 287
           +  L+R    ++    +P +LI++L+ ++F +  D S  +V+LG+T +L +T     L E
Sbjct: 236 SFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRE 295

Query: 288 SMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCG 326
           ++P    V  I  Y M     V F   L    +N  + G
Sbjct: 296 TLPKIPYVKAIDMYLMGCFVFV-FLALLEYAFVNYIFFG 333


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 65/275 (23%), Positives = 123/275 (44%), Gaps = 9/275 (3%)

Query: 57  VTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDI 116
           V + + ++ I  + E N   TL ++ +Q W D  L ++          R+   L W PD 
Sbjct: 62  VGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQL-WVPDT 120

Query: 117 VLYNKADAQPPGSASTNVVLR--HDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGS 174
              N   +   G    N ++R   DG V +     T ++C +D+  +P D Q+C L   S
Sbjct: 121 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 180

Query: 175 WTHGGHQLDVRPRG--AAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLL 232
           + +    ++   RG   A +    +E  ++ ++      + + +   S  YP ++ +  L
Sbjct: 181 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGS--YPRLSLSFKL 238

Query: 233 RRRAAAYVCNLLLPCVLISLLAPLAFHLPAD-SGEKVSLGVTVLLALTVFQLLLAESMPP 291
           +R    ++    +P +LI++L+ ++F +  D S  +V+LG+T +L +T     L E++P 
Sbjct: 239 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPK 298

Query: 292 AESVPLIGKYYMATMTMVTFSTALTILIMNLHYCG 326
              V  I  Y M     V F   L   ++N  + G
Sbjct: 299 IPYVKAIDMYLMGCFVFV-FMALLEYALVNYIFFG 332


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 65/275 (23%), Positives = 123/275 (44%), Gaps = 9/275 (3%)

Query: 57  VTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDI 116
           V + + ++ I  + E N   TL ++ +Q W D  L ++          R+   L W PD 
Sbjct: 62  VGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQL-WVPDT 120

Query: 117 VLYNKADAQPPGSASTNVVLR--HDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGS 174
              N   +   G    N ++R   DG V +     T ++C +D+  +P D Q+C L   S
Sbjct: 121 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 180

Query: 175 WTHGGHQLDVRPRG--AAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLL 232
           + +    ++   RG   A +    +E  ++ ++      + + +   S  YP ++ +  L
Sbjct: 181 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGS--YPRLSLSFKL 238

Query: 233 RRRAAAYVCNLLLPCVLISLLAPLAFHLPAD-SGEKVSLGVTVLLALTVFQLLLAESMPP 291
           +R    ++    +P +LI++L+ ++F +  D S  +V+LG+T +L +T     L E++P 
Sbjct: 239 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPK 298

Query: 292 AESVPLIGKYYMATMTMVTFSTALTILIMNLHYCG 326
              V  I  Y M     V F   L   ++N  + G
Sbjct: 299 IPYVKAIDMYLMGCFVFV-FMALLEYALVNYIFFG 332


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.139    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,654,931
Number of Sequences: 37866
Number of extensions: 953141
Number of successful extensions: 6685
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 6403
Number of HSP's gapped (non-prelim): 214
length of query: 450
length of database: 18,247,518
effective HSP length: 106
effective length of query: 344
effective length of database: 14,233,722
effective search space: 4896400368
effective search space used: 4896400368
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.