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Search of human proteins with 110815815
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110815815 centlein isoform 1 [Homo sapiens]
(1406 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110815815 centlein isoform 1 [Homo sapiens] 2698 0.0
gi|167555106 centlein isoform 2 [Homo sapiens] 740 0.0
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 167 5e-41
gi|71061468 centromere protein E [Homo sapiens] 165 2e-40
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 165 3e-40
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 151 5e-36
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 145 3e-34
gi|55770834 centromere protein F [Homo sapiens] 143 1e-33
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 141 5e-33
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 141 5e-33
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 141 5e-33
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 140 7e-33
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 140 7e-33
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 140 9e-33
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 140 9e-33
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 138 3e-32
gi|58530840 desmoplakin isoform I [Homo sapiens] 137 7e-32
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 136 2e-31
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 136 2e-31
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 135 3e-31
gi|156104908 myosin heavy chain 6 [Homo sapiens] 135 4e-31
gi|21735548 centrosomal protein 2 [Homo sapiens] 134 5e-31
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 134 8e-31
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 134 8e-31
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 133 1e-30
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 132 2e-30
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 131 5e-30
gi|148746195 trichohyalin [Homo sapiens] 128 3e-29
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 128 3e-29
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 126 1e-28
>gi|110815815 centlein isoform 1 [Homo sapiens]
Length = 1406
Score = 2698 bits (6993), Expect = 0.0
Identities = 1406/1406 (100%), Positives = 1406/1406 (100%)
Query: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE
Sbjct: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
Query: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ
Sbjct: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
Query: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE
Sbjct: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
Query: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI
Sbjct: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
Query: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ
Sbjct: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
Query: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM
Sbjct: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
Query: 361 DTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENA 420
DTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENA
Sbjct: 361 DTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENA 420
Query: 421 KLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANE 480
KLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANE
Sbjct: 421 KLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANE 480
Query: 481 KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIEN 540
KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIEN
Sbjct: 481 KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIEN 540
Query: 541 LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADP 600
LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADP
Sbjct: 541 LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADP 600
Query: 601 QQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAER 660
QQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAER
Sbjct: 601 QQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAER 660
Query: 661 REEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMK 720
REEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMK
Sbjct: 661 REEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMK 720
Query: 721 ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAE 780
ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAE
Sbjct: 721 ENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAE 780
Query: 781 ANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVG 840
ANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVG
Sbjct: 781 ANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVG 840
Query: 841 RHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDG 900
RHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDG
Sbjct: 841 RHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDG 900
Query: 901 KDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAV 960
KDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAV
Sbjct: 901 KDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAV 960
Query: 961 PTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLL 1020
PTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLL
Sbjct: 961 PTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLL 1020
Query: 1021 HQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQ 1080
HQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQ
Sbjct: 1021 HQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQ 1080
Query: 1081 VTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRME 1140
VTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRME
Sbjct: 1081 VTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRME 1140
Query: 1141 RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLN 1200
RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLN
Sbjct: 1141 RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLN 1200
Query: 1201 VAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSE 1260
VAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSE
Sbjct: 1201 VAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSE 1260
Query: 1261 QVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTH 1320
QVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTH
Sbjct: 1261 QVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTH 1320
Query: 1321 KAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYL 1380
KAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYL
Sbjct: 1321 KAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYL 1380
Query: 1381 LEAVLEKINEKKKLVEGYFTIMKDIR 1406
LEAVLEKINEKKKLVEGYFTIMKDIR
Sbjct: 1381 LEAVLEKINEKKKLVEGYFTIMKDIR 1406
>gi|167555106 centlein isoform 2 [Homo sapiens]
Length = 391
Score = 740 bits (1910), Expect = 0.0
Identities = 382/383 (99%), Positives = 383/383 (100%)
Query: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE
Sbjct: 1 MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGE 60
Query: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ
Sbjct: 61 EGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQ 120
Query: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE
Sbjct: 121 ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRE 180
Query: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI
Sbjct: 181 SVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI 240
Query: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ
Sbjct: 241 KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQ 300
Query: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM
Sbjct: 301 SKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM 360
Query: 361 DTQKVLRNQEDVHTAESISYQKL 383
DTQKVLRNQEDVHTAESISYQK+
Sbjct: 361 DTQKVLRNQEDVHTAESISYQKV 383
Score = 47.4 bits (111), Expect = 1e-04
Identities = 60/270 (22%), Positives = 123/270 (45%), Gaps = 25/270 (9%)
Query: 163 LEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI 222
LE + V++A + R +L++E++ L + + F+ + L+ D +Q +
Sbjct: 89 LEGISVEEAMVT----RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVV 144
Query: 223 KDTKECVQNKEE-QNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAH-LRKEKYSTDA 280
E + K E ++R V++ L+ ++ K+ E + KQE + L K K + D
Sbjct: 145 SLVVEREKQKSEAKDRKVLEILQVKDAKIQE-----FEQRESVLKQEINDLVKRKIAVD- 198
Query: 281 KIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQ 340
E+N RKE + K+ S ++ + + + K+ LV K L+E +
Sbjct: 199 -----EENAF-LRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEE------E 246
Query: 341 NSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAM 400
N + + +L+ L+ L + LR ++ A+ +++ E E ++S
Sbjct: 247 NKKLSTRCTDLLNDLEKLRKQ-EAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
Query: 401 LRQSVTNLQDQLLQKEQENAKLKEKLQESQ 430
L ++N Q +L+QK+ + ++++LQE Q
Sbjct: 306 LSLQLSNKQTELIQKDMDITLVRKELQELQ 335
Score = 46.6 bits (109), Expect = 2e-04
Identities = 70/323 (21%), Positives = 138/323 (42%), Gaps = 58/323 (17%)
Query: 1044 LAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKN 1103
L G+ E+ + + E++SL EE + + V SL K+LQ +
Sbjct: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSL---------WKRLQVTNPD 139
Query: 1104 ATN------ELTKQSSNVKTLK-FELL-AKEEHIKEMHEKISRMERDITMKRHLIEDLKF 1155
T E KQ S K K E+L K+ I+E ++ S ++++I DL
Sbjct: 140 LTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN-------DLVK 192
Query: 1156 RQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQK 1215
R+ E N + +L+KK K ++E + K + + +++ + +K
Sbjct: 193 RKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK----------N 242
Query: 1216 SKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANE 1275
+EE +K + T L++ + + A L++ ++ ++ + L+ A +
Sbjct: 243 LEEENKKLSTRCTDLLNDLEKLRKQEA--------HLRKEKYSTDAKIKTFEDNLIEARK 294
Query: 1276 KVEEFTTFVKALAKELQN----------DVHVVRRQIRELKKMKKNRDACKTSTHKAQTL 1325
+VE + AL+ +L N D+ +VR++++EL+ + K + STH AQ
Sbjct: 295 EVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYK-----QNSTHTAQQA 349
Query: 1326 -AASILNISRSDLEEILDTEDQV 1347
L + D +++L ++ V
Sbjct: 350 ELIQQLQVLNMDTQKVLRNQEDV 372
Score = 41.2 bits (95), Expect = 0.007
Identities = 43/226 (19%), Positives = 99/226 (43%), Gaps = 18/226 (7%)
Query: 938 KNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSV 997
K+AK F+++ +++ + V ++ ++ ++ S +++ ++
Sbjct: 169 KDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKEC 228
Query: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
+QN ++ L +K +E N+KL R ++KL A LRKEK K
Sbjct: 229 VQNKEEQNRLVIKNLEEENKKL-------STRCTDLLNDLEKLRKQEAHLRKEKYSTDAK 281
Query: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSM------DLEMKQLQYKLKNATNELTKQ 1111
+++ + A + +V+ + SL S D+++ ++ +L+ N L KQ
Sbjct: 282 IKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQN-LYKQ 340
Query: 1112 SSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQ 1157
+S + EL+ + + + +K+ R + D+ H E + +++
Sbjct: 341 NSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV----HTAESISYQK 382
Score = 39.7 bits (91), Expect = 0.021
Identities = 62/306 (20%), Positives = 135/306 (44%), Gaps = 58/306 (18%)
Query: 623 QELMIQKMNL-EEELDELKVHISIDKAAIQELNRCVAERRE-----EQLFRSGEDDEVKR 676
+E M+ + L EEEL LK +EL C A++ ++L + D
Sbjct: 95 EEAMVTRTQLLEEELSSLK----------EELALCQADKEFVWSLWKRLQVTNPDLTQVV 144
Query: 677 STPEKNGKEMLEQTLQKVTEL----ENRLKSFEKRSRKLKEGNKKLMK-------ENDFL 725
S + K+ E +KV E+ + +++ FE+R LK+ L+K EN FL
Sbjct: 145 SLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFL 204
Query: 726 K---SLLKQQQEDTETREKELEQIIKGS--------KDVEKENTELQVKISELETEVTSL 774
+ S L+++ +D K+ ++ ++ K++E+EN +L + ++L ++ L
Sbjct: 205 RKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKL 264
Query: 775 RRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDC-KTTMTKVKFKAA 833
R+Q A LR E ++ + A+ E ++V +Y+ ++ + +
Sbjct: 265 RKQEAH---LRKEKYSTDAKIKTFEDNLIEARKE---VEVSQSKYNALSLQLSNKQTELI 318
Query: 834 KKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQK 893
+K+ + T++ ++ + N+++ + + + +A+ Q L + ++T +
Sbjct: 319 QKDMDI----TLVRKELQELQNLYKQ---------NSTHTAQQAELIQQLQVLNMDTQKV 365
Query: 894 ISPTED 899
+ ED
Sbjct: 366 LRNQED 371
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 167 bits (424), Expect = 5e-41
Identities = 272/1269 (21%), Positives = 534/1269 (42%), Gaps = 183/1269 (14%)
Query: 51 DESDK-----IWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEG---ISVEEAMV-TR 101
DE D+ I + EE G P ++ A +P S G +R E +SVE A +
Sbjct: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP--GMKRTESRQHLSVELADAKAK 259
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
+ L +EL E+L C+ + E + KRLQ N +L +S R
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL---------SDARSARMYRD 310
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
L+ L+ K ++ + E S K+ ++D+ K V+E K+ +Q
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE---------------LKEDNQV 355
Query: 222 IKDTKECVQNKEEQNRL---VIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
+ +TK ++++ E R + LE+EN +L + D+ + + RK+ L +E +
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
+ K D + E+E + +++ +E QK + + L L
Sbjct: 416 EMAQKQSMDESLHLGWELE---------QISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 339 KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNE 398
+N + T EL + + + K+L+ +++ Q+L ++ I E E
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKE--------NQRLSKKVEI-LENEIVQE 517
Query: 399 AMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458
Q+ NL L++++ + K E L+E+ + + ++ + + V S +
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS-----SLRQ 572
Query: 459 TLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSP 518
+S ++ ++ ++++ KI +E + E S + E +H + +R+ L
Sbjct: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
Query: 519 KSSFTDSEELQKLRKAERKIENLE---KALQLKSQENDELRDAHEKRKERLQMLQTNYRA 575
+ + E ++KI NL+ + ++ QEN EL + K K+ L +++
Sbjct: 633 ELHHLEKEN----ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKN 684
Query: 576 VKEQLKQWE-EGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEE 634
+ QL+ E E S + E R + + L+ ++A + EN+E LE
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLK-----CASMKMAQLQLENKE-------LES 732
Query: 635 ELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKV 694
E ++LK + + KA+ ++ R ++ G D E +R ++ LE + +K+
Sbjct: 733 EKEQLKKGLELLKASFKKTERL-------EVSYQGLDIENQRL------QKTLENSNKKI 779
Query: 695 TELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVE 754
+LE+ L+ E ++ L +K ++E L+Q +++ ++ E+E Q+ K K +E
Sbjct: 780 QQLESELQDLEMENQTL----QKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
Query: 755 KENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMK- 813
KEN L+ + E + T+L + L EN+ L + +S R K K
Sbjct: 836 KENKRLR---QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
Query: 814 -VRSGRYDCKTTMT------KVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWE 866
V+ D KT +T K K + N + + L H ++ + E L D
Sbjct: 893 LVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK----LTHELEKIGLNKERLLHD--- 945
Query: 867 DVSESSSDS-----EAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQ 921
E S+D E++ TL + +KI+ E + + T +Q +E+
Sbjct: 946 ---EQSTDDRYKLLESKLESTLKKSLEIKEEKIAALE----ARLEESTNYNQQLRQELKT 998
Query: 922 TYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNI 981
N + + P ++ K ++ S Q+++ +
Sbjct: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERES------------------QETTREL 1040
Query: 982 ILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKL------LHQQQVSDQRFQTSRQ 1035
+ +++R+I +++ N+ LQ K+ + +K+ + N L L +Q VS Q T+ Q
Sbjct: 1041 LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100
Query: 1036 TIK-KLNLDLAGLRKEKEDLL-KKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLE 1093
T KL ++ + L + L+ + + + +SL EN V R + SL S D E
Sbjct: 1101 TQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE 1160
Query: 1094 MKQLQYK---------------LKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISR 1138
+L ++ LK+A L + +++ +LL ++ ++++ EK+ +
Sbjct: 1161 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL-EKMLK 1219
Query: 1139 MERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQR 1198
+E++ + L+E+ K + V E K E L+ L +E + +LK
Sbjct: 1220 VEQE----KMLLEN-KNHETVAAEYKKLCGEN-DRLNHTYSQLLKETEVLQTDHKNLKSL 1273
Query: 1199 LNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSR---ISETESAMAEIETAASKQLQEL 1255
LN + E+++ E + K KE+ ++ D+ T L ++ +S+ + + E Q+Q L
Sbjct: 1274 LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1333
Query: 1256 ALQSEQVLE 1264
LQ+ +LE
Sbjct: 1334 MLQNRTLLE 1342
Score = 127 bits (319), Expect = 8e-29
Identities = 188/941 (19%), Positives = 404/941 (42%), Gaps = 129/941 (13%)
Query: 524 DSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQW 583
D + ++ ++ IE L K + L + + RD H + L + +
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSA 231
Query: 584 EEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHI 643
+ G +++ + + D+ A ++ ++E +E Q ++ ++EL+++++ +
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKA---KIRRLRQELEEKTEQLLDCKQELEQMEIEL 288
Query: 644 SIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKS 703
K QE +++ R +++R DE+ + + LE + + E + ++
Sbjct: 289 ---KRLQQENMNLLSDARSARMYR----DELDALREKAVRVDKLESEVSRYKERLHDIEF 341
Query: 704 FEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVK 763
++ R +LKE N+ L++ K++L+ Q E T R +L ++ EKEN +L+ K
Sbjct: 342 YKARVEELKEDNQVLLET----KTMLEDQLEGTRARSDKLHEL-------EKENLQLKAK 390
Query: 764 ISELETEVTSLRRQVAEANALRNEN---------------------------EELINPME 796
+ ++E E R+++ E L EN EL +
Sbjct: 391 LHDMEMERDMDRKKIEE---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447
Query: 797 KS--HQ-----SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHS 849
KS H+ S+ K EM + + +TT+ V+ A+K + + + L+
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKENQRLSKK 506
Query: 850 IKVMSN--VFENLSKDGWEDVSESSSDSEAQTSQTLGT----------IIVETSQKISPT 897
++++ N V E S +++S+ +AQ +T+ T I+ + ++ ++ T
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 898 EDGKDQKESDPTE----DSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQ 953
Q+ E D + + K + ++ K K F + KK + ++ K +
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK---ELEHYKEK 623
Query: 954 KSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYK 1013
+ ++ + +N QK +N+ + E+I +L+Q+NS L+ + + ++ +K
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 1014 EVNEKL----LHQQQVSDQRFQTSR--QTIKKLNLDLAGLRKEKEDLLKKLESSSEITSL 1067
+ +L Q+ ++ + R +++K ++ +A L+ E K+LES E
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN----KELESEKEQLKK 739
Query: 1068 AEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEE 1127
E + +F + + +S + +D+E ++LQ L+N+ ++ + S ++ L+ E ++
Sbjct: 740 GLELLKASFKKTERLEVS-YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 1128 HIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSN 1187
+++E+ R+E+ + L ++ +K + K + Q + K TL E
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN--- 855
Query: 1188 KKVSIDSLKQRLNVAVKEKSQYEQMYQKSKE-ELEKKDLK----------LTL---LVSR 1233
V I +L++ KE Y++ + KE E E K+L +TL LVS
Sbjct: 856 -NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914
Query: 1234 ISETESAMAEIETAASKQLQELALQSEQVLEGAQKT---LLLANEKVEEFTTF------- 1283
+T+ ++E + +L+++ L E++L Q T L K+E
Sbjct: 915 KLKTQQMNNDLEKL-THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEE 973
Query: 1284 -VKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAAS---------ILNIS 1333
+ AL L+ + ++ +ELK +KKN +A K + + + +S S
Sbjct: 974 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1033
Query: 1334 RSDLEEILDTEDQ-VEIEKTKIDAENDKEWMLYIQKLLEGQ 1373
+ E+L +D+ +E+E+ + +K+ + K LE Q
Sbjct: 1034 QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1074
Score = 31.2 bits (69), Expect = 7.3
Identities = 38/173 (21%), Positives = 80/173 (46%), Gaps = 14/173 (8%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS-LVVEREKQKSEAKDRKVL 163
LE+ L +E++ L + E V + +K+L N L S L+ E E +++ K+ K L
Sbjct: 1214 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1273
Query: 164 EILQVKDAKIQE--FEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ ++K+++ E S LK++ L ++ + L S L+ +++++
Sbjct: 1274 ----LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL----SQLKGNLEEENRH 1325
Query: 222 IKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
+ D +Q QNR +++ E ++ L +LR+Q+ L ++
Sbjct: 1326 LLDQ---IQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 165 bits (418), Expect = 2e-40
Identities = 275/1384 (19%), Positives = 575/1384 (41%), Gaps = 204/1384 (14%)
Query: 128 SLWKRLQVTNPDLTQVVSLVVE--REKQKSEAKDRKVLEILQVKDAKIQEFEQRESV--- 182
+L K +V N DL +S VE REK+ K ++ ++ ++++ K+ ES+
Sbjct: 561 NLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDP 620
Query: 183 --LKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS---QEIKDTKECVQNKEEQNR 237
+KQ + D + E+AFLR E +L++K K+ + +++++ + Q++ E +
Sbjct: 621 KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKK 680
Query: 238 LVIKNLEEE-------------------------NKKLSTRCTDLLNDLEKLRKQEAHLR 272
+ +LE+E N +L + TDL +L K ++ LR
Sbjct: 681 KMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALR 740
Query: 273 KEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQ 332
+E +++K+ + RKE++ + + ++ + +E++ K+ + + +E+
Sbjct: 741 EEVILL-SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG 799
Query: 333 ELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLR---------NQEDVHTAE------- 376
+ ++ ++ + Q + L+MD ++ + NQE V+ ++
Sbjct: 800 KTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS 859
Query: 377 ---SISYQKLYNELHICFETTKSNEAM-----LRQSVTNLQDQLLQKEQENAKLKEKLQE 428
++ + Y + +T + E + L++ + N L E+E + EKLQ+
Sbjct: 860 SLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919
Query: 429 SQGAPLPLPQESDP----DYSAQVPHRPSLSSLETLMVSQKSEIEYL----------QEK 474
+ L QE D S Q+ S + + E L QE
Sbjct: 920 TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
Query: 475 LKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFT------DSEEL 528
+ K+SE +S N + T E + K + + + L K++ T D+E +
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 529 QKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQML---QTNYRAVKEQLKQWEE 585
++ RK I+ + Q+ E KE ++M Q R + ++LK+ +E
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 586 GSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISI 645
+ IK+ + V +L ++ QE Q +N++EE+ E+
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEM------ 1153
Query: 646 DKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFE 705
+ I E+ E + ++L T E E LE QK+ E +KS
Sbjct: 1154 -QKKINEIENLKNELKNKEL------------TLEHMETERLE-LAQKLNENYEEVKSIT 1199
Query: 706 KRSRKLKEGNKKLMKENDFLKSL---------------------LKQQQEDTETREKELE 744
K + LKE K E D L+ LK+ QE + + +
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 745 Q---IIKGSKDVEKENTELQVKISEL--ETEVTSLRRQVAEANALRNENEELINPMEKSH 799
+ I ++D+EK +T+LQ +I L E E+ ++V+E NE EL+ +
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE-LELLTEQSTTK 1318
Query: 800 QSADRAKSEMATM----KVRSGRYDCKT-TMTKVKFKAAKKNCSVGRHHTVLNHSIKVMS 854
S A+ EM + K + + + K+ T + K K+ V +H + H + ++
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV-KHDQLKEHIRETLA 1377
Query: 855 NVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTED----------GKDQK 904
+ E+ SK E S + + + ++T T IV ++ P + G ++
Sbjct: 1378 KIQESQSK------QEQSLNMKEKDNET--TKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429
Query: 905 ESDPTEDSQTQGKE-----IVQTYLNIDGKTPKDYFHDKNAK----KPTFQKKNCKMQKS 955
+ ++ ++ KE +Q L + K+ + AK + + +C +++
Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489
Query: 956 SHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEV 1015
T RV N++ +++ + I + I+ + QN + + +K + ++K+ EV
Sbjct: 1490 EETINELRV------NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543
Query: 1016 NEKLLHQQQVSDQR--FQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQ 1073
EK+ +Q + R ++ Q+I+ L+L +E ++ ++ + E +E Q
Sbjct: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ 1603
Query: 1074 VTFPRI-QVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKE- 1131
+ ++ + T ++ + + K+ Q+ A NE ++ ++ LK + ++ +++
Sbjct: 1604 IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663
Query: 1132 ----------MHEKISRMERDITMKRHLIEDLKFRQKVNLESNKS--FSEMLQNLDK--K 1177
+HE + M R +T +R + ++ KV + K + ++L+K +
Sbjct: 1664 ETENIRLTQILHENLEEM-RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
Query: 1178 VKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISET 1237
+K + + +ID L+ ++ E S ++ + S + L+ +DLK+ +
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ---EELRIA 1779
Query: 1238 ESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKE---LQND 1294
+ E + K L+ + + L QK L +N K++E +KA + L+ D
Sbjct: 1780 HMHLKEQQETIDK-LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD 1838
Query: 1295 VHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKI 1354
V+ ++++ E++++KK K Q+L S L I +L + L E+ E++
Sbjct: 1839 VNETQKKVSEMEQLKKQ--------IKDQSLTLSKLEIENLNLAQKLH-ENLEEMKSVMK 1889
Query: 1355 DAEN 1358
+ +N
Sbjct: 1890 ERDN 1893
Score = 161 bits (408), Expect = 4e-39
Identities = 286/1423 (20%), Positives = 587/1423 (41%), Gaps = 228/1423 (16%)
Query: 100 TRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKD 159
+R Q L EE+ K++LA Q++ + ++ + + D Q +V+E ++ ++
Sbjct: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ--- 845
Query: 160 RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS 219
EI+ + + Q+F+ LK E++ + + E+ +++ +++E+
Sbjct: 846 ----EIVNLSK-EAQKFDSSLGALKTELSYKTQE---LQEKTREVQERLNEMEQL----K 893
Query: 220 QEIKDTKECVQNKEEQNRLVIKNLE---EENKKLSTRCTDLLNDLEKLRKQEAHLRKEKY 276
+++++ +Q E + L+ + L+ EE K L+ DL E L+ + L+ + +
Sbjct: 894 EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
Query: 277 STDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNK------------------QTELI 318
T ++ L A + ++ Q N L ++S + Q +++
Sbjct: 954 DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMV 1013
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQA--ELIQQLQVLNMDTQKVLRNQEDVHT-- 374
D L K Q L K N Q+ LIQ+ L + V+ +E + T
Sbjct: 1014 GIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDL 1073
Query: 375 AESISYQ-KLYNELHICFETTKSNEAMLRQS----------VTNLQDQLLQKEQENAKLK 423
E+I + EL + + K + ++ Q ++ D+L + E++ +
Sbjct: 1074 KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKS 1133
Query: 424 EKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQ-EKLKIANEKL 482
++LQE Q L + +E S + +L+ + +++ +E+++ E+L++A +KL
Sbjct: 1134 QQLQEKQQQLLNVQEEM----SEMQKKINEIENLKNELKNKELTLEHMETERLELA-QKL 1188
Query: 483 SENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTD---SEELQ----KLRKAE 535
+EN K +++ + K E R + T EEL+ L++ +
Sbjct: 1189 NENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ 1248
Query: 536 RKIENLEKALQLKSQE---NDELRDAHEKRKERL------QMLQTNYRAVKEQLKQWEEG 586
I+ L +++ K+ + +L +H K +E + Q L N + V E + E
Sbjct: 1249 ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL 1308
Query: 587 SGMTEIRKIK------RADPQQLR-QEDSDAVWNELAYFKRENQELMIQKMNLEEELDEL 639
+TE K R + ++LR E E+ +E L K LE + D+L
Sbjct: 1309 ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQL 1368
Query: 640 KVHISIDKAAIQELNRCVAERREEQLFRSGEDD--------EVKRSTPEKNGKEMLEQTL 691
K HI A IQE ++ ++EQ E D E+++ P+ + +E +
Sbjct: 1369 KEHIRETLAKIQE-----SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 692 ----QKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQII 747
+++ E + +KS K L+ + L E+D LK +K+ E+EL+
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
Query: 748 KGSKDVEKENTELQVKISELETEVTSLRRQVAEAN-ALRNENEELINPME----KSHQSA 802
K+ E+ EL+V +SE ETE++++++Q+ N L+N+ +E+ E K
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543
Query: 803 DRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHH-TVLNHSIKVMSNVFENLS 861
+E+ K D + K + ++ + M V E L
Sbjct: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ 1603
Query: 862 ------KDGWEDVSESSSDSEAQTSQTLG-TIIVETSQKISPTEDGKDQKESDP--TEDS 912
K+ +++ +S+ + Q L T + ET +K+ E K+Q E+ E+
Sbjct: 1604 IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663
Query: 913 QTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI 972
+T+ + Q H+ + + K+ ++ T +V R++ K
Sbjct: 1664 ETENIRLTQ------------ILHENLEEMRSVTKERDDLRSVEET---LKVERDQLKE- 1707
Query: 973 TAQKSSSNIILLRERII-SLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQ 1031
LRE I L++Q + K + +KE++E +KL
Sbjct: 1708 ----------NLRETITRDLEKQEEL-----KIVHMHLKEHQETIDKL------------ 1740
Query: 1032 TSRQTIKKLNLDLAGLRKEKE---DLLK----KLESSSEITSLAEENSQVTFPRIQVTSL 1084
R + + +++ ++K+ E D LK K++ I + + Q T +++
Sbjct: 1741 --RGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI-- 1796
Query: 1085 SPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRME---- 1140
S D ++ +Q L+N+ +L ++ +K + +L+ ++ + E +K+S ME
Sbjct: 1797 -VSEKTD-KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK 1854
Query: 1141 ----RDITMKRHLIEDLKFRQKV--NLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDS 1194
+ +T+ + IE+L QK+ NLE KS + NL + +TL E K S+
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQE 1914
Query: 1195 LKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQE 1254
K R +E + ++ KE ++K K++ +IS+ + + + + K++QE
Sbjct: 1915 TKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQE 1974
Query: 1255 LALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDA 1314
L + Q+L ++ DV++ ++I E++++KK +A
Sbjct: 1975 LQKKELQLL--------------------------RVKEDVNMSHKKINEMEQLKKQFEA 2008
Query: 1315 CKTSTHKAQTLAASILNISRSDLEEI-LDTEDQVEIEKTKIDAENDKEWMLYIQK----- 1368
S + + LEEI + +++ E+ + K + +++ + +
Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIAR 2068
Query: 1369 -------------LLEGQLPFASYLLEAVLEKINEKKKLVEGY 1398
L +GQ +L E++ EK + K+L++ Y
Sbjct: 2069 DRQNHQVKPEKRLLSDGQ----QHLTESLREKCSRIKELLKRY 2107
Score = 148 bits (373), Expect = 4e-35
Identities = 290/1395 (20%), Positives = 575/1395 (41%), Gaps = 191/1395 (13%)
Query: 94 VEEAMVTRTQLLEE---ELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVER 150
VEE + ++Q L+E +L +++EE++ Q + +L L+ N +LT + + ER
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK--NKELT-LEHMETER 1181
Query: 151 -----------EKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDE 199
E+ KS K+RKVL+ LQ + FE L+ I ++ + E
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQ------KSFETERDHLRGYIREIEATGLQTKE 1235
Query: 200 ENAFL-------RKEFSDLEKKFKDKSQEIKDTKECVQNKEE-QNRLVIKNLEEE---NK 248
E ++ +L + +K+ +I +T++ ++ + Q + + + E+E N
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
Query: 249 KLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSL 308
K + + +N+LE L +Q T +D+ AR +E+ + + N
Sbjct: 1296 KEVSETQETMNELELLTEQS---------------TTKDSTTLAR--IEMERLRLNE-KF 1337
Query: 309 QLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQ-----QLQVLNM--- 360
Q S ++ + + K+ D KE E++ + Q H + IQ Q Q LNM
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVK--HDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 361 --DTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQ- 417
+T K++ E +S + L + +S++ M +SV +D L + ++
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEM--KSVAKEKDDLQRLQEV 1453
Query: 418 ---ENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEK 474
E+ +LKE ++E L +E + +++ L + +++EI +Q++
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 475 LKIANEKLSENISA----NKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQK 530
L+ N+KL I + F+ K I E ++ K R K S S E +
Sbjct: 1514 LEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA--KDSALQSIESKM 1571
Query: 531 LRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGS--- 587
L R E+ E+ +Q+ +E +E++ E + L+ N + + ++K+ +E
Sbjct: 1572 LELTNRLQESQEE-IQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQF 1630
Query: 588 -----------GMTEIRKIKRA-DPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEE 635
M EI +K + Q+L E+ + L EN E M ++
Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD 1690
Query: 636 LDELKVHISIDKAAIQE-LNRCVAERREEQLFRSGEDDEVKRSTPE-KNGKEMLEQ---- 689
L ++ + +++ ++E L + E+Q +E+K K +E +++
Sbjct: 1691 LRSVEETLKVERDQLKENLRETITRDLEKQ-------EELKIVHMHLKEHQETIDKLRGI 1743
Query: 690 TLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETRE----KELEQ 745
+K E+ N K E + LK + K+ +E LK+QQE + ++ ++
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803
Query: 746 IIKGSKDVEKENTELQVKISEL---ETEVTSLRRQVAEANALRNENEELINPMEKSHQSA 802
+ KD+E N +LQ KI EL E ++ +L++ V E +E E+L ++ QS
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD--QSL 1861
Query: 803 DRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSK 862
+K E+ + + ++ M V K+ ++ R L + E+L +
Sbjct: 1862 TLSKLEIENLNLAQKLHENLEEMKSVM----KERDNLRRVEETLKLE---RDQLKESLQE 1914
Query: 863 DGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKD------QKESDPTEDS---- 912
D+ E +T++ L ET K+ K QK+ D ++D
Sbjct: 1915 TKARDLE---IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK 1971
Query: 913 --QTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQ----------KSSHTAV 960
+ Q KE+ + D ++ K F+ +N MQ K H ++
Sbjct: 1972 IQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESL 2031
Query: 961 PT-------RVNREKYKNITAQKSSSNIILLRERIISLQQQNSV------LQNAKKTAEL 1007
R + K + I LRE I +Q + V L + ++
Sbjct: 2032 EEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTE 2091
Query: 1008 SVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSL 1067
S++E ++LL + D ++ + +L+LDL + +++L +++++ + L
Sbjct: 2092 SLREKCSRIKELLKRYSEMDDHYEC----LNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147
Query: 1068 AEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEE 1127
++ + F Q S+ R M K+L+Y L T +Q ++ + + + + E
Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIM----KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVE 2203
Query: 1128 HIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKT-LTEECS 1186
KE+ KI +++D + + DLK Q ++L + + ++ +KT + S
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLS 2263
Query: 1187 NKKVSIDSLKQRLNVAV---KEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAE 1243
N+K L++ LN K K+ ++ + + + ++ +++ +E E A
Sbjct: 2264 NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSAT 2323
Query: 1244 IETAASKQLQELALQSEQVLEGAQ--KTLLLANEKV-------------EEFTTFVKALA 1288
I + L+ L ++E++ + Q KT L + +V T
Sbjct: 2324 ISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKI 2383
Query: 1289 KELQNDVHVVRRQI--RELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQ 1346
+EL+N +H + +E K +K ++ T+ A+ A ++ S LE+ +T Q
Sbjct: 2384 RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAK--VHESNKCLEKTKET-IQ 2440
Query: 1347 VEIEKTKIDAENDKE 1361
V +K + A+ KE
Sbjct: 2441 VLQDKVALGAKPYKE 2455
Score = 108 bits (269), Expect = 5e-23
Identities = 245/1231 (19%), Positives = 508/1231 (41%), Gaps = 211/1231 (17%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVERE--- 151
EE V L E+E + + + L + + E + ++ K+L+ N L + + E+E
Sbjct: 1477 EELKVAHCCLKEQEETINELRVNLSEKETE-ISTIQKQLEAINDKLQNKIQEIYEKEEQF 1535
Query: 152 --KQKSEAKDRKVLEILQVKD-------------AKIQEFEQRESVLKQEINDLVKRKIA 196
KQ SE ++ KV E+ Q K+ +K+ E R ++EI ++K K
Sbjct: 1536 NIKQISEVQE-KVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEE 1594
Query: 197 VDEENAFLRKEFSDLEKKFKDKSQEIKDTKE------------------C----VQNKEE 234
+ L+ E L++ K+ ++K+++E C ++ + E
Sbjct: 1595 MKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
Query: 235 QNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNL----- 289
+L ++N+E EN +L+ + L ++ + K+ LR + + + ++NL
Sbjct: 1655 TQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT 1714
Query: 290 --IEARKEVEV-------SQSKYNALSLQLSNKQTEL--IQKDMDITLVRKELQEL--QN 336
+E ++E+++ Q + L +S K E+ +QKD++ + + Q+L Q
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
Query: 337 LYKQNSTHTAQQAELIQQLQ-VLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTK 395
+ H +Q E I +L+ +++ T K+ Q+D+ + + +K+ + K
Sbjct: 1775 ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI--------QELK 1826
Query: 396 SNEAML---RQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRP 452
+NE L ++ V Q ++ + EQ ++K++ L L + + +
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQ-------SLTLSKLEIENLNLAQKLHE 1879
Query: 453 SLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFS-------RKSIMTSAEGKH 505
+L ++++M ++ + ++E LK+ ++L E++ K + + M S E H
Sbjct: 1880 NLEEMKSVM-KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKE--H 1936
Query: 506 KEPPVKRSRSLSPKS-SFTD-SEELQKLR-KAERKIENLEKA-LQL------------KS 549
KE K +S K+ +D ++L K + + ++KI+ L+K LQL K
Sbjct: 1937 KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKI 1996
Query: 550 QENDELRDAHEKRKERLQMLQT-NYRAVKEQLKQWEE----GSGMTEIRKIKRADPQQLR 604
E ++L+ E + +Q ++ N++ K+ + EE E+R+IK + ++
Sbjct: 1997 NEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKES--LKME 2054
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERRE-- 662
++ A E+ R+N ++ +K L + L + + I+EL + +E +
Sbjct: 2055 RDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114
Query: 663 EQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSF-------EKRSRKLKEGN 715
E L R D LE+ ++ EL R+K+ K KL N
Sbjct: 2115 ECLNRLSLD---------------LEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTAN 2159
Query: 716 KKLMKE-NDFLKSLLKQQQEDTETREKELEQIIKGSKD----VEKENTELQVKISELETE 770
++ E + +K L T+ +E++ E I K D VEK+ EL +KI L+ +
Sbjct: 2160 QRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQK-ELLIKIQHLQQD 2218
Query: 771 VTSLRRQVAEANALRNENEEL-INPMEKSHQSADRAKSEMATMKVRSGRYDC-------- 821
R++ + N+N +L I + K ++ + +V S R +
Sbjct: 2219 CDVPSRELRDLKL--NQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWL 2276
Query: 822 --KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNV---FEN----LSKDGWEDVSESS 872
+ + K+K K+N + + + N+ I + N FE +SK+ +D+
Sbjct: 2277 NTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLK 2336
Query: 873 SDSEA--QTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKT 930
+E + QTL T + +Q T+D K+ + T+ ++ L
Sbjct: 2337 EKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSL------ 2390
Query: 931 PKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIIS 990
H+ + K KMQK V + + A+ SN L
Sbjct: 2391 -----HEAKESAMHKESKIIKMQKE------LEVTNDIIAKLQAKVHESNKCL------- 2432
Query: 991 LQQQNSVLQNAKKTAELSVKEYKEVNEKL-LHQQQVSDQRFQTSRQTIKKLNLDLAGLRK 1049
++ +Q + L K YKE E L + ++ ++ + +++ K+++ A +
Sbjct: 2433 -EKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEY 2491
Query: 1050 EKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSP----------SRSMDLEMKQLQY 1099
+KE +++ L + + A++ S ++ S P + L +K
Sbjct: 2492 QKE-VIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHI 2550
Query: 1100 KLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKV 1159
+L+ ++L +Q+ + K ELL+ +H+ +E + ER + + H ++V
Sbjct: 2551 RLEKEISKLKQQNEQLIKQKNELLSNNQHLS--NEVKTWKERTLKREAH--------KQV 2600
Query: 1160 NLESNKSFSEMLQNLDKKVKTLTEECSNKKV 1190
E++ ++ KK + +C + +
Sbjct: 2601 TCENSPKSPKVTGTASKKKQITPSQCKERNL 2631
Score = 67.4 bits (163), Expect = 9e-11
Identities = 132/663 (19%), Positives = 268/663 (40%), Gaps = 89/663 (13%)
Query: 735 DTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINP 794
+ T E L++ K D++K+ E+ ++ E L + + E + L+ E I
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 795 MEKSHQSADRAKSEMATMKVRSGRYD-CKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVM 853
+ + ++ + R R C + K+K ++ + T H + +
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI- 455
Query: 854 SNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTE--- 910
NL ++ E V S SD + T TL I + K+ E+ + + S +
Sbjct: 456 -----NLLREIDESVC-SESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDN 509
Query: 911 ---DSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRV--N 965
D + E + L + K D F K KK+ +MQ + + +
Sbjct: 510 LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKT----KKDQEMQLIHEISNLKNLVKH 565
Query: 966 REKYKNITAQKSSSNIILLRER---IISLQQ--QNSVLQNAKKTAELS---VKEYKEVNE 1017
E Y + SS + LLRE+ I LQ+ + L+N K S +++ K++ +
Sbjct: 566 AEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ 625
Query: 1018 KLLHQQQVS-----DQRFQTSRQT-IKKLNLDLAGLRKEKEDLLK----KLESSSEITSL 1067
L + V+ + F S +K+ +LA K+ E+ ++ +LE+ ++
Sbjct: 626 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685
Query: 1068 AEENSQVTFPRI-QVTSLSPSR-SMDLEMK-QLQYKLKNATNELTKQSSNVKTLKFELLA 1124
E+ Q F I ++TSL + DL +L+ K+ + EL K+ + L+ E++
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL 745
Query: 1125 KEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEE 1184
E +K + ++ R+ ++I K E+L + E +K FSE++ + +V+ L EE
Sbjct: 746 LSE-LKSLPSEVERLRKEIQDKS---EELHI---ITSEKDKLFSEVVHK-ESRVQGLLEE 797
Query: 1185 CSNKKVSIDSLKQRLNVAVKE-------KSQYEQMYQKSKEELEKKDLKLTLLVSRISET 1237
K + + + +E +EQ Y+ EE E+ + ++ L +
Sbjct: 798 IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 1238 ESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHV 1297
+S++ ++T S + QEL ++ +V E
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLN------------------------------ 887
Query: 1298 VRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAE 1357
++ +LK+ +NRD+ + + +TL L + +++ + +D ++ + + E
Sbjct: 888 ---EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
Query: 1358 NDK 1360
D+
Sbjct: 945 RDQ 947
Score = 42.7 bits (99), Expect = 0.002
Identities = 64/294 (21%), Positives = 125/294 (42%), Gaps = 41/294 (13%)
Query: 90 EGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVE 149
E EE T ++ E++L SLKE+ L+K Q L +
Sbjct: 2313 ESTEFEERSATISKEWEQDLKSLKEKNE----------KLFKNYQTLKTSLASGAQVNPT 2362
Query: 150 REKQKSEAKDRKVLEILQVKDAKIQEFEQ-----RESVLKQEINDLVKRKIAVDEENAFL 204
+ K+ + Q+ KI+E E +ES + +E + ++K + ++ N +
Sbjct: 2363 TQDNKNPHVTSRAT---QLTTEKIRELENSLHEAKESAMHKE-SKIIKMQKELEVTNDII 2418
Query: 205 RKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKL 264
K L+ K + ++ ++ TKE +Q +++ L K +EE + L + + DLEK+
Sbjct: 2419 AK----LQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKI--DLEKM 2472
Query: 265 RKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSL------QLSNKQ---- 314
K KE +T A ++ ++ + R+ + SQ + + Q SNK
Sbjct: 2473 -KNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCG 2531
Query: 315 --TELIQKDMDITLVRKEL---QELQNLYKQNSTHTAQQAELIQQLQVLNMDTQ 363
+ ++Q + L + + +E+ L +QN Q+ EL+ Q L+ + +
Sbjct: 2532 GGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVK 2585
Score = 36.2 bits (82), Expect = 0.23
Identities = 72/335 (21%), Positives = 138/335 (41%), Gaps = 36/335 (10%)
Query: 1089 SMDLEMKQLQYK-----LKNA--TNELTKQSSNVKTLKFELLAKEEHIKE--MHEKISRM 1139
S D + LQ+ +KN NE++ + +K + E++ ++ ++E + + M
Sbjct: 312 SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAM 371
Query: 1140 ERDITMKRHLIEDLKFRQKVNLESNKSFSEML---------QNLDKKVKTLTEECSNK-- 1188
E+D L+E+ QKV E ++ + ML Q L K K C K
Sbjct: 372 EKD--QLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKIN 429
Query: 1189 KVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIE-TA 1247
K+ + + N+ ++ ++ S L + D + S T ++EIE
Sbjct: 430 KMKNSNYADQFNIPTNITTKTHKL---SINLLREIDESVCSESDVFSNTLDTLSEIEWNP 486
Query: 1248 ASKQLQELALQSE-QVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELK 1306
A+K L + ++SE L L+L E++ ++ KE +ND+ R+ K
Sbjct: 487 ATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-KNDLDEFEALERKTK 545
Query: 1307 KMKKNR-----DACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDA---EN 1358
K ++ + K A+ + N S +E + + EDQ++ + ID+ EN
Sbjct: 546 KDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLEN 605
Query: 1359 DKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKK 1393
K + Y + +E L +A ++ K++
Sbjct: 606 IKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 165 bits (417), Expect = 3e-40
Identities = 278/1291 (21%), Positives = 542/1291 (41%), Gaps = 226/1291 (17%)
Query: 51 DESDK-----IWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEG---ISVEEAMV-TR 101
DE D+ I + EE G P ++ A +P S G +R E +SVE A +
Sbjct: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP--GMKRTESRQHLSVELADAKAK 259
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
+ L +EL E+L C+ + E + KRLQ N +L +S R
Sbjct: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS---------DARSARMYRD 310
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
L+ L+ K ++ + E S K+ ++D+ K V+E K+ +Q
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE---------------LKEDNQV 355
Query: 222 IKDTKECVQNKEEQNRL---VIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
+ +TK ++++ E R + LE+EN +L + D+ + + RK+ L +E +
Sbjct: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
+ K D + E+E + +++ +E QK + + L L
Sbjct: 416 EMAQKQSMDESLHLGWELE---------QISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
Query: 339 KQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNE 398
+N + T EL + + + K+L+ +++
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKE--------------------------N 500
Query: 399 AMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458
L + V L+++++Q+ K+ LQ Q L +E AQ+ ++E
Sbjct: 501 QRLSKKVEILENEIVQE-------KQSLQNCQNLSKDLMKEK-----AQLE-----KTIE 543
Query: 459 TLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSP 518
TL + + +I+ L+++ NE L++ +S+ R+ SAE + K+ +++ +
Sbjct: 544 TLRENSERQIKILEQE----NEHLNQTVSS----LRQRSQISAEARVKD--IEKENKILH 593
Query: 519 KSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELR-DAH--EKRKERLQMLQTNYRA 575
+S S +L K+ +R+I+ + + K + +EL + H EK E LQ TN +
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 576 VKEQLKQWEEGSGMTEI--RKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLE 633
E+++ E+ + E RK+K+ + + +L ++EN +L + + L
Sbjct: 654 TCEKIEALEQENSELERENRKLKKT------LDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 634 EELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQK 693
++ LK S+ A +Q N+ + E +EQL K G E+L+ + +K
Sbjct: 708 RNVESLKC-ASMKMAQLQLENKEL-ESEKEQL---------------KKGLELLKASFKK 750
Query: 694 VTELENRLKSFEKRSRKLKE----GNKKLMKENDFLKSL------LKQQQEDTETREKEL 743
LE + + +++L++ NKK+ + L+ L L++ E+ + K L
Sbjct: 751 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
Query: 744 EQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSAD 803
EQ+ K +K +E+E ++L+ +LE E LR+Q + EN I +EK +++
Sbjct: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Query: 804 RA----KSEMATMK---------VRSGRYDCKTTMT------KVKFKAAKKNCSVGRHHT 844
+ K +K V+ D KT +T K K + N + +
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK--- 927
Query: 845 VLNHSIKVMSNVFENLSKDGWEDVSESSSDS-----EAQTSQTLGTIIVETSQKISPTED 899
L H ++ + E L D +S+ DS E++ TL + +KI+ E
Sbjct: 928 -LTHELEKIGLNKERLLHD-----EQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE- 980
Query: 900 GKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTA 959
+ + T +Q +E+ N + + P ++ K ++ S
Sbjct: 981 ---ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES--- 1034
Query: 960 VPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKL 1019
Q+++ ++ +++R+I +++ N+ LQ K+ + +K+ + N L
Sbjct: 1035 ---------------QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1079
Query: 1020 ------LHQQQVSDQRFQTSRQTIK-KLNLDLAGLRKEKEDLL-KKLESSSEITSLAEEN 1071
L +Q VS Q T+ QT KL ++ + L + L+ + + + +SL EN
Sbjct: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1139
Query: 1072 SQVTFPRIQVTSLSPSRSMDLEMKQLQYK---------------LKNATNELTKQSSNVK 1116
V R + SL S D E +L ++ LK+A L + +++
Sbjct: 1140 ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE 1199
Query: 1117 TLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK 1176
+LL ++ ++++ EK+ ++E++ + L+E+ K + V E K E L+
Sbjct: 1200 DRYNQLLKQKGQLEDL-EKMLKVEQE----KMLLEN-KNHETVAAEYKKLCGEN-DRLNH 1252
Query: 1177 KVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSR--- 1233
L +E + +LK LN + E+++ E + K KE+ ++ D+ T L ++
Sbjct: 1253 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1312
Query: 1234 ISETESAMAEIETAASKQLQELALQSEQVLE 1264
+S+ + + E Q+Q L LQ+ +LE
Sbjct: 1313 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1343
Score = 127 bits (318), Expect = 1e-28
Identities = 188/942 (19%), Positives = 404/942 (42%), Gaps = 130/942 (13%)
Query: 524 DSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQW 583
D + ++ ++ IE L K + L + + RD H + L + +
Sbjct: 172 DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSA 231
Query: 584 EEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHI 643
+ G +++ + + D+ A ++ ++E +E Q ++ ++EL+++++ +
Sbjct: 232 QSPCGSPGMKRTESRQHLSVELADAKA---KIRRLRQELEEKTEQLLDCKQELEQMEIEL 288
Query: 644 SIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKS 703
K QE +++ R +++R DE+ + + LE + + E + ++
Sbjct: 289 ---KRLQQENMNLLSDARSARMYR----DELDALREKAVRVDKLESEVSRYKERLHDIEF 341
Query: 704 FEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVK 763
++ R +LKE N+ L++ K++L+ Q E T R +L ++ EKEN +L+ K
Sbjct: 342 YKARVEELKEDNQVLLET----KTMLEDQLEGTRARSDKLHEL-------EKENLQLKAK 390
Query: 764 ISELETEVTSLRRQVAEANALRNEN---------------------------EELINPME 796
+ ++E E R+++ E L EN EL +
Sbjct: 391 LHDMEMERDMDRKKIEE---LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447
Query: 797 KS--HQ-----SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHS 849
KS H+ S+ K EM + + +TT+ V+ A+K + + + L+
Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKENQRLSKK 506
Query: 850 IKVMSN--VFENLSKDGWEDVSESSSDSEAQTSQTLGT----------IIVETSQKISPT 897
++++ N V E S +++S+ +AQ +T+ T I+ + ++ ++ T
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 898 EDGKDQKESDPTE----DSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQ 953
Q+ E D + + K + ++ K K F + KK + ++ K +
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK---ELEHYKEK 623
Query: 954 KSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYK 1013
+ ++ + +N QK +N+ + E+I +L+Q+NS L+ + + ++ +K
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 1014 EVNEKL----LHQQQVSDQRFQTSR--QTIKKLNLDLAGLRKEKEDLLKKLESSSEITSL 1067
+ +L Q+ ++ + R +++K ++ +A L+ E K+LES E
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN----KELESEKEQLKK 739
Query: 1068 AEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEE 1127
E + +F + + +S + +D+E ++LQ L+N+ ++ + S ++ L+ E ++
Sbjct: 740 GLELLKASFKKTERLEVS-YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 1128 HIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSN 1187
+++E+ R+E+ + L ++ +K + K + Q + K TL E
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN--- 855
Query: 1188 KKVSIDSLKQRLNVAVKEKSQYEQMYQKSKE-ELEKKDLK----------LTL---LVSR 1233
V I +L++ KE Y++ + KE E E K+L +TL LVS
Sbjct: 856 -NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914
Query: 1234 ISETESAMAEIETAASKQLQELALQSEQVLEGAQKT----LLLANEKVEEFTTF------ 1283
+T+ ++E + +L+++ L E++L Q T L K+E
Sbjct: 915 KLKTQQMNNDLEKL-THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKE 973
Query: 1284 --VKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAAS---------ILNI 1332
+ AL L+ + ++ +ELK +KKN +A K + + + +S
Sbjct: 974 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033
Query: 1333 SRSDLEEILDTEDQ-VEIEKTKIDAENDKEWMLYIQKLLEGQ 1373
S+ E+L +D+ +E+E+ + +K+ + K LE Q
Sbjct: 1034 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
Score = 33.9 bits (76), Expect = 1.1
Identities = 99/493 (20%), Positives = 200/493 (40%), Gaps = 67/493 (13%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS-LVVEREKQKSEAKDRKVL 163
LE+ L +E++ L + E V + +K+L N L S L+ E E +++ K+ K L
Sbjct: 1215 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1274
Query: 164 EILQVKDAKIQE--FEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
+ ++K+++ E S LK++ L ++ + L S L+ +++++
Sbjct: 1275 ----LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL----SQLKGNLEEENRH 1326
Query: 222 IKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAK 281
+ D +Q QNR +++ E ++ L +LR+Q+ L +EK K
Sbjct: 1327 LLDQ---IQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL-EEKIMDQYK 1382
Query: 282 -------------IKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI----QKDMDI 324
I LI+++K++ + K L+ S+ + Q D
Sbjct: 1383 FYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDS 1442
Query: 325 TLV-RKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKL 383
+ V L++ Q L + S + +L+Q + + T + E++ + IS K
Sbjct: 1443 SSVGSNSLEDGQTLGTKKS---STMNDLVQSMVLAGQWT----GSTENLEVPDDISTGKR 1495
Query: 384 YNEL-HICFETT-------------KSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQES 429
EL + F TT +S + + + T+ +D Q +++ ++ S
Sbjct: 1496 RKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHAS 1555
Query: 430 QGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQE---KLKIANEKLSENI 486
+ A L +S ++ + SL ++ V+ +S + L +E S +
Sbjct: 1556 RPASL----DSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSG 1611
Query: 487 SANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSE--ELQKLRKAERKIENLEKA 544
S+ + ++ +S +HK SR K+ SE LQ+ + K+ +
Sbjct: 1612 SSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKL----TS 1667
Query: 545 LQLKSQENDELRD 557
+Q+KS + L D
Sbjct: 1668 VQIKSSSQENLLD 1680
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 151 bits (381), Expect = 5e-36
Identities = 266/1316 (20%), Positives = 541/1316 (41%), Gaps = 227/1316 (17%)
Query: 108 ELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQ 167
EL SL+++L Q + +++ + + Q+ + + + + + E +R + E +
Sbjct: 136 ELQSLEQQLEEAQTEN---FNIKQMKDLFEQKAAQLATEIADIKSKYDE--ERSLREAAE 190
Query: 168 VKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD-------KSQ 220
K ++ E +E+ + Q++ + ++ + E+ A L+KE ++ + +S+
Sbjct: 191 QKVTRLTEELNKEATVIQDLKTELLQRPGI-EDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 221 EIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDA 280
++KD + +Q++ + I L E K + +L+KL+ L +
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ------- 302
Query: 281 KIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQ 340
K +T +NL++ ++ + K+N S+ N Q L QKD+D ++ L + +
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 341 NSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKL---YNELHICFETTKSN 397
+++ E TQK+ +V T YQ L + +L E + +
Sbjct: 363 IHVELSEKGEA----------TQKLKEELSEVET----KYQHLKAEFKQLQQQREEKEQH 408
Query: 398 EAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSL 457
L+ + L +LL+ E++ + +L+E + LSS
Sbjct: 409 GLQLQSEINQLHSKLLETERQLGEAHGRLKEQR----------------------QLSS- 445
Query: 458 ETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLS 517
E LM ++ ++ LQ KL E+L E ++ + + T + + ++ +++S +
Sbjct: 446 EKLM-DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ-ALQQSTTAK 503
Query: 518 PKSSFTDSEE-LQKLRKAERKIENLEKALQLKSQENDELRD-----------AHEKRKER 565
+ + D E+ L+++ ++KI+NLE LQ KS+EN L + A E
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQ-KSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 566 LQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQEL 625
L LQ ++EQ+ Q +TE K + +Q ++ D V + A+ + +
Sbjct: 563 LNQLQEKNHTLQEQVTQ------LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 626 MIQKMNLEE-------------ELD----------------------ELKVHISIDKAAI 650
+ + ++ E +LD +L+ H+ + A+
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676
Query: 651 ----QELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTL---QKVTELENRLKS 703
QELN+ + +Q+ +D + S E + KE E+ L QK ELE ++K
Sbjct: 677 QDKQQELNKITTQL--DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734
Query: 704 FEKRSRKLKEGNKKLMKENDFLKSLLKQQQE---DTETREKELEQIIKGSKD-VEKENTE 759
E S ++K ++ +++ L+QQ++ D E R EL + ++ K+ V +
Sbjct: 735 LEADSLEVKASKEQALQD-------LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD 787
Query: 760 LQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMAT--MKVRSG 817
LQ K LE+ L +Q E L+ + E L + H+ + T KV+
Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847
Query: 818 RYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEA 877
+ T ++ VK K +K ++ S+K + FE ++ G + D E
Sbjct: 848 KEALMTELSTVKDKLSK-----------VSDSLKNSKSEFEKENQKG----KAAILDLEK 892
Query: 878 QTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHD 937
+ + V+ + K+QKE + + + + ++ LN +
Sbjct: 893 TCKELKHQLQVQMENTL------KEQKELKKSLEKEKEASHQLKLELN---SMQEQLIQA 943
Query: 938 KNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSV 997
+N K Q + + Q + + + +K K I A + I +L++ + + Q +
Sbjct: 944 QNTLK---QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
Q A++ A EK+ V ++ S++T K+L D G E +
Sbjct: 1001 TQAAQELA--------AEKEKI----SVLQNNYEKSQETFKQLQSDFYGRESELLATRQD 1048
Query: 1058 LESSSEITSLAEE----------NSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNE 1107
L+S E SLA+E N ++ + + + +QLQ + K A +
Sbjct: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK-ALQD 1107
Query: 1108 LTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDIT-----MKRHLIEDLKFRQKVNLE 1162
+ K+ S + EL+ ++ + E+ E R E++IT +K H +E +K + NL+
Sbjct: 1108 IQKEKS---LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK--EITNLK 1162
Query: 1163 SNKSF-----SEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYE-QMYQKS 1216
K E+ D + +E N+++ D +K+ KE + E +++ +
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI 1222
Query: 1217 KE------ELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQ------VLE 1264
KE + E+ + KLT+ ++ ++E + + ++ +++ EL Q++ VLE
Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
Query: 1265 GAQKT-----------LLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMK 1309
+ L ++E+ T V L ++L N V+ RE + ++
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 135 bits (341), Expect = 2e-31
Identities = 215/1120 (19%), Positives = 469/1120 (41%), Gaps = 124/1120 (11%)
Query: 314 QTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVH 373
++ L K D+TL+R+E+Q+LQ K+ ++ + + +++ Q L K + +
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK----PDGLV 130
Query: 374 TAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAP 433
T S Q L +L E ++ ++Q + + Q E A +K K E +
Sbjct: 131 TDSSAELQSLEQQL----EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186
Query: 434 LPLPQESD-------------PDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANE 480
Q+ D ++ RP + + L + +++ L + + + E
Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK-KELVQVQTLMDNMTLERE 245
Query: 481 KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKA----ER 536
+ SE + K +K A + ++ + P+ +ELQKL+ + +
Sbjct: 246 RESEKL---KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ 302
Query: 537 KIENLEKALQLKSQENDELRDAHEKRKERLQMLQT-------NYRAVKEQLKQWEEGSGM 589
K + L + L K Q+ +L + H + + +Q + + ++ +L E
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362
Query: 590 TEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAA 649
+ ++ + Q +E+ V + + K E ++L Q+ E+ +L+ I+ +
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 650 IQELNRCVAE---RREEQLFRSGE----------DDEVKRSTPEKNGKEMLEQTLQKVTE 696
+ E R + E R +EQ S E D ++K S E+ KE + + + +
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 697 LENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKD---- 752
L+ + +++ + KL + + L+ +L+ Q D + + + LE +++ SK+
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR-QIGDKDQKIQNLEALLQKSKENISL 541
Query: 753 VEKENTELQVKI----------SELETEVTSLRRQVAE-ANALRNENEELINPMEKSHQS 801
+EKE +L KI ++L+ + +L+ QV + L+N++E E H
Sbjct: 542 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 601
Query: 802 ADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLS 861
K+ + + R + + +K+ S L+ IK + + LS
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS------QLDIQIKAKTELL--LS 653
Query: 862 KDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTED-SQTQG--KE 918
+ + + + T+Q + KI+ D K D E SQ + KE
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Query: 919 IVQTYLNIDGKTPK----------DYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREK 968
+ YL+++ KT + D K +K+ Q + + Q+ +T + R E
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ--DLQQQRQLNTDLELRAT-EL 770
Query: 969 YKNITAQKS--SSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVS 1026
K + +K SS + L+++ +L+ L ++ ++ ++++ ++++ Q +
Sbjct: 771 SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
Query: 1027 DQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSP 1086
+ R QT+ ++K+ ++ L E + KL S+ + +NS+ F + +
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD----SLKNSKSEFEKENQKGKAA 886
Query: 1087 SRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMK 1146
++ K+L+++L Q TLK +++ +K+ EK + ++
Sbjct: 887 ILDLEKTCKELKHQL---------QVQMENTLK-----EQKELKKSLEKEKEASHQLKLE 932
Query: 1147 RHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEK 1206
+ +++ + + L+ N+ + LQ + L + KK I++L+ L +AV +K
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQG---NINELKQSSEQKKKQIEALQGELKIAVLQK 989
Query: 1207 SQYE----QMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQV 1262
++ E Q ++ +EL + K+++L + +++ ++++ + EL L + Q
Sbjct: 990 TELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL-LATRQD 1048
Query: 1263 LEGAQKTLLLANEKVEEFTTFV---KALAKELQNDVHVVRRQIRELKKMKKNRDACKT-- 1317
L+ ++ L LA E + + L +EL+ + + KK ++ ++ CK
Sbjct: 1049 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD--SAKKEQQLQERCKALQ 1106
Query: 1318 STHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAE 1357
K ++L L +S L EI + + + E E TK++ E
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE 1146
Score = 124 bits (312), Expect = 5e-28
Identities = 216/1070 (20%), Positives = 439/1070 (41%), Gaps = 117/1070 (10%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQV-VSLVVEREKQKSEAKDRKVLE 164
EE +S + L Q D + L RL + L ++ V L +K EA +K+ E
Sbjct: 327 EESVSKKNIQATLHQKDLD-CQQLQSRLSASETSLHRIHVEL-----SEKGEAT-QKLKE 379
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
L + K Q + L+Q+ + + + + E L + + E++ + +K+
Sbjct: 380 ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE 439
Query: 225 TK----ECVQNKEEQN---RLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+ E + +KE+Q +L + LEE+ K+ T T+L + L+K ++Q + + S
Sbjct: 440 QRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQS 499
Query: 278 TDAKIKTFEDNLIEARKEVEVSQSKYNALS--LQLSNKQTELIQKDMD-----------I 324
T AK++ +++L + +++ K L LQ S + L++K+ +
Sbjct: 500 TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE 559
Query: 325 TLVRKELQE------------LQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
T V +LQE + L Q+ +H Q L Q+Q + + LR +D
Sbjct: 560 TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ----EQKAHLRAAQDR 615
Query: 373 HTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGA 432
+ S +L ++L+ E + ++ L K + A L+ L +Q A
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 433 PLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGF 492
QE + + L + +S ++ +EK +K E K
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 493 SRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQEN 552
S+ A + +++ R L+ +E ++L + + + LQ KS+
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL 795
Query: 553 DELRDAHEKRKERLQMLQTNYRAVKEQLK-QWEE-----GSGMTEIRKIKRADPQQLRQ- 605
+ ++ K++E Q+L+ ++ + ++ K Q EE + +TE++K+K + +
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 606 --------EDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCV 657
+ SD++ N + F++ENQ+ ++LE+ ELK + + ++ +
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV------QMENTL 909
Query: 658 AERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKK 717
E++E L +S E ++ + M EQ +Q +N LK EK ++L +GN
Sbjct: 910 KEQKE--LKKSLEKEKEASHQLKLELNSMQEQLIQ----AQNTLKQNEKEEQQL-QGN-- 960
Query: 718 LMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQ 777
+ + ++ +E ++K++E + K + TEL+ K+ + L +
Sbjct: 961 -----------INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ------QLTQA 1003
Query: 778 VAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNC 837
E A + + L N EKS ++ + +S+ GR + + T+ K+ ++
Sbjct: 1004 AQELAAEKEKISVLQNNYEKSQETFKQLQSDF------YGR-ESELLATRQDLKSVEEKL 1056
Query: 838 SVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQ---TLGTIIVETSQKI 894
S+ + + N + N K + + S+ E Q + L I E S K
Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
Query: 895 SPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTP-----KDYFHDKNAKKPTFQKKN 949
+ K K ++ E Q KEI T LN + K+ K+ + K+AK+ Q+K
Sbjct: 1117 KELVNEK-SKLAEIEEIKCRQEKEI--TKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 950 CKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSV 1009
K+ + + + Q L +E I ++ + L + K E+ +
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI----EKEAKLHSEIKEKEVGM 1229
Query: 1010 KEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAE 1069
K+++E KL Q ++ T ++ + ++ L K+ +DL ++ +
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289
Query: 1070 ENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNAT---NELTKQSSNVK 1116
+ + R + + ++ +LQ KL N T EL +++ +++
Sbjct: 1290 DERRALLERC-LKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 115 bits (289), Expect = 2e-25
Identities = 195/1025 (19%), Positives = 438/1025 (42%), Gaps = 135/1025 (13%)
Query: 395 KSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSL 454
+ + +LRQ V +LQ L +++ + +LK++L++ QG QE+ PD
Sbjct: 82 RDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ---QQEAKPD----------- 127
Query: 455 SSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKG-FSRKSIMTSAEGKHKEPPVKRS 513
L+ +E++ L+++L+ A + + NI K F +K+ + E +
Sbjct: 128 ----GLVTDSSAELQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLATEIADIKSKYDEE 182
Query: 514 RSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKE--RLQMLQT 571
RSL + + ++L K I++L+ L + + D +KE ++Q L
Sbjct: 183 RSLREAAEQKVTRLTEELNKEATVIQDLKTELL----QRPGIEDVAVLKKELVQVQTLMD 238
Query: 572 NYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNEL-AYFKRENQELMIQKM 630
N +E+ E E +K+ Q + S+A ++L + + QE+ +
Sbjct: 239 NMTLERER----ESEKLKDECKKL------QSQYASSEATISQLRSELAKGPQEVAVYV- 287
Query: 631 NLEEELDELKVHISIDKAAIQELNRCVAER--REEQLFRSGEDDEVKRSTPEKNGKEMLE 688
+EL +LK ++ + + N+ + E ++EQ + E+ + S +KN + L
Sbjct: 288 ---QELQKLKSSVN----ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 340
Query: 689 QTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIK 748
Q +L++RL + E ++ + + LK L + + + + E +Q+ +
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400
Query: 749 GSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINP--MEKSHQSADRAK 806
++ E+ +LQ +I++L +++ RQ+ EA+ E +L + M+K Q AD
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD--- 457
Query: 807 SEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWE 866
++ ++ + T T+++ + K + + + +L E
Sbjct: 458 LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL-----E 512
Query: 867 DVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNI 926
V D + Q Q L ++ ++ + IS E ++E + +G+ V L
Sbjct: 513 QVLRQIGDKD-QKIQNLEALLQKSKENISLLE---KEREDLYAKIQAGEGETAVLNQLQE 568
Query: 927 DGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRE 986
T ++ K + + + Q++ H V Q+ +++ ++
Sbjct: 569 KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV--------------QEQKAHLRAAQD 614
Query: 987 RIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAG 1046
R++SL E SV E + + S++ + +L++ +
Sbjct: 615 RVLSL--------------ETSVNEL--------------NSQLNESKEKVSQLDIQI-- 644
Query: 1047 LRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATN 1106
K K +LL E++ +N T + ++ Q+ KL++
Sbjct: 645 --KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 1107 ELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDI----TMKRHLIEDLKFRQKVNLE 1162
++ S++K K + L+ E+ +E+ +I ++E D K ++DL+ ++++N +
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 1163 SNKSFSEMLQNLDKK---VKTLTEECSNKKVSIDSLKQRLNVAVKE----KSQYEQMYQK 1215
+E+ + L+ + V + + K +++S+KQ+L +E K +E + Q+
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822
Query: 1216 SKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANE 1275
+K + E+ + ++ V+ + + + + T S +L+ S+ L+ ++ N+
Sbjct: 823 TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS-LKNSKSEFEKENQ 881
Query: 1276 KVEEFTTFVKALAKELQNDVHV-VRRQIRELKKMKKNRDACKTSTHKAQTLAASI---LN 1331
K + ++ KEL++ + V + ++E K++KK+ + K ++H+ + S+ L
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
Query: 1332 ISRSDLEEILDTEDQVE--IEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKIN 1389
+++ L++ E Q++ I + K +E K+ + + L+G+L AVL+K
Sbjct: 942 QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI----EALQGELKI------AVLQKTE 991
Query: 1390 EKKKL 1394
+ KL
Sbjct: 992 LENKL 996
Score = 90.9 bits (224), Expect = 8e-18
Identities = 131/623 (21%), Positives = 267/623 (42%), Gaps = 79/623 (12%)
Query: 92 ISVEEAMVTRTQL----LEEELSSLKEELALCQADKEFVW----SLWKRLQVTNPDLT-Q 142
+ +E+ +V+ T+L E L S+K++L + +K+ + +L + ++ + +L +
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 143 VVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENA 202
+ + V E +K K E K+ + E+ VKD L + + L K ++EN
Sbjct: 834 IQTTVTELQKVKME-KEALMTELSTVKDK-----------LSKVSDSLKNSKSEFEKENQ 881
Query: 203 FLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLE 262
+ DLEK K+ +++ E ++++ + ++ +E + +L + L
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
Query: 263 KLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQ---LSNK-QTELI 318
+ + KE+ I + + + +K++E Q + LQ L NK Q +L
Sbjct: 942 QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001
Query: 319 QKDMDITLVRKELQELQNLYKQN--------STHTAQQAELIQQLQVLNMDTQKVLRNQE 370
Q ++ ++++ LQN Y+++ S +++EL+ Q L +K+ QE
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 371 DVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQ 430
D+ IS + + + K+ +A L EQ++AK +++LQE
Sbjct: 1062 DL-----ISNRNQIGNQNKLIQELKTAKATL--------------EQDSAKKEQQLQERC 1102
Query: 431 GAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANK 490
A + +E V + L+ +E + Q+ EI L E+LK + + I+ K
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 491 GFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQ 550
+ I E + K +K + ++ ++++K + E K E +EK +L S+
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK-EEEELKKEFIEKEAKLHSE 1221
Query: 551 --ENDELRDAHEKRKERLQM----LQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
E + HE+ + +L M L N VK K+W+ R++ + Q
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVK---KEWQSSQ-----RRVSELEKQTDD 1273
Query: 605 QEDSDAVWNELAYFKRENQELMIQKM--------NLEEELDELKVHISIDKAAIQEL--- 653
AV ++ + ++++ L+ ++ EL+ + AA+QEL
Sbjct: 1274 LRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333
Query: 654 NRCVAERREEQLFRS-GEDDEVK 675
N+ + + + L R ED+EV+
Sbjct: 1334 NQSLQIKHTQALNRKWAEDNEVQ 1356
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 145 bits (366), Expect = 3e-34
Identities = 250/1302 (19%), Positives = 533/1302 (40%), Gaps = 242/1302 (18%)
Query: 104 LLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR--- 160
+LEE++ +L+ E++ K L+ L Q +V+E+E+ E+K+
Sbjct: 288 ILEEQIINLEAEVSAQD----------KVLREAENKLEQSQKMVIEKEQSLQESKEECIK 337
Query: 161 -KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKS 219
KV + Q K K E ++ E++ E +L K F+
Sbjct: 338 LKVDLLEQTKQGKRAERQRNEALYNAE-----------------------ELSKAFQQYK 374
Query: 220 QEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTD 279
+++ + E VQ +EE + N E+ENK+L RC ++LE L+++ L++E +
Sbjct: 375 KKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGK 434
Query: 280 AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYK 339
K++ E ++ S+ L +L NK E+++ + +EL
Sbjct: 435 EKLRIMAVKNSEVMAQLTESRQSILKLESELENKD-EILRDKFSLMNENREL-------- 485
Query: 340 QNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEA 399
+ + Q + L++ Q++ ++ ++ + E I Q F++ S
Sbjct: 486 --------KVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQ 537
Query: 400 MLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLET 459
M S +N +D+ + + N + +S L
Sbjct: 538 M--SSFSNKEDRCIGCCEANKLV-------------------------------ISELRI 564
Query: 460 LMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPK 519
+ +++EI +KL N++AN + S+SL
Sbjct: 565 KLAIKEAEI-----------QKLHANLTAN---------------------QLSQSLITC 592
Query: 520 SSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQ 579
+ +S +L L K+ + A +K Q + +EK ++R L T ++ +
Sbjct: 593 NDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQR---LVTGIEELRTK 649
Query: 580 LKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDEL 639
L Q E + ++ R QL QE+ + + + E + Q + LE++L+E
Sbjct: 650 LIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEK 709
Query: 640 KVHISIDKAAIQELNRCVAERREEQLFRSGE-----DDEVKRSTPEKNGKEMLEQTLQKV 694
V S A EL + + E+ E+ RS E + E EK K LEQ +
Sbjct: 710 IVAYSSIAAKNAELEQELMEKNEK--IRSLETNINTEHEKICLAFEKAKKIHLEQHKEME 767
Query: 695 TELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSK-DV 753
++E EK+ ++ KE K + S+L+Q + + L++++ SK ++
Sbjct: 768 KQIERLEAQLEKKDQQFKEQEKTM--------SMLQQDIICKQHHLESLDRLLTESKGEM 819
Query: 754 EKENTELQVKISELETEVTSLRRQVAEA-NALRNENEELINPMEKSHQSADRAKSEMATM 812
+KEN + + L+ +V+ +V + +AL EEL+ + + + ++ + + +
Sbjct: 820 KKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQ---L 876
Query: 813 KVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESS 872
K +S C K+K + ++ + +L H+++ + + E+
Sbjct: 877 KKKSEEVYCLQKELKIKNHSLQE---TSEQNVILQHTLQQQQQMLQ----------QETI 923
Query: 873 SDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPK 932
+ E + +QT + +++S E ++ Q Q + + ++ K +
Sbjct: 924 RNGELEDTQT------KLEKQVSKLE-----------QELQKQRESSAEKLRKMEEKC-E 965
Query: 933 DYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRE---RII 989
H+ + K+ K+ + + TA ++ ++YK ++ + L R+ + +
Sbjct: 966 SAAHEADLKRQ-------KVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAM 1018
Query: 990 SLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRK 1049
L Q + +L K E KE+ EKL H ++ + Q + L +L
Sbjct: 1019 HLSQLDMILDQTKTELEKKTNAVKEL-EKLQHS---TETELTEALQKREVLETELQNAHG 1074
Query: 1050 EKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELT 1109
E + L++L+ ++ A+ + + + I + + E+++ + ++++ EL
Sbjct: 1075 ELKSTLRQLQELRDVLQKAQLSLEEKYTTI--------KDLTAELRECKMEIEDKKQELL 1126
Query: 1110 KQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQK-VNLESNKSFS 1168
+ +K +EL + + + D+T++ H E QK + LE S
Sbjct: 1127 EMDQALKERNWELKQRAAQVTHL---------DMTIREHRGE---MEQKIIKLEGTLEKS 1174
Query: 1169 EM-LQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKL 1227
E+ L+ +K++++L ++ N K + L+++ + ++ + + Q+ K+E+E+
Sbjct: 1175 ELELKECNKQIESLNDKLQNAK---EQLREKEFIMLQNEQEISQL----KKEIER----- 1222
Query: 1228 TLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL 1287
T+ M E+E+ +Q Q +A Q ++ ++ Q+ L + T +A
Sbjct: 1223 ---------TQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEAR 1273
Query: 1288 AKEL--QNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTED 1345
+++ Q ++ + ++ ++K++ K +DA H A+ L AS + E L+
Sbjct: 1274 HQQVQAQREIERLSSELEDMKQLSKEKDA--HGNHLAEELGASKVR------EAHLEARM 1325
Query: 1346 QVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEK 1387
Q EI+K + E+ KE Y +++ Q A + + A +K
Sbjct: 1326 QAEIKKLSAEVESLKE--AYHMEMISHQENHAKWKISADSQK 1365
Score = 119 bits (297), Expect = 3e-26
Identities = 190/967 (19%), Positives = 406/967 (41%), Gaps = 104/967 (10%)
Query: 428 ESQGAPLPLP-----QESDPDYSAQVPHRPSL----SSLETLMVSQKSEIEYLQEKLKIA 478
+S G LP + S DY + SL +SL + + ++ L E+L
Sbjct: 105 QSPGGSLPSDDLGEMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSV 164
Query: 479 NEKLSENISANKGFSRKSIMT---SAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAE 535
+ + + + N S K I+ S G P + +S S+ + K+ +
Sbjct: 165 SPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSS 224
Query: 536 RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKI 595
++ K+L+ K ++LR + + L T + ++ +L Q M E +
Sbjct: 225 APVDQEIKSLREKL---NKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQ 281
Query: 596 KRADPQQLRQE---------DSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISID 646
+ A L ++ D V E ++Q+++I+K +E E + + +D
Sbjct: 282 QAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVD 341
Query: 647 KAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEK 706
+ + +R E L+ + E + + +K E LE+ + LE L + EK
Sbjct: 342 LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVA-EKLEKVQAEEEILERNLTNCEK 400
Query: 707 RSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISE 766
+++L+E E + LK L+Q +E+ +++L + + +V + TE + I +
Sbjct: 401 ENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK 460
Query: 767 LETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMT 826
LE+E+ + + + +L NEN EL K +A + ++ ++ S R + + ++
Sbjct: 461 LESELENKDEILRDKFSLMNENREL-----KVRVAAQNERLDLCQQEIESSRVELR-SLE 514
Query: 827 KVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFE------NLSKDGWEDVSESSSDSEAQTS 880
K+ + K G + + + SN + +K ++ + EA+
Sbjct: 515 KIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQ 574
Query: 881 QTLGTIIV-ETSQKISPTEDGKDQKE--SDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHD 937
+ + + SQ + D ++ + S TE + G ++ ++
Sbjct: 575 KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESV-------------- 620
Query: 938 KNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSV 997
K+ + T K+ K ++ T + R K I A+ S + + Q +
Sbjct: 621 KDQNQHTMNKQYEKERQRLVTGIEEL--RTKLIQIEAENSDLKVNMAHRTSQFQLIQEEL 678
Query: 998 LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKK 1057
L+ A +++L + K+ ++ L ++Q+ ++ S +I N +L EK + ++
Sbjct: 679 LEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYS--SIAAKNAELEQELMEKNEKIRS 736
Query: 1058 LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKT 1117
LE T++ E+ ++ + ++ + LE Q+K E+ KQ ++
Sbjct: 737 LE-----TNINTEHEKICL------AFEKAKKIHLE----QHK------EMEKQ---IER 772
Query: 1118 LKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKK 1177
L+ +L K++ KE + +S +++DI K+H +E L ++ ES + D+
Sbjct: 773 LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESL---DRLLTESKGEMKKENMKKDEA 829
Query: 1178 VKTLTEECSNKKVSIDSLKQRLNVAVKE----KSQYEQMYQKSKEELEKKDLKLTLLVSR 1233
+K L + S + + + L L + +E +Q E +K +++L+KK ++ L
Sbjct: 830 LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
Query: 1234 ISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQN 1293
+ ++ E + + LQ Q +Q+L+ Q+T + N ++E+ T ++ +L+
Sbjct: 890 LKIKNHSLQE-TSEQNVILQHTLQQQQQMLQ--QET--IRNGELEDTQTKLEKQVSKLEQ 944
Query: 1294 DVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTK 1353
++ R E K++K + C+++ H+A ++ R + E+ T QV+IE +
Sbjct: 945 ELQKQRESSAE--KLRKMEEKCESAAHEA--------DLKRQKVIELTGTARQVKIEMDQ 994
Query: 1354 IDAENDK 1360
E K
Sbjct: 995 YKEELSK 1001
Score = 32.3 bits (72), Expect = 3.3
Identities = 64/322 (19%), Positives = 129/322 (40%), Gaps = 32/322 (9%)
Query: 1093 EMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMER--------DIT 1144
EM+ N NE +NV +L+ EL E ++ + E++S + + +
Sbjct: 118 EMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPS 177
Query: 1145 MKRHLIEDLKFRQKVNL-----ESNKSFSEMLQNLDKKVKT-LTEECSNKKVSIDSLKQR 1198
LI D++ L E+ S + KK + + + I SL+++
Sbjct: 178 RSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREK 237
Query: 1199 LNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQ 1258
LN ++ + + E +LT +++S ESA + A+ L+E +
Sbjct: 238 LNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQ--AASVPILEEQIIN 295
Query: 1259 SEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQ-NDVHVVRRQIRELKKMKKNRDACK- 1316
E + K L A K+E+ V + LQ + ++ ++ L++ K+ + A +
Sbjct: 296 LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQ 355
Query: 1317 --TSTHKAQTLAASILNISR---SDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLE 1371
+ + A+ L+ + + LE++ E+ +E T + EN K L+
Sbjct: 356 RNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKEN---------KRLQ 406
Query: 1372 GQLPFASYLLEAVLEKINEKKK 1393
+ LE + EK+ + K+
Sbjct: 407 ERCGLYKSELEILKEKLRQLKE 428
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 143 bits (361), Expect = 1e-33
Identities = 266/1278 (20%), Positives = 524/1278 (41%), Gaps = 127/1278 (9%)
Query: 75 AHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRL- 133
A L + SR L GI E+A+ R + C KE +R
Sbjct: 1641 ARLQLQGLDLSSRSLLGIDTEDAIQGRNES--------------CDISKEHTSETTERTP 1686
Query: 134 -----QVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN 188
Q+ + D Q ++L +E+ + K Q D +E Q +
Sbjct: 1687 KHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN---YEPPGEDKTQGSS 1743
Query: 189 DLVKRKIAVDEENAFLRKEF-------SDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIK 241
+ + +++ NA + +F +L+ + K+ S E +++++ + ++
Sbjct: 1744 ECIS-ELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLN 1802
Query: 242 NLEEENKKLSTRCTDLLNDLE---KLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEV 298
++E + KL + L+ +E +L K L+KE K++ F + E + VE
Sbjct: 1803 EMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVET 1862
Query: 299 SQSKYNALSLQLSNKQTELIQKDMDITLVRKELQE-LQNLYKQNSTHTAQQAELIQQLQV 357
S+ + L + E I + + V +E ++ + S +++A + +
Sbjct: 1863 SEGLNSDLEMHADKSSREDIGDN--VAKVNDSWKERFLDVENELSRIRSEKASIEHEALY 1920
Query: 358 LNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQ 417
L D + V++ ++ ++ + QK+ L S LR + + + +Q
Sbjct: 1921 LEADLE-VVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQ 1979
Query: 418 ENAKLKEKLQE---SQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEK 474
+ K+KEK QE Q L Q ++ + + +LSS + ++ K+ +LQEK
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKT---HLQEK 2036
Query: 475 LKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKA 534
L+ + EK S+ +S K I + K KE VK S SL + S +D E+L +
Sbjct: 2037 LQ-SLEKDSQALSLTKCELENQI--AQLNKEKELLVKESESLQARLSESDYEKLNVSKAL 2093
Query: 535 ERK-IENLEKALQLKSQEND--ELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTE 591
E +E E AL+L S + + +LR EK + R++ + + E+LK+ E + +
Sbjct: 2094 EAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLK 2153
Query: 592 IRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQ--------------KMNLEEELD 637
+ Q+ +E+ + V + K E + L Q + L E +
Sbjct: 2154 DKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE 2213
Query: 638 ELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTEL 697
L I + + EL++ ++ + L E E++ K EML+ L+++ E
Sbjct: 2214 NLTKQIQEKQGQLSELDKLLSSFKS--LLEEKEQAEIQIKEESKTAVEMLQNQLKELNEA 2271
Query: 698 ENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKEN 757
L ++ + ++ ++E L++ +++ + E EK+ +++ K+ E
Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
Query: 758 TELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSG 817
L+ ++ LE E+ + R E AL EN K +AK E T +R
Sbjct: 2332 DLLKGRVENLEREL-EIARTNQEHAALEAENS-------KGEVETLKAKIEGMTQSLRGL 2383
Query: 818 RYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHS-IKVMSNVFENLSKDGWEDVSESSSDSE 876
D T ++ K+N + S ++++++ FEN+ ++ E +
Sbjct: 2384 ELDVVT------IRSEKENLTNELQKEQERISELEIINSSFENILQEK-EQEKVQMKEKS 2436
Query: 877 AQTSQTLGTIIVETSQKISPTEDGKDQ-KESDPTEDSQTQGKEIVQTYLNIDGKTPKDYF 935
+ + L T + E +++++ + ++ K + SQ + E+ + L + G
Sbjct: 2437 STAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQL-LQGLDEA--- 2492
Query: 936 HDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQN 995
K N + +SS + V K K +K I L+ +I +Q
Sbjct: 2493 -----------KNNYIVLQSSVNGLIQEVEDGKQK---LEKKDEEISRLKNQIQDQEQLV 2538
Query: 996 SVLQNAKKTAELSVK---EYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKE 1052
S L + +L + E + + +L + QV + + + T++ L L E E
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Query: 1053 ----DLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
D + +E +++T+ E + Q T+ + E +L +L+ E+
Sbjct: 2599 LTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA-ELQEELSGEKNRLAGELQLLLEEI 2657
Query: 1109 TKQSSNVKTLKFELLAKEEHIKEMH----EKISRMERDIT-MKRHLIEDLKFRQKVNLES 1163
+K L E ++ + MH EK ++ +I + L E K Q + L++
Sbjct: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 1164 NKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLK---QRLNVAVKEKSQYEQMYQKSKEEL 1220
NK + +Q +K+ + E S++K+ ID LK + LN ++K +Q + +K+K +
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMD- 2776
Query: 1221 EKKDLKLTLLVSRISETESAMAEIETAASKQLQELA--LQSE----QVLEGAQKTLLLAN 1274
+LK + + +E ++ + KQL+E LQ E Q + QKT + +
Sbjct: 2777 ---NLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMD 2833
Query: 1275 EKVEEFTTFVKALAKELQ 1292
KV+E TT +K L + L+
Sbjct: 2834 TKVDELTTEIKELKETLE 2851
Score = 116 bits (291), Expect = 1e-25
Identities = 235/1287 (18%), Positives = 512/1287 (39%), Gaps = 134/1287 (10%)
Query: 141 TQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEE 200
T+ + + E E Q + K K Q + ++ E KQ++ + + E
Sbjct: 14 TRALQKIQELEGQLDKLKKEK-----QQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE 68
Query: 201 NAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLND 260
N L + LEK + S E++ + V +E Q K +E+ ++L RC ++
Sbjct: 69 NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK-RCK---SE 124
Query: 261 LEKLRK--QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
LE+ ++ Q A + +T KI T ++ S+Y + +K +L
Sbjct: 125 LERSQQAAQSADVSLNPCNTPQKIFT-----------TPLTPSQYYS-----GSKYEDLK 168
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESI 378
+K KE++E + L + A++A Q L M+ + + R+Q ++
Sbjct: 169 EK------YNKEVEERKRLEAEVKALQAKKAS--QTLPQATMNHRDIARHQA---SSSVF 217
Query: 379 SYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQ 438
S+Q+ H+ ++ S +R+ + EQE + LQ + +
Sbjct: 218 SWQQEKTPSHL---SSNSQRTPIRR---DFSASYFSGEQEVTPSRSTLQIGK-------R 264
Query: 439 ESDPDY--SAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKS 496
+++ + ++ PH L L+ +++I L+ +L+ +++ ++ + +
Sbjct: 265 DANSSFFDNSSSPH--LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQL 322
Query: 497 IMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELR 556
E KE + + R +++ + K E+K++ L + L + Q + R
Sbjct: 323 EKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESAR 382
Query: 557 -DAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNEL 615
+K KE+ + Q + + ++ E ++K Q+L+Q N
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQ-----ECIQMKARLTQELQQAK-----NMH 432
Query: 616 AYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQ-------ELNRCVAE-RREEQLFR 667
+ E +L K LE L+E K + + A Q EL R + E ++E L +
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
Query: 668 SGEDDEVKR----STPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKEND 723
S + + + KN K+ L Q+ E++ + S E R L+E K +EN
Sbjct: 493 SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQE--KINQQENS 550
Query: 724 FLKSLLKQQQEDTE-----------TREKELEQIIKGSKDVEKENTELQVKISELETEVT 772
LK D E RE +EQ+ EKE+ L + + E
Sbjct: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
Query: 773 SLRRQVAEANALRNENEELINPMEKSHQS----ADRAKSEMATMKVRSGRYDCKTTMTKV 828
L+ + + ++ENE+L+ ME ++ + ++ + T +++S Y+ + ++
Sbjct: 611 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 829 KFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIV 888
++N SV + H++ +V K + ++ + + S+ + + + + +
Sbjct: 671 D----RENLSVEIRNL---HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCL 723
Query: 889 ETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKK 948
+TSQ ED + + + ++ K+ L+ + ++ +D K+A T +
Sbjct: 724 KTSQLTGQVEDLEHKLQ---LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 949 NCKM-----QKSSHTAVPTRVNRE-------KYKNITAQKSSSNIILLRERI----ISLQ 992
+ Q + H + + + + A +S N +L+ R+ SL+
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
Query: 993 QQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKE 1052
Q + + +K E V+ E+ E L+ +Q+ + Q I KL D + +
Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 1053 DLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQS 1112
+ L LE+ + L + + IQ S + ++ +K+LQ + + E + S
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKS-NHLLEDSLKELQLLSETLSLEKKEMS 959
Query: 1113 SNVKTLK---FELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSE 1169
S + K EL + +KE++ +++ + ++ K F ++ E KS SE
Sbjct: 960 SIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSE-----SFANYID-EREKSISE 1013
Query: 1170 MLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTL 1229
+ ++ L + C + + L Q+ A ++ S+ E + + E + +L
Sbjct: 1014 LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ 1073
Query: 1230 LVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAK 1289
L ++ A ++ Q L L+ E V + + + + +K
Sbjct: 1074 LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIM 1133
Query: 1290 ELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNIS---RSDLEEILDTEDQ 1346
L+ + + +++++ +L + + + H+ Q L + + S R + + Q
Sbjct: 1134 TLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQ 1193
Query: 1347 VEIEKTKIDAENDKEWMLYIQKLLEGQ 1373
+++E +I ++ ++ ++ +L +
Sbjct: 1194 MDLEVKEISLDSYNAQLVQLEAMLRNK 1220
Score = 116 bits (290), Expect = 2e-25
Identities = 280/1374 (20%), Positives = 545/1374 (39%), Gaps = 204/1374 (14%)
Query: 104 LLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVL 163
L EE+ KE L Q +++ + + + + N + + + V ERE ++++ + +
Sbjct: 1135 LKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQM 1194
Query: 164 EILQVKDAKIQEFE----QRESVLKQE---INDLVKRKIAVDEENAFLRKEFSDLE-KKF 215
+ L+VK+ + + Q E++L+ + + + K K + E +R DLE
Sbjct: 1195 D-LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIR---GDLETSNL 1250
Query: 216 KD-KSQEIKDTKECVQNKEEQ---NRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
+D +SQEI K+C + EE+ + + +N L +N L +L K L
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEIL 1310
Query: 272 RKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ EKY ++ I A +++ K +++ N + L+ ++ + E
Sbjct: 1311 QAEKYELVTELNDSRSECITATRKMAEEVGKL-LNEVKILNDDSGLLHGELVEDIPGGEF 1369
Query: 332 QELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICF 391
E N S ++ + L + + + Q ++ + +S Q + LH
Sbjct: 1370 GEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQE----KFLSLQSEHKILH--- 1422
Query: 392 ETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQG-----APLPLPQESDPDYSA 446
+ ++ LQ + + EN L L+ QG L L + P S+
Sbjct: 1423 ----DQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSS 1478
Query: 447 Q-VPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKH 505
VP SLSSL ++ +E + ++N L +SAN+ + +S + ++
Sbjct: 1479 SCVPDSSSLSSLGDSSF-YRALLEQTGDMSLLSN--LEGAVSANQCSVDEVFCSSLQEEN 1535
Query: 506 ---KEPPVKRSRSLSPKSSFTD--SEELQKLRKA--------ERKIENLEKALQLKSQEN 552
KE P ++ + S + + L+KL + ++I+ LE+ L + QE
Sbjct: 1536 LTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQEL 1595
Query: 553 DELRDAHEKRKERLQMLQTNYRAVKE-----QLKQWEEGSGMTEIRKIKR-----ADPQQ 602
D LR + E+ Q T+ E + KQ E+ S E+ +++ +
Sbjct: 1596 DCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSL 1655
Query: 603 LRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELK---VHISIDKAAIQELN----- 654
L + DA+ + N+ I K + E + VH DK A Q+LN
Sbjct: 1656 LGIDTEDAI-------QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEK 1708
Query: 655 -----------RCVAERREEQLFRS-GED---------DEVKRSTPEK-------NGKEM 686
C E+ + + GED E+ S P +E
Sbjct: 1709 ITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQED 1768
Query: 687 LEQTLQKVTELENR----LKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKE 742
+ +V E N L E R RK++ L+ E L S L Q+ T+ +
Sbjct: 1769 IHNLQLRVKETSNENLRLLHVIEDRDRKVES----LLNEMKELDSKLHLQEVQLMTKIEA 1824
Query: 743 LEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSA 802
++ K +++KEN++L K+ + L ++V + L N + E+
Sbjct: 1825 CIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGL-NSDLEMHADKSSREDIG 1883
Query: 803 DRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSK 862
D + K R D + +++++ + A S+ L ++V+ L K
Sbjct: 1884 DNVAKVNDSWKERF--LDVENELSRIRSEKA----SIEHEALYLEADLEVVQTEKLCLEK 1937
Query: 863 DGW----------EDVSESSSD-----SEAQTSQTLGTIIVETSQKISPTEDGKDQKESD 907
D E++S +S+ E T T + + S+K+ + +S+
Sbjct: 1938 DNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 1997
Query: 908 ------PTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVP 961
E + E++QT + + KD H Q+K ++K S
Sbjct: 1998 CLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH--------LQEKLQSLEKDSQALSL 2049
Query: 962 TRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQ----NAKKTAELSVKEYKEVNE 1017
T+ E N AQ + +L++E SLQ + S N K E ++ E E
Sbjct: 2050 TKCELE---NQIAQLNKEKELLVKESE-SLQARLSESDYEKLNVSKALEAALVEKGEFAL 2105
Query: 1018 KL------LHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKE---DLLK-KLESSSEITSL 1067
+L +HQ + ++ + + +K L +A KE+E D LK K+E+ +
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQM 2165
Query: 1068 AEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEE 1127
+EEN ++ + + + E++ L+ +++ L ++ TL+ E +
Sbjct: 2166 SEENQELV--------ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTK 2217
Query: 1128 HIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSN 1187
I+E ++S +++ ++ + L+E+ + + E +K+ EMLQN K++
Sbjct: 2218 QIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCG 2277
Query: 1188 KKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISET---------- 1237
+ + + +Q L+ ++E+ Q +K + LE + K ++ ++ E+
Sbjct: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGR 2337
Query: 1238 -ESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVH 1296
E+ E+E A + Q + AL++E +G +TL K+E T ++ L+ DV
Sbjct: 2338 VENLERELEIARTNQ-EHAALEAEN-SKGEVETL---KAKIEGMTQSLRG----LELDVV 2388
Query: 1297 VVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIE 1350
+R + L T+ + + S L I S E IL ++Q +++
Sbjct: 2389 TIRSEKENL-----------TNELQKEQERISELEIINSSFENILQEKEQEKVQ 2431
Score = 114 bits (284), Expect = 9e-25
Identities = 253/1280 (19%), Positives = 504/1280 (39%), Gaps = 201/1280 (15%)
Query: 150 REKQKSEAKDRKVLEI----LQVKDAK------------IQEFEQRESVLKQEINDLVKR 193
+EK E ++RK LE LQ K A I + SV + +
Sbjct: 168 KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQ-QEKTPS 226
Query: 194 KIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQ-NKEEQNRLVIKNLEEENKKLST 252
++ + + +R++FS + QE+ ++ +Q K + N N +
Sbjct: 227 HLSSNSQRTPIRRDFS---ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHL---- 279
Query: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSN 312
L++L+ Q LR KI E L KE++ +K+ L LQL
Sbjct: 280 --------LDQLKAQNQELRN-------KINELELRLQGHEKEMKGQVNKFQELQLQLEK 324
Query: 313 KQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
+ ELI+K+ + R EL Y Q ST + L Q+L+ L D +N E
Sbjct: 325 AKVELIEKEKVLNKCRDELVRTTAQYDQAST---KYTALEQKLKKLTEDLSCQRQNAESA 381
Query: 373 HTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGA 432
S ++ E F+ S + ++S L + +Q + A+L ++LQ+++
Sbjct: 382 R----CSLEQKIKEKEKEFQEELSRQ---QRSFQTLDQECIQMK---ARLTQELQQAKNM 431
Query: 433 PLPLPQESDPDYSAQVPHRPSLSSL--------ETLMVSQ--KSEIEYLQEKLKIANEKL 482
L E D S + +L + SQ ++E+ E++K N L
Sbjct: 432 HNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLL 491
Query: 483 SENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLE 542
S ++ +R+ AE K+ + + +S++ + + ++ + LR + KI E
Sbjct: 492 K---SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
Query: 543 KALQLK---------SQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIR 593
+L L+ ++ D +D +KR+ ++ L K +E +
Sbjct: 549 NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS------KTEKESKALLSAL 602
Query: 594 KIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQ----KMNLEEELDELKVHISIDKAA 649
++K+ + ++L++E + + +K EN++L+ Q K NL+ +++ L+ + +
Sbjct: 603 ELKKKEYEELKEEKT-----LFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIK 657
Query: 650 IQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSR 709
E N V R+ E D S +N +L+ K E+E + ++ + +
Sbjct: 658 SHEYNERV---------RTLEMDRENLSVEIRNLHNVLD---SKSVEVETQKLAYMELQQ 705
Query: 710 KLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELET 769
K + ++K KE + + Q E E +L+ + D ++ +L + L
Sbjct: 706 KAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD 765
Query: 770 EVTSLRRQVAEANALRNENEE----LINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTM 825
+ S +A+ + NE+ + + H S E +M S R +C
Sbjct: 766 LLKS-----KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMP--SERSEC---- 814
Query: 826 TKVKFKAAKKNCSVGRHHT-VLNHSIKVMSNVFENLSKDGWE--DVSESSSDSEAQTSQT 882
+++ + KN ++ ++ L S++ + +L K E + ++ + Q
Sbjct: 815 -RLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 883 LGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKK 942
+ + ETSQ+IS + ED+ + +T ++ K + N K
Sbjct: 874 HQSFVAETSQRISKLQ-----------EDTSAHQNVVAETLSALENKEKE--LQLLNDKV 920
Query: 943 PTFQKKNCKMQKSSHTAVPTRVNREKYKNITA--QKSSSNIILLRER-IISLQQQNSVLQ 999
T Q + +++KS+H + + + +K S+II L +R I L Q+N L
Sbjct: 921 ETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL- 979
Query: 1000 NAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGL----RKEKEDLL 1055
KE+N L ++ Q+ ++ I + ++ L ++EK LL
Sbjct: 980 -------------KEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 1056 KKLES--------SSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEM------------- 1094
++ E S + + E+NS++ + TSL +R +LE
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL 1086
Query: 1095 ----------KQLQYKLKNATNEL-TKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDI 1143
+ L +L+ L ++ + N K E ++ I + E+ ++M++++
Sbjct: 1087 TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEV 1146
Query: 1144 TMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECS--------NKKVSIDSL 1195
E L K E SE ++N K+ ++ +C+ K++S+DS
Sbjct: 1147 NDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY 1206
Query: 1196 KQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQEL 1255
+L E Q+S E EK+ L+ L R S + ++++ L++
Sbjct: 1207 NAQLVQLEAMLRNKELKLQES--EKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDC 1264
Query: 1256 ALQSEQ-VLEGAQKTLLLANEKVEEFTTFVKALAK--ELQNDVHVVRRQIREL-KKMKKN 1311
+ +E+ + G + N+ + + K EL+ +++ + EL ++ +
Sbjct: 1265 EIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDS 1324
Query: 1312 RDACKTSTHKAQTLAASILN 1331
R C T+T K +LN
Sbjct: 1325 RSECITATRKMAEEVGKLLN 1344
Score = 111 bits (277), Expect = 6e-24
Identities = 291/1398 (20%), Positives = 543/1398 (38%), Gaps = 273/1398 (19%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
+ E A + Q ++E+ +EEL+ Q + Q + + Q+ + + + +
Sbjct: 377 NAESARCSLEQKIKEKEKEFQEELSRQQ----------RSFQTLDQECIQMKARLTQELQ 426
Query: 153 QKS------EAKDRKVLEILQVKDAKIQEFEQRESVLKQEI-------NDLVKRKIAVDE 199
Q +A+ K+ + Q + ++EF+Q+ +Q N+L + + +
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Query: 200 ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQN----------KEEQNRLVIKNLEE---- 245
EN L+ ++ E+K+ K+C+ K ++++L+E
Sbjct: 487 ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
Query: 246 -ENKKLSTRCTDLLNDLEK--------LRKQEAH-----------------------LRK 273
EN + + DLEK L+K+E H L+K
Sbjct: 547 QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKK 606
Query: 274 EKYSTDAKIKTF--------EDNLIEARKEVEVSQSKYNALSLQLSNKQTE-------LI 318
++Y + KT E L + E E QSK N L L +Q + +
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQ----AELIQQLQVLNMDTQKVLRNQ----- 369
+MD + E++ L N+ S Q EL Q+ + + QK + N
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTS 726
Query: 370 ------EDVH------TAESISYQKLYNELHICFET----TKSNEAMLRQSVTNLQDQ-- 411
ED+ + E + + Y +LH +E+ KS +A L VTN Q
Sbjct: 727 QLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL---VTNEDHQRS 783
Query: 412 LLQKEQE--------NAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVS 463
LL +Q+ N ++ S+ + L + P SA + +R + SLE + S
Sbjct: 784 LLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR--VDSLEFSLES 841
Query: 464 QKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFT 523
QK LQ K E + KG +++M AE H+ + S+ +S T
Sbjct: 842 QKQMNSDLQ--------KQCEELVQIKGEIEENLM-KAEQMHQSFVAETSQRISKLQEDT 892
Query: 524 DSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQW 583
+ + + + +EN EK LQL L D E + +Q L+ + +++ LK+
Sbjct: 893 SAHQ-NVVAETLSALENKEKELQL-------LNDKVETEQAEIQELKKSNHLLEDSLKEL 944
Query: 584 EEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHI 643
+ S + K + + L + + + + E K N L +KMNL ++ + +I
Sbjct: 945 QLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYI 1004
Query: 644 SIDKAAIQELN------RCVAERREEQLFRSGEDDEVK-RSTPEKNGKEMLEQTLQKVTE 696
+ +I EL+ + + +R E+ + ED K ++ EKN K LE L + T
Sbjct: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSK--LECLLNECTS 1062
Query: 697 L-ENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKEL-EQIIKGSKDVE 754
L ENR E+ + +++ + + F + + + ET ++ L ++ + +
Sbjct: 1063 LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSK 1122
Query: 755 KENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKV 814
E L+ +I L+ E ++++V N L ENE+L+ M+ H+ +SE V
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQKEV---NDLLQENEQLMKVMKTKHE-CQNLESEPIRNSV 1178
Query: 815 RSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSD 874
+ + K + K S+ ++ L ++ N L + SE +
Sbjct: 1179 KERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQE------SEKEKE 1232
Query: 875 SEAQTSQTL-GTIIVETSQKISPTE-DGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPK 932
QT+ G + Q + E G E D E+ G + T N
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEID-AEEKYISGPHELSTSQN------- 1284
Query: 933 DYFHDKNAKKPTFQKKN-----CKMQKSSHTAVPTRVNREKYKNITA-QKSSSNIILLRE 986
D H + + + T K N C++ ++ + T +N + + ITA +K + + L
Sbjct: 1285 DNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLN 1344
Query: 987 RIISLQQQNSVL------------------------------QNAKKTAELSVKE----Y 1012
+ L + +L N+ + LS KE +
Sbjct: 1345 EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHF 1404
Query: 1013 KEVNE---------KLLHQQ--QVSDQ--RFQTSRQTIKKLNLDLA-GLRKEKEDLLKKL 1058
E+ E K+LH Q Q+S + QT ++K NL L+ LR + DL+K++
Sbjct: 1405 AELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEM 1464
Query: 1059 ESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTL 1118
+ E + +S ++SL S A E T S + L
Sbjct: 1465 QLGLEEGLVPSLSSSCVPDSSSLSSLGDS------------SFYRALLEQTGDMSLLSNL 1512
Query: 1119 KFELLAKEEHIKEM------HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQ 1172
+ + A + + E+ E ++R E + +E+L+ +V +S + E ++
Sbjct: 1513 EGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKG-VEELESLCEVYRQSLEKLEEKME 1571
Query: 1173 N----LDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLT 1228
+ +K+++ L + S+++ +D L+++ + E Q++Q E+E K
Sbjct: 1572 SQGIMKNKEIQELEQLLSSERQELDCLRKQY---LSENEQWQQKLTSVTLEMESK----- 1623
Query: 1229 LLVSRISETESAMAEIETAASKQLQELALQS--------EQVLEGAQKTLLLANEKVEEF 1280
L + +TE E+E A QLQ L L S E ++G ++ ++ E E
Sbjct: 1624 -LAAEKKQTEQLSLELE-VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSET 1681
Query: 1281 TTFVKALAKELQNDVHVV 1298
T + ++DVH +
Sbjct: 1682 T------ERTPKHDVHQI 1693
Score = 106 bits (264), Expect = 2e-22
Identities = 157/733 (21%), Positives = 316/733 (43%), Gaps = 110/733 (15%)
Query: 92 ISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVERE 151
I ++E T ++L+ +L L E +A D+E + + + L + Q+ + + E+
Sbjct: 2248 IQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI-EKL 2306
Query: 152 KQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDL 211
+ + EA ++K L +LQ +++E E +LK + +L +R++ + N +E + L
Sbjct: 2307 RARLEADEKKQLCVLQ----QLKESEHHADLLKGRVENL-ERELEIARTN----QEHAAL 2357
Query: 212 EKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
E ++ K E ++ K E ++ LE + + + +L N+L+K
Sbjct: 2358 E------AENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQK-------- 2403
Query: 272 RKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+E+ S I + +N+++ +++ +V + ++ ++++ QT+L KEL
Sbjct: 2404 EQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML--QTQL-----------KEL 2450
Query: 332 QE-LQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHIC 390
E + L+ A++ L Q++ L ++ ++L+ ++
Sbjct: 2451 NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA------------------ 2492
Query: 391 FETTKSNEAMLRQSVTNL-------QDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPD 443
K+N +L+ SV L + +L +K++E ++LK ++Q+ + L Q
Sbjct: 2493 ----KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH 2548
Query: 444 YSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEG 503
Q+ +L L L V + +I+ LQ K + L S+ K + +T +
Sbjct: 2549 ---QLWKEQNLE-LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD- 2603
Query: 504 KHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRK 563
K SF ++K+ K K L++ + +Q+ EL++ K
Sbjct: 2604 ---------------KMSF-----VEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643
Query: 564 ERL----QMLQTNYRAVKEQLKQWE-EGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYF 618
RL Q+L ++ K+QLK+ E S + + D + E V E+A +
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD----QVEKEGKVREEIAEY 2699
Query: 619 KRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRST 678
+ E +K + LD K + + IQ + + E + E D +K S
Sbjct: 2700 QLRLHEA--EKKHQALLLDTNKQY----EVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 679 PEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTET 738
E N L+ T Q + EL+ K +LK+ N++ + L KQ +E+ E
Sbjct: 2754 EELNNS--LKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI 2811
Query: 739 REKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKS 798
+KEL Q+ + +++ +K T + K+ EL TE+ L+ + E +E + + S
Sbjct: 2812 LQKELSQL-QAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLIS 2870
Query: 799 HQSADRAKSEMAT 811
H+ ++AK + T
Sbjct: 2871 HEKLEKAKEMLET 2883
Score = 85.5 bits (210), Expect = 3e-16
Identities = 247/1297 (19%), Positives = 526/1297 (40%), Gaps = 170/1297 (13%)
Query: 197 VDEENAF---------LRKEFSDLEKKFKDKSQEIK---DTKECVQNKEEQNRLVIKNLE 244
+DE N++ ++ F++L++KF E K D + +K + + + +L+
Sbjct: 1384 LDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLK 1443
Query: 245 EENKKLSTRCTDLLNDLEK---LRKQEA---HLRKEKYSTDAKIKTFEDN-----LIEAR 293
EN LST + DL K L +E L + + + D+ L+E
Sbjct: 1444 AENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQT 1503
Query: 294 KEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKE-----------LQELQNLYKQNS 342
++ + + A+S + + L RKE L+ L +Y+Q+
Sbjct: 1504 GDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQS- 1562
Query: 343 THTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLR 402
+++L+ M++Q +++N+E + +S ++ EL + S +
Sbjct: 1563 ---------LEKLEE-KMESQGIMKNKEIQELEQLLSSER--QELDCLRKQYLSENEQWQ 1610
Query: 403 QSVTN--------LQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSL 454
Q +T+ L + Q EQ + +L+ + QG L D + R
Sbjct: 1611 QKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNES 1670
Query: 455 SSL------ETLMVSQKSEIEYL-----QEKLKIANEKLSENISANKGFSRKSIMTSAEG 503
+ ET + K ++ + Q+ L + EK++E A K S S +
Sbjct: 1671 CDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET-GAVKPTGECSGEQSPDT 1729
Query: 504 KHKEPPVKRSRSLSP---KSSFTDSEELQKLRKA--ERKIENLEKALQLKSQENDELRDA 558
++ P +++ S + SF+ L + + I NL+ ++ S EN L
Sbjct: 1730 NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHV 1789
Query: 559 HEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADP--QQLRQEDSDAVWNELA 616
E R +++ L + + +L +E MT+I + +L++E+SD + +L
Sbjct: 1790 IEDRDRKVESLLNEMKELDSKL-HLQEVQLMTKIEACIELEKIVGELKKENSD-LSEKLE 1847
Query: 617 YFKRENQELMIQKMNLEEELD-ELKVHISIDKAAIQELNRCVAERREEQLFRSGE-DDEV 674
YF ++QEL+ Q++ E L+ +L++H DK++ +++ VA+ + R + ++E+
Sbjct: 1848 YFSCDHQELL-QRVETSEGLNSDLEMHA--DKSSREDIGDNVAKVNDSWKERFLDVENEL 1904
Query: 675 KRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQE 734
R EK E + LE L+ + L++ N+ K L+ L
Sbjct: 1905 SRIRSEKASIE------HEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTS 1958
Query: 735 DTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINP 794
+ EL+ + K + +++ + +++ K ELE+ + + A A E EL+
Sbjct: 1959 ERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT 2018
Query: 795 MEKSHQSADRAKSEMATMKVRSGRYDCKT-TMTKVKFKAAKKNCSVGRHHTVLNHSIKVM 853
+ + K+ + K++S D + ++TK C + LN +++
Sbjct: 2019 LSSDVSELLKDKTHLQE-KLQSLEKDSQALSLTK---------CELENQIAQLNKEKELL 2068
Query: 854 SNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQ---KISPTEDGKDQKESDPTE 910
E+L +SES + + S+ L +VE + ++S T++ Q
Sbjct: 2069 VKESESLQAR----LSESDYE-KLNVSKALEAALVEKGEFALRLSSTQEEVHQLR----- 2118
Query: 911 DSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYK 970
+G E ++ + D K H K ++ + K + +++ E +
Sbjct: 2119 ----RGIEKLRVRIEAD---EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171
Query: 971 NITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRF 1030
+ +S + + +L+ Q + + K EL + + E L +Q+ +++
Sbjct: 2172 LVILDAENS-----KAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLT--KQIQEKQG 2224
Query: 1031 QTSRQTIKKLNLDLAGLRKEKE--DLLKKLESSSEITSLAEENSQVTFPRI-----QVTS 1083
Q S + KL L +EKE ++ K ES + + L + ++ Q
Sbjct: 2225 QLSE--LDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIM 2282
Query: 1084 LSPSRSMDLEMKQLQYKLKNATNELTK--QSSNVKTLKF--ELLAKEEHIKEMHEKISRM 1139
+ +S+D +++ +++L+N+ +L ++ K L +L E H + ++ +
Sbjct: 2283 KATEQSLDPPIEE-EHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENL 2341
Query: 1140 ERDITMKRHLIEDLKFR---QKVNLESNKS----FSEMLQNLDKKVKTLTEECSNKKVSI 1192
ER++ + R E K +E+ K+ ++ L+ L+ V T+ E N +
Sbjct: 2342 ERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNEL 2401
Query: 1193 DSLKQRLNVAVKEKSQYEQMYQKSKEEL----EKKDLKLTLLVSRISETESAMAEI---- 1244
++R++ S +E + Q+ ++E EK + +L +++ E +A +
Sbjct: 2402 QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Query: 1245 ------ETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVV 1298
E S Q++ L L+ Q+L+G + A + V L +E+++ +
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQGLDE----AKNNYIVLQSSVNGLIQEVEDGKQKL 2517
Query: 1299 RRQIRELKKMK-----KNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTK 1353
++ E+ ++K + + K S + + N+ +L L+ + QV ++
Sbjct: 2518 EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV-LQSKN 2576
Query: 1354 IDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINE 1390
++ E + K LE +L + +EK+N+
Sbjct: 2577 ASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Score = 55.5 bits (132), Expect = 4e-07
Identities = 130/649 (20%), Positives = 239/649 (36%), Gaps = 90/649 (13%)
Query: 763 KISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRY--- 819
KI ELE ++ L++ E + + + L ++K Q + K+E +K + R
Sbjct: 19 KIQELEGQLDKLKK---EKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
Query: 820 --DCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEA 877
+ T K+ + K V LN K + + + L + SE +A
Sbjct: 76 CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK----SELERSQQA 131
Query: 878 QTSQTLGTIIVETSQKISPTEDGKDQKESDPT-EDSQTQGKEIVQTYLNIDGKTPKDYFH 936
S + T QKI T Q S ED + + + V+ ++ +
Sbjct: 132 AQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKA--LQ 189
Query: 937 DKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIIS------ 990
K A + Q + H A + + ++ K + S+S +R +
Sbjct: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGE 249
Query: 991 --LQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLR 1048
+ S LQ K+ A S + + LL Q + +Q R I +L L L G
Sbjct: 250 QEVTPSRSTLQIGKRDANSSFFDNSS-SPHLLDQLKAQNQEL---RNKINELELRLQGHE 305
Query: 1049 KEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
KE + + K + L E ++V E+ + + L +EL
Sbjct: 306 KEMKGQVNKFQE----LQLQLEKAKV------------------ELIEKEKVLNKCRDEL 343
Query: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFS 1168
+ ++ + A E+ +K++ E +S ++ R +E QK+ E K F
Sbjct: 344 VRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE-----QKIK-EKEKEFQ 397
Query: 1169 EMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLT 1228
E L + +TL +EC K + +E Q + M+ + EL+K
Sbjct: 398 EELSRQQRSFQTLDQECIQMKARL----------TQELQQAKNMHNVLQAELDKLTSVKQ 447
Query: 1229 LLVSRISETESAMAEIETA-ASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL 1287
L + + E + + E A + Q++E L+ +E +K L E+ V L
Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRS--MEEMKKENNLLKSHSEQKAREVCHL 505
Query: 1288 AKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQV 1347
EL+N + + ++MK + +T Q E+I E+ +
Sbjct: 506 EAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQ--------------EKINQQENSL 551
Query: 1348 EIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKLVE 1396
+EK K+ + ++ Q LL+ + E +E++N+K E
Sbjct: 552 TLEKLKLAVADLEKQRDCSQDLLKKR--------EHHIEQLNDKLSKTE 592
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 141 bits (355), Expect = 5e-33
Identities = 245/1226 (19%), Positives = 513/1226 (41%), Gaps = 145/1226 (11%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 866
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 922
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 983 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 343 THTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTK----SNE 398
H + +EL +L+ Q++ + + + ++ + + +L K E
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 399 AMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458
L+ ++ L D++ QK N LK K++E +G L ++ D + +A+ L
Sbjct: 1090 EELQAALARLDDEIAQK---NNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 459 TLMVSQKSEIEYLQEKLKIANE---KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRS 515
+ + K+E+E + E K + ++ K K++ E + E V+ R
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KAL--DEETRSHEAQVQEMRQ 1199
Query: 516 LSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRA 575
++ +E+L++ ++A+ NL+K Q +EN +L + Q ++ +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKA---NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 576 VKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEE 635
++ Q+++ + E + + D Q + ++V L + + +L +L +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 636 LDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVT 695
L + + + + Q+LN R+ E+ S +D + ++N + + +++
Sbjct: 1317 LQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 696 ELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
+ + +L+ F L+EG K+ KE +++L +Q +E +K +EK
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKE---IENLTQQYEEKAAAYDK-----------LEK 1420
Query: 756 ENTELQVKISELETEVTSLRRQVAEANALRNENEELI----NPMEKSHQSADRAKSEMAT 811
LQ ++ +L ++ + R+ V+ + + ++L+ N K DRA++E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 812 MKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSES 871
+ ++ ++ + +A + + R + +L ++ + + SKD DV ++
Sbjct: 1481 KETKA------LSLARALEEALEAKEELERTNKMLKAEMEDLVS-----SKD---DVGKN 1526
Query: 872 SSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTP 931
+ E ++ + L T + E ++ ED E TED++ + L ++ +
Sbjct: 1527 VHELE-KSKRALETQMEEMKTQLEELED-----ELQATEDAKLR--------LEVNMQAL 1572
Query: 932 KDYFH-DKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIIS 990
K F D A+ ++K ++Q+ H + K + + A L++ +
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 991 LQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK----------L 1040
+ A K + K+ +L + D+ F T+++ KK L
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1041 NLDLAGLRK-------EKEDLLKKLESS-SEITSLAEENSQVTFPRIQVTSLSPSRSMDL 1092
DLA + EKE+L ++L SS S +L +E ++ Q+ ++
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752
Query: 1093 E-----MKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKR 1147
E +++ + + +NEL + S + + E KE+ K+ ME + K
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK- 1811
Query: 1148 HLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE----ECSNKKVSIDSLKQ---RLN 1200
F + L+ K+ L E E K+ + SLKQ +L
Sbjct: 1812 -------------------FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 1201 VAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQEL--ALQ 1258
+ + +M ++ KE+ EK + ++ L ++ E E I K +EL A +
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1912
Query: 1259 SEQVLEGAQKTLLLANEKVEEFTTFV 1284
S + + G + L + + T+FV
Sbjct: 1913 SNEAM-GREVNALKSKLRRGNETSFV 1937
Score = 104 bits (259), Expect = 7e-22
Identities = 162/846 (19%), Positives = 340/846 (40%), Gaps = 104/846 (12%)
Query: 556 RDAHEKRKERLQMLQTNYR--AVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWN 613
R A KR+++L ++ R A +L+ W+ T+++ + + Q+ E+ A +
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE---EEMQAKED 859
Query: 614 ELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDE 673
EL K Q+ + LE++ +L + +K +QE + E +L+ E+
Sbjct: 860 ELQKTKERQQKAENELKELEQKHSQL----TEEKNLLQEQLQA-----ETELYAEAEEMR 910
Query: 674 VKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKL----------MKEND 723
V+ + ++ +E+L E+E RL+ E R ++L+ KK+ ++E +
Sbjct: 911 VRLAAKKQELEEILH-------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 724 FLKSLLKQQQEDTETREKELEQIIKGSKD----VEKENTELQVKISELETEVTSLRRQVA 779
+ L+ ++ E + K+LE I D + KE L+ +IS+L T + +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 780 EANALRNENEELINPMEKSHQSADRAKSEMATMKVR---------SGRYDCKTTMTKVKF 830
L+N++E +I+ +E + ++++ E+ +K + D + + ++K
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 831 KAAKKNCSVGRHHTVLNHSIKVMSNVFENLSK-DGWEDVSESSSDSEAQTSQTLGTIIVE 889
+ AKK + L+ I +N + + + +G +S+ D +++ +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEG--HISDLQEDLDSERA--------- 1132
Query: 890 TSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKN 949
+ ++++ D E+ + E+ T +D + K ++ T KK
Sbjct: 1133 -------ARNKAEKQKRDLGEELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKA 1182
Query: 950 CKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSV 1009
+ SH A + QK + + L E++ ++ + L K+T E
Sbjct: 1183 LDEETRSHEAQVQEMR---------QKHAQAVEELTEQLEQFKRAKANLDKNKQTLE--- 1230
Query: 1010 KEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLK-KLESSSEITSLA 1068
+ N L + +V Q Q KKL + L+ + D + + E + ++ L
Sbjct: 1231 ----KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 1069 EENSQVTFPRIQVTSLSPSRSMDL-----EMKQLQYKLKNATNELTKQSSNVKTLKFELL 1123
E VT + + + D+ +++ Q L+ T + S+ ++ L+ E
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 1124 AKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE 1183
+ ++ + E E +ER I+ + D K + + + ++ E + K+++ LT+
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 1184 ECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKE---ELEKKDLKLTLLVSR------- 1233
+ K + D L++ N +E ++ LEKK K L++
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 1234 -ISETESAMAEIETAASKQLQ-----ELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL 1287
E + A AE +K L E AL++++ LE K L E + V
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 1288 AKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQV 1347
EL+ + Q+ E+K + + +T A+ + + E L D+
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 1348 EIEKTK 1353
EK +
Sbjct: 1587 NEEKRR 1592
Score = 98.6 bits (244), Expect = 4e-20
Identities = 213/1030 (20%), Positives = 413/1030 (40%), Gaps = 149/1030 (14%)
Query: 103 QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKV 162
+LLEE +S L LA ++E +L K + N + + L V + K E K R+
Sbjct: 1002 KLLEERISDLTTNLA---EEEEKAKNLTK---LKNKHESMISELEV---RLKKEEKSRQE 1052
Query: 163 LEILQVK-DAKIQEFEQRESVLKQEINDLVKRKIAVDEEN---AFLR------------K 206
LE L+ K + +F ++ + L+ +I +L K ++A EE A R K
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLN------D 260
+ +LE D +++ D++ +NK E+ + ++L EE + L T D L+ +
Sbjct: 1112 KIRELEGHISDLQEDL-DSERAARNKAEKQK---RDLGEELEALKTELEDTLDSTATQQE 1167
Query: 261 LEKLRKQEAHLRK-----EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQT 315
L R+QE + K E S +A+++ +A +E+ ++ L +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 316 ELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAEL-IQQLQVLNMDTQKVLRNQED-VH 373
L +++ D+ EL+ L KQ H ++ E +Q+LQ D ++ D VH
Sbjct: 1228 TLEKENADLA---GELRVLGQA-KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 374 TAESI--SYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQG 431
++ S + NE + A L + + Q+ L ++ ++ + KL++ +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 432 APLPLPQESDPDYSAQVPHRPSLSSLETLMVSQK-------SEIEYLQEKLKIANEKLSE 484
L + D + A+ +S+L + K S +E L+E K +++ E
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI-E 1402
Query: 485 NISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEE--LQKLRKAERKIENL- 541
N++ + K+ +A K ++ + + L D++ + L K +RK + L
Sbjct: 1403 NLTQQ--YEEKA---AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 542 --EKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRAD 599
EK + K + + +A + KE + RA++E L+ EE + K+ +A+
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLA--RALEEALEAKEE---LERTNKMLKAE 1512
Query: 600 PQQLRQEDSDAVWN--ELAYFKR----ENQELMIQKMNLEEEL---DELKVHISIDKAAI 650
+ L D N EL KR + +E+ Q LE+EL ++ K+ + ++ A+
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 651 QELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRK 710
+ + R+EQ +E KR +++ Q + TELE+ E++ R
Sbjct: 1573 KGQFERDLQARDEQ-------NEEKR-------RQLQRQLHEYETELED-----ERKQRA 1613
Query: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
L KK + + D + E + + IKG ++ K+ +LQ ++ + + E
Sbjct: 1614 LAAAAKKKL-------------EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 771 VTSLRRQVAEANALRNENEELINPMEKS--HQSADRAKSEMATMKVRSGRYDCKTTMTKV 828
+ R E A ENE+ +E D A +E A + + K
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---------QADLEKE 1711
Query: 829 KFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIV 888
+ + GR N +D + + E + + G +
Sbjct: 1712 ELAEELASSLSGR-----------------NALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 889 ETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKK 948
+ + T+ + TE S Q E + L K + H+ + K
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 949 NCKMQKSSHTAVPTRVNREKYKNITAQKS-SSNIILLRERIISLQQQNSVLQNAKKTAEL 1007
++ + +V +E + A KS L+E ++ ++ + + + K+ AE
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 1008 SVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLA-----GLRKEKEDLLKKLESSS 1062
K++ +L ++ S QR +R+ +++ LD A + +E L KL +
Sbjct: 1875 GNARVKQLKRQLEEAEEES-QRINANRRKLQR-ELDEATESNEAMGREVNALKSKLRRGN 1932
Query: 1063 EITSLAEENS 1072
E + + S
Sbjct: 1933 ETSFVPSRRS 1942
Score = 91.3 bits (225), Expect = 6e-18
Identities = 199/960 (20%), Positives = 375/960 (39%), Gaps = 142/960 (14%)
Query: 526 EELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKE------- 578
+ELQK ++ ++K EN K L+ Q++ +L + +E+LQ Y +E
Sbjct: 859 DELQKTKERQQKAENELKELE---QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 579 QLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKR--ENQELMIQKMNLEEEL 636
+ ++ EE E R + D Q Q + + ++ + E +E QK+ LE+
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975
Query: 637 DELKVHISIDKAAIQE--LNRCVAERR--EEQLFR-----SGEDDEVKRSTPEKNGKEML 687
E K+ D+ + + N+ ER+ EE++ + E+++ K T KN E +
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 688 EQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE-NDFLKSLLKQQQEDTETR------E 740
++ELE RLK EK ++L++ +KL + +DF + + Q + E + E
Sbjct: 1036 ------ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 741 KELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQ 800
+EL+ + D + KI ELE ++ L+ + A RN+ E+ Q
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---------Q 1140
Query: 801 SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENL 860
D + A D T +++ K ++ + V+ +
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--------------VTVLKKALDEE 1186
Query: 861 SKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIV 920
++ V E AQ + L + + + + + K E E++ G+
Sbjct: 1187 TRSHEAQVQEMRQ-KHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE--- 1239
Query: 921 QTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKN----ITAQ- 975
L + G+ ++ H K + Q+ K K +N +T
Sbjct: 1240 ---LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 976 -KSSSNIILLRERIISLQQQ----NSVLQNA---KKTAELSVKEYKEVNEKLLHQQQVSD 1027
++ I L + + SL Q +LQ K +++ +E L Q
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 1028 QRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPS 1087
+ Q + I LN+ L+ +K+ +D +E+ E ++ + + + + +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 1088 RSMDLEMKQLQYKLKNATNELTKQSSNVKTL-----KFE-LLAKEEHIKEMH-EKISRME 1140
+ ++ +LQ +L + +L Q V L KF+ LLA+E++I + ++ R E
Sbjct: 1417 K-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 1141 RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLN 1200
+ K L + LE+ E L+ +K +K E+ + K D + + ++
Sbjct: 1476 AEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDLVSSK---DDVGKNVH 1528
Query: 1201 VAVKEKSQYEQMYQKSKEELEK--------KDLKLTL------LVSRISETESAMAEIET 1246
K K E ++ K +LE+ +D KL L L + A E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 1247 AASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQ----- 1301
+QLQ + E LE +K LA ++ +K L ELQ D + R+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQ 1646
Query: 1302 -----------IRELKKMKKNRD----ACKTSTHKAQTLAASILNISRSDLEEILDTEDQ 1346
REL+ + +RD K + KA++L A ++ + + DL Q
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARKQ 1705
Query: 1347 VEIEKTKIDAENDKEWMLYIQKLLEGQ--LPFASYLLEAVLEKINEKKKLVEGYFTIMKD 1404
++EK ++ E + L G+ L LEA + ++ E+ + +G M D
Sbjct: 1706 ADLEKEELAEE--------LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Score = 85.9 bits (211), Expect = 3e-16
Identities = 152/743 (20%), Positives = 311/743 (41%), Gaps = 91/743 (12%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E + L +++ Q + E V + + L + V+ + + + E + +
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI--- 222
L V K+++ E+ + L+ ++++ ++ K ++ + L + SD +KK +D + +
Sbjct: 1332 LNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 223 --------KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K+ + Q EE+ K LE+ +L DL+ DL+ R+ ++L K+
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 275 KYSTD---AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ D A+ K + R E + +L L+ E ++ ++ K L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 332 Q-ELQNLYKQN-----STHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYN 385
+ E+++L + H ++++ + Q+ M TQ L ED ++ KL
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ--LEELED--ELQATEDAKLRL 1565
Query: 386 ELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYS 445
E+++ +A+ Q +LQ + Q E++ +L+ +L E + L E
Sbjct: 1566 EVNM--------QALKGQFERDLQARDEQNEEKRRQLQRQLHEYE---TELEDERKQRAL 1614
Query: 446 AQVPHRPSLSSLETLMVSQKSEIEYLQEKLKI-----ANEKLSENISANKGFSRKSIMTS 500
A + L+ L + S I+ +E +K A K + + SR I +
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 501 AEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHE 560
A+ K+ + + + +E +K +A+ + E L + L + L+D E
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARK--QADLEKEELAEELASSLSGRNALQD--E 1730
Query: 561 KRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQ------QLRQEDSDAVWNE 614
KR+ L+ ++E+L++ E+G+ ++++A Q +L E S A NE
Sbjct: 1731 KRR-----LEARIAQLEEELEE-EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 615 LAYFKRENQELMIQKMNLEEELDELKVHI-SIDKAAIQELNRCVAERREEQLFRSGEDDE 673
A Q+L Q L +L E++ + S K+ I L +A+ EEQ+ + + +
Sbjct: 1785 SA-----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQ 1838
Query: 674 VKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQ 733
+ ++ K++ E LQ +E+ K E+ + ++GN ++ KQ +
Sbjct: 1839 AATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNARV-----------KQLK 1883
Query: 734 EDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELIN 793
E E+E ++I + +++E E + EV +L+ + LR NE
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK------SKLRRGNETSFV 1937
Query: 794 PMEKSH-----QSADRAKSEMAT 811
P +S ++AD ++ E T
Sbjct: 1938 PSRRSGGRRVIENADGSEEETDT 1960
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 141 bits (355), Expect = 5e-33
Identities = 245/1226 (19%), Positives = 513/1226 (41%), Gaps = 145/1226 (11%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 873
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 929
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 990 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 343 THTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTK----SNE 398
H + +EL +L+ Q++ + + + ++ + + +L K E
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 399 AMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458
L+ ++ L D++ QK N LK K++E +G L ++ D + +A+ L
Sbjct: 1097 EELQAALARLDDEIAQK---NNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 459 TLMVSQKSEIEYLQEKLKIANE---KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRS 515
+ + K+E+E + E K + ++ K K++ E + E V+ R
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KAL--DEETRSHEAQVQEMRQ 1206
Query: 516 LSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRA 575
++ +E+L++ ++A+ NL+K Q +EN +L + Q ++ +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKA---NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 576 VKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEE 635
++ Q+++ + E + + D Q + ++V L + + +L +L +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 636 LDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVT 695
L + + + + Q+LN R+ E+ S +D + ++N + + +++
Sbjct: 1324 LQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 696 ELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
+ + +L+ F L+EG K+ KE +++L +Q +E +K +EK
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKE---IENLTQQYEEKAAAYDK-----------LEK 1427
Query: 756 ENTELQVKISELETEVTSLRRQVAEANALRNENEELI----NPMEKSHQSADRAKSEMAT 811
LQ ++ +L ++ + R+ V+ + + ++L+ N K DRA++E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 812 MKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSES 871
+ ++ ++ + +A + + R + +L ++ + + SKD DV ++
Sbjct: 1488 KETKA------LSLARALEEALEAKEELERTNKMLKAEMEDLVS-----SKD---DVGKN 1533
Query: 872 SSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTP 931
+ E ++ + L T + E ++ ED E TED++ + L ++ +
Sbjct: 1534 VHELE-KSKRALETQMEEMKTQLEELED-----ELQATEDAKLR--------LEVNMQAL 1579
Query: 932 KDYFH-DKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIIS 990
K F D A+ ++K ++Q+ H + K + + A L++ +
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 991 LQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK----------L 1040
+ A K + K+ +L + D+ F T+++ KK L
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1041 NLDLAGLRK-------EKEDLLKKLESS-SEITSLAEENSQVTFPRIQVTSLSPSRSMDL 1092
DLA + EKE+L ++L SS S +L +E ++ Q+ ++
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 1093 E-----MKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKR 1147
E +++ + + +NEL + S + + E KE+ K+ ME + K
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK- 1818
Query: 1148 HLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE----ECSNKKVSIDSLKQ---RLN 1200
F + L+ K+ L E E K+ + SLKQ +L
Sbjct: 1819 -------------------FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 1201 VAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQEL--ALQ 1258
+ + +M ++ KE+ EK + ++ L ++ E E I K +EL A +
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATE 1919
Query: 1259 SEQVLEGAQKTLLLANEKVEEFTTFV 1284
S + + G + L + + T+FV
Sbjct: 1920 SNEAM-GREVNALKSKLRRGNETSFV 1944
Score = 104 bits (259), Expect = 7e-22
Identities = 162/846 (19%), Positives = 340/846 (40%), Gaps = 104/846 (12%)
Query: 556 RDAHEKRKERLQMLQTNYR--AVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWN 613
R A KR+++L ++ R A +L+ W+ T+++ + + Q+ E+ A +
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE---EEMQAKED 866
Query: 614 ELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDE 673
EL K Q+ + LE++ +L + +K +QE + E +L+ E+
Sbjct: 867 ELQKTKERQQKAENELKELEQKHSQL----TEEKNLLQEQLQA-----ETELYAEAEEMR 917
Query: 674 VKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKL----------MKEND 723
V+ + ++ +E+L E+E RL+ E R ++L+ KK+ ++E +
Sbjct: 918 VRLAAKKQELEEILH-------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 724 FLKSLLKQQQEDTETREKELEQIIKGSKD----VEKENTELQVKISELETEVTSLRRQVA 779
+ L+ ++ E + K+LE I D + KE L+ +IS+L T + +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 780 EANALRNENEELINPMEKSHQSADRAKSEMATMKVR---------SGRYDCKTTMTKVKF 830
L+N++E +I+ +E + ++++ E+ +K + D + + ++K
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 831 KAAKKNCSVGRHHTVLNHSIKVMSNVFENLSK-DGWEDVSESSSDSEAQTSQTLGTIIVE 889
+ AKK + L+ I +N + + + +G +S+ D +++ +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEG--HISDLQEDLDSERA--------- 1139
Query: 890 TSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKN 949
+ ++++ D E+ + E+ T +D + K ++ T KK
Sbjct: 1140 -------ARNKAEKQKRDLGEELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKA 1189
Query: 950 CKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSV 1009
+ SH A + QK + + L E++ ++ + L K+T E
Sbjct: 1190 LDEETRSHEAQVQEMR---------QKHAQAVEELTEQLEQFKRAKANLDKNKQTLE--- 1237
Query: 1010 KEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLK-KLESSSEITSLA 1068
+ N L + +V Q Q KKL + L+ + D + + E + ++ L
Sbjct: 1238 ----KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 1069 EENSQVTFPRIQVTSLSPSRSMDL-----EMKQLQYKLKNATNELTKQSSNVKTLKFELL 1123
E VT + + + D+ +++ Q L+ T + S+ ++ L+ E
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 1124 AKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE 1183
+ ++ + E E +ER I+ + D K + + + ++ E + K+++ LT+
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 1184 ECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKE---ELEKKDLKLTLLVSR------- 1233
+ K + D L++ N +E ++ LEKK K L++
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 1234 -ISETESAMAEIETAASKQLQ-----ELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL 1287
E + A AE +K L E AL++++ LE K L E + V
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 1288 AKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQV 1347
EL+ + Q+ E+K + + +T A+ + + E L D+
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 1348 EIEKTK 1353
EK +
Sbjct: 1594 NEEKRR 1599
Score = 98.6 bits (244), Expect = 4e-20
Identities = 213/1030 (20%), Positives = 413/1030 (40%), Gaps = 149/1030 (14%)
Query: 103 QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKV 162
+LLEE +S L LA ++E +L K + N + + L V + K E K R+
Sbjct: 1009 KLLEERISDLTTNLA---EEEEKAKNLTK---LKNKHESMISELEV---RLKKEEKSRQE 1059
Query: 163 LEILQVK-DAKIQEFEQRESVLKQEINDLVKRKIAVDEEN---AFLR------------K 206
LE L+ K + +F ++ + L+ +I +L K ++A EE A R K
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLN------D 260
+ +LE D +++ D++ +NK E+ + ++L EE + L T D L+ +
Sbjct: 1119 KIRELEGHISDLQEDL-DSERAARNKAEKQK---RDLGEELEALKTELEDTLDSTATQQE 1174
Query: 261 LEKLRKQEAHLRK-----EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQT 315
L R+QE + K E S +A+++ +A +E+ ++ L +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 316 ELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAEL-IQQLQVLNMDTQKVLRNQED-VH 373
L +++ D+ EL+ L KQ H ++ E +Q+LQ D ++ D VH
Sbjct: 1235 TLEKENADLA---GELRVLGQA-KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 374 TAESI--SYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQG 431
++ S + NE + A L + + Q+ L ++ ++ + KL++ +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 432 APLPLPQESDPDYSAQVPHRPSLSSLETLMVSQK-------SEIEYLQEKLKIANEKLSE 484
L + D + A+ +S+L + K S +E L+E K +++ E
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI-E 1409
Query: 485 NISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEE--LQKLRKAERKIENL- 541
N++ + K+ +A K ++ + + L D++ + L K +RK + L
Sbjct: 1410 NLTQQ--YEEKA---AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 542 --EKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRAD 599
EK + K + + +A + KE + RA++E L+ EE + K+ +A+
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLA--RALEEALEAKEE---LERTNKMLKAE 1519
Query: 600 PQQLRQEDSDAVWN--ELAYFKR----ENQELMIQKMNLEEEL---DELKVHISIDKAAI 650
+ L D N EL KR + +E+ Q LE+EL ++ K+ + ++ A+
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 651 QELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRK 710
+ + R+EQ +E KR +++ Q + TELE+ E++ R
Sbjct: 1580 KGQFERDLQARDEQ-------NEEKR-------RQLQRQLHEYETELED-----ERKQRA 1620
Query: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
L KK + + D + E + + IKG ++ K+ +LQ ++ + + E
Sbjct: 1621 LAAAAKKKL-------------EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 771 VTSLRRQVAEANALRNENEELINPMEKS--HQSADRAKSEMATMKVRSGRYDCKTTMTKV 828
+ R E A ENE+ +E D A +E A + + K
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---------QADLEKE 1718
Query: 829 KFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIV 888
+ + GR N +D + + E + + G +
Sbjct: 1719 ELAEELASSLSGR-----------------NALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 889 ETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKK 948
+ + T+ + TE S Q E + L K + H+ + K
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 949 NCKMQKSSHTAVPTRVNREKYKNITAQKS-SSNIILLRERIISLQQQNSVLQNAKKTAEL 1007
++ + +V +E + A KS L+E ++ ++ + + + K+ AE
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 1008 SVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLA-----GLRKEKEDLLKKLESSS 1062
K++ +L ++ S QR +R+ +++ LD A + +E L KL +
Sbjct: 1882 GNARVKQLKRQLEEAEEES-QRINANRRKLQR-ELDEATESNEAMGREVNALKSKLRRGN 1939
Query: 1063 EITSLAEENS 1072
E + + S
Sbjct: 1940 ETSFVPSRRS 1949
Score = 91.3 bits (225), Expect = 6e-18
Identities = 199/960 (20%), Positives = 375/960 (39%), Gaps = 142/960 (14%)
Query: 526 EELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKE------- 578
+ELQK ++ ++K EN K L+ Q++ +L + +E+LQ Y +E
Sbjct: 866 DELQKTKERQQKAENELKELE---QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 579 QLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKR--ENQELMIQKMNLEEEL 636
+ ++ EE E R + D Q Q + + ++ + E +E QK+ LE+
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982
Query: 637 DELKVHISIDKAAIQE--LNRCVAERR--EEQLFR-----SGEDDEVKRSTPEKNGKEML 687
E K+ D+ + + N+ ER+ EE++ + E+++ K T KN E +
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 688 EQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE-NDFLKSLLKQQQEDTETR------E 740
++ELE RLK EK ++L++ +KL + +DF + + Q + E + E
Sbjct: 1043 ------ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 741 KELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQ 800
+EL+ + D + KI ELE ++ L+ + A RN+ E+ Q
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---------Q 1147
Query: 801 SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENL 860
D + A D T +++ K ++ + V+ +
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--------------VTVLKKALDEE 1193
Query: 861 SKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIV 920
++ V E AQ + L + + + + + K E E++ G+
Sbjct: 1194 TRSHEAQVQEMRQ-KHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE--- 1246
Query: 921 QTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKN----ITAQ- 975
L + G+ ++ H K + Q+ K K +N +T
Sbjct: 1247 ---LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 976 -KSSSNIILLRERIISLQQQ----NSVLQNA---KKTAELSVKEYKEVNEKLLHQQQVSD 1027
++ I L + + SL Q +LQ K +++ +E L Q
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 1028 QRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPS 1087
+ Q + I LN+ L+ +K+ +D +E+ E ++ + + + + +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 1088 RSMDLEMKQLQYKLKNATNELTKQSSNVKTL-----KFE-LLAKEEHIKEMH-EKISRME 1140
+ ++ +LQ +L + +L Q V L KF+ LLA+E++I + ++ R E
Sbjct: 1424 K-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 1141 RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLN 1200
+ K L + LE+ E L+ +K +K E+ + K D + + ++
Sbjct: 1483 AEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDLVSSK---DDVGKNVH 1535
Query: 1201 VAVKEKSQYEQMYQKSKEELEK--------KDLKLTL------LVSRISETESAMAEIET 1246
K K E ++ K +LE+ +D KL L L + A E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 1247 AASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQ----- 1301
+QLQ + E LE +K LA ++ +K L ELQ D + R+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQ 1653
Query: 1302 -----------IRELKKMKKNRD----ACKTSTHKAQTLAASILNISRSDLEEILDTEDQ 1346
REL+ + +RD K + KA++L A ++ + + DL Q
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARKQ 1712
Query: 1347 VEIEKTKIDAENDKEWMLYIQKLLEGQ--LPFASYLLEAVLEKINEKKKLVEGYFTIMKD 1404
++EK ++ E + L G+ L LEA + ++ E+ + +G M D
Sbjct: 1713 ADLEKEELAEE--------LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Score = 85.9 bits (211), Expect = 3e-16
Identities = 152/743 (20%), Positives = 311/743 (41%), Gaps = 91/743 (12%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E + L +++ Q + E V + + L + V+ + + + E + +
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI--- 222
L V K+++ E+ + L+ ++++ ++ K ++ + L + SD +KK +D + +
Sbjct: 1339 LNVS-TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 223 --------KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE 274
K+ + Q EE+ K LE+ +L DL+ DL+ R+ ++L K+
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDK-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 275 KYSTD---AKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ D A+ K + R E + +L L+ E ++ ++ K L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 332 Q-ELQNLYKQN-----STHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYN 385
+ E+++L + H ++++ + Q+ M TQ L ED ++ KL
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ--LEELED--ELQATEDAKLRL 1572
Query: 386 ELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYS 445
E+++ +A+ Q +LQ + Q E++ +L+ +L E + L E
Sbjct: 1573 EVNM--------QALKGQFERDLQARDEQNEEKRRQLQRQLHEYE---TELEDERKQRAL 1621
Query: 446 AQVPHRPSLSSLETLMVSQKSEIEYLQEKLKI-----ANEKLSENISANKGFSRKSIMTS 500
A + L+ L + S I+ +E +K A K + + SR I +
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 501 AEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHE 560
A+ K+ + + + +E +K +A+ + E L + L + L+D E
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARK--QADLEKEELAEELASSLSGRNALQD--E 1737
Query: 561 KRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQ------QLRQEDSDAVWNE 614
KR+ L+ ++E+L++ E+G+ ++++A Q +L E S A NE
Sbjct: 1738 KRR-----LEARIAQLEEELEE-EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 615 LAYFKRENQELMIQKMNLEEELDELKVHI-SIDKAAIQELNRCVAERREEQLFRSGEDDE 673
A Q+L Q L +L E++ + S K+ I L +A+ EEQ+ + + +
Sbjct: 1792 SA-----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL-EEQVEQEAREKQ 1845
Query: 674 VKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQ 733
+ ++ K++ E LQ +E+ K E+ + ++GN ++ KQ +
Sbjct: 1846 AATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNARV-----------KQLK 1890
Query: 734 EDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELIN 793
E E+E ++I + +++E E + EV +L+ + LR NE
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK------SKLRRGNETSFV 1944
Query: 794 PMEKSH-----QSADRAKSEMAT 811
P +S ++AD ++ E T
Sbjct: 1945 PSRRSGGRRVIENADGSEEETDT 1967
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 141 bits (355), Expect = 5e-33
Identities = 222/1174 (18%), Positives = 483/1174 (41%), Gaps = 150/1174 (12%)
Query: 149 EREKQKSEAKD--RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ +K + L +AK +E E++ L +E NDL ++ V E L
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL---QLQVQSEADSLAD 903
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
E+ K+K Q KE + EE+ + L + +KL C++L D++ L
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEE-INAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
A + KEK++T+ K+K + + A + +++ +LQ +++QT
Sbjct: 963 TLAKVEKEKHATENKVKNLTEEM--AGLDETIAKLSKEKKALQETHQQT----------- 1009
Query: 327 VRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNE 386
L +LQ + + T + +L QQ+ L ++ + + D+ A+ +KL +
Sbjct: 1010 ----LDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAK----RKLEGD 1061
Query: 387 LHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSA 446
L + E+T E +Q L ++L +KE E + L K+++ Q + L Q+ + A
Sbjct: 1062 LKLAQESTMDMENDKQQ----LDEKLEKKEFEISNLISKIEDEQAVEIQL-QKKIKELQA 1116
Query: 447 QV--------PHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANK----GFSR 494
++ R S + E E+E + E+L+ A S + NK F +
Sbjct: 1117 RIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQK 1176
Query: 495 KSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDE 554
E V R S E++ L++ ++K+E + L++++ +
Sbjct: 1177 LRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSS 1236
Query: 555 LRDAHEKRKERLQMLQTNYRAVKEQLKQWEEG-----SGMTEIR-KIKRADPQQLRQ-ED 607
+A K K L+ + + +LK EE + +T R +++ + RQ ++
Sbjct: 1237 NAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE 1296
Query: 608 SDAVWNELAYFKR-ENQELMIQKMNLEEE-----------------LDELKVHISIDKAA 649
DA+ ++L+ K+ Q++ K LEEE D L+ ++
Sbjct: 1297 KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEG 1356
Query: 650 IQELNRCVAERREE--QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKR 707
EL R +++ E Q E D ++R+ + K+ L Q LQ E E +++ +
Sbjct: 1357 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ---EAEEHVEAVNAK 1413
Query: 708 SRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISEL 767
L++ ++L E + L +++ +K+ K + +++ E Q ++
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473
Query: 768 ETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTK 827
+ E SL ++ + + E+ + + + + +++ + S++ G+ + + K
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHE--LEK 1531
Query: 828 VKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTII 887
+K + ++ C + + + E E + L +
Sbjct: 1532 IKKQVEQEKCEI-------------------QAALEEAEASLEHEEGKILRIQLELNQVK 1572
Query: 888 VETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQK 947
E +KI+ ++ E D + + T+ E +Q+ L+ + ++ D K + +
Sbjct: 1573 SEVDRKIAEKDE-----EIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNE 1627
Query: 948 KNCKMQKSSHTAVPTRVNREKYKNI------------TAQKSSSNIILLRERIISLQQQN 995
++ ++ A + N + I Q+ + + ER +L Q
Sbjct: 1628 MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1687
Query: 996 -----SVLQNAKKTAELSVKEYKEVNEK--LLHQQQVSDQRFQTSRQTIKKLNLDLAGLR 1048
+ L+ +++ +++ +E + +E+ LLH Q S T KKL D++ L+
Sbjct: 1688 IEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTS------LINTKKKLENDVSQLQ 1741
Query: 1049 KEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNEL 1108
E E+++++ ++ E + +T + L + +++++ L+ +L
Sbjct: 1742 SEVEEVIQESRNAEE-----KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1796
Query: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFS 1168
+ + L +K ++I ++E + R L +++ QK N E+ K
Sbjct: 1797 QHRLDEAEQLA---------LKGGKKQIQKLEARV---RELEGEVENEQKRNAEAVKG-- 1842
Query: 1169 EMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLT 1228
L+ +++VK LT + + ++ L+ ++ + Y++ ++++E+ K
Sbjct: 1843 --LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFR 1900
Query: 1229 LLVSRISETESAMAEIETAASKQLQELALQSEQV 1262
L + E E E A Q+ +L ++S +V
Sbjct: 1901 KLQHELEEAE----ERADIAESQVNKLRVKSREV 1930
Score = 123 bits (308), Expect = 1e-27
Identities = 207/963 (21%), Positives = 400/963 (41%), Gaps = 126/963 (13%)
Query: 492 FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKA---LQLK 548
F K ++ SAE + KE + K SE K ++ E K+ L K LQL+
Sbjct: 837 FKIKPLLKSAETE-KEMATMKEEFQKTKDELAKSEA--KRKELEEKMVTLLKEKNDLQLQ 893
Query: 549 SQ-ENDELRDAHEKRKERLQ---MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
Q E D L DA E+ ++ ++ L+ + V E+ ++ EE + +K K D
Sbjct: 894 VQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSEL 953
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEE---LDELKVHISIDKAAIQELNRCVAERR 661
++D D + LA ++E + NL EE LDE +S +K A+QE ++ +
Sbjct: 954 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ E+D+V T K E L+ E E +L+ +R+++ EG+ KL +E
Sbjct: 1014 Q------AEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1067
Query: 722 NDFLKSLLKQQ-QEDTETREKELEQIIKGSKD-------VEKENTELQVKISELETEVTS 773
+ KQQ E E +E E+ +I +D ++K+ ELQ +I EL E+ +
Sbjct: 1068 STMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEA 1127
Query: 774 LRRQVAEANALRNE-NEELINPMEKSHQSADRAKSEMATMKVRSGRYD-CKTTMTKVKFK 831
R A+A R++ + EL E+ ++ +++ K R + + + + +
Sbjct: 1128 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQ 1187
Query: 832 AAKKNCSVGRHHT----VLNHSIKVMSNVFENLSKDGWE---DVSESSSDSEAQTSQTLG 884
++ + H L I + V + L K+ E + + SS++EA S+ G
Sbjct: 1188 HEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEA-ISKAKG 1246
Query: 885 TI------IVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDK 938
+ + + ++ E+ + + +D T E + +D K +
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSR 1306
Query: 939 NAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITA---QKSSSNIILLRERIISLQQQN 995
+ + T Q + K Q T K KN A Q S + LLRE+ Q+
Sbjct: 1307 SKQASTQQIEELKHQLEEET---------KAKNALAHALQSSRHDCDLLREQYEEEQEGK 1357
Query: 996 SVLQNAKKTAELSVKEYK--------EVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGL 1047
+ LQ A A V +++ + E+L ++ QR Q + + ++ +N A L
Sbjct: 1358 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 1048 RKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNE 1107
K K+ +L++ E L E S + R+ D + + + K + E
Sbjct: 1418 EKTKQ----RLQNEVEDLMLDVERSNAACAALD----KKQRNFDKVLSEWKQKYEETQAE 1469
Query: 1108 LTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSF 1167
L ++L EL + +E +++ + R+ NK
Sbjct: 1470 LEASQKESRSLSTELFKVKNVYEESLDQLETLRRE---------------------NK-- 1506
Query: 1168 SEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKL 1227
NL +++ LTE+ + I L++ +EK + + ++++ LE ++ K+
Sbjct: 1507 -----NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561
Query: 1228 TLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL 1287
+ +++ +S + +++ +L +V+E Q TL + ++ ++ +
Sbjct: 1562 LRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTL---DAEIRSRNDALR-V 1617
Query: 1288 AKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEIL----DT 1343
K+++ D++ + Q+ NR A ++ + T IL ++ L++ L D
Sbjct: 1618 KKKMEGDLNEMEIQLNH-----ANRLAAESLRNYRNT--QGILKETQLHLDDALRGQEDL 1670
Query: 1344 EDQVEIEKTK---IDAENDKEWMLYIQ-----KLLEGQLPFASYLLEAV----LEKINEK 1391
++Q+ I + + + AE ++ W Q K+ E +L AS ++ + IN K
Sbjct: 1671 KEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK 1730
Query: 1392 KKL 1394
KKL
Sbjct: 1731 KKL 1733
Score = 123 bits (308), Expect = 1e-27
Identities = 226/1199 (18%), Positives = 496/1199 (41%), Gaps = 223/1199 (18%)
Query: 87 RRLEGISVEEAMVTRTQLLEEELSSLKEE-------LALCQADKEFVWSLWKRLQVTNPD 139
R E + + + + LE+E S LK++ LA + +K + K L
Sbjct: 928 RAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 987
Query: 140 LTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDE 199
L + ++ + +EK+ + ++ L+ LQ ++ K+ + ++ L+Q+++DL + ++++
Sbjct: 988 LDETIAKL-SKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDL---EGSLEQ 1043
Query: 200 ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLN 259
E +K DLE+ + ++K +E + E + + + LE++ ++S +L++
Sbjct: 1044 E----KKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEIS----NLIS 1095
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQ 319
+E + E L+K KIK + + E +E+E ++ S + E +
Sbjct: 1096 KIEDEQAVEIQLQK-------KIKELQARIEELGEEIEAERA---------SRAKAEKQR 1139
Query: 320 KDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESIS 379
D+ +EL+E+ ++ T+ Q EL ++ +
Sbjct: 1140 SDLS-----RELEEISERLEEAGGATSAQVELNKKREA---------------------E 1173
Query: 380 YQKLYNELHICFETTKSNEAM---LRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPL 436
+QKL +L E T +EAM LR+ + +L ++ ++K+KL++ + L
Sbjct: 1174 FQKLRRDLE---EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKS---EL 1227
Query: 437 PQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKS 496
E+D S + +LE + S + ++ L+ K + ++L +++A + +
Sbjct: 1228 KMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTK-EEEQQRLINDLTAQRARLQTE 1286
Query: 497 IMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIEN-LEKALQLKSQENDEL 555
+ ++ + S S ++S EEL+ + E K +N L ALQ + D L
Sbjct: 1287 AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLL 1346
Query: 556 RDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNEL 615
R+ +E+ +E LQ ++ QW + ++DA+
Sbjct: 1347 REQYEEEQEGKAELQRALSKANSEVAQWR-------------------TKYETDAI---- 1383
Query: 616 AYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDD--- 672
+ +EL K L + L E + H+ A +C + + +Q ++ +D
Sbjct: 1384 ----QRTEELEEAKKKLAQRLQEAEEHVEAVNA------KCASLEKTKQRLQNEVEDLML 1433
Query: 673 EVKRST--------PEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDF 724
+V+RS ++N ++L + QK E + L++ +K SR L + +L K
Sbjct: 1434 DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL---STELFK---- 1486
Query: 725 LKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANAL 784
+K++ ++ + ET + +EN LQ +IS+L ++ +Q+ E +
Sbjct: 1487 VKNVYEESLDQLET--------------LRRENKNLQQEISDLTEQIAEGGKQIHELEKI 1532
Query: 785 RNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVG---R 841
+ + E+ ++ + + A+ A E K+ + + ++V K A+K+ + R
Sbjct: 1533 KKQVEQEKCEIQAALEEAE-ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1591
Query: 842 HHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGK 901
+HT V E + +S+ D+E ++ + ++ +G
Sbjct: 1592 NHT----------RVVETM---------QSTLDAEIRSR--------NDALRVKKKMEGD 1624
Query: 902 DQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFH---------DKNAKKPTFQKKNCKM 952
+ + E ++ Y N G + H D + +++ +
Sbjct: 1625 LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLL 1684
Query: 953 QKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEY 1012
Q T E+ + I Q+ ++ ER+ L QN+ L N KK E V +
Sbjct: 1685 QAEIEELWATLEQTERSRKIAEQE----LLDASERVQLLHTQNTSLINTKKKLENDVSQL 1740
Query: 1013 KEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENS 1072
+ E+++ + + ++++ KK D A + +E LKK + +S ++N
Sbjct: 1741 QSEVEEVIQESRNAEEK-------AKKAITDAAMMAEE----LKKEQDTSAHLERMKKNL 1789
Query: 1073 QVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEM 1132
+ T +Q +D E +QL LK ++ K + V+ L+ E+ +++ E
Sbjct: 1790 EQTVKDLQ-------HRLD-EAEQL--ALKGGKKQIQKLEARVRELEGEVENEQKRNAEA 1839
Query: 1133 HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSI 1192
+ + + ER +++L ++ + + ++ +++ L KVK
Sbjct: 1840 VKGLRKHER-------RVKELTYQTEEDRKNVLRLQDLVDKLQAKVK------------- 1879
Query: 1193 DSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQ 1251
S K++ A ++ + ++K + ELE+ + + + S++++ E+ T S +
Sbjct: 1880 -SYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 107 bits (267), Expect = 8e-23
Identities = 200/1071 (18%), Positives = 445/1071 (41%), Gaps = 131/1071 (12%)
Query: 394 TKSNEAMLRQSVTNLQDQLLQKEQENAKLKEK----LQESQGAPLPLPQESDPDYSAQ-- 447
T+ A +++ +D+L + E + +L+EK L+E L + E+D A+
Sbjct: 848 TEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEER 907
Query: 448 ----VPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISA-NKGFSRKSIMTSAE 502
+ ++ L + + + E E + +L KL + S K + +
Sbjct: 908 CEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 967
Query: 503 GKHKEPPVKRSRSLSPKSSFTDS-----------------EELQKLRKAERKIENLEKAL 545
K K + ++L+ + + D + L L+ E K+ L KA
Sbjct: 968 EKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAK 1027
Query: 546 QLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQ 605
Q+ D+L + E+ K+ L+ R ++ LK +E + ++ K+ ++L +
Sbjct: 1028 TKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQEST--MDMENDKQQLDEKLEK 1085
Query: 606 EDSDAVWNELAYFKRENQ-ELMIQKM--NLEEELDELKVHISIDKAAIQELNRCVAERRE 662
++ + + N ++ + E E+ +QK L+ ++EL I ++A+ R AE++
Sbjct: 1086 KEFE-ISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS-----RAKAEKQR 1139
Query: 663 EQLFRSGED------------------DEVKRSTPEKNGKEMLEQTLQ------------ 692
L R E+ ++ + + +K +++ E TLQ
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKH 1199
Query: 693 --KVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKS---LLKQQQEDTETREKELEQII 747
+ EL ++ + ++ +KL++ +L E D L S + + + + E + LE +
Sbjct: 1200 ADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQV 1259
Query: 748 KGSKDVEKEN----TELQVKISELETEVTSLRRQVAEANAL-----RNENEELINPMEKS 798
K E+E +L + + L+TE RQ+ E +AL R++ E
Sbjct: 1260 SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELK 1319
Query: 799 HQSADRAKSEMATMK-VRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVF 857
HQ + K++ A ++S R+DC + + + K + R + N + +
Sbjct: 1320 HQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK-AELQRALSKANSEVAQWRTKY 1378
Query: 858 ENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGK 917
E + E++ E+ AQ Q + + K + E K + +++ ED +
Sbjct: 1379 ETDAIQRTEELEEAKKKL-AQRLQEAEEHVEAVNAKCASLEKTKQRLQNE-VEDLMLDVE 1436
Query: 918 EIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKS 977
+D K +++ + K +++ +++ S + K KN+ ++S
Sbjct: 1437 RSNAACAALD-KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVY-EES 1494
Query: 978 SSNIILLRERIISLQQQNS-----VLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQT 1032
+ LR +LQQ+ S + + K+ EL + + EK Q + +
Sbjct: 1495 LDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASL 1554
Query: 1033 SRQTIKKLNLDLAGLRKEKEDLLKKL-ESSSEITSLAEENSQVTFP---------RIQVT 1082
+ K L + L L + K ++ +K+ E EI L +++V R +
Sbjct: 1555 EHEEGKILRIQLE-LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRND 1613
Query: 1083 SLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHI-------KEMHEK 1135
+L + M+ ++ +++ +L +A + N + + L + H+ +++ E+
Sbjct: 1614 ALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQ 1673
Query: 1136 ISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSL 1195
++ +ER + + IE+L + S K + L + ++V+ L + S+ +
Sbjct: 1674 LAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLL----HTQNTSLINT 1729
Query: 1196 KQRLNVAVKE-KSQYEQMYQKSKEELEKKDLKLT---LLVSRISETESAMAEIETAASKQ 1251
K++L V + +S+ E++ Q+S+ EK +T ++ + + + A +E K
Sbjct: 1730 KKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM-KKN 1788
Query: 1252 LQELALQSEQVLEGAQKTLLLANEK-VEEFTTFVKALAKELQNDVHVVRRQIRELKKMKK 1310
L++ + L+ A++ L +K +++ V+ L E++N+ +R +K ++K
Sbjct: 1789 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENE---QKRNAEAVKGLRK 1845
Query: 1311 NRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKE 1361
+ K T++ + ++L L++++D + Q +++ K AE +E
Sbjct: 1846 HERRVKELTYQTEEDRKNVLR-----LQDLVD-KLQAKVKSYKRQAEEAEE 1890
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 140 bits (354), Expect = 7e-33
Identities = 239/1183 (20%), Positives = 489/1183 (41%), Gaps = 168/1183 (14%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ K E L +AK +E E++ L QE NDL + A + A +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
L K +IK+ E +++EE N L + +KL C++L D++ L
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDLEL 963
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
A + KEK++T+ K+K + + A + +++ +LQ +++QT
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEM--AGLDETIAKLTKEKKALQEAHQQT----------- 1010
Query: 327 VRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNE 386
L +LQ + +T T + +L QQ+ L ++ + + D+ A+ +KL +
Sbjct: 1011 ----LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAK----RKLEGD 1062
Query: 387 LHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSA 446
L + E+T E +Q L ++L +KE E + L+ K+++ Q + L Q+ + A
Sbjct: 1063 LKLAQESTMDIENDKQQ----LDEKLKKKEFEMSGLQSKIEDEQALGMQL-QKKIKELQA 1117
Query: 447 QV--------PHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIM 498
++ R S + E E+E + E+L+ A S I NK R++
Sbjct: 1118 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEF 1175
Query: 499 TSAEGKHKEPPVKR---SRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDEL 555
+E ++ + +L K + + +E +++ +R + LEK E D+L
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1235
Query: 556 RDAHEKRKERLQMLQTNYRAVKEQL-----KQWEEGSGMTEI----RKIKRADPQQLRQ- 605
E + L+ RA+++QL K+ E+ + ++ +++ + RQ
Sbjct: 1236 ASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQL 1295
Query: 606 EDSDAVWNELAYFKRE-NQELMIQKMNLEEEL-----------------DELKVHISIDK 647
++ D + ++L+ K+ Q++ K LEEE+ D L+ ++
Sbjct: 1296 DEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQ 1355
Query: 648 AAIQELNRCVAERREE--QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTE----LENRL 701
A EL R +++ E Q E D ++R+ + K+ L Q LQ E + +
Sbjct: 1356 EAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKC 1415
Query: 702 KSFEKRSRKLKEGNKKLM---------------KENDFLKSLLKQQQEDTETREKELEQI 746
S EK ++L+ + LM K+ +F K L + +Q+ ET ELE
Sbjct: 1416 ASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEET-HAELEAS 1474
Query: 747 IKGSKDVEKE----NTELQVKISELET---EVTSLRRQVAEANALRNENEELINPMEKSH 799
K S+ + E + + +LET E +L++++++ E + I+ +EK
Sbjct: 1475 QKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1534
Query: 800 QSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFEN 859
+ ++ KSE+ ++ + + ++ + K + + + + ++ I +
Sbjct: 1535 KQVEQEKSEL-----QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1589
Query: 860 LSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEI 919
+ ++ V S +A+ I ++ +G + + E
Sbjct: 1590 MKRNHIRIVESMQSTLDAEIRSRNDAI------RLKKKMEGDLNEMEIQLNHANRMAAEA 1643
Query: 920 VQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSS 979
++ Y N H +A + +++ K Q + V R N
Sbjct: 1644 LRNYRNTQAILKDTQLHLDDALR---SQEDLKEQLA---MVERRAN-------------- 1683
Query: 980 NIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK 1039
LL+ I L+ + ++K AE + + E +LLH Q S T KK
Sbjct: 1684 ---LLQAEIEELRATLEQTERSRKIAEQELLDASE-RVQLLHTQNTS------LINTKKK 1733
Query: 1040 LNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQY 1099
L D++ ++ E ED++++ ++ E + +T + L + +++++
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEE-----KAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 1100 KLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKV 1159
L+ +L + + L +K ++I ++E + R L +++ QK
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLA---------LKGGKKQIQKLEARV---RELEGEVESEQKR 1836
Query: 1160 NLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEE 1219
N+E+ K L+ ++KVK LT + + +I L+ ++ + Y++ ++++E+
Sbjct: 1837 NVEAVKG----LRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 1220 LEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQV 1262
K + + E E E A Q+ +L ++S +V
Sbjct: 1893 SNVNLSKFRRIQHELEEAE----ERADIAESQVNKLRVKSREV 1931
Score = 120 bits (302), Expect = 7e-27
Identities = 231/1136 (20%), Positives = 470/1136 (41%), Gaps = 159/1136 (13%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
++EE KEELA +A ++ + L DL V + E D+ +
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKT 915
Query: 165 ILQVKDAKIQEFEQRESVLKQEIN-DLVKRKIAVDEENAFLRKEFSDL------------ 211
+Q+ +AKI+E +R ++EIN +L +K +++E + L+K+ DL
Sbjct: 916 KIQL-EAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 973
Query: 212 --EKKFKDKSQEIKDTKECV-------QNKEEQNRLVIKNLEEENKKLST---------- 252
E K K+ ++E+ E + + +E ++ + +L+ E K++T
Sbjct: 974 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1033
Query: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSN 312
+ DL LE+ +K L + K + +K +++ ++ + + K ++S
Sbjct: 1034 QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG 1093
Query: 313 KQTELIQKDMDITLVRKELQELQ----NLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRN 368
Q+++ + ++K+++ELQ L ++ A +A+ +Q L+ + +++
Sbjct: 1094 LQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 369 QEDVHTAES----------ISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQE 418
E+ A S +QK+ +L ++ A LR+ + +L ++
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1213
Query: 419 NAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIA 478
++K+KL++ + + + + +L + + Q SEI+ +E+
Sbjct: 1214 LQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEE---- 1269
Query: 479 NEKLSENISANKG-FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDS-EELQKLRKAER 536
++L +++A + +S S + K+ V S+ K +FT EEL++ + E
Sbjct: 1270 QQRLINDLTAQRARLQTESGEYSRQLDEKDTLV--SQLSRGKQAFTQQIEELKRQLEEEI 1327
Query: 537 KIEN-LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKI 595
K ++ L ALQ + D LR+ +E+ +E LQ ++ QW I++
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387
Query: 596 KRAD--PQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQEL 653
+ + ++L Q DA + + L K L+ E+++L + + AA L
Sbjct: 1388 EELEEAKKKLAQRLQDAE-EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1446
Query: 654 NRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSR---- 709
++ ++N ++L + QK E L++ +K SR
Sbjct: 1447 DK-----------------------KQRNFDKILAEWKQKCEETHAELEASQKESRSLST 1483
Query: 710 ---KLKEGNKKLMKENDFLKSLLKQ-QQEDTETRE------KELEQIIKGSKDVEKENTE 759
K+K ++ + + + LK K QQE ++ E K + ++ K K VE+E +E
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 760 LQVKISE----LETEVTSLRRQVAEANALRN-------ENEELINPMEKSHQSADRAKSE 808
LQ + E LE E + R E N +++ E +E I+ M+++H +
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 809 MATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFEN------LSK 862
++RS R D ++ K K + LNH+ ++ + N + K
Sbjct: 1604 TLDAEIRS-RNDA------IRLK-KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILK 1655
Query: 863 D---GWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEI 919
D +D S D + Q + +VE + E + + + TE S ++I
Sbjct: 1656 DTQLHLDDALRSQEDLKEQLA------MVERRANLLQAEIEELRATLEQTERS----RKI 1705
Query: 920 VQTYLNIDGKTPKDYFHDKNAKKPTFQKK----NCKMQKSSHTAVPTRVNREKYKNITAQ 975
+ L +D H +N +KK ++Q + N E+ A+
Sbjct: 1706 AEQEL-LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEE----KAK 1760
Query: 976 KSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQ-RFQTSR 1034
K+ ++ ++ E + Q ++ L+ KK E +VK+ L H+ ++Q + +
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD-------LQHRLDEAEQLALKGGK 1813
Query: 1035 QTIKKLNLDLAGLRKEKEDLLKK-LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLE 1093
+ I+KL + L E E K+ +E+ + + ++T+ + + + R DL
Sbjct: 1814 KQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTY-QTEEDRKNILRLQDL- 1871
Query: 1094 MKQLQYKLKNATN--ELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKR 1147
+ +LQ K+K+ E ++ SNV KF + E ++E E+ E + R
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHE--LEEAEERADIAESQVNKLR 1925
Score = 110 bits (276), Expect = 7e-24
Identities = 197/960 (20%), Positives = 392/960 (40%), Gaps = 120/960 (12%)
Query: 492 FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENL---EKALQLK 548
F K ++ SAE + KE + K +E K ++ E K+ L + LQL+
Sbjct: 838 FKIKPLLKSAETE-KEMANMKEEFEKTKEELAKTEA--KRKELEEKMVTLMQEKNDLQLQ 894
Query: 549 SQ-ENDELRDAHEKRKERLQ---MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
Q E D L DA E+ + ++ L+ + V E+ + EE + +K K D
Sbjct: 895 VQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEE---LDELKVHISIDKAAIQELNRCVAERR 661
++D D + LA ++E + NL EE LDE ++ +K A+QE ++ +
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ E+D+V T K E L+ E E +++ +R+++ EG+ KL +E
Sbjct: 1015 Q------AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE 1068
Query: 722 NDFLKSLLKQQQEDTETREKELEQIIKGSK---------DVEKENTELQVKISELETEVT 772
+ + +QQ D + ++KE E SK ++K+ ELQ +I ELE E+
Sbjct: 1069 ST-MDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE 1127
Query: 773 SLRRQVAEANALRNE-NEELINPMEKSHQSADRAKSEMATMKVRSG-----RYDCKTTMT 826
+ R A+A R++ + EL E+ ++ +++ K R R D +
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 827 KVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWE---DVSESSSDSEAQTSQTL 883
+ + AA L I + V + L K+ E ++ + +S+ E S+
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET-VSKAK 1246
Query: 884 GTI------IVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHD 937
G + + + +I E+ + + +D T E + +D K
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS 1306
Query: 938 KNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSV 997
+ + T Q + K Q + + Q S + LLRE+ Q+ +
Sbjct: 1307 RGKQAFTQQIEELKRQLEEEIKAKSALAH------ALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 998 LQNAKKTAELSVKEYK--------EVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRK 1049
LQ A A V +++ + E+L ++ QR Q + + ++ +N A L K
Sbjct: 1361 LQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK 1420
Query: 1050 EKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELT 1109
K+ +L++ E + E + + R+ D + + + K + EL
Sbjct: 1421 TKQ----RLQNEVEDLMIDVERTNAACAALD----KKQRNFDKILAEWKQKCEETHAELE 1472
Query: 1110 KQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSE 1169
++L EL + +E +++ ++R+ NK
Sbjct: 1473 ASQKESRSLSTELFKIKNAYEESLDQLETLKRE---------------------NK---- 1507
Query: 1170 MLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTL 1229
NL +++ LTE+ + I L++ +EKS+ + ++++ LE ++ K+
Sbjct: 1508 ---NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILR 1564
Query: 1230 LVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAK 1289
+ +++ +S + +++ ++ +++E Q TL + ++ ++ L K
Sbjct: 1565 IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL---DAEIRSRNDAIR-LKK 1620
Query: 1290 ELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNI-----SRSDLEEILDTE 1344
+++ D++ + Q+ +M +A + + L + L++ S+ DL+E L
Sbjct: 1621 KMEGDLNEMEIQLNHANRMA--AEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV 1678
Query: 1345 D------QVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAV----LEKINEKKKL 1394
+ Q EIE+ + E + +K+ E +L AS ++ + IN KKKL
Sbjct: 1679 ERRANLLQAEIEELRATLEQTER----SRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1734
Score = 107 bits (266), Expect = 1e-22
Identities = 221/1188 (18%), Positives = 503/1188 (42%), Gaps = 167/1188 (14%)
Query: 200 ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRC-TDLL 258
++A KE ++++++F+ +E+ T+ + KE + ++V E+ + +L + D L
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTE--AKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 259 NDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
D E+ Q L K K +AKIK + E ++ E ++ A +L ++ +EL
Sbjct: 903 ADAEERCDQ---LIKTKIQLEAKIK----EVTERAEDEEEINAELTAKKRKLEDECSELK 955
Query: 319 QK--DMDITL--VRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHT 374
+ D+++TL V KE +N K L +++ L+ K+ + ++ +
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKN----------LTEEMAGLDETIAKLTKEKKALQE 1005
Query: 375 AESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPL 434
A + L E TK+ + L Q V +L+ L Q+++ L+ ++ +G L
Sbjct: 1006 AHQQTLDDLQAEEDKVNTLTKA-KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG-DL 1063
Query: 435 PLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSR 494
L QES D +++ + L EKLK ++S G
Sbjct: 1064 KLAQESTMDI--------------------ENDKQQLDEKLKKKEFEMS-------GLQS 1096
Query: 495 KSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDE 554
K A G + +K ++ + E KAE++ +L + L+ S+ +E
Sbjct: 1097 KIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 555 LRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNE 614
A + E + + ++ ++ L EE + E A LR++ +D+V
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDL---EEATLQHE------ATAATLRKKHADSV--- 1204
Query: 615 LAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEV 674
A + L K LE+E E+K+ I + ++ +++ A+ E++ R+ ED
Sbjct: 1205 -AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK--AKGNLEKMCRALEDQLS 1261
Query: 675 KRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQE 734
+ T E+ + ++ + L+ + ++ + E D L S L + ++
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ-----------LDEKDTLVSQLSRGKQ 1310
Query: 735 DTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINP 794
+ +EL++ +L+ +I +L+ + + LR + EE
Sbjct: 1311 AFTQQIEELKR-------------QLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEA 1357
Query: 795 MEKSHQSADRAKSEMATMKVRSGRYDCKTT--MTKVKFKAAKKNCSVGRHHTVLNH---S 849
+ ++ +A SE+A + + + T + + K K A++ H +N S
Sbjct: 1358 KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCAS 1417
Query: 850 IKVMSNVFENLSKDGWEDVSESSSDSEA--QTSQTLGTIIVETSQKISPTEDGKDQKESD 907
++ +N +D DV +++ A + + I+ E QK T
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA-------- 1469
Query: 908 PTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNRE 967
E SQ + + + I K+ + + + T +++N +Q +
Sbjct: 1470 ELEASQKESRSLSTELFKI-----KNAYEESLDQLETLKRENKNLQ-------------Q 1511
Query: 968 KYKNITAQ--KSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQV 1025
+ ++T Q + I L + ++Q+ S LQ A + AE S++ E + L Q ++
Sbjct: 1512 EISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH--EEGKILRIQLEL 1569
Query: 1026 SDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLS 1085
+ + + R+ +K + ++ +++ +++ ++S+ + AE S+ R++
Sbjct: 1570 NQVKSEVDRKIAEK-DEEIDQMKRNHIRIVESMQSTLD----AEIRSRNDAIRLK----- 1619
Query: 1086 PSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHI-------KEMHEKISR 1138
+ M+ ++ +++ +L +A + N + + L + H+ +++ E+++
Sbjct: 1620 --KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAM 1677
Query: 1139 MERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQR 1198
+ER + + IE+L+ + S K + L + ++V+ L + S+ + K++
Sbjct: 1678 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL----HTQNTSLINTKKK 1733
Query: 1199 LNVAVKE-KSQYEQMYQKSKEELEKKDLKLT---LLVSRISETESAMAEIETAASKQLQE 1254
L + + + + E + Q+++ EK +T ++ + + + A +E K L++
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE-RMKKNLEQ 1792
Query: 1255 LALQSEQVLEGAQKTLLLANEK-VEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRD 1313
+ L+ A++ L +K +++ V+ L E++++ +R + +K ++K+
Sbjct: 1793 TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE---QKRNVEAVKGLRKHER 1849
Query: 1314 ACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKE 1361
K T++ + +IL L++++D + Q +++ K AE +E
Sbjct: 1850 KVKELTYQTEEDRKNILR-----LQDLVD-KLQAKVKSYKRQAEEAEE 1891
Score = 100 bits (249), Expect = 1e-20
Identities = 213/1123 (18%), Positives = 468/1123 (41%), Gaps = 119/1123 (10%)
Query: 232 KEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIE 291
K + + N++EE +K ++L ++ L +EK +++ D+L +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 292 ARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAEL 351
A + + QL + +L K ++T ++ +E+ N+ TA++ +L
Sbjct: 905 AEERCD-----------QLIKTKIQLEAKIKEVTERAEDEEEI------NAELTAKKRKL 947
Query: 352 IQQLQVLNMDTQ----KVLRNQEDVHTAESISYQKLYNELHICFET----TKSNEAMLRQ 403
+ L D + + +++ H E+ + L E+ ET TK +A+
Sbjct: 948 EDECSELKKDIDDLELTLAKVEKEKHATEN-KVKNLTEEMAGLDETIAKLTKEKKALQEA 1006
Query: 404 SVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE-TLMV 462
L D ++++ N K K++ Q L + + ++ + LE L +
Sbjct: 1007 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVD-DLEGSLEQEKKIRMDLERAKRKLEGDLKL 1065
Query: 463 SQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSF 522
+Q+S ++ +K ++ +EKL + G K A G + +K ++ +
Sbjct: 1066 AQESTMDIENDKQQL-DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 1124
Query: 523 TDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQ 582
E KAE++ +L + L+ S+ +E A + E + + ++ ++ L
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL-- 1182
Query: 583 WEEGSGMTEIRKIKRADPQQLRQEDSDAV---WNELAYFKRENQELMIQKMNLEEELDEL 639
EE + E A LR++ +D+V ++ +R Q+L +K ++ E+D+L
Sbjct: 1183 -EEATLQHE------ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1235
Query: 640 KVH---ISIDKAAIQELNRCVAER------REEQLFRSGEDDEVKRSTPEKNGKEMLEQT 690
+ +S K ++++ R + ++ +EE+ R D +R+ + E Q
Sbjct: 1236 ASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQL 1295
Query: 691 LQK---VTELENRLKSFEKRSRKLKEGNKKLMKENDFLK----------SLLKQQQEDTE 737
+K V++L ++F ++ +LK ++ +K L LL++Q E+ +
Sbjct: 1296 DEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQ 1355
Query: 738 TREKELEQII-KGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELIN--- 793
+ EL++ + K + +V + T+ + + E+ ++++A+ E+ E +N
Sbjct: 1356 EAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKC 1415
Query: 794 -PMEKSHQ-----------SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGR 841
+EK+ Q +R + A + + +D K K + +
Sbjct: 1416 ASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1475
Query: 842 HHT-VLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDG 900
+ L+ + + N +E S D E + + + + + S L I E ++I E
Sbjct: 1476 KESRSLSTELFKIKNAYEE-SLDQLETLKRENKNLQQEISD-LTEQIAEGGKRIHELEKI 1533
Query: 901 KDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQK-----KNCKMQKS 955
K Q E + +E Q +E + + +GK + K +K + K
Sbjct: 1534 KKQVEQEKSE-LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR 1592
Query: 956 SHTAVPTRVNREKYKNITAQ-KSSSNIILLRERII-SLQQQNSVLQNAKKTAELSVKEYK 1013
+H R+ + A+ +S ++ I L++++ L + L +A + A +++ Y+
Sbjct: 1593 NH----IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1648
Query: 1014 EVNEKLLHQQQVSDQRFQTS---RQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEE 1070
L Q D ++ ++ + + L+ E E+L LE + +AE+
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1708
Query: 1071 NSQVTFPRIQV-----TSL-SPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLA 1124
R+Q+ TSL + + ++ ++ Q+Q ++++ E K +
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM 1768
Query: 1125 KEEHIKEMHEKISRMERDITMKRHL---IEDLKFR-QKVNLESNKSFSEMLQNLDKKVKT 1180
E +K+ + + +ER MK++L ++DL+ R + + K + +Q L+ +V+
Sbjct: 1769 MAEELKKEQDTSAHLER---MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRE 1825
Query: 1181 LTEEC-SNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRI-SETE 1238
L E S +K +++++K + E+ E YQ EE K L+L LV ++ ++ +
Sbjct: 1826 LEGEVESEQKRNVEAVK---GLRKHERKVKELTYQ--TEEDRKNILRLQDLVDKLQAKVK 1880
Query: 1239 SAMAEIETAASKQLQELA--LQSEQVLEGAQKTLLLANEKVEE 1279
S + E A + L+ + + LE A++ +A +V +
Sbjct: 1881 SYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNK 1923
Score = 97.1 bits (240), Expect = 1e-19
Identities = 194/1011 (19%), Positives = 408/1011 (40%), Gaps = 152/1011 (15%)
Query: 89 LEGISVEEAMV---TRTQL-LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL--TQ 142
L+ + EE V T+ ++ LE+++ L+ L + +K+ L + + DL Q
Sbjct: 1011 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL---EQEKKIRMDLERAKRKLEGDLKLAQ 1067
Query: 143 VVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENA 202
++ +E +KQ+ + K +K + +KI++ + L+++I +L R ++EE
Sbjct: 1068 ESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE 1127
Query: 203 FLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLE 262
R + EK+ D S+E+++ E ++ I E NKK + DLE
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI----EMNKKREAEFQKMRRDLE 1183
Query: 263 KLRKQE----AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
+ Q A LRK+ + A++ DNL ++++E +S+ + +++ + + +
Sbjct: 1184 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE---MKMEIDDLASNME 1240
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESI 378
+ K + L++ + T +Q LI L Q ES
Sbjct: 1241 TVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQ-----------TESG 1289
Query: 379 SYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQG--APLPL 436
Y + +E + Q + L+ QL ++ + + L LQ S+ L
Sbjct: 1290 EYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLRE 1349
Query: 437 PQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQ--EKLKIANEKLSENISANKGFSR 494
E + + A++ S ++ E K E + +Q E+L+ A +KL++ +
Sbjct: 1350 QYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ------- 1402
Query: 495 KSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDE 554
AE +H E + S L K +++++N + L + + +
Sbjct: 1403 -----DAE-EHVEAVNAKCAS---------------LEKTKQRLQNEVEDLMIDVERTNA 1441
Query: 555 LRDAHEKRKERLQMLQTNYRAVKE------QLKQWEEGSGMTEIRKIKRADPQQLRQEDS 608
A +K++ + ++ E + Q E S TE+ KIK A + L
Sbjct: 1442 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESL----- 1496
Query: 609 DAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRS 668
++L KREN+ NL++E+ +L I+ I EL + + +E+
Sbjct: 1497 ----DQLETLKRENK-------NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545
Query: 669 GEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSL 728
+E + S + GK L+ EL N++KS E ++K+ ++++ + +
Sbjct: 1546 AALEEAEASLEHEEGK-----ILRIQLEL-NQVKS---------EVDRKIAEKDEEIDQM 1590
Query: 729 LKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRN-E 787
+ E+ + L+ I+ D + +++ ++E+E ++ R AE ALRN
Sbjct: 1591 KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE--ALRNYR 1648
Query: 788 NEELINPMEKSH-----QSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRH 842
N + I + H +S + K ++A ++ R+ + + + +++ +
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1708
Query: 843 ------------HTVLNHSIKVMSNVFENLS--KDGWEDVSESSSDSEAQTSQTLGTIIV 888
HT I + ++S + ED+ + + ++E + + + +
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM 1768
Query: 889 ETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKK 948
+ +KE D + + K + QT ++ + + K QK
Sbjct: 1769 MAEEL---------KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKL 1819
Query: 949 NCKM----------QKSSHTAVP-TRVNREKYKNITAQ--KSSSNIILLRERIISLQQQN 995
++ QK + AV R + K K +T Q + NI+ L++ + LQ +
Sbjct: 1820 EARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAK- 1878
Query: 996 SVLQNAKKTAELSVKEYKEVN----EKLLHQQQVSDQRFQTSRQTIKKLNL 1042
+++ K+ AE +E VN ++ H+ + +++R + + KL +
Sbjct: 1879 --VKSYKRQAE-EAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRV 1926
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 140 bits (354), Expect = 7e-33
Identities = 289/1411 (20%), Positives = 615/1411 (43%), Gaps = 209/1411 (14%)
Query: 113 KEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA--KDRKVL---EILQ 167
K EL + ++ +W+ ++LQV + + E+ +Q+ E KD++++ I +
Sbjct: 613 KTELESLKHQQDALWT--EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 168 VKDAKIQEFEQRESVLKQ---EINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
+ + +++ + +++ L+ E+++++K + ++EE + L+ + ++++ + K E K+
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQ-EAHLRKEKY---STDA 280
+ ++Q +IK E ++ D +N LE L K+ + HL++ + + +A
Sbjct: 731 ------HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEA 784
Query: 281 KIKTFEDNLIEARKEVEVSQS-------KYNALSLQLSNKQTELIQKDMDITLVRKELQE 333
IK E L +A +++V QS + A QL+ Q +L+ + + L+ K++ E
Sbjct: 785 DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE 844
Query: 334 LQNLYKQNST----HTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAE------------- 376
++ K T H Q +L+QQL+ N + ++ +++ V+ ++
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904
Query: 377 --------------------SISYQKLY---NELHIC---FETTKSNEAM----LRQSVT 406
I QKL + +HI +ET N+ ++Q
Sbjct: 905 ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Query: 407 NLQDQLLQKE-QENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSS------LET 459
+Q+ L +K + AKLK++L+ + L L Q+ + ++A++ +S +
Sbjct: 965 EMQETLKKKLLDQEAKLKKELENTA---LELSQK-EKQFNAKMLEMAQANSAGISDAVSR 1020
Query: 460 LMVSQKSEIEYLQEKLKIANEKLSENISA-----NKGFSRKSIMTSAEGKHKEPPV---K 511
L +QK +IE L E + +L++ IS N+ + + + KE V K
Sbjct: 1021 LETNQKEQIESLTE---VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077
Query: 512 RSRSLSPKSSFTDSEELQKLR----KAERKIENLEKALQLKSQENDELRDAHEKRKERLQ 567
+ L ++E+ L+ K + + L++ L+ KS + L K K L+
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137
Query: 568 MLQTNYRA-------VKEQLKQW-----EEGSGMTEIR-KIKRADPQ-----QLRQEDSD 609
L+ + ++EQL + E+ ++E+ K+K D + ++ +
Sbjct: 1138 KLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Query: 610 AVWNELAYFKRENQELMIQ--------KMNLEEELDELKVHISIDK--AAIQELNRC--- 656
++ ++ FK+ ++EL IQ + LE + +EL ++IS K A + ++ C
Sbjct: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL-INISSSKTNAILSRISHCQHR 1256
Query: 657 VAERREEQLFR----SGEDDEVKRSTPEKNGKEM-LEQTLQKVTELENRLKSFEKRSRKL 711
+ +E L + S + ++++ T E+N + +Q ++ E EN++KS + L
Sbjct: 1257 TTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESL 1316
Query: 712 KEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEV 771
+ L KE + +++ +KEL + I +++E E +V+IS L ++
Sbjct: 1317 VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376
Query: 772 TSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEM------ATMKVRSGRYDCKTTM 825
T L Q+ + +L +E E I+ + K + D K E+ + KV + + + +
Sbjct: 1377 TDLNVQLQNSISL-SEKEAAISSLRKQY---DEEKCELLDQVQDLSFKVDTLSKEKISAL 1432
Query: 826 TKV-----KFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTS 880
+V KF KK T +++K + E SK+ +E + + E
Sbjct: 1433 EQVDDWSNKFSEWKKKAQ--SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQ 1490
Query: 881 QTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQ-----TYLNIDGKTPKDYF 935
Q ++ ++ + ++KES+ + ++Q I++ T I+ ++ +
Sbjct: 1491 QNKRFDCLK--GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL 1548
Query: 936 HDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQN 995
+ N +K K+ +QK H + EK + +++ I+ L ++ S++ +
Sbjct: 1549 KNYNQQKDIEHKE--LVQKLQHF---QELGEEKDNRV--KEAEEKILTLENQVYSMKAEL 1601
Query: 996 SVLQNAKKTAELSVKEYKEVNEKLLHQQQVSD------QRFQTSRQTIKKLNLDLAGLRK 1049
+ + LSVK KE K L + S+ + + + Q I + L +
Sbjct: 1602 ETKKKELEHVNLSVKS-KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQME 1660
Query: 1050 EKEDLLKKLESS--SEI-TSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNAT- 1105
EKE+ KK S SE+ T L E +V ++ S+ S+S L + + + T
Sbjct: 1661 EKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTE 1720
Query: 1106 -NELTKQSSNVKTLKFELLAKEEHIKEMHEKISRM--ERDITMKRHLIEDLKFRQK-VNL 1161
E Q KT + ++ + ++ E + + R+ E++ T+ H +++++ + L
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780
Query: 1162 ESNKSFSEMLQNLDKKVKTLTEECSNKKVSI----DSLKQRLNVAVKEKSQYEQMYQKSK 1217
E ++ Q++ ++ EE NKK S+ K+ ++ K E ++ +
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 1218 EELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELA-----LQSEQVLEGAQKTLLL 1272
+ L++K+L +L +I E +S + + +++EL LQ+ Q ++G K L
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 1273 ANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKT--STHKAQTLAASIL 1330
E EE ++ H+V+ ++ + + N K + + Q L I+
Sbjct: 1900 LEENTEE------------KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIV 1947
Query: 1331 NISRSDLEEILDTEDQVEIEKTKIDAENDKE 1361
+ + DL +L E Q E+E K + + ++E
Sbjct: 1948 RLQK-DL-RMLRKEHQQELEILKKEYDQERE 1976
Score = 139 bits (349), Expect = 2e-32
Identities = 273/1376 (19%), Positives = 579/1376 (42%), Gaps = 207/1376 (15%)
Query: 103 QLLEEELSSLKEELA-LCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK--- 158
++ EEE++ L+ + + +E K + +L + +S + E+ + + K
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKR-------KIAVDEENAFLRKEFSDL 211
D ++ I + + + +Q S +KQE+ D++K+ K+ E RKE +L
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE-QEL 496
Query: 212 EKKFKDKSQEIKDTKECV------------QNKEEQNRLVIKNLEEENKKLSTRCTDLLN 259
KK + + +E ++ + Q KE+Q L ++ LE + K + T + L
Sbjct: 497 TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLR 556
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQL-SNKQTELI 318
DL+ QEA E Y T +I E +L ++ +E +QSK A+ L+ NK + I
Sbjct: 557 DLQ----QEA----ETYRT--RILELESSLEKSLQE-NKNQSKDLAVHLEAEKNKHNKEI 605
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMD--TQKVLRNQEDVHTAE 376
+V K EL++L Q ++ ++++Q M+ +K + +E + +
Sbjct: 606 -----TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
Query: 377 SISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPL 436
I +Q E++ E T + + + +L +L + + KL+E+L + +
Sbjct: 661 EIIFQAHIEEMN---EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717
Query: 437 PQESDPDYSAQVPH---------RPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENIS 487
QE + Q H + S++ + K +I L+ LK ++ L E+ +
Sbjct: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQA 777
Query: 488 ANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQL 547
+ ++ + +EG+ ++ K L S+ + Q E+ + +K L L
Sbjct: 778 HVENL--EADIKRSEGELQQASAK----LDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831
Query: 548 KSQE---NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
+++ ++ + ++K+ L + V++ ++Q E+ + E + + +
Sbjct: 832 ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891
Query: 605 QEDSDAVWNELAYFKRENQELMIQ-KMNLEEELDELKVHISIDKAAIQELNRCVAERREE 663
ED + + E + +++Q + ++E++ L +S + +I LN E
Sbjct: 892 LEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN--------E 943
Query: 664 QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLK-----SFEKRSRKLKEGNKKL 718
+ ++ E K ++ KEM E +K+ + E +LK + + S+K K+ N K+
Sbjct: 944 EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
Query: 719 MKE--------NDFLKSLLKQQQED----TETREKELEQIIK-GSKDVEKENTELQ---- 761
++ +D + L Q+E TE +EL +I K + ++ ELQ
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063
Query: 762 VKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDC 821
+++ E E EV L++++ + E + I +++ D +E+ + +
Sbjct: 1064 IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVN 1123
Query: 822 KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQ 881
+ K KA + V LN S+K + + E L ++ + + + + S+
Sbjct: 1124 SLAQDETKLKAHLEKLEVD-----LNKSLKENTFLQEQL-----VELKMLAEEDKRKVSE 1173
Query: 882 TLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEI---VQTYLNIDGKTPKDYFHDK 938
T ++T+ + + +K + ED + K++ + L+I K + K
Sbjct: 1174 L--TSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAK 1231
Query: 939 NAK--KPTFQKKNCKMQKSSHTAVPTRVNRE--------------KYKNITAQKSSSNII 982
+ + K N + + SH T +E + + +T ++++ N I
Sbjct: 1232 TNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLN-I 1290
Query: 983 LLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNL 1042
++ L+++ + +++ K E V E + + ++ +QQQ + ++ Q K+L+
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
Query: 1043 DLAGLRKEKEDLL-KKLESSS---EIT----------SLAEENSQVTFPRIQ-------- 1080
++ + KE+L KK+E SS ++T SL+E+ + ++ R Q
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
Query: 1081 ----------VTSLSPSRSMDLEM------KQLQYKLKNATNELTKQSSNVKTLKFELLA 1124
V +LS + LE K ++K K A + T+ + VK L+ +L
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK-KKAQSRFTQHQNTVKELQIQLEL 1469
Query: 1125 KEEHIKEMHEKISRMERDITMKRHLIEDLKFR---QKVNLESNKSFSEM-LQNLDKKVKT 1180
K + E E+I+ ++ ++ + + LK K +E +S E L++ ++
Sbjct: 1470 KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIME 1529
Query: 1181 LTEECSNKKVSIDSL-------KQRLNVAVKEKSQYEQMYQ------------------- 1214
L + + K + I+SL Q+ ++ KE Q Q +Q
Sbjct: 1530 LEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
Query: 1215 --------KSKEELEKKDLKLTLLVSRISETESAMAE--IETAASKQLQELALQSEQVLE 1264
K++ E +KK+L+ L + E E E +E+ ++ +L EL ++EQ +
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIA 1649
Query: 1265 GAQKTLL-LANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTST 1319
+K LL EK E++ ++ EL + R++ L++ K+ ++ ++ T
Sbjct: 1650 AIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSET 1705
Score = 135 bits (341), Expect = 2e-31
Identities = 267/1319 (20%), Positives = 543/1319 (41%), Gaps = 235/1319 (17%)
Query: 101 RTQLLEEELSSLKE----ELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSE 156
+ +LL++E KE L L Q +K+F + + Q + ++ VS + +K++ E
Sbjct: 971 KKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE 1030
Query: 157 AK-------------------DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAV 197
+ +++ E+ ++ + ++QE EQ + LKQ+I K +
Sbjct: 1031 SLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEM 1090
Query: 198 DEENAFLRKE-------FSDLEKKFKDKSQEIKD-------------------TKECVQN 231
++E +L++E ++L+++ K KS + K +N
Sbjct: 1091 NKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN 1150
Query: 232 KEEQNRLV-IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLI 290
Q +LV +K L EE+K+ + T KL+ + + K S + K+ ED +
Sbjct: 1151 TFLQEQLVELKMLAEEDKRKVSELTS------KLKTTDEEFQSLKSSHEKSNKSLEDKSL 1204
Query: 291 EARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYK-----QNSTHT 345
E +K S+ A+ L + K+TE + + L+ + + Q+ T
Sbjct: 1205 EFKK-----LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK 1259
Query: 346 AQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSV 405
++A LI+ V ++ Q LR + +IS+Q+ ++L KS +A + V
Sbjct: 1260 VKEALLIKTCTVSELEAQ--LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 406 TNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQK 465
T + + LQKE N + + E + L +E + +A ++ ++ + +K
Sbjct: 1318 T--EKEALQKEGGNQQ--QAASEKESCITQLKKELSENINA-------VTLMKEELKEKK 1366
Query: 466 SEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDS 525
EI L ++L N +L +IS ++ + S + + K + + + LS K
Sbjct: 1367 VEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK 1426
Query: 526 EELQKLRKAE---RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQ 582
E++ L + + K +K Q + + H+ + LQ ++ +LK
Sbjct: 1427 EKISALEQVDDWSNKFSEWKKKAQSRFTQ-------HQNTVKELQ--------IQLELKS 1471
Query: 583 WEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELD----- 637
E +I +K QQ ++ D E K E +E NLE EL
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE-----SNLETELKSQTAR 1526
Query: 638 --ELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVT 695
EL+ HI+ I+ LN + +++ D E K L Q LQ
Sbjct: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQK------DIEHKE----------LVQKLQHFQ 1570
Query: 696 ELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
EL E++ ++KE +K++ L++ + + + ET++KELE + K E+
Sbjct: 1571 ELG------EEKDNRVKEAEEKILT----LENQVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 756 ENTELQVKI-SELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKV 814
E L+ ++ SE ++ L+R+ AE + + L EK Q +S ++ +
Sbjct: 1621 ELKALEDRLESESAAKLAELKRK-AEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT 1679
Query: 815 RSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSD 874
+ + + + + K K+ + + S ++ S K ++ E D V ++ +
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQS---ETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE 1736
Query: 875 SEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDY 934
+ + L E + + K++ S E + Q +E + + + K
Sbjct: 1737 KISVLQRNL----TEKEKLLQRVGQEKEETVSSHFE-MRCQYQERLIKLEHAEAKQ---- 1787
Query: 935 FHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKN-ITAQKSSSNIILLRERIISLQQ 993
H+ + Q++ + K V V +E KN I A+++ N+
Sbjct: 1788 -HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVF---------DD 1837
Query: 994 QNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKED 1053
LQ + T ++ ++ KE++ L+ Q++V ++ ++ + EK
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVH------------RVEMEELTSKYEKLQ 1885
Query: 1054 LLKKLESSSEITSLAEENSQVTFPR--IQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQ 1111
L++++ ++ T L EEN++ +Q LS +M+ + L++KL A E K
Sbjct: 1886 ALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS---NMEAQHNDLEFKLAGAEREKQKL 1942
Query: 1112 SSNVKTLKFEL------------LAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKV 1159
+ L+ +L + K+E+ +E EKI + + D+ +K + +++
Sbjct: 1943 GKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN-----STLKQL 1997
Query: 1160 NLESNKSFSEMLQNLDKKVK-TLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKE 1218
E N ++ Q L+ +K T+ + + ++S ++ N +K+ ++ + +++ +
Sbjct: 1998 MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAK 2057
Query: 1219 ELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEG------------- 1265
E+ +L +R E + + +++T QL+EL + +Q LE
Sbjct: 2058 RYEE------ILDAREEEMTAKVRDLQT----QLEELQKKYQQKLEQEENPGNDNVTIME 2107
Query: 1266 -----AQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTST 1319
AQKT L+++ K++E +E + +H + + LKK +KN A T
Sbjct: 2108 LQTQLAQKTTLISDSKLKE---------QEFREQIHNLEDR---LKKYEKNVYATTVGT 2154
Score = 131 bits (330), Expect = 4e-30
Identities = 271/1392 (19%), Positives = 571/1392 (41%), Gaps = 188/1392 (13%)
Query: 106 EEELSSLKEELALCQADKEFVWS-LWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+E + S KE+ L ++KE + L +RLQ E EK K K
Sbjct: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQ--------------ELEKIKDLHMAEKTKL 344
Query: 165 ILQVKDAK--IQEFEQRESVL----KQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
I Q++DAK I++ EQ + ++ K+++++ ++ K +EE A LR + + ++
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMK---EEEIAQLRSRIKQMTTQGEEL 401
Query: 219 SQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
++ + ++ + E+ + EE +KL + + +EK ++ E+ S
Sbjct: 402 REQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE------ERISL 455
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLY 338
++ + +++ K + S +Q +QK + L RKE Q L
Sbjct: 456 QQELSRVKQEVVDVMK--------------KSSEEQIAKLQKLHEKELARKE----QELT 497
Query: 339 KQNSTHTAQQAELIQQLQV-LNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSN 397
K+ T ++ E +Q++V L + L+ ++ ES++ ++L + +++
Sbjct: 498 KKLQT---REREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554
Query: 398 EAMLRQSVTNLQDQLLQKEQENAK-LKEKLQESQGAPLPLPQES---DPDYSAQV-PHRP 452
L+Q + ++L+ E K L+E +S+ + L E + + + V H+
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
Query: 453 SLSSLETLMVSQKSE-IEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVK 511
L SL+ + +E ++ L+++ + EKL E K K + +E K
Sbjct: 615 ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEK 674
Query: 512 RSRSLSPKSSFTD--SEELQKLRKAERKIE--------NLEKALQLKSQENDELRDAHEK 561
L K + + S EL ++ KA K+E +K Q + DE ++ H++
Sbjct: 675 TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ 734
Query: 562 R-----KERLQMLQTNYRAVKEQLKQWE-----------EGSGMTEIRK--IKRADP--- 600
+ KE +Q +A+K+Q+ Q E E E + IKR++
Sbjct: 735 QVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ 794
Query: 601 ------------QQLRQEDSDAVWNELAYFKR-----ENQELMIQKMNLEEELDELKVHI 643
Q E + A +LA ++ E + +++ K E E + V
Sbjct: 795 QASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCT 854
Query: 644 SID--KAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENR- 700
+D K +Q+L + + ++ E + +V S E KE EQT Q + E EN
Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ-EQTKQILVEKENMI 913
Query: 701 LKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTEL 760
L+ E + ++++ +KL + D + L ++ + + +EK++E++ + +K++++ L
Sbjct: 914 LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE---TL 970
Query: 761 QVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYD 820
+ K+ + E + L++++ ++ E+ N A+ A A ++ + + +
Sbjct: 971 KKKLLDQEAK---LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
Query: 821 CKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTS 880
++T+V H LN I + N + +++ E + Q
Sbjct: 1028 QIESLTEV-------------HRRELNDVISIWEKKL-NQQAEELQEIHEIQLQEKEQE- 1072
Query: 881 QTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNA 940
+ E QKI K++ KEI T+L +G N
Sbjct: 1073 ------VAELKQKILLFGCEKEE-----------MNKEI--TWLKEEGVKQDTTL---NE 1110
Query: 941 KKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQN 1000
+ ++K+ + + + + EK + + KS L+E+++ L+ ++
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLE-VDLNKSLKENTFLQEQLVELKMLAE--ED 1167
Query: 1001 AKKTAELS--VKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLA----GLRKEKEDL 1054
+K +EL+ +K E + L + S++ + KKL+ +LA K+ E L
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227
Query: 1055 LKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMD------LEMKQLQYKLKNATNEL 1108
L+ ++E+ +++ + RI ++ + + +L+ +L+ T E
Sbjct: 1228 LE--AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 1109 TKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFS 1168
+ + + +L KE IK M I + +T K L ++ +Q+ E +
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESL---VTEKEALQKEGGNQQQAASEKESCIT 1342
Query: 1169 EMLQNLDKKVKTLT---EECSNKKVSIDSLKQR---LNVAVKEK---SQYEQMYQKSKEE 1219
++ + L + + +T EE KKV I SL ++ LNV ++ S+ E +++
Sbjct: 1343 QLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQ 1402
Query: 1220 LEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEE 1279
+++ +L V +S +++ + +A +Q+ + + + + + AQ V+E
Sbjct: 1403 YDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKE 1462
Query: 1280 FTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACK----TSTHKAQTLAASILNISRS 1335
++ +KE + EL + K D K K + +++ +S
Sbjct: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
Query: 1336 DLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQ--LPFASYLLEAVLEKINEKKK 1393
I++ ED + + +I++ N+ QK +E + + + E EK N K+
Sbjct: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKE 1582
Query: 1394 LVEGYFTIMKDI 1405
E T+ +
Sbjct: 1583 AEEKILTLENQV 1594
Score = 124 bits (312), Expect = 5e-28
Identities = 191/837 (22%), Positives = 355/837 (42%), Gaps = 158/837 (18%)
Query: 85 GSRRLEGISVEEAMVTRTQLLEEELSS-------LKEELALCQADKEFVWSLWKRLQVTN 137
G + + S +E+ +T+ L++ELS +KEEL + K + SL K+L N
Sbjct: 1327 GGNQQQAASEKESCITQ---LKKELSENINAVTLMKEEL---KEKKVEISSLSKQLTDLN 1380
Query: 138 PDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAV 197
L +SL EK+ + + RK Q + K + +Q + L +++ L K KI+
Sbjct: 1381 VQLQNSISL---SEKEAAISSLRK-----QYDEEKCELLDQVQD-LSFKVDTLSKEKISA 1431
Query: 198 DEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQ-----------NKEEQNRLVIKNLEEE 246
E+ +FS+ +KK + + + ++T + +Q K+EQ L+ + L+++
Sbjct: 1432 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 247 NKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNAL 306
NK+ ++ +D K+ K+E++L E S A+I ED++ + E+E
Sbjct: 1492 NKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNY 1551
Query: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNL--YKQNSTHTAQQAELIQQLQVLNMDTQK 364
+ Q + EL+QK LQ Q L K N A++ L + QV +M +
Sbjct: 1552 NQQKDIEHKELVQK----------LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAEL 1601
Query: 365 VLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLR-QSVTNLQDQLLQKEQENAKLK 423
+ +E H S+ ++ E K+ E L +S L + + EQ+ A +K
Sbjct: 1602 ETKKKELEHVNLSVKSKE---------EELKALEDRLESESAAKLAELKRKAEQKIAAIK 1652
Query: 424 EKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLS 483
++L L Q + + + LS L T + ++ E+ L+EKLK S
Sbjct: 1653 KQL---------LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQS 1703
Query: 484 ENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEK 543
E + + + T E + V+++ +K+ +R + EK
Sbjct: 1704 ETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE-------------EKISVLQRNLTEKEK 1750
Query: 544 ALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQL 603
LQ QE +E +H + R Q + + + KQ E+ S + ++ ++L
Sbjct: 1751 LLQRVGQEKEETVSSHFEM--RCQYQERLIKLEHAEAKQHEDQSMIGHLQ-------EEL 1801
Query: 604 RQEDSDAVWNELAYFKRENQELMIQ-KMNLE-------EELDELKVHISIDKAAIQELNR 655
+++ + ++E + IQ K NLE + L E ++ I + I+EL+
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS 1861
Query: 656 CVAERRE------EQLF--------------RSGEDDEVKRSTPEKNGKEMLEQTL---- 691
C+ ++E E+L R+ + ++ +T EK+ +++ L
Sbjct: 1862 CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNM 1921
Query: 692 -QKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQ----- 745
+ +LE +L E+ +KL + +L K+ L+ L K+ Q++ E +KE +Q
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKD---LRMLRKEHQQELEILKKEYDQEREEK 1978
Query: 746 IIKGSKDVEKE------------NTELQVKISELETEV--TSLRRQVAEANALRNENEEL 791
I + +D+E + NT+L K ELE + T + Q EA L + EE
Sbjct: 1979 IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEET 2038
Query: 792 INPMEKSHQSAD-------------RAKSEMATMKVRSGRYDCKTTMTKVKFKAAKK 835
++K + D A+ E T KVR D +T + +++ K +K
Sbjct: 2039 NQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVR----DLQTQLEELQKKYQQK 2091
Score = 116 bits (290), Expect = 2e-25
Identities = 238/1139 (20%), Positives = 487/1139 (42%), Gaps = 138/1139 (12%)
Query: 307 SLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDT--QK 364
SL S+ + L++ +L R +L + S ++ +L+ LN + Q+
Sbjct: 83 SLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQR 142
Query: 365 VLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKE 424
+ R + + SY+ Y+EL ++ + + L+ ++ QD+ L++ A+L+E
Sbjct: 143 LRRMERSLS-----SYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRI---AELRE 194
Query: 425 KLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLM-------------------VSQK 465
+LQ Q A L +E D + + L + +L+ + +
Sbjct: 195 ELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQ 254
Query: 466 SEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDS 525
+E+ +E + E + E+ G S K++ T + VKR +L + T
Sbjct: 255 AEVFTKEENPESDGEPVVED-----GTSVKTLETLQQR------VKRQENLLKRCKETIQ 303
Query: 526 EELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEE 585
++ + E L++ L + QE ++++D H K + L T R K ++Q E+
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTK---LITQLRDAKNLIEQLEQ 360
Query: 586 GSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISI 645
GM I + KR + L ++ E+A + +++ Q L E+ ++
Sbjct: 361 DKGMV-IAETKRQMHETLEMKE-----EEIAQLRSRIKQMTTQGEELREQKEK------S 408
Query: 646 DKAAIQELNRCV--AERREE--QLFRSGEDDEVKRSTPEKNGKE---MLEQTLQKVTE-- 696
++AA +EL + + A++ EE + ++ D+++K T EK +E L+Q L +V +
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIK--TIEKTSEEERISLQQELSRVKQEV 466
Query: 697 LENRLKSFEKRSRKLKEGNKKLM--KENDFLKSLLKQQQEDTE----TREKELEQIIKGS 750
++ KS E++ KL++ ++K + KE + K L +++E E EK + +K S
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526
Query: 751 KDVEK------ENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADR 804
++ E+ E ELQ K E+E LR EA R EL + +EKS Q
Sbjct: 527 QEKEQQESLALEELELQKKAILTESE-NKLRDLQQEAETYRTRILELESSLEKSLQENKN 585
Query: 805 AKSEMAT-MKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVF----EN 859
++A ++ +++ + T+ K K ++ + + ++V+ + E
Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK-HQQDALWTEKLQVLKQQYQTEMEK 644
Query: 860 LSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEI 919
L + ++ D E + + +T +K+ + + S+ +E + + K
Sbjct: 645 LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK-- 702
Query: 920 VQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSS 979
++ L++ + AK ++KN Q+ V+ ++ + + +
Sbjct: 703 LEEELSVLKDQTDKMKQELEAKMD--EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
Query: 980 NIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKL---LHQQQVSDQRFQTSRQT 1036
+LL+ER L++ + ++N + + S E ++ + KL Q + ++ + +
Sbjct: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
Query: 1037 IKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEE-NSQVTFPRIQVTSLSPSRSMDLEMK 1095
+ +L L L E+ L K++ +E+ + ++ +++ +IQV L + ++ +
Sbjct: 821 LAQLQQKLLDLETERILLTKQV---AEVEAQKKDVCTELDAHKIQVQDL--MQQLEKQNS 875
Query: 1096 QLQYKLKNAT----NELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIE 1151
+++ K+K+ T ++L + + K L+ KE I +M E + +T K E
Sbjct: 876 EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE 935
Query: 1152 DLKFRQKVNLESN-KSFSEMLQNLDKKVKTLTEECSNKKVSIDS-LKQRLNVAVKEKSQY 1209
D E+ K+ + ++ + +K K + E K + ++ LK+ L E SQ
Sbjct: 936 DSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQK 995
Query: 1210 EQMYQ-KSKEELEKKDLKLTLLVSRI---------SETESAMAEIETAAS---------- 1249
E+ + K E + ++ VSR+ S TE E+ S
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 1250 ---KQLQELALQ--SEQVLEGAQKTLLLANEKVEEFTTFVKALAKE-LQNDVHVVRRQIR 1303
+++ E+ LQ ++V E QK LL EK EE + L +E ++ D +
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEK-EEMNKEITWLKEEGVKQDT-----TLN 1109
Query: 1304 ELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEIL--DTEDQVEIEKTKIDAENDK 1360
EL++ K + A S + +T + L DL + L +T Q ++ + K+ AE DK
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
Score = 50.8 bits (120), Expect = 9e-06
Identities = 79/397 (19%), Positives = 161/397 (40%), Gaps = 41/397 (10%)
Query: 991 LQQQNSVLQNA-KKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRK 1049
LQ++ LQ ++ + S++ E+ E+L Q +Q K L + +
Sbjct: 167 LQREKKKLQGILSQSQDKSLRRIAELREEL-----------QMDQQAKKHLQEEFDASLE 215
Query: 1050 EKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELT 1109
EK+ + L++ + N + + V P E+ + ++ +
Sbjct: 216 EKDQYISVLQTQVSLLKQRLRNGPMN---VDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272
Query: 1110 KQSSNVKTLKF---ELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKS 1166
+ ++VKTL+ + +E +K E I + T+ E L+ + L+ +
Sbjct: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 332
Query: 1167 FSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLK 1226
++ ++ +K K +T+ K + I+ L+Q + + E + QM+ E LE K+ +
Sbjct: 333 IKDL--HMAEKTKLITQLRDAKNL-IEQLEQDKGMVIAETKR--QMH----ETLEMKEEE 383
Query: 1227 LTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKT----LLLANEKVEEFTT 1282
+ L SRI + + E+ K + + E+ L AQKT L E E+ T
Sbjct: 384 IAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT 443
Query: 1283 FVKALAKE---LQNDVHVVRRQIRELKKMKKNRDACKTS-------THKAQTLAASILNI 1332
K +E LQ ++ V++++ ++ K K K Q L +
Sbjct: 444 IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503
Query: 1333 SRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKL 1369
R E++ ++ + E KI E +++ L +++L
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQESLALEEL 540
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 140 bits (353), Expect = 9e-33
Identities = 238/1195 (19%), Positives = 499/1195 (41%), Gaps = 142/1195 (11%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 873
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 874 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 929
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 990 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 343 THTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTK----SNE 398
H + +EL +L+ Q++ + + + ++ + + +L K E
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 399 AMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458
L+ ++ L D++ QK N LK K++E +G L ++ D + +A+ L
Sbjct: 1097 EELQAALARLDDEIAQK---NNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 459 TLMVSQKSEIEYLQEKLKIANE---KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRS 515
+ + K+E+E + E K + ++ K K++ E + E V+ R
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KAL--DEETRSHEAQVQEMRQ 1206
Query: 516 LSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRA 575
++ +E+L++ ++A+ NL+K Q +EN +L + Q ++ +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKA---NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 576 VKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEE 635
++ Q+++ + E + + D Q + ++V L + + +L +L +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 636 LDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVT 695
L + + + + Q+LN R+ E+ S +D + ++N + + +++
Sbjct: 1324 LQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 696 ELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
+ + +L+ F L+EG K+ KE +++L +Q +E +K +EK
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKE---IENLTQQYEEKAAAYDK-----------LEK 1427
Query: 756 ENTELQVKISELETEVTSLRRQVAEANALRNENEELI----NPMEKSHQSADRAKSEMAT 811
LQ ++ +L ++ + R+ V+ + + ++L+ N K DRA++E
Sbjct: 1428 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 812 MKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSES 871
+ ++ ++ + +A + + R + +L ++ + + SKD DV ++
Sbjct: 1488 KETKA------LSLARALEEALEAKEELERTNKMLKAEMEDLVS-----SKD---DVGKN 1533
Query: 872 SSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTP 931
+ E ++ + L T + E ++ ED E TED++ + L ++ +
Sbjct: 1534 VHELE-KSKRALETQMEEMKTQLEELED-----ELQATEDAKLR--------LEVNMQAL 1579
Query: 932 KDYFH-DKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIIS 990
K F D A+ ++K ++Q+ H + K + + A L++ +
Sbjct: 1580 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1639
Query: 991 LQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK----------L 1040
+ A K + K+ +L + D+ F T+++ KK L
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699
Query: 1041 NLDLAGLRK-------EKEDLLKKLESS-SEITSLAEENSQVTFPRIQVTSLSPSRSMDL 1092
DLA + EKE+L ++L SS S +L +E ++ Q+ ++
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759
Query: 1093 E-----MKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKR 1147
E +++ + + +NEL + S + + E KE+ K+ ME + K
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK- 1818
Query: 1148 HLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE----ECSNKKVSIDSLKQ---RLN 1200
F + L+ K+ L E E K+ + SLKQ +L
Sbjct: 1819 -------------------FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 1201 VAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQEL 1255
+ + +M ++ KE+ EK + ++ L ++ E E I K +EL
Sbjct: 1860 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 104 bits (259), Expect = 7e-22
Identities = 162/846 (19%), Positives = 340/846 (40%), Gaps = 104/846 (12%)
Query: 556 RDAHEKRKERLQMLQTNYR--AVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWN 613
R A KR+++L ++ R A +L+ W+ T+++ + + Q+ E+ A +
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE---EEMQAKED 866
Query: 614 ELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDE 673
EL K Q+ + LE++ +L + +K +QE + E +L+ E+
Sbjct: 867 ELQKTKERQQKAENELKELEQKHSQL----TEEKNLLQEQLQA-----ETELYAEAEEMR 917
Query: 674 VKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKL----------MKEND 723
V+ + ++ +E+L E+E RL+ E R ++L+ KK+ ++E +
Sbjct: 918 VRLAAKKQELEEILH-------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 724 FLKSLLKQQQEDTETREKELEQIIKGSKD----VEKENTELQVKISELETEVTSLRRQVA 779
+ L+ ++ E + K+LE I D + KE L+ +IS+L T + +
Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 780 EANALRNENEELINPMEKSHQSADRAKSEMATMKVR---------SGRYDCKTTMTKVKF 830
L+N++E +I+ +E + ++++ E+ +K + D + + ++K
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 831 KAAKKNCSVGRHHTVLNHSIKVMSNVFENLSK-DGWEDVSESSSDSEAQTSQTLGTIIVE 889
+ AKK + L+ I +N + + + +G +S+ D +++ +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEG--HISDLQEDLDSERA--------- 1139
Query: 890 TSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKN 949
+ ++++ D E+ + E+ T +D + K ++ T KK
Sbjct: 1140 -------ARNKAEKQKRDLGEELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKA 1189
Query: 950 CKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSV 1009
+ SH A + QK + + L E++ ++ + L K+T E
Sbjct: 1190 LDEETRSHEAQVQEMR---------QKHAQAVEELTEQLEQFKRAKANLDKNKQTLE--- 1237
Query: 1010 KEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLK-KLESSSEITSLA 1068
+ N L + +V Q Q KKL + L+ + D + + E + ++ L
Sbjct: 1238 ----KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 1069 EENSQVTFPRIQVTSLSPSRSMDL-----EMKQLQYKLKNATNELTKQSSNVKTLKFELL 1123
E VT + + + D+ +++ Q L+ T + S+ ++ L+ E
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 1124 AKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE 1183
+ ++ + E E +ER I+ + D K + + + ++ E + K+++ LT+
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 1184 ECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKE---ELEKKDLKLTLLVSR------- 1233
+ K + D L++ N +E ++ LEKK K L++
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 1234 -ISETESAMAEIETAASKQLQ-----ELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL 1287
E + A AE +K L E AL++++ LE K L E + V
Sbjct: 1474 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 1288 AKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQV 1347
EL+ + Q+ E+K + + +T A+ + + E L D+
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 1348 EIEKTK 1353
EK +
Sbjct: 1594 NEEKRR 1599
Score = 102 bits (253), Expect = 3e-21
Identities = 158/880 (17%), Positives = 364/880 (41%), Gaps = 73/880 (8%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
+ + + L+ L+ L +E+A + + L + DL + + EKQK +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 158 KDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
+ +++D Q+E K+E V +K A+DEE + ++ +K
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEMRQKHAQ 1210
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+E+ + + EQ + NL++ + L DL +L L + + + +K
Sbjct: 1211 AVEELTE-------QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 278 TDAKIKTFEDNLIEARK-------EVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKE 330
+A+++ + + + +V Q++ +++ L+ + + I+ D+ + +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 331 LQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHIC 390
LQ+ Q L ++ + + ++QL+ + + L++Q D + ++ + L+I
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLE----EERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 391 FETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPH 450
+K +V L++ + ++E L ++ +E A L + +
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR-------L 1432
Query: 451 RPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPV 510
+ L L + +Q+ + L++K + ++ L+E + + ++ + AE + KE
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE--- 1489
Query: 511 KRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQ-LKSQENDELRDAHEKRKERLQML 569
+++LS + E L+ + ER + L+ ++ L S ++D ++ HE K + + L
Sbjct: 1490 --TKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RAL 1544
Query: 570 QTNYRAVKEQLKQWEEGSGMTEIRKIK-RADPQQLRQEDSDAVWNELAYFKRENQELMIQ 628
+T +K QL++ E+ TE K++ + Q L+ + + + + ++L Q
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 629 KMNLEEELDELKVHISIDKAAIQELNRCVAERR-EEQLFRSGEDDEVKR----STPEKNG 683
E EL++ + ++ AA ++L + + + G ++ +K+ K+
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1664
Query: 684 KEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKEL 743
+ LE E+ K EK+++ L+ +L ++ + KQ + E +EL
Sbjct: 1665 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Query: 744 EQIIKGSKDVEKENTELQVKISELETEVTS-----------LRRQVAEANALRNENEELI 792
+ G ++ E L+ +I++LE E+ +R+ +A L NE
Sbjct: 1725 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1784
Query: 793 NPMEKSHQSADRAKSEMATMKVRSGRYDC--------KTTMTKVKFKAAKKNCSV---GR 841
+ +K+ + R + E ++RS ++ K+T+ ++ K A+ V R
Sbjct: 1785 STAQKNESA--RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 842 HHTVLNHSIKVMSNVFENL------SKDGWEDVSESSSDSEAQTSQTLGTI--IVETSQK 893
S+K + + + E E + A+ Q + E SQ+
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 894 ISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKD 933
I+ ++ + TE ++ G+E+ + G P++
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1942
Score = 97.1 bits (240), Expect = 1e-19
Identities = 204/992 (20%), Positives = 399/992 (40%), Gaps = 143/992 (14%)
Query: 103 QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKV 162
+LLEE +S L LA ++E +L K + N + + L V + K E K R+
Sbjct: 1009 KLLEERISDLTTNLA---EEEEKAKNLTK---LKNKHESMISELEV---RLKKEEKSRQE 1059
Query: 163 LEILQVK-DAKIQEFEQRESVLKQEINDLVKRKIAVDEEN---AFLR------------K 206
LE L+ K + +F ++ + L+ +I +L K ++A EE A R K
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLN------D 260
+ +LE D +++ D++ +NK E+ + ++L EE + L T D L+ +
Sbjct: 1119 KIRELEGHISDLQEDL-DSERAARNKAEKQK---RDLGEELEALKTELEDTLDSTATQQE 1174
Query: 261 LEKLRKQEAHLRK-----EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQT 315
L R+QE + K E S +A+++ +A +E+ ++ L +
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 316 ELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAEL-IQQLQVLNMDTQKVLRNQED-VH 373
L +++ D+ EL+ L KQ H ++ E +Q+LQ D ++ D VH
Sbjct: 1235 TLEKENADLA---GELRVLGQA-KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 374 TAESI--SYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQG 431
++ S + NE + A L + + Q+ L ++ ++ + KL++ +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 432 APLPLPQESDPDYSAQVPHRPSLSSLETLMVSQK-------SEIEYLQEKLKIANEKLSE 484
L + D + A+ +S+L + K S +E L+E K +++ E
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI-E 1409
Query: 485 NISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEE--LQKLRKAERKIENL- 541
N++ + K+ +A K ++ + + L D++ + L K +RK + L
Sbjct: 1410 NLTQQ--YEEKA---AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 542 --EKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRAD 599
EK + K + + +A + KE + RA++E L+ EE + K+ +A+
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLA--RALEEALEAKEE---LERTNKMLKAE 1519
Query: 600 PQQLRQEDSDAVWN--ELAYFKR----ENQELMIQKMNLEEEL---DELKVHISIDKAAI 650
+ L D N EL KR + +E+ Q LE+EL ++ K+ + ++ A+
Sbjct: 1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Query: 651 QELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRK 710
+ + R+EQ +E KR +++ Q + TELE+ E++ R
Sbjct: 1580 KGQFERDLQARDEQ-------NEEKR-------RQLQRQLHEYETELED-----ERKQRA 1620
Query: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
L KK + + D + E + + IKG ++ K+ +LQ ++ + + E
Sbjct: 1621 LAAAAKKKL-------------EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 771 VTSLRRQVAEANALRNENEELINPMEKS--HQSADRAKSEMATMKVRSGRYDCKTTMTKV 828
+ R E A ENE+ +E D A +E A + + K
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---------QADLEKE 1718
Query: 829 KFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIV 888
+ + GR N +D + + E + + G +
Sbjct: 1719 ELAEELASSLSGR-----------------NALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 889 ETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKK 948
+ + T+ + TE S Q E + L K + H+ + K
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 949 NCKMQKSSHTAVPTRVNREKYKNITAQKS-SSNIILLRERIISLQQQNSVLQNAKKTAEL 1007
++ + +V +E + A KS L+E ++ ++ + + + K+ AE
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 1008 SVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK 1039
K++ +L ++ S QR +R+ +++
Sbjct: 1882 GNARVKQLKRQLEEAEEES-QRINANRRKLQR 1912
Score = 91.3 bits (225), Expect = 6e-18
Identities = 199/960 (20%), Positives = 375/960 (39%), Gaps = 142/960 (14%)
Query: 526 EELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKE------- 578
+ELQK ++ ++K EN K L+ Q++ +L + +E+LQ Y +E
Sbjct: 866 DELQKTKERQQKAENELKELE---QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 579 QLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKR--ENQELMIQKMNLEEEL 636
+ ++ EE E R + D Q Q + + ++ + E +E QK+ LE+
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982
Query: 637 DELKVHISIDKAAIQE--LNRCVAERR--EEQLFR-----SGEDDEVKRSTPEKNGKEML 687
E K+ D+ + + N+ ER+ EE++ + E+++ K T KN E +
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 688 EQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE-NDFLKSLLKQQQEDTETR------E 740
++ELE RLK EK ++L++ +KL + +DF + + Q + E + E
Sbjct: 1043 ------ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 741 KELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQ 800
+EL+ + D + KI ELE ++ L+ + A RN+ E+ Q
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---------Q 1147
Query: 801 SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENL 860
D + A D T +++ K ++ + V+ +
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--------------VTVLKKALDEE 1193
Query: 861 SKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIV 920
++ V E AQ + L + + + + + K E E++ G+
Sbjct: 1194 TRSHEAQVQEMRQ-KHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE--- 1246
Query: 921 QTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKN----ITAQ- 975
L + G+ ++ H K + Q+ K K +N +T
Sbjct: 1247 ---LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 976 -KSSSNIILLRERIISLQQQ----NSVLQNA---KKTAELSVKEYKEVNEKLLHQQQVSD 1027
++ I L + + SL Q +LQ K +++ +E L Q
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 1028 QRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPS 1087
+ Q + I LN+ L+ +K+ +D +E+ E ++ + + + + +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 1088 RSMDLEMKQLQYKLKNATNELTKQSSNVKTL-----KFE-LLAKEEHIKEMH-EKISRME 1140
+ ++ +LQ +L + +L Q V L KF+ LLA+E++I + ++ R E
Sbjct: 1424 K-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 1141 RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLN 1200
+ K L + LE+ E L+ +K +K E+ + K D + + ++
Sbjct: 1483 AEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDLVSSK---DDVGKNVH 1535
Query: 1201 VAVKEKSQYEQMYQKSKEELEK--------KDLKLTL------LVSRISETESAMAEIET 1246
K K E ++ K +LE+ +D KL L L + A E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 1247 AASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQ----- 1301
+QLQ + E LE +K LA ++ +K L ELQ D + R+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQ 1653
Query: 1302 -----------IRELKKMKKNRD----ACKTSTHKAQTLAASILNISRSDLEEILDTEDQ 1346
REL+ + +RD K + KA++L A ++ + + DL Q
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARKQ 1712
Query: 1347 VEIEKTKIDAENDKEWMLYIQKLLEGQ--LPFASYLLEAVLEKINEKKKLVEGYFTIMKD 1404
++EK ++ E + L G+ L LEA + ++ E+ + +G M D
Sbjct: 1713 ADLEKEELAEE--------LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 140 bits (353), Expect = 9e-33
Identities = 238/1195 (19%), Positives = 499/1195 (41%), Gaps = 142/1195 (11%)
Query: 106 EEELSSLKEELALCQADKEFV-WSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
+++L+++K C A + W W+ P L QV E E Q E + +K E
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKP-LLQVTRQ--EEEMQAKEDELQKTKE 866
Query: 165 ILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
Q + +++E EQ+ S L +E N L++ ++ + E L E ++ + K QE+++
Sbjct: 867 RQQKAENELKELEQKHSQLTEEKN-LLQEQLQAETE---LYAEAEEMRVRLAAKKQELEE 922
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKT 284
++ + E+ + L+ E KK++ + DL LE+ L+ EK + +AKIK
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 285 FEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD--ITLVRKELQELQNLYKQNS 342
ED E+ V + N LS K+ +L+++ + T + +E ++ +NL K +
Sbjct: 983 LED-------EILVMDDQNNKLS-----KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 343 THTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTK----SNE 398
H + +EL +L+ Q++ + + + ++ + + +L K E
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLE-GDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 399 AMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLE 458
L+ ++ L D++ QK N LK K++E +G L ++ D + +A+ L
Sbjct: 1090 EELQAALARLDDEIAQK---NNALK-KIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 459 TLMVSQKSEIEYLQEKLKIANE---KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRS 515
+ + K+E+E + E K + ++ K K++ E + E V+ R
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KAL--DEETRSHEAQVQEMRQ 1199
Query: 516 LSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRA 575
++ +E+L++ ++A+ NL+K Q +EN +L + Q ++ +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKA---NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 576 VKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEE 635
++ Q+++ + E + + D Q + ++V L + + +L +L +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 636 LDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVT 695
L + + + + Q+LN R+ E+ S +D + ++N + + +++
Sbjct: 1317 LQDTQE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 696 ELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEK 755
+ + +L+ F L+EG K+ KE +++L +Q +E +K +EK
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKE---IENLTQQYEEKAAAYDK-----------LEK 1420
Query: 756 ENTELQVKISELETEVTSLRRQVAEANALRNENEELI----NPMEKSHQSADRAKSEMAT 811
LQ ++ +L ++ + R+ V+ + + ++L+ N K DRA++E
Sbjct: 1421 TKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 812 MKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSES 871
+ ++ ++ + +A + + R + +L ++ + + SKD DV ++
Sbjct: 1481 KETKA------LSLARALEEALEAKEELERTNKMLKAEMEDLVS-----SKD---DVGKN 1526
Query: 872 SSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTP 931
+ E ++ + L T + E ++ ED E TED++ + L ++ +
Sbjct: 1527 VHELE-KSKRALETQMEEMKTQLEELED-----ELQATEDAKLR--------LEVNMQAL 1572
Query: 932 KDYFH-DKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIIS 990
K F D A+ ++K ++Q+ H + K + + A L++ +
Sbjct: 1573 KGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ 1632
Query: 991 LQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK----------L 1040
+ A K + K+ +L + D+ F T+++ KK L
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692
Query: 1041 NLDLAGLRK-------EKEDLLKKLESS-SEITSLAEENSQVTFPRIQVTSLSPSRSMDL 1092
DLA + EKE+L ++L SS S +L +E ++ Q+ ++
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752
Query: 1093 E-----MKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKR 1147
E +++ + + +NEL + S + + E KE+ K+ ME + K
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK- 1811
Query: 1148 HLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE----ECSNKKVSIDSLKQ---RLN 1200
F + L+ K+ L E E K+ + SLKQ +L
Sbjct: 1812 -------------------FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 1201 VAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQEL 1255
+ + +M ++ KE+ EK + ++ L ++ E E I K +EL
Sbjct: 1853 EILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 104 bits (259), Expect = 7e-22
Identities = 162/846 (19%), Positives = 340/846 (40%), Gaps = 104/846 (12%)
Query: 556 RDAHEKRKERLQMLQTNYR--AVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWN 613
R A KR+++L ++ R A +L+ W+ T+++ + + Q+ E+ A +
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE---EEMQAKED 859
Query: 614 ELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDE 673
EL K Q+ + LE++ +L + +K +QE + E +L+ E+
Sbjct: 860 ELQKTKERQQKAENELKELEQKHSQL----TEEKNLLQEQLQA-----ETELYAEAEEMR 910
Query: 674 VKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKL----------MKEND 723
V+ + ++ +E+L E+E RL+ E R ++L+ KK+ ++E +
Sbjct: 911 VRLAAKKQELEEILH-------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 724 FLKSLLKQQQEDTETREKELEQIIKGSKD----VEKENTELQVKISELETEVTSLRRQVA 779
+ L+ ++ E + K+LE I D + KE L+ +IS+L T + +
Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 780 EANALRNENEELINPMEKSHQSADRAKSEMATMKVR---------SGRYDCKTTMTKVKF 830
L+N++E +I+ +E + ++++ E+ +K + D + + ++K
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 831 KAAKKNCSVGRHHTVLNHSIKVMSNVFENLSK-DGWEDVSESSSDSEAQTSQTLGTIIVE 889
+ AKK + L+ I +N + + + +G +S+ D +++ +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEG--HISDLQEDLDSERA--------- 1132
Query: 890 TSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKN 949
+ ++++ D E+ + E+ T +D + K ++ T KK
Sbjct: 1133 -------ARNKAEKQKRDLGEELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKA 1182
Query: 950 CKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSV 1009
+ SH A + QK + + L E++ ++ + L K+T E
Sbjct: 1183 LDEETRSHEAQVQEMR---------QKHAQAVEELTEQLEQFKRAKANLDKNKQTLE--- 1230
Query: 1010 KEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLK-KLESSSEITSLA 1068
+ N L + +V Q Q KKL + L+ + D + + E + ++ L
Sbjct: 1231 ----KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 1069 EENSQVTFPRIQVTSLSPSRSMDL-----EMKQLQYKLKNATNELTKQSSNVKTLKFELL 1123
E VT + + + D+ +++ Q L+ T + S+ ++ L+ E
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 1124 AKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE 1183
+ ++ + E E +ER I+ + D K + + + ++ E + K+++ LT+
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 1184 ECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKE---ELEKKDLKLTLLVSR------- 1233
+ K + D L++ N +E ++ LEKK K L++
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 1234 -ISETESAMAEIETAASKQLQ-----ELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL 1287
E + A AE +K L E AL++++ LE K L E + V
Sbjct: 1467 YADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 1288 AKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQV 1347
EL+ + Q+ E+K + + +T A+ + + E L D+
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 1348 EIEKTK 1353
EK +
Sbjct: 1587 NEEKRR 1592
Score = 102 bits (253), Expect = 3e-21
Identities = 158/880 (17%), Positives = 364/880 (41%), Gaps = 73/880 (8%)
Query: 98 MVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEA 157
+ + + L+ L+ L +E+A + + L + DL + + EKQK +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 158 KDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKD 217
+ +++D Q+E K+E V +K A+DEE + ++ +K
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQEMRQKHAQ 1203
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYS 277
+E+ + + EQ + NL++ + L DL +L L + + + +K
Sbjct: 1204 AVEELTE-------QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 278 TDAKIKTFEDNLIEARK-------EVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKE 330
+A+++ + + + +V Q++ +++ L+ + + I+ D+ + +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 331 LQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHIC 390
LQ+ Q L ++ + + ++QL+ + + L++Q D + ++ + L+I
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLE----EERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 391 FETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPH 450
+K +V L++ + ++E L ++ +E A L + +
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR-------L 1425
Query: 451 RPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPV 510
+ L L + +Q+ + L++K + ++ L+E + + ++ + AE + KE
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE--- 1482
Query: 511 KRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQ-LKSQENDELRDAHEKRKERLQML 569
+++LS + E L+ + ER + L+ ++ L S ++D ++ HE K + + L
Sbjct: 1483 --TKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RAL 1537
Query: 570 QTNYRAVKEQLKQWEEGSGMTEIRKIK-RADPQQLRQEDSDAVWNELAYFKRENQELMIQ 628
+T +K QL++ E+ TE K++ + Q L+ + + + + ++L Q
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 629 KMNLEEELDELKVHISIDKAAIQELNRCVAERR-EEQLFRSGEDDEVKR----STPEKNG 683
E EL++ + ++ AA ++L + + + G ++ +K+ K+
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF 1657
Query: 684 KEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKEL 743
+ LE E+ K EK+++ L+ +L ++ + KQ + E +EL
Sbjct: 1658 QRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Query: 744 EQIIKGSKDVEKENTELQVKISELETEVTS-----------LRRQVAEANALRNENEELI 792
+ G ++ E L+ +I++LE E+ +R+ +A L NE
Sbjct: 1718 ASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER 1777
Query: 793 NPMEKSHQSADRAKSEMATMKVRSGRYDC--------KTTMTKVKFKAAKKNCSV---GR 841
+ +K+ + R + E ++RS ++ K+T+ ++ K A+ V R
Sbjct: 1778 STAQKNESA--RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 842 HHTVLNHSIKVMSNVFENL------SKDGWEDVSESSSDSEAQTSQTLGTI--IVETSQK 893
S+K + + + E E + A+ Q + E SQ+
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 894 ISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKD 933
I+ ++ + TE ++ G+E+ + G P++
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1935
Score = 97.1 bits (240), Expect = 1e-19
Identities = 204/992 (20%), Positives = 399/992 (40%), Gaps = 143/992 (14%)
Query: 103 QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKV 162
+LLEE +S L LA ++E +L K + N + + L V + K E K R+
Sbjct: 1002 KLLEERISDLTTNLA---EEEEKAKNLTK---LKNKHESMISELEV---RLKKEEKSRQE 1052
Query: 163 LEILQVK-DAKIQEFEQRESVLKQEINDLVKRKIAVDEEN---AFLR------------K 206
LE L+ K + +F ++ + L+ +I +L K ++A EE A R K
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLN------D 260
+ +LE D +++ D++ +NK E+ + ++L EE + L T D L+ +
Sbjct: 1112 KIRELEGHISDLQEDL-DSERAARNKAEKQK---RDLGEELEALKTELEDTLDSTATQQE 1167
Query: 261 LEKLRKQEAHLRK-----EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQT 315
L R+QE + K E S +A+++ +A +E+ ++ L +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 316 ELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAEL-IQQLQVLNMDTQKVLRNQED-VH 373
L +++ D+ EL+ L KQ H ++ E +Q+LQ D ++ D VH
Sbjct: 1228 TLEKENADLA---GELRVLGQA-KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 374 TAESI--SYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQG 431
++ S + NE + A L + + Q+ L ++ ++ + KL++ +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 432 APLPLPQESDPDYSAQVPHRPSLSSLETLMVSQK-------SEIEYLQEKLKIANEKLSE 484
L + D + A+ +S+L + K S +E L+E K +++ E
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI-E 1402
Query: 485 NISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEE--LQKLRKAERKIENL- 541
N++ + K+ +A K ++ + + L D++ + L K +RK + L
Sbjct: 1403 NLTQQ--YEEKA---AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 542 --EKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRAD 599
EK + K + + +A + KE + RA++E L+ EE + K+ +A+
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLA--RALEEALEAKEE---LERTNKMLKAE 1512
Query: 600 PQQLRQEDSDAVWN--ELAYFKR----ENQELMIQKMNLEEEL---DELKVHISIDKAAI 650
+ L D N EL KR + +E+ Q LE+EL ++ K+ + ++ A+
Sbjct: 1513 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Query: 651 QELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRK 710
+ + R+EQ +E KR +++ Q + TELE+ E++ R
Sbjct: 1573 KGQFERDLQARDEQ-------NEEKR-------RQLQRQLHEYETELED-----ERKQRA 1613
Query: 711 LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETE 770
L KK + + D + E + + IKG ++ K+ +LQ ++ + + E
Sbjct: 1614 LAAAAKKKL-------------EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 771 VTSLRRQVAEANALRNENEELINPMEKS--HQSADRAKSEMATMKVRSGRYDCKTTMTKV 828
+ R E A ENE+ +E D A +E A + + K
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK---------QADLEKE 1711
Query: 829 KFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIV 888
+ + GR N +D + + E + + G +
Sbjct: 1712 ELAEELASSLSGR-----------------NALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 889 ETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKK 948
+ + T+ + TE S Q E + L K + H+ + K
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 949 NCKMQKSSHTAVPTRVNREKYKNITAQKS-SSNIILLRERIISLQQQNSVLQNAKKTAEL 1007
++ + +V +E + A KS L+E ++ ++ + + + K+ AE
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 1008 SVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK 1039
K++ +L ++ S QR +R+ +++
Sbjct: 1875 GNARVKQLKRQLEEAEEES-QRINANRRKLQR 1905
Score = 91.3 bits (225), Expect = 6e-18
Identities = 199/960 (20%), Positives = 375/960 (39%), Gaps = 142/960 (14%)
Query: 526 EELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKE------- 578
+ELQK ++ ++K EN K L+ Q++ +L + +E+LQ Y +E
Sbjct: 859 DELQKTKERQQKAENELKELE---QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 579 QLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKR--ENQELMIQKMNLEEEL 636
+ ++ EE E R + D Q Q + + ++ + E +E QK+ LE+
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975
Query: 637 DELKVHISIDKAAIQE--LNRCVAERR--EEQLFR-----SGEDDEVKRSTPEKNGKEML 687
E K+ D+ + + N+ ER+ EE++ + E+++ K T KN E +
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 688 EQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE-NDFLKSLLKQQQEDTETR------E 740
++ELE RLK EK ++L++ +KL + +DF + + Q + E + E
Sbjct: 1036 ------ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 741 KELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQ 800
+EL+ + D + KI ELE ++ L+ + A RN+ E+ Q
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK---------Q 1140
Query: 801 SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENL 860
D + A D T +++ K ++ + V+ +
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQE--------------VTVLKKALDEE 1186
Query: 861 SKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIV 920
++ V E AQ + L + + + + + K E E++ G+
Sbjct: 1187 TRSHEAQVQEMRQ-KHAQAVEELTEQLEQFKRAKANLDKNKQTLEK---ENADLAGE--- 1239
Query: 921 QTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKN----ITAQ- 975
L + G+ ++ H K + Q+ K K +N +T
Sbjct: 1240 ---LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 976 -KSSSNIILLRERIISLQQQ----NSVLQNA---KKTAELSVKEYKEVNEKLLHQQQVSD 1027
++ I L + + SL Q +LQ K +++ +E L Q
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 1028 QRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPS 1087
+ Q + I LN+ L+ +K+ +D +E+ E ++ + + + + +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 1088 RSMDLEMKQLQYKLKNATNELTKQSSNVKTL-----KFE-LLAKEEHIKEMH-EKISRME 1140
+ ++ +LQ +L + +L Q V L KF+ LLA+E++I + ++ R E
Sbjct: 1417 K-LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 1141 RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLN 1200
+ K L + LE+ E L+ +K +K E+ + K D + + ++
Sbjct: 1476 AEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDLVSSK---DDVGKNVH 1528
Query: 1201 VAVKEKSQYEQMYQKSKEELEK--------KDLKLTL------LVSRISETESAMAEIET 1246
K K E ++ K +LE+ +D KL L L + A E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 1247 AASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQ----- 1301
+QLQ + E LE +K LA ++ +K L ELQ D + R+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL--ELQADSAIKGREEAIKQ 1646
Query: 1302 -----------IRELKKMKKNRD----ACKTSTHKAQTLAASILNISRSDLEEILDTEDQ 1346
REL+ + +RD K + KA++L A ++ + + DL Q
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARKQ 1705
Query: 1347 VEIEKTKIDAENDKEWMLYIQKLLEGQ--LPFASYLLEAVLEKINEKKKLVEGYFTIMKD 1404
++EK ++ E + L G+ L LEA + ++ E+ + +G M D
Sbjct: 1706 ADLEKEELAEE--------LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 138 bits (348), Expect = 3e-32
Identities = 234/1172 (19%), Positives = 472/1172 (40%), Gaps = 167/1172 (14%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ K E L +AK +E E++ L QE NDL + A + A +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
L K +IK+ E +++EE N L + +KL C++L D++ L
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDLEL 963
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
A + KEK++T+ K+K + + A + +++ +LQ +++QT
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEM--AGLDETIAKLTKEKKALQEAHQQT----------- 1010
Query: 327 VRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNE 386
L +LQ + +T T + +L QQ+ L ++ + D+ A+ +KL +
Sbjct: 1011 ----LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAK----RKLEGD 1062
Query: 387 LHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSA 446
L + E+T E +Q L ++L +KE E + L+ K+++ Q + L Q+ + A
Sbjct: 1063 LKLAQESTMDTENDKQQ----LNEKLKKKEFEMSNLQGKIEDEQALAIQL-QKKIKELQA 1117
Query: 447 QV--------PHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIM 498
++ R S + E E+E + E+L+ A S I NK R++
Sbjct: 1118 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEF 1175
Query: 499 TSAEGKHKEPPVKRSRSLSP-KSSFTDS-----EELQKLRKAERKIENLEKALQLKSQEN 552
+E ++ + + + DS E++ L++ ++K+E + L+++ +
Sbjct: 1176 QKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDL 1235
Query: 553 DELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR-------- 604
+ K K + + ++K EE + R I Q+ R
Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQLSEIKTKEE----EQQRLINELSAQKARLHTESGEF 1291
Query: 605 ---QEDSDAVWNELAYFKRE-NQELMIQKMNLEEE-----------------LDELKVHI 643
++ DA+ ++L+ K+ Q++ K LEEE D L+
Sbjct: 1292 SRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQY 1351
Query: 644 SIDKAAIQELNRCVAERREE--QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTE----L 697
++ A EL R +++ E Q E D ++R+ + K+ L Q LQ E +
Sbjct: 1352 EEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411
Query: 698 ENRLKSFEKRSRKLKEGNKKLM---------------KENDFLKSLLKQQQEDTETREKE 742
++ S EK ++L+ + LM K+ +F K L + +Q+ ET + E
Sbjct: 1412 NSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEET-QAE 1470
Query: 743 LEQIIKGSKDVEKE----NTELQVKISELET---EVTSLRRQVAEANALRNENEELINPM 795
LE K S+ + E + + LET E +L++++++ E + I+ +
Sbjct: 1471 LEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHEL 1530
Query: 796 EKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSN 855
EK + D KSE+ T + + ++ + K + + + + ++ I
Sbjct: 1531 EKVKKQLDHEKSELQT-----SLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDE 1585
Query: 856 VFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQ 915
+ L ++ V S +A+ + +I +G + + Q
Sbjct: 1586 ELDQLKRNHLRVVESMQSTLDAEIRSR------NDALRIKKKMEGDLNEMEIQLNHANRQ 1639
Query: 916 GKEIVQTYLNIDGKTPKDYFH---------DKNAKKPTFQKKNCKMQKSSHTAVPTRVNR 966
E ++ N G H D + +++ MQ +
Sbjct: 1640 AAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERT 1699
Query: 967 EKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVS 1026
E+ + + Q+ ++ ER+ L QN+ L N KK E + + + E ++
Sbjct: 1700 ERGRKMAEQE----LLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIV------ 1749
Query: 1027 DQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSP 1086
Q + + + KK D A + +E LKK + +S ++N + T +Q+
Sbjct: 1750 -QEARNAEEKAKKAITDAAMMAEE----LKKEQDTSAHLERMKKNMEQTVKDLQL----- 1799
Query: 1087 SRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMK 1146
R + E Q LK ++ K + V+ L+ E+ ++++H E + + + ER
Sbjct: 1800 -RLDEAE----QLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER----- 1849
Query: 1147 RHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEK 1206
+++L ++ + + ++ +++ L KVK + + + +N+A K
Sbjct: 1850 --RVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEE-----QSNVNLAKFRK 1902
Query: 1207 SQYEQMYQKSKEELEKKDLKLTLLVSRISETE 1238
Q+E K + ++ + + + SR T+
Sbjct: 1903 LQHELEEAKERADIAESQVNKLRVKSREVHTK 1934
Score = 124 bits (312), Expect = 5e-28
Identities = 231/1138 (20%), Positives = 449/1138 (39%), Gaps = 163/1138 (14%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
++EE KEELA +A ++ + L DL V + E D+ +
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKT 915
Query: 165 ILQVKDAKIQEFEQRESVLKQEIN-DLVKRKIAVDEENAFLRKEFSDL------------ 211
+Q+ +AKI+E +R ++EIN +L +K +++E + L+K+ DL
Sbjct: 916 KIQL-EAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 973
Query: 212 --EKKFKDKSQEIKDTKECVQNKEEQNRLV-----------------IKNLEEENKKLST 252
E K K+ ++E+ E + ++ + + + L + KL
Sbjct: 974 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQ 1033
Query: 253 RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSN 312
+ DL LE+ +K L + K + +K +++ ++ + + K ++SN
Sbjct: 1034 QVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSN 1093
Query: 313 KQTELIQKDMDITLVRKELQELQ----NLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRN 368
Q ++ + ++K+++ELQ L ++ A +A+ +Q L+ + +++
Sbjct: 1094 LQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 369 QEDVHTAES----------ISYQKLYNELHICFETTKSNEAMLRQ----SVTNLQDQLLQ 414
E+ A S +QK+ +L ++ A LR+ SV L +Q+
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDS 1213
Query: 415 KEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEK 474
++ KL+++ E + L + A+ +LE Q SEI+ +E+
Sbjct: 1214 LQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLE----DQLSEIKTKEEE 1269
Query: 475 LKIANEKLSENISANKG-FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDS-EELQKLR 532
++L +SA K +S S + K+ V S+ K +FT EEL++
Sbjct: 1270 ----QQRLINELSAQKARLHTESGEFSRQLDEKDAMV--SQLSRGKQAFTQQIEELKRQL 1323
Query: 533 KAERKIEN-LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWE------- 584
+ E K ++ L ALQ + D LR+ +E+ +E LQ ++ QW
Sbjct: 1324 EEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDA 1383
Query: 585 -EGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHI 643
+ + E K K A Q +E +AV ++ A ++ K L+ E+++L + +
Sbjct: 1384 IQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK-------TKQRLQNEVEDLMIDV 1436
Query: 644 SIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKS 703
AA C+A ++ ++N ++L + QK E + L++
Sbjct: 1437 ERSNAA------CIALDKK-----------------QRNFDKVLAEWKQKYEETQAELEA 1473
Query: 704 FEKRSRKLK--------------EGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKG 749
+K SR L + + L +EN L+ + E K + ++ K
Sbjct: 1474 SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKV 1533
Query: 750 SKDVEKENTELQVKISE----LETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRA 805
K ++ E +ELQ + E LE E + R E N +++E + I EK +
Sbjct: 1534 KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKI--AEKDEELDQLK 1591
Query: 806 KSEMATMKVRSGRYDCKTTMTKVKFKAAKK-NCSVGRHHTVLNHSIKVMSNVFENLS--- 861
++ + ++ D + + KK + LNH+ + + NL
Sbjct: 1592 RNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQ 1651
Query: 862 ---KD---GWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQ 915
KD +D D + Q + +VE + E + + + TE +
Sbjct: 1652 GILKDTQLHLDDAIRGQDDLKEQLA------MVERRANLMQAEVEELRASLERTE----R 1701
Query: 916 GKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKK----NCKMQKSSHTAVPTRVNREKYKN 971
G+++ + L +D H +N +KK ++Q V N E+
Sbjct: 1702 GRKMAEQEL-LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEE--- 1757
Query: 972 ITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQ 1031
A+K+ ++ ++ E + Q ++ L+ KK E +VK+ + L + +
Sbjct: 1758 -KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ------LRLDEAEQLALK 1810
Query: 1032 TSRQTIKKLNLDLAGLRKEKEDLLK-KLESSSEITSLAEENSQVTFPRIQVTSLSPSRSM 1090
++ I+KL + L E E K +E+ + ++T+ + + + R
Sbjct: 1811 GGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTY-QTEEDRKNILRLQ 1869
Query: 1091 DLEMK-QLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKR 1147
DL K Q + K E ++ SNV KF L E ++E E+ E + R
Sbjct: 1870 DLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHE--LEEAKERADIAESQVNKLR 1925
Score = 102 bits (255), Expect = 2e-21
Identities = 189/1077 (17%), Positives = 443/1077 (41%), Gaps = 128/1077 (11%)
Query: 380 YQKLYNELHICFETTKSNEAM--LRQSVTNLQDQLLQKEQENAKLKEKL----QESQGAP 433
+ KLY ++ ++ ++ + M +++ +++L + E + +L+EK+ QE
Sbjct: 833 WMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ 892
Query: 434 LPLPQESDPDYSAQ------VPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENIS 487
L + E+D A+ + + L + + + + E + +L KL + S
Sbjct: 893 LQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 952
Query: 488 A-NKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDS-----------------EELQ 529
K + + K K + ++L+ + + D + L
Sbjct: 953 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012
Query: 530 KLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGM 589
L+ E K+ L KA Q+ D+L + E+ K+ L+ R ++ LK +E +
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072
Query: 590 TEI------RKIKRADPQ----QLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDEL 639
TE K+K+ + + Q + ED A+ +L +++ +EL + LEEE++
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQL---QKKIKELQARIEELEEEIEAE 1129
Query: 640 KVHISIDKAAIQELNRC---VAERREEQLFRSGEDDEVKRSTP---EKNGKEMLEQTLQ- 692
+ + + +L+R ++ER EE + E+ + +K +++ E TLQ
Sbjct: 1130 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQH 1189
Query: 693 -------------KVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQ------- 732
V EL ++ S ++ +KL++ +L E + L S ++
Sbjct: 1190 EATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANF 1249
Query: 733 QEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENE--- 789
++ T E +L +I ++ ++ EL + + L TE RQ+ E +A+ ++
Sbjct: 1250 EKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGK 1309
Query: 790 ----ELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTV 845
+ I +++ + +AKS +A ++S R+DC + + + K + R +
Sbjct: 1310 QAFTQQIEELKRQLEEETKAKSTLAHA-LQSARHDCDLLREQYEEEQEAK-AELQRGMSK 1367
Query: 846 LNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKE 905
N + +E + E++ E+ AQ Q + + K + E K + +
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKL-AQRLQDAEEHVEAVNSKCASLEKTKQRLQ 1426
Query: 906 SDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVN 965
++ ED + + +D K +++ K +++ +++ S +
Sbjct: 1427 NE-VEDLMIDVERSNAACIALD-KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTE 1484
Query: 966 REKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQV 1025
K KN ++S ++ L+ +LQQ+ S L + E ++V ++L H++
Sbjct: 1485 LFKVKN-AYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSE 1543
Query: 1026 SDQRFQTSRQTI-----KKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQ 1080
+ + ++ K L + L L + K ++ +K+ E + N +Q
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLE-LNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQ 1602
Query: 1081 VT----------SLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIK 1130
T +L + M+ ++ +++ +L +A + + N++ + L + H+
Sbjct: 1603 STLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLD 1662
Query: 1131 E-------MHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTE 1183
+ + E+++ +ER + + +E+L+ + K + L + ++V+ L
Sbjct: 1663 DAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLL-- 1720
Query: 1184 ECSNKKVSIDSLKQRLNVAVKE-KSQYEQMYQKSKEELEKKDLKLT---LLVSRISETES 1239
+ S+ + K++L + + + + E + Q+++ EK +T ++ + + +
Sbjct: 1721 --HTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQD 1778
Query: 1240 AMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVR 1299
A +E Q + ++ E Q L +++++ V+ L E++++ +
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESE---QK 1835
Query: 1300 RQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDA 1356
+ +K ++K+ K T++ + D + IL +D V+ +TK+ A
Sbjct: 1836 HNVEAVKGLRKHERRVKELTYQTE-----------EDRKNILRLQDLVDKLQTKVKA 1881
Score = 102 bits (255), Expect = 2e-21
Identities = 193/962 (20%), Positives = 385/962 (40%), Gaps = 124/962 (12%)
Query: 492 FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENL---EKALQLK 548
F K ++ SAE + KE + K +E K ++ E K+ L + LQL+
Sbjct: 838 FKIKPLLKSAETE-KEMANMKEEFEKTKEELAKTEA--KRKELEEKMVTLMQEKNDLQLQ 894
Query: 549 SQ-ENDELRDAHEKRKERLQ---MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
Q E D L DA E+ + ++ L+ + V E+ + EE + +K K D
Sbjct: 895 VQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEE---LDELKVHISIDKAAIQELNRCVAERR 661
++D D + LA ++E + NL EE LDE ++ +K A+QE ++ +
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ E+D+V T K E L+ E E +L +R+++ EG+ KL +E
Sbjct: 1015 QM------EEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE 1068
Query: 722 NDFLKSLLKQQ-QEDTETREKELEQIIKGSKD-------VEKENTELQVKISELETEVTS 773
+ KQQ E + +E E+ + +D ++K+ ELQ +I ELE E+ +
Sbjct: 1069 STMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEA 1128
Query: 774 LRRQVAEANALRNE-NEELINPMEKSHQSADRAKSEMATMKVRSGRY-----DCKTTMTK 827
R A+A R++ + EL E+ ++ +++ K R + D + + +
Sbjct: 1129 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQ 1188
Query: 828 VKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWE---DVSESSSDSEAQTS---- 880
+ AA L I + V + L K+ E ++++ +S+ E +
Sbjct: 1189 HEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKAN 1248
Query: 881 -QTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKN 939
+ + + + +I E+ + + ++ + E + +D K +
Sbjct: 1249 FEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRG 1308
Query: 940 AKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQ 999
+ T Q + K Q T + + Q + + LLRE+ Q+ + LQ
Sbjct: 1309 KQAFTQQIEELKRQLEEETKAKSTLAH------ALQSARHDCDLLREQYEEEQEAKAELQ 1362
Query: 1000 NAKKTAELSVKEYK--------EVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEK 1051
A V +++ + E+L ++ QR Q + + ++ +N A L K K
Sbjct: 1363 RGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTK 1422
Query: 1052 EDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQ 1111
+ +L++ E + E S + R+ D + + + K + EL
Sbjct: 1423 Q----RLQNEVEDLMIDVERSNAACIALD----KKQRNFDKVLAEWKQKYEETQAELEAS 1474
Query: 1112 SSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEML 1171
++L EL + +E + + ++R+ NK
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRE---------------------NK------ 1507
Query: 1172 QNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLV 1231
NL +++ LTE+ + I L++ EKS+ + ++++ LE ++ K+ +
Sbjct: 1508 -NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQ 1566
Query: 1232 SRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKEL 1291
+++ +S + ++L +L +V+E Q TL + ++ ++ + K++
Sbjct: 1567 LELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTL---DAEIRSRNDALR-IKKKM 1622
Query: 1292 QNDV--------HVVRRQIRELKKMKKNRDACK-TSTHKAQTLAASILNISRSDLEEILD 1342
+ D+ H R+ L+ ++ + K T H + + DL+E L
Sbjct: 1623 EGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIR------GQDDLKEQLA 1676
Query: 1343 TED------QVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAV----LEKINEKK 1392
+ Q E+E+ + E + +K+ E +L AS ++ + IN KK
Sbjct: 1677 MVERRANLMQAEVEELRASLERTERG----RKMAEQELLDASERVQLLHTQNTSLINTKK 1732
Query: 1393 KL 1394
KL
Sbjct: 1733 KL 1734
Score = 95.1 bits (235), Expect = 4e-19
Identities = 209/1064 (19%), Positives = 417/1064 (39%), Gaps = 168/1064 (15%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
++ +A Q +++ SL++E LC D E KR + L Q ++ E +K
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCM-DLERA----KRKLEGDLKLAQESTMDTENDK 1077
Query: 153 QKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE 212
Q+ K +K + KI++ + L+++I +L R ++EE R + E
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 213 KKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQE---- 268
K+ D S+E+++ E ++ I E NKK + DLE+ Q
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQI----EMNKKREAEFQKMRRDLEESTLQHEATA 1193
Query: 269 AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVR 328
A LRK+ + A++ D+L ++++E +S+ L +++++ + +
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSE---LKMEINDLASNMETVSKAKANFE 1250
Query: 329 KELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELH 388
K + L++ + T +Q LI +L + +HT ES + + +E
Sbjct: 1251 KMCRTLEDQLSEIKTKEEEQQRLINELSA----------QKARLHT-ESGEFSRQLDEKD 1299
Query: 389 ICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQG--APLPLPQESDPDYSA 446
+ Q + L+ QL ++ + + L LQ ++ L E + + A
Sbjct: 1300 AMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359
Query: 447 QVPHRPSLSSLETLMVSQKSEIEYLQ--EKLKIANEKLSENISANKGFSRKSIMTSAEGK 504
++ S ++ E K E + +Q E+L+ A +KL++ + AE +
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ------------DAE-E 1406
Query: 505 HKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKE 564
H E + S L K +++++N + L + + ++ A +K++
Sbjct: 1407 HVEAVNSKCAS---------------LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQR 1451
Query: 565 RLQMLQTNYRAVKEQLK------QWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYF 618
+ ++ E+ + Q E S TE+ K+K A + L + L
Sbjct: 1452 NFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL---------DHLETL 1502
Query: 619 KRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRST 678
KREN+ NL++E+ +L I+ I EL + + E+ +E + S
Sbjct: 1503 KRENK-------NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL 1555
Query: 679 PEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTET 738
+ GK L+ EL N++KS E ++K+ ++++ L L + E+
Sbjct: 1556 EHEEGK-----ILRIQLEL-NQVKS---------EIDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 739 REKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKS 798
+ L+ I+ D + +++ ++E+E ++ RQ AEA + ++ +
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLH 1660
Query: 799 HQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFE 858
A R G+ D K + V+ +A V L + E
Sbjct: 1661 LDDAIR------------GQDDLKEQLAMVERRANLMQAEVEELRASLERT--------E 1700
Query: 859 NLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQG-- 916
K +++ ++S Q T T ++ T +K+ T+ SQ QG
Sbjct: 1701 RGRKMAEQELLDAS--ERVQLLHTQNTSLINTKKKLE-------------TDISQIQGEM 1745
Query: 917 KEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQK 976
++IVQ N + K K D +K + S+H + + K++ +
Sbjct: 1746 EDIVQEARNAEEKA-KKAITDAAMMAEELKK---EQDTSAHLERMKKNMEQTVKDLQLRL 1801
Query: 977 SSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKL-LHQQQVSDQRFQTSRQ 1035
+ + L+ +Q+ + ++ + E K E + L H+++V + +QT
Sbjct: 1802 DEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEED 1861
Query: 1036 TIKKLNLDLAGLRKEKEDLLKKLESSSEI----TSLAEENSQVTFPRIQVTSLSPSRSMD 1091
L L +DL+ KL++ + AEE S V +
Sbjct: 1862 RKNILRL---------QDLVDKLQTKVKAYKRQAEEAEEQSNVNLAK------------- 1899
Query: 1092 LEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEK 1135
++LQ++L+ A S V L+ + ++E H K + E+
Sbjct: 1900 --FRKLQHELEEAKERADIAESQVNKLRVK--SREVHTKVISEE 1939
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 137 bits (345), Expect = 7e-32
Identities = 243/1200 (20%), Positives = 509/1200 (42%), Gaps = 157/1200 (13%)
Query: 260 DLEKLRKQEAHLRKEKYSTDAK---IKTFEDNLIEARKEVEVSQSKYNALSLQLSN---K 313
DL+K+ L+K K + K + T + L +A++ + +Y L L K
Sbjct: 800 DLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEK 859
Query: 314 QTEL------IQKDMDITL--VRKELQELQNLYKQNST-------HTAQQAELIQQLQVL 358
T+L I K +D L + K++++L+N Y+ N ++ + ++ ++
Sbjct: 860 VTQLTDRWQRIDKQIDFRLWDLEKQIKQLRN-YRDNYQAFCKWLYDAKRRQDSLESMKFG 918
Query: 359 NMDT-QKVLRNQEDVHTAESISYQK---LYNELHICFETTKSNEAMLRQSVTNLQDQLLQ 414
+ +T + L Q+++H+ S K + +C + K E L + L+ L
Sbjct: 919 DSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLL-- 976
Query: 415 KEQENAKLKEKLQESQGAPLPLPQESDP------------DYSAQVPHRPSLSSLETLMV 462
N +K + +S + L + +D DY + L SLE L +
Sbjct: 977 ----NIPIKRTMIQSPSGVI-LQEAADVHARYIELLTRSGDYYRFLSEM--LKSLEDLKL 1029
Query: 463 SQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSF 522
+ ++IE L+E+L++A + SEN + NK + AE + + L ++
Sbjct: 1030 -KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL 1088
Query: 523 TDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQ 582
Q L K +I+ L + + + E ++ + + ++R + +Y +++ +
Sbjct: 1089 DGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQC 1148
Query: 583 WEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRE-NQELMIQKMNLEEELDELK- 640
+E G ++ K ++ E + E KRE EL + + EE+ L+
Sbjct: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRN 1208
Query: 641 ---VHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTEL 697
I+I K I+E++ + + + + R+ D + + K+ L ++ + TE
Sbjct: 1209 KYETEINITKTTIKEIS--MQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQ 1266
Query: 698 ENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQ-QQEDTETREKELEQIIKGSKDVEKE 756
R E+ + + K ++M++ L+ LKQ Q+ +E + + + + +K ++ +
Sbjct: 1267 RRRA---EENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDK 1323
Query: 757 NTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRS 816
N E++ +E + E E + +RN +E I ++ ++ ++E+ K
Sbjct: 1324 NKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLK------NQFETEINITKTTI 1377
Query: 817 GRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVF----ENLSKDGWEDVSESS 872
+ + ++A N + R + L+ IK + N ENL + + + +
Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLT--RENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA 1435
Query: 873 SDSE-AQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKT- 930
+ SE +Q Q L + + +Q + Q D + Q + KEI + ID +T
Sbjct: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETN 1495
Query: 931 PKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIIS 990
+ D+NA+ Q+ +QK++ +A T +N+ K + + + + +
Sbjct: 1496 DRKCLEDENAR---LQRVQYDLQKANSSATET-INKLKVQEQELTRLRIDYERVSQERTV 1551
Query: 991 LQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKE 1050
Q + QN+ K +L ++ +E +L ++ S+ + KKL +L G+R+
Sbjct: 1552 KDQDITRFQNSLKELQLQKQKVEEELNRL--KRTASEDSCKR-----KKLEEELEGMRRS 1604
Query: 1051 KEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKL-------KN 1103
+ E + +IT+L ++ ++ S+ RS D +++Q + L +
Sbjct: 1605 LK------EQAIKITNLTQQ--------LEQASIVKKRSED-DLRQQRDVLDGHLREKQR 1649
Query: 1104 ATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLES 1163
EL + SS V+ L+ +LL ++E +K+ H + ++ I K + + K+ +E
Sbjct: 1650 TQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE----SKIEIER 1705
Query: 1164 NKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKK 1223
+S +E NL K+ L EE N ++ D L++ + A +K+ + + +
Sbjct: 1706 LQSLTE---NLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNR 1762
Query: 1224 DLKLTLLVSRIS-ETESAMAEIE------TAASKQLQELALQSEQVLEGAQKTLLLANEK 1276
L+L L++ + E E+ EIE AS ++QE Q QV++ +++LL+ +
Sbjct: 1763 TLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-ERESLLVKIKV 1821
Query: 1277 VEEFTTFVKALAKEL------------------------QNDVH-----------VVRRQ 1301
+E+ ++ L EL QND++ +R+
Sbjct: 1822 LEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKI 1881
Query: 1302 IRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEE-ILDTEDQVEIEKTKIDAENDK 1360
E +K ++ +++ ++ + Q I R LE+ +T+ Q+E E+++ E DK
Sbjct: 1882 ESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDK 1941
Score = 92.8 bits (229), Expect = 2e-18
Identities = 219/1081 (20%), Positives = 442/1081 (40%), Gaps = 176/1081 (16%)
Query: 100 TRTQLLEEELSSLKEELAL-CQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK 158
T+ ++LEEEL ++ + C +K +L K + ++ SL E K+++E
Sbjct: 1032 TKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL--EELKRQAELD 1089
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
+ + L +I+E ++ + L EI D +R+ +V++ + ++ L+K + +
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
Query: 219 SQEI----KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLR---KQEAHL 271
+ + ++++ ++ KE + + L+EE TR + N+L K+R +E
Sbjct: 1150 KENLGWQKLESEKAIKEKEYEIERLRVLLQEE----GTRKREYENELAKVRNHYNEEMSN 1205
Query: 272 RKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
+ KY T+ I I +KE + S++ N L +LS + +L KD + L L
Sbjct: 1206 LRNKYETEINITKTTIKEISMQKE-DDSKNLRNQLD-RLSRENRDL--KDEIVRLNDSIL 1261
Query: 332 QELQNLYKQNSTHTAQQA---ELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELH 388
Q + + Q+A E++Q+ Q L ++ ++V++ + +
Sbjct: 1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSE----------------- 1304
Query: 389 ICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQV 448
+ A +QS+ + K +E +LK + QE + +Y ++
Sbjct: 1305 --------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQEE--------AKRRWEYENEL 1348
Query: 449 PHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEP 508
+ E + + + E E K I ++ + G+ + + E +
Sbjct: 1349 SKVRNNYDEEIISLKNQFETEINITKTTI-HQLTMQKEEDTSGYRAQIDNLTRENRSLSE 1407
Query: 509 PVKRSRSLSPKSSFTDSEELQKLRKAERKIENLE----KALQLKSQENDELRDAHEKRKE 564
+KR ++ T ++ + LR+ E I+ + + Q K Q ELR + R E
Sbjct: 1408 EIKRLKN-------TLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE 1460
Query: 565 R----LQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKR 620
Q L + ++++ K EI ++K+ ++ D + +E A +R
Sbjct: 1461 ESVRYKQSLDDAAKTIQDKNK---------EIERLKQLIDKE--TNDRKCLEDENARLQR 1509
Query: 621 ENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPE 680
+L + E +++LKV QEL R + R+ +D ++ R
Sbjct: 1510 VQYDLQKANSSATETINKLKVQ-------EQELTRLRIDYERVSQERTVKDQDITRF--- 1559
Query: 681 KNGKEMLEQTLQKVTELENRLKSF-------EKRSRKLKEGNKKLMKENDFLKSLLKQQQ 733
+N + L+ QKV E NRLK K+ + EG ++ +KE + L QQ
Sbjct: 1560 QNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQL 1619
Query: 734 EDTETREKELEQIIKGSKDV----EKENTELQVKISELETEVTSLRRQVAE----ANALR 785
E +K E ++ +DV +E Q ++ L +EV +LRRQ+ +
Sbjct: 1620 EQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAH 1679
Query: 786 NENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTV 845
NE +E +S + +K E+ ++ ++T+ ++ + H +
Sbjct: 1680 LRNEHFQKAIEDKSRSLNESKIEIERLQ----------SLTE----------NLTKEHLM 1719
Query: 846 LNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKE 905
L ++ + +++L + SE+ SD A TI+ SQ Q
Sbjct: 1720 LEEELRNLRLEYDDLRRGR----SEADSDKNA-------TILELRSQL---------QIS 1759
Query: 906 SDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVN 965
++ T + Q ++ + N+ + K +K + N ++Q+S + T+V
Sbjct: 1760 NNRTLELQGLINDLQRERENLRQEIEK-------FQKQALEASN-RIQESKNQC--TQVV 1809
Query: 966 REKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKT--AELSVKEYKEVNEKLLHQQ 1023
+E+ + I +L + LQ+ L AK T AE VK+ E EK Q
Sbjct: 1810 QERESLLV------KIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLEC-EKQQIQN 1862
Query: 1024 QVSDQRFQTSR--QTIKKLNLDLAGLRKEKEDLLKKLES-SSEITSL-------AEENSQ 1073
++ + Q SR + I+K+ + +EK L ++E +EI + E++++
Sbjct: 1863 DLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTR 1922
Query: 1074 VTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMH 1133
T +++ R +D +++Q Y T + + + L F+ L K+ +++
Sbjct: 1923 ETQSQLETERSRYQREID-KLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1981
Query: 1134 E 1134
E
Sbjct: 1982 E 1982
Score = 88.2 bits (217), Expect = 5e-17
Identities = 157/708 (22%), Positives = 297/708 (41%), Gaps = 95/708 (13%)
Query: 95 EEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWK----RLQVTNPDLTQVVSLVVER 150
+E +++ E E++ K + KE S ++ L N L++ + +
Sbjct: 1356 DEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNT 1415
Query: 151 EKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSD 210
Q +E R+V E +Q + A E QR+ L+ E+ + + + EE+ ++ D
Sbjct: 1416 LTQTTENL-RRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRT---EESVRYKQSLDD 1471
Query: 211 LEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAH 270
K +DK++EI+ K+ + +KE +R K LE+EN +L + DL+K
Sbjct: 1472 AAKTIQDKNKEIERLKQLI-DKETNDR---KCLEDENARLQR----VQYDLQKANSSATE 1523
Query: 271 LRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKE 330
T K+K E L R + E ++S ++T KD DIT +
Sbjct: 1524 -------TINKLKVQEQELTRLRIDYE-----------RVSQERTV---KDQDITRFQNS 1562
Query: 331 LQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVH------TAESISYQKLY 384
L+ELQ L KQ + EL + + + D+ K + +E++ ++I L
Sbjct: 1563 LKELQ-LQKQKV-----EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLT 1616
Query: 385 NELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDY 444
+L K +E LRQ L L +K++ +L+ E + L QE +
Sbjct: 1617 QQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVK 1676
Query: 445 SAQVPHRPSLSSLETLMVS---QKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSA 501
A + + ++E S K EIE LQ L+EN++ ++ +M
Sbjct: 1677 QAHLRNEHFQKAIEDKSRSLNESKIEIERLQS--------LTENLT------KEHLMLEE 1722
Query: 502 EGKH---KEPPVKRSRSLSPKSSFTDSEELQ-KLRKAERKIENLEKALQLKSQENDELRD 557
E ++ + ++R RS + EL+ +L+ + + L+ + +E + LR
Sbjct: 1723 ELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQ 1782
Query: 558 AHEKRKERLQMLQTNYRAVKEQLKQ--WEEGSGMTEIRKIKRADPQQLRQEDS-DAVWNE 614
EK +++ + K Q Q E S + +I+ +++ + R ED + +
Sbjct: 1783 EIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKST 1842
Query: 615 LAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELN--RCVAERREEQLFRSGE-- 670
L R Q L +K ++ +L++ K S + AI+++ R +ER + L E
Sbjct: 1843 LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL 1902
Query: 671 DDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKE----------------- 713
E+KR E+ +++ + T + ++LE +++ KL++
Sbjct: 1903 QAEIKR-IEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTV 1961
Query: 714 GNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQ 761
KL+ + K Q E + L++++KG K VE+ +E+Q
Sbjct: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ 2009
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 136 bits (342), Expect = 2e-31
Identities = 254/1212 (20%), Positives = 492/1212 (40%), Gaps = 189/1212 (15%)
Query: 107 EELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQ-----VVSLVVEREKQKSEAKDRK 161
EE++ LKEE A Q E + L+ LTQ ++ L E+E + + +
Sbjct: 859 EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCE 918
Query: 162 VLEILQVK-DAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQ 220
L +++ +A+++E +R ++ ++L R +++E L+KE DLE +
Sbjct: 919 WLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEK 978
Query: 221 EIKDTKECVQNKEEQ---------------------NRLVIKNLEEENKKLST------R 253
E + T+ V+N E+ ++ + +L E +KLS+ +
Sbjct: 979 EKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLK 1038
Query: 254 CTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNK 313
+++LE +QE RK + + + ++ E NL R+ +E +S L+ +L K
Sbjct: 1039 LEQQVDELEGALEQE---RKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Query: 314 QTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVH 373
+ EL Q + + + + +LQ K+ T Q +L ++L+ K+ R + D+
Sbjct: 1096 ELELSQMNSKVENEKGLVAQLQKTVKELQT---QIKDLKEKLEAERTTRAKMERERADL- 1151
Query: 374 TAESISYQKLYNELH----ICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEK---- 425
T + + E+ E TK E ++ ++++ L E +A LK++
Sbjct: 1152 TQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADS 1211
Query: 426 LQESQGAPLPLPQ---ESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYL----QEKLKIA 478
L E +G L Q + + D S L + M K+ E L +E+L A
Sbjct: 1212 LAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEA 1271
Query: 479 NEKLSENIS-ANKGFSRKSIMTSAEGKH----KEPPVKRSRSLSPKSSFTDS-EELQ-KL 531
KL + AN ++K+ + S G+ +E ++ KS+FT E+L+ +L
Sbjct: 1272 TAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQL 1331
Query: 532 RKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTE 591
K + L ALQ ++ D LR+ +E+ +E L V ++ QW
Sbjct: 1332 EKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQW-------- 1383
Query: 592 IRKIKRADPQQLRQEDSDAVWNELAYFKRENQELM----IQKMNLEEELDELKVHISIDK 647
++K + R ED + ELA +E E M + +LE +L++ +
Sbjct: 1384 --RMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELG--- 1438
Query: 648 AAIQELN--RCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFE 705
A+ +L R A R +++ +SG+ + E++ + +L+ + ++V L L +
Sbjct: 1439 DALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEES-QALLDASQKEVQALSTELLKLK 1497
Query: 706 KRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKIS 765
+ G + L +EN L+ + K L ++ K K +E+E TE+QV +
Sbjct: 1498 NTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLE 1557
Query: 766 ELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTM 825
E E + RNE++ L +E AK+E+
Sbjct: 1558 ETEGALE------------RNESKILHFQLELLE-----AKAELERKLSEKDE------- 1593
Query: 826 TKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGT 885
+++ K+ C++ D +SS DSEA++ +
Sbjct: 1594 -EIENFRRKQQCTI---------------------------DSLQSSLDSEAKSRIEVTR 1625
Query: 886 IIVETSQKISPTEDGKDQKESDPTEDSQTQGK---EIVQTYLNIDGKTPKDYFHDKNAKK 942
+ + + ++ E +E +++ G+ +I + +D T + D +
Sbjct: 1626 LKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLN--SDLKEQV 1683
Query: 943 PTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAK 1002
+++N +Q + E+ + + S ++ ERI QN+ L + K
Sbjct: 1684 AVAERRNSLLQSELEDLRSLQEQTERGRRL----SEEELLEATERINLFYTQNTSLLSQK 1739
Query: 1003 KTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSS 1062
K E V ++ E+++ Q Q + + KK ++ A L +E LKK + +
Sbjct: 1740 KKLEADVARMQKEAEEVV-------QECQNAEEKAKKAAIEAANLSEE----LKKKQDTI 1788
Query: 1063 EITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFEL 1122
EN + T +Q R + E Q L + ++ K S V+ L+ EL
Sbjct: 1789 AHLERTRENMEQTITDLQ------KRLAEAE----QMALMGSRKQIQKLESRVRELEGEL 1838
Query: 1123 LAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLT 1182
+ E R+ER I++L ++ + E K+ S M +DK
Sbjct: 1839 EGEIRRSAEAQRGARRLER-------CIKELTYQAE---EDKKNLSRMQTQMDKL----- 1883
Query: 1183 EECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMA 1242
++ + + KQ++ VA + +QY Y+K + EL + + + S++++ +
Sbjct: 1884 ------QLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAR 1937
Query: 1243 EIETAASKQLQE 1254
E K++QE
Sbjct: 1938 EF----GKKVQE 1945
Score = 107 bits (266), Expect = 1e-22
Identities = 218/1072 (20%), Positives = 448/1072 (41%), Gaps = 157/1072 (14%)
Query: 395 KSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSL 454
KS+E + + V L+++ Q ++ K + + +E + + L QE + + +L
Sbjct: 853 KSSE--VGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETL 910
Query: 455 SSLETLMVSQ-KSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRS 513
+++E KS+I+ L+ ++K +E++ E N S +T+ K ++ +
Sbjct: 911 ANVEEQCEWLIKSKIQ-LEARVKELSERVEEEEEIN------SELTARGRKLEDECFELK 963
Query: 514 RSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDEL-------RDAHEKRKERL 566
+ + + E +K R E K++NL + ++ +++ +L ++AH++ + L
Sbjct: 964 KEIDDLETMLVKSEKEK-RTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL 1022
Query: 567 QMLQTNYRAV-KEQLK---QWEEGSGMTEI-RKIKRADPQQLRQEDSDAVWNELAYFKRE 621
M + ++ K LK Q +E G E RK + ++L + + + N + E
Sbjct: 1023 HMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLE 1082
Query: 622 NQE--LMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTP 679
+ + L + E EL ++ + +K + +L + V E + Q+ E E +R+T
Sbjct: 1083 SSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKEL-QTQIKDLKEKLEAERTTR 1141
Query: 680 EKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLK------------- 726
K +E + T Q + +L RL+ S E KK +E F K
Sbjct: 1142 AKMERERADLT-QDLADLNERLEEVGGSSLAQLEITKK--QETKFQKLHRDMEEATLHFE 1198
Query: 727 ----SLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEAN 782
SL K+ + E ++E + + + +EK+ ++LQ+++ +L T V + R A A
Sbjct: 1199 TTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAE 1258
Query: 783 ALRNENEELINPMEKSHQSADRAKSEMATMKVR----SGRYDCKTTMTKVKFKAAKKNCS 838
L EE ++ + +++A K + SG + + +++ K A N
Sbjct: 1259 KLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEF-----LRRLEEKEALIN-Q 1312
Query: 839 VGRHHTVLNHSIKVMSNVFENLSK----------------DGWEDVSESSSDSEAQTSQT 882
+ R + I+ + E +K D + E + +A+ +T
Sbjct: 1313 LSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRT 1372
Query: 883 LGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKK 942
L + E Q E+ Q+ TED + KE L I + + NA+
Sbjct: 1373 LSKVNAEMVQWRMKYENNVIQR----TEDLEDAKKE-----LAIRLQEAAEAMGVANARN 1423
Query: 943 PTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAK 1002
+ ++ ++Q A+ S++ +R L Q+ LQ+ K
Sbjct: 1424 ASLERARHQLQLELGDAL------------------SDLGKVRSAAARLDQKQ--LQSGK 1463
Query: 1003 KTAELSVKEYKEVNEKLLHQQQVSDQRFQTS----RQTIKKLNLDLAGLRKEKEDLLKKL 1058
A+ K+ E ++ LL Q Q T + T ++ + LR+E ++L +++
Sbjct: 1464 ALADW--KQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEI 1521
Query: 1059 ESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTL 1118
S +T+ E ++ +V L ++ E ++Q L+ L + S +
Sbjct: 1522 ---SNLTNQVREGTKNLTEMEKVKKL-----IEEEKTEVQVTLEETEGALERNESKILHF 1573
Query: 1119 KFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKV 1178
+ ELL E + +ER ++ K IE+ + +Q+ ++S +S +LD +
Sbjct: 1574 QLELL----------EAKAELERKLSEKDEEIENFRRKQQCTIDSLQS------SLDSEA 1617
Query: 1179 KTLTEECS-NKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKL-----TLLVS 1232
K+ E KK+ D + L ++ + E + +++ KDL++ T L S
Sbjct: 1618 KSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS 1677
Query: 1233 RISETESAMAEIETAASKQLQELALQSEQVLEG---AQKTLLLANEKVEEF---TTFVKA 1286
+ E + + +L++L EQ G +++ LL A E++ F T + +
Sbjct: 1678 DLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLS 1737
Query: 1287 LAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQ 1346
K+L+ DV ++++ E+ + C+ + KA+ A N+S EE+ +D
Sbjct: 1738 QKKKLEADVARMQKEAEEVVQ------ECQNAEEKAKKAAIEAANLS----EELKKKQDT 1787
Query: 1347 V-EIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKLVEG 1397
+ +E+T+ EN ++ + +QK L A ++K+ + + +EG
Sbjct: 1788 IAHLERTR---ENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEG 1836
Score = 106 bits (265), Expect = 1e-22
Identities = 250/1224 (20%), Positives = 508/1224 (41%), Gaps = 217/1224 (17%)
Query: 186 EINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTK-ECVQNKEEQNRLVIKNLE 244
+I LVK V EE A L++E + L+K + + ++ K + V +E+N L+++ L+
Sbjct: 847 KIKPLVKSS-EVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQ-LQ 904
Query: 245 EENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYN 304
E + L+ + +Q L K K +A++K L E +E E S+
Sbjct: 905 AEQETLAN-----------VEEQCEWLIKSKIQLEARVK----ELSERVEEEEEINSELT 949
Query: 305 ALSLQLSNKQTELIQK--DMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDT 362
A +L ++ EL ++ D++ LV+ E K+ T + L ++++ LN D
Sbjct: 950 ARGRKLEDECFELKKEIDDLETMLVKSE--------KEKRTTEHKVKNLTEEVEFLNEDI 1001
Query: 363 QKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKL 422
K+ R + V A +Q+ ++LH+ +++L + N KL
Sbjct: 1002 SKLNRAAKVVQEA----HQQTLDDLHM------------------EEEKLSSLSKANLKL 1039
Query: 423 KEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKL 482
++++ E +GA L QE + + E+ L+ LK+ E +
Sbjct: 1040 EQQVDELEGA---LEQERKARMNCE------------------RELHKLEGNLKLNRESM 1078
Query: 483 SENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEE--LQKLRKAERKIEN 540
EN+ +++ + + K+ LS +S ++E+ + +L+K ++++
Sbjct: 1079 -ENLESSQRHLAEELR------------KKELELSQMNSKVENEKGLVAQLQKTVKELQT 1125
Query: 541 LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGS-GMTEIRKIKRAD 599
K L+ K + R E+ ER + Q + + E+L++ S EI K +
Sbjct: 1126 QIKDLKEKLEAERTTRAKMER--ERADLTQ-DLADLNERLEEVGGSSLAQLEITKKQETK 1182
Query: 600 PQQLRQEDSDAVWN---ELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQ-ELNR 655
Q+L ++ +A + A K+ + + + + E L ++K + DK+ +Q E++
Sbjct: 1183 FQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDD 1242
Query: 656 CVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGN 715
+ R EQ+ R+ + E + E+ E + L KVT+L N L + + KL +
Sbjct: 1243 LLT--RVEQMTRAKANAEKLCTLYEERLHEATAK-LDKVTQLANDLAA---QKTKLWSES 1296
Query: 716 KKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLR 775
+ ++ + ++L+ Q + +++E + +EKE T+ Q ++ +L+
Sbjct: 1297 GEFLRRLEEKEALINQLSREKSNFTRQIEDL---RGQLEKE-TKSQSALAH------ALQ 1346
Query: 776 RQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKK 835
+ + + LR + EE + H++ + +EM +++ Y+ + AKK
Sbjct: 1347 KAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMK---YENNVIQRTEDLEDAKK 1403
Query: 836 NCSVGRHHTV--------LNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTL--GT 885
++ N S++ + + D D+ + S + + L G
Sbjct: 1404 ELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGK 1463
Query: 886 IIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTF 945
+ + QK +ES D+ + + + T L K+ + + + T
Sbjct: 1464 ALADWKQK---------HEESQALLDASQKEVQALSTEL----LKLKNTYEESIVGQETL 1510
Query: 946 QKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNII---------LLRERIISLQQQNS 996
+++N +Q+ T RE KN+T + +I L E +L++ S
Sbjct: 1511 RRENKNLQEEISNL--TNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNES 1568
Query: 997 V-------LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRK 1049
L AK E + E E E +QQ + Q+S + K +++ L+K
Sbjct: 1569 KILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKK 1628
Query: 1050 EKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRS-MDLEMKQLQYKLKNAT--N 1106
+ E+ L ++E Q++ QV+ + S + +++K LQ +L ++T N
Sbjct: 1629 KMEEDLNEMEL------------QLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLN 1676
Query: 1107 ELTKQSSNVKTLKFELLAKE-EHIKEMHEKISRMERDITMKRHLIE-----DLKFRQKVN 1160
K+ V + LL E E ++ + E+ R R + L+E +L + Q +
Sbjct: 1677 SDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRR--LSEEELLEATERINLFYTQNTS 1734
Query: 1161 LESNKSFSEM-LQNLDKKVKTLTEECSN-----KKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
L S K E + + K+ + + +EC N KK +I++ L+ +K+K +
Sbjct: 1735 LLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAAN--LSEELKKKQDTIAHLE 1792
Query: 1215 KSKEELEKK--DLKLTL-----------------LVSRISETESAM-AEIETAASKQ--- 1251
+++E +E+ DL+ L L SR+ E E + EI +A Q
Sbjct: 1793 RTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGA 1852
Query: 1252 ------LQELALQSEQV---LEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQI 1302
++EL Q+E+ L Q + KV+ + V+ + + ++Q
Sbjct: 1853 RRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQ 1912
Query: 1303 RELKKMKKNRDACKTSTHKAQTLA 1326
EL ++K+ + ++ +K + A
Sbjct: 1913 HELNEVKERAEVAESQVNKLKIKA 1936
Score = 51.6 bits (122), Expect = 5e-06
Identities = 64/238 (26%), Positives = 107/238 (44%), Gaps = 25/238 (10%)
Query: 93 SVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREK 152
S++E +L EEEL E + L + S K+L+ + + VV+ E
Sbjct: 1702 SLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQ-EC 1760
Query: 153 QKSEAKDRK-------VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFL- 204
Q +E K +K + E L+ K I E+ ++Q I DL KR +A E+ A +
Sbjct: 1761 QNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKR-LAEAEQMALMG 1819
Query: 205 -RKEFSDLEKKFKDKSQEIK-DTKECVQNKEEQNRL--VIKNL----EEENKKLSTRCTD 256
RK+ LE + ++ E++ + + + + RL IK L EE+ K LS T
Sbjct: 1820 SRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQ 1879
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDA-----KIKTFEDNLIEARKEVEVSQSKYNALSLQ 309
+ D +L+ Q + E T A K K + L E ++ EV++S+ N L ++
Sbjct: 1880 M--DKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIK 1935
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 136 bits (342), Expect = 2e-31
Identities = 292/1360 (21%), Positives = 570/1360 (41%), Gaps = 236/1360 (17%)
Query: 139 DLTQVVSLVVEREKQKSEAKDR---KVLEILQVKDAKIQEFEQRESVLKQEI---NDLV- 191
+LT+ V + + K+ EA +LE+ Q KD +E ++ L++E+ NDL+
Sbjct: 302 ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS 361
Query: 192 --KRKIAV--DEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEEN 247
KRK A+ +EE A + + + K K +K T+ E Q++L+++ LE N
Sbjct: 362 ATKRKGAILSEEELAAMSPTAAAVAKIVKPG---MKLTELYNAYVETQDQLLLEKLE--N 416
Query: 248 KKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQS---KYN 304
K+++ +++ ++E R+E + + L +A KE++ Q K N
Sbjct: 417 KRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
Query: 305 ALS--LQLSNKQTELIQKDMD--ITLVRKELQELQNLY-----KQNSTHTAQQAELIQQ- 354
S L+ N++ E+ KD+ I ++ EL+E + + + +S + +E+I Q
Sbjct: 477 KQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH 536
Query: 355 ------LQVLNMDTQKVL---------RNQEDVHTAESISYQKLYNELHICFETTKSNEA 399
++ L Q++L R +E+ T S EL + E+ +
Sbjct: 537 LVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS-----KITELQLKLESALTELE 591
Query: 400 MLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYS-AQVPHRPSLSSL- 457
LR+S + + ++ + L ++ G +PL S D S A P RPS S
Sbjct: 592 QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTV 651
Query: 458 ----------ETLMVSQKSEIEYLQE------KLKIANEKL----------------SEN 485
T + K+ ++ LQE K K NEK+ S+N
Sbjct: 652 STPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQN 711
Query: 486 --ISANKGFSRKS---IMTSAEGKHKEPPVKRSRSLSPKSSFTDSEEL------------ 528
IS F+ K + + EG +E R+ ++ E++
Sbjct: 712 TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGAN 771
Query: 529 QKLRKAERKIENLEKA---LQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEE 585
+KL AE + ENL+K L+L + R++ + +L TN + ++ L++ E
Sbjct: 772 EKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE- 830
Query: 586 GSGMTEIRKIKRADPQQLRQEDSDA---VWNELAYFKRENQELMIQKMNLEEELD-ELKV 641
TE ++ + ++L E S + NE+ + L +Q ++ + +LD E +
Sbjct: 831 ----TETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNL 886
Query: 642 HISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGK-------------EMLE 688
H++ K ++ + +A ++ S + +V + ++ GK L
Sbjct: 887 HLNT-KELLKNAQKEIATLKQHL---SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLR 942
Query: 689 QTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELE---- 744
QT ++V +L+ RLK+ + + L + + K + ++ +++ E R KE
Sbjct: 943 QTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQT 1002
Query: 745 QIIKGSKDVEKENTELQ-----------VKISELETEVTSLRRQVAEA-----NALRNEN 788
Q+ K +VEKE ELQ ++SEL+ ++S++ +V EA AL NE
Sbjct: 1003 QLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQ 1062
Query: 789 E-------------ELINPMEK----------SHQSADRAKSEMA---------TMKVRS 816
+ E N E+ + Q+A S+MA T K S
Sbjct: 1063 QARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122
Query: 817 GRYDCKTTMTK----VKFKAAKKNC---SVGRHHTVLNHSIKVMSNVFENLSKDGWEDVS 869
+CK + + +K + +K C + + + +L+ I+ +S+ K+G +
Sbjct: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPL 1182
Query: 870 ESSSDSEAQTSQTLGTII--VETSQKISPTEDGKDQKES-DPTEDSQTQGKEIVQTYLNI 926
S E ++ + + I+ + ++I+ T Q ES + + +E+ + ++
Sbjct: 1183 NVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSL 1242
Query: 927 DGKTPKDYFHDKN-AKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQ------KSSS 979
+ + K K A+ KK M T R +E+ + Q K
Sbjct: 1243 NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL 1302
Query: 980 NIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQ----------VSDQR 1029
+I+ L+E L +++ +LQ KK E VK +K N+ L+ QQ+ +S++
Sbjct: 1303 DILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKE 1362
Query: 1030 FQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSE-ITSLAEENSQVTFPRIQVTSLSPSR 1088
T R I++L ++ L+ E L ++ I SL E+ ++V + + +
Sbjct: 1363 VHTKR--IQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETI-----QK 1415
Query: 1089 SMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRH 1148
+D ++ +Q K+K T ++ K KT EL A+++ + E + S ++ +
Sbjct: 1416 DLDAKIIDIQEKVKTIT-QVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ 1474
Query: 1149 LIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSN---KKVSIDSLKQRLNVAVKE 1205
+++LK +KS ++NL K + E N + V + S RL +++
Sbjct: 1475 EMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD 1534
Query: 1206 K-SQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLE 1264
+ +Q EQ+ Q+ E+ EK + S+I+ +A ++ +K+ +EL ++
Sbjct: 1535 RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAH----LAGVKDQLTKENEELKQRN----- 1585
Query: 1265 GAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRE 1304
GA +++ +E + AL + + + + R++RE
Sbjct: 1586 GA------LDQQKDELDVRITALKSQYEGRISRLERELRE 1619
Score = 128 bits (321), Expect = 4e-29
Identities = 276/1346 (20%), Positives = 551/1346 (40%), Gaps = 177/1346 (13%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
R ++ + + KEEL +A+K + +RL LT+ V + E+ K+ + K
Sbjct: 105 RNIAIQSQFTRTKEEL---EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGE 161
Query: 161 KVLEI--LQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
L++ LQ D ++ E+R L+QE L + ++ E L+ + +L ++K
Sbjct: 162 LQLKLDELQASDVSVKYREKR---LEQEKELLHSQNTWLNTE---LKTKTDELLALGREK 215
Query: 219 SQEIKDTKECVQNKEEQ-NRLV--IKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEK 275
EI + K ++NK+E+ +RL + L+ N+ L DLL L++ ++Q+A + +EK
Sbjct: 216 GNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASM-EEK 274
Query: 276 YSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ 335
+ + NL + + S++K N +L+ EL + + K +Q+
Sbjct: 275 FHNELNAHIKLSNLY--KSAADDSEAKSN----ELTRAVEELHKLLKEAGEANKAIQD-- 326
Query: 336 NLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTK 395
+L + + + E+++++ L +K L N D+ +A L E T
Sbjct: 327 HLLEVEQSKDQMEKEMLEKIGRL----EKELENANDLLSATKRKGAILSEEELAAMSPTA 382
Query: 396 SNEAM----------LRQSVTNLQDQLLQKEQENAKLKEKLQE---SQGAPLPLPQESDP 442
+ A L + QDQLL ++ EN ++ + L E A P+ +
Sbjct: 383 AAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQRE 442
Query: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLS--ENISANKGFSRKSI--- 497
+Y + +++SL + EI+ LQE AN++ S E + K +
Sbjct: 443 EYERA---QKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQ 499
Query: 498 -------MTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQ 550
+ A G H V R +S + SE + + + R IE L++ Q
Sbjct: 500 IRVLLMELEEARGNH----VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLV 555
Query: 551 ENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDA 610
EL + E+ ++ T+ + + QLK S +TE+ +++++ Q++ DS
Sbjct: 556 ALRELGETREREEQE----TTSSKITELQLKL---ESALTELEQLRKSRQHQMQLVDS-- 606
Query: 611 VWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGE 670
++++ ++ L ++I L S
Sbjct: 607 ---------------IVRQRDMYRILLSQTTGVAI------------------PLHASSL 633
Query: 671 DDEVKRSTPEKNGKEMLEQTLQKVTELEN----RLKSFEKRSRKLKEGNKKLMKENDFLK 726
DD STP++ T V +E+ K+ K+ +++ E KK EN+ ++
Sbjct: 634 DDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQ 693
Query: 727 S--LLKQQQEDTETREKELEQIIKGSKDVEKENTE-LQVKISELETEVTSLRRQVAEANA 783
+ L K Q++ T+ R + + I D + E LQ + E+TSL + + A
Sbjct: 694 NEQLEKLQEQVTDLRSQNTK--ISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTA 751
Query: 784 LRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTK---VKFKAAKKN-CSV 839
+ E++IN M Q A ++A +VR+ + M K V+ +++ +
Sbjct: 752 TTQKQEQIINTMT---QDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAE 808
Query: 840 GRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTED 899
R +L +++ + + E SE +T Q L + I + +IS +
Sbjct: 809 QRGQNLLLTNLQTIQGILER---------------SETETKQRLSSQIEKLEHEISHLKK 853
Query: 900 GKDQKESDPTEDSQTQGKEIVQTYLNIDGKT-----PKDYFHDKNAKKPTFQKKNCKM-- 952
+ + ++ +++ T +D +T K+ + + T ++ M
Sbjct: 854 KLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEV 913
Query: 953 ----QKSSHTAVPTRVNREKYKNITAQ--KSSSNIILLRERIISLQQQNSVLQNAKKTAE 1006
Q S T N+E ++ +Q ++ + L+ER+ + Q + E
Sbjct: 914 QVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLE 973
Query: 1007 LSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDL----LKKLESSS 1062
S+ + K+V E++ +V R + S + +L L + KEK++L + +ES
Sbjct: 974 ESLNKEKQVTEEVRKNIEV---RLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESME 1030
Query: 1063 EITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFEL 1122
+ S ++ +Q S ++ E + + + A + Q+ + L
Sbjct: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLH- 1089
Query: 1123 LAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLT 1182
A E ++ E++S+M ++++HL E + + LE S+ E + L +V
Sbjct: 1090 AADVEALQAAKEQVSKM---ASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146
Query: 1183 EECSNKKV-------SIDSLKQRLNVAVKEKSQYEQMYQKSKE-ELEKKDLKLTLLVSR- 1233
C + + I+ L ++ +VKE Q S+E + +++ L++ + R
Sbjct: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE 1206
Query: 1234 --ISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKEL 1291
I+ET +A++E+ +Q EL E+ L+ Q +L EKV + T A +EL
Sbjct: 1207 KEIAETRFEVAQVESLRYRQRVELL---ERELQELQDSLNAEREKV-QVTAKTMAQHEEL 1262
Query: 1292 QNDVHVVRRQIRELKKMKKNRDACKTSTH----KAQTLAASILNISRSDLEEILDTEDQV 1347
+ + K +++ ++ + K + L IL + ++ E+ + +
Sbjct: 1263 MKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEAN-AELSEKSGML 1321
Query: 1348 EIEKTKIDAENDKEWMLYIQKLLEGQ 1373
+ EK K+ E+ K W Q L+ Q
Sbjct: 1322 QAEK-KLLEEDVKRWKARNQHLVSQQ 1346
Score = 114 bits (285), Expect = 7e-25
Identities = 235/1204 (19%), Positives = 468/1204 (38%), Gaps = 172/1204 (14%)
Query: 199 EENAFLRKEFSDLEKKFKDKSQEIKDTK---ECVQNKEEQNRLVIKNLEEENKKLSTRCT 255
E N + + LEK D+ EI K E + + EQ I+ K+LS
Sbjct: 13 ELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIE------KRLSHSQE 66
Query: 256 DLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQT 315
L+N+ + Q L EK + K T E KE+E++Q + A+ Q + +
Sbjct: 67 RLVNETREC--QSLRLELEKLNNQLKALT------EKNKELEIAQDRNIAIQSQFTRTKE 118
Query: 316 ELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTA 375
EL + D+ + L Q+L+ L D +++ ++ +T
Sbjct: 119 ELEAEKRDLIRTNERLS--------------------QELEYLTEDVKRLNEKLKESNTT 158
Query: 376 ESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLP 435
+ KL +EL + K E L Q L Q N L +L+ L
Sbjct: 159 KGELQLKL-DELQASDVSVKYREKRLEQEKELLHSQ-------NTWLNTELKTKTDELLA 210
Query: 436 LPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEK---LKIANEKLSENIS--ANK 490
L +E + + L+ + ++K E+ L+E+ LK +NE L +++ K
Sbjct: 211 LGREKGNE----------ILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK 260
Query: 491 GFSRKSIMTSAEGK-HKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKS 549
K S E K H E S KS+ DSE K + R +E L K L+
Sbjct: 261 LKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEA--KSNELTRAVEELHKLLKEAG 318
Query: 550 QENDELRD-AHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDS 608
+ N ++D E + + QM + + K+ E + + K K A L +E+
Sbjct: 319 EANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAI---LSEEEL 375
Query: 609 DAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRS 668
A+ A + ++ M L E + A ++ ++ + E+ E +
Sbjct: 376 AAMSPTAAAVAK----IVKPGMKLTE----------LYNAYVETQDQLLLEKLENKRINK 421
Query: 669 GEDDEVKRSTPE----KNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDF 724
D+ VK + K +E E+ + V L +L+ K ++L+E K K++
Sbjct: 422 YLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQS-- 479
Query: 725 LKSLLKQQQEDTETREKELEQIIK----------GS---KDVEKENTELQVKISELETEV 771
S+L++ E + K+L Q I+ G+ +D E + ++ + +
Sbjct: 480 --SVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
Query: 772 TSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFK 831
S R L+ +N+ L+ + + ++ +R + E + K+ + ++ +T+++
Sbjct: 538 VSYRN----IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQL 593
Query: 832 AAKKNC------SVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGT 885
+ S+ R + + + V L +DVS +S+ TSQT+ T
Sbjct: 594 RKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVST 653
Query: 886 I----IVETSQKISPTEDGKDQKE------SDPTEDSQTQGKEIVQTYLNIDGKTPKDYF 935
++E+++ I K +E + E+ + Q +++ + + ++
Sbjct: 654 PAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQN-- 711
Query: 936 HDKNAKKPTFQKKNCKMQKSSHTAVPTRVN--REKYKNITAQKSSSNIIL---------L 984
K + + F K +M + + + E+ + +TA I+
Sbjct: 712 -TKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGA 770
Query: 985 RERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIK------ 1038
E++ + + L+ K+ +LS + E LL +Q+ T+ QTI+
Sbjct: 771 NEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQR-GQNLLLTNLQTIQGILERS 829
Query: 1039 ------KLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDL 1092
+L+ + L E L KKLE+ E N V + L ++ L
Sbjct: 830 ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK-RQLDTETNLHL 888
Query: 1093 EMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIK-----EMHEKISRMERDITMKR 1147
K+L LKNA E+ ++ ++ ++ ++ E + + +
Sbjct: 889 NTKEL---LKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 1148 HLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKS 1207
+ DLK R K + + + + M+ +L+ E + +K + +++ + V +KE +
Sbjct: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLE-------ESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 1208 QYEQMYQKSKEELEKKDLKLTLLVSR-ISETESAMAEIE---TAASKQLQELALQSEQVL 1263
+++ +K E+EK+ +L R I E ++E++ ++ ++QE ++ L
Sbjct: 999 EFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTAL 1058
Query: 1264 EGAQKTLLLANEKVEEFTTFVKALAKELQ---NDVHVVRRQIRELKKMKKNRDACKTSTH 1320
Q+ E+ + +EL DV ++ ++ KM R + +T
Sbjct: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQ 1118
Query: 1321 KAQT 1324
KA++
Sbjct: 1119 KAES 1122
Score = 104 bits (260), Expect = 5e-22
Identities = 204/1022 (19%), Positives = 435/1022 (42%), Gaps = 146/1022 (14%)
Query: 101 RTQLLEEELSSLKEEL-ALCQADKEFVWSLWKRLQVTNPDLTQVV-----SLVVEREKQK 154
R ++L++ + + E+ +L + +++ + K+ Q+ N +TQ + L V + +
Sbjct: 724 RYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT-MTQDLRGANEKLAVAEVRAE 782
Query: 155 SEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSD---L 211
+ K++++L++ +V+ + +QRES+L ++ + + R E L
Sbjct: 783 NLKKEKEMLKLSEVRLS-----QQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRL 837
Query: 212 EKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLE----EENKKLSTRCTDLLNDLEKLRKQ 267
+ + EI K+ ++N+ EQ + +NL+ + ++L T LN E L+
Sbjct: 838 SSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNA 897
Query: 268 EAHLRKEKYSTDAKIKTFEDNLIEARKEVEV-SQSKYNALSLQLSNKQTELIQKDMD--I 324
+ + A +K N+ EV+V SQS Q SNK+ D+D +
Sbjct: 898 QKEI--------ATLKQHLSNM-----EVQVASQSSQRTGKGQPSNKE------DVDDLV 938
Query: 325 TLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLY 384
+ +R+ +++ +L ++ T T+ ++Q Q + + ES++ +K
Sbjct: 939 SQLRQTEEQVNDLKERLKTSTSN----VEQYQAMVTSLE------------ESLNKEKQV 982
Query: 385 NELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDY 444
E E K+ E L++S Q QL +K E K K++LQ+ + + ++ +
Sbjct: 983 TE-----EVRKNIEVRLKESA-EFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 445 -----SAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSE----------NISAN 489
S Q + +L T + +++ QE+ KIA E ++ ++ A
Sbjct: 1037 KKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Query: 490 KGFSRKSIMTSAEGKHKEPPVKRSRS--LSPKSSFTDSEELQK--LRKAERKIENLEKAL 545
+ + ++ +H E +++ S L K+S+ + E + K + K + E+LEK
Sbjct: 1097 QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQN 1156
Query: 546 QLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQ 605
+L + ++L D + N ++ E+ K E+ + EI + R + +
Sbjct: 1157 RLLHDQIEKLSDKVVASVKEGVQGPLNV-SLSEEGKSQEQ---ILEILRFIRREKEIAET 1212
Query: 606 EDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQL 665
A L Y R+ EL LE EL EL+ ++ ++ +Q + +A+ E+L
Sbjct: 1213 RFEVAQVESLRY--RQRVEL------LERELQELQDSLNAEREKVQVTAKTMAQH--EEL 1262
Query: 666 FRSGEDDEVKRSTPE--KNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKEND 723
+ E V T + + KE LEQ LQ +++ +++ E L+E N +L +++
Sbjct: 1263 MKKTETMNVVMETNKMLREEKERLEQDLQ---QMQAKVRKLELDILPLQEANAELSEKSG 1319
Query: 724 FLKSLLKQQQEDTETREKELEQIIKGSKDVEKEN-----TELQV---KISELETEVTSLR 775
L++ K +ED + + + ++ KD + E +E +V +I +L E+ L+
Sbjct: 1320 MLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLK 1379
Query: 776 RQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKK 835
++A +NA N+ LI ++ + ++ ++E T++ D K + K K +
Sbjct: 1380 AEIARSNASLTNNQNLIQSLK---EDLNKVRTEKETIQ---KDLDAKIIDIQEKVKTITQ 1433
Query: 836 NCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKIS 895
+GR + +K + E ++SS D + Q + V+ Q++
Sbjct: 1434 VKKIGRRYKTQYEELKAQQDKV-------METSAQSSGDHQEQ------HVSVQEMQELK 1480
Query: 896 PTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKS 955
T ++T+ K + N+ + +N ++ T Q ++ +
Sbjct: 1481 ET-----------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLR 1529
Query: 956 SHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEV 1015
T + + IT ++ + R+ I++ + + + L K +E K+
Sbjct: 1530 QDLQDRTTQEEQLRQQITEKEEKT-----RKAIVAAKSKIAHLAGVKDQLTKENEELKQR 1584
Query: 1016 NEKLLHQQQVSDQRFQTSRQTIK-KLNLDLAGLRKEKEDLLKKLESSSEITS-LAEENSQ 1073
N L Q+ D R + + +++ LR+ +E L++ + E ++ + E+ Q
Sbjct: 1585 NGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
Query: 1074 VT 1075
+T
Sbjct: 1645 IT 1646
Score = 50.4 bits (119), Expect = 1e-05
Identities = 61/254 (24%), Positives = 114/254 (44%), Gaps = 30/254 (11%)
Query: 92 ISVEEAMVTRTQLLEEELSSLKEELA-----------LCQADKEFVWSLWKRLQVTNPDL 140
+S +E R Q L EE+ LK E+A L Q+ KE + + + DL
Sbjct: 1358 LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL 1417
Query: 141 TQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEE 200
+ + E+ K ++ K Q ++ K Q+ + E+ Q D ++ ++V E
Sbjct: 1418 DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSA-QSSGDHQEQHVSVQEM 1476
Query: 201 NAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLND 260
L++ + E K K ++++ ++ + KE + R NL+E+ +L + + L D
Sbjct: 1477 QE-LKETLNQAETKSKSLESQVENLQKTLSEKETEAR----NLQEQTVQLQSELSRLRQD 1531
Query: 261 LEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALS---LQLSNKQTEL 317
L+ QE LR++ T+ + KT RK + ++SK L+ QL+ + EL
Sbjct: 1532 LQDRTTQEEQLRQQ--ITEKEEKT--------RKAIVAAKSKIAHLAGVKDQLTKENEEL 1581
Query: 318 IQKDMDITLVRKEL 331
Q++ + + EL
Sbjct: 1582 KQRNGALDQQKDEL 1595
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 135 bits (340), Expect = 3e-31
Identities = 239/1137 (21%), Positives = 464/1137 (40%), Gaps = 120/1137 (10%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
EREK+ + K+ ++ E L+ +A+ +E E++ L QE NDL + A + A +
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
L K ++K+ E ++++EE N L + +KL C++L D++ L
Sbjct: 904 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNA----ELTAKKRKLEDECSELKRDIDDLEL 959
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
A + KEK++T+ K+K + + + + + AL E Q+ +D
Sbjct: 960 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ--------EAHQQALDD-- 1009
Query: 327 VRKELQELQNLYKQNSTHTAQQAEL---IQQLQVLNMDTQKVLRNQEDVHTAESISYQKL 383
++ E ++ L K Q +L ++Q + + MD ++ R E S L
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Query: 384 YNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPD 443
N+ E K + L ++D+ + ++L++KL+E Q L +E + +
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDE----QALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 444 YSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEG 503
+A+ + +E L E+E + E+L+ A S I NK R++
Sbjct: 1126 RTAR-------AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK--KREAEFQKMRR 1176
Query: 504 KHKEPPVKRSRSLSP-KSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR 562
+E ++ + + + DS + + +I+NL++ Q +E E
Sbjct: 1177 DLEEATLQHEATAAALRKKHADS-----VAELGEQIDNLQRVKQKLEKEKSEF------- 1224
Query: 563 KERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
K L + +N + + + K+ R Q+ + S A + R
Sbjct: 1225 KLELDDVTSNMEQIIK---------AKANLEKMCRTLEDQMNEHRSKAEETQ-----RSV 1270
Query: 623 QELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEK- 681
+L Q+ L+ E EL + +A I +L R +L + + +++KR E+
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTR-------GKLTYTQQLEDLKRQLEEEV 1323
Query: 682 NGKEMLEQTLQKVTELENRLKS-FEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETRE 740
K L LQ + L+ +E+ + E + L K N + + + D R
Sbjct: 1324 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1383
Query: 741 KELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQ 800
+ELE+ K + + E + + + + +SL + + L+NE E+L+ +E+S+
Sbjct: 1384 EELEE---AKKKLAQRLQEAEEAVEAVNAKCSSLEKT---KHRLQNEIEDLMVDVERSNA 1437
Query: 801 SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNC-SVGRHHTVLNHSIKVMSNVFEN 859
+A A + + +D K K++ ++ S + L+ + + N +E
Sbjct: 1438 AA-------AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1490
Query: 860 LSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEI 919
S + E + + + + S L + + + I E + Q E++ E Q+ +E
Sbjct: 1491 -SLEHLETFKRENKNLQEEISD-LTEQLGSSGKTIHELEKVRKQLEAEKME-LQSALEEA 1547
Query: 920 VQTYLNIDGKTPKDYFHDKNAKKPTFQK---KNCKMQKSSHTAVPTRVNREKYKNITAQK 976
+ + +GK + K +K K+ +M+++ + RV ++ A+
Sbjct: 1548 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL--RVVDSLQTSLDAET 1605
Query: 977 SSSNIIL---------LRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSD 1027
S N L L E I L N + A+K + K+ +L + +D
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1665
Query: 1028 QRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQV-----T 1082
+ ++ NL L+ E E+L +E + LAE+ T R+Q+ T
Sbjct: 1666 DLKENIAIVERRNNL----LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1721
Query: 1083 SL-SPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMER 1141
SL + + MD ++ QLQ +++ A E K + E +K+ + + +ER
Sbjct: 1722 SLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1781
Query: 1142 DITMKRHLIEDLKFR----QKVNLESNKSFSEMLQNLDKKVKTLTEEC-SNKKVSIDSLK 1196
I+DL+ R +++ L+ K + LQ L+ +V+ L E + +K + +S+K
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGGK---KQLQKLEARVRELENELEAEQKRNAESVK 1838
Query: 1197 QRLNVAVKEKSQYEQMYQKSKEELEKKDL--KLTLLVSRIS-ETESAMAEIETAASK 1250
+ K Q + K L +DL KL L V + E A + T SK
Sbjct: 1839 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1895
Score = 107 bits (268), Expect = 6e-23
Identities = 196/936 (20%), Positives = 383/936 (40%), Gaps = 97/936 (10%)
Query: 492 FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENL---EKALQLK 548
F K ++ SAE + KE + K + SE +K + E K+ +L + LQL+
Sbjct: 834 FKIKPLLKSAE-REKEMASMKEEFTRLKEALEKSEARRK--ELEEKMVSLLQEKNDLQLQ 890
Query: 549 SQ-ENDELRDAHEKRKERLQ---MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
Q E D L DA E+ + ++ L+ + + E+L+ EE + +K K D
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEE---LDELKVHISIDKAAIQELNRCVAERR 661
+ D D + LA ++E + NL EE LDE+ ++ +K A+QE ++ +
Sbjct: 951 KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1010
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ E+D+V T K E L+ E E +++ +R+++ EG+ KL +E
Sbjct: 1011 Q------AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 722 NDF-LKSLLKQQQEDTETREKELEQIIKGSKD-------VEKENTELQVKISELETEVTS 773
+ L++ +Q E + ++ EL + +D ++K+ ELQ +I ELE E+ +
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 774 LRRQVAEANALRNE-NEELINPMEKSHQSADRAKSEMATMKVRSGRYD-CKTTMTKVKFK 831
R A+ LR++ + EL E+ ++ ++ K R + + + + +
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1184
Query: 832 AAKKNCSVGRHHT----VLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTII 887
++ + H L I + V + L K+ SE + + TS I
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK----SEFKLELDDVTSNMEQIIK 1240
Query: 888 VETS-QKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQ 946
+ + +K+ T + + + E++Q +D +++ Q
Sbjct: 1241 AKANLEKMCRTLEDQMNEHRSKAEETQRS-------------------VNDLTSQRAKLQ 1281
Query: 947 KKNCKM--QKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKT 1004
+N ++ Q A+ +++ R K Q+ L E + + LQ+A+
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTY--TQQLEDLKRQLEEEVKAKNALAHALQSARHD 1339
Query: 1005 AELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEI 1064
+L ++Y+E E Q+V + Q K D +E E+ KKL
Sbjct: 1340 CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR--- 1396
Query: 1065 TSLAEENSQVTFPRIQVTSLSPSRS-MDLEMKQLQYKLKN---ATNELTKQSSNVKTLKF 1120
L E V + +SL ++ + E++ L ++ A L K+ N +
Sbjct: 1397 --LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454
Query: 1121 ELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKT 1180
E K E + E + R ++ + + LK + +LE ++F +NL +++
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTE---LFKLKNAYEESLEHLETFKRENKNLQEEISD 1511
Query: 1181 LTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESA 1240
LTE+ + +I L++ EK + + ++++ LE ++ K ++ E
Sbjct: 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGK---ILRAQLEFNQI 1568
Query: 1241 MAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRR 1300
AEIE ++LA + E++ + + L + V +L L +
Sbjct: 1569 KAEIE-------RKLAEKDEEMEQAKRNHLRV-----------VDSLQTSLDAETRSRNE 1610
Query: 1301 QIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDK 1360
+R KKM+ + + + A +AA +S + DT+ Q++ + A +D
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLD---DAVRANDDL 1667
Query: 1361 EWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKLVE 1396
+ + I + L L AV+E+ +KL E
Sbjct: 1668 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703
Score = 97.1 bits (240), Expect = 1e-19
Identities = 180/787 (22%), Positives = 326/787 (41%), Gaps = 126/787 (16%)
Query: 87 RRLEG---ISVEEAMVTRT--QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL- 140
R+LEG ++ E M Q L+E L EL A E +L +LQ +L
Sbjct: 1053 RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Query: 141 TQVVSLVVEREKQKS-EAKDRKVLEILQVKDAKIQE-FEQRESVLKQEINDLVKR----- 193
++ L E E +++ AK K+ L + +I E E+ +I KR
Sbjct: 1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 194 KIAVDEENAFLRKEFSD--LEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLS 251
K+ D E A L+ E + L KK D E+ + + +Q +++ LE+E +
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK-------LEKEKSEFK 1225
Query: 252 TRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLS 311
D+ +++E++ K +A+L K +T ED + E R + E +Q N L+ Q +
Sbjct: 1226 LELDDVTSNMEQIIKAKANLEK-------MCRTLEDQMNEHRSKAEETQRSVNDLTSQRA 1278
Query: 312 NKQTE-------LIQKDMDIT-LVRKEL---QELQNLYKQNSTHTAQQAELIQQLQVLNM 360
QTE L +K+ I+ L R +L Q+L++L +Q + L LQ
Sbjct: 1279 KLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARH 1338
Query: 361 DTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENA 420
D +LR Q + T Q++ ++ + + + Q T + +Q+ +E
Sbjct: 1339 DCD-LLREQYEEETEAKAELQRVLSKAN----------SEVAQWRTKYETDAIQRTEELE 1387
Query: 421 KLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANE 480
+ K+KL + QE++ A SSLE ++EIE L ++ +N
Sbjct: 1388 EAKKKLAQRL-------QEAEEAVEAV---NAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1437
Query: 481 KLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKA-ERKIE 539
+ + F + AE K K + S K + + S EL KL+ A E +E
Sbjct: 1438 AAAALDKKQRNFDK----ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Query: 540 NLEKALQLKSQENDELRD-----------AHEKRKERLQM------LQTNYRAVKEQLKQ 582
+LE + +E+ D HE K R Q+ LQ+ + L+
Sbjct: 1494 HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH 1553
Query: 583 WEEGS---GMTEIRKIKRADPQQLRQEDS-------------DAVWNELAYFKRENQELM 626
EEG E +IK ++L ++D D++ L R E +
Sbjct: 1554 -EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 1612
Query: 627 IQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKR-STPEKNGKE 685
K +E +L+E+++ +S NR AE ++ +VK + K+ +
Sbjct: 1613 RVKKKMEGDLNEMEIQLS-------HANRMAAEAQK----------QVKSLQSLLKDTQI 1655
Query: 686 MLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQ 745
L+ ++ +L+ + E+R N L E + L+++++Q + + E+EL +
Sbjct: 1656 QLDDAVRANDDLKENIAIVERR-------NNLLQAELEELRAVVEQTERSRKLAEQELIE 1708
Query: 746 IIKGSKDVEKENTELQVKISELETEVTSLRRQVAEA-NALRNENEELINPMEKSHQSADR 804
+ + + +NT L + +++ +++ L+ +V EA RN E+ + + A+
Sbjct: 1709 TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1768
Query: 805 AKSEMAT 811
K E T
Sbjct: 1769 LKKEQDT 1775
Score = 94.7 bits (234), Expect = 5e-19
Identities = 152/740 (20%), Positives = 306/740 (41%), Gaps = 143/740 (19%)
Query: 99 VTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK 158
+T TQ LE+ L+EE+ A L LQ D L+ E+ ++++EAK
Sbjct: 1306 LTYTQQLEDLKRQLEEEVKAKNA-------LAHALQSARHDC----DLLREQYEEETEAK 1354
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
A++Q VL + +++ + + + + +E + +KK +
Sbjct: 1355 ------------AELQR------VLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396
Query: 219 SQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYST 278
QE ++ E V K +LE+ +L DL+ D+E+ A L K++ +
Sbjct: 1397 LQEAEEAVEAVNAK-------CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNF 1449
Query: 279 DAKIKTFEDNLIEARKEVEVSQSKYNALSLQL---SNKQTELIQKDMDITLVRKELQE-L 334
D + ++ E++ E+E SQ + +LS +L N E ++ K LQE +
Sbjct: 1450 DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1509
Query: 335 QNLYKQ--NSTHTAQQAELIQ-QLQVLNMDTQKVLRNQE---DVHTAESISYQKLYNELH 388
+L +Q +S T + E ++ QL+ M+ Q L E + + + Q +N++
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQI- 1568
Query: 389 ICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAP-------LPLPQESD 441
+A + + + +++ Q ++ + ++ + LQ S A L + ++ +
Sbjct: 1569 ---------KAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKME 1619
Query: 442 PDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSA 501
D + LS + + +++ LQ LK +L + + AN +
Sbjct: 1620 GDLNEM---EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1676
Query: 502 EGKHKEPPVKRSRSLSPKSSFTDSEELQKLRK-AERKIENLEKALQLKSQENDELRDAHE 560
+ ++ R++ E+ ++ RK AE+++ + +QL +N L + +
Sbjct: 1677 RNNLLQAELEELRAVV--------EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK 1728
Query: 561 KRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKR 620
K L LQT ++ + EE K K+A D+ + EL +
Sbjct: 1729 KMDADLSQLQTEVEEAVQECRNAEE--------KAKKAIT------DAAMMAEELKKEQD 1774
Query: 621 ENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPE 680
+ L K N+E+ + +L+ + D+A EQ+ G
Sbjct: 1775 TSAHLERMKKNMEQTIKDLQHRL--DEA--------------EQIALKG----------- 1807
Query: 681 KNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETRE 740
GK+ L++ +V ELEN L++ +KR+ + +G +K + +K L Q +ED
Sbjct: 1808 --GKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERR---IKELTYQTEED----- 1857
Query: 741 KELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNEN----EELINPME 796
K LQ + +L+ +V + +RQ EA N N ++ + ++
Sbjct: 1858 -------------RKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Query: 797 KSHQSADRAKSEMATMKVRS 816
++ + AD A+S++ ++ +S
Sbjct: 1905 EAEERADIAESQVNKLRAKS 1924
Score = 57.4 bits (137), Expect = 1e-07
Identities = 65/315 (20%), Positives = 135/315 (42%), Gaps = 34/315 (10%)
Query: 88 RLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQV-------TNPDL 140
R E + V++ M +E +LS A Q + + SL K Q+ N DL
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 141 TQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEE 200
+ ++ +VER +A+ L+ A +++ E+ + +QE+ + +R + +
Sbjct: 1668 KENIA-IVERRNNLLQAE-------LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQ 1719
Query: 201 NAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLND 260
N L + +K D SQ + +E VQ +N EE+ KK T + +
Sbjct: 1720 NTSL---INQKKKMDADLSQLQTEVEEAVQE--------CRNAEEKAKKAITDAAMMAEE 1768
Query: 261 LEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEA--------RKEVEVSQSKYNALSLQLSN 312
L+K + AHL + K + + IK + L EA +K+++ +++ L +L
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828
Query: 313 KQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDV 372
+Q + + + ++EL +++ + + +L+ +LQ+ ++ E+
Sbjct: 1829 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888
Query: 373 HTAESISYQKLYNEL 387
++K+ +EL
Sbjct: 1889 ANTNLSKFRKVQHEL 1903
Score = 43.9 bits (102), Expect = 0.001
Identities = 55/278 (19%), Positives = 122/278 (43%), Gaps = 52/278 (18%)
Query: 90 EGISVEEAMVTRTQLLEEELSSLKEELALCQ-----ADKEFVWSLWKRLQVTNPDLTQVV 144
E I++ E R LL+ EL L+ + + A++E + + +R+Q+ + +Q
Sbjct: 1669 ENIAIVER---RNNLLQAELEELRAVVEQTERSRKLAEQELIETS-ERVQLLH---SQNT 1721
Query: 145 SLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFL 204
SL+ +++K ++ + +V++A +QE E K+ I D + +E
Sbjct: 1722 SLINQKKKMDADLSQLQT----EVEEA-VQECRNAEEKAKKAITDAAMMAEELKKE---- 1772
Query: 205 RKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEK- 263
+ + LE+ K+ Q IKD + + +E ++ +K +++ +KL R +L N+LE
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRL---DEAEQIALKGGKKQLQKLEARVRELENELEAE 1829
Query: 264 ----------LRKQEAHLRKEKYSTDA-----------------KIKTFEDNLIEARKEV 296
+RK E +++ Y T+ K+K ++ EA ++
Sbjct: 1830 QKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1889
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQEL 334
+ SK+ + +L + + + +R + +++
Sbjct: 1890 NTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 135 bits (339), Expect = 4e-31
Identities = 237/1163 (20%), Positives = 484/1163 (41%), Gaps = 173/1163 (14%)
Query: 149 EREKQKSEAKDR--KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ ++ E L+ +A+ +E E++ L QE NDL ++ V E L
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDL---QLQVQAEQDNLND 902
Query: 207 EFSDLEKKFKDKSQ---EIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEK 263
++ K+K Q ++K+ E ++++EE N L + +KL C++L D++
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA----ELTAKKRKLEDECSELKKDIDD 958
Query: 264 LRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMD 323
L A + KEK++T+ K+K + + + + + AL E Q+ +D
Sbjct: 959 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ--------EAHQQALD 1010
Query: 324 ITLVRKELQELQNLYKQNSTHTAQQAEL---IQQLQVLNMDTQKVLRNQEDVHTAESISY 380
V ++ ++ +L K Q +L ++Q + + MD ++ R E S
Sbjct: 1011 DLQVEED--KVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 381 QKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQES 440
L N+ E K E + Q + ++D+ + Q L++KL+E+Q L +E
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQ----LQKKLKENQARIEELEEEL 1124
Query: 441 DPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTS 500
+ + +A+ + +E L E+E + E+L+ A S I NK R++
Sbjct: 1125 EAERTAR-------AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK--KREAEFQK 1175
Query: 501 AEGKHKEPPVKRSRSLSP-KSSFTDS-----EELQKLRKAERKIENLEKALQLKSQENDE 554
+E ++ + + + DS E++ L++ ++K+E + +L+ +
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1235
Query: 555 LRDAHEKRKERLQML------QTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQ-ED 607
+ K K L+ + Q N VK + Q T+ K++ + + RQ E+
Sbjct: 1236 NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE 1295
Query: 608 SDAVWNELAYFKRE-NQELMIQKMNLEEE-----------------LDELKVHISIDKAA 649
+A+ ++L K Q++ K LEEE D L+ + A
Sbjct: 1296 KEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA 1355
Query: 650 IQELNRCVAERREE--QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTE----LENRLKS 703
EL R +++ E Q E D ++R+ + K+ L Q LQ E + + S
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 704 FEKRSRKLKEGNKKLM---------------KENDFLKSLLKQQQEDTETREKELEQIIK 748
EK +L+ + LM K+ +F K L + +Q+ E+ + ELE K
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES-QSELESSQK 1474
Query: 749 GSKDVEKENTEL----QVKISELET---EVTSLRRQVAEANALRNENEELINPMEKSHQS 801
++ + E +L + + LET E +L+ ++++ E + ++ +EK
Sbjct: 1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKV--- 1531
Query: 802 ADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLS 861
R + E+ ++++S + + ++ + K + + + + E
Sbjct: 1532 --RKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1589
Query: 862 KDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQ 921
++ V + +A+T + V K + E D E EI
Sbjct: 1590 RNHQRVVDSLQTSLDAETRSRNEVLRV------------KKKMEGDLNE------MEIQL 1631
Query: 922 TYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNI 981
++ N + K K K+ ++Q R N + +NI + +N+
Sbjct: 1632 SHANRMAAEAQ-----KQVKSLQSLLKDTQIQLDD----AVRANDDLKENIAIVERRNNL 1682
Query: 982 ILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEK--LLHQQQVS--DQRFQTSRQTI 1037
+ L++ +V++ +++ +L+ +E E +E+ LLH Q S +Q+
Sbjct: 1683 LQ-----AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK-------- 1729
Query: 1038 KKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRI---QVTSLSPSR---SMD 1091
KK+ DL L+ E E+ +++ ++ E A ++ + + Q TS R +M+
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789
Query: 1092 LEMKQLQYK--------LKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDI 1143
+K LQ++ LK +L K + V+ L+ EL A+++ E + + + ER I
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI 1849
Query: 1144 TM--------KRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSL 1195
K++L+ K+ L+ K++ + +++ T + + +D
Sbjct: 1850 KELTYQTEEDKKNLLRLQDLVDKLQLKV-KAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1908
Query: 1196 KQRLNVAVKEKSQYEQMYQKSKE 1218
++R ++A +SQ ++ KS++
Sbjct: 1909 EERADIA---ESQVNKLRAKSRD 1928
Score = 110 bits (275), Expect = 1e-23
Identities = 194/948 (20%), Positives = 392/948 (41%), Gaps = 106/948 (11%)
Query: 492 FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENL---EKALQLK 548
F K ++ SAE + KE + K + SE +K + E K+ +L + LQL+
Sbjct: 836 FKIKPLLKSAETE-KEMATMKEEFGRIKETLEKSEARRK--ELEEKMVSLLQEKNDLQLQ 892
Query: 549 SQ-ENDELRDAHEKRKERLQ---MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
Q E D L DA E+ + ++ L+ + + E+L+ EE + +K K D
Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEE---LDELKVHISIDKAAIQELNRCVAERR 661
++D D + LA ++E + NL EE LDE+ ++ +K A+QE ++ +
Sbjct: 953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1012
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ E+D+V + K E L+ E E +++ +R+++ EG+ KL +E
Sbjct: 1013 QV------EEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1066
Query: 722 NDF--------LKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTS 773
+ L+ LK+++ D + ++E + ++K+ E Q +I ELE E+ +
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126
Query: 774 LRRQVAEANALRNE-NEELINPMEKSHQSADRAKSEMATMKVRSG-----RYDCKTTMTK 827
R A+ LR++ + EL E+ ++ ++ K R R D + +
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1186
Query: 828 VKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTII 887
+ AA L I + V + L K + SE + + TS I
Sbjct: 1187 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK----EKSEFKLELDDVTSNMEQIIK 1242
Query: 888 VETS-QKISPTEDGKDQKESDPTEDSQTQGKEIV--QTYLNIDGKTPKDYFHDKNAKKPT 944
+ + +K+S T + + + E++Q + + L + +K A
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQ 1302
Query: 945 FQKKNCKMQKSSHTAVPTRVNREKYKNITA---QKSSSNIILLRERIISLQQQNSVLQNA 1001
+ + K KN A Q + + LLRE+ + + LQ
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1362
Query: 1002 KKTAELSVKEYK--------EVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKED 1053
A V +++ + E+L ++ QR Q + + ++ +N + L K K
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 1054 LLKKLE------SSSEITSLAEENSQVTFPRIQV-------TSLSPSRSMDLEMKQLQYK 1100
L ++E S + A + Q F +I S S S E + L +
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1482
Query: 1101 LKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDI-----TMKRHLIEDLKF 1155
L N + +++T K E +E I ++ E++ +++ K+ +E L+
Sbjct: 1483 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 1156 RQ-----------------KVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQR 1198
+ + LE N+ +E+ + L +K + + + N + +DSL+
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 1199 LNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQ 1258
L+ + +++ ++ +K + +L + +++L+ +E + + K LQ L
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV--------KSLQSLLKD 1654
Query: 1259 SEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKK--NRDACK 1316
++ L+ A + AN+ ++E V+ LQ ++ +R + + ++ +K ++ +
Sbjct: 1655 TQIQLDDAVR----ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1710
Query: 1317 TSTHKAQTLAA---SILNISRSDLEEILDTEDQVEIEKTKIDAENDKE 1361
TS + Q L + S++N + +E L T+ Q E+E+ + N +E
Sbjct: 1711 TS-ERVQLLHSQNTSLIN-QKKKMESDL-TQLQSEVEEAVQECRNAEE 1755
Score = 108 bits (270), Expect = 4e-23
Identities = 228/1189 (19%), Positives = 486/1189 (40%), Gaps = 169/1189 (14%)
Query: 200 ENAFLRKEFSDLEKKFKDKSQEIKDT--KECVQNKEEQNRLVIKNLEEENKKLSTRCT-D 256
++A KE + ++++F IK+T K + KE + ++V E+ + +L + D
Sbjct: 843 KSAETEKEMATMKEEFG----RIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQD 898
Query: 257 LLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTE 316
LND E+ Q L K K +AK+K + L + + +K L + S + +
Sbjct: 899 NLNDAEERCDQ---LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKD 955
Query: 317 LIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAE 376
+ ++ + V KE +N K + A E+I +L T++ QE
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL------TKEKKALQE------ 1003
Query: 377 SISYQKLYNELHICFETTKS---NEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAP 433
++Q+ ++L + + S ++ L Q V +L+ L Q+++ L+ ++ +G
Sbjct: 1004 --AHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG-D 1060
Query: 434 LPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFS 493
L L QES D L E L +K E + Q+ KI +E++
Sbjct: 1061 LKLTQESIMDLE-----NDKLQLEEKL---KKKEFDINQQNSKIEDEQV----------- 1101
Query: 494 RKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQE-N 552
+ + K KE + EEL+ R A K+E L L + +E +
Sbjct: 1102 ---LALQLQKKLKENQARIEEL---------EEELEAERTARAKVEKLRSDLSRELEEIS 1149
Query: 553 DELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVW 612
+ L +A +++M + ++ + EE + E A LR++ +D+V
Sbjct: 1150 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE------ATAAALRKKHADSV- 1202
Query: 613 NELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDD 672
A + L K LE+E E K+ + + ++++ + A+ E++ R+ ED
Sbjct: 1203 ---AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK--AKANLEKVSRTLEDQ 1257
Query: 673 EVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQ 732
+ K+ E + L F + KL+ N +L ++ + ++L+ Q
Sbjct: 1258 A--------------NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQL 1303
Query: 733 QEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELI 792
+ +++E + + ++ K L + + LR Q E + E + ++
Sbjct: 1304 TRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1363
Query: 793 NPMEKSHQSADRAKSEMATMKVRSGRYDCKTT--MTKVKFKAAKKNCSVGRHHTVLN--- 847
+ +A SE+A + + + T + + K K A++ +N
Sbjct: 1364 S----------KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKC 1413
Query: 848 HSIKVMSNVFENLSKDGWEDVSESSSDSEA--QTSQTLGTIIVETSQKISPTEDGKDQKE 905
S++ + +N +D DV S++ + A + + I+ E QK ++
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY--------EES 1465
Query: 906 SDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVN 965
E SQ + + + + K+ + + TF+++N +Q
Sbjct: 1466 QSELESSQKEARSLSTELFKL-----KNAYEESLEHLETFKRENKNLQ------------ 1508
Query: 966 REKYKNITAQ--KSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQ 1023
E+ ++T Q + N+ L + L+ + LQ+A + AE S+ E++E K+L Q
Sbjct: 1509 -EEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASL-EHEE--GKILRAQ 1564
Query: 1024 QVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTS 1083
+Q + + + + ++ ++ + ++ L++S + AE S+ R++
Sbjct: 1565 LEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLD----AETRSRNEVLRVK--- 1617
Query: 1084 LSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIK---------EMHE 1134
+ M+ ++ +++ +L +A + VK+L + L K+ I+ ++ E
Sbjct: 1618 ----KKMEGDLNEMEIQLSHANRMAAEAQKQVKSL--QSLLKDTQIQLDDAVRANDDLKE 1671
Query: 1135 KISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECS---NKKVS 1191
I+ +ER + + +E+L+ + S K + L ++V+ L + + N+K
Sbjct: 1672 NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKK 1731
Query: 1192 IDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAAS-- 1249
++S +L V+E Q + ++E+ +K ++ + + + A +E
Sbjct: 1732 MESDLTQLQSEVEEA---VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1788
Query: 1250 ----KQLQELALQSEQV-LEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRE 1304
K LQ ++EQ+ L+G +K L +V E ++A K V +R+ R
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848
Query: 1305 LKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTK 1353
+K++ + K + + Q L + ++ + + E+Q +K
Sbjct: 1849 IKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1897
Score = 99.8 bits (247), Expect = 2e-20
Identities = 198/1015 (19%), Positives = 396/1015 (39%), Gaps = 164/1015 (16%)
Query: 89 LEGISVEEAMVTRTQL----LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL--TQ 142
L+ + VEE V LE+++ L+ L + +K+ L + + DL TQ
Sbjct: 1009 LDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSL---EQEKKVRMDLERAKRKLEGDLKLTQ 1065
Query: 143 VVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENA 202
+ +E +K + E K +K + +++KI++ + L++++ + R ++EE
Sbjct: 1066 ESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELE 1125
Query: 203 FLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLE 262
R + +EK D S+E+++ E ++ + I E NKK + DLE
Sbjct: 1126 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI----EMNKKREAEFQKMRRDLE 1181
Query: 263 KLRKQE----AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
+ Q A LRK+ + A++ DNL ++++E +S++ +++ ++I
Sbjct: 1182 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1241
Query: 319 QKDMDITLVRKELQELQNLYK------QNSTH--TAQQAELIQQLQVLNMDTQKVLRNQE 370
+ ++ V + L++ N Y+ Q S + T Q+A +LQ N + + L +E
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KLQTENGELARQLEEKE 1297
Query: 371 DV---HTAESISYQKLYNELHICFE---TTKSNEAMLRQSVTNLQDQLLQKEQENAKLKE 424
+ T +SY + +L E K+ A QS + D L ++ +E + K
Sbjct: 1298 ALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKA 1357
Query: 425 KLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLS- 483
+LQ + Y R LE ++ +E ++ N K S
Sbjct: 1358 ELQRVLSKANSEVAQWRTKYETDAIQR--TEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 484 -ENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTD---SEELQKLRKAERKIE 539
E + +M E + + +L K D +E QK +++ ++E
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSN-----AAAAALDKKQRNFDKILAEWKQKYEESQSELE 1470
Query: 540 NLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEE--GSGMTEIRKIKR 597
+ +K + S E +L++A+E+ E L+ + + ++E++ E G G + ++++
Sbjct: 1471 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEK 1530
Query: 598 ADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAI----QEL 653
++L ++K+ L+ L+E + + ++ I E
Sbjct: 1531 V-----------------------RKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF 1567
Query: 654 NRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKE 713
N+ AE + + E ++ KR+ + + +LQ + E R ++ R +K E
Sbjct: 1568 NQIKAEIERKLAEKDEEMEQAKRN------HQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621
Query: 714 GNKKLM---------------KENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENT 758
G+ M K+ L+SLLK Q + + + + + VE+ N
Sbjct: 1622 GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1681
Query: 759 ELQVKISELE--TEVTSLRRQVAE---------ANALRNENEELINPMEKSHQSADRAKS 807
LQ ++ EL E T R++AE L ++N LIN +K + +S
Sbjct: 1682 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS 1741
Query: 808 EMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWED 867
E V +C+ K K +I + + E L K
Sbjct: 1742 E-----VEEAVQECRNAEEKAK------------------KAITDAAMMAEELKK----- 1773
Query: 868 VSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNID 927
E TS L + Q I + D+ E + + Q +++ ++
Sbjct: 1774 --------EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1825
Query: 928 GKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQ--KSSSNIILLR 985
G+ + QK+N + K R + + K +T Q + N++ L+
Sbjct: 1826 GELEAE------------QKRNAESVKG------MRKSERRIKELTYQTEEDKKNLLRLQ 1867
Query: 986 ERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKL 1040
+ + LQ + + + AE K+ H+ +++R + + KL
Sbjct: 1868 DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1922
Score = 90.5 bits (223), Expect = 1e-17
Identities = 131/646 (20%), Positives = 271/646 (41%), Gaps = 107/646 (16%)
Query: 199 EENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLL 258
E +A R E +LE+ K +Q ++D +E V+ + +LE+ +L DL+
Sbjct: 1378 ETDAIQRTE--ELEEAKKKLAQRLQDAEEAVEAVNAK----CSSLEKTKHRLQNEIEDLM 1431
Query: 259 NDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
D+E+ A L K++ + D + ++ E++ E+E SQ + +LS +L +
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK---- 1487
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESI 378
+ L+ L+ ++N + ++L +QL ++VH E +
Sbjct: 1488 ------NAYEESLEHLETFKRENKNLQEEISDLTEQLG----------EGGKNVHELEKV 1531
Query: 379 SYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQ 438
Q +L + + EA L + L+ Q A+++ KL E
Sbjct: 1532 RKQLEVEKLEL-QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE---------- 1580
Query: 439 ESDPDYSAQVPHRPSLSSLET-LMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSI 497
+ + A+ H+ + SL+T L +S E L+ K K+
Sbjct: 1581 KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKM-------------------- 1620
Query: 498 MTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRD 557
EG E ++ S ++ +E ++++ + +++ + L + ND+L++
Sbjct: 1621 ----EGDLNEMEIQLSH-----ANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE 1671
Query: 558 AHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAY 617
+ R +LQ ++ ++Q E + E I+ ++ QL + ++ N+
Sbjct: 1672 NIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK-- 1729
Query: 618 FKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRS 677
K+ +L + +EE + E + K AI + E ++EQ D
Sbjct: 1730 -KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ------DTSAHLE 1782
Query: 678 TPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTE 737
+KN +EQT++ +L++RL E+ + LK G K+L K L++ +++ + + E
Sbjct: 1783 RMKKN----MEQTIK---DLQHRLDEAEQIA--LKGGKKQLQK----LEARVRELEGELE 1829
Query: 738 TREKELEQIIKGSKDVEKENTE--------------LQVKISELETEVTSLRRQVAEANA 783
+K + +KG + E+ E LQ + +L+ +V + +RQ EA
Sbjct: 1830 AEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1889
Query: 784 LRNEN----EELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTM 825
N N ++ + ++++ + AD A+S++ ++ +S K M
Sbjct: 1890 QANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKM 1935
Score = 55.8 bits (133), Expect = 3e-07
Identities = 79/393 (20%), Positives = 157/393 (39%), Gaps = 66/393 (16%)
Query: 95 EEAMVTRTQL--------LEEELSSLKEELALCQADKE-FVWSLWKRLQVTNPDLTQVVS 145
EE + R QL +E +L+ EE+ + + + V SL L +V+
Sbjct: 1556 EEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR 1615
Query: 146 LVVEREKQKSE------------AKDRKVLEILQ--VKDAKIQ--EFEQRESVLKQEIND 189
+ + E +E A+ +K ++ LQ +KD +IQ + + LK+ I
Sbjct: 1616 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 190 LVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVI--------- 240
+ +R + E LR E+ K QE+ +T E VQ QN +I
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESD 1735
Query: 241 ---------------KNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTF 285
+N EE+ KK T + +L+K + AHL + K + + IK
Sbjct: 1736 LTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1795
Query: 286 EDNLIEA--------RKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNL 337
+ L EA +K+++ +++ L +L +Q + + + ++EL
Sbjct: 1796 QHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQ 1855
Query: 338 YKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSN 397
+++ + + +L+ +LQ+ ++ E+ ++K+ +EL +
Sbjct: 1856 TEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL---------D 1906
Query: 398 EAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQ 430
EA R + Q L+ + + K+K+ + +
Sbjct: 1907 EAEERADIAESQVNKLRAKSRDIGAKQKMHDEE 1939
Score = 55.5 bits (132), Expect = 4e-07
Identities = 95/489 (19%), Positives = 204/489 (41%), Gaps = 54/489 (11%)
Query: 954 KSSHTAVPTRVNREKYKNI--TAQKSSSNIILLRERIISLQQQNSVLQ-----------N 1000
KS+ T +E++ I T +KS + L E+++SL Q+ + LQ +
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902
Query: 1001 AKKTAELSVK-------EYKEVNEKLLHQQQVSDQRFQTSRQT----------IKKLNLD 1043
A++ + +K + KE+NE+L +++++ + R+ I L L
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 1044 LAGLRKEKEDLLKKLES-SSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLK 1102
LA + KEK K+++ + E+ L E +++T + + DL++++ K+
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEE--DKVN 1020
Query: 1103 NATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLE 1162
+ + K V L+ L +++ ++ ++E D+ + + I DL+ K+ LE
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE-NDKLQLE 1079
Query: 1163 SN---KSFSEMLQNL---DKKVKTLT--EECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
K F QN D++V L ++ + I+ L++ L +++ E++
Sbjct: 1080 EKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRS 1139
Query: 1215 KSKEELEKKDLKLT----LLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTL 1270
ELE+ +L +I + AE + + L+E LQ E +K
Sbjct: 1140 DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMR-RDLEEATLQHEATAAALRKKH 1198
Query: 1271 LLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASIL 1330
+ ++ E ++ + ++L+ + + ++ ++ + K + K
Sbjct: 1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258
Query: 1331 NISRSDLEEILDTEDQVEIEKTKIDAEND------KEWMLYIQKLLEGQLPFASYLLEAV 1384
N R LEE + + ++ K+ EN +E I +L G+L + +E +
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQ-MEDL 1317
Query: 1385 LEKINEKKK 1393
++ E+ K
Sbjct: 1318 KRQLEEEGK 1326
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 134 bits (338), Expect = 5e-31
Identities = 254/1323 (19%), Positives = 568/1323 (42%), Gaps = 168/1323 (12%)
Query: 87 RRLEGISVE-EAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVS 145
+RL+ ++ E + + +T L+ E+ SL +E L Q +E L ++L+V + ++
Sbjct: 435 QRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE---ELRQQLEVLEQEAWRLRR 491
Query: 146 LVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVL-------KQEINDLVKRKIAVD 198
+ VE + Q A+ +K + ++ A ++E E+ + +L + +++L+ + A++
Sbjct: 492 VNVELQLQGDSAQGQKEEQQEELHLA-VRERERLQEMLMGLEAKQSESLSELITLREALE 550
Query: 199 E---ENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCT 255
E LR+E +++ Q I + + + E + + +L KLS
Sbjct: 551 SSHLEGELLRQEQTEVTAALARAEQSIAE----LSSSENTLKTEVADLRAAAVKLSALNE 606
Query: 256 DLLNDLEKLRKQEAHLRKEKYSTDAKIKTFED-------NLIEARKEVEVSQSKYNALSL 308
L D L +Q L +E S ++++ E +L EA K E K L
Sbjct: 607 ALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEA 666
Query: 309 QLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRN 368
QL + + D+ +++E +E+Q K+ S QQ QL+ L+ + ++
Sbjct: 667 QLQKAEEAGAELQADLRDIQEEKEEIQ---KKLSESRHQQEAATTQLEQLHQEAKR---- 719
Query: 369 QED-----VHTAESISYQKLYNELHI-CFETTKSNEAMLRQSVTN----LQDQLLQKEQE 418
QE+ V E++ +K E+ + E + + A Q +++ L+ L + +Q+
Sbjct: 720 QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQ 779
Query: 419 NAKLK--------------EKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQ 464
N+ ++ + + QG L E D + S R + + +
Sbjct: 780 NSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAA---RQLAQA 836
Query: 465 KSEIEYLQEKLKIANEK----LSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKS 520
+ E + E+ K A+EK L E + + ++ + + E +E K + K
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE---KMELEMRLKE 893
Query: 521 SFTDSEELQKLRKAER-KIENLEKALQLKSQEN-----DELRDAHEKRKERLQMLQTNYR 574
T+ E +Q R+ ER + E+ +QL++++ + L ++ + Q L+ +
Sbjct: 894 QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ 953
Query: 575 AVKEQLKQWEEGSGM--TEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNL 632
+K Q + +E +G+ T++++ +R + RQ D LA + E+ L+ KM+L
Sbjct: 954 DMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD-----LAALQEESSSLLQDKMDL 1008
Query: 633 EEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNG--------K 684
++++++LK + A + R V + +E+L + E + +++ + K
Sbjct: 1009 QKQVEDLKSQL----VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 685 EMLEQTLQKVTEL-ENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKEL 743
E LQ+ + + L + + ++ + K+L + + L+ +K+++ D +E +L
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
Query: 744 EQIIKGSKDVEKE-----------NTELQVKISELETEVTSLRRQVAEANALRNENE--E 790
+ ++ S E++ +LQ+++ E+++ +L + N + + +
Sbjct: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLAS 1184
Query: 791 LINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSI 850
L + ++++ S ++ E+ SG D ++ ++ R + S
Sbjct: 1185 LYSALQQALGSVCESRPEL------SGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSA 1238
Query: 851 KVMSNVFENLSKDGW-------------EDVSESSSDSEAQTSQTLGTIIVETSQKISPT 897
+ +++ L +D W + + E +D+EA+ SQ + T + + +++S
Sbjct: 1239 EAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ-VHTELQDLQRQLSQN 1297
Query: 898 EDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSH 957
++ K + E +++ E+ +T ++ + + A+ +++ + K +
Sbjct: 1298 QEEKSKWEG-KQNSLESELMELHETMASLQSRLRRAELQRMEAQG---ERELLQAAKENL 1353
Query: 958 TAVPTRVNREKYKNITAQKSSSNIIL--LRERIISLQQQNSVLQNAKKTA-------ELS 1008
TA + + AQ S++ I+ LR +L+ +N +++ ++ A EL
Sbjct: 1354 TAQVEHL-QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412
Query: 1009 VKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLA 1068
V + K + E L Q +R + ++ L + L K++E LE S L
Sbjct: 1413 VAQGKALQENLALLTQTLAER----EEEVETLRGQIQELEKQREMQKAALELLS--LDLK 1466
Query: 1069 EENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEH 1128
+ N +V + Q+ L RS+ ++ L ++ +LT Q ++ L+ + +
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSV---LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNV 1523
Query: 1129 IKEMHEKISRMERDITMKRHLIEDLKFRQKVNLE----SNKSFSEMLQNLDKKVKTLTEE 1184
++ ++ + ++ I +R ++DLK +Q V LE + ++ K +K L +
Sbjct: 1524 LEHQLLELEKKDQMIESQRGQVQDLK-KQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582
Query: 1185 CSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEI 1244
++V++ L + ++E+SQ Q +LE T+L + E + +
Sbjct: 1583 RETQRVAL----THLTLDLEERSQELQAQSSQIHDLESHS---TVLARELQERDQEV--- 1632
Query: 1245 ETAASKQLQELALQSE---QVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQ 1301
+ +Q++EL Q E Q LE + L+L E+++ K L+ D+ ++
Sbjct: 1633 -KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLS 1691
Query: 1302 IRE 1304
+RE
Sbjct: 1692 LRE 1694
Score = 127 bits (319), Expect = 8e-29
Identities = 278/1388 (20%), Positives = 567/1388 (40%), Gaps = 179/1388 (12%)
Query: 106 EEELSSLKEELALCQ----ADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRK 161
+ E + E ALCQ +KE V SL + L T +L S +ER +Q + + K
Sbjct: 904 QREEERTQAESALCQMQLETEKERV-SLLETLLQTQKELADA-SQQLERLRQDMKVQKLK 961
Query: 162 VLEILQVKDAKIQEFEQR-ESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQ 220
E + ++QE ++ + +Q +DL A+ EE++ L ++ DL+K
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLA----ALQEESSSLLQDKMDLQK------- 1010
Query: 221 EIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDA 280
+++D K + +++ RLV + ++E+ L + ++ + + L +EK S
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEK-----------LRETQEYNRIQKELEREKASLTL 1059
Query: 281 KIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQ 340
+ E L+ ++ + Q + +AL + Q E + + L+R+E++E +
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE------K 1113
Query: 341 NSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSN-EA 399
+ AQ+A+L+++L+ ++ T++ LR A++ +L + +T+S EA
Sbjct: 1114 EADFLAQEAQLLEELEASHI-TEQQLRASLWAQEAKAA-------QLQLRLRSTESQLEA 1165
Query: 400 MLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLET 459
+ + Q Q + + A L LQ++ G+ ES P+ S PS+ LE
Sbjct: 1166 LAAEQQPGNQ---AQAQAQLASLYSALQQALGSVC----ESRPELSGGGDSAPSVWGLEP 1218
Query: 460 LMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPK 519
+S L ++ + +E +++ + + + + + V R + +
Sbjct: 1219 DQNGARS----LFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD----VLRDQVQKLE 1270
Query: 520 SSFTDSE--------ELQKLRKAERKIENLEKALQLKSQEND---ELRDAHEK------- 561
TD+E ELQ L++ + +N E+ + + ++N EL + HE
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQR--QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 562 -RKERLQMLQTN-----YRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNEL 615
R+ LQ ++ +A KE L E + +A + +ED + L
Sbjct: 1329 LRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSAL 1388
Query: 616 AYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQE----LNRCVAERREEQLFRSGED 671
K E E ++ +E ELKV A+QE L + +AER EE G+
Sbjct: 1389 K-LKNEEVESERERAQALQEQGELKV---AQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 672 DEV-KRSTPEKNGKEMLEQTLQK-----------VTELENRLKSFEKRSRKLKEGNKKLM 719
E+ K+ +K E+L L+K + ELE E ++E +KL
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLT 1504
Query: 720 KENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVA 779
+ + ++ L K ++ E +L ++ K + +E + ++Q +L T + L ++
Sbjct: 1505 VQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT-LECLALELE 1563
Query: 780 EANALRNENEELINPMEK---------SHQSADRAKSEMATMKVRSGRYDCKTTMTKVKF 830
E + ++LI +E +H + D + S +D ++ T +
Sbjct: 1564 ENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAR 1623
Query: 831 KAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVET 890
+ +++ V + + ++ ++L + E + + + +T T I+E
Sbjct: 1624 ELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683
Query: 891 SQ---KISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPK-----DYFHDKNAKK 942
K+S E G++ T ++++Q +GK P H K +
Sbjct: 1684 DLEQIKLSLRERGREL----------TTQRQLMQERAE-EGKGPSKAQRGSLEHMKLILR 1732
Query: 943 PTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRER---IISLQQQNSVLQ 999
++ C+ Q+ H + E+ +K +LL +R I+ LQQQ LQ
Sbjct: 1733 DKEKEVECQ-QEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ---LQ 1788
Query: 1000 NAKKTAEL---SVKEYKEVNEKLLHQQ-------QVSDQRFQTSRQTIKKLNLDLAGLRK 1049
A++ EL S++ + ++ L Q+ Q Q+ Q + +K+ L G +
Sbjct: 1789 EAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848
Query: 1050 EKEDLLKK----LESSSEITSLAEENSQVTFPRIQVTS--LSPSRSMDLEMKQLQYKLKN 1103
+ LK+ L+ E EE V R+Q L R+ E ++ L+
Sbjct: 1849 QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ 1908
Query: 1104 ATNELTKQSS-NVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLE 1162
E ++ + L+ L + +KE +++ + + RH E + R + E
Sbjct: 1909 QCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQE 1968
Query: 1163 SNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEK 1222
+ LQ ++ + E + + S +L+ L+ Q E+ + + E++
Sbjct: 1969 ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQD 2028
Query: 1223 KDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLL-----LANEKV 1277
+DL+ + + + A+A+ + Q + L + + + Q+ ++ L E+
Sbjct: 2029 QDLRYQ---EDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE 2085
Query: 1278 EEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDL 1337
EE + +ELQ + ++I EL++ ++ R+ + H +T ++ L
Sbjct: 2086 EEEIRGLHQSVRELQLTLAQKEQEILELRETQQ-RNNLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 1338 EEILDTE-DQVEIEKTKIDAENDKEWMLYIQKL----------LEGQLPFASYLLEAVLE 1386
E L E ++++ + +A + EW Q L + A +L +VLE
Sbjct: 2145 EPRLQRELERLQAALRQTEA-REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLE 2203
Query: 1387 KINEKKKL 1394
+ +E+++L
Sbjct: 2204 RDSEQQRL 2211
Score = 116 bits (291), Expect = 1e-25
Identities = 237/1298 (18%), Positives = 523/1298 (40%), Gaps = 167/1298 (12%)
Query: 103 QLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK-DRK 161
Q +E ++L+++ A + + + W++ + + +EREK + E + +
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ 894
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
E+ ++ + +E Q ES L Q + K ++++ E +KE +D ++ + Q+
Sbjct: 895 QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQD 954
Query: 222 IKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAK 281
+K K ++E ++ L+E ++L +DL L+++ + L ++K +
Sbjct: 955 MKVQK---LKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQ 1011
Query: 282 IKTFEDNLI-----------EARKEVEVSQSKYNALSLQLSNKQTEL----IQKDMDITL 326
++ + L+ E ++++ +Q +YN + +L ++ L ++K+ + +
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQ-EYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 327 VRK----ELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
+++ QEL L + +Q EL Q+++L Q+V + D E+ +
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR---QEVKEKEADFLAQEA----Q 1123
Query: 383 LYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDP 442
L EL E + E LR S L +E + A+L+ +L+ ++ L E P
Sbjct: 1124 LLEEL----EASHITEQQLRAS-------LWAQEAKAAQLQLRLRSTESQLEALAAEQQP 1172
Query: 443 DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAE 502
AQ + L+SL + LQ+ L E E + G S S+
Sbjct: 1173 GNQAQA--QAQLASLYSA----------LQQALGSVCESRPE--LSGGGDSAPSVWGL-- 1216
Query: 503 GKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKR 562
EP +RSL + + + + A K L + L Q D LRD +K
Sbjct: 1217 ----EPDQNGARSLFKRGPLLTALSAEAVASALHK---LHQDLWKTQQTRDVLRDQVQKL 1269
Query: 563 KERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
+ERL + V +L+ + + K K Q + + + +A +
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRL 1329
Query: 623 QELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKN 682
+ +Q+M + E + L+ A ++ L V E R + ++++ +
Sbjct: 1330 RRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL------RT 1383
Query: 683 GKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKEN-DFLKSLLKQQQEDTETREK 741
+ L+ ++V R ++ +++ +LK K ++EN L L +++E+ ET
Sbjct: 1384 ARSALKLKNEEVESERERAQALQEQG-ELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 742 ELEQIIKGSKDVEKENTE-LQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQ 800
+++++ K ++++K E L + + + EV + Q+ E R+ E L +++ Q
Sbjct: 1443 QIQELEK-QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 801 SADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENL 860
K T+ + + + +K+ R+ VL H + E
Sbjct: 1502 ---------------------KLTVQREQIRELEKDRETQRN--VLEHQL------LELE 1532
Query: 861 SKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIV 920
KD + + TL + +E + E Q++ + Q + + +
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME---CQQKLIKELEGQRETQRVA 1589
Query: 921 QTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQK-SSHTAVPTRVNREKYKNITAQKSSS 979
T+L + D + Q ++ ++ SH+ V R +E+ + + +Q
Sbjct: 1590 LTHLTL----------DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQ---- 1635
Query: 980 NIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK 1039
RE+I LQ+Q L T +L ++ E +L ++++ Q +RQT K
Sbjct: 1636 -----REQIEELQRQKEHL-----TQDLERRD----QELMLQKERIQVLEDQRTRQT-KI 1680
Query: 1040 LNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQY 1099
L DL ++ + ++L + ++ E + PS++ ++ ++
Sbjct: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK-----------GPSKAQRGSLEHMKL 1729
Query: 1100 KLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKI-------SRMERDITMKRHLIED 1152
L++ E+ Q ++ L+ E+ ++ +H K+ S+ E++I + + +++
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 1153 LKFRQKVNLESNKS----FSEMLQNLDKKVKTLTEECSNK-------KVSIDSLKQRLNV 1201
+ + ++ +S +S L D++++ L +E K D+L+ L
Sbjct: 1790 AREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQ 1849
Query: 1202 AVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQ 1261
A + Q KE+ + + +L + R+ E + ++ + +Q + L +Q
Sbjct: 1850 AHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQ 1909
Query: 1262 VLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHK 1321
E AQ+ + +++ +A+ KE ++ +R + + + ++ A + +
Sbjct: 1910 CAEQAQEH-EVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQE 1968
Query: 1322 AQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAEND 1359
A A + L L E + +E + A D
Sbjct: 1969 ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD 2006
Score = 97.4 bits (241), Expect = 8e-20
Identities = 229/1186 (19%), Positives = 465/1186 (39%), Gaps = 148/1186 (12%)
Query: 174 QEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKE 233
QE +QR++ L +++ V + R +LEK+ + I E V+
Sbjct: 46 QEAQQRQATLVRKLQAKVLQ----------YRSWCQELEKRLEATGGPIPQRWENVEEPN 95
Query: 234 EQNRLVIKNLEEENKKLSTRC---TDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLI 290
LV LEEE ++ + T L +EK LR++ D L+
Sbjct: 96 LDELLV--RLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELM 153
Query: 291 EARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQN-----LYKQNSTHT 345
+ ++ Q + L + L+ ++ R+ E+++ L + + H
Sbjct: 154 RKESQWQMEQEFFKGY---LKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV 210
Query: 346 AQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSV 405
L+ L + Q N + +L + T+ E +
Sbjct: 211 RLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPA------QLLLLLAKTQELEKEAHERS 264
Query: 406 TNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQK 465
L Q + E A+L++++ E A L Q+ + DY + + ET+ + +
Sbjct: 265 QELIQLKSQGDLEKAELQDRVTELS-ALLTQSQKQNEDYEKMIK-----ALRETVEILET 318
Query: 466 SEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDS 525
+ E ++ + ++ E +S + + + EG + ++ S +S
Sbjct: 319 NHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDN----------IAQGSGHENS 368
Query: 526 EELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEE 585
EL ++ ++ +KAL L R A + +++L Q +++Q QWE
Sbjct: 369 LELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWE- 427
Query: 586 GSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISI 645
E+ A+ L E L Q ++L+ E+D L +
Sbjct: 428 --------------------EEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKEREL 467
Query: 646 DKAAIQELNRC--VAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKS 703
+ A +EL + V E+ +L R + +++ + + +E E+ V E E +
Sbjct: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 704 FEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVK 763
K E +L+ L+ L+ + E +E ++ E+ EL
Sbjct: 528 LMGLEAKQSESLSELIT----LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSS 583
Query: 764 ISELETEVTSLRRQVAEANA------------------LRNENEELINPMEKSHQSADRA 805
+ L+TEV LR + +A L EN+ + + ME + Q+ +
Sbjct: 584 ENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNAL 643
Query: 806 KSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGW 865
+ ++A + R K T + + + A++ L ++ + E + K
Sbjct: 644 QVDLAEAEKRREALWEKNTHLEAQLQKAEE------AGAELQADLRDIQEEKEEIQK--- 694
Query: 866 EDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLN 925
+SES EA T+Q L + E ++ +KE+ E + E+ +
Sbjct: 695 -KLSESRHQQEAATTQ-LEQLHQEAKRQEEVLARAVQEKEALVREKA---ALEVRLQAVE 749
Query: 926 IDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNRE-KYKNITAQKS------- 977
D + + ++ K + + Q+ + T+ E + + +T K
Sbjct: 750 RDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR 809
Query: 978 SSNIILLRERIISLQQQNSV---LQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSR 1034
+ L ER + Q++++ L A++ + ++++ K +EK ++Q + ++ ++
Sbjct: 810 CLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
Query: 1035 QTIKKLNLDLAGLRKEKEDLLKKL-ESSSEITSL----AEENSQVTFPRIQVTSLSPSRS 1089
Q ++L L L +EK +L +L E +E+ ++ EE +Q Q+ +
Sbjct: 870 Q--QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER 927
Query: 1090 MDL--EMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDI-TMK 1146
+ L + Q Q +L +A+ +L + ++K K L ++E + ++ +R++
Sbjct: 928 VSLLETLLQTQKELADASQQLERLRQDMKVQK---LKEQETTGILQTQLQEAQRELKEAA 984
Query: 1147 RHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEK 1206
R +DL Q E + S + +L K+V E+ ++ V+ D ++ + V+EK
Sbjct: 985 RQHRDDLAALQ----EESSSLLQDKMDLQKQV----EDLKSQLVAQDDSQRLVEQEVQEK 1036
Query: 1207 SQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELAL--QSEQVLE 1264
+ Q Y + ++ELE++ LTL + E E + ++ A S + QEL+ Q Q +
Sbjct: 1037 LRETQEYNRIQKELEREKASLTL---SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQ 1093
Query: 1265 GAQKTL-----LLANEKVEEFTTFVKALAKELQ--NDVHVVRRQIR 1303
G QK L LL E E+ F+ A+ L+ H+ +Q+R
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
Score = 94.0 bits (232), Expect = 9e-19
Identities = 189/934 (20%), Positives = 367/934 (39%), Gaps = 166/934 (17%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ 153
+E+ T+ +LE +L L+++ + ++ + V L K+L + ++L +E
Sbjct: 1513 LEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL-----ECLALELEENHH 1567
Query: 154 KSEAKDRKVLEI------------------------LQVKDAKIQEFEQRESVLKQEIND 189
K E + + + E+ LQ + ++I + E +VL +E+ +
Sbjct: 1568 KMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE 1627
Query: 190 LVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKK 249
+ + E+ L+++ L + + + QE+ KE +Q E+Q K LEE
Sbjct: 1628 RDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE---- 1683
Query: 250 LSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQ 309
DLE+++ +E T + L++ R E SK SL+
Sbjct: 1684 ----------DLEQIKLSLRERGRE--------LTTQRQLMQERAEEGKGPSKAQRGSLE 1725
Query: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNM---DTQKVL 366
+ + L K+ ++ ++ + ELQ L Q L QQLQ L+ +T +L
Sbjct: 1726 --HMKLILRDKEKEVECQQEHIHELQELKDQ----------LEQQLQGLHRKVGETSLLL 1773
Query: 367 RNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKL 426
+E E + Q+ E E + E L+ + Q L Q++QE L+++
Sbjct: 1774 SQREQ----EIVVLQQQLQEAR---EQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQ 1826
Query: 427 QESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEK---LS 483
Q++QG + +++D A +L + K + L+E+L + + L
Sbjct: 1827 QQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE 1886
Query: 484 ENISANKGFSRKS-----------------------------IMTSAEGKHKEPPVKRSR 514
E + + SR+ + A K ++ ++ R
Sbjct: 1887 EVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR 1946
Query: 515 SLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYR 574
+ S S + + + + ALQ K Q E + + LQ +
Sbjct: 1947 AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD 2006
Query: 575 AVKEQLKQWEEGSGMTEIRKIKRADPQQLR-QEDSDAVWNELAYFKRENQELMIQKMNLE 633
A + +Q EE + E Q LR QED + LA + ++EL Q+
Sbjct: 2007 ACQAHSRQLEEALRIQE----GEIQDQDLRYQEDVQQLQQALA---QRDEELRHQQE--R 2057
Query: 634 EELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLE-QTLQ 692
E+L E + + + IQE ER EE++ + + T + +E+LE + Q
Sbjct: 2058 EQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQ 2117
Query: 693 KVTELE-----NRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQ-QQEDTETREK----- 741
+ LE ++ E++S KL +L +E + L++ L+Q + + E REK
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLA 2177
Query: 742 --------------ELEQIIKGS---KDVEKENTELQVKISELETEVTSLRRQVAEANA- 783
E+ ++ S +D E++ + +++++ E L A + A
Sbjct: 2178 LSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAE 2237
Query: 784 LRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHH 843
L + E+ + E S A+ + M R + + +++ ++ + RH+
Sbjct: 2238 LGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR----LQRHN 2293
Query: 844 TVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPT-EDGKD 902
L +++ + L + EA + G++ + + SPT +DG+
Sbjct: 2294 VQLRSTLEQVERERRKLKR-------------EAMRAAQAGSLEISKATASSPTQQDGRG 2340
Query: 903 QKESDPTEDSQTQGKEIV--QTYLNIDGKTPKDY 934
QK SD ++ Q KE+V Q L ++ K +DY
Sbjct: 2341 QKNSDAKCVAELQ-KEVVLLQAQLTLERKQKQDY 2373
Score = 90.1 bits (222), Expect = 1e-17
Identities = 209/1130 (18%), Positives = 463/1130 (40%), Gaps = 188/1130 (16%)
Query: 363 QKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQS--VTNLQDQLLQKEQENA 420
++VL Q+ + ++ S++KL N S EA RQ+ V LQ ++LQ
Sbjct: 22 EQVLALQQQMAENQAASWRKLKN----------SQEAQQRQATLVRKLQAKVLQYRSWCQ 71
Query: 421 KLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYL--------- 471
+L+++L E+ G P+P E+ + P+L L + ++ E L
Sbjct: 72 ELEKRL-EATGGPIPQRWENVEE--------PNLDELLVRLEEEQQRCESLAEVNTQLRL 122
Query: 472 -QEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSE---E 527
EK + N+ L E++ +T + ++ +++ + F E
Sbjct: 123 HMEKADVVNKALREDVEK---------LTVDWSRARDELMRKESQWQMEQEFFKGYLKGE 173
Query: 528 LQKLRKAERKIENLEKA-LQLKSQENDELRDAHEKRKERLQM----LQTNYRAVKEQLKQ 582
+L R++ + L++KS + RD E + E +++ L R +
Sbjct: 174 HGRLLSLWREVVTFRRHFLEMKSATD---RDLMELKAEHVRLSGSLLTCCLRLTVGAQSR 230
Query: 583 WEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVH 642
GSG + R +P QL + QEL + +EL +LK
Sbjct: 231 EPNGSGRMDGR-----EPAQL------------LLLLAKTQELEKEAHERSQELIQLKSQ 273
Query: 643 ISIDKAAIQ----ELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELE 698
++KA +Q EL+ + + +++ +D K + E+LE ++ E E
Sbjct: 274 GDLEKAELQDRVTELSALLTQSQKQN------EDYEKMIKALRETVEILETNHTELMEHE 327
Query: 699 ---NRLKSFEKRSRK--LKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGS--- 750
+R EK S + +K+ + +++E D + Q EL+ I
Sbjct: 328 ASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA------QGSGHENSLELDSSIFSQFDY 381
Query: 751 KDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSH-QSADRAKSEM 809
+D +K T ++ ++ V LR+Q+A +E +N +++ H Q + K+
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGC-------QEAVNLLQQQHDQWEEEGKALR 434
Query: 810 ATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWE--- 866
++ +G D T+ + S+ + +L + + + E L ++ W
Sbjct: 435 QRLQKLTGERD---TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRR 491
Query: 867 -----DVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQ 921
+ S+ + + Q + V +++ G + K+S+ + T + +
Sbjct: 492 VNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALES 551
Query: 922 TYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNI 981
++L +G+ + + A ++ ++ S +T + T V + + + +
Sbjct: 552 SHL--EGELLRQEQTEVTAALARAEQSIAELSSSENT-LKTEVADLRAAAVKLSALNEAL 608
Query: 982 IL----LRERIISLQQQNSVL-------QNAKKTAELSVKEYKEVNEKLLHQQQVSDQRF 1030
L L ++++ L+++N + + A+ ++ + E ++ E L + + +
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
Query: 1031 QTSRQTIKKLNLDLAGLRKEKEDLLKKLESS-----------SEITSLAEENSQVTFPRI 1079
Q + + +L DL +++EKE++ KKL S ++ A+ +V +
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAV 728
Query: 1080 QVTS--LSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKIS 1137
Q + ++++ ++ ++ ++ +L SS + L+ L ++ +
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
Query: 1138 RME---RDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDS 1194
++E + +T + +I+ K+ L++ +S +E Q D + L + K +++
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE--QERDAAARQLAQAEQEGKTALEQ 846
Query: 1195 LKQRLNVAV--------KEKSQYEQMYQKSKEELEKKDLKLTL-LVSRISETESAMAEIE 1245
K V KE+S ++Q K+ E LE++ ++L + L + +E E+ A+ E
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE 906
Query: 1246 ---TAASKQLQELALQSE-------QVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDV 1295
T A L ++ L++E + L QK L A++++E +K + Q
Sbjct: 907 EERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETT 966
Query: 1296 HVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKID 1355
+++ Q++E ++ K + + + A++ S S L++ +D + QVE K+++
Sbjct: 967 GILQTQLQEAQR------ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
Query: 1356 AENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKLVEGYFTIMKDI 1405
A++D Q+L+E +++ EK + + Y I K++
Sbjct: 1021 AQDDS------QRLVE--------------QEVQEKLRETQEYNRIQKEL 1050
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 134 bits (336), Expect = 8e-31
Identities = 231/1178 (19%), Positives = 482/1178 (40%), Gaps = 158/1178 (13%)
Query: 149 EREKQKSEAKD--RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ +K+ + L +AK +E E++ L +E NDL + A E A +
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
L K +IK+ E +++EE N L + +KL C++L D++ L
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDLEL 965
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
A + KEK++T+ K+K + + A + +++ +LQ +++QT +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEM--AGLDETIAKLTKEKKALQEAHQQT--------LDD 1015
Query: 327 VRKELQELQNLYKQNSTHTAQQAEL---IQQLQVLNMDTQKVLRNQEDVHTAESISYQKL 383
++ E ++ L K Q +L ++Q + L MD ++ R E S +
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDI 1075
Query: 384 YNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPD 443
NE E K E ++NLQ ++ ++ +L++K++E Q L +E + +
Sbjct: 1076 ENEKQQLDEKLKKKEF----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 444 YSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEG 503
R S + E E+E + E+L+ A S I NK R++
Sbjct: 1132 -------RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRR 1182
Query: 504 KHKEPPVKRSRSLSP-KSSFTDS-----EELQKLRKAERKIENLEKALQLKSQENDELRD 557
+E ++ + + + DS E++ L++ ++K+E + ++++ + +
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 558 AHEKRKERLQMLQTNYRAVKEQLKQWEEG-----SGMTEIR-KIKRADPQQLRQ-EDSDA 610
K K L+ + +LK EE + +T R +++ + RQ ++ +A
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 611 VWNELAYFKRE-NQELMIQKMNLEEEL-----------------DELKVHISIDKAAIQE 652
+ ++L+ K+ Q++ K LEEE+ D L+ ++ + E
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362
Query: 653 LNRCVAERREE--QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTE----LENRLKSFEK 706
L R +++ E Q E D ++R+ + K+ L Q LQ E + + S EK
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 707 RSRKLKEGNKKLM---------------KENDFLKSLLKQQQEDTETREKELEQIIKGSK 751
++L+ + LM K+ +F K L + +Q+ ET ELE K ++
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET-HAELEASQKEAR 1481
Query: 752 DVEKE----NTELQVKISELET---EVTSLRRQVAEANALRNENEELINPMEKSHQSADR 804
+ E + + +LET E +L++++++ E + I+ +EK + ++
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Query: 805 AKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDG 864
K E+ ++ + + ++ + K + + + + ++ I + L ++
Sbjct: 1542 EKCEL-----QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH 1596
Query: 865 WEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYL 924
V S +A+ I ++ +G + + E ++ Y
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAI------RLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1650
Query: 925 NIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILL 984
N G H +A + +++ K Q + V R N LL
Sbjct: 1651 NTQGILKDTQIHLDDALR---SQEDLKEQLA---MVERRAN-----------------LL 1687
Query: 985 RERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDL 1044
+ I L+ + ++K AE + + E +LLH Q S T KKL D+
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASE-RVQLLHTQNTS------LINTKKKLETDI 1740
Query: 1045 AGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNA 1104
+ ++ E ED+L++ ++ E + +T + L + +++++ ++
Sbjct: 1741 SQMQGEMEDILQEARNAEE-----KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 1105 TNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESN 1164
+L + + L +K ++I ++E + R L +++ QK N E+
Sbjct: 1796 VKDLQLRLDEAEQLA---------LKGGKKQIQKLEARV---RELEGEVESEQKRNAEAV 1843
Query: 1165 KSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKD 1224
K L+ +++VK LT + + +I L+ ++ + Y++ ++++E+
Sbjct: 1844 KG----LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 1225 LKLTLLVSRISETESAMAEIETAASKQLQELALQSEQV 1262
K L + E E E A Q+ +L ++S +V
Sbjct: 1900 AKFRKLQHELEEAE----ERADIAESQVNKLRVKSREV 1933
Score = 132 bits (332), Expect = 2e-30
Identities = 232/1224 (18%), Positives = 505/1224 (41%), Gaps = 200/1224 (16%)
Query: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVV 148
L+ E+ M T ++EE +K+ELA +A ++ + L DL V
Sbjct: 846 LKSAETEKEMAT----MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA 901
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN-DLVKRKIAVDEENAFLRKE 207
E E D+ + +Q+ +AKI+E +R ++EIN +L +K +++E + L+K+
Sbjct: 902 EGLADAEERCDQLIKTKIQL-EAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKD 959
Query: 208 FSDL--------------EKKFKDKSQEIKDTKECV-------QNKEEQNRLVIKNLEEE 246
DL E K K+ ++E+ E + + +E ++ + +L+ E
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 247 NKKLST----------RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEV 296
K++T + DL LE+ +K L + K + +K ++++++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ----NLYKQNSTHTAQQAELI 352
+ K ++SN Q+++ + ++K+++ELQ L ++ A +A+
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 353 QQLQVLNMDTQKVLRNQEDVHTAES----------ISYQKLYNELHICFETTKSNEAMLR 402
+Q L+ + +++ E+ A S +QK+ +L ++ A LR
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 403 QSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMV 462
+ + +L ++ ++K+KL++ + + E D S + +LE +
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 463 SQKSEIEYLQEKLKIANEKLSENISANKG-FSRKSIMTSAEGKHKEPPVKRSRSLSPKSS 521
+ + ++ L+ K + ++L +++A +G +S S + KE V S+ K +
Sbjct: 1257 TLEDQLSELKSK-EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV--SQLSRGKQA 1313
Query: 522 FTDS-EELQKLRKAERKIEN-LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQ 579
FT EEL++ + E K +N L ALQ + D LR+ +E+ +E LQ +
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 580 LKQWE--------EGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMN 631
+ QW + + E K K A Q +E +AV + A ++ K
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK-------TKQR 1426
Query: 632 LEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTL 691
L+ E+++L + + AA L++ ++N ++L +
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDK-----------------------KQRNFDKILAEWK 1463
Query: 692 QKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSK 751
QK E L++ +K +R L G + +N + E+ L+Q+ +
Sbjct: 1464 QKCEETHAELEASQKEARSL--GTELFKIKNAY---------------EESLDQL----E 1502
Query: 752 DVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMAT 811
+++EN LQ +IS+L ++ +++ E ++ + E+ ++ + + A+ A E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE-ASLEHEE 1561
Query: 812 MKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSES 871
K+ + + ++V K A+K+ + + + + I+++ ++ +S
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQ---LKRNHIRIVESM-------------QS 1605
Query: 872 SSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTP 931
+ D+E ++ + ++ +G + + E ++ Y N G
Sbjct: 1606 TLDAEIRSR--------NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 932 KDYFH---------DKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNII 982
H D + +++ +Q T E+ + I Q+ ++
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE----LL 1713
Query: 983 LLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNL 1042
ER+ L QN+ L N KK E + + + E +L Q + + + KK
Sbjct: 1714 DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDIL-------QEARNAEEKAKKAIT 1766
Query: 1043 DLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLK 1102
D A + +E LKK + +S ++N + T +Q+ R + E Q LK
Sbjct: 1767 DAAMMAEE----LKKEQDTSAHLERMKKNMEQTVKDLQL------RLDEAE----QLALK 1812
Query: 1103 NATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLE 1162
++ K + V+ L+ E+ ++++ E + + + ER +++L ++ + + +
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER-------RVKELTYQTEEDRK 1865
Query: 1163 SNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEK 1222
+ +++ L KVK S K++ A ++ + ++K + ELE+
Sbjct: 1866 NILRLQDLVDKLQAKVK--------------SYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Query: 1223 KDLKLTLLVSRISETESAMAEIET 1246
+ + + S++++ E+ T
Sbjct: 1912 AEERADIAESQVNKLRVKSREVHT 1935
Score = 103 bits (257), Expect = 1e-21
Identities = 205/960 (21%), Positives = 392/960 (40%), Gaps = 145/960 (15%)
Query: 492 FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKA---LQLK 548
F K ++ SAE + KE + K SE K ++ E K+ L K LQL+
Sbjct: 840 FKIKPLLKSAETE-KEMATMKEEFQKIKDELAKSEA--KRKELEEKMVTLLKEKNDLQLQ 896
Query: 549 SQ-ENDELRDAHEKRKERLQ---MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
Q E + L DA E+ + ++ L+ + V E+ + EE + +K K D
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEE---LDELKVHISIDKAAIQELNRCVAERR 661
++D D + LA ++E + NL EE LDE ++ +K A+QE ++ +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ E+D+V T K E Q+V +LE L+ +K L+ +KL E
Sbjct: 1017 Q------AEEDKVNTLTKAKIKLE------QQVDDLEGSLEQEKKLRMDLERAKRKL--E 1062
Query: 722 NDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEA 781
D LK QE E E +Q+ + K E E + LQ KI + + L++++ E
Sbjct: 1063 GD-----LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL 1117
Query: 782 NALRNENEELINPMEKSHQSADRAKSEMAT-MKVRSGRYDCKTTMTKVKFKAAKKNCSVG 840
A E EE I S A++ +S+++ ++ S R + T + + KK
Sbjct: 1118 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---- 1173
Query: 841 RHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTL----GTIIVETSQKISP 896
F+ + +D + E++ EA T+ TL + E ++I
Sbjct: 1174 -------------EAEFQKMRRD----LEEATLQHEA-TAATLRKKHADSVAELGEQIDN 1215
Query: 897 TEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSS 956
+ K + E + +E EI N++ + +K + Q K ++
Sbjct: 1216 LQRVKQKLEKEKSEMKM----EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 957 HTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVN 1016
+ + ++ + T S + +E ++S L K+ ++E K
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ------LSRGKQAFTQQIEELKRQL 1325
Query: 1017 EKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEIT-SLAEENSQVT 1075
E+ + + Q+SR D LR++ E+ + ES +E+ +L++ N++V
Sbjct: 1326 EEEIKAKNALAHALQSSRH-------DCDLLREQYEE---EQESKAELQRALSKANTEVA 1375
Query: 1076 FPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEK 1135
R + + + R+ +LE + K L L A EEH++ ++ K
Sbjct: 1376 QWRTKYETDAIQRTEELEEAK-------------------KKLAQRLQAAEEHVEAVNAK 1416
Query: 1136 ISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSL 1195
+ +E+ ++ +EDL + + + + +N DK + ++C +++
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 1196 KQRLNVAVKEKSQYEQMYQKSKEEL-----EKKDL--KLTLLVSRISETESAMAEIETAA 1248
++ E + + Y++S ++L E K+L +++ L +I+E + E+E
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KI 1535
Query: 1249 SKQLQELALQSEQVLEGAQKTL-----------LLAN-----------EKVEEF------ 1280
KQ+++ + + LE A+ +L L N EK EE
Sbjct: 1536 KKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1595
Query: 1281 -TTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEE 1339
V+++ L ++ IR KKM+ + + + + A +AA L R+
Sbjct: 1596 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI 1655
Query: 1340 ILDTEDQVEIEKTKIDAENDKEWMLYIQK---LLEGQLPFASYLLEAVLEKINEKKKLVE 1396
+ DT Q+ ++ E+ KE + +++ LL+ ++ L A LE+ +K+ E
Sbjct: 1656 LKDT--QIHLDDALRSQEDLKEQLAMVERRANLLQAEIE----ELRATLEQTERSRKIAE 1709
Score = 99.8 bits (247), Expect = 2e-20
Identities = 198/1138 (17%), Positives = 480/1138 (42%), Gaps = 134/1138 (11%)
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQ 319
++ ++++ ++ E ++AK K E+ ++ KE N L LQ+ + L
Sbjct: 854 EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-------NDLQLQVQAEAEGLAD 906
Query: 320 KDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESIS 379
+ + K +L+ K+ + + E+ N + R ED E
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEI-------NAELTAKKRKLED----ECSE 955
Query: 380 YQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKL---KEKLQESQGAPLPL 436
+K ++L + + + V NL +++ ++ AKL K+ LQE+
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH------ 1009
Query: 437 PQESDPDYSAQVPHRPSLSSLETLMVSQKSEIE---YLQEKLKIANEKLSENISANKGFS 493
Q++ D A+ +L+ + + Q ++E ++KL++ E+ + + +
Sbjct: 1010 -QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 494 RKSIMTSAEGKHK--EPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQE 551
++SIM K + E K+ +S S + E+ ++ ++KI+ L+ ++ +E
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ-LQKKIKELQARIEELEEE 1127
Query: 552 NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMT----EIRKIKRADPQQLRQED 607
+ R + K +++ L + E+L EE G T E+ K + A+ Q++R++
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRDL 1184
Query: 608 SDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFR 667
+A A ++ L E++D L+ Q+L + +E + E
Sbjct: 1185 EEATLQHEATAATLRKKHADSVAELGEQIDNLQ-------RVKQKLEKEKSEMKMEI--- 1234
Query: 668 SGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKS 727
DD K LE+ + + + + LKS E+ ++L L + L++
Sbjct: 1235 ---DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND---LTAQRGRLQT 1288
Query: 728 LLKQQQEDTETREKELEQIIKG----SKDVEKENTELQVKISELETEVTSLRRQVAEANA 783
+ + +E + Q+ +G ++ +E+ +L+ +I +L+ + +
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 784 LRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTT--MTKVKFKAAKKNCSVGR 841
LR + EE + ++ +A +E+A + + + T + + K K A++ +
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 842 HHTVLNH---SIKVMSNVFENLSKDGWEDVSESSSDSEA--QTSQTLGTIIVETSQKISP 896
H +N S++ +N +D DV +++ A + + I+ E QK
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1468
Query: 897 TEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSS 956
T + + +++++ G E+ + K+ + + + T +++N +Q
Sbjct: 1469 THAELEASQ----KEARSLGTELFKI---------KNAYEESLDQLETLKRENKNLQ--- 1512
Query: 957 HTAVPTRVNREKYKNITAQ--KSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKE 1014
++ ++T Q + I L + ++Q+ LQ A + AE S++ E
Sbjct: 1513 ----------QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH--E 1560
Query: 1015 VNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQV 1074
+ L Q +++ + + R+ +K + ++ L++ +++ ++S+ + AE S+
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEK-DEEIDQLKRNHIRIVESMQSTLD----AEIRSRN 1615
Query: 1075 TFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHI----- 1129
R++ + M+ ++ +++ +L +A + N + + L + H+
Sbjct: 1616 DAIRLK-------KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 1130 --KEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSN 1187
+++ E+++ +ER + + IE+L+ + S K + L + ++V+ L
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL----HT 1724
Query: 1188 KKVSIDSLKQRLNVAVKE-KSQYEQMYQKSKEELEKKDLKLT---LLVSRISETESAMAE 1243
+ S+ + K++L + + + + E + Q+++ EK +T ++ + + + A
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 1244 IETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIR 1303
+E Q + ++ E Q L +++++ V+ L E++++ +R
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE---QKRNAE 1841
Query: 1304 ELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKE 1361
+K ++K+ K T++ + +IL L++++D + Q +++ K AE +E
Sbjct: 1842 AVKGLRKHERRVKELTYQTEEDRKNILR-----LQDLVD-KLQAKVKSYKRQAEEAEE 1893
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 134 bits (336), Expect = 8e-31
Identities = 231/1178 (19%), Positives = 482/1178 (40%), Gaps = 158/1178 (13%)
Query: 149 EREKQKSEAKD--RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ +K+ + L +AK +E E++ L +E NDL + A E A +
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 207 EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRK 266
L K +IK+ E +++EE N L + +KL C++L D++ L
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDLEL 965
Query: 267 QEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITL 326
A + KEK++T+ K+K + + A + +++ +LQ +++QT +
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEM--AGLDETIAKLTKEKKALQEAHQQT--------LDD 1015
Query: 327 VRKELQELQNLYKQNSTHTAQQAEL---IQQLQVLNMDTQKVLRNQEDVHTAESISYQKL 383
++ E ++ L K Q +L ++Q + L MD ++ R E S +
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDI 1075
Query: 384 YNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPD 443
NE E K E ++NLQ ++ ++ +L++K++E Q L +E + +
Sbjct: 1076 ENEKQQLDEKLKKKEF----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 444 YSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEG 503
R S + E E+E + E+L+ A S I NK R++
Sbjct: 1132 -------RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK--KREAEFQKMRR 1182
Query: 504 KHKEPPVKRSRSLSP-KSSFTDS-----EELQKLRKAERKIENLEKALQLKSQENDELRD 557
+E ++ + + + DS E++ L++ ++K+E + ++++ + +
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 558 AHEKRKERLQMLQTNYRAVKEQLKQWEEG-----SGMTEIR-KIKRADPQQLRQ-EDSDA 610
K K L+ + +LK EE + +T R +++ + RQ ++ +A
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 611 VWNELAYFKRE-NQELMIQKMNLEEEL-----------------DELKVHISIDKAAIQE 652
+ ++L+ K+ Q++ K LEEE+ D L+ ++ + E
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362
Query: 653 LNRCVAERREE--QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTE----LENRLKSFEK 706
L R +++ E Q E D ++R+ + K+ L Q LQ E + + S EK
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 707 RSRKLKEGNKKLM---------------KENDFLKSLLKQQQEDTETREKELEQIIKGSK 751
++L+ + LM K+ +F K L + +Q+ ET ELE K ++
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET-HAELEASQKEAR 1481
Query: 752 DVEKE----NTELQVKISELET---EVTSLRRQVAEANALRNENEELINPMEKSHQSADR 804
+ E + + +LET E +L++++++ E + I+ +EK + ++
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Query: 805 AKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDG 864
K E+ ++ + + ++ + K + + + + ++ I + L ++
Sbjct: 1542 EKCEL-----QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH 1596
Query: 865 WEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYL 924
V S +A+ I ++ +G + + E ++ Y
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAI------RLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1650
Query: 925 NIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILL 984
N G H +A + +++ K Q + V R N LL
Sbjct: 1651 NTQGILKDTQIHLDDALR---SQEDLKEQLA---MVERRAN-----------------LL 1687
Query: 985 RERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDL 1044
+ I L+ + ++K AE + + E +LLH Q S T KKL D+
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASE-RVQLLHTQNTS------LINTKKKLETDI 1740
Query: 1045 AGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNA 1104
+ ++ E ED+L++ ++ E + +T + L + +++++ ++
Sbjct: 1741 SQMQGEMEDILQEARNAEE-----KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1795
Query: 1105 TNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESN 1164
+L + + L +K ++I ++E + R L +++ QK N E+
Sbjct: 1796 VKDLQLRLDEAEQLA---------LKGGKKQIQKLEARV---RELEGEVESEQKRNAEAV 1843
Query: 1165 KSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKD 1224
K L+ +++VK LT + + +I L+ ++ + Y++ ++++E+
Sbjct: 1844 KG----LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 1225 LKLTLLVSRISETESAMAEIETAASKQLQELALQSEQV 1262
K L + E E E A Q+ +L ++S +V
Sbjct: 1900 AKFRKLQHELEEAE----ERADIAESQVNKLRVKSREV 1933
Score = 132 bits (332), Expect = 2e-30
Identities = 232/1224 (18%), Positives = 505/1224 (41%), Gaps = 200/1224 (16%)
Query: 89 LEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVV 148
L+ E+ M T ++EE +K+ELA +A ++ + L DL V
Sbjct: 846 LKSAETEKEMAT----MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA 901
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEIN-DLVKRKIAVDEENAFLRKE 207
E E D+ + +Q+ +AKI+E +R ++EIN +L +K +++E + L+K+
Sbjct: 902 EGLADAEERCDQLIKTKIQL-EAKIKEVTERAED-EEEINAELTAKKRKLEDECSELKKD 959
Query: 208 FSDL--------------EKKFKDKSQEIKDTKECV-------QNKEEQNRLVIKNLEEE 246
DL E K K+ ++E+ E + + +E ++ + +L+ E
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 247 NKKLST----------RCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEV 296
K++T + DL LE+ +K L + K + +K ++++++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 297 EVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ----NLYKQNSTHTAQQAELI 352
+ K ++SN Q+++ + ++K+++ELQ L ++ A +A+
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 353 QQLQVLNMDTQKVLRNQEDVHTAES----------ISYQKLYNELHICFETTKSNEAMLR 402
+Q L+ + +++ E+ A S +QK+ +L ++ A LR
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 403 QSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMV 462
+ + +L ++ ++K+KL++ + + E D S + +LE +
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 463 SQKSEIEYLQEKLKIANEKLSENISANKG-FSRKSIMTSAEGKHKEPPVKRSRSLSPKSS 521
+ + ++ L+ K + ++L +++A +G +S S + KE V S+ K +
Sbjct: 1257 TLEDQLSELKSK-EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV--SQLSRGKQA 1313
Query: 522 FTDS-EELQKLRKAERKIEN-LEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQ 579
FT EEL++ + E K +N L ALQ + D LR+ +E+ +E LQ +
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 580 LKQWE--------EGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMN 631
+ QW + + E K K A Q +E +AV + A ++ K
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK-------TKQR 1426
Query: 632 LEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTL 691
L+ E+++L + + AA L++ ++N ++L +
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDK-----------------------KQRNFDKILAEWK 1463
Query: 692 QKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSK 751
QK E L++ +K +R L G + +N + E+ L+Q+ +
Sbjct: 1464 QKCEETHAELEASQKEARSL--GTELFKIKNAY---------------EESLDQL----E 1502
Query: 752 DVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMAT 811
+++EN LQ +IS+L ++ +++ E ++ + E+ ++ + + A+ A E
Sbjct: 1503 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE-ASLEHEE 1561
Query: 812 MKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSES 871
K+ + + ++V K A+K+ + + + + I+++ ++ +S
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQ---LKRNHIRIVESM-------------QS 1605
Query: 872 SSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTP 931
+ D+E ++ + ++ +G + + E ++ Y N G
Sbjct: 1606 TLDAEIRSR--------NDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 932 KDYFH---------DKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNII 982
H D + +++ +Q T E+ + I Q+ ++
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE----LL 1713
Query: 983 LLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNL 1042
ER+ L QN+ L N KK E + + + E +L Q + + + KK
Sbjct: 1714 DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDIL-------QEARNAEEKAKKAIT 1766
Query: 1043 DLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLK 1102
D A + +E LKK + +S ++N + T +Q+ R + E Q LK
Sbjct: 1767 DAAMMAEE----LKKEQDTSAHLERMKKNMEQTVKDLQL------RLDEAE----QLALK 1812
Query: 1103 NATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLE 1162
++ K + V+ L+ E+ ++++ E + + + ER +++L ++ + + +
Sbjct: 1813 GGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER-------RVKELTYQTEEDRK 1865
Query: 1163 SNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEK 1222
+ +++ L KVK S K++ A ++ + ++K + ELE+
Sbjct: 1866 NILRLQDLVDKLQAKVK--------------SYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Query: 1223 KDLKLTLLVSRISETESAMAEIET 1246
+ + + S++++ E+ T
Sbjct: 1912 AEERADIAESQVNKLRVKSREVHT 1935
Score = 103 bits (257), Expect = 1e-21
Identities = 205/960 (21%), Positives = 392/960 (40%), Gaps = 145/960 (15%)
Query: 492 FSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKA---LQLK 548
F K ++ SAE + KE + K SE K ++ E K+ L K LQL+
Sbjct: 840 FKIKPLLKSAETE-KEMATMKEEFQKIKDELAKSEA--KRKELEEKMVTLLKEKNDLQLQ 896
Query: 549 SQ-ENDELRDAHEKRKERLQ---MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR 604
Q E + L DA E+ + ++ L+ + V E+ + EE + +K K D
Sbjct: 897 VQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 956
Query: 605 QEDSDAVWNELAYFKRENQELMIQKMNLEEE---LDELKVHISIDKAAIQELNRCVAERR 661
++D D + LA ++E + NL EE LDE ++ +K A+QE ++ +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ E+D+V T K E Q+V +LE L+ +K L+ +KL E
Sbjct: 1017 Q------AEEDKVNTLTKAKIKLE------QQVDDLEGSLEQEKKLRMDLERAKRKL--E 1062
Query: 722 NDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEA 781
D LK QE E E +Q+ + K E E + LQ KI + + L++++ E
Sbjct: 1063 GD-----LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL 1117
Query: 782 NALRNENEELINPMEKSHQSADRAKSEMAT-MKVRSGRYDCKTTMTKVKFKAAKKNCSVG 840
A E EE I S A++ +S+++ ++ S R + T + + KK
Sbjct: 1118 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR---- 1173
Query: 841 RHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTL----GTIIVETSQKISP 896
F+ + +D + E++ EA T+ TL + E ++I
Sbjct: 1174 -------------EAEFQKMRRD----LEEATLQHEA-TAATLRKKHADSVAELGEQIDN 1215
Query: 897 TEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSS 956
+ K + E + +E EI N++ + +K + Q K ++
Sbjct: 1216 LQRVKQKLEKEKSEMKM----EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 957 HTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVN 1016
+ + ++ + T S + +E ++S L K+ ++E K
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ------LSRGKQAFTQQIEELKRQL 1325
Query: 1017 EKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEIT-SLAEENSQVT 1075
E+ + + Q+SR D LR++ E+ + ES +E+ +L++ N++V
Sbjct: 1326 EEEIKAKNALAHALQSSRH-------DCDLLREQYEE---EQESKAELQRALSKANTEVA 1375
Query: 1076 FPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEK 1135
R + + + R+ +LE + K L L A EEH++ ++ K
Sbjct: 1376 QWRTKYETDAIQRTEELEEAK-------------------KKLAQRLQAAEEHVEAVNAK 1416
Query: 1136 ISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSL 1195
+ +E+ ++ +EDL + + + + +N DK + ++C +++
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 1196 KQRLNVAVKEKSQYEQMYQKSKEEL-----EKKDL--KLTLLVSRISETESAMAEIETAA 1248
++ E + + Y++S ++L E K+L +++ L +I+E + E+E
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KI 1535
Query: 1249 SKQLQELALQSEQVLEGAQKTL-----------LLAN-----------EKVEEF------ 1280
KQ+++ + + LE A+ +L L N EK EE
Sbjct: 1536 KKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1595
Query: 1281 -TTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEE 1339
V+++ L ++ IR KKM+ + + + + A +AA L R+
Sbjct: 1596 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI 1655
Query: 1340 ILDTEDQVEIEKTKIDAENDKEWMLYIQK---LLEGQLPFASYLLEAVLEKINEKKKLVE 1396
+ DT Q+ ++ E+ KE + +++ LL+ ++ L A LE+ +K+ E
Sbjct: 1656 LKDT--QIHLDDALRSQEDLKEQLAMVERRANLLQAEIE----ELRATLEQTERSRKIAE 1709
Score = 99.8 bits (247), Expect = 2e-20
Identities = 198/1138 (17%), Positives = 480/1138 (42%), Gaps = 134/1138 (11%)
Query: 260 DLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQ 319
++ ++++ ++ E ++AK K E+ ++ KE N L LQ+ + L
Sbjct: 854 EMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-------NDLQLQVQAEAEGLAD 906
Query: 320 KDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESIS 379
+ + K +L+ K+ + + E+ N + R ED E
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEI-------NAELTAKKRKLED----ECSE 955
Query: 380 YQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKL---KEKLQESQGAPLPL 436
+K ++L + + + V NL +++ ++ AKL K+ LQE+
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH------ 1009
Query: 437 PQESDPDYSAQVPHRPSLSSLETLMVSQKSEIE---YLQEKLKIANEKLSENISANKGFS 493
Q++ D A+ +L+ + + Q ++E ++KL++ E+ + + +
Sbjct: 1010 -QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1068
Query: 494 RKSIMTSAEGKHK--EPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQE 551
++SIM K + E K+ +S S + E+ ++ ++KI+ L+ ++ +E
Sbjct: 1069 QESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQ-LQKKIKELQARIEELEEE 1127
Query: 552 NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMT----EIRKIKRADPQQLRQED 607
+ R + K +++ L + E+L EE G T E+ K + A+ Q++R++
Sbjct: 1128 IEAERASRAKAEKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRDL 1184
Query: 608 SDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFR 667
+A A ++ L E++D L+ Q+L + +E + E
Sbjct: 1185 EEATLQHEATAATLRKKHADSVAELGEQIDNLQ-------RVKQKLEKEKSEMKMEI--- 1234
Query: 668 SGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKS 727
DD K LE+ + + + + LKS E+ ++L L + L++
Sbjct: 1235 ---DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND---LTAQRGRLQT 1288
Query: 728 LLKQQQEDTETREKELEQIIKG----SKDVEKENTELQVKISELETEVTSLRRQVAEANA 783
+ + +E + Q+ +G ++ +E+ +L+ +I +L+ + +
Sbjct: 1289 ESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL 1348
Query: 784 LRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTT--MTKVKFKAAKKNCSVGR 841
LR + EE + ++ +A +E+A + + + T + + K K A++ +
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE 1408
Query: 842 HHTVLNH---SIKVMSNVFENLSKDGWEDVSESSSDSEA--QTSQTLGTIIVETSQKISP 896
H +N S++ +N +D DV +++ A + + I+ E QK
Sbjct: 1409 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEE 1468
Query: 897 TEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSS 956
T + + +++++ G E+ + K+ + + + T +++N +Q
Sbjct: 1469 THAELEASQ----KEARSLGTELFKI---------KNAYEESLDQLETLKRENKNLQ--- 1512
Query: 957 HTAVPTRVNREKYKNITAQ--KSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKE 1014
++ ++T Q + I L + ++Q+ LQ A + AE S++ E
Sbjct: 1513 ----------QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH--E 1560
Query: 1015 VNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQV 1074
+ L Q +++ + + R+ +K + ++ L++ +++ ++S+ + AE S+
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEK-DEEIDQLKRNHIRIVESMQSTLD----AEIRSRN 1615
Query: 1075 TFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHI----- 1129
R++ + M+ ++ +++ +L +A + N + + L + H+
Sbjct: 1616 DAIRLK-------KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 1130 --KEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSN 1187
+++ E+++ +ER + + IE+L+ + S K + L + ++V+ L
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL----HT 1724
Query: 1188 KKVSIDSLKQRLNVAVKE-KSQYEQMYQKSKEELEKKDLKLT---LLVSRISETESAMAE 1243
+ S+ + K++L + + + + E + Q+++ EK +T ++ + + + A
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 1244 IETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIR 1303
+E Q + ++ E Q L +++++ V+ L E++++ +R
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESE---QKRNAE 1841
Query: 1304 ELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKE 1361
+K ++K+ K T++ + +IL L++++D + Q +++ K AE +E
Sbjct: 1842 AVKGLRKHERRVKELTYQTEEDRKNILR-----LQDLVD-KLQAKVKSYKRQAEEAEE 1893
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 133 bits (334), Expect = 1e-30
Identities = 240/1175 (20%), Positives = 483/1175 (41%), Gaps = 130/1175 (11%)
Query: 149 EREKQKSEAKD--RKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRK 206
E EK+ + K+ +K + L +AK +E E++ L QE NDL + ++ + EN +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDL-QLQVQAESENLLDAE 903
Query: 207 EFSD--LEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKL 264
E D ++ KF+ ++ +IK+ E +++EE N L + +KL C++L D++ L
Sbjct: 904 ERCDQLIKAKFQLEA-KIKEVTERAEDEEEIN----AELTAKKRKLEDECSELKKDIDDL 958
Query: 265 RKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDI 324
A + KEK++T+ K+K + L + + +++ +LQ +++Q
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEEL--SGLDETIAKLTREKKALQEAHQQA--------- 1007
Query: 325 TLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLY 384
L +LQ + ++ +++L QQ++ D + L ++ + + +KL
Sbjct: 1008 ------LDDLQAEEDKVNSLNKTKSKLEQQVE----DLESSLEQEKKLRVDLERNKRKLE 1057
Query: 385 NELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDY 444
+L + E+ L L ++L +K+ E +L+ K+++ Q L Q+ +
Sbjct: 1058 GDLKLAQESILD----LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQF-QKKIKEL 1112
Query: 445 SAQV--------PHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKS 496
A++ R + + E E+E L E+L+ A S I NK +
Sbjct: 1113 QARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEF 1172
Query: 497 I-----MTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQE 551
+ + A +H E V R S E++ L++ ++K+E + +L E
Sbjct: 1173 LKLRRDLEEATLQH-EAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL---E 1228
Query: 552 NDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAV 611
D+L + E + L+ R +++QL E G E
Sbjct: 1229 IDDLSSSMESVSKSKANLEKICRTLEDQL---SEARGKNE-------------------- 1265
Query: 612 WNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGED 671
+R EL QK L+ E EL + ++ + +L+ R +Q F + +
Sbjct: 1266 -----EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS------RSKQAF-TQQT 1313
Query: 672 DEVKRSTPEKN-GKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLK 730
+E+KR E+N K L LQ + L+ ++ + +EG +L ++L K
Sbjct: 1314 EELKRQLEEENKAKNALAHALQSSRHDCDLLR---EQYEEEQEGKAELQ------RALSK 1364
Query: 731 QQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEE 790
E + R K I+ ++++E+ +L ++ + E +V ++ A+ +L +
Sbjct: 1365 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVN---AKCASLEKTKQR 1421
Query: 791 LINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVG-RHHTVLNHS 849
L +E +RA S A + + +D K K + ++ + L+
Sbjct: 1422 LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE 1481
Query: 850 IKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPT 909
+ + N +E + D E V + + E + + L I E + I E + Q E +
Sbjct: 1482 LFKLKNAYEE-ALDQLETVKRENKNLEQEIAD-LTEQIAENGKTIHELEKSRKQIELEKA 1539
Query: 910 EDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQK---KNCKMQKSSHTAVPTRVNR 966
D Q +E + + K + K +K K+ ++++ T
Sbjct: 1540 -DIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETM 1598
Query: 967 EKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVS 1026
+ + + + I L ++ L + L +A + A ++K + V +L Q
Sbjct: 1599 QSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHL 1658
Query: 1027 DQRFQTSRQTIKKLNL---DLAGLRKEKEDLLKKLESSSEITSLAEE-----NSQVTFPR 1078
D + ++L + L+ E E+L LE + LAE+ N +V
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718
Query: 1079 IQVTSL-SPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKIS 1137
Q TSL + ++ ++ QLQ ++++A+ + K + E +K+ + +
Sbjct: 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSA 1778
Query: 1138 RMERDITMKRHL---IEDLKFR-QKVNLESNKSFSEMLQNLDKKVKTLTEEC-SNKKVSI 1192
+ER MK++L ++DL+ R + + K + +Q L+ +++ L E +K +
Sbjct: 1779 HLER---MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Query: 1193 DSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDL--KLTLLV---SRISETESAMAEIETA 1247
+S+K + K Q + K L +DL KL + V R +E A
Sbjct: 1836 ESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLT 1895
Query: 1248 ASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTT 1282
++ Q ++E+ + A+ + K +FT+
Sbjct: 1896 KFRKAQHELEEAEERADIAESQVNKLRAKTRDFTS 1930
Score = 105 bits (263), Expect = 2e-22
Identities = 215/1193 (18%), Positives = 476/1193 (39%), Gaps = 160/1193 (13%)
Query: 311 SNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQ------AELIQQLQ------VL 358
S K E + +DI + + + +K T ++ A+LI + Q ++
Sbjct: 739 SKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLM 798
Query: 359 NMDTQKVLRNQEDVH----------TAESISYQKLYNELHICFETTKSNEAM--LRQSVT 406
++ QK+++ +E + + + KL+ ++ ++ ++ + M +++
Sbjct: 799 RVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQ 858
Query: 407 NLQDQLLQKEQENAKLKEKL----QESQGAPLPLPQESDPDYSAQ------VPHRPSLSS 456
+D+L + E + +L+EKL QE L + ES+ A+ + + L +
Sbjct: 859 KTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEA 918
Query: 457 LETLMVSQKSEIEYLQEKLKIANEKLSENISA-NKGFSRKSIMTSAEGKHKEPPVKRSRS 515
+ + + E + +L KL + S K + + K K + ++
Sbjct: 919 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 978
Query: 516 LSPKSSFTDS-----------------EELQKLRKAERKIENLEKALQLKSQENDELRDA 558
L+ + S D + L L+ E K+ +L K Q+ ++L +
Sbjct: 979 LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038
Query: 559 HEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYF 618
E+ K+ L+ N R ++ LK +E + ++ K+ ++L+++D + +
Sbjct: 1039 LEQEKKLRVDLERNKRKLEGDLKLAQES--ILDLENDKQQLDERLKKKDFEYCQLQSKVE 1096
Query: 619 KRENQELMIQKM--NLEEELDELKVHISIDKAA--------------IQELNRCVAE--- 659
+ L QK L+ ++EL+ I ++A ++EL+ + E
Sbjct: 1097 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGG 1156
Query: 660 ----------RREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSR 709
+RE + + D E E + ++ V EL ++ + ++ +
Sbjct: 1157 VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQ 1216
Query: 710 KLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELET 769
KL++ + E D L S ++ + EK + + +N E+Q +SEL T
Sbjct: 1217 KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTT 1276
Query: 770 EVTSLRRQVAEANALRNENEELINPMEKSHQS--------------ADRAKSEMATMKVR 815
+ + L+ + E + E E +++ + +S Q+ ++AK+ +A ++
Sbjct: 1277 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA-HALQ 1335
Query: 816 SGRYDC----------KTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGW 865
S R+DC + +++ +K N V + T + E K
Sbjct: 1336 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1395
Query: 866 EDVSESSSDSEA---------QTSQTLG------TIIVETSQKISPTEDGKDQKESDPTE 910
+ + +S EA +T Q L + VE + ++ D K +
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455
Query: 911 DSQTQGKEI---VQTYLNIDGKTPKDYFHDKNA------KKPTFQKKNCKMQKSSHTAVP 961
+ +T+ +E ++ L + F KNA + T +++N +++ A
Sbjct: 1456 EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ--EIADL 1513
Query: 962 TRVNREKYKNI-TAQKSSSNIILLRERI-ISLQQQNSVLQNAKK---TAELSVKEYK-EV 1015
T E K I +KS I L + I ++L++ + L++ + +L + + K E+
Sbjct: 1514 TEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEI 1573
Query: 1016 NEKLLHQQQVSDQRFQTSRQTIKKLNLDL-AGLRKEKEDLLKKLESSSEITSLAEENSQV 1074
+ K+ + + +Q + ++T++ + L A +R E + K + ++ + + S
Sbjct: 1574 DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA 1633
Query: 1075 TFPRIQVTSLSPSRSMDLEMKQLQYKLKNAT--NELTKQSSNVKTLKFELLAKEEHIKEM 1132
R +L RS+ ++K Q L +A E K+ + + LL E ++E+
Sbjct: 1634 N--RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAE--VEEL 1689
Query: 1133 HEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSI 1192
+ + ER + + D R ++ N S + L+ + L E +
Sbjct: 1690 RATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDA 1749
Query: 1193 DSLKQRLNVAVKEKSQYEQMYQKSKE-----ELEKKDLKLTL--LVSRISETESAMAEIE 1245
+ +++ A+ + + + +K ++ E KK+L+ T+ L R+ E E +
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK-- 1807
Query: 1246 TAASKQLQELALQSEQV---LEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQI 1302
KQ+Q+L + ++ LEG QK + + + ++ VK L + + D V R
Sbjct: 1808 -GGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQ 1866
Query: 1303 RELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKID 1355
+ K++ + K +A A + L R E+ + E++ +I +++++
Sbjct: 1867 DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVN 1919
Score = 67.4 bits (163), Expect = 9e-11
Identities = 142/708 (20%), Positives = 282/708 (39%), Gaps = 130/708 (18%)
Query: 101 RTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR 160
R Q EE+ + + AL +A+ E + W+ T+ + + L ++K +D
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEV--AQWRTKYETDA-IQRTEELEEAKKKLAQRLQDS 1401
Query: 161 KVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQ 220
+ E ++ +AK E+ + L+ E+ DL+ VD E A + L+KK ++ +
Sbjct: 1402 E--EQVEAVNAKCASLEKTKQRLQGEVEDLM-----VDVERA--NSLAAALDKKQRNFDK 1452
Query: 221 EIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDA 280
+ + K K E+++ ++ +E++ LST L N E+ Q +++E + +
Sbjct: 1453 VLAEWK----TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 1508
Query: 281 KIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL---QELQNL 337
+I + + E K + L+ S KQ EL + D+ + L E E +
Sbjct: 1509 EIADLTEQIAENGKTIH---------ELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 1559
Query: 338 YKQNSTHTAQQAELIQQLQVLNMDTQKVLRN-QEDVHTAESISYQKLYNELHICFETTKS 396
+ T ++E+ +++ + + +++ RN Q V T +S + E
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA----------LDAEVRSR 1609
Query: 397 NEAM-----LRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHR 451
NEA+ + + ++ QL ++ A+ + L+ QG D Q +
Sbjct: 1610 NEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK 1669
Query: 452 PSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVK 511
L+ +E ++E+E L+ L+ +
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLE--------------------------------QTE 1697
Query: 512 RSRSLSPKSSFTDSEELQKLRKAERKIENLEKAL-----QLKSQENDELRDAHEKRKERL 566
R+R L+ + +E +Q L + + +K L QL+S+ D RDA +E+
Sbjct: 1698 RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDA-RNAEEKA 1756
Query: 567 QMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELM 626
+ T+ + E+LK+ ++ S A+ +R + L
Sbjct: 1757 KKAITDAAMMAEELKKEQDTS----------------------------AHLERMKKNLE 1788
Query: 627 IQKMNLEEELDEL-KVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKE 685
+L+ LDE ++ + K IQ+L + E E + E K++T G
Sbjct: 1789 QTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFEL------EGEQKKNTESVKGLR 1842
Query: 686 MLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQ 745
E ++V EL + + K +L++ KL + +KS +Q +E E L +
Sbjct: 1843 KYE---RRVKELTYQSEEDRKNVLRLQDLVDKLQVK---VKSYKRQAEEADEQANAHLTK 1896
Query: 746 IIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALR---NENEE 790
K ++E E + + E++V LR + + + R +E+EE
Sbjct: 1897 FRKAQHELE----EAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 132 bits (333), Expect = 2e-30
Identities = 272/1321 (20%), Positives = 533/1321 (40%), Gaps = 202/1321 (15%)
Query: 92 ISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVERE 151
++ ++A + Q + L+ L E+ A + + + L + + L + + + +
Sbjct: 244 LTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLK 303
Query: 152 KQKSEAKDRKVLEILQVK---DAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEF 208
+KS+ DRK+ ++ + K++EF L+ +N+L + +E +L K+
Sbjct: 304 TEKSQM-DRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQE--WLEKQ- 359
Query: 209 SDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCT----DLLND---L 261
+ LEK+ Q+ K+C++ K E + + LEE +L ++L D L
Sbjct: 360 AQLEKELSAALQD----KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQL 415
Query: 262 EKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKD 321
E L+++ A L A+++ E + ++ + + QLS+ T+L
Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475
Query: 322 MDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQ 381
+++ ++EL++ + + TAQ A L +L LN Q Q+D A + Q
Sbjct: 476 SNLSQAKEELEQASQAH--GARLTAQVASLTSELTTLNATIQ-----QQDQELA-GLKQQ 527
Query: 382 KLYNELHICFETTKSNEAM--LRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQE 439
+ + + +A LR V L L QKEQ+ ++ EK + ++
Sbjct: 528 AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLAT 587
Query: 440 SDPDYSAQVPHRPS-LSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIM 498
+ + A + R + L LE L + +++E LQ++L++ANE +R S
Sbjct: 588 AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE------------ARDSAQ 635
Query: 499 TSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDA 558
TS +E + SR + + ++ Q+ +A+ ++ LE LQL+S++ +
Sbjct: 636 TSVTQAQRE-KAELSRKVEELQACVETAR-QEQHEAQAQVAELE--LQLRSEQ--QKATE 689
Query: 559 HEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYF 618
E+ + LQ +A+KE LK + G E K + AD + +Q ++
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTK---GSLEEEKRRAADALEEQQRC-------ISEL 739
Query: 619 KRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRST 678
K E + L+ Q +EL+E + +A +Q+L A + E ++ R + +
Sbjct: 740 KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE--AHQAETEVLRR---ELAEAMA 794
Query: 679 PEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTET 738
+ + EQ +++V R + QQE+ +
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYED---------------------------SQQEEAQY 827
Query: 739 REKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKS 798
EQ++ ++ EK ELQ E + +V + +E R +NE + +
Sbjct: 828 GAMFQEQLMTLKEECEKARQELQ----EAKEKVAGIESH-SELQISRQQNE-----LAEL 877
Query: 799 HQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFE 858
H + RA ++ +VR+ + + + K A K V R T++ + +
Sbjct: 878 HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSK--EVARLETLVRKAGEQQETASR 935
Query: 859 NLSKD---------GWEDVSESSSDSEAQTS-QTLGTIIVETSQKISPTEDGKDQKESDP 908
L K+ W + + Q + Q + + ++ + +
Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ 995
Query: 909 TEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREK 968
E+ Q +E+ + G+ D +K A+ + ++Q + +N ++
Sbjct: 996 QEERGQQEREVAR-LTQERGRAQADLALEKAAR----AELEMRLQNA--------LNEQR 1042
Query: 969 YKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQ 1028
+ T Q++ ++ +L ++ Q K L + KE+ E
Sbjct: 1043 VEFATLQEALAH---------ALTEKEGKDQELAKLRGLEAAQIKELEE----------- 1082
Query: 1029 RFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSR 1088
RQT+K+L LA +KEKE S S S A ++ T P+++ S+
Sbjct: 1083 ----LRQTVKQLKEQLA--KKEKEH-----ASGSGAQSEAAGRTEPTGPKLEALRAEVSK 1131
Query: 1089 SMDLEMKQ------LQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERD 1142
KQ L+ L+ ++ S ++TL+ +L K + + ++ +R+
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
Query: 1143 ITMKRHLIED---LKFRQKVNLESNKSFSE----MLQNLDKKVKTLTEECSNKKVSIDSL 1195
+ R ++D + K + + +E ++ +L+++V L + K+ L
Sbjct: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251
Query: 1196 KQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAM----------AEIE 1245
K RL +A EKS QK +E L + +R +E SA+ AE +
Sbjct: 1252 K-RLVMAESEKS------QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ 1304
Query: 1246 TAASKQL-QELALQSEQVLEGA-----------QKTLLLANEKVEEFTTFVKALAKELQN 1293
AS+ L QEL Q+E+ E QK L+ ++E +T +AL EL
Sbjct: 1305 RVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTST--QALVSELLP 1362
Query: 1294 DVHVVRR-QIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQV-EIEK 1351
H+ ++ Q + K++R+ + S A L A +L R +L E++ +V E E+
Sbjct: 1363 AKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQR-ELGELIPLRQKVAEQER 1421
Query: 1352 T 1352
T
Sbjct: 1422 T 1422
Score = 124 bits (311), Expect = 6e-28
Identities = 256/1336 (19%), Positives = 527/1336 (39%), Gaps = 192/1336 (14%)
Query: 72 AAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWK 131
A+ AH L+A + S E ++ + Q ++EL+ LK++ QA L +
Sbjct: 488 ASQAHGARLTAQVASLTSELTTLNATI----QQQDQELAGLKQQAKEKQAQ------LAQ 537
Query: 132 RLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLV 191
LQ +Q + VE+ + K++++ E+ + ++A Q+ Q+ + +E
Sbjct: 538 TLQ-QQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE----- 591
Query: 192 KRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLS 251
R+ ++ E +A L K+ LEK+ K + ++ + + + + + E +LS
Sbjct: 592 -REASLRERDAAL-KQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 252 TRCTDLLNDLEKLRKQ-----------EAHLRKEKYSTDAKIKTFEDN---------LIE 291
+ +L +E R++ E LR E+ K + ++ L E
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 709
Query: 292 ARKEVEVSQSKYNALSLQLSNKQTELIQ--KDMDITLVRKELQELQNLYKQNSTHTAQQA 349
+ K + S + + +Q I K +LV + +E + L ++ + +A
Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
Query: 350 ELIQQLQVLNMDTQKVLRNQEDV----HTAESISYQKLYNELHICFETTKSNEAMLRQSV 405
L Q + +T+ + R + HTAES ++L E+ E + ++ Q
Sbjct: 770 RLQQLGEAHQAETEVLRRELAEAMAAQHTAES-ECEQLVKEVAAWRERYEDSQQEEAQYG 828
Query: 406 TNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQK 465
Q+QL+ ++E K +++LQE++ + S+ S Q L + + Q
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQV 888
Query: 466 SEIEYLQEKLKIANEKLSENISA-NKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTD 524
E E +KL L E ++A +K +R + G+ +E SR L + +
Sbjct: 889 QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA---SRELVKEPARAG 945
Query: 525 SEELQKLRKAE-RKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQW 583
+ + L + + R+ + + ALQ +E +++ +E + R ++++ + +E+ +Q
Sbjct: 946 DRQPEWLEEQQGRQFCSTQAALQAMEREAEQM--GNELERLRAALMESQGQQQEERGQQE 1003
Query: 584 EEGSGMTEIR----------KIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLE 633
E + +T+ R K RA+ + Q + E A + + +K +
Sbjct: 1004 REVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKD 1063
Query: 634 EELDELKVHISIDKAAIQELNRCV-------AERREEQLFRSGEDDEVKRSTPEKNGK-- 684
+EL +L+ + ++EL + V A++ +E SG E T K
Sbjct: 1064 QELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE 1123
Query: 685 ------EMLEQTLQKVTE----------------------LENRLKSFEKRSRKLKEGNK 716
LEQ QK E LE E+++++L
Sbjct: 1124 ALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQS 1183
Query: 717 KLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRR 776
L L + + Q+ ++ ++ Q+ +G ++ E++N+ IS LE EV+ L R
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS----LISSLEEEVSILNR 1239
Query: 777 QVAEANALRNENEELINP-MEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKK 835
QV E E + L+ EKS + +R + A S R AA++
Sbjct: 1240 QVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR-------------AAER 1286
Query: 836 NCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKIS 895
+ ++ L + ENL ++ S+A+ ++ LG + +K
Sbjct: 1287 SSALREEVQSLREEAEKQRVASENLRQE---------LTSQAERAEELGQELKAWQEKFF 1337
Query: 896 PTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCK-MQK 954
E + + T +Q E++ K A++ +K++ + +++
Sbjct: 1338 QKEQALSTLQLEHTS-TQALVSELLPA---------KHLCQQLQAEQAAAEKRHREELEQ 1387
Query: 955 SSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKE 1014
S A R + AQ+ +I LR+++ ++ L+ K + + K+
Sbjct: 1388 SKQAAGGLRAEL-----LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442
Query: 1015 VNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQV 1074
+ L + + +R RQ L ++L R++ L + + +E T LAE
Sbjct: 1443 AHGLLAEENRGLGERANLGRQF---LEVELDQAREKYVQELAAVRADAE-TRLAE----- 1493
Query: 1075 TFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHE 1134
+Q + ++ EL ++ + K ++L + + +E +
Sbjct: 1494 ----------------------VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQ 1531
Query: 1135 KISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDK-------KVKTLTEECSN 1187
K++ +E L+ Q+ + + S+ L + D+ K+K + +
Sbjct: 1532 KLTAQ----------VEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGE 1581
Query: 1188 KKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETA 1247
+ L+ +LN + SQ EQ + K ++EK + E + + +E
Sbjct: 1582 SQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLE-Q 1640
Query: 1248 ASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKK 1307
K+ +EL ++E++ Q+ L E E+ + A + L+ V +Q+R+L K
Sbjct: 1641 LQKENKELRAEAERLGHELQQAGLKTKE-AEQTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Query: 1308 MKKNRDACKTSTHKAQ 1323
+ DA K+ +A+
Sbjct: 1700 FQVATDALKSREPQAK 1715
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 131 bits (329), Expect = 5e-30
Identities = 262/1312 (19%), Positives = 545/1312 (41%), Gaps = 204/1312 (15%)
Query: 183 LKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKN 242
L + ++ L+ K +++ L+KE ++++ +D ++ D + ++ I+N
Sbjct: 74 LTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIEN 133
Query: 243 LEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIK-TFEDNLIEARKEVEVSQS 301
L+ E + ++ ++ +L+K + +EA + + S K + EDN+ + ++E+E +
Sbjct: 134 LKNELMAVRSKYSEDKANLQK-QLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRP 192
Query: 302 KYNALSLQLSNKQTELIQKDMDITLVRKE--LQELQNLYKQNSTHTAQQAELIQ----QL 355
+ +Q +QK +D T K+ + +LQN+ + NS H + +Q QL
Sbjct: 193 GF--------EEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQL 244
Query: 356 QVLNMDTQKVLRNQEDVHTAESISYQKLYNEL---------------------------- 387
+ ++ + K L Q + E + NEL
Sbjct: 245 KAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRK 304
Query: 388 ---------HICFETTKSN---EAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLP 435
IC + N E ++ + V +L+D L + E +++ LK+++ L
Sbjct: 305 ATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLK 364
Query: 436 LPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRK 495
L ++ R L ++ K E + EKLK SE NK F
Sbjct: 365 LEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLK------SELAGLNKQFCYT 418
Query: 496 SIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDEL 555
+ E + + ++ S ++ +DSE+ + E I+ L++ + QE E
Sbjct: 419 VEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFE--IQGLKEQCENLQQEKQEA 476
Query: 556 RDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQE------DSD 609
+E +E +++LQT ++ Q E +++ + +D +L+Q+ + D
Sbjct: 477 ILNYESLREIMEILQTELGESAGKISQEFE-----SMKQQQASDVHELQQKLRTAFTEKD 531
Query: 610 AVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSG 669
A+ + + EN++L+ Q+ L EL+ ++ +K + L+ + ++L
Sbjct: 532 ALLETVNRLQGENEKLLSQQ-ELVPELENTIKNLQ-EKNGVYLLSLSQRDTMLKEL---- 585
Query: 670 EDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLL 729
+ ++ T EK+ + + + E++N K E+ R + E KK+ + + L
Sbjct: 586 -EGKINSLTEEKD--DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELE 642
Query: 730 KQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENE 789
++ E T E+ L++ K D + E +Q+K+ + EV S AE +L EN
Sbjct: 643 QKVNELTGGLEETLKE--KDQNDQKLEKLMVQMKVLSEDKEVLS-----AEVKSLYEENN 695
Query: 790 ELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHS 849
+L + EK S D ++V F + K++ + H T L
Sbjct: 696 KLSS--EKKQLSRD--------LEV---------------FLSQKEDVILKEHITQLEKK 730
Query: 850 IKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPT 909
+++M +NL+K + E+ + L + E ++S +D +E D
Sbjct: 731 LQLMVEEQDNLNK-----LLENEQVQKLFVKTQLYGFLKEMGSEVS-----EDSEEKDVV 780
Query: 910 EDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKY 969
Q G+ + + + + ++ K +K+ +Q+ S V E+
Sbjct: 781 NVLQAVGESLAKI-----NEEKCNLAFQRDEKVLELEKEIKCLQEES------VVQCEEL 829
Query: 970 KNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQR 1029
K++ +LLR+ + +Q + LQ+ + E K NEK + Q +
Sbjct: 830 KSLLRDYEQEK-VLLRKELEEIQSEKEALQS-------DLLEMKNANEKTRLENQNLLIQ 881
Query: 1030 FQTSRQTIKKLNLDLAGLR---KEKEDLLKKLESSSEITSLAE----ENSQVTFPRIQVT 1082
+ QT K + + KE E+L LE AE ++S P ++
Sbjct: 882 VEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKND 941
Query: 1083 SLSPSRSMDLEMKQLQYKLK--------------NATNELTKQSSNVKTLKFELLAKEEH 1128
LS + ++ +++ L+ + K A EL +T+K EL E
Sbjct: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEEL----ES 997
Query: 1129 IKEMHEKISRMERDI-----TMKRHLIEDLKFRQKVNLESNK--SFSEMLQNLDKKVKTL 1181
++ +++S RD+ + K L+E K +++++E + +F +++L ++++
Sbjct: 998 LRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNS 1057
Query: 1182 TEECSNKKVSIDSLKQR----------LNVAVKEKSQYEQMYQKSKE-ELEKKDLKLTLL 1230
T +C + L R L V + E + + M K E E +K+ K+
Sbjct: 1058 TLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH 1117
Query: 1231 VSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKE 1290
+ ++E E +++ KQLQ+ + E V + AQ+T L+ N ++ ++ +K L ++
Sbjct: 1118 ATTVNELEELQVQLQ-KEKKQLQKTMQELELVKKDAQQTTLM-NMEIADYERLMKELNQK 1175
Query: 1291 LQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSD--LEEILDTEDQVE 1348
L N + + +E+K K+ ++ T + +L +S+ + ++++L V+
Sbjct: 1176 LTNKNNKIEDLEQEIKIQKQKQE---TLQEEITSLQSSVQQYEEKNTKIKQLL-----VK 1227
Query: 1349 IEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEA----VLEKINEKKKLVE 1396
+K D++ + L +Q L+G+L + +E + E +EK K+ E
Sbjct: 1228 TKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHE 1279
Score = 123 bits (308), Expect = 1e-27
Identities = 234/1223 (19%), Positives = 516/1223 (42%), Gaps = 128/1223 (10%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ 153
+ + + Q ++ L+++L +K+ + RLQ N L LV E E
Sbjct: 501 ISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENT 560
Query: 154 KSEAKDRKVLEILQV--KDAKIQEFEQRESVLKQEINDLV-KRKIAVDEENAFLRK---- 206
+++ + +L + +D ++E E + + L +E +D + K K + +E + F +K
Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE 620
Query: 207 ----------------EFSDLEKKFKDKSQEIKDT-KECVQNKEEQNRLVI--KNLEEEN 247
S+LE+K + + +++T KE QN ++ +L++ K L E+
Sbjct: 621 ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDK 680
Query: 248 KKLSTRCTDLLNDLEKLRKQEAHLRK--EKYSTDAKIKTFEDNLIEARKEVEVSQSKYNA 305
+ LS L + KL ++ L + E + + + ++++ + K++++ + +
Sbjct: 681 EVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDN 740
Query: 306 LSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKV 365
L+ L N+Q +QK T + L+E+ + ++S ++ +++ LQ + K+
Sbjct: 741 LNKLLENEQ---VQKLFVKTQLYGFLKEMGSEVSEDS----EEKDVVNVLQAVGESLAKI 793
Query: 366 LRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTN---LQDQLLQKEQENAKL 422
N+E + A + L E K + + +SV L+ L EQE L
Sbjct: 794 --NEEKCNLAFQRDEKVL--------ELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL 843
Query: 423 KEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKL 482
+++L+E Q L +SD + L + L+ Q E+ K +I NEK
Sbjct: 844 RKELEEIQSEKEAL--QSDLLEMKNANEKTRLENQNLLI--QVEEVSQTCSKSEIHNEK- 898
Query: 483 SENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLE 542
E + + K ++ E + + + + KS ++ L +++ E KIENLE
Sbjct: 899 -EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 543 KALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQ 602
K + K ++ ++++ K K+ L + + VKE+L+ R++ Q
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL-------------RSEKDQ 1004
Query: 603 LRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERRE 662
L D + +Y + L+++ E+LD K + + I++L R +
Sbjct: 1005 LSASMRDLIQGAESY-----KNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTL 1059
Query: 663 E-QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
+ + S +D + R ++ ++LE + +V + + E + KL++ K +KE
Sbjct: 1060 QCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDK-ELEAEKLQKEQK--IKE 1116
Query: 722 NDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKE---NTELQVKISELETEVTSLRRQV 778
+ + L++ Q + +K+L++ ++ + V+K+ T + ++I++ E + L +++
Sbjct: 1117 HATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKL 1176
Query: 779 AEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCS 838
N N+ E+L ++ Q + + E+ +++ +Y+ K T K KK +
Sbjct: 1177 TNKN---NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233
Query: 839 VGRH----HTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKI 894
+ H +L S+K + + ++E +S+ + + L T + + +
Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKH-KIHEHLKTSAEQHQRTL 1292
Query: 895 SPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHD--KNAKKPTFQKKNCKM 952
S + Q+ + E+ + E Q + + ++ K H+ K K + + +
Sbjct: 1293 SAYQ----QRVTALQEECRAAKAE--QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEG 1346
Query: 953 QKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQN-SVLQNAKKTAELSVKE 1011
K + +++ K K Q S +N+ + + +LQ ++ ++L+ K + +V +
Sbjct: 1347 AKQEREHLEMLIDQLKIK---LQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSK 1403
Query: 1012 YKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEEN 1071
E+ EKL Q + QT+ +L LR D ++ L +E
Sbjct: 1404 EAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL----------QEE 1453
Query: 1072 SQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKE 1131
+ T +Q + +E + Q K + T ++K L+ E + + +
Sbjct: 1454 HRKTVETLQ------QQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLR-ERRNTDLPLLD 1506
Query: 1132 MHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKT-LTEECSNKKV 1190
MH T+ R E ++ ++ S ++++ L+ L +T L + +
Sbjct: 1507 MH----------TVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEF 1556
Query: 1191 SIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAAS- 1249
+ + L Q+L+ K + ++++ ++ LL S I E ++AA+
Sbjct: 1557 TKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANL 1616
Query: 1250 KQLQELALQSEQVLEGAQKTLLL 1272
+ L+ + LQ + G+++ LL
Sbjct: 1617 EYLKNVLLQFIFLKPGSERERLL 1639
Score = 115 bits (287), Expect = 4e-25
Identities = 265/1344 (19%), Positives = 546/1344 (40%), Gaps = 160/1344 (11%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ 153
+EEAM T+ +L E+L ++ V L + ++ P + + + ++
Sbjct: 156 LEEAMNTQLEL--------SEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDA 207
Query: 154 KSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEK 213
++ K V ++ + +A Q +++ + L++E+ L A+ +E +++ +E
Sbjct: 208 TTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLK----AIHQEE--VKELMCQIEA 261
Query: 214 KFKDKSQEIKDTKECVQNKEEQNRLVIKNLEE------ENKKLSTRCTDLLNDLEKLRKQ 267
K+ EI E +N +Q KN+++ EN + +T + N + + Q
Sbjct: 262 SAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 321
Query: 268 EAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLV 327
E ++ + K+K ED L KE+E S+++ L +++ ++ +MD +
Sbjct: 322 ENTFVEQV--VNEKVKHLEDTL----KELE---SQHSILKDEVTYMNNLKLKLEMDAQHI 372
Query: 328 RKEL-QELQNL-YKQNSTHTAQQAE--LIQQLQVLNMDTQKVLRNQEDVHTAESIS---- 379
+ E E ++L +K N A++ + +I++L+ K + H E S
Sbjct: 373 KDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQ 432
Query: 380 YQKLYNELHICFETTKSNEAM-LRQSVTNLQDQL--LQKEQENAKLKEKLQESQGAPLPL 436
+QK +EL+ F + E + L + L++Q LQ+E++ A L ES + +
Sbjct: 433 HQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILN---YESLREIMEI 489
Query: 437 PQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIA---NEKLSENISANKGFS 493
Q + + ++ E++ Q S++ LQ+KL+ A + L E ++ +G +
Sbjct: 490 LQTELGESAGKISQE-----FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGEN 544
Query: 494 RKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKA----LQLKS 549
K + E +K + + + S+ L++ E KI +L + +
Sbjct: 545 EKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604
Query: 550 QENDELRDAHEK--RKERL------QMLQT-NYRAVKEQLKQWEEGSGMTEIRKIKRADP 600
++E+ + H+K R+ERL ++ QT Y + EQ K E G+ E K K +
Sbjct: 605 NSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQ-KVNELTGGLEETLKEKDQND 663
Query: 601 QQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAER 660
Q+L ++LM+Q L E+ + L + K+ +E N+ +E+
Sbjct: 664 QKL-------------------EKLMVQMKVLSEDKEVLSAEV---KSLYEENNKLSSEK 701
Query: 661 ----REEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNK 716
R+ ++F S ++D + K LE+ LQ + E ++ L + + K K
Sbjct: 702 KQLSRDLEVFLSQKEDVIL-----KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVK 756
Query: 717 KLMKENDFLKSLLKQQQEDTETRE--KELEQIIKGSKDVEKENTELQV----KISELETE 770
+ FLK + + ED+E ++ L+ + + + +E L K+ ELE E
Sbjct: 757 TQLY--GFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKE 814
Query: 771 VTSLRR----QVAEANALRNENEE----LINPMEKSHQSADRAKSEMATMKVRSGRYDCK 822
+ L+ Q E +L + E+ L +E+ + +S++ MK + + +
Sbjct: 815 IKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLE 874
Query: 823 TTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQT 882
++ + + CS H N K ENL K E + D A+
Sbjct: 875 NQNLLIQVEEVSQTCSKSEIH---NEKEKCFIKEHENL-KPLLEQ--KELRDRRAELILL 928
Query: 883 LGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKK 942
++ S K P K+ +E + + + KE + + K D + K+
Sbjct: 929 KDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL-DSSRKE 987
Query: 943 PTFQKKNCKMQKSSHTAVPTRVN-----REKYKNITAQ--KSSSNIILLRERIISLQQQN 995
K+ + +S + + E YKN+ + K S + + +ER + + +
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Query: 996 SVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLL 1055
L + + L + NE LL R +T + K L + + +++ K +
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLL-------ARIETLQSNAKLLEVQILEVQRAKAMVD 1100
Query: 1056 KKLESSS--EITSLAEENSQVT-FPRIQVTSLSPSRSMDLEMKQLQYKLKNATN------ 1106
K+LE+ + + E + V +QV + + M++L+ K+A
Sbjct: 1101 KELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM 1160
Query: 1107 ELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKS 1166
E+ +K L +L K I+++ ++I ++ + I L+ + E N
Sbjct: 1161 EIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTK 1220
Query: 1167 FSEMLQNLDKKVKTLTEECSNKKVSID------SLKQRLNVAVKEKSQYEQMYQKSKEEL 1220
++L VKT E +K+ D SLK L + ++ Y+ + E
Sbjct: 1221 IKQLL------VKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEK 1274
Query: 1221 EKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANE--KVE 1278
K L + T SA + TA ++ + + V + + + K +
Sbjct: 1275 HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQ 1334
Query: 1279 EFTTFVKALAKELQNDVHVVRRQIRELK-KMKKNRDACKTSTHKAQTLAA---SILNISR 1334
+ + +A + + + + I +LK K++ +++ + + + QTL + ++L
Sbjct: 1335 KNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN 1394
Query: 1335 SDLEEILDTEDQVEIEKTKIDAEN 1358
L+E + E ++ + I +EN
Sbjct: 1395 KMLQETVSKEAELREKLCSIQSEN 1418
Score = 108 bits (270), Expect = 4e-23
Identities = 263/1253 (20%), Positives = 493/1253 (39%), Gaps = 211/1253 (16%)
Query: 210 DLEKKFKDKSQEIKDTKE-CVQNKEEQNRLVIKNLEEEN----KKLSTRCTDLLNDLEKL 264
DL K K + I+ K C + ++E L K + E K L+ R LL + +
Sbjct: 29 DLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAET 88
Query: 265 RKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDI 324
+Q L+KE +++ + +A KE+E S Y ++ N + EL+
Sbjct: 89 EQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVK---EIENLKNELM------ 139
Query: 325 TLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAE-SISYQKL 383
+ K ++ NL KQ Q EL +QL+ N V + QE++ Q L
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQIL 199
Query: 384 YNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPD 443
Y + + T + E +VT LQ+ + Q K LQE + QE +
Sbjct: 200 YLQKQLDATTDEKKE-----TVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKE 254
Query: 444 YSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEG 503
Q+ E ++EI L E L EN+ S K+I E
Sbjct: 255 LMCQI---------EASAKEHEAEINKLNE--------LKENLVKQCEASEKNIQKKYEC 297
Query: 504 KHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRK 563
EL+ LRKA + + QEN + ++
Sbjct: 298 -----------------------ELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334
Query: 564 ERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLR------QEDSDAVWNELAY 617
+ L+ + LK +E + M ++ D Q ++ +ED + NEL
Sbjct: 335 KHLEDTLKELESQHSILK--DEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLL 392
Query: 618 FKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRS 677
K E Q +I+K L+ EL L +++ NR V +E+ E +E S
Sbjct: 393 AKEE-QGCVIEK--LKSELAGLNKQFCY---TVEQHNREVQSLKEQHQKEISELNETFLS 446
Query: 678 TPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTE 737
EK +K+T L ++ +++ L++ ++ + + L+ +++ Q +
Sbjct: 447 DSEK----------EKLT-LMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495
Query: 738 TREKELEQIIKGSKDVEKENT-ELQVKISELETEVTSLRRQVAEANALRNENEELINPME 796
++ Q + K + + ELQ K+ TE +L V N L+ ENE+L++ E
Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETV---NRLQGENEKLLSQQE 552
Query: 797 KSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNV 856
+ + K+ ++ ++G Y + K + + S+ +
Sbjct: 553 LVPELENTIKN----LQEKNGVYLLSLSQRDTMLKELEGKIN----------SLTEEKDD 598
Query: 857 FENLSKDGWEDVSE--SSSDSEAQTSQTLGTIIVET-------SQKISPTEDGKDQKESD 907
F N K+ E++ + E + LG + +T QK++ G ++ +
Sbjct: 599 FINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKE 658
Query: 908 PTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNRE 967
++ Q K +VQ + + K +A+ + ++N K+ ++
Sbjct: 659 KDQNDQKLEKLMVQMKVLSEDKEVL------SAEVKSLYEENNKLSSEK---------KQ 703
Query: 968 KYKNITAQKSSSNIILLRERIISLQQQ-----------NSVLQNAKKTAELSVKEY---- 1012
+++ S ++L+E I L+++ N +L+N ++ +L VK
Sbjct: 704 LSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLEN-EQVQKLFVKTQLYGF 762
Query: 1013 -KEVNEKLLHQQQVSD--QRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAE 1069
KE+ ++ + D Q +++ K+N + L ++++ K LE EI L E
Sbjct: 763 LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDE--KVLELEKEIKCLQE 820
Query: 1070 ENSQVT---------FPRIQVTSLSPSRSMDLEMKQLQ---YKLKNATNELTKQSSNVKT 1117
E+ + + +V + E + LQ ++KNA NE T+ +
Sbjct: 821 ESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNA-NEKTRLENQNLL 879
Query: 1118 LKFELLAKEEHIKEMH-EKISRMERDITMKRHLIEDLKFRQK----VNLESNKSFSEMLQ 1172
++ E +++ E+H EK ++ + L+E + R + + L+ + + S ++
Sbjct: 880 IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVK 939
Query: 1173 N--------LDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKD 1224
N L++K++ L +EC K+ I+ +K VAVK K +
Sbjct: 940 NDPLSSVKELEEKIENLEKECKEKEEKINKIKL---VAVKAKKE---------------- 980
Query: 1225 LKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQ--KTLLLANEKVEEFTT 1282
L S ET++ E+E+ S++ +L+ +++GA+ K LLL EK E
Sbjct: 981 -----LDSSRKETQTVKEELESLRSEK-DQLSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034
Query: 1283 FVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNI-SRSDLEEIL 1341
K A ++ + + RQ+R + C+T + L A I + S + L E+
Sbjct: 1035 VEKERANNFEHRIEDLTRQLR------NSTLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088
Query: 1342 DTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKL 1394
E V+ K +D E + E + QK+ E + L E ++ EKK+L
Sbjct: 1089 ILE--VQRAKAMVDKELEAEKLQKEQKIKE-HATTVNELEELQVQLQKEKKQL 1138
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 128 bits (322), Expect = 3e-29
Identities = 242/1246 (19%), Positives = 486/1246 (39%), Gaps = 156/1246 (12%)
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEF 208
+R++Q+ + + + + Q ++ + E EQ +S E + +E R+E
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF-------PDEEQLRRREL 215
Query: 209 SDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQE 268
+L +K +++ Q+ Q +E Q+R+ EEE K+ R T L + EKL+++E
Sbjct: 216 LELRRKGREEKQQ--------QRRERQDRVF---QEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 269 AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVR 328
++E + +++ E + ++ E Q + QL KQ E ++ + +
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 329 KELQELQNLYKQNSTHTAQQAELIQQL---QVLNMDTQKVLRNQEDVHTAESISYQKLYN 385
+E +E Q ++ Q+ QQL Q Q++ R QE E Q+L
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE-----EERREQQLRR 379
Query: 386 ELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYS 445
E + E E LR+ ++Q L++EQ+ + ++ +E Q L +E + +
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ-----LRREQEEERH 434
Query: 446 AQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKH 505
QK E E +++LK E+ R+ + E
Sbjct: 435 -----------------EQKHEQERREQRLKREQEE------------RRDWLKREEETE 465
Query: 506 KEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKER 565
+ +R + L E KL + ER+ + + QL+ +E +E R+ KR+E
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR-REQEERREQRLKRQEE 524
Query: 566 LQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQEL 625
+ LQ R+ ++ ++ EE + +KR + ++L QE + KRE +E
Sbjct: 525 EERLQQRLRSEQQLRREQEE----RREQLLKREEEKRLEQERREQ------RLKREQEER 574
Query: 626 MIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKE 685
Q + EEE + ++ ++ Q L R ER E++ R + +KR PE+ E
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR---EQRLKREEPEE---E 628
Query: 686 MLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQ 745
+Q L+ + E R + + ++ +E K +E + L+ LK++ E+ E RE+EL +
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE-ERREQELAE 687
Query: 746 -------------IIKGSKDVEKENTELQVKI-SELETEVTSLRRQVAEANALRNENEEL 791
I K +E E Q K+ S + RRQ E R E+E
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 792 INPMEKSHQSADRAKSE-------MATMKVRSGRY--DCKTTMTKVKFKAAKKNCSVGRH 842
E++H+ + A K GR + + + + + + R
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807
Query: 843 HTVLNHSIKVMSNVFENLSKDG----WEDVSESSSDSEAQTSQTLGTIIVETSQKISPTE 898
L + + ++ E+ + AQ Q + E ++ E
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 899 DGKDQKESDPTEDSQTQ------GKEIVQTYLNIDGKTPKDYFHD----------KNAKK 942
+DQK E+ + + K +Q L + + ++ + + ++
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 943 PTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAK 1002
++++ Q+ R R + + + + E+++ + + Q +
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Query: 1003 KTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLD-----LAGLRKEKEDLLKK 1057
K +E ++ E+LL +++ +R + RQ KK L L +EK L ++
Sbjct: 988 KKYR-EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Query: 1058 LESSSEITSLAEENSQVTFPRIQVT---SLSPSRSMDLEMKQLQYKLKNATNELTKQSSN 1114
E L +E Q+ + L + E++Q + +L E ++
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106
Query: 1115 VKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSE----- 1169
+ + +EE +++ E++ R ER+ ++ L + ++V E + E
Sbjct: 1107 ERQCR-----EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR 1161
Query: 1170 MLQNLDKKVKTLTEECSNKKVSI---DSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLK 1226
Q L+++ + EE ++ + + K+R + + + E QK K+ +D +
Sbjct: 1162 RRQELERQYRE-EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 1227 LTLLVSRISETESAMAE-------IETAASKQLQELALQSEQVLEGAQKTLLLANEKVEE 1279
L E E+A+ + E +QL++ L+ Q + Q L E+ E
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE 1280
Query: 1280 FTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTL 1325
+ + Q D H + E ++ K+ + + S + Q L
Sbjct: 1281 -----QERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLL 1321
Score = 102 bits (254), Expect = 3e-21
Identities = 166/794 (20%), Positives = 336/794 (42%), Gaps = 129/794 (16%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDR----K 161
EEEL +E+L + +K W+R +L Q ++ E++K ++R +
Sbjct: 993 EEELQQEEEQLLREEREKRRRQE-WERQYRKKDELQQEEEQLLREEREKRRLQERERQYR 1051
Query: 162 VLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQE 221
E LQ ++ ++ E+RE+ +QE+ +++ + +E L +E + +++ +++ ++
Sbjct: 1052 EEEELQQEEEQLLG-EERETRRRQELERQYRKEEELQQEEEQLLREEPE-KRRRQERERQ 1109
Query: 222 IKDTKECVQ--------NKEEQNRLVIKNLEEENKKLSTRCTDLL-NDLEKLRKQEAHLR 272
++ +E Q +E++ R ++ E +++ LL + EK R+QE
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL--- 1166
Query: 273 KEKYSTDAKIKTFEDNLI--EARKEVEVSQSKY-NALSLQLSNKQTELIQKDMDITLVRK 329
+ +Y + +++ E+ L+ E K + + +Y LQ ++ +D L +
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 330 ELQELQNLYKQNSTHTA----QQAELIQQLQVLNMDTQKVLRN-----QEDVHTAESISY 380
E +N + N + +Q ++ Q+ + +Q+ L++ QE E +
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 381 QKLYNELHI----CFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEK----------- 425
Q+ + H E + EA R + + QLL++E+E + +++
Sbjct: 1287 QQ--RDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL 1344
Query: 426 LQESQGAPLPLPQESDPDYSAQVPHRP---SLSSLETLMVSQKSEIEYLQEKLKIANEKL 482
LQE + PL + ++ H+ E + Q+ E ++L+E+ ++ ++
Sbjct: 1345 LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQER 1404
Query: 483 SENI--SANKGFSRKSIMTSAEG-----KHKEPPVKRS------------------RSLS 517
+ + ++ F + S + + +E V+R R
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464
Query: 518 PKSSFTDSEELQKLRKAERKIENLEKALQLKSQEND------ELRDAHEKRK--ERLQML 569
+ E Q+L + ER + LE+ QL+ QE D ELR +RK E Q L
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 570 QTNYRAVK-----EQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQE 624
R K +QL++ E G + R K + +QLRQE RE Q+
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE-------------REEQQ 1571
Query: 625 LMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGK 684
L Q+ + + L+E KV RR+EQ + ED++ R + G+
Sbjct: 1572 LSRQERDRKFRLEEQKV------------------RRQEQERKFMEDEQQLR---RQEGQ 1610
Query: 685 EMLEQTL-QKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQ--EDTETREK 741
+ L Q +K E E L+ E++ +E ++K ++E L+ ++QQ D + + +
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670
Query: 742 ELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQS 801
E EQ+++ ++ + E K E E + LRRQ E L+ E + +E+ +
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQ---LRRQERERKFLQEEQQLRRQELERKFRE 1727
Query: 802 ADRAKSEMATMKVR 815
++ + E ++R
Sbjct: 1728 EEQLRQETEQEQLR 1741
Score = 99.0 bits (245), Expect = 3e-20
Identities = 245/1292 (18%), Positives = 493/1292 (38%), Gaps = 179/1292 (13%)
Query: 87 RRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKE-------FVWSLWKRLQVTNPD 139
R+ EG + + + E EL +EE A Q +E + W ++ +
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 140 LTQVVSLVVEREKQ-KSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVD 198
L+ L +RE+Q ++E + ++ L ++ K Q QR ++E+ L +
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE-REKELQFL-------E 835
Query: 199 EENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLL 258
EE R+E + ++ +D QE ++ + + + +Q LEEE K+
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW--QLEEERKRRRHTLYAKP 893
Query: 259 NDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELI 318
E+LRK++ L++E+ + E K Q + QL ++ +L+
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQRE---------EREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 319 QKDMDITLVRKELQELQNLYKQNSTHTAQQAELI--QQLQVLNMDTQKVLRNQEDVHTAE 376
+++ + ++ QE + Y+++ ++ +L+ + + + +K R +E++ E
Sbjct: 945 REERE----KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 377 SISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPL 436
Q L E + + + ++QLL++E+E +L+E+ ++ + L
Sbjct: 1001 E---QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE-EL 1056
Query: 437 PQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKS 496
QE + + R + L + E E QE+ ++ E+ +
Sbjct: 1057 QQEEEQLLGEERETRRR----QELERQYRKEEELQQEEEQLLREEPEKR----------- 1101
Query: 497 IMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELR 556
+ +E + L + EE +K R+ E + + E+ +++ +E LR
Sbjct: 1102 -----RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE-EVQQEEEQLLR 1155
Query: 557 DAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELA 616
+ EKR R Q L+ YR +E+L+Q EE E K ++ +Q R+E+ EL
Sbjct: 1156 EEPEKR--RRQELERQYRE-EEELQQEEEQLLREEQEKRRQERERQYREEE------ELQ 1206
Query: 617 YFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKR 676
KR+ Q+ E++ +LK +K N+ + RE + FR ED +++
Sbjct: 1207 RQKRK------QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260
Query: 677 STPEKNGKEMLEQTLQKVTELENRL-------------------KSFEKRSRKLKEGNKK 717
+++ + +L + ++ E E R K ++R RK +E +
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 718 LMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELET-------- 769
L +E + K+++++T+ + +E EQ+++ ++ E K E E
Sbjct: 1321 LREEREE-----KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 770 ---EVTSLRRQVAEANALRNENEELINPMEKS-HQSADRAKSEMATM--------KVRSG 817
E LRRQ E L+ E + E+ Q DR E K R
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE 1435
Query: 818 RYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEA 877
+ + KF ++ RH + + L + ++ + E
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR---QERDRKFLEEEQ 1492
Query: 878 QTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHD 937
Q + + S + K +E Q Q K + + + + D
Sbjct: 1493 QLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 938 KNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYK----NITAQKSSSNIILLRERIISLQQ 993
++ K F+++ Q+ + + K++ + Q+ + +++ +
Sbjct: 1553 RDRK---FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 994 QNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKK------LNLDLAGL 1047
Q + Q + + +E E+ LH+Q+ D++F +++ L D
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQE-RDRKFLEEEPQLRRQEREQQLRHDRDRK 1668
Query: 1048 RKEKEDLLKK-----LESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLK 1102
+E+E LL++ L EE Q+ R + E K LQ + +
Sbjct: 1669 FREEEQLLQEGEEQQLRRQERDRKFREEEQQL-------------RRQERERKFLQEEQQ 1715
Query: 1103 NATNELTKQSSNVKTLKFE-----LLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQ 1157
EL ++ + L+ E L +E + K + E+ R ER+ R D KFR+
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 1158 KVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSK 1217
+ E L+ ++ + ++E K + L+Q +E+ Q + K
Sbjct: 1776 E----------EQLRQEREEQQLRSQESDRKFREEEQLRQE-----REEQQLRPQQRDGK 1820
Query: 1218 EELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKV 1277
E++ L+L R+ + E + Q + + E E QK K+
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKL 1880
Query: 1278 EEFTTFVKALAKELQNDVHVVRRQIRELKKMK 1309
E ++ KE Q RQ+ E+K +
Sbjct: 1881 RE--EHIRRQQKEEQR-----HRQVGEIKSQE 1905
Score = 98.6 bits (244), Expect = 4e-20
Identities = 227/1268 (17%), Positives = 509/1268 (40%), Gaps = 180/1268 (14%)
Query: 124 EFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVL 183
EF+ ++K Q L Q L E ++ + + K+ + + Q +D + FE R+ L
Sbjct: 73 EFLLFIFKVAQACYYALGQATGLD-EEKRARCDGKESLLQDRRQEEDQR--RFEPRDRQL 129
Query: 184 KQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNL 243
++E ++K E +E S+ +++ + + ++ +D + Q +E Q R +
Sbjct: 130 EEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE 189
Query: 244 EEENKKLSTRCTDLLNDLEKLRKQEAH--LRKEKYSTDAKIKTFEDNLIEARKEVEVSQS 301
EE+ + T+ D E+LR++E RK + + + +D + + +E E +
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 302 KYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMD 361
+ T++RKE ++LQ Q ++ E +++L +
Sbjct: 250 E----------------------TVLRKEEEKLQEEEPQRQRELQEEEEQLRKL-----E 282
Query: 362 TQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAK 421
Q++ R +++ E Q+L E + + E R+ ++Q ++EQ+ +
Sbjct: 283 RQELRRERQE----EEQQQQRLRREQQL----RRKQEEERREQQEERREQQERREQQEER 334
Query: 422 LKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEK 481
+++L+ Q + ++ E E +++L+ E+
Sbjct: 335 REQQLRREQ------------------------EERREQQLRREQEEERREQQLRREQEE 370
Query: 482 LSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENL 541
R+ + + +E ++R + L + ++L++ ++ R+ + L
Sbjct: 371 ER----------REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQL 419
Query: 542 EKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQ 601
+ QL+ ++ +E + +++ R Q L+ ++ LK+ EE TE + +R Q
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE----TERHEQERRKQQ 475
Query: 602 QLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERR 661
R ++ + + K E +E Q+ E Q+L R ERR
Sbjct: 476 LKRDQEEE---RRERWLKLEEEERREQQERRE-----------------QQLRREQEERR 515
Query: 662 EEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKE 721
E++L R E+ E L+Q L+ +L R + E+R + LK +K + E
Sbjct: 516 EQRLKRQEEE-------------ERLQQRLRSEQQL--RREQEERREQLLKREEEKRL-E 559
Query: 722 NDFLKSLLKQQQEDTETR--EKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVA 779
+ + LK++QE+ + ++E E+ + K ++E E ++K E+E RR
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR--- 616
Query: 780 EANALRNE-NEELINPMEKSHQSADRAKSEM--ATMKVRSGRYDCKTTMTKVKFKAAKKN 836
E R E EE + KS + +R + ++ + R R + +++ + +++
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676
Query: 837 CSVGRHHTVL-NHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKIS 895
R + + + + K W + S+++A+ S+ + +K
Sbjct: 677 EEERREQELAEEEQEQARERIKSRIPKWQW----QLESEADARQSK-----VYSRPRKQE 727
Query: 896 PTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYF--------HDKNAKKPTFQK 947
++Q+E +S+ Q +E + + + + F + ++ +
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 948 KNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQ--QQNSVLQNAKKTA 1005
+ Q+ R RE+ ++ RER LQ ++ LQ ++
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847
Query: 1006 ELSVKE--YKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLES--S 1061
+L +E +E E+ Q+Q DQ+++ + +K + ++ L+K +
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907
Query: 1062 SEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQL--QYKLKNATNELTKQSSNVKTLK 1119
E L E + + Q + E +QL + + K E +Q K L+
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 1120 FELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVK 1179
+ +E+ + E EK R ER + K+R++ L+ + ++L+ +++ K
Sbjct: 968 QK---EEQLLGEEPEKRRRQER----------EKKYREEEELQQEE--EQLLR--EEREK 1010
Query: 1180 TLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETES 1239
+E + D L+Q ++E+ + ++ ++ ++ E+++L+ E E
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ--------QEEEQ 1062
Query: 1240 AMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKAL--AKELQNDVHV 1297
+ E +Q E + E+ L+ ++ LL + + +ELQ +
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 1298 VRRQIRELKKM----KKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTK 1353
+ R+ RE ++ ++ R+ + + Q L R +LE E++++ E+ +
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 1354 IDAENDKE 1361
+ E ++
Sbjct: 1183 LLREEQEK 1190
Score = 92.4 bits (228), Expect = 3e-18
Identities = 227/1281 (17%), Positives = 511/1281 (39%), Gaps = 142/1281 (11%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKR---LQVTNPDLTQVVSLVVEREKQKSEAKDRKV 162
EEE K E L + +++ +R LQ L ++ + RE+Q+ E + +++
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 163 LEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEI 222
Q++ + QE E+RE ++E + +R+ +E R+E ++ + + Q++
Sbjct: 301 RREQQLR--RKQEEERREQ--QEERREQQERREQQEE-----RREQQLRREQEERREQQL 351
Query: 223 KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKI 282
+ +E + +E+Q R + EEE ++ R L ++LR+++ R+++ + ++
Sbjct: 352 RREQE-EERREQQLR---REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 283 KTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNS 342
+ + + R+E ++ + + + + + Q+ + L R++ + L ++
Sbjct: 408 RREQ----QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 343 THTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLR 402
T +Q QQL+ R+QE+ + ++ E + E LR
Sbjct: 464 TERHEQERRKQQLK----------RDQEEERRERWLKLEEEERR-----EQQERREQQLR 508
Query: 403 QSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMV 462
+ ++Q L++++E +L+++L+ Q L QE + + L
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQ--QLRREQEERREQLLKREEEKRLEQERREQR 566
Query: 463 SQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSF 522
++ + E + LK E+ + + + + + E + E +R + L K
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL--KREE 624
Query: 523 TDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERL---------------Q 567
+ E Q+L K+E + E ++ L+ + QE E R E+ +ERL +
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Query: 568 MLQTNYRAVKEQLK------QWE-EGSGMTEIRKI----KRADPQQLRQEDSDAVWNELA 616
+ + +E++K QW+ E K+ ++ + Q+ RQE + +
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 617 YFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVA-----ERREEQLFRSGED 671
+ + +E ++ EE+ + ++ + + R A E+RE QL
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 672 DEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSR-KLKEGNKKLMKENDFLKSLLK 730
+R PE+ K EQ ++ E E L+ E+ + + +E ++L +E D L+ +
Sbjct: 805 QREQRFLPEEEEK---EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 731 QQQEDTETREK----ELEQIIKG-----------SKDVEKENTELQVKISELETEVTSLR 775
+++ + R++ +LE+ K + + KE LQ + EL+ E R
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Query: 776 ------RQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVK 829
RQ E L+ E E+L+ + + +R + K++ + + K
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ-KEEQLLGEEPEK 980
Query: 830 FKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVE 889
+ ++ + +++ E + WE + + + Q ++ E
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ----LLRE 1036
Query: 890 TSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKN 949
+K E + +E + + + Q L + +T + ++ +K ++
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQ-------LLGEERETRRRQELERQYRKEEELQQE 1089
Query: 950 CKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSV 1009
+ R RE+ + LLRE ++Q E
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE---------LERQY 1140
Query: 1010 KEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESS--SEITSL 1067
+E +EV ++ +Q + ++ + RQ +++ + L++E+E LL++ + E
Sbjct: 1141 REEEEVQQE--EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 1068 AEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNE-----LTKQSSNVKTLKFEL 1122
E ++ + + + DL+ Q + + +NA + +++ + L+
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKW-QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ 1257
Query: 1123 LAKEEHIKEMHEKI-SRMERDITMKRHLIE--DLKFRQKVNL--ESNKSFSEMLQNLDKK 1177
L + +++ + + ERD +R + D F ++ L E K + ++
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Query: 1178 VKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISET 1237
+ L EE K+ +Q + +E+ Q Q ++ +++D K R E
Sbjct: 1318 KQLLREEREEKR-----RRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 1238 ESAMAEIETAASKQLQELA-LQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKE-----L 1291
E E +Q +E L+ EQ L ++ L ++ +F + L+++
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432
Query: 1292 QNDVHVVRRQIRELKKMKKNR 1312
+ + VRRQ RE K +++ +
Sbjct: 1433 REEEQQVRRQERERKFLEEEQ 1453
Score = 37.4 bits (85), Expect = 0.10
Identities = 72/401 (17%), Positives = 177/401 (44%), Gaps = 23/401 (5%)
Query: 992 QQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKE- 1050
QQ+ Q ++ +L +E +E E+ L ++Q ++R Q R+ ++ + LR+E
Sbjct: 324 QQERREQQEERREQQLR-REQEERREQQLRREQEEERREQQLRREQEEERREQQ-LRREQ 381
Query: 1051 ---KEDLLKKLESSSEITSLAEENSQVTFPRIQ-VTSLSPSRSMDLEMKQLQYKLKNATN 1106
+E L++ + L E +++ L + + E ++ +++ K+
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 1107 ELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKS 1166
++ + + + L +EE E HE+ R ++ +KR E+ + R + LE +
Sbjct: 442 RREQRLKREQEERRDWLKREEET-ERHEQERRKQQ---LKRDQEEERRERW-LKLEEEER 496
Query: 1167 FSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLK 1226
E + +++++ EE +++ ++RL ++ + Q + ++ +E+L K++ +
Sbjct: 497 -REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 1227 LTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKA 1286
L R + E E + L+ + +Q L+ Q+ L K EE V+
Sbjct: 556 KRLEQER--REQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE----VER 609
Query: 1287 LAKELQNDVHVVRRQIRELKKMK----KNRDACKTSTHKAQTLAASILNISRSDLEEILD 1342
L +E + + + R + E ++ + + ++ + + + + R + EE L+
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 1343 TEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEA 1383
+ E E+ + + E +E ++ ++ ++P + LE+
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 128 bits (322), Expect = 3e-29
Identities = 273/1373 (19%), Positives = 550/1373 (40%), Gaps = 201/1373 (14%)
Query: 87 RRLEGISVE-EAMVTRTQLLEEELSSLKE----ELALCQADKEFVWSLWKRLQVTNPDLT 141
R+L+ + + ++ R LEEEL++LK+ E+ L + ++ V + + + +T
Sbjct: 993 RKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVT 1052
Query: 142 ---QVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFE----QRESVLKQEINDLVKRK 194
Q + + +++ + E + + + + L+ K A ++F+ Q L+ + N + +
Sbjct: 1053 SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQ 1112
Query: 195 IAVDEENAFLRKEF-SDLEKKFKDKSQEIKDT----KECVQNKE------EQNRLVI-KN 242
+ E A ++K S+ + D +K+T C + E E+ L + K
Sbjct: 1113 AEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKE 1172
Query: 243 LEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSK 302
E+ KKL T L+K +++E HLR+E ++ E KE E +
Sbjct: 1173 KEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ 1232
Query: 303 YNALSLQLSNKQTELIQKDMDITLVRKELQEL--------QNLYKQNSTHTAQ---QAEL 351
L +Q +++ +D L + QE + L+K H Q ++ L
Sbjct: 1233 LRQLQIQ--------VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
Query: 352 IQQLQVLNMDTQKVLRNQEDVH---TAESISYQKLYNELHICFETTKSNEAMLRQSVTNL 408
+ D + + I +K+ EL + +T S + V L
Sbjct: 1285 CPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV--ELELKVSSTTSELTKKSEEVFQL 1342
Query: 409 QDQLLQKEQENAKLKEKLQESQGAPLPLPQ--ESDPDYSAQVPH----RPSLSSLETLMV 462
Q+Q+ ++ E LK E++ L Q ES A + H +P L L+ L+
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402
Query: 463 SQKSEIEYLQEKL---KIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPK 519
++ ++ YL +L + A K+ I + K++ T E + KE
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI-KALHTQLEMQAKE------------ 1449
Query: 520 SSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQ 579
+ +I+ L+ L Q+ +E+ + +++ + LQ + KE
Sbjct: 1450 --------------HDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495
Query: 580 LKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDEL 639
LK E + E + R ++L + +D V ++++ +E ++ + L+EE D+L
Sbjct: 1496 LK---ENKSLQEELSLARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLALLQEERDKL 1551
Query: 640 KVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELEN 699
I E++R + E + S + +K + + + E + V E+E+
Sbjct: 1552 ----------ITEMDRSLLENQS----LSSSCESLKLAL-----EGLTEDKEKLVKEIES 1592
Query: 700 RLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTE 759
S S + +E +K+L KE + +L Q E+ + ++ +++ V +E E
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYE----ILLQSYENVSNEAERIQHVVEA---VRQEKQE 1645
Query: 760 LQVKISELETEVTSLRRQVAEANALRNENEELINPMEKS-------------------HQ 800
L K+ E +Q+ EA E +E + KS H
Sbjct: 1646 LYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHP 1705
Query: 801 SADRAKSEMATMKVRSGRYDCKTTMTKVKFK---AAKKNCSVGRHHTVLNHSIKVMSNVF 857
+ D AK M T+ S K + +VK + +KK S+ L+ ++ + +
Sbjct: 1706 AGDTAKECMETL--LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 858 E-NLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKIS------PT--EDGKDQKESDP 908
E N+SK + +E + T + +I ET ++ S PT E K ++P
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 909 TEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREK 968
+ + YL D ++ A ++KN + ++ T +++
Sbjct: 1824 AVSKDFSSHDEINNYLQ-----QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
Query: 969 YKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQ------ 1022
K+ + + + +Q++ S + K+TAE +E ++ E+L++Q
Sbjct: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE---EEKDDLEERLMNQLAELNG 1935
Query: 1023 ------QQVSDQRFQTS--RQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQV 1074
Q V+D + + +K L ++ L +EK+ L+K E T + E +
Sbjct: 1936 SIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK------EKTKVESEIRKE 1989
Query: 1075 TFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHE 1134
+IQ P K+LQ LK E+ + + + ++ A E +K +
Sbjct: 1990 YLEKIQGAQKEPGNKS--HAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047
Query: 1135 KISRMERDITM-KRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSID 1193
+ ++D+ + K +L + ++ R+K E SF +L + + + + K +
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHRKKAQAEL-ASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
Query: 1194 SLKQRLNVAVKEKSQ-----YEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAA 1248
S K+ + +K+K + EQ +K +E + KL L E + EI+
Sbjct: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
Query: 1249 SKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKM 1308
+K+ +E+ +Q+ E T V + F K+++ LQ+D R I E KK
Sbjct: 2167 NKKDKEV----QQLQENLDST-------VTQLAAFTKSMS-SLQDDRD---RVIDEAKKW 2211
Query: 1309 KKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKE 1361
++ S + L ++ + L ++ ++++I +++ E+DK+
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL--EHDKQ 2262
Score = 122 bits (307), Expect = 2e-27
Identities = 275/1403 (19%), Positives = 555/1403 (39%), Gaps = 201/1403 (14%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEI 165
E EL ++++L A +E +L K++ T D T + L+ + + +
Sbjct: 1070 EVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSN 1129
Query: 166 LQVKDAKIQEFEQRESVLKQEINDLVKR-KIAVDEENAFLRKEFSDLEKKFKDKSQEIKD 224
D + V+ + K ++E+ L KE L+KK ++ K
Sbjct: 1130 TDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKA 1189
Query: 225 TKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKE-KYSTDAKIK 283
+ Q KE R +K +++ +L + + + E + Q L+ + + S D K+
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLP 1249
Query: 284 T------------FEDNLIEARKEVEVSQSKYNAL-------SLQLSNKQ--TELIQKDM 322
+ E+ L +A ++ + L S S Q T + Q
Sbjct: 1250 STDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKA 1309
Query: 323 DITLVRKELQELQNLYKQNSTHTAQQAELIQQLQV------LNMDTQKVLRNQEDVHTAE 376
+ + E EL+ ++ +++E + QLQ L +++ K + ++ +VH AE
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVH-AE 1368
Query: 377 SISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPL 436
S+ + ++L I + L+ + LQ + +KE++ + L +L E + A +
Sbjct: 1369 SLQQKLESSQLQIA---GLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 437 PQESDPDYSAQVPHRPSLSSLETLMVSQKSE----IEYLQEKL---KIANEKLSENISAN 489
E + + +L T + Q E I+ LQ +L K E++ E A
Sbjct: 1426 QTEI-------IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK 1478
Query: 490 KGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIE------NLEK 543
+ RK + +A KE +K ++SL + S +++L K+ +E N EK
Sbjct: 1479 QQIQRK--LQAALISRKEA-LKENKSLQEELSLARGT-IERLTKSLADVESQVSAQNKEK 1534
Query: 544 -----ALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRK--IK 596
L L +E D+L ++ Q L ++ ++K L+ G+TE ++ +K
Sbjct: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE------GLTEDKEKLVK 1588
Query: 597 RADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRC 656
+ + + W E ++ E+++Q ++S + IQ +
Sbjct: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYE----------NVSNEAERIQHVVEA 1638
Query: 657 VAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRK----LK 712
V + ++E L+ E + EK L++ Q++ E++ +++ F K ++ L+
Sbjct: 1639 VRQEKQE-LYGKLRSTEANKKETEKQ----LQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693
Query: 713 EGNKKLMKE----NDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELE 768
E N +L E D K ++ + ++ELE++ + + K+ L + L
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753
Query: 769 TEVTSLRRQVAEANALRNENEELI-------NPMEKSHQSADRAKSEMATMKVRSGRYDC 821
EV L+ Q+ E N + N E N E+ QS E ++ + S R C
Sbjct: 1754 EEVQDLKHQI-EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM-STRPTC 1811
Query: 822 KTTMTKVKFKAAKKNCSVGRHHTVLNH-------------------SIKVMSNVFEN--- 859
++ K + H + N+ K S EN
Sbjct: 1812 SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN 1871
Query: 860 --LSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGK 917
LS+ +D E L I E +++ ++ ++++ D E Q
Sbjct: 1872 TLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLA 1931
Query: 918 EIVQTYLNI-----DGKTPKDYFHD--KNAKKPTFQKKNCKMQK-SSHTAVPTRVNREKY 969
E+ + N D + + KN KK + + K Q T V + + +E
Sbjct: 1932 ELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
Query: 970 KNIT-AQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQ 1028
+ I AQK N +E LQ K + VK+ ++ + + +Q+++S
Sbjct: 1992 EKIQGAQKEPGNKSHAKE-----------LQELLKEKQQEVKQLQK--DCIRYQEKIS-- 2036
Query: 1029 RFQTSRQTIKKLNLDLAGLRKE----KEDLLKKLE----SSSEITSLAE--ENSQVTFPR 1078
+T+K L +K+ KE+L + +E + +E+ S +++Q R
Sbjct: 2037 ---ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAAR 2093
Query: 1079 IQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKE---MHEK 1135
+ +L + + + ++ ++K +L ++ A+E+H+KE M EK
Sbjct: 2094 VLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ---------AEEKHLKEKKNMQEK 2144
Query: 1136 ISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSL 1195
+ + R+ K HL E + Q + +K ++ +NLD V L + D
Sbjct: 2145 LDALRRE---KVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDR 2201
Query: 1196 KQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQEL 1255
+ ++ A K + ++ Q +EE+ K+ ++L ++ + M E++ S+ +
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD- 2260
Query: 1256 ALQSEQVLEGAQKTLLLANEKV-EEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDA 1314
+Q+ E +T + +KV + K L +L+ H+ EL K++
Sbjct: 2261 ----KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES---- 2312
Query: 1315 CKTSTHKAQTLAASILNISRSDLEEILDTEDQVE--IEKTKIDAENDKEWMLYIQKLLEG 1372
+ ++L + ++S S LE+ + + +E I + + D +N K + + LE
Sbjct: 2313 ------ELKSLKDQLTDLSNS-LEKCKEQKGNLEGIIRQQEADIQNSK----FSYEQLET 2361
Query: 1373 QLPFASYLLEAVLEKINEKKKLV 1395
L + L + E+IN K++ +
Sbjct: 2362 DLQASRELTSRLHEEINMKEQKI 2384
Score = 119 bits (299), Expect = 2e-26
Identities = 250/1395 (17%), Positives = 543/1395 (38%), Gaps = 184/1395 (13%)
Query: 99 VTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAK 158
V + Q E S EE++L A E L+ T D + +S V + + +
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVE--------LKSTKQDGDKSLSAVPDIGQCHQDEL 686
Query: 159 DRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDK 218
+R +IL+++ F + + + ++ +++ K +++ +K + F
Sbjct: 687 ERLKSQILELE----LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742
Query: 219 SQE-------IKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHL 271
S+E +K+ + + + +L + E E ++ + +D L +Q L
Sbjct: 743 SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSL 801
Query: 272 RKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKEL 331
E S D KI+ ++ L + + + + +L QL NK++E+++ + + ++
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 332 QELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICF 391
+EL Q ++L++ MD Q +L + DV T + +K I F
Sbjct: 862 EELSQALSQ------------KELEITKMD-QLLLEKKRDVETLQQTIEEKDQQVTEISF 908
Query: 392 ETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHR 451
T + + L ++ E LKE+L A ++ + D +
Sbjct: 909 SMT--------EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
Query: 452 PSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVK 511
+ + K E+++ + LK NE+ + A
Sbjct: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQA----------------------- 997
Query: 512 RSRSLSPKSSFTDSEELQKLRKAERKIENL----EKALQLKSQENDELRDAHEKRKERLQ 567
+ E LQ++ + E ++ NL +K + L E E+ + E ++ +
Sbjct: 998 --------ALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEK 1049
Query: 568 MLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMI 627
+ + + ++ LKQ E++ I++ ++L E+ A K+ NQ L
Sbjct: 1050 CVTSKCQEIEIYLKQ-TISEKEVELQHIRKDLEEKLAAEEQFQ-----ALVKQMNQTLQ- 1102
Query: 628 QKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEML 687
K N ++D L+ IS ++A IQ+L + + ++ V + +
Sbjct: 1103 DKTN---QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWK 1159
Query: 688 EQTLQKVTELENRLKSFEKRSRKLKEGNKKLMK----ENDFLKSLLKQQQEDTETREKEL 743
+ +K+ LE + +K+ ++ K ++K + L+ LKQQ++D +++
Sbjct: 1160 PELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQF 1219
Query: 744 EQIIKGSKDVEKENTELQVKISE-LETEVTSLRRQVA-------EANALRNENEELINPM 795
++ K ++++ + +LQ+++ E ++ ++ S +Q + E + + P+
Sbjct: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
Query: 796 EKSHQSADRAKSEMATMKVRSGR--YDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVM 853
+S+ D ++ G K + +++ + + V + L + +
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339
Query: 854 SNVFENLSKDGWEDVSESSSDSEAQT----------SQTLGTIIVETSQKISPTEDGKDQ 903
+ E ++K G E S + EA+ S L +E +++ P D +
Sbjct: 1340 FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQK 1399
Query: 904 KESDPTED-----SQTQGKEIVQTYLNIDGKTPKDYF-------------HDKNAKKPTF 945
S ED Q KE T + + +D HD+ K+
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ--L 1457
Query: 946 QKKNCKM-QKSSHTAVPTRVNREKYKNITAQKSS-------------------SNIILLR 985
Q + C+M QK +R ++ + + A S I L
Sbjct: 1458 QVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517
Query: 986 ERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLA 1045
+ + ++ Q S K T + +E +KL+ + S Q+ + + L L L
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE 1577
Query: 1046 GLRKEKEDLLKKLES--SSEITSLAE-ENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLK 1102
GL ++KE L+K++ES SS+I E + + L ++ E +++Q+ ++
Sbjct: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE 1637
Query: 1103 NATNE-------LTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKF 1155
E L +N K + +L E+ ++EM EK+ + + K +E+
Sbjct: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
Query: 1156 RQKVNLE-SNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
R + + + + E ++ L ++ EE K+ ++L ++ + EK + Q
Sbjct: 1698 RLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQ 1757
Query: 1215 KSKEELEKKDLK-LTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLA 1273
K ++E K L + + ++ + E T Q + ++E+ + T
Sbjct: 1758 DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT------QSIPGETEEQDSLSMSTRPTC 1811
Query: 1274 NEKVEEFTTFVKALAKEL--QNDVHVVRRQIRELK--------KMKKNRDACKTSTHKAQ 1323
+E V + A++K+ ++++ +QI +LK + +KN++ +T ++
Sbjct: 1812 SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN 1871
Query: 1324 TLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEA 1383
TL + I + +L+ + Q E+ K + + +E + + KL E L E
Sbjct: 1872 TLLSQI-STKDGELKML-----QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
Query: 1384 VLEKINEKKKLVEGY 1398
++ ++ E + Y
Sbjct: 1926 LMNQLAELNGSIGNY 1940
Score = 118 bits (296), Expect = 3e-26
Identities = 256/1350 (18%), Positives = 558/1350 (41%), Gaps = 215/1350 (15%)
Query: 102 TQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNP----DLTQVVSLVVEREKQKSEA 157
+Q LE E ++L +++ + + + ++ + N +L++V L E++K +
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL 1922
Query: 158 KDRKVLEILQ-----------VKDAKIQ----EFEQRE-----SVLKQEINDLVKRKIAV 197
++R + ++ + V DA+I+ E E + S L++E LVK K V
Sbjct: 1923 EERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV 1982
Query: 198 DEENAFLRKEF-----------------SDLEKKFKDKSQEIKDT-KECVQNKEEQNRL- 238
+ E +RKE+ +L++ K+K QE+K K+C++ +E+ + L
Sbjct: 1983 ESE---IRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALE 2039
Query: 239 -VIKNLE----EENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTD----AKIKTFEDNL 289
+K LE E K L +L +E +K +A L K D + DNL
Sbjct: 2040 RTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNL 2099
Query: 290 -----IEARKEVEVSQSKYNALSLQLSNKQTEL--------IQKDMD------------- 323
+++ KE SQ K L+ +Q E +Q+ +D
Sbjct: 2100 KLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159
Query: 324 ----ITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESIS 379
+TL +K+ +E+Q L + + Q A + + L D +V+ + S +
Sbjct: 2160 GEIQVTLNKKD-KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDA 2218
Query: 380 YQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQ-------------KEQENAKLKEKL 426
Q E+ + + + LRQ ++++ + K Q +L++K+
Sbjct: 2219 IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV 2278
Query: 427 QES-QGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANE----- 480
++ QG L + + + L+ LE+ + S K ++ L L+ E
Sbjct: 2279 CDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338
Query: 481 ----KLSENISANKGFSRKSIMTSAEGK-------HKEPPVKRSRSLSPKSSFTDSEE-- 527
+ E N FS + + T + H+E +K + +S S ++ +
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Query: 528 LQKLRKA-ERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVK-EQLKQWEE 585
+ +LR+ +++I+ LE L + +EN L + ++K ++ L + +K E ++Q +
Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458
Query: 586 GSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEEL----DELKV 641
+ Q D D + + + + ++++K L +E ++LK
Sbjct: 2459 LDSFVK--------SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE 2510
Query: 642 HISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRL 701
I ++ + +LN A + + +L + ED + + K++LE LQ+ ELEN+
Sbjct: 2511 EIRGLRSHMDDLNSENA-KLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKY 2569
Query: 702 KSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENT--- 758
E++ ++ +E N+ L + + L+ + ++ E+ + + Q+ + +++E T
Sbjct: 2570 AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGL 2629
Query: 759 ---ELQVK-----------------ISELETEVTSLRRQVAE-----ANALRNENEELIN 793
+L+VK I+ELE E+ ++++ A+ + L+ E + L +
Sbjct: 2630 YHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689
Query: 794 PMEKSHQSADRAKSEMATMKVRSGRYDCKTTM-TKVKFKAAKKNCSVGRHHTVLNHSIKV 852
+ A+ +A + + K M TK + S GR + L +S
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
Query: 853 MSNVFENLSKDGWEDVSE-SSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTED 911
+ + L + + E + + ++ ++ ET+ ++ TE E+
Sbjct: 2750 ANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTE-----------EN 2798
Query: 912 SQTQGKEIVQTYLNIDGKT--PKDYFHDKNAKKPTFQKKNCKMQKSS----HTAVPTRVN 965
S + +++ Q L+ D + D + +F K +Q + R +
Sbjct: 2799 SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS 2858
Query: 966 REKYKNITAQKSSS--NIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKL---- 1019
E + AQ S+S + L++ + SLQ L K + ++Y ++N+++
Sbjct: 2859 EEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ---QQYLQINQEITELH 2915
Query: 1020 -----LHQQQVSDQRFQTSRQTIKKLNL----DLAGLRKEKE--DLLKKLESSSEITSLA 1068
L + Q + FQ ++ +++ NL +L LR EK ++ ++ + +++
Sbjct: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975
Query: 1069 EENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKF--ELLAKE 1126
+++ Q++ + + L S S +K +QY+ + A+ E + + L + ELL +
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLK-VQYQ-RQASPETSASPDGSQNLVYETELLRTQ 3033
Query: 1127 --EHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEE 1184
+ +KE+H+K R+++ + L+E+ ++++S E Q+ L
Sbjct: 3034 LNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG----DLLNH 3089
Query: 1185 CSNKKVSIDSLKQ---RLNVAVKEKSQYEQMYQKS-KEELEKKDLKLTLLVSRISETESA 1240
C+ + + L+ ++VA + +++KS EEL + + ++ T
Sbjct: 3090 CAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQE 3149
Query: 1241 MAEIETAASKQLQELALQSEQVLEGAQKTL 1270
+ E+ ++ ++ + +E L A++ +
Sbjct: 3150 VNELRKLLEEE-RDQRVAAENALSVAEEQI 3178
Score = 115 bits (287), Expect = 4e-25
Identities = 217/1087 (19%), Positives = 451/1087 (41%), Gaps = 173/1087 (15%)
Query: 392 ETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHR 451
E + A Q V L+D + QK+ + + E LQE + A + ++ +
Sbjct: 48 EDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKA------ADNKIKKLKLHAK 101
Query: 452 PSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHK----- 506
L+SL + K++ + + E+LS++ + S + M + KHK
Sbjct: 102 AKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKS----STEEEMEIEKIKHKLQEKE 157
Query: 507 ------EPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHE 560
+ + ++++ P S T+ EE +++ ++ E LQ + + + A +
Sbjct: 158 ELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQ 217
Query: 561 KRKERLQMLQTNYRAVKEQLKQW-EEGSGMTEIRKIKRADPQQLRQEDS---------DA 610
+E+ +T R +++L Q + TE+++ R ++L + + D
Sbjct: 218 VVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDL 277
Query: 611 VWNELAYFKRENQELMIQKMNLEEELDELKVHISID----KAAIQELNRCVAERR----- 661
+ EL ++ NQ L Q +E E + L+ + + K ++++ VAER+
Sbjct: 278 LQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHN 337
Query: 662 --------EEQLFRSGE---DDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRK 710
EQ ++G+ + E + S E+ K +E+ + L+ + +
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA 397
Query: 711 LKEGNKKLMKEND----FLKSLLKQQQEDTETREKELEQII------------------- 747
LK+ N KL+++ + ++Q ++ + + KE+ Q +
Sbjct: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDV 457
Query: 748 --KGSKDVEKEN-TELQVKISELETEVTSLRRQVAEANALRNENEEL---INPMEKSHQS 801
+G++ V +EN LQ ++ ELE E +L E L+ ENE+L I +E +++
Sbjct: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
Query: 802 --ADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFEN 859
ADR SE++ + + + R ++ + + +N + + H L+ + M E
Sbjct: 518 GEADREVSEISIVDIANKR----SSSAEESGQDVLEN-TFSQKHKELSVLLLEMKEAQEE 572
Query: 860 LS--KDGWEDVSESSSDSEA----QTSQTLGTIIVETSQKISPTEDGKD----------- 902
++ K + +D E + Q G I K+ + G+D
Sbjct: 573 IAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL 632
Query: 903 ---QKESDPTEDSQTQGKEIVQTYLNIDGK-TPKDYFHDKNAKKPTFQKKNCKMQKSSHT 958
+KE TE +EI ++ K T +D +A Q ++++
Sbjct: 633 PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692
Query: 959 AVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEY---KEV 1015
+ +N K + I + L E+ + N +++ KK A+ + + E
Sbjct: 693 ILELELNFHKAQEIYEKN-------LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE 745
Query: 1016 NEKLLHQQQVSDQRFQTS-RQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQV 1074
++LL QV + T R +K+L ++LA +++ ES + +L E
Sbjct: 746 RDQLL--SQVKELSMVTELRAQVKQLEMNLAEAERQRR---LDYESQTAHDNLLTE---- 796
Query: 1075 TFPRIQVTSLS-PSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEH----- 1128
Q+ SLS ++S D++++ LQ +L + + ++QS+ +++L+ +L KE
Sbjct: 797 -----QIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGA 851
Query: 1129 ---------IKEMHEKISRMERDITMKRHLI----EDLKFRQKVNLESNKSFSEMLQNLD 1175
++E+ + +S+ E +IT L+ D++ Q+ E ++ +E+ ++
Sbjct: 852 ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 1176 KKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRIS 1235
+K+ L EE + V I +LK++LN+ + + + KE++E+ + + L
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAE-------EAKKEQVEEDNEVSSGLKQNYD 964
Query: 1236 ETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAK---ELQ 1292
E A + + L ++EQ Q L+ E ++ + + LA E +
Sbjct: 965 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESK 1024
Query: 1293 NDV---HVVRRQIRELKKMKKNRDACKTS------THKAQTLAASILNIS--RSDLEEIL 1341
++ R ++ E K+ K+ + C TS + QT++ + + R DLEE L
Sbjct: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 1342 DTEDQVE 1348
E+Q +
Sbjct: 1085 AAEEQFQ 1091
Score = 99.8 bits (247), Expect = 2e-20
Identities = 246/1254 (19%), Positives = 509/1254 (40%), Gaps = 220/1254 (17%)
Query: 149 EREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEF 208
E +++ +A D K+ ++ AK+ + +K + ++ + +E+ + K
Sbjct: 80 EALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSS 139
Query: 209 SDLE---KKFKDKSQEIKD-------------TKECVQNKEEQNRLVI--KNLEEENKKL 250
++ E +K K K QE ++ ++ Q+ E V+ + L+E+ + +
Sbjct: 140 TEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFI 199
Query: 251 STRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVS---QSKYNALS 307
ST L + Q+ +R++ + +++ ED L++ + +V Q K L
Sbjct: 200 STLQAQLSQTQAEQAAQQV-VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ 258
Query: 308 LQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELI-QQLQVLNMDTQKVL 366
+L + L+ + + L+++EL T Q+ +++ QQLQ + + L
Sbjct: 259 RKLEEHEESLVGRAQVVDLLQQEL-----------TAAEQRNQILSQQLQQMEAE-HNTL 306
Query: 367 RNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQ---LLQKEQENAKLK 423
RN + ES I E + A + S NLQ++ LL++ ++ + +
Sbjct: 307 RNTVETEREES----------KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
Query: 424 EKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLS 483
+L+ A L Q+ + + H SL E++ + LK N KL
Sbjct: 357 AELESRYSA---LEQKHKAEMEEKTSHILSLQKTG-------QELQSACDALKDQNSKLL 406
Query: 484 ENISANKGFSRKSIMT---SAEGKHKEP-------PVKRSRSLSPKSSFTD--------- 524
++ + S ++I + K KE P+++ + S ++SF D
Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETAS-QTSFPDVYNEGTQAV 465
Query: 525 -SEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQW 583
E + L+K ++EN + AL L S E +EL+ +EK ++ +L+ Q +
Sbjct: 466 TEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEA-------QNRTG 518
Query: 584 EEGSGMTEIRKIKRADPQQLRQEDS--DAVWNELAYFKRENQELMIQKMNLEEELDELKV 641
E ++EI + A+ + E+S D + N + +E L+++ +EE+ LK+
Sbjct: 519 EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL 578
Query: 642 HISIDKAAIQELNRCVAERRE-EQLFRSGEDDEVKRSTPEKNGKE--MLEQTLQKVTELE 698
+ +A +E + V +++E +Q+ G + E G++ ++ + +E
Sbjct: 579 QLQGKRA--EEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVE 636
Query: 699 NRLKSFEKRSRKLKE------GNKKLMKENDFLKSL-----LKQQQEDTETREKELEQII 747
S E +SR +E G + + D KSL + Q +D R K QI+
Sbjct: 637 KEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLK--SQIL 694
Query: 748 KGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPM-EKSHQSADRAK 806
+ + K + + E E+++L + + E + N + E+ Q + K
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754
Query: 807 SEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWE 866
++R+ + + + + + S H +L I +S E SKD
Sbjct: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLS--IEAKSKDVKI 812
Query: 867 DVSESS-SDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLN 925
+V ++ D + Q S E S I + KES+ E G E V+
Sbjct: 813 EVLQNELDDVQLQFS--------EQSTLIRSLQSQLQNKESEVLE-----GAERVR---- 855
Query: 926 IDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLR 985
SS ++ +K IT ++L +
Sbjct: 856 ---------------------------HISSKVEELSQALSQKELEIT---KMDQLLLEK 885
Query: 986 ERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLA 1045
+R + QQ ++ + ++ E+S + EK++ Q+++++F + IK L L
Sbjct: 886 KRDVETLQQ-TIEEKDQQVTEISF----SMTEKMV---QLNEEKFSLGVE-IKTLKEQLN 936
Query: 1046 GLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNAT 1105
L + +E +++E +E++S ++N +SP+ + E Q ++ L
Sbjct: 937 LLSRAEEAKKEQVEEDNEVSSGLKQN---------YDEMSPAGQISKEELQHEFDLLKKE 987
Query: 1106 NELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNK 1165
NE K+ +L A + KE+ +++SR+E ++ +L ++ K ++
Sbjct: 988 NEQRKR---------KLQAALINRKELLQRVSRLEEELA---NLKDESKKEIPLSETERG 1035
Query: 1166 SFSEMLQNLDKKVKTLTEEC-----------SNKKVSIDSLKQRLNVAVKEKSQYEQMYQ 1214
E +N + K +T +C S K+V + +++ L + + Q++ + +
Sbjct: 1036 EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVK 1095
Query: 1215 KSKEELEKKDLKLTLLVSRISETESAMAEIETA--ASKQLQELALQSEQVL--------- 1263
+ + L+ K ++ LL + ISE ++ + ++ T+ + +AL E V+
Sbjct: 1096 QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSS 1155
Query: 1264 -----EGAQKTLLLANE------KVEEFTTFVKALAKELQNDVHVVRRQIRELK 1306
E +K L L E K++E T KA+ K+ Q +R ++++ K
Sbjct: 1156 EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQK 1209
Score = 69.7 bits (169), Expect = 2e-11
Identities = 95/450 (21%), Positives = 193/450 (42%), Gaps = 42/450 (9%)
Query: 927 DGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRE 986
D K K H K AK + K +M+ T +PT E+ + + S+ + + +
Sbjct: 90 DNKIKKLKLHAK-AKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEK 148
Query: 987 RIISLQQQNSVL-----QNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLN 1041
LQ++ ++ Q + AE + E+ E ++ +QQ+ Q + I L
Sbjct: 149 IKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL-----QEKEEFISTLQ 203
Query: 1042 LDLAGLRKEK--EDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQY 1099
L+ + E+ + ++++ ++ E E+ + VT M +++ LQ
Sbjct: 204 AQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL----VTQADVETEMQQKLRVLQR 259
Query: 1100 KLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKV 1159
KL+ L ++ V L+ EL A E+ + + +++ +ME + R+ +E + K+
Sbjct: 260 KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI 319
Query: 1160 NLESNKSFSEMLQNLDKKVK--TLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSK 1217
LE + L+ ++K+ L EE + ++ +Q + +S+Y + QK K
Sbjct: 320 LLEKME-----LEVAERKLSFHNLQEEMHHL---LEQFEQAGQAQAELESRYSALEQKHK 371
Query: 1218 EELEKKDLKLTLLVSRISETESAMAEIETAASKQLQ---ELALQSEQVLEGAQKTLLLAN 1274
E+E+K + L E +SA ++ SK LQ E A+QS Q ++ + L +
Sbjct: 372 AEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKS 431
Query: 1275 EKVEEFTTFVKALAKELQN-----DVHVVRRQ-IRELKKMKKNRDACKTSTHKAQTLAAS 1328
+++ +F + E + DV+ Q + E + + K L +S
Sbjct: 432 KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSS 491
Query: 1329 ILNISRSDLEEILDTEDQVEIEKTKIDAEN 1358
I +LEE+ +++ + T ++A+N
Sbjct: 492 I------ELEELKAENEKLSSQITLLEAQN 515
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 126 bits (317), Expect = 1e-28
Identities = 289/1373 (21%), Positives = 574/1373 (41%), Gaps = 214/1373 (15%)
Query: 108 ELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVERE--KQKSEAKDRKVL-- 163
++ + + ELAL + +K ++ + N T+V+ L E E +Q + +D + L
Sbjct: 60 KMKAQEVELALEEVEKAGE----EQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRN 115
Query: 164 EILQVK---DAKIQEFEQRESVLKQE--IND-LVKRKIAVDEENAFLRKEFSDLEKKFKD 217
EI Q++ + K +E E E L++E +N+ L R + EN+ LR+E L+KK +
Sbjct: 116 EICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQ 175
Query: 218 KSQEIKDTKECVQNKEEQNRLVIKNLEEEN--KKLSTRCTDLLNDLEKLRKQEAHLRKEK 275
Q+I D ++ + +++E L+ + E+ + +LS + +L+ L++++ L +
Sbjct: 176 LCQDIIDYQKQIDSQKE--TLLSRRGEDSDYRSQLSKKNYELIQYLDEIQT----LTEAN 229
Query: 276 YSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQ 335
+ + + NL E+ +E+E +YN + + + Q + + ++QEL
Sbjct: 230 EKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELT 289
Query: 336 NLYKQNSTH-----TAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHIC 390
+L K + A A++ + +L+ +++ Q+ +H +KL N
Sbjct: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR----EKLKNAQ--- 342
Query: 391 FETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPH 450
+ KSN L+Q + Q+ ++ + ++++++ L E + A
Sbjct: 343 LDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGA---- 398
Query: 451 RPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPV 510
S S +T M Q S ++ L+EK K A E+ +E A+ A K KE
Sbjct: 399 --STLSQQTHMKIQ-STLDILKEKTKEA-ERTAELAEAD-----------AREKDKELVE 443
Query: 511 KRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQ 570
R +S + L A +I+N + ++++ +E + L K + ++
Sbjct: 444 ALKRLKDYESG------VYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFL 497
Query: 571 TNYRAVKEQL-KQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQK 629
A++E++ + + +TE R K QQ ++ ENQ L+ +
Sbjct: 498 DENEALRERVGLEPKTMIDLTEFRNSKHLKQQQ---------------YRAENQILLKEI 542
Query: 630 MNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQ 689
+LEEE +LK I R +A+ R ++ SG E T + + + +
Sbjct: 543 ESLEEERLDLKKKI-----------RQMAQERGKRSATSGLTTEDLNLTENISQGDRISE 591
Query: 690 TLQKVTELENRLKSFEKR---SRKLKEGNKKLMKENDFL---KSLLKQQQEDTETREKEL 743
+ L+N ++ K SR+L E + L + + ++ LK+ E+ + E+ +
Sbjct: 592 RKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGM 651
Query: 744 EQIIKGSKDVEKE----NTELQVKISELETEVTSLRRQVAE------------ANALRNE 787
++I++ K+++K+ E + I LE V ++ + AE + L
Sbjct: 652 KEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGR 711
Query: 788 NEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTM------TKVKFK--------AA 833
NEEL + +S + A ++A ++ + +T++ + V FK A
Sbjct: 712 NEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAP 771
Query: 834 KKNCSVGRHHTVLNHSIKVMSNVFENLS--KDGWEDVSESSSDSEAQTSQTLGTIIVETS 891
+ + L H ++ + N + L +D ED + + Q S + E
Sbjct: 772 SSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSE-- 829
Query: 892 QKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDK-----NAKKPTFQ 946
++ TE ++E ED Q V+ Y N+ D K N++K T
Sbjct: 830 KETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVL 889
Query: 947 KKNCKMQKSSHTAV-----PTRVNREKYKN--ITAQKSSSNIILLRER-----IISLQQQ 994
+ N K +T + R EK KN ++ + I +R I +
Sbjct: 890 QVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAAL 949
Query: 995 NSVLQNAKKTAELSV--KEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKE 1052
V+ N+ +EL + K+Y E+ K Q + Q + ++ L + L+++ E
Sbjct: 950 QKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRT-SNLEHLECENISLKEQVE 1008
Query: 1053 DLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQS 1112
+ K+LE + E E+ + Q T L SMD K + +++ S
Sbjct: 1009 SINKELEITKEKLHTIEQAWE------QETKLGNESSMDKAKKSI------TNSDIVSIS 1056
Query: 1113 SNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQ 1172
+ L+ +KE++E+ R E M HL LK ++ N E F+E+ +
Sbjct: 1057 KKITMLE---------MKELNER-QRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTK 1106
Query: 1173 -NLD-KKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLL 1230
NLD +KV+ + D L ++ AV + + + ELEK +++L +
Sbjct: 1107 INLDAQKVEQMLR---------DELADSVSKAVSDADRQRIL------ELEKNEMELKVE 1151
Query: 1231 VSRISE-TESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAK 1289
VS++ E ++ A ++E ++Q ++ +E + LL + +E K+L
Sbjct: 1152 VSKLREISDIARRQVEILNAQQQSR-----DKEVESLRMQLLDYQAQSDE-----KSLIA 1201
Query: 1290 ELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEI 1349
+L H V Q+ E + K ++ T K Q + A L LE+ LD ++Q +
Sbjct: 1202 KLHQ--HNVSLQLSEATALGK----LESITSKLQKMEAYNLR-----LEQKLDEKEQA-L 1249
Query: 1350 EKTKIDAEND----KEWMLYIQKLLEGQLPFASY--LLEAVLEKINEKKKLVE 1396
+++ N ++ + +++ G LP A + +++ N+K K+++
Sbjct: 1250 YYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQ 1302
Score = 125 bits (313), Expect = 4e-28
Identities = 256/1302 (19%), Positives = 556/1302 (42%), Gaps = 135/1302 (10%)
Query: 96 EAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKS 155
E + + Q ++E+ SL+ +L QA + SL +L N L Q S
Sbjct: 1167 EILNAQQQSRDKEVESLRMQLLDYQAQSDEK-SLIAKLHQHNVSL------------QLS 1213
Query: 156 EAKDRKVLEILQVKDAKIQEFEQR-ESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKK 214
EA LE + K K++ + R E L ++ L ++ LR+ L ++
Sbjct: 1214 EATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQ 1273
Query: 215 FKDK---SQEIKDTKECVQNKEEQNRLV--IKNLEEENKKLSTRCTDLLNDLEKLRKQEA 269
F +Q+ K +K +Q + ++ +++ +KN ++E++ + + ++ L+ L + +
Sbjct: 1274 FSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIS 1333
Query: 270 HLRKEKYSTDA-----KIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDI 324
L+ K + KI+ ++ +E+ + + L+ +S + + + +I
Sbjct: 1334 TLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEI 1393
Query: 325 TLVRKELQELQNLYKQNSTHTAQQAELI--QQLQVLNMDTQKVLRNQEDVHTAESISYQK 382
K +E Q + Q +Q ++ QQ ++LN QK E+ +
Sbjct: 1394 VQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNA-AQKF----EEATGSIPDPSLP 1448
Query: 383 LYNELHICFETTKSNEAML---RQSVTNLQDQLLQKE------QENAKLKEKLQESQGAP 433
L N+L I K N ++ R + +L+++L +KE ++N ++K+
Sbjct: 1449 LPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLR 1508
Query: 434 LPLPQESDP--------------DYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIAN 479
LP E + ++ ++ H+ ++++++ + ++ ++ Q L+ A
Sbjct: 1509 LPATAEREKLIAELGRKEMEPKSHHTLKIAHQ-TIANMQARLNQKEEVLKKYQRLLEKAR 1567
Query: 480 EKLSENISANKG-----FSRKSIMT-SAEGKHKEPP---VKRSRSLSPKSSFTDSEELQK 530
E+ E + ++ R + S+ K K+ +K+S + P + + +
Sbjct: 1568 EEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTN-----KHFIR 1622
Query: 531 LRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMT 590
L + E+ + + +L + ++ E+++E ++ + +K QL++ E
Sbjct: 1623 LAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED---- 1678
Query: 591 EIRKIKRADPQQLR------QEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHIS 644
E++K+K A+ + L+ Q++S + +EL K N M ++ LK ++
Sbjct: 1679 EVKKVK-AEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMR--NLVERLKSQLA 1735
Query: 645 IDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVT-ELENRLKS 703
+ + + L+R + E R E + ++ + +T +K ++Q + + T EL+ +++
Sbjct: 1736 LKEKQQKALSRALLELRAEMT--AAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVED 1793
Query: 704 FEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVK 763
+ KLKE K + L L + + ++K +I++ +++++EN EL+ +
Sbjct: 1794 LNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQ 1853
Query: 764 ISELET-----EVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGR 818
I L + +T ++ + E L+ + ++L N +E + D + K R
Sbjct: 1854 IKRLTSGLQGKPLTDNKQSLIEE--LQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIR 1911
Query: 819 YD-CKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEA 877
++ K K++ K G T L + + ++F K+ + +
Sbjct: 1912 WEEGKKWQAKIEGIRNKLKEKEGEVFT-LTKQLNTLKDLFAKADKEKLT-LQRKLKTTGM 1969
Query: 878 QTSQTLGTIIVETSQKISPTEDGKDQKESDPT--EDSQTQGKEIVQTYLNIDGKTPKDYF 935
Q LG +E+ +++ + E+D Q ++ V L++ + ++
Sbjct: 1970 TVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKL 2029
Query: 936 H--DKNAKKPTFQKKNCK-MQKSSHTAVPTRVNREKYKNITAQKSSSNIIL---LRERII 989
H +K K T+ K + ++ H + +E K SS NI L L +
Sbjct: 2030 HALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLK-----LSSENIELKFQLEQANK 2084
Query: 990 SLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQV--SDQRFQTSRQTIKKLNLDLAGL 1047
L + + +++ K+ E KE EV KL H + S + +TI + + +
Sbjct: 2085 DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKV 2144
Query: 1048 RKEKEDLLKK--LESSSEITSLAEENSQVTFPRIQVTS-LSPSRSMDLEMKQLQYKLKNA 1104
++E E L K + +S ++ ++ +EN ++ ++ + L SM E K + A
Sbjct: 2145 QRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIA 2204
Query: 1105 TNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESN 1164
NE ++ +T E L ++ E+ + ++ + T KR + + Q +S
Sbjct: 2205 ENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK 2264
Query: 1165 KSFSEMLQNL-DKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKK 1223
S ++ + + K+K L + + K SI LKQ VKE ++ EQ K E+LE++
Sbjct: 2265 SWKSIVVTRMYETKLKELETDIAKKNQSITDLKQ----LVKEATEREQKVNKYNEDLEQQ 2320
Query: 1224 DLKLTLLVSRISETESAM---AEIETAASKQLQE------LALQSEQVLEGAQKTLLLAN 1274
+K+ V +ETE + ++ A+ QL + +++ + GA+ T+ A+
Sbjct: 2321 -IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD 2379
Query: 1275 ---EKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRD 1313
EK+++ T +K E Q+ ++ +I++LKK +N D
Sbjct: 2380 QLKEKIKDLETQLKMSDLEKQH----LKEEIKKLKKELENFD 2417
Score = 108 bits (269), Expect = 5e-23
Identities = 280/1441 (19%), Positives = 566/1441 (39%), Gaps = 215/1441 (14%)
Query: 106 EEELSSLKEELALCQADKEFVWSLWKRLQVTNPDL----TQVVSLVVEREKQKSEAKDRK 161
+ +L L EE + + + K +Q +PD+ T ++ +ER E+K+ +
Sbjct: 634 QNKLKELVEENKQLEEGMKEILQAIKEMQ-KDPDVKGGETSLIIPSLERLVNAIESKNAE 692
Query: 162 -VLEILQVKDAKIQEFEQRESVLKQEIND-----------LVKRKIAVD---EENAFLRK 206
+ + A++ + R L+QE+ + L K + +D +E + LR+
Sbjct: 693 GIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
Query: 207 -EFSDLEKKFKDKSQEIKDTKECVQNKEEQNRL-VIKNLEEENKKLSTRCTDLLNDLEK- 263
E S++ K D I + + N + + + +++ LE + KKL D L D +
Sbjct: 753 SEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKN-LEDSLEDYNRK 811
Query: 264 ---LRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQK 320
+R Q++ L KE S KT + E ++++E Q + +A+ ++ N +Q
Sbjct: 812 FAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLE-DQVQQDAIKVKEYNNLLNALQM 870
Query: 321 DMDITLVRKELQELQNLYKQNSTHTA----QQAELIQQLQVLNMDTQKVLRNQEDVHTAE 376
D D E++ + +NS + LI+Q L ++ ++ LR + + E
Sbjct: 871 DSD---------EMKKILAENSRKITVLQVNEKSLIRQYTTL-VELERQLRKENEKQKNE 920
Query: 377 SISYQKLYNELHICFETTKSNE----AMLRQSVTN---LQDQLLQKEQEN---AKLKEKL 426
+S + E C + K A L++ V N L + L +Q N AK ++ L
Sbjct: 921 LLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDIL 980
Query: 427 QESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENI 486
Q+ + V +L LE +S K ++E + ++L+I EKL
Sbjct: 981 QKD---------------NMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIE 1025
Query: 487 SANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAE---RKIENLEK 543
A + ++ +S + K S+S K + + +EL + ++AE + E+L
Sbjct: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085
Query: 544 ALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQL 603
+L+ + N EL E + L + + + V++ L+ + AD +
Sbjct: 1086 SLKQMEERNFEL----ETKFAELTKINLDAQKVEQMLRD-------------ELAD--SV 1126
Query: 604 RQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREE 663
+ SDA + ++ EL ++ L E D + + I A Q ++ V R +
Sbjct: 1127 SKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQ 1186
Query: 664 QLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKEND 723
L + DE +S K + + L + T L +L+S + +K++ N +L ++ D
Sbjct: 1187 LLDYQAQSDE--KSLIAKLHQHNVSLQLSEATAL-GKLESITSKLQKMEAYNLRLEQKLD 1243
Query: 724 FLKSLLKQQQEDTETREKELEQIIKGSKD------------------VEKENTELQV--K 763
+ L + + R K L Q I+ + ++ +N +L++ +
Sbjct: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
Query: 764 ISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKT 823
+ + E ++ + E EELI+ ++ + + M ++R
Sbjct: 1304 MKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNR 1363
Query: 824 TMTKVKFKAAKKNCSVGRHHTVLNHSIK--VMSNVFENLSKDGWE----DVSESSSDSEA 877
+ K K + N + + ++ + V N F + W+ D+ +
Sbjct: 1364 ELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDR 1423
Query: 878 QTSQTLGT----------------------------------IIVETSQKISPTEDGKDQ 903
Q ++ L II+ET E+ +
Sbjct: 1424 QQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKE 1483
Query: 904 KESD---PTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTA- 959
KES ++ ++ K I + L + ++ + +K K + ++ + T
Sbjct: 1484 KESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIA 1543
Query: 960 -VPTRVNRE-----KYKNIT--AQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKE 1011
+ R+N++ KY+ + A++ I+ E + + LQ A+ S+ +
Sbjct: 1544 NMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQ-----ADSSLNK 1598
Query: 1012 YKEVNEKLLHQQQVSDQ------RFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEIT 1065
+K+ L+ Q R QT+ + + L+ L + + + + LE EIT
Sbjct: 1599 FKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREIT 1658
Query: 1066 SLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAK 1125
L + + ++Q + + E++ L+Y L + E + LK EL A+
Sbjct: 1659 ELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKE-------SQCLKSELQAQ 1711
Query: 1126 EEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEE- 1184
+E + T R+L+E LK + + + K+ S L L ++ EE
Sbjct: 1712 KE---------ANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEER 1762
Query: 1185 ---CSNKKVSIDSLKQRLNVAVKE-KSQYEQMYQ---KSKEELEKKDLKLTLLVSRISET 1237
+++K + +++Q ++ +E K+Q E + + K KE L+ + L +++
Sbjct: 1763 IISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDL 1822
Query: 1238 ESAMAEIETAASKQLQ----------ELALQSEQVLEGAQKTLLLANEK--VEEFTTFVK 1285
+ + + + A +K L+ EL Q +++ G Q L N++ +EE VK
Sbjct: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
Query: 1286 ALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKA-QTLAASILNISRSDLEEILDTE 1344
L +L+ V V ++ +K+ + + K Q I N + E+
Sbjct: 1883 KLENQLEGKVEEV--DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLT 1940
Query: 1345 DQVEIEKTKIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKKLVEGYFTIMKD 1404
Q+ K + A+ DKE + +KL + L LE E ++L + + D
Sbjct: 1941 KQLNTLK-DLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLEND 1999
Query: 1405 I 1405
I
Sbjct: 2000 I 2000
Score = 106 bits (264), Expect = 2e-22
Identities = 268/1485 (18%), Positives = 586/1485 (39%), Gaps = 233/1485 (15%)
Query: 94 VEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQ 153
V E + R + E E S L+ E KRL+ N L Q + ++ +KQ
Sbjct: 144 VNEQLALRNEEAENENSKLRREN--------------KRLKKKNEQLCQDI---IDYQKQ 186
Query: 154 KSEAKDRKVLEILQVKDAKIQEFEQRESVLK--QEINDLVKRKIAVDEENAFLRKEFSDL 211
K+ + + D + Q ++ +++ EI L + ++ +N +RK +
Sbjct: 187 IDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEES 246
Query: 212 EKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQE--- 268
++ + + E K V + VI L++EN + +L DL K + +E
Sbjct: 247 VQEMEKMTDEYNRMKAIVHQTDN----VIDQLKKENDHYQLQVQEL-TDLLKSKNEEDDP 301
Query: 269 ----AHLRKEKY-----STDAKIKTFED---NLIEARKEVEVSQSKYNALSLQ------- 309
+ + E++ S D +I ++ NL E K ++ K N ++LQ
Sbjct: 302 IMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERD 361
Query: 310 ----LSNKQTELIQKDMDI-TLVRKELQELQNLYKQNSTHTAQQAELIQQ-LQVLNMDTQ 363
+ +Q E K+M+ T + ++L+ K ST + Q IQ L +L T+
Sbjct: 362 SQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTK 421
Query: 364 KVLRNQE---------DVHTAESISYQKLYN-----------ELHICFETTKSNEA---M 400
+ R E D E++ K Y E+ C K + +
Sbjct: 422 EAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEI 481
Query: 401 LRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPS------- 453
L + + L+ ++ EN L+E++ + L + + + Q +R
Sbjct: 482 LTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKE 541
Query: 454 LSSLETLMVSQKSEIEYLQEK---------LKIANEKLSENISANKGFSRKSIMTSAEGK 504
+ SLE + K +I + ++ L + L+ENIS S + + +
Sbjct: 542 IESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLS--- 598
Query: 505 HKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKE 564
+K K+ F E ++K R +LE++ + ++ ++L++ E+ K+
Sbjct: 599 -----LKNMSEAQSKNEFLSRELIEKER-------DLERSRTVIAKFQNKLKELVEENKQ 646
Query: 565 RLQMLQTNYRAVKEQLKQWEEGSGMTE--IRKIKRADPQQLRQEDSDAVWNELAYFKREN 622
+ ++ +A+KE K + G T I ++R + ++++ +++ + K +
Sbjct: 647 LEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERL-VNAIESKNAEGIFDASLHLKAQV 705
Query: 623 QELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAE-RREEQLFRSGEDDEVK-RSTPE 680
+L + L +EL E + + + N + +E L R E V +
Sbjct: 706 DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDL 765
Query: 681 KNG---------KEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQ 731
+G E + + ELEN+ K + L++ N+K L K+
Sbjct: 766 PDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKE 825
Query: 732 QQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEEL 791
+ ET + E + I + + +E + + +K+ E + +L+ E + EN
Sbjct: 826 YLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRK 885
Query: 792 INPMEKSHQSADRAKSEMATM--KVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHS 849
I ++ + +S R + + + ++R K + ++ + +K + R +
Sbjct: 886 ITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFK 945
Query: 850 IKVMSNVFEN------------------------LSKDGW-------EDVSESSSDSEAQ 878
I + V +N L KD + E + S +
Sbjct: 946 IAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKE 1005
Query: 879 TSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGK------EIVQTYLNIDGKTPK 932
+++ + T +K+ E +Q+ E S + K +IV I K
Sbjct: 1006 QVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMK 1065
Query: 933 DYFHDKNA----KKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERI 988
+ + A K + + K + + + T+ N+ AQK +LR+ +
Sbjct: 1066 ELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQ---MLRDEL 1122
Query: 989 -------ISLQQQNSVLQNAKKTAELSVK--EYKEVNEKLLHQQQVSDQRFQTSRQTIKK 1039
+S + +L+ K EL V+ + +E+++ Q ++ + + Q+ + ++
Sbjct: 1123 ADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVES 1182
Query: 1040 LNLDLAGLRKEKED--LLKKLESS------SEITSLAE-ENSQVTFPRIQVTSLSPSRSM 1090
L + L + + ++ L+ KL SE T+L + E+ +++ +L + +
Sbjct: 1183 LRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL 1242
Query: 1091 DLEMKQLQYKLKNATNELTKQSSNVKTLKFEL-----LAKEEHIKEMHEKISRMERDITM 1145
D + + L Y N +++L+ + LA++E + + + +++ D
Sbjct: 1243 DEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQE---KFSKTMIQLQND--- 1296
Query: 1146 KRHLIEDLKFRQKVNLESNKSFSEM---LQNLDKKVKTLTEECSNKKVSIDSLKQRLNVA 1202
K +++++K Q+ + EM L+ L++ + TL + +KV +N
Sbjct: 1297 KLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV--------INWH 1348
Query: 1203 VK-EKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQ---------- 1251
+K E+ + +++ K EL K ++ L + ISE E ++ +E +Q
Sbjct: 1349 MKIEELRLQEL--KLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA 1406
Query: 1252 --LQELALQSE-QVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRE-LKK 1307
+E+ L+ + + + Q +L A +K EE T + + L N + + R+I+E ++
Sbjct: 1407 WDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRI 1466
Query: 1308 MKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWML--- 1364
+ + R CK+ K + +++ R + IL + + + ++ A ++E ++
Sbjct: 1467 ILETRATCKSLEEKLKEKESAL----RLAEQNILSRDKVINELRLRLPATAEREKLIAEL 1522
Query: 1365 ---YIQKLLEGQLPFASYLLEAVLEKINEKKKLVEGYFTIMKDIR 1406
++ L A + + ++N+K+++++ Y +++ R
Sbjct: 1523 GRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAR 1567
Score = 95.1 bits (235), Expect = 4e-19
Identities = 217/1117 (19%), Positives = 439/1117 (39%), Gaps = 179/1117 (16%)
Query: 105 LEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLE 164
LEE+L + L L + + + L++ P + L+ E +++ E K L+
Sbjct: 1477 LEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLK 1536
Query: 165 ILQVKDAKIQ-EFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLE----------- 212
I A +Q Q+E VLK+ L K + +E+ ++K DL
Sbjct: 1537 IAHQTIANMQARLNQKEEVLKKYQRLLEKAR---EEQREIVKKHEEDLHILHHRLELQAD 1593
Query: 213 ---KKFKDKSQEI-KDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQE 268
KFK + ++ K + V + RL E + ++ + L + L KL+K
Sbjct: 1594 SSLNKFKQTAWDLMKQSPTPVPTNKHFIRLA-----EMEQTVAEQDDSLSSLLVKLKKVS 1648
Query: 269 AHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVR 328
L +++ T+ K+K FE+ ++ ++ E K A ++ + + L Q + ++
Sbjct: 1649 QDLERQREITELKVKEFENIKLQLQENHEDEVKKVKA---EVEDLKYLLDQSQKESQCLK 1705
Query: 329 KELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELH 388
ELQ + + T T + L+++L+ +Q L+ ++ A S + +L E+
Sbjct: 1706 SELQAQKEANSRAPTTTMRN--LVERLK-----SQLALKEKQQ--KALSRALLELRAEMT 1756
Query: 389 ICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQV 448
E + +++ N+Q + + +E E L E+
Sbjct: 1757 AAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNEN------------------- 1797
Query: 449 PHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEP 508
L L+ + + K+ L + L N +L + A R+ E +
Sbjct: 1798 -----LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKR 1852
Query: 509 PVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERL-- 566
+KR S TD+++ + + +RK++ LE L+ K +E D + KE L
Sbjct: 1853 QIKRLTSGLQGKPLTDNKQ-SLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIR 1911
Query: 567 ----QMLQTNYRAVKEQLKQWEEGSGMTEIRKIK-------RADPQQLRQEDSDAVWNEL 615
+ Q ++ +LK+ +EG T +++ +AD ++L +
Sbjct: 1912 WEEGKKWQAKIEGIRNKLKE-KEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
Query: 616 AYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVK 675
+Q L I+ + E+EL+ELK K + N + R + L R +++
Sbjct: 1971 V-----DQVLGIRALESEKELEELK------KRNLDLENDILYMRAHQALPRDSVVEDLH 2019
Query: 676 RSTPEKNGK-EMLEQTLQKVTELENRLKSFE-----KRSRKLKEGNKKLMKENDFLKSLL 729
K LE+ K T + + E +R ++L++ N KL EN LK L
Sbjct: 2020 LQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQL 2079
Query: 730 KQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENE 789
+Q +D + ++ + + + ++KE E+Q K+ + R + E E
Sbjct: 2080 EQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHV--------RGSGRSGKTIPELE 2131
Query: 790 ELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHS 849
+ I M+K ++ + E +K SG + M ++ + K + + L H
Sbjct: 2132 KTIGLMKK---VVEKVQRENEQLKKASGILTSE-KMANIEQENEKLKAELEKLKAHLGHQ 2187
Query: 850 IKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPT 909
+S +E+ +K + ++E+ + +T + ++K+ ++ + T
Sbjct: 2188 ---LSMHYESKTKGTEKIIAENERLRKELKKET------DAAEKLRIAKNNLEILNEKMT 2238
Query: 910 EDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKY 969
+ GK + ++ P + + K KS V TR+ K
Sbjct: 2239 VQLEETGKRL----------------QFAESRGPQLEGADSKSWKS---IVVTRMYETKL 2279
Query: 970 KNITAQ--KSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSD 1027
K + K + +I L++ + ++ + + E +K K V E +Q +
Sbjct: 2280 KELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGL-- 2337
Query: 1028 QRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPS 1087
++ ++ L L L KEK +L+ ++E++ + + ++ T P
Sbjct: 2338 ------KRELQVLRLANHQLDKEKAELIHQIEANKD-----QSGAESTIP---------- 2376
Query: 1088 RSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKR 1147
+ QL+ K+K+ +L + LK E IK++ +++ + +
Sbjct: 2377 -----DADQLKEKIKDLETQLKMSDLEKQHLK-------EEIKKLKKELENFDPSFFEE- 2423
Query: 1148 HLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEE 1184
IEDLK+ K ++ N L++KVK L+E+
Sbjct: 2424 --IEDLKYNYKEEVKKNIL-------LEEKVKKLSEQ 2451
Score = 88.2 bits (217), Expect = 5e-17
Identities = 161/804 (20%), Positives = 339/804 (42%), Gaps = 106/804 (13%)
Query: 633 EEELDELKVHISIDKAAIQELNRCVAERREE--QLFR--------SGEDDEVKRSTPEKN 682
+EEL + + IS+ K + EL +E++E LFR ++ E+ EK
Sbjct: 21 QEELAD-NLLISLSKVEVNELK---SEKQENVIHLFRITQSLMKMKAQEVELALEEVEKA 76
Query: 683 GKEMLE---QTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETR 739
G+E + Q KV +LEN L+ ++ + ++ FL++ + Q ++ E +
Sbjct: 77 GEEQAKFENQLKTKVMKLENELEMAQQSAGG---------RDTRFLRNEICQLEKQLEQK 127
Query: 740 EKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSH 799
++ELE + K + +K N +L ++ E E E + LRR E L+ +NE+L +
Sbjct: 128 DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRR---ENKRLKKKNEQLCQDIIDYQ 184
Query: 800 QSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFEN 859
+ D K + + + Y + + +KKN + ++ + ++ + E
Sbjct: 185 KQIDSQKETLLSRRGEDSDY---------RSQLSKKNYELIQYLDEI-QTLTEANEKIEV 234
Query: 860 LSKDGWEDVSESSSDSEAQTSQ--TLGTIIVETSQKISPTEDGKDQKESDPTE-----DS 912
+++ +++ ES + E T + + I+ +T I + D + E S
Sbjct: 235 QNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKS 294
Query: 913 QTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNI 972
+ + + + +N + K K+ + +Q+ + REK KN
Sbjct: 295 KNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNL-------------REKLKNA 341
Query: 973 TAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKE---VNEKLLHQQQVSDQR 1029
SN++ L++ +Q+++S ++ + E KE ++ + E L ++ Q +
Sbjct: 342 QLDADKSNVMALQQ---GIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGA 398
Query: 1030 FQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITS-LAEENSQVTFPRI--QVTSLSP 1086
S+QT K+ L D+LK+ +E T+ LAE +++ + + L
Sbjct: 399 STLSQQTHMKIQSTL--------DILKEKTKEAERTAELAEADAREKDKELVEALKRLKD 450
Query: 1087 SRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMK 1146
S ++ ++KN N++ + ++ L E+ E I + ++ + + ++
Sbjct: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLE 510
Query: 1147 RHLIEDL-KFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKE 1205
+ DL +FR +L+ + +E Q L K++++L EE + K I + Q
Sbjct: 511 PKTMIDLTEFRNSKHLKQQQYRAEN-QILLKEIESLEEERLDLKKKIRQMAQ-------- 561
Query: 1206 KSQYEQMYQKSKEELEKKDLKLTLLVS---RISETESAMAEIETAASKQLQELALQSEQV 1262
E+ + + L +DL LT +S RISE + + ++ + Q + L E +
Sbjct: 562 ----ERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELI 617
Query: 1263 LEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKA 1322
+ ++ L + + +F +K L +E + ++ ++ +K+M+K+ D T
Sbjct: 618 EK--ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLI 675
Query: 1323 QTLAASILN-ISRSDLEEILDTEDQVEIEKTKIDAEND----------KEWMLYIQKLLE 1371
++N I + E I D ++ + ++ N+ KE + Y Q+L +
Sbjct: 676 IPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAK 735
Query: 1372 GQLPFASYLLEAVLEKINEKKKLV 1395
L E L + +E +V
Sbjct: 736 ANLKIDHLEKETSLLRQSEGSNVV 759
Score = 80.1 bits (196), Expect = 1e-14
Identities = 182/941 (19%), Positives = 393/941 (41%), Gaps = 147/941 (15%)
Query: 523 TDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQ-----TNYRAVK 577
T S K ++ E +E +EKA + +++ ++L+ K + L+M Q + R ++
Sbjct: 55 TQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLR 114
Query: 578 EQLKQWEEGSGM---------TEIRKIKRADPQ-QLRQEDSDAVWNELAYFKRENQELMI 627
++ Q E+ E+ K K+ + Q LR E+++ NE + +REN+ L
Sbjct: 115 NEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE---NENSKLRRENKRLKK 171
Query: 628 QKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEML 687
+ L +++ + + I ++E L R GED + + +KN
Sbjct: 172 KNEQLCQDIIDYQKQID--------------SQKETLLSRRGEDSDYRSQLSKKN----- 212
Query: 688 EQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKE---LE 744
+ +Q + E++ L E N+K+ +N ++ L++ ++ E E ++
Sbjct: 213 YELIQYLDEIQT-----------LTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMK 261
Query: 745 QIIKGSKDV----EKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQ 800
I+ + +V +KEN Q+++ EL + L+++NEE M +
Sbjct: 262 AIVHQTDNVIDQLKKENDHYQLQVQEL-------------TDLLKSKNEEDDPIMVAVNA 308
Query: 801 SADRAKSEMAT-----MKVRSGRYDCKTTMTKVKFKAAKKN-CSVGRHHTVLNHSIKVMS 854
+ K +++ ++ + ++ + + + A K N ++ + + IK+++
Sbjct: 309 KVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLT 368
Query: 855 NVFENLSKDGWEDVS-ESSSDSEAQTSQTLGTIIVETSQKISPTED--GKDQKESDPT-- 909
E +K+ ++ +E Q ++ T+ +T KI T D + KE++ T
Sbjct: 369 EQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAE 428
Query: 910 ---EDSQTQGKEIVQTYLNIDGKTPKDYFHD-KNAKKPTFQKKNCKMQKSSHTAVPTRVN 965
D++ + KE+V+ K KDY + + KNCK Q +
Sbjct: 429 LAEADAREKDKELVEAL-----KRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILT 483
Query: 966 REKYK-NITAQKSSSNIILLRERIISLQQQNSV-LQNAKKTAELSVKEYKEVNEKLLHQQ 1023
+E K + LRER + L+ + + L + + L ++Y+ N+ LL +
Sbjct: 484 KEINKLELKISDFLDENEALRER-VGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEI 542
Query: 1024 QVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTS 1083
+ ++ ++ I+++ + G R L + + +E S + S+ + + +
Sbjct: 543 ESLEEERLDLKKKIRQMAQE-RGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKN 601
Query: 1084 LSPSRS----MDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRM 1139
+S ++S + E+ + + L+ + + K + +K L E EE +KE+ + I M
Sbjct: 602 MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEM 661
Query: 1140 ERDITMK----RHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSL 1195
++D +K +I L+ + VN +K+ +E + + +K ++ + + + L
Sbjct: 662 QKDPDVKGGETSLIIPSLE--RLVNAIESKN-AEGIFDASLHLKAQVDQLTGRN---EEL 715
Query: 1196 KQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLL--------VSRISETESAMAEIETA 1247
+Q L + KE Y Q K+ +++ + + +LL V + + +A +
Sbjct: 716 RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSAS 775
Query: 1248 ASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFV-------KALAKELQNDVHVVRR 1300
E + Q LE +K L + +E++ L KE ++ +
Sbjct: 776 IINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKT 835
Query: 1301 QIRELKKMKK------NRDACKTSTHKAQTLAASILNISRSDLEEI--LDTEDQVEIEKT 1352
+ + +K+ K+ +DA K + ++LN + D +E+ + E+ +I
Sbjct: 836 ESKTIKEEKRKLEDQVQQDAIKVKEYN------NLLNALQMDSDEMKKILAENSRKITVL 889
Query: 1353 KIDAENDKEWMLYIQKLLEGQLPFASYLLEAVLEKINEKKK 1393
++ N+K + L+E LE L K NEK+K
Sbjct: 890 QV---NEKSLIRQYTTLVE---------LERQLRKENEKQK 918
Score = 53.1 bits (126), Expect = 2e-06
Identities = 82/401 (20%), Positives = 173/401 (43%), Gaps = 52/401 (12%)
Query: 1037 IKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVT-SLSPSRSMDLEM- 1094
I K++ D ++E D L S E+ L E + ++T SL ++ ++E+
Sbjct: 10 IMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELA 69
Query: 1095 ---------------KQLQYKLKNATNEL--TKQSSNVKTLKF---ELLAKEEHIKEMHE 1134
QL+ K+ NEL +QS+ + +F E+ E+ +++
Sbjct: 70 LEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDR 129
Query: 1135 KISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDS 1194
++ ME+++ ++ + E L R + N + L KK + L ++ + + IDS
Sbjct: 130 ELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDS 189
Query: 1195 LKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQE 1254
K+ L E S Y + +L KK+ +L + I A +IE Q QE
Sbjct: 190 QKETLLSRRGEDSDY-------RSQLSKKNYELIQYLDEIQTLTEANEKIEV----QNQE 238
Query: 1255 LALQSEQVLEGAQKTLLLANEK---VEEFTTFVKALAKELQNDVHVVR-RQIRELKKMKK 1310
+ E+ ++ +K N V + + L KE ND + ++ +++ +L K K
Sbjct: 239 MRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKE--NDHYQLQVQELTDLLKSKN 296
Query: 1311 NRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQV-----EIEKTKIDAENDKEWMLY 1365
D A+ ++ S+ D EI++ + + +++ ++DA DK ++
Sbjct: 297 EEDDPIMVAVNAKVEEWKLILSSKDD--EIIEYQQMLHNLREKLKNAQLDA--DKSNVMA 352
Query: 1366 IQKLLEGQLPFASYLLEAVLEKINEKKKLVEGYFTIMKDIR 1406
+Q+ ++ + ++ + E++ + K +E I++D++
Sbjct: 353 LQQGIQER----DSQIKMLTEQVEQYTKEMEKNTCIIEDLK 389
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.124 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,825,882
Number of Sequences: 37866
Number of extensions: 2171727
Number of successful extensions: 34435
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 477
Number of HSP's successfully gapped in prelim test: 1441
Number of HSP's that attempted gapping in prelim test: 14073
Number of HSP's gapped (non-prelim): 10204
length of query: 1406
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1291
effective length of database: 13,892,928
effective search space: 17935770048
effective search space used: 17935770048
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.