Search of human proteins with 110611226

Search of human proteins with 110611226

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
         (1591 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]                  3229   0.0  
gi|122937247 unc-13 homolog A [Homo sapiens]                         2461   0.0  
gi|122937514 unc-13 homolog C [Homo sapiens]                         1850   0.0  
gi|46195765 unc-13 homolog D [Homo sapiens]                           129   2e-29
gi|15451914 BAI1-associated protein 3 [Homo sapiens]                  109   2e-23
gi|13384594 protein kinase C, gamma [Homo sapiens]                     81   7e-15
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            77   1e-13
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            77   1e-13
gi|4506067 protein kinase C, alpha [Homo sapiens]                      77   2e-13
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi...    75   7e-13
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi...    75   7e-13
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    72   6e-12
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    72   6e-12
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    72   6e-12
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]    70   2e-11
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi...    70   2e-11
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi...    70   2e-11
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi...    70   2e-11
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi...    70   2e-11
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi...    70   2e-11
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi...    70   2e-11
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    70   2e-11
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    70   2e-11
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]              64   2e-09
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]             64   2e-09
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]             64   2e-09
gi|5453976 protein kinase C, theta [Homo sapiens]                      63   3e-09
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom...    62   4e-09
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom...    62   4e-09
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom...    62   4e-09

>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
          Length = 1591

 Score = 3229 bits (8373), Expect = 0.0
 Identities = 1591/1591 (100%), Positives = 1591/1591 (100%)

Query: 1    MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL 60
            MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL
Sbjct: 1    MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL 60

Query: 61   SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK 120
            SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK
Sbjct: 61   SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK 120

Query: 121  ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP 180
            ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP
Sbjct: 121  ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSFEDP 180

Query: 181  DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM 240
            DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM
Sbjct: 181  DSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSM 240

Query: 241  QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH 300
            QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH
Sbjct: 241  QSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSH 300

Query: 301  SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF 360
            SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF
Sbjct: 301  SLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESF 360

Query: 361  PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR 420
            PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR
Sbjct: 361  PEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLR 420

Query: 421  RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF 480
            RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF
Sbjct: 421  RKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNF 480

Query: 481  EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA 540
            EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA
Sbjct: 481  EVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGA 540

Query: 541  EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA 600
            EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA
Sbjct: 541  EDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSA 600

Query: 601  KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD 660
            KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD
Sbjct: 601  KITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSD 660

Query: 661  RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG 720
            RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG
Sbjct: 661  RIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSG 720

Query: 721  AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE 780
            AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE
Sbjct: 721  AIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDE 780

Query: 781  TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN 840
            TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN
Sbjct: 781  TAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTN 840

Query: 841  VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI 900
            VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI
Sbjct: 841  VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSI 900

Query: 901  TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP 960
            TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP
Sbjct: 901  TFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGP 960

Query: 961  SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE 1020
            SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE
Sbjct: 961  SIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALE 1020

Query: 1021 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS 1080
            EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS
Sbjct: 1021 EHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVS 1080

Query: 1081 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR 1140
            LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR
Sbjct: 1081 LEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRR 1140

Query: 1141 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA 1200
            FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA
Sbjct: 1141 FAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEA 1200

Query: 1201 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ 1260
            ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ
Sbjct: 1201 ADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQ 1260

Query: 1261 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ 1320
            DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ
Sbjct: 1261 DADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQ 1320

Query: 1321 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK 1380
            LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK
Sbjct: 1321 LIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEK 1380

Query: 1381 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKV 1440
            SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKV
Sbjct: 1381 SPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKV 1440

Query: 1441 TVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLG 1500
            TVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLG
Sbjct: 1441 TVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLG 1500

Query: 1501 NEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLT 1560
            NEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLT
Sbjct: 1501 NEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLT 1560

Query: 1561 ILRILSQRSNDEVAREFVKLKSESRSTEEGS 1591
            ILRILSQRSNDEVAREFVKLKSESRSTEEGS
Sbjct: 1561 ILRILSQRSNDEVAREFVKLKSESRSTEEGS 1591


>gi|122937247 unc-13 homolog A [Homo sapiens]
          Length = 1791

 Score = 2461 bits (6378), Expect = 0.0
 Identities = 1251/1707 (73%), Positives = 1398/1707 (81%), Gaps = 127/1707 (7%)

Query: 1    MSLLCVRVKRAKFQGSPDKFNTYVTLKVQNVKSTTVAVRGDQPSWEQDFMFEISRLDLGL 60
            MSLLCV VK+AKF G+ +KFNTYVTLKVQNVKSTT+AVRG QPSWEQDFMFEI+RLDLGL
Sbjct: 89   MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGL 148

Query: 61   SVEVWNKGLIWDTMVGTVWIALKTIRQSDEEGPGEWSTLEAETLMKDDEICGTRNPTPHK 120
            +VEVWNKGLIWDTMVGTVWI L+TIRQS+EEGPGEW TL+++ +M D EICGT++PT H+
Sbjct: 149  TVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQVIMADSEICGTKDPTFHR 208

Query: 121  ILLDTRFELPFDIPEEEARYWTYKWEQINALGADNEYSSQEESQRKPLPTAAAQCSF--- 177
            ILLDTRFELP DIPEEEARYW  K EQ+NA+   +EYS Q+E Q KPLP  + QC     
Sbjct: 209  ILLDTRFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDE-QDKPLPVPSNQCCNWNY 267

Query: 178  --------EDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQ 229
                    +DPDSAVDDRDSDYRSETSNS PPPY+T SQPNASVHQ+ V    P  L   
Sbjct: 268  FGWGEQHNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSV---RPPPL--- 321

Query: 230  GSSRDSCNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSE---LDQYHEQD-- 284
              SR+S +DSM SY+ ++ E +A+SPT SSRY SS  +SQGSSQLSE    D++  Q   
Sbjct: 322  -GSRESYSDSMHSYE-EFSEPQALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSD 379

Query: 285  -DDHRETDSIHSCHSSHSLSRDG----------------------------QAGFGEQEK 315
             +D R+ DS HSCHSS S  +D                             +    E+E 
Sbjct: 380  MEDERDRDSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPEDEEELEEEEEEV 439

Query: 316  PLEVTGQAEKE--AACEPKEMK-----------ED----ATTHPP-----------PDLV 347
            P ++   A++E  A  EPK+ K           ED    A T  P           PD V
Sbjct: 440  PDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAPTEAPDMAKVAPKPATPDKV 499

Query: 348  LQKDHF-----------LGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDP 396
               +               P+E    +      ++A+A+W+RA  KVR+QLQE   +G+ 
Sbjct: 500  PAAEQIPEAEPPKDEESFRPREDEEGQEGQDSMSRAKANWLRAFNKVRMQLQEARGEGEM 559

Query: 397  SLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDL--SLVQSRKAGITSAMATRTSLKDE 454
            S   W   GP GGL  IDSMPD+R++KP+PLVSDL  SLVQSRKAGITSA+A+ T L +E
Sbjct: 560  SKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALASST-LNNE 618

Query: 455  ELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVK 514
            ELK+HVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRC+ECGVK
Sbjct: 619  ELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVK 678

Query: 515  CHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFT 574
            CHEKCQDLLNADCLQRAAEKS KHGAEDRTQNIIM +KDRMKIRERNKPEIFE+I+++F 
Sbjct: 679  CHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFA 738

Query: 575  VNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKK 634
            V K AH QQMK VKQSVLDGTSKWSAKI+ITVVCAQGLQAKDKTGSSDPYVTVQV KTKK
Sbjct: 739  VTKTAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKK 798

Query: 635  RTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTII 694
            RTKTI+GNLNPVWEE FHFECHNSSDRIKVRVWDEDDDIKSRVKQR KRESDDFLGQTII
Sbjct: 799  RTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTII 858

Query: 695  EVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYL 754
            EVRTLSGEMDVWYNL+KRTDKSAVSGAIRL ISVEIKGEEKVAPYHVQYTCLHENLFH++
Sbjct: 859  EVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFV 918

Query: 755  TDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMC 814
            TD+Q +G V+IP+A+GDDAWKVY+DETAQEIVDEFAMRYG+ESIYQAMTHFACLSSKYMC
Sbjct: 919  TDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMC 978

Query: 815  PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLST 874
            PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLS 
Sbjct: 979  PGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSM 1038

Query: 875  YRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEY 934
            YRNNFPA SPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEY
Sbjct: 1039 YRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEY 1098

Query: 935  IFNNCHDLYSRQYQL----KQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVL 990
            IFNNCH+LYSR+YQ     K E+ PEEQGPSI+NLDFW KLITLIVSIIEEDKNSYTP L
Sbjct: 1099 IFNNCHELYSREYQTDPAKKGEVLPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCL 1158

Query: 991  NQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRD 1050
            NQFPQELNVGK+SAEVMW+LFAQDMKYA+EEH+K  LCKSADYMNLHFKVKWL+NEYV +
Sbjct: 1159 NQFPQELNVGKISAEVMWNLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVTE 1218

Query: 1051 LPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVV 1110
            LP  + +VPEYPAWFE FV+QWLDENE+VS +FL GALERDKKDGFQQTSEHALFSCSVV
Sbjct: 1219 LPAFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVV 1278

Query: 1111 DVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCT--KEK 1168
            DVF+QLNQSFEII+KLECPDP I+ HYMRRFAKTI  VL+QYADI+SKDF +YC+  KEK
Sbjct: 1279 DVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIISKDFASYCSKEKEK 1338

Query: 1169 LPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQV 1228
            +PCILMNN QQLRVQLEKMFEAMGGKELD EA+D LKELQVKLN VLDELS VF  SFQ 
Sbjct: 1339 VPCILMNNTQQLRVQLEKMFEAMGGKELDAEASDILKELQVKLNNVLDELSRVFATSFQP 1398

Query: 1229 RIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTV 1288
             I+ECV+QM DIL QV+GTGN    A +S AQDAD+VL+P+MD LD NLTLFA +CEKTV
Sbjct: 1399 HIEECVKQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTV 1458

Query: 1289 LKRVLKELWRVVMNTMERMIVLPPLTDQT-------------------------GTQLIF 1323
            LKRVLKELW++VMNTME+ IVLPPLTDQT                         GTQ+IF
Sbjct: 1459 LKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGNLLRKHGKGLEKGRVKLPSHSDGTQMIF 1518

Query: 1324 TAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPD 1383
             AAKEL  LSKLKDHMVREE ++LTPKQCAV++LALDTIKQYFHAGG GLKKTFLEKSPD
Sbjct: 1519 NAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPD 1578

Query: 1384 LQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVK 1443
            LQSLRYALSLYTQ TD LIKTFV++Q+ QG GV+DPVGEVS+ V+LFTHPGTGEHKVTVK
Sbjct: 1579 LQSLRYALSLYTQATDLLIKTFVQTQSAQGLGVEDPVGEVSVHVELFTHPGTGEHKVTVK 1638

Query: 1444 VVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEE 1503
            VVAANDLKWQT+G+FRPF+EV ++GP  SDKKRKF TKSK+N+WAPKYNE+F F L  + 
Sbjct: 1639 VVAANDLKWQTSGIFRPFIEVNIIGPQLSDKKRKFATKSKNNSWAPKYNESFQFTLSADA 1698

Query: 1504 GPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILR 1563
            GPE YELQ+CVKDYCFAREDR +GLAV+ LR++  +GS ACW PLGR+IHMD+TGLT+LR
Sbjct: 1699 GPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLR 1758

Query: 1564 ILSQRSNDEVAREFVKLKSESRSTEEG 1590
            ILSQRSNDEVA+EFVKLKS++RS EEG
Sbjct: 1759 ILSQRSNDEVAKEFVKLKSDTRSAEEG 1785


>gi|122937514 unc-13 homolog C [Homo sapiens]
          Length = 2214

 Score = 1850 bits (4791), Expect = 0.0
 Identities = 893/1192 (74%), Positives = 1039/1192 (87%), Gaps = 6/1192 (0%)

Query: 405  GPAGGLYGIDSMPDLRRKKPLPLVSDLSL-VQSRKAGITSAMATRTSLKDEELKSHVYKK 463
            G  GGLYGIDSMPDLRRKK LP+V D+++ + +RK+G++ AM  RTSL +EELK HV+KK
Sbjct: 1024 GAGGGLYGIDSMPDLRRKKTLPIVRDVAMTLAARKSGLSLAMVIRTSLNNEELKMHVFKK 1083

Query: 464  TLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLL 523
            TLQALIYP+S T PHNFEVWTATTPTYCYECEGLLWGIARQGM+C ECGVKCHEKCQDLL
Sbjct: 1084 TLQALIYPMSSTIPHNFEVWTATTPTYCYECEGLLWGIARQGMKCLECGVKCHEKCQDLL 1143

Query: 524  NADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQ 583
            NADCLQRAAEKS KHGAED+TQ II AMK+RMKIRE+N+PE+FEVI+++F ++K   VQ 
Sbjct: 1144 NADCLQRAAEKSSKHGAEDKTQTIITAMKERMKIREKNRPEVFEVIQEMFQISKEDFVQF 1203

Query: 584  MKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNL 643
             K  KQSVLDGTSKWSAKITITVV AQGLQAKDKTGSSDPYVTVQV K K+RTKTIFGNL
Sbjct: 1204 TKAAKQSVLDGTSKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNL 1263

Query: 644  NPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEM 703
            NPVW+EKF+FECHNS+DRIKVRVWDEDDDIKSRVKQ  K+ESDDFLGQTI+EVRTLSGEM
Sbjct: 1264 NPVWDEKFYFECHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEM 1323

Query: 704  DVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGV 763
            DVWYNLEKRTDKSAVSGAIRL+I+VEIKGEEKVAPYH+QYTCLHENLFHYLT+++ +GGV
Sbjct: 1324 DVWYNLEKRTDKSAVSGAIRLKINVEIKGEEKVAPYHIQYTCLHENLFHYLTEVKSNGGV 1383

Query: 764  RIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMST 823
            +IPE +GD+AWKV+FD+ +QEIVDEFAMRYGIESIYQAMTHF+CLSSKYMCPGVPAVMST
Sbjct: 1384 KIPEVKGDEAWKVFFDDASQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCPGVPAVMST 1443

Query: 824  LLANINAYYAHTTASTN--VSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNFPA 881
            LLANINA+YAHTT STN  VSASDRFAA+NFG+E+F+KLLDQLHNSLRIDLS YR NFPA
Sbjct: 1444 LLANINAFYAHTTVSTNIQVSASDRFAATNFGREKFIKLLDQLHNSLRIDLSKYRENFPA 1503

Query: 882  GSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHD 941
             + ERLQDLKSTVDLLTSITFFRMKV ELQSPP+AS VVKDCV+ACL+STY+YIF+NCH+
Sbjct: 1504 SNTERLQDLKSTVDLLTSITFFRMKVLELQSPPKASMVVKDCVRACLDSTYKYIFDNCHE 1563

Query: 942  LYSR--QYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNV 999
            LYS+      KQ++P E+QGP+ +NLDFWP+LITL+V+II+EDK +YTPVLNQFPQELN+
Sbjct: 1564 LYSQLTDPSKKQDIPREDQGPTTKNLDFWPQLITLMVTIIDEDKTAYTPVLNQFPQELNM 1623

Query: 1000 GKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQVP 1059
            GK+SAE+MW LFA DMKYALEEHE   LCKS DYMNLHFKVKW +NEYVR+LP  +  VP
Sbjct: 1624 GKISAEIMWTLFALDMKYALEEHENQRLCKSTDYMNLHFKVKWFYNEYVRELPAFKDAVP 1683

Query: 1060 EYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQS 1119
            EY  WFE FV+QWLDENEDVS+EFL GAL RDKKDGFQQTSEHALFSCSVVDVF QLNQS
Sbjct: 1684 EYSLWFEPFVMQWLDENEDVSMEFLHGALGRDKKDGFQQTSEHALFSCSVVDVFAQLNQS 1743

Query: 1120 FEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQ 1179
            FEII+KLECP+P  L+H MRRFAKTI KVL+QYA I+S DF ++C KE +PCILMNN+QQ
Sbjct: 1744 FEIIKKLECPNPEALSHLMRRFAKTINKVLLQYAAIVSSDFSSHCDKENVPCILMNNIQQ 1803

Query: 1180 LRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMAD 1239
            LRVQLEKMFE+MGGKELD EA+  LKELQVKL+ VLDELS+ +G SFQV I+EC++QM+ 
Sbjct: 1804 LRVQLEKMFESMGGKELDSEASTILKELQVKLSGVLDELSVTYGESFQVIIEECIKQMSF 1863

Query: 1240 ILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRV 1299
             L Q+R  GN + + + SAA DA+ VLR LMDFLD  L+L A +CEKTVLKRVLKELW++
Sbjct: 1864 ELNQMRANGNTTSN-KNSAAMDAEIVLRSLMDFLDKTLSLSAKICEKTVLKRVLKELWKL 1922

Query: 1300 VMNTMERMIVLPPLTDQTGTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLAL 1359
            V+N +E+ IVLPPLTDQTG Q+IF AAK+L  LSKLK+HM+RE+ R LTP+QCA++++ L
Sbjct: 1923 VLNKIEKQIVLPPLTDQTGPQMIFIAAKDLGQLSKLKEHMIREDARGLTPRQCAIMEVVL 1982

Query: 1360 DTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDP 1419
             TIKQYFHAGGNGLKK FLEKSPDLQSLRYALSLYTQTTD LIK F+ +QT+Q     D 
Sbjct: 1983 ATIKQYFHAGGNGLKKNFLEKSPDLQSLRYALSLYTQTTDALIKKFIDTQTSQSRSSKDA 2042

Query: 1420 VGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFT 1479
            VG++S+ VD+   PGTG+HKVTVKV+A NDL WQT  MFRPFVEV ++GP+  DKKRK  
Sbjct: 2043 VGQISVHVDITATPGTGDHKVTVKVIAINDLNWQTTAMFRPFVEVCILGPNLGDKKRKQG 2102

Query: 1480 TKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAK 1539
            TK+KSN W+PKYNETF F+LG E  P +YEL + VKDYCFAREDR++G+ V+ L+++  K
Sbjct: 2103 TKTKSNTWSPKYNETFQFILGKENRPGAYELHLSVKDYCFAREDRIIGMTVIQLQNIAEK 2162

Query: 1540 GSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFVKLKSESRSTEEGS 1591
            GS   W PL + I MDETGLTILRILSQR++D+VA+EFV+LKSE+RSTEE +
Sbjct: 2163 GSYGAWYPLLKNISMDETGLTILRILSQRTSDDVAKEFVRLKSETRSTEESA 2214


>gi|46195765 unc-13 homolog D [Homo sapiens]
          Length = 1090

 Score =  129 bits (325), Expect = 2e-29
 Identities = 237/1100 (21%), Positives = 435/1100 (39%), Gaps = 187/1100 (17%)

Query: 564  EIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDP 623
            E+   +++ F V    H Q ++ V++       K    +  TV  A+G+  KD +G SDP
Sbjct: 80   ELLRYLQEAFHVEPEEHQQTLQRVRE-----LEKPIFCLKATVKQAKGILGKDVSGFSDP 134

Query: 624  YVTVQVSK--------------------------TKKRTKTIFGNLNPVWEEKFHFECHN 657
            Y  + + +                             RT+ I   LNPVW+E F  E  +
Sbjct: 135  YCLLGIEQGVGVPGGSPGSRHRQKAVVRHTIPEEETHRTQVITQTLNPVWDETFILEFED 194

Query: 658  SSDR-IKVRVWDEDDDIKSRVK----------QRLKRES------DDFLGQTIIEVRTLS 700
             ++    + +WD D     R K          +R+ +E+      DDFLG  ++ ++ L 
Sbjct: 195  ITNASFHLDMWDLDTVESVRQKLGELTDLHGLRRIFKEARKDKGQDDFLGNVVLRLQDLR 254

Query: 701  GEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGS 760
               D WY LE RT+     G   LQ  +  K     A        +H +L   L     S
Sbjct: 255  CREDQWYPLEPRTETYPDRGQCHLQFQLIHKRRATSASRSQPSYTVHLHLLQQLV----S 310

Query: 761  GGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAV 820
              V   EA G  +W       A  ++   A +  +   +Q+M  +   S  Y     P+ 
Sbjct: 311  HEVTQHEA-GSTSWDGSLSPQAATVLFLHATQKDLSDFHQSMAQWLAYSRLYQSLEFPS- 368

Query: 821  MSTLLANINAY-YAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRNNF 879
             S LL  I +  Y            +  AAS      F  LL    + +R     +R+ F
Sbjct: 369  -SCLLHPITSIEYQWIQGRLKAEQQEELAAS------FSSLLTYGLSLIR----RFRSVF 417

Query: 880  P---AGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIF 936
            P   + SP RLQ L   +  +  +  F       +  P  + + +   +A    T E+  
Sbjct: 418  PLSVSDSPARLQSLLRVLVQMCKMKAFG------ELCPNTAPLPQLVTEALQTGTTEWF- 470

Query: 937  NNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQE 996
               H        + Q +P  E G ++  L      +  ++  + + + ++  + +     
Sbjct: 471  ---HLKQQHHQPMVQGIP--EAGKALLGL------VQDVIGDLHQCQRTWDKIFH----- 514

Query: 997  LNVGKVSAEVMWHLFA---QDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYV--RDL 1051
             N  K+      HLF+   +++++ + +  +DH     D ++       L   Y+  ++L
Sbjct: 515  -NTLKI------HLFSMAFRELQWLVAKRVQDHTTVVGDVVSPEMGES-LFQLYISLKEL 566

Query: 1052 PVLQGQVPE---------YPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEH 1102
              L+    E         +  WF+  +  WL +  + +L  ++ A++ D+     + ++H
Sbjct: 567  CQLRMSSSERDGVLALDNFHRWFQPAIPSWLQKTYNEALARVQRAVQMDELVPLGELTKH 626

Query: 1103 ALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGKVLMQYADILSKDFPA 1162
               S S VD+ T   Q     R+L+ PDP        +F +   ++ + Y  ++      
Sbjct: 627  ---STSAVDLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARE 683

Query: 1163 YCTKEK-------LPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVL 1215
              + +K       + C+++N+++QLR+ + K+   +  + L+      L++ Q++ NT+ 
Sbjct: 684  LSSGQKDQGQAANMLCVVVNDMEQLRLVIGKLPAQLAWEALEQRVGAVLEQGQLQ-NTLH 742

Query: 1216 DEL-SMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAAQDA---DSVLRPLMD 1271
             +L S + G   ++R    VR +A+ L      G A    +    +++   +  + PLM 
Sbjct: 743  AQLQSALAGLGHEIRTG--VRTLAEQLE----VGIAKHIQKLVGVRESVLPEDAILPLMK 796

Query: 1272 FLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAKELSH 1331
            FL+  L    T   +     +L  LW                   T T L+  AA + S 
Sbjct: 797  FLEVELCYMNTNLVQENFSSLLTLLWT-----------------HTLTVLVEAAASQRS- 838

Query: 1332 LSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYAL 1391
             S L  + ++               +AL  ++  FHA G GL    L  +   Q+L+  L
Sbjct: 839  -SSLASNRLK---------------IALQNLEICFHAEGCGLPPKALHTAT-FQALQRDL 881

Query: 1392 SLYTQTTDTLIKTFVRSQTTQ-GSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDL 1450
             L   ++  LI+ +  S+  Q      + +G V+++          E K+ V++++A+ L
Sbjct: 882  ELQAASSRELIRKYFCSRIQQQAETTSEELGAVTVKASY----RASEQKLRVELLSASSL 937

Query: 1451 -KWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPESYE 1509
                + G   PFV++T+   H+  +     T+    +  P ++ETF FL+  E   ++  
Sbjct: 938  LPLDSNGSSDPFVQLTLEPRHEFPELAARETQKHKKDLHPLFDETFEFLVPAEPCRKAGA 997

Query: 1510 -LQICVKDYCFAREDRVLGLAVMPLRDVTAKGSC-------ACWCPLGRKIHMDETGLTI 1561
             L + V DY     D + G A +PLR+V                 PL    +    G  I
Sbjct: 998  CLLLTVLDYDTLGADDLEGEAFLPLREVPGLSGSEEPGEVPQTRLPL---TYPAPNGDPI 1054

Query: 1562 LRILSQRSNDEVAREFVKLK 1581
            L++L  R  D  A+ FV+L+
Sbjct: 1055 LQLLEGRKGDREAQVFVRLR 1074


>gi|15451914 BAI1-associated protein 3 [Homo sapiens]
          Length = 1187

 Score =  109 bits (273), Expect = 2e-23
 Identities = 213/1019 (20%), Positives = 379/1019 (37%), Gaps = 184/1019 (18%)

Query: 565  IFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPY 624
            +   ++ VF  +   H + ++ V+++        +  + ++V+ A+ L AKD  G SDPY
Sbjct: 165  LLSYLQQVFGTSLEEHTEAIERVRKAKAP-----TYALKVSVMRAKNLLAKDPNGFSDPY 219

Query: 625  VTVQV--------------------SKTKKR-----------TKTIFGNLNPVWEEKFHF 653
              + +                     K  KR           T+     LNPVW+E F F
Sbjct: 220  CMLGILPASDATREPRAQKEQRFGFRKGSKRGGPLPAKCIQVTEVKSSTLNPVWKEHFLF 279

Query: 654  ECHN-SSDRIKVRVWDEDDDIK------------------SRVKQRLKR----------- 683
            E  + S+D++ + +WD DDD+                      KQ +K            
Sbjct: 280  EIEDVSTDQLHLDIWDHDDDVSLVEACRKLNEVIGLKGMGRYFKQIVKSARANGTAGPTE 339

Query: 684  -ESDDFLGQTIIEVRTLS-GEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHV 741
              +DDFLG   I VR +    +D W+ LE R+  S V G   L + +     +       
Sbjct: 340  DHTDDFLGCLNIPVREVPVAGVDRWFKLEPRSSASRVQGHCHLVLKLITTQRDTAMSQRG 399

Query: 742  QYTCL-HENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVDEFAMRYGIESIYQ 800
            +   L H  L  +L  ++ S      E     +W+      A  I+     +  +  +  
Sbjct: 400  RSGFLSHLLLLSHLLRLEHSA-----EEPNSSSWRGELSTPAATILCLHGAQSNLSPLQL 454

Query: 801  AMTHFACLSSKYM-CPGVPAVMSTLLANINAYYAHTTA---STNVSASDRFAA-SNFGKE 855
            A+ H+   S  +  C    + +  LL ++ A++    +       S +D  +A S FG  
Sbjct: 455  AVLHWQVSSRHHQTCTLDYSYLLGLLEDMQAHWEEAPSLPQEQEESLADSLSAFSEFG-- 512

Query: 856  RFVKLLDQLHNSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPR 915
              ++LL QL           R+ FPA +   +  L+  +  L  +  F+      +  P 
Sbjct: 513  --LQLLRQL-----------RDYFPATNSTAVHRLELLLKCLGKLQLFQ---PSFEICPF 556

Query: 916  ASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDFWPKLITLI 975
             S++  D   A      E+        Y R   L  + P E+ GP        P L+ L 
Sbjct: 557  ESELNMDIAAALKRGNREW--------YDRI--LNDKSPREQPGPQRL-----PGLVVLA 601

Query: 976  VSIIEEDKNSYTPVLNQFPQELNVG--KVSAEVMWHLFAQDMKYALEE-HEKDHLCKSAD 1032
             ++ ++ +  Y+   + F   LNV    ++   +  L A++     EE   K  L  ++ 
Sbjct: 602  DAVYDDLQFCYSVYASLFHSILNVDVFTLTFRQLERLVAEEAWVLTEELSPKMTLEVASG 661

Query: 1033 YMNLHFKVKWLHNEY-------VRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLR 1085
               L+  +  L   +        R L +     P  PA     V  W     D +   L+
Sbjct: 662  LFELYLTLADLQRFWDSIPGRDSRSLALAGIHAPFLPA-----VKLWFQVLRDQAKWRLQ 716

Query: 1086 GALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTI 1145
            GA++ D  +    +S H   S S       L+   E+  +L  PDP+       +  + +
Sbjct: 717  GAVDMDTLEPVDASSRH---SSSAATAGLCLSHIQELWVRLAWPDPAQAQGLGTQLGQDV 773

Query: 1146 GKVLMQYADILSKDFPAY------CTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLE 1199
             +  + Y ++L K              E L C+++NNV+ +R    +  + +   E    
Sbjct: 774  CEATLFYTELLRKKVDTQPGAAGEAVSEAL-CVVLNNVELVRKAAGQALKGLAWPEGATG 832

Query: 1200 AADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQMADILGQVRGTGNASPDARASAA 1259
                L    +     LD+      ++    +    + + DI   V+   + SPD+  +  
Sbjct: 833  PEGVLPRPLLSCTQALDDDLQREAHTVTAHLTS--KMVGDIRKYVQHI-SLSPDSIQN-- 887

Query: 1260 QDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGT 1319
               D  + PLM +LD  L L      K  L RVL+ LW +++  + + +           
Sbjct: 888  ---DEAVAPLMKYLDEKLALLNASLVKGNLSRVLEALWELLLQAILQAL----------- 933

Query: 1320 QLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLE 1379
                                     R+++    +     L+ +  +FHA G GL    L 
Sbjct: 934  ----------------------GANRDVSADFYSRFHFTLEALVSFFHAEGQGLPLESL- 970

Query: 1380 KSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVDDPVGEVSIQVDLFTHPGTGEHK 1439
            +    + L+  L L+  +T   I+ F   +  Q +   +  G +S++     H    E +
Sbjct: 971  RDGSYKRLKEELRLHKCSTRECIEQFYLDKLKQRTLEQNRFGRLSVR----CHYEAAEQR 1026

Query: 1440 VTVKVVAAND-LKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHF 1497
            + V+V+ A D L     G+  PFV V +  PH     R   T+ K+    P Y+E F+F
Sbjct: 1027 LAVEVLHAADLLPLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKTRTLHPVYDELFYF 1085



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 12/82 (14%)

Query: 601  KITITVVCAQGLQAKDKTGSSDPYVTVQVSKT-------KKRTKTIFGNLNPVWEEKFHF 653
            ++ + V+ A  L   D  G SDP+V V++           +RT+     L+PV++E F+F
Sbjct: 1026 RLAVEVLHAADLLPLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKTRTLHPVYDELFYF 1085

Query: 654  E-----CHNSSDRIKVRVWDED 670
                  C   +  +   V D D
Sbjct: 1086 SVPAEACRRRAACVLFTVMDHD 1107


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 64/266 (24%), Positives = 104/266 (39%), Gaps = 58/266 (21%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCK 537
           H F       PT+C  C   +WGI +QG++C  C    H +C + +  +C          
Sbjct: 36  HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC---------- 85

Query: 538 HGAEDRTQNIIMAMKDRMKIRERNKPEIFE--------------------------VIRD 571
            GA    Q      K + ++   + P   +                           +R 
Sbjct: 86  PGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRS 145

Query: 572 VFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQV-- 629
           V ++    H ++   ++  +   T+    +I +TV  A+ L   D  G SDPYV +++  
Sbjct: 146 VPSLCGVDHTERRGRLQLEIRAPTAD---EIHVTVGEARNLIPMDPNGLSDPYVKLKLIP 202

Query: 630 ---SKTKKRTKTIFGNLNPVWEEKFHFECH--NSSDRIKVRVWDEDDDIKSRVKQRLKRE 684
              + TK++T+T+   LNPVW E F F     +   R+ V VWD D           +  
Sbjct: 203 DPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWD-----------RTS 251

Query: 685 SDDFLGQTIIEV-RTLSGEMDVWYNL 709
            +DF+G     V   L   +D WY L
Sbjct: 252 RNDFMGAMSFGVSELLKAPVDGWYKL 277


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 64/262 (24%), Positives = 104/262 (39%), Gaps = 51/262 (19%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCK 537
           H F       PT+C  C   +WG  +QG +C  C    H++C + +   C          
Sbjct: 37  HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---------- 86

Query: 538 HGAEDRTQNIIMAMKDRMKIRERNKPEIFE----VIRDVFTVNKAAHVQQMKTVKQSVLD 593
            GA+    +     K + KI   + P   +    ++  +           M   K+ V++
Sbjct: 87  PGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146

Query: 594 -----GTSKWSAK-------------ITITVVCAQGLQAKDKTGSSDPYVTVQV-----S 630
                GT     +             + + V  A+ L   D  G SDPYV +++     S
Sbjct: 147 VPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

Query: 631 KTKKRTKTIFGNLNPVWEEKFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRLKRESDDF 688
           ++K++TKTI  +LNP W E F F+   S    R+ V +WD   D+ SR         +DF
Sbjct: 207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDW--DLTSR---------NDF 255

Query: 689 LGQTIIEVRTL-SGEMDVWYNL 709
           +G     +  L    +D W+ L
Sbjct: 256 MGSLSFGISELQKASVDGWFKL 277



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 22/82 (26%), Positives = 41/82 (50%), Gaps = 4/82 (4%)

Query: 1446 AANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGP 1505
            A N +     G+  P+V++ ++   +S+ K+K  T   S N  P++NETF F L  +E  
Sbjct: 180  AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLN--PEWNETFRFQL--KESD 235

Query: 1506 ESYELQICVKDYCFAREDRVLG 1527
            +   L + + D+     +  +G
Sbjct: 236  KDRRLSVEIWDWDLTSRNDFMG 257


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 64/262 (24%), Positives = 104/262 (39%), Gaps = 51/262 (19%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCK 537
           H F       PT+C  C   +WG  +QG +C  C    H++C + +   C          
Sbjct: 37  HKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---------- 86

Query: 538 HGAEDRTQNIIMAMKDRMKIRERNKPEIFE----VIRDVFTVNKAAHVQQMKTVKQSVLD 593
            GA+    +     K + KI   + P   +    ++  +           M   K+ V++
Sbjct: 87  PGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMN 146

Query: 594 -----GTSKWSAK-------------ITITVVCAQGLQAKDKTGSSDPYVTVQV-----S 630
                GT     +             + + V  A+ L   D  G SDPYV +++     S
Sbjct: 147 VPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

Query: 631 KTKKRTKTIFGNLNPVWEEKFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRLKRESDDF 688
           ++K++TKTI  +LNP W E F F+   S    R+ V +WD   D+ SR         +DF
Sbjct: 207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDW--DLTSR---------NDF 255

Query: 689 LGQTIIEVRTL-SGEMDVWYNL 709
           +G     +  L    +D W+ L
Sbjct: 256 MGSLSFGISELQKASVDGWFKL 277



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 22/82 (26%), Positives = 41/82 (50%), Gaps = 4/82 (4%)

Query: 1446 AANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGP 1505
            A N +     G+  P+V++ ++   +S+ K+K  T   S N  P++NETF F L  +E  
Sbjct: 180  AKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLN--PEWNETFRFQL--KESD 235

Query: 1506 ESYELQICVKDYCFAREDRVLG 1527
            +   L + + D+     +  +G
Sbjct: 236  KDRRLSVEIWDWDLTSRNDFMG 257


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 66/262 (25%), Positives = 98/262 (37%), Gaps = 51/262 (19%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCK 537
           H F       PT+C  C   +WG  +QG +C  C    H++C + +   C          
Sbjct: 37  HKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC---------- 86

Query: 538 HGAEDRTQNIIMAMKDRMKIRERNKPEIFE----VIRDVFTVNKAAHVQQMKTVKQSVL- 592
            GA+          K + KI     P   +    ++  +           M   KQ V+ 
Sbjct: 87  PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVIN 146

Query: 593 -------DGTSKWSA----------KITITVVCAQGLQAKDKTGSSDPYVTVQV-----S 630
                  D T K             K+ +TV  A+ L   D  G SDPYV +++     +
Sbjct: 147 VPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKN 206

Query: 631 KTKKRTKTIFGNLNPVWEEKFHFECHNSSD--RIKVRVWDEDDDIKSRVKQRLKRESDDF 688
           ++K++TKTI   LNP W E F F+   S    R+ V +WD D           +   +DF
Sbjct: 207 ESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWD-----------RTTRNDF 255

Query: 689 LGQTIIEVRTL-SGEMDVWYNL 709
           +G     V  L       WY L
Sbjct: 256 MGSLSFGVSELMKMPASGWYKL 277


>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
           sapiens]
          Length = 762

 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 27/55 (49%), Positives = 39/55 (70%)

Query: 477 PHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRA 531
           PHNF+  T   PT+C  C G LWG+ +QG RC +CG+ CH++C+DL+  +C +RA
Sbjct: 506 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA 560


>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
           sapiens]
          Length = 797

 Score = 74.7 bits (182), Expect = 7e-13
 Identities = 27/55 (49%), Positives = 39/55 (70%)

Query: 477 PHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRA 531
           PHNF+  T   PT+C  C G LWG+ +QG RC +CG+ CH++C+DL+  +C +RA
Sbjct: 541 PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRA 595


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 30/65 (46%), Positives = 39/65 (60%), Gaps = 2/65 (3%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADC--LQRAAEKS 535
           HNF+  T   PT+C  C G LWGI +QG +C +CG  CH++C+DLL   C    RA   S
Sbjct: 495 HNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLS 554

Query: 536 CKHGA 540
             HG+
Sbjct: 555 SGHGS 559


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 30/65 (46%), Positives = 39/65 (60%), Gaps = 2/65 (3%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADC--LQRAAEKS 535
           HNF+  T   PT+C  C G LWGI +QG +C +CG  CH++C+DLL   C    RA   S
Sbjct: 495 HNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLS 554

Query: 536 CKHGA 540
             HG+
Sbjct: 555 SGHGS 559


>gi|7662334 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 2 [Homo sapiens]
          Length = 689

 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 30/65 (46%), Positives = 39/65 (60%), Gaps = 2/65 (3%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADC--LQRAAEKS 535
           HNF+  T   PT+C  C G LWGI +QG +C +CG  CH++C+DLL   C    RA   S
Sbjct: 494 HNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLS 553

Query: 536 CKHGA 540
             HG+
Sbjct: 554 SGHGS 558


>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
          Length = 673

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 513 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 570

Query: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 571 CRECGLCCHKHCRDQVKVECKKRPGAK 597


>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
           sapiens]
          Length = 576

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 416 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 473

Query: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 474 CRECGLCCHKHCRDQVKVECKKRPGAK 500


>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
           sapiens]
          Length = 484

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 324 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 381

Query: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 382 CRECGLCCHKHCRDQVKVECKKRPGAK 408


>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
           sapiens]
          Length = 639

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 479 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 536

Query: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 537 CRECGLCCHKHCRDQVKVECKKRPGAK 563


>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
           sapiens]
          Length = 604

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 444 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 501

Query: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 502 CRECGLCCHKHCRDQVKVECKKRPGAK 528


>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
           sapiens]
          Length = 581

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 421 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 478

Query: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 479 CRECGLCCHKHCRDQVKVECKKRPGAK 505


>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
           sapiens]
          Length = 659

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 31/87 (35%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 448 RTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMR 507
           R S   EEL  ++ + +  A+   +     H F   T   PT+C  C G LWG+ +QG R
Sbjct: 499 RGSFSREELTGYLLRAS--AICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYR 556

Query: 508 CSECGVKCHEKCQDLLNADCLQRAAEK 534
           C ECG+ CH+ C+D +  +C +R   K
Sbjct: 557 CRECGLCCHKHCRDQVKVECKKRPGAK 583


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
           sapiens]
          Length = 778

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 40/127 (31%), Positives = 63/127 (49%), Gaps = 11/127 (8%)

Query: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661
           + + V+ A+GL A D TG SDP+  V+++  +  T T++ NLNP W + F F   +    
Sbjct: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV 466

Query: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721
           ++V V+DED D            S DFLG+  I + ++       Y L+ +       G 
Sbjct: 467 LEVTVYDEDRD-----------RSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGV 515

Query: 722 IRLQISV 728
           I L+I V
Sbjct: 516 IYLEIDV 522



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 12/106 (11%)

Query: 598 WSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHN 657
           W   ++IT++  + L+A D  G SDPYV  ++   K ++K +   LNP W E+F F  + 
Sbjct: 247 WRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYE 306

Query: 658 S-SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGE 702
                I +  WD+D             + DDF+G+  +++  LS E
Sbjct: 307 ERGGVIDITAWDKD-----------AGKRDDFIGRCQVDLSALSRE 341



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 33/100 (33%), Positives = 54/100 (54%), Gaps = 12/100 (12%)

Query: 601 KITITVVCAQGLQAKDKTGSSDPYVTVQVS-KTKKRTKTIFGNLNPVWEEKFHFECHNSS 659
           ++ IT+   Q L A+D+ G+SDPYV  ++  K   R+K I  NLNPVWEEK      +  
Sbjct: 41  QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLR 100

Query: 660 DRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTL 699
           + + ++V+D D  ++           DDF+G   +++  L
Sbjct: 101 EPLYIKVFDYDFGLQ-----------DDFMGSAFLDLTQL 129


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
           sapiens]
          Length = 999

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 40/127 (31%), Positives = 63/127 (49%), Gaps = 11/127 (8%)

Query: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661
           + + V+ A+GL A D TG SDP+  V+++  +  T T++ NLNP W + F F   +    
Sbjct: 628 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV 687

Query: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721
           ++V V+DED D            S DFLG+  I + ++       Y L+ +       G 
Sbjct: 688 LEVTVYDEDRD-----------RSADFLGKVAIPLLSIQNGEQKAYVLKNKQLTGPTKGV 736

Query: 722 IRLQISV 728
           I L+I V
Sbjct: 737 IYLEIDV 743



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 12/106 (11%)

Query: 598 WSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHN 657
           W   ++IT++  + L+A D  G SDPYV  ++   K ++K +   LNP W E+F F  + 
Sbjct: 468 WRGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYE 527

Query: 658 S-SDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGE 702
                I +  WD+D             + DDF+G+  +++  LS E
Sbjct: 528 ERGGVIDITAWDKD-----------AGKRDDFIGRCQVDLSALSRE 562



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 33/100 (33%), Positives = 54/100 (54%), Gaps = 12/100 (12%)

Query: 601 KITITVVCAQGLQAKDKTGSSDPYVTVQVS-KTKKRTKTIFGNLNPVWEEKFHFECHNSS 659
           ++ IT+   Q L A+D+ G+SDPYV  ++  K   R+K I  NLNPVWEEK      +  
Sbjct: 262 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLR 321

Query: 660 DRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTL 699
           + + ++V+D D  ++           DDF+G   +++  L
Sbjct: 322 EPLYIKVFDYDFGLQ-----------DDFMGSAFLDLTQL 350


>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 25/63 (39%), Positives = 39/63 (61%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCK 537
           HNF+   +  P  C  C+ L+ GI +QG++C  CGV CH++C+D L+ +C +RA   S +
Sbjct: 499 HNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLE 558

Query: 538 HGA 540
             A
Sbjct: 559 GSA 561


>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 25/63 (39%), Positives = 39/63 (61%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCK 537
           HNF+   +  P  C  C+ L+ GI +QG++C  CGV CH++C+D L+ +C +RA   S +
Sbjct: 499 HNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLE 558

Query: 538 HGA 540
             A
Sbjct: 559 GSA 561


>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 25/63 (39%), Positives = 39/63 (61%)

Query: 478 HNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNADCLQRAAEKSCK 537
           HNF+   +  P  C  C+ L+ GI +QG++C  CGV CH++C+D L+ +C +RA   S +
Sbjct: 499 HNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLE 558

Query: 538 HGA 540
             A
Sbjct: 559 GSA 561


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 22/44 (50%), Positives = 31/44 (70%)

Query: 477 PHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQ 520
           PH F+V+   +PT+C  C  LLWG+ARQG++C  CG+  H +CQ
Sbjct: 231 PHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQ 274



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 3/62 (4%)

Query: 466 QALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQDLLNA 525
           QA ++ + C   H F       PT+C  C   +WG+ +QG +C +C    H+KC D + A
Sbjct: 151 QAKVHHVKC---HEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIA 207

Query: 526 DC 527
            C
Sbjct: 208 KC 209


>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
           sapiens]
          Length = 823

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 11/127 (8%)

Query: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661
           + + V+ A  L A D +G SDP+  +++   + +T T++ NLNP W + F F   +  D 
Sbjct: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570

Query: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721
           ++V V+DED D           +  DFLG+  I + ++       Y L+ +  + A  G 
Sbjct: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619

Query: 722 IRLQISV 728
           I L++ +
Sbjct: 620 IYLEMDL 626



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 26/76 (34%), Positives = 47/76 (61%), Gaps = 1/76 (1%)

Query: 596 SKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVS-KTKKRTKTIFGNLNPVWEEKFHFE 654
           S ++  +TI +   + L  +D+ G+SDPYV  +++ KT  ++K I+ NLNPVW+E     
Sbjct: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249

Query: 655 CHNSSDRIKVRVWDED 670
             +   +++V+V+D D
Sbjct: 250 IQSLDQKLRVKVYDRD 265



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 24/79 (30%), Positives = 46/79 (58%), Gaps = 12/79 (15%)

Query: 598 WSAKITITVVCAQGLQAKDKTGSS--DPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFEC 655
           W+  I+IT+     L+ K+ +G S  + +V +++   + ++KT+  + NP W+E+F F  
Sbjct: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406

Query: 656 HNSSDR---IKVRVWDEDD 671
           H  SDR   + + VW +D+
Sbjct: 407 HYFSDRMGILDIEVWGKDN 425


>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
           sapiens]
          Length = 878

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 11/127 (8%)

Query: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661
           + + V+ A  L A D +G SDP+  +++   + +T T++ NLNP W + F F   +  D 
Sbjct: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570

Query: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721
           ++V V+DED D           +  DFLG+  I + ++       Y L+ +  + A  G 
Sbjct: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619

Query: 722 IRLQISV 728
           I L++ +
Sbjct: 620 IYLEMDL 626



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 26/76 (34%), Positives = 47/76 (61%), Gaps = 1/76 (1%)

Query: 596 SKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVS-KTKKRTKTIFGNLNPVWEEKFHFE 654
           S ++  +TI +   + L  +D+ G+SDPYV  +++ KT  ++K I+ NLNPVW+E     
Sbjct: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249

Query: 655 CHNSSDRIKVRVWDED 670
             +   +++V+V+D D
Sbjct: 250 IQSLDQKLRVKVYDRD 265



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 24/79 (30%), Positives = 46/79 (58%), Gaps = 12/79 (15%)

Query: 598 WSAKITITVVCAQGLQAKDKTGSS--DPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFEC 655
           W+  I+IT+     L+ K+ +G S  + +V +++   + ++KT+  + NP W+E+F F  
Sbjct: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406

Query: 656 HNSSDR---IKVRVWDEDD 671
           H  SDR   + + VW +D+
Sbjct: 407 HYFSDRMGILDIEVWGKDN 425


>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
           sapiens]
          Length = 306

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 11/127 (8%)

Query: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661
           + + V+ A  L A D +G SDP+  +++   + +T T++ NLNP W + F F   +  D 
Sbjct: 99  LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 158

Query: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721
           ++V V+DED D           +  DFLG+  I + ++       Y L+ +  + A  G 
Sbjct: 159 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 207

Query: 722 IRLQISV 728
           I L++ +
Sbjct: 208 IYLEMDL 214


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,751,683
Number of Sequences: 37866
Number of extensions: 2875887
Number of successful extensions: 8781
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 136
Number of HSP's that attempted gapping in prelim test: 8143
Number of HSP's gapped (non-prelim): 649
length of query: 1591
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1475
effective length of database: 13,855,062
effective search space: 20436216450
effective search space used: 20436216450
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.