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Search of human proteins with 16751917
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16751917 trace amine associated receptor 8 [Homo sapiens]
(342 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16751917 trace amine associated receptor 8 [Homo sapiens] 687 0.0
gi|28173558 trace amine associated receptor 6 [Homo sapiens] 566 e-161
gi|110618256 trace amine associated receptor 9 [Homo sapiens] 491 e-139
gi|223633986 trace amine associated receptor 5 [Homo sapiens] 306 2e-83
gi|21264324 trace amine associated receptor 1 [Homo sapiens] 271 5e-73
gi|74275344 trace amine associated receptor 2 isoform 1 [Homo sa... 250 1e-66
gi|74275342 trace amine associated receptor 2 isoform 2 [Homo sa... 237 1e-62
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 170 2e-42
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 170 2e-42
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 170 2e-42
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 170 2e-42
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 170 2e-42
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 170 2e-42
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 169 4e-42
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 154 1e-37
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 154 1e-37
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 154 1e-37
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 154 1e-37
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 146 3e-35
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 144 1e-34
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 144 1e-34
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 143 3e-34
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 141 7e-34
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 140 1e-33
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 139 3e-33
gi|4503383 dopamine receptor D1 [Homo sapiens] 139 5e-33
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 135 4e-32
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 135 4e-32
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 135 4e-32
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 134 2e-31
>gi|16751917 trace amine associated receptor 8 [Homo sapiens]
Length = 342
Score = 687 bits (1773), Expect = 0.0
Identities = 342/342 (100%), Positives = 342/342 (100%)
Query: 1 MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFK 60
MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFK
Sbjct: 1 MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFK 60
Query: 61 QLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVL 120
QLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVL
Sbjct: 61 QLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVL 120
Query: 121 HLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELV 180
HLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELV
Sbjct: 121 HLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELV 180
Query: 181 SALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESS 240
SALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESS
Sbjct: 181 SALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESS 240
Query: 241 SESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAY 300
SESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAY
Sbjct: 241 SESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAY 300
Query: 301 YNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 342
YNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE
Sbjct: 301 YNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 342
>gi|28173558 trace amine associated receptor 6 [Homo sapiens]
Length = 345
Score = 566 bits (1458), Expect = e-161
Identities = 273/343 (79%), Positives = 303/343 (88%), Gaps = 1/343 (0%)
Query: 1 MTSNFSQPV-VQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHF 59
M+SN S V VQLCY +VNGSC++ P+SPGSRVILY F FG++LAVFGNLLVM S+LHF
Sbjct: 1 MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHF 60
Query: 60 KQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSV 119
KQLHSPTNFL+ASLACADFLVGVTVM FSMVRTVESCWYFG FCT H+CCDVAFCYSS+
Sbjct: 61 KQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSL 120
Query: 120 LHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEEL 179
HLCFI IDRYI VTDPLVY TKFTVSVSGICISVSWILPL YSGAVFYTGV DDGLEEL
Sbjct: 121 FHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGLEEL 180
Query: 180 VSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVES 239
ALNC+GGCQ +V+Q WVL DFL FFIPT +MIILY IFL+A++QA KIE T SK ES
Sbjct: 181 SDALNCIGGCQTVVNQNWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSKTES 240
Query: 240 SSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSA 299
SSESYK RVA+RERKAAKTLGVTV+AF+ISWLPY++D LIDAFMGF+TPA IYEICCW A
Sbjct: 241 SSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCWCA 300
Query: 300 YYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 342
YYNSAMNPLIYALFYPWFRKAIK+I++G VLK SS+T++LF E
Sbjct: 301 YYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNSSATMNLFSE 343
>gi|110618256 trace amine associated receptor 9 [Homo sapiens]
Length = 348
Score = 491 bits (1265), Expect = e-139
Identities = 232/343 (67%), Positives = 279/343 (81%), Gaps = 1/343 (0%)
Query: 1 MTSNFSQP-VVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHF 59
M +NFSQ V+LCY++VN SCI+TPYSPG R ILY FG++LA FGNLLVM ++LHF
Sbjct: 1 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF 60
Query: 60 KQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSV 119
KQLH+PTNFLIASLACADFLVGVTVM FS VR+VESCWYFG +C H+C D +FC++S+
Sbjct: 61 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL 120
Query: 120 LHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEEL 179
HLC I +DRYI VTDPL Y TKFTVSVSGICI +SW +TYS ++FYTG N++G+EEL
Sbjct: 121 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL 180
Query: 180 VSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVES 239
V AL CVGGCQ ++Q WVL+ FLLFFIP + M+ +YSKIFL+AK QA KIE+T+S+ +S
Sbjct: 181 VVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQS 240
Query: 240 SSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSA 299
SSESYK RVAKRERKAAKTLG+ + AF++SWLPY VD +IDA+M F+TP Y+YEI W
Sbjct: 241 SSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCV 300
Query: 300 YYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 342
YYNSAMNPLIYA FY WF KAIKLI+SG VL+ SST +LF E
Sbjct: 301 YYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSE 343
>gi|223633986 trace amine associated receptor 5 [Homo sapiens]
Length = 337
Score = 306 bits (783), Expect = 2e-83
Identities = 146/330 (44%), Positives = 215/330 (65%), Gaps = 9/330 (2%)
Query: 13 CYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIAS 72
CY+ VNGSC T ++ G ++++Y A + G L+ V GN+ V +V +FK LH+PTNFL+ S
Sbjct: 17 CYQ-VNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKALHTPTNFLLLS 75
Query: 73 LACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIV 132
LA AD +G+ V+ S +R+VESCW+FG C LH+ D FC +S+ HLCFI IDR+
Sbjct: 76 LALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCA 135
Query: 133 VTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQII 192
+ DPL+Y +KFTV V+ I W +P Y+ YT V + L + + + CVG CQ++
Sbjct: 136 ICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEMPCVGSCQLL 195
Query: 193 VSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAKRE 252
+++ W ++F LFF+P L+MI LY KIF++A +QA +I T S + + AK E
Sbjct: 196 LNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLAGA--------AKHE 247
Query: 253 RKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYAL 312
RKAAKTLG+ V +++ WLP+T+D ++D+ + F+TP +++I W AY+NSA NP+IY
Sbjct: 248 RKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIYVF 307
Query: 313 FYPWFRKAIKLILSGDVLKASSSTISLFLE 342
Y WFRKA+KL LS V + T+ L+ E
Sbjct: 308 SYQWFRKALKLTLSQKVFSPQTRTVDLYQE 337
>gi|21264324 trace amine associated receptor 1 [Homo sapiens]
Length = 339
Score = 271 bits (694), Expect = 5e-73
Identities = 133/336 (39%), Positives = 201/336 (59%), Gaps = 2/336 (0%)
Query: 9 VVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNF 68
++ C+ +N SC++ +S R LY+ L + GNL+V+ S+ HFKQLH+PTN+
Sbjct: 1 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW 60
Query: 69 LIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICID 128
LI S+A DFL+G VM +SMVR+ E CWYFG FC +H+ D+ +S+ HL FI ID
Sbjct: 61 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID 120
Query: 129 RYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEEL-VSALNCVG 187
RY V DPL Y K + V + I +SW +P ++ + + +N G EE+ ++C G
Sbjct: 121 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG 180
Query: 188 GCQIIVSQ-GWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKI 246
GC + S+ VL F+IP +M+ +Y +I+LIAK+QA I + K++ E
Sbjct: 181 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG 240
Query: 247 RVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMN 306
+ERKA KTLG+ + F+I W P+ + ++D F+ ++ P + ++ W Y NS N
Sbjct: 241 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN 300
Query: 307 PLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 342
P++YA FYPWFRKA+K++L G + + SS LFLE
Sbjct: 301 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLE 336
>gi|74275344 trace amine associated receptor 2 isoform 1 [Homo
sapiens]
Length = 351
Score = 250 bits (639), Expect = 1e-66
Identities = 120/321 (37%), Positives = 187/321 (58%), Gaps = 9/321 (2%)
Query: 13 CYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIAS 72
C E N SC E S G RV +Y+ + + +FGNL ++ S+ +FKQLH+PTNFLI S
Sbjct: 25 CSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILS 84
Query: 73 LACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIV 132
+A DFL+G T+M +SM+R+VE+CWYFG FC ++ D+ +S+ HLC + IDR+
Sbjct: 85 MAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYA 144
Query: 133 VTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQII 192
+ PL+Y+TK T+ V + + W +P ++ V ++ DG+E + C C ++
Sbjct: 145 ICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVM 204
Query: 193 VSQGWVLIDFLL-FFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAKR 251
++ W F+ FF P +M+ +Y KIF ++++ A I + K+
Sbjct: 205 FNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQ--------VKK 256
Query: 252 ERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYA 311
++KAAKTLG+ + F++ W P IL+D F+ F TP +++ W Y+NS NPLIY
Sbjct: 257 DKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYG 316
Query: 312 LFYPWFRKAIKLILSGDVLKA 332
FYPWFR+A+K IL G + +
Sbjct: 317 FFYPWFRRALKYILLGKIFSS 337
>gi|74275342 trace amine associated receptor 2 isoform 2 [Homo
sapiens]
Length = 306
Score = 237 bits (604), Expect = 1e-62
Identities = 112/298 (37%), Positives = 178/298 (59%), Gaps = 10/298 (3%)
Query: 37 AFSFGSL-LAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVES 95
+F GS+ + +FGNL ++ S+ +FKQLH+PTNFLI S+A DFL+G T+M +SM+R+VE+
Sbjct: 3 SFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVEN 62
Query: 96 CWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVS 155
CWYFG FC ++ D+ +S+ HLC + IDR+ + PL+Y+TK T+ V + +
Sbjct: 63 CWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLC 122
Query: 156 WILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLL-FFIPTLVMII 214
W +P ++ V ++ DG+E + C C ++ ++ W F+ FF P +M+
Sbjct: 123 WSVPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVG 182
Query: 215 LYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYT 274
+Y KIF ++++ A I + K+++KAAKTLG+ + F++ W P
Sbjct: 183 IYGKIFAVSRKHAHAINNLRENQNNQ--------VKKDKKAAKTLGIVIGVFLLCWFPCF 234
Query: 275 VDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKA 332
IL+D F+ F TP +++ W Y+NS NPLIY FYPWFR+A+K IL G + +
Sbjct: 235 FTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSS 292
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 170 bits (430), Expect = 2e-42
Identities = 101/320 (31%), Positives = 161/320 (50%), Gaps = 14/320 (4%)
Query: 23 ETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHS-PTNFLIASLACADFLVG 81
E + +V+L T S L+A+ GNLLVM +V +QL TN+ I SLA AD LV
Sbjct: 11 EEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS 70
Query: 82 VTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV-TDPLVYA 140
V VM F + V+ W +G FC + + DV +S+ HLC I +DRY + PLVY
Sbjct: 71 VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYR 130
Query: 141 TKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGG-----CQIIVSQ 195
K T + + W++P S G N+ G+ +L+ C +V++
Sbjct: 131 NKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK 190
Query: 196 GW-VLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIE------TTSSKVESSSESYKIRV 248
+ + + F+IP L+M++ Y +I++ AK+ A +I+ +S S++ +
Sbjct: 191 PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHR 250
Query: 249 AKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPL 308
+ E KAAKTL + + F + W P+ V ++D F+ + P ++ W Y NS +NP
Sbjct: 251 MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPF 310
Query: 309 IYALFYPWFRKAIKLILSGD 328
+YA FR+A +IL D
Sbjct: 311 LYAFLNKSFRRAFLIILCCD 330
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 170 bits (430), Expect = 2e-42
Identities = 101/320 (31%), Positives = 161/320 (50%), Gaps = 14/320 (4%)
Query: 23 ETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHS-PTNFLIASLACADFLVG 81
E + +V+L T S L+A+ GNLLVM +V +QL TN+ I SLA AD LV
Sbjct: 11 EEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS 70
Query: 82 VTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV-TDPLVYA 140
V VM F + V+ W +G FC + + DV +S+ HLC I +DRY + PLVY
Sbjct: 71 VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYR 130
Query: 141 TKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGG-----CQIIVSQ 195
K T + + W++P S G N+ G+ +L+ C +V++
Sbjct: 131 NKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK 190
Query: 196 GW-VLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIE------TTSSKVESSSESYKIRV 248
+ + + F+IP L+M++ Y +I++ AK+ A +I+ +S S++ +
Sbjct: 191 PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHR 250
Query: 249 AKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPL 308
+ E KAAKTL + + F + W P+ V ++D F+ + P ++ W Y NS +NP
Sbjct: 251 MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPF 310
Query: 309 IYALFYPWFRKAIKLILSGD 328
+YA FR+A +IL D
Sbjct: 311 LYAFLNKSFRRAFLIILCCD 330
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 170 bits (430), Expect = 2e-42
Identities = 101/320 (31%), Positives = 161/320 (50%), Gaps = 14/320 (4%)
Query: 23 ETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHS-PTNFLIASLACADFLVG 81
E + +V+L T S L+A+ GNLLVM +V +QL TN+ I SLA AD LV
Sbjct: 11 EEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS 70
Query: 82 VTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV-TDPLVYA 140
V VM F + V+ W +G FC + + DV +S+ HLC I +DRY + PLVY
Sbjct: 71 VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYR 130
Query: 141 TKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGG-----CQIIVSQ 195
K T + + W++P S G N+ G+ +L+ C +V++
Sbjct: 131 NKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK 190
Query: 196 GW-VLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIE------TTSSKVESSSESYKIRV 248
+ + + F+IP L+M++ Y +I++ AK+ A +I+ +S S++ +
Sbjct: 191 PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHR 250
Query: 249 AKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPL 308
+ E KAAKTL + + F + W P+ V ++D F+ + P ++ W Y NS +NP
Sbjct: 251 MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPF 310
Query: 309 IYALFYPWFRKAIKLILSGD 328
+YA FR+A +IL D
Sbjct: 311 LYAFLNKSFRRAFLIILCCD 330
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 170 bits (430), Expect = 2e-42
Identities = 101/320 (31%), Positives = 161/320 (50%), Gaps = 14/320 (4%)
Query: 23 ETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHS-PTNFLIASLACADFLVG 81
E + +V+L T S L+A+ GNLLVM +V +QL TN+ I SLA AD LV
Sbjct: 11 EEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS 70
Query: 82 VTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV-TDPLVYA 140
V VM F + V+ W +G FC + + DV +S+ HLC I +DRY + PLVY
Sbjct: 71 VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYR 130
Query: 141 TKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGG-----CQIIVSQ 195
K T + + W++P S G N+ G+ +L+ C +V++
Sbjct: 131 NKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK 190
Query: 196 GW-VLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIE------TTSSKVESSSESYKIRV 248
+ + + F+IP L+M++ Y +I++ AK+ A +I+ +S S++ +
Sbjct: 191 PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHR 250
Query: 249 AKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPL 308
+ E KAAKTL + + F + W P+ V ++D F+ + P ++ W Y NS +NP
Sbjct: 251 MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPF 310
Query: 309 IYALFYPWFRKAIKLILSGD 328
+YA FR+A +IL D
Sbjct: 311 LYAFLNKSFRRAFLIILCCD 330
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 170 bits (430), Expect = 2e-42
Identities = 101/320 (31%), Positives = 161/320 (50%), Gaps = 14/320 (4%)
Query: 23 ETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHS-PTNFLIASLACADFLVG 81
E + +V+L T S L+A+ GNLLVM +V +QL TN+ I SLA AD LV
Sbjct: 11 EEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS 70
Query: 82 VTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV-TDPLVYA 140
V VM F + V+ W +G FC + + DV +S+ HLC I +DRY + PLVY
Sbjct: 71 VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYR 130
Query: 141 TKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGG-----CQIIVSQ 195
K T + + W++P S G N+ G+ +L+ C +V++
Sbjct: 131 NKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK 190
Query: 196 GW-VLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIE------TTSSKVESSSESYKIRV 248
+ + + F+IP L+M++ Y +I++ AK+ A +I+ +S S++ +
Sbjct: 191 PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHR 250
Query: 249 AKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPL 308
+ E KAAKTL + + F + W P+ V ++D F+ + P ++ W Y NS +NP
Sbjct: 251 MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPF 310
Query: 309 IYALFYPWFRKAIKLILSGD 328
+YA FR+A +IL D
Sbjct: 311 LYAFLNKSFRRAFLIILCCD 330
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 170 bits (430), Expect = 2e-42
Identities = 101/320 (31%), Positives = 161/320 (50%), Gaps = 14/320 (4%)
Query: 23 ETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHS-PTNFLIASLACADFLVG 81
E + +V+L T S L+A+ GNLLVM +V +QL TN+ I SLA AD LV
Sbjct: 11 EEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS 70
Query: 82 VTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV-TDPLVYA 140
V VM F + V+ W +G FC + + DV +S+ HLC I +DRY + PLVY
Sbjct: 71 VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYR 130
Query: 141 TKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGG-----CQIIVSQ 195
K T + + W++P S G N+ G+ +L+ C +V++
Sbjct: 131 NKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNK 190
Query: 196 GW-VLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIE------TTSSKVESSSESYKIRV 248
+ + + F+IP L+M++ Y +I++ AK+ A +I+ +S S++ +
Sbjct: 191 PYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHR 250
Query: 249 AKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPL 308
+ E KAAKTL + + F + W P+ V ++D F+ + P ++ W Y NS +NP
Sbjct: 251 MRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPF 310
Query: 309 IYALFYPWFRKAIKLILSGD 328
+YA FR+A +IL D
Sbjct: 311 LYAFLNKSFRRAFLIILCCD 330
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 169 bits (427), Expect = 4e-42
Identities = 104/334 (31%), Positives = 164/334 (49%), Gaps = 28/334 (8%)
Query: 23 ETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHS-PTNFLIASLACADFLVG 81
E + +V+L T S L+A+ GNLLVM +V +QL TN+ I SLA AD LV
Sbjct: 11 EEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVS 70
Query: 82 VTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV-TDPLVYA 140
V VM F + V+ W +G FC + + DV +S+ HLC I +DRY + PLVY
Sbjct: 71 VLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYR 130
Query: 141 TKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGG------------ 188
K T + + W++P S G N+ G+ +L +LN G
Sbjct: 131 NKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFN 190
Query: 189 -------CQIIVSQGW-VLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIE------TTS 234
C +V++ + + + F+IP L+M++ Y +I++ AK+ A +I+ +S
Sbjct: 191 QNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASS 250
Query: 235 SKVESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEI 294
S++ + + E KAAKTL + + F + W P+ V ++D F+ + P ++
Sbjct: 251 ESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTA 310
Query: 295 CCWSAYYNSAMNPLIYALFYPWFRKAIKLILSGD 328
W Y NS +NP +YA FR+A +IL D
Sbjct: 311 FLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCD 344
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 154 bits (389), Expect = 1e-37
Identities = 104/339 (30%), Positives = 168/339 (49%), Gaps = 39/339 (11%)
Query: 18 NGSCIETPYSPG-SRVILYTAFSFGSLL-AVFGNLLVMTSVLHFKQLHSPTNFLIASLAC 75
+ +C + P S+ IL G +L V GN+LV+ SV + LHS T++ I +LA
Sbjct: 11 SSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAV 70
Query: 76 ADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTD 135
AD L+ TV+ FS + V W FG FC + + DV C +S++ LC I IDRYI V+
Sbjct: 71 ADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSY 130
Query: 136 PLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQ 195
PL Y T T + + W L L S + +E + CQI
Sbjct: 131 PLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETI--------CQINEEP 182
Query: 196 GWVLIDFL-LFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAK---- 250
G+VL L F++P +++++Y +++++AK+++ +++ +S SE +R+ +
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAP 242
Query: 251 -----------------------RERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLT 287
RE+KAAKTLG+ V FV+ WLP+ + + I +F
Sbjct: 243 AGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK 302
Query: 288 PA-YIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
P+ +++I W Y NS +NP+IY F+KA + +L
Sbjct: 303 PSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 154 bits (389), Expect = 1e-37
Identities = 104/339 (30%), Positives = 168/339 (49%), Gaps = 39/339 (11%)
Query: 18 NGSCIETPYSPG-SRVILYTAFSFGSLL-AVFGNLLVMTSVLHFKQLHSPTNFLIASLAC 75
+ +C + P S+ IL G +L V GN+LV+ SV + LHS T++ I +LA
Sbjct: 11 SSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAV 70
Query: 76 ADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTD 135
AD L+ TV+ FS + V W FG FC + + DV C +S++ LC I IDRYI V+
Sbjct: 71 ADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSY 130
Query: 136 PLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQ 195
PL Y T T + + W L L S + +E + CQI
Sbjct: 131 PLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETI--------CQINEEP 182
Query: 196 GWVLIDFL-LFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAK---- 250
G+VL L F++P +++++Y +++++AK+++ +++ +S SE +R+ +
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAP 242
Query: 251 -----------------------RERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLT 287
RE+KAAKTLG+ V FV+ WLP+ + + I +F
Sbjct: 243 AGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK 302
Query: 288 PA-YIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
P+ +++I W Y NS +NP+IY F+KA + +L
Sbjct: 303 PSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 154 bits (389), Expect = 1e-37
Identities = 104/339 (30%), Positives = 168/339 (49%), Gaps = 39/339 (11%)
Query: 18 NGSCIETPYSPG-SRVILYTAFSFGSLL-AVFGNLLVMTSVLHFKQLHSPTNFLIASLAC 75
+ +C + P S+ IL G +L V GN+LV+ SV + LHS T++ I +LA
Sbjct: 11 SSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAV 70
Query: 76 ADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTD 135
AD L+ TV+ FS + V W FG FC + + DV C +S++ LC I IDRYI V+
Sbjct: 71 ADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSY 130
Query: 136 PLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQ 195
PL Y T T + + W L L S + +E + CQI
Sbjct: 131 PLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETI--------CQINEEP 182
Query: 196 GWVLIDFL-LFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAK---- 250
G+VL L F++P +++++Y +++++AK+++ +++ +S SE +R+ +
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAP 242
Query: 251 -----------------------RERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLT 287
RE+KAAKTLG+ V FV+ WLP+ + + I +F
Sbjct: 243 AGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK 302
Query: 288 PA-YIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
P+ +++I W Y NS +NP+IY F+KA + +L
Sbjct: 303 PSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 154 bits (389), Expect = 1e-37
Identities = 104/339 (30%), Positives = 168/339 (49%), Gaps = 39/339 (11%)
Query: 18 NGSCIETPYSPG-SRVILYTAFSFGSLL-AVFGNLLVMTSVLHFKQLHSPTNFLIASLAC 75
+ +C + P S+ IL G +L V GN+LV+ SV + LHS T++ I +LA
Sbjct: 11 SSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAV 70
Query: 76 ADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTD 135
AD L+ TV+ FS + V W FG FC + + DV C +S++ LC I IDRYI V+
Sbjct: 71 ADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSY 130
Query: 136 PLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQ 195
PL Y T T + + W L L S + +E + CQI
Sbjct: 131 PLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETI--------CQINEEP 182
Query: 196 GWVLIDFL-LFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKIRVAK---- 250
G+VL L F++P +++++Y +++++AK+++ +++ +S SE +R+ +
Sbjct: 183 GYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAP 242
Query: 251 -----------------------RERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLT 287
RE+KAAKTLG+ V FV+ WLP+ + + I +F
Sbjct: 243 AGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFK 302
Query: 288 PA-YIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
P+ +++I W Y NS +NP+IY F+KA + +L
Sbjct: 303 PSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 146 bits (368), Expect = 3e-35
Identities = 90/301 (29%), Positives = 149/301 (49%), Gaps = 23/301 (7%)
Query: 43 LLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAK 102
L VFGN+LV+T++ F++L + TN+ I SLACAD ++G+ V+ F + W FG
Sbjct: 45 LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNF 104
Query: 103 FCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTY 162
+C + DV +S+ LC I +DRY +T P Y + T + + + I + WI+
Sbjct: 105 WCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIV---- 160
Query: 163 SGAVFYTGVNDDGLEEL-VSALNCVGG---CQIIVSQGWVLIDFLL-FFIPTLVMIILYS 217
SG + + A+NC C +Q + + ++ F++P ++M+ +YS
Sbjct: 161 SGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYS 220
Query: 218 KIFLIAKQQAIKIETTS--------SKVESSSES-----YKIRVAKRERKAAKTLGVTVL 264
++F AK+Q KI+ + S+VE + + +E KA KTLG+ +
Sbjct: 221 RVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMG 280
Query: 265 AFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLI 324
F + WLP+ + ++ L +Y + W Y NS NPLIY P FR A + +
Sbjct: 281 TFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQEL 339
Query: 325 L 325
L
Sbjct: 340 L 340
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 144 bits (362), Expect = 1e-34
Identities = 95/299 (31%), Positives = 148/299 (49%), Gaps = 13/299 (4%)
Query: 43 LLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAK 102
L+ V GN++V +V ++L + TN I SLA D L+G+ V+ FS + + W FG
Sbjct: 30 LITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKV 89
Query: 103 FCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTY 162
FC +++ DV C +S+L+L I +DRY V DPL Y T I + + W++ +T
Sbjct: 90 FCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITL 149
Query: 163 SGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLL-FFIPTLVMIILYSKIFL 221
S + G N E + C++ V++ + L+D L+ F++P L+M I Y +IF
Sbjct: 150 SFLSIHLGWN--SRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFK 207
Query: 222 IAKQQAIKIETTSSKVESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDA 281
+A+ QA +I SS ++ RE KA TL + AF+I W PY +
Sbjct: 208 VARDQAKRINHISSWKAATI---------REHKATVTLAAVMGAFIICWFPYFTAFVYRG 258
Query: 282 FMGFLTPAYIYE-ICCWSAYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISL 339
G + E I W Y NSA+NP++YA FR + + + +S SL
Sbjct: 259 LRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSL 317
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 144 bits (362), Expect = 1e-34
Identities = 95/299 (31%), Positives = 148/299 (49%), Gaps = 13/299 (4%)
Query: 43 LLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAK 102
L+ V GN++V +V ++L + TN I SLA D L+G+ V+ FS + + W FG
Sbjct: 30 LITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKV 89
Query: 103 FCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTY 162
FC +++ DV C +S+L+L I +DRY V DPL Y T I + + W++ +T
Sbjct: 90 FCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITL 149
Query: 163 SGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLL-FFIPTLVMIILYSKIFL 221
S + G N E + C++ V++ + L+D L+ F++P L+M I Y +IF
Sbjct: 150 SFLSIHLGWN--SRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFK 207
Query: 222 IAKQQAIKIETTSSKVESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDA 281
+A+ QA +I SS ++ RE KA TL + AF+I W PY +
Sbjct: 208 VARDQAKRINHISSWKAATI---------REHKATVTLAAVMGAFIICWFPYFTAFVYRG 258
Query: 282 FMGFLTPAYIYE-ICCWSAYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISL 339
G + E I W Y NSA+NP++YA FR + + + +S SL
Sbjct: 259 LRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSL 317
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 143 bits (360), Expect = 3e-34
Identities = 106/345 (30%), Positives = 164/345 (47%), Gaps = 60/345 (17%)
Query: 31 RVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMV 90
+V+L + +L N V+ +V ++LH+P N+LIASLA D LV + VM S +
Sbjct: 49 KVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTM 108
Query: 91 RTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGI 150
TV W G C D+ C +S+LHLC I +DRY +TD + Y+ K T + +
Sbjct: 109 YTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAV 168
Query: 151 CISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLLFFIPTL 210
I++ W+ ++ S F+ EE VS CV I+ + + F+ PTL
Sbjct: 169 MIALVWVFSISISLPPFFW--RQAKAEEEVS--ECVVNTDHILYTVYSTVG--AFYFPTL 222
Query: 211 VMIILYSKIFLIAKQQAIK-------------------------IETTSSKV-----ESS 240
++I LY +I++ A+ + +K + + +S+V ES
Sbjct: 223 LLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESG 282
Query: 241 SESY----KIRV-----------AKRERKAAKTLGVTVLAFVISWLPYTVDILI-----D 280
S Y K+RV A RERKA KTLG+ + AF++ WLP+ + L+ D
Sbjct: 283 SPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKD 342
Query: 281 AFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAI-KLI 324
A L I++ W Y NS +NP+IY + F++A KLI
Sbjct: 343 ACWFHLA---IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 141 bits (356), Expect = 7e-34
Identities = 95/315 (30%), Positives = 149/315 (47%), Gaps = 40/315 (12%)
Query: 43 LLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAK 102
L A+ GN+LV+ SV + L +PTN+ I +LA AD L+ TV+ FS V W G
Sbjct: 57 LFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRI 116
Query: 103 FCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTY 162
FC + + DV C +S+L LC I IDRYI V L Y T T + + + W+L
Sbjct: 117 FCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVI 176
Query: 163 SGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFL-LFFIPTLVMIILYSKIFL 221
S G +E A N C + + L L F+IP V++++Y ++++
Sbjct: 177 SIGPLL------GWKE--PAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYI 228
Query: 222 IAKQQAIKIETTSSKVESSSESYKIRVAK------------------------------R 251
+AK+ +E K S+S+ +R+ R
Sbjct: 229 VAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSR 288
Query: 252 ERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPA-YIYEICCWSAYYNSAMNPLIY 310
E+KAAKTLG+ V F++ WLP+ + + + + L P ++++ W Y+NS +NP+IY
Sbjct: 289 EKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIY 348
Query: 311 ALFYPWFRKAIKLIL 325
F++A IL
Sbjct: 349 PCSSKEFKRAFVRIL 363
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 140 bits (354), Expect = 1e-33
Identities = 102/342 (29%), Positives = 164/342 (47%), Gaps = 55/342 (16%)
Query: 31 RVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMV 90
++ L S +L V N V+T++L ++LH+P N+LI SLA D LV + VM S+
Sbjct: 38 KISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIA 97
Query: 91 RTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGI 150
T+ W FG C + D+ C +S+LHLC I +DRY +TD L Y+ + T +
Sbjct: 98 YTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAT 157
Query: 151 CISVSWILPLTYS-GAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLLFFIPT 209
I++ W + + S +F+ EE+ L V QI + + F+IP+
Sbjct: 158 MIAIVWAISICISIPPLFWRQAK--AQEEMSDCL--VNTSQISYT---IYSTCGAFYIPS 210
Query: 210 LVMIILYSKIFLIAKQQAI-------KIETTSSKVESSSES------------------- 243
+++IILY +I+ A+ + + K TT+ + S+ S
Sbjct: 211 VLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGS 270
Query: 244 ------YKIRV-----------AKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMG-- 284
KI++ A RERKA K LG+ + AF+I WLP+ V L+
Sbjct: 271 PLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDS 330
Query: 285 -FLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
++ PA +++ W Y NS +NP+IY +F FR+A + I+
Sbjct: 331 CWIHPA-LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 139 bits (351), Expect = 3e-33
Identities = 104/348 (29%), Positives = 160/348 (45%), Gaps = 59/348 (16%)
Query: 30 SRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSM 89
S++++ S +L+ N LV+ +++ ++LH P N+LI SLA DFLV V VM FS+
Sbjct: 22 SKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSI 81
Query: 90 VRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSG 149
V V W G C + D+ C S+LHL I +DRY +TD + YA K T +G
Sbjct: 82 VYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAG 141
Query: 150 ICISVSWILPLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLLFFIPT 209
I I++ WI+ + S + ++ C+ IVS + F F+IP
Sbjct: 142 IMITIVWIISVFISMPPLFWRHQGTSRDD-----ECIIKHDHIVST--IYSTFGAFYIPL 194
Query: 210 LVMIILYSKIF-----LIAKQQAIKI-----------ETTSSKVESSSESYKIRVA---- 249
+++ILY KI+ L K+QA +I E+ +S S SY + +
Sbjct: 195 ALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDP 254
Query: 250 -------------------------------KRERKAAKTLGVTVLAFVISWLPYTV-DI 277
RERKAA TLG+ + AFVI WLP+ V ++
Sbjct: 255 STDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKEL 314
Query: 278 LIDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
+++ + W Y NS +NPLIY +F F+KA + ++
Sbjct: 315 VVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLV 362
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 139 bits (349), Expect = 5e-33
Identities = 106/342 (30%), Positives = 163/342 (47%), Gaps = 38/342 (11%)
Query: 16 DVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSP-TNFLIASLA 74
D G +E +S R++ S L + GN LV +V+ F+ L S TNF + SLA
Sbjct: 10 DGTGLVVERDFSV--RILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLA 67
Query: 75 CADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVT 134
+D LV V VM + V + W FG+ FC + D+ +S+L+LC I +DRY ++
Sbjct: 68 VSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAIS 126
Query: 135 DPLVYATKFTVSVSGICISVSWIL-------PLTYSGAVFYTGVNDDGLEELVSALNCVG 187
P Y K T + I ISV+W L P+ S DG S +
Sbjct: 127 SPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDG--NATSLAETID 184
Query: 188 GCQIIVSQGWVLIDFLL-FFIPTLVMIILYSKIFLIAKQQAIKI-------------ETT 233
C +S+ + + ++ F+IP +MI+ Y++I+ IA++Q +I +TT
Sbjct: 185 NCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTT 244
Query: 234 SSK---VESSSESYKIRVA-KRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMG----- 284
+ VE S +++ KRE K KTL V + FV WLP+ + I F G
Sbjct: 245 TGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQ 304
Query: 285 -FLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
F + +++ W + NS++NP+IYA F FRKA +L
Sbjct: 305 PFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLL 345
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 135 bits (341), Expect = 4e-32
Identities = 103/347 (29%), Positives = 154/347 (44%), Gaps = 48/347 (13%)
Query: 15 EDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLA 74
++ +G + Y +V++ + + +LL + GN LV+ SV K+L P+N+LI SLA
Sbjct: 65 DNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLA 124
Query: 75 CADFLVGVTVMLF-SMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV 133
AD V V VM F S+ + W FG FC + DV C +S++ LC I IDRY+ +
Sbjct: 125 LADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI 184
Query: 134 TDPLVYATKFTVSVSGICISVSWILPLTYSGAVFY---TGVNDDGLEELVSALNCVGGCQ 190
T PL Y + I W+L + + + VNDD + C
Sbjct: 185 TRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV------------CL 232
Query: 191 IIVSQGWVLID-FLLFFIPTLVMIILYSKIFLIAKQQAIK-------------------I 230
I G+ + + F+IP VM+ +Y +I+ A++ A K I
Sbjct: 233 ISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGI 292
Query: 231 ETTSSKVESSS--------ESYKIRVAKRERKAAKTLGVTVLAFVISWLPY----TVDIL 278
+VE + E I + KRE+KAA TLG+ V AF + WLP+ T
Sbjct: 293 VKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPF 352
Query: 279 IDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
I P ++ W Y NS +NP IYA F R + +L
Sbjct: 353 ICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 135 bits (341), Expect = 4e-32
Identities = 103/347 (29%), Positives = 154/347 (44%), Gaps = 48/347 (13%)
Query: 15 EDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLA 74
++ +G + Y +V++ + + +LL + GN LV+ SV K+L P+N+LI SLA
Sbjct: 65 DNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLA 124
Query: 75 CADFLVGVTVMLF-SMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV 133
AD V V VM F S+ + W FG FC + DV C +S++ LC I IDRY+ +
Sbjct: 125 LADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI 184
Query: 134 TDPLVYATKFTVSVSGICISVSWILPLTYSGAVFY---TGVNDDGLEELVSALNCVGGCQ 190
T PL Y + I W+L + + + VNDD + C
Sbjct: 185 TRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV------------CL 232
Query: 191 IIVSQGWVLID-FLLFFIPTLVMIILYSKIFLIAKQQAIK-------------------I 230
I G+ + + F+IP VM+ +Y +I+ A++ A K I
Sbjct: 233 ISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGI 292
Query: 231 ETTSSKVESSS--------ESYKIRVAKRERKAAKTLGVTVLAFVISWLPY----TVDIL 278
+VE + E I + KRE+KAA TLG+ V AF + WLP+ T
Sbjct: 293 VKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPF 352
Query: 279 IDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
I P ++ W Y NS +NP IYA F R + +L
Sbjct: 353 ICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 135 bits (341), Expect = 4e-32
Identities = 103/347 (29%), Positives = 154/347 (44%), Gaps = 48/347 (13%)
Query: 15 EDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLA 74
++ +G + Y +V++ + + +LL + GN LV+ SV K+L P+N+LI SLA
Sbjct: 65 DNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLA 124
Query: 75 CADFLVGVTVMLF-SMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVV 133
AD V V VM F S+ + W FG FC + DV C +S++ LC I IDRY+ +
Sbjct: 125 LADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI 184
Query: 134 TDPLVYATKFTVSVSGICISVSWILPLTYSGAVFY---TGVNDDGLEELVSALNCVGGCQ 190
T PL Y + I W+L + + + VNDD + C
Sbjct: 185 TRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV------------CL 232
Query: 191 IIVSQGWVLID-FLLFFIPTLVMIILYSKIFLIAKQQAIK-------------------I 230
I G+ + + F+IP VM+ +Y +I+ A++ A K I
Sbjct: 233 ISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGI 292
Query: 231 ETTSSKVESSS--------ESYKIRVAKRERKAAKTLGVTVLAFVISWLPY----TVDIL 278
+VE + E I + KRE+KAA TLG+ V AF + WLP+ T
Sbjct: 293 VKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPF 352
Query: 279 IDAFMGFLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLIL 325
I P ++ W Y NS +NP IYA F R + +L
Sbjct: 353 ICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 134 bits (336), Expect = 2e-31
Identities = 91/318 (28%), Positives = 149/318 (46%), Gaps = 43/318 (13%)
Query: 43 LLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAK 102
L+AV GNLLV+ SV + L + TN+ I +LA AD L+ TV+ FS V W FG
Sbjct: 108 LMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRA 167
Query: 103 FCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTY 162
FC + + DV C +S+L LC I +DRY+ V L Y T + +++ W++ L
Sbjct: 168 FCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVV 227
Query: 163 SGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLL-FFIPTLVMIILYSKIFL 221
S G +E V C I G+ + + F++P V++++Y ++++
Sbjct: 228 SVGPLL------GWKEPVPPDERF--CGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYV 279
Query: 222 IAKQQAIKIET-------------------------------TSSKVESSSESYKIRVAK 250
+A+ +E S+K + S +R+ K
Sbjct: 280 VARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLK 339
Query: 251 --RERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAY-IYEICCWSAYYNSAMNP 307
RE+KAAKTL + V FV+ W P+ + + + L P+ ++++ W Y+NS +NP
Sbjct: 340 FSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNP 399
Query: 308 LIYALFYPWFRKAIKLIL 325
LIY F++A +L
Sbjct: 400 LIYPCSSREFKRAFLRLL 417
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.329 0.140 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,139,056
Number of Sequences: 37866
Number of extensions: 431334
Number of successful extensions: 2919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 432
Number of HSP's successfully gapped in prelim test: 270
Number of HSP's that attempted gapping in prelim test: 1520
Number of HSP's gapped (non-prelim): 897
length of query: 342
length of database: 18,247,518
effective HSP length: 103
effective length of query: 239
effective length of database: 14,347,320
effective search space: 3429009480
effective search space used: 3429009480
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.