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Search of human proteins with 167466264
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167466264 leucine rich repeat containing 18 [Homo sapiens]
(261 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167466264 leucine rich repeat containing 18 [Homo sapiens] 523 e-149
gi|61742786 leucine rich repeat and death domain containing prot... 92 6e-19
gi|61742784 leucine rich repeat and death domain containing prot... 92 6e-19
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 88 7e-18
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 86 4e-17
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 85 7e-17
gi|62241040 leucine rich repeat containing 8 family, member A [H... 85 7e-17
gi|187829877 leucine rich repeat containing 8 family, member A [... 85 7e-17
gi|187829871 leucine rich repeat containing 8 family, member A [... 85 7e-17
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 84 2e-16
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 84 2e-16
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 83 2e-16
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 83 3e-16
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 82 5e-16
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 82 6e-16
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 82 6e-16
gi|194394161 leucine rich repeat containing 57 [Homo sapiens] 82 6e-16
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 81 1e-15
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 80 2e-15
gi|45827729 scribble isoform b [Homo sapiens] 79 3e-15
gi|45827731 scribble isoform a [Homo sapiens] 79 3e-15
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 79 3e-15
gi|197333706 leucine rich repeat containing 8 family, member D [... 79 4e-15
gi|34222199 leucine rich repeat containing 8 family, member D [H... 79 4e-15
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 78 9e-15
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 78 9e-15
gi|238908508 leucine-rich repeat and death domain-containing pro... 77 2e-14
gi|4503743 flightless I homolog [Homo sapiens] 77 2e-14
gi|61742782 leucine rich repeat and death domain containing prot... 75 4e-14
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 73 2e-13
>gi|167466264 leucine rich repeat containing 18 [Homo sapiens]
Length = 261
Score = 523 bits (1347), Expect = e-149
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 1 MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRN 60
MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRN
Sbjct: 1 MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRN 60
Query: 61 LIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQL 120
LIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQL
Sbjct: 61 LIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQL 120
Query: 121 KNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP 180
KNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP
Sbjct: 121 KNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP 180
Query: 181 KPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNL 240
KPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNL
Sbjct: 181 KPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNRIKNMATTTPRKTIFPNL 240
Query: 241 ISPNSMAKDSWEDWRIRLTSS 261
ISPNSMAKDSWEDWRIRLTSS
Sbjct: 241 ISPNSMAKDSWEDWRIRLTSS 261
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 91.7 bits (226), Expect = 6e-19
Identities = 48/146 (32%), Positives = 87/146 (59%), Gaps = 2/146 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LDLS + T P C+L++ + L LS N + ++P+++ L +L + N + LP +
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
+G +++L L++S N L + LP E+ L ++ +NL N L S+P +L L+ L + L
Sbjct: 190 LGALSTLQRLDLSQNLLDT--LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVL 247
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177
H NLL ++P +++LP L +L+++ N
Sbjct: 248 HSNLLASVPADLARLPLLTRLDLRDN 273
Score = 64.3 bits (155), Expect = 1e-10
Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 28/185 (15%)
Query: 39 ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSL 98
+T P + L+ + LDLS N + +P + + + L L L N + +LPE++G + +L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 99 LYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNN 158
+L V++NRL ++P LGAL L + L NLL+
Sbjct: 174 TFLTVTHNRL-------------------------QTLPPALGALSTLQRLDLSQNLLDT 208
Query: 159 IPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRL---ENLYVVEEKDLCAACLRKCQ 215
+P I L L +LN+ N S + S+R L NL DL L
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 268
Query: 216 NARDN 220
+ RDN
Sbjct: 269 DLRDN 273
Score = 52.0 bits (123), Expect = 5e-07
Identities = 32/95 (33%), Positives = 55/95 (57%), Gaps = 2/95 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+RLDLS+ + T P I L + EL+L+ N ++ +P S++ ++LR L LHSN + +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIR 124
+ ++ L L++ +N+L LP EL +R
Sbjct: 257 ADLARLPLLTRLDLRDNQL--RDLPPELLDAPFVR 289
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 91.7 bits (226), Expect = 6e-19
Identities = 48/146 (32%), Positives = 87/146 (59%), Gaps = 2/146 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LDLS + T P C+L++ + L LS N + ++P+++ L +L + N + LP +
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
+G +++L L++S N L + LP E+ L ++ +NL N L S+P +L L+ L + L
Sbjct: 190 LGALSTLQRLDLSQNLLDT--LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVL 247
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177
H NLL ++P +++LP L +L+++ N
Sbjct: 248 HSNLLASVPADLARLPLLTRLDLRDN 273
Score = 64.3 bits (155), Expect = 1e-10
Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 28/185 (15%)
Query: 39 ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSL 98
+T P + L+ + LDLS N + +P + + + L L L N + +LPE++G + +L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 99 LYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNN 158
+L V++NRL ++P LGAL L + L NLL+
Sbjct: 174 TFLTVTHNRL-------------------------QTLPPALGALSTLQRLDLSQNLLDT 208
Query: 159 IPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRL---ENLYVVEEKDLCAACLRKCQ 215
+P I L L +LN+ N S + S+R L NL DL L
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRL 268
Query: 216 NARDN 220
+ RDN
Sbjct: 269 DLRDN 273
Score = 52.0 bits (123), Expect = 5e-07
Identities = 32/95 (33%), Positives = 55/95 (57%), Gaps = 2/95 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+RLDLS+ + T P I L + EL+L+ N ++ +P S++ ++LR L LHSN + +P
Sbjct: 197 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 256
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIR 124
+ ++ L L++ +N+L LP EL +R
Sbjct: 257 ADLARLPLLTRLDLRDNQL--RDLPPELLDAPFVR 289
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 88.2 bits (217), Expect = 7e-18
Identities = 60/199 (30%), Positives = 105/199 (52%), Gaps = 7/199 (3%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L ++ + + + P+ I L ++ L+L NL+ +PDS+++ + L LDL +N I LPES
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
IG + L L + N+L+ LP E+ LKN+ +++ N L+ +P + L L ++ +
Sbjct: 193 IGALLHLKDLWLDGNQLSE--LPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVI 250
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRL---ENLYVVEEKDLCA 208
NLL IP I KL KL L + +N + E+ +S+ L EN + K +
Sbjct: 251 SQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSI-- 308
Query: 209 ACLRKCQNARDNLNRIKNM 227
L+K N + N++ ++
Sbjct: 309 GKLKKLSNLNADRNKLVSL 327
Score = 82.8 bits (203), Expect = 3e-16
Identities = 51/148 (34%), Positives = 78/148 (52%), Gaps = 2/148 (1%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ LDL I P+ I L + +L L N + ++P I +NL LD+ N +++LP
Sbjct: 177 EELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLP 236
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
E I +TSL L +S N L + +P + +LK + + + N L +P +G + L E+
Sbjct: 237 EEISGLTSLTDLVISQNLLET--IPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTEL 294
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L +N L +P SI KL KL LN RN
Sbjct: 295 VLTENQLLTLPKSIGKLKKLSNLNADRN 322
Score = 82.4 bits (202), Expect = 4e-16
Identities = 61/200 (30%), Positives = 102/200 (51%), Gaps = 12/200 (6%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L+L + +T P + +L ++ELDL N I +P+SI +L+ L L N + +LP+
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
IG + +LL L+VS NRL LP E+ L ++ + + N L+++P +G LK+L + +
Sbjct: 216 IGNLKNLLCLDVSENRL--ERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKV 273
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENL------YVVEEKD 205
N L +P ++ + L +L + N +S I +++L NL V K+
Sbjct: 274 DQNRLTQLPEAVGECESLTELVLTENQLLTLPKS---IGKLKKLSNLNADRNKLVSLPKE 330
Query: 206 LCAACLRKCQNARDN-LNRI 224
+ C RDN L RI
Sbjct: 331 IGGCCSLTVFCVRDNRLTRI 350
Score = 79.0 bits (193), Expect = 4e-15
Identities = 47/146 (32%), Positives = 80/146 (54%), Gaps = 2/146 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LD+S+ + P+ I L+ + +L +S+NL+ IPD I K + L L + N + +LPE+
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
+G+ SL L ++ N+L + LP + +LK + +N N L S+P +G L +
Sbjct: 285 VGECESLTELVLTENQLLT--LPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCV 342
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177
DN L IP +S+ +L L++ N
Sbjct: 343 RDNRLTRIPAEVSQATELHVLDVAGN 368
Score = 76.6 bits (187), Expect = 2e-14
Identities = 52/148 (35%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
++L LS I P I + ELD+SRN I +IP+SIS + L+ D N + +LP
Sbjct: 62 RKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP 121
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
ES ++ +L L+V N ++ LP + L N+ ++ L N L +P +L L+ L E+
Sbjct: 122 ESFPELQNLTCLSV--NDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEEL 179
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L +N + N+P SI L LK L + N
Sbjct: 180 DLGNNEIYNLPESIGALLHLKDLWLDGN 207
Score = 73.6 bits (179), Expect = 2e-13
Identities = 49/158 (31%), Positives = 87/158 (55%), Gaps = 5/158 (3%)
Query: 43 PKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLN 102
P+ +L + +L LS N I+++P I+ F L LD+ N I ++PESI +L +
Sbjct: 52 PEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVAD 111
Query: 103 VSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVS 162
S N LT LP +L+N+ +++ L S+P +G L L + L +NLL +P S
Sbjct: 112 FSGNPLTR--LPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDS 169
Query: 163 ISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYV 200
+++L +L++L++ N ES I ++ L++L++
Sbjct: 170 LTQLRRLEELDLGNNEIYNLPES---IGALLHLKDLWL 204
Score = 44.3 bits (103), Expect = 1e-04
Identities = 28/90 (31%), Positives = 45/90 (50%), Gaps = 2/90 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L L++ + T PK I +L + L+ RN + +P I +L + N + ++P
Sbjct: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLK 121
+ Q T L L+V+ NRL LP+ L LK
Sbjct: 354 VSQATELHVLDVAGNRLLH--LPLSLTALK 381
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 85.5 bits (210), Expect = 4e-17
Identities = 54/177 (30%), Positives = 90/177 (50%), Gaps = 5/177 (2%)
Query: 28 GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
G ++ ++ + P + + S + LDLS NL+ IP S ++ + + + L N ++K
Sbjct: 212 GLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEK 271
Query: 88 LPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
+P I + TSL L + N L + L + L N+R ++L NHL P + ALK L
Sbjct: 272 VPRLICRWTSLHLLYLGNTGL--HRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLE 329
Query: 148 EVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEK 204
+GL DN + +P + L KLK L + N F E + S+ LE LY+ +++
Sbjct: 330 VLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVL---SLASLEKLYIGQDQ 383
Score = 70.5 bits (171), Expect = 1e-12
Identities = 51/174 (29%), Positives = 87/174 (50%), Gaps = 12/174 (6%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
+D S +T P I ++++E+ L N I +IP I + +N+R L L N + L +
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE--- 148
+G ++SL L++S N + S+ L V + L +R + L L +P + K LH
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSL-VVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLEL 146
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVE 202
+GL N L +P I KL+++ +KRN F E+F + L L +++
Sbjct: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQF------EVFPQELCVLYTLEIID 194
Score = 65.9 bits (159), Expect = 3e-11
Identities = 42/141 (29%), Positives = 66/141 (46%), Gaps = 2/141 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L L+ + PK I+ + + E+ L RN P + L +DL N I +PE
Sbjct: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
IG +T L +++N L LP L Q + ++L N L S+P + L+++ E+GL
Sbjct: 207 IGHLTGLQKFYMASNNLPV--LPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGL 264
Query: 152 HDNLLNNIPVSISKLPKLKKL 172
N L +P I + L L
Sbjct: 265 SGNRLEKVPRLICRWTSLHLL 285
Score = 63.9 bits (154), Expect = 1e-10
Identities = 44/175 (25%), Positives = 80/175 (45%), Gaps = 24/175 (13%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LDLS+ + P I L +++ L L N I ++P + L+ L L N PE
Sbjct: 308 LDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEE 367
Query: 92 IGQMTSLLYLNVSNNR-LTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH--- 147
+ + SL L + ++ +P +++L++++ + + NHL+ +P +LG++ L
Sbjct: 368 VLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLD 427
Query: 148 --------------------EVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKP 182
E+ L DNLL ++P ++ L LK L + NP +P
Sbjct: 428 CRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEP 482
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/153 (23%), Positives = 75/153 (49%), Gaps = 3/153 (1%)
Query: 30 KRLDLSKMGITTFPKCILR-LSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKL 88
+ L L + + P I + L ++ L L+ N ++ +P I LR + L N +
Sbjct: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180
Query: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
P+ + + +L +++ N++ +P E+ L ++ + N+L +P +L +L
Sbjct: 181 PQELCVLYTLEIIDLDENKI--GAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSV 238
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPK 181
+ L NLL++IP S ++L K+ ++ + N K
Sbjct: 239 LDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEK 271
Score = 42.7 bits (99), Expect = 3e-04
Identities = 21/77 (27%), Positives = 42/77 (54%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
K L + + P + + +++ LD NL++++PD+I + Q L+ L L N + LP
Sbjct: 401 KELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLP 460
Query: 90 ESIGQMTSLLYLNVSNN 106
E++ + +L L + +N
Sbjct: 461 ENLDSLVNLKVLTLMDN 477
Score = 33.1 bits (74), Expect = 0.25
Identities = 21/79 (26%), Positives = 36/79 (45%), Gaps = 3/79 (3%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LD + P I + + EL L NL+ +P+++ NL+ L L N +++ P+
Sbjct: 426 LDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKE 485
Query: 92 I---GQMTSLLYLNVSNNR 107
+ G YL + NR
Sbjct: 486 VCAEGNEAIWKYLKENRNR 504
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 84.7 bits (208), Expect = 7e-17
Identities = 49/147 (33%), Positives = 81/147 (55%)
Query: 31 RLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPE 90
+L LS +T P I L +++ L+ N I ++P IS Q L+ L+L N ++ LP
Sbjct: 44 QLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR 103
Query: 91 SIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVG 150
G + +L L+++ N L+ N LP L +RA+ L N + +P +G L +L +
Sbjct: 104 GFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILS 163
Query: 151 LHDNLLNNIPVSISKLPKLKKLNIKRN 177
L DN L ++P I +L +LK+L+I+ N
Sbjct: 164 LRDNDLISLPKEIGELTQLKELHIQGN 190
Score = 44.7 bits (104), Expect = 8e-05
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 2/89 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L + + + P L+ + L LS N +P I K L+ L L N + LP+
Sbjct: 116 LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE 175
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQL 120
IG++T L L++ NRLT LP EL L
Sbjct: 176 IGELTQLKELHIQGNRLTV--LPPELGNL 202
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 84.7 bits (208), Expect = 7e-17
Identities = 55/151 (36%), Positives = 85/151 (56%), Gaps = 5/151 (3%)
Query: 24 ITFDGKKRLDLSKMG---ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDL 80
I+F RL K+ I P I L++++ L L+RN I KIP + + LR+LDL
Sbjct: 633 ISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692
Query: 81 HSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTL 140
N + LP IG + +L L ++ NR+ + LP EL Q + +RA++LG N L S+P+ +
Sbjct: 693 SHNNLTFLPADIGLLQNLQNLAITANRIET--LPPELFQCRKLRALHLGNNVLQSLPSRV 750
Query: 141 GALKELHEVGLHDNLLNNIPVSISKLPKLKK 171
G L L ++ L N L +PV + + P LK+
Sbjct: 751 GELTNLTQIELRGNRLECLPVELGECPLLKR 781
Score = 65.5 bits (158), Expect = 5e-11
Identities = 42/149 (28%), Positives = 79/149 (53%), Gaps = 6/149 (4%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLR---WLDLHSNYIDKL 88
L+L + + P I L ++ E+DL N ++ I + IS FQ+L L L N+I +
Sbjct: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIIS-FQHLHRLTCLKLWYNHIAYI 654
Query: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
P IG +T+L L ++ N++ +P +L + +R ++L N+L +P +G L+ L
Sbjct: 655 PIQIGNLTNLERLYLNRNKIEK--IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ + N + +P + + KL+ L++ N
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNN 741
Score = 63.9 bits (154), Expect = 1e-10
Identities = 42/150 (28%), Positives = 78/150 (52%), Gaps = 4/150 (2%)
Query: 30 KRLDLSKMGITTFPKCIL--RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
+ +DL + T + I L + L L N I IP I NL L L+ N I+K
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 88 LPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
+P + L YL++S+N LT LP ++ L+N++ + + N ++++P L ++L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTF--LPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 148 EVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ L +N+L ++P + +L L ++ ++ N
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGN 764
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/132 (28%), Positives = 66/132 (50%), Gaps = 4/132 (3%)
Query: 48 RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIG--QMTSLLYLNVSN 105
+++++ EL+L R + +IP SI NL+ +DL N + + E I + L L +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 106 NRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISK 165
N + +P+++ L N+ + L N ++ +PT L ++L + L N L +P I
Sbjct: 649 NHIAY--IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 166 LPKLKKLNIKRN 177
L L+ L I N
Sbjct: 707 LQNLQNLAITAN 718
Score = 50.8 bits (120), Expect = 1e-06
Identities = 28/111 (25%), Positives = 56/111 (50%)
Query: 67 DSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAV 126
+S+ K NL L+L ++++P SI + +L +++ +N L + + + L + +
Sbjct: 585 NSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644
Query: 127 NLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L NH+ +P +G L L + L+ N + IP + KL+ L++ N
Sbjct: 645 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN 695
Score = 48.1 bits (113), Expect = 8e-06
Identities = 56/245 (22%), Positives = 96/245 (39%), Gaps = 36/245 (14%)
Query: 16 KVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRK-----IPDSIS 70
K+ + + + L + I P I L ++EL L+ NL + + D +
Sbjct: 482 KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLR 541
Query: 71 KFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGL 130
+ + L+ L L SN + KLP+ + + L NN T + LK++ N+ + L
Sbjct: 542 ELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
Query: 131 NHLDSVPTTLGALKELHEVGLHDNLLNNI-------------------------PVSISK 165
L+ +P ++ +L L E+ L DN L I P+ I
Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 166 LPKLKKLNIKRNPFPKPGESEIFIDSIRRLE---NLYVVEEKDLCAACLRKCQNARDNLN 222
L L++L + RN K + +R L+ N D+ L+ QN N
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI--GLLQNLQNLAITAN 718
Query: 223 RIKNM 227
RI+ +
Sbjct: 719 RIETL 723
Score = 43.1 bits (100), Expect = 2e-04
Identities = 37/128 (28%), Positives = 64/128 (50%), Gaps = 7/128 (5%)
Query: 53 DELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSL--LYLNVSNNRLTS 110
D+L+L ++ IPD++ L L L +P SI Q+T L L+L + ++ +
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 111 NGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLL--NNIPVSISKLPK 168
P +N+RA+++ + +P + +LK L E+ L NL NN + I L +
Sbjct: 486 ---PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRE 542
Query: 169 LKKLNIKR 176
LK+L + R
Sbjct: 543 LKRLKVLR 550
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 84.7 bits (208), Expect = 7e-17
Identities = 55/151 (36%), Positives = 85/151 (56%), Gaps = 5/151 (3%)
Query: 24 ITFDGKKRLDLSKMG---ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDL 80
I+F RL K+ I P I L++++ L L+RN I KIP + + LR+LDL
Sbjct: 633 ISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692
Query: 81 HSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTL 140
N + LP IG + +L L ++ NR+ + LP EL Q + +RA++LG N L S+P+ +
Sbjct: 693 SHNNLTFLPADIGLLQNLQNLAITANRIET--LPPELFQCRKLRALHLGNNVLQSLPSRV 750
Query: 141 GALKELHEVGLHDNLLNNIPVSISKLPKLKK 171
G L L ++ L N L +PV + + P LK+
Sbjct: 751 GELTNLTQIELRGNRLECLPVELGECPLLKR 781
Score = 65.5 bits (158), Expect = 5e-11
Identities = 42/149 (28%), Positives = 79/149 (53%), Gaps = 6/149 (4%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLR---WLDLHSNYIDKL 88
L+L + + P I L ++ E+DL N ++ I + IS FQ+L L L N+I +
Sbjct: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIIS-FQHLHRLTCLKLWYNHIAYI 654
Query: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
P IG +T+L L ++ N++ +P +L + +R ++L N+L +P +G L+ L
Sbjct: 655 PIQIGNLTNLERLYLNRNKIEK--IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ + N + +P + + KL+ L++ N
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNN 741
Score = 63.9 bits (154), Expect = 1e-10
Identities = 42/150 (28%), Positives = 78/150 (52%), Gaps = 4/150 (2%)
Query: 30 KRLDLSKMGITTFPKCIL--RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
+ +DL + T + I L + L L N I IP I NL L L+ N I+K
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 88 LPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
+P + L YL++S+N LT LP ++ L+N++ + + N ++++P L ++L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTF--LPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 148 EVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ L +N+L ++P + +L L ++ ++ N
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGN 764
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/132 (28%), Positives = 66/132 (50%), Gaps = 4/132 (3%)
Query: 48 RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIG--QMTSLLYLNVSN 105
+++++ EL+L R + +IP SI NL+ +DL N + + E I + L L +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 106 NRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISK 165
N + +P+++ L N+ + L N ++ +PT L ++L + L N L +P I
Sbjct: 649 NHIAY--IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 166 LPKLKKLNIKRN 177
L L+ L I N
Sbjct: 707 LQNLQNLAITAN 718
Score = 50.8 bits (120), Expect = 1e-06
Identities = 28/111 (25%), Positives = 56/111 (50%)
Query: 67 DSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAV 126
+S+ K NL L+L ++++P SI + +L +++ +N L + + + L + +
Sbjct: 585 NSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644
Query: 127 NLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L NH+ +P +G L L + L+ N + IP + KL+ L++ N
Sbjct: 645 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN 695
Score = 48.1 bits (113), Expect = 8e-06
Identities = 56/245 (22%), Positives = 96/245 (39%), Gaps = 36/245 (14%)
Query: 16 KVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRK-----IPDSIS 70
K+ + + + L + I P I L ++EL L+ NL + + D +
Sbjct: 482 KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLR 541
Query: 71 KFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGL 130
+ + L+ L L SN + KLP+ + + L NN T + LK++ N+ + L
Sbjct: 542 ELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
Query: 131 NHLDSVPTTLGALKELHEVGLHDNLLNNI-------------------------PVSISK 165
L+ +P ++ +L L E+ L DN L I P+ I
Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 166 LPKLKKLNIKRNPFPKPGESEIFIDSIRRLE---NLYVVEEKDLCAACLRKCQNARDNLN 222
L L++L + RN K + +R L+ N D+ L+ QN N
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI--GLLQNLQNLAITAN 718
Query: 223 RIKNM 227
RI+ +
Sbjct: 719 RIETL 723
Score = 43.1 bits (100), Expect = 2e-04
Identities = 37/128 (28%), Positives = 64/128 (50%), Gaps = 7/128 (5%)
Query: 53 DELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSL--LYLNVSNNRLTS 110
D+L+L ++ IPD++ L L L +P SI Q+T L L+L + ++ +
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 111 NGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLL--NNIPVSISKLPK 168
P +N+RA+++ + +P + +LK L E+ L NL NN + I L +
Sbjct: 486 ---PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRE 542
Query: 169 LKKLNIKR 176
LK+L + R
Sbjct: 543 LKRLKVLR 550
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 84.7 bits (208), Expect = 7e-17
Identities = 55/151 (36%), Positives = 85/151 (56%), Gaps = 5/151 (3%)
Query: 24 ITFDGKKRLDLSKMG---ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDL 80
I+F RL K+ I P I L++++ L L+RN I KIP + + LR+LDL
Sbjct: 633 ISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDL 692
Query: 81 HSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTL 140
N + LP IG + +L L ++ NR+ + LP EL Q + +RA++LG N L S+P+ +
Sbjct: 693 SHNNLTFLPADIGLLQNLQNLAITANRIET--LPPELFQCRKLRALHLGNNVLQSLPSRV 750
Query: 141 GALKELHEVGLHDNLLNNIPVSISKLPKLKK 171
G L L ++ L N L +PV + + P LK+
Sbjct: 751 GELTNLTQIELRGNRLECLPVELGECPLLKR 781
Score = 65.5 bits (158), Expect = 5e-11
Identities = 42/149 (28%), Positives = 79/149 (53%), Gaps = 6/149 (4%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLR---WLDLHSNYIDKL 88
L+L + + P I L ++ E+DL N ++ I + IS FQ+L L L N+I +
Sbjct: 596 LELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIIS-FQHLHRLTCLKLWYNHIAYI 654
Query: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
P IG +T+L L ++ N++ +P +L + +R ++L N+L +P +G L+ L
Sbjct: 655 PIQIGNLTNLERLYLNRNKIEK--IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQN 712
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ + N + +P + + KL+ L++ N
Sbjct: 713 LAITANRIETLPPELFQCRKLRALHLGNN 741
Score = 63.9 bits (154), Expect = 1e-10
Identities = 42/150 (28%), Positives = 78/150 (52%), Gaps = 4/150 (2%)
Query: 30 KRLDLSKMGITTFPKCIL--RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
+ +DL + T + I L + L L N I IP I NL L L+ N I+K
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Query: 88 LPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
+P + L YL++S+N LT LP ++ L+N++ + + N ++++P L ++L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTF--LPADIGLLQNLQNLAITANRIETLPPELFQCRKLR 734
Query: 148 EVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ L +N+L ++P + +L L ++ ++ N
Sbjct: 735 ALHLGNNVLQSLPSRVGELTNLTQIELRGN 764
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/132 (28%), Positives = 66/132 (50%), Gaps = 4/132 (3%)
Query: 48 RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIG--QMTSLLYLNVSN 105
+++++ EL+L R + +IP SI NL+ +DL N + + E I + L L +
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 106 NRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISK 165
N + +P+++ L N+ + L N ++ +PT L ++L + L N L +P I
Sbjct: 649 NHIAY--IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 166 LPKLKKLNIKRN 177
L L+ L I N
Sbjct: 707 LQNLQNLAITAN 718
Score = 50.8 bits (120), Expect = 1e-06
Identities = 28/111 (25%), Positives = 56/111 (50%)
Query: 67 DSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAV 126
+S+ K NL L+L ++++P SI + +L +++ +N L + + + L + +
Sbjct: 585 NSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCL 644
Query: 127 NLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L NH+ +P +G L L + L+ N + IP + KL+ L++ N
Sbjct: 645 KLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHN 695
Score = 48.1 bits (113), Expect = 8e-06
Identities = 56/245 (22%), Positives = 96/245 (39%), Gaps = 36/245 (14%)
Query: 16 KVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRK-----IPDSIS 70
K+ + + + L + I P I L ++EL L+ NL + + D +
Sbjct: 482 KIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLR 541
Query: 71 KFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGL 130
+ + L+ L L SN + KLP+ + + L NN T + LK++ N+ + L
Sbjct: 542 ELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR 600
Query: 131 NHLDSVPTTLGALKELHEVGLHDNLLNNI-------------------------PVSISK 165
L+ +P ++ +L L E+ L DN L I P+ I
Sbjct: 601 CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN 660
Query: 166 LPKLKKLNIKRNPFPKPGESEIFIDSIRRLE---NLYVVEEKDLCAACLRKCQNARDNLN 222
L L++L + RN K + +R L+ N D+ L+ QN N
Sbjct: 661 LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADI--GLLQNLQNLAITAN 718
Query: 223 RIKNM 227
RI+ +
Sbjct: 719 RIETL 723
Score = 43.1 bits (100), Expect = 2e-04
Identities = 37/128 (28%), Positives = 64/128 (50%), Gaps = 7/128 (5%)
Query: 53 DELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSL--LYLNVSNNRLTS 110
D+L+L ++ IPD++ L L L +P SI Q+T L L+L + ++ +
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 111 NGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLL--NNIPVSISKLPK 168
P +N+RA+++ + +P + +LK L E+ L NL NN + I L +
Sbjct: 486 ---PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRE 542
Query: 169 LKKLNIKR 176
LK+L + R
Sbjct: 543 LKRLKVLR 550
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 83.6 bits (205), Expect = 2e-16
Identities = 53/146 (36%), Positives = 81/146 (55%), Gaps = 3/146 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L LS + FP L+D + DLSRN +IP + F L L+L+ N I +PE+
Sbjct: 93 LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
I + L YLN+S N L++ LP L L ++ + + N L S+P +G LK+L E+ +
Sbjct: 153 IKNLQMLTYLNISRNLLST--LPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDI 209
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177
N + +P + KL L++LNI+RN
Sbjct: 210 SCNEIQVLPQQMGKLHSLRELNIRRN 235
Score = 55.5 bits (132), Expect = 5e-08
Identities = 41/138 (29%), Positives = 75/138 (54%), Gaps = 8/138 (5%)
Query: 15 LKVARNCI----KITFD-GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSI 69
L ++RN + K FD K L +S + + P+ I +L D+ ELD+S N I+ +P +
Sbjct: 162 LNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQM 221
Query: 70 SKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLG 129
K +LR L++ N + LP+ +G + L+ L+ S N++T +PV ++L +++ + L
Sbjct: 222 GKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTE--IPVCYRKLHHLQVIILD 278
Query: 130 LNHLDSVPTTLGALKELH 147
N L P + ++H
Sbjct: 279 NNPLQVPPAQICLKGKVH 296
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 83.6 bits (205), Expect = 2e-16
Identities = 44/146 (30%), Positives = 82/146 (56%), Gaps = 2/146 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LD+ +T+ P I L ++ +L++S N ++ +P+ I+ +NL+ L L N + + E
Sbjct: 110 LDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEG 169
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
Q+++L L++SNN LT+ +P L ++ +NL N L S+P + +K L +
Sbjct: 170 FEQLSNLEDLDLSNNHLTT--VPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDC 227
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177
+ NLL IP ++ + L+ L ++RN
Sbjct: 228 NSNLLETIPPELAGMESLELLYLRRN 253
Score = 77.4 bits (189), Expect = 1e-14
Identities = 53/192 (27%), Positives = 93/192 (48%), Gaps = 30/192 (15%)
Query: 31 RLDLSKMGITTFPKCILRLS-----------------------DMDELDLSRNLIRKIPD 67
+L+LS ++ P+C+ R++ D+ +L +S N ++ + D
Sbjct: 40 QLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTD 99
Query: 68 SISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVN 127
+ L LD+H N + LP +I ++ +L LNVS+N+L LP E+ L+N++ +
Sbjct: 100 DLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI--LPEEITNLRNLKCLY 157
Query: 128 LGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPK-PGESE 186
L N L + L L ++ L +N L +P S S L L +LN+ N P E
Sbjct: 158 LQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAE-- 215
Query: 187 IFIDSIRRLENL 198
I+ ++RL++L
Sbjct: 216 --INRMKRLKHL 225
Score = 68.9 bits (167), Expect = 4e-12
Identities = 50/168 (29%), Positives = 83/168 (49%), Gaps = 22/168 (13%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LDLS +TT P LS + L+LS N ++ +P I++ + L+ LD +SN ++ +P
Sbjct: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPE 238
Query: 92 IGQMTSLLYLNVSNNRLT-----------------SNGLPV----ELKQLKNIRAVNLGL 130
+ M SL L + N+L N + + LK L +I ++L
Sbjct: 239 LAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRD 298
Query: 131 NHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNP 178
N L SVP + L+ L + L +N ++++P S+ L LK L ++ NP
Sbjct: 299 NKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNP 345
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/153 (28%), Positives = 77/153 (50%), Gaps = 4/153 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDM-DELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPE 90
++ SK + PK ++ L +M ++DLS N + I + Q L +LDL +N+++ LPE
Sbjct: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPE 489
Query: 91 SIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSV-PTTLGALKELHEV 149
+ + L +N+S NR LP L ++ + + + N + SV P + ++ L +
Sbjct: 490 EMESLVRLQTINLSFNRFKM--LPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTL 547
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKP 182
L +N L IP + L+ L + NPF P
Sbjct: 548 DLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVP 580
Score = 62.8 bits (151), Expect = 3e-10
Identities = 54/192 (28%), Positives = 89/192 (46%), Gaps = 31/192 (16%)
Query: 15 LKVARNCIKI------TFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDS 68
L V+ N +KI K L L +T + +LS++++LDLS N + +P S
Sbjct: 133 LNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPAS 192
Query: 69 ISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNL 128
S +L L+L SN + LP I +M L +L+ ++N L + +P EL ++++ + L
Sbjct: 193 FSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLET--IPPELAGMESLELLYL 250
Query: 129 GLNHLDSVP--TTLGALKELH---------------------EVGLHDNLLNNIPVSISK 165
N L +P + LKELH + L DN L ++P I
Sbjct: 251 RRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL 310
Query: 166 LPKLKKLNIKRN 177
L L++L++ N
Sbjct: 311 LRSLERLDLSNN 322
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 83.2 bits (204), Expect = 2e-16
Identities = 49/148 (33%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Query: 31 RLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPE 90
+L++ +T+ P + M EL+L+ N + KIP+ +S +L L L +N + KLP
Sbjct: 383 KLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPH 442
Query: 91 SIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVG 150
+G + L L++ N+L S LP E+ LK+++ + L N L ++P +G L L +G
Sbjct: 443 GLGNLRKLRELDLEENKLES--LPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG 500
Query: 151 LHDNLLNNIPVSISKLPKLKKLNIKRNP 178
L +NLL ++P I L L++L + NP
Sbjct: 501 LGENLLTHLPEEIGTLENLEELYLNDNP 528
Score = 82.4 bits (202), Expect = 4e-16
Identities = 50/155 (32%), Positives = 86/155 (55%), Gaps = 3/155 (1%)
Query: 25 TFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNY 84
T+ L+L+ +T P+ + L ++ L LS NL++K+P + + LR LDL N
Sbjct: 400 TWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENK 459
Query: 85 IDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALK 144
++ LP I + L L ++NN+LT+ LP + L N+ + LG N L +P +G L+
Sbjct: 460 LESLPNEIAYLKDLQKLVLTNNQLTT--LPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517
Query: 145 ELHEVGLHDN-LLNNIPVSISKLPKLKKLNIKRNP 178
L E+ L+DN L+++P ++ KL ++I+ P
Sbjct: 518 NLEELYLNDNPNLHSLPFELALCSKLSIMSIENCP 552
Score = 75.9 bits (185), Expect = 3e-14
Identities = 64/263 (24%), Positives = 115/263 (43%), Gaps = 29/263 (11%)
Query: 7 GPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDE------------ 54
G + K +V + K + RLDLSK I P I L+ + E
Sbjct: 80 GTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLP 139
Query: 55 -----------LDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNV 103
L LS N + +PDS+ + LR LDL N + ++P + ++ SL L +
Sbjct: 140 AEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYL 199
Query: 104 SNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSI 163
NR+T+ + ++K L + +++ N + +P +G L L + + N L ++P I
Sbjct: 200 RFNRITT--VEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEI 257
Query: 164 SKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAACLRKCQNARDNLNR 223
++ L+++ N ++ + S+ RL Y L KC +A + LN
Sbjct: 258 GNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRY--NRLSAIPRSLAKC-SALEELNL 314
Query: 224 IKNMATTTPRKTIFPNLISPNSM 246
N +T P +++ +L+ NS+
Sbjct: 315 ENNNISTLP-ESLLSSLVKLNSL 336
Score = 67.8 bits (164), Expect = 9e-12
Identities = 47/169 (27%), Positives = 87/169 (51%), Gaps = 5/169 (2%)
Query: 30 KRLDLSKMGITTFPKCILR-LSDMDELDLSRNLIRKIP-DSISKFQNLRWLDLHSNYIDK 87
+ L+L I+T P+ +L L ++ L L+RN + P S+F + L++ N I+K
Sbjct: 310 EELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINK 369
Query: 88 LPESIGQMTSLLY-LNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKEL 146
+P I +L LN+ +N+LTS LP++ ++ +NL N L +P + L L
Sbjct: 370 IPFGIFSRAKVLSKLNMKDNQLTS--LPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSL 427
Query: 147 HEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRL 195
+ L +NLL +P + L KL++L+++ N ++ +++L
Sbjct: 428 EVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKL 476
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 82.8 bits (203), Expect = 3e-16
Identities = 60/204 (29%), Positives = 104/204 (50%), Gaps = 15/204 (7%)
Query: 27 DGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYID 86
DG+ L + K T P +L+L+ + E L R + KIP+ I +FQNL LDL N I
Sbjct: 60 DGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTIS 119
Query: 87 KLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNH-LDSVPTTLGALKE 145
++P IG +T L L +S N++ + +P EL ++ + L +N + +P L L +
Sbjct: 120 EIPPGIGLLTRLQELILSYNKIKT--VPKELSNCASLEKLELAVNRDICDLPQELSNLLK 177
Query: 146 LHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKD 205
L + L N IP+++ +P L+ L++ N + E D+I R++NL+ + +
Sbjct: 178 LTHLDLSMNDFTTIPLAVLNMPALEWLDMGSN------KLEQLPDTIERMQNLHTLWLQR 231
Query: 206 LCAACLRKCQNARDNLNRIKNMAT 229
CL + ++ +KN+ T
Sbjct: 232 NEITCLPQ------TISNMKNLGT 249
Score = 70.1 bits (170), Expect = 2e-12
Identities = 46/129 (35%), Positives = 72/129 (55%), Gaps = 10/129 (7%)
Query: 20 NCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLD 79
N +K+T LDLS TT P +L + ++ LD+ N + ++PD+I + QNL L
Sbjct: 174 NLLKLT-----HLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLW 228
Query: 80 LHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLD---SV 136
L N I LP++I M +L L +SNN+L +PV ++++ N+R VN N L S+
Sbjct: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKL--QDIPVCMEEMANLRFVNFRDNPLKLKVSL 286
Query: 137 PTTLGALKE 145
P + G +E
Sbjct: 287 PPSEGTDEE 295
Score = 68.9 bits (167), Expect = 4e-12
Identities = 49/173 (28%), Positives = 90/173 (52%), Gaps = 9/173 (5%)
Query: 13 ITLKVARNCIKITFDG------KKRLDLSKMGITTFPKCILRLSDMDELDLSRNL-IRKI 65
I L ++RN I G + L LS I T PK + + +++L+L+ N I +
Sbjct: 109 IVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDL 168
Query: 66 PDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRA 125
P +S L LDL N +P ++ M +L +L++ +N+L LP +++++N+
Sbjct: 169 PQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ--LPDTIERMQNLHT 226
Query: 126 VNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNP 178
+ L N + +P T+ +K L + L +N L +IPV + ++ L+ +N + NP
Sbjct: 227 LWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNP 279
Score = 62.4 bits (150), Expect = 4e-10
Identities = 43/146 (29%), Positives = 70/146 (47%), Gaps = 8/146 (5%)
Query: 12 KITLKVARNCIKITFDGKKRLDLS-KMGITTFPKCILRLSDMDELDLSRNLIRKIPDSIS 70
K K NC + ++L+L+ I P+ + L + LDLS N IP ++
Sbjct: 142 KTVPKELSNCASL-----EKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVL 196
Query: 71 KFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGL 130
L WLD+ SN +++LP++I +M +L L + N +T LP + +KN+ + L
Sbjct: 197 NMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITC--LPQTISNMKNLGTLVLSN 254
Query: 131 NHLDSVPTTLGALKELHEVGLHDNLL 156
N L +P + + L V DN L
Sbjct: 255 NKLQDIPVCMEEMANLRFVNFRDNPL 280
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 82.0 bits (201), Expect = 5e-16
Identities = 47/164 (28%), Positives = 92/164 (56%), Gaps = 2/164 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L+L + + T PK + +L+ ++ LDL N ++P+ + + QNLR L + +N + LP S
Sbjct: 166 LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGS 225
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
IG++ L+YL++S NR+ + + +++ + + + L N L +P ++G LK+L + +
Sbjct: 226 IGKLKMLVYLDMSKNRIET--VDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRL 195
DN L +P +I L L++ + N + ++ S+R L
Sbjct: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTL 327
Score = 81.6 bits (200), Expect = 6e-16
Identities = 58/220 (26%), Positives = 108/220 (49%), Gaps = 11/220 (5%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
K LD+SK G+ FP+ I + ++ S N I K+PD ++ NL L L+ +++ LP
Sbjct: 95 KELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLP 154
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ G++ L L + N L + LP + +L + ++LG N +P L ++ L E+
Sbjct: 155 ANFGRLVKLRILELRENHLKT--LPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAA 209
+ +N L +P SI KL L L++ +N + ++ I LE+L L +
Sbjct: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKN---RIETVDMDISGCEALEDLL------LSSN 263
Query: 210 CLRKCQNARDNLNRIKNMATTTPRKTIFPNLISPNSMAKD 249
L++ ++ L ++ + + T+ PN I S+ ++
Sbjct: 264 MLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEE 303
Score = 74.3 bits (181), Expect = 1e-13
Identities = 50/167 (29%), Positives = 81/167 (48%), Gaps = 21/167 (12%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
LD+SK I T I +++L LS N+++++PDSI + L L + N + LP +
Sbjct: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNT 294
Query: 92 IGQMTSLLYLNVSNNRLTS---------------------NGLPVELKQLKNIRAVNLGL 130
IG ++ L + S N L S LP E+ KN+ ++L
Sbjct: 295 IGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRS 354
Query: 131 NHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
N L+ +P +G +++L + L DN L N+P S +KL +L L + N
Sbjct: 355 NKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
Score = 69.7 bits (169), Expect = 2e-12
Identities = 48/171 (28%), Positives = 83/171 (48%), Gaps = 5/171 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ L L I PK + + +L + N + +P +I+ NL+ LD+ N + + P
Sbjct: 49 EELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFP 108
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
E+I L + S N ++ LP QL N+ + L L+ +P G L +L +
Sbjct: 109 ENIKCCKCLTIIEASVNPISK--LPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRIL 166
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYV 200
L +N L +P S+ KL +L++L++ N F GE +D I+ L L++
Sbjct: 167 ELRENHLKTLPKSMHKLAQLERLDLGNNEF---GELPEVLDQIQNLRELWM 214
Score = 54.7 bits (130), Expect = 8e-08
Identities = 34/102 (33%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ D S + + P I L + L + N + ++P I +N+ + L SN ++ LP
Sbjct: 302 EEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP 361
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLN 131
E IGQM L LN+S+NRL LP +LK + A+ L N
Sbjct: 362 EEIGQMQKLRVLNLSDNRL--KNLPFSFTKLKELAALWLSDN 401
Score = 33.5 bits (75), Expect = 0.19
Identities = 19/65 (29%), Positives = 34/65 (52%)
Query: 43 PKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLN 102
P+ I ++ + L N + +P+ I + Q LR L+L N + LP S ++ L L
Sbjct: 338 PREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALW 397
Query: 103 VSNNR 107
+S+N+
Sbjct: 398 LSDNQ 402
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 81.6 bits (200), Expect = 6e-16
Identities = 58/189 (30%), Positives = 96/189 (50%), Gaps = 15/189 (7%)
Query: 11 KKIT-LKVARNCIKITFDGKKRLD------LSKMGITTFPKCILRLSDMDELDLSRNLIR 63
K++T L V++N I++ +G + LS + P+ I L ++ L + N +
Sbjct: 230 KQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLM 289
Query: 64 KIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNI 123
+PDSI ++ LD N ++ LP SIGQ+T+L +N L LP E+ KNI
Sbjct: 290 YLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ--LPPEIGSWKNI 347
Query: 124 RAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN------ 177
+ L N L+++P +G +++L + L DN L N+P S +KL +L + + N
Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407
Query: 178 PFPKPGESE 186
P K +SE
Sbjct: 408 PLQKETDSE 416
Score = 80.1 bits (196), Expect = 2e-15
Identities = 60/200 (30%), Positives = 95/200 (47%), Gaps = 14/200 (7%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ LD+SK GI FP+ I + ++ S N I K+PD S+ NL L L+ +++ LP
Sbjct: 95 RELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ G++T L L + N+L LP + +L + ++LG N VP L L L E
Sbjct: 155 ANFGRLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAA 209
+ N L IP I L +L L++ +N E+ + I ENL +DL +
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKN------NIEMVEEGISTCENL-----QDLLLS 261
Query: 210 CLRKCQNARDNLNRIKNMAT 229
Q + + +KN+ T
Sbjct: 262 S-NSLQQLPETIGSLKNITT 280
Score = 73.9 bits (180), Expect = 1e-13
Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 21/171 (12%)
Query: 28 GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
G K + +T P I L + LD+S+N I + + IS +NL+ L L SN + +
Sbjct: 208 GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
Query: 88 LPESIGQMTSLLYLNVSNNRL---------------------TSNGLPVELKQLKNIRAV 126
LPE+IG + ++ L + N+L LP + QL N+R
Sbjct: 268 LPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
Query: 127 NLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
N+L +P +G+ K + + LH N L +P + + KLK +N+ N
Sbjct: 328 AADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
Score = 66.6 bits (161), Expect = 2e-11
Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 2/155 (1%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ L L I PK + + +L L N + +P SI+ NLR LD+ N I + P
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFP 108
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
E+I L + S N ++ LP QL N+ + L L+ +P G L +L +
Sbjct: 109 ENIKNCKVLTIVEASVNPISK--LPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQIL 166
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGE 184
L +N L +P ++++L +L++L++ N F + E
Sbjct: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
Score = 41.6 bits (96), Expect = 7e-04
Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 121 KNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP 180
K + + L N ++ +P L + LH++ L DN L +P SI+ L L++L++ +N
Sbjct: 46 KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ 105
Query: 181 KPGESEIFIDSIRRLENLYVVE 202
+ F ++I+ + L +VE
Sbjct: 106 E------FPENIKNCKVLTIVE 121
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 81.6 bits (200), Expect = 6e-16
Identities = 58/189 (30%), Positives = 96/189 (50%), Gaps = 15/189 (7%)
Query: 11 KKIT-LKVARNCIKITFDGKKRLD------LSKMGITTFPKCILRLSDMDELDLSRNLIR 63
K++T L V++N I++ +G + LS + P+ I L ++ L + N +
Sbjct: 230 KQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLM 289
Query: 64 KIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNI 123
+PDSI ++ LD N ++ LP SIGQ+T+L +N L LP E+ KNI
Sbjct: 290 YLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ--LPPEIGSWKNI 347
Query: 124 RAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN------ 177
+ L N L+++P +G +++L + L DN L N+P S +KL +L + + N
Sbjct: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407
Query: 178 PFPKPGESE 186
P K +SE
Sbjct: 408 PLQKETDSE 416
Score = 80.1 bits (196), Expect = 2e-15
Identities = 60/200 (30%), Positives = 95/200 (47%), Gaps = 14/200 (7%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ LD+SK GI FP+ I + ++ S N I K+PD S+ NL L L+ +++ LP
Sbjct: 95 RELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ G++T L L + N+L LP + +L + ++LG N VP L L L E
Sbjct: 155 ANFGRLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAA 209
+ N L IP I L +L L++ +N E+ + I ENL +DL +
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKN------NIEMVEEGISTCENL-----QDLLLS 261
Query: 210 CLRKCQNARDNLNRIKNMAT 229
Q + + +KN+ T
Sbjct: 262 S-NSLQQLPETIGSLKNITT 280
Score = 73.9 bits (180), Expect = 1e-13
Identities = 48/171 (28%), Positives = 78/171 (45%), Gaps = 21/171 (12%)
Query: 28 GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
G K + +T P I L + LD+S+N I + + IS +NL+ L L SN + +
Sbjct: 208 GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
Query: 88 LPESIGQMTSLLYLNVSNNRL---------------------TSNGLPVELKQLKNIRAV 126
LPE+IG + ++ L + N+L LP + QL N+R
Sbjct: 268 LPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
Query: 127 NLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
N+L +P +G+ K + + LH N L +P + + KLK +N+ N
Sbjct: 328 AADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
Score = 66.6 bits (161), Expect = 2e-11
Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 2/155 (1%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ L L I PK + + +L L N + +P SI+ NLR LD+ N I + P
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFP 108
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
E+I L + S N ++ LP QL N+ + L L+ +P G L +L +
Sbjct: 109 ENIKNCKVLTIVEASVNPISK--LPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQIL 166
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGE 184
L +N L +P ++++L +L++L++ N F + E
Sbjct: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
Score = 41.6 bits (96), Expect = 7e-04
Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 121 KNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFP 180
K + + L N ++ +P L + LH++ L DN L +P SI+ L L++L++ +N
Sbjct: 46 KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ 105
Query: 181 KPGESEIFIDSIRRLENLYVVE 202
+ F ++I+ + L +VE
Sbjct: 106 E------FPENIKNCKVLTIVE 121
>gi|194394161 leucine rich repeat containing 57 [Homo sapiens]
Length = 239
Score = 81.6 bits (200), Expect = 6e-16
Identities = 46/149 (30%), Positives = 89/149 (59%), Gaps = 4/149 (2%)
Query: 30 KRLDLSKMGITTFPKCIL-RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKL 88
+ +DLS I + P ++ + + + L L+ N + +PD I + L L L++N++ +L
Sbjct: 41 RTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLREL 100
Query: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
P + GQ+++L L++S N+L LP +L L+++ ++L N + S+P ++G L+ + E
Sbjct: 101 PSTFGQLSALKTLSLSGNQL--GALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVI-E 157
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ L+ N ++ I V IS P+LK L ++ N
Sbjct: 158 LNLNQNQISQISVKISCCPRLKILRLEEN 186
Score = 66.2 bits (160), Expect = 3e-11
Identities = 41/118 (34%), Positives = 65/118 (55%), Gaps = 4/118 (3%)
Query: 62 IRKIPDSISKF-QNLRWLDLHSNYIDKLPE-SIGQMTSLLYLNVSNNRLTSNGLPVELKQ 119
+ + P + K NLR +DL +N I+ LP IG+ T L L+++NN+LT LP E+
Sbjct: 26 LTEFPADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTV--LPDEICN 83
Query: 120 LKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
LK + ++L NHL +P+T G L L + L N L +P + L L +++ +N
Sbjct: 84 LKKLETLSLNNNHLRELPSTFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKN 141
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 80.9 bits (198), Expect = 1e-15
Identities = 45/135 (33%), Positives = 75/135 (55%)
Query: 43 PKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLN 102
P I L +++ L+ N I ++P IS Q L+ L+L N ++ LP G + +L L+
Sbjct: 3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 62
Query: 103 VSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVS 162
++ N L+ N LP L +RA+ L N + +P +G L +L + L DN L ++P
Sbjct: 63 LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE 122
Query: 163 ISKLPKLKKLNIKRN 177
I +L +LK+L+I+ N
Sbjct: 123 IGELTQLKELHIQGN 137
Score = 45.4 bits (106), Expect = 5e-05
Identities = 34/143 (23%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 113 LPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKL 172
+P + +LKN+ +N N ++ +PT + +L++L + L N LN +P LP L+ L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 173 NIKRNPFPK---PGESEIFIDSIRRL---ENLYVVEEKDLCAACLRKCQNARDN------ 220
++ N + PG + ++ ++R L +N + + D+ + + RDN
Sbjct: 62 DLTYNNLSENSLPG-NFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
Query: 221 -----LNRIKNMATTTPRKTIFP 238
L ++K + R T+ P
Sbjct: 121 KEIGELTQLKELHIQGNRLTVLP 143
Score = 44.7 bits (104), Expect = 8e-05
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 2/89 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L + + + P L+ + L LS N +P I K L+ L L N + LP+
Sbjct: 63 LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE 122
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQL 120
IG++T L L++ NRLT LP EL L
Sbjct: 123 IGELTQLKELHIQGNRLTV--LPPELGNL 149
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 80.1 bits (196), Expect = 2e-15
Identities = 54/171 (31%), Positives = 89/171 (52%), Gaps = 5/171 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
++L+LS + P + L+ ++ELD+S N + +PDS+S LR LD+ N + P
Sbjct: 138 RKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP 197
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ Q+ +L L+VS+NRL GLP ++ L+ ++ + L L ++P L L +
Sbjct: 198 RQLLQLVALEELDVSSNRL--RGLPEDISALRALKILWLSGAELGTLPAGFCELASLESL 255
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYV 200
L +N L +P S L +LK LN+ N F E + + LE LY+
Sbjct: 256 MLDNNGLQALPAQFSCLQRLKMLNLSSNLFE---EFPAALLPLAGLEELYL 303
Score = 75.9 bits (185), Expect = 3e-14
Identities = 58/177 (32%), Positives = 96/177 (54%), Gaps = 20/177 (11%)
Query: 43 PKCIL--RLSDMDELDLSRNLIRKIPDSI-SKFQNLRWLDLHSNYIDKLPESIGQMTS-L 98
P+ +L L D++ L+L N + ++P+ + S +LR L L N +LP ++ ++ L
Sbjct: 54 PQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 99 LYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNN 158
L+VS+NRLT+ G V + L+ +R +NL N L ++P LGAL L E+ + N L +
Sbjct: 114 TELDVSHNRLTALGAEV-VSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH 172
Query: 159 IPVSISKLPKLKKLNIKRN---PFPKPGESEIFIDSIRRLENLYVVEEKDLCAACLR 212
+P S+S L +L+ L++ N FP R+L L +EE D+ + LR
Sbjct: 173 LPDSLSCLSRLRTLDVDHNQLTAFP------------RQLLQLVALEELDVSSNRLR 217
Score = 74.3 bits (181), Expect = 1e-13
Identities = 48/148 (32%), Positives = 78/148 (52%), Gaps = 2/148 (1%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+ LD+ +T FP+ +L+L ++ELD+S N +R +P+ IS + L+ L L + LP
Sbjct: 184 RTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLP 243
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
++ SL L + NN L + LP + L+ ++ +NL N + P L L L E+
Sbjct: 244 AGFCELASLESLMLDNNGLQA--LPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEEL 301
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L N L ++P IS L +L L + N
Sbjct: 302 YLSRNQLTSVPSLISGLGRLLTLWLDNN 329
Score = 49.7 bits (117), Expect = 3e-06
Identities = 34/94 (36%), Positives = 49/94 (52%), Gaps = 2/94 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
K L+LS FP +L L+ ++EL LSRN + +P IS L L L +N I LP
Sbjct: 276 KMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLP 335
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNI 123
+SI ++T L L + N++ LP QL +
Sbjct: 336 DSIVELTGLEELVLQGNQIAV--LPDHFGQLSRV 367
Score = 47.8 bits (112), Expect = 1e-05
Identities = 39/119 (32%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 28 GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
G + L LS+ +T+ P I L + L L N IR +PDSI + L L L N I
Sbjct: 297 GLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAV 356
Query: 88 LPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKEL 146
LP+ GQ++ + + +N L V +K + I A L H S P LK L
Sbjct: 357 LPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAH--SQPAVQPRLKLL 413
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 79.3 bits (194), Expect = 3e-15
Identities = 56/180 (31%), Positives = 91/180 (50%), Gaps = 8/180 (4%)
Query: 4 GEKGPKGKKITLKVARNCIK-----ITFDGK-KRLDLSKMGITTFPKCILRLSDMDELDL 57
G+ G +TL++ N +K ++F K ++LDL + P + L ++ EL L
Sbjct: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
Query: 58 SRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVEL 117
RN + +P + + L LD+ N +++LP +G + L L +S N L LP +
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL--RRLPDGI 262
Query: 118 KQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
QLK + + + N L V +G + L E+ L +NLL +P S+ KL KL LN+ RN
Sbjct: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322
Score = 76.6 bits (187), Expect = 2e-14
Identities = 45/146 (30%), Positives = 82/146 (56%), Gaps = 2/146 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L L+ + + P + L+++ L+L NL++ +P S+S L LDL N ++ LP++
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
+G + +L L + N+L++ LP EL L+ + +++ N L+ +P LG L L ++ L
Sbjct: 193 LGALPNLRELWLDRNQLSA--LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLL 250
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177
NLL +P I +L +L L + +N
Sbjct: 251 SQNLLRRLPDGIGQLKQLSILKVDQN 276
Score = 75.1 bits (183), Expect = 6e-14
Identities = 56/176 (31%), Positives = 91/176 (51%), Gaps = 7/176 (3%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
++L LS I P + + ELD+SRN I +IP+SI + L D N + +LP
Sbjct: 62 RKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ Q+ SL +L + N ++ LP ++ L N+ + L N L S+P +L L +L ++
Sbjct: 122 DGFTQLRSLAHLAL--NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPK-PGESEIFIDSIRRLENLYVVEEK 204
L N L +P ++ LP L++L + RN P E + ++RRL L V E +
Sbjct: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE----LGNLRRLVCLDVSENR 231
Score = 72.8 bits (177), Expect = 3e-13
Identities = 51/156 (32%), Positives = 85/156 (54%), Gaps = 8/156 (5%)
Query: 43 PKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLN 102
PK RL ++ +L LS N I+++P ++ F L LD+ N I ++PESI +L +
Sbjct: 52 PKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIAD 111
Query: 103 VSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVS 162
S N L+ LP QL+++ + L L ++P +G L L + L +NLL ++P S
Sbjct: 112 FSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS 169
Query: 163 ISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENL 198
+S L KL++L++ N + E+ D++ L NL
Sbjct: 170 LSFLVKLEQLDLGGN------DLEVLPDTLGALPNL 199
Score = 59.3 bits (142), Expect = 3e-09
Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 3/144 (2%)
Query: 34 LSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIG 93
LS+ + P I +L + L + +N + ++ ++I +NL L L N + LP S+G
Sbjct: 250 LSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLG 309
Query: 94 QMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHD 153
++T L LNV N L LP E+ + ++L N L +P L ELH + +
Sbjct: 310 KLTKLTNLNVDRNHL--EALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAG 367
Query: 154 NLLNNIPVSISKLPKLKKLNIKRN 177
N L ++P +++ L LK L + N
Sbjct: 368 NRLQSLPFALTHL-NLKALWLAEN 390
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 79.3 bits (194), Expect = 3e-15
Identities = 56/180 (31%), Positives = 91/180 (50%), Gaps = 8/180 (4%)
Query: 4 GEKGPKGKKITLKVARNCIK-----ITFDGK-KRLDLSKMGITTFPKCILRLSDMDELDL 57
G+ G +TL++ N +K ++F K ++LDL + P + L ++ EL L
Sbjct: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
Query: 58 SRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVEL 117
RN + +P + + L LD+ N +++LP +G + L L +S N L LP +
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL--RRLPDGI 262
Query: 118 KQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
QLK + + + N L V +G + L E+ L +NLL +P S+ KL KL LN+ RN
Sbjct: 263 GQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRN 322
Score = 76.6 bits (187), Expect = 2e-14
Identities = 45/146 (30%), Positives = 82/146 (56%), Gaps = 2/146 (1%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L L+ + + P + L+++ L+L NL++ +P S+S L LDL N ++ LP++
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
+G + +L L + N+L++ LP EL L+ + +++ N L+ +P LG L L ++ L
Sbjct: 193 LGALPNLRELWLDRNQLSA--LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLL 250
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRN 177
NLL +P I +L +L L + +N
Sbjct: 251 SQNLLRRLPDGIGQLKQLSILKVDQN 276
Score = 75.1 bits (183), Expect = 6e-14
Identities = 56/176 (31%), Positives = 91/176 (51%), Gaps = 7/176 (3%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
++L LS I P + + ELD+SRN I +IP+SI + L D N + +LP
Sbjct: 62 RKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLP 121
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ Q+ SL +L + N ++ LP ++ L N+ + L N L S+P +L L +L ++
Sbjct: 122 DGFTQLRSLAHLAL--NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPK-PGESEIFIDSIRRLENLYVVEEK 204
L N L +P ++ LP L++L + RN P E + ++RRL L V E +
Sbjct: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE----LGNLRRLVCLDVSENR 231
Score = 72.8 bits (177), Expect = 3e-13
Identities = 51/156 (32%), Positives = 85/156 (54%), Gaps = 8/156 (5%)
Query: 43 PKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLN 102
PK RL ++ +L LS N I+++P ++ F L LD+ N I ++PESI +L +
Sbjct: 52 PKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIAD 111
Query: 103 VSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVS 162
S N L+ LP QL+++ + L L ++P +G L L + L +NLL ++P S
Sbjct: 112 FSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPAS 169
Query: 163 ISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENL 198
+S L KL++L++ N + E+ D++ L NL
Sbjct: 170 LSFLVKLEQLDLGGN------DLEVLPDTLGALPNL 199
Score = 59.3 bits (142), Expect = 3e-09
Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 3/144 (2%)
Query: 34 LSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIG 93
LS+ + P I +L + L + +N + ++ ++I +NL L L N + LP S+G
Sbjct: 250 LSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLG 309
Query: 94 QMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHD 153
++T L LNV N L LP E+ + ++L N L +P L ELH + +
Sbjct: 310 KLTKLTNLNVDRNHL--EALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAG 367
Query: 154 NLLNNIPVSISKLPKLKKLNIKRN 177
N L ++P +++ L LK L + N
Sbjct: 368 NRLQSLPFALTHL-NLKALWLAEN 390
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 79.3 bits (194), Expect = 3e-15
Identities = 49/149 (32%), Positives = 85/149 (57%), Gaps = 6/149 (4%)
Query: 32 LDLSKMGITTFPKCILR---LSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKL 88
L+LS + FP+ R LSD+ + DLSRN ++P++ + +L L L+ N + L
Sbjct: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
Query: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
++G +T+L YLN+S N+L+ LP + QL +R + + N L ++P +G L L +
Sbjct: 107 NPALGNLTALTYLNLSRNQLSL--LPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQ 163
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ + N L ++P + L L+ LN++RN
Sbjct: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRN 192
Score = 57.0 bits (136), Expect = 2e-08
Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 4/138 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L+LS+ ++ P I +L + L +S N + +P I +LR LD+ SN + LP
Sbjct: 119 LNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSE 177
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
+ ++SL LNV N+L++ LP EL L +R ++ N + +P + L+ L + L
Sbjct: 178 LCGLSSLRDLNVRRNQLST--LPEELGDLPLVR-LDFSCNRVSRIPVSFCRLRHLQVILL 234
Query: 152 HDNLLNNIPVSISKLPKL 169
N L + P + KL
Sbjct: 235 DSNPLQSPPAQVCLKGKL 252
Score = 50.4 bits (119), Expect = 2e-06
Identities = 33/116 (28%), Positives = 61/116 (52%), Gaps = 3/116 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L +S + P I L + +LD+S N ++ +P + +LR L++ N + LPE
Sbjct: 141 LIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEE 200
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
+G + L+ L+ S NR++ +PV +L++++ + L N L S P + +LH
Sbjct: 201 LGDLP-LVRLDFSCNRVSR--IPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLH 253
Score = 38.5 bits (88), Expect = 0.006
Identities = 24/94 (25%), Positives = 47/94 (50%), Gaps = 1/94 (1%)
Query: 25 TFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNY 84
T ++LD+S + + P + LS + +L++ RN + +P+ + +R LD N
Sbjct: 157 TLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-LDFSCNR 215
Query: 85 IDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELK 118
+ ++P S ++ L + + +N L S V LK
Sbjct: 216 VSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLK 249
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 79.0 bits (193), Expect = 4e-15
Identities = 47/151 (31%), Positives = 82/151 (54%), Gaps = 5/151 (3%)
Query: 24 ITFDGKKRLDLSKMG---ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDL 80
I+F KRL K+ I T P I + +++ L S N + +P ++ Q LR LD+
Sbjct: 677 ISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDV 736
Query: 81 HSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTL 140
N I +P IG + +L +L+++ N++ + LP +L + +R +NLG N + S+P +
Sbjct: 737 SYNNISMIPIEIGLLQNLQHLHITGNKV--DILPKQLFKCIKLRTLNLGQNCITSLPEKV 794
Query: 141 GALKELHEVGLHDNLLNNIPVSISKLPKLKK 171
G L +L ++ L N L+ +P + + LKK
Sbjct: 795 GQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825
Score = 65.1 bits (157), Expect = 6e-11
Identities = 50/170 (29%), Positives = 83/170 (48%), Gaps = 25/170 (14%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLR---WLDLHSNYIDKL 88
L+L + P I LS++ ELDL N IR I + IS FQ+L+ L L N I +
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIIS-FQHLKRLTCLKLWHNKIVTI 698
Query: 89 PESIGQMTSLLYLNVSNNRLTS---------------------NGLPVELKQLKNIRAVN 127
P SI + +L L SNN+L S + +P+E+ L+N++ ++
Sbjct: 699 PPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLH 758
Query: 128 LGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ N +D +P L +L + L N + ++P + +L +L +L +K N
Sbjct: 759 ITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808
Score = 62.8 bits (151), Expect = 3e-10
Identities = 42/169 (24%), Positives = 88/169 (52%), Gaps = 5/169 (2%)
Query: 67 DSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAV 126
+S+ K N+ L+L + ++++P +I +++L L++ +N + + + + LK + +
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
Query: 127 NLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESE 186
L N + ++P ++ +K L + +N L ++PV++ L KL+ L++ N
Sbjct: 689 KLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI---SMIP 745
Query: 187 IFIDSIRRLENLYVVEEK-DLCAACLRKCQNARDNLNRIKNMATTTPRK 234
I I ++ L++L++ K D+ L KC R LN +N T+ P K
Sbjct: 746 IEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR-TLNLGQNCITSLPEK 793
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/155 (27%), Positives = 75/155 (48%), Gaps = 27/155 (17%)
Query: 48 RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYID--------------------- 86
++ ++ EL+L + +IP +I NL+ LDL SN I
Sbjct: 633 KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692
Query: 87 ----KLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGA 142
+P SI + +L L SNN+L S LPV + L+ +R +++ N++ +P +G
Sbjct: 693 NKIVTIPPSITHVKNLESLYFSNNKLES--LPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750
Query: 143 LKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L+ L + + N ++ +P + K KL+ LN+ +N
Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Score = 35.4 bits (80), Expect = 0.050
Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 13/185 (7%)
Query: 24 ITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSN 83
I+ + + + +L ++ P + L+D+D L L KIP IS+ NL+ +LH
Sbjct: 464 ISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQ--ELHLC 521
Query: 84 YIDKLPESIGQMTSLLYLNVSNNRLTSNG-LPVELKQLKNIRAVNL--GLNHLDSVPTTL 140
+ E +L + + T +P + LKN+R + L LN ++ L
Sbjct: 522 HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL 581
Query: 141 GALKEL-HEVGLH-DNLLNNIPVSISKL-PKLKKLNIKRNPFPKPGESEIFIDSIRRLEN 197
+L+EL H LH + L +P +I+ + P L KL I + G + ++S++++ N
Sbjct: 582 ESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHND-----GTKLLVLNSLKKMMN 636
Query: 198 LYVVE 202
+ +E
Sbjct: 637 VAELE 641
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 79.0 bits (193), Expect = 4e-15
Identities = 47/151 (31%), Positives = 82/151 (54%), Gaps = 5/151 (3%)
Query: 24 ITFDGKKRLDLSKMG---ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDL 80
I+F KRL K+ I T P I + +++ L S N + +P ++ Q LR LD+
Sbjct: 677 ISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDV 736
Query: 81 HSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTL 140
N I +P IG + +L +L+++ N++ + LP +L + +R +NLG N + S+P +
Sbjct: 737 SYNNISMIPIEIGLLQNLQHLHITGNKV--DILPKQLFKCIKLRTLNLGQNCITSLPEKV 794
Query: 141 GALKELHEVGLHDNLLNNIPVSISKLPKLKK 171
G L +L ++ L N L+ +P + + LKK
Sbjct: 795 GQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825
Score = 65.1 bits (157), Expect = 6e-11
Identities = 50/170 (29%), Positives = 83/170 (48%), Gaps = 25/170 (14%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLR---WLDLHSNYIDKL 88
L+L + P I LS++ ELDL N IR I + IS FQ+L+ L L N I +
Sbjct: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIIS-FQHLKRLTCLKLWHNKIVTI 698
Query: 89 PESIGQMTSLLYLNVSNNRLTS---------------------NGLPVELKQLKNIRAVN 127
P SI + +L L SNN+L S + +P+E+ L+N++ ++
Sbjct: 699 PPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLH 758
Query: 128 LGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ N +D +P L +L + L N + ++P + +L +L +L +K N
Sbjct: 759 ITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808
Score = 62.8 bits (151), Expect = 3e-10
Identities = 42/169 (24%), Positives = 88/169 (52%), Gaps = 5/169 (2%)
Query: 67 DSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAV 126
+S+ K N+ L+L + ++++P +I +++L L++ +N + + + + LK + +
Sbjct: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
Query: 127 NLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESE 186
L N + ++P ++ +K L + +N L ++PV++ L KL+ L++ N
Sbjct: 689 KLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI---SMIP 745
Query: 187 IFIDSIRRLENLYVVEEK-DLCAACLRKCQNARDNLNRIKNMATTTPRK 234
I I ++ L++L++ K D+ L KC R LN +N T+ P K
Sbjct: 746 IEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR-TLNLGQNCITSLPEK 793
Score = 60.1 bits (144), Expect = 2e-09
Identities = 42/155 (27%), Positives = 75/155 (48%), Gaps = 27/155 (17%)
Query: 48 RLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYID--------------------- 86
++ ++ EL+L + +IP +I NL+ LDL SN I
Sbjct: 633 KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692
Query: 87 ----KLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGA 142
+P SI + +L L SNN+L S LPV + L+ +R +++ N++ +P +G
Sbjct: 693 NKIVTIPPSITHVKNLESLYFSNNKLES--LPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750
Query: 143 LKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
L+ L + + N ++ +P + K KL+ LN+ +N
Sbjct: 751 LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Score = 35.4 bits (80), Expect = 0.050
Identities = 47/185 (25%), Positives = 87/185 (47%), Gaps = 13/185 (7%)
Query: 24 ITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSN 83
I+ + + + +L ++ P + L+D+D L L KIP IS+ NL+ +LH
Sbjct: 464 ISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQ--ELHLC 521
Query: 84 YIDKLPESIGQMTSLLYLNVSNNRLTSNG-LPVELKQLKNIRAVNL--GLNHLDSVPTTL 140
+ E +L + + T +P + LKN+R + L LN ++ L
Sbjct: 522 HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL 581
Query: 141 GALKEL-HEVGLH-DNLLNNIPVSISKL-PKLKKLNIKRNPFPKPGESEIFIDSIRRLEN 197
+L+EL H LH + L +P +I+ + P L KL I + G + ++S++++ N
Sbjct: 582 ESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHND-----GTKLLVLNSLKKMMN 636
Query: 198 LYVVE 202
+ +E
Sbjct: 637 VAELE 641
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 77.8 bits (190), Expect = 9e-15
Identities = 51/149 (34%), Positives = 85/149 (57%), Gaps = 6/149 (4%)
Query: 32 LDLSKMGITTFPKCILR---LSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKL 88
L+LS + FP+ LSD + DLS+N + ++P + F +L L+L+ N I +
Sbjct: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
Query: 89 PESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHE 148
PE+I + L YLN+S N+L++ LP L L ++ + N L S+P +G LK+L E
Sbjct: 136 PEAIVNLQMLTYLNLSRNQLSA--LPACLCGLP-LKVLIASNNKLGSLPEEIGQLKQLME 192
Query: 149 VGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ + N + +P I +L L++LN++RN
Sbjct: 193 LDVSCNEITALPQQIGQLKSLRELNVRRN 221
Score = 47.0 bits (110), Expect = 2e-05
Identities = 32/118 (27%), Positives = 63/118 (53%), Gaps = 3/118 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
K L S + + P+ I +L + ELD+S N I +P I + ++LR L++ NY+ LP
Sbjct: 168 KVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLP 227
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
+ + + L+ + S N++ +P+ +++K ++ + L N L S P + ++H
Sbjct: 228 QELVDL-PLVKFDFSCNKVLV--IPICFREMKQLQVLLLENNPLQSPPAQICTKGKVH 282
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 77.8 bits (190), Expect = 9e-15
Identities = 52/148 (35%), Positives = 81/148 (54%), Gaps = 5/148 (3%)
Query: 32 LDLSKMGITTFPKCILR--LSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
L LS + FP+ L+D DLSRN + +IP F +L L+L+ N I +P
Sbjct: 62 LSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIP 121
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
E+I + +L +LN+S N+L++ LPV L L ++ + N L S+P +G L+ L E+
Sbjct: 122 EAILNLQALTFLNISRNQLST--LPVHLCNLP-LKVLIASNNKLVSLPEEIGHLRHLMEL 178
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ N + IP I L L+ LN++RN
Sbjct: 179 DVSCNEIQTIPSQIGNLEALRDLNVRRN 206
Score = 70.1 bits (170), Expect = 2e-12
Identities = 40/140 (28%), Positives = 79/140 (56%), Gaps = 3/140 (2%)
Query: 31 RLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPE 90
R DLS+ ++ P ++ L+L +N IR IP++I Q L +L++ N + LP
Sbjct: 86 RADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPV 145
Query: 91 SIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVG 150
+ + L L SNN+L S LP E+ L+++ +++ N + ++P+ +G L+ L ++
Sbjct: 146 HLCNLP-LKVLIASNNKLVS--LPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLN 202
Query: 151 LHDNLLNNIPVSISKLPKLK 170
+ N L ++P +++LP ++
Sbjct: 203 VRRNHLVHLPEELAELPLIR 222
Score = 54.3 bits (129), Expect = 1e-07
Identities = 36/118 (30%), Positives = 65/118 (55%), Gaps = 3/118 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
K L S + + P+ I L + ELD+S N I+ IP I + LR L++ N++ LP
Sbjct: 153 KVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLP 212
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
E + ++ L+ L+ S N++T+ +PV + L++++ + L N L S P + ++H
Sbjct: 213 EELAEL-PLIRLDFSCNKITT--IPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVH 267
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 77.0 bits (188), Expect = 2e-14
Identities = 48/150 (32%), Positives = 81/150 (54%), Gaps = 2/150 (1%)
Query: 28 GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
G + L L + G+++ P I L ++ L++S N I IP IS+ N+R L ++NYI+
Sbjct: 189 GLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIEN 248
Query: 88 LPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
P + + +L L++ N+L +P L LK +R +NL N L + P L L +L
Sbjct: 249 FPSDLECLGNLEILSLGKNKL--RHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306
Query: 148 EVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
+ L NL++++P I +L L+ L + N
Sbjct: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHN 336
Score = 73.9 bits (180), Expect = 1e-13
Identities = 51/171 (29%), Positives = 84/171 (49%), Gaps = 8/171 (4%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
L+L +TTFPK + L + LDL+ NLI +P I + +NL L + N + L
Sbjct: 285 LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVE 344
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
I Q+ + L +++N+L + +++ + +R + L N L ++P + L + L
Sbjct: 345 IFQLLKIKELQLADNKL--EVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSL 402
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVE 202
DN L +P I KL L+KL++ RN K D I L N+ +E
Sbjct: 403 SDNKLTELPKYIHKLNNLRKLHVNRNNMVK------ITDCISHLNNICSLE 447
Score = 70.5 bits (171), Expect = 1e-12
Identities = 56/194 (28%), Positives = 87/194 (44%), Gaps = 38/194 (19%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIR------------------------KIPD 67
++L G+ FPK IL++ + L L +N I+ +P
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 68 SISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVN 127
I NLR L++ N+I +P+ I Q+ ++ L NN + P +L+ L N+ ++
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI--ENFPSDLECLGNLEILS 263
Query: 128 LGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN---PFPKPGE 184
LG N L +P TL +LK L + L N L P ++ LPKL L++ N PK
Sbjct: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK--- 320
Query: 185 SEIFIDSIRRLENL 198
IR L+NL
Sbjct: 321 ------EIRELKNL 328
Score = 69.7 bits (169), Expect = 2e-12
Identities = 41/140 (29%), Positives = 75/140 (53%), Gaps = 5/140 (3%)
Query: 41 TFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLY 100
TFP+ + L ++ LDLS N ++KI I + ++ L+ SN P + Q+ SL
Sbjct: 570 TFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQ 629
Query: 101 LNVS---NNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLN 157
LN+S +LT LP EL + ++ +++ N + +P +G L+ L + ++N ++
Sbjct: 630 LNISQIKGRKLTR--LPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQIS 687
Query: 158 NIPVSISKLPKLKKLNIKRN 177
+P S+ L L++LN+ N
Sbjct: 688 YLPPSLLSLNDLQQLNLSGN 707
Score = 69.3 bits (168), Expect = 3e-12
Identities = 42/141 (29%), Positives = 80/141 (56%), Gaps = 5/141 (3%)
Query: 28 GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKI---PDSISKFQNLRWLDLHSNY 84
G ++L+ S FP + +L +++L++S+ RK+ P +S L+ LD+ +N
Sbjct: 603 GIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNA 662
Query: 85 IDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALK 144
I ++P +IG++ +L+ L+ NN+++ LP L L +++ +NL N+L ++P+ + +
Sbjct: 663 IREIPRNIGELRNLVSLHAYNNQISY--LPPSLLSLNDLQQLNLSGNNLTALPSAIYNIF 720
Query: 145 ELHEVGLHDNLLNNIPVSISK 165
L E+ DN L PV I K
Sbjct: 721 SLKEINFDDNPLLRPPVEICK 741
Score = 65.5 bits (158), Expect = 5e-11
Identities = 55/185 (29%), Positives = 85/185 (45%), Gaps = 28/185 (15%)
Query: 39 ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWL-------------------- 78
I FP + L +++ L L +N +R IPD++ + LR L
Sbjct: 246 IENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKL 305
Query: 79 ---DLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDS 135
DL N I LP+ I ++ +L L + +N+LT L VE+ QL I+ + L N L+
Sbjct: 306 ISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTF--LAVEIFQLLKIKELQLADNKLEV 363
Query: 136 VPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRL 195
+ + +EL + L NLL NIP IS L+ L++ N K E +I + L
Sbjct: 364 ISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDN---KLTELPKYIHKLNNL 420
Query: 196 ENLYV 200
L+V
Sbjct: 421 RKLHV 425
Score = 62.4 bits (150), Expect = 4e-10
Identities = 56/209 (26%), Positives = 96/209 (45%), Gaps = 11/209 (5%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
++L +++ + CI L+++ L+ S N+I +P I Q + ++L N I P
Sbjct: 421 RKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ + SL YL+V+ N ++ +PV++ K + + L N L +L L +
Sbjct: 481 LGLCALDSLYYLSVNGNYISE--IPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYL 538
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEKDLCAA 209
L N + IP SIS + L L + N F E F + LENL V+ DL
Sbjct: 539 DLGKNQIKKIPASISNMISLHVLILCCNKF------ETFPRELCTLENLQVL---DLSEN 589
Query: 210 CLRKCQNARDNLNRIKNMATTTPRKTIFP 238
L+K + NL I+ + ++ + FP
Sbjct: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFP 618
Score = 59.7 bits (143), Expect = 3e-09
Identities = 35/111 (31%), Positives = 61/111 (54%), Gaps = 2/111 (1%)
Query: 39 ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSL 98
+T P + ++ + ELD+S N IR+IP +I + +NL L ++N I LP S+ + L
Sbjct: 640 LTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDL 699
Query: 99 LYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
LN+S N LT+ LP + + +++ +N N L P + K+L+ +
Sbjct: 700 QQLNLSGNNLTA--LPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTI 748
Score = 58.9 bits (141), Expect = 4e-09
Identities = 43/169 (25%), Positives = 74/169 (43%), Gaps = 21/169 (12%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
K L L+ + I ++ L L +NL++ IP+ IS L L L N + +LP
Sbjct: 352 KELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411
Query: 90 ESIGQMTSLLYLNVSNNRLTS---------------------NGLPVELKQLKNIRAVNL 128
+ I ++ +L L+V+ N + +P+E+K + I + L
Sbjct: 412 KYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIEL 471
Query: 129 GLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
N + P L AL L+ + ++ N ++ IPV IS +L L + N
Sbjct: 472 SYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSEN 520
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 76.6 bits (187), Expect = 2e-14
Identities = 46/157 (29%), Positives = 88/157 (56%), Gaps = 4/157 (2%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPES 91
+DLS +T P+C+ L + L+LS N I ++ I ++ ++ L+L N + LP +
Sbjct: 228 VDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSA 287
Query: 92 IGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGL 151
I +++ L L +++N+L +GLP + +L N+ N+L+ VP +L +L ++ L
Sbjct: 288 ICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVL 347
Query: 152 HDNLLNNIPVSISKLPKLKKLNIKRNPF----PKPGE 184
+ N L +P +I L +++ L+++ NP PKP +
Sbjct: 348 NKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
Score = 75.9 bits (185), Expect = 3e-14
Identities = 51/159 (32%), Positives = 86/159 (54%), Gaps = 4/159 (2%)
Query: 40 TTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLL 99
+ P + LS++ ++DLS N + ++P+ + +LR L+L SN I +L I Q +
Sbjct: 213 SNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVE 272
Query: 100 YLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLD--SVPTTLGALKELHEVGLHDNLLN 157
LN+S N+LTS LP + +L ++ + L N LD +P+ +G L L E +N L
Sbjct: 273 TLNLSRNQLTS--LPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLE 330
Query: 158 NIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLE 196
+P S+ + PKL+KL + +N E+ F+ I L+
Sbjct: 331 LVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLD 369
Score = 68.6 bits (166), Expect = 5e-12
Identities = 49/175 (28%), Positives = 85/175 (48%), Gaps = 5/175 (2%)
Query: 32 LDLSKMGITTFP-KCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSN-YIDKLP 89
L+LS I T P + + L+D+ LDLS N + +P + + +L+ L L+ N +
Sbjct: 132 LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQL 191
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEV 149
+ MT+L L++ + + T + LP L+ L N+ V+L N L VP L L L +
Sbjct: 192 RQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRL 251
Query: 150 GLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLENLYVVEEK 204
L N + + + I + ++ LN+ RN + I + +L+ LY+ K
Sbjct: 252 NLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSA---ICKLSKLKKLYLNSNK 303
Score = 65.9 bits (159), Expect = 3e-11
Identities = 43/132 (32%), Positives = 70/132 (53%), Gaps = 4/132 (3%)
Query: 25 TFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNY 84
T +RL+LS IT CI + ++ L+LSRN + +P +I K L+ L L+SN
Sbjct: 244 TLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNK 303
Query: 85 I--DKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGA 142
+ D LP IG++T+L +NN L +P L + +R + L NHL ++P +
Sbjct: 304 LDFDGLPSGIGKLTNLEEFMAANNNLEL--VPESLCRCPKLRKLVLNKNHLVTLPEAIHF 361
Query: 143 LKELHEVGLHDN 154
L E+ + + +N
Sbjct: 362 LTEIEVLDVREN 373
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/161 (23%), Positives = 72/161 (44%), Gaps = 24/161 (14%)
Query: 42 FPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYL 101
FP+ + ++ + L L+R + +P+ ++ Q L L + N + L + + SL +
Sbjct: 25 FPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAI 84
Query: 102 NVSNNRLTSNGL-----------------------PVELKQLKNIRAVNLGLNHLDSVPT 138
N L ++G+ P EL+ KN+ +NL N +D++P
Sbjct: 85 VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144
Query: 139 TLGA-LKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNP 178
L L +L + L +N L ++P + +L L+ L + NP
Sbjct: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNP 185
Score = 42.7 bits (99), Expect = 3e-04
Identities = 28/101 (27%), Positives = 54/101 (53%), Gaps = 8/101 (7%)
Query: 14 TLKVARNCI--------KITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKI 65
TL ++RN + K++ K L+ +K+ P I +L++++E + N + +
Sbjct: 273 TLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332
Query: 66 PDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNN 106
P+S+ + LR L L+ N++ LPE+I +T + L+V N
Sbjct: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 75.5 bits (184), Expect = 4e-14
Identities = 39/121 (32%), Positives = 73/121 (60%), Gaps = 2/121 (1%)
Query: 57 LSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVE 116
LS N + ++P+++ L +L + N + LP ++G +++L L++S N L + LP E
Sbjct: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT--LPPE 66
Query: 117 LKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKR 176
+ L ++ +NL N L S+P +L L+ L + LH NLL ++P +++LP L +L+++
Sbjct: 67 IGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRD 126
Query: 177 N 177
N
Sbjct: 127 N 127
Score = 74.3 bits (181), Expect = 1e-13
Identities = 48/140 (34%), Positives = 74/140 (52%), Gaps = 2/140 (1%)
Query: 28 GKKRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDK 87
G L LS ++ P+ + L + L ++ N ++ +P ++ L+ LDL N +D
Sbjct: 3 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 62
Query: 88 LPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELH 147
LP IG + SLL LN+++NRL S LP L L+++R + L N L SVP L L L
Sbjct: 63 LPPEIGGLGSLLELNLASNRLQS--LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
Query: 148 EVGLHDNLLNNIPVSISKLP 167
+ L DN L ++P + P
Sbjct: 121 RLDLRDNQLRDLPPELLDAP 140
Score = 52.0 bits (123), Expect = 5e-07
Identities = 32/95 (33%), Positives = 55/95 (57%), Gaps = 2/95 (2%)
Query: 30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
+RLDLS+ + T P I L + EL+L+ N ++ +P S++ ++LR L LHSN + +P
Sbjct: 51 QRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP 110
Query: 90 ESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIR 124
+ ++ L L++ +N+L LP EL +R
Sbjct: 111 ADLARLPLLTRLDLRDNQL--RDLPPELLDAPFVR 143
Score = 48.9 bits (115), Expect = 4e-06
Identities = 41/144 (28%), Positives = 60/144 (41%), Gaps = 28/144 (19%)
Query: 80 LHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTT 139
L N + +LPE++G + +L +L V++NRL ++P
Sbjct: 9 LSHNCLSELPEALGALPALTFLTVTHNRL-------------------------QTLPPA 43
Query: 140 LGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRL---E 196
LGAL L + L NLL+ +P I L L +LN+ N S + S+R L
Sbjct: 44 LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHS 103
Query: 197 NLYVVEEKDLCAACLRKCQNARDN 220
NL DL L + RDN
Sbjct: 104 NLLASVPADLARLPLLTRLDLRDN 127
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 73.2 bits (178), Expect = 2e-13
Identities = 60/201 (29%), Positives = 93/201 (46%), Gaps = 44/201 (21%)
Query: 1 MVKGEKGPKGKKITLKVARNCIKITFDGKKRLDLSKMGITTFPKCILRLSDMDELDLSRN 60
++K G K KI IT +GKK +T P + +L + L L N
Sbjct: 6 LIKALSGGKNTKI----------ITLNGKK--------MTKMPSALGKLPGLKTLVLQNN 47
Query: 61 LIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTS----------------------- 97
LI K+ + L L+L +N ++++PE + +TS
Sbjct: 48 LIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQ 107
Query: 98 -LLYLNVSNNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLL 156
L+ LN++NN LT LP E+ +LK++ +++ N L S+P L L+ L E+ L+ N L
Sbjct: 108 NLILLNLNNNHLTQ--LPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQL 165
Query: 157 NNIPVSISKLPKLKKLNIKRN 177
IP I L KL+KL + RN
Sbjct: 166 ICIPEEIKFLKKLQKLLLARN 186
Score = 46.2 bits (108), Expect = 3e-05
Identities = 45/187 (24%), Positives = 82/187 (43%), Gaps = 30/187 (16%)
Query: 63 RKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSNGLPVELKQLKN 122
R + ++S +N + + L+ + K+P ++G++ L L + NN + + EL L
Sbjct: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPK--VCPELCNLTQ 61
Query: 123 IRAVNLGLNHLDSVPTT---LGALKELHEVG---------------------LHDNLLNN 158
+ +NLG N L+ VP L +LK LH G L++N L
Sbjct: 62 LTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQ 121
Query: 159 IPVSISKLPKLKKLNIKRNPFPKPGESEIFIDSIRRLE----NLYVVEEKDLCAACLRKC 214
+P +S+L L ++I N F++++ L+ L + E+ L+K
Sbjct: 122 LPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKL 181
Query: 215 QNARDNL 221
AR+N+
Sbjct: 182 LLARNNI 188
Score = 34.3 bits (77), Expect = 0.11
Identities = 20/68 (29%), Positives = 36/68 (52%)
Query: 39 ITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSL 98
+ + P+ + L ++ EL L+ N + IP+ I + L+ L L N I LPE + + L
Sbjct: 142 LASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKL 201
Query: 99 LYLNVSNN 106
L+++ N
Sbjct: 202 RILDIAGN 209
Score = 30.0 bits (66), Expect = 2.1
Identities = 18/58 (31%), Positives = 29/58 (50%)
Query: 32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLP 89
L L+ + P+ I L + +L L+RN I +P+ + + LR LD+ N I P
Sbjct: 158 LQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFP 215
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,814,466
Number of Sequences: 37866
Number of extensions: 412605
Number of successful extensions: 2267
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 1216
Number of HSP's gapped (non-prelim): 642
length of query: 261
length of database: 18,247,518
effective HSP length: 100
effective length of query: 161
effective length of database: 14,460,918
effective search space: 2328207798
effective search space used: 2328207798
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.