Search of human proteins with 16445035

Search of human proteins with 16445035

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16445035 transglutaminase 7 [Homo sapiens]
         (710 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16445035 transglutaminase 7 [Homo sapiens]                        1452   0.0  
gi|94981556 transglutaminase 5 isoform 1 [Homo sapiens]               664   0.0  
gi|148664232 transglutaminase 6 [Homo sapiens]                        587   e-167
gi|4759230 transglutaminase 5 isoform 2 [Homo sapiens]                541   e-153
gi|39777597 transglutaminase 2 isoform a [Homo sapiens]               529   e-150
gi|189458821 transglutaminase 3 precursor [Homo sapiens]              525   e-149
gi|39777599 transglutaminase 2 isoform b [Homo sapiens]               465   e-131
gi|4507475 transglutaminase 1 [Homo sapiens]                          441   e-124
gi|156627577 transglutaminase 4 (prostate) [Homo sapiens]             420   e-117
gi|166362737 erythrocyte membrane protein band 4.2 isoform 2 [Ho...   374   e-103
gi|166362735 erythrocyte membrane protein band 4.2 isoform 1 [Ho...   374   e-103
gi|119395709 coagulation factor XIII A1 subunit precursor [Homo ...   363   e-100
gi|13491168 pumilio homolog 2 [Homo sapiens]                           30   5.9  
gi|4885615 signal transducer and activator of transcription 2 [H...    30   7.7  

>gi|16445035 transglutaminase 7 [Homo sapiens]
          Length = 710

 Score = 1452 bits (3758), Expect = 0.0
 Identities = 710/710 (100%), Positives = 710/710 (100%)

Query: 1   MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITF 60
           MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITF
Sbjct: 1   MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITF 60

Query: 61  VAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKI 120
           VAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKI
Sbjct: 61  VAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKI 120

Query: 121 EISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSW 180
           EISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSW
Sbjct: 121 EISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSW 180

Query: 181 PWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQ 240
           PWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQ
Sbjct: 181 PWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQ 240

Query: 241 GNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVV 300
           GNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVV
Sbjct: 241 GNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVV 300

Query: 301 SNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVL 360
           SNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVL
Sbjct: 301 SNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVL 360

Query: 361 DPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAH 420
           DPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAH
Sbjct: 361 DPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAH 420

Query: 421 NTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLL 480
           NTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLL
Sbjct: 421 NTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLL 480

Query: 481 ESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGG 540
           ESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGG
Sbjct: 481 ESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGG 540

Query: 541 GTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVL 600
           GTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVL
Sbjct: 541 GTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVL 600

Query: 601 KDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLG 660
           KDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLG
Sbjct: 601 KDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLG 660

Query: 661 TLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP 710
           TLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP
Sbjct: 661 TLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP 710


>gi|94981556 transglutaminase 5 isoform 1 [Homo sapiens]
          Length = 720

 Score =  664 bits (1713), Expect = 0.0
 Identities = 354/721 (49%), Positives = 448/721 (62%), Gaps = 26/721 (3%)

Query: 7   LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSF-SRPFQSQNDHITFVAETG 65
           L +   DLQSSRNN  HHT+E+ V  L VRRGQ F L L F +R FQ   D+I FV ETG
Sbjct: 5   LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVETG 64

Query: 66  PKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEISQG 125
           P P   LGTRA F L R    + W A   T  + S +VSL  P  A +G Y LKI I   
Sbjct: 65  PLPDLALGTRAVFSLARHHSPSPWIAWLETNGATSTEVSLCAPPTAAVGRYLLKIHIDSF 124

Query: 126 QGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNYG 185
           QG    Y LG FILLFNPW PED VYL SE   QEY+M DYGF+Y+G + +I   PWNYG
Sbjct: 125 QGSVTAYQLGEFILLFNPWCPEDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYG 184

Query: 186 QFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWGE 245
           QFE+ IIDIC ++L+KSL+   +PA DC+ R   VYV RVV AMINSNDDNGVL GNW E
Sbjct: 185 QFEDKIIDICLKLLDKSLHFQTDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSE 244

Query: 246 DYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFRS 305
           +Y+ G +P EW GSVAIL+QW+A G QPV+YGQCWVFA+VMCTVMRCLG+PTRV++NF S
Sbjct: 245 NYTDGANPAEWTGSVAILKQWNATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDS 304

Query: 306 AHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQ 365
            H+ D NL ID YYD    +L  +K+D IWNFHVWNECWM RKDLPP Y GWQVLD TPQ
Sbjct: 305 GHDTDGNLIIDEYYDNTGRILGNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQ 364

Query: 366 QTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSSI 425
           + S+G++CCGPASV+AI+EG+V L YDTPFV++ VNAD + WL+  G+ Q+ L  +TSS+
Sbjct: 365 EMSNGVYCCGPASVRAIKEGEVDLNYDTPFVFSMVNADCMSWLVQGGKEQK-LHQDTSSV 423

Query: 426 GKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKM-------------LGPQRA 472
           G  ISTK + SD+R  IT +YKY EGS +ER VF+KA +K+             L P R 
Sbjct: 424 GNFISTKSIQSDERDDITENYKYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRP 483

Query: 473 SLPFLD---LLESGGLRDQ---PAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIG 526
           +    D    L +  LR        L+  L   P  GQD+  +L    +           
Sbjct: 484 TSLSQDSPRSLHTPSLRPSDVVQVSLKFKLLDPPNMGQDICFVLLALNMSSQFK-----D 538

Query: 527 LVVRFCAQALLHGGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSG 586
           L V   AQ+LLH G    PFW+ T  + L   +   +P  + YS Y   L+ +KLIR+S 
Sbjct: 539 LKVNLSAQSLLHDGSPLSPFWQDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISA 598

Query: 587 IAEVEETGRSMLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLE 646
           + E + +   +LV K I L  P ++I V   A V + L + V  +N L   +  C + +E
Sbjct: 599 LGEEKSSPEKILVNKIITLSYPSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVE 658

Query: 647 GSGLINGQIAKDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTV 706
           GSGL   Q    LG L   H   I L+  P K+G RQ+Q  + SN+ K+IKGY++++V  
Sbjct: 659 GSGLFKKQQKVFLGVLKPQHQASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDF 718

Query: 707 A 707
           A
Sbjct: 719 A 719


>gi|148664232 transglutaminase 6 [Homo sapiens]
          Length = 706

 Score =  587 bits (1513), Expect = e-167
 Identities = 332/722 (45%), Positives = 442/722 (61%), Gaps = 35/722 (4%)

Query: 4   VATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITFVAE 63
           +A +R+  VD Q SRN   HHTQE     L VRRGQ F L L  SR    + + + F  E
Sbjct: 1   MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCE-EILIFTME 59

Query: 64  TGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEIS 123
           TGP+ SE L T+A F  + ++ G  W+A+       +L VSL +P +AVIG Y L I +S
Sbjct: 60  TGPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLS 119

Query: 124 QGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWN 183
             + HS    LG F+LLFNPW  EDDV+L SE   QEY++ D G +++G E+ I +  WN
Sbjct: 120 SHRKHS-NRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWN 178

Query: 184 YGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNW 243
           YGQFEEDI++IC  IL++S  H  NPA D S R++ +YV RV+SAM+NSN+D GV+QG W
Sbjct: 179 YGQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQW 238

Query: 244 GEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNF 303
              Y  G SPL W+GSVAILQ+W     +PVKYGQCWVFA V+CTV+RCLG+ TRVVSNF
Sbjct: 239 QGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNF 298

Query: 304 RSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPT 363
            SAH+ D+NL++D Y D     L     D +WNFHVWNE W  R+DL P YNGWQVLD T
Sbjct: 299 NSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDAT 358

Query: 364 PQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTS 423
           PQ+ S G+F CGPASV AIREGDVHLA+D PFV+AEVNAD + WL  + +++E +  NT 
Sbjct: 359 PQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTK 418

Query: 424 SIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLESG 483
            IG+ ISTK VGSD R  IT  YKYPEGS +ER V+ KA  ++ G + AS   + +  +G
Sbjct: 419 KIGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVE-ASGRRIWIRRAG 477

Query: 484 G---LRD---QPAQL-----QLHLARIPEWGQDLQLLL-------RIQRVPDSTHPRGPI 525
           G    RD   +PA       +  +   P  G DL+L L       R QRV    +  G  
Sbjct: 478 GRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRV--RVNLSGAT 535

Query: 526 GLVVRFCAQALLHGGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVS 585
            L  R     +LH          H VR+     +E + P+ + YS Y+  LT++K I ++
Sbjct: 536 ILYTRKPVAEILHES--------HAVRLGPQ--EEKRIPITISYSKYKEDLTEDKKILLA 585

Query: 586 GIAEVEETGRSMLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVL 645
            +  V + G  +LV KDI LE   ++I+V   A VG A+ V VT+ N L+  +  C +++
Sbjct: 586 AMCLVTK-GEKLLVEKDITLE-DFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMV 643

Query: 646 EGSGLINGQIAKDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVT 705
           EGSGL+  Q++ D+ TL       +Q D+ P+K+GPRQLQV + S    +IKG+  + V 
Sbjct: 644 EGSGLLQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVA 703

Query: 706 VA 707
            A
Sbjct: 704 TA 705


>gi|4759230 transglutaminase 5 isoform 2 [Homo sapiens]
          Length = 638

 Score =  541 bits (1393), Expect = e-153
 Identities = 281/580 (48%), Positives = 366/580 (63%), Gaps = 25/580 (4%)

Query: 147 EDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNYGQFEEDIIDICFEILNKSLYHL 206
           ED VYL SE   QEY+M DYGF+Y+G + +I   PWNYGQFE+ IIDIC ++L+KSL+  
Sbjct: 64  EDAVYLDSEPQRQEYVMNDYGFIYQGSKNWIRPCPWNYGQFEDKIIDICLKLLDKSLHFQ 123

Query: 207 KNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWGEDYSKGVSPLEWKGSVAILQQW 266
            +PA DC+ R   VYV RVV AMINSNDDNGVL GNW E+Y+ G +P EW GSVAIL+QW
Sbjct: 124 TDPATDCALRGSPVYVSRVVCAMINSNDDNGVLNGNWSENYTDGANPAEWTGSVAILKQW 183

Query: 267 SARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFRSAHNVDRNLTIDTYYDRNAEML 326
           +A G QPV+YGQCWVFA+VMCTVMRCLG+PTRV++NF S H+ D NL ID YYD    +L
Sbjct: 184 NATGCQPVRYGQCWVFAAVMCTVMRCLGIPTRVITNFDSGHDTDGNLIIDEYYDNTGRIL 243

Query: 327 STQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIREGD 386
             +K+D IWNFHVWNECWM RKDLPP Y GWQVLD TPQ+ S+G++CCGPASV+AI+EG+
Sbjct: 244 GNKKKDTIWNFHVWNECWMARKDLPPAYGGWQVLDATPQEMSNGVYCCGPASVRAIKEGE 303

Query: 387 VHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSSIGKEISTKMVGSDQRQSITSSY 446
           V L YDTPFV++ VNAD + WL+  G+ Q+ L  +TSS+G  ISTK + SD+R  IT +Y
Sbjct: 304 VDLNYDTPFVFSMVNADCMSWLVQGGKEQK-LHQDTSSVGNFISTKSIQSDERDDITENY 362

Query: 447 KYPEGSPEERAVFMKASRKM-------------LGPQRASLPFLD---LLESGGLRDQ-- 488
           KY EGS +ER VF+KA +K+             L P R +    D    L +  LR    
Sbjct: 363 KYEEGSLQERQVFLKALQKLKARSFHGSQRGAELQPSRPTSLSQDSPRSLHTPSLRPSDV 422

Query: 489 -PAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGGTQKPFW 547
               L+  L   P  GQD+  +L    +           L V   AQ+LLH G    PFW
Sbjct: 423 VQVSLKFKLLDPPNMGQDICFVLLALNMSSQFK-----DLKVNLSAQSLLHDGSPLSPFW 477

Query: 548 RHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDICLEP 607
           + T  + L   +   +P  + YS Y   L+ +KLIR+S + E + +   +LV K I L  
Sbjct: 478 QDTAFITLSPKEAKTYPCKISYSQYSQYLSTDKLIRISALGEEKSSPEKILVNKIITLSY 537

Query: 608 PHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLVAGHT 667
           P ++I V   A V + L + V  +N L   +  C + +EGSGL   Q    LG L   H 
Sbjct: 538 PSITINVLGAAVVNQPLSIQVIFSNPLSEQVEDCVLTVEGSGLFKKQQKVFLGVLKPQHQ 597

Query: 668 LQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVA 707
             I L+  P K+G RQ+Q  + SN+ K+IKGY++++V  A
Sbjct: 598 ASIILETVPFKSGQRQIQANMRSNKFKDIKGYRNVYVDFA 637



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 33/59 (55%), Positives = 38/59 (64%), Gaps = 1/59 (1%)

Query: 7  LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSF-SRPFQSQNDHITFVAET 64
          L +   DLQSSRNN  HHT+E+ V  L VRRGQ F L L F +R FQ   D+I FV ET
Sbjct: 5  LEVALTDLQSSRNNVRHHTEEITVDHLLVRRGQAFNLTLYFRNRSFQPGLDNIIFVVET 63


>gi|39777597 transglutaminase 2 isoform a [Homo sapiens]
          Length = 687

 Score =  529 bits (1362), Expect = e-150
 Identities = 294/707 (41%), Positives = 413/707 (58%), Gaps = 36/707 (5%)

Query: 7   LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFS-RPFQSQNDHITFVAETG 65
           L LE  DL+   N ++HHT ++  ++L VRRGQPF+L L F  R +++  D +TF   TG
Sbjct: 5   LVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTG 64

Query: 66  PKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEISQG 125
           P PS+  GT+A F L        W+A+       +L + L TPANA IG Y L +E S G
Sbjct: 65  PAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTG 124

Query: 126 -QGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNY 184
            QG S  + LG FILLFN W P D VYL SE   QEY++   GF+Y+G  +FI + PWN+
Sbjct: 125 YQGSS--FVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNF 182

Query: 185 GQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWG 244
           GQFE+ I+DIC  +L+ +   LKN  +DCS+R+  VYV RVVS M+N NDD GVL G W 
Sbjct: 183 GQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWD 242

Query: 245 EDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFR 304
            +Y  GVSP+ W GSV IL++W   G Q VKYGQCWVFA+V CTV+RCLG+PTRVV+N+ 
Sbjct: 243 NNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYN 302

Query: 305 SAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTP 364
           SAH+ + NL I+ Y+      +   K + IWNFH W E WM R DL PGY GWQ LDPTP
Sbjct: 303 SAHDQNSNLLIE-YFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTP 361

Query: 365 QQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSS 424
           Q+ S G +CCGP  V+AI+EGD+   YD PFV+AEVNAD V W+  D  +     + +  
Sbjct: 362 QEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLI 421

Query: 425 IGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLESGG 484
           +G +ISTK VG D+R+ IT +YKYPEGS EER  F +A+          L  L   E  G
Sbjct: 422 VGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANH---------LNKLAEKEETG 472

Query: 485 LRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGG---- 540
           +      +++ + +    G D  +   I    ++T       L++  CA+ + + G    
Sbjct: 473 M-----AMRIRVGQSMNMGSDFDVFAHI---TNNTAEEYVCRLLL--CARTVSYNGILGP 522

Query: 541 --GTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSML 598
             GT     ++ + +NL+   E   PL + Y  YR+ LT+  LI+V  +         +L
Sbjct: 523 ECGT-----KYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLL 577

Query: 599 VLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKD 658
             +D+ LE P + I +    +  + L   V+L N L VAL  CT  +EG+GL   Q   +
Sbjct: 578 AERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVE 637

Query: 659 LGTLV-AGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFV 704
           +   V AG  +++++DL P   G  +L V   S+++K +KG++++ +
Sbjct: 638 IPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVII 684


>gi|189458821 transglutaminase 3 precursor [Homo sapiens]
          Length = 693

 Score =  525 bits (1351), Expect = e-149
 Identities = 283/706 (40%), Positives = 418/706 (59%), Gaps = 20/706 (2%)

Query: 4   VATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITFVAE 63
           +A L ++S++ Q++ N + HHT +   + L +RRGQ F + +  ++   S N+ + F+  
Sbjct: 1   MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGS-NERLEFIVS 59

Query: 64  TGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEIS 123
           TGP PSE   T+A F L+    G  WSA     + N+L +S+ +PA+A IG YT+ ++I 
Sbjct: 60  TGPYPSESAMTKAVFPLSNGSSGG-WSAVLQASNGNTLTISISSPASAPIGRYTMALQIF 118

Query: 124 QGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWN 183
             QG   +  LGTFILLFNPW   D V++ +    +EY+  D G ++ G    I    WN
Sbjct: 119 S-QGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWN 177

Query: 184 YGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNW 243
           +GQFEEDI+ IC  IL++SL   ++ A D + RND  YV RV+SAMINSNDDNGVL GNW
Sbjct: 178 FGQFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNW 237

Query: 244 GEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNF 303
              Y+ G  P  W GSV IL+ W   G  PV+YGQCWVFA  + T +R LG+P+RV++NF
Sbjct: 238 SGTYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNF 297

Query: 304 RSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPT 363
            SAH+ DRNL++D YYD     L  +  D +WNFHVWNE W +R DL P Y GWQVLD T
Sbjct: 298 NSAHDTDRNLSVDVYYDPMGNPLD-KGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDAT 356

Query: 364 PQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEIL-AHNT 422
           PQ+ S G+F CGPASV  +REGDV L +D PF++AEVNAD + WL  +   ++   + N+
Sbjct: 357 PQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNS 416

Query: 423 SSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLES 482
            +IG+ ISTK VGS+ R  +T  YKYPEGS +ER VF KA    LG  + + PF     S
Sbjct: 417 HTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKA----LGKLKPNTPFA-ATSS 471

Query: 483 GGLRDQPAQL----QLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLH 538
            GL  +  +     +L +A +   G+++ L+L ++ +   T       + V   A  +++
Sbjct: 472 MGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKT-----VTVNMTAWTIIY 526

Query: 539 GGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSML 598
            G      W+ +  M+LD  +E + P+ + Y+ Y   L  + +IR++ + +V +    ++
Sbjct: 527 NGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDES-EVV 585

Query: 599 VLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKD 658
           V +DI L+ P L++EV   A V K + V +  +N L   +  C +++EGSGL+ G +  D
Sbjct: 586 VERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKID 645

Query: 659 LGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFV 704
           + TL      +++ D+ P+++G +QL    S N+   IK    I V
Sbjct: 646 VPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPAIKAMLSIDV 691


>gi|39777599 transglutaminase 2 isoform b [Homo sapiens]
          Length = 548

 Score =  465 bits (1196), Expect = e-131
 Identities = 233/459 (50%), Positives = 301/459 (65%), Gaps = 5/459 (1%)

Query: 7   LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFS-RPFQSQNDHITFVAETG 65
           L LE  DL+   N ++HHT ++  ++L VRRGQPF+L L F  R +++  D +TF   TG
Sbjct: 5   LVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTG 64

Query: 66  PKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEISQG 125
           P PS+  GT+A F L        W+A+       +L + L TPANA IG Y L +E S G
Sbjct: 65  PAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTG 124

Query: 126 -QGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWNY 184
            QG S  + LG FILLFN W P D VYL SE   QEY++   GF+Y+G  +FI + PWN+
Sbjct: 125 YQGSS--FVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNF 182

Query: 185 GQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWG 244
           GQFE+ I+DIC  +L+ +   LKN  +DCS+R+  VYV RVVS M+N NDD GVL G W 
Sbjct: 183 GQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWD 242

Query: 245 EDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFR 304
            +Y  GVSP+ W GSV IL++W   G Q VKYGQCWVFA+V CTV+RCLG+PTRVV+N+ 
Sbjct: 243 NNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYN 302

Query: 305 SAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPTP 364
           SAH+ + NL I+ Y+      +   K + IWNFH W E WM R DL PGY GWQ LDPTP
Sbjct: 303 SAHDQNSNLLIE-YFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTP 361

Query: 365 QQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTSS 424
           Q+ S G +CCGP  V+AI+EGD+   YD PFV+AEVNAD V W+  D  +     + +  
Sbjct: 362 QEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLI 421

Query: 425 IGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKAS 463
           +G +ISTK VG D+R+ IT +YKYPEGS EER  F +A+
Sbjct: 422 VGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRAN 460


>gi|4507475 transglutaminase 1 [Homo sapiens]
          Length = 817

 Score =  441 bits (1135), Expect = e-124
 Identities = 266/709 (37%), Positives = 373/709 (52%), Gaps = 33/709 (4%)

Query: 7   LRLESVDLQSSR---NNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITFVAE 63
           L +  VDL SSR   N +EHHT E     L VRRGQPF++ L  SR ++S +D IT    
Sbjct: 110 LVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYES-SDRITLELL 168

Query: 64  TGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIG--HYTLKIE 121
            G  P    GT     + +   G  W A        +L + + T  NA+IG   +T++ +
Sbjct: 169 IGNNPEVGKGTHVIIPVGKGGSGG-WKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQ 227

Query: 122 ISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWP 181
              G+      P     +LFNPW PED VY+  E   QEY++ + G +Y G E  I    
Sbjct: 228 SDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERT 287

Query: 182 WNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQG 241
           WNYGQF+  ++D C       LY L         R D V V RV+SAM+NS DDNGVL G
Sbjct: 288 WNYGQFDHGVLDAC-------LYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIG 340

Query: 242 NWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVS 301
           NW  DYS+G +P  W GSV IL  +  R G  V YGQCWVFA V  TV+RCLG+ TR V+
Sbjct: 341 NWSGDYSRGTNPSAWVGSVEILLSY-LRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVT 399

Query: 302 NFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLD 361
           NF SAH+ D +LT+D Y+D N + L     D +WNFHVWN+CWM R DLP G++GWQV+D
Sbjct: 400 NFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVD 459

Query: 362 PTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHN 421
            TPQ+TSSG+FCCGP SV++I+ G V++ YDTPF++AEVN+D+V W   D  + +I+   
Sbjct: 460 ATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVE 519

Query: 422 TSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLE 481
             +IG  I TK + S+ R+ IT  YK+PEGS  ER     A+     P   +        
Sbjct: 520 EKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYA-------N 572

Query: 482 SGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGG 541
            G   D   Q++   A+    GQDL + + +       H      + +        + G 
Sbjct: 573 RGSAEDVAMQVE---AQDAVMGQDLMVSVML-----INHSSSRRTVKLHLYLSVTFYTGV 624

Query: 542 TQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLK 601
           +   F      + L  G   +  + + Y  YR  L D+  + ++    V+E+G+ +    
Sbjct: 625 SGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQH 684

Query: 602 DICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGT 661
              L  P LS+ +   A VG+   V +   N L V L++    LEGSGL   +I  ++G 
Sbjct: 685 TFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKIL-NVGD 743

Query: 662 LVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP 710
           +    T+ ++    P + GPRQL   + S ++ ++ G   I V VA AP
Sbjct: 744 IGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGV--IQVDVAPAP 790


>gi|156627577 transglutaminase 4 (prostate) [Homo sapiens]
          Length = 684

 Score =  420 bits (1080), Expect = e-117
 Identities = 254/711 (35%), Positives = 364/711 (51%), Gaps = 35/711 (4%)

Query: 1   MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITF 60
           MD    L++  +D  +  N   HHT E        RRGQ F+LRL  ++P QS +  +  
Sbjct: 2   MDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVLNQPLQSYHQ-LKL 60

Query: 61  VAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKI 120
              TGP PS    T              W A+        + V++ +  NA++G Y L +
Sbjct: 61  EFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNV 120

Query: 121 EISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSW 180
           +      H +        LLFNPW  ED V++P E   +EYI+ D G  Y G  R I   
Sbjct: 121 KTGN---HILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCK 177

Query: 181 PWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQ 240
           PWN+GQFE++++D C  +L +S       +   + R D V VCR + AM++     GVL 
Sbjct: 178 PWNFGQFEKNVLDCCISLLTES-------SLKPTDRRDPVLVCRAMCAMMSFEKGQGVLI 230

Query: 241 GNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVV 300
           GNW  DY  G +P +W GS  ILQQ+     Q V +GQCWVFA ++ TV+R LG+P R V
Sbjct: 231 GNWTGDYEGGTAPYKWTGSAPILQQYY-NTKQAVCFGQCWVFAGILTTVLRALGIPARSV 289

Query: 301 SNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVL 360
           + F SAH+ +RNLT+DTY + N E +++   D +WNFHVW + WM R DLP GY+GWQ +
Sbjct: 290 TGFDSAHDTERNLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAV 349

Query: 361 DPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQE---I 417
           D TPQ+ S G+FCCGP+ + AIR+GD+ + YDT FV++EVN D +IWL+     QE   +
Sbjct: 350 DATPQERSQGVFCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHV 409

Query: 418 LAHNTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFL 477
           ++  T+SIGK ISTK VG D+R+ IT  YKYPEGS EER V   A   +   +    P  
Sbjct: 410 ISMETTSIGKNISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREHRRPVK 469

Query: 478 DLLESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALL 537
           +      ++     L          G  +   + ++R    T     + ++  F  Q  L
Sbjct: 470 ENFLHMSVQSDDVLL----------GNSVNFTVILKR---KTAALQNVNILGSFELQ--L 514

Query: 538 HGGGTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLT---DEKLIRVSGIAEVEETG 594
           + G              +  G+ ++  L L    Y N L    DE +IR   IAE+ E+ 
Sbjct: 515 YTGKKMAKLCDLNKTSQIQ-GQVSEVTLTLDSKTYINSLAILDDEPVIRGFIIAEIVESK 573

Query: 595 RSMLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQ 654
             M        + P  SIE+     +G+ L  +    NTL + L+     LE  G+ + Q
Sbjct: 574 EIMASEVFTSFQYPEFSIELPNTGRIGQLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQ 633

Query: 655 IAKDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVT 705
              D GT+  G T+Q Q+   P K GP++  V +SS +VKEI   K + +T
Sbjct: 634 -TSDHGTVQPGETIQSQIKCTPIKTGPKKFIVKLSSKQVKEINAQKIVLIT 683


>gi|166362737 erythrocyte membrane protein band 4.2 isoform 2 [Homo
           sapiens]
          Length = 691

 Score =  374 bits (960), Expect = e-103
 Identities = 229/701 (32%), Positives = 362/701 (51%), Gaps = 24/701 (3%)

Query: 7   LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRP---FQSQNDHITFVAE 63
           L ++S D Q++RNN+EHHT+ +  +RL VRRGQPF + L F  P   F      +   A+
Sbjct: 5   LGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVALTAQ 64

Query: 64  TGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEIS 123
           TG +PS++  T+ATF ++ +     WSA     D+ S  +S+ TPA+AVIGHY+L +++S
Sbjct: 65  TGEQPSKINRTQATFPISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYSLLLQVS 124

Query: 124 QGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWN 183
            G+   +   LG F LLFNPW+ ED V+L +E    EY++   G +Y G    I +  W+
Sbjct: 125 -GRKQLL---LGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAESWD 180

Query: 184 YGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNW 243
           +GQFE D+ID+   +L+K         K   + +  V+V RV+ A+++   +  VL    
Sbjct: 181 FGQFEGDVIDLSLRLLSKD--------KQVEKWSQPVHVARVLGALLHFLKEQRVLPTPQ 232

Query: 244 GEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNF 303
            +   +G    + +GSV IL+QW    G+PV  GQ WV A+V CTV+RCLG+P RVV+ F
Sbjct: 233 TQATQEGALLNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTF 292

Query: 304 RSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPT 363
            SA      L ID YY+         +R +IW F    ECWM R  LP GY+GWQ+L P+
Sbjct: 293 ASAQGTGGRLLIDEYYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQGYDGWQILHPS 352

Query: 364 PQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTS 423
                  L  C    V+A++EG + L      ++A +NA  V+W   +    E+   NT 
Sbjct: 353 APNGGGVLGSCDLVPVRAVKEGTLGLTPAVSDLFAAINASCVVWKCCEDGTLELTDSNTK 412

Query: 424 SIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLESG 483
            +G  ISTK VGSD+ + IT +YKYPEGS +E+ V  +  ++ +  ++ +      LE+ 
Sbjct: 413 YVGNNISTKGVGSDRCEDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETA 472

Query: 484 GLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGGTQ 543
                P  L L          D Q+ + +       H      + +    QA+ + G   
Sbjct: 473 ----SPLYLLLKAPSSLPLRGDAQISVTL-----VNHSEQEKAVQLAIGVQAVHYNGVLA 523

Query: 544 KPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDI 603
              WR  + + L    E    + L +SN+     +   +R++ +A   E+  S    +DI
Sbjct: 524 AKLWRKKLHLTLSANLEKIITIGLFFSNFERNPPENTFLRLTAMATHSESNLSCFAQEDI 583

Query: 604 CLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLV 663
            +  PHL+I++ E+AE  + L   V+L N+L   +  C + + G GLI+ + +    ++ 
Sbjct: 584 AICRPHLAIKMPEKAEQYQPLTASVSLQNSLDAPMEDCVISILGRGLIHRERSYRFRSVW 643

Query: 664 AGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFV 704
             +T+  +    PT  G ++L V +  N  + +  YK + V
Sbjct: 644 PENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTV 684


>gi|166362735 erythrocyte membrane protein band 4.2 isoform 1 [Homo
           sapiens]
          Length = 721

 Score =  374 bits (960), Expect = e-103
 Identities = 229/701 (32%), Positives = 362/701 (51%), Gaps = 24/701 (3%)

Query: 7   LRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRP---FQSQNDHITFVAE 63
           L ++S D Q++RNN+EHHT+ +  +RL VRRGQPF + L F  P   F      +   A+
Sbjct: 35  LGIKSCDFQAARNNEEHHTKALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKVALTAQ 94

Query: 64  TGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEIS 123
           TG +PS++  T+ATF ++ +     WSA     D+ S  +S+ TPA+AVIGHY+L +++S
Sbjct: 95  TGEQPSKINRTQATFPISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYSLLLQVS 154

Query: 124 QGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWPWN 183
            G+   +   LG F LLFNPW+ ED V+L +E    EY++   G +Y G    I +  W+
Sbjct: 155 -GRKQLL---LGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAESWD 210

Query: 184 YGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNW 243
           +GQFE D+ID+   +L+K         K   + +  V+V RV+ A+++   +  VL    
Sbjct: 211 FGQFEGDVIDLSLRLLSKD--------KQVEKWSQPVHVARVLGALLHFLKEQRVLPTPQ 262

Query: 244 GEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNF 303
            +   +G    + +GSV IL+QW    G+PV  GQ WV A+V CTV+RCLG+P RVV+ F
Sbjct: 263 TQATQEGALLNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTF 322

Query: 304 RSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLDPT 363
            SA      L ID YY+         +R +IW F    ECWM R  LP GY+GWQ+L P+
Sbjct: 323 ASAQGTGGRLLIDEYYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQGYDGWQILHPS 382

Query: 364 PQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAHNTS 423
                  L  C    V+A++EG + L      ++A +NA  V+W   +    E+   NT 
Sbjct: 383 APNGGGVLGSCDLVPVRAVKEGTLGLTPAVSDLFAAINASCVVWKCCEDGTLELTDSNTK 442

Query: 424 SIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLLESG 483
            +G  ISTK VGSD+ + IT +YKYPEGS +E+ V  +  ++ +  ++ +      LE+ 
Sbjct: 443 YVGNNISTKGVGSDRCEDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETA 502

Query: 484 GLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGGGTQ 543
                P  L L          D Q+ + +       H      + +    QA+ + G   
Sbjct: 503 ----SPLYLLLKAPSSLPLRGDAQISVTL-----VNHSEQEKAVQLAIGVQAVHYNGVLA 553

Query: 544 KPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDI 603
              WR  + + L    E    + L +SN+     +   +R++ +A   E+  S    +DI
Sbjct: 554 AKLWRKKLHLTLSANLEKIITIGLFFSNFERNPPENTFLRLTAMATHSESNLSCFAQEDI 613

Query: 604 CLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLV 663
            +  PHL+I++ E+AE  + L   V+L N+L   +  C + + G GLI+ + +    ++ 
Sbjct: 614 AICRPHLAIKMPEKAEQYQPLTASVSLQNSLDAPMEDCVISILGRGLIHRERSYRFRSVW 673

Query: 664 AGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFV 704
             +T+  +    PT  G ++L V +  N  + +  YK + V
Sbjct: 674 PENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLTNYKSVTV 714


>gi|119395709 coagulation factor XIII A1 subunit precursor [Homo
           sapiens]
          Length = 732

 Score =  363 bits (931), Expect = e-100
 Identities = 228/706 (32%), Positives = 355/706 (50%), Gaps = 37/706 (5%)

Query: 7   LRLESVDLQSSR---NNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITFVAE 63
           L + SV L   R   N  +HHT +    +L VRRGQ FY+++ FSRP+  + D       
Sbjct: 46  LNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYV 105

Query: 64  TGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKIEIS 123
            G  P E  GT     +        W A     +  S+++S+ +    ++G + + + + 
Sbjct: 106 IGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVW 165

Query: 124 QGQG--HSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSWP 181
              G   +   P     +LFNPW  +D VYL +E   +EY++ D G ++ G    I +  
Sbjct: 166 TPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRS 225

Query: 182 WNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQG 241
           W+YGQFE+ I+D C       LY +     D S R + + V RV SAM+N+ DD GVL G
Sbjct: 226 WSYGQFEDGILDTC-------LYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVG 278

Query: 242 NWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVS 301
           +W   Y+ GV P  W GSV IL ++ +    PV+YGQCWVFA V  T +RCLG+P R+V+
Sbjct: 279 SWDNIYAYGVPPSAWTGSVDILLEYRS-SENPVRYGQCWVFAGVFNTFLRCLGIPARIVT 337

Query: 302 NFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVLD 361
           N+ SAH+ D NL +D + + +  + S   +D +WN+H WNE WM R DLP G+ GWQ +D
Sbjct: 338 NYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVD 397

Query: 362 PTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAH- 420
            TPQ+ S G++ CGPASV+AI+ G V   +D PFV+AEVN+D +I++        ++ + 
Sbjct: 398 STPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSD-LIYITAKKDGTHVVENV 456

Query: 421 NTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLL 480
           + + IGK I TK +G D    IT +YK+ EG  EER     A   M G ++        L
Sbjct: 457 DATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETA--LMYGAKKP-------L 507

Query: 481 ESGGLRDQPAQLQLHL-ARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHG 539
            + G+    + + +         G+D +L +  +   +++H R  I       A    + 
Sbjct: 508 NTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFR---NNSHNRYTI--TAYLSANITFYT 562

Query: 540 GGTQKPFWRHTVRMNLD---FGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRS 596
           G  +  F + T  + L+   F KE    +L+    Y  +L ++  +     A + ET   
Sbjct: 563 GVPKAEFKKETFDVTLEPLSFKKEA---VLIQAGEYMGQLLEQASLHFFVTARINETRDV 619

Query: 597 MLVLKDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIA 656
           +   K   L  P + I+V     VG  + V V  TN L   L +  + L+G G +   + 
Sbjct: 620 LAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPG-VTRPMK 678

Query: 657 KDLGTLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDI 702
           K    +    T+Q +    P  +G R+L   +SS+ ++ + G  D+
Sbjct: 679 KMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDV 724


>gi|13491168 pumilio homolog 2 [Homo sapiens]
          Length = 1064

 Score = 30.4 bits (67), Expect = 5.9
 Identities = 25/95 (26%), Positives = 38/95 (40%), Gaps = 2/95 (2%)

Query: 350 LPPGYNGWQVLDPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLL 409
           L  G  G+QVL PT     +G    GP +   +    V L   TP + +   A       
Sbjct: 425 LATGMPGYQVLAPTAYYDQTGALVVGPGARTGL-GAPVRLMAPTPVLISSAAAQAAAAAA 483

Query: 410 GDGQAQEILAHNTSSIGKEISTKMVGSDQRQSITS 444
             G A   L  +T+ + + I T+     Q+Q  T+
Sbjct: 484 AGGTASS-LTGSTNGLFRPIGTQPPQQQQQQPSTN 517


>gi|4885615 signal transducer and activator of transcription 2 [Homo
           sapiens]
          Length = 851

 Score = 30.0 bits (66), Expect = 7.7
 Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 6/81 (7%)

Query: 48  SRPFQSQNDHITFVAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFT 107
           ++P   Q  H   + +TG K      T  T  L R+Q GN     + +ID N  Q+  F 
Sbjct: 320 TQPCMPQTPHRPLILKTGSK-----FTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGFR 374

Query: 108 PANAVIGHY-TLKIEISQGQG 127
             N +  +  TL  E  Q QG
Sbjct: 375 KFNILTSNQKTLTPEKGQSQG 395


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,708,061
Number of Sequences: 37866
Number of extensions: 1281733
Number of successful extensions: 2455
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2392
Number of HSP's gapped (non-prelim): 16
length of query: 710
length of database: 18,247,518
effective HSP length: 109
effective length of query: 601
effective length of database: 14,120,124
effective search space: 8486194524
effective search space used: 8486194524
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.