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Search of human proteins with 163659899
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|163659899 insulin-like growth factor 1 isoform 1
preproprotein [Homo sapiens]
(158 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|163659899 insulin-like growth factor 1 isoform 1 preproprotei... 331 2e-91
gi|163659903 insulin-like growth factor 1 isoform 3 preproprotei... 317 2e-87
gi|11024682 insulin-like growth factor 1 isoform 4 preproprotein... 282 1e-76
gi|163659901 insulin-like growth factor 1 isoform 2 preproprotei... 236 5e-63
gi|4504609 insulin-like growth factor 2 isoform 1 precursor [Hom... 94 6e-20
gi|108796063 insulin-like growth factor 2 isoform 1 precursor [H... 94 6e-20
gi|189083846 insulin-like growth factor 2 isoform 2 [Homo sapiens] 94 6e-20
gi|4557671 proinsulin precursor [Homo sapiens] 49 1e-06
gi|109148522 insulin- insulin-like growth factor 2 [Homo sapiens] 37 0.007
gi|5902052 relaxin 1 preproprotein [Homo sapiens] 29 1.9
gi|27883882 P18SRP protein [Homo sapiens] 29 1.9
gi|5016090 nuclear receptor subfamily 0, group B, member 1 [Homo... 28 2.5
gi|56786157 activating transcription factor 6 [Homo sapiens] 28 3.3
gi|53729363 leucine rich repeat and sterile alpha motif containi... 28 3.3
gi|53729361 leucine rich repeat and sterile alpha motif containi... 28 3.3
gi|53729359 leucine rich repeat and sterile alpha motif containi... 28 3.3
gi|4508045 zona pellucida glycoprotein 2 preproprotein [Homo sap... 28 3.3
gi|23943882 serine/threonine kinase 33 [Homo sapiens] 28 4.3
gi|239748384 PREDICTED: hypothetical protein XP_002346651 [Homo ... 27 7.3
gi|239742312 PREDICTED: hypothetical protein XP_002342488 [Homo ... 27 7.3
gi|149944433 hampin [Homo sapiens] 27 7.3
gi|154689866 hypothetical protein LOC9778 [Homo sapiens] 27 7.3
gi|154689751 hypothetical protein LOC9778 [Homo sapiens] 27 7.3
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 27 7.3
gi|38049014 semenogelin I isoform b preproprotein [Homo sapiens] 27 9.5
gi|4506883 semenogelin I isoform a preproprotein [Homo sapiens] 27 9.5
gi|46048171 MAS-related GPR, member X3 [Homo sapiens] 27 9.5
>gi|163659899 insulin-like growth factor 1 isoform 1 preproprotein
[Homo sapiens]
Length = 158
Score = 331 bits (848), Expect = 2e-91
Identities = 158/158 (100%), Positives = 158/158 (100%)
Query: 1 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 60
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
Sbjct: 1 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 60
Query: 61 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 120
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
Sbjct: 61 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 120
Query: 121 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK 158
VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK
Sbjct: 121 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK 158
>gi|163659903 insulin-like growth factor 1 isoform 3 preproprotein
[Homo sapiens]
Length = 195
Score = 317 bits (813), Expect = 2e-87
Identities = 151/151 (100%), Positives = 151/151 (100%)
Query: 1 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 60
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
Sbjct: 1 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 60
Query: 61 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 120
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
Sbjct: 61 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 120
Query: 121 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKG 151
VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKG
Sbjct: 121 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKG 151
>gi|11024682 insulin-like growth factor 1 isoform 4 preproprotein
[Homo sapiens]
Length = 153
Score = 282 bits (721), Expect = 1e-76
Identities = 134/134 (100%), Positives = 134/134 (100%)
Query: 1 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 60
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
Sbjct: 1 MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD 60
Query: 61 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 120
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
Sbjct: 61 ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS 120
Query: 121 VRAQRHTDMPKTQK 134
VRAQRHTDMPKTQK
Sbjct: 121 VRAQRHTDMPKTQK 134
>gi|163659901 insulin-like growth factor 1 isoform 2 preproprotein
[Homo sapiens]
Length = 137
Score = 236 bits (603), Expect = 5e-63
Identities = 113/113 (100%), Positives = 113/113 (100%)
Query: 22 VKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGS 81
VKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGS
Sbjct: 6 VKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGS 65
Query: 82 SSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQK 134
SSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQK
Sbjct: 66 SSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQK 118
>gi|4504609 insulin-like growth factor 2 isoform 1 precursor [Homo
sapiens]
Length = 180
Score = 93.6 bits (231), Expect = 6e-20
Identities = 53/91 (58%), Positives = 58/91 (63%), Gaps = 12/91 (13%)
Query: 37 LCLLTFTSSATA------GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTG 90
L LLTF + A+ ETLCG ELVD LQFVCGDRGFYF++P S R G
Sbjct: 10 LVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSR----G 65
Query: 91 IVDECCFRSCDLRRLEMYCAPLKPAKSARSV 121
IV+ECCFRSCDL LE YCA PAKS R V
Sbjct: 66 IVEECCFRSCDLALLETYCA--TPAKSERDV 94
>gi|108796063 insulin-like growth factor 2 isoform 1 precursor [Homo
sapiens]
Length = 180
Score = 93.6 bits (231), Expect = 6e-20
Identities = 53/91 (58%), Positives = 58/91 (63%), Gaps = 12/91 (13%)
Query: 37 LCLLTFTSSATA------GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTG 90
L LLTF + A+ ETLCG ELVD LQFVCGDRGFYF++P S R G
Sbjct: 10 LVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSR----G 65
Query: 91 IVDECCFRSCDLRRLEMYCAPLKPAKSARSV 121
IV+ECCFRSCDL LE YCA PAKS R V
Sbjct: 66 IVEECCFRSCDLALLETYCA--TPAKSERDV 94
>gi|189083846 insulin-like growth factor 2 isoform 2 [Homo sapiens]
Length = 236
Score = 93.6 bits (231), Expect = 6e-20
Identities = 53/91 (58%), Positives = 58/91 (63%), Gaps = 12/91 (13%)
Query: 37 LCLLTFTSSATA------GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTG 90
L LLTF + A+ ETLCG ELVD LQFVCGDRGFYF++P S R G
Sbjct: 66 LVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSR----G 121
Query: 91 IVDECCFRSCDLRRLEMYCAPLKPAKSARSV 121
IV+ECCFRSCDL LE YCA PAKS R V
Sbjct: 122 IVEECCFRSCDLALLETYCA--TPAKSERDV 150
>gi|4557671 proinsulin precursor [Homo sapiens]
Length = 110
Score = 49.3 bits (116), Expect = 1e-06
Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 23/80 (28%)
Query: 53 LCGAELVDALQFVCGDRGFYFNKPT----------------GYGSSSRR-------APQT 89
LCG+ LV+AL VCG+RGF++ T G G+ S + +
Sbjct: 30 LCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR 89
Query: 90 GIVDECCFRSCDLRRLEMYC 109
GIV++CC C L +LE YC
Sbjct: 90 GIVEQCCTSICSLYQLENYC 109
>gi|109148522 insulin- insulin-like growth factor 2 [Homo sapiens]
Length = 200
Score = 37.0 bits (84), Expect = 0.007
Identities = 14/25 (56%), Positives = 19/25 (76%)
Query: 53 LCGAELVDALQFVCGDRGFYFNKPT 77
LCG+ LV+AL VCG+RGF++ T
Sbjct: 30 LCGSHLVEALYLVCGERGFFYTPKT 54
>gi|5902052 relaxin 1 preproprotein [Homo sapiens]
Length = 185
Score = 28.9 bits (63), Expect = 1.9
Identities = 10/29 (34%), Positives = 14/29 (48%)
Query: 81 SSSRRAPQTGIVDECCFRSCDLRRLEMYC 109
S +R P + ++CC C R L YC
Sbjct: 157 SQKKRRPYVALFEKCCLIGCTKRSLAKYC 185
>gi|27883882 P18SRP protein [Homo sapiens]
Length = 155
Score = 28.9 bits (63), Expect = 1.9
Identities = 15/46 (32%), Positives = 21/46 (45%)
Query: 113 KPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK 158
K +S S + T K QKYQ K KS+ +KG ++ K
Sbjct: 90 KRKRSYSSSSTEEDTSKQKKQKYQKKEKKKEKKSKSKKGKHHKKEK 135
>gi|5016090 nuclear receptor subfamily 0, group B, member 1 [Homo
sapiens]
Length = 470
Score = 28.5 bits (62), Expect = 2.5
Identities = 27/103 (26%), Positives = 39/103 (37%), Gaps = 16/103 (15%)
Query: 11 LFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRG 70
L++CCFC + H S + Y L T A A PE G DR
Sbjct: 129 LYRCCFCG----EDHPRQGS-ILYSLLTSSKQTHVAPAAPEARPGG--------AWWDRS 175
Query: 71 FYFNKPTGYGSSSRRAPQTGIVDECCFRSCD--LRRLEMYCAP 111
++ +P G + T ++ CCF D + +YC P
Sbjct: 176 YFAQRPGG-KEALPGGRATALLYRCCFCGEDHPQQGSTLYCVP 217
>gi|56786157 activating transcription factor 6 [Homo sapiens]
Length = 670
Score = 28.1 bits (61), Expect = 3.3
Identities = 15/57 (26%), Positives = 28/57 (49%)
Query: 100 CDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEE 156
C ++ ++ PL PA S+ SV + R D + ++ P + ++ SQ S + E
Sbjct: 81 CTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGE 137
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 28.1 bits (61), Expect = 3.3
Identities = 11/30 (36%), Positives = 16/30 (53%)
Query: 50 PETLCGAELVDALQFVCGDRGFYFNKPTGY 79
P +CGA LQF+C + G + P+ Y
Sbjct: 189 PREVCGAGTAAILQFLCKESGLEYYPPSQY 218
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 28.1 bits (61), Expect = 3.3
Identities = 11/30 (36%), Positives = 16/30 (53%)
Query: 50 PETLCGAELVDALQFVCGDRGFYFNKPTGY 79
P +CGA LQF+C + G + P+ Y
Sbjct: 189 PREVCGAGTAAILQFLCKESGLEYYPPSQY 218
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 28.1 bits (61), Expect = 3.3
Identities = 11/30 (36%), Positives = 16/30 (53%)
Query: 50 PETLCGAELVDALQFVCGDRGFYFNKPTGY 79
P +CGA LQF+C + G + P+ Y
Sbjct: 189 PREVCGAGTAAILQFLCKESGLEYYPPSQY 218
>gi|4508045 zona pellucida glycoprotein 2 preproprotein [Homo
sapiens]
Length = 745
Score = 28.1 bits (61), Expect = 3.3
Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 5/57 (8%)
Query: 20 LKVKMHTMSSSHLFYLALCLLTF-----TSSATAGPETLCGAELVDALQFVCGDRGF 71
LK K+ H FYLA LTF T S PE LC + + +C GF
Sbjct: 321 LKTKLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGF 377
>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
Length = 514
Score = 27.7 bits (60), Expect = 4.3
Identities = 15/39 (38%), Positives = 20/39 (51%)
Query: 120 SVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEERK 158
SVR +M K K P S +NT ++ K ST E+ K
Sbjct: 388 SVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLK 426
>gi|239748384 PREDICTED: hypothetical protein XP_002346651 [Homo
sapiens]
Length = 246
Score = 26.9 bits (58), Expect = 7.3
Identities = 12/30 (40%), Positives = 14/30 (46%)
Query: 109 CAPLKPAKSARSVRAQRHTDMPKTQKYQPP 138
C P KPA+ R R T P + QPP
Sbjct: 169 CGPEKPARIENPERPCRRTPAPGAPRLQPP 198
>gi|239742312 PREDICTED: hypothetical protein XP_002342488 [Homo
sapiens]
Length = 246
Score = 26.9 bits (58), Expect = 7.3
Identities = 12/30 (40%), Positives = 14/30 (46%)
Query: 109 CAPLKPAKSARSVRAQRHTDMPKTQKYQPP 138
C P KPA+ R R T P + QPP
Sbjct: 169 CGPEKPARIENPERPCRRTPAPGAPRLQPP 198
>gi|149944433 hampin [Homo sapiens]
Length = 351
Score = 26.9 bits (58), Expect = 7.3
Identities = 28/115 (24%), Positives = 42/115 (36%), Gaps = 16/115 (13%)
Query: 54 CGAELVDALQ------FVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRR--- 104
C EL + Q F CG G + + +GS+ R+ P + E F +
Sbjct: 41 CQPELSETSQTLPPKPFSCGRSGKGHKRKSPFGSTERKTPVKKLAPE--FSKVKTKTPKH 98
Query: 105 ---LEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPP--STNKNTKSQRRKGSTF 154
E C L R +R+Q + P++ PP ST + S K F
Sbjct: 99 SPIKEEPCGSLSETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAF 153
>gi|154689866 hypothetical protein LOC9778 [Homo sapiens]
Length = 1395
Score = 26.9 bits (58), Expect = 7.3
Identities = 13/45 (28%), Positives = 21/45 (46%)
Query: 113 KPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEER 157
K S V +R +++P T + S +KN K + T EE+
Sbjct: 223 KDCNSESEVTKERSSEVPTTVHEKTQSKSKNEKENKFSNGTIEEK 267
>gi|154689751 hypothetical protein LOC9778 [Homo sapiens]
Length = 1395
Score = 26.9 bits (58), Expect = 7.3
Identities = 13/45 (28%), Positives = 21/45 (46%)
Query: 113 KPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGSTFEER 157
K S V +R +++P T + S +KN K + T EE+
Sbjct: 223 KDCNSESEVTKERSSEVPTTVHEKTQSKSKNEKENKFSNGTIEEK 267
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 26.9 bits (58), Expect = 7.3
Identities = 14/49 (28%), Positives = 25/49 (51%)
Query: 98 RSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKS 146
R CDL E+ + A+ +R Q+ + Q+ Q PS++K+ +S
Sbjct: 295 RPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRS 343
>gi|38049014 semenogelin I isoform b preproprotein [Homo sapiens]
Length = 402
Score = 26.6 bits (57), Expect = 9.5
Identities = 13/33 (39%), Positives = 18/33 (54%)
Query: 121 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGST 153
V A H K+Q+Y + +K TKSQR G +
Sbjct: 71 VDANDHDQSRKSQQYDLNALHKTTKSQRHLGGS 103
>gi|4506883 semenogelin I isoform a preproprotein [Homo sapiens]
Length = 462
Score = 26.6 bits (57), Expect = 9.5
Identities = 13/33 (39%), Positives = 18/33 (54%)
Query: 121 VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGST 153
V A H K+Q+Y + +K TKSQR G +
Sbjct: 71 VDANDHDQSRKSQQYDLNALHKTTKSQRHLGGS 103
>gi|46048171 MAS-related GPR, member X3 [Homo sapiens]
Length = 322
Score = 26.6 bits (57), Expect = 9.5
Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 6/64 (9%)
Query: 6 SLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFV 65
SL + + FCDFL ++ ++ + L F LCG+ LV ++ +
Sbjct: 150 SLLRSILEWMFCDFLFSGADSVWCETSDFITIAWLVFLCVV------LCGSSLVLLVRIL 203
Query: 66 CGDR 69
CG R
Sbjct: 204 CGSR 207
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.133 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,330,120
Number of Sequences: 37866
Number of extensions: 261372
Number of successful extensions: 690
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 661
Number of HSP's gapped (non-prelim): 30
length of query: 158
length of database: 18,247,518
effective HSP length: 94
effective length of query: 64
effective length of database: 14,688,114
effective search space: 940039296
effective search space used: 940039296
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 57 (26.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.