Guide to the Human Genome
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Search of human proteins with 16332362

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins)
isoform 4 [Homo sapiens]
         (737 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1476   0.0  
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1468   0.0  
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1467   0.0  
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1463   0.0  
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1461   0.0  
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]   1445   0.0  
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]   1441   0.0  
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      362   e-100
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      303   4e-82
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]      290   3e-78
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      288   1e-77
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   271   1e-72
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        270   3e-72
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             254   2e-67
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           252   8e-67
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    248   1e-65
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    248   1e-65
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   246   7e-65
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   246   7e-65
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   241   2e-63
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   240   3e-63
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   240   4e-63
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        239   5e-63
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          239   5e-63
gi|169161522 PREDICTED: similar to cell division cycle 2-like 1 ...   235   1e-61
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        234   2e-61
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    230   3e-60
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 229   9e-60
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]                   229   9e-60

>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 1476 bits (3821), Expect = 0.0
 Identities = 737/737 (100%), Positives = 737/737 (100%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 61  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
           EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 61  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120

Query: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 180
           DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK
Sbjct: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 180

Query: 181 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 240
           VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE
Sbjct: 181 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 240

Query: 241 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300
           SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS
Sbjct: 241 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300

Query: 301 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 360
           EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL
Sbjct: 301 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 360

Query: 361 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420
           KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF
Sbjct: 361 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420

Query: 421 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 480
           PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE
Sbjct: 421 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 480

Query: 481 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 540
           VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV
Sbjct: 481 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 540

Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
           VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS
Sbjct: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600

Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
           EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL
Sbjct: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660

Query: 661 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 720
           KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT
Sbjct: 661 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 720

Query: 721 TTNQGASAAGPGFSLKF 737
           TTNQGASAAGPGFSLKF
Sbjct: 721 TTNQGASAAGPGFSLKF 737


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 1468 bits (3801), Expect = 0.0
 Identities = 733/737 (99%), Positives = 734/737 (99%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94

Query: 61  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
           EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 95  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 154

Query: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 180
           DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK
Sbjct: 155 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 214

Query: 181 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 240
           VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE
Sbjct: 215 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 274

Query: 241 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300
           SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS
Sbjct: 275 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 334

Query: 301 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 360
           EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL
Sbjct: 335 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 394

Query: 361 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420
           KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF
Sbjct: 395 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 454

Query: 421 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 480
           PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE
Sbjct: 455 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 514

Query: 481 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 540
           VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV
Sbjct: 515 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 574

Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
           VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS
Sbjct: 575 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634

Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
           EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL
Sbjct: 635 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694

Query: 661 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 720
           KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT
Sbjct: 695 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 754

Query: 721 TTNQGASAAGPGFSLKF 737
           TTNQGASAAGPGFSLKF
Sbjct: 755 TTNQGASAAGPGFSLKF 771


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 1467 bits (3799), Expect = 0.0
 Identities = 737/748 (98%), Positives = 737/748 (98%), Gaps = 11/748 (1%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 61  EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 109
           EKVHHRKDEKRKEK           KHARVKEKEREHERRKRHREEQDKARREWERQKRR
Sbjct: 61  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 120

Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169
           EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 121 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 180

Query: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 229
           HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 240

Query: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 289
           KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 241 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 300

Query: 290 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 349
           SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 301 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 360

Query: 350 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 409
           PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 361 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 420

Query: 410 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 469
           RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 421 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 480

Query: 470 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 529
           ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 481 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 540

Query: 530 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 589
           GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI
Sbjct: 541 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 600

Query: 590 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 649
           NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 601 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 660

Query: 650 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 709
           PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 661 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 720

Query: 710 DDLKETGFHLTTTNQGASAAGPGFSLKF 737
           DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 DDLKETGFHLTTTNQGASAAGPGFSLKF 748


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 1463 bits (3787), Expect = 0.0
 Identities = 734/748 (98%), Positives = 735/748 (98%), Gaps = 11/748 (1%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           +  SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35  LKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94

Query: 61  EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 109
           EKVHHRKDEKRKEK           KHARVKEKEREHERRKRHREEQDKARREWERQKRR
Sbjct: 95  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 154

Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169
           EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 155 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 214

Query: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 229
           HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 215 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 274

Query: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 289
           KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 275 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 334

Query: 290 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 349
           SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 335 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 394

Query: 350 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 409
           PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 395 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 454

Query: 410 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 469
           RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 455 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 514

Query: 470 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 529
           ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 515 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 574

Query: 530 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 589
           GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI
Sbjct: 575 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 634

Query: 590 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 649
           NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 635 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 694

Query: 650 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 709
           PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 695 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 754

Query: 710 DDLKETGFHLTTTNQGASAAGPGFSLKF 737
           DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 755 DDLKETGFHLTTTNQGASAAGPGFSLKF 782


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 1461 bits (3781), Expect = 0.0
 Identities = 733/746 (98%), Positives = 734/746 (98%), Gaps = 9/746 (1%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94

Query: 61  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
           EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 95  EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 154

Query: 121 ---------DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 171
                    DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR
Sbjct: 155 GNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 214

Query: 172 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 231
           TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT
Sbjct: 215 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 274

Query: 232 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 291
           SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA
Sbjct: 275 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 334

Query: 292 EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 351
           EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD
Sbjct: 335 EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 394

Query: 352 SPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL 411
           SPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL
Sbjct: 395 SPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL 454

Query: 412 KMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMET 471
           KMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMET
Sbjct: 455 KMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMET 514

Query: 472 MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGS 531
           MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGS
Sbjct: 515 MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGS 574

Query: 532 PLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINK 591
           PLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINK
Sbjct: 575 PLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINK 634

Query: 592 VFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 651
           VFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG
Sbjct: 635 VFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 694

Query: 652 RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDD 711
           RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDD
Sbjct: 695 RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDD 754

Query: 712 LKETGFHLTTTNQGASAAGPGFSLKF 737
           LKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 755 LKETGFHLTTTNQGASAAGPGFSLKF 780


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 1445 bits (3741), Expect = 0.0
 Identities = 726/738 (98%), Positives = 728/738 (98%), Gaps = 3/738 (0%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94

Query: 61  EKVHHRKDEKRKEK-KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 119
           EKVHHRKDEKRKEK KHARVKE  REHERRKRHREEQDKARREWERQKRREMAREHSRRE
Sbjct: 95  EKVHHRKDEKRKEKWKHARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRE 152

Query: 120 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 179
           RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD
Sbjct: 153 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 212

Query: 180 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 239
           KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA
Sbjct: 213 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 272

Query: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
           ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM
Sbjct: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332

Query: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIE 359
           SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIE
Sbjct: 333 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 392

Query: 360 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 419
           LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG
Sbjct: 393 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 452

Query: 420 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 479
           FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
Sbjct: 453 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512

Query: 480 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 539
           EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV
Sbjct: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 572

Query: 540 VVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP 599
           VVT WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTP
Sbjct: 573 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 632

Query: 600 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 659
           SEKIWPGYSELP VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG
Sbjct: 633 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 692

Query: 660 LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL 719
           LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL
Sbjct: 693 LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL 752

Query: 720 TTTNQGASAAGPGFSLKF 737
           TTTNQGASAAGPGFSLKF
Sbjct: 753 TTTNQGASAAGPGFSLKF 770


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 1441 bits (3731), Expect = 0.0
 Identities = 726/748 (97%), Positives = 728/748 (97%), Gaps = 13/748 (1%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           +  SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35  LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94

Query: 61  EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 109
           EKVHHRKDEKRKEK           KHARVKE  REHERRKRHREEQDKARREWERQKRR
Sbjct: 95  EKVHHRKDEKRKEKCRHHSHSAEGGKHARVKE--REHERRKRHREEQDKARREWERQKRR 152

Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169
           EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 153 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 212

Query: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 229
           HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 213 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 272

Query: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 289
           KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 273 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 332

Query: 290 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 349
           SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 333 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 392

Query: 350 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 409
           PDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 393 PDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 452

Query: 410 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 469
           RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 453 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 512

Query: 470 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 529
           ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 513 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 572

Query: 530 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 589
           GSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQI
Sbjct: 573 GSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQI 632

Query: 590 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 649
           NKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 633 NKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 692

Query: 650 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 709
           PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 693 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 752

Query: 710 DDLKETGFHLTTTNQGASAAGPGFSLKF 737
           DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 753 DDLKETGFHLTTTNQGASAAGPGFSLKF 780


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 212 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 271
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60

Query: 272 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 331
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120

Query: 332 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 391
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180

Query: 392 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 451
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240

Query: 452 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 511
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300

Query: 512 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 571
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360

Query: 572 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 631
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420

Query: 632 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 691
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480

Query: 692 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 737
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 39/192 (20%), Positives = 67/192 (34%), Gaps = 24/192 (12%)

Query: 57  MSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS 116
           M  ++ +   +D    E+K +  +    E        EE+++   E           E S
Sbjct: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE-----------EGS 49

Query: 117 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED 176
             E           E E +  E+++E+ E       A E+  E  +  E+S       E+
Sbjct: 50  TSE-----------ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 98

Query: 177 YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 236
           +   V  S + R          E+G+G    +   + E D + D   +S  E K    + 
Sbjct: 99  HLLVVPESRFDRDSGESEEAEEEVGEGTP--QSSALTEGDYVPDSPALSPIELKQELPKY 156

Query: 237 SSAESGSGSEEE 248
             A  G  S EE
Sbjct: 157 LPALQGCRSVEE 168



 Score = 31.2 bits (69), Expect = 3.6
 Identities = 28/122 (22%), Positives = 48/122 (39%), Gaps = 8/122 (6%)

Query: 37  DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 96
           D + D  +  DS       + S  E     ++E+ +E++     E+E      +   EE+
Sbjct: 5   DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE-----EEEEGSTSEESEEEEE 59

Query: 97  DKARREWERQKRREMAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRA 153
           ++   E E     E A E S     E +  E  ER+ E    +  + +  R+  E E   
Sbjct: 60  EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAE 119

Query: 154 EE 155
           EE
Sbjct: 120 EE 121


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  362 bits (928), Expect = e-100
 Identities = 176/327 (53%), Positives = 240/327 (73%), Gaps = 6/327 (1%)

Query: 374 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 433
           CRSV+EF+ LNRI EGTYG+VYRA+D +TDEIVALK+++M+KEK+G PI+SLREI  +L+
Sbjct: 33  CRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLR 92

Query: 434 AQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVK 493
            +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M  PF   +VK +++Q+LRG++
Sbjct: 93  LRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQ 152

Query: 494 HLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLG 553
           +LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P+K  TP VVTLWYRAPELLLG
Sbjct: 153 YLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLG 212

Query: 554 AKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAV 613
               +T++DMW+VGCI  ELL  +PL PG SEI QI+ + + LGTPSE IWPG+S+LP V
Sbjct: 213 TTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLV 272

Query: 614 KKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPID 673
            + +  + PYNNL+ +F   LS+ G  L++    Y P +R +A D L+  YF+E PLP +
Sbjct: 273 GQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 331

Query: 674 PSMFPTWPAKSEQQRVKRGTSPRPPEG 700
           P + PT+P      R KR  +P   EG
Sbjct: 332 PELMPTFP----HHRNKR-AAPATSEG 353


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  303 bits (776), Expect = 4e-82
 Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)

Query: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 653 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 700
           R +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282


>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
          Length = 283

 Score =  290 bits (743), Expect = 3e-78
 Identities = 145/288 (50%), Positives = 200/288 (69%), Gaps = 12/288 (4%)

Query: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++         
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLF------ 233

Query: 653 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 700
             +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 234 MATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 276


>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  288 bits (738), Expect = 1e-77
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 653 RISAEDGLKHEYFRETPL 670
           R +A D L+  YF+E PL
Sbjct: 240 RATAGDCLESSYFKEKPL 257


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  271 bits (694), Expect = 1e-72
 Identities = 136/290 (46%), Positives = 202/290 (69%), Gaps = 5/290 (1%)

Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
           ++ FQ + +I EGTYGVVY+AK+++T ++VALK+++++ E EG P T++REI+ + + +H
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 495
           PNIV + ++V   N  K+Y+V  ++  DLK  M++     LP   +K+ + QLL+GV   
Sbjct: 61  PNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFC 118

Query: 496 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 555
           H + ++HRDLK  NLL++  G +K+ DFGLAR +G PL+ YT  VVTLWYRAPE+LLG+K
Sbjct: 119 HSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSK 178

Query: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
            Y+TAVD+WS+GCIF E++T+K LFPG SEIDQ+ ++F+ LGTPSE  WPG ++LP  K 
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG 238

Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 665
            +F +     L +     L  +G DL+ + L Y P +RI+A+  L H YF
Sbjct: 239 -SFPKWTRKGL-EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  270 bits (691), Expect = 3e-72
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 495
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118

Query: 496 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 555
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178

Query: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238

Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 672
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  254 bits (649), Expect = 2e-67
 Identities = 124/297 (41%), Positives = 197/297 (66%), Gaps = 14/297 (4%)

Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 490
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 491 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 550
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT  VVTLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174

Query: 551 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 610
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 611 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 667
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  252 bits (644), Expect = 8e-67
 Identities = 122/297 (41%), Positives = 196/297 (65%), Gaps = 14/297 (4%)

Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 490
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 491 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 550
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT   +TLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEV 174

Query: 551 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 610
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 611 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 667
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  248 bits (633), Expect = 1e-65
 Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)

Query: 29   RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 86
            R+  Y R  S E  G+   S     P   S  R+ +  +    +R  K  +R     R  
Sbjct: 366  RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420

Query: 87   ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 142
              R RHR  + ++R           +  +A E ++ ++ R  +  R  E  +     +  
Sbjct: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480

Query: 143  QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 202
            +   K  +        +       SA      +D   K+K  H + SP      + +   
Sbjct: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538

Query: 203  GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262
             + P++  K+E   ++         ++ T  A     ES S + +EE    +E+ +  T 
Sbjct: 539  TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589

Query: 263  EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 322
                +E+E+       T              +  E+   D  R N +   V         
Sbjct: 590  SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634

Query: 323  SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 372
              E E+    +    P    L  GD +  SP      + +  K+      P+Y    +  
Sbjct: 635  KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694

Query: 373  ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
               G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 695  IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754

Query: 430  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
             + +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 755  ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814

Query: 482  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
            K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V
Sbjct: 815  KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874

Query: 541  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 875  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934

Query: 601  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
              +WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L
Sbjct: 935  PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993

Query: 661  KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 691
            + E+ R+  P  + P   P W    E    KR
Sbjct: 994  QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)

Query: 59  RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 114
           R+ +   R+  + +     R KE+ REH RR   R      + ++R     ++R E+A+ 
Sbjct: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248

Query: 115 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 167
            S      RR+            ++R  +  +   +  KE     +E  K  RE + E  
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308

Query: 168 AHHRTM-------RED--YSDKVKASHWSRSPPRP 193
           A+ R         R+D   S +   S  SR  P P
Sbjct: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343



 Score = 33.5 bits (75), Expect = 0.73
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 106 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 159
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 160 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 204
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 205 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 264
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 265 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 324
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 325 ES 326
           +S
Sbjct: 408 KS 409



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 47/246 (19%), Positives = 75/246 (30%), Gaps = 20/246 (8%)

Query: 77  ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 136
           +R     + H  R +  +E   A +E  +  R +     + R R  L  L  + +     
Sbjct: 270 SRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSH 329

Query: 137 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS-------------DKVKA 183
           R  Q  +  +             R   R  S + R     YS                 +
Sbjct: 330 RASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389

Query: 184 SHW--SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 241
           S W  SRSP  P   R      R P        R        +S S  + SS   S+   
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSR----SRHRLSRSRSRHSSISPSTLTL 445

Query: 242 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 301
            S S   E  + ++      +  +E  +  E  +  E  + + +AS  S       E S 
Sbjct: 446 KS-SLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSA 504

Query: 302 DEEREN 307
              + N
Sbjct: 505 SASQTN 510


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  248 bits (633), Expect = 1e-65
 Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)

Query: 29   RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 86
            R+  Y R  S E  G+   S     P   S  R+ +  +    +R  K  +R     R  
Sbjct: 366  RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420

Query: 87   ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 142
              R RHR  + ++R           +  +A E ++ ++ R  +  R  E  +     +  
Sbjct: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480

Query: 143  QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 202
            +   K  +        +       SA      +D   K+K  H + SP      + +   
Sbjct: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538

Query: 203  GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262
             + P++  K+E   ++         ++ T  A     ES S + +EE    +E+ +  T 
Sbjct: 539  TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589

Query: 263  EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 322
                +E+E+       T              +  E+   D  R N +   V         
Sbjct: 590  SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634

Query: 323  SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 372
              E E+    +    P    L  GD +  SP      + +  K+      P+Y    +  
Sbjct: 635  KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694

Query: 373  ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
               G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 695  IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754

Query: 430  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
             + +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 755  ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814

Query: 482  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
            K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V
Sbjct: 815  KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874

Query: 541  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 875  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934

Query: 601  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
              +WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L
Sbjct: 935  PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993

Query: 661  KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 691
            + E+ R+  P  + P   P W    E    KR
Sbjct: 994  QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)

Query: 59  RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 114
           R+ +   R+  + +     R KE+ REH RR   R      + ++R     ++R E+A+ 
Sbjct: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248

Query: 115 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 167
            S      RR+            ++R  +  +   +  KE     +E  K  RE + E  
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308

Query: 168 AHHRTM-------RED--YSDKVKASHWSRSPPRP 193
           A+ R         R+D   S +   S  SR  P P
Sbjct: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343



 Score = 33.5 bits (75), Expect = 0.73
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 106 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 159
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 160 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 204
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 205 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 264
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 265 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 324
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 325 ES 326
           +S
Sbjct: 408 KS 409



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 47/246 (19%), Positives = 75/246 (30%), Gaps = 20/246 (8%)

Query: 77  ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 136
           +R     + H  R +  +E   A +E  +  R +     + R R  L  L  + +     
Sbjct: 270 SRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSH 329

Query: 137 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS-------------DKVKA 183
           R  Q  +  +             R   R  S + R     YS                 +
Sbjct: 330 RASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389

Query: 184 SHW--SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 241
           S W  SRSP  P   R      R P        R        +S S  + SS   S+   
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSR----SRHRLSRSRSRHSSISPSTLTL 445

Query: 242 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 301
            S S   E  + ++      +  +E  +  E  +  E  + + +AS  S       E S 
Sbjct: 446 KS-SLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSA 504

Query: 302 DEEREN 307
              + N
Sbjct: 505 SASQTN 510


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  246 bits (627), Expect = 7e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 325  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 371
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 372  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 430  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 482  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 541  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 601  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 661  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 693
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 694  -------SPRPPEGGLGYSQLGDDD 711
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 44/200 (22%), Positives = 79/200 (39%), Gaps = 18/200 (9%)

Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQRE-----QKERERRAEERRKEREARR 164
           +MA +  RRE D     +R     +    Q +  R+     Q E+E+  E   K    + 
Sbjct: 86  DMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145

Query: 165 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 224
            +S   +   E+  D  KA   ++S  +  R         K  KE+  +ER+L S  +D 
Sbjct: 146 RISGSSKRSNEETDDYGKA-QVAKSSSKESR-------SSKLHKEKTRKERELKSGHKDR 197

Query: 225 SDSERKTSSAES----SSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 280
           S S RK  + +S     S +  S S   +  +  ++++ S S  S  ++ +       T 
Sbjct: 198 SKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDD-SPSGASYGQDYDLSPSRSHTS 256

Query: 281 SNSEEASEQSAEEVSEEEMS 300
           SN +   +        + +S
Sbjct: 257 SNYDSYKKSPGSTSRRQSVS 276



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 23/230 (10%)

Query: 35  REDSMEDRGEEDDSLAIKPPQQMSRKE----KVHHRKDEKRKEKKHARVKEKEREHERRK 90
           R ++ E RG +      K      R+     K    + EK +E        K+R     K
Sbjct: 93  RRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSK 152

Query: 91  RHREEQDK------ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 144
           R  EE D       A+   +  +  ++ +E +R+ER+ L+   + R +  + RE  K  +
Sbjct: 153 RSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE-LKSGHKDRSKSHRKRETPKSYK 211

Query: 145 --EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR---SPPRPPRERFE 199
             +  +R  R+  R+    ++++ S    +  +DY      SH S    S  + P     
Sbjct: 212 TVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSR 271

Query: 200 LGDGRKPVKEEKMEERDLLSD------LQDISD-SERKTSSAESSSAESG 242
                 P KE    +    S        + +S  S R++SS E S + SG
Sbjct: 272 RQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG 321



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 83/394 (21%), Positives = 130/394 (32%), Gaps = 65/394 (16%)

Query: 35  REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKERE-----HERR 89
           +  SM+DR       + +      + +       E R  K H     KERE      +R 
Sbjct: 139 KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRS 198

Query: 90  KRHRE-EQDKARREWERQKRREMAREHSRRERDRLEQ--------------LERKRERER 134
           K HR+ E  K+ +  +  KRR  +R   R+  D  +Q              L   R    
Sbjct: 199 KSHRKRETPKSYKTVDSPKRR--SRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTS 256

Query: 135 KMREQQKEQREQKERERRAEERRKEREA------------RREVSAHHRTMREDYSDKVK 182
              +  K+      R +      KE  A            RR+ S    + R   S +  
Sbjct: 257 SNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316

Query: 183 ASHWSRSPPRPPRER------FELGDGRKPV---KEEKMEERDLLSDLQDISDSERKTSS 233
            S+  RSP    R R       +    R P+   K  K   R         S S++K SS
Sbjct: 317 GSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSS 376

Query: 234 AESSSA---------ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE-----EEEEEEET 279
           + S  +          S  G+E   +++E      +   + +E +        +E     
Sbjct: 377 SRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVE 436

Query: 280 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE------V 333
             +S   S++    V  E+ + D E  N  HL    ++  D    + +E  E+       
Sbjct: 437 AKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLK 496

Query: 334 GEGTPQSS--ALTEGDYVPDSPALSPIELKQELP 365
            +GT  S   AL E    P     S  E    LP
Sbjct: 497 AQGTRDSKPIALKEEIVTPKETETSEKETPPPLP 530



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 48/223 (21%), Positives = 83/223 (37%), Gaps = 26/223 (11%)

Query: 90  KRHREEQDKARREWERQKRREMAREHS-RRERDRLEQLERKRERERKMREQ--------- 139
           K  R E D+ RR  +R  R    R H  RR RD L+  + ++E+ +++  +         
Sbjct: 90  KLDRRENDE-RRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRIS 148

Query: 140 --QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 197
              K   E+ +   +A+  +   +  R    H    R++   ++K+ H  RS     RE 
Sbjct: 149 GSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKE--RELKSGHKDRSKSHRKRET 206

Query: 198 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE-----SGSGSEEEEEEE 252
                  K  K     +R   S  +  SDS ++  S   +S       S S S      +
Sbjct: 207 ------PKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYD 260

Query: 253 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 295
             ++  GSTS         +E    ++ + S     +    VS
Sbjct: 261 SYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVS 303



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 38/231 (16%), Positives = 89/231 (38%), Gaps = 12/231 (5%)

Query: 41  DRGEEDDSLAIKPPQQMSRKEKVH-HRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA 99
           DR E D+       +   R +++H HR  + R+ +   + K+ E+E  +    +    K 
Sbjct: 92  DRRENDER------RGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145

Query: 100 RREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE 159
           R     ++  E   ++ + +  +    E +  +  K + +++ + +   ++R    R++E
Sbjct: 146 RISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRE 205

Query: 160 R-EARREVSAHHRTMREDYSDKVKASHWSRSPPRPP-RERFELGDGRKPVK---EEKMEE 214
             ++ + V +  R  R  +     +S    SP      + ++L   R       +   + 
Sbjct: 206 TPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKS 265

Query: 215 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 265
               S  Q +S   ++ S+ +SS+      S  +           S+ E S
Sbjct: 266 PGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  246 bits (627), Expect = 7e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 325  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 371
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 372  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 430  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 482  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 541  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 601  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 661  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 693
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 694  -------SPRPPEGGLGYSQLGDDD 711
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 44/200 (22%), Positives = 79/200 (39%), Gaps = 18/200 (9%)

Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQRE-----QKERERRAEERRKEREARR 164
           +MA +  RRE D     +R     +    Q +  R+     Q E+E+  E   K    + 
Sbjct: 86  DMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145

Query: 165 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 224
            +S   +   E+  D  KA   ++S  +  R         K  KE+  +ER+L S  +D 
Sbjct: 146 RISGSSKRSNEETDDYGKA-QVAKSSSKESR-------SSKLHKEKTRKERELKSGHKDR 197

Query: 225 SDSERKTSSAES----SSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 280
           S S RK  + +S     S +  S S   +  +  ++++ S S  S  ++ +       T 
Sbjct: 198 SKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDD-SPSGASYGQDYDLSPSRSHTS 256

Query: 281 SNSEEASEQSAEEVSEEEMS 300
           SN +   +        + +S
Sbjct: 257 SNYDSYKKSPGSTSRRQSVS 276



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 23/230 (10%)

Query: 35  REDSMEDRGEEDDSLAIKPPQQMSRKE----KVHHRKDEKRKEKKHARVKEKEREHERRK 90
           R ++ E RG +      K      R+     K    + EK +E        K+R     K
Sbjct: 93  RRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSK 152

Query: 91  RHREEQDK------ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 144
           R  EE D       A+   +  +  ++ +E +R+ER+ L+   + R +  + RE  K  +
Sbjct: 153 RSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE-LKSGHKDRSKSHRKRETPKSYK 211

Query: 145 --EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR---SPPRPPRERFE 199
             +  +R  R+  R+    ++++ S    +  +DY      SH S    S  + P     
Sbjct: 212 TVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSR 271

Query: 200 LGDGRKPVKEEKMEERDLLSD------LQDISD-SERKTSSAESSSAESG 242
                 P KE    +    S        + +S  S R++SS E S + SG
Sbjct: 272 RQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG 321



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 83/394 (21%), Positives = 130/394 (32%), Gaps = 65/394 (16%)

Query: 35  REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKERE-----HERR 89
           +  SM+DR       + +      + +       E R  K H     KERE      +R 
Sbjct: 139 KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRS 198

Query: 90  KRHRE-EQDKARREWERQKRREMAREHSRRERDRLEQ--------------LERKRERER 134
           K HR+ E  K+ +  +  KRR  +R   R+  D  +Q              L   R    
Sbjct: 199 KSHRKRETPKSYKTVDSPKRR--SRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTS 256

Query: 135 KMREQQKEQREQKERERRAEERRKEREA------------RREVSAHHRTMREDYSDKVK 182
              +  K+      R +      KE  A            RR+ S    + R   S +  
Sbjct: 257 SNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316

Query: 183 ASHWSRSPPRPPRER------FELGDGRKPV---KEEKMEERDLLSDLQDISDSERKTSS 233
            S+  RSP    R R       +    R P+   K  K   R         S S++K SS
Sbjct: 317 GSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSS 376

Query: 234 AESSSA---------ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE-----EEEEEEET 279
           + S  +          S  G+E   +++E      +   + +E +        +E     
Sbjct: 377 SRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVE 436

Query: 280 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE------V 333
             +S   S++    V  E+ + D E  N  HL    ++  D    + +E  E+       
Sbjct: 437 AKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLK 496

Query: 334 GEGTPQSS--ALTEGDYVPDSPALSPIELKQELP 365
            +GT  S   AL E    P     S  E    LP
Sbjct: 497 AQGTRDSKPIALKEEIVTPKETETSEKETPPPLP 530



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 48/223 (21%), Positives = 83/223 (37%), Gaps = 26/223 (11%)

Query: 90  KRHREEQDKARREWERQKRREMAREHS-RRERDRLEQLERKRERERKMREQ--------- 139
           K  R E D+ RR  +R  R    R H  RR RD L+  + ++E+ +++  +         
Sbjct: 90  KLDRRENDE-RRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRIS 148

Query: 140 --QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 197
              K   E+ +   +A+  +   +  R    H    R++   ++K+ H  RS     RE 
Sbjct: 149 GSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKE--RELKSGHKDRSKSHRKRET 206

Query: 198 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE-----SGSGSEEEEEEE 252
                  K  K     +R   S  +  SDS ++  S   +S       S S S      +
Sbjct: 207 ------PKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYD 260

Query: 253 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 295
             ++  GSTS         +E    ++ + S     +    VS
Sbjct: 261 SYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVS 303



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 38/231 (16%), Positives = 89/231 (38%), Gaps = 12/231 (5%)

Query: 41  DRGEEDDSLAIKPPQQMSRKEKVH-HRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA 99
           DR E D+       +   R +++H HR  + R+ +   + K+ E+E  +    +    K 
Sbjct: 92  DRRENDER------RGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145

Query: 100 RREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE 159
           R     ++  E   ++ + +  +    E +  +  K + +++ + +   ++R    R++E
Sbjct: 146 RISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRE 205

Query: 160 R-EARREVSAHHRTMREDYSDKVKASHWSRSPPRPP-RERFELGDGRKPVK---EEKMEE 214
             ++ + V +  R  R  +     +S    SP      + ++L   R       +   + 
Sbjct: 206 TPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKS 265

Query: 215 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 265
               S  Q +S   ++ S+ +SS+      S  +           S+ E S
Sbjct: 266 PGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 373 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 432
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243

Query: 433 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 491
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300

Query: 492 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 551
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 552 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 611
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420

Query: 612 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 666
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  240 bits (613), Expect = 3e-63
 Identities = 130/336 (38%), Positives = 198/336 (58%), Gaps = 16/336 (4%)

Query: 378 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKM---EKEKEGFPITSLREINTILKA 434
           + ++ L+ + EG +  VY+A+DK T++IVA+K++K+    + K+G   T+LREI  + + 
Sbjct: 10  KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69

Query: 435 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKH 494
            HPNI+ + +     +   I +V +++E DL+ +++       P  +K  M+  L+G+++
Sbjct: 70  SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 495 LHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGA 554
           LH +WILHRDLK +NLLL   G+LK+ DFGLA+ +GSP +AYT  VVT WYRAPELL GA
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 555 KEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVK 614
           + Y   VDMW+VGCI  ELL + P  PG S++DQ+ ++F+ LGTP+E+ WP    LP   
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP--D 245

Query: 615 KMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDP 674
            +TF   P   L   F A   D   DL+     + P  RI+A   LK +YF   P P   
Sbjct: 246 YVTFKSFPGIPLHHIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304

Query: 675 SMF--PTWPAKSEQQR------VKRGTSPRPPEGGL 702
                P  P ++ +++      +KR  +    +GGL
Sbjct: 305 CQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL 340


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  240 bits (612), Expect = 4e-63
 Identities = 122/292 (41%), Positives = 186/292 (63%), Gaps = 5/292 (1%)

Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
           +++++ L +I EGTYG V++AK+++T EIVALKR++++ + EG P ++LREI  + + +H
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496
            NIV + +++      K+ +V  + + DLK   ++      P  VK+ + QLL+G+   H
Sbjct: 61  KNIVRLHDVLHSDK--KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118

Query: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 556
              +LHRDLK  NLL++  G LK+ DFGLAR +G P++ Y+  VVTLWYR P++L GAK 
Sbjct: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178

Query: 557 YSTAVDMWSVGCIFGELLTQ-KPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
           YST++DMWS GCIF EL    +PLFPG    DQ+ ++F+ LGTP+E+ WP  ++LP  K 
Sbjct: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237

Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 667
             +  +P           L+  G DL+   L   P +RISAE+ L+H YF +
Sbjct: 238 -PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  239 bits (611), Expect = 5e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100

Query: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 358
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147

Query: 359 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 416
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207

Query: 417 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 476
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264

Query: 477 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 536
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324

Query: 537 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 596
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384

Query: 597 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 656
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443

Query: 657 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 694
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  239 bits (611), Expect = 5e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 35  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94

Query: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 358
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 95  SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141

Query: 359 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 416
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201

Query: 417 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 476
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258

Query: 477 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 536
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318

Query: 537 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 596
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378

Query: 597 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 656
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437

Query: 657 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 694
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480


>gi|169161522 PREDICTED: similar to cell division cycle 2-like 1
           (PITSLRE proteins) [Homo sapiens]
          Length = 155

 Score =  235 bits (600), Expect = 1e-61
 Identities = 116/121 (95%), Positives = 117/121 (96%), Gaps = 1/121 (0%)

Query: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
           +  SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35  LKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94

Query: 61  EKVHHRKDEKRKEK-KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 119
           EK HHRKDEKRKEK KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE
Sbjct: 95  EKAHHRKDEKRKEKRKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 154

Query: 120 R 120
           R
Sbjct: 155 R 155



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 33/168 (19%), Positives = 67/168 (39%), Gaps = 18/168 (10%)

Query: 127 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 186
           E+   + + + E  +E++ +KE+E +AE +R +    R+      + R+   +     H 
Sbjct: 4   EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD------SKRDSLEEGELRDH- 56

Query: 187 SRSPPRPPRERFELGDGRKPVK-EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 245
                     R E+     P + E+ ME+R    D   I   ++ +   ++   +     
Sbjct: 57  ----------RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRK 106

Query: 246 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 293
           E+ +    +E+E      +   EE+++   E E     E A E S  E
Sbjct: 107 EKRKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 154



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 28/156 (17%), Positives = 62/156 (39%), Gaps = 18/156 (11%)

Query: 123 LEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 182
           L++ +R++E+E K   ++ +  + ++ +R + E  + R+ R E++  +   R + S + +
Sbjct: 17  LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR 76

Query: 183 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 242
                    +PP++           ++EK   R          D +RK     +   E  
Sbjct: 77  GEEDDSLAIKPPQQM---------SRKEKAHHR---------KDEKRKEKRKHARVKEKE 118

Query: 243 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE 278
              E  +   EE+++     E  +  E   E    E
Sbjct: 119 REHERRKRHREEQDKARREWERQKRREMAREHSRRE 154


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  234 bits (598), Expect = 2e-61
 Identities = 127/303 (41%), Positives = 185/303 (61%), Gaps = 3/303 (0%)

Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
           ++++  L RI EG +G+V++AK  +T EIVALK++ + + ++GFP  +LREI   L+   
Sbjct: 1   MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59

Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496
            N   V+   V  +     +   ++  DL  ++   ++P    +VK+ +  LL+GV   H
Sbjct: 60  DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTLWYRAPELLLGAK 555
            N I+HRDLK +NLL+S +G LK+ DFGLAR +     + YT  V T WYRAPELL GA+
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179

Query: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
           +Y   VD+WSVGCI GELL   PLFPGK++I+Q+  V + LGTP+ ++WP  +ELP   K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239

Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 675
           ++F E     L +     +S Q  DL+ +FL Y P +RI+A   L H+YF   PLP  PS
Sbjct: 240 ISFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPS 298

Query: 676 MFP 678
             P
Sbjct: 299 ELP 301


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  230 bits (587), Expect = 3e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 378 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 437
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173

Query: 438 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 497
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231

Query: 498 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 557
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291

Query: 558 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 616
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351

Query: 617 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 669
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  229 bits (583), Expect = 9e-60
 Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)

Query: 374 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 432
           CR+ ++++C+  I EG YG V++A+D K     VALKR++++  +EG P++++RE+  + 
Sbjct: 7   CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66

Query: 433 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 485
             +   HPN+V + ++   S  D   K+ +V  +V+ DL + ++ + +P +P E +K +M
Sbjct: 67  HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126

Query: 486 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 545
            QLLRG+  LH + ++HRDLK  N+L++ +G +K+ DFGLAR Y   + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185

Query: 546 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 605
           RAPE+LL +  Y+T VD+WSVGCIF E+  +KPLF G S++DQ+ K+   +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244

Query: 606 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 665
               LP     + S  P     ++F   + + G DL+ K LT+ P +RISA   L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300

Query: 666 RE 667
           ++
Sbjct: 301 QD 302


>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  229 bits (583), Expect = 9e-60
 Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)

Query: 374 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 432
           CR+ ++++C+  I EG YG V++A+D K     VALKR++++  +EG P++++RE+  + 
Sbjct: 7   CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66

Query: 433 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 485
             +   HPN+V + ++   S  D   K+ +V  +V+ DL + ++ + +P +P E +K +M
Sbjct: 67  HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126

Query: 486 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 545
            QLLRG+  LH + ++HRDLK  N+L++ +G +K+ DFGLAR Y   + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185

Query: 546 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 605
           RAPE+LL +  Y+T VD+WSVGCIF E+  +KPLF G S++DQ+ K+   +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244

Query: 606 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 665
               LP     + S  P     ++F   + + G DL+ K LT+ P +RISA   L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300

Query: 666 RE 667
           ++
Sbjct: 301 QD 302


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.129    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,012,079
Number of Sequences: 37866
Number of extensions: 1868776
Number of successful extensions: 139014
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2662
Number of HSP's successfully gapped in prelim test: 1508
Number of HSP's that attempted gapping in prelim test: 18286
Number of HSP's gapped (non-prelim): 34368
length of query: 737
length of database: 18,247,518
effective HSP length: 110
effective length of query: 627
effective length of database: 14,082,258
effective search space: 8829575766
effective search space used: 8829575766
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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