Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 16332362
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins)
isoform 4 [Homo sapiens]
(737 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 1476 0.0
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 1468 0.0
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 1467 0.0
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 1463 0.0
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 1461 0.0
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 1445 0.0
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 1441 0.0
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 1051 0.0
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 362 e-100
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens] 303 4e-82
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens] 290 3e-78
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens] 288 1e-77
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 271 1e-72
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 270 3e-72
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 254 2e-67
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 252 8e-67
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 248 1e-65
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 248 1e-65
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 246 7e-65
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 246 7e-65
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 241 2e-63
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 240 3e-63
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 240 4e-63
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 239 5e-63
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 239 5e-63
gi|169161522 PREDICTED: similar to cell division cycle 2-like 1 ... 235 1e-61
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 234 2e-61
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 230 3e-60
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 229 9e-60
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 229 9e-60
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 1476 bits (3821), Expect = 0.0
Identities = 737/737 (100%), Positives = 737/737 (100%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
Query: 61 EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 61 EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
Query: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 180
DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK
Sbjct: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 180
Query: 181 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 240
VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE
Sbjct: 181 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 240
Query: 241 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300
SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS
Sbjct: 241 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300
Query: 301 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 360
EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL
Sbjct: 301 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 360
Query: 361 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420
KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF
Sbjct: 361 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420
Query: 421 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 480
PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE
Sbjct: 421 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 480
Query: 481 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 540
VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV
Sbjct: 481 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 540
Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS
Sbjct: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL
Sbjct: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
Query: 661 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 720
KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT
Sbjct: 661 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 720
Query: 721 TTNQGASAAGPGFSLKF 737
TTNQGASAAGPGFSLKF
Sbjct: 721 TTNQGASAAGPGFSLKF 737
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 1468 bits (3801), Expect = 0.0
Identities = 733/737 (99%), Positives = 734/737 (99%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
+ SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35 LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
Query: 61 EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 95 EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 154
Query: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 180
DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK
Sbjct: 155 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDK 214
Query: 181 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 240
VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE
Sbjct: 215 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 274
Query: 241 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300
SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS
Sbjct: 275 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 334
Query: 301 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 360
EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL
Sbjct: 335 EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIEL 394
Query: 361 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 420
KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF
Sbjct: 395 KQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGF 454
Query: 421 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 480
PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE
Sbjct: 455 PITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE 514
Query: 481 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 540
VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV
Sbjct: 515 VKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVV 574
Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS
Sbjct: 575 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634
Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL
Sbjct: 635 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694
Query: 661 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 720
KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT
Sbjct: 695 KHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLT 754
Query: 721 TTNQGASAAGPGFSLKF 737
TTNQGASAAGPGFSLKF
Sbjct: 755 TTNQGASAAGPGFSLKF 771
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 1467 bits (3799), Expect = 0.0
Identities = 737/748 (98%), Positives = 737/748 (98%), Gaps = 11/748 (1%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
Query: 61 EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 109
EKVHHRKDEKRKEK KHARVKEKEREHERRKRHREEQDKARREWERQKRR
Sbjct: 61 EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 120
Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169
EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 121 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 180
Query: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 229
HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 240
Query: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 289
KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 241 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 300
Query: 290 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 349
SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 301 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 360
Query: 350 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 409
PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 361 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 420
Query: 410 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 469
RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 421 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 480
Query: 470 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 529
ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 481 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 540
Query: 530 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 589
GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI
Sbjct: 541 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 600
Query: 590 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 649
NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 601 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 660
Query: 650 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 709
PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 661 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 720
Query: 710 DDLKETGFHLTTTNQGASAAGPGFSLKF 737
DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 DDLKETGFHLTTTNQGASAAGPGFSLKF 748
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 1463 bits (3787), Expect = 0.0
Identities = 734/748 (98%), Positives = 735/748 (98%), Gaps = 11/748 (1%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
+ SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35 LKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
Query: 61 EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 109
EKVHHRKDEKRKEK KHARVKEKEREHERRKRHREEQDKARREWERQKRR
Sbjct: 95 EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 154
Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169
EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 155 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 214
Query: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 229
HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 215 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 274
Query: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 289
KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 275 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 334
Query: 290 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 349
SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 335 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 394
Query: 350 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 409
PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 395 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 454
Query: 410 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 469
RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 455 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 514
Query: 470 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 529
ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 515 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 574
Query: 530 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 589
GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI
Sbjct: 575 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 634
Query: 590 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 649
NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 635 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 694
Query: 650 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 709
PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 695 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 754
Query: 710 DDLKETGFHLTTTNQGASAAGPGFSLKF 737
DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 755 DDLKETGFHLTTTNQGASAAGPGFSLKF 782
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 1461 bits (3781), Expect = 0.0
Identities = 733/746 (98%), Positives = 734/746 (98%), Gaps = 9/746 (1%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
+ SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35 LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
Query: 61 EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 95 EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 154
Query: 121 ---------DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 171
DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR
Sbjct: 155 GNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 214
Query: 172 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 231
TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT
Sbjct: 215 TMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKT 274
Query: 232 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 291
SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA
Sbjct: 275 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 334
Query: 292 EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 351
EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD
Sbjct: 335 EEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 394
Query: 352 SPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL 411
SPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL
Sbjct: 395 SPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL 454
Query: 412 KMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMET 471
KMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMET
Sbjct: 455 KMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMET 514
Query: 472 MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGS 531
MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGS
Sbjct: 515 MKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGS 574
Query: 532 PLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINK 591
PLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINK
Sbjct: 575 PLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINK 634
Query: 592 VFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 651
VFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG
Sbjct: 635 VFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPG 694
Query: 652 RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDD 711
RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDD
Sbjct: 695 RRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDD 754
Query: 712 LKETGFHLTTTNQGASAAGPGFSLKF 737
LKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 755 LKETGFHLTTTNQGASAAGPGFSLKF 780
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 1445 bits (3741), Expect = 0.0
Identities = 726/738 (98%), Positives = 728/738 (98%), Gaps = 3/738 (0%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
+ SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35 LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
Query: 61 EKVHHRKDEKRKEK-KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 119
EKVHHRKDEKRKEK KHARVKE REHERRKRHREEQDKARREWERQKRREMAREHSRRE
Sbjct: 95 EKVHHRKDEKRKEKWKHARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRE 152
Query: 120 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 179
RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD
Sbjct: 153 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 212
Query: 180 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 239
KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA
Sbjct: 213 KVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 272
Query: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM
Sbjct: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332
Query: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIE 359
SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIE
Sbjct: 333 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 392
Query: 360 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 419
LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG
Sbjct: 393 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 452
Query: 420 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 479
FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG
Sbjct: 453 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512
Query: 480 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 539
EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV
Sbjct: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 572
Query: 540 VVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP 599
VVT WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTP
Sbjct: 573 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 632
Query: 600 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 659
SEKIWPGYSELP VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG
Sbjct: 633 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 692
Query: 660 LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL 719
LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL
Sbjct: 693 LKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHL 752
Query: 720 TTTNQGASAAGPGFSLKF 737
TTTNQGASAAGPGFSLKF
Sbjct: 753 TTTNQGASAAGPGFSLKF 770
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 1441 bits (3731), Expect = 0.0
Identities = 726/748 (97%), Positives = 728/748 (97%), Gaps = 13/748 (1%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
+ SDDRDSKRDSLEEGELRDH MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35 LKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
Query: 61 EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 109
EKVHHRKDEKRKEK KHARVKE REHERRKRHREEQDKARREWERQKRR
Sbjct: 95 EKVHHRKDEKRKEKCRHHSHSAEGGKHARVKE--REHERRKRHREEQDKARREWERQKRR 152
Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169
EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 153 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 212
Query: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 229
HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 213 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 272
Query: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 289
KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 273 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 332
Query: 290 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 349
SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 333 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 392
Query: 350 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 409
PDSPAL PIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 393 PDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 452
Query: 410 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 469
RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 453 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 512
Query: 470 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 529
ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 513 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 572
Query: 530 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 589
GSPLKAYTPVVVT WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQI
Sbjct: 573 GSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQI 632
Query: 590 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 649
NKVFK+LGTPSEKIWPGYSELP VKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 633 NKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 692
Query: 650 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 709
PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 693 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 752
Query: 710 DDLKETGFHLTTTNQGASAAGPGFSLKF 737
DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 753 DDLKETGFHLTTTNQGASAAGPGFSLKF 780
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 1051 bits (2719), Expect = 0.0
Identities = 526/526 (100%), Positives = 526/526 (100%)
Query: 212 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 271
MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 1 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
Query: 272 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 331
EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 61 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
Query: 332 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 391
EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180
Query: 392 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 451
GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240
Query: 452 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 511
DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300
Query: 512 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 571
LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360
Query: 572 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 631
ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420
Query: 632 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 691
ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480
Query: 692 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 737
GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526
Score = 35.8 bits (81), Expect = 0.15
Identities = 39/192 (20%), Positives = 67/192 (34%), Gaps = 24/192 (12%)
Query: 57 MSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS 116
M ++ + +D E+K + + E EE+++ E E S
Sbjct: 1 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE-----------EGS 49
Query: 117 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED 176
E E E + E+++E+ E A E+ E + E+S E+
Sbjct: 50 TSE-----------ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 98
Query: 177 YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAES 236
+ V S + R E+G+G + + E D + D +S E K +
Sbjct: 99 HLLVVPESRFDRDSGESEEAEEEVGEGTP--QSSALTEGDYVPDSPALSPIELKQELPKY 156
Query: 237 SSAESGSGSEEE 248
A G S EE
Sbjct: 157 LPALQGCRSVEE 168
Score = 31.2 bits (69), Expect = 3.6
Identities = 28/122 (22%), Positives = 48/122 (39%), Gaps = 8/122 (6%)
Query: 37 DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQ 96
D + D + DS + S E ++E+ +E++ E+E + EE+
Sbjct: 5 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE-----EEEEGSTSEESEEEEE 59
Query: 97 DKARREWERQKRREMAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRA 153
++ E E E A E S E + E ER+ E + + + R+ E E
Sbjct: 60 EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAE 119
Query: 154 EE 155
EE
Sbjct: 120 EE 121
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 362 bits (928), Expect = e-100
Identities = 176/327 (53%), Positives = 240/327 (73%), Gaps = 6/327 (1%)
Query: 374 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 433
CRSV+EF+ LNRI EGTYG+VYRA+D +TDEIVALK+++M+KEK+G PI+SLREI +L+
Sbjct: 33 CRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLR 92
Query: 434 AQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVK 493
+HPNIV ++E+VVG++++ I++VM Y E DL SL+E M PF +VK +++Q+LRG++
Sbjct: 93 LRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQ 152
Query: 494 HLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLG 553
+LH N+I+HRDLK SNLL++ G +K DFGLAR YG P+K TP VVTLWYRAPELLLG
Sbjct: 153 YLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLG 212
Query: 554 AKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAV 613
+T++DMW+VGCI ELL +PL PG SEI QI+ + + LGTPSE IWPG+S+LP V
Sbjct: 213 TTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLV 272
Query: 614 KKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPID 673
+ + + PYNNL+ +F LS+ G L++ Y P +R +A D L+ YF+E PLP +
Sbjct: 273 GQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 331
Query: 674 PSMFPTWPAKSEQQRVKRGTSPRPPEG 700
P + PT+P R KR +P EG
Sbjct: 332 PELMPTFP----HHRNKR-AAPATSEG 353
>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
Length = 289
Score = 303 bits (776), Expect = 4e-82
Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)
Query: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
Query: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
Query: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
Query: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
Query: 653 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 700
R +A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282
>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
Length = 283
Score = 290 bits (743), Expect = 3e-78
Identities = 145/288 (50%), Positives = 200/288 (69%), Gaps = 12/288 (4%)
Query: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
Query: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
Query: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
Query: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLF------ 233
Query: 653 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 700
+A D L+ YF+E PLP +P + PT+P R KR +P EG
Sbjct: 234 MATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 276
>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
Length = 272
Score = 288 bits (738), Expect = 1e-77
Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)
Query: 413 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 472
M+KEK+G PI+SLREI +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60
Query: 473 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 532
PF +VK +++Q+LRG+++LH N+I+HRDLK SNLL++ G +K DFGLAR YG P
Sbjct: 61 PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120
Query: 533 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 592
+K TP VVTLWYRAPELLLG +T++DMW+VGCI ELL +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180
Query: 593 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 652
+ LGTPSE IWPG+S+LP V + + + PYNNL+ +F LS+ G L++ Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239
Query: 653 RISAEDGLKHEYFRETPL 670
R +A D L+ YF+E PL
Sbjct: 240 RATAGDCLESSYFKEKPL 257
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 271 bits (694), Expect = 1e-72
Identities = 136/290 (46%), Positives = 202/290 (69%), Gaps = 5/290 (1%)
Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
++ FQ + +I EGTYGVVY+AK+++T ++VALK+++++ E EG P T++REI+ + + +H
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 495
PNIV + ++V N K+Y+V ++ DLK M++ LP +K+ + QLL+GV
Sbjct: 61 PNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFC 118
Query: 496 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 555
H + ++HRDLK NLL++ G +K+ DFGLAR +G PL+ YT VVTLWYRAPE+LLG+K
Sbjct: 119 HSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSK 178
Query: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
Y+TAVD+WS+GCIF E++T+K LFPG SEIDQ+ ++F+ LGTPSE WPG ++LP K
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG 238
Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 665
+F + L + L +G DL+ + L Y P +RI+A+ L H YF
Sbjct: 239 -SFPKWTRKGL-EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 270 bits (691), Expect = 3e-72
Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)
Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
+E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + + H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 495
PNIV + +++ N K+Y+V ++ DLK M+ +P +K+ + QLL+G+
Sbjct: 61 PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
Query: 496 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 555
H + +LHRDLK NLL++ G +K+ DFGLAR +G P++ YT VVTLWYRAPE+LLG K
Sbjct: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
Query: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P K
Sbjct: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 672
+F + + K L + G L+++ L Y P +RISA+ L H +F++ P+
Sbjct: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 254 bits (649), Expect = 2e-67
Identities = 124/297 (41%), Positives = 197/297 (66%), Gaps = 14/297 (4%)
Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
+E++ + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 490
PNIV+++++++ + ++Y++ ++ DLK ++++ PG+ VK+ + Q+L+
Sbjct: 61 PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114
Query: 491 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 550
G+ H +LHRDLK NLL+ G +K+ DFGLAR +G P++ YT VVTLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174
Query: 551 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 610
LLG+ YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234
Query: 611 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 667
K TF + +L L + G DL++K L Y P +RIS + L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 252 bits (644), Expect = 8e-67
Identities = 122/297 (41%), Positives = 196/297 (65%), Gaps = 14/297 (4%)
Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
+E++ + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 490
PNIV+++++++ + ++Y++ ++ DLK ++++ PG+ VK+ + Q+L+
Sbjct: 61 PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114
Query: 491 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 550
G+ H +LHRDLK NLL+ G +K+ DFGLAR +G P++ YT +TLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEV 174
Query: 551 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 610
LLG+ YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234
Query: 611 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 667
K TF + +L L + G DL++K L Y P +RIS + L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 248 bits (633), Expect = 1e-65
Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)
Query: 29 RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 86
R+ Y R S E G+ S P S R+ + + +R K +R R
Sbjct: 366 RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
Query: 87 ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 142
R RHR + ++R + +A E ++ ++ R + R E + +
Sbjct: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
Query: 143 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 202
+ K + + SA +D K+K H + SP + +
Sbjct: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538
Query: 203 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262
+ P++ K+E ++ ++ T A ES S + +EE +E+ + T
Sbjct: 539 TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589
Query: 263 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 322
+E+E+ T + E+ D R N + V
Sbjct: 590 SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634
Query: 323 SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 372
E E+ + P L GD + SP + + K+ P+Y +
Sbjct: 635 KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694
Query: 373 ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
G R V++F + I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI
Sbjct: 695 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754
Query: 430 TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
+ + H +I+ ++EIV DK Y+V Y++HDL L+E+ F +
Sbjct: 755 ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
Query: 482 KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFGLAR Y S + YT V
Sbjct: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + + G+P
Sbjct: 875 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
+WP +LP M + LR+ F + DL + L P +R +AE L
Sbjct: 935 PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993
Query: 661 KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 691
+ E+ R+ P + P P W E KR
Sbjct: 994 QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
Score = 35.4 bits (80), Expect = 0.19
Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)
Query: 59 RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 114
R+ + R+ + + R KE+ REH RR R + ++R ++R E+A+
Sbjct: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
Query: 115 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 167
S RR+ ++R + + + KE +E K RE + E
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
Query: 168 AHHRTM-------RED--YSDKVKASHWSRSPPRP 193
A+ R R+D S + S SR P P
Sbjct: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
Score = 33.5 bits (75), Expect = 0.73
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 106 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 159
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Query: 160 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 204
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
Query: 205 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 264
+P + L D S R + S S + S +G GS+
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
Query: 265 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 324
+ S S +S + +VS S R + + P S R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
Query: 325 ES 326
+S
Sbjct: 408 KS 409
Score = 30.4 bits (67), Expect = 6.2
Identities = 47/246 (19%), Positives = 75/246 (30%), Gaps = 20/246 (8%)
Query: 77 ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 136
+R + H R + +E A +E + R + + R R L L + +
Sbjct: 270 SRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSH 329
Query: 137 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS-------------DKVKA 183
R Q + + R R S + R YS +
Sbjct: 330 RASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389
Query: 184 SHW--SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 241
S W SRSP P R R P R +S S + SS S+
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSR----SRHRLSRSRSRHSSISPSTLTL 445
Query: 242 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 301
S S E + ++ + +E + E + E + + +AS S E S
Sbjct: 446 KS-SLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSA 504
Query: 302 DEEREN 307
+ N
Sbjct: 505 SASQTN 510
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 248 bits (633), Expect = 1e-65
Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)
Query: 29 RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 86
R+ Y R S E G+ S P S R+ + + +R K +R R
Sbjct: 366 RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
Query: 87 ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 142
R RHR + ++R + +A E ++ ++ R + R E + +
Sbjct: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
Query: 143 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 202
+ K + + SA +D K+K H + SP + +
Sbjct: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538
Query: 203 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262
+ P++ K+E ++ ++ T A ES S + +EE +E+ + T
Sbjct: 539 TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589
Query: 263 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 322
+E+E+ T + E+ D R N + V
Sbjct: 590 SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634
Query: 323 SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 372
E E+ + P L GD + SP + + K+ P+Y +
Sbjct: 635 KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694
Query: 373 ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
G R V++F + I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI
Sbjct: 695 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754
Query: 430 TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
+ + H +I+ ++EIV DK Y+V Y++HDL L+E+ F +
Sbjct: 755 ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
Query: 482 KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFGLAR Y S + YT V
Sbjct: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + + G+P
Sbjct: 875 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
+WP +LP M + LR+ F + DL + L P +R +AE L
Sbjct: 935 PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993
Query: 661 KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 691
+ E+ R+ P + P P W E KR
Sbjct: 994 QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
Score = 35.4 bits (80), Expect = 0.19
Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)
Query: 59 RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 114
R+ + R+ + + R KE+ REH RR R + ++R ++R E+A+
Sbjct: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
Query: 115 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 167
S RR+ ++R + + + KE +E K RE + E
Sbjct: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
Query: 168 AHHRTM-------RED--YSDKVKASHWSRSPPRP 193
A+ R R+D S + S SR P P
Sbjct: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
Score = 33.5 bits (75), Expect = 0.73
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 106 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 159
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Query: 160 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 204
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
Query: 205 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 264
+P + L D S R + S S + S +G GS+
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
Query: 265 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 324
+ S S +S + +VS S R + + P S R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
Query: 325 ES 326
+S
Sbjct: 408 KS 409
Score = 30.4 bits (67), Expect = 6.2
Identities = 47/246 (19%), Positives = 75/246 (30%), Gaps = 20/246 (8%)
Query: 77 ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 136
+R + H R + +E A +E + R + + R R L L + +
Sbjct: 270 SRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSH 329
Query: 137 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS-------------DKVKA 183
R Q + + R R S + R YS +
Sbjct: 330 RASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389
Query: 184 SHW--SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 241
S W SRSP P R R P R +S S + SS S+
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSR----SRHRLSRSRSRHSSISPSTLTL 445
Query: 242 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 301
S S E + ++ + +E + E + E + + +AS S E S
Sbjct: 446 KS-SLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSA 504
Query: 302 DEEREN 307
+ N
Sbjct: 505 SASQTN 510
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 246 bits (627), Expect = 7e-65
Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)
Query: 325 ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 371
E E+ + P L GD P DSP I Q+ K P +
Sbjct: 657 EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716
Query: 372 --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
G R V++F + I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI
Sbjct: 717 SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776
Query: 430 TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
+ + H ++V ++EIV DK Y+V Y++HDL L+E+ F +
Sbjct: 777 ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836
Query: 482 KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
K+ M QL+ G+++ H LHRD+K SN+LL+++G +K+ DFGLAR Y S + YT V
Sbjct: 837 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896
Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + + G+P
Sbjct: 897 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956
Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
+WP +LP M + LR+ F + + DL++ LT P +R +AE L
Sbjct: 957 PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015
Query: 661 KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 693
+ ++ ++ L + P P W P+K+ ++ GT
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075
Query: 694 -------SPRPPEGGLGYSQLGDDD 711
SP PP+ G + G D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100
Score = 39.7 bits (91), Expect = 0.010
Identities = 44/200 (22%), Positives = 79/200 (39%), Gaps = 18/200 (9%)
Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQRE-----QKERERRAEERRKEREARR 164
+MA + RRE D +R + Q + R+ Q E+E+ E K +
Sbjct: 86 DMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145
Query: 165 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 224
+S + E+ D KA ++S + R K KE+ +ER+L S +D
Sbjct: 146 RISGSSKRSNEETDDYGKA-QVAKSSSKESR-------SSKLHKEKTRKERELKSGHKDR 197
Query: 225 SDSERKTSSAES----SSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 280
S S RK + +S S + S S + + ++++ S S S ++ + T
Sbjct: 198 SKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDD-SPSGASYGQDYDLSPSRSHTS 256
Query: 281 SNSEEASEQSAEEVSEEEMS 300
SN + + + +S
Sbjct: 257 SNYDSYKKSPGSTSRRQSVS 276
Score = 39.3 bits (90), Expect = 0.013
Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 35 REDSMEDRGEEDDSLAIKPPQQMSRKE----KVHHRKDEKRKEKKHARVKEKEREHERRK 90
R ++ E RG + K R+ K + EK +E K+R K
Sbjct: 93 RRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSK 152
Query: 91 RHREEQDK------ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 144
R EE D A+ + + ++ +E +R+ER+ L+ + R + + RE K +
Sbjct: 153 RSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE-LKSGHKDRSKSHRKRETPKSYK 211
Query: 145 --EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR---SPPRPPRERFE 199
+ +R R+ R+ ++++ S + +DY SH S S + P
Sbjct: 212 TVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSR 271
Query: 200 LGDGRKPVKEEKMEERDLLSD------LQDISD-SERKTSSAESSSAESG 242
P KE + S + +S S R++SS E S + SG
Sbjct: 272 RQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG 321
Score = 38.1 bits (87), Expect = 0.030
Identities = 83/394 (21%), Positives = 130/394 (32%), Gaps = 65/394 (16%)
Query: 35 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKERE-----HERR 89
+ SM+DR + + + + E R K H KERE +R
Sbjct: 139 KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRS 198
Query: 90 KRHRE-EQDKARREWERQKRREMAREHSRRERDRLEQ--------------LERKRERER 134
K HR+ E K+ + + KRR +R R+ D +Q L R
Sbjct: 199 KSHRKRETPKSYKTVDSPKRR--SRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTS 256
Query: 135 KMREQQKEQREQKERERRAEERRKEREA------------RREVSAHHRTMREDYSDKVK 182
+ K+ R + KE A RR+ S + R S +
Sbjct: 257 SNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316
Query: 183 ASHWSRSPPRPPRER------FELGDGRKPV---KEEKMEERDLLSDLQDISDSERKTSS 233
S+ RSP R R + R P+ K K R S S++K SS
Sbjct: 317 GSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSS 376
Query: 234 AESSSA---------ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE-----EEEEEEET 279
+ S + S G+E +++E + + +E + +E
Sbjct: 377 SRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVE 436
Query: 280 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE------V 333
+S S++ V E+ + D E N HL ++ D + +E E+
Sbjct: 437 AKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLK 496
Query: 334 GEGTPQSS--ALTEGDYVPDSPALSPIELKQELP 365
+GT S AL E P S E LP
Sbjct: 497 AQGTRDSKPIALKEEIVTPKETETSEKETPPPLP 530
Score = 37.7 bits (86), Expect = 0.039
Identities = 48/223 (21%), Positives = 83/223 (37%), Gaps = 26/223 (11%)
Query: 90 KRHREEQDKARREWERQKRREMAREHS-RRERDRLEQLERKRERERKMREQ--------- 139
K R E D+ RR +R R R H RR RD L+ + ++E+ +++ +
Sbjct: 90 KLDRRENDE-RRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRIS 148
Query: 140 --QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 197
K E+ + +A+ + + R H R++ ++K+ H RS RE
Sbjct: 149 GSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKE--RELKSGHKDRSKSHRKRET 206
Query: 198 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE-----SGSGSEEEEEEE 252
K K +R S + SDS ++ S +S S S S +
Sbjct: 207 ------PKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYD 260
Query: 253 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 295
++ GSTS +E ++ + S + VS
Sbjct: 261 SYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVS 303
Score = 34.7 bits (78), Expect = 0.33
Identities = 38/231 (16%), Positives = 89/231 (38%), Gaps = 12/231 (5%)
Query: 41 DRGEEDDSLAIKPPQQMSRKEKVH-HRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA 99
DR E D+ + R +++H HR + R+ + + K+ E+E + + K
Sbjct: 92 DRRENDER------RGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145
Query: 100 RREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE 159
R ++ E ++ + + + E + + K + +++ + + ++R R++E
Sbjct: 146 RISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRE 205
Query: 160 R-EARREVSAHHRTMREDYSDKVKASHWSRSPPRPP-RERFELGDGRKPVK---EEKMEE 214
++ + V + R R + +S SP + ++L R + +
Sbjct: 206 TPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKS 265
Query: 215 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 265
S Q +S ++ S+ +SS+ S + S+ E S
Sbjct: 266 PGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 246 bits (627), Expect = 7e-65
Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)
Query: 325 ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 371
E E+ + P L GD P DSP I Q+ K P +
Sbjct: 657 EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716
Query: 372 --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
G R V++F + I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI
Sbjct: 717 SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776
Query: 430 TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
+ + H ++V ++EIV DK Y+V Y++HDL L+E+ F +
Sbjct: 777 ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836
Query: 482 KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
K+ M QL+ G+++ H LHRD+K SN+LL+++G +K+ DFGLAR Y S + YT V
Sbjct: 837 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896
Query: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + + G+P
Sbjct: 897 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956
Query: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
+WP +LP M + LR+ F + + DL++ LT P +R +AE L
Sbjct: 957 PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015
Query: 661 KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 693
+ ++ ++ L + P P W P+K+ ++ GT
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075
Query: 694 -------SPRPPEGGLGYSQLGDDD 711
SP PP+ G + G D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100
Score = 39.7 bits (91), Expect = 0.010
Identities = 44/200 (22%), Positives = 79/200 (39%), Gaps = 18/200 (9%)
Query: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQRE-----QKERERRAEERRKEREARR 164
+MA + RRE D +R + Q + R+ Q E+E+ E K +
Sbjct: 86 DMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145
Query: 165 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 224
+S + E+ D KA ++S + R K KE+ +ER+L S +D
Sbjct: 146 RISGSSKRSNEETDDYGKA-QVAKSSSKESR-------SSKLHKEKTRKERELKSGHKDR 197
Query: 225 SDSERKTSSAES----SSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 280
S S RK + +S S + S S + + ++++ S S S ++ + T
Sbjct: 198 SKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDD-SPSGASYGQDYDLSPSRSHTS 256
Query: 281 SNSEEASEQSAEEVSEEEMS 300
SN + + + +S
Sbjct: 257 SNYDSYKKSPGSTSRRQSVS 276
Score = 39.3 bits (90), Expect = 0.013
Identities = 51/230 (22%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 35 REDSMEDRGEEDDSLAIKPPQQMSRKE----KVHHRKDEKRKEKKHARVKEKEREHERRK 90
R ++ E RG + K R+ K + EK +E K+R K
Sbjct: 93 RRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSK 152
Query: 91 RHREEQDK------ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 144
R EE D A+ + + ++ +E +R+ER+ L+ + R + + RE K +
Sbjct: 153 RSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE-LKSGHKDRSKSHRKRETPKSYK 211
Query: 145 --EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR---SPPRPPRERFE 199
+ +R R+ R+ ++++ S + +DY SH S S + P
Sbjct: 212 TVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSR 271
Query: 200 LGDGRKPVKEEKMEERDLLSD------LQDISD-SERKTSSAESSSAESG 242
P KE + S + +S S R++SS E S + SG
Sbjct: 272 RQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSG 321
Score = 38.1 bits (87), Expect = 0.030
Identities = 83/394 (21%), Positives = 130/394 (32%), Gaps = 65/394 (16%)
Query: 35 REDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKERE-----HERR 89
+ SM+DR + + + + E R K H KERE +R
Sbjct: 139 KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRS 198
Query: 90 KRHRE-EQDKARREWERQKRREMAREHSRRERDRLEQ--------------LERKRERER 134
K HR+ E K+ + + KRR +R R+ D +Q L R
Sbjct: 199 KSHRKRETPKSYKTVDSPKRR--SRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTS 256
Query: 135 KMREQQKEQREQKERERRAEERRKEREA------------RREVSAHHRTMREDYSDKVK 182
+ K+ R + KE A RR+ S + R S +
Sbjct: 257 SNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316
Query: 183 ASHWSRSPPRPPRER------FELGDGRKPV---KEEKMEERDLLSDLQDISDSERKTSS 233
S+ RSP R R + R P+ K K R S S++K SS
Sbjct: 317 GSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSS 376
Query: 234 AESSSA---------ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE-----EEEEEEET 279
+ S + S G+E +++E + + +E + +E
Sbjct: 377 SRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVE 436
Query: 280 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE------V 333
+S S++ V E+ + D E N HL ++ D + +E E+
Sbjct: 437 AKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLK 496
Query: 334 GEGTPQSS--ALTEGDYVPDSPALSPIELKQELP 365
+GT S AL E P S E LP
Sbjct: 497 AQGTRDSKPIALKEEIVTPKETETSEKETPPPLP 530
Score = 37.7 bits (86), Expect = 0.039
Identities = 48/223 (21%), Positives = 83/223 (37%), Gaps = 26/223 (11%)
Query: 90 KRHREEQDKARREWERQKRREMAREHS-RRERDRLEQLERKRERERKMREQ--------- 139
K R E D+ RR +R R R H RR RD L+ + ++E+ +++ +
Sbjct: 90 KLDRRENDE-RRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRIS 148
Query: 140 --QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 197
K E+ + +A+ + + R H R++ ++K+ H RS RE
Sbjct: 149 GSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKE--RELKSGHKDRSKSHRKRET 206
Query: 198 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE-----SGSGSEEEEEEE 252
K K +R S + SDS ++ S +S S S S +
Sbjct: 207 ------PKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYD 260
Query: 253 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 295
++ GSTS +E ++ + S + VS
Sbjct: 261 SYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVS 303
Score = 34.7 bits (78), Expect = 0.33
Identities = 38/231 (16%), Positives = 89/231 (38%), Gaps = 12/231 (5%)
Query: 41 DRGEEDDSLAIKPPQQMSRKEKVH-HRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA 99
DR E D+ + R +++H HR + R+ + + K+ E+E + + K
Sbjct: 92 DRRENDER------RGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKD 145
Query: 100 RREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE 159
R ++ E ++ + + + E + + K + +++ + + ++R R++E
Sbjct: 146 RISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRE 205
Query: 160 R-EARREVSAHHRTMREDYSDKVKASHWSRSPPRPP-RERFELGDGRKPVK---EEKMEE 214
++ + V + R R + +S SP + ++L R + +
Sbjct: 206 TPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKS 265
Query: 215 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEES 265
S Q +S ++ S+ +SS+ S + S+ E S
Sbjct: 266 PGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERS 316
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 241 bits (614), Expect = 2e-63
Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)
Query: 373 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 432
G +E + L ++ EGTY VY+ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243
Query: 433 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 491
+H NIVT+ +IV + DK + +V Y++ DLK M+ VK + Q+LRG
Sbjct: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
Query: 492 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 551
+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
Query: 552 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 611
LG+ EYST +DMW VGCIF E+ + +PLFPG + D+++ +F+ LGTPS++ WPG S
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
Query: 612 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 666
K F ++ L L +G +L+ KFL Y +R+SAE+ +KH YFR
Sbjct: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 240 bits (613), Expect = 3e-63
Identities = 130/336 (38%), Positives = 198/336 (58%), Gaps = 16/336 (4%)
Query: 378 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKM---EKEKEGFPITSLREINTILKA 434
+ ++ L+ + EG + VY+A+DK T++IVA+K++K+ + K+G T+LREI + +
Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69
Query: 435 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKH 494
HPNI+ + + + I +V +++E DL+ +++ P +K M+ L+G+++
Sbjct: 70 SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127
Query: 495 LHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGA 554
LH +WILHRDLK +NLLL G+LK+ DFGLA+ +GSP +AYT VVT WYRAPELL GA
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187
Query: 555 KEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVK 614
+ Y VDMW+VGCI ELL + P PG S++DQ+ ++F+ LGTP+E+ WP LP
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP--D 245
Query: 615 KMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDP 674
+TF P L F A D DL+ + P RI+A LK +YF P P
Sbjct: 246 YVTFKSFPGIPLHHIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304
Query: 675 SMF--PTWPAKSEQQR------VKRGTSPRPPEGGL 702
P P ++ +++ +KR + +GGL
Sbjct: 305 CQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL 340
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 240 bits (612), Expect = 4e-63
Identities = 122/292 (41%), Positives = 186/292 (63%), Gaps = 5/292 (1%)
Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
+++++ L +I EGTYG V++AK+++T EIVALKR++++ + EG P ++LREI + + +H
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496
NIV + +++ K+ +V + + DLK ++ P VK+ + QLL+G+ H
Sbjct: 61 KNIVRLHDVLHSDK--KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118
Query: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 556
+LHRDLK NLL++ G LK+ DFGLAR +G P++ Y+ VVTLWYR P++L GAK
Sbjct: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178
Query: 557 YSTAVDMWSVGCIFGELLTQ-KPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
YST++DMWS GCIF EL +PLFPG DQ+ ++F+ LGTP+E+ WP ++LP K
Sbjct: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237
Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 667
+ +P L+ G DL+ L P +RISAE+ L+H YF +
Sbjct: 238 -PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 239 bits (611), Expect = 5e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 41 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
Query: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 358
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147
Query: 359 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 416
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207
Query: 417 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 476
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264
Query: 477 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 536
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324
Query: 537 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 596
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384
Query: 597 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 656
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443
Query: 657 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 694
ED +KH +F R LP S+F + +++ R +S
Sbjct: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 239 bits (611), Expect = 5e-63
Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)
Query: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
ESG G + E G E E+ S+ S+Q++ S+E
Sbjct: 35 ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94
Query: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 358
S R NH P + +E+ + + P L EG Y+ SPI
Sbjct: 95 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141
Query: 359 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 416
L + L + + G +E + L+++ EGTY VY+ K K TD +VALK +++E E
Sbjct: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201
Query: 417 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 476
EG P T++RE++ + +H NIVT+ +I+ + +V Y++ DLK ++
Sbjct: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258
Query: 477 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 536
VK + QLLRG+ + H +LHRDLK NLL++ G LK+ DFGLAR P K Y
Sbjct: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318
Query: 537 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 596
+ VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG + +Q++ +F+ L
Sbjct: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378
Query: 597 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 656
GTP+E+ WPG K + ++ L L SD G DL+ K L + RISA
Sbjct: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437
Query: 657 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 694
ED +KH +F R LP S+F + +++ R +S
Sbjct: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480
>gi|169161522 PREDICTED: similar to cell division cycle 2-like 1
(PITSLRE proteins) [Homo sapiens]
Length = 155
Score = 235 bits (600), Expect = 1e-61
Identities = 116/121 (95%), Positives = 117/121 (96%), Gaps = 1/121 (0%)
Query: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
+ SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 35 LKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
Query: 61 EKVHHRKDEKRKEK-KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 119
EK HHRKDEKRKEK KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE
Sbjct: 95 EKAHHRKDEKRKEKRKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 154
Query: 120 R 120
R
Sbjct: 155 R 155
Score = 35.4 bits (80), Expect = 0.19
Identities = 33/168 (19%), Positives = 67/168 (39%), Gaps = 18/168 (10%)
Query: 127 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 186
E+ + + + E +E++ +KE+E +AE +R + R+ + R+ + H
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD------SKRDSLEEGELRDH- 56
Query: 187 SRSPPRPPRERFELGDGRKPVK-EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 245
R E+ P + E+ ME+R D I ++ + ++ +
Sbjct: 57 ----------RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRK 106
Query: 246 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 293
E+ + +E+E + EE+++ E E E A E S E
Sbjct: 107 EKRKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 154
Score = 35.0 bits (79), Expect = 0.25
Identities = 28/156 (17%), Positives = 62/156 (39%), Gaps = 18/156 (11%)
Query: 123 LEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 182
L++ +R++E+E K ++ + + ++ +R + E + R+ R E++ + R + S + +
Sbjct: 17 LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR 76
Query: 183 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 242
+PP++ ++EK R D +RK + E
Sbjct: 77 GEEDDSLAIKPPQQM---------SRKEKAHHR---------KDEKRKEKRKHARVKEKE 118
Query: 243 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE 278
E + EE+++ E + E E E
Sbjct: 119 REHERRKRHREEQDKARREWERQKRREMAREHSRRE 154
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 234 bits (598), Expect = 2e-61
Identities = 127/303 (41%), Positives = 185/303 (61%), Gaps = 3/303 (0%)
Query: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436
++++ L RI EG +G+V++AK +T EIVALK++ + + ++GFP +LREI L+
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59
Query: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496
N V+ V + + ++ DL ++ ++P +VK+ + LL+GV H
Sbjct: 60 DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119
Query: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTLWYRAPELLLGAK 555
N I+HRDLK +NLL+S +G LK+ DFGLAR + + YT V T WYRAPELL GA+
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179
Query: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615
+Y VD+WSVGCI GELL PLFPGK++I+Q+ V + LGTP+ ++WP +ELP K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239
Query: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 675
++F E L + +S Q DL+ +FL Y P +RI+A L H+YF PLP PS
Sbjct: 240 ISFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPS 298
Query: 676 MFP 678
P
Sbjct: 299 ELP 301
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 230 bits (587), Expect = 3e-60
Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)
Query: 378 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 437
+ ++ L ++ EG+Y VY+ K K ++VALK +++++E EG P T++RE + + +H
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173
Query: 438 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 497
NIV + +I+ + + +V YV DL M+ P VK + QLLRG+ ++H
Sbjct: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231
Query: 498 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 557
+ILHRDLK NLL+S G LK+ DFGLAR P Y+ VVTLWYR P++LLG+ EY
Sbjct: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291
Query: 558 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 616
ST +DMW VGCIF E++ FPG +I DQ+ ++F LGTP+E WPG LP K
Sbjct: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351
Query: 617 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 669
F+ + NLR+ + L + DL +K L P R+SA+ L HEYF + P
Sbjct: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 229 bits (583), Expect = 9e-60
Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)
Query: 374 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 432
CR+ ++++C+ I EG YG V++A+D K VALKR++++ +EG P++++RE+ +
Sbjct: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66
Query: 433 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 485
+ HPN+V + ++ S D K+ +V +V+ DL + ++ + +P +P E +K +M
Sbjct: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126
Query: 486 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 545
QLLRG+ LH + ++HRDLK N+L++ +G +K+ DFGLAR Y + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185
Query: 546 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 605
RAPE+LL + Y+T VD+WSVGCIF E+ +KPLF G S++DQ+ K+ +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244
Query: 606 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 665
LP + S P ++F + + G DL+ K LT+ P +RISA L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300
Query: 666 RE 667
++
Sbjct: 301 QD 302
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 229 bits (583), Expect = 9e-60
Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)
Query: 374 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 432
CR+ ++++C+ I EG YG V++A+D K VALKR++++ +EG P++++RE+ +
Sbjct: 7 CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66
Query: 433 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 485
+ HPN+V + ++ S D K+ +V +V+ DL + ++ + +P +P E +K +M
Sbjct: 67 HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126
Query: 486 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 545
QLLRG+ LH + ++HRDLK N+L++ +G +K+ DFGLAR Y + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185
Query: 546 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 605
RAPE+LL + Y+T VD+WSVGCIF E+ +KPLF G S++DQ+ K+ +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244
Query: 606 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 665
LP + S P ++F + + G DL+ K LT+ P +RISA L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300
Query: 666 RE 667
++
Sbjct: 301 QD 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.129 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,012,079
Number of Sequences: 37866
Number of extensions: 1868776
Number of successful extensions: 139014
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2662
Number of HSP's successfully gapped in prelim test: 1508
Number of HSP's that attempted gapping in prelim test: 18286
Number of HSP's gapped (non-prelim): 34368
length of query: 737
length of database: 18,247,518
effective HSP length: 110
effective length of query: 627
effective length of database: 14,082,258
effective search space: 8829575766
effective search space used: 8829575766
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.