Search of human proteins with 15991829

Search of human proteins with 15991829

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
         (921 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1836   0.0  
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]            1836   0.0  
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]                 1788   0.0  
gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]                1788   0.0  
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]              1788   0.0  
gi|15553127 hexokinase 2 [Homo sapiens]                              1369   0.0  
gi|156151420 hexokinase domain containing 1 [Homo sapiens]           1323   0.0  
gi|194097330 hexokinase 3 [Homo sapiens]                              944   0.0  
gi|15967161 glucokinase isoform 3 [Homo sapiens]                      506   e-143
gi|4503951 glucokinase isoform 1 [Homo sapiens]                       504   e-142
gi|15967159 glucokinase isoform 2 [Homo sapiens]                      503   e-142
gi|164663810 ribosomal modification protein rimK-like family mem...    35   0.42 
gi|134254462 ribosomal modification protein rimK-like family mem...    33   0.93 
gi|21389509 KPL2 protein isoform 2 [Homo sapiens]                      32   2.7  
gi|145699133 KPL2 protein isoform 1 [Homo sapiens]                     32   2.7  
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof...    32   3.5  
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...    32   3.5  
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    32   3.5  
gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens]        30   7.9  

>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1836 bits (4756), Expect = 0.0
 Identities = 921/921 (100%), Positives = 921/921 (100%)

Query: 1   MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN 60
           MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN
Sbjct: 1   MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN 60

Query: 61  PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE 120
           PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE
Sbjct: 61  PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE 120

Query: 121 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK 180
           NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK
Sbjct: 121 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK 180

Query: 181 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA 240
           ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA
Sbjct: 181 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA 240

Query: 241 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM 300
           CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM
Sbjct: 241 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM 300

Query: 301 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL 360
           VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL
Sbjct: 301 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL 360

Query: 361 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL 420
           TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL
Sbjct: 361 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL 420

Query: 421 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH 480
           YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH
Sbjct: 421 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH 480

Query: 481 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT 540
           FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT
Sbjct: 481 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT 540

Query: 541 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM 600
           NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM
Sbjct: 541 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM 600

Query: 601 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN 660
           PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN
Sbjct: 601 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN 660

Query: 661 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG 720
           DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG
Sbjct: 661 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG 720

Query: 721 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL 780
           CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL
Sbjct: 721 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL 780

Query: 781 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA 840
           KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA
Sbjct: 781 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA 840

Query: 841 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG 900
           GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG
Sbjct: 841 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG 900

Query: 901 SGKGAALITAVGVRLRTEASS 921
           SGKGAALITAVGVRLRTEASS
Sbjct: 901 SGKGAALITAVGVRLRTEASS 921


>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
          Length = 921

 Score = 1836 bits (4756), Expect = 0.0
 Identities = 921/921 (100%), Positives = 921/921 (100%)

Query: 1   MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN 60
           MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN
Sbjct: 1   MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFN 60

Query: 61  PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE 120
           PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE
Sbjct: 61  PTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE 120

Query: 121 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK 180
           NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK
Sbjct: 121 NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFK 180

Query: 181 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA 240
           ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA
Sbjct: 181 ASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNA 240

Query: 241 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM 300
           CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM
Sbjct: 241 CYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKM 300

Query: 301 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL 360
           VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL
Sbjct: 301 VSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEIL 360

Query: 361 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL 420
           TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL
Sbjct: 361 TRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSL 420

Query: 421 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH 480
           YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH
Sbjct: 421 YKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAH 480

Query: 481 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT 540
           FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT
Sbjct: 481 FHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGT 540

Query: 541 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM 600
           NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM
Sbjct: 541 NFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRM 600

Query: 601 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN 660
           PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN
Sbjct: 601 PLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVN 660

Query: 661 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG 720
           DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG
Sbjct: 661 DTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNG 720

Query: 721 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL 780
           CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL
Sbjct: 721 CLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETL 780

Query: 781 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA 840
           KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA
Sbjct: 781 KTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGA 840

Query: 841 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG 900
           GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG
Sbjct: 841 GMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDG 900

Query: 901 SGKGAALITAVGVRLRTEASS 921
           SGKGAALITAVGVRLRTEASS
Sbjct: 901 SGKGAALITAVGVRLRTEASS 921


>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
          Length = 917

 Score = 1788 bits (4632), Expect = 0.0
 Identities = 896/897 (99%), Positives = 897/897 (100%)

Query: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84
           +IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF
Sbjct: 21  KIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 80

Query: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144
           IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK
Sbjct: 81  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 140

Query: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204
           RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD
Sbjct: 141 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 200

Query: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264
           ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE
Sbjct: 201 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 260

Query: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324
           WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF
Sbjct: 261 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 320

Query: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384
           EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF
Sbjct: 321 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 380

Query: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444
           RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV
Sbjct: 381 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 440

Query: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504
           RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR
Sbjct: 441 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 500

Query: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564
           KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY
Sbjct: 501 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 560

Query: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624
           AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT
Sbjct: 561 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 620

Query: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684
           KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT
Sbjct: 621 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 680

Query: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744
           GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR
Sbjct: 681 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 740

Query: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804
           YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV
Sbjct: 741 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 800

Query: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864
           RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV
Sbjct: 801 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 860

Query: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 921
           DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 861 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 917



 Score =  495 bits (1275), Expect = e-140
 Identities = 235/447 (52%), Positives = 328/447 (73%)

Query: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528
           +Q ++I++ L    L+ + L+++  R R EM+ GL +  +  A VKMLP+FVR  PDG+E
Sbjct: 17  DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76

Query: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588
            GDF+ALDLGG++FR+L V++   K + V M +++Y  P  I+ G+G +LFDH+  C+ D
Sbjct: 77  KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136

Query: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648
           F++   IK  ++P+GFTFSFPCQQ+ +D  ILITWTK FKA+   G DVV LL  AIK+R
Sbjct: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196

Query: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708
            ++D ++VAVVNDTVGTMMTC Y++  CEVGLI+GTG+NACYMEE++++++VEGD+G+MC
Sbjct: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256

Query: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKM+SGMYLGE+VR IL+   K+
Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316

Query: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828
           G LF G+I+  L TRG F T  +S IE ++  L   + IL +LG+  + DD + V+ VC 
Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376

Query: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888
           +VS R+A L  A + A+++++R+N+G  RL  TVGVDG+LYK HP +SR  H+T++ L P
Sbjct: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP 436

Query: 889 KCNVSFLLSEDGSGKGAALITAVGVRL 915
             +V FLLSE GSGKGAA++TAV  RL
Sbjct: 437 DSDVRFLLSESGSGKGAAMVTAVAYRL 463


>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
          Length = 916

 Score = 1788 bits (4632), Expect = 0.0
 Identities = 897/899 (99%), Positives = 897/899 (99%)

Query: 23  ESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 82
           E  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG
Sbjct: 18  EIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 77

Query: 83  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 142
           DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM
Sbjct: 78  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 137

Query: 143 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 202
           EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD
Sbjct: 138 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 197

Query: 203 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 262
           YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN
Sbjct: 198 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 257

Query: 263 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 322
           TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL
Sbjct: 258 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 317

Query: 323 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 382
           LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV
Sbjct: 318 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 377

Query: 383 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 442
           SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS
Sbjct: 378 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 437

Query: 443 DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG 502
           DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG
Sbjct: 438 DVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELG 497

Query: 503 LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK 562
           LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK
Sbjct: 498 LRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNK 557

Query: 563 IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT 622
           IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT
Sbjct: 558 IYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILIT 617

Query: 623 WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV 682
           WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV
Sbjct: 618 WTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIV 677

Query: 683 GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK 742
           GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK
Sbjct: 678 GTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGK 737

Query: 743 QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL 802
           QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL
Sbjct: 738 QRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALL 797

Query: 803 QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV 862
           QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV
Sbjct: 798 QVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTV 857

Query: 863 GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 921
           GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 858 GVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 916


>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
          Length = 905

 Score = 1788 bits (4631), Expect = 0.0
 Identities = 896/896 (100%), Positives = 896/896 (100%)

Query: 26  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
           IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI
Sbjct: 10  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69

Query: 86  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 145
           ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR
Sbjct: 70  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 129

Query: 146 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 205
           KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA
Sbjct: 130 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 189

Query: 206 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 265
           NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW
Sbjct: 190 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 249

Query: 266 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 325
           GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE
Sbjct: 250 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 309

Query: 326 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 385
           GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR
Sbjct: 310 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 369

Query: 386 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 445
           SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR
Sbjct: 370 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 429

Query: 446 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 505
           FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK
Sbjct: 430 FLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRK 489

Query: 506 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 565
           QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA
Sbjct: 490 QTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYA 549

Query: 566 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 625
           IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK
Sbjct: 550 IPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTK 609

Query: 626 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 685
           GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG
Sbjct: 610 GFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTG 669

Query: 686 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 745
           SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY
Sbjct: 670 SNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRY 729

Query: 746 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 805
           EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR
Sbjct: 730 EKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVR 789

Query: 806 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 865
           AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD
Sbjct: 790 AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVD 849

Query: 866 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 921
           GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Sbjct: 850 GTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS 905



 Score =  494 bits (1271), Expect = e-139
 Identities = 235/445 (52%), Positives = 325/445 (73%)

Query: 471 HRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENG 530
           H  I++ L    L+ + L+++  R R EM+ GL +  +  A VKMLP+FVR  PDG+E G
Sbjct: 7   HDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 66

Query: 531 DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFL 590
           DF+ALDLGG++FR+L V++   K + V M +++Y  P  I+ G+G +LFDH+  C+ DF+
Sbjct: 67  DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFM 126

Query: 591 DYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREE 650
           +   IK  ++P+GFTFSFPCQQ+ +D  ILITWTK FKA+   G DVV LL  AIK+R +
Sbjct: 127 EKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGD 186

Query: 651 FDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCIN 710
           +D ++VAVVNDTVGTMMTC Y++  CEVGLI+GTG+NACYMEE++++++VEGD+G+MCIN
Sbjct: 187 YDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 246

Query: 711 MEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGF 770
            EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKM+SGMYLGE+VR IL+   K+G 
Sbjct: 247 TEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL 306

Query: 771 LFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVV 830
           LF G+I+  L TRG F T  +S IE ++  L   + IL +LG+  + DD + V+ VC +V
Sbjct: 307 LFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIV 366

Query: 831 SRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC 890
           S R+A L  A + A+++++R+N+G  RL  TVGVDG+LYK HP +SR  H+T++ L P  
Sbjct: 367 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDS 426

Query: 891 NVSFLLSEDGSGKGAALITAVGVRL 915
           +V FLLSE GSGKGAA++TAV  RL
Sbjct: 427 DVRFLLSESGSGKGAAMVTAVAYRL 451



 Score =  493 bits (1270), Expect = e-139
 Identities = 234/443 (52%), Positives = 325/443 (73%)

Query: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84
           +I++ L    L+ + L+++  R R EM+ GL +  +  A VKMLP+FVR  PDG+E GDF
Sbjct: 457 QIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDF 516

Query: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144
           +ALDLGG++FR+L V++   K + V M +++Y  P  I+ G+G +LFDH+  C+ DF++ 
Sbjct: 517 LALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDY 576

Query: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204
             IK  ++P+GFTFSFPCQQ+ +D  ILITWTK FKA+   G DVV LL  AIK+R ++D
Sbjct: 577 MGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFD 636

Query: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264
            ++VAVVNDTVGTMMTC Y++  CEVGLI+GTG+NACYMEE++++++VEGD+G+MCIN E
Sbjct: 637 LDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINME 696

Query: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324
           WGAFGD+G L+DIRT +DR +D  SLN GKQ +EKM+SGMYLGE+VR IL+   K+G LF
Sbjct: 697 WGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLF 756

Query: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384
            G+I+  L TRG F T  +S IE ++  L   + IL +LG+  + DD + V+ VC +VS 
Sbjct: 757 RGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSR 816

Query: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444
           R+A L  A + A+++++R+N+G  RL  TVGVDG+LYK HP +SR  H+T++ L P  +V
Sbjct: 817 RAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNV 876

Query: 445 RFLLSESGSGKGAAMVTAVAYRL 467
            FLLSE GSGKGAA++TAV  RL
Sbjct: 877 SFLLSEDGSGKGAALITAVGVRL 899


>gi|15553127 hexokinase 2 [Homo sapiens]
          Length = 917

 Score = 1369 bits (3543), Expect = 0.0
 Identities = 658/892 (73%), Positives = 776/892 (86%)

Query: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84
           ++D+YLY MRLSDETL++I  RFRKEM+ GL    +PTA VKMLPTFVRS PDG+E G+F
Sbjct: 21  KVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEF 80

Query: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144
           +ALDLGG++FR+L V+V     Q V ME+++Y  PE+I+ GSG+QLFDH+AECL +FM+K
Sbjct: 81  LALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDK 140

Query: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204
            +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++RGD+D
Sbjct: 141 LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFD 200

Query: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264
            +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMCIN E
Sbjct: 201 IDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINME 260

Query: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324
           WGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGMY+GELVRLILVKMAKE LLF
Sbjct: 261 WGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLF 320

Query: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384
            G+++PELL  G+F T D+S IE  K+G+  A+E+L RLG++P+ +DCV+   +C IVS 
Sbjct: 321 GGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVST 380

Query: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444
           RSA+L AATL A+L R+++NKG  RLR+T+GVDGS+YK HP +++R HKT+RRLVP  DV
Sbjct: 381 RSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDV 440

Query: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504
           RFL SE GSGKGAAMVTAVAYRLA+QHR  ++TL H  L+ D LLEVK+RM+ EME GL 
Sbjct: 441 RFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLS 500

Query: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564
           K+TH +A VKMLP++V  TPDGTE GDFLALDLGGTNFRVLLV++R+GK   VEMHNKIY
Sbjct: 501 KETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIY 560

Query: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624
           AIP E+M GTG+ELFDHIV CI+DFL+YMG+KG  +PLGFTFSFPCQQ SLD  IL+ WT
Sbjct: 561 AIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWT 620

Query: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684
           KGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVGTMMTC +E+P CEVGLIVGT
Sbjct: 621 KGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGT 680

Query: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744
           GSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD RT +D  VDE SLN GKQR
Sbjct: 681 GSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQR 740

Query: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804
           +EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LALLQV
Sbjct: 741 FEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV 800

Query: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864
           RAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAAVVD+IRENRGLD L VTVGV
Sbjct: 801 RAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGV 860

Query: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 916
           DGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKGAALITAV  R+R
Sbjct: 861 DGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 912



 Score =  546 bits (1406), Expect = e-155
 Identities = 258/447 (57%), Positives = 344/447 (76%)

Query: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528
           +Q +++++ L H  L+ + LLE+ KR R EME GL   TH  A VKMLP+FVR TPDGTE
Sbjct: 17  DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76

Query: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588
           +G+FLALDLGGTNFRVL VK+     + VEM N+IYAIP +IM+G+G +LFDHI  C+++
Sbjct: 77  HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136

Query: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648
           F+D + IK  ++PLGFTFSFPC QT LD   L++WTKGFK++   G DVV L+R AI+RR
Sbjct: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196

Query: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708
            +FD+D+VAVVNDTVGTMMTC Y++  CE+GLIVGTGSNACYMEEM++++MVEGD+G+MC
Sbjct: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256

Query: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768
           INMEWGAFGD+G L+DIRT +D+ +D  SLN GKQ +EKMISGMY+GE+VR IL+   K+
Sbjct: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316

Query: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828
             LF G++S  L   G FETK +S IE ++  + + R +L +LGL+ T +D +    +C 
Sbjct: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376

Query: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888
           +VS R+A LC A +AAV+ +I+EN+G +RL  T+GVDG++YK HPHF++ +H+TV+ L P
Sbjct: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436

Query: 889 KCNVSFLLSEDGSGKGAALITAVGVRL 915
            C+V FL SEDGSGKGAA++TAV  RL
Sbjct: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRL 463



 Score =  521 bits (1342), Expect = e-147
 Identities = 246/442 (55%), Positives = 336/442 (76%)

Query: 28  KYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIAL 87
           K L  ++LS + L+++  R + EM+ GLS++ + +A VKMLPT+V + PDG+EKGDF+AL
Sbjct: 472 KTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLAL 531

Query: 88  DLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKI 147
           DLGG++FR+L V+V + K   V M +++Y  P+ ++HG+G +LFDH+ +C+ DF+E   +
Sbjct: 532 DLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGM 591

Query: 148 KDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANI 207
           K   LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R ++D ++
Sbjct: 592 KGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDV 651

Query: 208 VAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGA 267
           VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC+N EWGA
Sbjct: 652 VAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGA 711

Query: 268 FGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGR 327
           FGD+G L+D RTEFD  +D  SLNPGKQ FEKM+SGMYLGE+VR IL+   K GLLF GR
Sbjct: 712 FGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGR 771

Query: 328 ITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSA 387
           I+  L TRG F T  +S IE +   L   + IL  LG+E + DD + V+ VCT+V+ R+A
Sbjct: 772 ISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAA 831

Query: 388 NLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFL 447
            L  A + A+++R+R+N+G   L+ TVGVDG+LYK HP +++  H+T++ L P  DV FL
Sbjct: 832 QLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFL 891

Query: 448 LSESGSGKGAAMVTAVAYRLAE 469
            SE GSGKGAA++TAVA R+ E
Sbjct: 892 QSEDGSGKGAALITAVACRIRE 913


>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
          Length = 917

 Score = 1323 bits (3425), Expect = 0.0
 Identities = 639/892 (71%), Positives = 765/892 (85%), Gaps = 1/892 (0%)

Query: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84
           ++D++LY MRLSD+TL+DIM RFR EM+ GL++D NPTA VKMLPTFVR+IPDGSE G+F
Sbjct: 21  KVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEF 80

Query: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144
           ++LDLGGS FR+L+VQV  E  ++V MES+ Y TP  I+ G+G++LF++VA+CL DFM+ 
Sbjct: 81  LSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKT 140

Query: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204
           + +K KKLP+G TFSFPC+Q+K++E +L++WTK+FKA GV+  DVV  L KA+++  D D
Sbjct: 141 KDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMD 200

Query: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264
            +I+A+VNDTVGTMMTC YDD +CEVG+IIGTGTNACYME++ +IDLVEGDEGRMCINTE
Sbjct: 201 VDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTE 260

Query: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324
           WGAFGDDG+LEDIRTEFDRE+D GSLNPGKQLFEKM+SG+YLGELVRLIL+KMAK GLLF
Sbjct: 261 WGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLF 320

Query: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384
            G  +  L T+GK  T  V+A+EK KEGL N +EIL  LG+EPS+ DC++VQHVCTIVSF
Sbjct: 321 GGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSF 380

Query: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444
           RSANL AA L AIL RLR+NK   RLRTTVG+DG+LYK HPQY +R HK +R+LVP  DV
Sbjct: 381 RSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDV 440

Query: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR 504
           RFLLSESGS KGAAMVTAVA R+  Q +QI+  LA F LT++ L++V+ +MRAE+E GL+
Sbjct: 441 RFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLK 500

Query: 505 KQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIY 564
           K++H  A V+MLP++V   PDGTE G FLALDLGGTNFRVLLVKIRSG +R+V M+NKI+
Sbjct: 501 KKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSG-RRSVRMYNKIF 559

Query: 565 AIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWT 624
           AIP+EIMQGTGEELFDHIV CI+DFLDYMG+KG  +PLGFTFSFPC+Q S+D G LI WT
Sbjct: 560 AIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWT 619

Query: 625 KGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGT 684
           KGFKATDC G DVV +LR+AIKRR EFDLD+VAVVNDTVGTMMTC YE+P CE+GLI GT
Sbjct: 620 KGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGT 679

Query: 685 GSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQR 744
           GSN CYME+M+N+EMVEG +G+MCIN EWG FGDNGC+DDIRT YD  VDE SLN GKQR
Sbjct: 680 GSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQR 739

Query: 745 YEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQV 804
           YEKM SGMYLGEIVR ILID TK+G LFRGQISE L+TRGIFETKFLSQIESDRLALLQV
Sbjct: 740 YEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQV 799

Query: 805 RAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGV 864
           R ILQQLGL+STC+DSI+VK VCG VSRRAAQLCGAG+AA+V+K RE++GL+ L +TVGV
Sbjct: 800 RRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGV 859

Query: 865 DGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLR 916
           DGTLYKLHPHFSRI+ +TVKEL+P+C+V+F+LSEDGSGKGAALITAV  RL+
Sbjct: 860 DGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQ 911



 Score =  498 bits (1282), Expect = e-140
 Identities = 235/450 (52%), Positives = 332/450 (73%)

Query: 469 EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTE 528
           +Q ++++  L H  L+ D LL++ +R RAEME GL K T+  A VKMLP+FVR  PDG+E
Sbjct: 17  DQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSE 76

Query: 529 NGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISD 588
           NG+FL+LDLGG+ FRVL V++    KR V+M ++ Y  P EI++G G ELF+++  C++D
Sbjct: 77  NGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLAD 136

Query: 589 FLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRR 648
           F+    +K  ++PLG TFSFPC+QT L+ G+L++WTK FKA      DVV+ L  A++R 
Sbjct: 137 FMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRH 196

Query: 649 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMC 708
           ++ D+D++A+VNDTVGTMMTCAY++P CEVG+I+GTG+NACYME+M N+++VEGD+G+MC
Sbjct: 197 KDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMC 256

Query: 709 INMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKK 768
           IN EWGAFGD+G L+DIRT +DR +D  SLN GKQ +EKMISG+YLGE+VR IL+   K 
Sbjct: 257 INTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKA 316

Query: 769 GFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 828
           G LF G+ S  L T+G  ET+ ++ +E  +  L   R IL  LGL  +  D I V+ VC 
Sbjct: 317 GLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCT 376

Query: 829 VVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 888
           +VS R+A LC A +AA++ ++REN+ ++RL  TVG+DGTLYK+HP + + +H+ V++L P
Sbjct: 377 IVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVP 436

Query: 889 KCNVSFLLSEDGSGKGAALITAVGVRLRTE 918
            C+V FLLSE GS KGAA++TAV  R++ +
Sbjct: 437 SCDVRFLLSESGSTKGAAMVTAVASRVQAQ 466



 Score =  494 bits (1272), Expect = e-139
 Identities = 234/449 (52%), Positives = 331/449 (73%), Gaps = 1/449 (0%)

Query: 25  EIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDF 84
           +ID+ L   +L+ E L+D+  + R E++ GL +  +  ATV+MLPT+V  +PDG+EKG F
Sbjct: 469 QIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKF 528

Query: 85  IALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEK 144
           +ALDLGG++FR+L V++   + ++V M ++++  P  I+ G+G +LFDH+ +C+ DF++ 
Sbjct: 529 LALDLGGTNFRVLLVKIRSGR-RSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDY 587

Query: 145 RKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYD 204
             +K   LP+GFTFSFPC+Q  ID+  LI WTK FKA+  EG DVV +L +AIK+R ++D
Sbjct: 588 MGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFD 647

Query: 205 ANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTE 264
            +IVAVVNDTVGTMMTCGY+D +CE+GLI GTG+N CYME++R+I++VEG EG+MCINTE
Sbjct: 648 LDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTE 707

Query: 265 WGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLF 324
           WG FGD+G ++DIRT +D E+D GSLNPGKQ +EKM SGMYLGE+VR IL+ + K+GLLF
Sbjct: 708 WGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLF 767

Query: 325 EGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSF 384
            G+I+  L TRG F T  +S IE ++  L   + IL +LG++ + +D + V+ VC  VS 
Sbjct: 768 RGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSR 827

Query: 385 RSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDV 444
           R+A L  A L AI+ + R+++G   LR TVGVDG+LYK HP +SR   +T++ L P  DV
Sbjct: 828 RAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDV 887

Query: 445 RFLLSESGSGKGAAMVTAVAYRLAEQHRQ 473
            F+LSE GSGKGAA++TAVA RL +  ++
Sbjct: 888 TFMLSEDGSGKGAALITAVAKRLQQAQKE 916


>gi|194097330 hexokinase 3 [Homo sapiens]
          Length = 923

 Score =  944 bits (2440), Expect = 0.0
 Identities = 478/892 (53%), Positives = 629/892 (70%), Gaps = 9/892 (1%)

Query: 26  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
           + + L   +++   L  I       M+  L    +P   V+MLPT+V S P G+E+GDF+
Sbjct: 33  VQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDFV 92

Query: 86  ALDLG--GSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 143
            L+LG  G+S R+L V +   +   V   S+ +  P+ ++ G+G QLFD  A CL +F++
Sbjct: 93  VLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLD 152

Query: 144 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 203
            + +  + L +GF+FSFPC Q+ +D + LI+WTK F+ SGVEG DVV+LL  AI+++G Y
Sbjct: 153 AQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQGAY 212

Query: 204 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 263
           + ++VAVVNDTVGTMM C    + CEVGL++ TGTNACYMEE RH+ +++ D GR+C++ 
Sbjct: 213 NIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVCVSV 272

Query: 264 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 323
           EWG+F DDG+L  + T FD  +D  SLNPG Q FEKM+ G+YLGELVRL+L  +A+ G+L
Sbjct: 273 EWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARCGVL 332

Query: 324 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 383
           F G  +P LL++G      V+ +E    G      IL  LG+ P   D   VQHVC  V 
Sbjct: 333 FGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCAAVC 392

Query: 384 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 443
            R+A L AA L A+L+ L+ ++    L+  V   G + + HP++      T+  L P+ D
Sbjct: 393 TRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAPECD 452

Query: 444 VRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGL 503
           V  + S  G G+G AMVTAVA RLA   R +EETLA F L  D L  V+ +MR  M  GL
Sbjct: 453 VSLIPSVDGGGRGVAMVTAVAARLAAHRRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGL 512

Query: 504 RKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKI 563
           R +  +   ++MLP+FVR TPDG+E GDFLALDLGGTNFRVLLV++ +G    V++ ++I
Sbjct: 513 RGEASS---LRMLPTFVRATPDGSERGDFLALDLGGTNFRVLLVRVTTG----VQITSEI 565

Query: 564 YAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITW 623
           Y+IP  + QG+G++LFDHIV CI DF    G+ G  +PLGFTFSFPC+Q  LD GIL+ W
Sbjct: 566 YSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNW 625

Query: 624 TKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVG 683
           TKGFKA+DC G DVV+LLR+AI RR+  +L+VVA+VNDTVGTMM+C YE+P CE+GLIVG
Sbjct: 626 TKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVG 685

Query: 684 TGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQ 743
           TG+NACYMEE++NV  V GD G+MCINMEWGAFGD+G L  + T +D  VD+ S+N GKQ
Sbjct: 686 TGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQ 745

Query: 744 RYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQ 803
           R+EKMISGMYLGEIVR+IL+  T  G LFRGQ  + L+TR IF+TKFLS+IESD LAL Q
Sbjct: 746 RFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQ 805

Query: 804 VRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVG 863
           VRAIL+ LGL  T DD+++V  VC  VS+RAAQLCGAG+AAVV+KIRENRGL+ L V+VG
Sbjct: 806 VRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVG 865

Query: 864 VDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRL 915
           VDGTLYKLHP FS ++  TV+EL+P+C V+FL SEDGSGKGAAL+TAV  RL
Sbjct: 866 VDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSEDGSGKGAALVTAVACRL 917



 Score =  463 bits (1192), Expect = e-130
 Identities = 232/447 (51%), Positives = 308/447 (68%), Gaps = 7/447 (1%)

Query: 26  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
           +++ L   RL+ + L  +  + RK M  GL  +    ++++MLPTFVR+ PDGSE+GDF+
Sbjct: 483 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGDFL 539

Query: 86  ALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKR 145
           ALDLGG++FR+L V+V       V + SE+Y  PE +  GSG QLFDH+ +C+ DF +K+
Sbjct: 540 ALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595

Query: 146 KIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDA 205
            +  + LP+GFTFSFPC+Q  +D+ IL+ WTK FKAS  EG DVV LL +AI +R   + 
Sbjct: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655

Query: 206 NIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEW 265
           N+VA+VNDTVGTMM+CGY+D  CE+GLI+GTGTNACYMEELR++  V GD GRMCIN EW
Sbjct: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 715

Query: 266 GAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFE 325
           GAFGDDGSL  + T FD  +D+ S+NPGKQ FEKM+SGMYLGE+VR IL+ +   G+LF 
Sbjct: 716 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 775

Query: 326 GRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFR 385
           G+    L TR  F T  +S IE +   L   + IL  LG+  + DD + V  VC  VS R
Sbjct: 776 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 835

Query: 386 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVR 445
           +A L  A + A++ ++R+N+G   L  +VGVDG+LYK HP++S     T+R L P   V 
Sbjct: 836 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 895

Query: 446 FLLSESGSGKGAAMVTAVAYRLAEQHR 472
           FL SE GSGKGAA+VTAVA RLA+  R
Sbjct: 896 FLQSEDGSGKGAALVTAVACRLAQLTR 922


>gi|15967161 glucokinase isoform 3 [Homo sapiens]
          Length = 464

 Score =  506 bits (1304), Expect = e-143
 Identities = 245/451 (54%), Positives = 336/451 (74%), Gaps = 2/451 (0%)

Query: 466 RLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPD 525
           +L + + Q+E+ LA F L ++ L +V +RM+ EM+ GLR +TH  A VKMLP++VR TP+
Sbjct: 7   QLPQPNSQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPE 66

Query: 526 GTENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIV 583
           G+E GDFL+LDLGGTNFRV+LVK+  G++   +V+  +++Y+IP + M GT E LFD+I 
Sbjct: 67  GSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYIS 126

Query: 584 SCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRD 643
            CISDFLD   +K  ++PLGFTFSFP +   +D GIL+ WTKGFKA+   G++VV LLRD
Sbjct: 127 ECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRD 186

Query: 644 AIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGD 703
           AIKRR +F++DVVA+VNDTV TM++C YE+  CEVG+IVGTG NACYMEEM+NVE+VEGD
Sbjct: 187 AIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGD 246

Query: 704 QGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILI 763
           +G+MC+N EWGAFGD+G LD+    YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+
Sbjct: 247 EGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLL 306

Query: 764 DFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILV 823
               +  LF G+ SE L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +V
Sbjct: 307 RLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIV 366

Query: 824 KTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTV 883
           +  C  VS RAA +C AG+A V++++RE+R  D + +TVGVDG++YKLHP F    H +V
Sbjct: 367 RRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASV 426

Query: 884 KELSPKCNVSFLLSEDGSGKGAALITAVGVR 914
           + L+P C ++F+ SE+GSG+GAAL++AV  +
Sbjct: 427 RRLTPSCEITFIESEEGSGRGAALVSAVACK 457



 Score =  476 bits (1225), Expect = e-134
 Identities = 223/447 (49%), Positives = 322/447 (72%), Gaps = 2/447 (0%)

Query: 24  SEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGD 83
           S++++ L   +L +E L  +M R +KEM  GL  + +  A+VKMLPT+VRS P+GSE GD
Sbjct: 13  SQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 72

Query: 84  FIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDF 141
           F++LDLGG++FR++ V+V    E   +V  + ++Y  PE+ + G+   LFD+++EC+ DF
Sbjct: 73  FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 132

Query: 142 MEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRG 201
           ++K ++K KKLP+GFTFSFP +   ID+ IL+ WTK FKASG EG +VV LL  AIK+RG
Sbjct: 133 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 192

Query: 202 DYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 261
           D++ ++VA+VNDTV TM++C Y+D  CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+
Sbjct: 193 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 252

Query: 262 NTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEG 321
           NTEWGAFGD G L++   E+DR +D  S NPG+QL+EK++ G Y+GELVRL+L+++  E 
Sbjct: 253 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 312

Query: 322 LLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTI 381
           LLF G  + +L TRG F T  VS +E +         IL+ LG+ PS  DC  V+  C  
Sbjct: 313 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 372

Query: 382 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPD 441
           VS R+A++ +A L  ++NR+R+++    +R TVGVDGS+YK HP +  RFH ++RRL P 
Sbjct: 373 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 432

Query: 442 SDVRFLLSESGSGKGAAMVTAVAYRLA 468
            ++ F+ SE GSG+GAA+V+AVA + A
Sbjct: 433 CEITFIESEEGSGRGAALVSAVACKKA 459


>gi|4503951 glucokinase isoform 1 [Homo sapiens]
          Length = 465

 Score =  504 bits (1298), Expect = e-142
 Identities = 244/449 (54%), Positives = 334/449 (74%), Gaps = 2/449 (0%)

Query: 468 AEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGT 527
           A +  ++E+ LA F L ++ L +V +RM+ EM+ GLR +TH  A VKMLP++VR TP+G+
Sbjct: 10  AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69

Query: 528 ENGDFLALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSC 585
           E GDFL+LDLGGTNFRV+LVK+  G++   +V+  +++Y+IP + M GT E LFD+I  C
Sbjct: 70  EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129

Query: 586 ISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAI 645
           ISDFLD   +K  ++PLGFTFSFP +   +D GIL+ WTKGFKA+   G++VV LLRDAI
Sbjct: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189

Query: 646 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQG 705
           KRR +F++DVVA+VNDTV TM++C YE+  CEVG+IVGTG NACYMEEM+NVE+VEGD+G
Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249

Query: 706 QMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDF 765
           +MC+N EWGAFGD+G LD+    YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+  
Sbjct: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309

Query: 766 TKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 825
             +  LF G+ SE L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +V+ 
Sbjct: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369

Query: 826 VCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKE 885
            C  VS RAA +C AG+A V++++RE+R  D + +TVGVDG++YKLHP F    H +V+ 
Sbjct: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429

Query: 886 LSPKCNVSFLLSEDGSGKGAALITAVGVR 914
           L+P C ++F+ SE+GSG+GAAL++AV  +
Sbjct: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458



 Score =  476 bits (1225), Expect = e-134
 Identities = 222/457 (48%), Positives = 326/457 (71%), Gaps = 2/457 (0%)

Query: 14  EKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVR 73
           ++ ++    + ++++ L   +L +E L  +M R +KEM  GL  + +  A+VKMLPT+VR
Sbjct: 4   DRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVR 63

Query: 74  SIPDGSEKGDFIALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLF 131
           S P+GSE GDF++LDLGG++FR++ V+V    E   +V  + ++Y  PE+ + G+   LF
Sbjct: 64  STPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLF 123

Query: 132 DHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVK 191
           D+++EC+ DF++K ++K KKLP+GFTFSFP +   ID+ IL+ WTK FKASG EG +VV 
Sbjct: 124 DYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVG 183

Query: 192 LLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDL 251
           LL  AIK+RGD++ ++VA+VNDTV TM++C Y+D  CEVG+I+GTG NACYMEE+++++L
Sbjct: 184 LLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVEL 243

Query: 252 VEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVR 311
           VEGDEGRMC+NTEWGAFGD G L++   E+DR +D  S NPG+QL+EK++ G Y+GELVR
Sbjct: 244 VEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVR 303

Query: 312 LILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDD 371
           L+L+++  E LLF G  + +L TRG F T  VS +E +         IL+ LG+ PS  D
Sbjct: 304 LVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTD 363

Query: 372 CVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRF 431
           C  V+  C  VS R+A++ +A L  ++NR+R+++    +R TVGVDGS+YK HP +  RF
Sbjct: 364 CDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERF 423

Query: 432 HKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLA 468
           H ++RRL P  ++ F+ SE GSG+GAA+V+AVA + A
Sbjct: 424 HASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKA 460


>gi|15967159 glucokinase isoform 2 [Homo sapiens]
          Length = 466

 Score =  503 bits (1294), Expect = e-142
 Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)

Query: 474 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 533
           +E+ LA F L ++ L +V +RM+ EM+ GLR +TH  A VKMLP++VR TP+G+E GDFL
Sbjct: 17  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76

Query: 534 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 591
           +LDLGGTNFRV+LVK+  G++   +V+  +++Y+IP + M GT E LFD+I  CISDFLD
Sbjct: 77  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136

Query: 592 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 651
              +K  ++PLGFTFSFP +   +D GIL+ WTKGFKA+   G++VV LLRDAIKRR +F
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196

Query: 652 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 711
           ++DVVA+VNDTV TM++C YE+  CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N 
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256

Query: 712 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 771
           EWGAFGD+G LD+    YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+    +  L
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316

Query: 772 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 831
           F G+ SE L+TRG FET+F+SQ+ESD     Q+  IL  LGL  +  D  +V+  C  VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376

Query: 832 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 891
            RAA +C AG+A V++++RE+R  D + +TVGVDG++YKLHP F    H +V+ L+P C 
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436

Query: 892 VSFLLSEDGSGKGAALITAVGVR 914
           ++F+ SE+GSG+GAAL++AV  +
Sbjct: 437 ITFIESEEGSGRGAALVSAVACK 459



 Score =  474 bits (1219), Expect = e-133
 Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)

Query: 26  IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
           +++ L   +L +E L  +M R +KEM  GL  + +  A+VKMLPT+VRS P+GSE GDF+
Sbjct: 17  VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76

Query: 86  ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 143
           +LDLGG++FR++ V+V    E   +V  + ++Y  PE+ + G+   LFD+++EC+ DF++
Sbjct: 77  SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136

Query: 144 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 203
           K ++K KKLP+GFTFSFP +   ID+ IL+ WTK FKASG EG +VV LL  AIK+RGD+
Sbjct: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196

Query: 204 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 263
           + ++VA+VNDTV TM++C Y+D  CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256

Query: 264 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 323
           EWGAFGD G L++   E+DR +D  S NPG+QL+EK++ G Y+GELVRL+L+++  E LL
Sbjct: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316

Query: 324 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 383
           F G  + +L TRG F T  VS +E +         IL+ LG+ PS  DC  V+  C  VS
Sbjct: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376

Query: 384 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 443
            R+A++ +A L  ++NR+R+++    +R TVGVDGS+YK HP +  RFH ++RRL P  +
Sbjct: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436

Query: 444 VRFLLSESGSGKGAAMVTAVAYRLA 468
           + F+ SE GSG+GAA+V+AVA + A
Sbjct: 437 ITFIESEEGSGRGAALVSAVACKKA 461


>gi|164663810 ribosomal modification protein rimK-like family member
           A [Homo sapiens]
          Length = 391

 Score = 34.7 bits (78), Expect = 0.42
 Identities = 33/143 (23%), Positives = 59/143 (41%), Gaps = 30/143 (20%)

Query: 582 IVSCISDFLDYMGIKGPRMPLGFTFSFPCQQT---------SLDAGILITWTKG------ 626
           I++CI+ F  +  + G  +P+  TFS+   +           L   +++  T+G      
Sbjct: 105 ILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHRGKAV 164

Query: 627 FKATD---------CVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYE---EP 674
           F A D          + HDV  L +  +K     D+ VV V    +G+M+ C+ +   + 
Sbjct: 165 FLARDKHHLSDICHLIRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCSTDGRMQS 224

Query: 675 TCEVGLIVGTGSNACYMEEMKNV 697
            C +G   G G      E+ K +
Sbjct: 225 NCSLG---GVGVKCPLTEQGKQL 244


>gi|134254462 ribosomal modification protein rimK-like family member
           B [Homo sapiens]
          Length = 386

 Score = 33.5 bits (75), Expect = 0.93
 Identities = 41/191 (21%), Positives = 75/191 (39%), Gaps = 51/191 (26%)

Query: 582 IVSCISDFLDYMGIKGPRMPLGFTFSFPCQQT---------SLDAGILITWTKG------ 626
           I++C++ F  +  + G  +PL  TFS+   +           L+  +++  T+G      
Sbjct: 109 ILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAV 168

Query: 627 FKATD---------CVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYE---EP 674
           F A D          + H+   L +  +K     D+ V+ V    VGTM+ C+ +   + 
Sbjct: 169 FLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQS 228

Query: 675 TCEVGLIVGTGSNACYMEEMK---------------NVEMVEGDQGQMCI-----NMEWG 714
            C +G   G G      E+ K                ++++  D G  C+     N+ + 
Sbjct: 229 NCSLG---GVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFI 285

Query: 715 AFGDNGCLDDI 725
           AF D  C  D+
Sbjct: 286 AF-DKACNLDV 295


>gi|21389509 KPL2 protein isoform 2 [Homo sapiens]
          Length = 514

 Score = 32.0 bits (71), Expect = 2.7
 Identities = 17/76 (22%), Positives = 37/76 (48%), Gaps = 2/76 (2%)

Query: 463 VAYRLAEQHRQIEETLAHFHLTK-DMLLEVKKRMRA-EMELGLRKQTHNNAVVKMLPSFV 520
           + YR  E+++ ++E LAH H  K +   ++K+  R  ++E     +   N ++  + + +
Sbjct: 155 ITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAI 214

Query: 521 RRTPDGTENGDFLALD 536
            + P    N    AL+
Sbjct: 215 IQIPKPASNRTLKALE 230


>gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
          Length = 1822

 Score = 32.0 bits (71), Expect = 2.7
 Identities = 17/76 (22%), Positives = 37/76 (48%), Gaps = 2/76 (2%)

Query: 463 VAYRLAEQHRQIEETLAHFHLTK-DMLLEVKKRMRA-EMELGLRKQTHNNAVVKMLPSFV 520
           + YR  E+++ ++E LAH H  K +   ++K+  R  ++E     +   N ++  + + +
Sbjct: 155 ITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAI 214

Query: 521 RRTPDGTENGDFLALD 536
            + P    N    AL+
Sbjct: 215 IQIPKPASNRTLKALE 230


>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform
           4 [Homo sapiens]
          Length = 3321

 Score = 31.6 bits (70), Expect = 3.5
 Identities = 28/118 (23%), Positives = 49/118 (41%), Gaps = 9/118 (7%)

Query: 9   SATAAEKPKL---HLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRD------F 59
           S  A EKP +    L  E E       MR+  E+L    +  +K ++N L ++       
Sbjct: 792 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYS 851

Query: 60  NPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYD 117
            P   +  +P +   +P   +      LD    +F  +  Q    K Q++H+E ++YD
Sbjct: 852 RPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD 909


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 31.6 bits (70), Expect = 3.5
 Identities = 28/118 (23%), Positives = 49/118 (41%), Gaps = 9/118 (7%)

Query: 9    SATAAEKPKL---HLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRD------F 59
            S  A EKP +    L  E E       MR+  E+L    +  +K ++N L ++       
Sbjct: 6197 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYS 6256

Query: 60   NPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYD 117
             P   +  +P +   +P   +      LD    +F  +  Q    K Q++H+E ++YD
Sbjct: 6257 RPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD 6314


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 31.6 bits (70), Expect = 3.5
 Identities = 28/118 (23%), Positives = 49/118 (41%), Gaps = 9/118 (7%)

Query: 9    SATAAEKPKL---HLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRD------F 59
            S  A EKP +    L  E E       MR+  E+L    +  +K ++N L ++       
Sbjct: 6268 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYS 6327

Query: 60   NPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYD 117
             P   +  +P +   +P   +      LD    +F  +  Q    K Q++H+E ++YD
Sbjct: 6328 RPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYD 6385


>gi|42415492 chromosome 14 open reading frame 106 [Homo sapiens]
          Length = 1132

 Score = 30.4 bits (67), Expect = 7.9
 Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 4/77 (5%)

Query: 281 FDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMA--KEGLLFEGRITPELLTRGKF 338
           F   I  G+L P K L +   S + L +  +   +KM       +F+  +  E  T    
Sbjct: 30  FFDSIPSGTLTPVKDLVKYQNSSLKLNDHKKNQFLKMTTFNNKNIFQSTMLTEATTSN-- 87

Query: 339 NTSDVSAIEKNKEGLHN 355
           ++ D+SAI+ NK+GL N
Sbjct: 88  SSLDISAIKPNKDGLKN 104


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,335,671
Number of Sequences: 37866
Number of extensions: 1405033
Number of successful extensions: 2795
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2746
Number of HSP's gapped (non-prelim): 36
length of query: 921
length of database: 18,247,518
effective HSP length: 112
effective length of query: 809
effective length of database: 14,006,526
effective search space: 11331279534
effective search space used: 11331279534
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.