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Search of human proteins with 157820785
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157820785 SH2 domain containing 7 [Homo sapiens]
(451 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157820785 SH2 domain containing 7 [Homo sapiens] 924 0.0
gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens] 115 1e-25
gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens] 115 1e-25
gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens] 115 1e-25
gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens] 115 1e-25
gi|239787752 SH2 domain protein 2A isoform 1 [Homo sapiens] 107 3e-23
gi|14249584 hematopoietic SH2 domain containing [Homo sapiens] 102 9e-22
gi|21361891 SH2 domain containing 4A [Homo sapiens] 86 7e-17
gi|111074524 Src homology 2 domain containing F [Homo sapiens] 54 2e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 54 4e-07
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 54 4e-07
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 54 4e-07
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 54 4e-07
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 54 4e-07
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 54 4e-07
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 52 1e-06
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 52 1e-06
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 49 7e-06
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 49 7e-06
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 49 9e-06
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 48 2e-05
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 48 2e-05
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 48 2e-05
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 47 4e-05
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 47 4e-05
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 47 5e-05
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 45 1e-04
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 45 1e-04
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 45 1e-04
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 45 1e-04
>gi|157820785 SH2 domain containing 7 [Homo sapiens]
Length = 451
Score = 924 bits (2389), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%)
Query: 1 MEDSLKQLSLGRDPEGAGDSQALAELQELALKWFMETQAPFILQNGALPPWFHGFITRKQ 60
MEDSLKQLSLGRDPEGAGDSQALAELQELALKWFMETQAPFILQNGALPPWFHGFITRKQ
Sbjct: 1 MEDSLKQLSLGRDPEGAGDSQALAELQELALKWFMETQAPFILQNGALPPWFHGFITRKQ 60
Query: 61 TEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLA 120
TEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLA
Sbjct: 61 TEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLA 120
Query: 121 ELVHHYQEAQLEPFKEMLTAACPRPEDNDLYDAITRGLHQTIVDPENPPATAFLTVVPDK 180
ELVHHYQEAQLEPFKEMLTAACPRPEDNDLYDAITRGLHQTIVDPENPPATAFLTVVPDK
Sbjct: 121 ELVHHYQEAQLEPFKEMLTAACPRPEDNDLYDAITRGLHQTIVDPENPPATAFLTVVPDK 180
Query: 181 AASPRSSPKPQVSFLHAQKSLDVSPRNLSQEESMEAPIRVSPLPEKSSSLLEESFGGPSD 240
AASPRSSPKPQVSFLHAQKSLDVSPRNLSQEESMEAPIRVSPLPEKSSSLLEESFGGPSD
Sbjct: 181 AASPRSSPKPQVSFLHAQKSLDVSPRNLSQEESMEAPIRVSPLPEKSSSLLEESFGGPSD 240
Query: 241 IIYADLRRMNQARLGLGTEGSGRHGPVPAGSQAYSPGREAQRRLSDGEQNRPDGLGPVLS 300
IIYADLRRMNQARLGLGTEGSGRHGPVPAGSQAYSPGREAQRRLSDGEQNRPDGLGPVLS
Sbjct: 241 IIYADLRRMNQARLGLGTEGSGRHGPVPAGSQAYSPGREAQRRLSDGEQNRPDGLGPVLS 300
Query: 301 GVSPDQGPTESPTSWGCSDAMGSLGATWRQEFPKLSQEAQPCSQGSSADIYEFIGTEGLL 360
GVSPDQGPTESPTSWGCSDAMGSLGATWRQEFPKLSQEAQPCSQGSSADIYEFIGTEGLL
Sbjct: 301 GVSPDQGPTESPTSWGCSDAMGSLGATWRQEFPKLSQEAQPCSQGSSADIYEFIGTEGLL 360
Query: 361 QEARDTPDQEGSTYEQIPACWGGPARAPHPGASPTYSPWVHGYKRISGTPELSEPGNTYE 420
QEARDTPDQEGSTYEQIPACWGGPARAPHPGASPTYSPWVHGYKRISGTPELSEPGNTYE
Sbjct: 361 QEARDTPDQEGSTYEQIPACWGGPARAPHPGASPTYSPWVHGYKRISGTPELSEPGNTYE 420
Query: 421 QIPATKSKETGRTHKPDKLRRLFFTYRKHKF 451
QIPATKSKETGRTHKPDKLRRLFFTYRKHKF
Sbjct: 421 QIPATKSKETGRTHKPDKLRRLFFTYRKHKF 451
>gi|239787762 SH2 domain protein 2A isoform 4 [Homo sapiens]
Length = 361
Score = 115 bits (287), Expect = 1e-25
Identities = 52/119 (43%), Positives = 77/119 (64%)
Query: 26 LQELALKWFMETQAPFILQNGALPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI 85
LQ WF +TQA ++LQ+GA P WFHGFITR++ E+LL K G +L+R S+ A ++
Sbjct: 42 LQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFV 101
Query: 86 LSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPR 144
L+YR CRHF++ QLR+ R+++ G+ +H+ L +L+ HY L P+ E LT R
Sbjct: 102 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 160
>gi|239787758 SH2 domain protein 2A isoform 3 [Homo sapiens]
Length = 371
Score = 115 bits (287), Expect = 1e-25
Identities = 52/119 (43%), Positives = 77/119 (64%)
Query: 26 LQELALKWFMETQAPFILQNGALPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI 85
LQ WF +TQA ++LQ+GA P WFHGFITR++ E+LL K G +L+R S+ A ++
Sbjct: 52 LQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFV 111
Query: 86 LSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPR 144
L+YR CRHF++ QLR+ R+++ G+ +H+ L +L+ HY L P+ E LT R
Sbjct: 112 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 170
>gi|239787750 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 115 bits (287), Expect = 1e-25
Identities = 52/119 (43%), Positives = 77/119 (64%)
Query: 26 LQELALKWFMETQAPFILQNGALPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI 85
LQ WF +TQA ++LQ+GA P WFHGFITR++ E+LL K G +L+R S+ A ++
Sbjct: 70 LQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFV 129
Query: 86 LSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPR 144
L+YR CRHF++ QLR+ R+++ G+ +H+ L +L+ HY L P+ E LT R
Sbjct: 130 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 188
>gi|239787783 SH2 domain protein 2A isoform 2 [Homo sapiens]
Length = 389
Score = 115 bits (287), Expect = 1e-25
Identities = 52/119 (43%), Positives = 77/119 (64%)
Query: 26 LQELALKWFMETQAPFILQNGALPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI 85
LQ WF +TQA ++LQ+GA P WFHGFITR++ E+LL K G +L+R S+ A ++
Sbjct: 70 LQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRREAERLLEPKPQGCYLVRFSESAVTFV 129
Query: 86 LSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPR 144
L+YR CRHF++ QLR+ R+++ G+ +H+ L +L+ HY L P+ E LT R
Sbjct: 130 LTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLAR 188
>gi|239787752 SH2 domain protein 2A isoform 1 [Homo sapiens]
Length = 399
Score = 107 bits (266), Expect = 3e-23
Identities = 52/129 (40%), Positives = 77/129 (59%), Gaps = 10/129 (7%)
Query: 26 LQELALKWFMETQAPFILQNGALPPWFHGFITRK----------QTEQLLRDKALGSFLI 75
LQ WF +TQA ++LQ+GA P WFHGFITR+ + E+LL K G +L+
Sbjct: 70 LQAETRAWFQKTQAHWLLQHGAAPAWFHGFITRRVRPPLSVTHREAERLLEPKPQGCYLV 129
Query: 76 RLSDRATGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFK 135
R S+ A ++L+YR CRHF++ QLR+ R+++ G+ +H+ L +L+ HY L P+
Sbjct: 130 RFSESAVTFVLTYRSRTCCRHFLLAQLRDGRHVVLGEDSAHARLQDLLLHYTAHPLSPYG 189
Query: 136 EMLTAACPR 144
E LT R
Sbjct: 190 ETLTEPLAR 198
>gi|14249584 hematopoietic SH2 domain containing [Homo sapiens]
Length = 352
Score = 102 bits (253), Expect = 9e-22
Identities = 66/200 (33%), Positives = 101/200 (50%), Gaps = 11/200 (5%)
Query: 31 LKWFMETQAPFILQNGALPPWFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYILSYRG 90
L WF+ TQ + Q+G +P WFHG I+R+ E LL + LGSFLIR+S GY LSY+
Sbjct: 15 LDWFVHTQMGQLAQDG-VPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKA 73
Query: 91 SDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPRPEDNDL 150
C HF++ L + ++I G+ +H++L LV +Q+ +EP +E+LT C R +D
Sbjct: 74 QSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPC-RQKDPAN 132
Query: 151 YDAITRGLHQTIVDPENPPATAFLTVVPDKAASPRSSPKPQVSFLHAQKSLDVSPRNLSQ 210
D L+ V E A P++A SPKP + ++ ++
Sbjct: 133 VDYEDLFLYSNAVAEE----AACPVSAPEEA-----SPKPVLCHQSKERKPSAEMNRITT 183
Query: 211 EESMEAPIRVSPLPEKSSSL 230
+E+ + SPL E L
Sbjct: 184 KEATSSCPPKSPLGETRQKL 203
>gi|21361891 SH2 domain containing 4A [Homo sapiens]
Length = 454
Score = 85.9 bits (211), Expect = 7e-17
Identities = 46/122 (37%), Positives = 69/122 (56%), Gaps = 6/122 (4%)
Query: 27 QELALKWFMETQAP----FILQNGALPPWFHGFITRKQTEQLLRDKAL-GSFLIRLSDRA 81
QE ++WF E Q P + + + PWFHG +T K+ +LL + GSFLIR+S+R
Sbjct: 319 QEDIIRWFKEEQLPLRAGYQKTSDTIAPWFHGILTLKKANELLLSTGMPGSFLIRVSERI 378
Query: 82 TGYILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPF-KEMLTA 140
GY LSY D C+HF+I+ + + D H+TLA+LV +++E + KE+L
Sbjct: 379 KGYALSYLSEDGCKHFLIDASADAYSFLGVDQLQHATLADLVEYHKEEPITSLGKELLLY 438
Query: 141 AC 142
C
Sbjct: 439 PC 440
>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
Length = 423
Score = 54.3 bits (129), Expect = 2e-07
Identities = 38/130 (29%), Positives = 65/130 (50%), Gaps = 6/130 (4%)
Query: 8 LSLGRDPEGAGDSQALAELQELALKWFMETQAPF-ILQNGALP----PWFHGFITRKQTE 62
LS GR+ +G + A + A ME +P + ALP W+HG I+R E
Sbjct: 275 LSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGAISRTDAE 334
Query: 63 QLLRDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAE 121
LLR S+L+R S+ + + LS + S H +++ + +Y++ ++ S++ E
Sbjct: 335 NLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPE 394
Query: 122 LVHHYQEAQL 131
+VHHY +L
Sbjct: 395 IVHHYASRKL 404
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/77 (37%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI-LSYRGSDRCRHFVINQLRNRRYII 109
W+HG ++R E LL GSFL+R S+ + G + +S R R H+ IN + + +
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217
Query: 110 SGDTQSHSTLAELVHHY 126
+ +++ STLAELVHH+
Sbjct: 218 TAESR-FSTLAELVHHH 233
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/77 (37%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI-LSYRGSDRCRHFVINQLRNRRYII 109
W+HG ++R E LL GSFL+R S+ + G + +S R R H+ IN + + +
Sbjct: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232
Query: 110 SGDTQSHSTLAELVHHY 126
+ +++ STLAELVHH+
Sbjct: 233 TAESR-FSTLAELVHHH 248
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/77 (37%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI-LSYRGSDRCRHFVINQLRNRRYII 109
W+HG ++R E LL GSFL+R S+ + G + +S R R H+ IN + + +
Sbjct: 152 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 211
Query: 110 SGDTQSHSTLAELVHHY 126
+ +++ STLAELVHH+
Sbjct: 212 TAESR-FSTLAELVHHH 227
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/77 (37%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI-LSYRGSDRCRHFVINQLRNRRYII 109
W+HG ++R E LL GSFL+R S+ + G + +S R R H+ IN + + +
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 217
Query: 110 SGDTQSHSTLAELVHHY 126
+ +++ STLAELVHH+
Sbjct: 218 TAESR-FSTLAELVHHH 233
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/77 (37%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYI-LSYRGSDRCRHFVINQLRNRRYII 109
W+HG ++R E LL GSFL+R S+ + G + +S R R H+ IN + + +
Sbjct: 137 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 196
Query: 110 SGDTQSHSTLAELVHHY 126
+ +++ STLAELVHH+
Sbjct: 197 TAESR-FSTLAELVHHH 212
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 53.5 bits (127), Expect = 4e-07
Identities = 25/87 (28%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 50 PWFHGFITRKQTEQLLRDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYI 108
PW+HG I+R + E L+ +L+R S+ Y ++ + S C H ++ Q ++ +Y
Sbjct: 394 PWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYT 453
Query: 109 ISGDTQSHSTLAELVHHYQEAQLEPFK 135
++ + ++ E+VH+Y +L PFK
Sbjct: 454 LNQTSAVFDSIPEVVHYYSNEKL-PFK 479
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 52.0 bits (123), Expect = 1e-06
Identities = 29/77 (37%), Positives = 45/77 (58%), Gaps = 2/77 (2%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGY-ILSYRGSDRCRHFVINQLRNRRYII 109
W+HG ++R E LL GSFL+R S+ + G +S R R H+ IN + + +
Sbjct: 127 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 186
Query: 110 SGDTQSHSTLAELVHHY 126
S +++ +TLAELVHH+
Sbjct: 187 SSESR-FNTLAELVHHH 202
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 52.0 bits (123), Expect = 1e-06
Identities = 29/77 (37%), Positives = 45/77 (58%), Gaps = 2/77 (2%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGY-ILSYRGSDRCRHFVINQLRNRRYII 109
W+HG ++R E LL GSFL+R S+ + G +S R R H+ IN + + +
Sbjct: 146 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 205
Query: 110 SGDTQSHSTLAELVHHY 126
S +++ +TLAELVHH+
Sbjct: 206 SSESR-FNTLAELVHHH 221
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 49.3 bits (116), Expect = 7e-06
Identities = 42/138 (30%), Positives = 63/138 (45%), Gaps = 19/138 (13%)
Query: 12 RDPEGAGDSQALAELQELALKWFMETQAPFILQNGALPPWFHGFITRKQTEQLLRDKALG 71
R P+ A S AL+++ ++ K E W+HG I R + ++LL K G
Sbjct: 433 RSPKSALGSSALSDMISISEKPLAEQD------------WYHGAIPRIEAQELL--KKQG 478
Query: 72 SFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELV-HHYQEA 129
FL+R S G Y+LS + RHF+I + N Y G S + +L+ HHY
Sbjct: 479 DFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN-MYRFEG--TGFSNIPQLIDHHYTTK 535
Query: 130 QLEPFKEMLTAACPRPED 147
Q+ K + P P+D
Sbjct: 536 QVITKKSGVVLLNPIPKD 553
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 49.3 bits (116), Expect = 7e-06
Identities = 35/124 (28%), Positives = 60/124 (48%), Gaps = 6/124 (4%)
Query: 18 GDSQALAELQELALKWFMETQAPFILQNGA---LPPWFHGFITRKQTEQLLRDKALGSFL 74
GD + QE K + +Q ++ +N P WFH ++R Q E LL K +G F+
Sbjct: 22 GDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFI 81
Query: 75 IRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEP 133
IR S + G + +S R D +HF + + Y + T+ +L +LV +Y+ +
Sbjct: 82 IRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLW--TEKFPSLNKLVDYYRTNSISR 139
Query: 134 FKEM 137
K++
Sbjct: 140 QKQI 143
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 48.9 bits (115), Expect = 9e-06
Identities = 34/131 (25%), Positives = 62/131 (47%), Gaps = 11/131 (8%)
Query: 50 PWFHGFITRKQTEQLL-RDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYI 108
PW++ ++R + E +L R G+FLIR + + Y +++R + +H IN R+ R+
Sbjct: 645 PWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRIN--RDGRHF 702
Query: 109 ISGDTQSHSTLAELVHHYQEAQL--------EPFKEMLTAACPRPEDNDLYDAITRGLHQ 160
+ G + +L ELV +Y++ L E+L + N LYD +
Sbjct: 703 VLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDP 762
Query: 161 TIVDPENPPAT 171
+ ++P P T
Sbjct: 763 SEINPSMPQRT 773
Score = 42.0 bits (97), Expect = 0.001
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 18/124 (14%)
Query: 51 WFHGFITRKQT-EQLLRDKAL------GSFLIRLSDR-ATGYILSYRGSDRCRHFVINQL 102
WFH + ++ + E+LL++ + G+FL+R S+ Y LS+ S R +H I
Sbjct: 532 WFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRST 591
Query: 103 RNR---RYIISGDTQSHSTLAELVHHYQEAQLE--PFKEMLTAACPRPEDND----LYDA 153
+Y ++ D + S++ L+ HY+E L F+ LT P P ++ YD+
Sbjct: 592 MEGGTLKYYLT-DNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDS 650
Query: 154 ITRG 157
++RG
Sbjct: 651 LSRG 654
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 4/97 (4%)
Query: 50 PWFHGFITRKQTEQ--LLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRY 107
PWFHG I+R+++EQ L+ K G FLIR D Y L + H+ I++ + +
Sbjct: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226
Query: 108 IISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPR 144
I + + TL +LV HY + + +LT C +
Sbjct: 227 SIP-EGKKFDTLWQLVEHY-SYKADGLLRVLTVPCQK 261
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/82 (30%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
Query: 50 PWFHGFITRKQTEQLLRDKAL--GSFLIRLS-DRATGYILSYRGSDRCRHFVINQLRNRR 106
P+F G ITR++ E L + G +L+R S + G+ LS + H+ I + N
Sbjct: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73
Query: 107 YIISGDTQSHSTLAELVHHYQE 128
Y I+G ++H++ A+L H++ +
Sbjct: 74 YAIAGG-RTHASPADLCHYHSQ 94
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/97 (31%), Positives = 49/97 (50%), Gaps = 4/97 (4%)
Query: 50 PWFHGFITRKQTEQ--LLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRY 107
PWFHG I+R+++EQ L+ K G FLIR D Y L + H+ I++ + +
Sbjct: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226
Query: 108 IISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPR 144
I + + TL +LV HY + + +LT C +
Sbjct: 227 SIP-EGKKFDTLWQLVEHY-SYKADGLLRVLTVPCQK 261
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/82 (30%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
Query: 50 PWFHGFITRKQTEQLLRDKAL--GSFLIRLS-DRATGYILSYRGSDRCRHFVINQLRNRR 106
P+F G ITR++ E L + G +L+R S + G+ LS + H+ I + N
Sbjct: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73
Query: 107 YIISGDTQSHSTLAELVHHYQE 128
Y I+G ++H++ A+L H++ +
Sbjct: 74 YAIAGG-RTHASPADLCHYHSQ 94
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 47.8 bits (112), Expect = 2e-05
Identities = 29/84 (34%), Positives = 48/84 (57%), Gaps = 5/84 (5%)
Query: 50 PWFHGFITRKQTEQLLRDKA-LGSFLIRLSDRA-TGYILSYRGSDRCRHFVINQLRNRRY 107
PW++G +TR Q E L ++ G FLIR S+ + + +S + + +HF + QL+ Y
Sbjct: 281 PWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKV-QLKETVY 339
Query: 108 IISGDTQSHSTLAELVHHYQEAQL 131
I + ST+ ELV HY++A +
Sbjct: 340 CIG--QRKFSTMEELVEHYKKAPI 361
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 47.0 bits (110), Expect = 4e-05
Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 4/92 (4%)
Query: 50 PWFHGFITRKQTEQLLRDKALGSFLIR-LSDRATGYILSYRGSDRCRHFVINQLRNRRYI 108
PWF G + R+QT+ LL+ A G++LIR A + +S + +D +H + + N +I
Sbjct: 672 PWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN--WI 729
Query: 109 ISGDTQSHSTLAELVHHYQEAQL-EPFKEMLT 139
+ + +L ELV +YQ L E FK++ T
Sbjct: 730 HITEAKKFDSLLELVEYYQCHSLKESFKQLDT 761
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 47.0 bits (110), Expect = 4e-05
Identities = 31/92 (33%), Positives = 51/92 (55%), Gaps = 4/92 (4%)
Query: 50 PWFHGFITRKQTEQLLRDKALGSFLIR-LSDRATGYILSYRGSDRCRHFVINQLRNRRYI 108
PWF G + R+QT+ LL+ A G++LIR A + +S + +D +H + + N +I
Sbjct: 662 PWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN--WI 719
Query: 109 ISGDTQSHSTLAELVHHYQEAQL-EPFKEMLT 139
+ + +L ELV +YQ L E FK++ T
Sbjct: 720 HITEAKKFDSLLELVEYYQCHSLKESFKQLDT 751
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 46.6 bits (109), Expect = 5e-05
Identities = 28/78 (35%), Positives = 44/78 (56%), Gaps = 3/78 (3%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATG-YILSYRGSDRCRHFVINQLRNRRYII 109
W+ G ++R++ + L+ + G FL+R S G Y+LS + R H++IN L NRR+ I
Sbjct: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
Query: 110 SGDTQSHSTLAELVHHYQ 127
GD Q L L+ Y+
Sbjct: 74 -GD-QEFDHLPALLEFYK 89
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/95 (34%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIIS 110
WF I R Q E LL K G+FLIR S + Y S +H VI R Y +
Sbjct: 358 WFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTA-RGYGFA 416
Query: 111 GDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPRP 145
+S+L ELV HYQ+ L + L P
Sbjct: 417 EPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYP 451
Score = 36.2 bits (82), Expect = 0.062
Identities = 29/108 (26%), Positives = 49/108 (45%), Gaps = 4/108 (3%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIR-LSDRATG-YILSYRGSDRCRHFVINQLRNRRYI 108
W+ G I+R++ LRD G+FL+R S + G Y L+ R + I R+ +Y
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYH-RDGKYG 123
Query: 109 ISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPRPEDNDLYDAITR 156
S D + +++ EL++HY L + L P D + +
Sbjct: 124 FS-DPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVK 170
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 45.4 bits (106), Expect = 1e-04
Identities = 33/95 (34%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIIS 110
WF I R Q E LL K G+FLIR S + Y S +H VI R Y +
Sbjct: 358 WFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTA-RGYGFA 416
Query: 111 GDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPRP 145
+S+L ELV HYQ+ L + L P
Sbjct: 417 EPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYP 451
Score = 36.2 bits (82), Expect = 0.062
Identities = 29/108 (26%), Positives = 49/108 (45%), Gaps = 4/108 (3%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIR-LSDRATG-YILSYRGSDRCRHFVINQLRNRRYI 108
W+ G I+R++ LRD G+FL+R S + G Y L+ R + I R+ +Y
Sbjct: 65 WYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYH-RDGKYG 123
Query: 109 ISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPRPEDNDLYDAITR 156
S D + +++ EL++HY L + L P D + +
Sbjct: 124 FS-DPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVK 170
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query: 51 WFHGFITRKQTEQLLRDKALGSFLIRLSDRATGYILSYRGSDRCRHFVINQLRNRRYIIS 110
W+ G I R Q E++L K G+FLIR S + Y S +H VI + + +
Sbjct: 622 WYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTAT-GFGFA 680
Query: 111 GDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPRP 145
+ +L ELV HYQ A L + LT P
Sbjct: 681 EPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHP 715
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 10/126 (7%)
Query: 39 APFILQNGALPP------WFHGFITRKQTEQLLRDKALGSFLIR-LSDRATG-YILSYRG 90
AP +L NG PP W+ G I+R++ + LRD G+FL+R S + G Y L+ R
Sbjct: 312 APTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRK 371
Query: 91 SDRCRHFVINQLRNRRYIISGDTQSHSTLAELVHHYQEAQLEPFKEMLTAACPRPEDNDL 150
+ + R+ Y S + + ++ +L++HY+ L + L P
Sbjct: 372 GGNNKLIKVFH-RDGHYGFS-EPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQ 429
Query: 151 YDAITR 156
D I +
Sbjct: 430 QDQIVK 435
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 45.1 bits (105), Expect = 1e-04
Identities = 30/83 (36%), Positives = 51/83 (61%), Gaps = 5/83 (6%)
Query: 51 WFHGFITRKQTEQLLRDKAL-GSFLIRLSDRA-TGYILSYRGSDRCRHFVINQLRNRRYI 108
W++G +TR Q E L ++ + G FLIR S+ + + + +S + S + +HF + QL + Y
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKV-QLVDNVYC 343
Query: 109 ISGDTQSHSTLAELVHHYQEAQL 131
I G + H T+ ELV HY++A +
Sbjct: 344 I-GQRRFH-TMDELVEHYKKAPI 364
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,331,728
Number of Sequences: 37866
Number of extensions: 1114040
Number of successful extensions: 3453
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 3275
Number of HSP's gapped (non-prelim): 316
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.