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Search of human proteins with 157676320
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157676320 SH3-binding domain kinase family, member 2 [Homo
sapiens]
(348 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157676320 SH3-binding domain kinase family, member 2 [Homo sa... 712 0.0
gi|66773086 SH3-binding kinase 1 [Homo sapiens] 213 2e-55
gi|166295196 checkpoint kinase 1 [Homo sapiens] 102 4e-22
gi|166295194 checkpoint kinase 1 [Homo sapiens] 102 4e-22
gi|166295192 checkpoint kinase 1 [Homo sapiens] 102 4e-22
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 99 6e-21
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 96 6e-20
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 94 1e-19
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 92 5e-19
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 89 4e-18
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 89 4e-18
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 89 4e-18
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 88 1e-17
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 88 1e-17
gi|116256471 SNF1-like kinase [Homo sapiens] 87 2e-17
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 86 5e-17
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 86 6e-17
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 85 1e-16
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 84 2e-16
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 84 2e-16
gi|133908623 protein kinase C, iota [Homo sapiens] 84 2e-16
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 84 2e-16
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 83 3e-16
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 83 3e-16
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 83 3e-16
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 83 3e-16
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 83 3e-16
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 82 5e-16
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 82 5e-16
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 82 5e-16
>gi|157676320 SH3-binding domain kinase family, member 2 [Homo
sapiens]
Length = 348
Score = 712 bits (1837), Expect = 0.0
Identities = 348/348 (100%), Positives = 348/348 (100%)
Query: 1 MPGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLSAQTLVRAEVDE 60
MPGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLSAQTLVRAEVDE
Sbjct: 1 MPGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLSAQTLVRAEVDE 60
Query: 61 LYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIV 120
LYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIV
Sbjct: 61 LYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIV 120
Query: 121 TAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGLV 180
TAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGLV
Sbjct: 121 TAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGLV 180
Query: 181 YRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPI 240
YRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPI
Sbjct: 181 YRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPI 240
Query: 241 QPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAPAA 300
QPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAPAA
Sbjct: 241 QPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAPAA 300
Query: 301 DALLRGLLDPHPRRRSAVIAIREHLGRPWRQREGEAEAVGAVEEEAGQ 348
DALLRGLLDPHPRRRSAVIAIREHLGRPWRQREGEAEAVGAVEEEAGQ
Sbjct: 301 DALLRGLLDPHPRRRSAVIAIREHLGRPWRQREGEAEAVGAVEEEAGQ 348
>gi|66773086 SH3-binding kinase 1 [Homo sapiens]
Length = 424
Score = 213 bits (542), Expect = 2e-55
Identities = 117/273 (42%), Positives = 159/273 (58%), Gaps = 3/273 (1%)
Query: 43 EDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRG 102
EDM L+ +TL ++V + YE VR LG+G YG+V LV ++ GT +ALK + K +T L+
Sbjct: 34 EDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKN 93
Query: 103 FLYEFCVGLSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHR 162
FL E + SL + I+ + + E+ Y F E GDL I P+VGLP+ V R
Sbjct: 94 FLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKR 153
Query: 163 CAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIP 222
C QL AL+++H R LV+RD+KPENVL+ D CRR KL DFG TR G ++ IP
Sbjct: 154 CVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIP 213
Query: 223 YTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQA 282
YTAPE+C +GL + +D WA GVL+FC+LTG FPW+ + AD F+E+F+ WQ
Sbjct: 214 YTAPEVC-QAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWE-AASGADAFFEEFVRWQR 271
Query: 283 SGQPRDRPQPWFGLAPAADALLRGLLDPHPRRR 315
P P W A + + LL P RR
Sbjct: 272 GRLP-GLPSQWRRFTEPALRMFQRLLALEPERR 303
>gi|166295196 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 102 bits (255), Expect = 4e-22
Identities = 82/271 (30%), Positives = 128/271 (47%), Gaps = 23/271 (8%)
Query: 60 ELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRT--SLRGFLYEFCVGLSLGAHS 117
E ++ V+ LG+G YG V L +R +A+K + R E C+ L H
Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLN-HE 65
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
+V YG E Y FL E G+L I+P +G+P+P R QL + + Y+H
Sbjct: 66 NVVKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGI 124
Query: 178 GLVYRDLKPENVLVCDPACRRFKLTDFG-----HTRPRGTLLRLAGPPIPYTAPELCAPP 232
G+ +RD+KPEN+L+ + K++DFG R LL +PY APEL
Sbjct: 125 GITHRDIKPENLLLDER--DNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK-- 180
Query: 233 PLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQP 292
+P +D W+ G++L +L G PWD+P +++ Y D W+ + + P
Sbjct: 181 --RREFHAEP-VDVWSCGIVLTAMLAGELPWDQP-SDSCQEYSD---WK---EKKTYLNP 230
Query: 293 WFGLAPAADALLRGLLDPHPRRRSAVIAIRE 323
W + A ALL +L +P R + I++
Sbjct: 231 WKKIDSAPLALLHKILVENPSARITIPDIKK 261
>gi|166295194 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 102 bits (255), Expect = 4e-22
Identities = 82/271 (30%), Positives = 128/271 (47%), Gaps = 23/271 (8%)
Query: 60 ELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRT--SLRGFLYEFCVGLSLGAHS 117
E ++ V+ LG+G YG V L +R +A+K + R E C+ L H
Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLN-HE 65
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
+V YG E Y FL E G+L I+P +G+P+P R QL + + Y+H
Sbjct: 66 NVVKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGI 124
Query: 178 GLVYRDLKPENVLVCDPACRRFKLTDFG-----HTRPRGTLLRLAGPPIPYTAPELCAPP 232
G+ +RD+KPEN+L+ + K++DFG R LL +PY APEL
Sbjct: 125 GITHRDIKPENLLLDER--DNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK-- 180
Query: 233 PLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQP 292
+P +D W+ G++L +L G PWD+P +++ Y D W+ + + P
Sbjct: 181 --RREFHAEP-VDVWSCGIVLTAMLAGELPWDQP-SDSCQEYSD---WK---EKKTYLNP 230
Query: 293 WFGLAPAADALLRGLLDPHPRRRSAVIAIRE 323
W + A ALL +L +P R + I++
Sbjct: 231 WKKIDSAPLALLHKILVENPSARITIPDIKK 261
>gi|166295192 checkpoint kinase 1 [Homo sapiens]
Length = 476
Score = 102 bits (255), Expect = 4e-22
Identities = 82/271 (30%), Positives = 128/271 (47%), Gaps = 23/271 (8%)
Query: 60 ELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRT--SLRGFLYEFCVGLSLGAHS 117
E ++ V+ LG+G YG V L +R +A+K + R E C+ L H
Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLN-HE 65
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
+V YG E Y FL E G+L I+P +G+P+P R QL + + Y+H
Sbjct: 66 NVVKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGI 124
Query: 178 GLVYRDLKPENVLVCDPACRRFKLTDFG-----HTRPRGTLLRLAGPPIPYTAPELCAPP 232
G+ +RD+KPEN+L+ + K++DFG R LL +PY APEL
Sbjct: 125 GITHRDIKPENLLLDER--DNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK-- 180
Query: 233 PLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQP 292
+P +D W+ G++L +L G PWD+P +++ Y D W+ + + P
Sbjct: 181 --RREFHAEP-VDVWSCGIVLTAMLAGELPWDQP-SDSCQEYSD---WK---EKKTYLNP 230
Query: 293 WFGLAPAADALLRGLLDPHPRRRSAVIAIRE 323
W + A ALL +L +P R + I++
Sbjct: 231 WKKIDSAPLALLHKILVENPSARITIPDIKK 261
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 99.0 bits (245), Expect = 6e-21
Identities = 89/290 (30%), Positives = 133/290 (45%), Gaps = 19/290 (6%)
Query: 39 ARALEDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRT 98
A AL+DM+ L T ++ +YE LG G + V+L R +ALK +PK
Sbjct: 78 AIALQDMLLLKKHT---EDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL 134
Query: 99 SLRGFLYEFCVG-LSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQ 157
+ L E + L +H IV + +H Y + E V G+L I + +
Sbjct: 135 RGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAM-ELVTGGELFDRIMERGSYTE 193
Query: 158 PAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDP-ACRRFKLTDFGHTR-PRGTLLR 215
Q+ A+ Y+H+ G+V+RDLKPEN+L P + ++DFG ++ G +L
Sbjct: 194 KDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG 253
Query: 216 LAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYE 275
A Y APEL E P A+D WALGV+ + LL GY P+ E+DP E
Sbjct: 254 TACGTPGYVAPELL------EQKPYGKAVDVWALGVISYILLCGYPPF---YDESDP--E 302
Query: 276 DFLIWQASGQPRDRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHL 325
F + D P W ++ +A +R LL+ P++R HL
Sbjct: 303 LFSQILRASYEFDSPF-WDDISESAKDFIRHLLERDPQKRFTCQQALRHL 351
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 95.5 bits (236), Expect = 6e-20
Identities = 88/294 (29%), Positives = 131/294 (44%), Gaps = 19/294 (6%)
Query: 35 GQEAARALEDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLP 94
G R DM+ L T ++ +YE LG G + V+L R +ALK +P
Sbjct: 8 GLAGRRPSGDMLLLKKHT---EDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIP 64
Query: 95 KPRTSLRGFLYEFCVG-LSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKV 153
K + L E + L +H IV + +H Y + E V G+L I +
Sbjct: 65 KKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAM-ELVTGGELFDRIMERG 123
Query: 154 GLPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDP-ACRRFKLTDFGHTR-PRG 211
+ Q+ A+ Y+H+ G+V+RDLKPEN+L P + ++DFG ++ G
Sbjct: 124 SYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAG 183
Query: 212 TLLRLAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEAD 271
+L A Y APEL E P A+D WALGV+ + LL GY P+ E+D
Sbjct: 184 NMLGTACGTPGYVAPELL------EQKPYGKAVDVWALGVISYILLCGYPPF---YDESD 234
Query: 272 PFYEDFLIWQASGQPRDRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHL 325
P E F + D P W ++ +A +R LL+ P++R HL
Sbjct: 235 P--ELFSQILRASYEFDSPF-WDDISESAKDFIRHLLERDPQKRFTCQQALRHL 285
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 94.4 bits (233), Expect = 1e-19
Identities = 86/295 (29%), Positives = 133/295 (45%), Gaps = 27/295 (9%)
Query: 53 LVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLY--EFCVG 110
++ A V++ YE R +G G + V HR+ A+K + K R + + E +
Sbjct: 347 IIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILII 406
Query: 111 LSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASA 170
SL +H IV + + Y L E V GDL I V P+P L A
Sbjct: 407 QSL-SHPNIVKLHEVYETDMEIYLIL-EYVQGGDLFDAIIESVKFPEPDAALMIMDLCKA 464
Query: 171 LEYIHARGLVYRDLKPENVLV--CDPACRRFKLTDFG----HTRPRGTLLRLAGPPIPYT 224
L ++H + +V+RDLKPEN+LV + KL DFG RP + + G P Y
Sbjct: 465 LVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRP---IFTVCGTP-TYV 520
Query: 225 APELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASG 284
APE+ + +G ++ +D WA GV+L+ LL G+ P+ P + D + + G
Sbjct: 521 APEILS----EKGYGLE--VDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQL----G 570
Query: 285 QPRDRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQREGEAEAV 339
P W ++ AA L+ LL P++R + +H PW + G+ V
Sbjct: 571 HFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQH---PWIETAGKTNTV 622
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 92.4 bits (228), Expect = 5e-19
Identities = 85/277 (30%), Positives = 128/277 (46%), Gaps = 32/277 (11%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTS----LRGFLYEFCVGLSLGAHS 117
YE LG+G YG+V T R G +A+K + K + + E + SL H
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLN-HP 113
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
I++ Y + E+ + E G+L +I + L + Q+ SA+ Y H
Sbjct: 114 HIISIYEV-FENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKN 172
Query: 178 GLVYRDLKPENVLVCDPACRRFKLTDFGHT---RPRGTLLRLAGPPIPYTAPELCAPPPL 234
G+V+RDLK EN+L+ D K+ DFG + + L G P+ Y +PE+
Sbjct: 173 GVVHRDLKLENILLDDNC--NIKIADFGLSNLYQKDKFLQTFCGSPL-YASPEIV----- 224
Query: 235 PEGLPIQ-PALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQ-ASGQPRDRPQP 292
G P + P +D+WALGVLL+ L+ G P+ D F LI Q +SG+ R+ QP
Sbjct: 225 -NGRPYRGPEVDSWALGVLLYTLVYGTMPF-------DGFDHKNLIRQISSGEYREPTQP 276
Query: 293 WFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPW 329
A L+R +L +P RR+ + I H W
Sbjct: 277 -----SDARGLIRWMLMVNPDRRATIEDIANHWWVNW 308
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 89.4 bits (220), Expect = 4e-18
Identities = 80/269 (29%), Positives = 123/269 (45%), Gaps = 35/269 (13%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKP-----------RTSLRGFLYEFCVG 110
++ +R +G+G Y +VLLV ++ A+K + K +T F
Sbjct: 69 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP 128
Query: 111 LSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASA 170
+G HS T + + + E V GDLM +Q + LP+ AA++ A
Sbjct: 129 FLVGLHSCFQTTSRLFL--------VIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 171 LEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTR----PRGTLLRLAGPPIPYTAP 226
L ++H RG++YRDLK +NVL+ A KLTD+G + P T G P Y AP
Sbjct: 181 LNFLHERGIIYRDLKLDNVLL--DADGHIKLTDYGMCKEGLGPGDTTSTFCGTP-NYIAP 237
Query: 227 ELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQP 286
E+ G ++D WALGVL+F ++ G P+D D ED+L +P
Sbjct: 238 EIL------RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKP 291
Query: 287 RDRPQPWFGLAPAADALLRGLLDPHPRRR 315
P+ L+ A +L+G L+ P+ R
Sbjct: 292 IRIPR---FLSVKASHVLKGFLNKDPKER 317
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 89.4 bits (220), Expect = 4e-18
Identities = 80/269 (29%), Positives = 123/269 (45%), Gaps = 35/269 (13%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKP-----------RTSLRGFLYEFCVG 110
++ +R +G+G Y +VLLV ++ A+K + K +T F
Sbjct: 69 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP 128
Query: 111 LSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASA 170
+G HS T + + + E V GDLM +Q + LP+ AA++ A
Sbjct: 129 FLVGLHSCFQTTSRLFL--------VIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 171 LEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTR----PRGTLLRLAGPPIPYTAP 226
L ++H RG++YRDLK +NVL+ A KLTD+G + P T G P Y AP
Sbjct: 181 LNFLHERGIIYRDLKLDNVLL--DADGHIKLTDYGMCKEGLGPGDTTSTFCGTP-NYIAP 237
Query: 227 ELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQP 286
E+ G ++D WALGVL+F ++ G P+D D ED+L +P
Sbjct: 238 EIL------RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKP 291
Query: 287 RDRPQPWFGLAPAADALLRGLLDPHPRRR 315
P+ L+ A +L+G L+ P+ R
Sbjct: 292 IRIPR---FLSVKASHVLKGFLNKDPKER 317
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 89.4 bits (220), Expect = 4e-18
Identities = 80/269 (29%), Positives = 123/269 (45%), Gaps = 35/269 (13%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKP-----------RTSLRGFLYEFCVG 110
++ +R +G+G Y +VLLV ++ A+K + K +T F
Sbjct: 252 FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP 311
Query: 111 LSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASA 170
+G HS T + + + E V GDLM +Q + LP+ AA++ A
Sbjct: 312 FLVGLHSCFQTTSRLFL--------VIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 363
Query: 171 LEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTR----PRGTLLRLAGPPIPYTAP 226
L ++H RG++YRDLK +NVL+ A KLTD+G + P T G P Y AP
Sbjct: 364 LNFLHERGIIYRDLKLDNVLL--DADGHIKLTDYGMCKEGLGPGDTTSTFCGTP-NYIAP 420
Query: 227 ELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQP 286
E+ G ++D WALGVL+F ++ G P+D D ED+L +P
Sbjct: 421 EIL------RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKP 474
Query: 287 RDRPQPWFGLAPAADALLRGLLDPHPRRR 315
P+ L+ A +L+G L+ P+ R
Sbjct: 475 IRIPR---FLSVKASHVLKGFLNKDPKER 500
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 87.8 bits (216), Expect = 1e-17
Identities = 70/234 (29%), Positives = 113/234 (48%), Gaps = 14/234 (5%)
Query: 39 ARALEDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRT 98
A+A ED + + +E ++ LG G +GRV+LV H++ G A+K L K +
Sbjct: 13 AKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKV 72
Query: 99 -SLRGFLYEFCVGLSLGA-HSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLP 156
L+ + L A + + + + + E V G++ + ++
Sbjct: 73 VKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 132
Query: 157 QPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHT-RPRGTLLR 215
+P AAQ+ EY+H+ L+YRDLKPEN+L+ ++TDFG R +G
Sbjct: 133 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG--YIQVTDFGFAKRVKGRTWT 190
Query: 216 LAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPW--DRPL 267
L G P Y APE+ L +G A+D WALGVL++ + GY P+ D+P+
Sbjct: 191 LCGTP-EYLAPEII----LSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQPI 237
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 87.8 bits (216), Expect = 1e-17
Identities = 70/234 (29%), Positives = 113/234 (48%), Gaps = 14/234 (5%)
Query: 39 ARALEDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRT 98
A+A ED + + +E ++ LG G +GRV+LV H++ G A+K L K +
Sbjct: 21 AKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKV 80
Query: 99 -SLRGFLYEFCVGLSLGA-HSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLP 156
L+ + L A + + + + + E V G++ + ++
Sbjct: 81 VKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFS 140
Query: 157 QPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHT-RPRGTLLR 215
+P AAQ+ EY+H+ L+YRDLKPEN+L+ ++TDFG R +G
Sbjct: 141 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG--YIQVTDFGFAKRVKGRTWT 198
Query: 216 LAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPW--DRPL 267
L G P Y APE+ L +G A+D WALGVL++ + GY P+ D+P+
Sbjct: 199 LCGTP-EYLAPEII----LSKG--YNKAVDWWALGVLIYEMAAGYPPFFADQPI 245
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 87.0 bits (214), Expect = 2e-17
Identities = 80/269 (29%), Positives = 125/269 (46%), Gaps = 26/269 (9%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGF--LYEFCVGLSLGAHSAI 119
Y+ R LG+G + V L HR T +A+K + K R +Y + L H I
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHI 86
Query: 120 VTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGL 179
+ Y + +E+ +TE +G++ ++ L + + Q+ SA+EY H +
Sbjct: 87 IKLYQV-METKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145
Query: 180 VYRDLKPENVLVCDPACRRFKLTDFG---HTRPRGTLLRLAGPPIPYTAPELCAPPPLPE 236
V+RDLK EN+L+ KL DFG + L G P PY APE+ E
Sbjct: 146 VHRDLKTENLLL--DGNMDIKLADFGFGNFYKSGEPLSTWCGSP-PYAAPEVF------E 196
Query: 237 GLPIQ-PALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFG 295
G + P LD W+LGV+L+ L+ G P+D P + Q + R R P+F
Sbjct: 197 GKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPT--------LRQRVLEGRFR-IPFF- 246
Query: 296 LAPAADALLRGLLDPHPRRRSAVIAIREH 324
++ ++L+R +L P RR + IR+H
Sbjct: 247 MSQDCESLIRRMLVVDPARRITIAQIRQH 275
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 85.9 bits (211), Expect = 5e-17
Identities = 89/350 (25%), Positives = 138/350 (39%), Gaps = 23/350 (6%)
Query: 4 KQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLSAQTLVRAEVDELYE 63
K S P G+ ++ G + + G E R + + + + E Y+
Sbjct: 336 KSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYK 395
Query: 64 EVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIVTAY 123
+ +G G + V R G ALK + K + + L E V + +
Sbjct: 396 IGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIML 455
Query: 124 GIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGLVYRD 183
+E+A + E V GDL I + LA+AL Y+H +V+RD
Sbjct: 456 VEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRD 515
Query: 184 LKPENVLVCD--PACRRFKLTDFG-HTRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPI 240
+KPEN+LVC+ + KL DFG T G L + G P Y APE+ A GL +
Sbjct: 516 IKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTP-TYVAPEIIAETGY--GLKV 572
Query: 241 QPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAPAA 300
D WA GV+ + LL G FP P + ED +G+ W + +A
Sbjct: 573 ----DIWAAGVITYILLCG-FP---PFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSA 624
Query: 301 DALLRGLLDPHPRRRSAVIAIREHLGRPW------RQREGEAEAVGAVEE 344
L+ +L + R I H PW ++ +AE G +++
Sbjct: 625 KELISQMLQVNVEARCTAGQILSH---PWVSDDASQENNMQAEVTGKLKQ 671
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 85.5 bits (210), Expect = 6e-17
Identities = 73/248 (29%), Positives = 121/248 (48%), Gaps = 20/248 (8%)
Query: 28 TLEELQQGQEAARALEDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTP 87
T +E + A+A D + + +E +R LG G +GRV+LV H++ G
Sbjct: 10 TEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGH 69
Query: 88 LALKQLPKPRT----SLRGFLYEFCVGLSLGAHSAIVTAYGIGIESAHSYSFLT-EPVLH 142
A+K L K + + L E + ++ + + +SY +L E V
Sbjct: 70 YAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSF---KDNSYLYLVMEYVPG 126
Query: 143 GDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLT 202
G++ + +Q +P AAQ+ A++Y+H+ L++RDLKPEN+L+ ++T
Sbjct: 127 GEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQG--YLQVT 184
Query: 203 DFGHT-RPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYF 261
DFG R +G L G P Y APE+ L +G A+D WALGVL++ + G+
Sbjct: 185 DFGFAKRVKGRTWTLCGTP-EYLAPEII----LSKG--YNKAVDWWALGVLIYEMAVGFP 237
Query: 262 PW--DRPL 267
P+ D+P+
Sbjct: 238 PFYADQPI 245
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 84.7 bits (208), Expect = 1e-16
Identities = 79/269 (29%), Positives = 114/269 (42%), Gaps = 28/269 (10%)
Query: 68 LGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIVTAYGIGI 127
LG G + V LV R G ALK + K L L H IVT I
Sbjct: 29 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDI-Y 87
Query: 128 ESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHARGLVYRDLKPE 187
ES Y + + V G+L I + + Q+ SA++Y+H G+V+RDLKPE
Sbjct: 88 ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPE 147
Query: 188 NVLVCDP-ACRRFKLTDFGHTR--PRGTLLRLAGPPIPYTAPELCAPPPLPEGLPIQPAL 244
N+L P + +TDFG ++ G + G P Y APE+ A P + A+
Sbjct: 148 NLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTP-GYVAPEVLAQKPYSK------AV 200
Query: 245 DAWALGVLLFCLLTGYFPWDRPLAEADPFYEDF---LIWQASGQPRDRPQP-WFGLAPAA 300
D W++GV+ + LL GY PFYE+ L + + P W ++ +A
Sbjct: 201 DCWSIGVITYILLCGY----------PPFYEETESKLFEKIKEGYYEFESPFWDDISESA 250
Query: 301 DALLRGLLDPHPRRRSAVIAIREHLGRPW 329
+ LL+ P R + L PW
Sbjct: 251 KDFICHLLEKDPNER---YTCEKALSHPW 276
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 84.0 bits (206), Expect = 2e-16
Identities = 85/300 (28%), Positives = 139/300 (46%), Gaps = 26/300 (8%)
Query: 46 MTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLY 105
+T+ Q++ + + Y + LG G G V L R+ +A+K + K + ++ G
Sbjct: 247 LTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAI-GSAR 305
Query: 106 EFCVGLSLGAHSAIVTAYG----IGIES---AHSYSFLTEPVLHGDLMAFIQPKVGLPQP 158
E L++ I+ I I++ A Y + E + G+L + L +
Sbjct: 306 EADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEA 365
Query: 159 AVHRCAAQLASALEYIHARGLVYRDLKPENVLVC--DPACRRFKLTDFGHTRPRG--TLL 214
Q+ A++Y+H G+++RDLKPENVL+ + C K+TDFGH++ G +L+
Sbjct: 366 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLM 424
Query: 215 R-LAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPF 273
R L G P Y APE+ A+D W+LGV+LF L+GY P+ +
Sbjct: 425 RTLCGTP-TYLAPEVLVSVGT---AGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS-- 478
Query: 274 YEDFLIWQASGQPRDRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQRE 333
+D + SG+ P+ W ++ A L++ LL P+ R E L PW Q E
Sbjct: 479 LKDQI---TSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKAR---FTTEEALRHPWLQDE 532
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 84.0 bits (206), Expect = 2e-16
Identities = 85/300 (28%), Positives = 139/300 (46%), Gaps = 26/300 (8%)
Query: 46 MTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLY 105
+T+ Q++ + + Y + LG G G V L R+ +A+K + K + ++ G
Sbjct: 204 LTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAI-GSAR 262
Query: 106 EFCVGLSLGAHSAIVTAYG----IGIES---AHSYSFLTEPVLHGDLMAFIQPKVGLPQP 158
E L++ I+ I I++ A Y + E + G+L + L +
Sbjct: 263 EADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEA 322
Query: 159 AVHRCAAQLASALEYIHARGLVYRDLKPENVLVC--DPACRRFKLTDFGHTRPRG--TLL 214
Q+ A++Y+H G+++RDLKPENVL+ + C K+TDFGH++ G +L+
Sbjct: 323 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLM 381
Query: 215 R-LAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPF 273
R L G P Y APE+ A+D W+LGV+LF L+GY P+ +
Sbjct: 382 RTLCGTP-TYLAPEVLVSVGT---AGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS-- 435
Query: 274 YEDFLIWQASGQPRDRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQRE 333
+D + SG+ P+ W ++ A L++ LL P+ R E L PW Q E
Sbjct: 436 LKDQI---TSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKAR---FTTEEALRHPWLQDE 489
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 84.0 bits (206), Expect = 2e-16
Identities = 78/264 (29%), Positives = 123/264 (46%), Gaps = 23/264 (8%)
Query: 62 YEEVRPLGQGRYGRVLLV----THRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHS 117
++ +R +G+G Y +VLLV T R + K+L + E V H
Sbjct: 254 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 313
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
+V + ++ F+ E V GDLM +Q + LP+ +A+++ AL Y+H R
Sbjct: 314 FLVGLHSC-FQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 372
Query: 178 GLVYRDLKPENVLVCDPACRRFKLTDFG----HTRPRGTLLRLAGPPIPYTAPELCAPPP 233
G++YRDLK +NVL+ KLTD+G RP T G P Y APE+
Sbjct: 373 GIIYRDLKLDNVLLDSEG--HIKLTDYGMCKEGLRPGDTTSTFCGTP-NYIAPEIL---- 425
Query: 234 LPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFY--EDFLIWQASGQPRDRPQ 291
G ++D WALGVL+F ++ G P+D + +P ED+L + P+
Sbjct: 426 --RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 483
Query: 292 PWFGLAPAADALLRGLLDPHPRRR 315
L+ A ++L+ L+ P+ R
Sbjct: 484 ---SLSVKAASVLKSFLNKDPKER 504
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 83.6 bits (205), Expect = 2e-16
Identities = 85/287 (29%), Positives = 129/287 (44%), Gaps = 33/287 (11%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTS----LRGFLYEFCVGLSLGAHS 117
YE + LG+G YG+V G +A+K + K + L E + SL H
Sbjct: 53 YEFLETLGKGTYGKVKKA-RESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLN-HP 110
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
I+ + + E++ + E GDL +I + L + Q+ SA+ Y H
Sbjct: 111 HIIAIHEV-FENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQN 169
Query: 178 GLVYRDLKPENVLVCDPACRRFKLTDFG--HTRPRGTLLR-LAGPPIPYTAPELCAPPPL 234
+V+RDLK EN+L+ A K+ DFG + +G L+ G P+ Y +PE+ P
Sbjct: 170 RVVHRDLKLENILL--DANGNIKIADFGLSNLYHQGKFLQTFCGSPL-YASPEIVNGKPY 226
Query: 235 PEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQAS-GQPRDRPQPW 293
P +D+W+LGVLL+ L+ G P+ D L+ Q S G R+ P+P
Sbjct: 227 -----TGPEVDSWSLGVLLYILVHGTMPF-------DGHDHKILVKQISNGAYREPPKP- 273
Query: 294 FGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPW--RQREGEAEA 338
A L+R LL +P RR+ + + H W R GE EA
Sbjct: 274 ----SDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEA 316
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 83.2 bits (204), Expect = 3e-16
Identities = 93/344 (27%), Positives = 150/344 (43%), Gaps = 35/344 (10%)
Query: 2 PGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLS---AQTLVRAEV 58
PG S +G A E + + L + L++ A + +++S +Q ++
Sbjct: 329 PGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDI 388
Query: 59 DELYEEV--RPLGQGRYGRVLLVTHRQKGTPLALKQLPKPR--TSLRGFLYEFCVGLSLG 114
+Y+ LG G++G V HR+ G +A+K + K R T L L
Sbjct: 389 ATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSL 448
Query: 115 AHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFI--QPKVGLPQPAVHRCAAQLASALE 172
H IV + E+ F+ LHGD++ I K LP+ Q+ AL
Sbjct: 449 RHPGIVNLECM-FETPEKV-FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALR 506
Query: 173 YIHARGLVYRDLKPENVLV--CDPACRRFKLTDFGHTR---PRGTLLRLAGPPIPYTAPE 227
++H + +V+ DLKPENVL+ DP + KL DFG R + + G P Y APE
Sbjct: 507 HLHFKNIVHCDLKPENVLLASADP-FPQVKLCDFGFARIIGEKSFRRSVVGTP-AYLAPE 564
Query: 228 LCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPR 287
+ L +G +LD W++GV+++ L+G FP++ D ++ AS
Sbjct: 565 VL----LNQG--YNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPAS---- 614
Query: 288 DRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQ 331
PW ++ A L+ LL R+R ++ + L PW Q
Sbjct: 615 ----PWSHISAGAIDLINNLLQVKMRKR---YSVDKSLSHPWLQ 651
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 83.2 bits (204), Expect = 3e-16
Identities = 93/344 (27%), Positives = 150/344 (43%), Gaps = 35/344 (10%)
Query: 2 PGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLS---AQTLVRAEV 58
PG S +G A E + + L + L++ A + +++S +Q ++
Sbjct: 486 PGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDI 545
Query: 59 DELYEEV--RPLGQGRYGRVLLVTHRQKGTPLALKQLPKPR--TSLRGFLYEFCVGLSLG 114
+Y+ LG G++G V HR+ G +A+K + K R T L L
Sbjct: 546 ATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSL 605
Query: 115 AHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFI--QPKVGLPQPAVHRCAAQLASALE 172
H IV + E+ F+ LHGD++ I K LP+ Q+ AL
Sbjct: 606 RHPGIVNLECM-FETPEKV-FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALR 663
Query: 173 YIHARGLVYRDLKPENVLV--CDPACRRFKLTDFGHTR---PRGTLLRLAGPPIPYTAPE 227
++H + +V+ DLKPENVL+ DP + KL DFG R + + G P Y APE
Sbjct: 664 HLHFKNIVHCDLKPENVLLASADP-FPQVKLCDFGFARIIGEKSFRRSVVGTP-AYLAPE 721
Query: 228 LCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPR 287
+ L +G +LD W++GV+++ L+G FP++ D ++ AS
Sbjct: 722 VL----LNQG--YNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPAS---- 771
Query: 288 DRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQ 331
PW ++ A L+ LL R+R ++ + L PW Q
Sbjct: 772 ----PWSHISAGAIDLINNLLQVKMRKR---YSVDKSLSHPWLQ 808
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 83.2 bits (204), Expect = 3e-16
Identities = 93/344 (27%), Positives = 150/344 (43%), Gaps = 35/344 (10%)
Query: 2 PGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLS---AQTLVRAEV 58
PG S +G A E + + L + L++ A + +++S +Q ++
Sbjct: 486 PGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDI 545
Query: 59 DELYEEV--RPLGQGRYGRVLLVTHRQKGTPLALKQLPKPR--TSLRGFLYEFCVGLSLG 114
+Y+ LG G++G V HR+ G +A+K + K R T L L
Sbjct: 546 ATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSL 605
Query: 115 AHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFI--QPKVGLPQPAVHRCAAQLASALE 172
H IV + E+ F+ LHGD++ I K LP+ Q+ AL
Sbjct: 606 RHPGIVNLECM-FETPEKV-FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALR 663
Query: 173 YIHARGLVYRDLKPENVLV--CDPACRRFKLTDFGHTR---PRGTLLRLAGPPIPYTAPE 227
++H + +V+ DLKPENVL+ DP + KL DFG R + + G P Y APE
Sbjct: 664 HLHFKNIVHCDLKPENVLLASADP-FPQVKLCDFGFARIIGEKSFRRSVVGTP-AYLAPE 721
Query: 228 LCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPR 287
+ L +G +LD W++GV+++ L+G FP++ D ++ AS
Sbjct: 722 VL----LNQG--YNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPAS---- 771
Query: 288 DRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQ 331
PW ++ A L+ LL R+R ++ + L PW Q
Sbjct: 772 ----PWSHISAGAIDLINNLLQVKMRKR---YSVDKSLSHPWLQ 808
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 83.2 bits (204), Expect = 3e-16
Identities = 93/344 (27%), Positives = 150/344 (43%), Gaps = 35/344 (10%)
Query: 2 PGKQSEEGPAEAGASEDSEEEGLGGLTLEELQQGQEAARALEDMMTLS---AQTLVRAEV 58
PG S +G A E + + L + L++ A + +++S +Q ++
Sbjct: 486 PGGPSGQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDI 545
Query: 59 DELYEEV--RPLGQGRYGRVLLVTHRQKGTPLALKQLPKPR--TSLRGFLYEFCVGLSLG 114
+Y+ LG G++G V HR+ G +A+K + K R T L L
Sbjct: 546 ATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSL 605
Query: 115 AHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFI--QPKVGLPQPAVHRCAAQLASALE 172
H IV + E+ F+ LHGD++ I K LP+ Q+ AL
Sbjct: 606 RHPGIVNLECM-FETPEKV-FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALR 663
Query: 173 YIHARGLVYRDLKPENVLV--CDPACRRFKLTDFGHTR---PRGTLLRLAGPPIPYTAPE 227
++H + +V+ DLKPENVL+ DP + KL DFG R + + G P Y APE
Sbjct: 664 HLHFKNIVHCDLKPENVLLASADP-FPQVKLCDFGFARIIGEKSFRRSVVGTP-AYLAPE 721
Query: 228 LCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPR 287
+ L +G +LD W++GV+++ L+G FP++ D ++ AS
Sbjct: 722 VL----LNQG--YNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPAS---- 771
Query: 288 DRPQPWFGLAPAADALLRGLLDPHPRRRSAVIAIREHLGRPWRQ 331
PW ++ A L+ LL R+R ++ + L PW Q
Sbjct: 772 ----PWSHISAGAIDLINNLLQVKMRKR---YSVDKSLSHPWLQ 808
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 83.2 bits (204), Expect = 3e-16
Identities = 79/264 (29%), Positives = 116/264 (43%), Gaps = 31/264 (11%)
Query: 60 ELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTS---LRGFLYEFCVGLSLGAH 116
E Y + +G+G +GRV + +ALK +PK S LR E + L H
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGL-RH 60
Query: 117 SAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHA 176
IV E+ +T+ G+L ++ LP+ V AAQL SAL Y+H+
Sbjct: 61 PNIVHMLD-SFETDKEVVVVTD-YAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118
Query: 177 RGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRGT----LLRLAGPPIPYTAPELCAPP 232
+++RD+KP+N+L+ KL DFG R T L + G P+ Y +PEL
Sbjct: 119 HRILHRDMKPQNILLAKGG--GIKLCDFGFARAMSTNTMVLTSIKGTPL-YMSPELV--- 172
Query: 233 PLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQP 292
E P D W++G +L+ L G PFY + S +D P
Sbjct: 173 ---EERPYDHTADLWSVGCILYELAVG----------TPPFYATSIFQLVSLILKD-PVR 218
Query: 293 W-FGLAPAADALLRGLLDPHPRRR 315
W ++P L+GLL PR+R
Sbjct: 219 WPSTISPCFKNFLQGLLTKDPRQR 242
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 82.4 bits (202), Expect = 5e-16
Identities = 78/263 (29%), Positives = 118/263 (44%), Gaps = 30/263 (11%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKP----RTSLRGFLYEFCVGLSLGAHS 117
++ ++ +G+G YG+VLL + G A+K L K + + E V L H
Sbjct: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
+V ++ F+ + V G+L +Q + +P AA++ASA+ Y+H+
Sbjct: 95 FLV-GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
Query: 178 GLVYRDLKPENVLVCDPACR-RFKLTDFG----HTRPRGTLLRLAGPPIPYTAPELCAPP 232
++YRDLKPEN+L+ C+ LTDFG P T G P Y APE+
Sbjct: 154 NIIYRDLKPENILL---DCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP-EYLAPEVLRKE 209
Query: 233 PLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQP 292
P A+D W LG +L+ +L G P+ + YE+ L QP P
Sbjct: 210 PYDR------AVDWWCLGAVLYEMLHGLPPFYS--QDVSQMYENIL-----HQPLQIPG- 255
Query: 293 WFGLAPAADALLRGLLDPHPRRR 315
G AA LL+ LL R+R
Sbjct: 256 --GRTVAACDLLQSLLHKDQRQR 276
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 82.4 bits (202), Expect = 5e-16
Identities = 78/263 (29%), Positives = 118/263 (44%), Gaps = 30/263 (11%)
Query: 62 YEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKP----RTSLRGFLYEFCVGLSLGAHS 117
++ ++ +G+G YG+VLL + G A+K L K + + E V L H
Sbjct: 95 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 154
Query: 118 AIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR 177
+V ++ F+ + V G+L +Q + +P AA++ASA+ Y+H+
Sbjct: 155 FLV-GLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
Query: 178 GLVYRDLKPENVLVCDPACR-RFKLTDFG----HTRPRGTLLRLAGPPIPYTAPELCAPP 232
++YRDLKPEN+L+ C+ LTDFG P T G P Y APE+
Sbjct: 214 NIIYRDLKPENILL---DCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP-EYLAPEVLRKE 269
Query: 233 PLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQP 292
P A+D W LG +L+ +L G P+ + YE+ L QP P
Sbjct: 270 PYDR------AVDWWCLGAVLYEMLHGLPPFYS--QDVSQMYENIL-----HQPLQIPG- 315
Query: 293 WFGLAPAADALLRGLLDPHPRRR 315
G AA LL+ LL R+R
Sbjct: 316 --GRTVAACDLLQSLLHKDQRQR 336
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 82.4 bits (202), Expect = 5e-16
Identities = 78/279 (27%), Positives = 123/279 (44%), Gaps = 22/279 (7%)
Query: 68 LGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSL-GAHSAIVTAYGIG 126
LGQG + RQ G A+K L + L L L +H +V + +
Sbjct: 411 LGQGSFSVCRRCRQRQSGQEFAVKILSR---RLEANTQREVAALRLCQSHPNVVNLHEVH 467
Query: 127 IESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALEYIHAR-GLVYRDLK 185
+ H+Y L E + G+L+ I+ K + + L SA+ ++H G+V+RDLK
Sbjct: 468 HDQLHTYLVL-ELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLK 526
Query: 186 PENVLVCDPA-CRRFKLTDFGHTRPR----GTLLRLAGPPIPYTAPELCAPPPLPEGLPI 240
PEN+L D K+ DFG R R G ++ + Y APEL A E
Sbjct: 527 PENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDE---- 582
Query: 241 QPALDAWALGVLLFCLLTGYFPWDRPLAEADPFY-EDFLIWQASGQPRDRPQPWFGLAPA 299
+ D W+LGV+L+ +L+G P+ + + + G+ + W G++
Sbjct: 583 --SCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEE 640
Query: 300 ADALLRGLLDPHPRRRSAVIAIREHLGRPWRQREGEAEA 338
A L+RGLL P +R + +R G W Q +G A +
Sbjct: 641 AKELVRGLLTVDPAKRLKLEGLR---GSSWLQ-DGSARS 675
Score = 64.3 bits (155), Expect = 2e-10
Identities = 61/216 (28%), Positives = 91/216 (42%), Gaps = 20/216 (9%)
Query: 60 ELYEEVRPLGQGRYGRVLLVTH---RQKGTPLALKQLPKPRTSLRGFLYEFCVG----LS 112
E +E ++ LG G YG+V LV G A+K L K R E L
Sbjct: 31 ENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLE 90
Query: 113 LGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHRCAAQLASALE 172
L + + ++ + + V G++ + + + V ++ ALE
Sbjct: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
Query: 173 YIHARGLVYRDLKPENVLVCDPACRRFKLTDFG-----HTRPRGTLLRLAGPPIPYTAPE 227
++H G++YRDLK ENVL+ LTDFG T + G I Y APE
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSEG--HIVLTDFGLSKEFLTEEKERTFSFCG-TIEYMAPE 207
Query: 228 LCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPW 263
+ + A+D W+LG+LLF LLTG P+
Sbjct: 208 I-----IRSKTGHGKAVDWWSLGILLFELLTGASPF 238
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,869,301
Number of Sequences: 37866
Number of extensions: 865880
Number of successful extensions: 5209
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 565
Number of HSP's successfully gapped in prelim test: 190
Number of HSP's that attempted gapping in prelim test: 3695
Number of HSP's gapped (non-prelim): 999
length of query: 348
length of database: 18,247,518
effective HSP length: 103
effective length of query: 245
effective length of database: 14,347,320
effective search space: 3515093400
effective search space used: 3515093400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.