Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 110349794
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110349794 homer 2 isoform 3 [Homo sapiens]
(288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110349794 homer 2 isoform 3 [Homo sapiens] 565 e-161
gi|110349797 homer 2 isoform 4 [Homo sapiens] 556 e-159
gi|46249349 homer 2 isoform 1 [Homo sapiens] 530 e-151
gi|46249351 homer 2 isoform 2 [Homo sapiens] 517 e-147
gi|4759198 homer 1 [Homo sapiens] 288 4e-78
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [... 237 8e-63
gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1 [... 236 2e-62
gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1 [... 236 2e-62
gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3 [... 201 6e-52
gi|56549694 enabled homolog isoform a [Homo sapiens] 70 3e-12
gi|39930375 enabled homolog isoform b [Homo sapiens] 70 3e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 56 4e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 56 4e-08
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 53 4e-07
gi|7706687 Enah/Vasp-like [Homo sapiens] 53 4e-07
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens] 52 6e-07
gi|32698688 citron [Homo sapiens] 52 6e-07
gi|55770834 centromere protein F [Homo sapiens] 51 1e-06
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 50 2e-06
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 50 2e-06
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 50 2e-06
gi|16262452 cingulin [Homo sapiens] 50 3e-06
gi|58530840 desmoplakin isoform I [Homo sapiens] 49 4e-06
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 49 5e-06
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 49 5e-06
gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 49 5e-06
gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 49 7e-06
gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 49 7e-06
gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens] 49 7e-06
gi|38044112 restin isoform b [Homo sapiens] 49 7e-06
>gi|110349794 homer 2 isoform 3 [Homo sapiens]
Length = 288
Score = 565 bits (1456), Expect = e-161
Identities = 288/288 (100%), Positives = 288/288 (100%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKN 180
IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKN
Sbjct: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKN 180
Query: 181 TQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVR 240
TQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVR
Sbjct: 181 TQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVR 240
Query: 241 SLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
SLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 241 SLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
>gi|110349797 homer 2 isoform 4 [Homo sapiens]
Length = 299
Score = 556 bits (1434), Expect = e-159
Identities = 288/299 (96%), Positives = 288/299 (96%), Gaps = 11/299 (3%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQ-----------ASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 169
IETSSNHSQ ASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
Query: 170 KNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAE 229
KNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAE
Sbjct: 181 KNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAE 240
Query: 230 RDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
RDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 241 RDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 299
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 530 bits (1365), Expect = e-151
Identities = 285/343 (83%), Positives = 288/343 (83%), Gaps = 55/343 (16%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQS--------------- 165
IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQS
Sbjct: 121 IETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLR 180
Query: 166 -------------AANVK---------------------------NEINREKEKNTQLKR 185
AA+V+ +EINREKEKNTQLKR
Sbjct: 181 ESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKR 240
Query: 186 RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 245
RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD
Sbjct: 241 RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 300
Query: 246 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 301 IEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 343
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 517 bits (1331), Expect = e-147
Identities = 283/354 (79%), Positives = 286/354 (80%), Gaps = 66/354 (18%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST
Sbjct: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
Query: 121 IETSSNHS-----------QASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 169
IETSSNHS QASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV
Sbjct: 121 IETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANV 180
Query: 170 K---------------------------------------------NEINREKE------ 178
K N+I+ +E
Sbjct: 181 KKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEIN 240
Query: 179 ----KNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 234
KNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN
Sbjct: 241 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 300
Query: 235 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
Sbjct: 301 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 354
>gi|4759198 homer 1 [Homo sapiens]
Length = 354
Score = 288 bits (737), Expect = 4e-78
Identities = 166/350 (47%), Positives = 216/350 (61%), Gaps = 66/350 (18%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINST 60
MGEQPIF+TRAHVFQIDPNTKKNW+P SK AVTVSYFYD TRN YRIIS+DG+K IINST
Sbjct: 1 MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST 60
Query: 61 ITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEK 120
ITPNMTFTKTSQKFGQWADSRANTV+GLGFSSE L+KFAEKFQE KEAA++AK+K+QEK
Sbjct: 61 ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK 120
Query: 121 IETSSNHSQAS------------SVNGTDDEKA--------------------SHAGPAN 148
+E +S SQ S S+NGTDDE+ SH+ +
Sbjct: 121 MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAIS 180
Query: 149 TH-------LKSENDKLKIALTQSAANVK---------------------------NEIN 174
H LK N KL AL +S ANVK ++ N
Sbjct: 181 KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN 240
Query: 175 REKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN 234
T+L + I+ELE L+ KE E++ L+++ + +L + + +++KL+ E N++
Sbjct: 241 AVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD 300
Query: 235 LEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284
LE ++ L+ +E+S+ Q + LK+ LE+LDGKI +L + R L+KL
Sbjct: 301 LEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKL 350
>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
Length = 358
Score = 237 bits (605), Expect = 8e-63
Identities = 145/348 (41%), Positives = 204/348 (58%), Gaps = 66/348 (18%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSS------NH----SQASSVNGTDDEK------ASHAGPANTH---------------- 150
+S +H S S NG +EK A GP
Sbjct: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
Query: 151 ------LKSENDKLKIALTQS---AANVKNEINREKEKNTQLKRRIEELEAELREKETEL 201
L+ N+KL AL ++ AA + ++ ++ + +L++R+ ELEA+ + T
Sbjct: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
Query: 202 KD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD---------NQNLE 236
+ ++ + + I L S+ E LEAAER+ N LE
Sbjct: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQTRNAELE 305
Query: 237 DKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284
++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 306 HQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 353
>gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 236 bits (602), Expect = 2e-62
Identities = 145/351 (41%), Positives = 204/351 (58%), Gaps = 69/351 (19%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSS------NH----SQASSVNGTDDEK------ASHAGPANTH---------------- 150
+S +H S S NG +EK A GP
Sbjct: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
Query: 151 ------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETEL 201
L+ N+KL AL + +AA + ++ ++ + +L++R+ ELEA+ + T
Sbjct: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
Query: 202 KD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD------------NQ 233
+ ++ + + I L S+ E LEAAER+ N
Sbjct: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
Query: 234 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
>gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 236 bits (602), Expect = 2e-62
Identities = 145/351 (41%), Positives = 204/351 (58%), Gaps = 69/351 (19%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
Query: 123 TSS------NH----SQASSVNGTDDEK------ASHAGPANTH---------------- 150
+S +H S S NG +EK A GP
Sbjct: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
Query: 151 ------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETEL 201
L+ N+KL AL + +AA + ++ ++ + +L++R+ ELEA+ + T
Sbjct: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
Query: 202 KD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD------------NQ 233
+ ++ + + I L S+ E LEAAER+ N
Sbjct: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
Query: 234 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
>gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3
[Homo sapiens]
Length = 325
Score = 201 bits (511), Expect = 6e-52
Identities = 125/321 (38%), Positives = 178/321 (55%), Gaps = 45/321 (14%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
Query: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT Q A +EK+
Sbjct: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLT------QVPPSPLVSANGPGEEKLF 119
Query: 123 TSSNHSQASSVNGTDDEKASHAGPANT--------HLKSENDKLKIALTQ---SAANVKN 171
S + +K G L+ N+KL AL + +AA +
Sbjct: 120 RSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ 179
Query: 172 EINREKEKNTQLKRRIEELEAELREKETELKD----------------LRKQSEIIPQLM 215
++ ++ + +L++R+ ELEA+ + T + ++ + + I L
Sbjct: 180 QLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK 239
Query: 216 SECEYVSEKLEAAERD------------NQNLEDKVRSLKTDIEESKYRQRHLKVELKSF 263
S+ E LEAAER+ N LE ++R+++ +EE++ + + E+
Sbjct: 240 SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRA 299
Query: 264 LEVLDGKIDDLHDFRRGLSKL 284
++LD + +L + R GL++L
Sbjct: 300 AQLLDVSLFELSELREGLARL 320
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 69.7 bits (169), Expect = 3e-12
Identities = 65/270 (24%), Positives = 117/270 (43%), Gaps = 27/270 (10%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPA--SKQAVTVSYFYDVTRNSYRIIS--VDGAKVI 56
M EQ I RA V D KK W+PA S V ++ N++R++ + +V+
Sbjct: 1 MSEQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVV 59
Query: 57 INSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDK 116
IN I + + + +Q F QW D+R V+GL F S++ FA E + +
Sbjct: 60 INCAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEV--LNSQE 115
Query: 117 TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINRE 176
T + ++ A N GP+ L+ + +L+ Q + + RE
Sbjct: 116 TGPTLPRQNSQLPAQVQN----------GPSQEELEIQRRQLQEQQRQKELE-RERLERE 164
Query: 177 KEKNTQLKR------RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAER 230
+ + +L+R R+E E + E E ++ +Q + Q E + E+ E +R
Sbjct: 165 RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
Query: 231 DNQNLEDKVRSLKTDIE-ESKYRQRHLKVE 259
+ Q +++ R + + E + + RQ L+ E
Sbjct: 225 ERQERQERERLERLERERQERERQEQLERE 254
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 69.7 bits (169), Expect = 3e-12
Identities = 65/270 (24%), Positives = 117/270 (43%), Gaps = 27/270 (10%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPA--SKQAVTVSYFYDVTRNSYRIIS--VDGAKVI 56
M EQ I RA V D KK W+PA S V ++ N++R++ + +V+
Sbjct: 1 MSEQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVV 59
Query: 57 INSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDK 116
IN I + + + +Q F QW D+R V+GL F S++ FA E + +
Sbjct: 60 INCAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEV--LNSQE 115
Query: 117 TQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINRE 176
T + ++ A N GP+ L+ + +L+ Q + + RE
Sbjct: 116 TGPTLPRQNSQLPAQVQN----------GPSQEELEIQRRQLQEQQRQKELE-RERLERE 164
Query: 177 KEKNTQLKR------RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAER 230
+ + +L+R R+E E + E E ++ +Q + Q E + E+ E +R
Sbjct: 165 RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDR 224
Query: 231 DNQNLEDKVRSLKTDIE-ESKYRQRHLKVE 259
+ Q +++ R + + E + + RQ L+ E
Sbjct: 225 ERQERQERERLERLERERQERERQEQLERE 254
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/145 (26%), Positives = 79/145 (54%), Gaps = 9/145 (6%)
Query: 148 NTHLKSENDKLKIALTQSAANVKNEINREKE------KNTQLKRRIEELEAELREKETEL 201
N L+SE ++LK L A+ K E +N +L++ +E ++++ E+EL
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK--VE 259
+DL +++ + + + E + S++LE E++N++LE + L+ D ++ + + L+ E
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 260 LK-SFLEVLDGKIDDLHDFRRGLSK 283
+K + LE + KI +L + LSK
Sbjct: 847 IKDTTLEENNVKIGNLEKENKTLSK 871
Score = 46.2 bits (108), Expect = 3e-05
Identities = 45/215 (20%), Positives = 100/215 (46%), Gaps = 26/215 (12%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVN-GTDDEKASHAGPANTHL 151
++Q+ K E ++E E A+ +++ +E + Q N EK N+ L
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHH-LEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 152 KSENDKLKIAL------TQSAANVKNEINREKEKNTQLKRRIE----------ELEAELR 195
+ EN KLK L T +++ E ++ E+N +L+R +E +L+ E +
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK 728
Query: 196 EKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLE-------DKVRSLKTDIEE 248
E E+E + L+K E++ + E + + + +NQ L+ K++ L++++++
Sbjct: 729 ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD 788
Query: 249 SKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSK 283
+ + L+ L+ L++ +++ L + L +
Sbjct: 789 LEMENQTLQKNLEE-LKISSKRLEQLEKENKSLEQ 822
Score = 38.9 bits (89), Expect = 0.005
Identities = 33/189 (17%), Positives = 79/189 (41%), Gaps = 38/189 (20%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQASSVN------GTDDEKASHAGPANTHLKSENDKL 158
++K + +D EK++T ++ + G + E+ H +++ +
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH-----DEQSTDDSRY 954
Query: 159 KIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC 218
K+ ++ + +K + ++EK L+ R+EE ++ ELK ++K E + Q E
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Query: 219 EY---------------------------VSEKLEAAERDNQNLEDKVRSLKTDIEESKY 251
V ++L ER+N L+ + ++LKT +++ +
Sbjct: 1015 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1074
Query: 252 RQRHLKVEL 260
+ +L+ ++
Sbjct: 1075 QNNNLQAQI 1083
Score = 36.2 bits (82), Expect = 0.034
Identities = 45/197 (22%), Positives = 83/197 (42%), Gaps = 36/197 (18%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH--- 150
+QL K + ++ E +++ KDK Q + E QA + T +E G
Sbjct: 811 EQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 151 -----------------LKSENDKLKIALT---QSAANVKNEINREKEKNTQLKRRIEEL 190
L+ EN +L T ++ ++ ++ EK K Q+ +E+L
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 191 EAELRE----KETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNL-EDKVRSLKTD 245
EL + KE L D + + S + + KLE+ + + + E+K+ +L+
Sbjct: 929 THELEKIGLNKERLLHDEQSTDD------SRYKLLESKLESTLKKSLEIKEEKIAALEAR 982
Query: 246 IEESKYRQRHLKVELKS 262
+EES + L+ ELK+
Sbjct: 983 LEESTNYNQQLRQELKT 999
Score = 33.5 bits (75), Expect = 0.22
Identities = 39/186 (20%), Positives = 80/186 (43%), Gaps = 9/186 (4%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSV--NGTDDEKASHAGPANTH- 150
Q LTK E+ + ++ + K + + + S+ + N EK S N
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 151 -LKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELR-EKETELKDLRKQS 208
L E +L+ + N + +I +++N L + + L + E +KD+ K++
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 209 EIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 268
+I+ + + E S KL E + + ++ ++ K E ++ + L L+ E+L
Sbjct: 590 KILHESIKE---TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQ 645
Query: 269 GKIDDL 274
KI +L
Sbjct: 646 KKITNL 651
Score = 31.6 bits (70), Expect = 0.84
Identities = 28/118 (23%), Positives = 54/118 (45%), Gaps = 9/118 (7%)
Query: 164 QSAANVKNEINREKEKNTQL-------KRRIEELEAELREKETELKDLRKQSEIIPQLMS 216
Q ++ E+ R +++N L + +EL+A LREK + L + + +
Sbjct: 279 QELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKLESEVSRYKERLH 337
Query: 217 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 274
+ E+ ++E + DNQ L + L+ +E ++ R L K L+ L K+ D+
Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDM 394
Score = 30.4 bits (67), Expect = 1.9
Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 13/104 (12%)
Query: 163 TQSAANVKNEINREKEKNTQLKRRIEE-------LEAELREKETELKDLRKQSEIIPQLM 215
T+S ++ E+ K K +L++ +EE + EL + E ELK L++++ +
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 216 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE 259
++L+A E VR K + E S+Y++R +E
Sbjct: 303 RSARMYRDELDALR------EKAVRVDKLESEVSRYKERLHDIE 340
Score = 30.4 bits (67), Expect = 1.9
Identities = 41/193 (21%), Positives = 82/193 (42%), Gaps = 18/193 (9%)
Query: 93 EQQLTKFAEKFQEV---KEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANT 149
E +++++ E+ ++ K + K+ Q +ET + +K N
Sbjct: 326 ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENL 385
Query: 150 HLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 209
LK++ +++ + +I E+N L+ ++ E EL+ + + SE
Sbjct: 386 QLKAKLHDMEMERDMD----RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 210 I--IPQ--LMSEC-EYVSEKLEAAERDNQNLEDKVRSLKTDIEESK-YRQRHLKVE---- 259
+ PQ L E E S +L E +NQ+L V L+T ++ + + LK+E
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501
Query: 260 -LKSFLEVLDGKI 271
L +E+L+ +I
Sbjct: 502 RLSKKVEILENEI 514
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/145 (26%), Positives = 79/145 (54%), Gaps = 9/145 (6%)
Query: 148 NTHLKSENDKLKIALTQSAANVKNEINREKE------KNTQLKRRIEELEAELREKETEL 201
N L+SE ++LK L A+ K E +N +L++ +E ++++ E+EL
Sbjct: 727 NKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL 786
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK--VE 259
+DL +++ + + + E + S++LE E++N++LE + L+ D ++ + + L+ E
Sbjct: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 260 LK-SFLEVLDGKIDDLHDFRRGLSK 283
+K + LE + KI +L + LSK
Sbjct: 847 IKDTTLEENNVKIGNLEKENKTLSK 871
Score = 46.2 bits (108), Expect = 3e-05
Identities = 45/215 (20%), Positives = 100/215 (46%), Gaps = 26/215 (12%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVN-GTDDEKASHAGPANTHL 151
++Q+ K E ++E E A+ +++ +E + Q N EK N+ L
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHH-LEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 152 KSENDKLKIAL------TQSAANVKNEINREKEKNTQLKRRIE----------ELEAELR 195
+ EN KLK L T +++ E ++ E+N +L+R +E +L+ E +
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK 728
Query: 196 EKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLE-------DKVRSLKTDIEE 248
E E+E + L+K E++ + E + + + +NQ L+ K++ L++++++
Sbjct: 729 ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD 788
Query: 249 SKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSK 283
+ + L+ L+ L++ +++ L + L +
Sbjct: 789 LEMENQTLQKNLEE-LKISSKRLEQLEKENKSLEQ 822
Score = 40.8 bits (94), Expect = 0.001
Identities = 35/189 (18%), Positives = 80/189 (42%), Gaps = 39/189 (20%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQASSVN------GTDDEKASHAGPANTHLKSENDKL 158
++K + +D EK++T ++ + G + E+ H +S +D+
Sbjct: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE------QSTDDRY 953
Query: 159 KIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSEC 218
K+ ++ + +K + ++EK L+ R+EE ++ ELK ++K E + Q E
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1013
Query: 219 EY---------------------------VSEKLEAAERDNQNLEDKVRSLKTDIEESKY 251
V ++L ER+N L+ + ++LKT +++ +
Sbjct: 1014 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLET 1073
Query: 252 RQRHLKVEL 260
+ +L+ ++
Sbjct: 1074 QNNNLQAQI 1082
Score = 34.7 bits (78), Expect = 0.100
Identities = 44/195 (22%), Positives = 83/195 (42%), Gaps = 33/195 (16%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTH--- 150
+QL K + ++ E +++ KDK Q + E QA + T +E G
Sbjct: 811 EQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 151 -----------------LKSENDKLKIALT---QSAANVKNEINREKEKNTQLKRRIEEL 190
L+ EN +L T ++ ++ ++ EK K Q+ +E+L
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 191 EAELREKETELKDLRKQSEIIPQLMSECEY--VSEKLEAAERDNQNL-EDKVRSLKTDIE 247
EL E L K+ + + ++ Y + KLE+ + + + E+K+ +L+ +E
Sbjct: 929 THEL-----EKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLE 983
Query: 248 ESKYRQRHLKVELKS 262
ES + L+ ELK+
Sbjct: 984 ESTNYNQQLRQELKT 998
Score = 33.5 bits (75), Expect = 0.22
Identities = 39/186 (20%), Positives = 80/186 (43%), Gaps = 9/186 (4%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSV--NGTDDEKASHAGPANTH- 150
Q LTK E+ + ++ + K + + + S+ + N EK S N
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 151 -LKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELR-EKETELKDLRKQS 208
L E +L+ + N + +I +++N L + + L + E +KD+ K++
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 209 EIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLD 268
+I+ + + E S KL E + + ++ ++ K E ++ + L L+ E+L
Sbjct: 590 KILHESIKE---TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQ 645
Query: 269 GKIDDL 274
KI +L
Sbjct: 646 KKITNL 651
Score = 31.6 bits (70), Expect = 0.84
Identities = 28/118 (23%), Positives = 54/118 (45%), Gaps = 9/118 (7%)
Query: 164 QSAANVKNEINREKEKNTQL-------KRRIEELEAELREKETELKDLRKQSEIIPQLMS 216
Q ++ E+ R +++N L + +EL+A LREK + L + + +
Sbjct: 279 QELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKLESEVSRYKERLH 337
Query: 217 ECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 274
+ E+ ++E + DNQ L + L+ +E ++ R L K L+ L K+ D+
Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDM 394
Score = 30.4 bits (67), Expect = 1.9
Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 13/104 (12%)
Query: 163 TQSAANVKNEINREKEKNTQLKRRIEE-------LEAELREKETELKDLRKQSEIIPQLM 215
T+S ++ E+ K K +L++ +EE + EL + E ELK L++++ +
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 216 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE 259
++L+A E VR K + E S+Y++R +E
Sbjct: 303 RSARMYRDELDALR------EKAVRVDKLESEVSRYKERLHDIE 340
Score = 30.4 bits (67), Expect = 1.9
Identities = 41/193 (21%), Positives = 82/193 (42%), Gaps = 18/193 (9%)
Query: 93 EQQLTKFAEKFQEV---KEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANT 149
E +++++ E+ ++ K + K+ Q +ET + +K N
Sbjct: 326 ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENL 385
Query: 150 HLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 209
LK++ +++ + +I E+N L+ ++ E EL+ + + SE
Sbjct: 386 QLKAKLHDMEMERDMD----RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE 441
Query: 210 I--IPQ--LMSEC-EYVSEKLEAAERDNQNLEDKVRSLKTDIEESK-YRQRHLKVE---- 259
+ PQ L E E S +L E +NQ+L V L+T ++ + + LK+E
Sbjct: 442 LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501
Query: 260 -LKSFLEVLDGKI 271
L +E+L+ +I
Sbjct: 502 RLSKKVEILENEI 514
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/188 (24%), Positives = 85/188 (45%), Gaps = 29/188 (15%)
Query: 91 SSEQQLTKFAEKFQEVKE--------AAKIAKDKTQEKIETSSNHSQASSVNGTDDEKAS 142
S Q K E + +K+ A K+A+++ +K + D+E A+
Sbjct: 622 SQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETAT 681
Query: 143 HAGPANTHLKSEND-----------KLKIALTQSAANVKNEINREKEKNTQLKRRIEELE 191
T LK E D L+ T+ N++ + K++ ++ + I L+
Sbjct: 682 II----TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLK 737
Query: 192 AELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKY 251
AE E++ K R Q E +L S+C+ ++E+L E +N+ L+ K + LK +EE
Sbjct: 738 AESLEEKNMAKIHRGQLE---KLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEE--- 791
Query: 252 RQRHLKVE 259
R++H+ +E
Sbjct: 792 REKHISIE 799
Score = 37.4 bits (85), Expect = 0.015
Identities = 40/177 (22%), Positives = 72/177 (40%), Gaps = 27/177 (15%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKD---KTQEKI-ETSSNHSQASSVNGTDDEKASHAGPA 147
+E+ L++ + +EA K +D K QE I + H + E
Sbjct: 458 AERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGK 517
Query: 148 NTHLKSENDKLKIALTQSAANVKN-----------------EINREKEKNTQLKRRIEEL 190
N + E D+LK L + ++N E++ ++EK +K +L
Sbjct: 518 NNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADL 577
Query: 191 EAELREKETEL----KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLK 243
E E++ + +L+KQS+I Q+ E ++ E E AE +DK + L+
Sbjct: 578 ELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEE--EIAELKKSQAQDKAKLLE 632
Score = 33.9 bits (76), Expect = 0.17
Identities = 34/162 (20%), Positives = 74/162 (45%), Gaps = 7/162 (4%)
Query: 118 QEKIETSSNHSQASSVNGTDDEKASHAGPANTHL--KSENDKLKIALTQSAANVKNEINR 175
QE + + H S+ E+ N L +S +D + NE +
Sbjct: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
Query: 176 EKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNL 235
++ + +++RR++ELE E+R E EL + R+Q ++ + E + ++ A+ +
Sbjct: 213 QEVVSDRVERRLQELEREMR-TERELVE-RRQDQLGLMSLQLQEALKKQEAKADEHEGAI 270
Query: 236 EDKVRSLKTD---IEESKYRQRHLKVELKSFLEVLDGKIDDL 274
++K+R +T+ +E+ R L + + E L ++++L
Sbjct: 271 KNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEEL 312
Score = 33.9 bits (76), Expect = 0.17
Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 12/128 (9%)
Query: 159 KIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETEL----KDLRKQSEIIPQL 214
K L +K NREK QL ++L KE+EL + + +Q +++ ++
Sbjct: 871 KTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEI 930
Query: 215 MSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 274
E + E+ + + + +L+D+V +L+T + + L+S E L ++D
Sbjct: 931 HREKRDLLEETQRKDEEMGSLQDRVIALETSTQVA-------LDHLESVPEKL-SLLEDF 982
Query: 275 HDFRRGLS 282
DFR S
Sbjct: 983 KDFRDSCS 990
Score = 33.1 bits (74), Expect = 0.29
Identities = 31/161 (19%), Positives = 75/161 (46%), Gaps = 11/161 (6%)
Query: 105 EVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASH----AGPANTHLKSENDKLKI 160
++ E + A+D T++ S Q+ ++ +++ A + K ++ KL+
Sbjct: 443 QISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLER 502
Query: 161 ALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEY 220
AL + + V KN Q+ + +EL+ +L ++++LRK+ + ++++
Sbjct: 503 ALEKQSETVDELTG----KNNQILKEKDELKTQLYAALQQIENLRKE---LNDVLTKRAL 555
Query: 221 VSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 261
E+L + E ++++ L+ +++ S L+ ELK
Sbjct: 556 QEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELK 596
Score = 32.0 bits (71), Expect = 0.65
Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 97 TKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEND 156
TK + QE+ + K K + + I T +A S+ + K H G LKS+ D
Sbjct: 709 TKHEQNIQELMKHFKKEKSEAENHIRTL----KAESLEEKNMAKI-HRGQLEK-LKSQCD 762
Query: 157 KLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRK 206
+L LTQ+ +NE + K K LK ++EE E + +E L+ + +
Sbjct: 763 RLTEELTQN----ENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEE 808
>gi|7706687 Enah/Vasp-like [Homo sapiens]
Length = 418
Score = 52.8 bits (125), Expect = 4e-07
Identities = 31/103 (30%), Positives = 58/103 (56%), Gaps = 8/103 (7%)
Query: 3 EQPIFTTRAHVFQIDPNTKKNWMPAS--KQAVT-VSYFYDVTRNSYRIISV--DGAKVII 57
EQ I RA V D +T K W+P +Q + ++ +++ N++R++ V +V+I
Sbjct: 5 EQSICQARASVMVYD-DTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVI 63
Query: 58 NSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFA 100
N +I + + + + F QW D+R V+GL F+S+++ T F+
Sbjct: 64 NYSIVKGLKYNQATPTFHQWRDAR--QVYGLNFASKEEATTFS 104
>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
Length = 380
Score = 52.0 bits (123), Expect = 6e-07
Identities = 36/115 (31%), Positives = 58/115 (50%), Gaps = 9/115 (7%)
Query: 1 MGEQPIFTTRAHVFQIDPNTKKNWMPASK--QAVT-VSYFYDVTRNSYRIIS---VDGAK 54
M E I ++RA V D K+ W+PA QA + V +++ T NS+R++ +
Sbjct: 1 MSETVICSSRATVMLYDDGNKR-WLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQ 59
Query: 55 VIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEA 109
V+IN I + + + + F QW D+R V+GL F S++ +FA EA
Sbjct: 60 VVINCAIVRGVKYNQATPNFHQWRDAR--QVWGLNFGSKEDAAQFAAGMASALEA 112
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 52.0 bits (123), Expect = 6e-07
Identities = 36/137 (26%), Positives = 68/137 (49%), Gaps = 8/137 (5%)
Query: 126 NHSQASSVNGTDDEKASHA-GPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLK 184
++S+A + G + S PA T S +K + ++ + +++ ++ +++ T+L
Sbjct: 420 SYSKALGILGRSESVVSGLDSPAKT---SSMEKKLLIKSKELQDSQDKCHKMEQEMTRLH 476
Query: 185 RRIEELEAELREKETELKDLRKQSEIIPQ----LMSECEYVSEKLEAAERDNQNLEDKVR 240
RR+ E+EA L +KE ELK Q ++ Q ++EC + LE A + +DK
Sbjct: 477 RRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKAL 536
Query: 241 SLKTDIEESKYRQRHLK 257
L DI E + + +K
Sbjct: 537 QLLHDIREQSRKLQEIK 553
Score = 39.3 bits (90), Expect = 0.004
Identities = 42/203 (20%), Positives = 88/203 (43%), Gaps = 20/203 (9%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
+ ++ ++ E+ EA K+A + + + T N + ++ + L+
Sbjct: 771 DSKIRSLEQRIVELSEANKLAANSS---LFTQRNMKAQEEMISELRQQKFYLETQAGKLE 827
Query: 153 SENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIP 212
++N KL+ L + + ++ + +K + +L+ R+ E+ E E++ ELK R+ +E+
Sbjct: 828 AQNRKLEEQLEK----ISHQDHSDKNRLLELETRLREVSLEHEEQKLELK--RQLTELQL 881
Query: 213 QLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKID 272
L +L A + LE ++R KT++EE+ L + + + K D
Sbjct: 882 SLQER----ESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFD 937
Query: 273 DLH-------DFRRGLSKLGTDN 288
L D L++L DN
Sbjct: 938 ALRNSCTVITDLEEQLNQLTEDN 960
Score = 34.3 bits (77), Expect = 0.13
Identities = 33/149 (22%), Positives = 66/149 (44%), Gaps = 14/149 (9%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
++ +L + + +E +A +D+ Q K + N + +V +E+ + N L
Sbjct: 907 AKTELEETTAEAEEEIQALTAHRDEIQRKFDALRN---SCTVITDLEEQLNQLTEDNAEL 963
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII 211
++N L L + A+ +EI QL+ ++ L E+ E+E + L Q + +
Sbjct: 964 NNQNFYLSKQLDE-ASGANDEI-------VQLRSEVDHLRREITEREMQ---LTSQKQTM 1012
Query: 212 PQLMSECEYVSEKLEAAERDNQNLEDKVR 240
L + C + E++ E N L +K R
Sbjct: 1013 EALKTTCTMLEEQVMDLEALNDELLEKER 1041
Score = 34.3 bits (77), Expect = 0.13
Identities = 28/113 (24%), Positives = 54/113 (47%), Gaps = 3/113 (2%)
Query: 173 INREKEKNTQLKRRIEELE--AELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAER 230
++ EK+ + +RI E EL KE + + L Q + Q + + E +S+KL E+
Sbjct: 1068 LDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKL-KAESLSDKLNDLEK 1126
Query: 231 DNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSK 283
+ LE RSL+ +E + ++ L E + +D + + + +GL +
Sbjct: 1127 KHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE 1179
Score = 33.9 bits (76), Expect = 0.17
Identities = 33/166 (19%), Positives = 73/166 (43%), Gaps = 12/166 (7%)
Query: 101 EKFQEVKEAAKIAKD--KTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKL 158
+KF +A K+ K +E++E S+ + D + + E+++
Sbjct: 815 QKFYLETQAGKLEAQNRKLEEQLEKISHQDHS------DKNRLLELETRLREVSLEHEEQ 868
Query: 159 KIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQS-EIIPQLMSE 217
K+ L + ++ + + + T L+ LE++LR+ +TEL++ ++ E I L +
Sbjct: 869 KLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 928
Query: 218 CEYVSEKLEAAERD---NQNLEDKVRSLKTDIEESKYRQRHLKVEL 260
+ + K +A +LE+++ L D E + +L +L
Sbjct: 929 RDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQL 974
Score = 30.8 bits (68), Expect = 1.4
Identities = 42/193 (21%), Positives = 82/193 (42%), Gaps = 16/193 (8%)
Query: 100 AEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTD--DEKASHAGPANTHLKSENDK 157
+ K QE+KE A+ + + S+ +D + + + A K + +
Sbjct: 546 SRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATE 605
Query: 158 LKIALTQSAANVKNEINR--EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQL 214
+ L ++ K E+ + EK N + + +I+EL+ +L + + + + I Q
Sbjct: 606 CQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA 665
Query: 215 MSECEYVSEKLEAAERDNQNLEDKV---RSLKTDIEESKYRQRHLKVELK-------SFL 264
E EKL+ E ++ + K+ L+ E++ +HL+V LK +
Sbjct: 666 KERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKI 725
Query: 265 EVLDGKI-DDLHD 276
+VLD +I DL D
Sbjct: 726 KVLDNQIKKDLAD 738
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 51.2 bits (121), Expect = 1e-06
Identities = 43/193 (22%), Positives = 98/193 (50%), Gaps = 13/193 (6%)
Query: 92 SEQQLTKFAEKFQEVK-EAAKIAKDKT--QEKIETSSNHSQASSVNGTD-DEKASHAGPA 147
+E ++ + E Q + + +++ KDKT QEK+++ SQA S+ + + + +
Sbjct: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKE 2064
Query: 148 NTHLKSENDKLKIALTQS---AANVKNEINREKEKNTQLKRRIEELEAELREKETELKDL 204
L E++ L+ L++S NV + + + R+ + E+ + ++ L
Sbjct: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2124
Query: 205 RKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVEL---K 261
R + E + +++EKL+ ER+N +L+DKV +L+ +++ S+ Q + ++ K
Sbjct: 2125 RVRIEADEKKQL---HIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSK 2181
Query: 262 SFLEVLDGKIDDL 274
+ +E L +I+++
Sbjct: 2182 AEVETLKTQIEEM 2194
Score = 40.8 bits (94), Expect = 0.001
Identities = 38/178 (21%), Positives = 80/178 (44%), Gaps = 22/178 (12%)
Query: 97 TKFAEKFQEVK-EAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN 155
T+ +K QE++ + K+ K+K Q + + S + +K + T+LK EN
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQK----QKQKVENEKTEGTNLKREN 69
Query: 156 DKLKIALTQSAANVKNEINREKE-KNTQL----------KRRIEELEAELREKETELKDL 204
+L + + +S K +I+ E + K +Q+ K++IE+LE EL+ ++EL+
Sbjct: 70 QRL-MEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128
Query: 205 RKQSEIIPQLMSECE-----YVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK 257
++ ++ ++ C + + + ED ++EE K + +K
Sbjct: 129 QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK 186
Score = 39.7 bits (91), Expect = 0.003
Identities = 31/132 (23%), Positives = 66/132 (50%), Gaps = 8/132 (6%)
Query: 160 IALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR-KQSEIIPQLMSEC 218
+ + N+ NE+ +E+E+ ++L+ E L+EKE E ++ K S + L ++
Sbjct: 2388 VTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL 2447
Query: 219 EYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKV---ELKSFLEVL----DGKI 271
+ ++E++ A D + + K ++L + +E + + L E K+ VL +G I
Sbjct: 2448 KELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLI 2507
Query: 272 DDLHDFRRGLSK 283
++ D ++ L K
Sbjct: 2508 QEVEDGKQKLEK 2519
Score = 38.5 bits (88), Expect = 0.007
Identities = 49/223 (21%), Positives = 92/223 (41%), Gaps = 42/223 (18%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
EQ FA++ QE A+++ Q + QA TD++ S K
Sbjct: 1072 EQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS---------K 1122
Query: 153 SENDKLK---IALTQSAANVKNEINREKEKNTQL------KRRIEELEAE-LREKETELK 202
SE LK + L + ++ E+N ++N QL K + LE+E +R E +
Sbjct: 1123 SEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERE 1182
Query: 203 DLRKQSEIIPQLMSECEYVSE-------------------KLEAAERDNQNLEDKVRSLK 243
R Q PQ+ E + +S KL+ +E++ + L+ ++++++
Sbjct: 1183 SERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIR 1242
Query: 244 TDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGT 286
D+E S + ++ + + D +ID + G +L T
Sbjct: 1243 GDLETSNLQD----MQSQEISGLKDCEIDAEEKYISGPHELST 1281
Score = 37.7 bits (86), Expect = 0.012
Identities = 40/185 (21%), Positives = 81/185 (43%), Gaps = 18/185 (9%)
Query: 101 EKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKI 160
+K VK+ + ++ ++K+ + QAS + + ++ +K EN+ LK
Sbjct: 440 DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSME------EMKKENNLLKS 493
Query: 161 ALTQSAANV---KNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSE 217
Q A V + E+ K+ Q + EE++A+ +ET L+DL+++ E
Sbjct: 494 HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN-----QQE 548
Query: 218 CEYVSEKLEAA----ERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDD 273
EKL+ A E+ +D ++ + IE+ + + E K+ L L+ K +
Sbjct: 549 NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE 608
Query: 274 LHDFR 278
+ +
Sbjct: 609 YEELK 613
Score = 37.4 bits (85), Expect = 0.015
Identities = 43/217 (19%), Positives = 96/217 (44%), Gaps = 26/217 (11%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQ--EKIET-SSNHSQ----ASSVNGTDDEKASHAGP 146
Q +TK + K ++ K+ + EK+E S +H + + G + + HA
Sbjct: 1817 QLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADK 1876
Query: 147 ANTHLKSEN-DKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETEL---- 201
++ +N K+ + + +V+NE++R + + ++ LEA+L +TE
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLE 1936
Query: 202 KDLRKQSEII--------------PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE 247
KD + ++I QL E + +S+K A ++ ++ +++K + L++
Sbjct: 1937 KDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQS 1996
Query: 248 ESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284
E + + + E+K E+L D+ + + + L
Sbjct: 1997 ECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033
Score = 37.0 bits (84), Expect = 0.020
Identities = 46/213 (21%), Positives = 89/213 (41%), Gaps = 37/213 (17%)
Query: 93 EQQLTKFAEKFQEVK---EAAK---IAKDKTQEK-----IETSSNHSQASSVNGTDDEK- 140
E+++ KFQE++ E AK I K+K K + T++ + QAS+ ++K
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
Query: 141 ---ASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREK 197
+ +S L+ + + + E++R++ L + +++A L ++
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
Query: 198 ETELK--------DLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEES 249
+ K +L K + + QL + E +KL AE+ Q + K L+ +EE
Sbjct: 425 LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEM 484
Query: 250 KYRQR--------------HLKVELKSFLEVLD 268
K HL+ ELK+ + L+
Sbjct: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLN 517
Score = 37.0 bits (84), Expect = 0.020
Identities = 28/119 (23%), Positives = 56/119 (47%), Gaps = 9/119 (7%)
Query: 151 LKSENDKLKIALTQSAANVKNEINREKEKN----TQLKRRIEELEAELREKETELKDLRK 206
LKS ++L +L ++ + E+ + K N QLK+ E + +++ K L +
Sbjct: 2749 LKSSKEELNNSL-KATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2807
Query: 207 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLE 265
+ EI+ + +S+ + EK ++ ++ KV L T+I+E K E +L+
Sbjct: 2808 EKEILQKELSQLQAAQEK----QKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLD 2862
Score = 36.2 bits (82), Expect = 0.034
Identities = 30/116 (25%), Positives = 60/116 (51%), Gaps = 6/116 (5%)
Query: 151 LKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEE--LEAELREKETELKDLRKQS 208
L++ D L+ +L +S + +++ ++ E+ Q+K IEE ++AE + + ++ S
Sbjct: 828 LQNRVDSLEFSL-ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRIS 886
Query: 209 EIIPQLMSECEYVSEKLEAAE---RDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 261
++ + V+E L A E ++ Q L DKV + + +I+E K L+ LK
Sbjct: 887 KLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Score = 35.8 bits (81), Expect = 0.045
Identities = 33/142 (23%), Positives = 68/142 (47%), Gaps = 25/142 (17%)
Query: 151 LKSENDKLKIALTQSAANVKNEINREKEKNT-QLKRRIEELEAE-------LREKETELK 202
L E KL +A + + ++ +++E + QL ++ + E E L K+ E +
Sbjct: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
Query: 203 DLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKT-----DIEESKYRQR--- 254
+L+++ + SE E + ++E+ + +NL+ K+ L+T I+ +Y +R
Sbjct: 611 ELKEEKTLFSCWKSENEKLLTQMES---EKENLQSKINHLETCLKTQQIKSHEYNERVRT 667
Query: 255 ------HLKVELKSFLEVLDGK 270
+L VE+++ VLD K
Sbjct: 668 LEMDRENLSVEIRNLHNVLDSK 689
Score = 35.4 bits (80), Expect = 0.058
Identities = 43/210 (20%), Positives = 84/210 (40%), Gaps = 39/210 (18%)
Query: 95 QLTKFAEKFQEVK----EAAKIAKDKTQEKIETSSNHSQASSVNGT-------------D 137
+L K E+ E++ I ++K QEK++ S A + T +
Sbjct: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459
Query: 138 DEKASHAGPANTHLKSENDKL-KIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE 196
D++A A N + E +L K L Q KN + L + +E+ + +L +
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
Query: 197 KETELKDLRKQSEIIPQLMSECEYVS---------------------EKLEAAERDNQNL 235
K+ E+ L+ Q + QL+S+ V +K++ + N +L
Sbjct: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASL 2579
Query: 236 EDKVRSLKTDIEESKYRQRHLKVELKSFLE 265
+D + L++ + + K++ SF+E
Sbjct: 2580 QDTLEVLQSSYKNLENELELTKMDKMSFVE 2609
Score = 32.3 bits (72), Expect = 0.50
Identities = 23/106 (21%), Positives = 49/106 (46%), Gaps = 6/106 (5%)
Query: 162 LTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYV 221
L + V+ E KE+N +L+ ELE +++ +++ L+ E+ L S + +
Sbjct: 2537 LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV---LQSSYKNL 2593
Query: 222 SEKLEAAERDNQNLEDKVRSL---KTDIEESKYRQRHLKVELKSFL 264
+LE + D + +KV + +T+++ + EL+ L
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL 2639
Score = 32.0 bits (71), Expect = 0.65
Identities = 42/179 (23%), Positives = 77/179 (43%), Gaps = 11/179 (6%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSV----NGTDDEKASHAGPA 147
+E +LTK +K V++ K+ +T+ + E + + + +G + A
Sbjct: 2595 NELELTKM-DKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 148 NTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEE--LEAELREKETELKDLR 205
+KS D+LK LT + +K ++ + + + ++ E E +LR E E K
Sbjct: 2654 LEEIKSSKDQLK-ELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQA 2712
Query: 206 KQSEIIPQLMSECEYVSEKLEAAER--DNQNLE-DKVRSLKTDIEESKYRQRHLKVELK 261
+ Q E + EKL + E +Q LE D ++S K ++ S + ELK
Sbjct: 2713 LLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELK 2771
Score = 31.6 bits (70), Expect = 0.84
Identities = 46/228 (20%), Positives = 87/228 (38%), Gaps = 17/228 (7%)
Query: 49 SVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKE 108
+ A V +N TP FT ++ S+ + ++ E + K E + +
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK-YNKEVEERKRLEAEVKALQ 189
Query: 109 AAKIAKDKTQEKIETS--SNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSA 166
A K ++ Q + + H +SSV EK +HL S + + I SA
Sbjct: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP------SHLSSNSQRTPIRRDFSA 243
Query: 167 ANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLE 226
+ E ++T L+ R+ + D ++ QL ++ + + K+
Sbjct: 244 SYFSGEQEVTPSRST--------LQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 227 AAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDL 274
E Q E +++ +E + + KVEL +VL+ D+L
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDEL 343
Score = 30.4 bits (67), Expect = 1.9
Identities = 32/193 (16%), Positives = 77/193 (39%), Gaps = 20/193 (10%)
Query: 57 INSTITPN-MTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKD 115
IN+++ M + S+ F + D R ++ L +Q+ ++ +E A +
Sbjct: 982 INASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYE---- 1037
Query: 116 KTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINR 175
+ S + A N + + + K+E ++LK A + ++
Sbjct: 1038 ------DLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAF 1091
Query: 176 EKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNL 235
+E+N L +E ++ LR + T+ ++ K SE + +++ + + +
Sbjct: 1092 AEERNQNLMLELETVQQALRSEMTDNQNNSK---------SEAGGLKQEIMTLKEEQNKM 1142
Query: 236 EDKVRSLKTDIEE 248
+ +V L + E+
Sbjct: 1143 QKEVNDLLQENEQ 1155
Score = 30.0 bits (66), Expect = 2.5
Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 3/95 (3%)
Query: 173 INREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDN 232
+++ K +N +L+ +I ELE L+ E E+K Q +L + E +L E+
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKG---QVNKFQELQLQLEKAKVELIEKEKVL 336
Query: 233 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 267
D++ +++ + L+ +LK E L
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDL 371
Score = 29.6 bits (65), Expect = 3.2
Identities = 28/98 (28%), Positives = 48/98 (48%), Gaps = 10/98 (10%)
Query: 153 SENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIP 212
+EN +L + V++ +N KE +++L + E +L K +L K I+
Sbjct: 1781 NENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQ----EVQLMTKIEACIELEK---IVG 1833
Query: 213 QLMSECEYVSEKLEAAERDNQNLEDKVRS---LKTDIE 247
+L E +SEKLE D+Q L +V + L +D+E
Sbjct: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLE 1871
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 50.1 bits (118), Expect = 2e-06
Identities = 48/195 (24%), Positives = 92/195 (47%), Gaps = 15/195 (7%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDK-TQEKIET--SSNHSQASSVNGTDDE---KASHAG 145
SE Q TK A K E +E ++K K T+ +ET SS + + +++N +E + HA
Sbjct: 1193 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1252
Query: 146 PANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR 205
K E + L ++ Q + K ++ T+L+RRI+E ++ K+ ++ +L
Sbjct: 1253 KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1312
Query: 206 KQSEIIPQL---MSECEYVSEKLEAAERDNQ---NLEDKVRSLKTDIEES-KYRQRHLKV 258
E + Q +S+ Y S +R +Q L+ +V+SL+ + ++ + Q + +
Sbjct: 1313 NDVERLKQALNGLSQLTYTSG--NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAI 1370
Query: 259 ELKSFLEVLDGKIDD 273
L G +D+
Sbjct: 1371 YRTHLLSAAQGHMDE 1385
Score = 39.7 bits (91), Expect = 0.003
Identities = 35/190 (18%), Positives = 86/190 (45%), Gaps = 29/190 (15%)
Query: 106 VKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQS 165
++E ++ K+ + ++E + + + G E ++ + K EN K
Sbjct: 572 IEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMK-------- 623
Query: 166 AANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----------KQSEIIPQLM 215
+++ NE+N + +K +++R E+ +E+R+ + EL++++ + ++ +L
Sbjct: 624 -SSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLE 682
Query: 216 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL-------- 267
+ + +K+ NQ L+ ++ + D + K + +L +E+K+ L
Sbjct: 683 QKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK 742
Query: 268 --DGKIDDLH 275
D IDDL+
Sbjct: 743 SHDAIIDDLN 752
Score = 35.0 bits (79), Expect = 0.076
Identities = 42/188 (22%), Positives = 77/188 (40%), Gaps = 30/188 (15%)
Query: 80 SRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT---QEKIETSSNHSQASSVNGT 136
SR TVF E+++ E+K+ K K QEKI H+ S
Sbjct: 784 SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKI-----HALTSENTNL 838
Query: 137 DDEKASHAGPANTHLKSENDKLKIALTQSAANVKNE----------INRE----KEKNTQ 182
++ P TH +++K+ L + A E IN+E K+KN
Sbjct: 839 KKMMSNQYVPVKTH-----EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEI 893
Query: 183 LKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 242
LKR +E + +++ + L + + + Q M + + + ++ A R Q +++ +L
Sbjct: 894 LKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ---EEIVTL 950
Query: 243 KTDIEESK 250
+I+ K
Sbjct: 951 HAEIKAQK 958
Score = 34.7 bits (78), Expect = 0.100
Identities = 28/136 (20%), Positives = 69/136 (50%), Gaps = 23/136 (16%)
Query: 163 TQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELK--------------DLRKQS 208
TQ + + E+ + K++N +LK+ I L+ +LR+K ++ +L KQ
Sbjct: 1000 TQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQL 1059
Query: 209 EIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE-LKSFLEVL 267
+ + Q +E + V EKL +N ++ ++ ++ +++H+ +E +++ + L
Sbjct: 1060 KDLSQKYTEVKNVKEKL---VEENAKQTSEILAV-----QNLLQKQHVPLEQVEALKKSL 1111
Query: 268 DGKIDDLHDFRRGLSK 283
+G I++L + + + +
Sbjct: 1112 NGTIENLKEELKSMQR 1127
Score = 31.6 bits (70), Expect = 0.84
Identities = 31/138 (22%), Positives = 55/138 (39%), Gaps = 5/138 (3%)
Query: 134 NGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREK-EKNTQLKRRIEELEA 192
NG D G +++ D L I A+ RE +K L++R
Sbjct: 209 NGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQR----NL 264
Query: 193 ELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYR 252
+ E +K +++ + I L E E + E+L +++ + L DKV L+ + E
Sbjct: 265 THMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 324
Query: 253 QRHLKVELKSFLEVLDGK 270
L+ E + +L K
Sbjct: 325 ADDLESEREKLKSLLAAK 342
Score = 30.0 bits (66), Expect = 2.5
Identities = 43/185 (23%), Positives = 74/185 (40%), Gaps = 48/185 (25%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+QL ++K+ EVK K+K E+ N Q S + + P
Sbjct: 1057 KQLKDLSQKYTEVKNV----KEKLVEE-----NAKQTSEILAVQNLLQKQHVPLE----- 1102
Query: 154 ENDKLKIALTQSAANVKNEINR-----EKEKNT----------------------QLKRR 186
+ + LK +L + N+K E+ EKE+ T Q+K
Sbjct: 1103 QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1162
Query: 187 IEE----LEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 242
E+ ++A LREKE E ++ + E + +L SE + + L+ E K ++
Sbjct: 1163 FEKEVGIIKASLREKEEESQN---KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKAT 1219
Query: 243 KTDIE 247
K+D+E
Sbjct: 1220 KSDLE 1224
Score = 29.6 bits (65), Expect = 3.2
Identities = 28/135 (20%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 137 DDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE 196
D + S PA+ +S L+++L + +NEI ++ ELEA
Sbjct: 392 DSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKK------------ELEAMRTF 439
Query: 197 KETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDN----QNLEDKVRSLKTDIEESKYR 252
E+ +D K + ++EC+ ++ + E + D+ + LED ++ ++ + ES+ +
Sbjct: 440 CESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGK 499
Query: 253 QRHLKVELKSFLEVL 267
+ ++ + E L
Sbjct: 500 VKQMQTHFLALKEHL 514
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 50.1 bits (118), Expect = 2e-06
Identities = 48/195 (24%), Positives = 92/195 (47%), Gaps = 15/195 (7%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDK-TQEKIET--SSNHSQASSVNGTDDE---KASHAG 145
SE Q TK A K E +E ++K K T+ +ET SS + + +++N +E + HA
Sbjct: 1206 SEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAK 1265
Query: 146 PANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR 205
K E + L ++ Q + K ++ T+L+RRI+E ++ K+ ++ +L
Sbjct: 1266 KKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1325
Query: 206 KQSEIIPQL---MSECEYVSEKLEAAERDNQ---NLEDKVRSLKTDIEES-KYRQRHLKV 258
E + Q +S+ Y S +R +Q L+ +V+SL+ + ++ + Q + +
Sbjct: 1326 NDVERLKQALNGLSQLTYTSG--NPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAI 1383
Query: 259 ELKSFLEVLDGKIDD 273
L G +D+
Sbjct: 1384 YRTHLLSAAQGHMDE 1398
Score = 39.7 bits (91), Expect = 0.003
Identities = 35/190 (18%), Positives = 86/190 (45%), Gaps = 29/190 (15%)
Query: 106 VKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQS 165
++E ++ K+ + ++E + + + G E ++ + K EN K
Sbjct: 585 IEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMK-------- 636
Query: 166 AANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----------KQSEIIPQLM 215
+++ NE+N + +K +++R E+ +E+R+ + EL++++ + ++ +L
Sbjct: 637 -SSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLE 695
Query: 216 SECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL-------- 267
+ + +K+ NQ L+ ++ + D + K + +L +E+K+ L
Sbjct: 696 QKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK 755
Query: 268 --DGKIDDLH 275
D IDDL+
Sbjct: 756 SHDAIIDDLN 765
Score = 35.0 bits (79), Expect = 0.076
Identities = 42/188 (22%), Positives = 77/188 (40%), Gaps = 30/188 (15%)
Query: 80 SRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT---QEKIETSSNHSQASSVNGT 136
SR TVF E+++ E+K+ K K QEKI H+ S
Sbjct: 797 SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKI-----HALTSENTNL 851
Query: 137 DDEKASHAGPANTHLKSENDKLKIALTQSAANVKNE----------INRE----KEKNTQ 182
++ P TH +++K+ L + A E IN+E K+KN
Sbjct: 852 KKMMSNQYVPVKTH-----EEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEI 906
Query: 183 LKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 242
LKR +E + +++ + L + + + Q M + + + ++ A R Q +++ +L
Sbjct: 907 LKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ---EEIVTL 963
Query: 243 KTDIEESK 250
+I+ K
Sbjct: 964 HAEIKAQK 971
Score = 34.7 bits (78), Expect = 0.100
Identities = 28/136 (20%), Positives = 69/136 (50%), Gaps = 23/136 (16%)
Query: 163 TQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELK--------------DLRKQS 208
TQ + + E+ + K++N +LK+ I L+ +LR+K ++ +L KQ
Sbjct: 1013 TQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQL 1072
Query: 209 EIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVE-LKSFLEVL 267
+ + Q +E + V EKL +N ++ ++ ++ +++H+ +E +++ + L
Sbjct: 1073 KDLSQKYTEVKNVKEKL---VEENAKQTSEILAV-----QNLLQKQHVPLEQVEALKKSL 1124
Query: 268 DGKIDDLHDFRRGLSK 283
+G I++L + + + +
Sbjct: 1125 NGTIENLKEELKSMQR 1140
Score = 31.6 bits (70), Expect = 0.84
Identities = 31/138 (22%), Positives = 55/138 (39%), Gaps = 5/138 (3%)
Query: 134 NGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREK-EKNTQLKRRIEELEA 192
NG D G +++ D L I A+ RE +K L++R
Sbjct: 222 NGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQR----NL 277
Query: 193 ELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYR 252
+ E +K +++ + I L E E + E+L +++ + L DKV L+ + E
Sbjct: 278 THMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMV 337
Query: 253 QRHLKVELKSFLEVLDGK 270
L+ E + +L K
Sbjct: 338 ADDLESEREKLKSLLAAK 355
Score = 30.0 bits (66), Expect = 2.5
Identities = 43/185 (23%), Positives = 74/185 (40%), Gaps = 48/185 (25%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+QL ++K+ EVK K+K E+ N Q S + + P
Sbjct: 1070 KQLKDLSQKYTEVKNV----KEKLVEE-----NAKQTSEILAVQNLLQKQHVPLE----- 1115
Query: 154 ENDKLKIALTQSAANVKNEINR-----EKEKNT----------------------QLKRR 186
+ + LK +L + N+K E+ EKE+ T Q+K
Sbjct: 1116 QVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1175
Query: 187 IEE----LEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSL 242
E+ ++A LREKE E ++ + E + +L SE + + L+ E K ++
Sbjct: 1176 FEKEVGIIKASLREKEEESQN---KMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKAT 1232
Query: 243 KTDIE 247
K+D+E
Sbjct: 1233 KSDLE 1237
Score = 29.6 bits (65), Expect = 3.2
Identities = 28/135 (20%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 137 DDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE 196
D + S PA+ +S L+++L + +NEI ++ ELEA
Sbjct: 405 DSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKK------------ELEAMRTF 452
Query: 197 KETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDN----QNLEDKVRSLKTDIEESKYR 252
E+ +D K + ++EC+ ++ + E + D+ + LED ++ ++ + ES+ +
Sbjct: 453 CESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGK 512
Query: 253 QRHLKVELKSFLEVL 267
+ ++ + E L
Sbjct: 513 VKQMQTHFLALKEHL 527
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 50.1 bits (118), Expect = 2e-06
Identities = 50/208 (24%), Positives = 82/208 (39%), Gaps = 24/208 (11%)
Query: 90 FSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANT 149
+ SE+ K E +K + K K +E +Q + + AN
Sbjct: 791 YRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANM 850
Query: 150 HLKSENDKLKIALTQSAANVKNEINREKEKNTQL-----------------KRRIEELEA 192
L+ END L L S ++ +++ +EK L KRR+EE A
Sbjct: 851 RLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESA 910
Query: 193 EL-----REKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIE 247
+L RE + +++K S II C +SE+LE + N+ +K+R D E
Sbjct: 911 QLKEMCRRELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCE 970
Query: 248 ESK--YRQRHLKVELKSFLEVLDGKIDD 273
+ + + + S EVLD D+
Sbjct: 971 RCREFFNKEGRVKGISSTKEVLDEDTDE 998
Score = 31.2 bits (69), Expect = 1.1
Identities = 23/125 (18%), Positives = 59/125 (47%), Gaps = 3/125 (2%)
Query: 151 LKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEI 210
LK+ D L + + A ++ ++ + +++ EL ++ + +LK K+
Sbjct: 764 LKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHT 823
Query: 211 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGK 270
+ + ++ E + +E ER+N+ L++ L+ + ++ + K+ L+ L+ + K
Sbjct: 824 MREQQAQQE---DPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEK 880
Query: 271 IDDLH 275
D L+
Sbjct: 881 ADALN 885
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 49.7 bits (117), Expect = 3e-06
Identities = 48/227 (21%), Positives = 101/227 (44%), Gaps = 31/227 (13%)
Query: 77 WADSRANTVFGLGFSSE--QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVN 134
WA T GL + Q+L + + Q ++ A++ K+ ++++ ++ +
Sbjct: 897 WASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRS 956
Query: 135 GTD--------DEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRR 186
D +EK S T L E + +++ LT ++++++ + + Q +
Sbjct: 957 QDDRARQLKGLEEKVSRL---ETELDEEKNTVEL-LTDRVNRGRDQVDQLRTELMQERSA 1012
Query: 187 IEELEAELREKETELKDLR----------KQSEIIPQLMSECEYVSEKLEAAERD----- 231
++LE + E + KDL+ K S + QL S+ + + E+L+A ER+
Sbjct: 1013 RQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQ 1072
Query: 232 --NQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHD 276
N+ LE KV+ L IE+ + K +L ++ L ++D+ +
Sbjct: 1073 STNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEE 1119
Score = 40.0 bits (92), Expect = 0.002
Identities = 42/155 (27%), Positives = 69/155 (44%), Gaps = 31/155 (20%)
Query: 162 LTQSAANVKNEINREKEKNTQLKRRIEELEAELREK----------ETELKDLRKQSEII 211
L Q A V+ + +E+N + +RRI LE +L+E E L+D ++ E
Sbjct: 714 LGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAE 773
Query: 212 PQLMSECEYVSE---------------KLEAAERDNQNLEDKVRSLKTDI-EESKYRQ-- 253
Q + E S+ +LE A+R L + ++L + EE K R+
Sbjct: 774 KQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVL 833
Query: 254 RHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN 288
R K EL+ +LD +D L+ + L K+G D+
Sbjct: 834 RRGKAELEEQKRLLDRTVDRLN---KELEKIGEDS 865
Score = 35.4 bits (80), Expect = 0.058
Identities = 37/195 (18%), Positives = 83/195 (42%), Gaps = 30/195 (15%)
Query: 91 SSEQQLTKFAEKFQ-----EVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAG 145
+ + +LT+ E+ Q EVK+ K+ + + + + S + + + A
Sbjct: 359 AGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQ 418
Query: 146 PANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE-------KE 198
+N L+ N+K +++ ++ L+ ++ EL+ +L+ KE
Sbjct: 419 QSNKELQ---------------NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKE 463
Query: 199 TELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKV 258
LKDL + E++ +++ + V E+L ER+ L+ +LK ++ H++
Sbjct: 464 VLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKG---ALKEEVASRDQEVEHVRQ 520
Query: 259 ELKSFLEVLDGKIDD 273
+ + E L + D
Sbjct: 521 QYQRDTEQLRRSMQD 535
Score = 33.5 bits (75), Expect = 0.22
Identities = 35/204 (17%), Positives = 79/204 (38%), Gaps = 30/204 (14%)
Query: 79 DSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKT--------QEKIETSSNHSQA 130
D RA + GL E+++++ + E K ++ D+ Q + E S
Sbjct: 958 DDRARQLKGL----EEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSAR 1013
Query: 131 SSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREK------------E 178
+ T L S K + + S +N++ +E+
Sbjct: 1014 QDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQS 1073
Query: 179 KNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDK 238
N +L+R+++EL ++ ++ + D + Q L + + +++ AE + + L+
Sbjct: 1074 TNRKLERKVKELSIQIEDERQHVNDQKDQ------LSLRVKALKRQVDEAEEEIERLDGL 1127
Query: 239 VRSLKTDIEESKYRQRHLKVELKS 262
+ + ++EE L+ +KS
Sbjct: 1128 RKKAQREVEEQHEVNEQLQARIKS 1151
Score = 31.6 bits (70), Expect = 0.84
Identities = 33/183 (18%), Positives = 80/183 (43%), Gaps = 19/183 (10%)
Query: 91 SSEQQLTKFAEKFQ-EVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANT 149
S +Q++ +++Q + ++ + +D TQ+ + + S++ +
Sbjct: 510 SRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETG 569
Query: 150 HLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSE 209
H +S K K ++ K++ QL+ EE+E EL EK ++ L+++ E
Sbjct: 570 HWQSMFQKNK-----------EDLRATKQELLQLRMEKEEMEEELGEK---IEVLQRELE 615
Query: 210 IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG 269
+ + ++E +++ +++++ L+ + + + RH EL+ L VL
Sbjct: 616 QARASAGD----TRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRV 671
Query: 270 KID 272
+ D
Sbjct: 672 EAD 674
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 49.3 bits (116), Expect = 4e-06
Identities = 57/232 (24%), Positives = 100/232 (43%), Gaps = 22/232 (9%)
Query: 76 QWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNG 135
Q A+S A EQ+LT+ ++ V + + KD+ + + S Q
Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRIDYERVSQERTV-KDQDITRFQNSLKELQLQKQKV 1573
Query: 136 TDD-----EKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEE- 189
++ AS L+ E + ++ +L + A + N + ++ E+ + +K+R E+
Sbjct: 1574 EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITN-LTQQLEQASIVKKRSEDD 1632
Query: 190 -------LEAELREKETELKDLRKQSEIIP----QLMSECEYVSEKLEAAERDNQNLEDK 238
L+ LREK+ ++LR+ S + QL+ E E V + E + +EDK
Sbjct: 1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDK 1692
Query: 239 VRSL---KTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTD 287
RSL K +IE + +L E E L + D RRG S+ +D
Sbjct: 1693 SRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
Score = 38.5 bits (88), Expect = 0.007
Identities = 39/146 (26%), Positives = 69/146 (47%), Gaps = 12/146 (8%)
Query: 148 NTHLKSENDKLKIALTQSAAN---VKNEINREKEKNTQLKRRIEELEAELR---EKETEL 201
N L E +LK LTQ+ N V+ +I ++K +++ +R ++LE ELR + TE
Sbjct: 1402 NRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE 1461
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 261
KQS L + + +K + ER Q L DK + + +E+ R + ++ +L+
Sbjct: 1462 SVRYKQS-----LDDAAKTIQDKNKEIERLKQ-LIDKETNDRKCLEDENARLQRVQYDLQ 1515
Query: 262 SFLEVLDGKIDDLHDFRRGLSKLGTD 287
I+ L + L++L D
Sbjct: 1516 KANSSATETINKLKVQEQELTRLRID 1541
Score = 35.0 bits (79), Expect = 0.076
Identities = 39/221 (17%), Positives = 90/221 (40%), Gaps = 40/221 (18%)
Query: 75 GQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVN 134
G+ A + +G +++T+ + ++ K K +D+ ++ +++ Q
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQ---KNDYDQLQKAR 1146
Query: 135 GTDDEKAS----HAGPANTHLKSENDKLKIALTQSAANVKNEINREKEK-----NTQLKR 185
+ E + A + E ++L++ L + K E E K N ++
Sbjct: 1147 QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR-KREYENELAKVRNHYNEEMSN 1205
Query: 186 RIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD 245
+ E E+ +T +K++ Q E + + + +L+ R+N++L+D++ L
Sbjct: 1206 LRNKYETEINITKTTIKEISMQKE------DDSKNLRNQLDRLSRENRDLKDEIVRLNDS 1259
Query: 246 I----------EESKYRQR-----------HLKVELKSFLE 265
I EE+ +Q+ HL++ELK ++
Sbjct: 1260 ILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQ 1300
Score = 32.3 bits (72), Expect = 0.50
Identities = 42/175 (24%), Positives = 68/175 (38%), Gaps = 18/175 (10%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
+Q+ A Q ++EAAK +DK +E IE Q E+A L
Sbjct: 1300 QQRSEDNARHKQSLEEAAKTIQDKNKE-IERLKAEFQ---------EEAKRRWEYENELS 1349
Query: 153 SENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETEL-KDLRKQSEII 211
+ + + EIN K QL + EE + R + L ++ R SE I
Sbjct: 1350 KVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEI 1409
Query: 212 PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEV 266
+L + +E L E D ++ K E R++ L+VEL+ ++
Sbjct: 1410 KRLKNTLTQTTENLRRVEED-------IQQQKATGSEVSQRKQQLEVELRQVTQM 1457
Score = 31.2 bits (69), Expect = 1.1
Identities = 26/104 (25%), Positives = 52/104 (50%), Gaps = 15/104 (14%)
Query: 154 ENDKLKIALTQSAANVKNEINREK---EKNTQLKRRIEELEAELREKETELKDLRKQSEI 210
E DK ++ +++E+NR K E T++K+R LE E ++ + +L + Q
Sbjct: 1823 EQDKARLQ------RLEDELNRAKSTLEAETRVKQR---LECEKQQIQNDLNQWKTQYSR 1873
Query: 211 IPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQR 254
+ + + E EK +ER+ +L ++ L+ +I+ + R R
Sbjct: 1874 KEEAIRKIESEREK---SEREKNSLRSEIERLQAEIKRIEERCR 1914
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 48.9 bits (115), Expect = 5e-06
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 8/115 (6%)
Query: 182 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 241
+LK++ ++L AE ++ +L K +E++ Q + V EK E E+D + LE+KV +
Sbjct: 853 KLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLN 912
Query: 242 LKTDIEESKY---RQRHLKVELKSFLEVLDGKIDDLH-----DFRRGLSKLGTDN 288
LKT +E+ + + K EL K++++H ++ + L +L DN
Sbjct: 913 LKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDN 967
Score = 40.4 bits (93), Expect = 0.002
Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 18/160 (11%)
Query: 98 KFAEKFQEVKEAAK------IAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
K +K ++ KE AK +A ++ QE++E S N Q +K G N L
Sbjct: 382 KKRKKLKKRKEGAKAEHNLKVASEEKQERLERSEN-KQPQDSQSYGKKKDEMFG--NFML 438
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE-----KETELKDLRK 206
K + LK + +KN+ R+++K Q + I E+ A + +E K + +
Sbjct: 439 KRDIAMLK----EELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQ 494
Query: 207 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDI 246
S+ + L +E ++ KLE + + + LE +V SL +++
Sbjct: 495 YSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNL 534
Score = 34.3 bits (77), Expect = 0.13
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 20/205 (9%)
Query: 71 SQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE--TSSNHS 128
SQ +G+ D +FG F ++ + E+ +K + + K ++I+ T N +
Sbjct: 422 SQSYGKKKDE----MFG-NFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINAN 476
Query: 129 QASSVNGTDD---EKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEK-NTQLK 184
SV ++ +K + LK+EN +L L + N K + E E ++ L
Sbjct: 477 FEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHN-KERLEAEVESLHSNLA 535
Query: 185 RRIEELEAELREKETEL-----KDLRKQSEI---IPQLMSECEYVSEKLEAAERDNQNLE 236
I E L K+ EL D+ + + I QL + E ++E++ A L+
Sbjct: 536 TAINEYNEILERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLK 595
Query: 237 DKVRSLKTDIEESKYRQRHLKVELK 261
K+R + + E ++++LK
Sbjct: 596 GKLRETRDALREKTLALESVQLDLK 620
Score = 32.3 bits (72), Expect = 0.50
Identities = 39/175 (22%), Positives = 67/175 (38%), Gaps = 16/175 (9%)
Query: 102 KFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIA 161
K QE E + K +EK+ H + V G + KSE D+ +
Sbjct: 891 KVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE---------LGKVQEY-KSELDERAMQ 940
Query: 162 LTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEIIPQLMSE 217
+ + + E EK QL++ ++ A L++KE LKD+ K + +E
Sbjct: 941 AIEKLEEIHLQKQAEYEK--QLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTE 998
Query: 218 CEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKID 272
E E A + N ++ +K+ I + K ++ FL L + D
Sbjct: 999 LEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPD 1053
Score = 29.3 bits (64), Expect = 4.2
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 22/165 (13%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+Q+ K KF +K + +D +EK + A D ++A H +
Sbjct: 582 EQVHKARVKFNTLKGKLRETRDALREK-------TLALESVQLDLKQAQHRIKEMKQMHP 634
Query: 154 ENDKLKIALTQSAANVKNEINREKE-KNTQLKRRIEELEAELREKETEL----------- 201
N + K + + N E R++E +N L+R++E+ E KE +
Sbjct: 635 -NGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGK 693
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDI 246
+DL ++ +LM+E Y+ EKL E++ E VR + ++
Sbjct: 694 EDLLEERN--KELMNEYNYLKEKLLQYEKEKAEREVIVREFQEEL 736
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 48.9 bits (115), Expect = 5e-06
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 8/115 (6%)
Query: 182 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 241
+LK++ ++L AE ++ +L K +E++ Q + V EK E E+D + LE+KV +
Sbjct: 882 KLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLN 941
Query: 242 LKTDIEESKY---RQRHLKVELKSFLEVLDGKIDDLH-----DFRRGLSKLGTDN 288
LKT +E+ + + K EL K++++H ++ + L +L DN
Sbjct: 942 LKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDN 996
Score = 40.4 bits (93), Expect = 0.002
Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 18/160 (11%)
Query: 98 KFAEKFQEVKEAAK------IAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
K +K ++ KE AK +A ++ QE++E S N Q +K G N L
Sbjct: 411 KKRKKLKKRKEGAKAEHNLKVASEEKQERLERSEN-KQPQDSQSYGKKKDEMFG--NFML 467
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE-----KETELKDLRK 206
K + LK + +KN+ R+++K Q + I E+ A + +E K + +
Sbjct: 468 KRDIAMLK----EELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQ 523
Query: 207 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDI 246
S+ + L +E ++ KLE + + + LE +V SL +++
Sbjct: 524 YSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNL 563
Score = 34.3 bits (77), Expect = 0.13
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 20/205 (9%)
Query: 71 SQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE--TSSNHS 128
SQ +G+ D +FG F ++ + E+ +K + + K ++I+ T N +
Sbjct: 451 SQSYGKKKDE----MFG-NFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINAN 505
Query: 129 QASSVNGTDD---EKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEK-NTQLK 184
SV ++ +K + LK+EN +L L + N K + E E ++ L
Sbjct: 506 FEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHN-KERLEAEVESLHSNLA 564
Query: 185 RRIEELEAELREKETEL-----KDLRKQSEI---IPQLMSECEYVSEKLEAAERDNQNLE 236
I E L K+ EL D+ + + I QL + E ++E++ A L+
Sbjct: 565 TAINEYNEILERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLK 624
Query: 237 DKVRSLKTDIEESKYRQRHLKVELK 261
K+R + + E ++++LK
Sbjct: 625 GKLRETRDALREKTLALESVQLDLK 649
Score = 32.3 bits (72), Expect = 0.50
Identities = 39/175 (22%), Positives = 67/175 (38%), Gaps = 16/175 (9%)
Query: 102 KFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIA 161
K QE E + K +EK+ H + V G + KSE D+ +
Sbjct: 920 KVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE---------LGKVQEY-KSELDERAMQ 969
Query: 162 LTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEIIPQLMSE 217
+ + + E EK QL++ ++ A L++KE LKD+ K + +E
Sbjct: 970 AIEKLEEIHLQKQAEYEK--QLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTE 1027
Query: 218 CEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKID 272
E E A + N ++ +K+ I + K ++ FL L + D
Sbjct: 1028 LEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPD 1082
Score = 29.3 bits (64), Expect = 4.2
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 22/165 (13%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+Q+ K KF +K + +D +EK + A D ++A H +
Sbjct: 611 EQVHKARVKFNTLKGKLRETRDALREK-------TLALESVQLDLKQAQHRIKEMKQMHP 663
Query: 154 ENDKLKIALTQSAANVKNEINREKE-KNTQLKRRIEELEAELREKETEL----------- 201
N + K + + N E R++E +N L+R++E+ E KE +
Sbjct: 664 -NGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGK 722
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDI 246
+DL ++ +LM+E Y+ EKL E++ E VR + ++
Sbjct: 723 EDLLEERN--KELMNEYNYLKEKLLQYEKEKAEREVIVREFQEEL 765
>gi|239743705 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1139
Score = 48.9 bits (115), Expect = 5e-06
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 8/115 (6%)
Query: 182 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 241
+LK++ ++L AE ++ +L K +E++ Q + V EK E E+D + LE+KV +
Sbjct: 882 KLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKVQEKCEKLEKDKKMLEEKVLN 941
Query: 242 LKTDIEESKY---RQRHLKVELKSFLEVLDGKIDDLH-----DFRRGLSKLGTDN 288
LKT +E+ + + K EL K++++H ++ + L +L DN
Sbjct: 942 LKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQKQAEYEKQLEQLNKDN 996
Score = 40.4 bits (93), Expect = 0.002
Identities = 41/160 (25%), Positives = 75/160 (46%), Gaps = 18/160 (11%)
Query: 98 KFAEKFQEVKEAAK------IAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
K +K ++ KE AK +A ++ QE++E S N Q +K G N L
Sbjct: 411 KKRKKLKKRKEGAKAEHNLKVASEEKQERLERSEN-KQPQDSQSYGKKKDEMFG--NFML 467
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE-----KETELKDLRK 206
K + LK + +KN+ R+++K Q + I E+ A + +E K + +
Sbjct: 468 KRDIAMLK----EELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQ 523
Query: 207 QSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDI 246
S+ + L +E ++ KLE + + + LE +V SL +++
Sbjct: 524 YSQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHSNL 563
Score = 34.3 bits (77), Expect = 0.13
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 20/205 (9%)
Query: 71 SQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE--TSSNHS 128
SQ +G+ D +FG F ++ + E+ +K + + K ++I+ T N +
Sbjct: 451 SQSYGKKKDE----MFG-NFMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINAN 505
Query: 129 QASSVNGTDD---EKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEK-NTQLK 184
SV ++ +K + LK+EN +L L + N K + E E ++ L
Sbjct: 506 FEKSVRLNEEMITKKVAQYSQQLNDLKAENARLNSKLEKEKHN-KERLEAEVESLHSNLA 564
Query: 185 RRIEELEAELREKETEL-----KDLRKQSEI---IPQLMSECEYVSEKLEAAERDNQNLE 236
I E L K+ EL D+ + + I QL + E ++E++ A L+
Sbjct: 565 TAINEYNEILERKDLELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLK 624
Query: 237 DKVRSLKTDIEESKYRQRHLKVELK 261
K+R + + E ++++LK
Sbjct: 625 GKLRETRDALREKTLALESVQLDLK 649
Score = 32.3 bits (72), Expect = 0.50
Identities = 39/175 (22%), Positives = 67/175 (38%), Gaps = 16/175 (9%)
Query: 102 KFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSENDKLKIA 161
K QE E + K +EK+ H + V G + KSE D+ +
Sbjct: 920 KVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVE---------LGKVQEY-KSELDERAMQ 969
Query: 162 LTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQSEIIPQLMSE 217
+ + + E EK QL++ ++ A L++KE LKD+ K + +E
Sbjct: 970 AIEKLEEIHLQKQAEYEK--QLEQLNKDNTASLKKKELTLKDVECKFSKMKTAYEDVTTE 1027
Query: 218 CEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKID 272
E E A + N ++ +K+ I + K ++ FL L + D
Sbjct: 1028 LEEYKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKERMEYFLSTLPMRPD 1082
Score = 29.3 bits (64), Expect = 4.2
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 22/165 (13%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
+Q+ K KF +K + +D +EK + A D ++A H +
Sbjct: 611 EQVHKARVKFNTLKGKLRETRDALREK-------TLALESVQLDLKQAQHRIKEMKQMHP 663
Query: 154 ENDKLKIALTQSAANVKNEINREKE-KNTQLKRRIEELEAELREKETEL----------- 201
N + K + + N E R++E +N L+R++E+ E KE +
Sbjct: 664 -NGEAKESQSIGKQNSSEERIRQRELENLLLERQLEDARKEGDNKEIVINIHRDCLENGK 722
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDI 246
+DL ++ +LM+E Y+ EKL E++ E VR + ++
Sbjct: 723 EDLLEERN--KELMNEYNYLKEKLLQYEKEKAEREVIVREFQEEL 765
>gi|239755047 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 48.5 bits (114), Expect = 7e-06
Identities = 31/117 (26%), Positives = 64/117 (54%), Gaps = 12/117 (10%)
Query: 182 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 241
+LK++ +L AE +E +L K +E++ Q + V EK E E+D + LE++V +
Sbjct: 852 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 911
Query: 242 LKTDIEE-----SKYRQRHLKVELKSFLEVLDGKIDDLH-----DFRRGLSKLGTDN 288
LKT +E+ K ++ +++ ++ E+ K++++H ++ + L +L DN
Sbjct: 912 LKTHMEKDMVELGKLQEYKSELDERAVQEI--EKLEEIHLQKQAEYEKQLEQLNKDN 966
Score = 31.2 bits (69), Expect = 1.1
Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 24/131 (18%)
Query: 139 EKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKE 198
EK G L+ ++K + Q N + + ++ K L+ RI + E E E
Sbjct: 606 EKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLE 664
Query: 199 TELKDLRKQS---EII--------------------PQLMSECEYVSEKLEAAERDNQNL 235
+L+D RK+ EI+ +LM E Y+ EKL E++
Sbjct: 665 RQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAER 724
Query: 236 EDKVRSLKTDI 246
E VR + ++
Sbjct: 725 EVIVREFQEEL 735
Score = 31.2 bits (69), Expect = 1.1
Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 6/120 (5%)
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQ 207
KSE D+ + + + + E EK QL++ ++ A L++KE LKD+ K
Sbjct: 930 KSELDERAVQEIEKLEEIHLQKQAEYEK--QLEQLNKDNTASLKKKELTLKDVECKFSKM 987
Query: 208 SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 267
++ +E E E A + N ++ K+ I + K +K FL L
Sbjct: 988 KTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTL 1047
>gi|239749578 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1002
Score = 48.5 bits (114), Expect = 7e-06
Identities = 31/117 (26%), Positives = 64/117 (54%), Gaps = 12/117 (10%)
Query: 182 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 241
+LK++ +L AE +E +L K +E++ Q + V EK E E+D + LE++V +
Sbjct: 745 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 804
Query: 242 LKTDIEE-----SKYRQRHLKVELKSFLEVLDGKIDDLH-----DFRRGLSKLGTDN 288
LKT +E+ K ++ +++ ++ E+ K++++H ++ + L +L DN
Sbjct: 805 LKTHMEKDMVELGKLQEYKSELDERAVQEI--EKLEEIHLQKQAEYEKQLEQLNKDN 859
Score = 31.2 bits (69), Expect = 1.1
Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 24/131 (18%)
Query: 139 EKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKE 198
EK G L+ ++K + Q N + + ++ K L+ RI + E E E
Sbjct: 499 EKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLE 557
Query: 199 TELKDLRKQS---EII--------------------PQLMSECEYVSEKLEAAERDNQNL 235
+L+D RK+ EI+ +LM E Y+ EKL E++
Sbjct: 558 RQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAER 617
Query: 236 EDKVRSLKTDI 246
E VR + ++
Sbjct: 618 EVIVREFQEEL 628
Score = 30.0 bits (66), Expect = 2.5
Identities = 29/125 (23%), Positives = 52/125 (41%), Gaps = 6/125 (4%)
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQ 207
KSE D+ + + + + E EK QL++ ++ A L++KE LKD+ K
Sbjct: 823 KSELDERAVQEIEKLEEIHLQKQAEYEK--QLEQLNKDNTASLKKKELTLKDVECKFSKM 880
Query: 208 SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 267
++ +E E E A + N ++ K+ I + K ++ FL L
Sbjct: 881 KTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFMEKERMEYFLSTL 940
Query: 268 DGKID 272
+ D
Sbjct: 941 PMRPD 945
>gi|239743724 PREDICTED: ankyrin repeat domain 18A [Homo sapiens]
Length = 1415
Score = 48.5 bits (114), Expect = 7e-06
Identities = 31/117 (26%), Positives = 64/117 (54%), Gaps = 12/117 (10%)
Query: 182 QLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRS 241
+LK++ +L AE +E +L K +E++ Q + V EK E E+D + LE++V +
Sbjct: 852 KLKQKFNDLVAEKEAVSSECVNLAKDNEVLHQELLSMRNVQEKCEKLEKDKKMLEEEVLN 911
Query: 242 LKTDIEE-----SKYRQRHLKVELKSFLEVLDGKIDDLH-----DFRRGLSKLGTDN 288
LKT +E+ K ++ +++ ++ E+ K++++H ++ + L +L DN
Sbjct: 912 LKTHMEKDMVELGKLQEYKSELDERAVQEI--EKLEEIHLQKQAEYEKQLEQLNKDN 966
Score = 31.2 bits (69), Expect = 1.1
Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 24/131 (18%)
Query: 139 EKASHAGPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKE 198
EK G L+ ++K + Q N + + ++ K L+ RI + E E E
Sbjct: 606 EKTLALGSVQLDLRQAQHRIK-EMKQMHPNGEAKESQSIGKQNSLEERIRQQELENLLLE 664
Query: 199 TELKDLRKQS---EII--------------------PQLMSECEYVSEKLEAAERDNQNL 235
+L+D RK+ EI+ +LM E Y+ EKL E++
Sbjct: 665 RQLEDARKEGDNKEIVINIHRDCLENGKEDLLEERNKELMKEYNYLKEKLLQCEKEKAER 724
Query: 236 EDKVRSLKTDI 246
E VR + ++
Sbjct: 725 EVIVREFQEEL 735
Score = 31.2 bits (69), Expect = 1.1
Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 6/120 (5%)
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR----KQ 207
KSE D+ + + + + E EK QL++ ++ A L++KE LKD+ K
Sbjct: 930 KSELDERAVQEIEKLEEIHLQKQAEYEK--QLEQLNKDNTASLKKKELTLKDVECKFSKM 987
Query: 208 SEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVL 267
++ +E E E A + N ++ K+ I + K +K FL L
Sbjct: 988 KTAYEEVTTELEEFKEAFAGAVKANNSMSKKLMKSDKKIAVISTKLFTEKQRMKYFLSTL 1047
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 48.5 bits (114), Expect = 7e-06
Identities = 38/157 (24%), Positives = 70/157 (44%), Gaps = 7/157 (4%)
Query: 94 QQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKS 153
Q++ +F ++ + +K+AA A+ Q N A + + DE SH L+
Sbjct: 1103 QKMEEFRKEIETLKQAA--AQKSQQLSALQEENVKLAEELGRSRDEVTSHQ-----KLEE 1155
Query: 154 ENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQ 213
E L L + I E+ L++ I A L EK+ EL+ LR + ++
Sbjct: 1156 ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG 1215
Query: 214 LMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESK 250
+ + + ++ E D LE KV++L+ ++E+K
Sbjct: 1216 ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENK 1252
Score = 45.1 bits (105), Expect = 7e-05
Identities = 41/195 (21%), Positives = 91/195 (46%), Gaps = 21/195 (10%)
Query: 92 SEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
+EQ + A+K +E K+ + ++K+ETS N Q E + A +
Sbjct: 940 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ---------ELKARYERATSET 990
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEII 211
K++++++ L ++ + ++++ +E+N+ L + +EEL + +K + +I+
Sbjct: 991 KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-ADKAKAAQTAEDAMQIM 1049
Query: 212 PQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLK--VELKSFLEVLDG 269
Q+ E LE ++ N L++++ +LK + +LK EL E+L
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLK---------ENNLKNVEELNKSKELLTV 1100
Query: 270 KIDDLHDFRRGLSKL 284
+ + +FR+ + L
Sbjct: 1101 ENQKMEEFRKEIETL 1115
Score = 40.8 bits (94), Expect = 0.001
Identities = 43/194 (22%), Positives = 83/194 (42%), Gaps = 35/194 (18%)
Query: 108 EAAKIAKDKTQ-EKIETSSNHSQASSVNGTDDEKASHAGPANT--------------HLK 152
E A+ A+ KTQ EK+ H + N D E+A+HA L+
Sbjct: 606 ETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLE 665
Query: 153 SENDKLKIALTQSAANVKNEINREKEKNTQLK-------------RRIEELEAELREKET 199
+ KL A Q +++ +N+ +E ++K + I+ ++L+ E
Sbjct: 666 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 725
Query: 200 ELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLE-------DKVRSLKTDIEESKYR 252
+L DL + + SE + + ++LEAAE+ ++LE K S+ +++ + +
Sbjct: 726 KLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELK 785
Query: 253 QRHLKVELKSFLEV 266
+L+ L +V
Sbjct: 786 LTNLQENLSEVSQV 799
Score = 38.5 bits (88), Expect = 0.007
Identities = 33/174 (18%), Positives = 72/174 (41%), Gaps = 16/174 (9%)
Query: 93 EQQLTKFAEKFQ-EVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHL 151
E+QL K EK + ++ E K++ D + + + + K + A + L
Sbjct: 870 EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL 929
Query: 152 KSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLR------ 205
+ + + + QS + EK+ +L+R++ +LE ++ + ++L+
Sbjct: 930 QKSIEDMTVKAEQSQQEAAKKHEEEKK---ELERKLSDLEKKMETSHNQCQELKARYERA 986
Query: 206 ------KQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQ 253
K EI+ L +KL+ A +N L ++ L+ +++K Q
Sbjct: 987 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ 1040
Score = 36.2 bits (82), Expect = 0.034
Identities = 45/193 (23%), Positives = 85/193 (44%), Gaps = 27/193 (13%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDE--------KASHA 144
E L K E +VKE ++ + K E+ + N + S + T+++ KAS
Sbjct: 683 EDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFT--SQLKATEEKLLDLDALRKASSE 739
Query: 145 GPANTHLKSENDKLKIALTQSAANVKN---EINREKEKNTQLKRRIEELEAELREKETEL 201
G KSE KL+ L + +K+ E N E K + + R ++ E +L + L
Sbjct: 740 G------KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 793
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 261
++ S++ L E + + EK A + +++ RS++ + + ++ + L
Sbjct: 794 SEV---SQVKETLEKELQILKEKFAEASEEAVSVQ---RSMQETVNKLHQKEEQFNM-LS 846
Query: 262 SFLEVLDGKIDDL 274
S LE L + D+
Sbjct: 847 SDLEKLRENLADM 859
Score = 35.0 bits (79), Expect = 0.076
Identities = 36/185 (19%), Positives = 78/185 (42%), Gaps = 12/185 (6%)
Query: 91 SSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPAN-- 148
++ + TK E Q +++ +DK + E +S Q +KA A A
Sbjct: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
Query: 149 -------THLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETEL 201
T K+E Q+ A ++NE++ KE N + + + + L + ++
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
Query: 202 KDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELK 261
++ RK+ E + Q ++ S++L A + +N L +++ + ++ + + V
Sbjct: 1106 EEFRKEIETLKQAAAQ---KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN 1162
Query: 262 SFLEV 266
LE+
Sbjct: 1163 QLLEM 1167
Score = 33.5 bits (75), Expect = 0.22
Identities = 40/192 (20%), Positives = 78/192 (40%), Gaps = 29/192 (15%)
Query: 93 EQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLK 152
E++L EKF E E A + QE + + H + N L
Sbjct: 804 EKELQILKEKFAEASEEAVSVQRSMQETV--NKLHQKEEQFN---------------MLS 846
Query: 153 SENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELRE----KETELKDLRKQS 208
S+ +KL+ ++ A+++ + + E+ QL + E+LE ++ E L K +
Sbjct: 847 SDLEKLR----ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 902
Query: 209 EIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKY----RQRHLKVELKSFL 264
+ + + E + KL A + L+ + + E+S+ + K EL+ L
Sbjct: 903 DELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 962
Query: 265 EVLDGKIDDLHD 276
L+ K++ H+
Sbjct: 963 SDLEKKMETSHN 974
Score = 31.2 bits (69), Expect = 1.1
Identities = 39/161 (24%), Positives = 67/161 (41%), Gaps = 21/161 (13%)
Query: 95 QLTKFAEKFQEVKEAAKIAKD-KTQEKIETSSNHSQASS-VNGTDDEKASHAGPANTHLK 152
++ K E+++ +A+D Q +E + Q + V D EK +
Sbjct: 377 EVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN------Q 430
Query: 153 SENDKLKIALTQSAANVKNEINREKEKNT-QLKRRIEELEAELREKETELKDLRKQSE-- 209
E +K K+ Q ++ + E T K RI ELE +L + E+ +LR++ E
Sbjct: 431 LEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 490
Query: 210 -------IIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLK 243
+ L+ E + EKLE D+Q ++ SLK
Sbjct: 491 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR---EITSLK 528
Score = 29.3 bits (64), Expect = 4.2
Identities = 29/132 (21%), Positives = 61/132 (46%), Gaps = 8/132 (6%)
Query: 158 LKIALTQSAANVKNEINREKEKNTQLKRRIEELEAEL-REKETELKDLRKQSEIIPQLMS 216
+ ++L Q ++++ ++ + T +R I L+ +ET K+++ +L
Sbjct: 498 MSLSLLQEISSLQEKLEVTR---TDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 554
Query: 217 ECEYVSEKLEAAERDNQNLEDKVRS-LKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLH 275
E E + KLE A ++N ++ +S L+T I + LKV SF + L + +
Sbjct: 555 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV---SFSKGLGTETAEFA 611
Query: 276 DFRRGLSKLGTD 287
+ + + K+ D
Sbjct: 612 ELKTQIEKMRLD 623
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,150,591
Number of Sequences: 37866
Number of extensions: 362635
Number of successful extensions: 7426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 421
Number of HSP's successfully gapped in prelim test: 831
Number of HSP's that attempted gapping in prelim test: 3177
Number of HSP's gapped (non-prelim): 3663
length of query: 288
length of database: 18,247,518
effective HSP length: 101
effective length of query: 187
effective length of database: 14,423,052
effective search space: 2697110724
effective search space used: 2697110724
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.