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Search of human proteins with 110347568
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110347568 centrosomal protein 152kDa [Homo sapiens]
(1654 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110347568 centrosomal protein 152kDa [Homo sapiens] 3288 0.0
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 139 3e-32
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 139 3e-32
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 139 3e-32
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 139 3e-32
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 127 7e-29
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 124 1e-27
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 119 3e-26
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 118 4e-26
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 113 2e-24
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 112 3e-24
gi|55770834 centromere protein F [Homo sapiens] 111 5e-24
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 109 3e-23
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 108 3e-23
gi|71061468 centromere protein E [Homo sapiens] 108 4e-23
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 106 2e-22
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 106 2e-22
gi|21735548 centrosomal protein 2 [Homo sapiens] 105 3e-22
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 105 5e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 103 1e-21
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 102 2e-21
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 102 3e-21
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 102 3e-21
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 102 3e-21
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 101 7e-21
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 101 7e-21
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 100 9e-21
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 100 9e-21
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 100 1e-20
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 100 1e-20
>gi|110347568 centrosomal protein 152kDa [Homo sapiens]
Length = 1654
Score = 3288 bits (8526), Expect = 0.0
Identities = 1654/1654 (100%), Positives = 1654/1654 (100%)
Query: 1 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 60
MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
Sbjct: 1 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG 60
Query: 61 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 120
TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
Sbjct: 61 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH 120
Query: 121 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 180
PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
Sbjct: 121 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ 180
Query: 181 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 240
GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
Sbjct: 181 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ 240
Query: 241 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 300
LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
Sbjct: 241 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 300
Query: 301 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 360
EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
Sbjct: 301 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 360
Query: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 420
SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
Sbjct: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 420
Query: 421 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 480
NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
Sbjct: 421 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 480
Query: 481 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 540
ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
Sbjct: 481 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD 540
Query: 541 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 600
EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
Sbjct: 541 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 600
Query: 601 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 660
EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
Sbjct: 601 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV 660
Query: 661 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 720
QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
Sbjct: 661 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD 720
Query: 721 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 780
KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
Sbjct: 721 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT 780
Query: 781 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 840
IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
Sbjct: 781 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 840
Query: 841 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 900
IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
Sbjct: 841 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 900
Query: 901 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 960
FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
Sbjct: 901 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW 960
Query: 961 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 1020
NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
Sbjct: 961 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL 1020
Query: 1021 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1080
DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
Sbjct: 1021 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK 1080
Query: 1081 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1140
WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
Sbjct: 1081 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1140
Query: 1141 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL 1200
HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL
Sbjct: 1141 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL 1200
Query: 1201 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL 1260
PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL
Sbjct: 1201 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL 1260
Query: 1261 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV 1320
ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV
Sbjct: 1261 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV 1320
Query: 1321 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS 1380
KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS
Sbjct: 1321 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS 1380
Query: 1381 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY 1440
KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY
Sbjct: 1381 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY 1440
Query: 1441 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD 1500
PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD
Sbjct: 1441 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD 1500
Query: 1501 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY 1560
VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY
Sbjct: 1501 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY 1560
Query: 1561 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS 1620
LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS
Sbjct: 1561 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS 1620
Query: 1621 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD 1654
TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
Sbjct: 1621 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD 1654
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 139 bits (349), Expect = 3e-32
Identities = 207/1022 (20%), Positives = 459/1022 (44%), Gaps = 114/1022 (11%)
Query: 236 MQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ 295
+Q+ + + +AKE +L+ E+ ++E +++ L + + +EK+ L L+ +L+
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 296 NGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRA 355
+E ++L A+ + LE + ++ E+ + + + + + QQ++DL
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-------- 956
Query: 356 REQHESIVMGLTKKYEEQVLSLQKNLDATVTA---LKEQEDICSRLKDHVKQLERNQEAI 412
++ EE+ + QK VTA +K+ ED + D +L + ++ +
Sbjct: 957 ------------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 413 KLEKTEIINKLTRSLEESQKQCAHLLQSGSVQE--VAQLQFQLQQAQKAHAMSANMNKAL 470
+ E I+ LT +L E +++ +L + + E +++L+ +L++ +K+ + + L
Sbjct: 1005 E----ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 471 QEELTELKDEIS-LYESAAKLGIHPSDSEGELNIELTE-----SYVDLGIKKVNWKKSKV 524
+ + ++ ++I+ L A+L + + E EL L + + +KK+ + +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 525 TSIVQEEDPN-------EELSKD--EFILKLKAEVQRLLGSNSMKRHL-------VSQLQ 568
+ + ++ D E+ +D E + LK E++ L S + ++ L V+ L+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 569 NDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEI 628
L + + E Q + + + VE T+ E+ K + + L E+
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 629 QVLQQQNQELKETEGKLRNTNQDL---CN---QMRQMVQDFDHDKQEAVDRCERTYQQ-H 681
+VL Q QE++ + KL Q+L C+ + R + D H Q V+ +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 682 HEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKD 741
+A+K + L+ + Q+L + R L + ++L +L +E ++Q+ E K
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 742 NLE-----LTLRKTTEKEQ-----QTQEKIKE------KLIQQLEKEWQSKLDQTIKAMK 785
NLE L ++ + K++ T E ++E K I+ L ++++ K K K
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 786 KKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELEL 845
K D V D+ +++++ +E+++ Q L +EK+I+ K A ++ E E
Sbjct: 1421 TKNRLQQELDDLVV--DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 846 KHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSE 905
+ E TK + +A A + L EL ++KAE + + V K + + +
Sbjct: 1479 R--EKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNV-HELEK 1532
Query: 906 AKEKWKSELENMRKNILPGKELEEKIHSLQK---ELELKNEEVPVVIRAELAKARSEWNK 962
+K ++++E M+ + +ELE+++ + + LE+ + + +L +AR E N+
Sbjct: 1533 SKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNE 1588
Query: 963 EKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQ 1022
EK+ ++ R +Y L+D R K + AAAK+ +L LQ ++ ++
Sbjct: 1589 EKRRQLQR----QLHEYETELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIK----- 1638
Query: 1023 SRREWTMQEAKRIQLEIYQYEEDILTVLG----VLLSDTQKEHISDSEDKQLLEIMSTCS 1078
RE +++ +++Q ++ ++ ++ + + + E + S + L+++ +
Sbjct: 1639 -GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 1079 SKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKR---NMAELSKD-SASQGT--GQ 1132
+ + + + K + + +L NA + K+R +A+L ++ QG
Sbjct: 1698 AAERARKQADLEKEELAEELASSLS--GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 1133 GDPGPAAGHHAQPLA--LQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSL 1190
D A A+ L+ L + A++N ++L +N ++++KL E++ K+ +S
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 1191 SA 1192
A
Sbjct: 1816 IA 1817
Score = 104 bits (259), Expect = 8e-22
Identities = 180/896 (20%), Positives = 383/896 (42%), Gaps = 140/896 (15%)
Query: 240 QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKE 299
+L+ L + E + E++ + + QI L QL ++E L + N +
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 300 REIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQ---RAR 356
+ +LE I L+ + + + + K+ R LE+LK +L D S + Q RA+
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 357 EQHESIVMGL-----TKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEA 411
+ E V+ T+ +E QV +++ V L EQ + R K + L++N++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQT 1228
Query: 412 IKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQ 471
++ E ++ +L R L +++++ H + Q V +LQ + ++A A +N +
Sbjct: 1229 LEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARA---ELNDKVH 1283
Query: 472 EELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEE 531
+ E++ + A I + L+ +L ++ +L ++ K + T + Q E
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKLRQLE 1342
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQV------- 584
+ L +D+ +++A+ +++RH +S L L D KK++D
Sbjct: 1343 EERNSL-QDQLDEEMEAK-------QNLERH-ISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 585 -KKDEKSIEVETKT--------DTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQN 635
K+ +K IE T+ D EK KN+L E V D+ L + ++ Q++
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 636 QELKETEGKLRNTNQDLCNQMRQMVQDFD----------HDKQEAVDRCERTYQQHHEAM 685
+L E + + D ++ ++ + + EA + ERT ++ +
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT----NKML 1509
Query: 686 KTQIRESLLAK-------HALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCR 738
K ++ + + +K H LEK + A E +++++L++L E+ A ++ L R
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSK--RALETQMEEMKTQLEELEDELQATEDAKL---R 1564
Query: 739 EKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEK---EWQSKLD-----QTIKAMKKKTLD 790
+ N++ L+ E++ Q +++ E+ +QL++ E++++L+ + + A KK L+
Sbjct: 1565 LEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 791 CGSQTDQVTTSDVISKKEMAIM----IEEQKCTIQQNLEQ---EKDIAIKGAM------K 837
+ ++ I +E AI ++ Q Q+ LE +D A K
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 838 KLEIEL-----ELKHCENITKQVEI-----------------AVQNAHQRWLGELPELAE 875
LE +L +L E KQ ++ A+Q+ +R + +L E
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Query: 876 --------YQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKEL 927
+A+ +K ++ ++S + ++ E + +LE R+N KEL
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE--RQN----KEL 1797
Query: 928 EEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHR 987
K+H ++ ++ K + + A++A+ + +E +E+ + ++D
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--------- 1848
Query: 988 NKINEVLAAAKE-----DFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLE 1038
K+ E+L ++ + K++ E + +L+ L+++ E A R +L+
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 139 bits (349), Expect = 3e-32
Identities = 207/1022 (20%), Positives = 459/1022 (44%), Gaps = 114/1022 (11%)
Query: 236 MQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ 295
+Q+ + + +AKE +L+ E+ ++E +++ L + + +EK+ L L+ +L+
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 296 NGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRA 355
+E ++L A+ + LE + ++ E+ + + + + + QQ++DL
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-------- 963
Query: 356 REQHESIVMGLTKKYEEQVLSLQKNLDATVTA---LKEQEDICSRLKDHVKQLERNQEAI 412
++ EE+ + QK VTA +K+ ED + D +L + ++ +
Sbjct: 964 ------------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 413 KLEKTEIINKLTRSLEESQKQCAHLLQSGSVQE--VAQLQFQLQQAQKAHAMSANMNKAL 470
+ E I+ LT +L E +++ +L + + E +++L+ +L++ +K+ + + L
Sbjct: 1012 E----ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 471 QEELTELKDEIS-LYESAAKLGIHPSDSEGELNIELTE-----SYVDLGIKKVNWKKSKV 524
+ + ++ ++I+ L A+L + + E EL L + + +KK+ + +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 525 TSIVQEEDPN-------EELSKD--EFILKLKAEVQRLLGSNSMKRHL-------VSQLQ 568
+ + ++ D E+ +D E + LK E++ L S + ++ L V+ L+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 569 NDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEI 628
L + + E Q + + + VE T+ E+ K + + L E+
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 629 QVLQQQNQELKETEGKLRNTNQDL---CN---QMRQMVQDFDHDKQEAVDRCERTYQQ-H 681
+VL Q QE++ + KL Q+L C+ + R + D H Q V+ +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 682 HEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKD 741
+A+K + L+ + Q+L + R L + ++L +L +E ++Q+ E K
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 742 NLE-----LTLRKTTEKEQ-----QTQEKIKE------KLIQQLEKEWQSKLDQTIKAMK 785
NLE L ++ + K++ T E ++E K I+ L ++++ K K K
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 786 KKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELEL 845
K D V D+ +++++ +E+++ Q L +EK+I+ K A ++ E E
Sbjct: 1428 TKNRLQQELDDLVV--DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 846 KHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSE 905
+ E TK + +A A + L EL ++KAE + + V K + + +
Sbjct: 1486 R--EKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNV-HELEK 1539
Query: 906 AKEKWKSELENMRKNILPGKELEEKIHSLQK---ELELKNEEVPVVIRAELAKARSEWNK 962
+K ++++E M+ + +ELE+++ + + LE+ + + +L +AR E N+
Sbjct: 1540 SKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNE 1595
Query: 963 EKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQ 1022
EK+ ++ R +Y L+D R K + AAAK+ +L LQ ++ ++
Sbjct: 1596 EKRRQLQR----QLHEYETELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIK----- 1645
Query: 1023 SRREWTMQEAKRIQLEIYQYEEDILTVLG----VLLSDTQKEHISDSEDKQLLEIMSTCS 1078
RE +++ +++Q ++ ++ ++ + + + E + S + L+++ +
Sbjct: 1646 -GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 1079 SKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKR---NMAELSKD-SASQGT--GQ 1132
+ + + + K + + +L NA + K+R +A+L ++ QG
Sbjct: 1705 AAERARKQADLEKEELAEELASSLS--GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 1133 GDPGPAAGHHAQPLA--LQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSL 1190
D A A+ L+ L + A++N ++L +N ++++KL E++ K+ +S
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 1191 SA 1192
A
Sbjct: 1823 IA 1824
Score = 104 bits (259), Expect = 8e-22
Identities = 180/896 (20%), Positives = 383/896 (42%), Gaps = 140/896 (15%)
Query: 240 QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKE 299
+L+ L + E + E++ + + QI L QL ++E L + N +
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 300 REIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQ---RAR 356
+ +LE I L+ + + + + K+ R LE+LK +L D S + Q RA+
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 357 EQHESIVMGL-----TKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEA 411
+ E V+ T+ +E QV +++ V L EQ + R K + L++N++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQT 1235
Query: 412 IKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQ 471
++ E ++ +L R L +++++ H + Q V +LQ + ++A A +N +
Sbjct: 1236 LEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARA---ELNDKVH 1290
Query: 472 EELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEE 531
+ E++ + A I + L+ +L ++ +L ++ K + T + Q E
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKLRQLE 1349
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQV------- 584
+ L +D+ +++A+ +++RH +S L L D KK++D
Sbjct: 1350 EERNSL-QDQLDEEMEAK-------QNLERH-ISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 585 -KKDEKSIEVETKT--------DTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQN 635
K+ +K IE T+ D EK KN+L E V D+ L + ++ Q++
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 636 QELKETEGKLRNTNQDLCNQMRQMVQDFD----------HDKQEAVDRCERTYQQHHEAM 685
+L E + + D ++ ++ + + EA + ERT ++ +
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT----NKML 1516
Query: 686 KTQIRESLLAK-------HALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCR 738
K ++ + + +K H LEK + A E +++++L++L E+ A ++ L R
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSK--RALETQMEEMKTQLEELEDELQATEDAKL---R 1571
Query: 739 EKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEK---EWQSKLD-----QTIKAMKKKTLD 790
+ N++ L+ E++ Q +++ E+ +QL++ E++++L+ + + A KK L+
Sbjct: 1572 LEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 791 CGSQTDQVTTSDVISKKEMAIM----IEEQKCTIQQNLEQ---EKDIAIKGAM------K 837
+ ++ I +E AI ++ Q Q+ LE +D A K
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 838 KLEIEL-----ELKHCENITKQVEI-----------------AVQNAHQRWLGELPELAE 875
LE +L +L E KQ ++ A+Q+ +R + +L E
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Query: 876 --------YQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKEL 927
+A+ +K ++ ++S + ++ E + +LE R+N KEL
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE--RQN----KEL 1804
Query: 928 EEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHR 987
K+H ++ ++ K + + A++A+ + +E +E+ + ++D
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--------- 1855
Query: 988 NKINEVLAAAKE-----DFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLE 1038
K+ E+L ++ + K++ E + +L+ L+++ E A R +L+
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 139 bits (349), Expect = 3e-32
Identities = 207/1022 (20%), Positives = 459/1022 (44%), Gaps = 114/1022 (11%)
Query: 236 MQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ 295
+Q+ + + +AKE +L+ E+ ++E +++ L + + +EK+ L L+ +L+
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 296 NGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRA 355
+E ++L A+ + LE + ++ E+ + + + + + QQ++DL
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-------- 963
Query: 356 REQHESIVMGLTKKYEEQVLSLQKNLDATVTA---LKEQEDICSRLKDHVKQLERNQEAI 412
++ EE+ + QK VTA +K+ ED + D +L + ++ +
Sbjct: 964 ------------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 413 KLEKTEIINKLTRSLEESQKQCAHLLQSGSVQE--VAQLQFQLQQAQKAHAMSANMNKAL 470
+ E I+ LT +L E +++ +L + + E +++L+ +L++ +K+ + + L
Sbjct: 1012 E----ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 471 QEELTELKDEIS-LYESAAKLGIHPSDSEGELNIELTE-----SYVDLGIKKVNWKKSKV 524
+ + ++ ++I+ L A+L + + E EL L + + +KK+ + +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 525 TSIVQEEDPN-------EELSKD--EFILKLKAEVQRLLGSNSMKRHL-------VSQLQ 568
+ + ++ D E+ +D E + LK E++ L S + ++ L V+ L+
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 569 NDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEI 628
L + + E Q + + + VE T+ E+ K + + L E+
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 629 QVLQQQNQELKETEGKLRNTNQDL---CN---QMRQMVQDFDHDKQEAVDRCERTYQQ-H 681
+VL Q QE++ + KL Q+L C+ + R + D H Q V+ +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 682 HEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKD 741
+A+K + L+ + Q+L + R L + ++L +L +E ++Q+ E K
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 742 NLE-----LTLRKTTEKEQ-----QTQEKIKE------KLIQQLEKEWQSKLDQTIKAMK 785
NLE L ++ + K++ T E ++E K I+ L ++++ K K K
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 786 KKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELEL 845
K D V D+ +++++ +E+++ Q L +EK+I+ K A ++ E E
Sbjct: 1428 TKNRLQQELDDLVV--DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 846 KHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSE 905
+ E TK + +A A + L EL ++KAE + + V K + + +
Sbjct: 1486 R--EKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNV-HELEK 1539
Query: 906 AKEKWKSELENMRKNILPGKELEEKIHSLQK---ELELKNEEVPVVIRAELAKARSEWNK 962
+K ++++E M+ + +ELE+++ + + LE+ + + +L +AR E N+
Sbjct: 1540 SKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNE 1595
Query: 963 EKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQ 1022
EK+ ++ R +Y L+D R K + AAAK+ +L LQ ++ ++
Sbjct: 1596 EKRRQLQR----QLHEYETELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIK----- 1645
Query: 1023 SRREWTMQEAKRIQLEIYQYEEDILTVLG----VLLSDTQKEHISDSEDKQLLEIMSTCS 1078
RE +++ +++Q ++ ++ ++ + + + E + S + L+++ +
Sbjct: 1646 -GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 1079 SKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKR---NMAELSKD-SASQGT--GQ 1132
+ + + + K + + +L NA + K+R +A+L ++ QG
Sbjct: 1705 AAERARKQADLEKEELAEELASSLS--GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 1133 GDPGPAAGHHAQPLA--LQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSL 1190
D A A+ L+ L + A++N ++L +N ++++KL E++ K+ +S
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 1191 SA 1192
A
Sbjct: 1823 IA 1824
Score = 104 bits (259), Expect = 8e-22
Identities = 180/896 (20%), Positives = 383/896 (42%), Gaps = 140/896 (15%)
Query: 240 QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKE 299
+L+ L + E + E++ + + QI L QL ++E L + N +
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 300 REIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQ---RAR 356
+ +LE I L+ + + + + K+ R LE+LK +L D S + Q RA+
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 357 EQHESIVMGL-----TKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEA 411
+ E V+ T+ +E QV +++ V L EQ + R K + L++N++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQT 1235
Query: 412 IKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQ 471
++ E ++ +L R L +++++ H + Q V +LQ + ++A A +N +
Sbjct: 1236 LEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARA---ELNDKVH 1290
Query: 472 EELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEE 531
+ E++ + A I + L+ +L ++ +L ++ K + T + Q E
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKLRQLE 1349
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQV------- 584
+ L +D+ +++A+ +++RH +S L L D KK++D
Sbjct: 1350 EERNSL-QDQLDEEMEAK-------QNLERH-ISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 585 -KKDEKSIEVETKT--------DTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQN 635
K+ +K IE T+ D EK KN+L E V D+ L + ++ Q++
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 636 QELKETEGKLRNTNQDLCNQMRQMVQDFD----------HDKQEAVDRCERTYQQHHEAM 685
+L E + + D ++ ++ + + EA + ERT ++ +
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT----NKML 1516
Query: 686 KTQIRESLLAK-------HALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCR 738
K ++ + + +K H LEK + A E +++++L++L E+ A ++ L R
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSK--RALETQMEEMKTQLEELEDELQATEDAKL---R 1571
Query: 739 EKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEK---EWQSKLD-----QTIKAMKKKTLD 790
+ N++ L+ E++ Q +++ E+ +QL++ E++++L+ + + A KK L+
Sbjct: 1572 LEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 791 CGSQTDQVTTSDVISKKEMAIM----IEEQKCTIQQNLEQ---EKDIAIKGAM------K 837
+ ++ I +E AI ++ Q Q+ LE +D A K
Sbjct: 1631 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Query: 838 KLEIEL-----ELKHCENITKQVEI-----------------AVQNAHQRWLGELPELAE 875
LE +L +L E KQ ++ A+Q+ +R + +L E
Sbjct: 1691 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750
Query: 876 --------YQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKEL 927
+A+ +K ++ ++S + ++ E + +LE R+N KEL
Sbjct: 1751 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE--RQN----KEL 1804
Query: 928 EEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHR 987
K+H ++ ++ K + + A++A+ + +E +E+ + ++D
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--------- 1855
Query: 988 NKINEVLAAAKE-----DFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLE 1038
K+ E+L ++ + K++ E + +L+ L+++ E A R +L+
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 139 bits (349), Expect = 3e-32
Identities = 207/1022 (20%), Positives = 459/1022 (44%), Gaps = 114/1022 (11%)
Query: 236 MQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ 295
+Q+ + + +AKE +L+ E+ ++E +++ L + + +EK+ L L+ +L+
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 296 NGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRA 355
+E ++L A+ + LE + ++ E+ + + + + + QQ++DL
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-------- 956
Query: 356 REQHESIVMGLTKKYEEQVLSLQKNLDATVTA---LKEQEDICSRLKDHVKQLERNQEAI 412
++ EE+ + QK VTA +K+ ED + D +L + ++ +
Sbjct: 957 ------------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 413 KLEKTEIINKLTRSLEESQKQCAHLLQSGSVQE--VAQLQFQLQQAQKAHAMSANMNKAL 470
+ E I+ LT +L E +++ +L + + E +++L+ +L++ +K+ + + L
Sbjct: 1005 E----ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 471 QEELTELKDEIS-LYESAAKLGIHPSDSEGELNIELTE-----SYVDLGIKKVNWKKSKV 524
+ + ++ ++I+ L A+L + + E EL L + + +KK+ + +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 525 TSIVQEEDPN-------EELSKD--EFILKLKAEVQRLLGSNSMKRHL-------VSQLQ 568
+ + ++ D E+ +D E + LK E++ L S + ++ L V+ L+
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 569 NDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEI 628
L + + E Q + + + VE T+ E+ K + + L E+
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 629 QVLQQQNQELKETEGKLRNTNQDL---CN---QMRQMVQDFDHDKQEAVDRCERTYQQ-H 681
+VL Q QE++ + KL Q+L C+ + R + D H Q V+ +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 682 HEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKD 741
+A+K + L+ + Q+L + R L + ++L +L +E ++Q+ E K
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 742 NLE-----LTLRKTTEKEQ-----QTQEKIKE------KLIQQLEKEWQSKLDQTIKAMK 785
NLE L ++ + K++ T E ++E K I+ L ++++ K K K
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 786 KKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELEL 845
K D V D+ +++++ +E+++ Q L +EK+I+ K A ++ E E
Sbjct: 1421 TKNRLQQELDDLVV--DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 846 KHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSE 905
+ E TK + +A A + L EL ++KAE + + V K + + +
Sbjct: 1479 R--EKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNV-HELEK 1532
Query: 906 AKEKWKSELENMRKNILPGKELEEKIHSLQK---ELELKNEEVPVVIRAELAKARSEWNK 962
+K ++++E M+ + +ELE+++ + + LE+ + + +L +AR E N+
Sbjct: 1533 SKRALETQMEEMKTQL---EELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNE 1588
Query: 963 EKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQ 1022
EK+ ++ R +Y L+D R K + AAAK+ +L LQ ++ ++
Sbjct: 1589 EKRRQLQR----QLHEYETELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIK----- 1638
Query: 1023 SRREWTMQEAKRIQLEIYQYEEDILTVLG----VLLSDTQKEHISDSEDKQLLEIMSTCS 1078
RE +++ +++Q ++ ++ ++ + + + E + S + L+++ +
Sbjct: 1639 -GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 1079 SKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKR---NMAELSKD-SASQGT--GQ 1132
+ + + + K + + +L NA + K+R +A+L ++ QG
Sbjct: 1698 AAERARKQADLEKEELAEELASSLS--GRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 1133 GDPGPAAGHHAQPLA--LQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSL 1190
D A A+ L+ L + A++N ++L +N ++++KL E++ K+ +S
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 1191 SA 1192
A
Sbjct: 1816 IA 1817
Score = 104 bits (259), Expect = 8e-22
Identities = 180/896 (20%), Positives = 383/896 (42%), Gaps = 140/896 (15%)
Query: 240 QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKE 299
+L+ L + E + E++ + + QI L QL ++E L + N +
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 300 REIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQ---RAR 356
+ +LE I L+ + + + + K+ R LE+LK +L D S + Q RA+
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 357 EQHESIVMGL-----TKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEA 411
+ E V+ T+ +E QV +++ V L EQ + R K + L++N++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN---LDKNKQT 1228
Query: 412 IKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQ 471
++ E ++ +L R L +++++ H + Q V +LQ + ++A A +N +
Sbjct: 1229 LEKENADLAGEL-RVLGQAKQEVEHKKKKLEAQ-VQELQSKCSDGERARA---ELNDKVH 1283
Query: 472 EELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEE 531
+ E++ + A I + L+ +L ++ +L ++ K + T + Q E
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ-ELLQEETRQKLNVSTKLRQLE 1342
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQV------- 584
+ L +D+ +++A+ +++RH +S L L D KK++D
Sbjct: 1343 EERNSL-QDQLDEEMEAK-------QNLERH-ISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 585 -KKDEKSIEVETKT--------DTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQN 635
K+ +K IE T+ D EK KN+L E V D+ L + ++ Q++
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 636 QELKETEGKLRNTNQDLCNQMRQMVQDFD----------HDKQEAVDRCERTYQQHHEAM 685
+L E + + D ++ ++ + + EA + ERT ++ +
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT----NKML 1509
Query: 686 KTQIRESLLAK-------HALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCR 738
K ++ + + +K H LEK + A E +++++L++L E+ A ++ L R
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSK--RALETQMEEMKTQLEELEDELQATEDAKL---R 1564
Query: 739 EKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEK---EWQSKLD-----QTIKAMKKKTLD 790
+ N++ L+ E++ Q +++ E+ +QL++ E++++L+ + + A KK L+
Sbjct: 1565 LEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 791 CGSQTDQVTTSDVISKKEMAIM----IEEQKCTIQQNLEQ---EKDIAIKGAM------K 837
+ ++ I +E AI ++ Q Q+ LE +D A K
Sbjct: 1624 GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Query: 838 KLEIEL-----ELKHCENITKQVEI-----------------AVQNAHQRWLGELPELAE 875
LE +L +L E KQ ++ A+Q+ +R + +L E
Sbjct: 1684 SLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743
Query: 876 --------YQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKEL 927
+A+ +K ++ ++S + ++ E + +LE R+N KEL
Sbjct: 1744 ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE--RQN----KEL 1797
Query: 928 EEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHR 987
K+H ++ ++ K + + A++A+ + +E +E+ + ++D
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--------- 1848
Query: 988 NKINEVLAAAKE-----DFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLE 1038
K+ E+L ++ + K++ E + +L+ L+++ E A R +L+
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 127 bits (320), Expect = 7e-29
Identities = 249/1198 (20%), Positives = 507/1198 (42%), Gaps = 170/1198 (14%)
Query: 236 MQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ 295
+Q+ + + +AK+ +L + EK + E ++ + + + +EK+ L L+ +LF
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 296 NGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHH---SESL 352
+E +L A+ + LE + L+ E+ ++++ + + ++ + DL E
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 353 QRAREQHESIVM-GLTKKYEEQVLSLQKNLDATVTALKEQED---ICSRLKDHVKQLERN 408
R + Q E + KK EE++L L+ + K ED CS ++ +N
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 409 QEAIKLEKTEIINKLTRSLEESQKQCAHLLQ---------SGSVQEVAQLQFQLQQAQKA 459
I+ ++ +I+ L L++ +K L + + ++A+LQ Q+ + +
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK-- 1082
Query: 460 HAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNW 519
A + LQ L DE +A K+ EL ++ E D +K +
Sbjct: 1083 -LQLAKKEEELQGALARGDDETLHKNNALKV-------VRELQAQIAELQEDFESEKASR 1134
Query: 520 KKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIE 579
K++ Q+ D +EEL LK E++ L + + ++ L ++ + ++ + K +E
Sbjct: 1135 NKAE----KQKRDLSEELE------ALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 580 DLHQVKKDEKSIE---------VETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQV 630
+ + K E I+ +E ++ E+ K + D L E++V
Sbjct: 1185 E--ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 631 LQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQ-------HHE 683
LQQ E + KL Q+L V + D + E ++ + + E
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQEL----HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 684 AMKTQIR----ESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCRE 739
A K I+ + L + Q+L + R L L S + +L +E ++QE E
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 740 KDNLELTLRKTTEKEQQTQEKIKEKL--IQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQ 797
+ NLE + + T++K+ + L I+ LE E + KL + +A+ ++ + D+
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLE-EAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 798 V-------------TTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELE 844
+ T D+ ++++A +E+++ Q L +EK I+ + A ++ E E
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477
Query: 845 LKHCE----NITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 900
+ E ++ + +E A++ + A+ + L+ ++ + HE+ +KR
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR-- 1535
Query: 901 FAVSEAKEKWKSELENMRKNILPGKE----LEEKIHSLQKELEL-------KNEEVPVVI 949
A+ + E+ +++LE + + ++ LE + +++ + E +NEE ++
Sbjct: 1536 -ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 950 RAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELL 1009
++ + +E E+++ + + + + L D +I E A+++ +KQ +L
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEID--LKDLEAQI-EAANKARDEVIKQLRKLQ 1651
Query: 1010 LQKETELQTCLDQSR--REWTMQEAKRIQLEIYQYEEDILTVLGVLL-SDTQKEHISDSE 1066
Q + + Q L+++R R+ ++K + ++ E +IL + L S+ + H
Sbjct: 1652 AQMK-DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Query: 1067 DKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSA 1126
D+ EI ++ S K + +L+ I + ++ E ++ NM EL D
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEEL----------EEEQSNM-ELLNDRF 1759
Query: 1127 SQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTP 1186
+ T Q D A L A + A++++ ++L +N ++K KL+EL+ K+
Sbjct: 1760 RKTTLQVDTLNA--------ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811
Query: 1187 PRSLSAGAIENACLPCSGGALEELRGQYIK-----------AVKKIKCDMLRYIQESKER 1235
++ + L G LEE Q K KK+K ++ +++ +
Sbjct: 1812 FKATI------SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK-EIFMQVEDERRH 1864
Query: 1236 A----AEMVKAEV--------LRERQETARK----MRKYYLICLQQILQD--DGKEGAEK 1277
A +M KA L E +E A + RK LQ+ L D + EG +
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK-----LQRELDDATEANEGLSR 1919
Query: 1278 KIMNAASKLATMAKLLETPIS-SKSQSKTTQSALPLTS-EMLIAVKKSKRNDVNQKIP 1333
++ ++L PIS S S+S Q L S E+ +SK +DVN+ P
Sbjct: 1920 EVSTLKNRLRRGG-----PISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQP 1972
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 124 bits (310), Expect = 1e-27
Identities = 265/1210 (21%), Positives = 486/1210 (40%), Gaps = 201/1210 (16%)
Query: 266 IRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQM 325
+ + QL I+ EK L L + + E QL+ QI +I++LK +
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 326 IKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATV 385
+ + + LES + Q+ L H LQ ++ + ++ K EE V L L
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI----SKKEEDVSYLSGQLSEKE 1419
Query: 386 TALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQE 445
AL + + +D +K L E E E I +L L E +++ + + ++
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 446 VAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIEL 505
Q+Q +LQ A + + NK+LQEEL+ + I +L +D E +++ +
Sbjct: 1480 --QIQRKLQAALISRKEALKENKSLQEELSLARGTIE------RLTKSLADVESQVSAQN 1531
Query: 506 TESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVS 565
E LG +++QEE D +L E Q L S + +
Sbjct: 1532 KEKDTVLGR----------LALLQEERDKLITEMDRSLL----ENQSLSSSCESLKLALE 1577
Query: 566 QLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESS----TSDVVRDDI 621
L D + K+IE L KS ++ T+ EK K +L E + + V ++
Sbjct: 1578 GLTEDKEKLVKEIESL-------KSSKIAESTEWQEKHK-ELQKEYEILLQSYENVSNEA 1629
Query: 622 LLLKNEIQVLQQQNQEL-----------KETEGKLRNTNQDLCNQMRQMVQDFDHDKQEA 670
+++ ++ ++Q+ QEL KETE +L+ Q++ +M++ ++ F KQ+
Sbjct: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEM-EEMKEKMRKFAKSKQQK 1688
Query: 671 V----DRCERTYQQHHEAMKT--QIRESLLAKHALEKQQL------FEAYERTHLQLRSE 718
+ + +R + H A T + E+LL+ +A K++L +E + L SE
Sbjct: 1689 ILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE 1748
Query: 719 LDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQL--EKEWQSK 776
D L++EV ++ ++ NLE T ++ Q + E+ Q + E E Q
Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEAT------EKHDNQTNVTEEGTQSIPGETEEQDS 1802
Query: 777 LDQTIKAMKKKTLDCGSQTDQVTTSDVISK-------------KEMAIMIEEQKCT---I 820
L + + +++ + + D S KE +EE+K
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF 1862
Query: 821 QQNLEQEKDIAIK------GAMKKLEIEL------------ELKHCENITKQVEIAVQNA 862
Q LE EK+ + G +K L+ E+ EL + + E +
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL 1922
Query: 863 HQRWLGELPEL----AEYQALVKAEQKKWE--EQHEVSVNKRISFAVSE----AKEKWKS 912
+R + +L EL Y V Q K E E ++ K +S E KEK K
Sbjct: 1923 EERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV 1982
Query: 913 ELENMRKNIL---------PG------------KELEEKIHSLQKELELKNEEVPVVIRA 951
E E +RK L PG KE ++++ LQK+ E++ + R
Sbjct: 1983 ESE-IRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT 2041
Query: 952 ELAKARSEWNKEKQEEI----------HRIQEQNE-QDYRQFLDDHRNKINEVLAAAKED 1000
A + +K EI HR + Q E ++ LDD +++ VLA D
Sbjct: 2042 VKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA----D 2097
Query: 1001 FMKQKTEL----------LLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVL 1050
+K K EL + QK+ +L+ L+Q+ E ++E K +Q ++ D L
Sbjct: 2098 NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE-EKHLKEKKNMQEKL-----DALRRE 2151
Query: 1051 GVLLSDT--QKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQ----------KAF 1098
V L +T + + + +DK++ ++ S + F K +Q K +
Sbjct: 2152 KVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW 2211
Query: 1099 QDTLPLLVENADPEWK-KRNMAELSKDSASQGTGQGDP---GPAAGHHAQPLALQATEAE 1154
+ +++ + E + K + + KD Q + + + H + + + E
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Query: 1155 AEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCS----GGALE-- 1208
+ KV + L EN ++ ++LEE + L + L+ E L +LE
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331
Query: 1209 -ELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQIL 1267
E +G +++ + D IQ SK + E ++ ++ R+ T+R + + + I
Sbjct: 2332 KEQKGNLEGIIRQQEAD----IQNSK-FSYEQLETDLQASRELTSRLHEEINMKEQKIIS 2386
Query: 1268 QDDGKEGA-EKKIMNAASKLATMAKLLETPISSKSQ-----SKTTQSALPLTSEMLIAVK 1321
GKE A + I + K LE +S + + + + A+ T++++ +K
Sbjct: 2387 LLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLK 2446
Query: 1322 KSKRNDVNQK 1331
K+ ++ QK
Sbjct: 2447 TIKKENIQQK 2456
Score = 116 bits (291), Expect = 2e-25
Identities = 216/993 (21%), Positives = 413/993 (41%), Gaps = 140/993 (14%)
Query: 223 QQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDG 282
Q+ + A E + + ++ +Q + K E ENL + + ++ L V++ D +
Sbjct: 2032 QEKISALERTVKALEFVQTES-QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSE 2090
Query: 283 LTLSLRESQKLFQNGKEREIQLEAQIKALETQIQA-LKVNEEQMIKKSRTTEMALESLKQ 341
L ++ KL + + + +++Q+K + ++ L+ EE+ +K+ + + L++L++
Sbjct: 2091 AARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRR 2150
Query: 342 QLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVT-------ALKEQEDI 394
+ V L E I + L KK +++V LQ+NLD+TVT ++ +D
Sbjct: 2151 EKVHLE---------ETIGEIQVTLNKK-DKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
Query: 395 CSRLKDHVKQLERN-QEAIKLEKTEI-------------INKLTRSLEESQKQCAHLLQS 440
R+ D K+ ER +AI+ ++ EI + +++ +EE + + L
Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD 2260
Query: 441 GSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGE 500
+ E ++ Q ++Q QK NK L L++L++ LY S+ + E E
Sbjct: 2261 KQIWE-SKAQTEVQLQQKVCDTLQGENKEL---LSQLEETRHLYHSSQN---ELAKLESE 2313
Query: 501 LNIELTESYVDL--GIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNS 558
L L + DL ++K +K + I+++++ + + SK + +L+ ++Q
Sbjct: 2314 LK-SLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY-EQLETDLQ------- 2364
Query: 559 MKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVR 618
R L S+L ++ +KI L K++ + + +K +L E+ S
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKEL--ENLLSQEEE 2422
Query: 619 DDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTY 678
++I+L + + + + NQ L ET ++ N Q+ V+ Q DR Y
Sbjct: 2423 ENIVLEEENKKAVDKTNQ-LMETLKTIKKENIQQKAQLDSFVKSMS-SLQNDRDRIVGDY 2480
Query: 679 QQHHEAMKTQI--RESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEV 736
QQ E + I ++ L+ + A E +L E LRS +D LN E A + L
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIR----GLRSHMDDLNSE-NAKLDAELIQ 2535
Query: 737 CREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTD 796
RE N +T+ K ++++Q + ++++ ++LE ++ +KL++ +K ++ D +
Sbjct: 2536 YREDLNQVITI-KDSQQKQLLEVQLQQN--KELENKY-AKLEEKLKESEEANEDLRRSFN 2591
Query: 797 QVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVE 856
+ K++++ IE K +I Q Q + +G + +L++K
Sbjct: 2592 ALQE----EKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE--------- 2638
Query: 857 IAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHE--VSVNKRISFAVSEAKEKWKSEL 914
E+ AL + QK+ E E V V K + V E ++K K EL
Sbjct: 2639 --------------EEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL 2684
Query: 915 ENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKE-----KQEEIH 969
K L ++ E E E V AELA+ E ++ K+ +
Sbjct: 2685 ----------KHLHHDAGIMRNETETAEERV-----AELARDLVEMEQKLLMVTKENKGL 2729
Query: 970 RIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTM 1029
Q Q+ L + R+ NE L K + EL KE Q L++ R
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE---QGLLNRERDALLS 2786
Query: 1030 QEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEK 1089
+ A + EE+ L+ L L S+D+QLL + S + VQ F K
Sbjct: 2787 ETA----FSMNSTEENSLSHLEKLNQQLL------SKDEQLLHLSSQLEDSYNQVQSFSK 2836
Query: 1090 LKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQ 1149
+Q D W + S++ + Q PA + A+
Sbjct: 2837 AMASLQ-----------NERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK-AMS 2884
Query: 1150 ATEAEAEENNKVVEELIEENNDMKNKLEELQTL 1182
+ + + + K ++ L ++ + ++ EL L
Sbjct: 2885 SLQNDRDRLLKELKNLQQQYLQINQEITELHPL 2917
Score = 107 bits (266), Expect = 1e-22
Identities = 233/1186 (19%), Positives = 495/1186 (41%), Gaps = 188/1186 (15%)
Query: 221 LQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQ-------L 273
LQ + E EN + + L + +E L + L + E Q+ N + L
Sbjct: 1485 LQAALISRKEALKENKSLQEELSLARGT---IERLTKSLADVESQVSAQNKEKDTVLGRL 1541
Query: 274 VIIKDEKDGLTL----SLRESQKLFQNGKEREIQLEAQIKALETQIQALK-VNEEQMIKK 328
++++E+D L SL E+Q L + + ++ LE + E ++ ++ + ++ +
Sbjct: 1542 ALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601
Query: 329 SRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEE---QVLSLQKNLDATV 385
+ E E K+ + L E++ E+ + +V + ++ +E ++ S + N T
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661
Query: 386 TALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLE---ESQKQCAHLLQSGS 442
L+E E +K+ +++ ++++ LE E ++L + ++ K+C L S +
Sbjct: 1662 KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721
Query: 443 V---QEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEG 499
+E+ +++ + + K + +L EE+ +LK +I +
Sbjct: 1722 ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE------------GNVSK 1769
Query: 500 ELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSM 559
+ N+E TE + + ++ VT + P E +D + + + S
Sbjct: 1770 QANLEATEKHDN---------QTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKS 1820
Query: 560 KRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETK-----TDTSEKPKNQLWPESSTS 614
VS+ + + + ++ + Q+K+ +E E + + T E KN L + ST
Sbjct: 1821 ANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTK 1880
Query: 615 DVVRDDILLLKNEIQVLQQQNQELKETEG---KLRNTNQD--------LCNQMRQMVQDF 663
D ++ +L+ E+ + NQ+++E KL+ T ++ L NQ+ ++
Sbjct: 1881 D---GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937
Query: 664 DHDKQEAVD----------------RCERTYQQHHEAM---KTQIRESLLAKHALEKQQ- 703
+ Q+ D +C ++ + + KT++ ES + K LEK Q
Sbjct: 1938 GNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV-ESEIRKEYLEKIQG 1996
Query: 704 -LFEAYERTHL-QLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKI 761
E ++H +L+ L + +EV +Q+ + + LE T++ + ++Q+ +
Sbjct: 1997 AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDL 2056
Query: 762 ---KEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKC 818
KE L Q +E + K + + K D S+ +V ++ KKE+ E K
Sbjct: 2057 EITKENLAQAVEH--RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114
Query: 819 TIQQN-------LEQEKDIAIK---GAMKKLE-IELELKHCENITKQVEIA-------VQ 860
++Q LEQ ++ +K +KL+ + E H E ++++ VQ
Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQ 2174
Query: 861 NAHQRWLGELPELAEYQALVKA----------EQKKWEEQHEVSVNKRISFAVSEAKEKW 910
+ + +LA + + + E KKWE ++ S A+ +E+
Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE--------RKFSDAIQSKEEEI 2226
Query: 911 KSELEN-------MRKNILPGKELEEKIHSLQKELEL--KNEEVPVVIRAELAKARSEWN 961
+ + +N +R+ + +EL+ I L+ + ++ + V ++ ++ N
Sbjct: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 962 KE---KQEEIHRIQEQNEQDYRQFLDDHRNKINEV--LAAAKEDFMKQKTEL---LLQKE 1013
KE + EE + ++ + + + ++ +++ L+ + E +QK L + Q+E
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
Query: 1014 TELQTC-LDQSRREWTMQEAK----RIQLEIYQYEEDILTVLG-------VLLSDTQKEH 1061
++Q + E +Q ++ R+ EI E+ I+++L V +++ +++H
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406
Query: 1062 ISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQ--DTLPLLVENADPEWKKRNM- 1118
D E K+L ++S + + ++ E+ K + K Q +TL + KK N+
Sbjct: 2407 --DKEIKELENLLSQEEEENIVLE--EENKKAVDKTNQLMETLKTI--------KKENIQ 2454
Query: 1119 --AELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAE-ENNKVVEELIEENNDMKNK 1175
A+L S + Q D G + Q L+ E +++++E ENN +K +
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRDRIVGDYQQ---LEERHLSIILEKDQLIQEAAAENNKLKEE 2511
Query: 1176 LEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRY-IQESKE 1234
+ L++ + ENA L E Q I + +L +Q++KE
Sbjct: 2512 IRGLRS-------HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE 2564
Query: 1235 RAAEMVKAEV-LRERQETARKMRKYYLICLQQILQDDGKEGAEKKI 1279
+ K E L+E +E +R+ + LQ+ QD KE K+
Sbjct: 2565 LENKYAKLEEKLKESEEANEDLRRSFN-ALQEEKQDLSKEIESLKV 2609
Score = 101 bits (251), Expect = 7e-21
Identities = 236/1169 (20%), Positives = 451/1169 (38%), Gaps = 228/1169 (19%)
Query: 248 KERQLENLIEKLNESERQIRYLNHQL------------------VIIK---DEKDGLTLS 286
+E ++E + KL E E I L QL V++K EK+ +
Sbjct: 142 EEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIST 201
Query: 287 L-------RESQKLFQNGKEREIQLEAQIKALETQIQALKVN---EEQMIKKSRTTEMAL 336
L + Q Q +E++ + E Q++ E ++ L E +M +K R + L
Sbjct: 202 LQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKL 261
Query: 337 ESLKQ------QLVDLHH-------------SESLQRAREQHESIVMGLTKKYEEQVLSL 377
E ++ Q+VDL S+ LQ+ +H ++ + + EE + L
Sbjct: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
Query: 378 QK-------------NLDATVTALKEQEDIC----SRLKDHVKQLERNQEAIKLEKTEII 420
+K NL + L EQ + + L+ LE+ +A EKT I
Sbjct: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 381
Query: 421 NKLTRSLEESQKQC-------AHLLQS------GSVQEVAQLQFQLQQAQKAHAMSANMN 467
L ++ +E Q C + LLQ S Q + QL+ QLQQ K + N
Sbjct: 382 LSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL 441
Query: 468 KALQEELTELKDEISLY---------ESAAKLGIHPSDSEGELNIELTESYVDLGIKKVN 518
Q E +Y E+ A L + E E L S +K N
Sbjct: 442 PLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAEN 501
Query: 519 WKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKI 578
K S ++++ ++ E ++ + + + S+S + L+N HK++
Sbjct: 502 EKLSSQITLLEAQNRTGEADREVSEISIVDIANK--RSSSAEESGQDVLENTFSQKHKEL 559
Query: 579 E----DLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDV----------------VR 618
++ + +++ ++++ + +E+ +++ + +
Sbjct: 560 SVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTG 619
Query: 619 DDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCN----QMRQMVQDFDHDKQEAVDRC 674
D L+ NE L +E TE + R + + N +++ QD D AV
Sbjct: 620 QDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGD-KSLSAVPDI 678
Query: 675 ERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYL 734
+ +Q E +K+QI E L H + E YE+ LD+ KE++ + +
Sbjct: 679 GQCHQDELERLKSQILELELNFHKAQ-----EIYEK-------NLDEKAKEISNLNQLIE 726
Query: 735 EVCREKDNLELTLRKTTEKEQQTQEKIKE-KLIQQLEKEWQSKLDQTIKAMKKKTLDCGS 793
E + DN +E+ Q ++KE ++ +L + + +A +++ LD S
Sbjct: 727 EFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYES 786
Query: 794 QT--DQVTTSDV----ISKKEMAIMIE--------------EQKC---TIQQNLEQEKDI 830
QT D + T + I K + IE EQ ++Q L+ ++
Sbjct: 787 QTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE 846
Query: 831 AIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQ 890
++GA + I +++ Q E+ + Q L + ++ Q ++ + ++ E
Sbjct: 847 VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTE- 905
Query: 891 HEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIR 950
ISF+++E +L E+ SL E++ E++ ++ R
Sbjct: 906 --------ISFSMTEKM-----------------VQLNEEKFSLGVEIKTLKEQLNLLSR 940
Query: 951 AELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLL 1010
AE AK KE+ EE + + +Q+Y + +I++ + D +K++ E
Sbjct: 941 AEEAK------KEQVEEDNEVSSGLKQNYDEM--SPAGQISKEELQHEFDLLKKENE--- 989
Query: 1011 QKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQL 1070
Q++ +LQ L R+ +Q R++ E+ +++ + + LS+T++ + EDK+
Sbjct: 990 QRKRKLQAAL--INRKELLQRVSRLEEELANLKDE--SKKEIPLSETERGEV--EEDKEN 1043
Query: 1071 LEIMSTC-SSKWMSVQ-YFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQ 1128
E C +SK ++ Y ++ + Q L E E + + + + +
Sbjct: 1044 KEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD 1103
Query: 1129 GTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEEL---QTLCKT 1185
T Q + +AE EN ++++LI N D + +T+ +
Sbjct: 1104 KTNQ---------------IDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVIS 1148
Query: 1186 PPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQES-KERAAEMVKAEV 1244
PP C S EL + I A++K K + + +QE+ R A + KA+
Sbjct: 1149 PP-----------CTGSSEHWKPELE-EKILALEKEKEQLQKKLQEALTSRKAILKKAQE 1196
Query: 1245 LRERQETARKMRKYYLICLQQILQDDGKE 1273
K +K LQ+ + KE
Sbjct: 1197 KERHLREELKQQKDDYNRLQEQFDEQSKE 1225
Score = 99.0 bits (245), Expect = 3e-20
Identities = 212/1051 (20%), Positives = 450/1051 (42%), Gaps = 168/1051 (15%)
Query: 198 YQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQL----- 252
++ +A NN S + S+ + L Q + + Q+ QL++ ERQ
Sbjct: 728 FKKNADNNSSAFTAL--SEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYE 785
Query: 253 -----ENLI-EKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEA 306
+NL+ E+++ + + + ++ ++++E D + L E L ++ + + E+
Sbjct: 786 SQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKES 845
Query: 307 QIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHS-ESLQRAREQHESIVMG 365
++ +++ + E++ + E+ + + Q L++ E+LQ+ E+ + V
Sbjct: 846 EVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTE 905
Query: 366 LTKKYEEQVLSLQK---NLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINK 422
++ E+++ L + +L + LKEQ ++ SR ++ K+ + + ++
Sbjct: 906 ISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE 965
Query: 423 LTRSLEESQKQCAH---LLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKD 479
++ + + S+++ H LL+ + Q +LQ L ++ + L+EEL LKD
Sbjct: 966 MSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR----LEEELANLKD 1021
Query: 480 EISLYESAAKLGIHPSDSEGELNIELTE-SYVDLGIKKVNWKKSKVTSIVQEEDP--NEE 536
E S+ E+ + TE V+ + + + VTS QE + +
Sbjct: 1022 E----------------SKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT 1065
Query: 537 LSKDEFILK-LKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLH-QVKKDEKSIE-- 592
+S+ E L+ ++ +++ L + + LV Q+ L+D +I+ L ++ +++ I+
Sbjct: 1066 ISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL 1125
Query: 593 VETKTDTSEKPKNQLWPESST------------SDVVRDDILLLKNEIQVLQQQNQELKE 640
+ + TD S+ L E+ + + IL L+ E + LQ++ QE
Sbjct: 1126 ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
Query: 641 TEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALE 700
+ + Q+ +R+ + ++ D R +Q E K E
Sbjct: 1186 SRKAILKKAQEKERHLRE-------ELKQQKDDYNRLQEQFDEQSK-------------E 1225
Query: 701 KQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEK 760
+ + + + +Q+R +D K + Q+ E C LE L K TE + TQ
Sbjct: 1226 NENIGDQLRQLQIQVRESID--GKLPSTDQQ---ESCSSTPGLEEPLFKATE-QHHTQPV 1279
Query: 761 IKEKLIQQLEKEWQSKLDQ--------TIKAMKKKTLDCGSQTDQV------TTSDVISK 806
++ L +W S + ++ +K + + ++ ++ TTS++ K
Sbjct: 1280 LESNLCP----DWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 807 KEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIA-VQNAHQR 865
E ++EQ +Q LE E ++K + E E+ H E++ +++E + +Q A
Sbjct: 1336 SEEVFQLQEQ--INKQGLEIE-------SLKTVSHEAEV-HAESLQQKLESSQLQIAGLE 1385
Query: 866 WLGEL-PELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPG 924
L EL P+L E Q L+ KK E+ +S+ + EK ++ L ++ I+
Sbjct: 1386 HLRELQPKLDELQKLIS---KKEED---------VSYLSGQLSEK-EAALTKIQTEIIEQ 1432
Query: 925 KELEEKIHSLQKELELKNEEVPVV-IRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFL 983
++L + +H+ Q E++ K + + ++ EL + K+K EEI +Q R
Sbjct: 1433 EDLIKALHT-QLEMQAKEHDERIKQLQVELCEM-----KQKPEEIGEESRAKQQIQR--- 1483
Query: 984 DDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYE 1043
K+ L + KE + K+ LQ+E L + E + ++ ++
Sbjct: 1484 -----KLQAALISRKEALKENKS---LQEELSLA----RGTIERLTKSLADVESQVSAQN 1531
Query: 1044 EDILTVLGVL-LSDTQKEHISDSEDKQLLE---IMSTCSSKWMSVQYFEKLKGCIQKAFQ 1099
++ TVLG L L +++ + D+ LLE + S+C S ++++ + K + K +
Sbjct: 1532 KEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1591
Query: 1100 DTLPLLVENADPEWKKRNMAELSKDS----------ASQGTGQGDPGPAAGHHAQPL--A 1147
+ + EW++++ EL K+ +++ A Q L
Sbjct: 1592 SLKSSKIAEST-EWQEKHK-ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGK 1649
Query: 1148 LQATEAEAEENNKVVEELIEENNDMKNKLEE 1178
L++TEA +E K ++E +E +MK K+ +
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRK 1680
Score = 96.3 bits (238), Expect = 2e-19
Identities = 175/846 (20%), Positives = 371/846 (43%), Gaps = 106/846 (12%)
Query: 198 YQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIE 257
++S AQ Q++ DT +G ++ L Q+ + + L + + +L L
Sbjct: 2264 WESKAQTEVQLQQKVC--DTLQGENKELLS---------QLEETRHLYHSSQNELAKLES 2312
Query: 258 KLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKA---LETQ 314
+L + Q+ L++ L K++K L +R+ + QN K QLE ++A L ++
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372
Query: 315 I-QALKVNEEQMIK----KSRTTEMALESLKQQ----------LVDLHHSESLQRAREQH 359
+ + + + E+++I K ++A+ L+QQ L+ E++ E
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENK 2432
Query: 360 ESI-----VMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKL 414
+++ +M K +++ + + LD+ V ++ ++ R+ +QLE +I L
Sbjct: 2433 KAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIIL 2492
Query: 415 EKTEIINKL----TRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKAL 470
EK ++I + + EE + +H+ S E A+L +L Q ++ + +
Sbjct: 2493 EKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS--ENAKLDAELIQYREDLNQVITIKDSQ 2550
Query: 471 QEELTE--LKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKK------- 521
Q++L E L+ L AKL +SE E N +L S+ L +K + K
Sbjct: 2551 QKQLLEVQLQQNKELENKYAKLEEKLKESE-EANEDLRRSFNALQEEKQDLSKEIESLKV 2609
Query: 522 --SKVTSIVQEEDPNEELSKDEFILKLK-AEVQRLLGSNSMKRHLVSQLQNDL----KDC 574
S++T V L LK+K EV RL S + +++L+ +L K+
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669
Query: 575 HKKIEDLH-QVKKDEKSIE-----VETKTDTSEKPKNQLWPESSTSDVV--RDDILLLKN 626
KK+ ++ ++KK+ K + + +T+T+E+ +L D+V +L++
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAEL-----ARDLVEMEQKLLMVTK 2724
Query: 627 EIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMK 686
E + L Q Q + L+N+ ++ ++ + +D +E Q + +
Sbjct: 2725 ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELA-------QLKEQGLL 2777
Query: 687 TQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELT 746
+ R++LL++ A + T S L+KLN+++ + E L + + ++
Sbjct: 2778 NRERDALLSETAF-------SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED-SYN 2829
Query: 747 LRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISK 806
++ K + + ++ L +LEK +S+ + A + T Q+ + S + +
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889
Query: 807 KEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRW 866
++ +++E K QQ L+ ++I +K +L+ ++ TK +I + Q
Sbjct: 2890 RDR--LLKELKNLQQQYLQINQEITELHPLK-----AQLQEYQDKTKAFQIMQEELRQEN 2942
Query: 867 LGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKE 926
L EL + ++ E+ W E HE + ++ A+S+ K++ S L+N+ + +
Sbjct: 2943 LSWQHELHQ----LRMEKSSW-EIHERRMKEQYLMAISD-KDQQLSHLQNLIRELRSSSS 2996
Query: 927 LEEKIH-SLQKELELKNEEVP-----VVIRAELAKAR-SEWNKEKQEEIHRIQEQNEQDY 979
+ + Q++ + P +V EL + + ++ KE ++ RIQ+ N ++
Sbjct: 2997 QTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLN-SNF 3055
Query: 980 RQFLDD 985
Q L++
Sbjct: 3056 SQLLEE 3061
Score = 65.1 bits (157), Expect = 5e-10
Identities = 240/1294 (18%), Positives = 517/1294 (39%), Gaps = 201/1294 (15%)
Query: 226 LGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTL 285
L ++++ +NM+ L++ + + N ++ + + ++ Y +V +KD
Sbjct: 16 LSGDDDTDQNMRAPLDPELHQESDMEFNNTTQE--DVQERLAYAEQLVVELKD------- 66
Query: 286 SLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD 345
+R+ Q +++ L+ + KA + +I+ LK++ + K + +E +K Q
Sbjct: 67 IIRQKDVQLQ---QKDEALQEERKAADNKIKKLKLHAKA---KLTSLNKYIEEMKAQ--- 117
Query: 346 LHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQL 405
++ Q E + K E+ + ++K L+E+E++ S L+ + Q
Sbjct: 118 ---GGTVLPTEPQSEEQLSKHDKSSTEEEMEIEK----IKHKLQEKEELISTLQAQLTQA 170
Query: 406 ERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSAN 465
+ Q A + E + + L+E + + ++ LQ QL Q Q A
Sbjct: 171 QAEQPAQSSTEMEEFVMMKQQLQEKE------------EFISTLQAQLSQTQAEQA---- 214
Query: 466 MNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNW-KKSKV 524
+ ++E+ + ++ L+E + +D E E+ +L L + + +++V
Sbjct: 215 AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 525 TSIVQE-----EDPNEELSKDEFILKLKAEVQRLLGSNSMKRH----LVSQLQNDLKD-- 573
++Q+ E N+ LS+ + +++AE L + +R L+ +++ ++ +
Sbjct: 275 VDLLQQELTAAEQRNQILSQQ--LQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 574 --CHKKIEDLHQV-----KKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKN 626
H E++H + + + E+E++ E+ K++ E TS IL L+
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ-KHKAEMEEKTS-----HILSLQK 386
Query: 627 EIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCER-----TYQQH 681
Q LQ LK+ KL + Q Q +Q + Q+ + QQH
Sbjct: 387 TGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQH 446
Query: 682 HEAMKTQ-----------IRESLLAKHALEKQQLFEAYERTHL--------QLRSELDKL 722
A +T + E +A +L+K+ + E+ L +L++E +KL
Sbjct: 447 ETASQTSFPDVYNEGTQAVTEENIA--SLQKRVVELENEKGALLLSSIELEELKAENEKL 504
Query: 723 NKEVTAV--QECYLEVCREKDNLELT--LRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLD 778
+ ++T + Q E RE + + K + +++ + + E Q KE L
Sbjct: 505 SSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLL 564
Query: 779 QTIKAMKK---KTLDCGSQTDQVTTSDVISKKEMAIM----------------------- 812
+ +A ++ L + + +V+ +KEM M
Sbjct: 565 EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPL 624
Query: 813 ----------IEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNA 862
+E+++ + + ++I++ A +ELK + + AV +
Sbjct: 625 MPNEESSLPAVEKEQASTEHQSRTSEEISLNDA------GVELKSTKQDGDKSLSAVPDI 678
Query: 863 HQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS--FAVSEAKEKWKSELENMRKN 920
Q EL L ++ K +E +E +++++ +++ E++K +N
Sbjct: 679 GQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738
Query: 921 ILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNK----EKQ--------EEI 968
E +++ S KEL + E V + E+ A +E + E Q E+I
Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798
Query: 969 HRIQ-EQNEQDYRQFLDDHRNKINEVLAAAKED--FMKQKTELLLQKETELQTCLDQSRR 1025
H + E +D + ++ +N++++V E ++ L KE+E+ ++ R
Sbjct: 799 HSLSIEAKSKDVK--IEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRH 856
Query: 1026 EWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQK----EHISDSEDKQLLEIMSTCSSKW 1081
+ + + + Q E +I + +LL + + + +D+Q+ EI + + K
Sbjct: 857 --ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 1082 MSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGH 1141
+ + + G K ++ L LL + E KK + E ++ S+ + PA
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLL--SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQI 972
Query: 1142 HAQPL--ALQATEAEAEENNKVVE-------ELIEENNDMKNKLEELQTLCK--TPPRSL 1190
+ L + E E+ + ++ EL++ + ++ +L L+ K P
Sbjct: 973 SKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET 1032
Query: 1191 SAGAIE---------NACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVK 1241
G +E C+ +E Q I + K+++ +R E K A E +
Sbjct: 1033 ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTI-SEKEVELQHIRKDLEEKLAAEEQFQ 1091
Query: 1242 AEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMN--AASKLATMAKLLETPISS 1299
A V + Q K + I L Q + + +K I + AS ++A + ET + S
Sbjct: 1092 ALVKQMNQTLQDKTNQ---IDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVIS 1148
Query: 1300 KSQSKTTQSALPLTSEMLIAVKKSKRNDVNQKIPCCIESKS---NSVNTITRTLCEQAPK 1356
+ +++ P E ++A++K K + +K+ + S+ R L E+ +
Sbjct: 1149 PPCTGSSEHWKPELEEKILALEKEK-EQLQKKLQEALTSRKAILKKAQEKERHLREELKQ 1207
Query: 1357 RRAACNLQRLLENSEHQS--IKHVGSKETHLEFQ 1388
++ N RL E + QS +++G + L+ Q
Sbjct: 1208 QKDDYN--RLQEQFDEQSKENENIGDQLRQLQIQ 1239
Score = 48.9 bits (115), Expect = 4e-05
Identities = 97/498 (19%), Positives = 200/498 (40%), Gaps = 86/498 (17%)
Query: 240 QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRE--------SQ 291
+L + K +++ + +KL ++++++L+H I+++E + + E Q
Sbjct: 2661 ELVCVQKEAAKKVGEIEDKL---KKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
Query: 292 KLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSES 351
KL KE + L AQI++ + +L+ + + ++ + ++ ++L L
Sbjct: 2718 KLLMVTKENK-GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGL 2776
Query: 352 LQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQE-DICSRLKDHVKQLERNQE 410
L R R+ S EE LS + L+ + + EQ + S+L+D Q++ +
Sbjct: 2777 LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSK 2836
Query: 411 A---IKLEKTEIINKLTRSLE-ESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANM 466
A ++ E+ + N+L + + E KQ + S S EV L+ + Q
Sbjct: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKE 2896
Query: 467 NKALQE----------ELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKK 516
K LQ+ EL LK ++ Y+ K + + N+ L ++K
Sbjct: 2897 LKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEK 2956
Query: 517 VNW----KKSKVTSIVQEEDPNEELSKDEFILK-----------LKAEVQRLL------- 554
+W ++ K ++ D +++LS + +++ LK + QR
Sbjct: 2957 SSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016
Query: 555 --GSNSMKRH---LVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKT------DTSEKP 603
GS ++ L +QL + LK+ H+K + Q+ + + E T DTS+
Sbjct: 3017 PDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSL 3076
Query: 604 KNQLWPESSTSDVVRDDILLLKNEIQVLQ----------------------QQNQELKET 641
+ + D++ + +L+ ++Q LQ +EL+E
Sbjct: 3077 REN---QQHYGDLL-NHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREP 3132
Query: 642 EGKLRNTNQDLCNQMRQM 659
+ Q LCN +++
Sbjct: 3133 QQSFSEAQQQLCNTRQEV 3150
Score = 32.7 bits (73), Expect = 3.0
Identities = 29/161 (18%), Positives = 69/161 (42%), Gaps = 10/161 (6%)
Query: 251 QLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKA 310
QL + ++++++ E +I+ LN + +EK+ L++ L ++ + + ++ L
Sbjct: 3033 QLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAV 3092
Query: 311 LETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTK-- 368
LE Q+Q L+ + Q+ +H + RE +S +
Sbjct: 3093 LEKQVQELQAGPLNI--------DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLC 3144
Query: 369 KYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQ 409
++V L+K L+ E+ S ++ +++LE ++
Sbjct: 3145 NTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 119 bits (297), Expect = 3e-26
Identities = 208/997 (20%), Positives = 427/997 (42%), Gaps = 134/997 (13%)
Query: 280 KDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESL 339
K+ + +RE Q +N L++Q+ A + Q+Q E ++ ++ L +
Sbjct: 850 KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 340 KQQLVDLHHS------------ESLQRAREQHESIVMGLTKKYEEQVLSLQK-NLDATVT 386
KQ+L ++ H + LQ +++ + + L ++ EE+ + QK L+ T
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 387 --ALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQ 444
LK+ E+ L+D +L + ++ ++ E LT EE K A L
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE-EEKSKSLAKLKNKHEAM 1028
Query: 445 EVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEIS-LYESAAKLGIHPSDSEGEL-- 501
+ L+ +L++ +K + L+ + T+L D+I+ L A+L + + E EL
Sbjct: 1029 -ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087
Query: 502 ---NIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD----------EFILKLKA 548
+E + ++ +KK+ +S+++ + QE+ +E S++ E + LK
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISEL-QEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 549 EVQRLLGSNSMKRHLVSQLQNDLKDCHKKIED---LHQVK----KDEKSIEVETKTDTSE 601
E++ L S + ++ L S+ + ++ K +E+ H+ + + + S VE + E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 602 KPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDL------CNQ 655
+ K + ++ L NE++VL Q + + K+ Q+L +
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 656 MRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRE-SLLAKHALEKQQLFEAYERTHLQ 714
+R + D Q +D Q ++ S L + Q+L + R L
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 715 LRSELDKLNKEVTAVQECYLEVCREKDNLE----------LTLRKTTEKE---QQTQEKI 761
L ++L ++ E + +E E K NLE ++K E +T E++
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 762 KEKLIQQLE---KEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKC 818
K KL + LE + + K+ K K KT D + D+ +++ A +E+++
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV--DLDHQRQSACNLEKKQK 1444
Query: 819 TIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPEL----- 873
Q L +EK I+ K A ++ E E + E + A++ A ++ EL L
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ-KAELERLNKQFR 1503
Query: 874 AEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHS 933
E + L+ ++ + HE+ +KR A+ + E+ K++LE ELE+++ +
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKR---ALEQQVEEMKTQLE----------ELEDELQA 1550
Query: 934 LQK---ELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKI 990
+ LE+ + + +L + R E ++EK++++ R + E + L+D R +
Sbjct: 1551 TEDAKLRLEVNLQAMKAQFERDL-QGRDEQSEEKKKQLVRQVREMEAE----LEDERKQR 1605
Query: 991 NEVLAAAKEDFM-------------KQKTELLLQ---KETELQTC---LDQSR--REWTM 1029
+ +AA K+ M K + E + Q + +++ C LD +R RE +
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 1030 QEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKW-MSVQYFE 1088
+AK + ++ E +++ + L + + + + E +L + ++ S K ++++
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 1089 KLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLAL 1148
+L+ I + L E + E + EL D + Q D L L
Sbjct: 1726 RLEARIAQ--------LEEELEEE---QGNTELINDRLKKANLQID------QINTDLNL 1768
Query: 1149 QATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKT 1185
+ + A+ EN + ++L +N ++K KL+E++ K+
Sbjct: 1769 ERSHAQKNENAR--QQLERQNKELKVKLQEMEGTVKS 1803
Score = 105 bits (261), Expect = 5e-22
Identities = 189/998 (18%), Positives = 426/998 (42%), Gaps = 120/998 (12%)
Query: 241 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER 300
L L E + +L E+L E+Q + L ++ + L+ + E Q K +
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ 1077
Query: 301 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 360
+ E +++A +++ + +KK R E + L++ L SE R + + +
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL----ESERASRNKAEKQ 1133
Query: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHV----KQLERNQEAIKLEK 416
+G E++ +L+ L+ T+ + Q+++ S+ + V K LE + + +
Sbjct: 1134 KRDLG------EELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 417 TEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTE 476
E+ K ++++EE +Q + + E A+ + ++ + A+ + + E
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR 1247
Query: 477 LKDEISLYESAAKLGIHPSDSEGE-LNIELTESYVDLGIKKVNWKKSKVTSIVQEED-PN 534
K E L E K +EGE + EL + L ++ N VT ++ + D +
Sbjct: 1248 KKVEAQLQELQVKF------NEGERVRTELADKVTKLQVELDN-----VTGLLSQSDSKS 1296
Query: 535 EELSKDEFILKLK-AEVQRLLGSNSMKRHLVS----QLQNDLKDCHKKIEDLHQVKKD-E 588
+L+KD L+ + + Q LL + ++ +S Q++++ +++E+ + K + E
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 589 KSIEV--ETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLR 646
K I D +K ++ + + +V R L+ +++ L Q+++E KL
Sbjct: 1357 KQIATLHAQVADMKKKMEDSVGCLETAEEVKRK----LQKDLEGLSQRHEEKVAAYDKLE 1412
Query: 647 NTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQL-F 705
T L ++ ++ D DH +Q A C +Q +++ AK+A E+ +
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSA---CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 706 EAYER------------THLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEK 753
EA E+ ++ ++EL++LNK+ E ++ KD++ ++ + +
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNKQFRTEME---DLMSSKDDVGKSVHELEKS 1526
Query: 754 EQQTQEKIKE--KLIQQLEKEWQS------KLDQTIKAMKKK-TLDCGSQTDQVTTSDVI 804
++ +++++E +++LE E Q+ +L+ ++AMK + D + +Q
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE---- 1582
Query: 805 SKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQ 864
KK++ + E + ++ +Q + +A+ A KKLE++L K +E + +A++
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQ-RSMAV-AARKKLEMDL---------KDLEAHIDSANK 1631
Query: 865 RWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPG 924
+ +L + QA +K ++ ++ +++AKE K +L++M ++
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREE-----ILAQAKENEK-KLKSMEAEMIQL 1685
Query: 925 KELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLD 984
+E +++ + + +E+ I K ++++ E Q + E + Q
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ--- 1742
Query: 985 DHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEE 1044
+ IN+ L A + T+L L++ + +++ R+ ++ K +++++ + E
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQK---NENARQQLERQNKELKVKLQEMEG 1799
Query: 1045 DILT--VLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTL 1102
+ + + + + + + D + E + C K +K +D L
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDNETKERQAAC-----------KQVRRTEKKLKDVL 1848
Query: 1103 PLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQAT------EAEAE 1156
L V++ +R AE KD A + + + A+ A +A + E E
Sbjct: 1849 -LQVDD------ERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Query: 1157 ENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGA 1194
+ + + + E + +KNKL P R GA
Sbjct: 1902 DATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGA 1939
Score = 98.6 bits (244), Expect = 4e-20
Identities = 199/1017 (19%), Positives = 414/1017 (40%), Gaps = 138/1017 (13%)
Query: 299 EREIQLEAQIKALETQIQA-LKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRARE 357
+R+ QL A +K L+ A LK+ Q + + L+ +Q+ + E L + RE
Sbjct: 801 KRQQQLTA-MKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVRE 859
Query: 358 QHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKT 417
+ + LT ++ +LQ L A L+EQ + L ++L A K E
Sbjct: 860 KQLAAENRLT-----EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE 914
Query: 418 EIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTEL 477
EI + L +EE +++C HL QA+K K +Q+ + EL
Sbjct: 915 EICHDLEARVEEEEERCQHL-----------------QAEK---------KKMQQNIQEL 948
Query: 478 KDEISLYESA-AKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSK----------VTS 526
++++ ESA KL + +E +L +L E + L + K K T+
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLK-KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 527 IVQEEDPNEELSK-----DEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDL 581
+ +EE+ ++ L+K + I L+ ++R +L+ D D +I +L
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 582 HQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKET 641
Q + E +++ K + + ++ E++ ++ I L+++I LQ+ + + +
Sbjct: 1068 -QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS 1126
Query: 642 EGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEK 701
K +DL ++ + K E D + T Q K + ++L K E+
Sbjct: 1127 RNKAEKQKRDLGEELEAL-------KTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 702 QQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKI 761
+ EA Q++ K ++ V + E + R K NL EK +QT E
Sbjct: 1180 AKTHEA------QIQEMRQKHSQAVEELAEQLEQTKRVKANL--------EKAKQTLENE 1225
Query: 762 KEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQ 821
+ +L +++ Q K D K+K ++ Q QV ++ + + + ++ +Q
Sbjct: 1226 RGELANEVKVLLQGKGD---SEHKRKKVEAQLQELQVKFNE---GERVRTELADKVTKLQ 1279
Query: 822 QNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVK 881
L+ + + K ++ + E+ + + +Q +++ L +L + +
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN 1339
Query: 882 AEQKKWEEQHEVSVNKRISFAVSEAK-EKWKSELENMRKNILPGKELEEKIHSLQKELE- 939
+ +++ EE+ E N A A+ K ++E+ + +E++ K LQK+LE
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK---LQKDLEG 1396
Query: 940 -LKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAK 998
+ E V +L K ++ +E + + + Q + L+ + K +++LA K
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN--LEKKQKKFDQLLAEEK 1454
Query: 999 EDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQ 1058
K E D++ E +E K + L E + +
Sbjct: 1455 TISAKYAEE------------RDRAEAEAREKETKALSLARALEE--------AMEQKAE 1494
Query: 1059 KEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNM 1118
E ++ ++ ++MS+ SV EK K +++ ++ + +E + E +
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE-MKTQLEELEDELQATED 1553
Query: 1119 AELSKD---SASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNK 1175
A+L + A + + D LQ + ++EE K +L+ + +M+ +
Sbjct: 1554 AKLRLEVNLQAMKAQFERD-------------LQGRDEQSEEKKK---QLVRQVREMEAE 1597
Query: 1176 LEELQTLCKTPPRSLSAGA-----IENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQ 1230
LE+ + RS++ A ++ L + + R + IK ++K++ M ++
Sbjct: 1598 LED-----ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 1231 ESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMNAASKLA 1287
E + A + E+L + +E +K++ +Q + E A+++ +LA
Sbjct: 1653 ELDDTRAS--REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 118 bits (296), Expect = 4e-26
Identities = 209/1027 (20%), Positives = 430/1027 (41%), Gaps = 196/1027 (19%)
Query: 219 EGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKD 278
E L+ + G N+ ++ +V + ++ Q E I +LNE+ +
Sbjct: 402 EKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE--ISELNET-----------FLSDS 448
Query: 279 EKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALES 338
EK+ LTL E Q L + + + + + I E+ + +++ + ++ + + ES
Sbjct: 449 EKEKLTLMF-EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFES 507
Query: 339 LKQQLV-DLHHSESLQRAREQHESIVMGLTKKYE---EQVLSLQK---NLDATVTALKEQ 391
+KQQ D+H + R + ++ + + E++LS Q+ L+ T+ L+E+
Sbjct: 508 MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEK 567
Query: 392 EDI----CSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQ---KQCAH----LLQS 440
+ S+ +K+LE ++ EK + INKL S EE K+C +L+
Sbjct: 568 NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILEL 627
Query: 441 GSVQEVAQLQFQLQQAQKAHAMSANMNKALQEE----------------LTELKDEIS-- 482
G E +Q+ + QK + ++ + + L+E+ L+E K+ +S
Sbjct: 628 GKKVEQT-IQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAE 686
Query: 483 ---LYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSK 539
LYE KL +L + L++ + + + + K+ +V+E+D +L +
Sbjct: 687 VKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE 746
Query: 540 DEFILKLKAEVQ-----RLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVK------KDE 588
+E + KL + Q + +GS + + N L+ + + +++ K +DE
Sbjct: 747 NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDE 806
Query: 589 KSIEVETKTDT--------SEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKE 640
K +E+E + E+ K+ L ++R ++ +++E + LQ E+K
Sbjct: 807 KVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN 866
Query: 641 TEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQI----------- 689
K R NQ+L Q+ ++ Q K E + E+ + + HE +K +
Sbjct: 867 ANEKTRLENQNLLIQVEEVSQTCS--KSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAE 924
Query: 690 ----RESL-----------------------LAKHALEKQQLFEAYERTHLQLRSELDKL 722
++SL L K EK++ + ++ + ELD
Sbjct: 925 LILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSS 984
Query: 723 NKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKI--KEKLIQQLEKE------WQ 774
KE V+E + EKD L ++R + + + + EK +QL+ E ++
Sbjct: 985 RKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFE 1044
Query: 775 SKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKE-----------MAIMIEEQKCTIQQN 823
+++ + ++ TL C +T D++++ E + ++ K + +
Sbjct: 1045 HRIEDLTRQLRNSTLQC--ETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE 1102
Query: 824 LEQE---KDIAIK------GAMKKLEIEL--ELKHCENITKQVEIAVQNAHQRWLGELPE 872
LE E K+ IK +++L+++L E K + +++E+ ++A Q L + E
Sbjct: 1103 LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM-E 1161
Query: 873 LAEYQALVK----------------AEQKKWEEQHEVSVNKRISFAVS------EAKEKW 910
+A+Y+ L+K ++ K ++Q + ++ + I+ S E K
Sbjct: 1162 IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI 1221
Query: 911 KSELENMRKNILPGKELEEK----IHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQE 966
K L +K + K+ E SL+ ELE ++V V + +LA+ SE +K
Sbjct: 1222 KQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVE-VYKIQLAEITSEKHK---- 1276
Query: 967 EIHRIQEQNEQDYRQFLDDHRNKI---NEVLAAAK-------EDFMKQKTELLLQKETEL 1016
IH + + + +++ L ++ ++ E AAK +F K + + +
Sbjct: 1277 -IHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335
Query: 1017 QTCLDQSRREWTMQEAKRIQLEIYQYE---EDILTVLGVLLSD---TQKEH--ISDSEDK 1068
+ Q+ E QE + +++ I Q + +D L + +S+ Q EH + + +K
Sbjct: 1336 NKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK 1395
Query: 1069 QLLEIMS 1075
L E +S
Sbjct: 1396 MLQETVS 1402
Score = 110 bits (275), Expect = 1e-23
Identities = 239/1127 (21%), Positives = 477/1127 (42%), Gaps = 170/1127 (15%)
Query: 246 KAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGK---EREI 302
KA +L+ L+ + E+E+Q L + + +K E + + ++ K + +EI
Sbjct: 72 KALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEI 131
Query: 303 Q-LEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSE-SLQRAREQHE 360
+ L+ ++ A+ ++ K N ++ ++++ T++ L +QL ++SE ++++ +E+ E
Sbjct: 132 ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQL---ELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 420
I G +EEQ+L LQK LDAT KE V QL+ EA + I
Sbjct: 189 KIRPG----FEEQILYLQKQLDATTDEKKET----------VTQLQNIIEANSQHYQKNI 234
Query: 421 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELT----- 475
N L L + L++ +EV +L Q++ + K H N L+E L
Sbjct: 235 NSLQEELLQ--------LKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEA 286
Query: 476 -----ELKDEISLYESAAKLGIHPSDSEGELNIELTE-SYVDLGIKKVNWKKSKVTSIVQ 529
+ K E L E+ K + + +I L E ++V+ + VN K + ++
Sbjct: 287 SEKNIQKKYECEL-ENLRKATSNANQDNQICSILLQENTFVE---QVVNEKVKHLEDTLK 342
Query: 530 EEDPNEELSKDEFI----LKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVK 585
E + + KDE LKLK E+ +H+ + ++ +D KI +L K
Sbjct: 343 ELESQHSILKDEVTYMNNLKLKLEMD--------AQHIKDEFFHEREDLEFKINELLLAK 394
Query: 586 KDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKL 645
+++ + + K++ + K + + E+Q L++Q+Q+ ++
Sbjct: 395 EEQGCVIEKLKSELAGLNKQFCYTVEQHN-----------REVQSLKEQHQK------EI 437
Query: 646 RNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLF 705
N+ + + + Q ++CE Q+ EA+ ESL + + +L
Sbjct: 438 SELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY--ESLREIMEILQTELG 495
Query: 706 EAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKI--KE 763
E+ + + S + +V +Q+ EKD L +T + Q EK+ ++
Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKD----ALLETVNRLQGENEKLLSQQ 551
Query: 764 KLIQQLEKEWQ-------------SKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMA 810
+L+ +LE + S+ D +K ++ K + D S +EM
Sbjct: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD 611
Query: 811 IMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQ------ 864
+KC ++ L E ++ + + ELE K +T +E ++ Q
Sbjct: 612 NF--HKKCEREERLILELGKKVEQTI-QYNSELEQK-VNELTGGLEETLKEKDQNDQKLE 667
Query: 865 RWLGELPELAEYQALVKAEQKK-WEEQHEVSVNKRISFAVSEAKEKWKSELEN--MRKNI 921
+ + ++ L+E + ++ AE K +EE +++S K+ +S E + S+ E+ ++++I
Sbjct: 668 KLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKK---QLSRDLEVFLSQKEDVILKEHI 724
Query: 922 LPGKELEEKIHSLQKELE-----LKNEEV-PVVIRAELAKARSEWNKEKQEEIHRIQEQN 975
+LE+K+ + +E + L+NE+V + ++ +L E E E+ +E++
Sbjct: 725 ---TQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSED---SEEKD 778
Query: 976 EQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQS----------RR 1025
+ Q + + KINE K + Q+ E +L+ E E++ ++S R
Sbjct: 779 VVNVLQAVGESLAKINE----EKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLR 834
Query: 1026 EWTMQEA-KRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLL----EIMSTCSSK 1080
++ ++ R +LE Q E++ L LL + E++ LL E+ TCS
Sbjct: 835 DYEQEKVLLRKELEEIQSEKEALQ--SDLLEMKNANEKTRLENQNLLIQVEEVSQTCSK- 891
Query: 1081 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG 1140
S + EK K C K ++ PLL E + ++ + L A + + DP +
Sbjct: 892 --SEIHNEKEK-CFIKEHENLKPLL-EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVK 947
Query: 1141 HHAQPLALQATEAEAEEN--NKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENA 1198
+ + E + +E NK+ ++ ++ + +E QT+ + E
Sbjct: 948 ELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKE-----------ELE 996
Query: 1199 CLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRER-QETARKMRK 1257
L L I+ + K +L Y ++S++ E +A R ++ R++R
Sbjct: 997 SLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRN 1056
Query: 1258 YYLICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSK 1304
L C + + D ++ ++ L + AKLLE I ++K
Sbjct: 1057 STLQC--ETINSDNED-----LLARIETLQSNAKLLEVQILEVQRAK 1096
Score = 37.7 bits (86), Expect = 0.093
Identities = 60/274 (21%), Positives = 108/274 (39%), Gaps = 20/274 (7%)
Query: 154 TNGQKQEFNNQATNV----IKFSDPQWN-HFQGPSCQGLEPYNKVTYKPYQSSAQNNGSP 208
T G KQE + + IK D Q N Q L+ + + + Q S
Sbjct: 1344 TEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSK 1403
Query: 209 AQEITGSDTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNES----ER 264
E+ + + + + Q +VL + Q+ +L E+ ++ ++
Sbjct: 1404 EAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQ 1463
Query: 265 QIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER---EIQLEAQIKALETQIQALKVN 321
Q+ + QL +K+E T S SQ+ +N +ER ++ L + + ++
Sbjct: 1464 QLSKMEAQLFQLKNEPT--TRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETT 1521
Query: 322 EEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGL--TKKYEEQVLSLQK 379
+ + + + T +LE L + L A E +V L T K + + L +
Sbjct: 1522 DTESVSSASTYTQSLEQLLNS-PETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLR 1580
Query: 380 NLDATVTALKEQEDICSRLKDHVKQLERNQEAIK 413
+AT L EQ + LK +++LERNQE K
Sbjct: 1581 ETEATNAILMEQIKL---LKSEIRRLERNQEREK 1611
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 113 bits (282), Expect = 2e-24
Identities = 229/1073 (21%), Positives = 441/1073 (41%), Gaps = 145/1073 (13%)
Query: 224 QFLGANENSAENM--QIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKD 281
Q L E +++ + Q+ QL K KE+QL+ + EK E+ RQ QL +E++
Sbjct: 537 QTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK-QEATRQDHA--QQLATAAEERE 593
Query: 282 GLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALES--L 339
SLRE + + E + A+++ L+ Q+Q NE + ++ T+ E L
Sbjct: 594 A---SLRERDAALKQLEALEKEKAAKLEILQQQLQV--ANEARDSAQTSVTQAQREKAEL 648
Query: 340 KQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLK 399
+++ +L R +EQHE+ + QV L+ L + E+E +
Sbjct: 649 SRKVEELQACVETAR-QEQHEA---------QAQVAELELQLRSEQQKATEKERVAQEKD 698
Query: 400 DHVKQLERNQEAIKLEKTEIINKLTRSLE--ESQKQCAHLLQSGSVQEVAQLQFQLQQAQ 457
+QL+ +E++K+ K + + R+ + E Q++C L++ + V Q + + ++ +
Sbjct: 699 QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE 758
Query: 458 KAHAMSANMNKALQE--ELTELKDEISLYESAAKLGI-HPSDSEGELNIELTESYVDLGI 514
+ A + LQ+ E + + E+ E A + H ++SE E ++ ++ +
Sbjct: 759 EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER-Y 817
Query: 515 KKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDC 574
+ ++++ ++ QE+ + ++ +L+ +++ G S +S+ QN+L +
Sbjct: 818 EDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAEL 877
Query: 575 HKKI-EDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDIL----------- 622
H + L QV+ EK + + D + ++ +++ +V R + L
Sbjct: 878 HANLARALQQVQ--EKEVRAQKLADDLSTLQEKM--AATSKEVARLETLVRKAGEQQETA 933
Query: 623 ---LLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHD---------KQEA 670
L+K + +Q + L+E +G+ + Q M + + ++ + +
Sbjct: 934 SRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG 993
Query: 671 VDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQ 730
+ ER Q+ A TQ R A ALEK A ++L++ L++ E +Q
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKA----ARAELEMRLQNALNEQRVEFATLQ 1049
Query: 731 ECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLD 790
E EK+ + L K E +IKE +++L + + +Q K K+
Sbjct: 1050 EALAHALTEKEGKDQELAKLRGLEAA---QIKE--LEELRQTVKQLKEQLAKKEKEHASG 1104
Query: 791 CGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCEN 850
G+Q++ ++ K A+ E K Q +QE+ LE LE +
Sbjct: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQ-------ADSLERSLEAERASR 1157
Query: 851 ITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKW 910
+ +A + G+L E A Q L ++ Q E++ + S+A+++W
Sbjct: 1158 AERD------SALETLQGQLEEKA--QELGHSQSALASAQRELAAFRTKVQDHSKAEDEW 1209
Query: 911 KSEL-----ENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQ 965
K+++ E RKN L LEE++ L +++ K E + R L A SE +++ +
Sbjct: 1210 KAQVARGRQEAERKNSLISS-LEEEVSILNRQVLEKEGESKELKR--LVMAESEKSQKLE 1266
Query: 966 EEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQK--TELLLQKETELQTCLDQS 1023
E + +Q + + + + + + E + + +E+ KQ+ +E L Q+ T
Sbjct: 1267 ERLRLLQAETASNSARAAE-RSSALREEVQSLREEAEKQRVASENLRQELTS-----QAE 1320
Query: 1024 RREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSE-DKQLLEIMSTCSSKWM 1082
R E QE K Q + +Q E+ LS Q EH S +LL C
Sbjct: 1321 RAEELGQELKAWQEKFFQKEQ--------ALSTLQLEHTSTQALVSELLPAKHLCQQ--- 1369
Query: 1083 SVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHH 1142
L E A E KR+ EL + + G + + A
Sbjct: 1370 ---------------------LQAEQAAAE--KRHREELEQSKQAAGGLRAELLRAQREL 1406
Query: 1143 AQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPC 1202
+ + L+ AE E + + + + L++ L R L A N
Sbjct: 1407 GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA--NLGRQF 1464
Query: 1203 SGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKM 1255
L++ R +Y++ + ++ D AE AEV RE Q TAR++
Sbjct: 1465 LEVELDQAREKYVQELAAVRAD------------AETRLAEVQREAQSTAREL 1505
Score = 109 bits (273), Expect = 2e-23
Identities = 242/1237 (19%), Positives = 498/1237 (40%), Gaps = 167/1237 (13%)
Query: 135 PSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQGPSCQGLEPYNKVT 194
PS C T PE P ++ K+E + S N G P +
Sbjct: 157 PSTCSST----FPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPAS---PMGDIL 209
Query: 195 YKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLEN 254
P + A E + D E AEN +++ + A +Q +
Sbjct: 210 QTPQFQMRRLKKQLADERSNRDELE----------LELAENRKLLTEKDAQIAMMQQRID 259
Query: 255 LIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQ 314
+ LNE + +L ++D+ + LT+ L E+ K Q+ K + Q++ +I L
Sbjct: 260 RLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQL--- 316
Query: 315 IQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQV 374
+EE + E A S QQL D +L E+H T+++ E+
Sbjct: 317 ------SEENGDLSFKLREFA--SHLQQLQD-----ALNELTEEHSK----ATQEWLEKQ 359
Query: 375 LSLQKNLDATV---TALKEQEDI----CSRLKDHVKQLERNQEAIKLEKTEIINKLTRSL 427
L+K L A + L+E+ +I S+L++H+ QL+ N EK E++ + +
Sbjct: 360 AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQ---EKGEVLGDVLQL- 415
Query: 428 EESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESA 487
E+ KQ A L + + Q A+++ + + A +EE +L I+ +S+
Sbjct: 416 -ETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSS 474
Query: 488 AKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELS-----KDEF 542
+ + E E + + + + + + + + + +Q++D +EL+ E
Sbjct: 475 IS-NLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD--QELAGLKQQAKEK 531
Query: 543 ILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEK 602
+L +Q+ ++ RH V QL + LK ++++++ + ++ + + +E+
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
Query: 603 PKNQLWPESSTSDVVRDDILLLKNE----IQVLQQQNQELKETEGKLRNTNQDLCNQMRQ 658
+ L D + L+ E +++LQQQ Q E R++ Q Q ++
Sbjct: 592 REASL----RERDAALKQLEALEKEKAAKLEILQQQLQVANEA----RDSAQTSVTQAQR 643
Query: 659 MVQDFDHDKQEAVDRCERTYQQHHEA------MKTQIRESLLAKHALEKQQLFEAYERTH 712
+ +E E Q+ HEA ++ Q+R + A EK+++ + ++
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSE--QQKATEKERVAQEKDQLQ 701
Query: 713 LQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLE-- 770
QL++ + L +++E E R D LE R +E + +T+ +++ ++ E
Sbjct: 702 EQLQALKESLKVTKGSLEE---EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELE 758
Query: 771 ------KEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNL 824
K +++L Q +A + +T + + + ++ E +++E ++
Sbjct: 759 EERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
Query: 825 EQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQ-------NAHQRWLGELPELAEYQ 877
+ +++ A GAM + ++ + CE ++++ A + ++ + + ELAE
Sbjct: 819 DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH 878
Query: 878 A-LVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQK 936
A L +A Q+ E++ ++++ +S +EK + + + + LE + +
Sbjct: 879 ANLARALQQVQEKEVRA---QKLADDLSTLQEKMAATSKEVAR-------LETLVRKAGE 928
Query: 937 ELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAA 996
+ E + E+ V A + EW +E+Q + Q + + N++ + AA
Sbjct: 929 QQETASREL-VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987
Query: 997 AKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSD 1056
E +Q+ E Q+ + ++ R + + K + E+ ++ L V +
Sbjct: 988 LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047
Query: 1057 TQK--EHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWK 1114
Q+ H ++ + E+ + ++ E+L+ +++
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQL----------------- 1090
Query: 1115 KRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKN 1174
K +A+ K+ AS G G AAG E +E L E + ++
Sbjct: 1091 KEQLAKKEKEHAS---GSGAQSEAAG-------------RTEPTGPKLEALRAEVSKLEQ 1134
Query: 1175 KLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKE 1234
+ ++ Q + RSL A E A ALE L+GQ + +++ +E
Sbjct: 1135 QCQKQQEQADSLERSLEA---ERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
Query: 1235 RAA------------EMVKAEVLRERQETARK------MRKYYLICLQQILQDDGKEGAE 1276
AA + KA+V R RQE RK + + I +Q+L+ +G+
Sbjct: 1192 LAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251
Query: 1277 KKIMNAAS----KLATMAKLLETPISSKSQSKTTQSA 1309
K+++ A S KL +LL+ +S S +S+
Sbjct: 1252 KRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288
Score = 66.6 bits (161), Expect = 2e-10
Identities = 199/1014 (19%), Positives = 393/1014 (38%), Gaps = 138/1014 (13%)
Query: 219 EGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQL---VI 275
+ L++Q +E AE +++ Q + KE + E K E+ Q HQ V+
Sbjct: 727 DALEEQQRCISELKAETRSLVE-QHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVL 785
Query: 276 IKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMA 335
++ + + + Q KE E + + + Q + +EQ++ E A
Sbjct: 786 RRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKA 845
Query: 336 ---LESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQE 392
L+ K+++ + LQ +R+Q+E + L NL + ++E+E
Sbjct: 846 RQELQEAKEKVAGIESHSELQISRQQNE-------------LAELHANLARALQQVQEKE 892
Query: 393 DICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQ 452
+L D + L+ A E + + ++ E+ + L++ + Q ++
Sbjct: 893 VRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL 952
Query: 453 LQQAQKAHAMSANMNKALQEELTELKDEI-----SLYESAAKLGIHPSDSEGE---LNIE 504
+Q + + +A++ E ++ +E+ +L ES + E E L E
Sbjct: 953 EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQE 1012
Query: 505 LTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLV 564
+ DL ++K ++++ +Q NE+ + EF L+ + L K +
Sbjct: 1013 RGRAQADLALEKA--ARAELEMRLQNA-LNEQ--RVEFAT-LQEALAHALTEKEGKDQEL 1066
Query: 565 SQLQNDLKDCHKKIEDLHQVKKD------EKSIEVETKTDTSEKPKNQLWPESSTSDVVR 618
++L+ K++E+L Q K +K E + + + + P + +R
Sbjct: 1067 AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR 1126
Query: 619 DDILLLKNEIQVLQQQNQELK---ETEGKLR----NTNQDLCNQMRQMVQDFDHDKQEAV 671
++ L+ + Q Q+Q L+ E E R + + L Q+ + Q+ H +
Sbjct: 1127 AEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALA 1186
Query: 672 DRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQE 731
Q+ A +T++++ A+ + Q + R E ++ N +++++E
Sbjct: 1187 SA-----QRELAAFRTKVQDHSKAEDEWKAQVA---------RGRQEAERKNSLISSLEE 1232
Query: 732 CYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDC 791
+ + R+ EKE +++E K + E E KL++ ++ ++ +T
Sbjct: 1233 ----------EVSILNRQVLEKEGESKEL---KRLVMAESEKSQKLEERLRLLQAETASN 1279
Query: 792 GSQTDQVTTS---DVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHC 848
++ + +++ +V S +E A E++ +NL QE A + E+ ELK
Sbjct: 1280 SARAAERSSALREEVQSLREEA----EKQRVASENLRQE---LTSQAERAEELGQELKAW 1332
Query: 849 ENITKQVEIAVQNAH------QRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFA 902
+ Q E A+ Q + EL ++AEQ E++H
Sbjct: 1333 QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR---------- 1382
Query: 903 VSEAKEKWKSELENMRKNILPG-KELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWN 961
E E+ K +R +L +EL E I QK E E +RAE A + +
Sbjct: 1383 --EELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAE--QERTAQQLRAEKASYAEQLS 1438
Query: 962 KEKQE-----EIHRIQEQNEQDYRQFL----DDHRNKINEVLAAAKEDFMKQKTELLLQ- 1011
K+ E +R + RQFL D R K + LAA + D + E+ +
Sbjct: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREA 1498
Query: 1012 ----KETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSED 1067
+E E+ T + + ++E +R +Q E LT L Q+E E+
Sbjct: 1499 QSTARELEVMTAKYEGAKVKVLEERQR-----FQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Query: 1068 --KQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDS 1125
K+L + + ++ + G Q+ Q L E +K AE K
Sbjct: 1554 LSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQ 1613
Query: 1126 ASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEEL 1179
+ D A + E +E + +E+L +EN +++ + E L
Sbjct: 1614 MEKAKTHYD------------AKKQQNQELQEQLRSLEQLQKENKELRAEAERL 1655
Score = 43.5 bits (101), Expect = 0.002
Identities = 53/244 (21%), Positives = 108/244 (44%), Gaps = 17/244 (6%)
Query: 199 QSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQ-----IIQLQVLNKAKERQLE 253
Q AQ+ + +T +EG + + L + E Q + QL+V + + +Q+E
Sbjct: 1495 QREAQSTARELEVMTAK--YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVE 1552
Query: 254 NLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALE- 312
L +KL +S++ + +L ++ + S +E+Q+L E + QL + +A E
Sbjct: 1553 ELSKKLADSDQASKVQQQKLKAVQAQGGE---SQQEAQRLQAQLNELQAQLSQKEQAAEH 1609
Query: 313 --TQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKY 370
Q++ K + + ++++ + L SL +QL + + R HE GL K
Sbjct: 1610 YKLQMEKAKTHYDAKKQQNQELQEQLRSL-EQLQKENKELRAEAERLGHELQQAGLKTKE 1668
Query: 371 EEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEES 430
EQ ++L A V +L+ Q + + + + +A+K + + +L S++
Sbjct: 1669 AEQTC---RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSL 1725
Query: 431 QKQC 434
C
Sbjct: 1726 DLSC 1729
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 112 bits (280), Expect = 3e-24
Identities = 221/1043 (21%), Positives = 448/1043 (42%), Gaps = 144/1043 (13%)
Query: 217 TFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVII 276
T LQ+Q + SA + Q + KA LE L LN+S ++ +L QLV +
Sbjct: 1107 TLNELQEQL---KQKSAHVNSLAQDETKLKA---HLEKLEVDLNKSLKENTFLQEQLVEL 1160
Query: 277 K--DEKDG-----LTLSLRESQKLFQNGKEREIQLEAQIKALETQ-IQALKVNEEQMIKK 328
K E+D LT L+ + + FQ+ K E K+LE + ++ K++EE I+
Sbjct: 1161 KMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH---EKSNKSLEDKSLEFKKLSEELAIQL 1217
Query: 329 S---RTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVL---SLQKNLD 382
+ TE LE+ +L+++ S S A S T K +E +L L+
Sbjct: 1218 DICCKKTEALLEAKTNELINI--SSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELE 1275
Query: 383 ATVTALKEQEDICS-RLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSG 441
A + L E+++ + + QLE + IK K +I + +T E QK+ + Q+
Sbjct: 1276 AQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEK-EALQKEGGNQQQAA 1334
Query: 442 SVQEVAQLQFQLQQAQKAHAMS-------------ANMNKALQEELTELKDEISLYESAA 488
S +E Q + + ++ +A++ ++++K L + +L++ ISL E A
Sbjct: 1335 SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEA 1394
Query: 489 KLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKA 548
+ + E EL + DL K K K++++ Q +D + + S+ K KA
Sbjct: 1395 AISSLRKQYDEE-KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE----WKKKA 1449
Query: 549 EVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKK--DEKSIEVETKTDTSEKPKNQ 606
+ + N++K L QL+ K+ ++K E ++ +K+ D+++ + E K++
Sbjct: 1450 QSRFTQHQNTVKE-LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSK 1508
Query: 607 LWP-ESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDH 665
+ ES+ ++ + + Q+ E++ L+N NQ + +++VQ H
Sbjct: 1509 MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQH 1568
Query: 666 ------DKQEAVDRCER---TYQQHHEAMKTQIR------ESLLAKHALEKQQLFEAYER 710
+K V E T + +MK ++ E + ++++L +R
Sbjct: 1569 FQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR 1628
Query: 711 THLQLRSELDKLNKE----VTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLI 766
+ ++L +L ++ + A+++ L EK+ ++ E T+ + +E+ +
Sbjct: 1629 LESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV 1688
Query: 767 QQLEKEWQS----KLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQ 822
LE++ +S + + I K + ++ ++ + + K EE+ +Q+
Sbjct: 1689 HILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT-----YEEKISVLQR 1743
Query: 823 NLEQEKDIAIKGAMKKLE-----IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQ 877
NL +++ + + +K E E+ ++ E + K +E A H E Q
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK-LEHAEAKQH-----------EDQ 1791
Query: 878 ALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKE 937
+++ Q++ EE+ NK+ S V++ EK E + NI + LE +QK
Sbjct: 1792 SMIGHLQEELEEK-----NKKYSLIVAQHVEK-----EGGKNNIQAKQNLENVFDDVQKT 1841
Query: 938 LELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLD-----DHRNKINE 992
L+ K E+ I + K +Q+E+HR++ + + L D RNK E
Sbjct: 1842 LQEK--ELTCQILEQKIKELDSC-LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898
Query: 993 VLAAAKEDFMKQKTELLLQK---ETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTV 1049
+L E+ K K+ L+ K E Q + + +E +++ EI + ++D+ +
Sbjct: 1899 LLEENTEE--KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML 1956
Query: 1050 LGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENA 1109
+KEH +Q LEI+ +Y ++ + I++ +D +E
Sbjct: 1957 --------RKEH------QQELEILKK--------EYDQEREEKIKQEQED-----LELK 1989
Query: 1110 DPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEEN 1169
K+ M E + A + + AQ + + E+ EE N++++++ E++
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD 2049
Query: 1170 NDMKNKLEELQTLCKTPPRSLSA 1192
+D+K + + + ++A
Sbjct: 2050 DDLKRTAKRYEEILDAREEEMTA 2072
Score = 108 bits (269), Expect = 6e-23
Identities = 257/1260 (20%), Positives = 501/1260 (39%), Gaps = 205/1260 (16%)
Query: 253 ENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKA-L 311
E LI++L ER + + + L ++ Q + +++ ++ A+++ L
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREEL 196
Query: 312 ETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYE 371
+ QA K +E+ + +LE Q + L SL + R ++ + + + K
Sbjct: 197 QMDQQAKKHLQEEF-------DASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLP 249
Query: 372 E-----QVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRS 426
+ +V + ++N ++ + E VK LE Q+ +K ++ ++ + +
Sbjct: 250 QLEPQAEVFTKEENPESDGEPVVEDGT-------SVKTLETLQQRVKRQEN-LLKRCKET 301
Query: 427 LEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYES 486
++ ++QC LL S QL +LQ+ +K + L +L + K+ I E
Sbjct: 302 IQSHKEQCT-LLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQ 360
Query: 487 AAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIV-QEEDPNEELSKDEFILK 545
+ I + + +E+ E +++ +S++ + Q E+ E+ K E
Sbjct: 361 DKGMVIAETKRQMHETLEMKE-------EEIAQLRSRIKQMTTQGEELREQKEKSE---- 409
Query: 546 LKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKN 605
R +L+ L +K E+ + K E +++T TSE+ +
Sbjct: 410 ---------------RAAFEELEKALSTA-QKTEEARRKLKAEMDEQIKTIEKTSEEERI 453
Query: 606 QLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDH 665
L E S D++ +E Q+ + Q KE L Q+L +++ ++F
Sbjct: 454 SLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKE----LARKEQELTKKLQTREREFQE 509
Query: 666 DKQEAVDRCERTY----QQHHEAMKTQIRESLLAKHAL---------EKQQLFEAYERTH 712
+ A+++ + Y Q+ + + E L K A+ + QQ E Y
Sbjct: 510 QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRI 569
Query: 713 LQLRSELDKL---NKEVTAVQECYLEVCREKDNLELTL----RKT-------------TE 752
L+L S L+K NK + +LE + K N E+T+ KT TE
Sbjct: 570 LELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE 629
Query: 753 K----EQQTQ---EKIKEKLIQQLE---KEWQSKLDQTIKAMKKKTLD--CGSQTDQVTT 800
K +QQ Q EK++EK Q+ E K+ + I+ M +KTL+ QT+ +
Sbjct: 630 KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL 689
Query: 801 SDVIS-----------------------KKEMAIMIEEQKCTIQQNLE---QEKDIAIKG 834
S +S K+E+ ++EQK QQ ++ +E +++I+
Sbjct: 690 SSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQR 749
Query: 835 AMKKL-----EIELELKHCENITKQVEIAVQNAH---QRWLGELPELA-------EYQAL 879
K L ++EL LK + K+ + V+N +R GEL + + YQ+
Sbjct: 750 TEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSA 809
Query: 880 VKAEQKKWEEQHEVSVNKRISFAVSE-AKEKWKSELENMRKNILPGKELEE-KIHSLQKE 937
+ K +EEQ K + K +E+E +K++ + + ++ L ++
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ 869
Query: 938 LELKNEEVPVVIRA--ELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLA 995
LE +N E+ +++ ++ +++ E ++QE+ +I + E Q + + +I E+L
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI-EILT 928
Query: 996 ---AAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGV 1052
+AKED + +L +E E + + + E Q+AK +Q + + D L
Sbjct: 929 QKLSAKEDSIH-----ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Query: 1053 LLSDT-----QKEHISDSEDKQLLEIMSTCSSKWMS------VQYFEKLKGCIQKAFQDT 1101
L +T QKE +++ ++ + S S +S + E L ++ D
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV 1043
Query: 1102 LPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKV 1161
+ + W+K+ + + + Q + L E EE NK
Sbjct: 1044 ISI--------WEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFG--CEKEEMNKE 1093
Query: 1162 VEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKI 1221
+ L EE L ELQ K +++ A + L ++K+
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAH--------------LEKL 1139
Query: 1222 KCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMN 1281
+ D+ + ++E+ ++V+ ++L E E RK+ + L L+ +E K +
Sbjct: 1140 EVDLNKSLKENTFLQEQLVELKMLAE--EDKRKVSE-----LTSKLKTTDEEFQSLKSSH 1192
Query: 1282 AASKLATMAKLLETPISSKSQS-------KTTQSALPLTSEMLIAVKKSKRNDVNQKIPC 1334
S + K LE S+ + K T++ L + LI + SK N + +I
Sbjct: 1193 EKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISH 1252
Query: 1335 CIESKSNSVNTI---TRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETHLEFQFGD 1391
C + + T T+ E + R Q L S Q+ + KE ++ D
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312
Score = 106 bits (265), Expect = 2e-22
Identities = 240/1228 (19%), Positives = 508/1228 (41%), Gaps = 167/1228 (13%)
Query: 229 NENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSL- 287
NE + E + + K+ +LE+L +L+E + L +L ++KD+ D + L
Sbjct: 672 NEKTLEKLDV---------KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE 722
Query: 288 --------RESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESL 339
Q++ KE E+ ++ KAL+ QI L++ ++ K + + +E+L
Sbjct: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782
Query: 340 KQQLVDLHHSE-SLQRAR------EQHESIVMGLTKKYEEQVLSLQKNL----------- 381
+ D+ SE LQ+A + ++S TK YEEQ+ LQ+ L
Sbjct: 783 E---ADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLT 839
Query: 382 DATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSG 441
+++D+C+ L H Q++ + ++ + +E+ K+ +SL + + L+ G
Sbjct: 840 KQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV-KSLTQVYES---KLEDG 895
Query: 442 SVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGEL 501
+ ++ Q +++ M M + ++E+ L ++S E + IH + E E
Sbjct: 896 NKEQEQTKQILVEKEN----MILQMREGQKKEIEILTQKLSAKEDS----IHILNEEYET 947
Query: 502 NIELTESYVDLGIKKVNWKKS--KVTSIVQEEDPNEELSKDEFILKLK-----AEVQRLL 554
+ E ++ +K + K + QE +EL L K A++ +
Sbjct: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 555 GSNSMK-RHLVSQLQNDLKDCHKKIEDLHQVKKD------EKSIEVETKTDTSEKPKNQL 607
+NS VS+L+ + K+ + + ++H+ + + EK + + + + E + QL
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE-ELQEIHEIQL 1066
Query: 608 WPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDK 667
+ ++ ILL E + + ++ LKE K T +L Q++Q +
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126
Query: 668 QEAVDRCERTYQQHHEAMKTQIRESL-----LAKHALEKQQLFEAYERTHLQLRSELDKL 722
Q+ E + H E ++ + +SL L + +E + L E +R +L S+L
Sbjct: 1127 QD-----ETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTT 1181
Query: 723 NKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIK 782
++E +++ + EK N K+ E + +K+ E+L QL+
Sbjct: 1182 DEEFQSLKSSH-----EKSN------KSLEDKSLEFKKLSEELAIQLD-----------I 1219
Query: 783 AMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIE 842
KK ++T+++ ++ S K AI+ C Q + K+ + E+E
Sbjct: 1220 CCKKTEALLEAKTNELI--NISSSKTNAILSRISHC--QHRTTKVKEALLIKTCTVSELE 1275
Query: 843 LELKHCENITKQVEIAVQNAHQRWLGELPEL----AEYQALV---KAEQKKWEEQHEVSV 895
+L+ + I+ Q A + + ++ A+ ++LV +A QK+ Q + +
Sbjct: 1276 AQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAAS 1335
Query: 896 NKRISFAVSEAKEKWKSELENMRKNILPGKELEEK---IHSLQKEL-----ELKNEEVPV 947
K +++ K K EN+ L +EL+EK I SL K+L +L+N
Sbjct: 1336 EK--ESCITQLK---KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLS 1390
Query: 948 VIRAELAKARSEWNKEKQEEIHRIQE---------QNEQDYRQFLDDHRNKINEVLAAAK 998
A ++ R ++++EK E + ++Q+ + + + +DD NK +E A+
Sbjct: 1391 EKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 999 EDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQ 1058
F + + + KE ++Q L ++ ++ E+ Q + + G + D
Sbjct: 1451 SRFTQHQNTV---KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS 1507
Query: 1059 KEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNM 1118
K + ++ L + + +++ M ++ K ++ + L + D E K+ +
Sbjct: 1508 K---MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE--L 1562
Query: 1119 AELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEE 1178
+ + G + + A L Q +AE K +EL N +K+K EE
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK-KKELEHVNLSVKSKEEE 1621
Query: 1179 LQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAE 1238
L+ A+E+ S L EL+ + + + IK +L ++E +E+ +
Sbjct: 1622 LK-------------ALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKK 1668
Query: 1239 MVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPIS 1298
++ + + + R+ ++ L++ L+ +E I+ ++K
Sbjct: 1669 GTESHLSELNTKLQEREREVHI--LEEKLKSVESSQSETLIVPRSAK--------NVAAY 1718
Query: 1299 SKSQSKTTQSALPLTSEMLIAVKKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRR 1358
++ + +Q + T E I+V + + + + + K +V++ C+ +
Sbjct: 1719 TEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY---QE 1775
Query: 1359 AACNLQRLLENSEHQSIKHVGSKETHLE 1386
L+ E +H+ +G + LE
Sbjct: 1776 RLIKLEH-AEAKQHEDQSMIGHLQEELE 1802
Score = 105 bits (262), Expect = 4e-22
Identities = 223/1140 (19%), Positives = 483/1140 (42%), Gaps = 166/1140 (14%)
Query: 237 QIIQLQVLNKAKERQL-------ENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRE 289
QI QL++L K +++ L ENL + SE +++ + +L + + + + E
Sbjct: 757 QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQS----ATHE 812
Query: 290 SQKLFQNGKEREIQLEAQIKALETQ--IQALKVNEEQMIKKSRTTEMALESLKQQLVDLH 347
K ++ E+ QL+ ++ LET+ + +V E + KK TE L++ K Q+ DL
Sbjct: 813 QTKAYE---EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE--LDAHKIQVQDL- 866
Query: 348 HSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQ--- 404
+ L++ + E V LT+ YE ++ K + T L E+E++ ++++ K+
Sbjct: 867 -MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIE 925
Query: 405 -----LERNQEAIKLEKTEIINKLTRS------LEESQKQCAHLLQSGSVQEVAQLQFQL 453
L +++I + E K +++ K+ L+ + + A+L+ +L
Sbjct: 926 ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 454 QQ-----AQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTES 508
+ +QK +A M + Q + D +S E+ K I +S E++
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI---ESLTEVHRRELND 1042
Query: 509 YVDLGIKKVNWKKSKVTSI--VQEEDPNEELS--KDEFIL------KLKAEVQRLLGSNS 558
+ + KK+N + ++ I +Q ++ +E++ K + +L ++ E+ L
Sbjct: 1043 VISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV 1102
Query: 559 MKRHLVSQLQNDLKDCHKKIEDLHQ----VKKDEKSIEVETKTDTSEKP--KNQLWPESS 612
+ +++LQ LK + L Q +K + +EV+ E + QL
Sbjct: 1103 KQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKM 1162
Query: 613 TSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVD 672
++ + + L ++++ ++ Q LK + K + +D + +++ ++
Sbjct: 1163 LAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK 1222
Query: 673 RCERTYQ---------------------QHHEAMKTQIRESLLAKHA----LEKQ--QLF 705
+ E + H + T+++E+LL K LE Q QL
Sbjct: 1223 KTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT 1282
Query: 706 EAYERTHL---QLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIK 762
E ++ Q +L++ ++ +++ + EK+ L+K +QQ + K
Sbjct: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE----ALQKEGGNQQQAASE-K 1337
Query: 763 EKLIQQLEKEWQSKLDQTI---KAMKKKTLDCGSQTDQVTTSDV-------ISKKEMAI- 811
E I QL+KE ++ + +K+K ++ S + Q+T +V +S+KE AI
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS 1397
Query: 812 ----MIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWL 867
+E+KC + L+Q +D++ K E L+ ++ + + + A R+
Sbjct: 1398 SLRKQYDEEKCEL---LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT 1454
Query: 868 GELPELAEYQALVKAEQKK-WEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKE 926
+ E Q ++ + K+ +E+ ++++ K + + +N R + L G+
Sbjct: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKE------------ELDQQNKRFDCLKGEM 1502
Query: 927 LEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNE--QDYRQFLD 984
++K +KE L+ E ++++ A+ + Q+ I I+ NE ++Y Q D
Sbjct: 1503 EDDKSKMEKKESNLETE-----LKSQTARIMELEDHITQKTIE-IESLNEVLKNYNQQKD 1556
Query: 985 -DHRNKINEV-----LAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLE 1038
+H+ + ++ L K++ +K+ E +L E ++ + ++ E +E + + L
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSM--KAELETKKKELEHVNLS 1614
Query: 1039 IYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAF 1098
+ EE++ + L S++ + +E K+ E K + Q EK + +K
Sbjct: 1615 VKSKEEELKALEDRLESESAAKL---AELKRKAEQKIAAIKKQLLSQMEEKEEQ-YKKGT 1670
Query: 1099 QDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEEN 1158
+ L L N + ++R + L + S + Q + A+ +A + EA+
Sbjct: 1671 ESHLSEL--NTKLQEREREVHILEEKLKSVESSQSET-LIVPRSAKNVAAYTEQEEADSQ 1727
Query: 1159 NKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAV 1218
V + E+ + ++ L E + L + + + E+R QY + +
Sbjct: 1728 GCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF----------EMRCQYQERL 1777
Query: 1219 KKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKK 1278
K++ E+K+ + + + E +E K +KY LI Q + ++ GK + K
Sbjct: 1778 IKLEH------AEAKQHEDQSMIGHLQEELEE---KNKKYSLIVAQHVEKEGGKNNIQAK 1828
Score = 102 bits (255), Expect = 2e-21
Identities = 185/896 (20%), Positives = 383/896 (42%), Gaps = 109/896 (12%)
Query: 237 QIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQN 296
Q+ QL + +L E E QI+ + + + EK+ L +E Q
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQ---KEGGNQQQA 1333
Query: 297 GKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAR 356
E+E + K L I A+ + +E++ +K ++ + SL +QL DL+ +
Sbjct: 1334 ASEKESCITQLKKELSENINAVTLMKEELKEK----KVEISSLSKQLTDLNVQLQNSISL 1389
Query: 357 EQHESIVMGLTKKYEE-------QVLSLQKNLDAT----VTALKEQEDICSRLKDHVKQL 405
+ E+ + L K+Y+E QV L +D ++AL++ +D ++ + K+
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 406 E----RNQEAIK-------------LEKTEIINKLTRSLEESQKQCAHLL------QSGS 442
+ ++Q +K EK E IN L L++ K+ L +S
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 443 VQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELN 502
++ + L+ +L+ +Q A M L++ +T+ EI K D E +
Sbjct: 1510 EKKESNLETELK-SQTARIME------LEDHITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562
Query: 503 IELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRH 562
++ + + +LG +K N K I+ E N+ S + K E++ + S K
Sbjct: 1563 VQKLQHFQELGEEKDNRVKEAEEKILTLE--NQVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 563 LVSQLQNDLK-DCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDI 621
+ L++ L+ + K+ +L + K ++K ++ + + + K + + + + S + +
Sbjct: 1621 ELKALEDRLESESAAKLAELKR-KAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT 1679
Query: 622 LLLKNE--IQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQ 679
L + E + +L+++ + ++ ++ + + N Q+ + D Q V ++TY+
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQE-EADSQGCV---QKTYE 1735
Query: 680 QHHEAMKTQI--RESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVC 737
+ ++ + +E LL + EK++ ++ Q + L KL E +
Sbjct: 1736 EKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIG 1795
Query: 738 REKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQ 797
++ LE +K + Q EK K Q ++ ++ D K +++K L C
Sbjct: 1796 HLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTC------ 1849
Query: 798 VTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEI 857
++ +K + E C ++Q ++ + ++ K E L+ + K E+
Sbjct: 1850 ----QILEQK----IKELDSCLVRQ--KEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 858 AVQNAHQRWLGELPE---LAEYQA--------LVKAEQKKWEEQHEVSVNKRISFAVSEA 906
+N ++ L + L+ +A L AE++K + E+ R+ +
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIV---RLQKDLRML 1956
Query: 907 KEKWKSELENMRKNILPGKELEEKIHSLQKELELK-NEEVPVVIR---AELAKARSEWNK 962
+++ + ELE ++K +E EEKI Q++LELK N + ++R +LA+ E
Sbjct: 1957 RKEHQQELEILKKEY--DQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014
Query: 963 EKQEEIHRIQEQNEQDYRQFLDDHRNKINEVL--AAAKEDFMK---QKTELLLQKETELQ 1017
+E I++ QE + L+ H+ + N++L A K+D +K ++ E +L E
Sbjct: 2015 TIKETINKAQEVE----AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEM 2070
Query: 1018 TCLDQSRREWTMQEAKRIQLEIYQYE---EDILTVLGVLLSDTQKEH-ISDSEDKQ 1069
T + + + K+ Q ++ Q E D +T++ + QK ISDS+ K+
Sbjct: 2071 TAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126
Score = 56.6 bits (135), Expect = 2e-07
Identities = 113/526 (21%), Positives = 223/526 (42%), Gaps = 81/526 (15%)
Query: 698 ALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQT 757
+L K+QL + R L S K ++ VTA Y + REK L+ L ++ +K +
Sbjct: 133 SLNKEQLIQRLRRMERSLSSYRGKYSELVTA----YQMLQREKKKLQGILSQSQDKSLRR 188
Query: 758 QEKIKEKL--IQQLEKEWQSKLD-------------QTIKAMKKKTLDCGSQTDQVTTSD 802
+++E+L QQ +K Q + D QT ++ K+ L G V
Sbjct: 189 IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVL--- 245
Query: 803 VISKKEMAIMIEEQKCTIQQNLEQEKDIAIKG--AMKKLE-IELELKHCENITKQVEIAV 859
K + + + T ++N E + + ++ ++K LE ++ +K EN+ K+ + +
Sbjct: 246 ---KPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETI 302
Query: 860 QN-------------AHQRWLGE-LPELAEYQALVKAEQKKWEEQHEVSVN------KRI 899
Q+ A Q L E L EL + + L AE+ K Q + N +
Sbjct: 303 QSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
Query: 900 SFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSE 959
++E K + LE + I + +++ + +EL + E+ EL KA S
Sbjct: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALST 422
Query: 960 WNKEKQEEIHRIQEQNEQ--DYRQFLDDHRNKINEVLAAAKE---DFMKQKTELLLQKET 1014
K ++ E +EQ + ++ R + + L+ K+ D MK+ +E ++
Sbjct: 423 AQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSE---EQIA 479
Query: 1015 ELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIM 1074
+LQ ++ + K++Q +++E + V L +Q E++ S++K+ E
Sbjct: 480 KLQKLHEKELARKEQELTKKLQTREREFQEQ----MKVALEKSQSEYLKISQEKEQQES- 534
Query: 1075 STCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGD 1134
++++ E K I ++ L L + A+ + E S + + Q
Sbjct: 535 -------LALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN---- 583
Query: 1135 PGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQ 1180
+ ++ LA+ EAE ++NK + ++E++ K +LE L+
Sbjct: 584 -----KNQSKDLAVH-LEAEKNKHNKEITVMVEKH---KTELESLK 620
Score = 55.5 bits (132), Expect = 4e-07
Identities = 65/263 (24%), Positives = 115/263 (43%), Gaps = 11/263 (4%)
Query: 234 ENMQIIQ-LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQK 292
E +Q +Q + NK E EN EK Q + L++ D + L + RE QK
Sbjct: 1882 EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQK 1941
Query: 293 LFQNGKEREIQLEAQIKALETQIQALKVN-----EEQMIKKSRTTEMALESLKQQLVDLH 347
L + + L K + +++ LK EE++ ++ E+ S +QL+
Sbjct: 1942 LGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF 2001
Query: 348 HSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLER 407
+++ Q+ +E +I + K E + L+ + + T LK+ + LK K+ E
Sbjct: 2002 NTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 408 NQEAIKLEKTEIINKLTRSLEESQKQCAHLL---QSGSVQEVAQLQFQLQQAQKAHAMSA 464
+A + E T + L LEE QK+ L ++ V ++ Q Q AQK +S
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISD 2121
Query: 465 NMNK--ALQEELTELKDEISLYE 485
+ K +E++ L+D + YE
Sbjct: 2122 SKLKEQEFREQIHNLEDRLKKYE 2144
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 111 bits (278), Expect = 5e-24
Identities = 167/802 (20%), Positives = 346/802 (43%), Gaps = 94/802 (11%)
Query: 216 DTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVI 275
D E L+++ + S EN +++ L N E +E L ++ E R ++ LV
Sbjct: 2154 DKVENLEREL----QMSEENQELVILDAENSKAE--VETLKTQIEEMARSLKVFELDLVT 2207
Query: 276 IKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMA 335
++ EK+ LT ++E Q QL K L + L+ E+ I+ ++ A
Sbjct: 2208 LRSEKENLTKQIQEKQG----------QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTA 2257
Query: 336 LESLKQQLVDLHHS-------ESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDA----- 383
+E L+ QL +L+ + + + +A EQ + + + L+ L+A
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
Query: 384 --TVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSG 441
+ LKE E LK V+ LER E + + + S E + A + G
Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI--EG 2375
Query: 442 SVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGEL 501
Q + L+ + + N + QE ++EL+ S +E+ + + E
Sbjct: 2376 MTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENI----LQEKEQEKVQ 2431
Query: 502 NIELTESYVDLGIKKVNWKKSKVTSIVQEEDP----NEELSKDEFILKLKAEVQRLLGSN 557
E + + +++ ++ +V ++ +++ + LS L+L+ + Q L G +
Sbjct: 2432 MKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELE-KAQLLQGLD 2490
Query: 558 SMKRHLVSQLQNDLKDCHKKIEDLHQV--KKDEKSIEVETKTDTSE---------KPKNQ 606
K + + LQ+ + +++ED Q KKDE+ ++ + E + ++Q
Sbjct: 2491 EAKNNYIV-LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQ 2549
Query: 607 LWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHD 666
LW E + +R+ + L+ +IQVLQ +N L++T L+++ ++L N++ D
Sbjct: 2550 LWKEQNLE--LRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM----D 2603
Query: 667 KQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEV 726
K V++ + + E + + K A +++L R +L+ L+++
Sbjct: 2604 KMSFVEKVNKMTAKETELQREM--HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
Query: 727 TAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKK 786
++E LE K +L+ + EKE + +E+I E+Q +L + K +
Sbjct: 2662 DQLKELTLENSELKKSLDCMHKDQVEKEGKVREEI---------AEYQLRLHEAEKKHQA 2712
Query: 787 KTLDCGSQ--TDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELE 844
LD Q + T + ++ KE + ++ + + ++ ++E + ++K + LE EL+
Sbjct: 2713 LLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE-ELK 2771
Query: 845 LKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVS 904
+N+ ++ +N +R G++ + L+K+ K+ EE+ E+ + +
Sbjct: 2772 KTKMDNLKYVNQLKKEN--ERAQGKM------KLLIKS-CKQLEEEKEILQKELSQLQAA 2822
Query: 905 EAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEK 964
+ K+K + ++ EL +I L++ LE K +E + + S EK
Sbjct: 2823 QEKQKTGTVMDT------KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEK 2876
Query: 965 QEEI------HRIQEQNEQDYR 980
+E+ H +Q++QD R
Sbjct: 2877 AKEMLETQVAHLCSQQSKQDSR 2898
Score = 101 bits (252), Expect = 5e-21
Identities = 235/1173 (20%), Positives = 470/1173 (40%), Gaps = 167/1173 (14%)
Query: 242 QVLNKAKERQLENLIEKLNESERQIRYLNHQLVI-------IKDEKDGLTLSLRESQKLF 294
Q L K +E +E L +KL+++E++ + L L + +K+EK + E++KL
Sbjct: 571 QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630
Query: 295 QNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHH-SESLQ 353
+ + L+++I LET ++ ++ + ++ RT EM E+L ++ +LH+ +S
Sbjct: 631 TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690
Query: 354 RAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIK 413
E + M L +K E S QK+ KE E++C + Q+E + ++
Sbjct: 691 VEVETQKLAYMELQQKAE---FSDQKH-------QKEIENMCLKTSQLTGQVEDLEHKLQ 740
Query: 414 LEKTEIINK--LTRSLEESQKQCAHLLQSGSVQEVAQLQFQ-----LQQAQKAHAMSANM 466
L EI++K + L + LL+S V Q Q H AN+
Sbjct: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800
Query: 467 ---NKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSK 523
++ E +E + E + + + DS E ++E ++ ++ ++K + +
Sbjct: 801 IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL-EFSLE-SQKQMNSDLQKQCEELVQ 858
Query: 524 VTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLH- 582
+ ++E E F+ + + +L S +++V++ + L++ K+++ L+
Sbjct: 859 IKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLND 918
Query: 583 QVKKDEKSI-EVETKTDTSEKPKNQLWPESSTSDVVRDD----ILLLKNEIQVLQQQNQE 637
+V+ ++ I E++ E +L S T + + + I L K EI+ L Q+N
Sbjct: 919 KVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGT 978
Query: 638 LKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKH 697
LKE L +L + D ++++++ Y+Q E L+
Sbjct: 979 LKEINASLNQEKMNLIQKSESFANYID-EREKSISELSDQYKQ----------EKLILLQ 1027
Query: 698 ALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQT 757
E + AYE + ++ +K +K + EC +C + N L++ KE Q
Sbjct: 1028 RCE--ETGNAYEDLSQKYKAAQEKNSKLECLLNEC-TSLCENRKNELEQLKEAFAKEHQE 1084
Query: 758 -------QEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTT---------- 800
E+ + L+ +LE Q+ + + G ++ T
Sbjct: 1085 FLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK 1144
Query: 801 --SDVISKKE--MAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVE 856
+D++ + E M +M + +C QNLE E I+ ++K E E E C N Q++
Sbjct: 1145 EVNDLLQENEQLMKVMKTKHEC---QNLESE---PIRNSVK--ERESERNQC-NFKPQMD 1195
Query: 857 IAVQ----NAHQRWLGELPELAEYQALVKAEQKKWEE--QHEVSVNKRISFAVSEAKEKW 910
+ V+ +++ L +L + + L E +K +E QHE+ R S ++
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQ-TIRGDLETSNLQDMQ 1254
Query: 911 KSELENMRKNILPGKE------------LEEKIH---SLQKELELKN--EEVPVVIRAEL 953
E+ ++ + +E + H SLQ + N E++ +++AE
Sbjct: 1255 SQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEK 1314
Query: 954 AKARSEWNKEKQEEIHRIQEQNEQ-----DYRQFLDDHRNKINEVLA--AAKEDFMKQKT 1006
+ +E N + E I ++ E+ + + L+D ++ L +F +Q
Sbjct: 1315 YELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN 1374
Query: 1007 ELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSE 1066
E Q L + + E K +Q+ + +E L++ SE
Sbjct: 1375 E---QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSL--------------QSE 1417
Query: 1067 DKQLLEIMSTCSSKWMSVQ-YFEKLKG---CIQKAFQDTLPLLVENADPEWKKRNMAELS 1122
K L + SSK +Q Y + LK + ++ LV+ ++ + LS
Sbjct: 1418 HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLS 1477
Query: 1123 KDSASQGTGQGDPGPAAGHHA------QPLALQATEAEAEENNKVVEE-----LIEENND 1171
+ G ++ + A L E N V+E L EEN
Sbjct: 1478 SSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLT 1537
Query: 1172 MKNK-------LEELQTLCKTPPRSL--------SAGAIENACLPCSGGALEELRGQYIK 1216
K +EEL++LC+ +SL S G ++N ++EL
Sbjct: 1538 RKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNK-------EIQELEQLLSS 1590
Query: 1217 AVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQI--LQDDGKEG 1274
+++ C +Y+ E+++ ++ + E + A K + L ++ LQ G +
Sbjct: 1591 ERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDL 1650
Query: 1275 AEKKIMNAASKLATMAKLLETPISSKSQSKTTQ 1307
+ + ++ ++ A + IS + S+TT+
Sbjct: 1651 SSRSLLGIDTEDAIQGRNESCDISKEHTSETTE 1683
Score = 100 bits (250), Expect = 9e-21
Identities = 258/1288 (20%), Positives = 532/1288 (41%), Gaps = 240/1288 (18%)
Query: 184 CQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQI----- 238
C G + + P + Q + E++ S + FLG N+ N+Q+
Sbjct: 1721 CSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLG-NQEDIHNLQLRVKET 1779
Query: 239 ----IQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVI-----IKDEKDGLTLSLRE 289
++L + + ++R++E+L+ ++ E + ++ QL+ I+ EK L +E
Sbjct: 1780 SNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELK-KE 1838
Query: 290 SQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMA------LESLKQQL 343
+ L + + + ++ +ET + L + E KS ++ +S K++
Sbjct: 1839 NSDLSEKLEYFSCDHQELLQRVETS-EGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF 1897
Query: 344 VDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTAL---------KEQEDI 394
+D+ + L R R + SI E + L L+ +L+ T K++ +
Sbjct: 1898 LDVENE--LSRIRSEKASI--------EHEALYLEADLEVVQTEKLCLEKDNENKQKVIV 1947
Query: 395 CSRLKDHVKQLERNQEAIKLE----KTEIINKL-------TRSLEESQKQCAHLLQSGSV 443
C + V ERNQ +L+ KT +++L T+ LE Q +C H +Q
Sbjct: 1948 CLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ---- 2003
Query: 444 QEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNI 503
VA+ + + ++ + +S+++++ L+++ T L++++ E DS+ +
Sbjct: 2004 --VAEAEVK-EKTELLQTLSSDVSELLKDK-THLQEKLQSLEK---------DSQA---L 2047
Query: 504 ELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHL 563
LT+ ++ I ++N K K + + E LS+ ++ ++L S +++ L
Sbjct: 2048 SLTKCELENQIAQLN--KEKELLVKESESLQARLSESDY--------EKLNVSKALEAAL 2097
Query: 564 VSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPK--NQLWPESSTSDVVRDDI 621
V + + L+ + E++HQ+++ + + V + D ++ +L +D ++D +
Sbjct: 2098 VEKGEFALRLSSTQ-EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2156
Query: 622 LLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQH 681
L+ E+Q + ++NQEL ++ D ++ K E
Sbjct: 2157 ENLERELQ-MSEENQEL--------------------VILDAENSKAEV----------- 2184
Query: 682 HEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKD 741
E +KTQI E + + +E + LRSE + L K++ Q E+ D
Sbjct: 2185 -ETLKTQIEEMARS---------LKVFELDLVTLRSEKENLTKQIQEKQGQLSEL----D 2230
Query: 742 NLELTLRKTTEKEQQTQEKIKEK------LIQQLEKEWQSKL-----DQTIKAMKKKTLD 790
L + + E+++Q + +IKE+ ++Q KE + DQ I +++LD
Sbjct: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2290
Query: 791 CGSQTDQVTTSDVISKKEMAIMIEEQK--CTIQQNLEQEKDI-AIKGAMKKLEIELELKH 847
+ + + I K + +E+K C +QQ E E +KG ++ LE ELE+
Sbjct: 2291 PPIEEEHQLRNS-IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIAR 2349
Query: 848 CENITKQVEIAVQNAHQRWLGELPEL-AEYQALVKAEQKKWEEQHEVSVNKRISFAVSEA 906
T Q A++ + + GE+ L A+ + + ++ + E V++ +E
Sbjct: 2350 ----TNQEHAALEAENSK--GEVETLKAKIEGMTQS--LRGLELDVVTIRSEKENLTNEL 2401
Query: 907 KEKWK--SELENMR---KNILPGKELEE---------KIHSLQKELELKNEEVPVVIRAE 952
+++ + SELE + +NIL KE E+ + LQ +L+ NE V + +
Sbjct: 2402 QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Query: 953 LAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNK-------INEVLAAAKEDFMKQK 1005
A E N Q E +++ Q LD+ +N +N ++ ++ KQK
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQ---LLQGLDEAKNNYIVLQSSVNGLIQEVEDG--KQK 2516
Query: 1006 TELLLQKETELQTCLDQSR-REWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISD 1064
E +K+ E+ +Q + +E + + +++ E ++E L + + + QK +
Sbjct: 2517 LE---KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 1065 SEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKD 1124
S++ L + + S + +++ +L + +F + + + A +R M E+++
Sbjct: 2574 SKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMT--AKETELQREMHEMAQK 2631
Query: 1125 SAS-QGTGQGDPGPAAGH-------------HAQPLALQATEA----------EAEENNK 1160
+A Q G+ AG + L L+ +E + E+ K
Sbjct: 2632 TAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK 2691
Query: 1161 VVEE------------------LIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPC 1202
V EE L++ N + +++ + + LS+ +E L
Sbjct: 2692 VREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS 2751
Query: 1203 SGGALE---ELRGQYIKAVKKIKCDMLRYIQESK---ERAAEMVKAEVLRERQETARKMR 1256
S L + Q ++ +KK K D L+Y+ + K ERA +K + +Q K
Sbjct: 2752 SKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEI 2811
Query: 1257 KYYLICLQQILQDDGKEGA--EKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTS 1314
+ Q Q+ K G + K+ +++ + + LE + +L ++
Sbjct: 2812 LQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH 2871
Query: 1315 EMLIAVKKSKRNDVNQKIPCCIESKSNS 1342
E L K+ V C +SK +S
Sbjct: 2872 EKLEKAKEMLETQVAHL--CSQQSKQDS 2897
Score = 89.4 bits (220), Expect = 3e-17
Identities = 198/1004 (19%), Positives = 412/1004 (41%), Gaps = 140/1004 (13%)
Query: 233 AENMQIIQLQVLNK--AKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRES 290
A+NM + L+K + ++QLEN +E+ + + I ++E +++
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 291 QKLFQNGKEREIQ----LEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDL 346
L ++ E++ + LEA++K ++ + + E+M K+ + E L L++++
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKI--- 544
Query: 347 HHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLE 406
+Q S+ + +K + V L+K D + LK++E +L D + + E
Sbjct: 545 ---------NQQENSLTL---EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTE 592
Query: 407 RNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANM 466
+ +A+ L E+ K L+E +K +S + + + Q++ + + Q
Sbjct: 593 KESKAL-LSALELKKKEYEELKE-EKTLFSCWKSENEKLLTQMESEKENLQ--------- 641
Query: 467 NKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTS 526
+K E +I +E ++ D E L++E+ + L K V + K+
Sbjct: 642 SKINHLETCLKTQQIKSHEYNERVRTLEMDRE-NLSVEIRNLHNVLDSKSVEVETQKLAY 700
Query: 527 I-VQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVK 585
+ +Q++ + + I + + +L G H + L N++ D + +DLH
Sbjct: 701 MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 586 KDEKSI--EVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEG 643
+ + + + T+E + L + ++ + + ++++ E +
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 644 KLRNTNQDLCNQMRQMVQDFDHDKQEAVD---RCERTYQQHHEAMKTQIRESLLAKHALE 700
+N + L N++ + + KQ D +CE Q +K +I E+L+ +
Sbjct: 821 SPKN-SAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ-----IKGEIEENLMKAEQMH 874
Query: 701 KQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEK 760
+ + E +R + KL ++ +A Q E +N E L+ +K + Q +
Sbjct: 875 QSFVAETSQR--------ISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926
Query: 761 IKE-----KLIQQLEKEWQSKLDQTIKAMKKK---TLDCGSQTDQVTTSDVISKKEMAIM 812
I+E L++ KE Q L +T+ KK+ + + + T + + KE+
Sbjct: 927 IQELKKSNHLLEDSLKELQ-LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINAS 985
Query: 813 IEEQKCTIQQNL--------EQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQ 864
+ ++K + Q E+EK I+ K E + L+ CE + A ++ Q
Sbjct: 986 LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCE----ETGNAYEDLSQ 1041
Query: 865 RWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPG 924
++ KA Q+K + E +N+ S E K+ELE +++
Sbjct: 1042 KY--------------KAAQEK-NSKLECLLNECTSLC-----ENRKNELEQLKEAF--A 1079
Query: 925 KELEEKIHSL------QKELELKNEEVPVVIRAELA----KARSEWNKEKQEEIHRIQEQ 974
KE +E + L + L L+ E V +R+E+ ++SE KQE + +EQ
Sbjct: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQ 1139
Query: 975 NEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKR 1034
N+ M+++ LLQ+ +L + +++ E E++
Sbjct: 1140 NK-------------------------MQKEVNDLLQENEQLMKVM-KTKHECQNLESEP 1173
Query: 1035 IQLEIYQYEEDILTVLGVLLSDTQKEHIS-DSEDKQLLEIMSTCSSKWMSVQYFEKLKGC 1093
I+ + + E + D + + IS DS + QL+++ + +K + +Q EK K C
Sbjct: 1174 IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKEC 1233
Query: 1094 IQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQ------PLA 1147
+Q Q L + + + + ++ L KD + GP +Q +
Sbjct: 1234 LQHELQTIRGDLETSNLQDMQSQEISGL-KDCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292
Query: 1148 LQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLS 1191
LQ T + E K+ E L E ++ +L + ++ C T R ++
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMA 1336
Score = 84.0 bits (206), Expect = 1e-15
Identities = 195/978 (19%), Positives = 399/978 (40%), Gaps = 145/978 (14%)
Query: 307 QIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGL 366
+I+ LE Q+ LK ++Q + + E AL+ KQ+ V+ +E RE +M +
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQK-VENEKTEGTNLKRENQR--LMEI 75
Query: 367 TKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRS 426
+ E+ + L + + QE +L KQ+E+ ++ +K K+E L RS
Sbjct: 76 CESLEKTKQKISHELQVKESQVNFQE---GQLNSGKKQIEKLEQELKRCKSE----LERS 128
Query: 427 LEESQKQCAHLLQSGSVQEVAQLQF---QLQQAQKAHAMSANMNKALQEELTELKDEISL 483
+ +Q L + Q++ Q K + NK + EE L+ E+
Sbjct: 129 QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEV-EERKRLEAEVKA 187
Query: 484 YESAAKLGIHPSDSEGELNI--------------ELTESYVDLGIKKVNWKKSKVTSIVQ 529
++ P + +I E T S++ ++ ++ S
Sbjct: 188 LQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFS 247
Query: 530 EEDPNEELSKDEFILKL-KAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLH-QVKKD 587
E +E++ L++ K + NS HL+ QL+ ++ KI +L +++
Sbjct: 248 GE---QEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
Query: 588 EKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQ------QQNQELKET 641
EK E K ++ + QL E + +++ + +L K ++++ Q + +
Sbjct: 305 EK----EMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL 360
Query: 642 EGKLRNTNQDLCNQ----------MRQMVQDFDHDKQEAVDRCERTYQ------------ 679
E KL+ +DL Q + Q +++ + + QE + R +R++Q
Sbjct: 361 EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR 420
Query: 680 ---------QHHEAMKTQIRESLLAKHALEK------------QQLFEAYERTHLQLRSE 718
H ++ ++ + K LE +Q F+A + +LR
Sbjct: 421 LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRS 480
Query: 719 LDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQ---EKIKEKLIQQ--LEKEW 773
++++ KE ++ + RE +LE L+ + Q+Q E++K K Q + ++
Sbjct: 481 MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540
Query: 774 QSKLDQ-----TIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEK 828
Q K++Q T++ +K D Q D + D++ K+E IE+ + + ++ K
Sbjct: 541 QEKINQQENSLTLEKLKLAVADLEKQRD--CSQDLLKKREH--HIEQLNDKLSKTEKESK 596
Query: 829 DIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWE 888
+ +KK E E ELK + + W E +L L + E +K
Sbjct: 597 ALLSALELKKKEYE-ELKEEKTL-----------FSCWKSENEKL-----LTQMESEKEN 639
Query: 889 EQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVV 948
Q +++ + + + K E +R + + L +I +L L+ K+ EV
Sbjct: 640 LQSKIN---HLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQ 696
Query: 949 IRAEL-AKARSEWNKEK-QEEIHRIQEQNEQDYRQFLD-DHRNKI--NEVLAAAK--EDF 1001
A + + ++E++ +K Q+EI + + Q Q D +H+ ++ NE++ + +D
Sbjct: 697 KLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDL 756
Query: 1002 ---MKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQ 1058
+ +LL K+ L T D R + Q ++ +I+ G + S+
Sbjct: 757 HAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQ----QPAMHHSFANIIGEQGSMPSERS 812
Query: 1059 KEHI-SDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRN 1117
+ + +D K + + S S++ +++ +QK ++ + + E + K
Sbjct: 813 ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872
Query: 1118 MAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEE----NNKV------VEELIE 1167
M + SQ + +A + L A E + +E N+KV ++EL +
Sbjct: 873 MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKK 932
Query: 1168 ENNDMKNKLEELQTLCKT 1185
N+ +++ L+ELQ L +T
Sbjct: 933 SNHLLEDSLKELQLLSET 950
Score = 79.0 bits (193), Expect = 4e-14
Identities = 230/1182 (19%), Positives = 463/1182 (39%), Gaps = 170/1182 (14%)
Query: 304 LEAQIKALETQIQAL---KVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE 360
LE + A + + + + EE + +K + A + + + + +SL++ E+ E
Sbjct: 1512 LEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME 1571
Query: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII 420
S G+ K E Q L + + + QE C R K ++ + E+ Q+ + E+
Sbjct: 1572 S--QGIMKNKEIQELE-------QLLSSERQELDCLR-KQYLSENEQWQQKLTSVTLEME 1621
Query: 421 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQ---EELTEL 477
+KL +++++ L EVA+LQ Q + + A+Q E
Sbjct: 1622 SKLAAEKKQTEQLSLEL-------EVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDIS 1674
Query: 478 KDEIS-LYESAAKLGIHP---SDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDP 533
K+ S E K +H D++ +LN+++ + +K + + E P
Sbjct: 1675 KEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPP 1734
Query: 534 NEE-------------------------LSKDEFILKLKAEVQRLLGSNSMKRHL----- 563
E+ L E I L+ V+ N H+
Sbjct: 1735 GEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD 1794
Query: 564 --VSQLQNDLKDCHKKI--EDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRD 619
V L N++K+ K+ +++ + K E IE+E +K + L S +
Sbjct: 1795 RKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDL---SEKLEYFSC 1851
Query: 620 DILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQ 679
D L ++ + N +L+ K ++ +D+ + + ++ + + + R
Sbjct: 1852 DHQELLQRVETSEGLNSDLEMHADK--SSREDIGDNVAKVNDSWKERFLDVENELSRIRS 1909
Query: 680 Q----HHEAMK-------TQIRESLLAKHALEKQQLFEAYERT-------HLQLRSELDK 721
+ HEA+ Q + L K KQ++ E QLR ELD
Sbjct: 1910 EKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDT 1969
Query: 722 LNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEK--LIQQLEKEWQSKL-D 778
++K+ TA+ + ++ + LE + Q + ++KEK L+Q L + L D
Sbjct: 1970 MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD 2029
Query: 779 QTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQ---EKDIAIKGA 835
+T K ++L+ SQ +T KC ++ + Q EK++ +K +
Sbjct: 2030 KTHLQEKLQSLEKDSQALSLT-----------------KCELENQIAQLNKEKELLVKES 2072
Query: 836 MKKLEIELELKHCE--NITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEV 893
+ L+ L E N++K +E A L E E+ + + Q EE H++
Sbjct: 2073 -ESLQARLSESDYEKLNVSKALEAA-----------LVEKGEFALRLSSTQ---EEVHQL 2117
Query: 894 SVN-KRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNE-EVPVVIRA 951
+++ + ++K E +++ L++K+ +L++EL++ E + V++ A
Sbjct: 2118 RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDA 2177
Query: 952 ELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQ 1011
E +KA E K + EE+ R + E D + N ++ K+ + + +LL
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQI--QEKQGQLSELDKLLSS 2235
Query: 1012 KETELQTCLDQSRREWTMQEAKRIQLEIYQYE-EDILTVLGVLLSDTQ----KEHISDSE 1066
++ L+ ++ + E ++E + +E+ Q + +++ + L D + E D
Sbjct: 2236 FKSLLE---EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPP 2292
Query: 1067 DKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQ------DTLPLLVENADPEWK-KRNMA 1119
++ ++ ++ ++ EK + C+ + + D L VEN + E + R
Sbjct: 2293 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352
Query: 1120 ELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEEL 1179
E + A G+ + A +L+ E + E L E + ++ EL
Sbjct: 2353 EHAALEAENSKGEVET-LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL 2411
Query: 1180 QTLCKTPPRSLSAGAIENACL-PCSGGALEELRGQYIKAVKKI--------KCDMLRYIQ 1230
+ + + L E + S A+E L+ Q + +++ C
Sbjct: 2412 EIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL 2471
Query: 1231 ESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQ------DDGKEGAEKKIMNAAS 1284
S+ E+ KA++L+ E K I LQ + +DGK+ EKK S
Sbjct: 2472 SSQVECLELEKAQLLQGLDEA-----KNNYIVLQSSVNGLIQEVEDGKQKLEKK-DEEIS 2525
Query: 1285 KLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSKRNDVNQKIPCCIESKSNSVN 1344
+L + E +S SQ + L E + + ++ ++ QKI ++SK+ S+
Sbjct: 2526 RLKNQIQDQEQLVSKLSQ---VEGEHQLWKEQNLEL-RNLTVELEQKIQ-VLQSKNASLQ 2580
Query: 1345 TITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETHLE 1386
L L ++ + S + + + +KET L+
Sbjct: 2581 DTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQ 2622
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 109 bits (272), Expect = 3e-23
Identities = 216/984 (21%), Positives = 432/984 (43%), Gaps = 147/984 (14%)
Query: 221 LQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNE---SERQIRYLNHQLVI-- 275
LQ+ NE + +N + + + KE+ L EK NE S++ I+ HQ +
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLL---KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 276 --IKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTE 333
++ SL E +L+ ++ +ET+ Q LK +Q+ ++ E
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 334 MALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQED 393
L+ ++ L HS+ L+ R+ E+ G K E++ LS +K +D KEQ+
Sbjct: 407 QHGLQLQSEINQL-HSKLLETERQLGEA--HGRLK--EQRQLSSEKLMD------KEQQV 455
Query: 394 ICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQL 453
+LK + +LE + TE+ ++L ++ ++ Q+Q A LQ + ++ + Q L
Sbjct: 456 ADLQLK--LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA--LQQSTTAKLREAQNDL 511
Query: 454 QQAQKAHAMSANMNKALQEELTELKDEISLYESAAK-LGIHPSDSEGEL---------NI 503
+Q + + L+ L + K+ ISL E + L EGE N
Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH 571
Query: 504 ELTESYVDLGIKKVNWKKS------KVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSN 557
L E L K N +S + VQE+ + ++D +L L+ V L
Sbjct: 572 TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR-VLSLETSVNELNSQL 630
Query: 558 SMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVV 617
+ + VSQL +K + + K +++ +++ DT++
Sbjct: 631 NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA-DLQNHLDTAQN--------------- 674
Query: 618 RDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERT 677
L+++ Q L + +L + KL++ Q+ C+Q+ ++++ K++ + ++T
Sbjct: 675 -----ALQDKQQELNKITTQLDQVTAKLQD-KQEHCSQLESHLKEY---KEKYLSLEQKT 725
Query: 678 YQQHHEAMKTQIRESLLAKHALEK--QQLFEAYE-RTHLQLR-SELDK-LNKEVTAVQEC 732
+ + K + +SL K + E+ Q L + + T L+LR +EL K L E V
Sbjct: 726 EELEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 733 YLEVCREKDNLELTLRKTTEKEQQTQ--EKIKEKLIQQLE---KEWQSKLDQTIKAMKKK 787
L++ ++ + LE +K T++E++ Q ++ E L Q+ + +E +++ T+ ++K
Sbjct: 785 RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV 844
Query: 788 TLDCGS-QTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELK 846
++ + T+ T D +SK + + + E+E KG L++E K
Sbjct: 845 KMEKEALMTELSTVKDKLSK------VSDSLKNSKSEFEKENQ---KGKAAILDLE---K 892
Query: 847 HCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEV-----SVNKRISF 901
C+ + Q+++ ++N L E + L K+ +K+ E H++ S+ +++
Sbjct: 893 TCKELKHQLQVQMENT----------LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
Query: 902 AVSEAKEKWKSELE---NMRKNILPGKELEEKIHSLQKELE---LKNEEVPVVIRAELAK 955
A + K+ K E + N+ + ++ +++I +LQ EL+ L+ E+ ++ +L +
Sbjct: 943 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 956 ARSEW--NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAA-------------AKED 1000
A E KEK + E++++ ++Q D + +E+LA A+ED
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 1001 FMKQKTELLLQKE--TELQTC-----LDQSRREWTMQE----AKRIQLEIYQYEEDILTV 1049
+ + ++ Q + EL+T D +++E +QE + IQ E E++++
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 1050 LGVLLSDTQKEHISDSEDKQLLEIMSTCSS-KWMSVQYFEKLKGCIQKAFQDTLPLLVE- 1107
L + E I ++K++ ++ S K S++ LK Q Q L L +
Sbjct: 1123 KSKL---AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA 1179
Query: 1108 ---NADPEWKKRNMAELSKDSASQ 1128
A E +KRN ++ KD +
Sbjct: 1180 DSLKAAVEQEKRNQ-QILKDQVKK 1202
Score = 99.0 bits (245), Expect = 3e-20
Identities = 239/1171 (20%), Positives = 471/1171 (40%), Gaps = 199/1171 (16%)
Query: 229 NENSAENMQIIQ-LQVLNKAKE--RQLENLIEKLNES----ERQIRYLNHQLVIIKDEKD 281
NE+S+E Q ++ L A E + E + + N+S E + + +++ E
Sbjct: 34 NESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQ 93
Query: 282 GLTLSLRESQKLFQNGKEREI-------QLEAQIKALETQIQALKVNEEQMIKKSRTTEM 334
L SL+E +K + ++E+ Q EA+ L T A + EQ +++++T
Sbjct: 94 DLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENF 152
Query: 335 ALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDI 394
++ +K DL ++ Q A E + + KY+E+ SL++ + VT L E
Sbjct: 153 NIKQMK----DLFEQKAAQLATE-----IADIKSKYDEE-RSLREAAEQKVTRLTE---- 198
Query: 395 CSRLKDHVKQLERNQEAIKLE--KTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQ 452
E N+EA ++ KTE LLQ +++VA L+ +
Sbjct: 199 -----------ELNKEATVIQDLKTE------------------LLQRPGIEDVAVLKKE 229
Query: 453 LQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDL 512
L Q Q + NM + E +LKDE +S + E I S +
Sbjct: 230 LVQVQ---TLMDNMTLERERESEKLKDECKKLQSQY--------ASSEATISQLRSELAK 278
Query: 513 GIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLK 572
G +V VQE + KLK+ V L N + + + D
Sbjct: 279 G-------PQEVAVYVQE------------LQKLKSSVNELTQKNQTLTENLLKKEQD-- 317
Query: 573 DCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQ 632
+ K+E+ H + K ++ + QL S S+ I + E+
Sbjct: 318 --YTKLEEKHNEESVSKK-NIQATLHQKDLDCQQLQSRLSASETSLHRIHV---ELSEKG 371
Query: 633 QQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRES 692
+ Q+LKE ++ Q L + +Q+ Q + +Q + Q H + ++T+
Sbjct: 372 EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE---- 427
Query: 693 LLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTE 752
+QL EA+ R Q + +KL + V + L++ R ++ L+ + +TE
Sbjct: 428 ---------RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
Query: 753 KEQQTQEKIKEKLIQQ-LEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVI---SKKE 808
+ Q + ++ QQ L++ +KL + +++ G + ++ + + SK+
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538
Query: 809 MAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLG 868
++++ +E++ + E + A+ +++ L+ + +T++++ ++ Q
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ-EQVTQLTEKLKNQSESHKQAQEN 597
Query: 869 ELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELE 928
++ E +A ++A Q + E SVN+ ++ ++E+KEK S+L+ K
Sbjct: 598 LHDQVQEQKAHLRAAQDR-VLSLETSVNE-LNSQLNESKEK-VSQLDIQIK--------- 645
Query: 929 EKIHSLQKELELKNEEVPVVIRAELAK---ARSEWNKEKQEEIHRIQEQNEQDYRQFLD- 984
+ EL L E RA+L ++KQ+E+++I Q +Q + D
Sbjct: 646 -----AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK 700
Query: 985 -DHRNKINEVLAAAKEDF--MKQKTELL------------------------LQKETELQ 1017
+H +++ L KE + ++QKTE L LQ++ +L
Sbjct: 701 QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN 760
Query: 1018 TCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTC 1077
T L+ E + Q ++ EI L L +++ E+KQ+L+
Sbjct: 761 TDLELRATELSKQ--LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 1078 SSKWMSVQYFEKLKGCI-------QKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGT 1130
S+ +Q+ E+L I QK + L+ E + + K +++ K+S S+
Sbjct: 819 LSQETKIQH-EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
Query: 1131 GQGDPGPAA----------GHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQ 1180
+ G AA H + ++ T E +E K +E+ E ++ +K +L +Q
Sbjct: 878 KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 1181 TLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMV 1240
+L E L + L++ Q K ++ ++ + L+ K +
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE-LKIAVLQKTELENKL 996
Query: 1241 KAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSK 1300
+ ++ + QE A + K +LQ++ ++ E + ++LL T +
Sbjct: 997 QQQLTQAAQELAAEKEKI------SVLQNNYEKSQETFKQLQSDFYGRESELLAT----R 1046
Query: 1301 SQSKTTQSALPLTSEMLIAVKKSKRNDVNQK 1331
K+ + L L E LI S RN + +
Sbjct: 1047 QDLKSVEEKLSLAQEDLI----SNRNQIGNQ 1073
Score = 96.7 bits (239), Expect = 2e-19
Identities = 186/887 (20%), Positives = 390/887 (43%), Gaps = 90/887 (10%)
Query: 248 KERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQ 307
++RQL + EKL + E+Q+ L +L ++++ + E Q K++ + +A
Sbjct: 439 EQRQLSS--EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496
Query: 308 IKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQ-----------RAR 356
++ +++ + + EQ++++ + +++L+ L + SL +A
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG 556
Query: 357 EQHESIVMGLTKK---YEEQVLSLQKNLDATVTALKE-QEDICSRLKDHVKQLERNQEAI 412
E +++ L +K +EQV L + L + K+ QE++ ++++ L Q+ +
Sbjct: 557 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 413 KLEKTEIINKLTRSLEESQKQCAHL-LQSGSVQEVAQLQFQLQQAQKAHAMS--ANMNKA 469
+T +N+L L ES+++ + L +Q + E+ + AQ+A + A
Sbjct: 617 LSLETS-VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 470 LQEELTEL-KDEISLYESAAKL---GIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVT 525
LQ++ EL K L + AKL H S E L E E Y+ L K
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK-EYKEKYLSLEQK---------- 724
Query: 526 SIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVK 585
+ E ++L D L++KA ++ L +R L + L+ + K++E ++
Sbjct: 725 -TEELEGQIKKLEADS--LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 586 KDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQ-NQELKETEGK 644
+ ++++ K++ E K +L + +++ D L E ++ ++ N ++ T +
Sbjct: 782 SSTR-LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
Query: 645 LRNTNQDLCNQMRQM--VQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQ 702
L+ + M ++ V+D +++ + +++ ++ K I + L K E +
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD--LEKTCKELK 898
Query: 703 QLFEAYERTHLQLRSELDK-LNKEVTAVQECYLEVCREKDNL---ELTLRKTTEKEQQTQ 758
+ L+ + EL K L KE A + LE+ ++ L + TL++ ++EQQ Q
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 759 EKIKE--KLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVT--TSDVISKKEMAIMIE 814
I E + +Q +K+ ++ + A+ +KT Q+T ++ ++KE +++
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 815 EQKCTIQQNLEQEKD---------IAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQR 865
Q+ +Q + +A + +K +E +L L + I+ + +I QN +
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 866 WLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSE-AKEKWK-SELENMR----K 919
L E + K +Q + + + K S E EK K +E+E ++ K
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 920 NILPGKELEEKIHSLQKELELKN----------EEVPVVIRAELAKARSEWNKEKQEEI- 968
I E E K H L+ E+ N +++ + +A+ KA E K Q+ +
Sbjct: 1139 EITKLNE-ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK 1197
Query: 969 HRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTE---LLLQKETELQTCLDQSRR 1025
+++++ E+ ++F++ +E+ KE MK+ E L + T L L ++
Sbjct: 1198 DQVKKEEEELKKEFIEKEAKLHSEI--KEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255
Query: 1026 EWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLE 1072
EW Q ++R E+ + +D+ + VL + Q + E + LLE
Sbjct: 1256 EW--QSSQRRVSELEKQTDDLRGEIAVLEATVQN---NQDERRALLE 1297
Score = 94.7 bits (234), Expect = 6e-19
Identities = 158/767 (20%), Positives = 322/767 (41%), Gaps = 90/767 (11%)
Query: 232 SAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQ 291
+A+ Q LQ + L++ ++LN+ Q+ + +L ++ L L+E +
Sbjct: 656 AAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK 715
Query: 292 KLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIK------------KSRTTEMALESL 339
+ + + +++ +LE QIK LE +K ++EQ ++ + R TE++ +
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLE 775
Query: 340 KQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLK 399
++ + LQ+ E ESI LTK+ EE+ + Q + + E++ +R++
Sbjct: 776 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 400 DHVKQLER---NQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQA 456
V +L++ +EA+ E + + +KL++ + + + + + A L +
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 457 QKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKK 516
+ H + M L+E+ ELK + + A+ +L +EL
Sbjct: 896 ELKHQLQVQMENTLKEQ-KELKKSLEKEKEASH----------QLKLEL----------- 933
Query: 517 VNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDC-- 574
S ++Q ++ ++ K+E +L+ + L S+ K+ + LQ +LK
Sbjct: 934 ----NSMQEQLIQAQNTLKQNEKEE--QQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987
Query: 575 -HKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQ 633
++E+ Q + + + E+ + + +N T ++ D ++E L
Sbjct: 988 QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESE---LLA 1044
Query: 634 QNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESL 693
Q+LK E KL +DL + Q+ + + + + T +Q + Q++E
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGN--QNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 694 LAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEK 753
A ++K++ + E L +E KL E+ + +C E K N EL K
Sbjct: 1103 KALQDIQKEKSLKEKE-----LVNEKSKL-AEIEEI-KCRQEKEITKLNEELKSHKLESI 1155
Query: 754 EQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMI 813
++ T K ++L+ Q + E Q K D A++++ + DQV + KKE
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI--- 1212
Query: 814 EEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCEN---ITKQVEIAVQNAHQRWLGEL 870
EK+ + +K+ E+ ++ KH EN +T Q+ +N LG +
Sbjct: 1213 -------------EKEAKLHSEIKEKEVGMK-KHEENEAKLTMQITALNEN-----LGTV 1253
Query: 871 PELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAK-EKWKSELENMRKNILPGKELEE 929
+ E+Q + Q++ E + + + R AV EA + + E + + L G+ E
Sbjct: 1254 KK--EWQ----SSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIE 1307
Query: 930 KIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNE 976
K+ + EL+ K + ++ + +S K Q + E NE
Sbjct: 1308 KLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNE 1354
Score = 76.3 bits (186), Expect = 2e-13
Identities = 145/693 (20%), Positives = 284/693 (40%), Gaps = 109/693 (15%)
Query: 215 SDTFEGLQQQFLGANENSAENMQIIQ-LQVLNKAKERQLENLIE----KLNESERQIRYL 269
S+ E ++Q+ E Q + L K + +L N I+ +L + + + L
Sbjct: 792 SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851
Query: 270 NHQLVIIKDEKDGLTLSLRESQKLF----QNGKEREIQLEAQIKALETQIQALKVNEEQM 325
+L +KD+ ++ SL+ S+ F Q GK + LE K L+ Q+Q V E
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ---VQMENT 908
Query: 326 IKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATV 385
+K+ + + +LE K + H L+ Q + I T K E+ ++ L +
Sbjct: 909 LKEQKELKKSLEKEK----EASHQLKLELNSMQEQLIQAQNTLKQNEKE---EQQLQGNI 961
Query: 386 TALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQE 445
LK+ + + K ++ L+ + L+KTE+ NKL + L ++ ++ A
Sbjct: 962 NELKQSSE---QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELA---------- 1008
Query: 446 VAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIEL 505
+ +K + N K+ QE +L+ + ES EL
Sbjct: 1009 --------AEKEKISVLQNNYEKS-QETFKQLQSDFYGRES-----------------EL 1042
Query: 506 TESYVDLGIKKVNWKKSKVTSIVQEE---DPNEELSKDEFILKLKAEVQRLLGSNSMKRH 562
+ DL K V K S+ QE+ + N+ ++++ I +LK L ++ K
Sbjct: 1043 LATRQDL--KSVEEK----LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQ 1096
Query: 563 LVSQLQNDLKDCHKK--IEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVR-D 619
+ + L+D K+ +++ V + K E+E EK +L E + +
Sbjct: 1097 QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156
Query: 620 DILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQ 679
+I LK+ Q+L QQ EL Q + ++ V+ ++Q D+ ++
Sbjct: 1157 EITNLKDAKQLLIQQKLEL-----------QGKADSLKAAVEQEKRNQQILKDQVKK--- 1202
Query: 680 QHHEAMKTQI--RESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVC 737
E +K + +E+ L EK+ + +E +L ++ LN+ + V
Sbjct: 1203 -EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV-------- 1253
Query: 738 REKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQ 797
K + + R+ +E E+QT + E I LE Q+ D+ +A+ ++ L + ++
Sbjct: 1254 --KKEWQSSQRRVSELEKQTDDLRGE--IAVLEATVQNNQDER-RALLERCLKGEGEIEK 1308
Query: 798 VTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAM---KKLEIELELKHCENITKQ 854
+ T + E+ ++ +Q+ + + + IK +K + E+++C K
Sbjct: 1309 LQTKVL----ELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKG 1364
Query: 855 VEIAVQNAHQRWLGEL--PELAEYQALVKAEQK 885
+ V+ H R G + E + AL + +K
Sbjct: 1365 FSVTVRRHHCRQCGNIFCAECSAKNALTPSSKK 1397
Score = 74.3 bits (181), Expect = 9e-13
Identities = 165/788 (20%), Positives = 336/788 (42%), Gaps = 106/788 (13%)
Query: 618 RDDILLLKNEIQVLQ-----------------QQNQELKETEGKLRNTNQDLCNQMRQMV 660
RDD+ LL+ E+Q LQ ++ Q L++ E K D +++ +
Sbjct: 82 RDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLE 141
Query: 661 QDFDHDKQE--AVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSE 718
Q + + E + + + ++Q + T+I + + +K+ E++ L EA E+ +L E
Sbjct: 142 QQLEEAQTENFNIKQMKDLFEQKAAQLATEIAD-IKSKYD-EERSLREAAEQKVTRLTEE 199
Query: 719 LDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLD 778
LNKE T +Q+ E+ + ++ + K KE + + + + + E+E KL
Sbjct: 200 ---LNKEATVIQDLKTELLQRPGIEDVAVLK---KELVQVQTLMDNMTLERERE-SEKLK 252
Query: 779 QTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEE-QKCTIQQN-LEQEKDIAIKGAM 836
K ++ + + Q+ + +E+A+ ++E QK N L Q+ + +
Sbjct: 253 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312
Query: 837 KKLE--IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVS 894
KK + +LE KH E + I HQ+ L + + Q+ + A + H V
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQA-TLHQKDL----DCQQLQSRLSASETSLHRIH-VE 366
Query: 895 VNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELA 954
++++ EA +K K EL + + L+ + LQ++ E K E+ + +++E+
Sbjct: 367 LSEK-----GEATQKLKEELSEVETKY---QHLKAEFKQLQQQREEK-EQHGLQLQSEIN 417
Query: 955 KARS---EWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAK-EDFMKQKTELLL 1010
+ S E ++ E R++EQ + + +D + + L ++ E+ +K+K +
Sbjct: 418 QLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK----V 473
Query: 1011 QKETELQTCLDQSRREWTMQEA--KRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDK 1068
TELQ LD+++++ Q+A + ++ + + D+ VL I D + K
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL---------RQIGDKDQK 524
Query: 1069 -QLLEIMSTCSSKWMSV--QYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSK-- 1123
Q LE + S + +S+ + E L IQ +T L + + +L++
Sbjct: 525 IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Query: 1124 DSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLC 1183
+ S+ Q Q L+A + V EL + N+ K K+ +L
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644
Query: 1184 KTPPR-SLSAGAIENA-------CLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKER 1235
K LSA A + A L + AL++ + + K ++ + +Q+ +E
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD-QVTAKLQDKQEH 703
Query: 1236 AAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMNAASKLATMAKLLET 1295
+++ E+ K K + L+Q + + EG KK+ A LE
Sbjct: 704 CSQL----------ESHLKEYKEKYLSLEQ--KTEELEGQIKKL---------EADSLEV 742
Query: 1296 PISSKSQSKTTQSALPLTSEM-LIAVKKSKRNDVNQKIPCC----IESKSNSVNTITRTL 1350
S + + Q L +++ L A + SK+ ++ ++I ++ KS ++ +I + L
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 1351 CEQAPKRR 1358
+Q +++
Sbjct: 803 TKQEEEKQ 810
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 108 bits (271), Expect = 3e-23
Identities = 214/1055 (20%), Positives = 439/1055 (41%), Gaps = 219/1055 (20%)
Query: 305 EAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQL---VDLHHSESLQRAREQHES 361
+++I L+ I+ LK N Q I + L++ QQ + H E L E+ E
Sbjct: 208 QSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEE 267
Query: 362 ------------IVMGLTKKYEEQ----VLSLQKNLDATVTALKEQEDICSRLKDHVKQL 405
I L+K YE Q VL ++K V + K+ E + ++KD K+L
Sbjct: 268 LENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEK-----VESTKKMEQLEDKIKDINKKL 322
Query: 406 E----------RNQEAIKLEKTEIINKLTR-SLEESQKQCAH-------------LLQSG 441
R QE + +EK +I+ + LE S+ Q + L QS
Sbjct: 323 SSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSA 382
Query: 442 SVQEVAQLQFQLQQA------------------------------QKAHAMSANMNKALQ 471
SV+EV +LQ L A +K ++ + + LQ
Sbjct: 383 SVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ 442
Query: 472 EELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEE 531
L +L +E + +S A I +L + L +L + ++ K++ + I + +
Sbjct: 443 MSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELN-QSISEKETLIAEIEELD 501
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKD---- 587
N+E +K ++K + Q+ G + ++S+L+ DL D K++ L K D
Sbjct: 502 RQNQEATKHMILIKDQLSKQQNEGDS-----IISKLKQDLNDEKKRVHQLEDDKMDITKE 556
Query: 588 -----EKSIEVE--------TKTDTSEKPKN---QLWPESSTSDVVRDDILLLKNEI--- 628
EK I+ E TK +K +N QL ++ ++ + L LK I
Sbjct: 557 LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616
Query: 629 ---------QVLQQQNQE---------LKETEGKLRNTNQDLC------NQMRQMVQDFD 664
+++Q NQ+ LKE E ++RN Q+L ++++ D
Sbjct: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676
Query: 665 HDKQEAVDRCERTYQQHHEAM---------KTQIRESL-LAKHALE------KQQLFE-- 706
+ ++ V CE Q E + K I E+L + K +E K++L E
Sbjct: 677 MENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736
Query: 707 -AYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELT-LRKTTEKEQQTQEKIKEK 764
YE+T +L S LN ++ +L +K ++E+ L+K E+ ++ K+
Sbjct: 737 NKYEKTIEEL-SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV 795
Query: 765 LIQQLEKEWQ-----SKLDQTIKAMKKKTLDCGSQTDQVTTS--------DVISKKEMAI 811
L LE++ Q +K + I+ +K+++ + D+ + + I +K+ ++
Sbjct: 796 LSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSL 855
Query: 812 -MIEEQKCTIQQNLEQEKDIAIKGA----MKKLEIELEL-----------KHCENITKQV 855
++E+ +Q+ LE+ ++ + A K L+ EL +H E K
Sbjct: 856 GSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHH 915
Query: 856 EIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELE 915
+ +++ +Q + L L E K E ++ QHE +N + E E E++
Sbjct: 916 QKIIEDQNQSKMQLLQSLQEQ----KKEMDEFRYQHE-QMNATHTQLFLEKDE----EIK 966
Query: 916 NMRKNILPGKELEEKIHSLQKELELKNEEV-----PVVIRAELAKARSEWNKEKQEEIHR 970
+++K I ++++ ++H +++++ N ++ + E + + +K + E + +
Sbjct: 967 SLQKTI---EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
Query: 971 IQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQ 1030
++ E + + L++ + + + +D + + T+++ QK+ E+Q + Q
Sbjct: 1024 GIKERELEIK-LLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQ 1082
Query: 1031 EAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQ-YFEK 1089
+ +Q ++ Y + V VL T++ +E ++++I++ + + +Q +K
Sbjct: 1083 DVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK 1142
Query: 1090 LKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQ 1149
L + + QD ++N +++ ++ D+ SQ LA+
Sbjct: 1143 LSTRFESSGQDMFRETIQNLSRIIREK---DIEIDALSQKC------------QTLLAVL 1187
Query: 1150 ATEAEAEE----NNKVVEELIEENNDMKNKLEELQ 1180
T + E N+ EEL++E + +K ++++++
Sbjct: 1188 QTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKME 1222
Score = 99.0 bits (245), Expect = 3e-20
Identities = 244/1210 (20%), Positives = 489/1210 (40%), Gaps = 168/1210 (13%)
Query: 229 NENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLR 288
N++S N + L K +E ++ NL + L+E E+ L +K E + L L+
Sbjct: 632 NQDSNSNFK----DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACE 687
Query: 289 ESQKLFQN--GKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDL 346
+ + + ++ LE +++ ++ E K R E A ++ + +L
Sbjct: 688 DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEA-NKYEKTIEEL 746
Query: 347 HHSESLQRAREQ--HESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQ 404
++ +L + Q HE ++ L +K + ++ L+KN++ T KE +D+ S + KQ
Sbjct: 747 SNARNLNTSALQLEHEHLIK-LNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQ 805
Query: 405 LER--NQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAM 462
L + N++ I +EK + + + L+E + + L+ + L+ +++ ++
Sbjct: 806 LTQLINKKEIFIEK---LKERSSKLQEELDKYSQALRKNEI-----LRQTIEEKDRSLGS 857
Query: 463 SANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTE------------SYV 510
N LQEEL L++E S +A DS EL E+++ +
Sbjct: 858 MKEENNHLQEELERLREEQS--RTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHH 915
Query: 511 DLGIKKVNWKKSKVTSIVQEEDPNEE-----------------LSKDEFILKLKAEVQRL 553
I+ N K ++ +QE+ + L KDE I L+ ++++
Sbjct: 916 QKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQI 975
Query: 554 LGSNSMKRHLVSQLQNDLKDCHK--KIEDLHQVKKDEKSIEVETKTDTSEKPKNQ----- 606
+R +Q D D + K++ L+ EK + +T+ K +
Sbjct: 976 KTQLHEERQ---DIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEI 1032
Query: 607 -LWPESSTSDVVRDDILLLKNEI----QVLQQQNQELKETEGKLRNTN--QDLCNQMRQM 659
L E + S + D L K+E+ Q++QQ++ E++ ++ +T+ QD+ ++Q
Sbjct: 1033 KLLNEKNISLTKQID-QLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVV-YLQQQ 1090
Query: 660 VQDFDHDKQEAVDRC-ERTYQQHHEAMKTQI---------RESLLAKHALEKQQLFEAYE 709
+Q + ++++ E+T + H +KT+ +E+ L K E ++L +E
Sbjct: 1091 LQAYAMEREKVFAVLNEKTRENSH--LKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFE 1148
Query: 710 RTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTE--------KEQQTQEKI 761
+ + E + + ++ ++ +K L + +T+ Q +E +
Sbjct: 1149 SSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL 1208
Query: 762 KE--KLIQQLEK--EWQSKLDQTIKAMKKKTLDCGSQTDQVTT-----SDVISKKEM--- 809
+E KL QQ++K EW+ ++ T++ M+ ++ + Q+ SD SK ++
Sbjct: 1209 QERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYT 1268
Query: 810 -AIMIEEQKCTIQQNLEQE--------------KDIAIKGAMKKLEI-ELELKHCENITK 853
I EQ T +N QE KD+ + KL+I +L +T
Sbjct: 1269 GLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLG----KLDIISPQLSSASLLTP 1324
Query: 854 QVEIAVQNAHQRWLGELPELA--EYQALVKAEQKKWEEQHEVSVNK-RISFAVSEAKEKW 910
Q ++ + L E EL E + L K+ Q+K + N R+S +++ E
Sbjct: 1325 QSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELE 1384
Query: 911 KSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHR 970
+ E E I K+L+EK LQK L+ K+ + L+ + NK + E+ R
Sbjct: 1385 RKEHEQTDSEI---KQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
Query: 971 IQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQ 1030
N ++ L+ K+ E + ++TE +ET ++ + +E+
Sbjct: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECH 1501
Query: 1031 EAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWM-------S 1083
K L Q + +KE E QLL + + K +
Sbjct: 1502 SMKEKALAFEQLLK-------------EKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQ 1548
Query: 1084 VQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHA 1143
V K K A Q+ + L D E++ E ++ + +
Sbjct: 1549 VMLALKQKQMENTALQNEVQRL---RDKEFRSNQELERLRNHLLESED--------SYTR 1597
Query: 1144 QPLALQATEAEAEENNKVVEE-LIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPC 1202
+ LA + EA+ + V+EE L+ +N M+N + ++ L+ + +
Sbjct: 1598 EALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETAL 1657
Query: 1203 SGGALEELRGQYIKAVKKIKCDMLRYIQESKER-AAEMVKAEVLRERQETARKMRKYYLI 1261
+E QY ++ ++ + + QE K +AE+ K + L + + + +I
Sbjct: 1658 QLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVI 1717
Query: 1262 CLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISS-KSQSKTTQSALPLTSEMLIAV 1320
LQ+ L + +++AS+L + E I K Q++ Q L + L+++
Sbjct: 1718 SLQECLDE------ANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSL 1771
Query: 1321 KKSKRNDVNQ 1330
S V++
Sbjct: 1772 ANSSEGKVDK 1781
Score = 76.6 bits (187), Expect = 2e-13
Identities = 206/954 (21%), Positives = 396/954 (41%), Gaps = 154/954 (16%)
Query: 376 SLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCA 435
S K ++A L+ + + RLK LE EA +++ + L++ + + +
Sbjct: 52 SRTKEIEAIHAILRSENE---RLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEIS 108
Query: 436 HLLQSGSVQEVAQLQFQLQQAQK-AHAMSANMNKALQEELTELKDEISLYESAAKLGIHP 494
HL +++A LQ QL + Q A ++ + + IS + SA H
Sbjct: 109 HL----KARQIA-LQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSA----FHD 159
Query: 495 SD--------SEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKL 546
D S+ E+N L+ L + +W+ TS Q D +++ I KL
Sbjct: 160 DDMDFGDIISSQQEIN-RLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSE----ICKL 214
Query: 547 KAEVQRLLGSNSMK----RHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEK 602
+ ++ L + S + +H +S LQN + +K+ ++ + ++E S + E + + E
Sbjct: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQ---QKLTEISRRHREELS-DYEERIEELEN 270
Query: 603 PKNQLWPESSTSDVVRDD---ILLLKNEIQVLQ----QQNQELKETEGKLRNTNQDLCNQ 655
Q S V+ D I ++ IQVLQ + +++++ E K+++ N+ L +
Sbjct: 271 LLQQ-----GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSA 325
Query: 656 ------MRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLF--EA 707
+R+ + + +K++ ++ CE + + + +++S EK+++ A
Sbjct: 326 ENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQS---DTMTEKERILAQSA 382
Query: 708 YERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLR-KTTEKEQQTQEKIKEKLI 766
+L+ L E+ + + +DNL+L +R + EKE+ + KE+L
Sbjct: 383 SVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ 442
Query: 767 QQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTI------ 820
L K + + IK+ + + S+ + + ++E+ I E++ I
Sbjct: 443 MSLLK--LNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEEL 500
Query: 821 -QQNLEQEKD-IAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQA 878
+QN E K I IK + K + E + + + + + HQ ++ E
Sbjct: 501 DRQNQEATKHMILIKDQLSKQQNEGD-SIISKLKQDLNDEKKRVHQLEDDKMDITKELDV 559
Query: 879 LVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKEL 938
QK+ Q EV++N + K+K + ++EN+ + K E + ++ L
Sbjct: 560 -----QKEKLIQSEVALND-----LHLTKQKLEDKVENLVDQL--NKSQESNVSIQKENL 607
Query: 939 ELK-----NEEVPVVIRAELAKARSEWN---------KEKQEEIHRIQEQNEQDYRQFLD 984
ELK NEE IR EL ++ ++ + KE++ E+ + +QN + Q L+
Sbjct: 608 ELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNL-KQNLSELEQ-LN 665
Query: 985 DHRNKI-------NEVLAAAKEDFMKQKTELLL---QKETELQTCLDQSRREWTMQEA-- 1032
++ K+ NE L A ED Q E L Q E T ++ + E EA
Sbjct: 666 ENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL 725
Query: 1033 ----KRIQLEIYQYE---EDILTVLGVLLSDTQKEH-----ISDSEDKQLLEIMSTCSSK 1080
KR+ E +YE E++ + S Q EH ++ +D ++ E+
Sbjct: 726 CWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ- 784
Query: 1081 WMSVQYFEK---LKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGP 1137
M + E L +++ Q L L+ KK E K+ +S+ + D
Sbjct: 785 -MDTDHKETKDVLSSSLEE--QKQLTQLIN------KKEIFIEKLKERSSKLQEELD--- 832
Query: 1138 AAGHHAQPLAL-QATEAEAEENNKVVEELIEENNDMKNKLEEL-----QTLCKTPPRSLS 1191
++Q L + EE ++ + + EENN ++ +LE L +T P++L
Sbjct: 833 ---KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLD 889
Query: 1192 AGAIENACLPCSGGALEELRGQYIKAVKKI-------KCDMLRYIQESKERAAE 1238
+ E A ++E + IK +KI K +L+ +QE K+ E
Sbjct: 890 S-VTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 108 bits (270), Expect = 4e-23
Identities = 232/1191 (19%), Positives = 502/1191 (42%), Gaps = 218/1191 (18%)
Query: 240 QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKE 299
+L ++ K++ ++ K E +++ L ++ KD+ + + + + FQN K
Sbjct: 769 ELHIITSEKDKLFSEVVHK----ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 300 REIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQL---------------V 344
+ E + K + + + + + K+++ + +L +LK +L
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 345 DLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQ 404
L+ E L+ E +S + + ++ LQ+ L+ T +E KD +KQ
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE--------KDDLKQ 936
Query: 405 LERNQEAIKLEKTEIINKLTRSLE---ESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHA 461
L QE++++E+ ++ + + ++ ++Q+Q + L+S + Q Q + + +
Sbjct: 937 L---QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES-----LKQHQETINTLKSKIS 988
Query: 462 MSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESY-VDLGIKKVNWK 520
+ N ++E E KDE +GI D + +L + T++ D+ ++ +
Sbjct: 989 EEVSRNLHMEENTGETKDEF----QQKMVGI---DKKQDLEAKNTQTLTADVKDNEIIEQ 1041
Query: 521 KSKVTSIVQEEDPNEEL------SKDEFILKLKAEVQ---------RLLGSNSMKRHLV- 564
+ K+ S++QE++ +++ K++ LK ++ RLLG K+ +
Sbjct: 1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 565 ---------------------SQLQNDLKDCHKKIEDLHQ--VKKDEKSIEVETKTDTSE 601
++++ LK+ +++++ Q + E+ E++ K + E
Sbjct: 1102 AQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
Query: 602 KPKNQLWPESSTSDVVRDDILLLK-------NEIQVLQQQNQELKETEGKLRNTNQDLCN 654
KN+L + T + + + L L E++ + ++ + LKE + L
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
Query: 655 QMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHA--LEKQQLFEAYERTH 712
+R++ K+E + + + H+ ++R S+ K A + Q L E++H
Sbjct: 1222 YIREIEATGLQTKEEL--KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL----EKSH 1275
Query: 713 LQLRSELDKLNKE---VTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQL 769
+L+ E+ L++E + V+E E + LEL ++T K+ T +I+ + ++
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKE-VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLN 1334
Query: 770 EKEWQSKLDQTIKAMKK-----KTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNL 824
EK +S+ + IK++ K KT+ + + I +E I+E + +Q+L
Sbjct: 1335 EKFQESQ--EEIKSLTKERDNLKTIKEALEVKHDQLKEHI--RETLAKIQESQSKQEQSL 1390
Query: 825 E-QEKDIAIKGAMKKLEIELELKHCENITKQVEI-------AVQNAHQRWLG---ELPEL 873
+EKD + ++E + K ++ ++EI +Q +H E +L
Sbjct: 1391 NMKEKDNETTKIVSEME---QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 874 AEYQALVKAEQKKWEEQHEVSVNKRI----SFAVSEAKEKWKSE-LENMRKNILPGKELE 928
Q ++++E + +E + V K + V+ K + E + +R N+ E E
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL---SEKE 1504
Query: 929 EKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQ--DYRQFLDDH 986
+I ++QK+LE N+++ K + + KE+Q I +I E E+ + +QF +H
Sbjct: 1505 TEISTIQKQLEAINDKLQ-------NKIQEIYEKEEQFNIKQISEVQEKVNELKQF-KEH 1556
Query: 987 RNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDI 1046
R + L + E M + T L + + E+Q + + +QEA +Q+E Q +E+
Sbjct: 1557 RKAKDSALQSI-ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA--LQIERDQLKENT 1613
Query: 1047 LTVLGVLLSDTQKEH-------ISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQ 1099
++ + +KE+ ++++++K C + + Q+
Sbjct: 1614 KEIVAKMKESQEKEYQFLKMTAVNETQEKM-------CEIEHLKEQF------------- 1653
Query: 1100 DTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENN 1159
+T L +EN + E + ++ ++ + +++ E ++
Sbjct: 1654 ETQKLNLENIETE--NIRLTQILHENLEE-------------------MRSVTKERDDLR 1692
Query: 1160 KVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVK 1219
V E L E + +K L E T L I + L +++LRG +
Sbjct: 1693 SVEETLKVERDQLKENLRETITRDLEKQEELK---IVHMHLKEHQETIDKLRG-----IV 1744
Query: 1220 KIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKI 1279
K + + +Q+ E + + +KA+ L+ ++E +R ++ +Q D G +
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEE----LRIAHMHLKEQQETIDKLRGI---V 1797
Query: 1280 MNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSKRNDVNQ 1330
KL+ M K LE ++K Q K + L LI +KK DVN+
Sbjct: 1798 SEKTDKLSNMQKDLENS-NAKLQEKIQE--LKANEHQLITLKK----DVNE 1841
Score = 106 bits (265), Expect = 2e-22
Identities = 231/1228 (18%), Positives = 506/1228 (41%), Gaps = 190/1228 (15%)
Query: 221 LQQQFLGANENSAENMQII--QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKD 278
+Q+Q N+ +Q I + + N + +++ + +L + + + + L I+
Sbjct: 1510 IQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIES 1569
Query: 279 EKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTT-EMALE 337
+ LT L+ESQ+ Q + + +++ +AL+ + LK N ++++ K + + E +
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629
Query: 338 SLKQQLVDLHHSE--SLQRAREQHESIVMGLTKKYEEQVLSLQ---KNLDATVTALKEQE 392
LK V+ + ++ +EQ E+ + L E + Q +NL+ + KE++
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689
Query: 393 DICS---RLKDHVKQLERN-QEAIK--LEKTEIINKLTRSLEESQKQCAHL--LQSGSVQ 444
D+ S LK QL+ N +E I LEK E + + L+E Q+ L + S
Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTN 1749
Query: 445 EVAQLQFQLQQAQKA-HAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNI 503
E++ +Q L+ + A A + + L+ LK++ + + +D +
Sbjct: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809
Query: 504 ELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHL 563
+L S L K K ++ I ++D NE K + +LK +++ S ++ +
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQ--SLTLSKLE 1867
Query: 564 VSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILL 623
+ L N + H+ +E++ V K+ ++ + + + K + ES RD L
Sbjct: 1868 IENL-NLAQKLHENLEEMKSVMKERDNLR---RVEETLKLERDQLKESLQETKARD--LE 1921
Query: 624 LKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHE 683
++ E++ + ++E KET KLR + Q+ + +D D K E + + ++ +
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 684 AMKTQIRESLLAKHALEKQQLFEAYERTHL----------QLRSELDKLNKEVTAVQECY 733
++ + ++ K E +QL + +E +L QL +L + +E+ V +
Sbjct: 1982 LLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKER 2041
Query: 734 LEVCREKDNLEL-------TLRKTTEKEQQTQEKIKEKLI-----QQLEKEWQSKLDQTI 781
E+ R K++L++ TLR+ +++Q + EK + Q L + + K +
Sbjct: 2042 DELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIK 2101
Query: 782 KAMKKKT-----LDCGSQTDQVTTSDVISKKEMAIMIE-------------------EQK 817
+ +K+ + +C ++ ++ +KE+++ ++ Q+
Sbjct: 2102 ELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQR 2161
Query: 818 CTIQQNLEQEKDIAIKGAMKKLEIE-------LELKHCENITKQVEIAVQNAH------- 863
C+++ + +K + + K++ E E+ + + KQ E+ ++ H
Sbjct: 2162 CSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDV 2221
Query: 864 -QRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKE--KWKSELENMRKN 920
R L +L ++ K + E S+ +S KE ++ E N R +
Sbjct: 2222 PSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD 2281
Query: 921 ILPGKELEEKIHSLQKELE--------LKNEEVPVVIRAELAKARSEW-NKEKQEEIHRI 971
I E+ + +QKE + N + ++ + + RS +KE ++++ +
Sbjct: 2282 I------EKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSL 2335
Query: 972 QEQNEQDYRQFLDDHRN-----KINEVLAAAKEDFMKQK-TELLLQKETELQTCLDQSRR 1025
+E+NE+ ++ + + ++N K + + T+L +K EL+ L +++
Sbjct: 2336 KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKE 2395
Query: 1026 EWTMQEAKRIQLE-IYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSV 1084
+E+K I+++ + DI+ L + ++ K E Q+L+ +K
Sbjct: 2396 SAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAK---- 2451
Query: 1085 QYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQ 1144
Y E+++ K + L K +N E K+
Sbjct: 2452 PYKEEIEDLKMKLVKIDLE----------KMKNAKEFEKE-------------------- 2481
Query: 1145 PLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCK-TPPRSLSAGAIENACLPCS 1203
+ AT+A E +V+ L+ EN + ++ + + T P+ N L C
Sbjct: 2482 ---ISATKATVEYQKEVI-RLLRENLRRSQQAQDTSVISEHTDPQP------SNKPLTCG 2531
Query: 1204 GGA--LEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLI 1261
GG+ ++ + +K+ + I+ + + I + K++ +++K +K L+
Sbjct: 2532 GGSGIVQNTKALILKS-EHIRLE--KEISKLKQQNEQLIK--------------QKNELL 2574
Query: 1262 CLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVK 1321
Q L ++ K E+ + A K T ++P + + SK Q I
Sbjct: 2575 SNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQ----------ITPS 2624
Query: 1322 KSKRNDVNQKIP------CCIESKSNSV 1343
+ K ++ +P C +S+S S+
Sbjct: 2625 QCKERNLQDPVPKESPKSCFFDSRSKSL 2652
Score = 103 bits (258), Expect = 1e-21
Identities = 235/1247 (18%), Positives = 511/1247 (40%), Gaps = 194/1247 (15%)
Query: 253 ENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ-------NGKEREIQLE 305
EN+ +LN L ++ EK+ + L L+E L + K++E+QL
Sbjct: 494 ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLI 553
Query: 306 AQIKALETQIQALKVNEEQM-------IKKSRTTEMALESLKQQL---------VDLHHS 349
+I L+ ++ +V + + ++ R E ++ L++ + +DL +S
Sbjct: 554 HEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYS 613
Query: 350 -ESLQRAREQHESI----VMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQ 404
ES++ ++ +++ + L K E L +NL+ +KE ++++ ++
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAFLR-SENLELK-EKMKELATTYKQMENDIQL 671
Query: 405 LERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVA----QLQFQLQQAQKAH 460
+ EA K + ++ +L + E K + L G V + +L+ ++ QK
Sbjct: 672 YQSQLEAKKKMQVDLEKELQSAFNEITKLTS--LIDGKVPKDLLCNLELEGKITDLQKEL 729
Query: 461 AMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWK 520
N+AL+EE+ L + SL +L D EL+I +E D +V K
Sbjct: 730 NKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEK--DKLFSEVVHK 787
Query: 521 KSKVTSIVQE----------EDPNEELSKDEF------ILKLKAEVQRLLGSNSMKRHLV 564
+S+V +++E N + + EF + + + + +L N +
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN---ERMN 844
Query: 565 SQLQNDLKDCHKKIEDLHQVKKD---------EKSIEVETKTDTSEKPKNQLWPESSTSD 615
++ N K+ K L +K + EK+ EV+ + + E+ K QL ST
Sbjct: 845 QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQ 904
Query: 616 VVRDDILLLK-------NEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQ 668
V + L+ E++ L Q+ +LK+ + L+ L + + V + + D Q
Sbjct: 905 TVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV-NMNIDTQ 963
Query: 669 EAVDRCERTYQQHHE---AMKTQIRESLLAKHALE----------KQQLFEAYERTHLQL 715
E + + +QH E +K++I E + +E +Q++ ++ L+
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023
Query: 716 RS----ELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEK 771
++ D + E+ Q + +EK+ L+ L +++Q + +KE + +E
Sbjct: 1024 KNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN 1083
Query: 772 EWQSKL-------DQTIKAMKK-----------KTLDCGSQTDQ---VTTSDVISKKEMA 810
+ + +L Q I A +K +T D ++ ++ + + K++
Sbjct: 1084 QEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQL 1143
Query: 811 IMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGEL 870
+ ++E+ +Q+ + + ++ +K +K E+ LE H E T+++E+A Q ++ + E+
Sbjct: 1144 LNVQEEMSEMQKKINEIEN--LKNELKNKELTLE--HME--TERLELA-QKLNENY-EEV 1195
Query: 871 PELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEK 930
+ + + ++K QK +E + + + + E + E ++ + KE +E
Sbjct: 1196 KSITKERKVLKELQKSFETERD-----HLRGYIREIEATGLQTKEELKIAHIHLKEHQET 1250
Query: 931 IHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNE-QDYRQFLDDHRNK 989
I L++ + K + ++ +L K+ + + QEEI + E+ E + + + +
Sbjct: 1251 IDELRRSVSEKTAQ--IINTQDLEKSHT----KLQEEIPVLHEEQELLPNVKEVSETQET 1304
Query: 990 INEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTV 1049
+NE+ ++ K T L E++ + + + +E K + E +++ T+
Sbjct: 1305 MNELELLTEQSTTKDSTTL---ARIEMERLRLNEKFQESQEEIKSLTKE----RDNLKTI 1357
Query: 1050 LGVL--LSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVE 1107
L D KEHI ++ L +I + S + S+ EK D +
Sbjct: 1358 KEALEVKHDQLKEHIRET----LAKIQESQSKQEQSLNMKEK----------DNETTKIV 1403
Query: 1108 NADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIE 1167
+ ++K ++ A L + G + H + +++ E ++ ++ E L
Sbjct: 1404 SEMEQFKPKDSALLRIEIEMLGLSK----RLQESHDE---MKSVAKEKDDLQRLQEVLQS 1456
Query: 1168 ENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELR----------GQYIKA 1217
E++ +K ++E+ L + + CL + ELR K
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELK---VAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 1218 VKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEK 1277
++ I + IQE E+ E + + E QE +++++ + +D + E
Sbjct: 1514 LEAINDKLQNKIQEIYEK-EEQFNIKQISEVQEKVNELKQFK---EHRKAKDSALQSIES 1569
Query: 1278 KIMNAASKLATMAKLLETPISSKSQSKTTQSALPL--------TSEMLIAVKKSKRNDVN 1329
K++ ++L + ++ I K + K Q AL + T E++ +K+S+ +
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629
Query: 1330 QKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIK 1376
K +VN +CE + + LEN E ++I+
Sbjct: 1630 -------FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIR 1669
Score = 58.2 bits (139), Expect = 7e-08
Identities = 178/897 (19%), Positives = 333/897 (37%), Gaps = 178/897 (19%)
Query: 517 VNWKKSKVTSIVQEEDPNEE----------LSKDEFILKLKAEVQRLLGSNSMKRHLVSQ 566
+N++ SK+T I+Q +S DE + L+ N+ + VS
Sbjct: 281 INYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVST 340
Query: 567 LQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPK-NQLWPESSTSDVVRDDILLLK 625
+ LK K+I DL KK + + +ET+ EK + QL E V+++ +
Sbjct: 341 DEALLKRYRKEIMDL---KKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENL 397
Query: 626 NEIQVLQQQ---NQELKETEGKLRNTNQDLCNQMRQM--VQDFDHDKQEAVDRCERTYQQ 680
+ V QELK + N+M+ F+ + +
Sbjct: 398 TRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL 457
Query: 681 HHEAMKTQIRESLLAKHALEKQQLFEAYERTHL----QLRSELDKLNKEVTAVQECYLEV 736
E ++ ES + + L+ E T L + SEL+ L + + Y ++
Sbjct: 458 LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQL 517
Query: 737 CREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTD 796
EK+ +EL L++ + ++ E L ++ +K+ + +L I +K + +
Sbjct: 518 RTEKEEMELKLKEKNDLDEF------EALERKTKKDQEMQLIHEISNLKN-LVKHAEVYN 570
Query: 797 QVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKG----AMKKLEIELELKHCENIT 852
Q +++ SK E+ E+Q +Q+ ++ +K IK +++ +E ++K
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 853 KQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEE-----QHEVSVNKRISFAVSEAK 907
+ V + + E EL E + K+ E Q ++ K++ + +
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
Query: 908 EKWKSELENMR--------KNILPGKELEEKIHSLQKELELKNEE-----VPVVIRAELA 954
+ +E+ + K++L ELE KI LQKEL + EE V++ +EL
Sbjct: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELK 750
Query: 955 KARSEWNK------EKQEEIHRIQEQN--------------------------------- 975
SE + +K EE+H I +
Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS 810
Query: 976 -------------------EQDYRQFLDDHRNKINEVLAAAKE------------DFMKQ 1004
EQ Y+ L+++ E++ +KE +
Sbjct: 811 NYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870
Query: 1005 KTELLLQKETELQTCLDQ--------SRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSD 1056
KT+ L +K E+Q L++ R+ T+Q +R + I + + L + L +
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930
Query: 1057 TQ-----KEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQ--KAFQDTLPLLVENA 1109
+E + D+ +I T + M++ E+L+ ++ K Q+T+ L
Sbjct: 931 KDDLKQLQESLQIERDQLKSDIHDTVN---MNIDTQEQLRNALESLKQHQETINTLKSKI 987
Query: 1110 DPEWKK-----RNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEE 1164
E + N E + + G + Q L + E E + +
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS 1047
Query: 1165 LIEENNDMKNKLEEL---QTLCKTPPRSLSAGAIENACLPCSGGALEELR--GQYIK--- 1216
LI+E N+++ LE + + KT + IEN EELR G +K
Sbjct: 1048 LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQ---------EELRLLGDELKKQQ 1098
Query: 1217 ---------AVKK-----IKCDMLRYIQES-KERAAEM-VKAEVLRERQETARKMRK 1257
A+KK CD L ++E KE++ ++ K + L QE +M+K
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK 1155
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 106 bits (265), Expect = 2e-22
Identities = 207/1051 (19%), Positives = 427/1051 (40%), Gaps = 164/1051 (15%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER-------E 301
+ + + + ++L +SE + + L ++V + EK+ L L ++ + + +ER +
Sbjct: 859 KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTK 918
Query: 302 IQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHS-ESLQRAREQHE 360
IQLEA+IK + + + + ++ K R E LK+ + DL + +++ + E
Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978
Query: 361 SIVMGLTKK---YEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKT 417
+ V LT++ +E + L K A A ++ D +D V L + + IKLE+
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK--IKLEQQ 1036
Query: 418 EIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTEL 477
++ L SLE+ +K L+ + +L+ L+ AQ++ N + L E+L +
Sbjct: 1037 --VDDLEGSLEQEKK-----LRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 478 KDEISLYESAAK----LGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDP 533
+ EIS +S + LGI EL + E ++ ++ + K++ Q D
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE----KQRSDL 1145
Query: 534 NEELSK-DEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDC---HKKIEDLHQVKKDEK 589
+ EL + E + + + N + +++ DL++ H+ + K +
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 590 SIEVETKTDTSEKPKNQLWPESSTSDVVRDDILL-----------LKNEIQVLQQQNQEL 638
E+ + D ++ K +L E S + DD+ L+ + L+ Q EL
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 639 KETEGKLRNTNQDLCNQMRQMVQDFDH-----DKQEA----VDRCERTYQQHHEAMKTQI 689
K E + + DL Q ++ + D++EA + R ++ + Q E +K Q+
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 690 RESLLAKHALEK------------QQLFEAYERTHLQLRSELDKLNKEVTAVQECY-LEV 736
E + AK+AL ++ +E + + +L+ L K N EV + Y +
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 737 CREKDNLELTLRKTTEKEQQTQ-------------EKIKEKLIQQLE------------- 770
+ + LE +K ++ Q + EK K++L ++E
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445
Query: 771 --------------KEWQSKLDQT---IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMI 813
EW+ K ++T ++A +K+ G++ ++ + S ++ +
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 814 EEQKCTIQQNLEQEKDIAIKG----AMKKLEIELELKHCENITKQVEIAVQNAHQRWLGE 869
E K Q+ + + IA G ++K++ ++E + CE E H+
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565
Query: 870 LPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEK-WKSELENMRKNILPGKELE 928
+L Q + ++K E+ E+ KR + E+ + +E+ + I K++E
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 929 EKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDD--- 985
++ ++ +L N +R R+ K +IH LDD
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALR----NYRNTQGILKDTQIH-------------LDDALR 1668
Query: 986 HRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQE------AKRIQLEI 1039
+ + E LA ++++ LL + EL+ L+Q+ R + E ++R+QL
Sbjct: 1669 SQEDLKEQLA-----MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1723
Query: 1040 YQ----------YEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQ---- 1085
Q E DI + G + Q+ ++ + K+ + + + + Q
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 1086 YFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQP 1145
+ E++K +++ +D L L ++ A+ K ++ K A +G+ +A
Sbjct: 1784 HLERMKKNMEQTVKD-LQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNA-- 1840
Query: 1146 LALQATEAEAEENNKVVEELIEENNDMKNKL 1176
+A + + +V E + D KN L
Sbjct: 1841 ---EAVKGLRKHERRVKELTYQTEEDRKNIL 1868
Score = 99.4 bits (246), Expect = 3e-20
Identities = 168/803 (20%), Positives = 350/803 (43%), Gaps = 111/803 (13%)
Query: 285 LSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLV 344
L E++K KE +++ ++ E + + L+ ++K+ ++ +++ + L
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 345 DLHHS-ESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQ-EDICSRLKDHV 402
D + L + + Q E+ + +T++ E++ + ++A +TA K + ED CS LK +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDE-----EEINAELTAKKRKLEDECSELKKDI 960
Query: 403 KQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAM 462
LE ++ EK NK+ EE +G + +A+L + + Q+AH
Sbjct: 961 DDLELTLAKVEKEKHATENKVKNLTEE---------MAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 463 SANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKS 522
+ + +A ++++ +L ++ KL D EG L E + + +++ K
Sbjct: 1012 TLDDLQAEEDKVN------TLTKAKIKLEQQVDDLEGSLE---QEKKLRMDLERAKRKLE 1062
Query: 523 KVTSIVQE---EDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIE 579
+ QE + NE+ DE + K + E+ L ++ L QLQ +K+ +IE
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 580 DLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELK 639
+L + E+E + + K + Q SD+ R+ L++ ++ L+
Sbjct: 1123 ELEE--------EIEAERASRAKAEKQ------RSDLSRE-----------LEEISERLE 1157
Query: 640 ETEGKLRNTNQDLCNQMRQM-VQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHA 698
E G + Q N+ R+ Q D +EA + E T + + E L +
Sbjct: 1158 EAGG--ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE--LGEQI 1213
Query: 699 LEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQ 758
Q++ + E+ +++ E+D L V V + + + LE L + KE++ Q
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 759 EKIKEKLIQ----QLEK-EWQSKLDQTIKAMKKKTLDCGSQTDQV------TTSDVISKK 807
I + Q Q E E+ +LD+ + + + + T Q+ ++ +K
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKN 1333
Query: 808 EMAIMIEEQK--CTI---QQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNA 862
+A ++ + C + Q EQE ++ A+ K E+ + TK A+Q
Sbjct: 1334 ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEV----AQWRTKYETDAIQRT 1389
Query: 863 HQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNI- 921
EL E + + A++ + E+H +VN + + ++ + K++ ++E+E++ ++
Sbjct: 1390 E--------ELEEAKKKL-AQRLQAAEEHVEAVNAKCA-SLEKTKQRLQNEVEDLMLDVE 1439
Query: 922 ---LPGKELEEKIHSLQK---ELELKNEEVPVVIRAELAKARS---------EWNKEKQE 966
L++K + K E + K EE + A +ARS +E +
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 967 EIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKE-DFMKQKTELLLQKETELQTCLDQSRR 1025
++ ++ +N ++ +Q + D +I E E + +K++ E Q++ ELQ L+++
Sbjct: 1500 QLETLKREN-KNLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEA 1555
Query: 1026 EWTMQEAK--RIQLEIYQYEEDI 1046
+E K RIQLE+ Q + ++
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEV 1578
Score = 94.0 bits (232), Expect = 1e-18
Identities = 192/894 (21%), Positives = 363/894 (40%), Gaps = 150/894 (16%)
Query: 230 ENSAENMQIIQLQVLNKAKERQLENLIEKLNES----ERQIRYLNHQLVIIKDEKDGLTL 285
E S E + +++ L +AK R+LE ++ ES E + + L+ +L + E L
Sbjct: 1041 EGSLEQEKKLRMD-LERAK-RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 286 SLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD 345
+ + Q L +++ +L+A+I+ LE +I+A + + + K+ LE + ++L +
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 346 LHHSES-------------------LQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVT 386
+ S L+ A QHE+ L KK+ + V L + +D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 387 ALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSL----------EESQKQCAH 436
++ E S +K + L N E + K + K+ R+L EE Q++ +
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSELKSKEEEQQRLIN 1277
Query: 437 LL--QSGSVQ-EVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIH 493
L Q G +Q E + QL + + + + +A +++ ELK ++ A H
Sbjct: 1278 DLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAH 1337
Query: 494 PSDS--------------EGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSK 539
S E E EL + + W+ T +Q + EE +K
Sbjct: 1338 ALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEE-AK 1396
Query: 540 DEFILKLKAEVQRLLGSNSMKRHL---VSQLQNDLKDCHKKIE---------DLHQVKKD 587
+ +L+A + + N+ L +LQN+++D +E D Q D
Sbjct: 1397 KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1456
Query: 588 -------EKSIEVETKTDTSEKPKNQLWPE----SSTSDVVRDDILLLKNEIQVLQQQNQ 636
+K E + + S+K L E + + D + LK E + LQQ+
Sbjct: 1457 KILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 637 ELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIR------ 690
+L E + +L ++++ V+ + Q A++ E + +H E +I+
Sbjct: 1517 DLTEQIAEGGKRIHEL-EKIKKQVEQEKCELQAALEEAEASL-EHEEGKILRIQLELNQV 1574
Query: 691 ESLLAKHALEKQQLFEAYERTHL-------------------------QLRSELDKLNKE 725
+S + + EK + + +R H+ ++ +L+++ +
Sbjct: 1575 KSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ 1634
Query: 726 VTAVQECYLEVCREKDNLELTLRKT---TEKEQQTQEKIKEK---------LIQQLEKEW 773
+ E R N + L+ T + ++QE +KE+ L+Q +E
Sbjct: 1635 LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEEL 1694
Query: 774 QSKLDQTIKAMK---KKTLDCGSQTDQV---TTSDVISKKEMAIMIEEQKCTIQQNLEQE 827
++ L+QT ++ K ++ LD + + TS + +KK++ I + + ++ L++
Sbjct: 1695 RATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEA 1754
Query: 828 KDIAIK-------GAMKKLEIELE---LKHCENITKQVEIAVQNAHQRWLGELPELA--- 874
++ K AM E++ E H E + K +E V++ R L E +LA
Sbjct: 1755 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR-LDEAEQLALKG 1813
Query: 875 EYQALVKAEQKKWEEQHEV-SVNKRISFAVSEAK--EKWKSEL----ENMRKNILPGKEL 927
+ + K E + E + EV S KR + AV + E+ EL E RKNIL ++L
Sbjct: 1814 GKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 928 EEKIHSLQKELELKNEEVPVVIRAELAKARS-EWNKEKQEEIHRIQEQNEQDYR 980
+K+ + K + + EE LAK R + E+ EE I E R
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Score = 89.4 bits (220), Expect = 3e-17
Identities = 181/938 (19%), Positives = 400/938 (42%), Gaps = 128/938 (13%)
Query: 188 EPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENM----QIIQLQV 243
E + K+ + +S A+ + +T LQ Q E A+ Q+I+ ++
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 244 LNKAKERQLENLIEKLNESERQI----RYLNHQLVIIKDEKDGLTLSLRESQK------- 292
+AK +++ E E ++ R L + +K + D L L+L + +K
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 293 LFQNGKEREIQLEAQIKALETQIQALKVNEEQMIK-------KSRTTEMALESLKQQLVD 345
+N E L+ I L + +AL+ +Q + K T A L+QQ+ D
Sbjct: 980 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 346 LHHS----ESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDH 401
L S + L+ E+ + + G K +E ++ ++ LK++E S L+
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Query: 402 VKQLERNQEAIKLEKTEIINKLTRSLEESQKQC---------AHLLQSGSVQEVAQLQFQ 452
++ +++A+ ++ + I +L +EE +++ A +S +E+ ++ +
Sbjct: 1100 IE----DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155
Query: 453 LQQAQKAHAMSANMNKALQEELTELK---DEISLYE--SAAKLGIHPSDSEGELNIELTE 507
L++A A + MNK + E +++ +E +L +AA L +DS EL ++
Sbjct: 1156 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID- 1214
Query: 508 SYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQL 567
+++V K K S ++ E ++ S E + K K ++++ + +S+L
Sbjct: 1215 -----NLQRVKQKLEKEKSEMKME-IDDLASNVETVSKAKGNLEKMCRT---LEDQLSEL 1265
Query: 568 QNDLKDCHKKIEDLH------QVKKDEKSIEVETK--------------TDTSEKPKNQL 607
++ ++ + I DL Q + E S +++ K T E+ K QL
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 608 WPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHD- 666
E + + + +++ +L++Q +E +E++ +L+ ++ Q ++ D
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 667 --KQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNK 724
+ E ++ ++ Q +A + + E++ AK A + E+T +L++E++ L
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHV-EAVNAKCA--------SLEKTKQRLQNEVEDLML 1436
Query: 725 EVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKL---------IQQLEKEWQS 775
+V + +++ N + L + +K ++T +++ + +++ ++
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 776 KLDQ--TIKAMKKK-TLDCGSQTDQVTTSD--VISKKEMAIMIEEQKCTIQQNLEQEKDI 830
LDQ T+K K + T+Q+ + +++ +E++KC +Q LE+ +
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 831 AIKGAMKKLEIELELKHCEN------ITKQVEI-AVQNAHQRWLGELPELAEYQALVKAE 883
K L I+LEL ++ K EI ++ H R + + + + + +
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 884 QKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIH---SLQKELEL 940
+ +++ E +N+ + ++ A L N R G + +IH +L+ + +L
Sbjct: 1617 AIRLKKKMEGDLNE-MEIQLNHANRMAAEALRNYRNT--QGILKDTQIHLDDALRSQEDL 1673
Query: 941 KNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKED 1000
K + V RA L +A E + E+ R ++ EQ + LD A+ +
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ---ELLD----------ASERVQ 1720
Query: 1001 FMKQKTELLLQKETELQTCLDQSRREW--TMQEAKRIQ 1036
+ + L+ + +L+T + Q + E +QEA+ +
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758
Score = 76.6 bits (187), Expect = 2e-13
Identities = 146/725 (20%), Positives = 300/725 (41%), Gaps = 143/725 (19%)
Query: 617 VRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCER 676
++++ +K+E+ + + +EL+E L DL Q++ + +A +RC+
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL----ADAEERCD- 912
Query: 677 TYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEV 736
+ +KT+I+ K E+ E E + +L ++ KL E + E+
Sbjct: 913 ------QLIKTKIQLEAKIKEVTERA---EDEEEINAELTAKKRKLEDECS-------EL 956
Query: 737 CREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAM--KKKTLDCGSQ 794
++ D+LELTL K +++ T+ K+K E + LD+TI + +KK L +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLT------EEMAGLDETIAKLTKEKKALQ---E 1007
Query: 795 TDQVTTSDVISKKEMA-------IMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKH 847
Q T D+ ++++ I +E+Q ++ +LEQEK + + K ++E +LK
Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 848 CENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAK 907
+ +E Q ++ + E++ Q+ ++ EQ + + K+I
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQAL-----GIQLQKKI-------- 1114
Query: 908 EKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEE 967
KEL+ +I L++E+E + RA+ K RS+ ++E +E
Sbjct: 1115 -----------------KELQARIEELEEEIEAERAS-----RAKAEKQRSDLSRELEEI 1152
Query: 968 IHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREW 1027
R++E Q NK E +F K + +L +E LQ
Sbjct: 1153 SERLEEAGGATSAQI---EMNKKREA------EFQKMRRDL---EEATLQ---------- 1190
Query: 1028 TMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYF 1087
EA L + D + LG + + Q+ + +K+ E+ +V+
Sbjct: 1191 --HEATAATLR--KKHADSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDDLASNVETV 1244
Query: 1088 EKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLA 1147
K KG ++K + L E E +++ + ++ +A +G Q + G +
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRL--INDLTAQRGRLQTESGEFSRQ------ 1296
Query: 1148 LQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGAL 1207
L EA + ++ + ++ ++K +LEE + ++ A A++++
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALAHALQSS--------- 1342
Query: 1208 EELRGQYIKAVKKIKCDMLR-YIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQI 1266
+ CD+LR +E +E AE+ +A + + E A+ KY +Q+
Sbjct: 1343 ------------RHDCDLLREQYEEEQESKAELQRA-LSKANTEVAQWRTKYETDAIQRT 1389
Query: 1267 LQ-DDGKEGAEKKIMNAASKL----ATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVK 1321
+ ++ K+ +++ A + A A L +T +++ + + T+ A+
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 1322 KSKRN 1326
K +RN
Sbjct: 1450 KKQRN 1454
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 106 bits (265), Expect = 2e-22
Identities = 207/1051 (19%), Positives = 427/1051 (40%), Gaps = 164/1051 (15%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER-------E 301
+ + + + ++L +SE + + L ++V + EK+ L L ++ + + +ER +
Sbjct: 859 KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTK 918
Query: 302 IQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHS-ESLQRAREQHE 360
IQLEA+IK + + + + ++ K R E LK+ + DL + +++ + E
Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978
Query: 361 SIVMGLTKK---YEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKT 417
+ V LT++ +E + L K A A ++ D +D V L + + IKLE+
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK--IKLEQQ 1036
Query: 418 EIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTEL 477
++ L SLE+ +K L+ + +L+ L+ AQ++ N + L E+L +
Sbjct: 1037 --VDDLEGSLEQEKK-----LRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKK 1089
Query: 478 KDEISLYESAAK----LGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDP 533
+ EIS +S + LGI EL + E ++ ++ + K++ Q D
Sbjct: 1090 EFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE----KQRSDL 1145
Query: 534 NEELSK-DEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDC---HKKIEDLHQVKKDEK 589
+ EL + E + + + N + +++ DL++ H+ + K +
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 590 SIEVETKTDTSEKPKNQLWPESSTSDVVRDDILL-----------LKNEIQVLQQQNQEL 638
E+ + D ++ K +L E S + DD+ L+ + L+ Q EL
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 639 KETEGKLRNTNQDLCNQMRQMVQDFDH-----DKQEA----VDRCERTYQQHHEAMKTQI 689
K E + + DL Q ++ + D++EA + R ++ + Q E +K Q+
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 690 RESLLAKHALEK------------QQLFEAYERTHLQLRSELDKLNKEVTAVQECY-LEV 736
E + AK+AL ++ +E + + +L+ L K N EV + Y +
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 737 CREKDNLELTLRKTTEKEQQTQ-------------EKIKEKLIQQLE------------- 770
+ + LE +K ++ Q + EK K++L ++E
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445
Query: 771 --------------KEWQSKLDQT---IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMI 813
EW+ K ++T ++A +K+ G++ ++ + S ++ +
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 814 EEQKCTIQQNLEQEKDIAIKG----AMKKLEIELELKHCENITKQVEIAVQNAHQRWLGE 869
E K Q+ + + IA G ++K++ ++E + CE E H+
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565
Query: 870 LPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEK-WKSELENMRKNILPGKELE 928
+L Q + ++K E+ E+ KR + E+ + +E+ + I K++E
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 929 EKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDD--- 985
++ ++ +L N +R R+ K +IH LDD
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALR----NYRNTQGILKDTQIH-------------LDDALR 1668
Query: 986 HRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQE------AKRIQLEI 1039
+ + E LA ++++ LL + EL+ L+Q+ R + E ++R+QL
Sbjct: 1669 SQEDLKEQLA-----MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1723
Query: 1040 YQ----------YEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQ---- 1085
Q E DI + G + Q+ ++ + K+ + + + + Q
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 1086 YFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQP 1145
+ E++K +++ +D L L ++ A+ K ++ K A +G+ +A
Sbjct: 1784 HLERMKKNMEQTVKD-LQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNA-- 1840
Query: 1146 LALQATEAEAEENNKVVEELIEENNDMKNKL 1176
+A + + +V E + D KN L
Sbjct: 1841 ---EAVKGLRKHERRVKELTYQTEEDRKNIL 1868
Score = 99.4 bits (246), Expect = 3e-20
Identities = 168/803 (20%), Positives = 350/803 (43%), Gaps = 111/803 (13%)
Query: 285 LSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLV 344
L E++K KE +++ ++ E + + L+ ++K+ ++ +++ + L
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905
Query: 345 DLHHS-ESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQ-EDICSRLKDHV 402
D + L + + Q E+ + +T++ E++ + ++A +TA K + ED CS LK +
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDE-----EEINAELTAKKRKLEDECSELKKDI 960
Query: 403 KQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAM 462
LE ++ EK NK+ EE +G + +A+L + + Q+AH
Sbjct: 961 DDLELTLAKVEKEKHATENKVKNLTEE---------MAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 463 SANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKS 522
+ + +A ++++ +L ++ KL D EG L E + + +++ K
Sbjct: 1012 TLDDLQAEEDKVN------TLTKAKIKLEQQVDDLEGSLE---QEKKLRMDLERAKRKLE 1062
Query: 523 KVTSIVQE---EDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIE 579
+ QE + NE+ DE + K + E+ L ++ L QLQ +K+ +IE
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 580 DLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELK 639
+L + E+E + + K + Q SD+ R+ L++ ++ L+
Sbjct: 1123 ELEE--------EIEAERASRAKAEKQ------RSDLSRE-----------LEEISERLE 1157
Query: 640 ETEGKLRNTNQDLCNQMRQM-VQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHA 698
E G + Q N+ R+ Q D +EA + E T + + E L +
Sbjct: 1158 EAGG--ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAE--LGEQI 1213
Query: 699 LEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQ 758
Q++ + E+ +++ E+D L V V + + + LE L + KE++ Q
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQ 1273
Query: 759 EKIKEKLIQ----QLEK-EWQSKLDQTIKAMKKKTLDCGSQTDQV------TTSDVISKK 807
I + Q Q E E+ +LD+ + + + + T Q+ ++ +K
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKN 1333
Query: 808 EMAIMIEEQK--CTI---QQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNA 862
+A ++ + C + Q EQE ++ A+ K E+ + TK A+Q
Sbjct: 1334 ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEV----AQWRTKYETDAIQRT 1389
Query: 863 HQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNI- 921
EL E + + A++ + E+H +VN + + ++ + K++ ++E+E++ ++
Sbjct: 1390 E--------ELEEAKKKL-AQRLQAAEEHVEAVNAKCA-SLEKTKQRLQNEVEDLMLDVE 1439
Query: 922 ---LPGKELEEKIHSLQK---ELELKNEEVPVVIRAELAKARS---------EWNKEKQE 966
L++K + K E + K EE + A +ARS +E +
Sbjct: 1440 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLD 1499
Query: 967 EIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKE-DFMKQKTELLLQKETELQTCLDQSRR 1025
++ ++ +N ++ +Q + D +I E E + +K++ E Q++ ELQ L+++
Sbjct: 1500 QLETLKREN-KNLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEA 1555
Query: 1026 EWTMQEAK--RIQLEIYQYEEDI 1046
+E K RIQLE+ Q + ++
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEV 1578
Score = 94.0 bits (232), Expect = 1e-18
Identities = 192/894 (21%), Positives = 363/894 (40%), Gaps = 150/894 (16%)
Query: 230 ENSAENMQIIQLQVLNKAKERQLENLIEKLNES----ERQIRYLNHQLVIIKDEKDGLTL 285
E S E + +++ L +AK R+LE ++ ES E + + L+ +L + E L
Sbjct: 1041 EGSLEQEKKLRMD-LERAK-RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS 1098
Query: 286 SLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD 345
+ + Q L +++ +L+A+I+ LE +I+A + + + K+ LE + ++L +
Sbjct: 1099 KIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1158
Query: 346 LHHSES-------------------LQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVT 386
+ S L+ A QHE+ L KK+ + V L + +D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 387 ALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSL----------EESQKQCAH 436
++ E S +K + L N E + K + K+ R+L EE Q++ +
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSELKSKEEEQQRLIN 1277
Query: 437 LL--QSGSVQ-EVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIH 493
L Q G +Q E + QL + + + + +A +++ ELK ++ A H
Sbjct: 1278 DLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAH 1337
Query: 494 PSDS--------------EGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSK 539
S E E EL + + W+ T +Q + EE +K
Sbjct: 1338 ALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEE-AK 1396
Query: 540 DEFILKLKAEVQRLLGSNSMKRHL---VSQLQNDLKDCHKKIE---------DLHQVKKD 587
+ +L+A + + N+ L +LQN+++D +E D Q D
Sbjct: 1397 KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD 1456
Query: 588 -------EKSIEVETKTDTSEKPKNQLWPE----SSTSDVVRDDILLLKNEIQVLQQQNQ 636
+K E + + S+K L E + + D + LK E + LQQ+
Sbjct: 1457 KILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEIS 1516
Query: 637 ELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIR------ 690
+L E + +L ++++ V+ + Q A++ E + +H E +I+
Sbjct: 1517 DLTEQIAEGGKRIHEL-EKIKKQVEQEKCELQAALEEAEASL-EHEEGKILRIQLELNQV 1574
Query: 691 ESLLAKHALEKQQLFEAYERTHL-------------------------QLRSELDKLNKE 725
+S + + EK + + +R H+ ++ +L+++ +
Sbjct: 1575 KSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ 1634
Query: 726 VTAVQECYLEVCREKDNLELTLRKT---TEKEQQTQEKIKEK---------LIQQLEKEW 773
+ E R N + L+ T + ++QE +KE+ L+Q +E
Sbjct: 1635 LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEEL 1694
Query: 774 QSKLDQTIKAMK---KKTLDCGSQTDQV---TTSDVISKKEMAIMIEEQKCTIQQNLEQE 827
++ L+QT ++ K ++ LD + + TS + +KK++ I + + ++ L++
Sbjct: 1695 RATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEA 1754
Query: 828 KDIAIK-------GAMKKLEIELE---LKHCENITKQVEIAVQNAHQRWLGELPELA--- 874
++ K AM E++ E H E + K +E V++ R L E +LA
Sbjct: 1755 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLR-LDEAEQLALKG 1813
Query: 875 EYQALVKAEQKKWEEQHEV-SVNKRISFAVSEAK--EKWKSEL----ENMRKNILPGKEL 927
+ + K E + E + EV S KR + AV + E+ EL E RKNIL ++L
Sbjct: 1814 GKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 928 EEKIHSLQKELELKNEEVPVVIRAELAKARS-EWNKEKQEEIHRIQEQNEQDYR 980
+K+ + K + + EE LAK R + E+ EE I E R
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Score = 89.4 bits (220), Expect = 3e-17
Identities = 181/938 (19%), Positives = 400/938 (42%), Gaps = 128/938 (13%)
Query: 188 EPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENM----QIIQLQV 243
E + K+ + +S A+ + +T LQ Q E A+ Q+I+ ++
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 244 LNKAKERQLENLIEKLNESERQI----RYLNHQLVIIKDEKDGLTLSLRESQK------- 292
+AK +++ E E ++ R L + +K + D L L+L + +K
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 293 LFQNGKEREIQLEAQIKALETQIQALKVNEEQMIK-------KSRTTEMALESLKQQLVD 345
+N E L+ I L + +AL+ +Q + K T A L+QQ+ D
Sbjct: 980 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD 1039
Query: 346 LHHS----ESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDH 401
L S + L+ E+ + + G K +E ++ ++ LK++E S L+
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSK 1099
Query: 402 VKQLERNQEAIKLEKTEIINKLTRSLEESQKQC---------AHLLQSGSVQEVAQLQFQ 452
++ +++A+ ++ + I +L +EE +++ A +S +E+ ++ +
Sbjct: 1100 IE----DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155
Query: 453 LQQAQKAHAMSANMNKALQEELTELK---DEISLYE--SAAKLGIHPSDSEGELNIELTE 507
L++A A + MNK + E +++ +E +L +AA L +DS EL ++
Sbjct: 1156 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID- 1214
Query: 508 SYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQL 567
+++V K K S ++ E ++ S E + K K ++++ + +S+L
Sbjct: 1215 -----NLQRVKQKLEKEKSEMKME-IDDLASNVETVSKAKGNLEKMCRT---LEDQLSEL 1265
Query: 568 QNDLKDCHKKIEDLH------QVKKDEKSIEVETK--------------TDTSEKPKNQL 607
++ ++ + I DL Q + E S +++ K T E+ K QL
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 608 WPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHD- 666
E + + + +++ +L++Q +E +E++ +L+ ++ Q ++ D
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 667 --KQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNK 724
+ E ++ ++ Q +A + + E++ AK A + E+T +L++E++ L
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHV-EAVNAKCA--------SLEKTKQRLQNEVEDLML 1436
Query: 725 EVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKL---------IQQLEKEWQS 775
+V + +++ N + L + +K ++T +++ + +++ ++
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 776 KLDQ--TIKAMKKK-TLDCGSQTDQVTTSD--VISKKEMAIMIEEQKCTIQQNLEQEKDI 830
LDQ T+K K + T+Q+ + +++ +E++KC +Q LE+ +
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556
Query: 831 AIKGAMKKLEIELELKHCEN------ITKQVEI-AVQNAHQRWLGELPELAEYQALVKAE 883
K L I+LEL ++ K EI ++ H R + + + + + +
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Query: 884 QKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIH---SLQKELEL 940
+ +++ E +N+ + ++ A L N R G + +IH +L+ + +L
Sbjct: 1617 AIRLKKKMEGDLNE-MEIQLNHANRMAAEALRNYRNT--QGILKDTQIHLDDALRSQEDL 1673
Query: 941 KNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKED 1000
K + V RA L +A E + E+ R ++ EQ + LD A+ +
Sbjct: 1674 KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ---ELLD----------ASERVQ 1720
Query: 1001 FMKQKTELLLQKETELQTCLDQSRREW--TMQEAKRIQ 1036
+ + L+ + +L+T + Q + E +QEA+ +
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758
Score = 76.6 bits (187), Expect = 2e-13
Identities = 146/725 (20%), Positives = 300/725 (41%), Gaps = 143/725 (19%)
Query: 617 VRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCER 676
++++ +K+E+ + + +EL+E L DL Q++ + +A +RC+
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL----ADAEERCD- 912
Query: 677 TYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEV 736
+ +KT+I+ K E+ E E + +L ++ KL E + E+
Sbjct: 913 ------QLIKTKIQLEAKIKEVTERA---EDEEEINAELTAKKRKLEDECS-------EL 956
Query: 737 CREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAM--KKKTLDCGSQ 794
++ D+LELTL K +++ T+ K+K E + LD+TI + +KK L +
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLT------EEMAGLDETIAKLTKEKKALQ---E 1007
Query: 795 TDQVTTSDVISKKEMA-------IMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKH 847
Q T D+ ++++ I +E+Q ++ +LEQEK + + K ++E +LK
Sbjct: 1008 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 848 CENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAK 907
+ +E Q ++ + E++ Q+ ++ EQ + + K+I
Sbjct: 1068 AQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQAL-----GIQLQKKI-------- 1114
Query: 908 EKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEE 967
KEL+ +I L++E+E + RA+ K RS+ ++E +E
Sbjct: 1115 -----------------KELQARIEELEEEIEAERAS-----RAKAEKQRSDLSRELEEI 1152
Query: 968 IHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREW 1027
R++E Q NK E +F K + +L +E LQ
Sbjct: 1153 SERLEEAGGATSAQI---EMNKKREA------EFQKMRRDL---EEATLQ---------- 1190
Query: 1028 TMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYF 1087
EA L + D + LG + + Q+ + +K+ E+ +V+
Sbjct: 1191 --HEATAATLR--KKHADSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDDLASNVETV 1244
Query: 1088 EKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLA 1147
K KG ++K + L E E +++ + ++ +A +G Q + G +
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRL--INDLTAQRGRLQTESGEFSRQ------ 1296
Query: 1148 LQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGAL 1207
L EA + ++ + ++ ++K +LEE + ++ A A++++
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALAHALQSS--------- 1342
Query: 1208 EELRGQYIKAVKKIKCDMLR-YIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQI 1266
+ CD+LR +E +E AE+ +A + + E A+ KY +Q+
Sbjct: 1343 ------------RHDCDLLREQYEEEQESKAELQRA-LSKANTEVAQWRTKYETDAIQRT 1389
Query: 1267 LQ-DDGKEGAEKKIMNAASKL----ATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVK 1321
+ ++ K+ +++ A + A A L +T +++ + + T+ A+
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449
Query: 1322 KSKRN 1326
K +RN
Sbjct: 1450 KKQRN 1454
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 105 bits (263), Expect = 3e-22
Identities = 239/1188 (20%), Positives = 468/1188 (39%), Gaps = 178/1188 (14%)
Query: 210 QEITGS-DTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRY 268
Q++TG DT G G ++ ++ +++Q KA+E +L +E L + ++R
Sbjct: 438 QKLTGERDTLAGQTVDLQGEVDSLSKERELLQ-----KARE-ELRQQLEVLEQEAWRLRR 491
Query: 269 LNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKK 328
+N +L + D G +E L +ER L+ + L+ + + + +
Sbjct: 492 VNVELQLQGDSAQGQKEEQQEELHLAVRERER----------LQEMLMGLEAKQSESLSE 541
Query: 329 SRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTAL 388
T ALES H E +EQ E V + E+ + L + + T +
Sbjct: 542 LITLREALES--------SHLEGELLRQEQTE--VTAALARAEQSIAELSSSENTLKTEV 591
Query: 389 KEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQ 448
+ L+ +L EA+ L+K + +L + EE+Q C+ + + Q
Sbjct: 592 AD-------LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRM--EAAEQARNA 642
Query: 449 LQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTES 508
LQ L +A+K +AL E+ T L+ ++ E A ++ + +L ++ E
Sbjct: 643 LQVDLAEAEKRR-------EALWEKNTHLEAQLQKAEEAG------AELQADLR-DIQEE 688
Query: 509 YVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFIL-KLKAEVQRLLGSNSMKRHLVSQL 567
++ K + + + Q E ++E + E +L + E + L+ + + +
Sbjct: 689 KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV 748
Query: 568 QNDLKDCHKKIEDLHQVKK--DEKSIEVETKTDTSEKPKNQLWPESST----SDVVRDDI 621
+ D +D ++++ L K+ + E + + E K QL + T +V++ ++
Sbjct: 749 ERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808
Query: 622 LLLKNEIQVLQQQNQELK----------ETEGKLRNTNQDLCNQ--MRQMVQDFDHDKQ- 668
LK E+ + Q ++ + E EGK Q ++ + Q+ + ++ ++
Sbjct: 809 RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSW 868
Query: 669 ------EAVDRCERTYQQHHEAMKTQIRE--SLLAKHALEKQQLFEAYERTHLQLRSELD 720
+A++ ER + +K Q E ++ A+ E+ Q A + L+ E
Sbjct: 869 HQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERV 928
Query: 721 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQT-----------QEKIKEKLIQQL 769
L + + Q+ + ++ + L ++ KEQ+T Q ++KE Q
Sbjct: 929 SLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHR 988
Query: 770 E-----KEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQK--CTIQQ 822
+ +E S L Q ++K+ D SQ S + ++E+ + E + IQ+
Sbjct: 989 DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQK 1048
Query: 823 NLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKA 882
LE+EK M+K + L L+ ++I +Q A++ Q GE EL+ L++
Sbjct: 1049 ELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQ 1108
Query: 883 EQK---------------KWEEQHEVSVNKRISFAVSEAK--------EKWKSELENMRK 919
E K + E H R S EAK +S+LE +
Sbjct: 1109 EVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA 1168
Query: 920 NILPGK--ELEEKIHSLQKELELKNEEVPVVIRAELA----KARSEWNKEKQEE------ 967
PG + + ++ SL L+ V R EL+ A S W E +
Sbjct: 1169 EQQPGNQAQAQAQLASLYSALQQALGSV-CESRPELSGGGDSAPSVWGLEPDQNGARSLF 1227
Query: 968 -----------------IHRIQEQ--NEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTEL 1008
+H++ + Q R L D K+ E L + + + TEL
Sbjct: 1228 KRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTEL 1287
Query: 1009 LLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYE-EDILTVLGVLLSDTQKEHISDSED 1067
+LQ L Q++ E + E K+ LE E + + L L + + + +
Sbjct: 1288 -----QDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE 1342
Query: 1068 KQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRN-MAELSKDSA 1126
++LL+ + + ++ Q + L + A K +N E ++ A
Sbjct: 1343 RELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERA 1402
Query: 1127 SQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTP 1186
QG+ A G Q T+ AE EE ++ +++EL+
Sbjct: 1403 QALQEQGELKVAQGKALQENLALLTQTLAERE--------EEVETLRGQIQELE-----K 1449
Query: 1187 PRSLSAGAIENACLPCSGGALE-ELRGQYIKAVKKIKCDMLRYIQESKERAAEM-VKAEV 1244
R + A+E L E +L+ + I+ ++K + + +ER ++ V+ E
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ 1509
Query: 1245 LRERQ---ETARKMRKYYLICLQQILQDDGKEGAEKKIMNAASKLATM 1289
+RE + ET R + ++ L+ L++ +D E ++ + +L T+
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEK--KDQMIESQRGQVQDLKKQLVTL 1555
Score = 103 bits (257), Expect = 1e-21
Identities = 236/1139 (20%), Positives = 460/1139 (40%), Gaps = 151/1139 (13%)
Query: 230 ENSAENMQIIQL-QVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLR 288
+ +A ++ QL + K + + L + L ER+ L +L + E + + R
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ-R 905
Query: 289 ESQKLFQNGKEREIQLEAQ---IKALETQIQALK--VNEEQMIKKSRTTEMALESLKQQ- 342
E ++ ++QLE + + LET +Q K + Q +++ R +M ++ LK+Q
Sbjct: 906 EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ-DMKVQKLKEQE 964
Query: 343 -----LVDLHHSE-SLQRAREQHESIVMGLTKKYE---EQVLSLQKNLDATVTALKEQED 393
L ++ L+ A QH + L ++ + + LQK ++ + L Q+D
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Query: 394 ICSRLKDHVKQ-LERNQEAIKLEKTEIINK--LTRSLEESQKQCAHLLQSGSV--QEVAQ 448
++ V++ L QE +++K K LT SL E +++ L ++ S+ QE++
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
Query: 449 LQFQLQQAQ-KAHAMSANMNKALQE----ELTELKDEISLYESAAKLGIHPSDSEGELNI 503
L+ +Q+AQ + +SA M QE E L E L E H ++ + ++
Sbjct: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELE--ASHITEQQLRASL 1142
Query: 504 ELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHL 563
E+ ++ +S++ ++ E+ P + + L + +Q+ LGS R
Sbjct: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPE 1202
Query: 564 VSQLQNDLKDCHKKIEDLHQVKKDEK------SIEVETKTDTSEKPKNQLWPESSTSDVV 617
+S + D + + K ++ E K LW T DV+
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262
Query: 618 RDDILLLK--------------NEIQVLQQ---QNQELK-ETEGKLRNTNQDLCN----- 654
RD + L+ E+Q LQ+ QNQE K + EGK + +L
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322
Query: 655 ----------QMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQL 704
++++M + + +A +H +A + R A LE+
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL- 1381
Query: 705 FEAYERTHLQLRS-ELDKLNKEVTAVQE-CYLEVCREK---DNLELTLRKTTEKEQQTQE 759
R+ L+L++ E++ + A+QE L+V + K +NL L + E+E++ +
Sbjct: 1382 --RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET 1439
Query: 760 KIKEKLIQQLEKE---WQSKLDQTIKAMKKKTLDCGSQTDQVTTSD----VISKKEMAIM 812
+ IQ+LEK+ ++ L+ +KK+ + Q +Q+ + V+ MA+
Sbjct: 1440 LRGQ--IQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497
Query: 813 IEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPE 872
EQK T+Q+ EQ +++ ++ +E +L E + +E QR G++ +
Sbjct: 1498 EREQKLTVQR--EQIRELEKDRETQRNVLEHQLLELEKKDQMIE------SQR--GQVQD 1547
Query: 873 LAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPG-----KEL 927
L + ++ + EE H E ++K ELE R+ +L
Sbjct: 1548 LKKQLVTLECLALELEENHH----------KMECQQKLIKELEGQRETQRVALTHLTLDL 1597
Query: 928 EEKIHSLQ-KELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNE---QDYRQFL 983
EE+ LQ + ++ + E + A + R + K ++E+I +Q Q E QD +
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLER-- 1655
Query: 984 DDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWT-----MQEAKRIQLE 1038
D + + ED ++T++L + +++ L + RE T MQE
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKG 1715
Query: 1039 IYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAF 1098
+ + L + ++L D +KE + + + + E+ + Q ++L+G +K
Sbjct: 1716 PSKAQRGSLEHMKLILRDKEKE--VECQQEHIHELQE------LKDQLEQQLQGLHRKVG 1767
Query: 1099 QDTLPL-------------LVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQP 1145
+ +L L L E + K + D A + Q D A Q
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 1146 LALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGG 1205
A E E+ + + L + + +K + ELQ + R A+E +
Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887
Query: 1206 ALEELRGQYIKAVKKIKCDMLRYIQESKERAAE--------MVKAEVLRERQETARKMR 1256
L +LR + + K + + ++++E E + VL+ER + +R
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR 1946
Score = 93.2 bits (230), Expect = 2e-18
Identities = 192/868 (22%), Positives = 360/868 (41%), Gaps = 138/868 (15%)
Query: 295 QNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHS----- 349
Q +ER EA+ + T++Q L+ Q ++ E SL+ +L++LH +
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326
Query: 350 -----ESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQ 404
LQR Q E ++ K E + + ++L A V + Q L++ ++
Sbjct: 1327 SRLRRAELQRMEAQGERELLQAAK---ENLTAQVEHLQAAVVEARAQASAAGILEEDLR- 1382
Query: 405 LERNQEAIKLEKTEIINKLTRSLEES-----------QKQCAHLLQ--SGSVQEVAQLQF 451
R+ +K E+ E + ++L+E Q+ A L Q + +EV L+
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 452 QLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAK-----------LGIHPSDSEGE 500
Q+Q+ +K M + L +L + E+ L + + L + + E +
Sbjct: 1443 QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK 1502
Query: 501 LNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMK 560
L ++ + I+++ K + V E E KD+ I + +VQ L
Sbjct: 1503 LTVQREQ------IRELE-KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555
Query: 561 RHLVSQLQND--LKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVR 618
L +L+ + +C +K+ + +++ + + + T E+ +L +SS +
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615
Query: 619 DDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCER-- 676
+L E LQ+++QE+K R ++L Q + QD + QE + + ER
Sbjct: 1616 SHSTVLARE---LQERDQEVKSQ----REQIEELQRQKEHLTQDLERRDQELMLQKERIQ 1668
Query: 677 -----------TYQQHHEAMKTQIRE---------SLLAKHALEKQQLFEAYERTHLQLR 716
++ E +K +RE L+ + A E + +A + ++
Sbjct: 1669 VLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMK 1728
Query: 717 SELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKE---W 773
L KEV QE E+ KD LE L+ K +T L+ Q E+E
Sbjct: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGET-----SLLLSQREQEIVVL 1783
Query: 774 QSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEM-AIMIEEQKCTIQQNLEQEKDIAI 832
Q +L + + + K SQ D+ + +E+ A+ E+Q+ Q+ +EK A+
Sbjct: 1784 QQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADAL 1843
Query: 833 KGAMKKLEIELELKHCE-------NITKQVEIAVQ----NAHQRWLGEL-PELAEYQALV 880
+GA+++ + L+ +H E + E+AV+ A + LG+L E E + +
Sbjct: 1844 QGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL 1903
Query: 881 KAEQKKWEEQ---HEVSVNK-RISFAVSEAKEKWK-SELENMRKNILPGKELEE----KI 931
A Q++ EQ HEV + S+ ++A K + ELE +R + EE +
Sbjct: 1904 LALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA 1963
Query: 932 HSLQKEL-----ELKNEEVPVVIRAELAKA-------------RSEWNKEKQEEIHRIQE 973
+LQ+ L L+ +E ++ +AEL+++ + + + EE RIQE
Sbjct: 1964 EALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE 2023
Query: 974 QNEQDYRQFLDDHRNKINEVLAAAKEDFM-KQKTELLLQKE---------TELQTCLDQS 1023
QD + ++ + LA E+ +Q+ E LL+K + + L Q
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQE 2083
Query: 1024 RREWTM----QEAKRIQLEIYQYEEDIL 1047
R E + Q + +QL + Q E++IL
Sbjct: 2084 REEEEIRGLHQSVRELQLTLAQKEQEIL 2111
Score = 91.3 bits (225), Expect = 7e-18
Identities = 168/863 (19%), Positives = 331/863 (38%), Gaps = 94/863 (10%)
Query: 231 NSAENMQIIQLQVLNKAKERQLENLI-------EKLNESERQIRYLNHQLVIIKDEKDGL 283
N ++Q Q+Q L K + LE+L +KL QIR L ++ +
Sbjct: 1469 NQEVDLQQEQIQELEKCRS-VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ 1527
Query: 284 TLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQL 343
L L + ++ ++ + + L+ Q+ LE L+ N +M + + + + Q
Sbjct: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
Query: 344 VDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNL---DATVTALKEQEDICSRLKD 400
V L H R Q E L + L D V + +EQ + R K+
Sbjct: 1588 VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE 1647
Query: 401 HVKQ-LERNQEAIKLEKTEI------INKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQL 453
H+ Q LER + + L+K I + T+ LEE +Q L+ + Q Q
Sbjct: 1648 HLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQ 1707
Query: 454 QQAQKAHAMSANMNKALQ--------------------EELTELKDEISLYESAAKLGIH 493
++A++ S +L+ EL ELKD++ G+H
Sbjct: 1708 ERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQL----EQQLQGLH 1763
Query: 494 PSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEEL--------SKDEFILK 545
GE ++ L++ ++ + + ++++ ++E+ +L +D+ +
Sbjct: 1764 --RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821
Query: 546 LKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKN 605
L+ E Q+ G + LQ L+ H +++ H +D K + + + + +
Sbjct: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
Query: 606 QLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDH 665
E D +R + + + LQQQ E + QD Q + ++++ D
Sbjct: 1882 VQALEEVLGD-LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQ 1940
Query: 666 DKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKE 725
+ + R E +H E E+L + AL K + HL ++EL + +
Sbjct: 1941 ELEAL--RAESQSSRHQEEAARARAEAL--QEALGKAHAALQGKEQHLLEQAELSRSLEA 1996
Query: 726 VTAVQECYLEVCR-EKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAM 784
TA + L+ C+ LE LR I+E IQ + +Q + Q +A+
Sbjct: 1997 STATLQASLDACQAHSRQLEEALR------------IQEGEIQDQDLRYQEDVQQLQQAL 2044
Query: 785 KKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELE 844
++ + Q ++ + + +K +A ++E +QNL QE++ E E
Sbjct: 2045 AQRDEELRHQQER----EQLLEKSLAQRVQENMIQEKQNLGQERE------------EEE 2088
Query: 845 LKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVS 904
++ +++++ + Q E+ EL E Q + + H+ S + S +
Sbjct: 2089 IRGLHQSVRELQLTLAQKEQ----EILELRETQQ--RNNLEALPHSHKTSPMEEQSLKLD 2142
Query: 905 EAKEKWKSELENMRKNI--LPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNK 962
+ + + ELE ++ + +E+E + + L L + V E+A
Sbjct: 2143 SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVL 2202
Query: 963 EKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQ 1022
E+ E R+Q++ E R + + A +Q +L E + D
Sbjct: 2203 ERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDG 2262
Query: 1023 SRREWTMQEAKRIQLEIYQYEED 1045
++ Q + +Q + + E D
Sbjct: 2263 MEKQSWRQRLEHLQQAVARLEID 2285
Score = 80.5 bits (197), Expect = 1e-14
Identities = 169/846 (19%), Positives = 350/846 (41%), Gaps = 132/846 (15%)
Query: 251 QLENLIEKLNESERQIRYLNHQLVIIKDEKD-----------GLTLSLRESQKLFQNGKE 299
QL L+ K E E++ + +L+ +K + D L+ L +SQK
Sbjct: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQK------- 297
Query: 300 REIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQH 359
+ E IKAL ++ L+ N +++ +H
Sbjct: 298 QNEDYEKMIKALRETVEILETNHTELM-------------------------------EH 326
Query: 360 ESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEI 419
E+ L++ +E+ LSLQ+ + + E+ D ++ H LE + +
Sbjct: 327 EA---SLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQD 383
Query: 420 INK---LTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTE 476
+K L RS+ ++Q L+ Q++A Q + Q+ H KAL++ L +
Sbjct: 384 ADKALTLVRSVLTRRRQAVQDLR----QQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQK 439
Query: 477 L---KDEISLYESAAKLGIHPSDSEGELNIELTESYVDL--GIKKVNWKKSKVTSIVQEE 531
L +D ++ + + E EL + E +++ W+ +V +Q +
Sbjct: 440 LTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQ 499
Query: 532 DPNEELSKDEFILKLKAEV-------QRLLGSNSMKRHLVSQ---LQNDLKDCHKKIEDL 581
+ + K+E +L V + L+G + + +S+ L+ L+ H + E L
Sbjct: 500 GDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
Query: 582 HQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDI-LLLKNEIQVLQQ--QNQEL 638
Q + + + + +E ++ ++ +D+ + L NE L + NQ+L
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL 619
Query: 639 KETEGKLRNTNQDLCNQM---RQMVQDFDHDKQEAVDRCERTYQQH-HEAMKTQIRESLL 694
+ L NQ +C++M Q D EA R E ++++ H + Q E
Sbjct: 620 LQ----LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAG 675
Query: 695 AKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKE 754
A+ + + + E E +L + T +++ + E R++ E+ R EKE
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE---EVLARAVQEKE 732
Query: 755 QQTQEKIK-EKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMI 813
+EK E +Q +E++ Q +Q L S ++ S + ++ +I
Sbjct: 733 ALVREKAALEVRLQAVERDRQDLAEQ---------LQGLSSAKELLESSLFEAQQQNSVI 783
Query: 814 EEQKCTIQ---QNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGEL 870
E K ++ Q + Q K++ I+G ++ L++EL+ + + ++ A Q A G+
Sbjct: 784 EVTKGQLEVQIQTVTQAKEV-IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 871 ---PELAEYQALVKAEQKKWEEQ---HEVSVNKRISFAVSEAKEKWKSELENMRK----- 919
+ A ++ V ++KWE++ H+ + K + E+ E+ K ELE K
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL-----ESLEREKMELEMRLKEQQTE 897
Query: 920 -NILPGKELEEKIHS----LQKELELKNEEVPVV-----IRAELAKARSEWNKEKQE-EI 968
+ + EE+ + Q +LE + E V ++ + ELA A + + +Q+ ++
Sbjct: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957
Query: 969 HRIQEQNEQDYRQF-LDDHRNKINEVLAAAKEDF--MKQKTELLLQKETELQTCLDQSRR 1025
+++EQ Q L + + ++ E ++D +++++ LLQ + +LQ ++ +
Sbjct: 958 QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
Query: 1026 EWTMQE 1031
+ Q+
Sbjct: 1018 QLVAQD 1023
Score = 64.3 bits (155), Expect = 9e-10
Identities = 135/660 (20%), Positives = 263/660 (39%), Gaps = 79/660 (11%)
Query: 230 ENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDE----KDGLTL 285
E + I +LQ L E+QL+ L K+ E+ + ++V+++ + ++ L
Sbjct: 1737 EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796
Query: 286 SLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD 345
+ Q + Q + +++AL+ + Q + EE++ +K+ + ALE L +
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 346 LH-----HSESLQRAREQ----------HESIVMGLTKKYEEQVLSLQKNLDATVTALKE 390
H H E +R E+ E ++ L + EQ +L +E
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 391 QEDICSRLKDHVKQL-----ERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQE 445
E L+D Q ER+QE LE ++ +R EE+ + A LQ +
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQE---LEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 446 VAQLQFQ----LQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGEL 501
A LQ + L+QA+ + ++ A+ LQ L + E A ++ EGE+
Sbjct: 1974 HAALQGKEQHLLEQAELSRSLEAS-TATLQASLDACQAHSRQLEEALRI------QEGEI 2026
Query: 502 NIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKR 561
D ++ + ++ Q ++ + E +L+ K+ QR+ + ++
Sbjct: 2027 Q--------DQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLE-KSLAQRVQENMIQEK 2077
Query: 562 HLVSQ--LQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRD 619
+ Q + +++ H+ + +L Q+ +K E+ +T ++ + P S + + +
Sbjct: 2078 QNLGQEREEEEIRGLHQSVREL-QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
Query: 620 DIL-------LLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVD 672
L L+ E++ LQ ++ + E + R QDL + Q ++ A+
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196
Query: 673 RCERTYQQHHEAMKTQIRESLLAKHALEKQQLFE--AYERTHLQLRSELDKLNKEVTAVQ 730
++ E + Q E L + ALEK++L A L R E EV+ V
Sbjct: 2197 LQASVLERDSEQQRLQ-DELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGV- 2254
Query: 731 ECYLEVCREKDNLE-LTLRKTTEKEQQ--TQEKIKEKLIQQLEKEWQSKLDQTIKAMKK- 786
E D +E + R+ E QQ + +I +Q+ + +S L+Q + +K
Sbjct: 2255 ----EAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310
Query: 787 -----KTLDCGS-QTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 840
+ GS + + T S + + KC E +K++ + A LE
Sbjct: 2311 KREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCV----AELQKEVVLLQAQLTLE 2366
Score = 51.6 bits (122), Expect = 6e-06
Identities = 155/749 (20%), Positives = 302/749 (40%), Gaps = 127/749 (16%)
Query: 592 EVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKE--TEGKLRNTN 649
E+E + + + P Q W ++ D LL++ E + QQ+ + L E T+ +L
Sbjct: 72 ELEKRLEATGGPIPQRWENVEEPNL---DELLVRLEEE--QQRCESLAEVNTQLRLHMEK 126
Query: 650 QDLCNQ-MRQMVQDFDHDKQEAVD---RCERTYQQHHEAMKTQIRESLLAKHALEKQQLF 705
D+ N+ +R+ V+ D A D R E +Q E K ++ +L ++ +
Sbjct: 127 ADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVV- 185
Query: 706 EAYERTHLQLRSELDK----LNKEVTAVQECYLEVC--------------------REKD 741
+ R L+++S D+ L E + L C RE
Sbjct: 186 -TFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPA 244
Query: 742 NLELTLRKTTEKEQQTQEKIKEKLIQ-----QLEK--------EWQSKLDQTIKAMK--K 786
L L L KT E E++ E+ +E LIQ LEK E + L Q+ K + +
Sbjct: 245 QLLLLLAKTQELEKEAHERSQE-LIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYE 303
Query: 787 KTLDCGSQTDQV--TTSDVISKKEMAIM--IEEQKCTIQQNLE-------QEKDIAIKGA 835
K + +T ++ T + + E ++ +E+K ++QQ ++ +E D +G+
Sbjct: 304 KMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS 363
Query: 836 MKKLEIELE---------------LKHCENITKQVEIAVQNAHQRWLGELPELAEYQALV 880
+ +EL+ L ++ + AVQ+ Q+ G E L+
Sbjct: 364 GHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG----CQEAVNLL 419
Query: 881 KAEQKKWEEQHEVSVNKRISFAVSEAKE------KWKSELENMRKNI----LPGKELEEK 930
+ + +WEE+ + ++ +R+ E + E++++ K +EL ++
Sbjct: 420 QQQHDQWEEEGK-ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ 478
Query: 931 IHSLQKEL-ELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNE--QDYRQFLDDHR 987
+ L++E L+ V + ++ + A+ + E E+QEE+H + E Q+ L+ +
Sbjct: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKE---EQQEELHLAVRERERLQEMLMGLEAKQ 535
Query: 988 NKINEVLAAAKEDFMKQ--KTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEED 1045
++ L +E + ELL Q++TE+ L +R E ++ E + + D
Sbjct: 536 SESLSELITLREALESSHLEGELLRQEQTEVTAAL--ARAEQSIAELSSSENTLKTEVAD 593
Query: 1046 ILTVLGVLLSDTQKEHISDSE--DKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLP 1103
L V LS + D ++QLL++ S ++ E+ + +Q +
Sbjct: 594 -LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEA-- 650
Query: 1104 LLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVE 1163
+ + W+K E A + AG Q L+ + E EE K +
Sbjct: 651 --EKRREALWEKNTHLEAQLQKAEE----------AGAELQA-DLRDIQEEKEEIQKKLS 697
Query: 1164 ELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKC 1223
E + +LE+L K L+ E L ALE ++AV++ +
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALE----VRLQAVERDRQ 753
Query: 1224 DMLRYIQESKERAAEMVKAEVLRERQETA 1252
D+ +Q A E++++ + +Q+ +
Sbjct: 754 DLAEQLQ-GLSSAKELLESSLFEAQQQNS 781
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 105 bits (261), Expect = 5e-22
Identities = 227/1072 (21%), Positives = 439/1072 (40%), Gaps = 161/1072 (15%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER-------E 301
+ + + ++L +SE + + L +LV + EK+ L L ++ + + +ER +
Sbjct: 854 KEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAK 913
Query: 302 IQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHS-ESLQRAREQHE 360
QLEA+IK + + + + ++ K R E LK+ + DL + +++ + E
Sbjct: 914 FQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 973
Query: 361 SIVMGLTKK---YEEQVLSLQK------------------------NLDATVTALKEQ-E 392
+ V LT++ +E + L + +L+ T + L++Q E
Sbjct: 974 NKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE 1033
Query: 393 DICSRLKDHVK---QLERNQEAIKLE-KTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQ 448
D+ S L+ K LERN+ KLE ++ + LE ++Q L+ E Q
Sbjct: 1034 DLESSLEQEKKLRVDLERNKR--KLEGDLKLAQESILDLENDKQQLDERLKKKDF-EYCQ 1090
Query: 449 LQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESA-AKLGIHPSDSEGELNIELTE 507
LQ +++ Q K LQ + EL++EI + AK SD EL EL+E
Sbjct: 1091 LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE-ELSE 1149
Query: 508 SYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQR-LLGSNSMKRHLVSQ 566
+ G VTS E + E LKL+ +++ L +M L +
Sbjct: 1150 RLEEAG---------GVTSTQIELNKKREAE----FLKLRRDLEEATLQHEAMVAALRKK 1196
Query: 567 LQNDLKDCHKKIEDLHQVK------KDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDD 620
+ + + ++I++L +VK K E +E++ + + E + D
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ 1256
Query: 621 ILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQ 680
+ + + + +Q+ EL + +L+ +L Q+ + + R ++ + Q
Sbjct: 1257 LSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE-----KESIVSQLSRSKQAFTQ 1311
Query: 681 HHEAMKTQIRESLLAK----HALEKQQ-----LFEAYERTH---LQLRSELDKLNKEVTA 728
E +K Q+ E AK HAL+ + L E YE +L+ L K N EV
Sbjct: 1312 QTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1371
Query: 729 VQECY-LEVCREKDNLELTLRKTTEKEQQTQEKIK---------EKLIQQLEKEWQSKLD 778
+ Y + + + LE +K ++ Q ++E+++ EK Q+L+ E + D
Sbjct: 1372 WRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE---D 1428
Query: 779 QTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIA-----IK 833
+ + +L Q V++ E EE + ++ +L++ + ++ +K
Sbjct: 1429 LMVDVERANSLAAALDKKQRNFDKVLA--EWKTKCEESQAELEASLKESRSLSTELFKLK 1486
Query: 834 GAMKKLEIELELKHCENITKQVEIAVQN----AHQRWLGELPELAEYQALVKAE-QKKWE 888
A ++ +LE EN + EIA + + + EL + + L KA+ Q E
Sbjct: 1487 NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE 1546
Query: 889 E-----QHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNE 943
E +HE + RI +++ KSE++ RK +E+E+ + Q+ +E
Sbjct: 1547 EAEAALEHEEAKILRIQLELTQV----KSEID--RKIAEKDEEIEQLKRNYQRTVETMQS 1600
Query: 944 EVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMK 1003
+ +R+ R + K+ + +++ I+ Q RQ + ++ + V K+ +
Sbjct: 1601 ALDAEVRSRNEAIRLK--KKMEGDLNEIEIQLSHANRQAAETLKH-LRSVQGQLKDTQLH 1657
Query: 1004 QKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHIS 1063
L Q++ + Q + + R E + ++ + Q E ++E +
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTER--------ARKLAEQELLD 1709
Query: 1064 DSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSK 1123
+E QLL +T S+ + +K K D + L E D RN E +K
Sbjct: 1710 SNERVQLLHTQNT------SLIHTKK------KLETDLMQLQSEVEDASRDARNAEEKAK 1757
Query: 1124 DSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLC 1183
+ + AA + Q T A E K +E+ ++ D++++L+E + L
Sbjct: 1758 KAITD---------AAMMAEELKKEQDTSAHLERMKKNLEQTVK---DLQHRLDEAEQL- 1804
Query: 1184 KTPPRSLSAGAIENACLPCSGGALE-ELRGQYIKAVKKIKCDMLRYIQESKE 1234
+L G + L LE EL G+ K + +K + +Y + KE
Sbjct: 1805 -----ALKGGKKQIQKLETRIRELEFELEGEQKKNTESVK-GLRKYERRVKE 1850
Score = 97.1 bits (240), Expect = 1e-19
Identities = 175/875 (20%), Positives = 371/875 (42%), Gaps = 119/875 (13%)
Query: 240 QLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKD----GLTLSLRESQKLFQ 295
+L+V + +R+LE ++ ES + QL +KD L + + Q L
Sbjct: 1044 KLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGL 1103
Query: 296 NGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD---------- 345
+++ +L+A+I+ LE +I+A + + K+ LE L ++L +
Sbjct: 1104 QFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 1163
Query: 346 ---------LHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICS 396
L L+ A QHE++V L KK+ + V L + +D ++ E S
Sbjct: 1164 LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1223
Query: 397 RLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQA 456
K + L + E++ K + K+ R+LE+ ++++ + + ++
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKAN-LEKICRTLED---------------QLSEARGKNEEI 1267
Query: 457 QKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKK 516
Q++ + LQ E EL ++ ES + + EL +++
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ-----LEE 1322
Query: 517 VNWKKSKVTSIVQEEDPNEELSKDEFILKL--KAEVQRLLGSNSMKRHLVSQLQNDLK-D 573
N K+ + +Q + +L ++++ + KAE+QR L + + V+Q + + D
Sbjct: 1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE---VAQWRTKYETD 1379
Query: 574 CHKKIEDLHQVKK--------DEKSIE-VETKTDTSEKPKNQLW--PESSTSDVVRDDIL 622
++ E+L + KK E+ +E V K + EK K +L E DV R + L
Sbjct: 1380 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439
Query: 623 LL------KNEIQVLQQQNQELKETEGKLR---NTNQDLCNQMRQMVQDFDH--DKQEAV 671
+N +VL + + +E++ +L ++ L ++ ++ ++ D+ E V
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV 1499
Query: 672 DRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDK--LNKEVTAV 729
R + +Q + QI E+ H LEK + E+ +QL E + L E +
Sbjct: 1500 KRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 1559
Query: 730 QECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTL 789
LE+ + K ++ RK EK+++ ++ ++ Q+ + QS LD +++ +
Sbjct: 1560 LRIQLELTQVKSEID---RKIAEKDEEIEQ--LKRNYQRTVETMQSALDAEVRSRNE--- 1611
Query: 790 DCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELE--LKH 847
+ + D+ E+ I + + L+ + +++G +K ++ L+ L+
Sbjct: 1612 --AIRLKKKMEGDL---NEIEIQLSHANRQAAETLKHLR--SVQGQLKDTQLHLDDALRG 1664
Query: 848 CENITKQVEIAVQNAH--QRWLGELPELAEY--QALVKAEQKKWEEQHEVSVNKRISFAV 903
E++ +Q+ I + A+ Q + EL E +A AEQ+ + V + + ++
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724
Query: 904 SEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKE 963
K+K +++L +L+ ++ ++ E+ I + A E KE
Sbjct: 1725 IHTKKKLETDL----------MQLQSEVEDASRDARNAEEKAKKAI-TDAAMMAEELKKE 1773
Query: 964 KQEEIHRIQEQNEQDYRQFLDDHRNKINE----VLAAAKEDFMKQKTELLLQKETELQTC 1019
+ H E+ +++ Q + D +++++E L K+ K +T + +E E +
Sbjct: 1774 QDTSAH--LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI---RELEFELE 1828
Query: 1020 LDQSRREWTMQEAKRIQLEI----YQYEEDILTVL 1050
+Q + +++ ++ + + YQ EED VL
Sbjct: 1829 GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Score = 75.1 bits (183), Expect = 5e-13
Identities = 169/842 (20%), Positives = 340/842 (40%), Gaps = 125/842 (14%)
Query: 632 QQQNQELKETEGKLRNTNQDLC------NQMRQMVQDFDHDKQEAVDRCERTYQQHHEAM 685
Q+ EL ++E K + + L N ++ VQ + +A +RC++ + + +
Sbjct: 858 QKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ-L 916
Query: 686 KTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLEL 745
+ +I+E + + A +++++ +L E +L K++ D+LEL
Sbjct: 917 EAKIKE--VTERAEDEEEINAELTAKKRKLEDECSELKKDI--------------DDLEL 960
Query: 746 TLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAM--KKKTLDCGSQTD----QVT 799
TL K +++ T+ K+K L ++L S LD+TI + +KK L Q Q
Sbjct: 961 TLAKVEKEKHATENKVKN-LTEEL-----SGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Query: 800 TSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAV 859
V S + +E+Q ++ +LEQEK + + K ++E +LK + +E
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 860 QNAHQRWLGELPELAEYQALVKAE-------QKKWEE--------QHEVSVNKRISFAVS 904
Q +R + E + Q+ V+ E QKK +E + E+ +
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 905 EAKEKWKSELENMRK-----------NILPGKELEEKIHSLQKELE---LKNEEVPVVIR 950
+ + + ELE + + I K+ E + L+++LE L++E + +R
Sbjct: 1135 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194
Query: 951 AELAKARSEWNKEKQEEIHRIQEQNEQDYRQF---LDDHRNKINEVLAAAKEDFMKQKTE 1007
+ A + +E E+ + + R++++ E++ +F +DD L+++ E K K
Sbjct: 1195 KKHADSVAELG-EQIDNLQRVKQKLEKEKSEFKLEIDD--------LSSSMESVSKSKAN 1245
Query: 1008 LLLQKETELQTCLDQ-SRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSD-TQKEHISDS 1065
L E +T DQ S +E +R E+ + + T G L +KE I
Sbjct: 1246 L----EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ 1301
Query: 1066 EDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDT---LPLLVENADPEWKKRNMAELS 1122
+ ++ K K + A Q + LL E + E + + + +
Sbjct: 1302 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1361
Query: 1123 KDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTL 1182
A+ Q + A+Q TE E K+ + L + ++ + +L
Sbjct: 1362 LSKANSEVAQWRT------KYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 1183 CKTPPRSLSAGAIENACLPCS-----GGALEELRGQYIKAVK--KIKC-----DMLRYIQ 1230
KT R G +E+ + AL++ + + K + K KC ++ ++
Sbjct: 1416 EKTKQR--LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 1473
Query: 1231 ESKERAAEMVKA----EVLRERQETARKMRK---YYLICLQQILQDDGK-----EGAEKK 1278
ES+ + E+ K E ++ ET ++ K + L + + ++GK E + K+
Sbjct: 1474 ESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Query: 1279 IMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSKRNDVNQKIPCCIES 1338
I + + + E + + ++K + L LT +K D ++I +
Sbjct: 1534 IELEKADIQLALEEAEAALEHE-EAKILRIQLELTQVKSEIDRKIAEKD--EEIEQLKRN 1590
Query: 1339 KSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETHLEFQFGDGSCKHLN 1398
+V T+ L + R A L++ +E + + + +H Q + + KHL
Sbjct: 1591 YQRTVETMQSALDAEVRSRNEAIRLKKKMEG----DLNEIEIQLSHANRQAAE-TLKHLR 1645
Query: 1399 SL 1400
S+
Sbjct: 1646 SV 1647
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 103 bits (257), Expect = 1e-21
Identities = 184/853 (21%), Positives = 355/853 (41%), Gaps = 119/853 (13%)
Query: 206 GSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENL---------- 255
G ++I+ + Q+ LG N + ++++L++ N++ + +E L
Sbjct: 430 GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 256 IEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKAL---- 311
K+ + E++ + L+ ++ I+++E SL+ Q L ++ + + QLE I+ L
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549
Query: 312 ETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTK--K 369
E QI+ L+ E + T +L Q + + + + HESI +K K
Sbjct: 550 ERQIKILEQENEHL----NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 370 YEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIK---------LEKTEII 420
E + ++K L+ KE+ + L++ + LE+ E ++ EK E +
Sbjct: 606 IEFEKRQIKKELEH----YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEAL 661
Query: 421 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE 480
+ LE ++ L S L FQL+ +K N L EE EL+
Sbjct: 662 EQENSELERENRKLKKTLDS-----FKNLTFQLESLEKE-------NSQLDEENLELRRN 709
Query: 481 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQE--EDPNEELS 538
+ + A+ EL E + L + K ++KK++ + + + N+ L
Sbjct: 710 VESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ 769
Query: 539 K-----DEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEV 593
K ++ I +L++E+Q L N LQ +L++ + L Q++K+ KS+E
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQT-------LQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 594 ETKTDTSEKPKNQLWPESST--SDVVRDDILLLKNEIQV--LQQQNQELKETEGKLRNTN 649
ET EK K QL E+ D L +N +++ L+++N+ L + G + +
Sbjct: 823 ETSQ--LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES- 879
Query: 650 QDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYE 709
C +++++ + + +E V R + +RE L+++ L+ QQ+ E
Sbjct: 880 ---CVRLKEL----EKENKELVKRATIDIKT-----LVTLREDLVSEK-LKTQQMNNDLE 926
Query: 710 RTHLQLRSELDK--LNKEVTAVQECYLEVCREK---DNLELTLRKTTEKEQQTQEKIKEK 764
+ L EL+K LNKE E + R K LE TL+K+ E +++ ++ +
Sbjct: 927 K----LTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEAR 982
Query: 765 LIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQ---VTTSDVISKKEMAIMIEEQKCTIQ 821
L + + +L Q +K +KK + D+ V +S IS ++ E Q+ T
Sbjct: 983 LEESTN--YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETT-- 1038
Query: 822 QNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVK 881
+ L + KD I+ ++ E + + KQ+E N QA +
Sbjct: 1039 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL--------------QAQIL 1084
Query: 882 AEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELK 941
A Q++ E + + A K ++EN N + + L ++ L+
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNA--------KLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
Query: 942 NEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDH--RNKINEVLAAAKE 999
NE V+ E K+ + + E++ + E+ +Y + H ++ L
Sbjct: 1137 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1196
Query: 1000 DFMKQKTELLLQK 1012
D + +LL QK
Sbjct: 1197 DLEDRYNQLLKQK 1209
Score = 90.1 bits (222), Expect = 2e-17
Identities = 199/969 (20%), Positives = 400/969 (41%), Gaps = 82/969 (8%)
Query: 244 LNKAKER--QLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKERE 301
+++ KER +E ++ E + + L +++D+ +G + S KL + KE
Sbjct: 329 VSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG---TRARSDKLHELEKEN- 384
Query: 302 IQLEAQIKALETQIQALKVNEEQMIKKSRTTEMA-LESLKQQLVDLHHSESLQRAREQHE 360
+QL+A++ +E + + E++++++ T EMA +S+ + L E + R E E
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444
Query: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERN-QEAIKLEKTEI 419
+ L + E S L+ +L + + L+ V +E N + +K+EK
Sbjct: 445 APQKSLGHEVNELTSSRLLKLEMENQSLTKTVE---ELRTTVDSVEGNASKILKMEKEN- 500
Query: 420 INKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKD 479
+L++ +E +L++ VQE LQ N++K L +E +L+
Sbjct: 501 -QRLSKKVE--------ILENEIVQEKQSLQ-----------NCQNLSKDLMKEKAQLEK 540
Query: 480 EISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQE--------E 531
I ++ I + E E L ++ L + +++V I +E +
Sbjct: 541 TIETLRENSERQIKILEQENE---HLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSI 591
+ + +LSK EF K ++++ L K +L+N+L K+ +L Q K I
Sbjct: 598 ETSSKLSKIEF---EKRQIKKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNLKI 653
Query: 592 EVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQD 651
E K + E+ ++L E+ D L +++ L+++N +L E +LR +
Sbjct: 654 TCE-KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 652 LCNQMRQMVQ------DFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLF 705
L +M Q + + +K++ E + + ++ L Q+
Sbjct: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
Query: 706 EAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKL 765
E + QL SEL L E +Q+ E+ LE ++ EQ+T + K+K
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK- 831
Query: 766 IQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLE 825
+QLEKE +L Q + + + + + KE+ I ++ C + LE
Sbjct: 832 -KQLEKE-NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY--KESCVRLKELE 887
Query: 826 QEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELA-EYQALVKAEQ 884
+E +K A ++ + L+ K + N ++ EL ++ + L+ EQ
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 885 KKWEEQHEVSVNKRISFAVS--EAKEKWKSELE-NMRKNILPGKELEEKIHSLQKELEL- 940
+ ++++ +K S E KE+ + LE + ++ ++L +++ +++K E
Sbjct: 948 STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1007
Query: 941 ---KNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAA 997
++EE V ++ ++W +E QE + + + + ++ RN N L A
Sbjct: 1008 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD----RLIEVERN--NATLQAE 1061
Query: 998 KEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDT 1057
K+ Q +L Q L R+ ++QE Q Q + L V L ++
Sbjct: 1062 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQE----QNTTLQTQNAKLQVENSTL-NS 1116
Query: 1058 QKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQD--TLPLLVENADPEWKK 1115
Q + + + L++ S + ++ E LK +D L LL E E++
Sbjct: 1117 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1176
Query: 1116 RNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEE-LIEENNDMKN 1174
+ SA + + + + Q L + + E+ KV +E ++ EN + +
Sbjct: 1177 LISKHGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET 1235
Query: 1175 KLEELQTLC 1183
E + LC
Sbjct: 1236 VAAEYKKLC 1244
Score = 80.1 bits (196), Expect = 2e-14
Identities = 187/861 (21%), Positives = 361/861 (41%), Gaps = 142/861 (16%)
Query: 473 ELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQE-E 531
EL+E +D + A+ P S G ++ TES L ++ + K+K+ + QE E
Sbjct: 213 ELSEERDGLHFLPHASSSAQSPCGSPG---MKRTESRQHLSVELAD-AKAKIRRLRQELE 268
Query: 532 DPNEEL--SKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEK 589
+ E+L K E + +++ E++RL N L +D + ++L ++ EK
Sbjct: 269 EKTEQLLDCKQE-LEQMEIELKRLQQENM-------NLLSDARSARMYRDELDALR--EK 318
Query: 590 SIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKET-------- 641
++ V+ + K +L DI K ++ L++ NQ L ET
Sbjct: 319 AVRVDKLESEVSRYKERL-----------HDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 642 EG---------KLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRES 692
EG +L N L ++ M + D D+++ + E A K + ES
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM-AQKQSMDES 426
Query: 693 LLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTE 752
L LE Q+ E + +S ++N E+T+ + LE+ +N LT KT E
Sbjct: 427 LHLGWELE--QISRTSELSEAPQKSLGHEVN-ELTSSRLLKLEM----ENQSLT--KTVE 477
Query: 753 KEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIM 812
+ + T + ++ + L K+++ + + KK ++ ++++ +K+
Sbjct: 478 ELRTTVDSVEGNASKIL------KMEKENQRLSKKV--------EILENEIVQEKQSL-- 521
Query: 813 IEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQ-NAH-QRWLGEL 870
Q C QNL KD+ + A + IE EN +Q++I Q N H + + L
Sbjct: 522 ---QNC---QNLS--KDLMKEKAQLEKTIETLR---ENSERQIKILEQENEHLNQTVSSL 570
Query: 871 PELAEY--QALVKAEQKKWEEQHEV--SVNKRISFAVSEAKEKWKSELENMRKNILPGKE 926
+ ++ +A VK +K+ + HE + ++S + K + K ELE+ ++ +E
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLS-KIEFEKRQIKKELEHYKEKGERAEE 629
Query: 927 LEEKIHSLQKELELKNEEVP-VVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDD 985
LE ++H L+KE EL +++ + I E +A + N E + E ++ ++ LD
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL--------KKTLDS 681
Query: 986 HRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEED 1045
+N ++ + KE+ + L L++ E C + + E K ++ E Q ++
Sbjct: 682 FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL-ENKELESEKEQLKKG 740
Query: 1046 ILTVLGVLLSDTQKEHIS----DSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDT 1101
L +L T++ +S D E+++L + + + K +Q E ++ Q T
Sbjct: 741 -LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK---IQQLESELQDLEMENQ-T 795
Query: 1102 LPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNK- 1160
L +E K+ E S Q T Q L+ + + E+ NK
Sbjct: 796 LQKNLEELKISSKRLEQLEKENKSLEQETSQ---------------LEKDKKQLEKENKR 840
Query: 1161 ------VVEELIEENNDMKNKLE-ELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQ 1213
+ + +EENN LE E +TL K G + +C+ L+EL +
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSK------EIGIYKESCV-----RLKELEKE 889
Query: 1214 YIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKE 1273
+ VK+ D+ + ++ +E +K + + E + + +++L D+
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 1274 GAEKKIMNAASKLATMAKLLE 1294
+ + + +T+ K LE
Sbjct: 950 DDSRYKLLESKLESTLKKSLE 970
Score = 77.0 bits (188), Expect = 1e-13
Identities = 155/776 (19%), Positives = 339/776 (43%), Gaps = 116/776 (14%)
Query: 235 NMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLF 294
+M++ QLQ+ NK E + E L + L + + ++ GL + + QK
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER----LEVSYQGLDIENQRLQKTL 772
Query: 295 QNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSES-LQ 353
+N ++ QLE++++ LE + Q L+ N E++ + + LE L+++ L S L+
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEEL----KISSKRLEQLEKENKSLEQETSQLE 828
Query: 354 RAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDI----------CSRLKDHVK 403
+ ++Q E L ++ E + +L++N KE + + C RLK+ K
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK 888
Query: 404 QLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMS 463
+ N+E +K +I +T L+ V E + Q
Sbjct: 889 E---NKELVKRATIDIKTLVT-------------LREDLVSEKLKTQ------------- 919
Query: 464 ANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKK-VNWKKS 522
MN L E+LT ++I L + +H S + +L ES ++ +KK + K+
Sbjct: 920 -QMNNDL-EKLTHELEKIGLNKERL---LHDEQSTDDSRYKLLESKLESTLKKSLEIKEE 974
Query: 523 KVTSIVQ--EEDPN---------EELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDL 571
K+ ++ EE N + + K+ LK + + +R++ S+ ++ + +
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 572 KDCHKKIEDLHQVKKDEKSIEVETKTDT--SEKP--KNQLWPESSTSDVVRDDILLLKNE 627
++ +++ +K ++ IEVE T +EK K QL + ++ ++ IL L+ +
Sbjct: 1035 QETTREL-----LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 628 IQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDH--DKQEAVDRCERTYQQHHEAM 685
LQ+QN L+ KL+ N L +Q ++ +Q +++ + + E +
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
Query: 686 KTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLEL 745
K+ + +SL+ H E E H + SE + L + ++ + + E +LE
Sbjct: 1150 KS-LYDSLIKDH--------EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200
Query: 746 TLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQV--TTSDV 803
+ +++ Q ++ K ++Q + ++K +T+ A KK CG + D++ T S +
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL--CG-ENDRLNHTYSQL 1257
Query: 804 ISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAH 863
+ + E+ +Q + + K + +++ +E E + +Q++I +
Sbjct: 1258 LKETEV----------LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1307
Query: 864 QRWLGELPELAEYQALVKAEQKKWEEQHEVSV--NKRISFAVSEAKEKWKSE----LENM 917
+ L++ + ++ E + +Q + + N+ + E+K+ + E ++ +
Sbjct: 1308 ----NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363
Query: 918 RKNILPGKELEEKIHSLQKELE-----LKNEEVPVVIRAELAKARSEWNKEKQEEI 968
+ ++LEEKI K + + + + +R +L K++ + N+E+Q+ +
Sbjct: 1364 NELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMR-KLIKSKKDINRERQKSL 1418
Score = 34.7 bits (78), Expect = 0.79
Identities = 46/247 (18%), Positives = 95/247 (38%), Gaps = 34/247 (13%)
Query: 1148 LQATEAEAEENNKVVEELIEENNDM----KNKLEELQTLCKTPPRSLSAGAIENACLPCS 1203
L E E + + K +EEL+EEN + K ++E L + + A
Sbjct: 391 LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSL 450
Query: 1204 GGALEELRGQYIKAVKKIKCDMLRYIQESKER--AAEMVKAEVLRERQETARKMRKYYLI 1261
G + EL + ++ + + ++E + + E +++L+ +E R +K ++
Sbjct: 451 GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 1262 CLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVK 1321
E +I+ L L + + K+Q + T L SE I +
Sbjct: 511 --------------ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKIL 556
Query: 1322 KSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSK 1381
+ + +NQ + + S + + ++ ++L H+SIK SK
Sbjct: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIEKE----------NKIL----HESIKETSSK 602
Query: 1382 ETHLEFQ 1388
+ +EF+
Sbjct: 603 LSKIEFE 609
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 102 bits (255), Expect = 2e-21
Identities = 190/894 (21%), Positives = 382/894 (42%), Gaps = 143/894 (15%)
Query: 230 ENSAENMQIIQLQVLNKAKER---QLENLIE----KLNES----ERQIRYLNHQLVIIKD 278
+ AE + ++++ LNK E + + LIE KLN++ ER++ L + +
Sbjct: 216 QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 275
Query: 279 EKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMAL-- 336
+ +K FQ +E L I L+T++Q ++ ++ K + + AL
Sbjct: 276 SLQASKEKEADLRKEFQG---QEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAI 332
Query: 337 -----ESLKQQLVDLHHSE-SLQRAREQHESIVMGLTKKYEEQVLSLQKN------LDAT 384
+ L++QL D E +L ++ ES + ++ ++Q L L AT
Sbjct: 333 AENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQAT 392
Query: 385 V----TALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQS 440
+K+ E SR+ + + QLE E+ + T+SL+E QKQ L+
Sbjct: 393 QMTQEVTIKDLESEKSRVNERLSQLE--------EERAFLRSKTQSLDEEQKQQILELEK 444
Query: 441 GSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEIS--LYESAAKLGIHPSDSE 498
V E + Q + + + N+ L+EE+T+L + S L E A K
Sbjct: 445 -KVNEAKRTQQEYYERELK-----NLQSRLEEEVTQLNEAHSKTLEELAWK--------- 489
Query: 499 GELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNS 558
+ IE S K K+ ++E+ ++L+ +E +L+ E++ L
Sbjct: 490 HHMAIEAVHS-------NAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLE 542
Query: 559 MKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIE-----VETKTDTSEKPKNQLWPESST 613
K + +Q L+D V+K E+ + + + D+ E+ +N+L +
Sbjct: 543 DKLNTANQEIGHLQD---------MVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDS 593
Query: 614 SDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQ--MVQDFDHDKQEAV 671
+D +L ++ E L+Q+ Q+ +ET ++ + ++M ++ ++ +QE
Sbjct: 594 LKETKDALLNVEGE---LEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 650
Query: 672 DRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD--------KLN 723
E QH E K+ + + L K EK +++++ L +++ +L+
Sbjct: 651 KLREELRLQHEEDKKSAMSQLLQLKDR-EKNAARDSWQKKVEDLLNQISLLKQNLEIQLS 709
Query: 724 KEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLI---QQLEKEWQSKLDQT 780
+ T++Q+ + +E+ L L + E+ QQ + +KE + Q +E+E + +
Sbjct: 710 QSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL 769
Query: 781 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE 840
+++K ++ + + S + I +E++ T++ LE E K + L
Sbjct: 770 ENHLQQKH---SAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEG----KAMLASLR 822
Query: 841 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS 900
EL +H I ++ N HQ ELA K E + + +++R S
Sbjct: 823 SELNHQHAAAI----DLLRHNHHQ-------ELAA---------AKMELERSIDISRRQS 862
Query: 901 ----FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKA 956
+++ +E+ + ++ + + L E I +L KELE K +E+ +
Sbjct: 863 KEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEI--------LRI 914
Query: 957 RSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETEL 1016
RSE N++ + + ++ E++ DH + N + A DF K ELL + L
Sbjct: 915 RSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRA----DFNKTN-ELLKEINAAL 969
Query: 1017 QTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQL 1070
Q L++ ++ M+E+K +++ + +LT ++ K+ I D++ QL
Sbjct: 970 QVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQII----KKLIEDNKFYQL 1019
Score = 93.2 bits (230), Expect = 2e-18
Identities = 163/800 (20%), Positives = 337/800 (42%), Gaps = 121/800 (15%)
Query: 348 HSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVK---- 403
H ++Q ++ HE + + + E++L + + + ++ + + S L+DH+K
Sbjct: 65 HESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQ 124
Query: 404 ----------QLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQS-GSVQ-------- 444
++E Q + + + I ++R +EE +++ L+S G +Q
Sbjct: 125 ALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKR 184
Query: 445 -EVAQLQF-------QLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHP-- 494
+ LQ +L ++Q+ H+ S N + EEL ++ E SL + +L +
Sbjct: 185 LALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVE-SLNKMLEELRLERKK 243
Query: 495 --SDSEGELNIELTESYVD-----LGIKKVNWKKSKVTSIVQEEDPNEELSKDEFIL--- 544
D EG+LN +S+ + L ++ +S S +E D +E E IL
Sbjct: 244 LIEDYEGKLN--KAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKT 301
Query: 545 --KLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEK 602
KLK E+Q + +LQ L ++ L + D K E+ + E
Sbjct: 302 IGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE- 360
Query: 603 PKNQLWPESSTSDVVRDDILLLKNEIQVLQ--QQNQE--LKETEGKLRNTNQDLCNQ--- 655
+++L D++L + I +LQ Q QE +K+ E + N+ L
Sbjct: 361 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 420
Query: 656 ---MRQMVQDFDHDK-------QEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLF 705
+R Q D ++ ++ V+ +RT Q+++E + ++L ++ E QL
Sbjct: 421 RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYE----RELKNLQSRLEEEVTQLN 476
Query: 706 EAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKL 765
EA+ +T +L K A++ + R+K L++ L + K++ E+ K +L
Sbjct: 477 EAHSKTLEELAW------KHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQL 530
Query: 766 IQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSD--VISKKEMAIMIEEQKCTIQQN 823
Q+LE + D+ + + G D V S+ + S + + +++ + +Q
Sbjct: 531 QQELENLKEVLEDK----LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNE 586
Query: 824 LEQEKDI--AIKGAMKKLEIELE---LKHCENITK-------QVEIAVQNAHQRWL---- 867
L+ KD K A+ +E ELE +H E I +V+ + +W
Sbjct: 587 LDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLR 646
Query: 868 GELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKEL 927
E +L E L E KK + + R A A++ W+ ++E +L
Sbjct: 647 QECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA---ARDSWQKKVE----------DL 693
Query: 928 EEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQ---EEIHRIQEQNEQDYRQFLD 984
+I L++ LE++ + + L + ++++ +E+Q +E+ ++EQ++Q ++ +
Sbjct: 694 LNQISLLKQNLEIQLSQ----SQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKE 749
Query: 985 DHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLD---QSRREWTMQEAKRIQLEIYQ 1041
H + +++ + L + ELQ+ D +S + ++ + +Q ++
Sbjct: 750 AHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFE 809
Query: 1042 YEEDILTVLGVLLSDTQKEH 1061
E++ +L L S+ +H
Sbjct: 810 LEDEGKAMLASLRSELNHQH 829
Score = 89.7 bits (221), Expect = 2e-17
Identities = 194/870 (22%), Positives = 347/870 (39%), Gaps = 132/870 (15%)
Query: 298 KEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRARE 357
+E +++ +I L I AL ++ ES Q L D H E Q E
Sbjct: 38 QEMHLKMSKKIAQLTKVIYALNTKNDEH-----------ESAIQALKDAHEEEIQQILAE 86
Query: 358 QHESIVMGLTKKYEE-------QVL--SLQKNLDATVTALKEQEDICSRLKD-------- 400
E I+ +K EE QVL SL+ ++ AL E E R++D
Sbjct: 87 TREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQ 146
Query: 401 HVKQL---ERNQEAIKL---EKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQ 454
HV+++ R E I+ EK +L E+ ++ LQ+ +E+ +L
Sbjct: 147 HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELL---- 202
Query: 455 QAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPS----DSEGELNIELT--ES 508
++Q+ H+ S N + EEL ++ E SL + +L + D EG+LN + E
Sbjct: 203 KSQQDHSASVNKGQEKAEELHRMEVE-SLNKMLEELRLERKKLIEDYEGKLNKAQSFYER 261
Query: 509 YVD-LGIKKVNWKKSKVTSIVQEEDPNEELSKDEFIL-----KLKAEVQRLLGSNSMKRH 562
+D L ++ +S S +E D +E E IL KLK E+Q +
Sbjct: 262 ELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLD 321
Query: 563 LVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDIL 622
+LQ L ++ L + D K E+ + E +++L D++
Sbjct: 322 KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEV-ESELAAARERLQQQASDLV 380
Query: 623 LLKNEIQVLQ--QQNQE--LKETEGKLRNTNQDLCNQ------MRQMVQDFDHDKQEA-- 670
L + I +LQ Q QE +K+ E + N+ L +R Q D ++++
Sbjct: 381 LKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQIL 440
Query: 671 -----VDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKE 725
V+ +RT Q+++E ++ L E QL EA+ +T +L K
Sbjct: 441 ELEKKVNEAKRTQQEYYERELKNLQSRLEE----EVTQLNEAHSKTLEELAW------KH 490
Query: 726 VTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMK 785
A++ + R+K L++ L + K++ E+ K +L Q+LE + D+ A +
Sbjct: 491 HMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQ 550
Query: 786 KKTLDCGSQTDQVTTSD--VISKKEMAIMIEEQKCTIQQNLEQEKDIA--IKGAMKKLEI 841
+ G D V S+ + S + + +++ + +Q L+ KD K A+ +E
Sbjct: 551 ----EIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEG 606
Query: 842 ELELK---HCENITK-------QVEIAVQNAHQRWLGELPE----LAEYQALVKAEQKKW 887
ELE + H E I +V+ + +W L + L E L E KK
Sbjct: 607 ELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKS 666
Query: 888 EEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKE-----LEEKIHSLQK------ 936
+ + R A A++ W+ ++E++ I K+ L + SLQ+
Sbjct: 667 AMSQLLQLKDREKNA---ARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFT 723
Query: 937 -----------ELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDD 985
ELE ++++ ++ A +EK++E ++ +Q + L
Sbjct: 724 QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQS 783
Query: 986 HRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEED 1045
++ E + + + ++ L + E E + L R E Q A I L + + ++
Sbjct: 784 LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQE 843
Query: 1046 ILTV-----LGVLLSDTQ-KEHISDSEDKQ 1069
+ + +S Q KEHI D Q
Sbjct: 844 LAAAKMELERSIDISRRQSKEHICRITDLQ 873
Score = 36.6 bits (83), Expect = 0.21
Identities = 84/437 (19%), Positives = 184/437 (42%), Gaps = 54/437 (12%)
Query: 820 IQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQAL 879
IQQ L + ++ ++ K E EL+L+ + +E ++++ + L E Y+
Sbjct: 80 IQQILAETREKILQYKSKVTE-ELDLRRKIQV---LESSLEDHIKMKQQALTEFEAYKHR 135
Query: 880 VKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELE 939
V+ Q E QH + +S V E + K++ +L + + L + ++K +L+
Sbjct: 136 VEDMQLCAEAQHVQRI-VTMSREVEEIRRKFEEKLRSFGQ--LQVQFEKDKRLALEDLQA 192
Query: 940 LKNEEVPVVIRAELAKARS-EWNKEKQEEIHRIQ--------EQNEQDYRQFLDDHRNKI 990
E+ +++++ + S +EK EE+HR++ E+ + ++ ++D+ K+
Sbjct: 193 AHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKL 252
Query: 991 NEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYEEDILTVL 1050
N+ + F +++ + L + + L S+ ++ ++ E E + +
Sbjct: 253 NKA-----QSFYERELDTLKRSQLFTAESLQASK-----EKEADLRKEFQGQEAILRKTI 302
Query: 1051 GVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENAD 1110
G L ++ Q + D L + ++ ++ + L+ + A + + LL ++ +
Sbjct: 303 GKLKTELQM--VQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 360
Query: 1111 PEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENN 1170
E + E + AS D A H LQAT+ E K +E N
Sbjct: 361 VESELAAARERLQQQAS------DLVLKASHIGM---LQATQMTQEVTIKDLESEKSRVN 411
Query: 1171 DMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQ 1230
+ ++LEE + ++ +SL EE + Q ++ KK+ + R Q
Sbjct: 412 ERLSQLEEERAFLRSKTQSLD----------------EEQKQQILELEKKVN-EAKRTQQ 454
Query: 1231 ESKERAAEMVKAEVLRE 1247
E ER + +++ + E
Sbjct: 455 EYYERELKNLQSRLEEE 471
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 102 bits (254), Expect = 3e-21
Identities = 206/1048 (19%), Positives = 432/1048 (41%), Gaps = 158/1048 (15%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER-------E 301
+ E E+L SE + + L ++V + EK+ L L ++ + + +ER +
Sbjct: 857 KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSK 916
Query: 302 IQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHES 361
I LEA++K L +++ + +++ K R E SLK+ + DL E E+ +
Sbjct: 917 ILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL---ELTLTKVEKEKH 973
Query: 362 IVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIIN 421
K E++ +L++N+ K ++ + D ++ ++ +K +
Sbjct: 974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ--------VEEDKVNGLI 1025
Query: 422 KLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEI 481
K+ LE+ GS+++ +L+ L++A++ M+ QE + +L+++
Sbjct: 1026 KINAKLEQQTDDL-----EGSLEQEKKLRADLERAKRKLEGDLKMS---QESIMDLENDK 1077
Query: 482 SLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDE 541
E K E EL+ +L D + + ++K K+ + + EE + E
Sbjct: 1078 QQIEEKLK------KKEFELS-QLQAKIDDEQVHSLQFQK-KIKELQARIEELEEEIEAE 1129
Query: 542 FILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLH-----QVKKDEKSIEVETK 596
L+ K E QR S L +L++ +++E+ Q++ ++K E E +
Sbjct: 1130 HTLRAKIEKQR------------SDLARELEEISERLEEASGATSAQIEMNKKR-EAEFQ 1176
Query: 597 TDTSEKPKNQLWPESSTSDVVR---DDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLC 653
+ + L E++ + + + D + L +I LQ+ Q+L++ + +L+ D+
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236
Query: 654 NQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHL 713
+ + + + + ++R RT + +K + + H L Q+
Sbjct: 1237 SNIEALSK-----SKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK---------A 1282
Query: 714 QLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEW 773
+L+++ +L+ V EK++L L K+ + Q E++K +Q+E+E
Sbjct: 1283 RLQTQNGELSHRV-----------EEKESLISQLTKSKQALTQQLEELK----RQMEEET 1327
Query: 774 QSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDI--- 830
++K + A++ DC +Q + + + Q + E D
Sbjct: 1328 KAK-NAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 831 --AIKGAMKKLEIELELKHCENITKQVEIA-VQNAHQRWLGELPELAEYQALVKAEQKKW 887
++ A KKL L+ T + A ++ QR GE+ +L +
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL----------MRDL 1436
Query: 888 EEQHEVSV---NKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKEL-ELKNE 943
E H K+ +F + +WK +L+ + + + +++ SL EL +++N
Sbjct: 1437 ERSHTACATLDKKQRNF--DKVLAEWKQKLDESQAEL---EAAQKESRSLSTELFKMRNA 1491
Query: 944 EVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMK 1003
VV + E + NK QEEI + EQ + + + + K
Sbjct: 1492 YEEVVDQLETLRRE---NKNLQEEISDLTEQIAETGKNLQEAEKTK-------------- 1534
Query: 1004 QKTELLLQKETELQTCLDQSRREWTMQEAK--RIQLEIYQYEEDILTVLGVLLSDTQKEH 1061
+L+ Q++++LQ L++ +E+K R+QLE+ Q + ++ V+ D + E
Sbjct: 1535 ---KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSEL--DRKVIEKDEEIEQ 1589
Query: 1062 ISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAEL 1121
+ + + + S ++ S +LK +K D + ++ R MAE
Sbjct: 1590 LKRNSQRAAEALQSVLDAEIRSRNDALRLK---KKMEGDLNEMEIQLGH---SNRQMAET 1643
Query: 1122 SKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEE----LIEENNDMKNKLE 1177
K T QG + H AL++ E + +E +VE L+EE +MK LE
Sbjct: 1644 QKHLR---TVQGQLKDSQLHLDD--ALRSNE-DLKEQLAIVERRNGLLLEELEEMKVALE 1697
Query: 1178 ELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESK---E 1234
+ + + + L + L +L + + + + + ++ IQES+ E
Sbjct: 1698 QTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEE 1757
Query: 1235 RAAEMV-----KAEVLRERQETARKMRK 1257
+A + + AE L++ Q+T+ + +
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLER 1785
Score = 99.0 bits (245), Expect = 3e-20
Identities = 167/776 (21%), Positives = 324/776 (41%), Gaps = 116/776 (14%)
Query: 246 KAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRES-QKLFQNGKEREIQL 304
KAK+ Q LI LN + +++ N +L +EK+ L L +S Q L Q +E + Q+
Sbjct: 1264 KAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQM 1323
Query: 305 EAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSES-LQRAREQHESIV 363
E + KA AL+ + + L++Q + +++ LQRA + S V
Sbjct: 1324 EEETKAKNAMAHALQSSRHD-----------CDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 364 MGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLE-RNQEAIKLEKTE---- 418
KYE + + L+ + ++ + RL++ + E N + LEKT+
Sbjct: 1373 AQWRTKYETDAIQRTEELE------EAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQ 1426
Query: 419 -IINKLTRSLEESQKQCAHL--LQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELT 475
+ L R LE S CA L Q + +A+ + +L ++Q + +++L EL
Sbjct: 1427 GEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELF 1486
Query: 476 ELKDEI-SLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPN 534
++++ + + L + + E++ +LTE + G +K+K +V++E +
Sbjct: 1487 KMRNAYEEVVDQLETLRRENKNLQEEIS-DLTEQIAETGKNLQEAEKTK--KLVEQEKSD 1543
Query: 535 EELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVE 594
+++ +E L+ E ++L + +SQ++++L D ++KDE E+E
Sbjct: 1544 LQVALEEVEGSLEHEESKIL----RVQLELSQVKSEL--------DRKVIEKDE---EIE 1588
Query: 595 TKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCN 654
S++ L R+D L LK +++ +L E E +L ++N+ +
Sbjct: 1589 QLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME------GDLNEMEIQLGHSNRQMAE 1642
Query: 655 QMRQM--VQDFDHDKQEAVDRCERTYQQHHEAMK-TQIRESLLAKHALEKQQLFEAYERT 711
+ + VQ D Q +D R+ + E + + R LL + E + E ERT
Sbjct: 1643 TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERT 1702
Query: 712 HLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEK 771
EL + V + + K LE + Q Q +++ + +
Sbjct: 1703 RRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADI-------AQCQAEVENSIQESRNA 1755
Query: 772 EWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIA 831
E ++K T AM + L + +Q T++ + + M +E+ +Q L++ + +A
Sbjct: 1756 EEKAKKAITDAAMMAEEL----KKEQDTSAHL---ERMKKNLEQTVKDLQHRLDEAEQLA 1808
Query: 832 IKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQH 891
+KG K +++ EN +++E + +R L +Y+ VK + EE H
Sbjct: 1809 LKGGKK------QIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDH 1862
Query: 892 EVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRA 951
KNIL ++L +K+ + K + + EE
Sbjct: 1863 ---------------------------KNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895
Query: 952 ELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTE 1007
+L++ R R+Q + E+ + D +++N+ L A D QK E
Sbjct: 1896 QLSRCR------------RVQHELEEAAER-ADIAESQVNK-LRAKSRDVGSQKME 1937
Score = 82.4 bits (202), Expect = 3e-15
Identities = 146/688 (21%), Positives = 275/688 (39%), Gaps = 146/688 (21%)
Query: 655 QMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRES--LLAKHALEKQQLFEAYERTH 712
+M M +DF+ K+E R E ++ E M + ++E L + E + L +A ER
Sbjct: 852 EMATMKEDFERTKEELA-RSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCE 910
Query: 713 LQLRSEL----------------DKLNKEVTAVQECYLEVC----REKDNLELTLRKTTE 752
++S++ +++N E+ A + + C R+ D+LELTL K +
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEK 970
Query: 753 KEQQTQEKIK---------EKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDV 803
++ T+ K+K E+ I +L KE +S ++ ++TLD QV V
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKS-----LQEAHQQTLD----DLQVEEDKV 1021
Query: 804 ISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAH 863
++ +E+Q ++ +LEQEK + K ++E +LK + +E Q
Sbjct: 1022 NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIE 1081
Query: 864 QRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILP 923
++ + EL++ QA + EQ H + K+I
Sbjct: 1082 EKLKKKEFELSQLQAKIDDEQV-----HSLQFQKKI------------------------ 1112
Query: 924 GKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFL 983
KEL+ +I L++E+E ++ +RA++ K RS+ +E +E R++E + Q
Sbjct: 1113 -KELQARIEELEEEIEAEH-----TLRAKIEKQRSDLARELEEISERLEEASGATSAQI- 1165
Query: 984 DDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYE 1043
NK E +F K + +L +E LQ EA L + +
Sbjct: 1166 --EMNKKREA------EFQKMRRDL---EEATLQ------------HEATAATLR--KKQ 1200
Query: 1044 EDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLP 1103
D + LG + + Q+ + +K+ E+ +++ K K I++ +
Sbjct: 1201 ADSVAELGEQIDNLQR--VKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258
Query: 1104 LLVE-NADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVV 1162
E A E + + + +L+ A T G+ EE ++
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE----------------LSHRVEEKESLI 1302
Query: 1163 EELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIK 1222
+L + + +LEEL+ + ++ +A A AL+ R
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMA----------HALQSSRHD--------- 1343
Query: 1223 CDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKKIMNA 1282
CD+LR E ++ A ++ + + E A+ KY +Q + + E A+KK+
Sbjct: 1344 CDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQ---RTEELEEAKKKL--- 1397
Query: 1283 ASKLATMAKLLETPISSKSQSKTTQSAL 1310
A +L + ET S + + T+ L
Sbjct: 1398 AQRLQEAEENTETANSKCASLEKTKQRL 1425
Score = 45.8 bits (107), Expect = 3e-04
Identities = 68/328 (20%), Positives = 138/328 (42%), Gaps = 27/328 (8%)
Query: 223 QQFLGANENSAENMQ-IIQLQVLNKAKERQLENLIE-KLNESERQIRYLNHQLVIIKDEK 280
+Q ++ +AE +Q ++ ++ ++ +L+ +E LNE E Q+ + N Q+ +
Sbjct: 1588 EQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHL 1647
Query: 281 DGLTLSLRESQKLFQNGKEREIQLEAQIKALET-------QIQALKVNEEQMIKKSRTTE 333
+ L++SQ + L+ Q+ +E +++ +KV EQ + R +E
Sbjct: 1648 RTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSE 1707
Query: 334 MALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQED 393
Q+L+D S+ +Q Q+ S++ KK E + Q ++ ++ + E+
Sbjct: 1708 -------QELLDA--SDRVQLLHSQNTSLI-NTKKKLEADIAQCQAEVENSIQESRNAEE 1757
Query: 394 ICSRLKDHVKQLERNQEAIKLEK--TEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQF 451
+ K + E +K E+ + + ++ ++LE++ K H L + +
Sbjct: 1758 ---KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1814
Query: 452 QLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVD 511
Q+Q+ + N Q+ E YE K + ++ E NI + VD
Sbjct: 1815 QIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAE-EDHKNILRLQDLVD 1873
Query: 512 LGIKKVNWKKSKVTSIVQEEDPNEELSK 539
KV K K + EE N +LS+
Sbjct: 1874 KLQAKV--KSYKRQAEEAEEQANTQLSR 1899
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 102 bits (254), Expect = 3e-21
Identities = 180/829 (21%), Positives = 360/829 (43%), Gaps = 106/829 (12%)
Query: 212 ITGSDTFEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKL-NESERQ---IR 267
+T T +G+ ++ + E Q + Q+ + E ++ +L +KL NE E++ R
Sbjct: 816 LTNLQTIQGILER------SETETKQRLSSQI--EKLEHEISHLKKKLENEVEQRHTLTR 867
Query: 268 YLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIK 327
L+ QL+ K + D T +++L +N ++ L+ + +E Q+ + +
Sbjct: 868 NLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS---------Q 918
Query: 328 KSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGL------TKKYEEQVLSLQKNL 381
S+ T S K+ + DL L++ EQ + L ++Y+ V SL+++L
Sbjct: 919 SSQRTGKGQPSNKEDVDDL--VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESL 976
Query: 382 DATVTALKE-QEDICSRLKDHVK---QLERNQEAIKLEKTEIINKLTRSLEESQKQCAHL 437
+ +E +++I RLK+ + QLE+ ++ EK E+ + R++E ++Q + L
Sbjct: 977 NKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSEL 1036
Query: 438 LQS-GSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSD 496
++ SVQ ++Q LQ+A A + + QE+ + + YE +L +H +D
Sbjct: 1037 KKTLSSVQN--EVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYER--ELMLHAAD 1092
Query: 497 SEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGS 556
E ++ + SK+ S+ Q + + ++ + +L+ KA +
Sbjct: 1093 VEA--------------LQAAKEQVSKMASVRQHLEETTQKAESQ-LLECKASWEE---R 1134
Query: 557 NSMKRHLVSQLQNDLKDCHKKIEDLH-QVKKDEKSIEVETKTDTSEKPKNQLWPESSTSD 615
M + VS+ +D K+ LH Q++K + K L E + +
Sbjct: 1135 ERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE 1194
Query: 616 VVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCE 675
+ + + ++ E ++ + + E+ + E +L + Q +QD + ++E V
Sbjct: 1195 QILEILRFIRREKEIAETRF-EVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTA 1253
Query: 676 RTYQQHHEAMK-TQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYL 734
+T QH E MK T+ ++ + + +++ E E+ Q+++++ KL ++ +QE
Sbjct: 1254 KTMAQHEELMKKTETMNVVMETNKMLREEK-ERLEQDLQQMQAKVRKLELDILPLQEANA 1312
Query: 735 EVCR-------EKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKK 787
E+ EK LE +++ + Q + K+ ++ K K T K +++
Sbjct: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT-KRIQQL 1371
Query: 788 TLDCGSQTDQVTTSD---------VISKKEMAIMIEEQKCTIQQNLE------QEKDIAI 832
T + G ++ S+ + S KE + +K TIQ++L+ QEK I
Sbjct: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTI 1431
Query: 833 KGAMK-----KLEIELELKHCENITKQVEIAVQNAHQRW---LGELPELAEYQALVKAEQ 884
K K + E ELK ++ + HQ + E+ EL E + +
Sbjct: 1432 TQVKKIGRRYKTQYE-ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKS 1490
Query: 885 KKWEEQHEVSVNKRISFAVSEAKE------KWKSELENMRKNILPGKELEEKIHSLQKEL 938
K E Q E ++ K +S +EA+ + +SEL +R+++ EE++ E
Sbjct: 1491 KSLESQVE-NLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK 1549
Query: 939 ELKNEEVPVVIR---AELAKARSEWNKEKQEEIHR----IQEQNEQDYR 980
E K + V + A LA + + KE +E R Q+++E D R
Sbjct: 1550 EEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVR 1598
Score = 92.8 bits (229), Expect = 2e-18
Identities = 223/1195 (18%), Positives = 482/1195 (40%), Gaps = 189/1195 (15%)
Query: 246 KAKERQLENLIEKLNESER----QIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKERE 301
K +E++LE E L+ +++ +L+ + EK L L+ + +N KE
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCN---LENKKEEV 233
Query: 302 IQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHES 361
+LE Q+ L+T + L+ + E ++ K + + S++++ H+E A + +
Sbjct: 234 SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF----HNEL--NAHIKLSN 287
Query: 362 IVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIIN 421
+ E + L + ++ LKE + ++DH+ ++E++++ ++ E E I
Sbjct: 288 LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIG 347
Query: 422 KLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEI 481
+L + LE + + + G++ +L + A A++ + + +LTEL +
Sbjct: 348 RLEKELENANDLLSATKRKGAILSEEEL---AAMSPTAAAVAKIVKPGM--KLTELYNAY 402
Query: 482 SLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDE 541
+++ +L +E E+ K++N ++ V+ + P + ++E
Sbjct: 403 -------------VETQDQLLLEKLEN------KRINKYLDEIVKEVEAKAPILKRQREE 443
Query: 542 FILKLKAEVQRLLGSNSMK-RHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS 600
+ Q+ + S S+K + ++Q +D K + +++D + +E++ K D S
Sbjct: 444 Y-----ERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVK-DLS 497
Query: 601 EKPKNQLW--PESSTSDVVRDDILL---LKNEIQVLQQQNQELKETEGKLRNTNQDLCNQ 655
++ + L E+ + V+RD+ + + + +V+ Q + E +L+ NQ L
Sbjct: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIE-ELQQQNQRLLVA 556
Query: 656 MRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQL 715
+R++ + + ++QE Q E+ T++ + L K + QL ++ R
Sbjct: 557 LRELGETREREEQETTSSKITELQLKLESALTELEQ--LRKSRQHQMQLVDSIVRQRDMY 614
Query: 716 R---------------SELDKLNKEVTAVQECYLEV-----------CREKDNLELTLRK 749
R S LD ++ T + + E + L++
Sbjct: 615 RILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQ 674
Query: 750 TTE------KEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDV 803
E KE+ EKI+ + +++L+++ Q K + LD S+ ++ +V
Sbjct: 675 LQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ--LDFASKRYEMLQDNV 732
Query: 804 ISKKEMAIMIEEQKCTIQQNLEQEKDIA------IKGAMKKL---EIELE-LKHCENITK 853
+ + E+ + ++++ I ++GA +KL E+ E LK + + K
Sbjct: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLK 792
Query: 854 QVEIAVQNAHQRWLGE-------LPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEA 906
E+ + + L E L L Q +++ + + +++ + K + +S
Sbjct: 793 LSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK-LEHEISHL 851
Query: 907 KEKWKSELE-------NMRKNILPGK---ELEEKIHSLQKELELKNEEVPV-VIRAELAK 955
K+K ++E+E N+ +L K + E +H KEL LKN + + ++ L+
Sbjct: 852 KKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKEL-LKNAQKEIATLKQHLSN 910
Query: 956 ARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETE 1015
+ + + + Q N++D + R +V ++ +K T + Q +
Sbjct: 911 MEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV--NDLKERLKTSTSNVEQYQAM 968
Query: 1016 LQTCLDQSRREWTMQEAKRIQLEIYQYEE-DILTVLGVLLSDTQKEHISDSEDK------ 1068
+ + + +E + E R +E+ E + T L L + +KE +DK
Sbjct: 969 VTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIES 1028
Query: 1069 ---QLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDS 1125
QL E+ T SS ++ +Q+A Q L + A+++ ++
Sbjct: 1029 MEQQLSELKKTLSS----------VQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEA 1078
Query: 1126 ASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKT 1185
++ + H A ALQA + + + V + L E +++L E + +
Sbjct: 1079 QNKYERE-----LMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEE 1133
Query: 1186 PPRSLSAGAIENACLPCSG---------GALEELRGQYIKAVK----------------- 1219
R L + C C +E+L + + +VK
Sbjct: 1134 RERMLKDEVSKCVC-RCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKS 1192
Query: 1220 -KIKCDMLRYIQESKERAA---EMVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGA 1275
+ ++LR+I+ KE A E+ + E LR RQ R+ LQ++ D
Sbjct: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE-----LQEL--QDSLNAE 1245
Query: 1276 EKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSKRNDVNQ 1330
+K+ A +A +L+ + T + + T++ML K+ D+ Q
Sbjct: 1246 REKVQVTAKTMAQHEELM--------KKTETMNVVMETNKMLREEKERLEQDLQQ 1292
Score = 73.9 bits (180), Expect = 1e-12
Identities = 136/624 (21%), Positives = 257/624 (41%), Gaps = 99/624 (15%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQL---- 304
+ Q + +E N+ ER++ + ++ K+ ++ Q L + ++ E QL
Sbjct: 1069 QEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECK 1128
Query: 305 ---EAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHES 361
E + + L+ ++ E + K++R +E L ++V S++ + +
Sbjct: 1129 ASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVV-----ASVKEGVQGPLN 1183
Query: 362 IVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIIN 421
+ + K +EQ+L + + + +E + + V Q+E L + +
Sbjct: 1184 VSLSEEGKSQEQILEILRFI--------RREKEIAETRFEVAQVE------SLRYRQRVE 1229
Query: 422 KLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQA-QKAHAMSANM--NKALQEELTELK 478
L R L+E Q + VQ A+ Q ++ +K M+ M NK L+EE L+
Sbjct: 1230 LLERELQELQDSLN--AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLE 1287
Query: 479 DEISLYESAAK---LGIHPSDSEGELNIELTESYVDLGIKKV-------NWKKSKVTSIV 528
++ ++ + L I P E N EL+E L +K WK +
Sbjct: 1288 QDLQQMQAKVRKLELDILPLQ---EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
Query: 529 QEEDPNEE-----LSKDEF-----------ILKLKAEVQRLLGSNSMKRHLVSQLQNDLK 572
Q++DP+ E LS+ E I +LKAE+ R S + ++L+ L+ DL
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
Query: 573 DCHKKIEDLHQVKKDEKSIEVETKTDT-------SEKPKNQLWPESSTSDVVRDDILLLK 625
+ E + Q D K I+++ K T + K Q + D V +
Sbjct: 1405 KVRTEKETI-QKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSS 1463
Query: 626 NEIQ---VLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHH 682
+ Q V Q+ QELKET + ++ L +Q+ + + + EA + E+T Q
Sbjct: 1464 GDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQS 1523
Query: 683 EAMKTQIRESLLAKHALE---KQQLFEAYERTH----------LQLRSELDKLNKEVTAV 729
E +++R+ L + E +QQ+ E E+T L D+L KE +
Sbjct: 1524 EL--SRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEEL 1581
Query: 730 QECYLEVCREKDNLELTLRKTTEKEQ------QTQEKIKEKLIQQLE-----KEWQSKLD 778
++ + ++KD EL +R T K Q + + +++E + LE +E +K+
Sbjct: 1582 KQRNGALDQQKD--ELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVP 1639
Query: 779 QTIKAMKKKTLDCGSQTDQVTTSD 802
+ + + KT + +TSD
Sbjct: 1640 EQQRQITLKTTPASGERGIASTSD 1663
Score = 61.2 bits (147), Expect = 8e-09
Identities = 87/393 (22%), Positives = 182/393 (46%), Gaps = 47/393 (11%)
Query: 245 NKAKERQLENLIEKLNESERQIRYLNHQLVIIKD------EKDGLTLSLRESQKLFQNG- 297
NK + E L + L + + ++R L ++ +++ EK G+ L+ +KL +
Sbjct: 1276 NKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGM---LQAEKKLLEEDV 1332
Query: 298 ---KEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQR 354
K R L +Q K +T+ + K+ E+ + R ++ E + + + SL
Sbjct: 1333 KRWKARNQHLVSQQKDPDTE-EYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTN 1391
Query: 355 AREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKL 414
+ +S+ L K E+ ++QK+LDA + ++E+ +++K ++ + E +K
Sbjct: 1392 NQNLIQSLKEDLNKVRTEKE-TIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKA 1450
Query: 415 EKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQ-KAHAMSA---NMNKAL 470
++ +++ +S + Q+Q H+ SVQE+ +L+ L QA+ K+ ++ + N+ K L
Sbjct: 1451 QQDKVMETSAQSSGDHQEQ--HV----SVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
Query: 471 QEELTELKD----EISLYESAAKLGIHPSD---SEGELNIELTESYVDLGIKKVNWKKSK 523
E+ TE ++ + L ++L D E +L ++TE + K + KSK
Sbjct: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK-EEKTRKAIVAAKSK 1563
Query: 524 VTSIVQEED----PNEEL---------SKDEFILKLKAEVQRLLGSNS-MKRHLVSQLQN 569
+ + +D NEEL KDE +++ A + G S ++R L +
Sbjct: 1564 IAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQER 1623
Query: 570 DLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEK 602
L+ + E ++V + ++ I ++T + E+
Sbjct: 1624 HLEQRDEPQEPSNKVPEQQRQITLKTTPASGER 1656
Score = 49.3 bits (116), Expect = 3e-05
Identities = 45/190 (23%), Positives = 88/190 (46%), Gaps = 17/190 (8%)
Query: 222 QQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKD 281
Q+Q + E + Q + +K+ E Q+ENL + L+E E + R L Q V ++ E
Sbjct: 1467 QEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELS 1526
Query: 282 GLTLSLR----ESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALE 337
L L+ + ++L Q E+E + I A +++I L ++Q+ K++ E
Sbjct: 1527 RLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN-------E 1579
Query: 338 SLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSR 397
LKQ+ + +L + +++ + + L +YE ++ L++ L EQ D
Sbjct: 1580 ELKQR------NGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQE 1633
Query: 398 LKDHVKQLER 407
+ V + +R
Sbjct: 1634 PSNKVPEQQR 1643
Score = 48.9 bits (115), Expect = 4e-05
Identities = 58/222 (26%), Positives = 105/222 (47%), Gaps = 28/222 (12%)
Query: 218 FEGLQQQFLGANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIK 277
+E L+ Q E SA++ Q Q ++ ++++ L E LN++E + + L Q+
Sbjct: 1445 YEELKAQQDKVMETSAQSSGDHQEQHVSV---QEMQELKETLNQAETKSKSLESQV---- 1497
Query: 278 DEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQM----IKKSRTTE 333
+ L +L E + +N +E+ +QL++++ L +Q EEQ+ +K T
Sbjct: 1498 ---ENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554
Query: 334 MALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKN-LDATVTALKEQ- 391
A+ + K ++ L + Q +E E K L QK+ LD +TALK Q
Sbjct: 1555 KAIVAAKSKIAHLAGVKD-QLTKENEE-------LKQRNGALDQQKDELDVRITALKSQY 1606
Query: 392 EDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQ 433
E SRL+ ++L +QE LE+ + + + + E Q+Q
Sbjct: 1607 EGRISRLE---RELREHQER-HLEQRDEPQEPSNKVPEQQRQ 1644
Score = 46.6 bits (109), Expect = 2e-04
Identities = 115/574 (20%), Positives = 233/574 (40%), Gaps = 113/574 (19%)
Query: 557 NSMKRHLVSQLQNDLKDCHKKIEDLH------QVKKDEKSIEVETKTDTSEKPKNQLWPE 610
N + + + ++L+ L D +I+ L +V+ +++ E+E + S++ +L E
Sbjct: 15 NKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE---RLVNE 71
Query: 611 SSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEA 670
+ +R ++ L N+++ L ++N+EL+ + D+ A
Sbjct: 72 TRECQSLRLELEKLNNQLKALTEKNKELEIAQ-----------------------DRNIA 108
Query: 671 VDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQ 730
+ ++ T+ +E L A EK+ L RT+ +L EL+ L ++V +
Sbjct: 109 I-----------QSQFTRTKEELEA----EKRDLI----RTNERLSQELEYLTEDVKRLN 149
Query: 731 ECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLD 790
E E K L+L L + + K +EK ++Q EKE + + K
Sbjct: 150 EKLKESNTTKGELQLKLDEL--QASDVSVKYREKRLEQ-EKELLHSQNTWLNTELK---- 202
Query: 791 CGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCEN 850
++TD++ + +E I E KC ++ E+ + + K E KH E+
Sbjct: 203 --TKTDEL----LALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVED 256
Query: 851 -ITKQVEIAVQNA--HQRWLGELPELAEYQALVK-----AEQKKWEEQHEVSVNKRISFA 902
+TK E Q A +++ EL + L K +E K E V ++
Sbjct: 257 LLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKE 316
Query: 903 VSEAKEKWKSE-LENMRKNILPGKELEEKIHSLQKELE---------------LKNEEVP 946
EA + + LE + KE+ EKI L+KELE L EE+
Sbjct: 317 AGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELA 376
Query: 947 VVIRAELAKARSEWNKEKQEEIHR----------IQEQNEQDYRQFLDDHRNKIN---EV 993
+ A A+ K E++ +++ + ++LD+ ++ +
Sbjct: 377 AMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPI 436
Query: 994 LAAAKEDF---------MKQKTELLLQKETELQTCLDQSRREWTMQEA--KRIQLEIYQY 1042
L +E++ + K E +++ LQ D++ ++ ++ E +R+++++
Sbjct: 437 LKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDL 496
Query: 1043 EEDILTVLGVLLSDTQKEHISDSEDKQLLEIMST 1076
+ I VL + L + + H+ E+ +I S+
Sbjct: 497 SQQI-RVLLMELEEARGNHVIRDEEVSSADISSS 529
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 102 bits (254), Expect = 3e-21
Identities = 220/1017 (21%), Positives = 432/1017 (42%), Gaps = 149/1017 (14%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER-------E 301
+ + E E+L ++E + + L ++V + EK+ L L ++ + +ER +
Sbjct: 857 KEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTK 916
Query: 302 IQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHS-ESLQRAREQHE 360
IQLEA+IK + + + + ++ K R E LK+ + DL + +++ + E
Sbjct: 917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 976
Query: 361 SIVMGLTKK---YEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKT 417
+ V LT++ +E + L K A A ++ D +D V L + + IKLE+
Sbjct: 977 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK--IKLEQQ 1034
Query: 418 EIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTEL 477
++ L SLE+ +K ++ + +L+ L+ AQ++ N + L E+L +
Sbjct: 1035 --VDDLEGSLEQEKK-----IRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 478 KDEISLYESAAK----LGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDP 533
+ E+S +S + LG+ EL + E ++ ++ + K++ Q D
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE----KQRSDL 1143
Query: 534 NEELSK-DEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDC---HKKIEDLHQVKKDEK 589
+ EL + E + + + N + +++ DL++ H+ + K +
Sbjct: 1144 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1203
Query: 590 SIEVETKTDTSEKPKNQLWPESSTSDVVRDDILL-----------LKNEIQVLQQQNQEL 638
E+ + D ++ K +L E S + DD+ L+ + L+ Q E+
Sbjct: 1204 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEI 1263
Query: 639 KETEGKLRNTNQDLCNQ-MRQMVQDFDHDKQ--------EAVDRCERTYQQHHEAMKTQI 689
K E + + DL Q R + ++ +Q + R ++ + Q E +K Q+
Sbjct: 1264 KTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL 1323
Query: 690 RESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCR--EKDNLELTL 747
E + AK AL A + + R + D L ++ QE E+ R K N E+
Sbjct: 1324 EEEIKAKSALA-----HALQSS----RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQ 1374
Query: 748 RKT---TEKEQQTQ--EKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGS--QTDQVTT 800
+T T+ Q+T+ E+ K+KL Q+L+ ++ ++A+ K C S +T Q
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQ-----DAEEHVEAVNAK---CASLEKTKQRLQ 1426
Query: 801 SDVISKKEMAIMIEEQK--CTIQQNLEQEKDIAIKGAMKKLE---IELELKHCENITKQV 855
++V +++ I +E C ++ D + +K E ELE E+ +
Sbjct: 1427 NEV---EDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLST 1483
Query: 856 EI-AVQNAHQRWLGELPELAEYQALVKAEQKKWEEQ--------HEV-SVNKRISFAVSE 905
E+ ++NA++ L +L L ++ E EQ HE+ + K++ SE
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 906 ---AKEKWKSELENMRKNILPGK-ELEEKIHSLQKELELKNEEVPVVIR-----AELAKA 956
A E+ ++ LE+ IL + EL + + +++ K+EE+ + R E ++
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 957 RSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETEL 1016
+ + + R++++ E D + ++ N N + A A ++ + T+ +L K+T+L
Sbjct: 1604 TLDAEIRSRNDAIRLKKKMEGDLNE-MEIQLNHANRMAAEALRNY--RNTQAIL-KDTQL 1659
Query: 1017 QTCLDQSRREWTMQEAKRIQLEIYQYEEDILTV----LGVLLSDTQK-------EHISDS 1065
LD + R QE + QL + + ++L L L T++ E + S
Sbjct: 1660 H--LDDALRS---QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1714
Query: 1066 EDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDS 1125
E QLL +T L +K D + E D + RN E +K +
Sbjct: 1715 ERVQLLHTQNT------------SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKA 1762
Query: 1126 ASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTL 1182
+ AA + Q T A E K +E+ ++ D++++L+E + L
Sbjct: 1763 ITD---------AAMMAEELKKEQDTSAHLERMKKNLEQTVK---DLQHRLDEAEQL 1807
Score = 98.2 bits (243), Expect = 6e-20
Identities = 184/911 (20%), Positives = 368/911 (40%), Gaps = 133/911 (14%)
Query: 230 ENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQI----RYLNHQLVIIKDEKDGLTL 285
E S E + I++ L +AK R+LE ++ ES I + L+ +L + E GL
Sbjct: 1039 EGSLEQEKKIRMD-LERAK-RKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS 1096
Query: 286 SLRESQKLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD 345
+ + Q L +++ +L+A+I+ LE +I+A + + + K+ LE + ++L +
Sbjct: 1097 KIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 346 LHHSES-------------------LQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVT 386
+ S L+ A QHE+ L KK+ + V L + +D
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1216
Query: 387 ALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEE-------SQKQCAHLLQ 439
++ E S +K + L N E + K + K+ R+LE+ +++ L+
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGN-LEKMCRALEDQLSEIKTKEEEQQRLIN 1275
Query: 440 SGSVQ------EVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEI-------SLYES 486
+ Q E + QL + + + +A +++ ELK ++ S
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAH 1335
Query: 487 AAKLGIHPSD-------SEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSK 539
A + H D E E EL + + W+ T +Q + EE K
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 540 ---------DEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCH-------KKIEDLHQ 583
+E + + A+ L + ++ V L D++ + KK + +
Sbjct: 1396 KLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDK 1455
Query: 584 V------KKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQE 637
+ K +E E+E S +L+ + + D + LK E + LQQ+ +
Sbjct: 1456 ILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1515
Query: 638 LKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIR------E 691
L E + +L ++++ V+ + Q A++ E + +H E +I+ +
Sbjct: 1516 LTEQIAEGGKRIHEL-EKIKKQVEQEKSELQAALEEAEASL-EHEEGKILRIQLELNQVK 1573
Query: 692 SLLAKHALEKQQLFEAYERTHLQL-RSELDKLNKEVTAVQECY-LEVCREKDNLELTLRK 749
S + + EK + + +R H+++ S L+ E+ + + L+ E D E+ ++
Sbjct: 1574 SEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQL 1633
Query: 750 TTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEM 809
+ + Q + K+ Q LD +++ + D Q V + + E
Sbjct: 1634 NHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQE----DLKEQLAMVERRANLLQAE- 1688
Query: 810 AIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENIT-----KQVEIAVQNAHQ 864
IEE + T++Q E+ + IA + + E ++L H +N + K++E +
Sbjct: 1689 ---IEELRATLEQT-ERSRKIAEQELLDASE-RVQLLHTQNTSLINTKKKLETDISQIQ- 1742
Query: 865 RWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEK-WKSELENMRKNILP 923
GE+ ++ + E + EE+ + ++ A KE+ + LE M+KN
Sbjct: 1743 ---GEMEDIIQ-------EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN--- 1789
Query: 924 GKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFL 983
LE+ + LQ L+ + + ++ K + +E + E+ Q++N + + L
Sbjct: 1790 ---LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEAR-VRELEGEVESEQKRNVEAVKG-L 1844
Query: 984 DDHRNKINEVLAAAKEDFMKQKTELLLQ----------KETELQTCLDQSRREWTMQEAK 1033
H K+ E+ +ED +K L LQ K + Q + + + + +
Sbjct: 1845 RKHERKVKELTYQTEED---RKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFR 1901
Query: 1034 RIQLEIYQYEE 1044
RIQ E+ + EE
Sbjct: 1902 RIQHELEEAEE 1912
Score = 92.0 bits (227), Expect = 4e-18
Identities = 177/846 (20%), Positives = 341/846 (40%), Gaps = 171/846 (20%)
Query: 258 KLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQIKALETQIQA 317
K E+E+++ + + K+E +E ++ + + L+ Q++A +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 318 LKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSL 377
+ +Q+IK E ++ E +RA ++ E
Sbjct: 905 AEERCDQLIKTKIQLEAKIK------------EVTERAEDEEE----------------- 935
Query: 378 QKNLDATVTALKEQ-EDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAH 436
++A +TA K + ED CS LK + LE ++ EK NK+ EE
Sbjct: 936 ---INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE------- 985
Query: 437 LLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSD 496
+G + +A+L + + Q+AH + + +A ++++ +L ++ KL D
Sbjct: 986 --MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN------TLTKAKIKLEQQVDD 1037
Query: 497 SEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGS 556
EG L E + + +++ K + QE + E K + KLK + + G
Sbjct: 1038 LEGSLE---QEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGL 1094
Query: 557 NSM---KRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESST 613
S ++ L QLQ +K+ +IE+L + E+E + + K + Q
Sbjct: 1095 QSKIEDEQALGMQLQKKIKELQARIEELEE--------EIEAERASRAKAEKQ------R 1140
Query: 614 SDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQM-VQDFDHDKQEAVD 672
SD+ R+ L++ ++ L+E G + Q N+ R+ Q D +EA
Sbjct: 1141 SDLSRE-----------LEEISERLEEAGG--ATSAQIEMNKKREAEFQKMRRDLEEAT- 1186
Query: 673 RCERTYQQHHEAMKTQIRESLLAKHA---LEKQQLFEAYERTHLQLRSELDKLNKEVTAV 729
HEA +R+ KHA E + + +R +L E ++ E+ +
Sbjct: 1187 -------LQHEATAATLRK----KHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1235
Query: 730 QECYLEVCREKDNLELTLRKTTEK--EQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKK 787
V + K NLE R ++ E +T+E+ +++LI L + +++L QT +
Sbjct: 1236 ASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQ-RARL-QTESGEYSR 1293
Query: 788 TLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKH 847
LD + D + + K+ IEE K +++ ++ + +A ++
Sbjct: 1294 QLD---EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA-------HALQSSRHD 1343
Query: 848 CENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAK 907
C+ + +Q E Q A EL + +E +W ++E +R + EAK
Sbjct: 1344 CDLLREQYE-EEQEAK-------AELQRAMSKANSEVAQWRTKYETDAIQRTE-ELEEAK 1394
Query: 908 EKWKSELENMRKNILPGKELEEKIHSLQK-ELELKNEEVPVVIRAELAKAR--------- 957
+K L++ +++ + + K SL+K + L+NE ++I E A
Sbjct: 1395 KKLAQRLQDAEEHV---EAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451
Query: 958 ------SEWNKEKQEEIHRIQEQNEQD--------------YRQFLD--DHRNKINEVLA 995
+EW K+K EE H E ++++ Y + LD + + N+ L
Sbjct: 1452 NFDKILAEW-KQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ 1510
Query: 996 AAKEDFMKQKTE-------------LLLQKETELQTCLDQSRREWTMQEAK--RIQLEIY 1040
D +Q E + Q+++ELQ L+++ +E K RIQLE+
Sbjct: 1511 QEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELN 1570
Query: 1041 QYEEDI 1046
Q + ++
Sbjct: 1571 QVKSEV 1576
Score = 87.0 bits (214), Expect = 1e-16
Identities = 164/747 (21%), Positives = 316/747 (42%), Gaps = 85/747 (11%)
Query: 230 ENSAENMQIIQ-----LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIK------- 277
++ A NM+ + L+ + +A E QL + K E +R I L Q ++
Sbjct: 1233 DDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYS 1292
Query: 278 ---DEKDGLTLSLRESQKLF-QNGKEREIQLEAQIKALETQIQALKVNEEQ--MIKKSRT 331
DEKD L L ++ F Q +E + QLE +IKA AL+ + ++++
Sbjct: 1293 RQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYE 1352
Query: 332 TEMALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQ 391
E ++ Q+ + +SE Q R ++E+ + T++ EE L + L ++
Sbjct: 1353 EEQEAKAELQRAMSKANSEVAQW-RTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411
Query: 392 EDICSRLKDHVKQLERNQE--AIKLEKTEI----INKLTRS----LEESQKQC--AHLLQ 439
C+ L+ ++L+ E I +E+T ++K R+ L E +++C H
Sbjct: 1412 NAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL 1471
Query: 440 SGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDEIS-LYESAAKLGIHPSDSE 498
S +E L +L + + A+ S + + L+ E L+ EIS L E A E
Sbjct: 1472 EASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA---------E 1522
Query: 499 GELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNS 558
G I E K+V +KS++ + ++E + + E + + IL+++ E+ ++
Sbjct: 1523 GGKRIHELEKIK----KQVEQEKSELQAALEEAEASLEHEEGK-ILRIQLELNQVKSEVD 1577
Query: 559 MKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVR 618
K + + +K H +I + Q D E+ ++ D K E +++
Sbjct: 1578 RKIAEKDEEIDQMKRNHIRIVESMQSTLDA---EIRSRNDAIRLKKKM---EGDLNEME- 1630
Query: 619 DDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTY 678
+ L + ++ + + + T+ L++T L + +R Q+ ++ V+R
Sbjct: 1631 ---IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRS--QEDLKEQLAMVERRANLL 1685
Query: 679 QQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHL------QLRSELDKLNKEVTAVQEC 732
Q E ++ + ++ ++ E Q+L +A ER L L + KL +++ +Q
Sbjct: 1686 QAEIEELRATLEQTERSRKIAE-QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 733 YLEVCREKDNLELTLRKT-TEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDC 791
++ +E N E +K T+ +E KE+ + + L+QT+K ++ + LD
Sbjct: 1745 MEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR-LDE 1803
Query: 792 GSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENI 851
Q I K E + E + +Q E A+KG K E
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVE---AVKGLRKH----------ERK 1850
Query: 852 TKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVS-VN----KRISFAVSEA 906
K++ + + L + + QA VK+ +++ EE E S VN +RI + EA
Sbjct: 1851 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEA 1910
Query: 907 KEKWKSELENMRKNILPGKELEEKIHS 933
+E+ + K + +E+ KI S
Sbjct: 1911 EERADIAESQVNKLRVKSREVHTKIIS 1937
Score = 81.6 bits (200), Expect = 6e-15
Identities = 147/720 (20%), Positives = 290/720 (40%), Gaps = 137/720 (19%)
Query: 624 LKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHE 683
+ N + ++ +EL +TE K + + + M++ D Q D ++ +
Sbjct: 853 MANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEK-NDLQLQVQAEADSLADAEERCDQ 911
Query: 684 AMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNL 743
+KT+I+ K E+ E E + +L ++ KL E + E+ ++ D+L
Sbjct: 912 LIKTKIQLEAKIKEVTERA---EDEEEINAELTAKKRKLEDECS-------ELKKDIDDL 961
Query: 744 ELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAM--KKKTLDCGSQTDQVTTS 801
ELTL K +++ T+ K+K E + LD+TI + +KK L + Q T
Sbjct: 962 ELTLAKVEKEKHATENKVKNLT------EEMAGLDETIAKLTKEKKALQ---EAHQQTLD 1012
Query: 802 DVISKKEMA-------IMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQ 854
D+ ++++ I +E+Q ++ +LEQEK I + K ++E +LK + T
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072
Query: 855 VEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSEL 914
+E Q ++ + E++ Q+ ++ EQ + + K+I
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALG-----MQLQKKI--------------- 1112
Query: 915 ENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQ 974
KEL+ +I L++E+E + RA+ K RS+ ++E +E R++E
Sbjct: 1113 ----------KELQARIEELEEEIEAERAS-----RAKAEKQRSDLSRELEEISERLEEA 1157
Query: 975 NEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAKR 1034
Q NK E +F K + +L +E LQ EA
Sbjct: 1158 GGATSAQI---EMNKKREA------EFQKMRRDL---EEATLQ------------HEATA 1193
Query: 1035 IQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCI 1094
L + D + LG + + Q+ + +K+ E+ +++ K KG +
Sbjct: 1194 ATLR--KKHADSVAELGEQIDNLQR--VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNL 1249
Query: 1095 QK---AFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQAT 1151
+K A +D L + E ++R + +L+ A T G+
Sbjct: 1250 EKMCRALEDQLSEI--KTKEEEQQRLINDLTAQRARLQTESGE----------------Y 1291
Query: 1152 EAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELR 1211
+ +E + +V +L ++EEL+ + ++ SA A AL+ R
Sbjct: 1292 SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA----------HALQSSR 1341
Query: 1212 GQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQQILQ-DD 1270
CD+LR E ++ A ++ + + E A+ KY +Q+ + ++
Sbjct: 1342 HD---------CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 1271 GKEGAEKKIMNAASKL----ATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSKRN 1326
K+ +++ +A + A A L +T +++ + + T+ A+ K +RN
Sbjct: 1393 AKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRN 1452
Score = 80.9 bits (198), Expect = 1e-14
Identities = 189/999 (18%), Positives = 406/999 (40%), Gaps = 143/999 (14%)
Query: 247 AKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEA 306
AK+R+LE ++ +E ++ I L L ++ EK ++ + E +L
Sbjct: 942 AKKRKLE---DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 998
Query: 307 QIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHS----ESLQRAREQHESI 362
+ KAL+ Q + + K T A L+QQ+ DL S + ++ E+ +
Sbjct: 999 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRK 1058
Query: 363 VMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEIINK 422
+ G K +E + ++ + LK++E S L+ ++ +++A+ ++ + I +
Sbjct: 1059 LEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIE----DEQALGMQLQKKIKE 1114
Query: 423 LTRSLEESQKQC---------AHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEE 473
L +EE +++ A +S +E+ ++ +L++A A + MNK + E
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 474 LTELK---DEISLYE--SAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIV 528
+++ +E +L +AA L +DS EL ++ +++V K K S +
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID------NLQRVKQKLEKEKSEM 1228
Query: 529 QEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDE 588
+ E ++ S E + K K ++++ + L++ L + K E+ ++ D
Sbjct: 1229 KME-IDDLASNMETVSKAKGNLEKMCRA----------LEDQLSEIKTKEEEQQRLINDL 1277
Query: 589 KSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELK---ETEGKL 645
+ +T++ E + ++ S + R Q QQ +ELK E E K
Sbjct: 1278 TAQRARLQTESGEYSRQLDEKDTLVSQLSRGK--------QAFTQQIEELKRQLEEEIKA 1329
Query: 646 RNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLF 705
++ + +Q HD D Y++ EA K +++ + ++K E Q
Sbjct: 1330 KSA-------LAHALQSSRHD----CDLLREQYEEEQEA-KAELQRA-MSKANSEVAQWR 1376
Query: 706 EAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKI---- 761
YE +Q EL++ K++ + E + +L KT ++ Q E +
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV 1436
Query: 762 ------------KEKLIQQLEKEWQSKLDQT---IKAMKKKTLDCGSQTDQVTTSDVISK 806
K++ ++ EW+ K ++T ++A +K++ ++ ++ + S
Sbjct: 1437 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESL 1496
Query: 807 KEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNA---- 862
++ + E K +QQ + + +G + E+E K E +++ A++ A
Sbjct: 1497 DQLETLKRENK-NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASL 1555
Query: 863 -HQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEK-WKSELENMRKN 920
H+ +L Q + ++K E+ E+ KR + E+ + +E+ +
Sbjct: 1556 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDA 1615
Query: 921 ILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYR 980
I K++E ++ ++ +L N +R +R + +D +
Sbjct: 1616 IRLKKKMEGDLNEMEIQLNHANRMAAEALRN-----------------YRNTQAILKDTQ 1658
Query: 981 QFLDD---HRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQE------ 1031
LDD + + E LA ++++ LL + EL+ L+Q+ R + E
Sbjct: 1659 LHLDDALRSQEDLKEQLA-----MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1713
Query: 1032 AKRIQLEIYQ----------YEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKW 1081
++R+QL Q E DI + G + Q+ ++ + K+ + + + +
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEEL 1773
Query: 1082 MSVQ----YFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGP 1137
Q + E++K +++ +D L ++ A+ K ++ K A +G+
Sbjct: 1774 KKEQDTSAHLERMKKNLEQTVKD-LQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV-- 1830
Query: 1138 AAGHHAQPLALQATEAEAEENNKVVEELIEENNDMKNKL 1176
Q ++A + + KV E + D KN L
Sbjct: 1831 ---ESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNIL 1866
Score = 33.9 bits (76), Expect = 1.3
Identities = 88/421 (20%), Positives = 171/421 (40%), Gaps = 66/421 (15%)
Query: 911 KSELENMRKNILPGKELEEKIHSLQKELELK-------NEEVPVVIRAE----------- 952
+ E+ NM++ KE K + +KELE K ++ + ++AE
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERC 909
Query: 953 --LAKARSEWNKEKQEEIHRIQEQNEQD-----YRQFLDDHRNKINE-----VLAAAKED 1000
L K + + + +E R +++ E + ++ L+D +++ + L AK +
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 1001 FMKQKTELLLQKETELQTCLDQ-----SRREWTMQEAKRIQLEIYQYEEDILTVL--GVL 1053
K TE ++ TE LD+ ++ + +QEA + L+ Q EED + L +
Sbjct: 970 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI 1029
Query: 1054 LSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEW 1113
+ Q + + S +++ M +K KL+G ++ A + T+ D E
Sbjct: 1030 KLEQQVDDLEGSLEQEKKIRMDLERAK-------RKLEGDLKLAQESTM-------DIEN 1075
Query: 1114 KKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLALQATEAEAEENNKVVEELIEENNDMK 1173
K+ + E K + +G A + LQ E + + +EE IE +
Sbjct: 1076 DKQQLDEKLKKKEFEMSGL--QSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 1174 NKLEELQTLCKTPPRSLSAGAIENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESK 1233
K E+ ++ +S E +GGA I+ KK + + + ++ +
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEE------AGGA----TSAQIEMNKKREAEFQKMRRDLE 1183
Query: 1234 ERAAE-MVKAEVLRERQETARKMRKYYLICLQQILQDDGKEGAEKK--IMNAASKLATMA 1290
E + A LR++ + + LQ++ Q KE +E K I + AS + T++
Sbjct: 1184 EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 1291 K 1291
K
Sbjct: 1244 K 1244
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 101 bits (251), Expect = 7e-21
Identities = 173/891 (19%), Positives = 392/891 (43%), Gaps = 130/891 (14%)
Query: 232 SAENMQIIQLQVLNKAKERQLENLIEKLNESER---QIRYLNHQLVIIKD-----EKDGL 283
+++ Q+ + + K+ E +L+ L +L E E +I L++++ + EKD
Sbjct: 89 TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNS 148
Query: 284 TLSLRESQKLFQNGKEREIQL---------EAQIKALETQIQALKVNEEQMIKKSRTTEM 334
L + +K+FQ E+ L E + K ++ + K+N+E + +E+
Sbjct: 149 ELE-EKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSEL 207
Query: 335 ALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYE----EQVLSLQKNLDATVTALKE 390
+E + QL H E + RAR +S++ L + E E+ ++ + ++E
Sbjct: 208 LVEQGRLQLQADRHQEHI-RAR---DSLIQSLATQLELDGFERGPFSERQIKNFHKLVRE 263
Query: 391 QEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQ 450
+++ ++ + + +E +K ++ + I L + + +L S E+ ++
Sbjct: 264 RQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL-SKKQNELKNVK 322
Query: 451 FQLQQAQKAHAMSANMNKALQEELTELKDEISLYE-----SAAKLGIHPSDSEGELNIEL 505
++LQQ + S++ L +EL + + E+S E K+ + +E + +++
Sbjct: 323 YELQQLEG----SSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE-KADLDR 377
Query: 506 TESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKA----EVQRLLGSNSMKR 561
T +D ++++N + T + E ++ KDE I K+K+ E+ LLG K+
Sbjct: 378 TLRKLDQEMEQLNHHTTTRTQM--EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK 435
Query: 562 HLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRD-- 619
L L + K+ ++ + L ++ K+ S E + K + + K + SS D + D
Sbjct: 436 QLEDWLHSKSKEINQTRDRLAKLNKELASSE-QNKNHINNELKRKEEQLSSYEDKLFDVC 494
Query: 620 -------DILLLKNEIQVLQQQNQELKETEG-------KLRNTNQDLC----------NQ 655
D+ LK EI+ +Q L +L + NQ C +
Sbjct: 495 GSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 554
Query: 656 MRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQL 715
+++++ D + A D+ + T E K + R + +Q + + E+ +L
Sbjct: 555 LQEVISDLQSKLRLAPDKLKST---ESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPEL 611
Query: 716 RSELDKLNKEVTAV------QECYL-EVCREKDNLELTLRKTT--EKEQQTQEKIKEKLI 766
R++L +N+++ + QE L + E+++ ++ L T E+ Q + ++ K+
Sbjct: 612 RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIA 671
Query: 767 QQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQ 826
QQ K LD+T++ + ++ + + D V++ +++K +I++Q Q+ ++
Sbjct: 672 QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRK----LIQDQ----QEQIQH 723
Query: 827 EKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKK 886
K + +KL+I L+ + + +Q + + Q E+ + E + ++ +K
Sbjct: 724 LKSTTNELKSEKLQISTNLQRRQQLEEQT-VELSTEVQSLYREIKDAKEQVSPLETTLEK 782
Query: 887 WEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVP 946
++++ E +NK+ + + + + +L ++ KE + IH K++E
Sbjct: 783 FQQEKEELINKK-----NTSNKIAQDKLNDI-------KEKVKNIHGYMKDIE------- 823
Query: 947 VVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKT 1006
+ + ++ K+K+ E++++ Q + + H+ KINE + ++D QK
Sbjct: 824 ----NYIQDGKDDYKKQKETELNKVIAQLSE-----CEKHKEKINEDMRLMRQDIDTQKI 874
Query: 1007 E-------LLLQKETELQTCLDQSR----REWTMQEAKRIQLEIYQYEEDI 1046
+ L L+K E +++ R +E + +++ E + EE+I
Sbjct: 875 QERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENI 925
Score = 63.9 bits (154), Expect = 1e-09
Identities = 121/552 (21%), Positives = 213/552 (38%), Gaps = 95/552 (17%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQI 308
E L+ L E++ +S +Q L + LT + + Q + E +L+ I
Sbjct: 500 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 559
Query: 309 KALETQIQA----LKVNEEQMIKKSRTTE--MALESLKQQLVDLHHSE--SLQRAREQHE 360
L+++++ LK E ++ KK + + + L ++Q ++DL E L+ +
Sbjct: 560 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 619
Query: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDIC-------SRLKDHVKQLERN--QEA 411
+ L EEQ + L T+ +E +C R + +K +ER Q+A
Sbjct: 620 RDIQRLKNDIEEQ-----ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQA 674
Query: 412 IKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQ 471
KL+ ++ + + +E Q++ L S E+ + Q QQ Q H L+
Sbjct: 675 AKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQH---------LK 725
Query: 472 EELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEE 531
ELK E K ++++ +Q
Sbjct: 726 STTNELKSE----------------------------------------KLQISTNLQRR 745
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSI 591
EE + ++L EVQ L + VS L+ L+ ++ E+L K I
Sbjct: 746 QQLEEQT-----VELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 800
Query: 592 EVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQV-LQQQNQELKETEGKLRNTNQ 650
+ D EK KN + ++D K + + L + +L E E N+
Sbjct: 801 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINE 860
Query: 651 DLCNQMRQMVQDFDHDK-QEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYE 709
D MR M QD D K QE + T ++ +E +K E KQ L E +
Sbjct: 861 D----MRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE--------RKQHLKEMGQ 908
Query: 710 RTHLQLRSELDKLNKEVTAVQECY-LEVCREKDNLE--LTLRKTTEKEQ--QTQEKIKEK 764
LQ++SE KL + + ++ + L + R+K E + +K + Q +EK +E
Sbjct: 909 MQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 968
Query: 765 LIQQLEKEWQSK 776
+I E +K
Sbjct: 969 MIVMRTTELVNK 980
Score = 60.8 bits (146), Expect = 1e-08
Identities = 136/705 (19%), Positives = 280/705 (39%), Gaps = 101/705 (14%)
Query: 514 IKKVNWKKSKVTSIV--QEEDPNEELSKDEFILKLKAEV---QRLLGSNSMKRHLVSQLQ 568
I + K+ + +++ +ED N LS+ + + + E+ R + + R +
Sbjct: 2 ISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQG 61
Query: 569 NDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEI 628
+K+ +++ L Q K EK+ E+ + + E QL +S+ ++V+ +NE+
Sbjct: 62 QKVKEYQMELKYLKQYK--EKACEIRDQITSKEA---QL---TSSKEIVKS----YENEL 109
Query: 629 QVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQ 688
L+ + +E++ K+ + ++ + + + D E ++ E+ +Q E +
Sbjct: 110 DPLKNRLKEIEHNLSKIMKLDNEI-KALDSRKKQMEKDNSELEEKMEKVFQGTDEQLN-- 166
Query: 689 IRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLR 748
L H Q+ ER + EL+KLNKE + + E+ E+ L+L
Sbjct: 167 ---DLYHNH----QRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQAD 219
Query: 749 KTTEKEQQTQEKIKEKLIQQLEKEWQSK---LDQTIKAMKKKTLDCGSQTDQVTTSDVIS 805
+ E + ++ + + L QLE + + ++ IK K + Q + T++ +
Sbjct: 220 RHQE-HIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRE--RQEGEAKTANQLM 276
Query: 806 KKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELE-LKHCENITKQVEIAVQNAHQ 864
E++ Q+ +++ +D G + +E++ E L +N K V+ +Q
Sbjct: 277 ND-----FAEKETLKQKQIDEIRD-KKTGLGRIIELKSEILSKKQNELKNVKYELQQLE- 329
Query: 865 RWLGELPELAEY-QALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILP 923
G + E Q L+KAE++ + + +V +S EK
Sbjct: 330 ---GSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEK-------------- 372
Query: 924 GKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFL 983
+L+ + L +E+E N + E+ ++ +K E+I +I+ ++ + L
Sbjct: 373 -ADLDRTLRKLDQEMEQLNHHTTTRTQMEML---TKDKADKDEQIRKIKSRHSDELTSLL 428
Query: 984 DDHRNKINEVLAAAKEDFMKQKTELLLQKETEL-----QTCLDQSRREWTMQEAKRIQLE 1038
NK ED++ K++ + Q L + + + E KR + +
Sbjct: 429 GYFPNK------KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQ 482
Query: 1039 IYQYEEDILTVLG----VLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGC- 1093
+ YE+ + V G D KE I S ++ + +T Q ++ + C
Sbjct: 483 LSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCC 542
Query: 1094 --IQKAFQDTLPLLVENAD--------PEWKKRNMAELSKDSASQGTGQGDPGPAAGHHA 1143
Q+ FQ L +D P+ K +EL K + G
Sbjct: 543 PVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLG---------L 593
Query: 1144 QPLALQATEAEAEENNKVVEELIEENND---MKNKLEELQTLCKT 1185
P+ + + +E ++ +L N D +KN +EE +TL T
Sbjct: 594 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGT 638
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 101 bits (251), Expect = 7e-21
Identities = 173/891 (19%), Positives = 392/891 (43%), Gaps = 130/891 (14%)
Query: 232 SAENMQIIQLQVLNKAKERQLENLIEKLNESER---QIRYLNHQLVIIKD-----EKDGL 283
+++ Q+ + + K+ E +L+ L +L E E +I L++++ + EKD
Sbjct: 228 TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNS 287
Query: 284 TLSLRESQKLFQNGKEREIQL---------EAQIKALETQIQALKVNEEQMIKKSRTTEM 334
L + +K+FQ E+ L E + K ++ + K+N+E + +E+
Sbjct: 288 ELE-EKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSEL 346
Query: 335 ALESLKQQLVDLHHSESLQRAREQHESIVMGLTKKYE----EQVLSLQKNLDATVTALKE 390
+E + QL H E + RAR +S++ L + E E+ ++ + ++E
Sbjct: 347 LVEQGRLQLQADRHQEHI-RAR---DSLIQSLATQLELDGFERGPFSERQIKNFHKLVRE 402
Query: 391 QEDICSRLKDHVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQ 450
+++ ++ + + +E +K ++ + I L + + +L S E+ ++
Sbjct: 403 RQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL-SKKQNELKNVK 461
Query: 451 FQLQQAQKAHAMSANMNKALQEELTELKDEISLYE-----SAAKLGIHPSDSEGELNIEL 505
++LQQ + S++ L +EL + + E+S E K+ + +E + +++
Sbjct: 462 YELQQLEG----SSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE-KADLDR 516
Query: 506 TESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKA----EVQRLLGSNSMKR 561
T +D ++++N + T + E ++ KDE I K+K+ E+ LLG K+
Sbjct: 517 TLRKLDQEMEQLNHHTTTRTQM--EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK 574
Query: 562 HLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRD-- 619
L L + K+ ++ + L ++ K+ S E + K + + K + SS D + D
Sbjct: 575 QLEDWLHSKSKEINQTRDRLAKLNKELASSE-QNKNHINNELKRKEEQLSSYEDKLFDVC 633
Query: 620 -------DILLLKNEIQVLQQQNQELKETEG-------KLRNTNQDLC----------NQ 655
D+ LK EI+ +Q L +L + NQ C +
Sbjct: 634 GSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 693
Query: 656 MRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQL 715
+++++ D + A D+ + T E K + R + +Q + + E+ +L
Sbjct: 694 LQEVISDLQSKLRLAPDKLKST---ESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPEL 750
Query: 716 RSELDKLNKEVTAV------QECYL-EVCREKDNLELTLRKTT--EKEQQTQEKIKEKLI 766
R++L +N+++ + QE L + E+++ ++ L T E+ Q + ++ K+
Sbjct: 751 RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIA 810
Query: 767 QQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQ 826
QQ K LD+T++ + ++ + + D V++ +++K +I++Q Q+ ++
Sbjct: 811 QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRK----LIQDQ----QEQIQH 862
Query: 827 EKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKK 886
K + +KL+I L+ + + +Q + + Q E+ + E + ++ +K
Sbjct: 863 LKSTTNELKSEKLQISTNLQRRQQLEEQT-VELSTEVQSLYREIKDAKEQVSPLETTLEK 921
Query: 887 WEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVP 946
++++ E +NK+ + + + + +L ++ KE + IH K++E
Sbjct: 922 FQQEKEELINKK-----NTSNKIAQDKLNDI-------KEKVKNIHGYMKDIE------- 962
Query: 947 VVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKT 1006
+ + ++ K+K+ E++++ Q + + H+ KINE + ++D QK
Sbjct: 963 ----NYIQDGKDDYKKQKETELNKVIAQLSE-----CEKHKEKINEDMRLMRQDIDTQKI 1013
Query: 1007 E-------LLLQKETELQTCLDQSR----REWTMQEAKRIQLEIYQYEEDI 1046
+ L L+K E +++ R +E + +++ E + EE+I
Sbjct: 1014 QERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENI 1064
Score = 63.9 bits (154), Expect = 1e-09
Identities = 121/552 (21%), Positives = 213/552 (38%), Gaps = 95/552 (17%)
Query: 249 ERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQI 308
E L+ L E++ +S +Q L + LT + + Q + E +L+ I
Sbjct: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 698
Query: 309 KALETQIQA----LKVNEEQMIKKSRTTE--MALESLKQQLVDLHHSE--SLQRAREQHE 360
L+++++ LK E ++ KK + + + L ++Q ++DL E L+ +
Sbjct: 699 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 758
Query: 361 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDIC-------SRLKDHVKQLERN--QEA 411
+ L EEQ + L T+ +E +C R + +K +ER Q+A
Sbjct: 759 RDIQRLKNDIEEQ-----ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQA 813
Query: 412 IKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQ 471
KL+ ++ + + +E Q++ L S E+ + Q QQ Q H L+
Sbjct: 814 AKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQH---------LK 864
Query: 472 EELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEE 531
ELK E K ++++ +Q
Sbjct: 865 STTNELKSE----------------------------------------KLQISTNLQRR 884
Query: 532 DPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSI 591
EE + ++L EVQ L + VS L+ L+ ++ E+L K I
Sbjct: 885 QQLEEQT-----VELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 939
Query: 592 EVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQV-LQQQNQELKETEGKLRNTNQ 650
+ D EK KN + ++D K + + L + +L E E N+
Sbjct: 940 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINE 999
Query: 651 DLCNQMRQMVQDFDHDK-QEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYE 709
D MR M QD D K QE + T ++ +E +K E KQ L E +
Sbjct: 1000 D----MRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE--------RKQHLKEMGQ 1047
Query: 710 RTHLQLRSELDKLNKEVTAVQECY-LEVCREKDNLE--LTLRKTTEKEQ--QTQEKIKEK 764
LQ++SE KL + + ++ + L + R+K E + +K + Q +EK +E
Sbjct: 1048 MQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 1107
Query: 765 LIQQLEKEWQSK 776
+I E +K
Sbjct: 1108 MIVMRTTELVNK 1119
Score = 60.8 bits (146), Expect = 1e-08
Identities = 136/705 (19%), Positives = 280/705 (39%), Gaps = 101/705 (14%)
Query: 514 IKKVNWKKSKVTSIV--QEEDPNEELSKDEFILKLKAEV---QRLLGSNSMKRHLVSQLQ 568
I + K+ + +++ +ED N LS+ + + + E+ R + + R +
Sbjct: 141 ISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQG 200
Query: 569 NDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEI 628
+K+ +++ L Q K EK+ E+ + + E QL +S+ ++V+ +NE+
Sbjct: 201 QKVKEYQMELKYLKQYK--EKACEIRDQITSKEA---QL---TSSKEIVKS----YENEL 248
Query: 629 QVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQ 688
L+ + +E++ K+ + ++ + + + D E ++ E+ +Q E +
Sbjct: 249 DPLKNRLKEIEHNLSKIMKLDNEI-KALDSRKKQMEKDNSELEEKMEKVFQGTDEQLN-- 305
Query: 689 IRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTLR 748
L H Q+ ER + EL+KLNKE + + E+ E+ L+L
Sbjct: 306 ---DLYHNH----QRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQAD 358
Query: 749 KTTEKEQQTQEKIKEKLIQQLEKEWQSK---LDQTIKAMKKKTLDCGSQTDQVTTSDVIS 805
+ E + ++ + + L QLE + + ++ IK K + Q + T++ +
Sbjct: 359 RHQE-HIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRE--RQEGEAKTANQLM 415
Query: 806 KKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELE-LKHCENITKQVEIAVQNAHQ 864
E++ Q+ +++ +D G + +E++ E L +N K V+ +Q
Sbjct: 416 ND-----FAEKETLKQKQIDEIRD-KKTGLGRIIELKSEILSKKQNELKNVKYELQQLE- 468
Query: 865 RWLGELPELAEY-QALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILP 923
G + E Q L+KAE++ + + +V +S EK
Sbjct: 469 ---GSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEK-------------- 511
Query: 924 GKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFL 983
+L+ + L +E+E N + E+ ++ +K E+I +I+ ++ + L
Sbjct: 512 -ADLDRTLRKLDQEMEQLNHHTTTRTQMEML---TKDKADKDEQIRKIKSRHSDELTSLL 567
Query: 984 DDHRNKINEVLAAAKEDFMKQKTELLLQKETEL-----QTCLDQSRREWTMQEAKRIQLE 1038
NK ED++ K++ + Q L + + + E KR + +
Sbjct: 568 GYFPNK------KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQ 621
Query: 1039 IYQYEEDILTVLG----VLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYFEKLKGC- 1093
+ YE+ + V G D KE I S ++ + +T Q ++ + C
Sbjct: 622 LSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCC 681
Query: 1094 --IQKAFQDTLPLLVENAD--------PEWKKRNMAELSKDSASQGTGQGDPGPAAGHHA 1143
Q+ FQ L +D P+ K +EL K + G
Sbjct: 682 PVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLG---------L 732
Query: 1144 QPLALQATEAEAEENNKVVEELIEENND---MKNKLEELQTLCKT 1185
P+ + + +E ++ +L N D +KN +EE +TL T
Sbjct: 733 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGT 777
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 100 bits (250), Expect = 9e-21
Identities = 133/553 (24%), Positives = 252/553 (45%), Gaps = 78/553 (14%)
Query: 247 AKERQLENLIEKLNESERQIRYLNHQLV-------IIKDEKDGLTLSLRESQKLFQNGKE 299
A + +LE L + ++S++ I L L I++ E D L L L E + + N K
Sbjct: 456 ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML-NKKT 514
Query: 300 REIQLEAQIKALET-QIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQ 358
++IQ A+ K + +I LK + +K + +E+L++QL D S
Sbjct: 515 KQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS------- 567
Query: 359 HESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTE 418
+E+V SLQ + T TAL E+ + + +++L+ ++ + EK E
Sbjct: 568 ----------SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
Query: 419 IINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHA--MSANMNKALQEELTE 476
I+ + L++ +++ + L S +E + L + + A + + K L+ L +
Sbjct: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 677
Query: 477 LKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEE 536
K+E ES K H + E + E+++ ++ + ++T E
Sbjct: 678 KKEECLKMESQLKKA-HEAALEARASPEMSD--------RIQHLEREITRYKDESS---- 724
Query: 537 LSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDE--KSIEVE 594
K +AEV RLL ++ +++N+ D KKI +L + KD+ K ++
Sbjct: 725 --------KAQAEVDRLL-------EILKEVENEKNDKDKKIAELERQVKDQNKKVANLK 769
Query: 595 TKTDTSEKPKNQLWPES-STSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLC 653
K +K Q+ E+ D + D L++ L++++ ++E E LR + Q
Sbjct: 770 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS---LRKKDDRIEELEEALRESVQITA 826
Query: 654 NQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMK--TQIRESLLAKHALEKQQLFEAYERT 711
+ + Q+ + A E+ ++ AM+ Q ES+ AK + +Q L E + T
Sbjct: 827 EREMVLAQE-----ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAE--KET 879
Query: 712 HL-QLRSELDKLNKEVTAV-QECYLEVCREKD-NLEL----TLRKTTEKEQQTQEKIKEK 764
HL LR+E K +EV + QE L EKD N+ L + +K T++E ++ K++
Sbjct: 880 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDR 939
Query: 765 LIQQLEKEWQSKL 777
L+QQL+++ Q+++
Sbjct: 940 LVQQLKQQTQNRM 952
Score = 72.8 bits (177), Expect = 3e-12
Identities = 184/889 (20%), Positives = 357/889 (40%), Gaps = 134/889 (15%)
Query: 564 VSQLQNDLKDCHKKIEDLHQVKKDEKSIEV-ETKTDTSEKPKNQLW-PESSTSDVVRDD- 620
+ LQ LK+ ++ + L K +EV E+K +S W PE +R D
Sbjct: 151 IMDLQTQLKEVLRENDLLR------KDVEVKESKLSSSMNSIKTFWSPELKKERALRKDE 204
Query: 621 ---ILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQE------AV 671
I + K + +V+Q++NQ ++ T L QD R + Q F D
Sbjct: 205 ASKITIWKEQYRVVQEENQHMQMTIQAL----QDELRIQRDLNQLFQQDSSSRTGEPCVA 260
Query: 672 DRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQE 731
+ E +Q+ H + Q +E L + LE+ +L ++ L R E + K + +Q
Sbjct: 261 ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDE--SIKKLLEMLQS 318
Query: 732 CYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTLDC 791
L +++ E T R+ E E E L++Q EKE S L + + + D
Sbjct: 319 KGLSAKATEEDHERT-RRLAEAEMHVHHL--ESLLEQKEKE-NSMLREEMHRRFENAPD- 373
Query: 792 GSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQE-KDIAIKGAMKKLEIELELKHCE- 849
++T + T VI K+ I E+ ++LE+E + + GA+ E E E+K E
Sbjct: 374 SAKTKALQT--VIEMKDSKISSMERGL---RDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
Query: 850 --NITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHE-VSVNKRISFAVSEA 906
+ +K ++ + Q + EL Q ++ ++ + + + V K A +
Sbjct: 429 YRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 488
Query: 907 KEKWKSELENMR-----KNILPGKELEE-------------KIHSLQKELELKNEEVPVV 948
++E++ +R K + K+ ++ +IH L+ L++K +V V+
Sbjct: 489 AAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVL 548
Query: 949 IRAELAKARSEWNKEKQEEIHRIQEQNEQDYRQFLD-DHRNKINEVLAAAKEDFMKQKTE 1007
Q++I +QEQ +Q R K + + + E
Sbjct: 549 ----------------QKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
Query: 1008 LLLQKETELQTCLDQSRREWTMQEAKRIQLEIYQYE-EDILTVLGVLLSDTQKEHISDSE 1066
L +KE ++ +Q R+ + K+ +++ Y+ + +D+ + +L D ++ S
Sbjct: 593 ALAEKERTIERLKEQRDRD---EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS--- 646
Query: 1067 DKQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSA 1126
LL++ SS S G + + TL + +E E K ++L K A
Sbjct: 647 ---LLDLKEHASSLASS--------GLKKDSRLKTLEIALEQKKEECLKME-SQLKK--A 692
Query: 1127 SQGTGQGDPGPAAGHHAQPLALQAT---------EAEAEENNKVVEELIEENNDMKNKLE 1177
+ + P Q L + T +AE + ++++E+ E ND K+
Sbjct: 693 HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752
Query: 1178 ELQTLCKTPPRSL-SAGAIENACLPCSGGALEELR---------GQYIKAVKKIKCDMLR 1227
EL+ K + + + E S LEE R Q ++ + K D +
Sbjct: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812
Query: 1228 YIQESKERAAEM-VKAEVLRERQETAR----KMRKYYLICLQQILQDDGKEGAEKKIMNA 1282
++E+ + ++ + E++ ++E+AR K + L+ ++++ Q+ E + K+ +
Sbjct: 813 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQE--LESMKAKLSST 870
Query: 1283 ASKLATMAKLLETPISS--KSQSKTTQSALPLTSEMLIAVKKSKRNDVNQKIPCCIESKS 1340
LA ET +++ + K + L + E L+A K D N + SK
Sbjct: 871 QQSLAEK----ETHLTNLRAERRKHLEEVLEMKQEALLAAISEK--DANIALLELSSSKK 924
Query: 1341 NSVNTITRTLCE-----QAPKRRAACNLQRLLENSEHQSIKHVGSKETH 1384
+ + E Q K++ ++ + +N E K S +T+
Sbjct: 925 KTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 973
Score = 48.9 bits (115), Expect = 4e-05
Identities = 54/270 (20%), Positives = 117/270 (43%), Gaps = 34/270 (12%)
Query: 196 KPYQSSAQNNGSPAQEITGSDTFEGLQQQFLG-ANENSAENMQIIQLQVLNKAKERQLEN 254
K ++++ + SP SD + L+++ +E+S ++ +L + K E + +
Sbjct: 691 KAHEAALEARASPEM----SDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 746
Query: 255 LIEKLNESERQIRYLNHQLVIIKD----EKDGLTLSLRESQKLFQNGKEREIQLEAQIKA 310
+K+ E ERQ++ N ++ +K EK L E+++ N + QL+ ++
Sbjct: 747 KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 806
Query: 311 LETQIQALK---------VNEEQMI----KKSRTTE--------MALESLKQQL----VD 345
+ +I+ L+ E +M+ + +RT MA+E +KQ+L
Sbjct: 807 KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 866
Query: 346 LHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQL 405
L ++ +E H + + +K+ E+VL +++ + K+ L K+
Sbjct: 867 LSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT 926
Query: 406 ERNQEAIKLEKTEIINKLTRSLEESQKQCA 435
+ A+K EK ++ +L + + K A
Sbjct: 927 QEEVAALKREKDRLVQQLKQQTQNRMKLMA 956
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 100 bits (250), Expect = 9e-21
Identities = 182/742 (24%), Positives = 315/742 (42%), Gaps = 89/742 (11%)
Query: 232 SAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQ 291
S +N + ++Q E L N ++ E E++ + +N +L E + ++LR+S
Sbjct: 436 SRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEE-EITLRKSV 494
Query: 292 KLFQNGKEREIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSES 351
+ ERE L Q K E Q +A + K R E + SLK QL DL
Sbjct: 495 ESALRQLEREKAL-LQHKNAEYQRKA-----DHEADKKRNLENDVNSLKDQLEDL----- 543
Query: 352 LQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLK-------DHVKQ 404
+ R Q+ I E+V LQ+ LD T L+ + D +RL+ ++Q
Sbjct: 544 --KKRNQNSQI-------STEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQ 594
Query: 405 LERNQE------------AIKLEKTEIINKLTRSLEESQKQCAH--LLQSGSVQEVAQLQ 450
LE N +KLEK E IN L +LE ++ H + + + L+
Sbjct: 595 LESNNRDLQDKNCLLETAKLKLEK-EFIN-LQSALESERRDRTHGSEIINDLQGRICGLE 652
Query: 451 FQLQQAQKAHAMSANMNKALQEELTELKDEISLYE---SAAKLGIHPSDSEGELNIELTE 507
L+ + A + LQE T+L+ E S E + I S + E + T+
Sbjct: 653 EDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATK 712
Query: 508 SYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILK---LKAEVQRLLGSNSMKRHLV 564
+ + K+K+ ++E ++ +L+ LK +V+ LL + KR
Sbjct: 713 ARLA--------DKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLL-LEAEKR--C 761
Query: 565 SQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLL 624
S L DLK +KI +L + +KD + +V T E+ + + + + L
Sbjct: 762 SLLDCDLKQSQQKINELLK-QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTL 820
Query: 625 KNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEA 684
K + L+Q+N L E + L N +L R+ QD D +E D+ E Q
Sbjct: 821 KMSEKQLKQENNHLMEMKMNLEKQNAEL----RKERQDADGQMKELQDQLE-AEQYFSTL 875
Query: 685 MKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLE 744
KTQ+RE L + EK +L + ++ +L+ E D L + LE+ K + E
Sbjct: 876 YKTQVRE--LKEECEEKTKLGKELQQKKQELQDERDSLAAQ--------LEITLTKADSE 925
Query: 745 LTLRKTTEKEQQTQEKIKEKLIQQLE-KEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSDV 803
R E++ E KEK++++LE KE ++ Q + K T+ +T++ TSDV
Sbjct: 926 QLARSIAEEQYSDLE--KEKIMKELEIKEMMARHKQEL-TEKDATIASLEETNRTLTSDV 982
Query: 804 ISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAVQNAH 863
+ + + +Q+ L + KD I A K + E +L + Q AV
Sbjct: 983 ANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQ---AVNKLA 1039
Query: 864 QRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELENMRKNILP 923
+ + P V+ ++K+ + H ++R +++ K++ EL M+ I
Sbjct: 1040 EIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREK--LTQQMIKYQKELNEMQAQI-- 1095
Query: 924 GKELEEKIHSLQKELELKNEEV 945
+E + +I LQ L+ K+ ++
Sbjct: 1096 AEESQIRI-ELQMTLDSKDSDI 1116
Score = 70.9 bits (172), Expect = 1e-11
Identities = 136/683 (19%), Positives = 290/683 (42%), Gaps = 86/683 (12%)
Query: 630 VLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQI 689
+ ++N+E +E + KL + L N+M Q ++ + + R E+T ++ E + +
Sbjct: 434 IQSRKNEESQEIQKKLYTLEEHLSNEM-QAKEELEQKCKSVNTRLEKTAKELEE--EITL 490
Query: 690 RESL-LAKHALEKQQLFEAYERTHLQLRS--ELDK---LNKEVTAVQECYLEVCREKDNL 743
R+S+ A LE+++ ++ Q ++ E DK L +V ++++ ++ + N
Sbjct: 491 RKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNS 550
Query: 744 ELTLRKTTEKEQQTQEKIKE-KLIQQLEKEWQSKLDQTIKAMKKKTLDCGSQTDQVTTSD 802
++ +TEK Q Q ++ E + + E + ++L +T K+ S + +
Sbjct: 551 QI----STEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKN 606
Query: 803 VISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGA--MKKLE-----IELELKHCENITKQV 855
+ + + +E++ +Q LE E+ G+ + L+ +E +LK+ + + +V
Sbjct: 607 CL-LETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKV 665
Query: 856 EIAVQNAHQRWLGELPELAE------YQALVKAEQKKWEEQHEVSVNKRIS--FAVSEAK 907
E+ + +R+ E + YQ V + + EE + R++ + E+
Sbjct: 666 ELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESI 725
Query: 908 EKWKSE-LENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRA------ELAKARSEW 960
E+ KSE ++ M K +L + L++K+ +L E E + + ++ EL K +
Sbjct: 726 EEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVL 785
Query: 961 NKEKQEEIHRIQEQNEQD--YRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQT 1018
N++ + +I+++ ++ + L ++N + + K+ +KQ+ L++ + L+
Sbjct: 786 NEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQ--LKQENNHLMEMKMNLEK 843
Query: 1019 CLDQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCS 1078
+ R+E Q+A E+ E +++ S Q+ E+ C
Sbjct: 844 QNAELRKE--RQDADGQMKELQDQLE-------------AEQYFSTLYKTQVRELKEECE 888
Query: 1079 SKWMSVQYFEKLKGCIQ---KAFQDTLPLLVENADPEWKKRNMAE-----LSKDSASQGT 1130
K + ++ K +Q + L + + AD E R++AE L K+ +
Sbjct: 889 EKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKEL 948
Query: 1131 GQGDPGPAAGHHAQPLALQATEAEAEENNKV----VEELIEENNDMKNKLEELQ-TLCKT 1185
+ A H + AT A EE N+ V L E ++ NKL+++Q L +
Sbjct: 949 EIKE--MMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRL 1006
Query: 1186 PPRSLSAGAI----------ENACLPCSGGALEELRGQYIKAVKKIKCDMLRYIQESKER 1235
+SA AI E + L E+ + + D+ R KE+
Sbjct: 1007 KDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRR-----KEK 1061
Query: 1236 AAEMVKAEVLRERQETARKMRKY 1258
+ E+ ER++ ++M KY
Sbjct: 1062 ENRKLHMELKSEREKLTQQMIKY 1084
Score = 68.2 bits (165), Expect = 6e-11
Identities = 142/683 (20%), Positives = 275/683 (40%), Gaps = 87/683 (12%)
Query: 683 EAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDN 742
E Q R++ ++ +K E + +Q + EL++ K V LE ++
Sbjct: 430 ETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNT----RLEKTAKELE 485
Query: 743 LELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQTIKAMKKKTL--DCGSQTDQVTT 800
E+TLRK+ E + E+ K L+Q E+Q K D +A KK+ L D S DQ+
Sbjct: 486 EEITLRKSVESALRQLEREKA-LLQHKNAEYQRKADH--EADKKRNLENDVNSLKDQL-- 540
Query: 801 SDVISKKEMAIMIEEQKCTIQQNLEQ-------EKDIAIKGAMKKLEIELELKHCENITK 853
D+ + + + + E+ +Q+ L++ E D A + + E +++ E+ +
Sbjct: 541 EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR 600
Query: 854 QVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSE 913
++ L E Q+ +++E++ + H + + + +E K+
Sbjct: 601 DLQDKNCLLETAKLKLEKEFINLQSALESERR--DRTHGSEIINDLQGRICGLEEDLKNG 658
Query: 914 LENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEWNKEKQEEIHRIQE 973
+ K L ++L+E+ L+KE N E+ + + ++ + + E++E H+ +
Sbjct: 659 KILLAKVELEKRQLQERFTDLEKEKS--NMEIDMTYQLKVIQQ----SLEQEEAEHKATK 712
Query: 974 QNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCLDQSRREWTMQEAK 1033
D +NKI E + AK + MK+ + LL++ T L Q ++ K
Sbjct: 713 ARLAD--------KNKIYESIEEAKSEAMKEMEKKLLEERT-----LKQKVENLLLEAEK 759
Query: 1034 RIQL------EIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSKWMSVQYF 1087
R L + Q ++L VL D + + ++ Q + T + M Q
Sbjct: 760 RCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQ--KRCLTQNDLKMQTQQV 817
Query: 1088 EKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAGHHAQPLA 1147
LK ++ Q+ L+ + E + + + +D+ Q D A + +
Sbjct: 818 NTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYK 877
Query: 1148 LQATE--AEAEENNKVVEELIEENNDMKNKLEELQ-----TLCKTPPRSLSAGAIENACL 1200
Q E E EE K+ +EL ++ +++++ + L TL K L+ E
Sbjct: 878 TQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEE--- 934
Query: 1201 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVK------------AEVLRER 1248
+L + I +IK M R+ QE E+ A + A + E+
Sbjct: 935 -----QYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEK 989
Query: 1249 QETARKMRKYYLICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQS 1308
+E K++ +Q+ +++I AA K A K L T + K+Q+ +
Sbjct: 990 EELNNKLKD---------VQEQLSRLKDEEISAAAIK-AQFEKQLLTERTLKTQAVNKLA 1039
Query: 1309 ALPLTSEMLIAVKKSKRNDVNQK 1331
+ E VK+ DV +K
Sbjct: 1040 EIMNRKE---PVKRGNDTDVRRK 1059
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 100 bits (249), Expect = 1e-20
Identities = 210/1017 (20%), Positives = 422/1017 (41%), Gaps = 128/1017 (12%)
Query: 236 MQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ 295
+Q+ + + +A+ ++L+ + E +S R++ L ++ +++E+ L LR +L
Sbjct: 870 LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 929
Query: 296 NGKEREIQLEAQIKALETQIQAL--KVNEEQMIKKSRTTEMALESLKQQLVDLH-HSESL 352
+E +L A+ + LE + L +V EE+ + TE + L+Q + +L H E+
Sbjct: 930 EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEK--KRLQQHIQELEAHLEAE 987
Query: 353 QRARE--QHESIVM-GLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQ 409
+ AR+ Q E + KK+EE +L L+ D KE++ + RL + Q +
Sbjct: 988 EGARQKLQLEKVTTEAKMKKFEEDLLLLE---DQNSKLSKERKLLEDRLAEFSSQAAEEE 1044
Query: 410 EAIK-LEKTEIINKLTRS-------LEESQKQCAHLLQSGSVQEVAQLQFQL----QQAQ 457
E +K L K + + T + EE +Q L+ E ++LQ Q+ Q+A+
Sbjct: 1045 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1104
Query: 458 KAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKV 517
+ A + LQ L +DE K S E L E+ DL ++V
Sbjct: 1105 ELRAQLGRKEEELQAALARAEDEGGARAQLLK-------SLREAQAALAEAQEDLESERV 1157
Query: 518 NWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKK 577
K++ Q D EEL L+ E++ L S + ++ L S+ + ++ + K
Sbjct: 1158 ARTKAEK----QRRDLGEELEA------LRGELEDTLDSTNAQQELRSKREQEVTELKKT 1207
Query: 578 IED---LHQVKKDEKSI-------EVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNE 627
+E+ +H+ E E+ + + + + K W ++ + + ++ L+ E
Sbjct: 1208 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA-WEKTRLA--LEAEVSELRAE 1264
Query: 628 IQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQ------- 680
+ LQ QE ++ +L Q++ + D + + EA ++ +R +
Sbjct: 1265 LSSLQTARQEGEQRRRRLELQLQEVQGR----AGDGERARAEAAEKLQRAQAELENVSGA 1320
Query: 681 --HHEAMKTQIRESLLAKHAL--EKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLE- 735
E+ ++ + L + A + Q+L + R L L S + + E ++E E
Sbjct: 1321 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1380
Query: 736 -VCREKDNLELTL--------RKTTEKEQ---QTQEKIKEKLIQQLEKEWQ--SKLDQTI 781
RE+ EL R+ E+E + E+ + + ++ E Q ++ +T+
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1440
Query: 782 KAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEI 841
+++ + D T D+ ++++ +E+++ Q L +EK ++ ++
Sbjct: 1441 DRLERGRRRLQQELDDATM-DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1499
Query: 842 ELELKHCE----NITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNK 897
E E + E ++T+ +E + + AE +AL+ ++ + HE+
Sbjct: 1500 EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1559
Query: 898 RISFAVSEAKEKWKSELENMRKNILPGK-ELEEKIHSL--QKELELKN-EEVPVVIRAEL 953
R++ + +ELE+ K LE + +L Q E +L+ +E R +L
Sbjct: 1560 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQL 1619
Query: 954 AKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAA---KEDFMKQKTELLL 1010
AK + E+ EE R Q R+ L+ ++ +A+A KE+ +KQ ++
Sbjct: 1620 AKQLRDAEVERDEE--RKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA 1677
Query: 1011 QKETELQTCLDQSR--REWTMQEAKRIQLEIYQYEEDILTVLGVLL-SDTQKEHISDSED 1067
Q + EL ++++R RE + + + + E ++L + L SD + D
Sbjct: 1678 QMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRD 1736
Query: 1068 KQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDT----------------LPLLVENADP 1111
+ E+ + SK ++ +L+G + + ++ L L VE+
Sbjct: 1737 EMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT 1796
Query: 1112 EWKKRNMAELSKDSASQGT-----------GQGDPGPAAGHHAQPLALQATEAEAEE 1157
E +S Q G+ D G A H AL++ A+AEE
Sbjct: 1797 ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEE 1853
Score = 87.0 bits (214), Expect = 1e-16
Identities = 177/861 (20%), Positives = 353/861 (40%), Gaps = 155/861 (18%)
Query: 228 ANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSL 287
+++ + E ++ L L E + ++ ++L + E+ +L +K DG + L
Sbjct: 1037 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKG----RQELEKLKRRLDGESSEL 1092
Query: 288 RESQKLFQNGKEREIQLEAQIKALETQIQALKVNEE-------QMIKKSRTTEMALESLK 340
+E Q +R +L AQ+ E ++QA E Q++K R + AL +
Sbjct: 1093 QEQMVEQQ---QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149
Query: 341 QQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKD 400
+ L SE + R + + + +G E++ +L+ L+ T+ + Q+++ S+ +
Sbjct: 1150 EDL----ESERVARTKAEKQRRDLG------EELEALRGELEDTLDSTNAQQELRSKREQ 1199
Query: 401 HVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAH 460
V +L++ E E+T I + L + Q + +L QL+QA++
Sbjct: 1200 EVTELKKTLE----EETRIHEAAVQELRQRHGQA-----------LGELAEQLEQARRGK 1244
Query: 461 AMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWK 520
AL+ E++EL+ E+S ++A + G L ++L E
Sbjct: 1245 GAWEKTRLALEAEVSELRAELSSLQTARQEG---EQRRRRLELQLQE------------- 1288
Query: 521 KSKVTSIVQEEDPNEELSKDEFILKL---KAEVQRLLGSNSMKRHLVSQLQNDLKDCHKK 577
VQ + E ++ E KL +AE++ + G+ + +L +L +
Sbjct: 1289 -------VQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341
Query: 578 IEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQE 637
+ D ++ ++E ++ + + ++ E L++Q +E
Sbjct: 1342 LHDAQELLQEETRAKL----------------------ALGSRVRAMEAEAAGLREQLEE 1379
Query: 638 ---LKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLL 694
+E G+ T Q ++ R+ Q+ + EA + R + EA L
Sbjct: 1380 EAAARERAGRELQTAQAQLSEWRRR-QEEEAGALEAGEEARRRAAREAEA---------L 1429
Query: 695 AKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTL------- 747
+ EK + + ER +L+ ELD ++ ++ + +++ + L
Sbjct: 1430 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1489
Query: 748 ------RKTTEKEQQTQEKIKEKLIQQLEKEWQSK--LDQTIKAMKKKTLDCGSQTDQVT 799
R+ E E + +E L + LE+E +++ L++ +A++ + S D V
Sbjct: 1490 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1549
Query: 800 TSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAV 859
S + + E A + EQ D+ + E+E EL E+ ++E+ V
Sbjct: 1550 KS--VHELERACRVAEQAA---------NDL----RAQVTELEDELTAAEDAKLRLEVTV 1594
Query: 860 Q---NAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELEN 916
Q H+R L E E + A+Q + E K+ + AV+ A++K + ELE
Sbjct: 1595 QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA-ARKKLEGELEE 1653
Query: 917 MRKNIL-PGKELEEKIHSLQ------KELELKNEEVPVVIRAELAKARSEWNKE---KQE 966
++ + G+ EE + L+ KEL + EE R E+ E K +
Sbjct: 1654 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR-TSREEIFSQNRESEKRLKGLEA 1712
Query: 967 EIHRIQEQ---NEQDYRQFLDDHRNKINEVLAA--AKEDFMKQKTEL---LLQKETELQT 1018
E+ R+QE+ +++ RQ D +EV +K +++K +L L Q E EL+
Sbjct: 1713 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1772
Query: 1019 CLDQSRREWTMQEAKRIQLEI 1039
+QS E +++ L++
Sbjct: 1773 --EQSNSELLNDRYRKLLLQV 1791
Score = 66.2 bits (160), Expect = 2e-10
Identities = 98/510 (19%), Positives = 214/510 (41%), Gaps = 67/510 (13%)
Query: 248 KERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQ 307
++RQL + +EK Q+ + +EK + ++ E ++ G+ERE + +
Sbjct: 1463 QQRQLVSTLEKKQRKFDQL---------LAEEKAAVLRAVEERERAEAEGREREARALSL 1513
Query: 308 IKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD----LHHSESLQRAREQHESIV 363
+ALE + +A E++ +++R LE+L D +H E R EQ + +
Sbjct: 1514 TRALEEEQEA----REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDL 1569
Query: 364 MGLTKKYEEQVLSLQK---NLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEI- 419
+ E+++ + + L+ TV ALK Q + + +D + R Q A +L E+
Sbjct: 1570 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVE 1629
Query: 420 --------------INKLTRSLEESQKQCAHLLQ--SGSVQEVAQLQFQLQQ-------- 455
KL LEE + Q A Q +V+++ ++Q Q+++
Sbjct: 1630 RDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET 1689
Query: 456 -AQKAHAMSANMN-----KALQEELTELKDEISLYESAAKLGIHPSDSEGE--LNIELTE 507
+ S N K L+ E+ L++E++ + A + D + N L++
Sbjct: 1690 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSK 1749
Query: 508 SYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQL 567
+ + +++ + ++ ++EE N EL D + KL +V+ L S +R ++
Sbjct: 1750 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKA 1808
Query: 568 QNDLKDCHKKIEDLH-QVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLK- 625
++ + ++I++L ++ +++ K + E R+ IL K
Sbjct: 1809 ESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKL 1868
Query: 626 -----NEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAV------DRC 674
++ + Q +E + +LR+ + +++Q+ + + ++EA R
Sbjct: 1869 VRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1928
Query: 675 ERTYQQHHEAMKTQIRESLLAKHALEKQQL 704
+R + E+ ++ RE ++ L + L
Sbjct: 1929 QRELEDVTESAESMNREVTTLRNRLRRGPL 1958
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 100 bits (249), Expect = 1e-20
Identities = 210/1017 (20%), Positives = 422/1017 (41%), Gaps = 128/1017 (12%)
Query: 236 MQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQ 295
+Q+ + + +A+ ++L+ + E +S R++ L ++ +++E+ L LR +L
Sbjct: 862 LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 921
Query: 296 NGKEREIQLEAQIKALETQIQAL--KVNEEQMIKKSRTTEMALESLKQQLVDLH-HSESL 352
+E +L A+ + LE + L +V EE+ + TE + L+Q + +L H E+
Sbjct: 922 EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEK--KRLQQHIQELEAHLEAE 979
Query: 353 QRARE--QHESIVM-GLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQ 409
+ AR+ Q E + KK+EE +L L+ D KE++ + RL + Q +
Sbjct: 980 EGARQKLQLEKVTTEAKMKKFEEDLLLLE---DQNSKLSKERKLLEDRLAEFSSQAAEEE 1036
Query: 410 EAIK-LEKTEIINKLTRS-------LEESQKQCAHLLQSGSVQEVAQLQFQL----QQAQ 457
E +K L K + + T + EE +Q L+ E ++LQ Q+ Q+A+
Sbjct: 1037 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAE 1096
Query: 458 KAHAMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKV 517
+ A + LQ L +DE K S E L E+ DL ++V
Sbjct: 1097 ELRAQLGRKEEELQAALARAEDEGGARAQLLK-------SLREAQAALAEAQEDLESERV 1149
Query: 518 NWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKK 577
K++ Q D EEL L+ E++ L S + ++ L S+ + ++ + K
Sbjct: 1150 ARTKAEK----QRRDLGEELEA------LRGELEDTLDSTNAQQELRSKREQEVTELKKT 1199
Query: 578 IED---LHQVKKDEKSI-------EVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNE 627
+E+ +H+ E E+ + + + + K W ++ + + ++ L+ E
Sbjct: 1200 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA-WEKTRLA--LEAEVSELRAE 1256
Query: 628 IQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQ------- 680
+ LQ QE ++ +L Q++ + D + + EA ++ +R +
Sbjct: 1257 LSSLQTARQEGEQRRRRLELQLQEVQGR----AGDGERARAEAAEKLQRAQAELENVSGA 1312
Query: 681 --HHEAMKTQIRESLLAKHAL--EKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLE- 735
E+ ++ + L + A + Q+L + R L L S + + E ++E E
Sbjct: 1313 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1372
Query: 736 -VCREKDNLELTL--------RKTTEKEQ---QTQEKIKEKLIQQLEKEWQ--SKLDQTI 781
RE+ EL R+ E+E + E+ + + ++ E Q ++ +T+
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1432
Query: 782 KAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEI 841
+++ + D T D+ ++++ +E+++ Q L +EK ++ ++
Sbjct: 1433 DRLERGRRRLQQELDDATM-DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1491
Query: 842 ELELKHCE----NITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNK 897
E E + E ++T+ +E + + AE +AL+ ++ + HE+
Sbjct: 1492 EAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERAC 1551
Query: 898 RISFAVSEAKEKWKSELENMRKNILPGK-ELEEKIHSL--QKELELKN-EEVPVVIRAEL 953
R++ + +ELE+ K LE + +L Q E +L+ +E R +L
Sbjct: 1552 RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQL 1611
Query: 954 AKARSEWNKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAA---KEDFMKQKTELLL 1010
AK + E+ EE R Q R+ L+ ++ +A+A KE+ +KQ ++
Sbjct: 1612 AKQLRDAEVERDEE--RKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA 1669
Query: 1011 QKETELQTCLDQSR--REWTMQEAKRIQLEIYQYEEDILTVLGVLL-SDTQKEHISDSED 1067
Q + EL ++++R RE + + + + E ++L + L SD + D
Sbjct: 1670 QMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRD 1728
Query: 1068 KQLLEIMSTCSSKWMSVQYFEKLKGCIQKAFQDT----------------LPLLVENADP 1111
+ E+ + SK ++ +L+G + + ++ L L VE+
Sbjct: 1729 EMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTT 1788
Query: 1112 EWKKRNMAELSKDSASQGT-----------GQGDPGPAAGHHAQPLALQATEAEAEE 1157
E +S Q G+ D G A H AL++ A+AEE
Sbjct: 1789 ELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEE 1845
Score = 87.0 bits (214), Expect = 1e-16
Identities = 177/861 (20%), Positives = 353/861 (40%), Gaps = 155/861 (18%)
Query: 228 ANENSAENMQIIQLQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSL 287
+++ + E ++ L L E + ++ ++L + E+ +L +K DG + L
Sbjct: 1029 SSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKG----RQELEKLKRRLDGESSEL 1084
Query: 288 RESQKLFQNGKEREIQLEAQIKALETQIQALKVNEE-------QMIKKSRTTEMALESLK 340
+E Q +R +L AQ+ E ++QA E Q++K R + AL +
Sbjct: 1085 QEQMVEQQ---QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141
Query: 341 QQLVDLHHSESLQRAREQHESIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKD 400
+ L SE + R + + + +G E++ +L+ L+ T+ + Q+++ S+ +
Sbjct: 1142 EDL----ESERVARTKAEKQRRDLG------EELEALRGELEDTLDSTNAQQELRSKREQ 1191
Query: 401 HVKQLERNQEAIKLEKTEIINKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAH 460
V +L++ E E+T I + L + Q + +L QL+QA++
Sbjct: 1192 EVTELKKTLE----EETRIHEAAVQELRQRHGQA-----------LGELAEQLEQARRGK 1236
Query: 461 AMSANMNKALQEELTELKDEISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWK 520
AL+ E++EL+ E+S ++A + G L ++L E
Sbjct: 1237 GAWEKTRLALEAEVSELRAELSSLQTARQEG---EQRRRRLELQLQE------------- 1280
Query: 521 KSKVTSIVQEEDPNEELSKDEFILKL---KAEVQRLLGSNSMKRHLVSQLQNDLKDCHKK 577
VQ + E ++ E KL +AE++ + G+ + +L +L +
Sbjct: 1281 -------VQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333
Query: 578 IEDLHQVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQE 637
+ D ++ ++E ++ + + ++ E L++Q +E
Sbjct: 1334 LHDAQELLQEETRAKL----------------------ALGSRVRAMEAEAAGLREQLEE 1371
Query: 638 ---LKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLL 694
+E G+ T Q ++ R+ Q+ + EA + R + EA L
Sbjct: 1372 EAAARERAGRELQTAQAQLSEWRRR-QEEEAGALEAGEEARRRAAREAEA---------L 1421
Query: 695 AKHALEKQQLFEAYERTHLQLRSELDKLNKEVTAVQECYLEVCREKDNLELTL------- 747
+ EK + + ER +L+ ELD ++ ++ + +++ + L
Sbjct: 1422 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1481
Query: 748 ------RKTTEKEQQTQEKIKEKLIQQLEKEWQSK--LDQTIKAMKKKTLDCGSQTDQVT 799
R+ E E + +E L + LE+E +++ L++ +A++ + S D V
Sbjct: 1482 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1541
Query: 800 TSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLEIELELKHCENITKQVEIAV 859
S + + E A + EQ D+ + E+E EL E+ ++E+ V
Sbjct: 1542 KS--VHELERACRVAEQAA---------NDL----RAQVTELEDELTAAEDAKLRLEVTV 1586
Query: 860 Q---NAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRISFAVSEAKEKWKSELEN 916
Q H+R L E E + A+Q + E K+ + AV+ A++K + ELE
Sbjct: 1587 QALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA-ARKKLEGELEE 1645
Query: 917 MRKNIL-PGKELEEKIHSLQ------KELELKNEEVPVVIRAELAKARSEWNKE---KQE 966
++ + G+ EE + L+ KEL + EE R E+ E K +
Sbjct: 1646 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR-TSREEIFSQNRESEKRLKGLEA 1704
Query: 967 EIHRIQEQ---NEQDYRQFLDDHRNKINEVLAA--AKEDFMKQKTEL---LLQKETELQT 1018
E+ R+QE+ +++ RQ D +EV +K +++K +L L Q E EL+
Sbjct: 1705 EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1764
Query: 1019 CLDQSRREWTMQEAKRIQLEI 1039
+QS E +++ L++
Sbjct: 1765 --EQSNSELLNDRYRKLLLQV 1783
Score = 66.2 bits (160), Expect = 2e-10
Identities = 98/510 (19%), Positives = 214/510 (41%), Gaps = 67/510 (13%)
Query: 248 KERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKEREIQLEAQ 307
++RQL + +EK Q+ + +EK + ++ E ++ G+ERE + +
Sbjct: 1455 QQRQLVSTLEKKQRKFDQL---------LAEEKAAVLRAVEERERAEAEGREREARALSL 1505
Query: 308 IKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVD----LHHSESLQRAREQHESIV 363
+ALE + +A E++ +++R LE+L D +H E R EQ + +
Sbjct: 1506 TRALEEEQEA----REELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDL 1561
Query: 364 MGLTKKYEEQVLSLQK---NLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEI- 419
+ E+++ + + L+ TV ALK Q + + +D + R Q A +L E+
Sbjct: 1562 RAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVE 1621
Query: 420 --------------INKLTRSLEESQKQCAHLLQ--SGSVQEVAQLQFQLQQ-------- 455
KL LEE + Q A Q +V+++ ++Q Q+++
Sbjct: 1622 RDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET 1681
Query: 456 -AQKAHAMSANMN-----KALQEELTELKDEISLYESAAKLGIHPSDSEGE--LNIELTE 507
+ S N K L+ E+ L++E++ + A + D + N L++
Sbjct: 1682 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSK 1741
Query: 508 SYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKDEFILKLKAEVQRLLGSNSMKRHLVSQL 567
+ + +++ + ++ ++EE N EL D + KL +V+ L S +R ++
Sbjct: 1742 AAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRY-RKLLLQVESLTTELSAERSFSAKA 1800
Query: 568 QNDLKDCHKKIEDLH-QVKKDEKSIEVETKTDTSEKPKNQLWPESSTSDVVRDDILLLK- 625
++ + ++I++L ++ +++ K + E R+ IL K
Sbjct: 1801 ESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKL 1860
Query: 626 -----NEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQEAV------DRC 674
++ + Q +E + +LR+ + +++Q+ + + ++EA R
Sbjct: 1861 VRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1920
Query: 675 ERTYQQHHEAMKTQIRESLLAKHALEKQQL 704
+R + E+ ++ RE ++ L + L
Sbjct: 1921 QRELEDVTESAESMNREVTTLRNRLRRGPL 1950
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,482,205
Number of Sequences: 37866
Number of extensions: 3005234
Number of successful extensions: 22177
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 1158
Number of HSP's that attempted gapping in prelim test: 13095
Number of HSP's gapped (non-prelim): 5845
length of query: 1654
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1538
effective length of database: 13,855,062
effective search space: 21309085356
effective search space used: 21309085356
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.