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Search of human proteins with 156546890
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
(1192 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 2317 0.0
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 1000 0.0
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 998 0.0
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 998 0.0
gi|38570149 WWC family member 3 [Homo sapiens] 763 0.0
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 91 7e-18
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 91 7e-18
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 88 4e-17
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 87 7e-17
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 87 7e-17
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 87 7e-17
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 69 3e-11
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 67 1e-10
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 66 2e-10
gi|11141889 WW45 protein [Homo sapiens] 65 3e-10
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 65 4e-10
gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo ... 65 4e-10
gi|114520609 neural precursor cell expressed, developmentally do... 64 9e-10
gi|114520607 neural precursor cell expressed, developmentally do... 64 9e-10
gi|222352183 neural precursor cell expressed, developmentally do... 63 2e-09
gi|21361472 neural precursor cell expressed, developmentally dow... 63 2e-09
gi|222352094 neural precursor cell expressed, developmentally do... 63 2e-09
gi|222352092 neural precursor cell expressed, developmentally do... 63 2e-09
gi|222352090 neural precursor cell expressed, developmentally do... 63 2e-09
gi|222352088 neural precursor cell expressed, developmentally do... 63 2e-09
gi|222352086 neural precursor cell expressed, developmentally do... 63 2e-09
gi|222352084 neural precursor cell expressed, developmentally do... 63 2e-09
gi|222352082 neural precursor cell expressed, developmentally do... 63 2e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 63 2e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 63 2e-09
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 2317 bits (6004), Expect = 0.0
Identities = 1192/1192 (100%), Positives = 1192/1192 (100%)
Query: 1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELP 60
MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELP
Sbjct: 1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELP 60
Query: 61 WGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHV 120
WGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHV
Sbjct: 61 WGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHV 120
Query: 121 KEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKR 180
KEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKR
Sbjct: 121 KEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKR 180
Query: 181 ELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQ 240
ELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQ
Sbjct: 181 ELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQ 240
Query: 241 DLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRS 300
DLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRS
Sbjct: 241 DLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRS 300
Query: 301 NLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQF 360
NLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQF
Sbjct: 301 NLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQF 360
Query: 361 VTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLT 420
VTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLT
Sbjct: 361 VTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLT 420
Query: 421 TYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDV 480
TYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDV
Sbjct: 421 TYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDV 480
Query: 481 DYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAP 540
DYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAP
Sbjct: 481 DYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAP 540
Query: 541 KSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLI 600
KSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLI
Sbjct: 541 KSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLI 600
Query: 601 ENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSA 660
ENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSA
Sbjct: 601 ENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSA 660
Query: 661 AVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIA 720
AVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIA
Sbjct: 661 AVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIA 720
Query: 721 QLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQ 780
QLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQ
Sbjct: 721 QLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQ 780
Query: 781 QKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDS 840
QKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDS
Sbjct: 781 QKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDS 840
Query: 841 VFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLR 900
VFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLR
Sbjct: 841 VFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLR 900
Query: 901 EASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPT 960
EASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPT
Sbjct: 901 EASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPT 960
Query: 961 LVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRS 1020
LVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRS
Sbjct: 961 LVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRS 1020
Query: 1021 DSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQ 1080
DSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQ
Sbjct: 1021 DSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQ 1080
Query: 1081 SRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGL 1140
SRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGL
Sbjct: 1081 SRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGL 1140
Query: 1141 NAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV 1192
NAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV
Sbjct: 1141 NAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV 1192
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 1000 bits (2586), Expect = 0.0
Identities = 584/1186 (49%), Positives = 766/1186 (64%), Gaps = 79/1186 (6%)
Query: 9 QLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFD 68
+LPLP GWEEARD+DGKV+YIDH R TSWIDPRDR TKPL+FADC+ DELP GWE +D
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
Query: 69 PQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALA 128
PQ+G Y+IDH KTTQIEDPR QWR EQE MLKDYL VAQ+AL QKE+Y VK+QRL LA
Sbjct: 65 PQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELA 124
Query: 129 LDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQE 188
EY +L+ ++ K S SL SGSSSS+KYDP+ILKAEI+T + RV KLKRE+ ++ E
Sbjct: 125 QQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHE 184
Query: 189 LLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAK 248
L +KE+GF+TL++IDKKMS Q Y+L EA+A+L E K+I+KAI+ GEKEKQDL++SLA
Sbjct: 185 LQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAM 244
Query: 249 LQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRL 308
L++ F D+ S +S L +Q LD SQT ISG G+ S + LAEKVRL
Sbjct: 245 LKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRL 304
Query: 309 SLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQ 368
L+YEEAKR +ANLKI+L+KLDSEAWPG LD E+++L+LINEKEELLKE++F++P+K TQ
Sbjct: 305 RLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQ 364
Query: 369 DELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLK 428
E+E+LE R+RLE++L + R T S+AL ERL+L +R +L+++LEE T+ LHSQLK
Sbjct: 365 GEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLK 424
Query: 429 SLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDF 488
SLS+S S+SSGSS GSL SSRGSL SS S S S T+LYY +Q+D + Q K++F
Sbjct: 425 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYY-DPFEQLDSELQSKVEF 483
Query: 489 LLQE-KSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLS 547
LL E +G+ PSG ITTIHE+EV K+ G L + + L+ PKS+ SLS
Sbjct: 484 LLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRS--------LSGTPKSMTSLS 535
Query: 548 SRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLD 607
RSSLSS SPP SPL+ + P+ + DA L+ + +FED ELS+ ++SL
Sbjct: 536 PRSSLSSPSPPCSPLMAD---PLLAG-DAFLN--SLEFEDPELSATLCELSL-------- 581
Query: 608 SDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESV 667
S E L E E G A G K CVSAAVSDESV
Sbjct: 582 ------GNSAQERYRLEEPGTEGKQLGQA--------VNTAQGCGLKVACVSAAVSDESV 627
Query: 668 AGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHA 727
AGDSGVYEA V++ E + ++ V ++QI L+Y+ K+ F ++I QL NL A
Sbjct: 628 AGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSA 687
Query: 728 FLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVD 787
L KV RVAVLP S +CLFRT+ +++++FN+VF V++S AL QKTLRVD
Sbjct: 688 LLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVD 747
Query: 788 LCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQP 847
+C+ + EECL G QISLA++ S E T WYNLL K + + E V P
Sbjct: 748 VCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPAS- 806
Query: 848 LVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIV 907
DAVSALL +T+ EL E+ + G+ + + W ++ +
Sbjct: 807 --GPASTDAVSALLEQTAVEL----------EKRQEGRSSTQTLEDSWRYEETSENEAVA 854
Query: 908 AEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTL-VDKET 966
E+E EV E+ ED+ + + P+M DG P L VDKET
Sbjct: 855 EEEEEEV---EEEEGEEDVFTEKASPDM--DG------------------YPALKVDKET 891
Query: 967 NTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSST 1026
NT+ A VRPK+R + Q PF+R S I+RS+TFSPG ++QY+CRLNRSDSDSST
Sbjct: 892 NTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSST 951
Query: 1027 LAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDE 1086
L+KK FVRNS ERRS+R+KR S ++ E +RTSLDLELDLQA+ T S+L E
Sbjct: 952 LSKKPPFVRNSLERRSVRMKR---PSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQE 1008
Query: 1087 LQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLM 1146
+ L++L+++LE+ K+ GE +LP + EDERF+ LL+ EK+ + + E K L +K+M
Sbjct: 1009 ISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKR-QMDRAEHKGELQTDKMM 1067
Query: 1147 RQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV 1192
R +KDV RLR QS K P +VQSFREK+A+FTR +++IP+L ADDV
Sbjct: 1068 RAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1113
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 998 bits (2580), Expect = 0.0
Identities = 584/1189 (49%), Positives = 766/1189 (64%), Gaps = 79/1189 (6%)
Query: 9 QLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFD 68
+LPLP GWEEARD+DGKV+YIDH R TSWIDPRDR TKPL+FADC+ DELP GWE +D
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
Query: 69 PQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALA 128
PQ+G Y+IDH KTTQIEDPR QWR EQE MLKDYL VAQ+AL QKE+Y VK+QRL LA
Sbjct: 65 PQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELA 124
Query: 129 LDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQE 188
EY +L+ ++ K S SL SGSSSS+KYDP+ILKAEI+T + RV KLKRE+ ++ E
Sbjct: 125 QQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHE 184
Query: 189 LLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAK 248
L +KE+GF+TL++IDKKMS Q Y+L EA+A+L E K+I+KAI+ GEKEKQDL++SLA
Sbjct: 185 LQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAM 244
Query: 249 LQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRL 308
L++ F D+ S +S L +Q LD SQT ISG G+ S + LAEKVRL
Sbjct: 245 LKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRL 304
Query: 309 SLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQ 368
L+YEEAKR +ANLKI+L+KLDSEAWPG LD E+++L+LINEKEELLKE++F++P+K TQ
Sbjct: 305 RLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQ 364
Query: 369 DELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLK 428
E+E+LE R+RLE++L + R T S+AL ERL+L +R +L+++LEE T+ LHSQLK
Sbjct: 365 GEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLK 424
Query: 429 SLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDF 488
SLS+S S+SSGSS GSL SSRGSL SS S S S T+LYY +Q+D + Q K++F
Sbjct: 425 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYY-DPFEQLDSELQSKVEF 483
Query: 489 LLQE-KSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLS 547
LL E +G+ PSG ITTIHE+EV K+ G L + + L+ PKS+ SLS
Sbjct: 484 LLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRS--------LSGTPKSMTSLS 535
Query: 548 SRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLD 607
RSSLSS SPP SPL+ + P+ + DA L+ + +FED ELS+ ++SL
Sbjct: 536 PRSSLSSPSPPCSPLMAD---PLLAG-DAFLN--SLEFEDPELSATLCELSL-------- 581
Query: 608 SDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESV 667
S E L E E G A G K CVSAAVSDESV
Sbjct: 582 ------GNSAQERYRLEEPGTEGKQLGQA--------VNTAQGCGLKVACVSAAVSDESV 627
Query: 668 AGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHA 727
AGDSGVYEA V++ E + ++ V ++QI L+Y+ K+ F ++I QL NL A
Sbjct: 628 AGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSA 687
Query: 728 FLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVD 787
L KV RVAVLP S +CLFRT+ +++++FN+VF V++S AL QKTLRVD
Sbjct: 688 LLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVD 747
Query: 788 LCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQP 847
+C+ + EECL G QISLA++ S E T WYNLL K + + E V P
Sbjct: 748 VCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPAS- 806
Query: 848 LVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIV 907
DAVSALL +T+ EL E+ + G+ + + W ++ +
Sbjct: 807 --GPASTDAVSALLEQTAVEL----------EKRQEGRSSTQTLEDSWRYEETSENEAVA 854
Query: 908 AEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTL-VDKET 966
E+E EV E+ ED+ + + P+M DG P L VDKET
Sbjct: 855 EEEEEEV---EEEEGEEDVFTEKASPDM--DG------------------YPALKVDKET 891
Query: 967 NTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSST 1026
NT+ A VRPK+R + Q PF+R S I+RS+TFSPG ++QY+CRLNRSDSDSST
Sbjct: 892 NTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSST 951
Query: 1027 LAKKSLFVRNSTERRSLRVKR---TVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRL 1083
L+KK FVRNS ERRS+R+KR S ++ E +RTSLDLELDLQA+ T S+L
Sbjct: 952 LSKKPPFVRNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQL 1011
Query: 1084 NDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAE 1143
E+ L++L+++LE+ K+ GE +LP + EDERF+ LL+ EK+ + + E K L +
Sbjct: 1012 TQEISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKR-QMDRAEHKGELQTD 1070
Query: 1144 KLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV 1192
K+MR +KDV RLR QS K P +VQSFREK+A+FTR +++IP+L ADDV
Sbjct: 1071 KMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1119
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 998 bits (2579), Expect = 0.0
Identities = 584/1189 (49%), Positives = 767/1189 (64%), Gaps = 80/1189 (6%)
Query: 9 QLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFD 68
+LPLP GWEEARD+DGKV+YIDH R TSWIDPRDR TKPL+FADC+ DELP GWE +D
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD 64
Query: 69 PQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALA 128
PQ+G Y+IDH KTTQIEDPR QWR EQE MLKDYL VAQ+AL QKE+Y VK+QRL LA
Sbjct: 65 PQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELA 124
Query: 129 LDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQE 188
EY +L+ ++ K S SL SGSSSS+KYDP+ILKAEI+T + RV KLKRE+ ++ E
Sbjct: 125 QQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHE 184
Query: 189 LLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAK 248
L +KE+GF+TL++IDKKMS Q Y+L EA+A+L E K+I+KAI+ GEKEKQDL++SLA
Sbjct: 185 LQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAM 244
Query: 249 LQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRL 308
L++ F D+ S +S L +Q LD SQT ISG G+ S + LAEKVRL
Sbjct: 245 LKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRL 304
Query: 309 SLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQ 368
L+YEEAKR +ANLKI+L+KLDSEAWPG LD E+++L+LINEKEELLKE++F++P+K TQ
Sbjct: 305 RLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQ 364
Query: 369 DELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLK 428
E+E+LE R+RLE++L + R T S+AL ERL+L +R +L+++LEE T+ LHSQLK
Sbjct: 365 GEVEQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLK 424
Query: 429 SLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDF 488
SLS+S S+SSGSS GSL SSRGSL SS S S S T+LYY +Q+D + Q K++F
Sbjct: 425 SLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYY-DPFEQLDSELQSKVEF 483
Query: 489 LLQE-KSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLS 547
LL E +G+ PSG ITTIHE+EV K+ G L + + L+ PKS+ SLS
Sbjct: 484 LLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRS--------LSGTPKSMTSLS 535
Query: 548 SRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLD 607
RSSLSS SPP SPL+ + P+ + DA L+ + +FED ELS+ ++SL
Sbjct: 536 PRSSLSSPSPPCSPLMAD---PLLAG-DAFLN--SLEFEDPELSATLCELSL-------- 581
Query: 608 SDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESV 667
S E L E E G A G K CVSAAVSDESV
Sbjct: 582 ------GNSAQERYRLEEPGTEGKQLGQA--------VNTAQGCGLKVACVSAAVSDESV 627
Query: 668 AGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHA 727
AGDSGVYEA V++ E + ++ V ++QI L+Y+ K+ F ++I QL NL A
Sbjct: 628 AGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQLSNLSA 687
Query: 728 FLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVD 787
L KV RVAVLP S +CLFRT+ +++++FN+VF V++S AL QKTLRVD
Sbjct: 688 LLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALHQKTLRVD 747
Query: 788 LCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQP 847
+C+ + EECL G QISLA++ S E T WYNLL K + + E V P
Sbjct: 748 VCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKPVGVMAPAS- 806
Query: 848 LVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIV 907
DAVSALL +T+ EL E+ + G+ + + W ++ +
Sbjct: 807 --GPASTDAVSALLEQTAVEL----------EKRQEGRSSTQTLEDSWRYEETSENEAVA 854
Query: 908 AEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTL-VDKET 966
E+E EV E+ ED+ + + P+M DG P L VDKET
Sbjct: 855 EEEEEEV---EEEEGEEDVFTEKASPDM--DG------------------YPALKVDKET 891
Query: 967 NTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSST 1026
NT+ A VRPK+R + Q PF+R S I+RS+TFSPG ++QY+CRLNRSDSDSST
Sbjct: 892 NTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSST 951
Query: 1027 LAKKSLFVRNSTERRSLRVKR---TVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRL 1083
L+KK FVRNS ERRS+R+KR S ++ E +RTSLDLELDLQA+ T S+L
Sbjct: 952 LSKKPPFVRNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELDLQATRTWHSQL 1011
Query: 1084 NDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAE 1143
E+ L++L+++LE+ K+ GE +LP + EDERF+ LL+ EK+ +++ E K L +
Sbjct: 1012 TQEISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRMDRA--EHKGELQTD 1069
Query: 1144 KLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV 1192
K+MR +KDV RLR QS K P +VQSFREK+A+FTR +++IP+L ADDV
Sbjct: 1070 KMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV 1118
>gi|38570149 WWC family member 3 [Homo sapiens]
Length = 1092
Score = 763 bits (1969), Expect = 0.0
Identities = 491/1136 (43%), Positives = 690/1136 (60%), Gaps = 63/1136 (5%)
Query: 76 IDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRL 135
+DHINK TQIEDPR+QWR EQE+MLK+YL VAQ+AL +KE+Y +K+QR LA +EY +L
Sbjct: 1 MDHINKLTQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQL 60
Query: 136 NDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQG 195
+ ++ S S+ S FSG S++TKYDP +KAEI++ R R+ +LKREL+QMKQEL YKE+G
Sbjct: 61 HKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKG 120
Query: 196 FETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHL 255
ETLQ+ID+KMS + Y+L EA+AI++EL++I+KAI +GEKE++DLM SLAKL + F
Sbjct: 121 VETLQEIDRKMSSTHTSYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKN 180
Query: 256 DQNIGRSEPDL-RCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEE 314
++ S D V + +Q DAGSQT I G+ ++ L ++VRL+ QYEE
Sbjct: 181 SCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEE 240
Query: 315 AKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERL 374
A++ +AN++ +L++LD+E+WP + ++++L LI EKE LL+ELQ + Q+R+ ++ RL
Sbjct: 241 ARKRVANIQQQLARLDNESWPSTAEADRDRLQLIKEKEALLQELQLIIAQRRSAGDVARL 300
Query: 375 EAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSAST 434
E ER+RLEEEL R T ++ ER+ L+E+R LL +LEE T+LT+YL SQLKSL AST
Sbjct: 301 EEERERLEEELRRARATSAQGATERILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCAST 360
Query: 435 LSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKS 494
L++SSGSS GSLASSRGSL SSRGSL+S+S T++Y Q ++ D + L F L
Sbjct: 361 LTVSSGSSRGSLASSRGSL-ASSRGSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLI--- 416
Query: 495 GYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSS 554
P ++ + P PG SG + + P+S+ASLSSRSSLSS
Sbjct: 417 ------PFDSLGRDAPFSEP--PGPSGFHKQRRS--------LDTPQSLASLSSRSSLSS 460
Query: 555 LSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLDSDSGGAS 614
LSPP SPL T + +S D+ L Q E L + D + D D G +
Sbjct: 461 LSPPSSPL---DTPFLPASRDSPLAQLADSCEGPGLGA--LDRLRAHASAMGDEDLPGMA 515
Query: 615 QSL-----SEDKDLNECAREPL---YEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDES 666
+ + +E P GT + + KR L + +SA +SD S
Sbjct: 516 ALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKR-----LERRARRISACLSDYS 570
Query: 667 VAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLH 726
+A DSGV+E K+ + E+ Y D A Q+ +GL ++ S +V + QL+N
Sbjct: 571 LASDSGVFEPLTKRNEDAEEPAYG--DTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPA 628
Query: 727 AFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRV 786
+ KV+ RV + P + + +K ++FN+VFR+ + +AL K+L++
Sbjct: 629 GLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQL 688
Query: 787 DLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNL-LPSKQMPCKKNE---ENEDSVF 842
+CSV+ +EE L QI+LAD SE+ W+++ + + P + E E S
Sbjct: 689 YVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGCAGESSAR 748
Query: 843 QPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLR-E 901
P + S DAV+ LLART+A+L AVE+ELA+E + EE + L M R E
Sbjct: 749 DPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAKLEYTEE------EVLEMERKE 802
Query: 902 ASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPE---MNEDGNRKESNCAKDLRSQPP--T 956
E ++E+ + DS C+ + PE M D A+ P
Sbjct: 803 EQAEAISERSWQAD-SVDSGCSNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQ 861
Query: 957 RIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICR 1016
P VDKETNT++ + A KER S +R PFVRS IVRSQTFSPG R+QY+CR
Sbjct: 862 PSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIVRSQTFSPGARSQYVCR 921
Query: 1017 LNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQAS 1076
L RSDSDSSTL +KS FVRN+ ERR+LR K++ C+S L E RTSLDLELDLQAS
Sbjct: 922 LYRSDSDSSTLPRKSPFVRNTLERRTLRYKQS-CRSSL----AELMARTSLDLELDLQAS 976
Query: 1077 LTRQSRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQ 1136
TRQ +LN+EL ALR+LRQ+LE+ + +G+TDLPP VL DER + LL++AE+Q Q+K +
Sbjct: 977 RTRQRQLNEELCALRELRQRLEDAQLRGQTDLPPWVLRDERLRGLLREAERQTRQTKLDY 1036
Query: 1137 KQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV 1192
+ AEK++++ SK++ +LR QS K P QVQ+FREKIA+FTR +I+IP LPADDV
Sbjct: 1037 RHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQTFREKIAFFTRPRINIPPLPADDV 1092
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 90.9 bits (224), Expect = 7e-18
Identities = 43/92 (46%), Positives = 58/92 (63%), Gaps = 6/92 (6%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQ 70
PLP+ WE A G +++IDHNT+ T+W+DPR K + DC ELP+GWE DPQ
Sbjct: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
Query: 71 IGVYYIDHINKTTQIEDP-----RKQWRGEQE 97
G YY+DH+N+ TQ E+P RK+ G+ E
Sbjct: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQLGQVE 384
Score = 32.0 bits (71), Expect = 3.6
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
+ LP WE + +Y+IDH KTT DPR
Sbjct: 293 EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR 325
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 90.9 bits (224), Expect = 7e-18
Identities = 43/92 (46%), Positives = 58/92 (63%), Gaps = 6/92 (6%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQ 70
PLP+ WE A G +++IDHNT+ T+W+DPR K + DC ELP+GWE DPQ
Sbjct: 294 PLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR-LCKKAKAPEDCEDGELPYGWEKIEDPQ 352
Query: 71 IGVYYIDHINKTTQIEDP-----RKQWRGEQE 97
G YY+DH+N+ TQ E+P RK+ G+ E
Sbjct: 353 YGTYYVDHLNQKTQFENPVEEAKRKKQLGQVE 384
Score = 32.0 bits (71), Expect = 3.6
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
+ LP WE + +Y+IDH KTT DPR
Sbjct: 293 EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPR 325
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 88.2 bits (217), Expect = 4e-17
Identities = 41/79 (51%), Positives = 53/79 (67%), Gaps = 3/79 (3%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR-DRLTKPLSFADCVGDELPWGWEAGFDP 69
PLP WE A G+V++IDHNT+ TSW+DPR + KP +C +ELP+GWE DP
Sbjct: 303 PLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPE--ECKENELPYGWEKIDDP 360
Query: 70 QIGVYYIDHINKTTQIEDP 88
G YY+DHIN+ TQ E+P
Sbjct: 361 IYGTYYVDHINRRTQFENP 379
Score = 35.0 bits (79), Expect = 0.43
Identities = 16/33 (48%), Positives = 19/33 (57%)
Query: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
D LP WE + + VY+IDH KTT DPR
Sbjct: 302 DPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR 334
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 87.4 bits (215), Expect = 7e-17
Identities = 51/135 (37%), Positives = 71/135 (52%), Gaps = 21/135 (15%)
Query: 1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR--DRLTKPLSFADCVGD- 57
+P A PLP WE A +G+V++IDHNT+ TSW+DPR ++ KPL +C D
Sbjct: 291 LPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLE--ECEDDE 348
Query: 58 -----------ELPWGWEAGFDPQIGVYYIDHINKTTQIEDP-----RKQWRGEQEKMLK 101
ELP GWE DP G+YY+DHIN+ TQ E+P RK+ +Q++ +
Sbjct: 349 GVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQ 408
Query: 102 DYLSVAQDALRTQKE 116
Q + Q E
Sbjct: 409 QQQQQQQQQQQQQTE 423
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 87.4 bits (215), Expect = 7e-17
Identities = 51/135 (37%), Positives = 71/135 (52%), Gaps = 21/135 (15%)
Query: 1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR--DRLTKPLSFADCVGD- 57
+P A PLP WE A +G+V++IDHNT+ TSW+DPR ++ KPL +C D
Sbjct: 291 LPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLE--ECEDDE 348
Query: 58 -----------ELPWGWEAGFDPQIGVYYIDHINKTTQIEDP-----RKQWRGEQEKMLK 101
ELP GWE DP G+YY+DHIN+ TQ E+P RK+ +Q++ +
Sbjct: 349 GVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQ 408
Query: 102 DYLSVAQDALRTQKE 116
Q + Q E
Sbjct: 409 QQQQQQQQQQQQQTE 423
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 87.4 bits (215), Expect = 7e-17
Identities = 51/135 (37%), Positives = 71/135 (52%), Gaps = 21/135 (15%)
Query: 1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR--DRLTKPLSFADCVGD- 57
+P A PLP WE A +G+V++IDHNT+ TSW+DPR ++ KPL +C D
Sbjct: 291 LPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLE--ECEDDE 348
Query: 58 -----------ELPWGWEAGFDPQIGVYYIDHINKTTQIEDP-----RKQWRGEQEKMLK 101
ELP GWE DP G+YY+DHIN+ TQ E+P RK+ +Q++ +
Sbjct: 349 GVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQ 408
Query: 102 DYLSVAQDALRTQKE 116
Q + Q E
Sbjct: 409 QQQQQQQQQQQQQTE 423
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 68.6 bits (166), Expect = 3e-11
Identities = 41/141 (29%), Positives = 65/141 (46%), Gaps = 30/141 (21%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQI 71
LP GWE+ +D G+ +Y+DHNTR T+W P+ LP GWE D +
Sbjct: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ---------------PLPPGWERRVDDRR 395
Query: 72 GVYYIDHINKTTQIEDPR-------KQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQR 124
VYY+DH +TT + P +QW+ ++ ++ Q A++ + Y
Sbjct: 396 RVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQL--------QGAMQQFNQRYLYSASM 447
Query: 125 LALALDEYVRLNDAYKEKSSS 145
LA D Y L ++++ S
Sbjct: 448 LAAENDPYGPLPPGWEKRVDS 468
Score = 63.5 bits (153), Expect = 1e-09
Identities = 31/79 (39%), Positives = 46/79 (58%), Gaps = 7/79 (8%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQ 70
PLP GWE+ D +V++++HNT+ T W DPR T+ L + LP GWE + +
Sbjct: 457 PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPR---TQGLQNE----EPLPEGWEIRYTRE 509
Query: 71 IGVYYIDHINKTTQIEDPR 89
Y++DH +TT +DPR
Sbjct: 510 GVRYFVDHNTRTTTFKDPR 528
Score = 61.6 bits (148), Expect = 4e-09
Identities = 41/117 (35%), Positives = 54/117 (46%), Gaps = 28/117 (23%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP--------------RDRLT--------KP 48
PLP GWE D +V+Y+DHNTR T+W P R++L +
Sbjct: 382 PLPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRY 441
Query: 49 LSFADCVGDE------LPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKM 99
L A + E LP GWE D VY+++H KTTQ EDPR Q +E +
Sbjct: 442 LYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPL 498
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/43 (44%), Positives = 27/43 (62%), Gaps = 1/43 (2%)
Query: 2 PRRAG-SGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRD 43
PR G + PLP GWE +G +++DHNTR T++ DPR+
Sbjct: 487 PRTQGLQNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRN 529
Score = 35.0 bits (79), Expect = 0.43
Identities = 15/33 (45%), Positives = 19/33 (57%)
Query: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
+ LP GWE DP YY+DH +TT E P+
Sbjct: 349 ETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ 381
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 67.0 bits (162), Expect = 1e-10
Identities = 33/81 (40%), Positives = 49/81 (60%), Gaps = 12/81 (14%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDR--LTKPLSFADCVGDELPWGWEAGFD 68
PLP GWE+ +D +G+V+Y++HNTR T W DPR + + +P LP GWE +
Sbjct: 406 PLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEP---------ALPPGWEMKYT 455
Query: 69 PQIGVYYIDHINKTTQIEDPR 89
+ Y++DH +TT +DPR
Sbjct: 456 SEGVRYFVDHNTRTTTFKDPR 476
Score = 64.7 bits (156), Expect = 5e-10
Identities = 36/113 (31%), Positives = 55/113 (48%), Gaps = 32/113 (28%)
Query: 2 PRRAGSGQLP--------LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFAD 53
P +G+ QLP LP GWE+ +G+V+Y+DHNT+ T+W P
Sbjct: 284 PSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERP------------ 331
Query: 54 CVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR-------KQWRGEQEKM 99
LP GWE DP+ YY+DH +TT + P +QW+ ++ ++
Sbjct: 332 -----LPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQL 379
Score = 57.8 bits (138), Expect = 6e-08
Identities = 39/109 (35%), Positives = 47/109 (43%), Gaps = 29/109 (26%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR-------------------------DRL 45
PLP GWE+ D G+ +Y+DHNTR T+W P R
Sbjct: 331 PLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRF 390
Query: 46 TKPLSFADCVGDEL---PWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQ 91
S A D L P GWE D VYY++H +TTQ EDPR Q
Sbjct: 391 LYQSSSASTDHDPLGPLPPGWEKRQDNG-RVYYVNHNTRTTQWEDPRTQ 438
Score = 37.4 bits (85), Expect = 0.086
Identities = 36/132 (27%), Positives = 50/132 (37%), Gaps = 21/132 (15%)
Query: 40 DPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQ-WRGEQEK 98
+P T+ L A D LP GWE P VYY+DH KTT E P W +
Sbjct: 283 EPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDP 342
Query: 99 MLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYKEKSS---------SHTSL 149
+ Y T + EYVR + ++ + + S L
Sbjct: 343 RGRFYYVDHNTRTTTWQR-----------PTAEYVRNYEQWQSQRNQLQGAMQHFSQRFL 391
Query: 150 FSGSSSSTKYDP 161
+ SS+ST +DP
Sbjct: 392 YQSSSASTDHDP 403
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 66.2 bits (160), Expect = 2e-10
Identities = 33/79 (41%), Positives = 43/79 (54%), Gaps = 7/79 (8%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQ 70
PLP GWE+ D +G+V++++HNTR T W DPR S LP GWE F
Sbjct: 398 PLPPGWEKRTDSNGRVYFVNHNTRITQWEDPR-------SQGQLNEKPLPEGWEMRFTVD 450
Query: 71 IGVYYIDHINKTTQIEDPR 89
Y++DH +TT DPR
Sbjct: 451 GIPYFVDHNRRTTTYIDPR 469
Score = 63.5 bits (153), Expect = 1e-09
Identities = 32/98 (32%), Positives = 49/98 (50%), Gaps = 22/98 (22%)
Query: 9 QLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFD 68
Q PLP GWE+ D G+V+Y+DH +RT+W P + LP GWE D
Sbjct: 284 QAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP---------------EPLPPGWERRVD 328
Query: 69 PQIGVYYIDHINKTTQIEDPR-------KQWRGEQEKM 99
+YY+DH +TT + P +QW+ ++ ++
Sbjct: 329 NMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQL 366
Score = 55.5 bits (132), Expect = 3e-07
Identities = 37/114 (32%), Positives = 48/114 (42%), Gaps = 33/114 (28%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP--------------RDRLTKPLS------ 50
PLP GWE D G+++Y+DH TR T+W P R +L +
Sbjct: 318 PLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRF 377
Query: 51 -------FADCVGDE------LPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQ 91
FA E LP GWE D VY+++H + TQ EDPR Q
Sbjct: 378 IYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQ 431
>gi|11141889 WW45 protein [Homo sapiens]
Length = 383
Score = 65.5 bits (158), Expect = 3e-10
Identities = 33/83 (39%), Positives = 39/83 (46%), Gaps = 12/83 (14%)
Query: 6 GSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEA 65
GS LPLP GW G+ +YIDHNT T W P +R + LP GWE
Sbjct: 195 GSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLER------------EGLPPGWER 242
Query: 66 GFDPQIGVYYIDHINKTTQIEDP 88
+ G YY+DH NK Q P
Sbjct: 243 VESSEFGTYYVDHTNKKAQYRHP 265
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 65.1 bits (157), Expect = 4e-10
Identities = 32/78 (41%), Positives = 41/78 (52%), Gaps = 6/78 (7%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQI 71
LP GWEE DG V+Y +H +T W P+ K V +LP+GWE D
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
Query: 72 GVYYIDHINKTTQIEDPR 89
V+++DHINK T DPR
Sbjct: 72 QVFFVDHINKRTTYLDPR 89
Score = 46.2 bits (108), Expect = 2e-04
Identities = 20/43 (46%), Positives = 29/43 (67%), Gaps = 6/43 (13%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPR------DRLTKP 48
LP GWE+ D +G+VF++DH +RT+++DPR D TKP
Sbjct: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKP 101
Score = 32.3 bits (72), Expect = 2.8
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
DELP GWE VYY +H + TQ E P+
Sbjct: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPK 48
>gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
sapiens]
Length = 189
Score = 65.1 bits (157), Expect = 4e-10
Identities = 32/78 (41%), Positives = 41/78 (52%), Gaps = 6/78 (7%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQI 71
LP GWEE DG V+Y +H +T W P+ K V +LP+GWE D
Sbjct: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
Query: 72 GVYYIDHINKTTQIEDPR 89
V+++DHINK T DPR
Sbjct: 72 QVFFVDHINKRTTYLDPR 89
Score = 46.2 bits (108), Expect = 2e-04
Identities = 20/43 (46%), Positives = 29/43 (67%), Gaps = 6/43 (13%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPR------DRLTKP 48
LP GWE+ D +G+VF++DH +RT+++DPR D TKP
Sbjct: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKP 101
Score = 32.3 bits (72), Expect = 2.8
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
DELP GWE VYY +H + TQ E P+
Sbjct: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPK 48
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 63.9 bits (154), Expect = 9e-10
Identities = 35/83 (42%), Positives = 47/83 (56%), Gaps = 5/83 (6%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPL---SFADCVGD--ELPWGWEAG 66
LP+GWE +G+ F+IDHNT+ T+W DPR ++ L + D D LP GWE
Sbjct: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 482
Query: 67 FDPQIGVYYIDHINKTTQIEDPR 89
++YI+H K TQ EDPR
Sbjct: 483 THTDGRIFYINHNIKRTQWEDPR 505
Score = 58.5 bits (140), Expect = 4e-08
Identities = 36/104 (34%), Positives = 46/104 (44%), Gaps = 26/104 (25%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP-------RDRLTKPLSFA------------ 52
LP GWEE +D G+ +Y+DHN+R T+W P +LT S A
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
Query: 53 -------DCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
+ LP GWE P ++IDH KTT EDPR
Sbjct: 410 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPR 453
Score = 52.4 bits (124), Expect = 3e-06
Identities = 20/32 (62%), Positives = 24/32 (75%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG++FYI+HN +RT W DPR
Sbjct: 474 PLPPGWEERTHTDGRIFYINHNIKRTQWEDPR 505
Score = 45.8 bits (107), Expect = 2e-04
Identities = 19/38 (50%), Positives = 26/38 (68%), Gaps = 2/38 (5%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSW--IDPRDRLT 46
PLP GWEE +D G+ +Y++H +RRT W P+D LT
Sbjct: 192 PLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLT 229
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 63.9 bits (154), Expect = 9e-10
Identities = 35/83 (42%), Positives = 47/83 (56%), Gaps = 5/83 (6%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPL---SFADCVGD--ELPWGWEAG 66
LP+GWE +G+ F+IDHNT+ T+W DPR ++ L + D D LP GWE
Sbjct: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 829
Query: 67 FDPQIGVYYIDHINKTTQIEDPR 89
++YI+H K TQ EDPR
Sbjct: 830 THTDGRIFYINHNIKRTQWEDPR 852
Score = 58.5 bits (140), Expect = 4e-08
Identities = 36/104 (34%), Positives = 46/104 (44%), Gaps = 26/104 (25%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP-------RDRLTKPLSFA------------ 52
LP GWEE +D G+ +Y+DHN+R T+W P +LT S A
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
Query: 53 -------DCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
+ LP GWE P ++IDH KTT EDPR
Sbjct: 757 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPR 800
Score = 52.4 bits (124), Expect = 3e-06
Identities = 20/32 (62%), Positives = 24/32 (75%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG++FYI+HN +RT W DPR
Sbjct: 821 PLPPGWEERTHTDGRIFYINHNIKRTQWEDPR 852
Score = 45.8 bits (107), Expect = 2e-04
Identities = 19/38 (50%), Positives = 26/38 (68%), Gaps = 2/38 (5%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSW--IDPRDRLT 46
PLP GWEE +D G+ +Y++H +RRT W P+D LT
Sbjct: 539 PLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLT 576
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQ 461
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 459
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 479 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 538
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 539 HLDGRTFYIDHNSKITQWEDPRLQ 562
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 529 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 560
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRLQ 441
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 439
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRLQ 441
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 408 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 439
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 471 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 530
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 531 HLDGRTFYIDHNSKITQWEDPRLQ 554
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 521 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 552
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 491 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 550
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 551 HLDGRTFYIDHNSKITQWEDPRLQ 574
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 541 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 572
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 408
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 499 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 558
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 559 HLDGRTFYIDHNSKITQWEDPRLQ 582
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 549 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 580
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 416
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQ 461
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 459
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/84 (40%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDE----LPWGWEAGF 67
LP GWE +G+ F+IDHNT+ T+W DPR + + + LP GWE
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 68 DPQIGVYYIDHINKTTQIEDPRKQ 91
+YIDH +K TQ EDPR Q
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQ 461
Score = 50.4 bits (119), Expect = 1e-05
Identities = 20/32 (62%), Positives = 23/32 (71%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR 42
PLP GWEE DG+ FYIDHN++ T W DPR
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDPR 459
Score = 43.9 bits (102), Expect = 0.001
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
LP GWEE +D G+ +Y++HN R T+W P
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 42.0 bits (97), Expect = 0.003
Identities = 16/31 (51%), Positives = 20/31 (64%)
Query: 11 PLPRGWEEARDYDGKVFYIDHNTRRTSWIDP 41
PLP GWEE D G+ +Y++HN R T W P
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 31.2 bits (69), Expect = 6.1
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 59 LPWGWEAGFDPQIGVYYIDHINKTTQIEDP 88
LP GWE D YY++H N+TTQ P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 62.8 bits (151), Expect = 2e-09
Identities = 100/433 (23%), Positives = 184/433 (42%), Gaps = 69/433 (15%)
Query: 87 DPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLAL---ALDEYVRLNDA-YKEK 142
+ +K+ GE+ + LK L D+ TQ+EL +EQ + + ALDE R ++A +E
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 143 SSSHTSLFSGSSSS------TKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGF 196
H + K + D K + + R L Q KQE+ +K++
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 197 ET-LQQIDKKMSGGQSGYE-------------------LSEAKAILTELKSIRKAISSGE 236
E +Q++ K S G+ L+EA+ +L ++SS
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 237 KEKQDLMQ-----------SLAKLQE-----RFHLDQNI-GRSEPDLRCSPVNSHLCLSR 279
++ Q+L+Q L +L+E + LD+ + + + S +N L S+
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 280 QTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALD 339
+ L + T + + G + E L+ QYEE + L+ ++L E +D
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIE--NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 340 IEKEKLMLINEKEELLKELQFVTPQK----RTQDELERLEAERQRLEEELLSVRGTPSRA 395
++ ++ ++ N +++ K Q + +K + DE +R EAE + E + LS+ +RA
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL----ARA 1491
Query: 396 LAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNT 455
L E L +E +LE T K+ L ++++ L +S + G ++ L S+ +L T
Sbjct: 1492 LEEALEAKE-------ELERTNKM---LKAEMEDLVSSKDDV--GKNVHELEKSKRALET 1539
Query: 456 SSRGSLNSLSSTE 468
L E
Sbjct: 1540 QMEEMKTQLEELE 1552
Score = 55.1 bits (131), Expect = 4e-07
Identities = 81/414 (19%), Positives = 173/414 (41%), Gaps = 56/414 (13%)
Query: 85 IEDPRKQWRGEQEKMLKDYLSVAQDALRTQKE----LYHVKEQRLALALDEYVRLNDAYK 140
+ D + ++ K+L++ +S L ++E L +K + ++ + VRL K
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048
Query: 141 EKSSSHTSLFSGSSSSTKYDPDI--LKAEISTTRLRVKKLKREL----SQMKQELLYKEQ 194
+ ++ + I L+A+I+ ++++ K + EL +++ E+ K
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 195 GFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFH 254
+ +++++ +S Q +L S R A + EK+K+DL + L L+
Sbjct: 1109 ALKKIRELEGHISDLQE------------DLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Query: 255 LDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEE 314
+ ++ +LR + + ++ LD +++ + +R + A + L+ Q E+
Sbjct: 1157 DTLDSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE-ELTEQLEQ 1214
Query: 315 AKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERL 374
KR+ ANL +K K L E +L EL+ + K + +
Sbjct: 1215 FKRAKANL------------------DKNKQTLEKENADLAGELRVLGQAK------QEV 1250
Query: 375 EAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSAST 434
E ++++LE ++ ++ S R L ++ +L ++E T + + L+
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 435 LSMSSGSSLGSLASSRGSLNTSSRGSLN---SLSSTELYYSSQSDQIDVDYQYK 485
S+SS L ++ L +R LN L E +S DQ+D + + K
Sbjct: 1311 ASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Score = 53.9 bits (128), Expect = 9e-07
Identities = 91/456 (19%), Positives = 180/456 (39%), Gaps = 60/456 (13%)
Query: 77 DHINKTTQIEDPRKQWRGEQEKMLKDY--LSVAQDALRTQKELYHVKEQRLALALDEYVR 134
D + +E+ +K+++ E E + + Y + A D L K + L + LD +
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 135 LNDAYKEKSSSHTSLFSGSSS-STKYDPDILKAEISTTRLRVKKLK-----RELSQMKQE 188
L ++K L + + S+KY + +AE K L E + K+E
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 189 L--LYKEQGFETLQQIDKKMSGGQSGYELSEAKAIL--------TELKSIRKAISSGEKE 238
L K E + K G++ +EL ++K L T+L+ + + + E
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 239 KQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLC---------LSRQTLDAGSQTS 289
K L ++ L+ +F D + + + + L ++ L A ++
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Query: 290 ISGDI---------GVRSRSNLAEKVR-LSLQYEEAKRSMANLKIELSKLDSEAWPG--- 336
+ GD+ ++ R +++R L Q ++ +R + + + ++ + A
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 337 ALDIEKEKLMLIN--------------EKEELLKEL-QFVTPQKRTQDELERLEAERQRL 381
A +E + + L EKEEL +EL ++ + QDE RLEA +L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741
Query: 382 EEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGS 441
EEEL +G A+++R+R ++ E L T + T +Q + L +
Sbjct: 1742 EEELEEEQGN-MEAMSDRVRKATQQAEQLSNELATERST----AQKNESARQQLERQNKE 1796
Query: 442 SLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQ 477
L G++ + + ++ +L + Q +Q
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Score = 53.1 bits (126), Expect = 2e-06
Identities = 73/352 (20%), Positives = 144/352 (40%), Gaps = 54/352 (15%)
Query: 80 NKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALAL------DEYV 133
N+ + + G+ K+ KD S++ TQ+ L Q+L ++ +E
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 134 RLNDAYKEKSSS------HTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQ 187
L D E+ + H S + S +K + + K+ ++E+ + Q
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 188 ELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLA 247
+ K ++ L++ ++ E ++ +L + R+ +S+ EK+++ Q LA
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQ--------QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458
Query: 248 KLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVR 307
+ ++NI D R R +A + + + + L K
Sbjct: 1459 E-------EKNISSKYADER----------DRAEAEAREKETKALSLARALEEALEAK-- 1499
Query: 308 LSLQYEEAKRSMANLKIELSKLDS---EAWPGALDIEKEKLMLINEKEELLKELQFVTPQ 364
EE +R+ LK E+ L S + ++EK K L + EE+ +L+
Sbjct: 1500 -----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE----- 1549
Query: 365 KRTQDELERLEAERQRLEEELLSVRGTPSRALAER-LRLEERRKELLQKLEE 415
+DEL+ E + RLE + +++G R L R + EE+R++L ++L E
Sbjct: 1550 -ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Score = 42.0 bits (97), Expect = 0.003
Identities = 76/350 (21%), Positives = 141/350 (40%), Gaps = 42/350 (12%)
Query: 851 SIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIVAEK 910
S L LL + + L V +L Q EEE + + D L EA + E+
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDEEMEAKQNL--ER 1364
Query: 911 EAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTL--VDKETNT 968
+ S + L S E E+G ++ ++L Q + ++K N
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 969 DEAANDNMAVRPKER----SSLSSRQHPFVRSSVIVRSQTFSP---GERNQYICRLNRSD 1021
+ D++ V + S+L +Q F ++ + S ER++ +
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKF--DQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 1022 SDSSTLAK---KSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPV----RTSLDLELDLQ 1074
+ + +LA+ ++L + ER + +K + V + V ++ LE ++
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 1075 ASLTRQSRLNDELQALRDLRQKLE----ELKAQGETDLPPGVLEDE----RFQRLLKQAE 1126
T+ L DELQA D + +LE LK Q E DL ++E + QR L + E
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 1127 KQAEQSKEEQKQGLNAEKLMRQVSKDV-------CRLREQSQKVPRQVQS 1169
+ E ++++ A+K + KD+ + RE++ K R++Q+
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Score = 41.2 bits (95), Expect = 0.006
Identities = 76/328 (23%), Positives = 139/328 (42%), Gaps = 36/328 (10%)
Query: 114 QKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSS--SSTKYDPDILKAEISTT 171
Q+E KE L + + + KE H+ L + L AE
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 172 RLRVKKLKRELSQ----MKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKS 227
R+R+ K+EL + M+ L +E + LQ KKM+ Q +L E L E ++
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA--QQMLDLEEQ---LEEEEA 964
Query: 228 IRKAISSGEKEKQDLMQSLAKLQERFHL--DQNIGRSEP----DLRCSPVNSHLCLSRQT 281
R+ + + EK + KL++ + DQN S+ + R S + ++L +
Sbjct: 965 ARQKL---QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 282 LDAGSQTSISGDIGVRSRSNLAE-KVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDI 340
A + T + + S ++E +VRL + E++++ + LK +L S+ D+
Sbjct: 1022 --AKNLTKLKN----KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 341 EKE----KLMLINEKEELLKEL----QFVTPQKRTQDELERLEAERQRLEEELLSVRGTP 392
+ + K+ L ++EEL L + + ++ LE L+E+L S R
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 393 SRALAERLRLEERRKELLQKLEETTKLT 420
++A ++ L E + L +LE+T T
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDST 1162
Score = 37.0 bits (84), Expect = 0.11
Identities = 46/213 (21%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 221 ILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQ 280
+ T++K + + ++ E+E Q L K +ER +N E + + S + L ++
Sbjct: 837 LFTKVKPLLQ-VTRQEEEMQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQE 894
Query: 281 TLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDI 340
L A ++ + +VRL+ + +E + + ++ L + + +
Sbjct: 895 QLQAETELYAEAE---------EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 341 EKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERL 400
+K +++ +E+L +E +++ Q E EA+ ++LE+E+L + ++ ER
Sbjct: 946 KKMAQQMLDLEEQLEEE---EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 401 RLEERRKELLQKL---EETTKLTTYLHSQLKSL 430
LEER +L L EE K T L ++ +S+
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Score = 35.0 bits (79), Expect = 0.43
Identities = 72/373 (19%), Positives = 148/373 (39%), Gaps = 64/373 (17%)
Query: 83 TQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQ--------KELYHVKEQRLALALDEY-V 133
TQ+E+ + + ++ L+ L V AL+ Q E K ++L L EY
Sbjct: 1546 TQLEELEDELQATEDAKLR--LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1603
Query: 134 RLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKE 193
L D K+++ + +++ K + D+ E+ Q + +E
Sbjct: 1604 ELEDERKQRALA-------AAAKKKLEGDLKDLEL---------------QADSAIKGRE 1641
Query: 194 QGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERF 253
+ + L+++ +M Q EL +A+A E+ + K EK+ + L L +LQE
Sbjct: 1642 EAIKQLRKLQAQMKDFQR--ELEDARASRDEIFATAK---ENEKKAKSLEADLMQLQEDL 1696
Query: 254 HLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEK--VRLSLQ 311
+ R + DL + L +S+SG ++ E +L +
Sbjct: 1697 AAAER-ARKQADLEKEELAEELA-----------SSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 312 YEEAKRSMANLKIELSKLDSEAWPGALDI----------EKEKLMLINEKEELLKELQFV 361
EE + +M + + K +A + ++ E + L + +EL +L +
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804
Query: 362 --TPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKL 419
+ + + + LEA+ +LEE++ A + +++ KE+L ++E+ K+
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 420 TTYLHSQLKSLSA 432
Q + +A
Sbjct: 1865 AEQYKEQAEKGNA 1877
Score = 34.3 bits (77), Expect = 0.73
Identities = 27/118 (22%), Positives = 52/118 (44%), Gaps = 11/118 (9%)
Query: 1069 LELDLQASLTRQSRLNDELQALRDLRQKLEE---LKAQGETDLPPGVLEDERFQRLLKQA 1125
L+L+ + + +L DE+ + D KL + L + +DL + E+E + L +
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028
Query: 1126 EKQAEQS--------KEEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIA 1175
+ + E K+E+K EKL R++ D EQ + Q+ + ++A
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Score = 34.3 bits (77), Expect = 0.73
Identities = 83/418 (19%), Positives = 159/418 (38%), Gaps = 52/418 (12%)
Query: 812 FSSEVFTLWYNLLPSKQMPCKKNEENE-------DSVFQPNQPL---------VDSIDLD 855
F ++ L + K KK EE + D + Q N L + + D
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 856 AVSALLARTSAE---------LLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEI 906
S AR AE L A++ EL + + Q+E R +T+L++A DE
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 907 VAEKEAEVK---------LPEDSSCTEDLSSCTSVPEMNEDGNRKE-SNCAKDLR--SQP 954
EA+V+ + E + E + + N+ KE ++ A +LR Q
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 955 PTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYI 1014
+ K + + + R+ L+ + H V S T E
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE---VESVTGMLNEAEGKA 1303
Query: 1015 CRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQ 1074
+L + + S+ + + + R+ L V + Q R + ++ LD E++ +
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS----LQDQLDEEMEAK 1359
Query: 1075 ASLTRQ-SRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSK 1133
+L R S LN +L D ++KL++ + E L G +RFQ+ ++ +Q E+
Sbjct: 1360 QNLERHISTLNIQLS---DSKKKLQDFASTVEA-LEEG---KKRFQKEIENLTQQYEEKA 1412
Query: 1134 EEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADD 1191
+ + ++Q D+ + +++ ++ + K + +I S AD+
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 62.8 bits (151), Expect = 2e-09
Identities = 100/433 (23%), Positives = 184/433 (42%), Gaps = 69/433 (15%)
Query: 87 DPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLAL---ALDEYVRLNDA-YKEK 142
+ +K+ GE+ + LK L D+ TQ+EL +EQ + + ALDE R ++A +E
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 143 SSSHTSLFSGSSSS------TKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGF 196
H + K + D K + + R L Q KQE+ +K++
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 197 ET-LQQIDKKMSGGQSGYE-------------------LSEAKAILTELKSIRKAISSGE 236
E +Q++ K S G+ L+EA+ +L ++SS
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 237 KEKQDLMQ-----------SLAKLQE-----RFHLDQNI-GRSEPDLRCSPVNSHLCLSR 279
++ Q+L+Q L +L+E + LD+ + + + S +N L S+
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 280 QTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALD 339
+ L + T + + G + E L+ QYEE + L+ ++L E +D
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIE--NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 340 IEKEKLMLINEKEELLKELQFVTPQK----RTQDELERLEAERQRLEEELLSVRGTPSRA 395
++ ++ ++ N +++ K Q + +K + DE +R EAE + E + LS+ +RA
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL----ARA 1498
Query: 396 LAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNT 455
L E L +E +LE T K+ L ++++ L +S + G ++ L S+ +L T
Sbjct: 1499 LEEALEAKE-------ELERTNKM---LKAEMEDLVSSKDDV--GKNVHELEKSKRALET 1546
Query: 456 SSRGSLNSLSSTE 468
L E
Sbjct: 1547 QMEEMKTQLEELE 1559
Score = 55.1 bits (131), Expect = 4e-07
Identities = 81/414 (19%), Positives = 173/414 (41%), Gaps = 56/414 (13%)
Query: 85 IEDPRKQWRGEQEKMLKDYLSVAQDALRTQKE----LYHVKEQRLALALDEYVRLNDAYK 140
+ D + ++ K+L++ +S L ++E L +K + ++ + VRL K
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055
Query: 141 EKSSSHTSLFSGSSSSTKYDPDI--LKAEISTTRLRVKKLKREL----SQMKQELLYKEQ 194
+ ++ + I L+A+I+ ++++ K + EL +++ E+ K
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 195 GFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFH 254
+ +++++ +S Q +L S R A + EK+K+DL + L L+
Sbjct: 1116 ALKKIRELEGHISDLQE------------DLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Query: 255 LDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEE 314
+ ++ +LR + + ++ LD +++ + +R + A + L+ Q E+
Sbjct: 1164 DTLDSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE-ELTEQLEQ 1221
Query: 315 AKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERL 374
KR+ ANL +K K L E +L EL+ + K + +
Sbjct: 1222 FKRAKANL------------------DKNKQTLEKENADLAGELRVLGQAK------QEV 1257
Query: 375 EAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSAST 434
E ++++LE ++ ++ S R L ++ +L ++E T + + L+
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 435 LSMSSGSSLGSLASSRGSLNTSSRGSLN---SLSSTELYYSSQSDQIDVDYQYK 485
S+SS L ++ L +R LN L E +S DQ+D + + K
Sbjct: 1318 ASLSS-----QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Score = 53.9 bits (128), Expect = 9e-07
Identities = 91/456 (19%), Positives = 180/456 (39%), Gaps = 60/456 (13%)
Query: 77 DHINKTTQIEDPRKQWRGEQEKMLKDY--LSVAQDALRTQKELYHVKEQRLALALDEYVR 134
D + +E+ +K+++ E E + + Y + A D L K + L + LD +
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 135 LNDAYKEKSSSHTSLFSGSSS-STKYDPDILKAEISTTRLRVKKLK-----RELSQMKQE 188
L ++K L + + S+KY + +AE K L E + K+E
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 189 L--LYKEQGFETLQQIDKKMSGGQSGYELSEAKAIL--------TELKSIRKAISSGEKE 238
L K E + K G++ +EL ++K L T+L+ + + + E
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 239 KQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLC---------LSRQTLDAGSQTS 289
K L ++ L+ +F D + + + + L ++ L A ++
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Query: 290 ISGDI---------GVRSRSNLAEKVR-LSLQYEEAKRSMANLKIELSKLDSEAWPG--- 336
+ GD+ ++ R +++R L Q ++ +R + + + ++ + A
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 337 ALDIEKEKLMLIN--------------EKEELLKEL-QFVTPQKRTQDELERLEAERQRL 381
A +E + + L EKEEL +EL ++ + QDE RLEA +L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748
Query: 382 EEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGS 441
EEEL +G A+++R+R ++ E L T + T +Q + L +
Sbjct: 1749 EEELEEEQGN-MEAMSDRVRKATQQAEQLSNELATERST----AQKNESARQQLERQNKE 1803
Query: 442 SLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQ 477
L G++ + + ++ +L + Q +Q
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Score = 53.1 bits (126), Expect = 2e-06
Identities = 73/352 (20%), Positives = 144/352 (40%), Gaps = 54/352 (15%)
Query: 80 NKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALAL------DEYV 133
N+ + + G+ K+ KD S++ TQ+ L Q+L ++ +E
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 134 RLNDAYKEKSSS------HTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQ 187
L D E+ + H S + S +K + + K+ ++E+ + Q
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 188 ELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLA 247
+ K ++ L++ ++ E ++ +L + R+ +S+ EK+++ Q LA
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQ--------QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465
Query: 248 KLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVR 307
+ ++NI D R R +A + + + + L K
Sbjct: 1466 E-------EKNISSKYADER----------DRAEAEAREKETKALSLARALEEALEAK-- 1506
Query: 308 LSLQYEEAKRSMANLKIELSKLDS---EAWPGALDIEKEKLMLINEKEELLKELQFVTPQ 364
EE +R+ LK E+ L S + ++EK K L + EE+ +L+
Sbjct: 1507 -----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE----- 1556
Query: 365 KRTQDELERLEAERQRLEEELLSVRGTPSRALAER-LRLEERRKELLQKLEE 415
+DEL+ E + RLE + +++G R L R + EE+R++L ++L E
Sbjct: 1557 -ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Score = 42.0 bits (97), Expect = 0.003
Identities = 76/350 (21%), Positives = 141/350 (40%), Gaps = 42/350 (12%)
Query: 851 SIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIVAEK 910
S L LL + + L V +L Q EEE + + D L EA + E+
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDEEMEAKQNL--ER 1371
Query: 911 EAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTL--VDKETNT 968
+ S + L S E E+G ++ ++L Q + ++K N
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 969 DEAANDNMAVRPKER----SSLSSRQHPFVRSSVIVRSQTFSP---GERNQYICRLNRSD 1021
+ D++ V + S+L +Q F ++ + S ER++ +
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKF--DQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 1022 SDSSTLAK---KSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPV----RTSLDLELDLQ 1074
+ + +LA+ ++L + ER + +K + V + V ++ LE ++
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 1075 ASLTRQSRLNDELQALRDLRQKLE----ELKAQGETDLPPGVLEDE----RFQRLLKQAE 1126
T+ L DELQA D + +LE LK Q E DL ++E + QR L + E
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 1127 KQAEQSKEEQKQGLNAEKLMRQVSKDV-------CRLREQSQKVPRQVQS 1169
+ E ++++ A+K + KD+ + RE++ K R++Q+
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Score = 41.2 bits (95), Expect = 0.006
Identities = 76/328 (23%), Positives = 139/328 (42%), Gaps = 36/328 (10%)
Query: 114 QKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSS--SSTKYDPDILKAEISTT 171
Q+E KE L + + + KE H+ L + L AE
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 172 RLRVKKLKRELSQ----MKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKS 227
R+R+ K+EL + M+ L +E + LQ KKM+ Q +L E L E ++
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA--QQMLDLEEQ---LEEEEA 971
Query: 228 IRKAISSGEKEKQDLMQSLAKLQERFHL--DQNIGRSEP----DLRCSPVNSHLCLSRQT 281
R+ + + EK + KL++ + DQN S+ + R S + ++L +
Sbjct: 972 ARQKL---QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 282 LDAGSQTSISGDIGVRSRSNLAE-KVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDI 340
A + T + + S ++E +VRL + E++++ + LK +L S+ D+
Sbjct: 1029 --AKNLTKLKN----KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 341 EKE----KLMLINEKEELLKEL----QFVTPQKRTQDELERLEAERQRLEEELLSVRGTP 392
+ + K+ L ++EEL L + + ++ LE L+E+L S R
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 393 SRALAERLRLEERRKELLQKLEETTKLT 420
++A ++ L E + L +LE+T T
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDST 1169
Score = 37.0 bits (84), Expect = 0.11
Identities = 46/213 (21%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 221 ILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQ 280
+ T++K + + ++ E+E Q L K +ER +N E + + S + L ++
Sbjct: 844 LFTKVKPLLQ-VTRQEEEMQAKEDELQKTKERQQKAEN-ELKELEQKHSQLTEEKNLLQE 901
Query: 281 TLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDI 340
L A ++ + +VRL+ + +E + + ++ L + + +
Sbjct: 902 QLQAETELYAEAE---------EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 341 EKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERL 400
+K +++ +E+L +E +++ Q E EA+ ++LE+E+L + ++ ER
Sbjct: 953 KKMAQQMLDLEEQLEEE---EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 401 RLEERRKELLQKL---EETTKLTTYLHSQLKSL 430
LEER +L L EE K T L ++ +S+
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Score = 35.0 bits (79), Expect = 0.43
Identities = 72/373 (19%), Positives = 148/373 (39%), Gaps = 64/373 (17%)
Query: 83 TQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQ--------KELYHVKEQRLALALDEY-V 133
TQ+E+ + + ++ L+ L V AL+ Q E K ++L L EY
Sbjct: 1553 TQLEELEDELQATEDAKLR--LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET 1610
Query: 134 RLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKE 193
L D K+++ + +++ K + D+ E+ Q + +E
Sbjct: 1611 ELEDERKQRALA-------AAAKKKLEGDLKDLEL---------------QADSAIKGRE 1648
Query: 194 QGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERF 253
+ + L+++ +M Q EL +A+A E+ + K EK+ + L L +LQE
Sbjct: 1649 EAIKQLRKLQAQMKDFQR--ELEDARASRDEIFATAK---ENEKKAKSLEADLMQLQEDL 1703
Query: 254 HLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEK--VRLSLQ 311
+ R + DL + L +S+SG ++ E +L +
Sbjct: 1704 AAAER-ARKQADLEKEELAEELA-----------SSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 312 YEEAKRSMANLKIELSKLDSEAWPGALDI----------EKEKLMLINEKEELLKELQFV 361
EE + +M + + K +A + ++ E + L + +EL +L +
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811
Query: 362 --TPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKL 419
+ + + + LEA+ +LEE++ A + +++ KE+L ++E+ K+
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 420 TTYLHSQLKSLSA 432
Q + +A
Sbjct: 1872 AEQYKEQAEKGNA 1884
Score = 34.3 bits (77), Expect = 0.73
Identities = 27/118 (22%), Positives = 52/118 (44%), Gaps = 11/118 (9%)
Query: 1069 LELDLQASLTRQSRLNDELQALRDLRQKLEE---LKAQGETDLPPGVLEDERFQRLLKQA 1125
L+L+ + + +L DE+ + D KL + L + +DL + E+E + L +
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035
Query: 1126 EKQAEQS--------KEEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIA 1175
+ + E K+E+K EKL R++ D EQ + Q+ + ++A
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Score = 34.3 bits (77), Expect = 0.73
Identities = 83/418 (19%), Positives = 159/418 (38%), Gaps = 52/418 (12%)
Query: 812 FSSEVFTLWYNLLPSKQMPCKKNEENE-------DSVFQPNQPL---------VDSIDLD 855
F ++ L + K KK EE + D + Q N L + + D
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 856 AVSALLARTSAE---------LLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEI 906
S AR AE L A++ EL + + Q+E R +T+L++A DE
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 907 VAEKEAEVK---------LPEDSSCTEDLSSCTSVPEMNEDGNRKE-SNCAKDLR--SQP 954
EA+V+ + E + E + + N+ KE ++ A +LR Q
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 955 PTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYI 1014
+ K + + + R+ L+ + H V S T E
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE---VESVTGMLNEAEGKA 1310
Query: 1015 CRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQ 1074
+L + + S+ + + + R+ L V + Q R + ++ LD E++ +
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS----LQDQLDEEMEAK 1366
Query: 1075 ASLTRQ-SRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSK 1133
+L R S LN +L D ++KL++ + E L G +RFQ+ ++ +Q E+
Sbjct: 1367 QNLERHISTLNIQLS---DSKKKLQDFASTVEA-LEEG---KKRFQKEIENLTQQYEEKA 1419
Query: 1134 EEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADD 1191
+ + ++Q D+ + +++ ++ + K + +I S AD+
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.349
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,604,585
Number of Sequences: 37866
Number of extensions: 1998112
Number of successful extensions: 15562
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 180
Number of HSP's successfully gapped in prelim test: 744
Number of HSP's that attempted gapping in prelim test: 10453
Number of HSP's gapped (non-prelim): 4372
length of query: 1192
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1078
effective length of database: 13,930,794
effective search space: 15017395932
effective search space used: 15017395932
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.