Search of human proteins with 155030194

Search of human proteins with 155030194

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
         (607 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [...  1162   0.0  
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [...  1157   0.0  
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [...  1154   0.0  
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [...  1030   0.0  
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [...  1027   0.0  
gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6 [...   753   0.0  
gi|189409124 armadillo repeat containing 3 [Homo sapiens]              59   1e-08
gi|224589129 karyopherin 7 [Homo sapiens]                              48   2e-05
gi|31657114 armadillo repeat containing 4 [Homo sapiens]               47   4e-05
gi|39812229 karyopherin alpha 5 [Homo sapiens]                         46   9e-05
gi|4504897 karyopherin alpha 2 [Homo sapiens]                          44   3e-04
gi|4504811 junction plakoglobin [Homo sapiens]                         41   0.004
gi|12056468 junction plakoglobin [Homo sapiens]                        41   0.004
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur...    40   0.006
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]     39   0.011
gi|53729346 plakophilin 1 isoform 1b [Homo sapiens]                    39   0.014
gi|53729344 plakophilin 1 isoform 1a [Homo sapiens]                    39   0.014
gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo ...    39   0.014
gi|15529984 armadillo repeat containing 6 [Homo sapiens]               39   0.014
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]         38   0.031
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]        38   0.031
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD...    37   0.053
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD...    37   0.053
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ...    37   0.053
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]     36   0.090
gi|7106299 ataxin 10 [Homo sapiens]                                    36   0.12 
gi|4504901 karyopherin alpha 4 [Homo sapiens]                          35   0.15 
gi|222144293 karyopherin alpha 1 [Homo sapiens]                        34   0.45 
gi|146231975 catenin, delta 1 isoform 3A [Homo sapiens]                34   0.45 
gi|146231948 catenin, delta 1 isoform 3A [Homo sapiens]                34   0.45 

>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
           [Homo sapiens]
          Length = 607

 Score = 1162 bits (3006), Expect = 0.0
 Identities = 607/607 (100%), Positives = 607/607 (100%)

Query: 1   MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT 60
           MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT
Sbjct: 1   MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT 60

Query: 61  PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD 120
           PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD
Sbjct: 61  PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD 120

Query: 121 SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM 180
           SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM
Sbjct: 121 SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM 180

Query: 181 GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD 240
           GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD
Sbjct: 181 GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD 240

Query: 241 KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL 300
           KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL
Sbjct: 241 KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL 300

Query: 301 LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV 360
           LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV
Sbjct: 301 LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV 360

Query: 361 EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ 420
           EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ
Sbjct: 361 EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ 420

Query: 421 FKLLGTLRMLIDAQEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK 480
           FKLLGTLRMLIDAQEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK
Sbjct: 421 FKLLGTLRMLIDAQEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSK 480

Query: 481 DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR 540
           DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR
Sbjct: 481 DVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHR 540

Query: 541 LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE 600
           LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE
Sbjct: 541 LLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTE 600

Query: 601 QRLTVES 607
           QRLTVES
Sbjct: 601 QRLTVES 607


>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
           [Homo sapiens]
          Length = 608

 Score = 1157 bits (2994), Expect = 0.0
 Identities = 607/608 (99%), Positives = 607/608 (99%), Gaps = 1/608 (0%)

Query: 1   MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT 60
           MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT
Sbjct: 1   MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT 60

Query: 61  PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD 120
           PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD
Sbjct: 61  PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD 120

Query: 121 SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM 180
           SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM
Sbjct: 121 SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM 180

Query: 181 GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD 240
           GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD
Sbjct: 181 GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD 240

Query: 241 KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL 300
           KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL
Sbjct: 241 KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL 300

Query: 301 LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV 360
           LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV
Sbjct: 301 LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV 360

Query: 361 EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ 420
           EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ
Sbjct: 361 EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ 420

Query: 421 FKLLGTLRMLIDAQ-EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
           FKLLGTLRMLIDAQ EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS
Sbjct: 421 FKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 480

Query: 480 KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILH 539
           KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILH
Sbjct: 481 KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILH 540

Query: 540 RLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLT 599
           RLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLT
Sbjct: 541 RLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLT 600

Query: 600 EQRLTVES 607
           EQRLTVES
Sbjct: 601 EQRLTVES 608


>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
           [Homo sapiens]
          Length = 607

 Score = 1154 bits (2985), Expect = 0.0
 Identities = 605/606 (99%), Positives = 605/606 (99%), Gaps = 1/606 (0%)

Query: 3   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 62
           DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ
Sbjct: 2   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 61

Query: 63  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 122
           SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH
Sbjct: 62  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 121

Query: 123 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 182
           EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV
Sbjct: 122 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 181

Query: 183 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 242
           IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR
Sbjct: 182 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 241

Query: 243 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 302
           EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL
Sbjct: 242 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 301

Query: 303 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 362
           GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK
Sbjct: 302 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 361

Query: 363 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422
           LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK
Sbjct: 362 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421

Query: 423 LLGTLRMLIDAQ-EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 481
           LLGTLRMLIDAQ EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD
Sbjct: 422 LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 481

Query: 482 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 541
           VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL
Sbjct: 482 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 541

Query: 542 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 601
           LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ
Sbjct: 542 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 601

Query: 602 RLTVES 607
           RLTVES
Sbjct: 602 RLTVES 607


>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
           [Homo sapiens]
          Length = 559

 Score = 1030 bits (2664), Expect = 0.0
 Identities = 555/608 (91%), Positives = 557/608 (91%), Gaps = 50/608 (8%)

Query: 1   MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT 60
           MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT
Sbjct: 1   MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT 60

Query: 61  PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD 120
           PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY 
Sbjct: 61  PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY- 119

Query: 121 SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM 180
                                                           ++ SLQAQLINM
Sbjct: 120 ------------------------------------------------DSHSLQAQLINM 131

Query: 181 GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD 240
           GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD
Sbjct: 132 GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD 191

Query: 241 KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL 300
           KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL
Sbjct: 192 KREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLL 251

Query: 301 LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV 360
           LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV
Sbjct: 252 LLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIV 311

Query: 361 EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ 420
           EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ
Sbjct: 312 EKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQ 371

Query: 421 FKLLGTLRMLIDAQ-EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
           FKLLGTLRMLIDAQ EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS
Sbjct: 372 FKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 431

Query: 480 KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILH 539
           KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILH
Sbjct: 432 KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILH 491

Query: 540 RLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLT 599
           RLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLT
Sbjct: 492 RLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLT 551

Query: 600 EQRLTVES 607
           EQRLTVES
Sbjct: 552 EQRLTVES 559


>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
           [Homo sapiens]
          Length = 558

 Score = 1027 bits (2655), Expect = 0.0
 Identities = 553/606 (91%), Positives = 555/606 (91%), Gaps = 50/606 (8%)

Query: 3   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 62
           DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ
Sbjct: 2   DNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQ 61

Query: 63  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSH 122
           SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY   
Sbjct: 62  SSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY--- 118

Query: 123 EGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGV 182
                                                         ++ SLQAQLINMGV
Sbjct: 119 ----------------------------------------------DSHSLQAQLINMGV 132

Query: 183 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 242
           IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR
Sbjct: 133 IPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKR 192

Query: 243 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 302
           EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL
Sbjct: 193 EMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLL 252

Query: 303 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 362
           GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK
Sbjct: 253 GDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEK 312

Query: 363 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422
           LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK
Sbjct: 313 LMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 372

Query: 423 LLGTLRMLIDAQ-EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 481
           LLGTLRMLIDAQ EAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD
Sbjct: 373 LLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKD 432

Query: 482 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 541
           VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL
Sbjct: 433 VIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRL 492

Query: 542 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 601
           LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ
Sbjct: 493 LADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQ 552

Query: 602 RLTVES 607
           RLTVES
Sbjct: 553 RLTVES 558


>gi|155030202 RAP1, GTP-GDP dissociation stimulator 1 isoform 6
           [Homo sapiens]
          Length = 516

 Score =  753 bits (1943), Expect = 0.0
 Identities = 405/441 (91%), Positives = 416/441 (94%), Gaps = 4/441 (0%)

Query: 169 ENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-ELESSKEQFASTNIAE 227
           +N+ ++   ++ G+I  LV+LL    Q   L      A GN+  + +SSKEQFASTNIAE
Sbjct: 78  KNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGR--ALGNICYDSQSSKEQFASTNIAE 135

Query: 228 ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDI 287
           ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDI
Sbjct: 136 ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDI 195

Query: 288 TELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARN 347
           TELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARN
Sbjct: 196 TELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARN 255

Query: 348 DANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEA 407
           DANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEA
Sbjct: 256 DANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEA 315

Query: 408 VLKFLKSEMPPVQFKLLGTLRMLIDAQ-EAAEQLGKNVKLVERLVEWCEAKDHAGVMGES 466
           VLKFLKSEMPPVQFKLLGTLRMLIDAQ EAAEQLGKNVKLVERLVEWCEAKDHAGVMGES
Sbjct: 316 VLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNVKLVERLVEWCEAKDHAGVMGES 375

Query: 467 NRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAE 526
           NRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAE
Sbjct: 376 NRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAE 435

Query: 527 KDLESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRS 586
           KDLESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRS
Sbjct: 436 KDLESAKLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLRS 495

Query: 587 HENKSVAQQASLTEQRLTVES 607
           HENKSVAQQASLTEQRLTVES
Sbjct: 496 HENKSVAQQASLTEQRLTVES 516


>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
          Length = 872

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 81/354 (22%), Positives = 155/354 (43%), Gaps = 37/354 (10%)

Query: 259 KLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSV 318
           K  L+E G VE L +++        ED I  ++  + ++  +L  +  ++KL    +  V
Sbjct: 60  KTTLLELGAVEPLTKLLTH------EDKI--VRRNATMIFGILASNNDVKKLLR--ELDV 109

Query: 319 FQRVLSWI-PSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVT 377
              V++ + P     +    +L +AN +    + + + ++G +E L+ LL     D    
Sbjct: 110 MNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPD---- 165

Query: 378 VQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQEAA 437
           V+  ++  + NL      +AK+        +L  LKSE P +Q   L TL ++ + +E+ 
Sbjct: 166 VKKNSMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESR 225

Query: 438 EQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVT 497
             L  N  L + L++  E K+   +  E+   L+ +    +  D +  I Q+GG+K L++
Sbjct: 226 TMLRDNQGL-DHLIKILETKELNDLHIEA---LAVIANCLEDMDTMVQIQQTGGLKKLLS 281

Query: 498 MATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV------QILHRLLADERSAPEI 551
            A       +N  +  +   AA  +  A  D E+ KL       + L  LL  E    +I
Sbjct: 282 FA-------ENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKI 334

Query: 552 KYNSMV-LICALMGSECLHKEVQDLAFLDVVSKLRSHENKSVAQQASLTEQRLT 604
             +  +  +C   GS    K+  +   +  + +L   +N+ V + A+L    LT
Sbjct: 335 AASQAISAMCENSGS----KDFFNNQGIPQLIQLLKSDNEEVREAAALALANLT 384



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 96/532 (18%), Positives = 219/532 (41%), Gaps = 58/532 (10%)

Query: 87  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
           +++   + +V +LNS ++E+L +   A+        E ++ + + G     ++ L  L +
Sbjct: 22  IESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELG----AVEPLTKLLT 77

Query: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 206
             D    +  T+  G+L +    N+ ++  L  + V+ +++  L    +   + E   + 
Sbjct: 78  HEDKIVRRNATMIFGILAS----NNDVKKLLRELDVMNSVIAQLAPE-EEVVIHEFASLC 132

Query: 207 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAG 266
             N++   +SK Q       E L++L     + D ++   E +  L ++   + +L E  
Sbjct: 133 LANMSAEYTSKVQIFEHGGLEPLIRLLSSP-DPDVKKNSMECIYNLVQDFQCRAKLQELN 191

Query: 267 LVECLLEIVQQK--------------VDSDKED--------------DITELKTGSDLMV 298
            +  +L++++ +              + +DKE                I E K  +DL +
Sbjct: 192 AIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHI 251

Query: 299 --LLLLGD--ESMQKLFEGGKGSVFQRVLSWIPSNN-HQLQLAGALAIANFARNDANCIH 353
             L ++ +  E M  + +  +    +++LS+  ++    +Q   A AI   A +  N   
Sbjct: 252 EALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYDPEN-RK 310

Query: 354 MVDNGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLK 413
           +     VEK +  L     DG       A+SA+   +    +K    + G+ + +++ LK
Sbjct: 311 LFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS---GSKDFFNNQGIPQ-LIQLLK 366

Query: 414 SEMPPVQFKLLGTLRMLIDAQEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSAL 473
           S+   V+      L  L     A          ++ L+    +K    +        + +
Sbjct: 367 SDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIAN-----AATV 421

Query: 474 IRHSKSKDVIKTIVQSGGIKH-LVTMATSEHVIMQNEALVALALIAALELGTAEKDLESA 532
           + +   ++ ++  +Q+  I H +++   S + ++Q++A  ALA+ A      A  +L ++
Sbjct: 422 LTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKA--ALAVTATACDVEARTELRNS 479

Query: 533 KLVQILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKL 584
             ++ L  LL  +        +  V++CA  G E    E+  L  LD++ ++
Sbjct: 480 GGLEPLVELLRSKNDEVRKHASWAVMVCA--GDELTANELCRLGALDILEEV 529


>gi|224589129 karyopherin 7 [Homo sapiens]
          Length = 516

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 66/287 (22%), Positives = 117/287 (40%), Gaps = 26/287 (9%)

Query: 87  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
           V+ G I PL++LL+S +  V  Q   ALGNI  D  E R  V  +      I HL +L S
Sbjct: 153 VEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSN----AIPHLLALIS 208

Query: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVA 206
            T P     L      L N     +          ++P L+ LL  H  +  L++ C  A
Sbjct: 209 PTLPIT--FLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQ-HQDSEVLSDACW-A 264

Query: 207 FGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEA 265
              L +  + +  Q  +T +   LV L      +     +  V   +   D      ++A
Sbjct: 265 LSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 324

Query: 266 GLVECLLEIVQQKVDSDKED---DITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 322
           G++  L +++Q    S +++    ++ +  G    +  LL  +            V   +
Sbjct: 325 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYD------------VLPPL 372

Query: 323 LSWIPSNNHQLQLAGALAIANFARNDA--NCIHMVDNGIVEKLMDLL 367
           ++ + +   ++Q      +ANFA        I +V +G++E L++LL
Sbjct: 373 VALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLL 419


>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
          Length = 1044

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 53/219 (24%), Positives = 91/219 (41%), Gaps = 17/219 (7%)

Query: 34  ALAQNNTETSEKIQASGILQLFASLL-TPQSSCKAKVANIIAEVAKNEFMRIPCVDAGLI 92
           +LAQ   + +  I+  G L++  +LL T +  CK     I+ E++ N  +R   VD G +
Sbjct: 480 SLAQETCQLA--IRDVGGLEVLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGL 537

Query: 93  SPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPAN 152
             +V +L+S  + +       + N+       R  V Q GG   ++  L      T PA 
Sbjct: 538 PIMVNILDSPHKSLKCLAAETIANVA-KFKRARRVVRQHGGITKLVALLDCAHDSTKPAQ 596

Query: 153 EKLL------TVFCGMLMNYSNENDSLQAQLI-NMGVIPTLVKLLGIHCQNAALTEMCLV 205
             L          CG L  +S        + I   G IP L +LL    +N     M + 
Sbjct: 597 SSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHEN-----MLIP 651

Query: 206 AFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREM 244
             G L E  +S+E + +   AE +++   K +  +  ++
Sbjct: 652 VVGTLQEC-ASEENYRAAIKAERIIENLVKNLNSENEQL 689



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 76/379 (20%), Positives = 153/379 (40%), Gaps = 40/379 (10%)

Query: 19   KTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVANIIAEVAK 78
            + E   E C   + Q     + ET + ++  G L+  ASLL    + K ++A +   + K
Sbjct: 685  ENEQLQEHCAMAIYQCA--EDKETRDLVRLHGGLKPLASLLNNTDN-KERLAAVTGAIWK 741

Query: 79   NEFMRIPCV---DAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQ 135
                +       +   I  LV LL  + +EVL+    ALG  C +  E R  V + GG Q
Sbjct: 742  CSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQE-RENRVIVRKCGGIQ 800

Query: 136  IVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTL--VKLLGIH 193
                          P    L+ +   +L+N +    +   +  +M +I  L  V+LL   
Sbjct: 801  --------------PLVNLLVGINQALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSL 846

Query: 194  CQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAP-- 251
             +N         A+     ++++K+           ++L    ++ D +E++  V A   
Sbjct: 847  LKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAIT 906

Query: 252  -LAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKL 310
             +A++      + + G+V  L ++      ++  ++         +    + G    +  
Sbjct: 907  NIAKDQENLAVITDHGVVPLLSKL------ANTNNNKLRHHLAEAISRCCMWG----RNR 956

Query: 311  FEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRH 370
               G+      ++ ++ SN+  +  A A A+   + +  NCI M +NG V+ L+D++   
Sbjct: 957  VAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSEDADNCITMHENGAVKLLLDMVGSP 1016

Query: 371  VEDGNVTVQHAALSALRNL 389
             +D    +Q AA   + N+
Sbjct: 1017 DQD----LQEAAAGCISNI 1031



 Score = 37.4 bits (85), Expect = 0.040
 Identities = 83/417 (19%), Positives = 160/417 (38%), Gaps = 29/417 (6%)

Query: 1   MADNLSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLT 60
           + D   D+ K  + +  +  +  +  C    L + ++++T      +A GI  L   L T
Sbjct: 584 LLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKT 643

Query: 61  PQSSCKAKVANIIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYD 120
              +    V   + E A  E  R       +I  LV+ LNS+++++      A+   C +
Sbjct: 644 SHENMLIPVVGTLQECASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQ-CAE 702

Query: 121 SHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINM 180
             E R  V   GG    +  L SL + TD  N++ L    G +   S   +++  +    
Sbjct: 703 DKETRDLVRLHGG----LKPLASLLNNTD--NKERLAAVTGAIWKCSISKENV-TKFREY 755

Query: 181 GVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHD 240
             I TLV LL    +   +    + A G   +   ++         + LV L     +  
Sbjct: 756 KAIETLVGLLTDQPEEVLVN--VVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQAL 813

Query: 241 KREMIFEVLAPLAENDAIKL--QLVEAGLVECLLEIVQQKVDSDKEDDITE-LKTGSDLM 297
              +   V A   E +++ +  +L    L+  LL+     V +     +   +K   D  
Sbjct: 814 LVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDA- 872

Query: 298 VLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDN 357
                    M + F GG     + +++ + S+N ++  +   AI N A++  N   + D+
Sbjct: 873 -------GEMVRSFVGG----LELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDH 921

Query: 358 GIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKS 414
           G+V     LL +     N  ++H    A+    +   N+           ++++LKS
Sbjct: 922 GVV----PLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVAPLVRYLKS 974


>gi|39812229 karyopherin alpha 5 [Homo sapiens]
          Length = 539

 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 44/280 (15%)

Query: 39  NTETSEKIQASGILQLFASLLTPQSSC--KAKVANIIAEVAKNEFMRIPCV-DAGLISPL 95
           N    + IQ  G++Q F   L    +C  + + A  +  +A   F+    V + G +   
Sbjct: 116 NPPIDQVIQKPGVVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIF 175

Query: 96  VQLLNSKDQEVLLQTGRALGNICYDSHEGRSAV----------------DQAGGAQIVID 139
           ++LLNS+ ++V  Q   ALGNI  D+ E R  V                ++    +  + 
Sbjct: 176 IKLLNSEHEDVQEQAVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVW 235

Query: 140 HLRSLCSITDP--------------------ANEKLLTVFCGMLMNYSN-ENDSLQAQLI 178
            L +LC   +P                    ++  +L   C  L   S+  ND +QA +I
Sbjct: 236 ALSNLCRGKNPPPNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQA-VI 294

Query: 179 NMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQ-FASTNIAEELVKLFKKQI 237
           + GV   LV+LL +H  +  +    L A GN+   +  + Q   + +    L+ L     
Sbjct: 295 DSGVCRRLVELL-MH-NDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPK 352

Query: 238 EHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQ 277
           E  ++E  + V    A N A    +++A +   L+EI+Q+
Sbjct: 353 ESIRKEACWTVSNITAGNRAQIQAVIDANIFPVLIEILQK 392


>gi|4504897 karyopherin alpha 2 [Homo sapiens]
          Length = 529

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 96/438 (21%), Positives = 168/438 (38%), Gaps = 84/438 (19%)

Query: 35  LAQNNTETSEKIQASGILQLFASLL--TPQSSCKAKVANIIAEVAKNEFMRIPCV-DAGL 91
           L++      + I  +G++  F S L  T  S  + + A  +  +A     +   V D G 
Sbjct: 104 LSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA 163

Query: 92  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151
           I   + LL S    +  Q   ALGNI  D    R  V + G     +D L +L ++ D  
Sbjct: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYG----AVDPLLALLAVPD-- 217

Query: 152 NEKLLTVFCGMLMNYS--------NENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMC 203
              + ++ CG L N +        N+N +     +   ++PTLV+LL  H     L + C
Sbjct: 218 ---MSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQ-ILPTLVRLLH-HDDPEVLADTC 272

Query: 204 LVAFGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQL 262
             A   L +  + +      T +  +LVKL                        A +L +
Sbjct: 273 W-AISYLTDGPNERIGMVVKTGVVPQLVKLL----------------------GASELPI 309

Query: 263 VEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 322
           V   L                   I  + TG+         DE  Q + + G  +VF  +
Sbjct: 310 VTPAL-----------------RAIGNIVTGT---------DEQTQVVIDAGALAVFPSL 343

Query: 323 LSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAA 382
           L+  P  N Q +    ++     R D     +V++G+V  L+ +L +     +   Q  A
Sbjct: 344 LT-NPKTNIQKEATWTMSNITAGRQD-QIQQVVNHGLVPFLVSVLSK----ADFKTQKEA 397

Query: 383 LSALRNLAI--PVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQEAAEQL 440
           + A+ N      V     ++  G+ E ++  L ++   +   +L  +  +    +AAE+L
Sbjct: 398 VWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF---QAAEKL 454

Query: 441 GKNVKLVERLVEWCEAKD 458
           G+  KL   ++E C   D
Sbjct: 455 GETEKL-SIMIEECGGLD 471


>gi|4504811 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 92/422 (21%), Positives = 160/422 (37%), Gaps = 66/422 (15%)

Query: 92  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151
           +  +V LLN  + + L  T   L  + Y + E +  +   GG Q ++  +R+       +
Sbjct: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323

Query: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211
            EKLL      ++   +   S +  ++  G +  L K L     +  L + CL    NL+
Sbjct: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380

Query: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267
           ++ + +E        E ++K+   Q+  D   ++      L+     N   K  + +   
Sbjct: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434

Query: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327
           VE L+  + +  D   +DDITE        V  L    S     E  + SV  R+   IP
Sbjct: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483

Query: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372
           +        N   L  A    I N A   AN   + +  ++ +L+ LL        RHV 
Sbjct: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543

Query: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422
            G             +      AL  LA   +N+ ++         ++ L S +  +Q  
Sbjct: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603

Query: 423 LLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
             G L  L   +EAA+ +   G +  L+E L        H+   G +    + L R S+ 
Sbjct: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655

Query: 480 KD 481
           K+
Sbjct: 656 KN 657


>gi|12056468 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 92/422 (21%), Positives = 160/422 (37%), Gaps = 66/422 (15%)

Query: 92  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151
           +  +V LLN  + + L  T   L  + Y + E +  +   GG Q ++  +R+       +
Sbjct: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323

Query: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211
            EKLL      ++   +   S +  ++  G +  L K L     +  L + CL    NL+
Sbjct: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380

Query: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267
           ++ + +E        E ++K+   Q+  D   ++      L+     N   K  + +   
Sbjct: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434

Query: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327
           VE L+  + +  D   +DDITE        V  L    S     E  + SV  R+   IP
Sbjct: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483

Query: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372
           +        N   L  A    I N A   AN   + +  ++ +L+ LL        RHV 
Sbjct: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543

Query: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422
            G             +      AL  LA   +N+ ++         ++ L S +  +Q  
Sbjct: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603

Query: 423 LLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479
             G L  L   +EAA+ +   G +  L+E L        H+   G +    + L R S+ 
Sbjct: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655

Query: 480 KD 481
           K+
Sbjct: 656 KN 657


>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
           plakophilin-related arm-repeat protein) [Homo sapiens]
          Length = 1225

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 26/98 (26%), Positives = 47/98 (47%), Gaps = 9/98 (9%)

Query: 95  LVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPANEK 154
           ++Q+L  +   V       L ++C+  ++ ++ + + GG Q+++D       + D    +
Sbjct: 555 VIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVD-------LLDHRMTE 607

Query: 155 LLTVFCGMLMN--YSNENDSLQAQLINMGVIPTLVKLL 190
           +    CG L N  Y   ND  +  L N G IP LV+LL
Sbjct: 608 VHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLL 645


>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
          Length = 493

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 34/218 (15%)

Query: 18  DKTEDSLEGCLDCLL------QALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVAN 71
           D  E++ EGC+  +L      Q L Q    T EK +   ++ L   L  P++        
Sbjct: 48  DAPEEAGEGCVAAILGETEVQQFLRQAQRGTEEKEREGALVSLRRGLQHPET-------- 99

Query: 72  IIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQA 131
                 +  F+R+     G +  LV LL S    + L+  R L  +   SH  +S V   
Sbjct: 100 ------QQTFIRLE----GSMRTLVGLLTSNQALLQLEAARCLHEL---SHSEQSTV--- 143

Query: 132 GGAQIVIDHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 191
             A+  +     L +     +   + +    L N   E+++++ QL+  G++P L     
Sbjct: 144 --AEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLLPQGIVPALAAC-- 199

Query: 192 IHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEEL 229
           I   + A+ E    A   L + E + E+   + +A  L
Sbjct: 200 IQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTL 237


>gi|53729346 plakophilin 1 isoform 1b [Homo sapiens]
          Length = 747

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 42/153 (27%), Positives = 65/153 (42%), Gaps = 13/153 (8%)

Query: 316 GSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDN-GIVEKLMDLLDRHVEDG 374
           G    + + ++ S + + Q  GA  I +    D +    V   G + KL+DLL       
Sbjct: 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLL----RSP 299

Query: 375 NVTVQHAALSALRNLAI-PVINKAKMLSA-GVTEAVLKFLKSEMPPVQFKLLGTLRMLID 432
           N  VQ AA  ALRNL      NK +     G+ EAV    ++    +Q +L G L  L  
Sbjct: 300 NQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359

Query: 433 AQEAAEQLGKNV--KLVERLV----EWCEAKDH 459
             E  E+L  +    L +R++     WC+   +
Sbjct: 360 TDELKEELIADALPVLADRVIIPFSGWCDGNSN 392



 Score = 30.4 bits (67), Expect = 4.9
 Identities = 46/199 (23%), Positives = 80/199 (40%), Gaps = 14/199 (7%)

Query: 89  AGLISP-LVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSI 147
           +GL  P  VQ L+S+D++        + + C+     +  V Q GG   ++D LRS    
Sbjct: 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS---- 298

Query: 148 TDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAF 207
               N+ +     G L N    + + + +      I   V LL     NA + +      
Sbjct: 299 ---PNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLR-RTGNAEIQKQLTGLL 354

Query: 208 GNLAELESSKEQF---ASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVE 264
            NL+  +  KE+    A   +A+ ++  F    + +   M  EV+ P    +A       
Sbjct: 355 WNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNS-NMSREVVDPEVFFNATGCLRKR 413

Query: 265 AGLVECLLEIVQQKVDSDK 283
            G+ E LL +V Q+  S +
Sbjct: 414 LGMRE-LLALVPQRATSSR 431


>gi|53729344 plakophilin 1 isoform 1a [Homo sapiens]
          Length = 726

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 42/153 (27%), Positives = 65/153 (42%), Gaps = 13/153 (8%)

Query: 316 GSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDN-GIVEKLMDLLDRHVEDG 374
           G    + + ++ S + + Q  GA  I +    D +    V   G + KL+DLL       
Sbjct: 244 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLL----RSP 299

Query: 375 NVTVQHAALSALRNLAI-PVINKAKMLSA-GVTEAVLKFLKSEMPPVQFKLLGTLRMLID 432
           N  VQ AA  ALRNL      NK +     G+ EAV    ++    +Q +L G L  L  
Sbjct: 300 NQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 359

Query: 433 AQEAAEQLGKNV--KLVERLV----EWCEAKDH 459
             E  E+L  +    L +R++     WC+   +
Sbjct: 360 TDELKEELIADALPVLADRVIIPFSGWCDGNSN 392



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 48/214 (22%), Positives = 86/214 (40%), Gaps = 24/214 (11%)

Query: 89  AGLISP-LVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSI 147
           +GL  P  VQ L+S+D++        + + C+     +  V Q GG   ++D LRS    
Sbjct: 243 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS---- 298

Query: 148 TDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAF 207
               N+ +     G L N    + + + +      I   V LL     NA + +      
Sbjct: 299 ---PNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLR-RTGNAEIQKQLTGLL 354

Query: 208 GNLAELESSKEQF---ASTNIAEELVKLFKKQIEHDKR--------EMIFEV---LAPLA 253
            NL+  +  KE+    A   +A+ ++  F    + +          E+ F     L  L+
Sbjct: 355 WNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRNLS 414

Query: 254 ENDAIKLQLVE-AGLVECLLEIVQQKVDSDKEDD 286
             DA +  +   +GL++ L+  VQ  V + + DD
Sbjct: 415 SADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 448


>gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo
           sapiens]
          Length = 625

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 42/153 (27%), Positives = 65/153 (42%), Gaps = 13/153 (8%)

Query: 316 GSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDN-GIVEKLMDLLDRHVEDG 374
           G    + + ++ S + + Q  GA  I +    D +    V   G + KL+DLL       
Sbjct: 143 GLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLL----RSP 198

Query: 375 NVTVQHAALSALRNLAI-PVINKAKMLSA-GVTEAVLKFLKSEMPPVQFKLLGTLRMLID 432
           N  VQ AA  ALRNL      NK +     G+ EAV    ++    +Q +L G L  L  
Sbjct: 199 NQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSS 258

Query: 433 AQEAAEQLGKNV--KLVERLV----EWCEAKDH 459
             E  E+L  +    L +R++     WC+   +
Sbjct: 259 TDELKEELIADALPVLADRVIIPFSGWCDGNSN 291



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 48/214 (22%), Positives = 86/214 (40%), Gaps = 24/214 (11%)

Query: 89  AGLISP-LVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSI 147
           +GL  P  VQ L+S+D++        + + C+     +  V Q GG   ++D LRS    
Sbjct: 142 SGLTIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRS---- 197

Query: 148 TDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAF 207
               N+ +     G L N    + + + +      I   V LL     NA + +      
Sbjct: 198 ---PNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIREAVSLLR-RTGNAEIQKQLTGLL 253

Query: 208 GNLAELESSKEQF---ASTNIAEELVKLFKKQIEHDKR--------EMIFEV---LAPLA 253
            NL+  +  KE+    A   +A+ ++  F    + +          E+ F     L  L+
Sbjct: 254 WNLSSTDELKEELIADALPVLADRVIIPFSGWCDGNSNMSREVVDPEVFFNATGCLRNLS 313

Query: 254 ENDAIKLQLVE-AGLVECLLEIVQQKVDSDKEDD 286
             DA +  +   +GL++ L+  VQ  V + + DD
Sbjct: 314 SADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 347


>gi|15529984 armadillo repeat containing 6 [Homo sapiens]
          Length = 476

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 56/228 (24%), Positives = 97/228 (42%), Gaps = 13/228 (5%)

Query: 388 NLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQEAAEQ---LGKNV 444
           N A  ++ + K L   + EA   FL +  P +  +L GTL  L    E  ++   LG   
Sbjct: 239 NHAKMIVQENKGLKV-LIEATKAFLDN--PGILSELCGTLSRLAIRNEFCQEVVDLGGLS 295

Query: 445 KLVERLVEWC---EAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATS 501
            LV  L + C   + +D +GV     ++LS L   + + DV   IV++GG + +V   T 
Sbjct: 296 ILVSLLAD-CNDHQMRDQSGVQELVKQVLSTLRAIAGNDDVKDAIVRAGGTESIVAAMTQ 354

Query: 502 EHVIMQ--NEALVALALIAALELGTAEKDLESAKLVQILHRLLADERSAPEIKYNSMVLI 559
                Q   ++  AL  +A  +   +   +E    V  L  + A  + A   K   M++ 
Sbjct: 355 HLTSPQVCEQSCAALCFLALRKPDNSRIIVEGGGAVAALQAMKAHPQKAGVQKQACMLIR 414

Query: 560 CALMGSECLHKEVQDLAFLDVVSKLRS-HENKSVAQQASLTEQRLTVE 606
             +   +   K + DL    ++ + RS H +     +A+L +    VE
Sbjct: 415 NLVAHGQAFSKPILDLGAEALIMQARSAHRDCEDVAKAALRDLGCHVE 462


>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
          Length = 509

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)

Query: 12  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230

Query: 71  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 129
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   + E    V 
Sbjct: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290

Query: 130 QAGGAQIVIDHLRS 143
            AGG   VID + S
Sbjct: 291 NAGGVAAVIDCIGS 304



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248

Query: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559
           E A++  ++   L D+     +K N+  LI
Sbjct: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275


>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
          Length = 458

 Score = 37.7 bits (86), Expect = 0.031
 Identities = 29/134 (21%), Positives = 61/134 (45%), Gaps = 2/134 (1%)

Query: 12  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKI-QASGILQLFASLLTPQSSCKAKVA 70
           L +  + + E +L+      L  +A+++ E ++ +  A  +  L   +L P +  K ++ 
Sbjct: 171 LLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQIL 230

Query: 71  NIIAEVAKNEF-MRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVD 129
           + +++V+K+   +    V+A +   ++  L  KD+ V       +  I   + E    V 
Sbjct: 231 SALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVV 290

Query: 130 QAGGAQIVIDHLRS 143
            AGG   VID + S
Sbjct: 291 NAGGVAAVIDCIGS 304



 Score = 31.6 bits (70), Expect = 2.2
 Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 470 LSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDL 529
           LS + +HS   ++ +T+V +G + HL  M  +    ++++ L AL+ ++   +  AE  +
Sbjct: 191 LSDIAKHSP--ELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVV 248

Query: 530 ESAKLVQILHRLLADERSAPEIKYNSMVLI 559
           E A++  ++   L D+     +K N+  LI
Sbjct: 249 E-AEIFPVVLTCLKDKDE--YVKKNASTLI 275


>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 37.0 bits (84), Expect = 0.053
 Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 24/170 (14%)

Query: 31  LLQALAQNNTETSEKIQASGILQLFASLLTPQS----SCKAKVANIIAEVAKNEFMRIPC 86
           +L+ L+  ++     ++A G+  L   L  P      +C   + N+     K E M    
Sbjct: 343 VLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGME--- 399

Query: 87  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLC- 145
              GL+  LVQLL S D  V+      L N+  ++++ +  V Q GG + ++  +     
Sbjct: 400 ---GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGD 456

Query: 146 --SITDPANEKLLTVFCGMLMNYSNENDSLQAQ---LINMGVIPTLVKLL 190
              IT+PA        C +    S   ++  AQ    ++ G +P +VKLL
Sbjct: 457 REDITEPA-------ICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLL 498



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 95/422 (22%), Positives = 160/422 (37%), Gaps = 61/422 (14%)

Query: 89  AGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSIT 148
           AG +  +V LLN  + + L  T   L  + Y + E +  +  +GG Q +++ +R+     
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---- 331

Query: 149 DPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAA--LTEMCLVA 206
               EKLL     +L   S  + +  A +   G     ++ LG+H  + +  L + CL  
Sbjct: 332 --TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG-----MQALGLHLTDPSQRLVQNCLWT 384

Query: 207 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-AENDAIKLQLVEA 265
             NL++  + +E      +   LV+L     + +       +L+ L   N   K+ + + 
Sbjct: 385 LRNLSDAATKQE--GMEGLLGTLVQLLGSD-DINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 266 GLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQR---- 321
           G +E L+  V +  D    +DITE        +  L    S  +  E  + +V       
Sbjct: 442 GGIEALVRTVLRAGD---REDITE------PAICALRHLTSRHQEAEMAQNAVRLHYGLP 492

Query: 322 --VLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVED------ 373
             V    P ++  L  A    I N A   AN   + + G + +L+ LL R  +D      
Sbjct: 493 VVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTS 552

Query: 374 -GNVTVQ-----------HAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 421
            G    Q                AL  LA  V N+  +         ++ L S +  +Q 
Sbjct: 553 MGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQR 612

Query: 422 KLLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSK 478
              G L  L   +EAAE +   G    L E L        H+   G +    + L R S+
Sbjct: 613 VAAGVLCELAQDKEAAEAIEAEGATAPLTELL--------HSRNEGVATYAAAVLFRMSE 664

Query: 479 SK 480
            K
Sbjct: 665 DK 666



 Score = 30.0 bits (66), Expect = 6.4
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 10/113 (8%)

Query: 79  NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVI 138
           N+  ++  + +G    LV ++ +   E LL T   +  +       + A+ +AGG Q + 
Sbjct: 308 NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALG 367

Query: 139 DHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 191
            HL      TDP+    L   C  L    N +D+   Q    G++ TLV+LLG
Sbjct: 368 LHL------TDPSQR--LVQNC--LWTLRNLSDAATKQEGMEGLLGTLVQLLG 410


>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 37.0 bits (84), Expect = 0.053
 Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 24/170 (14%)

Query: 31  LLQALAQNNTETSEKIQASGILQLFASLLTPQS----SCKAKVANIIAEVAKNEFMRIPC 86
           +L+ L+  ++     ++A G+  L   L  P      +C   + N+     K E M    
Sbjct: 343 VLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGME--- 399

Query: 87  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLC- 145
              GL+  LVQLL S D  V+      L N+  ++++ +  V Q GG + ++  +     
Sbjct: 400 ---GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGD 456

Query: 146 --SITDPANEKLLTVFCGMLMNYSNENDSLQAQ---LINMGVIPTLVKLL 190
              IT+PA        C +    S   ++  AQ    ++ G +P +VKLL
Sbjct: 457 REDITEPA-------ICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLL 498



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 95/422 (22%), Positives = 160/422 (37%), Gaps = 61/422 (14%)

Query: 89  AGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSIT 148
           AG +  +V LLN  + + L  T   L  + Y + E +  +  +GG Q +++ +R+     
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---- 331

Query: 149 DPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAA--LTEMCLVA 206
               EKLL     +L   S  + +  A +   G     ++ LG+H  + +  L + CL  
Sbjct: 332 --TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG-----MQALGLHLTDPSQRLVQNCLWT 384

Query: 207 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-AENDAIKLQLVEA 265
             NL++  + +E      +   LV+L     + +       +L+ L   N   K+ + + 
Sbjct: 385 LRNLSDAATKQE--GMEGLLGTLVQLLGSD-DINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 266 GLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQR---- 321
           G +E L+  V +  D    +DITE        +  L    S  +  E  + +V       
Sbjct: 442 GGIEALVRTVLRAGD---REDITE------PAICALRHLTSRHQEAEMAQNAVRLHYGLP 492

Query: 322 --VLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVED------ 373
             V    P ++  L  A    I N A   AN   + + G + +L+ LL R  +D      
Sbjct: 493 VVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTS 552

Query: 374 -GNVTVQ-----------HAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 421
            G    Q                AL  LA  V N+  +         ++ L S +  +Q 
Sbjct: 553 MGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQR 612

Query: 422 KLLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSK 478
              G L  L   +EAAE +   G    L E L        H+   G +    + L R S+
Sbjct: 613 VAAGVLCELAQDKEAAEAIEAEGATAPLTELL--------HSRNEGVATYAAAVLFRMSE 664

Query: 479 SK 480
            K
Sbjct: 665 DK 666



 Score = 30.0 bits (66), Expect = 6.4
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 10/113 (8%)

Query: 79  NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVI 138
           N+  ++  + +G    LV ++ +   E LL T   +  +       + A+ +AGG Q + 
Sbjct: 308 NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALG 367

Query: 139 DHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 191
            HL      TDP+    L   C  L    N +D+   Q    G++ TLV+LLG
Sbjct: 368 LHL------TDPSQR--LVQNC--LWTLRNLSDAATKQEGMEGLLGTLVQLLG 410


>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 37.0 bits (84), Expect = 0.053
 Identities = 42/170 (24%), Positives = 73/170 (42%), Gaps = 24/170 (14%)

Query: 31  LLQALAQNNTETSEKIQASGILQLFASLLTPQS----SCKAKVANIIAEVAKNEFMRIPC 86
           +L+ L+  ++     ++A G+  L   L  P      +C   + N+     K E M    
Sbjct: 343 VLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGME--- 399

Query: 87  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLC- 145
              GL+  LVQLL S D  V+      L N+  ++++ +  V Q GG + ++  +     
Sbjct: 400 ---GLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGD 456

Query: 146 --SITDPANEKLLTVFCGMLMNYSNENDSLQAQ---LINMGVIPTLVKLL 190
              IT+PA        C +    S   ++  AQ    ++ G +P +VKLL
Sbjct: 457 REDITEPA-------ICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLL 498



 Score = 34.7 bits (78), Expect = 0.26
 Identities = 95/422 (22%), Positives = 160/422 (37%), Gaps = 61/422 (14%)

Query: 89  AGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSIT 148
           AG +  +V LLN  + + L  T   L  + Y + E +  +  +GG Q +++ +R+     
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTY---- 331

Query: 149 DPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAA--LTEMCLVA 206
               EKLL     +L   S  + +  A +   G     ++ LG+H  + +  L + CL  
Sbjct: 332 --TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG-----MQALGLHLTDPSQRLVQNCLWT 384

Query: 207 FGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-AENDAIKLQLVEA 265
             NL++  + +E      +   LV+L     + +       +L+ L   N   K+ + + 
Sbjct: 385 LRNLSDAATKQE--GMEGLLGTLVQLLGSD-DINVVTCAAGILSNLTCNNYKNKMMVCQV 441

Query: 266 GLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQR---- 321
           G +E L+  V +  D    +DITE        +  L    S  +  E  + +V       
Sbjct: 442 GGIEALVRTVLRAGD---REDITE------PAICALRHLTSRHQEAEMAQNAVRLHYGLP 492

Query: 322 --VLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVED------ 373
             V    P ++  L  A    I N A   AN   + + G + +L+ LL R  +D      
Sbjct: 493 VVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTS 552

Query: 374 -GNVTVQ-----------HAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQF 421
            G    Q                AL  LA  V N+  +         ++ L S +  +Q 
Sbjct: 553 MGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQR 612

Query: 422 KLLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSK 478
              G L  L   +EAAE +   G    L E L        H+   G +    + L R S+
Sbjct: 613 VAAGVLCELAQDKEAAEAIEAEGATAPLTELL--------HSRNEGVATYAAAVLFRMSE 664

Query: 479 SK 480
            K
Sbjct: 665 DK 666



 Score = 30.0 bits (66), Expect = 6.4
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 10/113 (8%)

Query: 79  NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVI 138
           N+  ++  + +G    LV ++ +   E LL T   +  +       + A+ +AGG Q + 
Sbjct: 308 NQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALG 367

Query: 139 DHLRSLCSITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLG 191
            HL      TDP+    L   C  L    N +D+   Q    G++ TLV+LLG
Sbjct: 368 LHL------TDPSQR--LVQNC--LWTLRNLSDAATKQEGMEGLLGTLVQLLG 410


>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
          Length = 1363

 Score = 36.2 bits (82), Expect = 0.090
 Identities = 91/447 (20%), Positives = 183/447 (40%), Gaps = 65/447 (14%)

Query: 170  NDSLQAQLINMGVIPTLVKLL-----GIHCQNAALTEMCLVAFGNLAELESSKEQFASTN 224
            ND     +++ G IP L+ LL      + C+   L         N++  +S+        
Sbjct: 660  NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL-------LSNISTHKSAVHALVEAG 712

Query: 225  IAEELVKLF--KKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSD 282
                L+ L    +   H +  +I   +A     D I     +   +  L+ ++   +++ 
Sbjct: 713  GIPSLINLLVCDEPEVHSRCAVILYDIAQCENKDVI----AKYNGIPSLINLLNLNIEN- 767

Query: 283  KEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIA 342
                   L    + + +L +G+E+ Q+     KG  +  ++ ++ S++  L+   + AIA
Sbjct: 768  ------VLVNVMNCIRVLCIGNENNQRAVREHKGLPY--LIRFLSSDSDVLKAVSSAAIA 819

Query: 343  NFARNDANCIHMVD-NGIVEKLMDLLDRHVEDGNVTVQHAALSALRNLAI--PVINKAKM 399
               R++      +   G +  L+ L     +   ++VQ     A+ +LA    +I KA  
Sbjct: 820  EVGRDNKEIQDAIAMEGAIPPLVALF----KGKQISVQMKGAMAVESLASHNALIQKA-F 874

Query: 400  LSAGVTEAVLKFLKSEMPPVQ-------FKLLGTLRMLIDAQEAAEQLGKNVKLVERLVE 452
            L   +T+ +LK LK+    V+       + L G  + L   +  AEQ+G +  ++  L+ 
Sbjct: 875  LEKSLTKYLLKLLKAFQIDVKEQGAVALWALAG--QTLKQQKYMAEQIGYSF-IINMLLS 931

Query: 453  WCEAKDHAGVMGESNRLLSALIRHSKSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALV 512
                  + G  GE+   LS   R  +++     I +  GI  LV +      I +   L 
Sbjct: 932  PSAKMQYVG--GEAVIALSKDSRMHQNQ-----ICEGNGIAPLVRLLRIS-TIAEGTLLS 983

Query: 513  ALALIAALELGTA-------EKDLESAKLVQILHRLLADERSAPEIKYN-SMVLICALMG 564
             +  + ++ +G A       ++ +       +L +LL +  S P IK   +  L C ++G
Sbjct: 984  VIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPS-PNIKVEVAFSLACIVLG 1042

Query: 565  SECLHKEVQD---LAFLDVVSKLRSHE 588
            ++ L K++ +     + DV+  L S E
Sbjct: 1043 NDVLQKDLHENEGFEYADVLYLLHSTE 1069


>gi|7106299 ataxin 10 [Homo sapiens]
          Length = 475

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 40/187 (21%), Positives = 80/187 (42%), Gaps = 18/187 (9%)

Query: 12  LKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLLTPQSSCKAKVAN 71
           LK+ + +  +D        LL  L +    T    +  G LQ+F  LL        +V +
Sbjct: 287 LKLASEEPPDDEEALATIRLLDVLCEMTVNT----ELLGYLQVFPGLLERVIDL-LRVIH 341

Query: 72  IIAEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQA 131
           +  +   N F    CV A     +  + N     ++    R +GN+CY + + +  V++ 
Sbjct: 342 VAGKETTNIFSNCGCVRAE--GDISNVANGFKSHLI----RLIGNLCYKNKDNQDKVNEL 395

Query: 132 GGAQIVIDHLRSLCSITD--PANEKLLTVFCGMLMNYSNENDSLQAQLINMGVI-PTLVK 188
            G  +++D+    C+I+D  P   + +      L   +++N  L A++   G+   +L+K
Sbjct: 396 DGIPLILDN----CNISDSNPFLTQWVIYAIRNLTEDNSQNQDLIAKMEEQGLADASLLK 451

Query: 189 LLGIHCQ 195
            +G   +
Sbjct: 452 KVGFEVE 458


>gi|4504901 karyopherin alpha 4 [Homo sapiens]
          Length = 521

 Score = 35.4 bits (80), Expect = 0.15
 Identities = 83/382 (21%), Positives = 147/382 (38%), Gaps = 51/382 (13%)

Query: 35  LAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANIIAEVAKNEFMRIPCVDAGLI 92
           L+ +     + +  SGIL +    L      S + + A  +  +A     +   V     
Sbjct: 99  LSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNA 158

Query: 93  SPL-VQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAG---------GAQIVIDHLR 142
            PL ++LL+S  Q V  Q   ALGNI  D  + R  V   G            I I  LR
Sbjct: 159 VPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLR 218

Query: 143 S-------LCSITDPAN-----EKLLTVFCGML--------------MNYSNENDSLQAQ 176
           +       LC   DP       +++L   C ++              ++Y  +  + Q Q
Sbjct: 219 NVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQ 278

Query: 177 L-INMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFA-STNIAEELVKLFK 234
           + I+ G++P LV LL    Q   +    L A GN+      + Q   + +       L  
Sbjct: 279 MVIDSGIVPHLVPLLS--HQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLT 336

Query: 235 KQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGS 294
              E   +E ++ +    A N      +++A LV  ++ ++      DK D  T+ +   
Sbjct: 337 HPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLL------DKGDFGTQKEAAW 390

Query: 295 DLMVLLLLG-DESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCI- 352
            +  L + G  + +  L +      F  +L+   +   Q+ L G   I   A ++A  I 
Sbjct: 391 AISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIG 450

Query: 353 HMVDN-GIVEKLMDLLDRHVED 373
           ++++  G +EK+  L +   ED
Sbjct: 451 NLIEECGGLEKIEQLQNHENED 472


>gi|222144293 karyopherin alpha 1 [Homo sapiens]
          Length = 538

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 7/104 (6%)

Query: 87  VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCS 146
           +DAG+   LV+LL   D +V+    RA+GNI        +  D      +    L+SL  
Sbjct: 293 IDAGVCRRLVELLMHNDYKVVSPALRAVGNIV-------TGDDIQTQVILNCSALQSLLH 345

Query: 147 ITDPANEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLL 190
           +     E +    C  + N +  N +    +I+  + P L+ +L
Sbjct: 346 LLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISIL 389


>gi|146231975 catenin, delta 1 isoform 3A [Homo sapiens]
          Length = 832

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 163 LMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAS 222
           L +    ND ++  +  +  IP LV LL     +    E+ L A G L  +   ++Q   
Sbjct: 289 LQHLCYRNDKVKTDVRKLKGIPVLVGLL-----DHPKKEVHLGACGALKNISFGRDQDNK 343

Query: 223 TNIAE-----ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIV 275
             I        LV+L +K  + D  E+I   L  L+ +D+IK+++V+  L     E++
Sbjct: 344 IAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVI 401


>gi|146231948 catenin, delta 1 isoform 3A [Homo sapiens]
          Length = 832

 Score = 33.9 bits (76), Expect = 0.45
 Identities = 31/118 (26%), Positives = 54/118 (45%), Gaps = 10/118 (8%)

Query: 163 LMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFAS 222
           L +    ND ++  +  +  IP LV LL     +    E+ L A G L  +   ++Q   
Sbjct: 289 LQHLCYRNDKVKTDVRKLKGIPVLVGLL-----DHPKKEVHLGACGALKNISFGRDQDNK 343

Query: 223 TNIAE-----ELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIV 275
             I        LV+L +K  + D  E+I   L  L+ +D+IK+++V+  L     E++
Sbjct: 344 IAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVI 401


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,637,528
Number of Sequences: 37866
Number of extensions: 714142
Number of successful extensions: 2320
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 2165
Number of HSP's gapped (non-prelim): 134
length of query: 607
length of database: 18,247,518
effective HSP length: 108
effective length of query: 499
effective length of database: 14,157,990
effective search space: 7064837010
effective search space used: 7064837010
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.