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Search of human proteins with 154813195
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
(1009 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 2028 0.0
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 867 0.0
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 867 0.0
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 785 0.0
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 689 0.0
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 387 e-107
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 162 1e-39
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 162 1e-39
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 148 3e-35
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 143 7e-34
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 130 8e-30
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 88 4e-17
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 86 2e-16
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 86 2e-16
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 81 4e-15
gi|29788755 SET binding factor 2 [Homo sapiens] 77 8e-14
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 71 6e-12
gi|239735519 SET binding factor 1 [Homo sapiens] 70 8e-12
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 69 2e-11
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 67 1e-10
gi|209863002 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|209862998 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|209862994 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|18860873 MAP-kinase activating death domain-containing protei... 58 4e-08
gi|209862987 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|209862983 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|209862979 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|209862975 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|209862971 MAP-kinase activating death domain-containing prote... 58 4e-08
gi|209571517 MAP-kinase activating death domain-containing prote... 58 4e-08
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 2028 bits (5254), Expect = 0.0
Identities = 1009/1009 (100%), Positives = 1009/1009 (100%)
Query: 1 MDMFSLDMIISDPAAEASRAGKKQLRGVQNPCPSARARPRHKSLNIKDKISEWEGKKEVP 60
MDMFSLDMIISDPAAEASRAGKKQLRGVQNPCPSARARPRHKSLNIKDKISEWEGKKEVP
Sbjct: 1 MDMFSLDMIISDPAAEASRAGKKQLRGVQNPCPSARARPRHKSLNIKDKISEWEGKKEVP 60
Query: 61 TPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTESTEKERNKGAVNVGGQ 120
TPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTESTEKERNKGAVNVGGQ
Sbjct: 61 TPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTESTEKERNKGAVNVGGQ 120
Query: 121 DPEPGQDLSQPEREVDPSWGRGREPRLGKLRFQNDPLSVLKQVKKLEQALKDGSAGLDPQ 180
DPEPGQDLSQPEREVDPSWGRGREPRLGKLRFQNDPLSVLKQVKKLEQALKDGSAGLDPQ
Sbjct: 121 DPEPGQDLSQPEREVDPSWGRGREPRLGKLRFQNDPLSVLKQVKKLEQALKDGSAGLDPQ 180
Query: 181 LPGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVHPSDLEGREPTPELVEDRKGSCR 240
LPGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVHPSDLEGREPTPELVEDRKGSCR
Sbjct: 181 LPGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVHPSDLEGREPTPELVEDRKGSCR 240
Query: 241 RPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLP 300
RPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLP
Sbjct: 241 RPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLP 300
Query: 301 SLPPPPLPSSPPPSSVNRRLWTGRQKSSADHRKSYEFEDLLQSSSESSRVDWYAQTKLGL 360
SLPPPPLPSSPPPSSVNRRLWTGRQKSSADHRKSYEFEDLLQSSSESSRVDWYAQTKLGL
Sbjct: 301 SLPPPPLPSSPPPSSVNRRLWTGRQKSSADHRKSYEFEDLLQSSSESSRVDWYAQTKLGL 360
Query: 361 TRTLSEENVYEDILDPPMKENPYEDIELHGRCLGKKCVLNFPASPTSSIPDTLTKQSLSK 420
TRTLSEENVYEDILDPPMKENPYEDIELHGRCLGKKCVLNFPASPTSSIPDTLTKQSLSK
Sbjct: 361 TRTLSEENVYEDILDPPMKENPYEDIELHGRCLGKKCVLNFPASPTSSIPDTLTKQSLSK 420
Query: 421 PAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDIFFNLGDPQNGRKKRKI 480
PAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDIFFNLGDPQNGRKKRKI
Sbjct: 421 PAFFRQNSERRNFKLLDTRKLSRDGTGSPSKISPPSTPSSPDDIFFNLGDPQNGRKKRKI 480
Query: 481 PKLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVK 540
PKLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVK
Sbjct: 481 PKLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVK 540
Query: 541 SRLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKF 600
SRLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKF
Sbjct: 541 SRLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKF 600
Query: 601 MREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKR 660
MREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKR
Sbjct: 601 MREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKR 660
Query: 661 LPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFL 720
LPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFL
Sbjct: 661 LPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFL 720
Query: 721 PGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSK 780
PGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSK
Sbjct: 721 PGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSK 780
Query: 781 CCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVD 840
CCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVD
Sbjct: 781 CCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVD 840
Query: 841 LVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVS 900
LVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVS
Sbjct: 841 LVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVS 900
Query: 901 EAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQ 960
EAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQ
Sbjct: 901 EAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQ 960
Query: 961 ERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK 1009
ERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK
Sbjct: 961 ERELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK 1009
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 867 bits (2240), Expect = 0.0
Identities = 514/1008 (50%), Positives = 662/1008 (65%), Gaps = 59/1008 (5%)
Query: 36 RARPRHKSLNIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEA 95
R R SL I++KIS WEG++E +P S + +E S E +S+G + +
Sbjct: 154 RTGTRAHSLGIREKISAWEGRREA-SPRMSMCGEKRE----GSGSEWAASEGCPSLGCPS 208
Query: 96 KNGMRPGTESTEKERN-KGAVNVGGQDPEPGQDLSQPEREVDP---SWGRGREPRLGKLR 151
+ P S+EK + KG + E ++ E E P S+ R E RLG+
Sbjct: 209 ---VVPSPCSSEKTFDFKGLRRMSRTFSECSYPETEEEGEALPVRDSFYR-LEKRLGRSE 264
Query: 152 ---------FQNDPLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCPPDKAEAGSTLP 202
+ + +VL +++K+EQ LK+ PQLP +CYS K +L
Sbjct: 265 PSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGLPQLPSSCYSVDRGKRKTGTLGSLE 324
Query: 203 ENLGGGSGSEVSQRVHPSDLEGRE-PTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKP 261
E GG S S S+ V + + G P PE + GS + + + R S P
Sbjct: 325 EPAGGASVSAGSRAVGVAGVAGEAGPPPE--REGSGSTKPGTPGNSPSSQRLPSKSSLDP 382
Query: 262 FINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLPS-LPPPPLPSSPPPSSVNRRL 320
+NP+PKP+RTF++ + + KP G LPP P+ PPPLPS+P P R
Sbjct: 383 AVNPVPKPKRTFEYEADKNPKSKPSNG-------LPPSPTPAAPPPLPSTPAPPVTRRPK 435
Query: 321 WTGRQKSSADHRKSYEFEDL--LQSSSESSRVD--WYAQTKLGLTRTLSEENVYEDILDP 376
R + RKS+EFED LQS SS + Q K G TL EEN YEDI+
Sbjct: 436 KDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTL-EENAYEDIVGD 494
Query: 377 PMKENPYEDIELHGRCLGKKCV---------LNFPASPT----SSIPDTLTKQSLSKPAF 423
KENPYED++L R G+K L+ SP +S P L+ + S+
Sbjct: 495 LPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLR 554
Query: 424 FRQNSERRNFKLLDTRKL-SRDGTGSPSKISPPSTPSS-PDDIFFNLGDPQNGRKKRKIP 481
SER++ +L K S D +++S PS+PSS +D + + R+ R+IP
Sbjct: 555 SGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIP 614
Query: 482 KLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKS 541
KLV RIN+IY +RGKKR+K+LS S + + DENSES+SD++++ KAH+QRLV+++S
Sbjct: 615 KLVQRINSIYNAKRGKKRLKKLSMS-SIETASLRDENSESESDSDDRFKAHTQRLVHIQS 673
Query: 542 RLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFM 601
LK+AP Y +L EL+E+QER+LFEYFVVVSL KK + Y+PE++ QFP KL+R K M
Sbjct: 674 MLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFP-KLDRPTKQM 732
Query: 602 REAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRL 661
REAE++LKAIPQFCFPDAKDW+PV +++SETFSF+LTGEDGSRRFGYCRRLLP GKG RL
Sbjct: 733 REAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRL 792
Query: 662 PEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLP 721
PEVYC++SRLGCF LFS++LDEVE+RRGIS ALV P MRS+ME+PFPA GKTI VK FLP
Sbjct: 793 PEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLP 852
Query: 722 GSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKC 781
G+G EV+EL RP+DSRLEHVDFE LF+ LSVR L+ +FASLLLERRVIF+ADKLS LS C
Sbjct: 853 GAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSC 912
Query: 782 CHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDL 841
HA+VAL+YPF+WQHT+IPVLP +M+DIVC PTPFL+GLLSSSLP L+ELP+EE L+V+L
Sbjct: 913 SHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNL 972
Query: 842 VNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSE 901
+ RF+RQMDDED++LPRKLQ ALE LE++NEL + + D E + LN +VSE
Sbjct: 973 GSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSD----DECNTLNGLVSE 1028
Query: 902 AFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961
F+RFFVE VGHYSLFLT E+ ER QREAFRK+V+SKS+R FLEVFME+QMF GFIQ+
Sbjct: 1029 VFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQD 1088
Query: 962 RELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK 1009
RELR+ AKGLFE R ++YLE LP E SG+NKFL+GLGNKMKFLHKK
Sbjct: 1089 RELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKK 1136
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 867 bits (2240), Expect = 0.0
Identities = 514/1008 (50%), Positives = 662/1008 (65%), Gaps = 59/1008 (5%)
Query: 36 RARPRHKSLNIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEA 95
R R SL I++KIS WEG++E +P S + +E S E +S+G + +
Sbjct: 154 RTGTRAHSLGIREKISAWEGRREA-SPRMSMCGEKRE----GSGSEWAASEGCPSLGCPS 208
Query: 96 KNGMRPGTESTEKERN-KGAVNVGGQDPEPGQDLSQPEREVDP---SWGRGREPRLGKLR 151
+ P S+EK + KG + E ++ E E P S+ R E RLG+
Sbjct: 209 ---VVPSPCSSEKTFDFKGLRRMSRTFSECSYPETEEEGEALPVRDSFYR-LEKRLGRSE 264
Query: 152 ---------FQNDPLSVLKQVKKLEQALKDGSAGLDPQLPGTCYSPHCPPDKAEAGSTLP 202
+ + +VL +++K+EQ LK+ PQLP +CYS K +L
Sbjct: 265 PSAFLRGHGSRKESSAVLSRIQKIEQVLKEQPGRGLPQLPSSCYSVDRGKRKTGTLGSLE 324
Query: 203 ENLGGGSGSEVSQRVHPSDLEGRE-PTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKP 261
E GG S S S+ V + + G P PE + GS + + + R S P
Sbjct: 325 EPAGGASVSAGSRAVGVAGVAGEAGPPPE--REGSGSTKPGTPGNSPSSQRLPSKSSLDP 382
Query: 262 FINPLPKPRRTFKHAGEGDKDGKPGIGFRKEKRNLPPLPS-LPPPPLPSSPPPSSVNRRL 320
+NP+PKP+RTF++ + + KP G LPP P+ PPPLPS+P P R
Sbjct: 383 AVNPVPKPKRTFEYEADKNPKSKPSNG-------LPPSPTPAAPPPLPSTPAPPVTRRPK 435
Query: 321 WTGRQKSSADHRKSYEFEDL--LQSSSESSRVD--WYAQTKLGLTRTLSEENVYEDILDP 376
R + RKS+EFED LQS SS + Q K G TL EEN YEDI+
Sbjct: 436 KDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTL-EENAYEDIVGD 494
Query: 377 PMKENPYEDIELHGRCLGKKCV---------LNFPASPT----SSIPDTLTKQSLSKPAF 423
KENPYED++L R G+K L+ SP +S P L+ + S+
Sbjct: 495 LPKENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLR 554
Query: 424 FRQNSERRNFKLLDTRKL-SRDGTGSPSKISPPSTPSS-PDDIFFNLGDPQNGRKKRKIP 481
SER++ +L K S D +++S PS+PSS +D + + R+ R+IP
Sbjct: 555 SGNWSERKSHRLPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIP 614
Query: 482 KLVLRINAIYEVRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKS 541
KLV RIN+IY +RGKKR+K+LS S + + DENSES+SD++++ KAH+QRLV+++S
Sbjct: 615 KLVQRINSIYNAKRGKKRLKKLSMS-SIETASLRDENSESESDSDDRFKAHTQRLVHIQS 673
Query: 542 RLKQAPRYPSLARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFM 601
LK+AP Y +L EL+E+QER+LFEYFVVVSL KK + Y+PE++ QFP KL+R K M
Sbjct: 674 MLKRAPSYRTLELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFP-KLDRPTKQM 732
Query: 602 REAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRL 661
REAE++LKAIPQFCFPDAKDW+PV +++SETFSF+LTGEDGSRRFGYCRRLLP GKG RL
Sbjct: 733 REAEERLKAIPQFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRL 792
Query: 662 PEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLP 721
PEVYC++SRLGCF LFS++LDEVE+RRGIS ALV P MRS+ME+PFPA GKTI VK FLP
Sbjct: 793 PEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLP 852
Query: 722 GSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKC 781
G+G EV+EL RP+DSRLEHVDFE LF+ LSVR L+ +FASLLLERRVIF+ADKLS LS C
Sbjct: 853 GAGNEVLELRRPMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSC 912
Query: 782 CHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDL 841
HA+VAL+YPF+WQHT+IPVLP +M+DIVC PTPFL+GLLSSSLP L+ELP+EE L+V+L
Sbjct: 913 SHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNL 972
Query: 842 VNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSE 901
+ RF+RQMDDED++LPRKLQ ALE LE++NEL + + D E + LN +VSE
Sbjct: 973 GSDRFIRQMDDEDTLLPRKLQAALEQALERKNELISQDSDSDSD----DECNTLNGLVSE 1028
Query: 902 AFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961
F+RFFVE VGHYSLFLT E+ ER QREAFRK+V+SKS+R FLEVFME+QMF GFIQ+
Sbjct: 1029 VFIRFFVETVGHYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQD 1088
Query: 962 RELRRQDAKGLFEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK 1009
RELR+ AKGLFE R ++YLE LP E SG+NKFL+GLGNKMKFLHKK
Sbjct: 1089 RELRKCRAKGLFEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKK 1136
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapiens]
Length = 717
Score = 785 bits (2026), Expect = 0.0
Identities = 422/697 (60%), Positives = 524/697 (75%), Gaps = 26/697 (3%)
Query: 332 RKSYEFEDL--LQSSSESSRVD--WYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIE 387
RKS+EFED LQS SS + Q K G TL EEN YEDI+ KENPYED++
Sbjct: 27 RKSFEFEDASSLQSLYPSSPTENGTENQPKFGSKSTL-EENAYEDIVGDLPKENPYEDVD 85
Query: 388 LHGRCLGKKCV---------LNFPASPT----SSIPDTLTKQSLSKPAFFRQNSERRNFK 434
L R G+K L+ SP +S P L+ + S+ SER++ +
Sbjct: 86 LKSRRAGRKSQQLSENSLDSLHRMWSPQDRKYNSPPTQLSLKPNSQSLRSGNWSERKSHR 145
Query: 435 LLDTRKL-SRDGTGSPSKISPPSTPSS-PDDIFFNLGDPQNGRKKRKIPKLVLRINAIYE 492
L K S D +++S PS+PSS +D + + R+ R+IPKLV RIN+IY
Sbjct: 146 LPRLPKRHSHDDMLLLAQLSLPSSPSSLNEDSLSTTSELLSSRRARRIPKLVQRINSIYN 205
Query: 493 VRRGKKRVKRLSQSMESNSGKVTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSL 552
+RGKKR+K+LS S + + DENSES+SD++++ KAH+QRLV+++S LK+AP Y +L
Sbjct: 206 AKRGKKRLKKLSMS-SIETASLRDENSESESDSDDRFKAHTQRLVHIQSMLKRAPSYRTL 264
Query: 553 ARELIEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIP 612
EL+E+QER+LFEYFVVVSL KK + Y+PE++ QFP KL+R K MREAE++LKAIP
Sbjct: 265 ELELLEWQERELFEYFVVVSLKKKPSRNTYLPEVSYQFP-KLDRPTKQMREAEERLKAIP 323
Query: 613 QFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLG 672
QFCFPDAKDW+PV +++SETFSF+LTGEDGSRRFGYCRRLLP GKG RLPEVYC++SRLG
Sbjct: 324 QFCFPDAKDWLPVSEYSSETFSFMLTGEDGSRRFGYCRRLLPSGKGPRLPEVYCVISRLG 383
Query: 673 CFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCR 732
CF LFS++LDEVE+RRGIS ALV P MRS+ME+PFPA GKTI VK FLPG+G EV+EL R
Sbjct: 384 CFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELRR 443
Query: 733 PLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPF 792
P+DSRLEHVDFE LF+ LSVR L+ +FASLLLERRVIF+ADKLS LS C HA+VAL+YPF
Sbjct: 444 PMDSRLEHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPF 503
Query: 793 AWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDD 852
+WQHT+IPVLP +M+DIVC PTPFL+GLLSSSLP L+ELP+EE L+V+L + RF+RQMDD
Sbjct: 504 SWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMDD 563
Query: 853 EDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVG 912
ED++LPRKLQ ALE LE++NEL + + D E + LN +VSE F+RFFVE VG
Sbjct: 564 EDTLLPRKLQAALEQALERKNELISQDSDSDSD----DECNTLNGLVSEVFIRFFVETVG 619
Query: 913 HYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGL 972
HYSLFLT E+ ER QREAFRK+V+SKS+R FLEVFME+QMF GFIQ+RELR+ AKGL
Sbjct: 620 HYSLFLTQSEKGERAFQREAFRKSVASKSIRRFLEVFMESQMFAGFIQDRELRKCRAKGL 679
Query: 973 FEVRAQEYLETLPSGEHSGVNKFLKGLGNKMKFLHKK 1009
FE R ++YLE LP E SG+NKFL+GLGNKMKFLHKK
Sbjct: 680 FEQRVEQYLEELPDTEQSGMNKFLRGLGNKMKFLHKK 716
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 689 bits (1777), Expect = 0.0
Identities = 431/983 (43%), Positives = 570/983 (57%), Gaps = 149/983 (15%)
Query: 45 NIKDKISEWEGKKEVPTPAPSRRADGQEDYLPSSTVERRSSDGVRTQVTEAKNGMRPGTE 104
NIK KIS+WEG+ + E + P R + ++ KN +
Sbjct: 20 NIKQKISQWEGR--------ANGISNPEKWCPKDFGVRYNC---HQEIRLKKNPIA---- 64
Query: 105 STEKERNKGAVNVGGQDPEPGQDLSQPEREVDPSWGRGREPRLGKLRF---QNDPLSVLK 161
ER ++V ++ G D+++ + D S ++ F +++ V
Sbjct: 65 ----ERKSKNLDVTSRE-NVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCS 119
Query: 162 QVKKLEQALKDGSAGLDPQL---PGTCYSPHCPPDKAEAGSTLPENLGGGSGSEVSQRVH 218
+VK++E +D LDP+ PG Y+ K EA P+ L ++ +
Sbjct: 120 RVKEIESCKEDV---LDPETSLPPGNFYTSQILWKKIEA--LPPDKL-------LNLALE 167
Query: 219 PSDLEGREPTPELVEDRKGSCRRPWDRSLENVYRGSEGSPTKPFINPLPKPRRTFKHAGE 278
D +E +++ G + SLEN+Y EG P INPLPKPRRTF++ E
Sbjct: 168 HCDSSEKELNFRVLDSSYGITK-----SLENIYSEPEGQECGPSINPLPKPRRTFRYLSE 222
Query: 279 GDKDGKPGIGFRKEK---RNLPPLPSLPPPPLPSS--PPPSSVNRRLWTGRQKSSADHRK 333
G+ KE+ + S L SS P P ++ GR K RK
Sbjct: 223 S------GVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKYGGKI-RGRSK-----RK 270
Query: 334 SYEFEDL---LQSSSESSRVDWYAQTKLGLTRTLSEENVYEDILDPPMKENPYEDIELHG 390
S+EFED+ +S++ R + + L T SE+N+YEDI+ P KENPYEDI
Sbjct: 271 SFEFEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYEDII-YPTKENPYEDI---- 325
Query: 391 RCLGKKCVLNFPASPTSSIPDTLTKQSLSKPAFFRQNSERRNFKLLDTRKLSRDGTGSPS 450
P +P + + P + S
Sbjct: 326 --------------PVQPLPMWRSPSAWKLPP-------------------------AKS 346
Query: 451 KISPPSTPSSPDDIFFNLGDPQNGRKKRKIPKLVLRINAIYEVRRGKKRVKRLSQSMESN 510
P DDIF + + G+KK K + S
Sbjct: 347 AFKAPKLVLKIDDIF----ESKRGKKKVK---------------------------LHSY 375
Query: 511 SGK----VTDENSESDSDTEEKLKAHSQRLVNVKSRLKQAPRYPSLARELIEYQERQLFE 566
+GK E S ++SD E K +RL ++ K+ P Y +L R+LIE QE+QLFE
Sbjct: 376 TGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFE 435
Query: 567 YFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVPVQ 626
FVVVSL KK +G +Y+P++ QQFP K + +K ++ E++LK IP+FCFPD+KDW+P
Sbjct: 436 LFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTS 495
Query: 627 QFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILDEVEK 686
+ SETFSFVLTGEDGSR FGYC++LLP GKGKRLPEVYC+VSRLGCF+LFS+ILDEVEK
Sbjct: 496 ELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEK 555
Query: 687 RRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESL 746
RR +SPALV P MRSVMEAPFPA G+TI VK++LPG+G E IELCRPLDSRLEHVDF+ L
Sbjct: 556 RREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCL 615
Query: 747 FSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAM 806
F LSV HL+ V ASLLLERRVIF+A+ LS LSKC HA+VA +YPF WQHTYIPVLP +M
Sbjct: 616 FKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASM 675
Query: 807 VDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALE 866
+DIVCSPTPFLIG+LS SLP L++LP+EEVL+VDL +FL+++ DED ILP KLQ AL
Sbjct: 676 IDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALM 735
Query: 867 HILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREER 926
ILE+RNE+ ++ ++ + LN +VSEAFVRFFVE+VGHYSL +T ER ER
Sbjct: 736 QILEERNEILTQE-------QNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGER 788
Query: 927 TLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQEYLETLPS 986
QRE FRK+ +S+S+RHFL++FMETQMF GFIQ+RELR+ KGLFE+RA +YLET+P
Sbjct: 789 VFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPE 848
Query: 987 GEHSGVNKFLKGLGNKMKFLHKK 1009
E SG+N+ L+ LG+KMKFL KK
Sbjct: 849 SEPSGMNRILRSLGSKMKFLQKK 871
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 387 bits (993), Expect = e-107
Identities = 204/423 (48%), Positives = 277/423 (65%), Gaps = 17/423 (4%)
Query: 562 RQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQL-KAIPQFCFPDAK 620
+ FEY +VVSL KK++ Y P +T QFP K E + +E E++L KAIP FCFPD
Sbjct: 51 QHFFEYLLVVSLKKKRSEDDYEPIITYQFP-KRENLLRGQQEEEERLLKAIPLFCFPDGN 109
Query: 621 DWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRI 680
+W + ++ ETFSFVLT DGSR+ GYCRRLLP G G RLP+VYCI+S +GCF LFS+I
Sbjct: 110 EWASLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKI 169
Query: 681 LDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEH 740
LDEVEKR IS A++ P M+ + EA FPA GKT+ +K+F+P SGTE I L RPLDS LEH
Sbjct: 170 LDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEH 229
Query: 741 VDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIP 800
VDF SL LS ++ +FAS +LER++IF+A+ LS LS+C HA AL+YPF+W HTYIP
Sbjct: 230 VDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIP 289
Query: 801 VLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRK 860
V+P +++ VC PTPF++G+ + + P+EEVL+V+L FL + DE ILP K
Sbjct: 290 VVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKDILPPK 349
Query: 861 LQ-VALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLT 919
LQ L+ + + NEL + +NE VS FV+FFV+IVGHY+ ++
Sbjct: 350 LQDDILDSLGQGINELKTAEQ--------------INEHVSGPFVQFFVKIVGHYASYIK 395
Query: 920 SGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQE 979
+ Q +F KA++SK+ R F++ F++TQ+F FIQE E + G F+ + E
Sbjct: 396 REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQKILE 455
Query: 980 YLE 982
Y E
Sbjct: 456 YEE 458
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 162 bits (410), Expect = 1e-39
Identities = 128/444 (28%), Positives = 212/444 (47%), Gaps = 55/444 (12%)
Query: 557 IEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQ--LKAIPQF 614
I+ FE +V V+ + + G PE+ +QFP + DQ L+ + +F
Sbjct: 5 IKQNPETTFEVYVEVA-YPRTGGTLSDPEVQRQFP----------EDYSDQEVLQTLTKF 53
Query: 615 CFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCF 674
CFP D + V Q + F+FVLT D +RFG+CR L G K +CI+S L F
Sbjct: 54 CFPFYVDSLTVSQ-VGQNFTFVLTDIDSKQRFGFCR-LSSGAKS-----CFCILSYLPWF 106
Query: 675 SLFSRIL----DEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIEL 730
+F ++L D KR+ L+ ++ + P P G ++ L +
Sbjct: 107 EVFYKLLNILADYTTKRQENQ---WNELLETLHKLPIPDPGVSV----HLSVHSYFTVPD 159
Query: 731 CRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIY 790
R L S E+ + F ++ V +++ ++AS+L ERR++ I KLS L+ C H A++Y
Sbjct: 160 TRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLY 219
Query: 791 PFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM 850
P WQH YIPVLPP ++D C+P P+LIG+ S + +R + L++V+++++ +
Sbjct: 220 PMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPF 279
Query: 851 DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEI 910
DD S LP + +L++ L++ S+ + V+ AF++
Sbjct: 280 DDLQS-LPNDVISSLKNRLKK-------------------VSTTTGDGVARAFLKAQAAF 319
Query: 911 VGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAK 970
G Y L E T EAF S ++R FL+ + Q+F+ FI R +
Sbjct: 320 FGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGE 379
Query: 971 GLFEVRAQEYLETLPSGEHSGVNK 994
G +V + E + GE++G +K
Sbjct: 380 GFSDV----FEEEINMGEYAGSDK 399
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 162 bits (410), Expect = 1e-39
Identities = 128/444 (28%), Positives = 212/444 (47%), Gaps = 55/444 (12%)
Query: 557 IEYQERQLFEYFVVVSLHKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQ--LKAIPQF 614
I+ FE +V V+ + + G PE+ +QFP + DQ L+ + +F
Sbjct: 5 IKQNPETTFEVYVEVA-YPRTGGTLSDPEVQRQFP----------EDYSDQEVLQTLTKF 53
Query: 615 CFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPGGKGKRLPEVYCIVSRLGCF 674
CFP D + V Q + F+FVLT D +RFG+CR L G K +CI+S L F
Sbjct: 54 CFPFYVDSLTVSQ-VGQNFTFVLTDIDSKQRFGFCR-LSSGAKS-----CFCILSYLPWF 106
Query: 675 SLFSRIL----DEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIEL 730
+F ++L D KR+ L+ ++ + P P G ++ L +
Sbjct: 107 EVFYKLLNILADYTTKRQENQ---WNELLETLHKLPIPDPGVSV----HLSVHSYFTVPD 159
Query: 731 CRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIY 790
R L S E+ + F ++ V +++ ++AS+L ERR++ I KLS L+ C H A++Y
Sbjct: 160 TRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLY 219
Query: 791 PFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM 850
P WQH YIPVLPP ++D C+P P+LIG+ S + +R + L++V+++++ +
Sbjct: 220 PMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLETPF 279
Query: 851 DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEI 910
DD S LP + +L++ L++ S+ + V+ AF++
Sbjct: 280 DDLQS-LPNDVISSLKNRLKK-------------------VSTTTGDGVARAFLKAQAAF 319
Query: 911 VGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAK 970
G Y L E T EAF S ++R FL+ + Q+F+ FI R +
Sbjct: 320 FGSYRNALKIEPEEPITFCEEAFVSHYRSGAMRQFLQNATQLQLFKQFIDGRLDLLNSGE 379
Query: 971 GLFEVRAQEYLETLPSGEHSGVNK 994
G +V + E + GE++G +K
Sbjct: 380 GFSDV----FEEEINMGEYAGSDK 399
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 148 bits (373), Expect = 3e-35
Identities = 119/401 (29%), Positives = 199/401 (49%), Gaps = 43/401 (10%)
Query: 598 FKFMREAEDQ--LKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPG 655
+KF + DQ L+++P+FCFP + V Q + F+FVLT + +RFG+CR L G
Sbjct: 33 WKFPEDFGDQEILQSVPKFCFPFDVERVSQNQ-VGQHFTFVLTDIESKQRFGFCR-LTSG 90
Query: 656 GKGKRLPEVYCIVSRLGCFSLFSRILDEVEKRRGISPALVQPL---MRSVMEAPFPALGK 712
G CI+S L F ++ ++L+ + ++ L L +RS+ P P
Sbjct: 91 GT-----ICLCILSYLPWFEVYYKLLNTLADY--LAKELENDLNETLRSLYNHPVPKANT 143
Query: 713 TILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLERRVIFIA 772
+ + +V L +SR + F ++ V +++ ++AS+L ERR++ I+
Sbjct: 144 PVNLSVHSYFIAPDVTGLPTIPESR----NLTEYFVAVDVNNMLQLYASMLHERRIVIIS 199
Query: 773 DKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELP 832
KLS L+ C H AL+YP WQH YIPVLPP ++D C+P P+LIG+ SS + ++
Sbjct: 200 SKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKS 259
Query: 833 LEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPES 892
LE+V++++ V++ L + + LP + AL++ L++ +S
Sbjct: 260 LEDVVMLN-VDTNTLESPFSDLNNLPSDVVSALKNKLKK-------------------QS 299
Query: 893 SPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSLRHFLEVFMET 952
+ + V+ AF+R + G Y L E T E+F K SS ++ FLE +
Sbjct: 300 TATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSS-VMKQFLETAINL 358
Query: 953 QMFRGFIQERELRRQDAKGLFEVRAQEYLETLPSGEHSGVN 993
Q+F+ FI R + +G +V + E + SG G N
Sbjct: 359 QLFKQFIDGRLAKLNAGRGFSDV----FEEEITSGGFCGGN 395
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 143 bits (361), Expect = 7e-34
Identities = 116/401 (28%), Positives = 195/401 (48%), Gaps = 47/401 (11%)
Query: 598 FKFMREAEDQ--LKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFGYCRRLLPG 655
+KF + DQ L+++P+FCFP + V Q + F+FVLT + +RFG+CR L G
Sbjct: 33 WKFPEDFGDQEILQSVPKFCFPFDVERVSQNQ-VGQHFTFVLTDIESKQRFGFCR-LTSG 90
Query: 656 GKGKRLPEVYCIVSRLGCFSLFSRILDEV-------------EKRRGIS----PALVQPL 698
G CI+S L F ++ ++L+ + E R + P P+
Sbjct: 91 GT-----ICLCILSYLPWFEVYYKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPV 145
Query: 699 MRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCV 758
SV + F A + + + L + L + E + F ++ V +++ +
Sbjct: 146 NLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQL 205
Query: 759 FASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLI 818
+AS+L ERR++ I+ KLS L+ C H AL+YP WQH YIPVLPP ++D C+P P+LI
Sbjct: 206 YASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLI 265
Query: 819 GLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALEHILEQRNELACE 878
G+ SS + ++ LE+V++++ V++ L + + LP + AL++ L++
Sbjct: 266 GIHSSLIERVKNKSLEDVVMLN-VDTNTLESPFSDLNNLPSDVVSALKNKLKK------- 317
Query: 879 QDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVS 938
+S+ + V+ AF+R + G Y L E T E+F K S
Sbjct: 318 ------------QSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRS 365
Query: 939 SKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQE 979
S ++ FLE + Q+F+ FI R + +G +V +E
Sbjct: 366 S-VMKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEE 405
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 130 bits (326), Expect = 8e-30
Identities = 111/415 (26%), Positives = 187/415 (45%), Gaps = 54/415 (13%)
Query: 584 PELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGS 643
P + +QFP ++ ++ +P+FCFP + P F+F LT G+
Sbjct: 29 PPILRQFPPDFRD--------QEAMQMVPKFCFPFDVEREPPSPAVQH-FTFALTDLAGN 79
Query: 644 RRFGYCRRLLPGGKGKRLPEVYCIVSRLGCFSLFSRILDEV-----EKRRGISPALVQPL 698
RRFG+CR L G L CI+S L F +F ++L+ V + + + L+Q L
Sbjct: 80 RRFGFCR--LRAGTQSCL----CILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNL 133
Query: 699 MRSVMEAPFPALGK------TILVKNFLP----GSGTEVIELCRPLDSRL----EHVDFE 744
+ + P ++G T+ +P G+ + P RL E+ +
Sbjct: 134 FQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLT 193
Query: 745 SLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPP 804
L +++ ++V +FA+LL ERRV+ A KLS L+ C HA AL+YP W+H IP LPP
Sbjct: 194 ELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPP 253
Query: 805 AMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVA 864
++D C+P P+LIG+ +S +RE LE+V+V+++ + +D ++ P + +
Sbjct: 254 HLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSL- 312
Query: 865 LEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGERE 924
+ + ++A EG VS F++ + G Y L +
Sbjct: 313 ---LRLRLRKVALAPGEG----------------VSRLFLKAQALLFGGYRDALVCSPGQ 353
Query: 925 ERTLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQE 979
T E F L+ F + Q+F+ FI+ R + +G + QE
Sbjct: 354 PVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQE 408
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 88.2 bits (217), Expect = 4e-17
Identities = 101/443 (22%), Positives = 183/443 (41%), Gaps = 81/443 (18%)
Query: 582 YVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFP---DAKDWVPVQQFTSETFS-FVL 637
Y EL ++P + +F +++P FC P + W ++ FS FVL
Sbjct: 211 YEAELLGRYPEEDNEAFPLP-------ESVPVFCLPMGATIECWPAQTKYPVPVFSTFVL 263
Query: 638 TGEDGSRRFGYCRRLLP---------------------------GGKGKRLPEVYCIVSR 670
TG G + +G + GG+ R ++SR
Sbjct: 264 TGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSR 323
Query: 671 LGCFSLFSRILDEVEKRRGISP---ALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEV 727
F F L + + P L + + PFP+ + ++ P
Sbjct: 324 WPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDN--- 380
Query: 728 IELCRPLDSRL--EHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAM 785
+ LC+P+ S L F L SL + + ++L E +++ + + +L+ C A+
Sbjct: 381 LLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEAL 440
Query: 786 VALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSR 845
V++I+P WQ YIP+ P + D++ +P PF++G+ SS L P +V+ VDL ++
Sbjct: 441 VSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDL--HDPPADVICVDL-DTN 497
Query: 846 FLRQMDDEDSILPRKLQ--------VALEHILEQRNE-LACEQDEGPLD----------G 886
L Q +++ + PR L L ++ +Q ++ ++E L+ G
Sbjct: 498 TLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCG 557
Query: 887 RHGPESSPLNEVVSEAFVRFFVEIVGHYSLFL-------TSGERE-ERTLQREAFRKAVS 938
R + L V AF+RF ++ Y +FL + G R+ + + F K+
Sbjct: 558 RR----ARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRE 613
Query: 939 SKSLRHFLEVFMETQMFRGFIQE 961
S + + ++ + TQMF FI+E
Sbjct: 614 RSSHKLYSQL-LHTQMFSQFIEE 635
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 85.5 bits (210), Expect = 2e-16
Identities = 101/412 (24%), Positives = 181/412 (43%), Gaps = 67/412 (16%)
Query: 609 KAIPQFCFP---DAKDWVPVQQFTSETFS-FVLTGEDGSRRFGYC--------------- 649
+++P FC P + W ++ FS FVLTG + +G
Sbjct: 228 ESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEK 287
Query: 650 RRLLPG-----GKGKRLPEVY-----CIVSRLGCFSLFSRILDEVEKRRGISPALVQPLM 699
+RLL G GK ++ C++S F F + L + R IS V P+
Sbjct: 288 QRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIE 346
Query: 700 RSVM----EAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRL--EHVDFESLFSSLSVR 753
+ + + PFP+ + ++ P + L +P+ S L F +L +L
Sbjct: 347 KHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPLSGGKFSTLLQNLGPE 403
Query: 754 HLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSP 813
+ V + + E +++ + + S+L+ A+V++I+PF W Y+P+ P A+ D++ +P
Sbjct: 404 NAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAP 463
Query: 814 TPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDS----ILPRK----LQVAL 865
PF++G+ S L P +V VD V++ + Q+ D+ + ILP+K L L
Sbjct: 464 CPFIVGIDSRYFDLYD--PPPDVSCVD-VDTNTISQIGDKKNVAWKILPKKPCKNLMNTL 520
Query: 866 EHILEQRNELACE-QDEGPL-------DGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLF 917
++ +Q +L +D+G + D G ++ + EAF+ F I+ Y +
Sbjct: 521 NNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSY 580
Query: 918 L---TSGEREERT-----LQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961
L T E T +AF ++ +S + F + +TQMF FI+E
Sbjct: 581 LRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQMFIRFIEE 631
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 85.5 bits (210), Expect = 2e-16
Identities = 101/412 (24%), Positives = 181/412 (43%), Gaps = 67/412 (16%)
Query: 609 KAIPQFCFP---DAKDWVPVQQFTSETFS-FVLTGEDGSRRFGYC--------------- 649
+++P FC P + W ++ FS FVLTG + +G
Sbjct: 228 ESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEK 287
Query: 650 RRLLPG-----GKGKRLPEVY-----CIVSRLGCFSLFSRILDEVEKRRGISPALVQPLM 699
+RLL G GK ++ C++S F F + L + R IS V P+
Sbjct: 288 QRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIE 346
Query: 700 RSVM----EAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRL--EHVDFESLFSSLSVR 753
+ + + PFP+ + ++ P + L +P+ S L F +L +L
Sbjct: 347 KHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPLSGGKFSTLLQNLGPE 403
Query: 754 HLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSP 813
+ V + + E +++ + + S+L+ A+V++I+PF W Y+P+ P A+ D++ +P
Sbjct: 404 NAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAP 463
Query: 814 TPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDS----ILPRK----LQVAL 865
PF++G+ S L P +V VD V++ + Q+ D+ + ILP+K L L
Sbjct: 464 CPFIVGIDSRYFDLYD--PPPDVSCVD-VDTNTISQIGDKKNVAWKILPKKPCKNLMNTL 520
Query: 866 EHILEQRNELACE-QDEGPL-------DGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLF 917
++ +Q +L +D+G + D G ++ + EAF+ F I+ Y +
Sbjct: 521 NNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSY 580
Query: 918 L---TSGEREERT-----LQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961
L T E T +AF ++ +S + F + +TQMF FI+E
Sbjct: 581 LRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQMFIRFIEE 631
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 81.3 bits (199), Expect = 4e-15
Identities = 88/395 (22%), Positives = 169/395 (42%), Gaps = 62/395 (15%)
Query: 622 WVPVQQFTSETFS-FVLTGEDGSRRFG--------YCRRLLPG----------------- 655
W P ++ FS FVLTG + +G Y R LL
Sbjct: 8 WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMV 67
Query: 656 GKGKRLPEVYCIVSRLGCFSLFSRILDEVEKRRGISP---ALVQPLMRSVMEAPFPALGK 712
K + C++S F F + L + K P + + + + PFP+ +
Sbjct: 68 SKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQR 127
Query: 713 TILVKNFLPGSGTEVIELCRPLDSRL--EHVDFESLFSSLSVRHLVCVFASLLLERRVIF 770
++ S + + L +P+ + L +F +L +L + + +LLE +++
Sbjct: 128 PRILVQL---SVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILL 184
Query: 771 IADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRE 830
+ + ++L+ A+VA+I+PF WQ YIP+ P ++ ++ +P PF++G+ S L
Sbjct: 185 HSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDL--H 242
Query: 831 LPLEEVLVVDLVNSRFLRQMDDEDSI----LPRK----LQVALEHILEQRNELACEQDEG 882
P ++V+ +DL ++ L D++ ++ LP+K L L+ + Q + + + EG
Sbjct: 243 DPPQDVVCIDL-DTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEG 301
Query: 883 ------PLDGRHG--PESSPLNEVVSEAFVRFFVEIVGHYSLFL--------TSGEREER 926
P++ + + L + EAF+RF I+ Y +L +
Sbjct: 302 SAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADS 361
Query: 927 TLQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961
R+ F K+ ++ F + +TQ+F FI+E
Sbjct: 362 LFDRQGFLKS-RDRAYAKFYTLLSKTQIFIRFIEE 395
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 77.0 bits (188), Expect = 8e-14
Identities = 107/434 (24%), Positives = 175/434 (40%), Gaps = 50/434 (11%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +YF+VV H+K + ++ Q+FP K F + I FC P
Sbjct: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQ-------GIELFCQPGG-- 53
Query: 622 WVPVQQFTSETFSFV-LTGEDGSRRFGYCRRL------LPGGKGKRL------------- 661
W ++ TF V LT D R + C L G K + +
Sbjct: 54 WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPA 113
Query: 662 ----PEVYCIVSRLGCFSLFSRILDEVEKRRGISPAL-VQPLMRSVMEAPFPALGKTILV 716
P+ +VSRL +F L + S + ++ L+ ++ PA G +
Sbjct: 114 EVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGS--Q 171
Query: 717 KNFLPGSGTEVIELCRPLDSRLE--HVDFESLFSSLSVRHLVCVFASLLLERRVIFIADK 774
K F G+G + + PL L LF L +++++ +F ++L E +V+F +
Sbjct: 172 KLFSLGAGDRQL-IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSAS 230
Query: 775 LSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLE 834
LS C A+ +L++P + + YIP+LP +++++ SPTPF+IG+ S + E L
Sbjct: 231 FQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHE--LL 288
Query: 835 EVLVVDLVNSRFLRQMDDEDSILPRKL----QVALEHILEQRNELACEQDEGPLDGRHGP 890
+V++ DL S LP L Q AL IL E+A P
Sbjct: 289 DVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTAL--S 346
Query: 891 ESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSL--RHFLEV 948
S L++ V F+R F ++ Y L + + + L FL
Sbjct: 347 HSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTK 406
Query: 949 FMETQMFRGFIQER 962
+ F GF+ ER
Sbjct: 407 VLSGMAFAGFVSER 420
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 70.9 bits (172), Expect = 6e-12
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 12/168 (7%)
Query: 704 EAPFPALGKTILVKNFLPGSGTEVIELC-RPLDSRLEHVDF--ESLFSSLSVRHLVCVFA 760
E P P G++ L SG +C RP + L DF + +F L V ++ +F
Sbjct: 250 EVPLPPPGRS------LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFT 303
Query: 761 SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGL 820
LLE +++ + L + AL++PF WQH Y+P+LP +++ + +P P+L+GL
Sbjct: 304 CALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGL 363
Query: 821 LSSSLP--LLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALE 866
S+ L ELP E L +++ F+ +D P KL+ E
Sbjct: 364 HSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQ-FPNKLEFVQE 410
Score = 31.6 bits (70), Expect = 3.9
Identities = 23/83 (27%), Positives = 35/83 (42%), Gaps = 9/83 (10%)
Query: 895 LNEVVSEAFVRFFVEIVGHYSLFLT--SGEREERTLQREAFRKAVSSKSLRH-------F 945
LN + E F F ++ Y +F+ S ++E RE + + L F
Sbjct: 512 LNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPF 571
Query: 946 LEVFMETQMFRGFIQERELRRQD 968
L F+ETQMF FI + + D
Sbjct: 572 LSRFLETQMFASFIDNKIMCHDD 594
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 70.5 bits (171), Expect = 8e-12
Identities = 58/225 (25%), Positives = 104/225 (46%), Gaps = 14/225 (6%)
Query: 746 LFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPA 805
LF L + +++ +F + L E +V+F++ L+ C ++AL++P + TY+P+LP
Sbjct: 214 LFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQ 273
Query: 806 MVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQ--- 862
+++++ +PTPF+IG+ ++ +E L +V+V DL LP LQ
Sbjct: 274 LLEVLSTPTPFIIGVNAAFQAETQE--LLDVIVADLDGGTVTIPECVHIPPLPEPLQSQT 331
Query: 863 -VALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSG 921
L +L+ ELA P + ++ + F+R F +++ Y L
Sbjct: 332 HSVLSMVLDPELELADLAFPPPTTSTSSLKMQ--DKELRAVFLRLFAQLLQGYRWCLHVV 389
Query: 922 EREERTLQREAFRKA--VSSKSL--RHFLEVFMETQMFRGFIQER 962
+ R F KA + + L FL +E F GF+ ER
Sbjct: 390 RIHPEPVIR--FHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSER 432
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 69.3 bits (168), Expect = 2e-11
Identities = 91/408 (22%), Positives = 157/408 (38%), Gaps = 50/408 (12%)
Query: 608 LKAIPQFCFPDAKDWVPVQQFTSETFSFVLTGEDGSRRFG----YCRRL-----LPGGKG 658
L +PQ CFP V + VLT G+R +G Y R L GK
Sbjct: 39 LLTLPQLCFPGGV-CVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKT 97
Query: 659 KR------LPEVYCIVSRL-------GCFSLFSRILDEVEKRRGISPALVQPLMRSVMEA 705
R +P C+VSR C S +L + S ++ +
Sbjct: 98 HRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSH--IKDFAAKLSLI 155
Query: 706 PFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFASLLLE 765
P P G LV N S V+ +S + +D ++ + +L E
Sbjct: 156 PSPPPGPLHLVFNMK--SLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTE 213
Query: 766 RRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGL-LSSS 824
+R++F + ++L+ +A +YP WQH ++P+L M+D V +PT FL+G L
Sbjct: 214 QRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHF 273
Query: 825 LPLLRELPLEEVLVVDLVNSRFLRQMDDE-----------DSILPRKLQVALEHILEQRN 873
+ +E ++ +D + + + DD + + R + L H L +
Sbjct: 274 EEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAH 333
Query: 874 EL-ACEQDEGPLDGRHGPE--SSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQR 930
L + + EG R + + + + + V F ++ H + E R
Sbjct: 334 LLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNY-------EHRVFNS 386
Query: 931 EAFRKAVSSKSLRHFLEVFMETQMFRGFIQERELRRQDAKGLFEVRAQ 978
E F K + + + +V ++T MF F++ R RR DA ++ Q
Sbjct: 387 EEFLKTRAPGDHQFYKQV-LDTYMFHSFLKARLNRRMDAFAQMDLDTQ 433
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 66.6 bits (161), Expect = 1e-10
Identities = 46/167 (27%), Positives = 79/167 (47%), Gaps = 10/167 (5%)
Query: 704 EAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVFAS 761
E P P G+++ E + RP S L D+ F L + +LV VF
Sbjct: 235 EVPLPPPGRSLKFYGVY-----EPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTC 289
Query: 762 LLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLL 821
+LLE +++ + L + L++PF WQH Y+P+LP +++ + +P P+L+GL
Sbjct: 290 VLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQ 349
Query: 822 S--SSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALE 866
S + ELP E L +++ F+ ++ +E P K+ E
Sbjct: 350 SKEGTDRSKLELPQEANLCFVDIDNHFI-ELPEEFPQFPNKVDFIQE 395
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 58.2 bits (139), Expect = 4e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
Query: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
Query: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
Score = 31.2 bits (69), Expect = 5.1
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
Query: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
+ ++ TS F F LT +D G R+G C
Sbjct: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,845,812
Number of Sequences: 37866
Number of extensions: 2406248
Number of successful extensions: 18136
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 287
Number of HSP's that attempted gapping in prelim test: 15411
Number of HSP's gapped (non-prelim): 2619
length of query: 1009
length of database: 18,247,518
effective HSP length: 112
effective length of query: 897
effective length of database: 14,006,526
effective search space: 12563853822
effective search space used: 12563853822
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.