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Search of human proteins with 154354981
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354981 regulating synaptic membrane exocytosis 2 isoform
b [Homo sapiens]
(1163 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354981 regulating synaptic membrane exocytosis 2 isoform b... 2343 0.0
gi|154354983 regulating synaptic membrane exocytosis 2 isoform a... 2191 0.0
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi... 938 0.0
gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapi... 346 8e-95
gi|33667061 regulating synaptic membrane exocytosis 4 [Homo sapi... 326 9e-89
gi|150170670 piccolo isoform 2 [Homo sapiens] 137 6e-32
gi|150378539 piccolo isoform 1 [Homo sapiens] 137 6e-32
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 74 6e-13
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 72 2e-12
gi|6005997 double C2-like domains, beta [Homo sapiens] 72 2e-12
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 71 5e-12
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 70 9e-12
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 70 9e-12
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 70 1e-11
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 70 1e-11
gi|238550198 synaptotagmin III [Homo sapiens] 69 2e-11
gi|238550196 synaptotagmin III [Homo sapiens] 69 2e-11
gi|14150054 synaptotagmin III [Homo sapiens] 69 2e-11
gi|47078261 double C2-like domains, alpha [Homo sapiens] 69 3e-11
gi|4506067 protein kinase C, alpha [Homo sapiens] 68 6e-11
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 67 8e-11
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 67 8e-11
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 67 8e-11
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens] 67 1e-10
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 66 2e-10
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 66 2e-10
gi|211059429 synaptotagmin II [Homo sapiens] 66 2e-10
gi|31543670 synaptotagmin II [Homo sapiens] 66 2e-10
gi|13384594 protein kinase C, gamma [Homo sapiens] 65 3e-10
gi|45504376 synaptotagmin VI [Homo sapiens] 65 3e-10
>gi|154354981 regulating synaptic membrane exocytosis 2 isoform b
[Homo sapiens]
Length = 1163
Score = 2343 bits (6071), Expect = 0.0
Identities = 1163/1163 (100%), Positives = 1163/1163 (100%)
Query: 1 MQFETLRQVCNSVLSHFHGVFSSPPNILQNELFGQTLNNARKRSPSVSRDQNRRYDQREE 60
MQFETLRQVCNSVLSHFHGVFSSPPNILQNELFGQTLNNARKRSPSVSRDQNRRYDQREE
Sbjct: 1 MQFETLRQVCNSVLSHFHGVFSSPPNILQNELFGQTLNNARKRSPSVSRDQNRRYDQREE 60
Query: 61 REEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDE 120
REEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDE
Sbjct: 61 REEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDE 120
Query: 121 DVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVS 180
DVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVS
Sbjct: 121 DVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVS 180
Query: 181 LANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHS 240
LANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHS
Sbjct: 181 LANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHS 240
Query: 241 PPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVR 300
PPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVR
Sbjct: 241 PPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVR 300
Query: 301 PPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHT 360
PPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHT
Sbjct: 301 PPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHT 360
Query: 361 SWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTE 420
SWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTE
Sbjct: 361 SWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTE 420
Query: 421 SGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVEL 480
SGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVEL
Sbjct: 421 SGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVEL 480
Query: 481 VVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLS 540
VVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLS
Sbjct: 481 VVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLS 540
Query: 541 IKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEP 600
IKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEP
Sbjct: 541 IKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEP 600
Query: 601 KWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKL 660
KWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKL
Sbjct: 601 KWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKL 660
Query: 661 QTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHD 720
QTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHD
Sbjct: 661 QTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHD 720
Query: 721 GRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRT 780
GRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRT
Sbjct: 721 GRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRT 780
Query: 781 MTGHYNTISRMDRHRVMDDHYSPDRDSHFLTLPRSRYSQTIDHHHRDGRDCEAADRQPYH 840
MTGHYNTISRMDRHRVMDDHYSPDRDSHFLTLPRSRYSQTIDHHHRDGRDCEAADRQPYH
Sbjct: 781 MTGHYNTISRMDRHRVMDDHYSPDRDSHFLTLPRSRYSQTIDHHHRDGRDCEAADRQPYH 840
Query: 841 RSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTS 900
RSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTS
Sbjct: 841 RSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTS 900
Query: 901 PSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRES 960
PSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRES
Sbjct: 901 PSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRES 960
Query: 961 TDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDK 1020
TDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDK
Sbjct: 961 TDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDK 1020
Query: 1021 KGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLS 1080
KGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLS
Sbjct: 1021 KGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLS 1080
Query: 1081 FEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTL 1140
FEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTL
Sbjct: 1081 FEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTL 1140
Query: 1141 APLTRRASQSSLESSTGPSYSRS 1163
APLTRRASQSSLESSTGPSYSRS
Sbjct: 1141 APLTRRASQSSLESSTGPSYSRS 1163
>gi|154354983 regulating synaptic membrane exocytosis 2 isoform a
[Homo sapiens]
Length = 1349
Score = 2191 bits (5676), Expect = 0.0
Identities = 1101/1139 (96%), Positives = 1101/1139 (96%), Gaps = 38/1139 (3%)
Query: 41 RKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLS 100
RKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLS
Sbjct: 233 RKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLS 292
Query: 101 YRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQ 160
YRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQ
Sbjct: 293 YRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQ 352
Query: 161 MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSM 220
MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSM
Sbjct: 353 MRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSM 412
Query: 221 ERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKRE 280
ERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKRE
Sbjct: 413 ERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHLDPSSAVRKTKRE 472
Query: 281 KMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVE 340
KMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVE
Sbjct: 473 KMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEELASTPEYTSCDDVE 532
Query: 341 IESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGS 400
IESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGS
Sbjct: 533 IESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRLIGRILLNKRLKDGS 592
Query: 401 VPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGA 460
VPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGA
Sbjct: 593 VPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVLEWNGRLLQGA 652
Query: 461 TFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVT 520
TFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVT
Sbjct: 653 TFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDRPSISVT 712
Query: 521 SPMSPGMLRDVPQFLSGQLS----------------IKLWFDKVGHQLIVTILGAKDLPS 564
SPMSPGMLRDVPQFLSGQLS IKLWFDKVGHQLIVTILGAKDLPS
Sbjct: 713 SPMSPGMLRDVPQFLSGQLSSQSLSRRTTPFVPRVQIKLWFDKVGHQLIVTILGAKDLPS 772
Query: 565 REDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT 624
REDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT
Sbjct: 773 REDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEIT 832
Query: 625 LWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHG 684
LWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHG
Sbjct: 833 LWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHG 892
Query: 685 ESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPS 744
ESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPS
Sbjct: 893 ESPTRRLQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPS 952
Query: 745 GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPD 804
GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPD
Sbjct: 953 GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPD 1012
Query: 805 RDSHFLTLPRSRYSQTIDHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERP 864
RD RDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERP
Sbjct: 1013 RD----------------------RDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERP 1050
Query: 865 DTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLD 924
DTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLD
Sbjct: 1051 DTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLD 1110
Query: 925 RKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASD 984
RKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASD
Sbjct: 1111 RKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASD 1170
Query: 985 SQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLP 1044
SQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLP
Sbjct: 1171 SQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLP 1230
Query: 1045 APYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHK 1104
APYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHK
Sbjct: 1231 APYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDHK 1290
Query: 1105 SFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1163
SFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS
Sbjct: 1291 SFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1349
>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapiens]
Length = 1692
Score = 938 bits (2424), Expect = 0.0
Identities = 514/923 (55%), Positives = 632/923 (68%), Gaps = 93/923 (10%)
Query: 94 EDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDE-----YERQRREEEYQSRYRSDPNLA 148
E+ + R+S R S++Y + E RDE E+QR+EE+YQ+RYRSDPNLA
Sbjct: 306 EERERKERRESRRLEKGRSQDY---PDTPEKRDEGKAADEEKQRKEEDYQTRYRSDPNLA 362
Query: 149 RYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISER 208
RYPVKP P E+QMR+HA VSRARHERRHSDV+L + + L + ++ + R
Sbjct: 363 RYPVKPPPEEQQMRMHARVSRARHERRHSDVALPRTEAG----AALPEGKAGKRAPAAAR 418
Query: 209 RAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLRRTDSLRKQHHL 268
+ ++ R+YS ERT E + P A++ TNHSPP PR P+P + P+L+ + LRKQ L
Sbjct: 419 ASPPDSPRAYSAERTAETRAPG--AKQLTNHSPPAPRHGPVPAEAPELKAQEPLRKQSRL 476
Query: 269 DPSSAV--RKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEEE 326
DPSSAV RK KREK+ETMLRNDSLSSDQSESVRP PPKPH+SK+GGK RQ+S+SSSEEE
Sbjct: 477 DPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPSPPKPHRSKRGGKKRQMSVSSSEEE 536
Query: 327 LASTPEYTSCDDVEIESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKDGDRL 386
STPEYTSC+DVE+ESESVSEKGD+DY WLD +WHS E SP+S HPVTWQPSK+GDRL
Sbjct: 537 GVSTPEYTSCEDVELESESVSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRL 596
Query: 387 IGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPG 446
IGR++LNKR ++P+DSGA+LGLKVVGGKMT+ GRL AFITKVKKGSLAD VGHLR G
Sbjct: 597 IGRVILNKRT---TMPKDSGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAG 653
Query: 447 DEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSS 506
DEVLEWNG+ L GAT EEVYNIILESK EPQVE++VSRPIGDIPRIP+S+H LESSSSS
Sbjct: 654 DEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSS 713
Query: 507 FESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSRE 566
FESQKM+RPSISV SP SPG L+D PQ L GQLS+KLW+DKVGHQLIV +L A DLP+R
Sbjct: 714 FESQKMERPSISVISPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPARV 773
Query: 567 DGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLW 626
DGRPRNPYVK+YFLPDRSDK+KRRTKTVKK LEPKWNQTF+YS VHRR+FRERMLEIT+W
Sbjct: 774 DGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVW 833
Query: 627 DQARVREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGES 686
DQ RV+EEESEFLGEILIELETALLDDEPHWYKLQTHD SSLPLP PSP+MPRR +HGES
Sbjct: 834 DQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGES 893
Query: 687 PTRRLQRSKRISDSEVSDYDCDDGIGVVS--DYRHDGRDLQSSTLSVPEQVMSSNHCSPS 744
+++LQRS+RISDS++SDY+ DDGIGVV YR R+ +S+TL+VPEQ +++H S S
Sbjct: 894 SSKKLQRSQRISDSDISDYEVDDGIGVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRS 953
Query: 745 GSPHRVDVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRV--MDDHYS 802
SPHR + G+ RS P+VP +S + R +R+ T H++ HR +D Y
Sbjct: 954 VSPHRGNDQGKPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYL 1013
Query: 803 PDRDSHFLTLPRSRYSQT----------IDHH-------------------------HRD 827
++DS L LPR++ ++ + H+ H
Sbjct: 1014 SEQDSELLMLPRAKRGRSAECLHTTRHLVRHYKTLPPKMPLLQSSSHWNIYSSILPAHTK 1073
Query: 828 GRDCEAADRQPYHRSRS------------TEQRPLLERTTTRSRSTERPDTNLMRSMPSL 875
+ D +H + +E +P L+R + S + RPDT+L P
Sbjct: 1074 TKSVTRQDISLHHECFNSTVLRFTDEILVSELQPFLDRARSASTNCLRPDTSL--HSPER 1131
Query: 876 MTGRSAPPSPALSRSHPRTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRST 935
GR SP+L R P + +Q +S P R R K RS+
Sbjct: 1132 ERGRW---SPSLDRRRPPSPRIQIQHAS-PENDRHSR-----------------KSERSS 1170
Query: 936 VQRSTETGLAVEMRNWMTRQASR 958
+Q+ T G A + + SR
Sbjct: 1171 IQKQTRKGTASDAERVLPTCLSR 1193
Score = 404 bits (1038), Expect = e-112
Identities = 250/494 (50%), Positives = 296/494 (59%), Gaps = 59/494 (11%)
Query: 718 RHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRVDVIGRT-RSWSPSVPPP-----QSRNV 771
+H R S S+ + S +H P GS ++ R R SP+ PP SR
Sbjct: 1210 KHPARSRSSEHSSI-RTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFSSRRG 1268
Query: 772 EQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDR------DSHFLTLPRSRYSQ------ 819
Q L +G S + R R L R +YS+
Sbjct: 1269 RQ-LPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNIHKD 1327
Query: 820 ---TIDHHHRDGRDCEAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLM 876
+ D+ D + +D R+ S + L T+ S +ERP + P +
Sbjct: 1328 QYRSCDNVSAKSSDSDVSDVSAISRTSSASR---LSSTSFMSEQSERPRGRISSFTPKMQ 1384
Query: 877 TGRSAPPSPALSRSHPRTGSVQT------SPSSTPVA---------------------GR 909
R ++ +S +G + T S S T V R
Sbjct: 1385 GRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSR 1444
Query: 910 RGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYS 969
R R QL ++G KKL+ST+QRSTETG+A EMR M RQ SRESTDGS+NSYS
Sbjct: 1445 RSRSTSQLS-----QTESGHKKLKSTIQRSTETGMAAEMRK-MVRQPSRESTDGSINSYS 1498
Query: 970 SEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEII 1029
SEGNLIFPGVRL +DSQFSDFLDGLGPAQLVGRQTLATPAMGDIQ+GM DKKGQLEVE+I
Sbjct: 1499 SEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVI 1558
Query: 1030 RARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKV 1089
RAR L KPGSK+ PAPYVKVYLL+NG CIAKKKT++ARKTL+PLYQQ L F+ESPQGKV
Sbjct: 1559 RARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKV 1618
Query: 1090 LQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQ 1149
LQ+IVWGDYGRMDHK FMGVAQILL+EL+LS+MVIGW+KLFPPSSLVDPTL PLTRRASQ
Sbjct: 1619 LQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQ 1678
Query: 1150 SSLESSTGPSYSRS 1163
SSLESSTGP RS
Sbjct: 1679 SSLESSTGPPCIRS 1692
Score = 73.2 bits (178), Expect = 1e-12
Identities = 46/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)
Query: 795 RVMDDHYSPDRDSHFLTLPRSRYSQTIDHHHRDGRDCEAA-------DRQPYHRSRSTEQ 847
R+ H SP+ D H RS +I R G +A R+ + R+T+Q
Sbjct: 1149 RIQIQHASPENDRHSRKSERS----SIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQ 1204
Query: 848 RPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHPRTGSVQTSPSSTPVA 907
+ + RSRS+E + SM L+ G SAPPSP L+R H + Q+ P+ T +
Sbjct: 1205 PVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADTSFS 1264
Query: 908 GRRGRQLPQLP 918
RRGRQLPQ+P
Sbjct: 1265 SRRGRQLPQVP 1275
Score = 48.9 bits (115), Expect = 3e-05
Identities = 128/553 (23%), Positives = 216/553 (39%), Gaps = 87/553 (15%)
Query: 178 DVSLANADLEDSRIS-MLRMDRPSRQRSISERRAAMENQR-SYSMERT----REAQGPSS 231
D SL + + E R S L RP R I + A+ EN R S ER+ + +G +S
Sbjct: 1123 DTSLHSPERERGRWSPSLDRRRPPSPR-IQIQHASPENDRHSRKSERSSIQKQTRKGTAS 1181
Query: 232 YAQRT-----TNHSPPTPRRSPLPIDR---PDLRRTD------SLRKQHHL------DPS 271
A+R + PR + P+ R P R+ +L HHL PS
Sbjct: 1182 DAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAPPS 1241
Query: 272 SAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISLSSSEE------ 325
+ + R++ T S +D S S R P + G + Q SL E
Sbjct: 1242 PLLTRMHRQRSPTQ----SPPADTSFSSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKM 1297
Query: 326 ---ELASTPEYTSCDDVEIESESVSEKGDMDYNWLDHTSWHSSEASPMSLHPVTWQPSKD 382
T S +++ E S Y D+ S SS++ + ++ S
Sbjct: 1298 KVHRFKQTTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSS-- 1355
Query: 383 GDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVK---------K 433
RL ++++ + PR + K+ G +M SGR T V
Sbjct: 1356 ASRLSSTSFMSEQSER---PRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHND 1412
Query: 434 GSLADT-VGHLRPGDE------------VLEWNGRLLQGATFEEVYNIILESKPEPQVEL 480
GS +DT VG + G + ++ R + E + L+S + E
Sbjct: 1413 GSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTET 1472
Query: 481 VVSRPIGDIPRIP--DSTHAQLESSSSS----FESQKM--DRPSISVTSPMSPGML---R 529
++ + + R P +ST + S SS F ++ D + P L +
Sbjct: 1473 GMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQ 1532
Query: 530 DVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKNK 588
+ G + I + DK G QL V ++ A+ L + + PYVK+Y L + + K
Sbjct: 1533 TLATPAMGDIQIGME-DKKG-QLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAK 1590
Query: 589 RRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLW-DQARVREEESEFLGEILIELE 647
++T+ +KTL+P + Q+ ++ + ++L++ +W D R+ + + +IL+E E
Sbjct: 1591 KKTRIARKTLDPLYQQSLVFD----ESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLE-E 1645
Query: 648 TALLDDEPHWYKL 660
L WYKL
Sbjct: 1646 LDLSSMVIGWYKL 1658
Score = 43.9 bits (102), Expect = 9e-04
Identities = 41/136 (30%), Positives = 67/136 (49%), Gaps = 10/136 (7%)
Query: 1019 DKKG-QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQ 1077
DK G QL V +++A L + + PYVK+Y L + +K++TK +K LEP + Q
Sbjct: 753 DKVGHQLIVNVLQATDLPARVDGRPRN-PYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQ 811
Query: 1078 LLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLD-ELELSNMVIGWFKL--F 1130
+ + ++L+I VW D R+ + + +IL++ E L + W+KL
Sbjct: 812 TFVYSHVHRRDFRERMLEITVW-DQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTH 870
Query: 1131 PPSSLVDPTLAPLTRR 1146
SSL P +P R
Sbjct: 871 DESSLPLPQPSPFMPR 886
>gi|48476344 regulating synaptic membrane exocytosis 3 [Homo sapiens]
Length = 308
Score = 346 bits (887), Expect = 8e-95
Identities = 173/249 (69%), Positives = 203/249 (81%), Gaps = 8/249 (3%)
Query: 913 QLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEG 972
QLPQ P+G KKLRS ++RSTETG+AVEMR+ +TRQ SRESTDGS NS SS+G
Sbjct: 68 QLPQ--PEGAT------KKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSDG 119
Query: 973 NLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRAR 1032
IFP RL ++SQFSDFLDGLGPAQ+VGRQTLATP MGD+ + +MD+ GQLEVE+I AR
Sbjct: 120 TFIFPTTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEAR 179
Query: 1033 GLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQI 1092
GL KPGSK+LPA Y+KVYLL+NG C+AKKKTK+ +KT +PLYQQ L F+E PQGKVLQ+
Sbjct: 180 GLTPKPGSKSLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFDEGPQGKVLQV 239
Query: 1093 IVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSL 1152
IVWGDYGRMDHK FMG+AQI+LDEL+LS V GW+KLFP SS+ D TL LTRR SQSSL
Sbjct: 240 IVWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKLFPTSSVADSTLGSLTRRLSQSSL 299
Query: 1153 ESSTGPSYS 1161
ES+T PS S
Sbjct: 300 ESATSPSCS 308
Score = 38.5 bits (88), Expect = 0.038
Identities = 27/104 (25%), Positives = 52/104 (50%), Gaps = 14/104 (13%)
Query: 558 GAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFR 617
G+K LP+ Y+K+Y L + + K++TK KKT +P + Q ++ +
Sbjct: 186 GSKSLPAT--------YIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFD----EGPQ 233
Query: 618 ERMLEITLW-DQARVREEESEFLGEILIELETALLDDEPHWYKL 660
++L++ +W D R+ + + +I+++ E L WYKL
Sbjct: 234 GKVLQVIVWGDYGRMDHKCFMGMAQIMLD-ELDLSAAVTGWYKL 276
>gi|33667061 regulating synaptic membrane exocytosis 4 [Homo sapiens]
Length = 269
Score = 326 bits (835), Expect = 9e-89
Identities = 159/241 (65%), Positives = 196/241 (81%), Gaps = 1/241 (0%)
Query: 924 DRKAG-GKKLRSTVQRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLA 982
D AG ++L+ +QRSTETGLAVEM + RQAS ES + SMNSY SEGNL + GV LA
Sbjct: 29 DEDAGDSRRLKGAIQRSTETGLAVEMPSRTLRQASHESIEDSMNSYGSEGNLNYGGVCLA 88
Query: 983 SDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKT 1042
SD+QFSDFL +GPAQ VGRQTLAT MGD+++G+ ++ GQLEV+II+ARGL KPGSKT
Sbjct: 89 SDAQFSDFLGSMGPAQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKT 148
Query: 1043 LPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMD 1102
LPA Y+K YLL+NG+CIAKKKTKVARK+L+PLY Q+L F ESPQGKVLQ+IVWG+YGRM+
Sbjct: 149 LPAAYIKAYLLENGICIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRME 208
Query: 1103 HKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSR 1162
K FMGVA++LL+EL+L+ + +GW+KLFP SS+VDP PL R+ASQ SLES+ GP R
Sbjct: 209 RKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGER 268
Query: 1163 S 1163
S
Sbjct: 269 S 269
Score = 42.0 bits (97), Expect = 0.003
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 15/132 (11%)
Query: 551 QLIVTILGAKDLPSREDGRPRNP-YVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY- 608
QL V I+ A+ L ++ + Y+K Y L + K++TK +K+L+P +NQ ++
Sbjct: 129 QLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARKSLDPLYNQVLLFP 188
Query: 609 -SPVHRREFRERMLEITLWDQARVREEESEFLG--EILIELETALLDDEPHWYKLQTHDV 665
SP + ++L++ +W R E +F+G +L+E E L WYKL
Sbjct: 189 ESP------QGKVLQVIVWGNYG-RMERKQFMGVARVLLE-ELDLTTLAVGWYKL--FPT 238
Query: 666 SSLPLPHPSPYM 677
SS+ P P +
Sbjct: 239 SSMVDPATGPLL 250
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 137 bits (345), Expect = 6e-32
Identities = 112/375 (29%), Positives = 174/375 (46%), Gaps = 85/375 (22%)
Query: 389 RILLNKRLKDGSVPRDSGAMLGLKVVGGKMT--ESGRLCAFITKVKKGSLADTVGHLRPG 446
RI + + KD +V SG LG+++VGGK SG + A+I K+ G A+ G L G
Sbjct: 4496 RIKITRDSKDHTV---SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEG 4552
Query: 447 DEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSS 506
+VLEWNG L T+EEV +II S+ + E+ V + + +S H +L +
Sbjct: 4553 MQVLEWNGIPLTSKTYEEVQSII--SQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKA 4610
Query: 507 FESQKM---------------------------------------DRPSISVTSPMSPGM 527
+ K S SV SP PG
Sbjct: 4611 VDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGS 4670
Query: 528 ----------------LRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPR 571
+ V ++G++ +++ +D +G+ LI+ IL A++L R++
Sbjct: 4671 PSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYD-LGN-LIIHILQARNLVPRDNNGYS 4728
Query: 572 NPYVKIYFLPDR---------SDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLE 622
+P+VK+Y LP R S + KRRTK V+K+L P+WNQT IY + + +++ LE
Sbjct: 4729 DPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLE 4788
Query: 623 ITLWDQARVREEESEFLGEILIEL-ETALLDDEPHWYKL--QTHDV-------SSLPLPH 672
+T+WD R ++FLGE+LI+L T+ LD+ P WY L QT + S
Sbjct: 4789 VTVWDYDRF--SSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQS 4846
Query: 673 PSPYMPRRQLHGESP 687
P P + + + HG P
Sbjct: 4847 PKPSVIKSRSHGIFP 4861
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 20/176 (11%)
Query: 1001 GRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL------- 1053
G + ++ P G+IQ+ + G L + I++AR LV + + P+VKVYLL
Sbjct: 4686 GTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNG-YSDPFVKVYLLPGRGQVM 4744
Query: 1054 --DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1107
N K++TK +K+L P + Q + ++ E + K L++ VW DY R F+
Sbjct: 4745 VVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVW-DYDRFSSNDFL 4803
Query: 1108 GVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1163
G I L + W+ L + +D + +SQSS + S PS +S
Sbjct: 4804 GEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKS----HSSQSS-QQSPKPSVIKS 4854
Score = 32.7 bits (73), Expect = 2.1
Identities = 41/204 (20%), Positives = 76/204 (37%), Gaps = 14/204 (6%)
Query: 49 RDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRS 108
+ +R + R +Y + T PRS D Q + + D ++S R ++S
Sbjct: 3408 KQPKKRSSGAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKS 3467
Query: 109 HRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVS 168
S + DDED + D R RR+ +Y A K +P + I +
Sbjct: 3468 VDTSVQ--TDDEDQDEWDMPTRSRRKARV-GKYGDSMTEAD---KTKPLSKVSSIAVQTV 3521
Query: 169 RARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQG 228
+++S+ + R +R ++ I A + + S+ EA
Sbjct: 3522 --------AEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADS 3573
Query: 229 PSSYAQRTTNHSPPTPRRSPLPID 252
+ Q + SPP ++ P P++
Sbjct: 3574 DTQSPQYLSATSPPKDKKRPTPLE 3597
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 137 bits (345), Expect = 6e-32
Identities = 112/375 (29%), Positives = 174/375 (46%), Gaps = 85/375 (22%)
Query: 389 RILLNKRLKDGSVPRDSGAMLGLKVVGGKMT--ESGRLCAFITKVKKGSLADTVGHLRPG 446
RI + + KD +V SG LG+++VGGK SG + A+I K+ G A+ G L G
Sbjct: 4496 RIKITRDSKDHTV---SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEG 4552
Query: 447 DEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSS 506
+VLEWNG L T+EEV +II S+ + E+ V + + +S H +L +
Sbjct: 4553 MQVLEWNGIPLTSKTYEEVQSII--SQQSGEAEICVRLDLNMLSDSENSQHLELHEPPKA 4610
Query: 507 FESQKM---------------------------------------DRPSISVTSPMSPGM 527
+ K S SV SP PG
Sbjct: 4611 VDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGS 4670
Query: 528 ----------------LRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPR 571
+ V ++G++ +++ +D +G+ LI+ IL A++L R++
Sbjct: 4671 PSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYD-LGN-LIIHILQARNLVPRDNNGYS 4728
Query: 572 NPYVKIYFLPDR---------SDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLE 622
+P+VK+Y LP R S + KRRTK V+K+L P+WNQT IY + + +++ LE
Sbjct: 4729 DPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLE 4788
Query: 623 ITLWDQARVREEESEFLGEILIEL-ETALLDDEPHWYKL--QTHDV-------SSLPLPH 672
+T+WD R ++FLGE+LI+L T+ LD+ P WY L QT + S
Sbjct: 4789 VTVWDYDRF--SSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQS 4846
Query: 673 PSPYMPRRQLHGESP 687
P P + + + HG P
Sbjct: 4847 PKPSVIKSRSHGIFP 4861
Score = 82.0 bits (201), Expect = 3e-15
Identities = 95/336 (28%), Positives = 146/336 (43%), Gaps = 54/336 (16%)
Query: 832 EAADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAP-PSPALSRS 890
E+ D H S+S++Q P +RS PD + +P++ S+P S + S
Sbjct: 4830 ESIDHGKSHSSQSSQQSPKPSVIKSRSHGIF-PDPSKDMQVPTIEKSHSSPGSSKSSSEG 4888
Query: 891 HPRTGSVQTSPSSTPV--------------AGRRGRQLPQLPPKGTLDRKAGGKKLRSTV 936
H R+ S S T V A +QL P K R A +
Sbjct: 4889 HLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRIQPTKPPNHRPAESSVSTGSS 4948
Query: 937 QRSTETGLAVEMRNWMTRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGP 996
S +G +V+ ++GS +S + E NL FP R+ Q +G P
Sbjct: 4949 GSSFGSGYSVD-------------SEGS-SSTAGETNL-FPIPRIGKMGQ-----NGQEP 4988
Query: 997 AQLVG------RQTLATPAMGDIQVGM---MDKKG-QLEVEIIRARGLVVKPGSKT-LPA 1045
+ G T MG+I++ + M G QL VEI++ R + K S LP
Sbjct: 4989 VKQPGVGVGLADTEAKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPD 5048
Query: 1046 PYVKVYLLDNGVC--IAKKKTKVARKTLEPLYQQLLSFEESPQGKVLQIIVWGDYGRMDH 1103
YVK+Y+++ + KKKT+V R EP + + F SP G LQI+++ + G+
Sbjct: 5049 LYVKIYVMNISTQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMK 5108
Query: 1104 KSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPT 1139
K+ +G A I LD+++L ++ W KL LV PT
Sbjct: 5109 KTLIGEACIWLDKVDLRKRIVNWHKL-----LVSPT 5139
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/176 (28%), Positives = 82/176 (46%), Gaps = 20/176 (11%)
Query: 1001 GRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL------- 1053
G + ++ P G+IQ+ + G L + I++AR LV + + P+VKVYLL
Sbjct: 4686 GTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNG-YSDPFVKVYLLPGRGQVM 4744
Query: 1054 --DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1107
N K++TK +K+L P + Q + ++ E + K L++ VW DY R F+
Sbjct: 4745 VVQNASAEYKRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVW-DYDRFSSNDFL 4803
Query: 1108 GVAQILLDELELSNMVIGWFKLFPPSSLVDPTLAPLTRRASQSSLESSTGPSYSRS 1163
G I L + W+ L + +D + +SQSS + S PS +S
Sbjct: 4804 GEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKS----HSSQSS-QQSPKPSVIKS 4854
Score = 35.8 bits (81), Expect = 0.24
Identities = 23/76 (30%), Positives = 40/76 (52%), Gaps = 4/76 (5%)
Query: 538 QLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNP--YVKIYFLPDRSDKN--KRRTKT 593
++++K G QLIV IL +++ + P YVKIY + + K K++T+
Sbjct: 5012 KIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNISTQKKVIKKKTRV 5071
Query: 594 VKKTLEPKWNQTFIYS 609
+ EP +N+TF +S
Sbjct: 5072 CRHDREPSFNETFRFS 5087
Score = 32.7 bits (73), Expect = 2.1
Identities = 41/204 (20%), Positives = 76/204 (37%), Gaps = 14/204 (6%)
Query: 49 RDQNRRYDQREEREEYSQYATSDTAMPRSPSDYADRRSQHEPQFYEDSDHLSYRDSNRRS 108
+ +R + R +Y + T PRS D Q + + D ++S R ++S
Sbjct: 3408 KQPKKRSSGAKVRGQYDDMGENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKS 3467
Query: 109 HRHSKEYIVDDEDVESRDEYERQRREEEYQSRYRSDPNLARYPVKPQPYEEQMRIHAEVS 168
S + DDED + D R RR+ +Y A K +P + I +
Sbjct: 3468 VDTSVQ--TDDEDQDEWDMPTRSRRKARV-GKYGDSMTEAD---KTKPLSKVSSIAVQTV 3521
Query: 169 RARHERRHSDVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRSYSMERTREAQG 228
+++S+ + R +R ++ I A + + S+ EA
Sbjct: 3522 --------AEISVQTEPVGTIRTPSIRARVDAKVEIIKHISAPEKTYKGGSLGCQTEADS 3573
Query: 229 PSSYAQRTTNHSPPTPRRSPLPID 252
+ Q + SPP ++ P P++
Sbjct: 3574 DTQSPQYLSATSPPKDKKRPTPLE 3597
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 74.3 bits (181), Expect = 6e-13
Identities = 57/194 (29%), Positives = 98/194 (50%), Gaps = 17/194 (8%)
Query: 477 QVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQKMDR--PSISVTSPMSPGMLRDVPQF 534
Q+ ++VS+ G + +H+ SSSS E ++ P I+ ++P L V
Sbjct: 909 QLGILVSQHSG----VEAHSHSYSHSSSSLSEEPELSGGPPHITSSAPELRQRLTHVDSP 964
Query: 535 LS------GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGR-PRNPYVKIYFLPDRSDKN 587
L GQ+ + LW+ +L+ + G + L R++GR P +PYV + LPD++
Sbjct: 965 LEAPAGPLGQVKLTLWYYSEERKLVSIVHGCRSL--RQNGRDPPDPYVSLLLLPDKNRGT 1022
Query: 588 KRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL- 646
KRRT K+TL P++N+ F + + E + R L++++ + E E LG++ ++L
Sbjct: 1023 KRRTSQKKRTLSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLA 1081
Query: 647 ETALLDDEPHWYKL 660
ET L WY L
Sbjct: 1082 ETDLSQGVARWYDL 1095
Score = 36.6 bits (83), Expect = 0.14
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 1044 PAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGR 1100
P PYV + LL + K++T ++TL P + + +E + Q + L + V +
Sbjct: 1006 PDPYVSLLLLPDKNRGTKRRTSQKKRTLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSF 1065
Query: 1101 MD-HKSFMGVAQILLDELELSNMVIGWFKL 1129
M + +G Q+ L E +LS V W+ L
Sbjct: 1066 MSRERELLGKVQLDLAETDLSQGVARWYDL 1095
Score = 33.9 bits (76), Expect = 0.93
Identities = 58/256 (22%), Positives = 105/256 (41%), Gaps = 57/256 (22%)
Query: 550 HQLIVTILGAKDLPSRE-------DGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKW 602
H L + +L A+DL +++ G+ +PYVK+ L RS R+ V++ L P+W
Sbjct: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKS-DPYVKLK-LAGRSF----RSHVVREDLNPRW 700
Query: 603 NQTF--IYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETAL----LDDEPH 656
N+ F I + V +E LE+ ++D+ ++ +FLG + L T L LD+
Sbjct: 701 NEVFEVIVTSVPGQE-----LEVEVFDKDL---DKDDFLGRCKVRLTTVLNSGFLDE--- 749
Query: 657 WYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSDYDCDDGIGVVSD 716
W L+ +P ++ +L L+ +++ + + ++S
Sbjct: 750 WLTLE-------DVPSGRLHLRLERLTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSI 802
Query: 717 YRHDGRDLQSSTLSVPEQVMSSNHCSP------SGSPHRVDVIGRTRS--WSPS----VP 764
Y DL + H SP S H+ I +T + W S +
Sbjct: 803 YMERAEDLPLR--------KGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIR 854
Query: 765 PPQSRNVEQGLRGTRT 780
P + ++E +RG T
Sbjct: 855 KPHTESLELQVRGEGT 870
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 72.4 bits (176), Expect = 2e-12
Identities = 48/164 (29%), Positives = 78/164 (47%), Gaps = 6/164 (3%)
Query: 498 AQLESSSSSFESQKMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTIL 557
A+ + + F D + + G P + G ++KL L + ++
Sbjct: 1522 AECDLVCTFFHPLLRDEKAEGIARSADAGSFSPTPGQIGG--AVKLSISYRNGTLFIMVM 1579
Query: 558 GAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFR 617
KDL + EDG NPYVK Y LPD +KR+TK +KT P +N+ +YS + R
Sbjct: 1580 HIKDLVT-EDGADPNPYVKTYLLPDNHKTSKRKTKISRKTRNPTFNEMLVYSGYSKETLR 1638
Query: 618 ERMLEITLWDQARVREEESEFLGEILIELETALLDDEP-HWYKL 660
+R L++++ +R E+ FLG + + L+ L E WY+L
Sbjct: 1639 QRELQLSVLSAESLR--ENFFLGGVTLPLKDFNLSKETVKWYQL 1680
Score = 56.6 bits (135), Expect = 1e-07
Identities = 34/123 (27%), Positives = 66/123 (53%), Gaps = 7/123 (5%)
Query: 1011 GDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKT 1070
G +++ + + G L + ++ + LV + G+ P PYVK YLL + +K+KTK++RKT
Sbjct: 1561 GAVKLSISYRNGTLFIMVMHIKDLVTEDGAD--PNPYVKTYLLPDNHKTSKRKTKISRKT 1618
Query: 1071 LEPLYQQLLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGW 1126
P + ++L + +E+ + + LQ+ V + F+G + L + LS + W
Sbjct: 1619 RNPTFNEMLVYSGYSKETLRQRELQLSVLSAES-LRENFFLGGVTLPLKDFNLSKETVKW 1677
Query: 1127 FKL 1129
++L
Sbjct: 1678 YQL 1680
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 72.4 bits (176), Expect = 2e-12
Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 2/111 (1%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G L L +D+ + L TI AK L + +PYVK++ LP S NK RTKT++
Sbjct: 128 GTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRN 187
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELE 647
TL P WN+T Y + + + L I++ D+ + R +EF+GE + L+
Sbjct: 188 TLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFR--HNEFIGETRVPLK 236
Score = 60.8 bits (146), Expect = 7e-09
Identities = 36/122 (29%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++ I L + L+V I+ L + + +PYVK Y PD K+K +T KK
Sbjct: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKK 327
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH 656
TL P++N+ F Y H + ++ LE+T+WD + ++F+G +++ + A + H
Sbjct: 328 TLNPEFNEEFCYEIKH-GDLAKKSLEVTVWDYD--IGKSNDFIGGVVLGIH-AKGERLKH 383
Query: 657 WY 658
W+
Sbjct: 384 WF 385
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/117 (29%), Positives = 57/117 (48%), Gaps = 10/117 (8%)
Query: 1009 AMGDIQVGMM--DKKGQLEVEIIRARGLVVKPGSKT-LPAPYVKVYLLDNGVCIAKKKTK 1065
A+G + ++ + L I +A+GL KP L PYVK++LL K +TK
Sbjct: 126 ALGTLDFSLLYDQENNALHCTITKAKGL--KPMDHNGLADPYVKLHLLPGASKANKLRTK 183
Query: 1066 VARKTLEPLYQQLLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELE 1118
R TL P + + L++ +E K L+I V D + H F+G ++ L +L+
Sbjct: 184 TLRNTLNPTWNETLTYYGITDEDMIRKTLRISVC-DEDKFRHNEFIGETRVPLKKLK 239
Score = 33.5 bits (75), Expect = 1.2
Identities = 23/66 (34%), Positives = 32/66 (48%), Gaps = 4/66 (6%)
Query: 1046 PYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMD 1102
PYVK YL + +K KT V +KTL P + + +E K L++ VW DY
Sbjct: 304 PYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVW-DYDIGK 362
Query: 1103 HKSFMG 1108
F+G
Sbjct: 363 SNDFIG 368
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 71.2 bits (173), Expect = 5e-12
Identities = 49/145 (33%), Positives = 78/145 (53%), Gaps = 11/145 (7%)
Query: 993 GLGPAQLVGRQTLATPAM---GDIQVGMMDKKGQLEVEIIRARGL-VVKPGSKTLPAPYV 1048
G PA T A P G++++ + K +L + ++ RGL +++ G+ P PYV
Sbjct: 1485 GTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGND--PDPYV 1542
Query: 1049 KVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQG----KVLQIIVWGDYGRMDHK 1104
K+YLL + K+KTKVARKT P Y ++L ++ P+G + LQ+ V + G ++
Sbjct: 1543 KIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWEN- 1601
Query: 1105 SFMGVAQILLDELELSNMVIGWFKL 1129
+G I L EL+L+ GWF L
Sbjct: 1602 VLLGEVNIRLRELDLAQEKTGWFAL 1626
Score = 68.9 bits (167), Expect = 3e-11
Identities = 37/129 (28%), Positives = 68/129 (52%), Gaps = 3/129 (2%)
Query: 541 IKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEP 600
+KL ++L + ++ + L +DG +PYVKIY LPD KR+TK +KT P
Sbjct: 1508 VKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNP 1567
Query: 601 KWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL-ETALLDDEPHWYK 659
+N+ +Y + + + ++R L++++ + E+ LGE+ I L E L ++ W+
Sbjct: 1568 TYNEMLVYDGIPKGDLQQRELQLSVLSEQGF--WENVLLGEVNIRLRELDLAQEKTGWFA 1625
Query: 660 LQTHDVSSL 668
L + +L
Sbjct: 1626 LGSRSHGTL 1634
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 70.5 bits (171), Expect = 9e-12
Identities = 37/111 (33%), Positives = 59/111 (53%), Gaps = 2/111 (1%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G L L +D+ L TI+ AK L + +PYVK++ LP S NK RTKT++
Sbjct: 394 GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRN 453
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELE 647
T P WN+T +Y + + + + L I++ D+ + +EF+GE L+
Sbjct: 454 TRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF--GHNEFIGETRFSLK 502
Score = 55.5 bits (132), Expect = 3e-07
Identities = 33/123 (26%), Positives = 65/123 (52%), Gaps = 4/123 (3%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++ + L + LIV I+ L + + +P+VK++ PD K K +T+ KK
Sbjct: 552 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 611
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH 656
TL P++N+ F Y H + ++ L+I++WD + ++++G + + +A + H
Sbjct: 612 TLNPEFNEEFFYDIKH-SDLAKKSLDISVWDYD--IGKSNDYIGGCQLGI-SAKGERLKH 667
Query: 657 WYK 659
WY+
Sbjct: 668 WYE 670
Score = 46.2 bits (108), Expect = 2e-04
Identities = 35/100 (35%), Positives = 52/100 (52%), Gaps = 8/100 (8%)
Query: 1024 LEVEIIRARGLVVKP-GSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF- 1081
L+ II+A+GL KP S L PYVK++LL K +TK R T P++ + L +
Sbjct: 409 LQCTIIKAKGL--KPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYH 466
Query: 1082 ---EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELE 1118
+E Q K L+I V D + H F+G + L +L+
Sbjct: 467 GITDEDMQRKTLRISVC-DEDKFGHNEFIGETRFSLKKLK 505
Score = 33.1 bits (74), Expect = 1.6
Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 7/107 (6%)
Query: 1011 GDIQVGMM--DKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1068
G I V +M ++G L V IIR L + P+VK++L + AK KT++ +
Sbjct: 552 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANG-YSDPFVKLWLKPDMGKKAKHKTQIKK 610
Query: 1069 KTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMDHKSFMGVAQI 1112
KTL P + + ++ K L I VW DY ++G Q+
Sbjct: 611 KTLNPEFNEEFFYDIKHSDLAKKSLDISVW-DYDIGKSNDYIGGCQL 656
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 70.5 bits (171), Expect = 9e-12
Identities = 37/111 (33%), Positives = 59/111 (53%), Gaps = 2/111 (1%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G L L +D+ L TI+ AK L + +PYVK++ LP S NK RTKT++
Sbjct: 390 GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRN 449
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELE 647
T P WN+T +Y + + + + L I++ D+ + +EF+GE L+
Sbjct: 450 TRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKF--GHNEFIGETRFSLK 498
Score = 55.5 bits (132), Expect = 3e-07
Identities = 33/123 (26%), Positives = 65/123 (52%), Gaps = 4/123 (3%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++ + L + LIV I+ L + + +P+VK++ PD K K +T+ KK
Sbjct: 548 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 607
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH 656
TL P++N+ F Y H + ++ L+I++WD + ++++G + + +A + H
Sbjct: 608 TLNPEFNEEFFYDIKH-SDLAKKSLDISVWDYD--IGKSNDYIGGCQLGI-SAKGERLKH 663
Query: 657 WYK 659
WY+
Sbjct: 664 WYE 666
Score = 46.2 bits (108), Expect = 2e-04
Identities = 35/100 (35%), Positives = 52/100 (52%), Gaps = 8/100 (8%)
Query: 1024 LEVEIIRARGLVVKP-GSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF- 1081
L+ II+A+GL KP S L PYVK++LL K +TK R T P++ + L +
Sbjct: 405 LQCTIIKAKGL--KPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYH 462
Query: 1082 ---EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELE 1118
+E Q K L+I V D + H F+G + L +L+
Sbjct: 463 GITDEDMQRKTLRISVC-DEDKFGHNEFIGETRFSLKKLK 501
Score = 33.1 bits (74), Expect = 1.6
Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 7/107 (6%)
Query: 1011 GDIQVGMM--DKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVAR 1068
G I V +M ++G L V IIR L + P+VK++L + AK KT++ +
Sbjct: 548 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANG-YSDPFVKLWLKPDMGKKAKHKTQIKK 606
Query: 1069 KTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMDHKSFMGVAQI 1112
KTL P + + ++ K L I VW DY ++G Q+
Sbjct: 607 KTLNPEFNEEFFYDIKHSDLAKKSLDISVW-DYDIGKSNDYIGGCQL 652
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/106 (34%), Positives = 63/106 (59%), Gaps = 2/106 (1%)
Query: 549 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 608
G +L V I AK+L + + G + +VK Y LP R+ +KR+T +KKTL P +N TF+Y
Sbjct: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
Query: 609 SPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDE 654
+ V + + LE+T+WD+ + ++FLG + + + T + + E
Sbjct: 585 NGVRLEDLQHMCLELTVWDREPL--ASNDFLGGVRLGVGTGISNGE 628
Score = 64.3 bits (155), Expect = 6e-10
Identities = 43/153 (28%), Positives = 78/153 (50%), Gaps = 13/153 (8%)
Query: 510 QKMDRPSISVTSPMSP-GMLRDVPQ--------FLSGQLSIKLWFDKVGHQLIVTILGAK 560
QK+ R S+ S MS G + + F++G+++ L +++ L+V +
Sbjct: 322 QKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECH 381
Query: 561 DLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRER 619
L ++ + R NPYVK Y LPD+S + KR+T + T+ P +++T Y + +R
Sbjct: 382 QLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IPESLLAQR 440
Query: 620 MLEITLWDQARVREEESEFLGEILIELETALLD 652
L+ ++W R + FLGE I++++ LD
Sbjct: 441 TLQFSVWHHGRF--GRNTFLGEAEIQMDSWKLD 471
Score = 55.1 bits (131), Expect = 4e-07
Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 1024 LEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEE 1083
L V + L +K PYVK YLL + K+KT + R T+ PLY + L + E
Sbjct: 373 LVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY-E 431
Query: 1084 SPQG----KVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPT 1139
P+ + LQ VW +GR +F+G A+I +D +L + L S PT
Sbjct: 432 IPESLLAQRTLQFSVW-HHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
Query: 1140 LAP 1142
P
Sbjct: 491 GLP 493
Score = 41.6 bits (96), Expect = 0.004
Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 1007 TPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKV 1066
TP GD + + G+L+V I A+ L T + +VK YLL +K+KT V
Sbjct: 511 TPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDS-FVKGYLLPMRNKASKRKTPV 569
Query: 1067 ARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNM 1122
+KTL P Y + E Q L++ VW D + F+G ++ + +
Sbjct: 570 MKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVW-DREPLASNDFLGGVRLGVGTGISNGE 628
Query: 1123 VIGW 1126
V+ W
Sbjct: 629 VVDW 632
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 70.1 bits (170), Expect = 1e-11
Identities = 37/106 (34%), Positives = 63/106 (59%), Gaps = 2/106 (1%)
Query: 549 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 608
G +L V I AK+L + + G + +VK Y LP R+ +KR+T +KKTL P +N TF+Y
Sbjct: 525 GGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVY 584
Query: 609 SPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDE 654
+ V + + LE+T+WD+ + ++FLG + + + T + + E
Sbjct: 585 NGVRLEDLQHMCLELTVWDREPL--ASNDFLGGVRLGVGTGISNGE 628
Score = 64.3 bits (155), Expect = 6e-10
Identities = 43/153 (28%), Positives = 78/153 (50%), Gaps = 13/153 (8%)
Query: 510 QKMDRPSISVTSPMSP-GMLRDVPQ--------FLSGQLSIKLWFDKVGHQLIVTILGAK 560
QK+ R S+ S MS G + + F++G+++ L +++ L+V +
Sbjct: 322 QKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECH 381
Query: 561 DLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRER 619
L ++ + R NPYVK Y LPD+S + KR+T + T+ P +++T Y + +R
Sbjct: 382 QLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IPESLLAQR 440
Query: 620 MLEITLWDQARVREEESEFLGEILIELETALLD 652
L+ ++W R + FLGE I++++ LD
Sbjct: 441 TLQFSVWHHGRF--GRNTFLGEAEIQMDSWKLD 471
Score = 55.1 bits (131), Expect = 4e-07
Identities = 39/123 (31%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 1024 LEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEE 1083
L V + L +K PYVK YLL + K+KT + R T+ PLY + L + E
Sbjct: 373 LVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRY-E 431
Query: 1084 SPQG----KVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVDPT 1139
P+ + LQ VW +GR +F+G A+I +D +L + L S PT
Sbjct: 432 IPESLLAQRTLQFSVW-HHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 490
Query: 1140 LAP 1142
P
Sbjct: 491 GLP 493
Score = 41.6 bits (96), Expect = 0.004
Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 1007 TPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKV 1066
TP GD + + G+L+V I A+ L T + +VK YLL +K+KT V
Sbjct: 511 TPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDS-FVKGYLLPMRNKASKRKTPV 569
Query: 1067 ARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNM 1122
+KTL P Y + E Q L++ VW D + F+G ++ + +
Sbjct: 570 MKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVW-DREPLASNDFLGGVRLGVGTGISNGE 628
Query: 1123 VIGW 1126
V+ W
Sbjct: 629 VVDW 632
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 69.3 bits (168), Expect = 2e-11
Identities = 45/124 (36%), Positives = 70/124 (56%), Gaps = 8/124 (6%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++S L + QL+V IL A DLP+++ +PYVKIY LPDR K K +TK +K
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRK 358
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLD---D 653
TL P +N+TF +S V E +R L +++D R + +G+++++ L + D
Sbjct: 359 TLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLDNLLELAEQPPD 415
Query: 654 EPHW 657
P W
Sbjct: 416 RPLW 419
Score = 48.5 bits (114), Expect = 4e-05
Identities = 88/310 (28%), Positives = 115/310 (37%), Gaps = 63/310 (20%)
Query: 838 PYHRSRSTEQRP---LLERTTTRSRSTERPDTNLMRSMPSLMTGR-SAPPSPALSRSHPR 893
P+H + + P LLE + T P M S P +A P+
Sbjct: 130 PHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPS------- 182
Query: 894 TGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMR---- 949
QTSP P G G L LPP G GG L S T LA R
Sbjct: 183 ----QTSPE-LPSEGGAGSGLLLLPPSG------GG--LPSAQSHQQVTSLAPTTRYPAL 229
Query: 950 -NWMTRQASRESTDGSMNSYSSEGNLIFPG----VRLASDSQFSDFLDGLGPAQLVGRQT 1004
+T+Q D S L PG +L + + G GP GR++
Sbjct: 230 PRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIK-PELYQGTGPG---GRRS 285
Query: 1005 LATPAMGDIQVGM-----------MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1053
P G+ G + QL V I++A L K S PYVK+YLL
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKD-SNGFSDPYVKIYLL 344
Query: 1054 DNGVCIAKKK--TKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1107
+ KKK TKV RKTL P++ + F E Q K L V+ D+ R +
Sbjct: 345 PD----RKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRK-LHFSVY-DFDRFSRHDLI 398
Query: 1108 GVAQILLDEL 1117
G Q++LD L
Sbjct: 399 G--QVVLDNL 406
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 1022 GQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1081
G+L V II+A L + PYVK L+ G + K+KT + + TL P Y + L F
Sbjct: 446 GRLTVTIIKASNLKAMDLTG-FSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1082 EESPQG--KVLQIIVWGDYGRMDHKSFMGVAQI 1112
+ +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 40.0 bits (92), Expect = 0.013
Identities = 21/72 (29%), Positives = 37/72 (51%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G+L+ L + +L VTI+ A +L + + +PYVK + + KR+T K
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKN 492
Query: 597 TLEPKWNQTFIY 608
TL P +N+ ++
Sbjct: 493 TLNPTYNEALVF 504
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 69.3 bits (168), Expect = 2e-11
Identities = 45/124 (36%), Positives = 70/124 (56%), Gaps = 8/124 (6%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++S L + QL+V IL A DLP+++ +PYVKIY LPDR K K +TK +K
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRK 358
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLD---D 653
TL P +N+TF +S V E +R L +++D R + +G+++++ L + D
Sbjct: 359 TLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLDNLLELAEQPPD 415
Query: 654 EPHW 657
P W
Sbjct: 416 RPLW 419
Score = 48.5 bits (114), Expect = 4e-05
Identities = 88/310 (28%), Positives = 115/310 (37%), Gaps = 63/310 (20%)
Query: 838 PYHRSRSTEQRP---LLERTTTRSRSTERPDTNLMRSMPSLMTGR-SAPPSPALSRSHPR 893
P+H + + P LLE + T P M S P +A P+
Sbjct: 130 PHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPS------- 182
Query: 894 TGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMR---- 949
QTSP P G G L LPP G GG L S T LA R
Sbjct: 183 ----QTSPE-LPSEGGAGSGLLLLPPSG------GG--LPSAQSHQQVTSLAPTTRYPAL 229
Query: 950 -NWMTRQASRESTDGSMNSYSSEGNLIFPG----VRLASDSQFSDFLDGLGPAQLVGRQT 1004
+T+Q D S L PG +L + + G GP GR++
Sbjct: 230 PRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIK-PELYQGTGPG---GRRS 285
Query: 1005 LATPAMGDIQVGM-----------MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1053
P G+ G + QL V I++A L K S PYVK+YLL
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKD-SNGFSDPYVKIYLL 344
Query: 1054 DNGVCIAKKK--TKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1107
+ KKK TKV RKTL P++ + F E Q K L V+ D+ R +
Sbjct: 345 PD----RKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRK-LHFSVY-DFDRFSRHDLI 398
Query: 1108 GVAQILLDEL 1117
G Q++LD L
Sbjct: 399 G--QVVLDNL 406
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 1022 GQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1081
G+L V II+A L + PYVK L+ G + K+KT + + TL P Y + L F
Sbjct: 446 GRLTVTIIKASNLKAMDLTG-FSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1082 EESPQG--KVLQIIVWGDYGRMDHKSFMGVAQI 1112
+ +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 40.0 bits (92), Expect = 0.013
Identities = 21/72 (29%), Positives = 37/72 (51%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G+L+ L + +L VTI+ A +L + + +PYVK + + KR+T K
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKN 492
Query: 597 TLEPKWNQTFIY 608
TL P +N+ ++
Sbjct: 493 TLNPTYNEALVF 504
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 69.3 bits (168), Expect = 2e-11
Identities = 45/124 (36%), Positives = 70/124 (56%), Gaps = 8/124 (6%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++S L + QL+V IL A DLP+++ +PYVKIY LPDR K K +TK +K
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDR--KKKFQTKVHRK 358
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLD---D 653
TL P +N+TF +S V E +R L +++D R + +G+++++ L + D
Sbjct: 359 TLNPVFNETFQFS-VPLAELAQRKLHFSVYDFDRF--SRHDLIGQVVLDNLLELAEQPPD 415
Query: 654 EPHW 657
P W
Sbjct: 416 RPLW 419
Score = 48.5 bits (114), Expect = 4e-05
Identities = 88/310 (28%), Positives = 115/310 (37%), Gaps = 63/310 (20%)
Query: 838 PYHRSRSTEQRP---LLERTTTRSRSTERPDTNLMRSMPSLMTGR-SAPPSPALSRSHPR 893
P+H + + P LLE + T P M S P +A P+
Sbjct: 130 PHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPS------- 182
Query: 894 TGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMR---- 949
QTSP P G G L LPP G GG L S T LA R
Sbjct: 183 ----QTSPE-LPSEGGAGSGLLLLPPSG------GG--LPSAQSHQQVTSLAPTTRYPAL 229
Query: 950 -NWMTRQASRESTDGSMNSYSSEGNLIFPG----VRLASDSQFSDFLDGLGPAQLVGRQT 1004
+T+Q D S L PG +L + + G GP GR++
Sbjct: 230 PRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIK-PELYQGTGPG---GRRS 285
Query: 1005 LATPAMGDIQVGM-----------MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1053
P G+ G + QL V I++A L K S PYVK+YLL
Sbjct: 286 GGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKD-SNGFSDPYVKIYLL 344
Query: 1054 DNGVCIAKKK--TKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVWGDYGRMDHKSFM 1107
+ KKK TKV RKTL P++ + F E Q K L V+ D+ R +
Sbjct: 345 PD----RKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRK-LHFSVY-DFDRFSRHDLI 398
Query: 1108 GVAQILLDEL 1117
G Q++LD L
Sbjct: 399 G--QVVLDNL 406
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/93 (32%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 1022 GQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1081
G+L V II+A L + PYVK L+ G + K+KT + + TL P Y + L F
Sbjct: 446 GRLTVTIIKASNLKAMDLTG-FSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVF 504
Query: 1082 EESPQG--KVLQIIVWGDYGRMDHKSFMGVAQI 1112
+ +P+ V I DY + H +GV ++
Sbjct: 505 DVAPESVENVGLSIAVVDYDCIGHNEVIGVCRV 537
Score = 40.0 bits (92), Expect = 0.013
Identities = 21/72 (29%), Positives = 37/72 (51%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G+L+ L + +L VTI+ A +L + + +PYVK + + KR+T K
Sbjct: 433 GELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKN 492
Query: 597 TLEPKWNQTFIY 608
TL P +N+ ++
Sbjct: 493 TLNPTYNEALVF 504
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 68.6 bits (166), Expect = 3e-11
Identities = 43/138 (31%), Positives = 66/138 (47%), Gaps = 5/138 (3%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G L L +D+ L +IL AK L + +PYVK++ LP NK +TKT +
Sbjct: 91 GTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRN 150
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH 656
TL P WN+ YS + + ++L I + D+ ++ +EF+GEI + L + H
Sbjct: 151 TLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKL--SHNEFIGEIRVPLRRLKPSQKKH 208
Query: 657 WYKLQTHDVSSLPLPHPS 674
+ V PL PS
Sbjct: 209 FNICLERQV---PLASPS 223
Score = 55.8 bits (133), Expect = 2e-07
Identities = 30/91 (32%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++ + L + L+V IL L + + +PYVK Y PD K+K +T KK
Sbjct: 253 GRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKK 312
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWD 627
TL P++N+ F Y + + LE+T+WD
Sbjct: 313 TLNPEFNEEFFYE-IELSTLATKTLEVTVWD 342
Score = 48.1 bits (113), Expect = 5e-05
Identities = 41/120 (34%), Positives = 65/120 (54%), Gaps = 12/120 (10%)
Query: 1009 AMGDIQVGMMDKKGQ--LEVEIIRARGLVVKPGS-KTLPAPYVKVYLLDNGVCIAKK-KT 1064
A+G ++ ++ + L I+RA+GL KP L PYVK++LL G C A K KT
Sbjct: 89 ALGTLEFDLLYDRASCTLHCSILRAKGL--KPMDFNGLADPYVKLHLLP-GACKANKLKT 145
Query: 1065 KVARKTLEPLYQQLLSF----EESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELS 1120
K R TL P++ + L++ ++ KVL+I V D ++ H F+G ++ L L+ S
Sbjct: 146 KTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVC-DEDKLSHNEFIGEIRVPLRRLKPS 204
Score = 34.3 bits (77), Expect = 0.71
Identities = 23/66 (34%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 1046 PYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMD 1102
PYVK YL + +K KT V +KTL P + + +E + K L++ VW DY
Sbjct: 289 PYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVW-DYDIGK 347
Query: 1103 HKSFMG 1108
F+G
Sbjct: 348 SNDFIG 353
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 67.8 bits (164), Expect = 6e-11
Identities = 35/124 (28%), Positives = 69/124 (55%), Gaps = 7/124 (5%)
Query: 551 QLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSP 610
+L VT+ AK+L + +PYVK+ +PD +++K++TKT++ TL P+WN++F +
Sbjct: 172 KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFK- 230
Query: 611 VHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKL---QTHDVSS 667
+ ++R L + +WD R ++F+G + + + WYKL + + +
Sbjct: 231 -LKPSDKDRRLSVEIWDWDRT--TRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYN 287
Query: 668 LPLP 671
+P+P
Sbjct: 288 VPIP 291
Score = 47.4 bits (111), Expect = 8e-05
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 7/110 (6%)
Query: 1023 QLEVEIIRARGLV-VKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1081
+L V + A+ L+ + P L PYVK+ L+ + +K+KTK R TL P + + +F
Sbjct: 172 KLHVTVRDAKNLIPMDPNG--LSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTF 229
Query: 1082 EESPQGK--VLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKL 1129
+ P K L + +W D+ R FMG + EL + GW+KL
Sbjct: 230 KLKPSDKDRRLSVEIW-DWDRTTRNDFMGSLSFGVSEL-MKMPASGWYKL 277
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 67.4 bits (163), Expect = 8e-11
Identities = 31/80 (38%), Positives = 50/80 (62%)
Query: 549 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 608
G L V I AK+L + + G + +VK Y LPD S K +T +KK++ P+WN TF++
Sbjct: 586 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 645
Query: 609 SPVHRREFRERMLEITLWDQ 628
S +H ++ + LE+T+WD+
Sbjct: 646 SGIHPQDIKNVCLELTIWDK 665
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/129 (27%), Positives = 69/129 (53%), Gaps = 6/129 (4%)
Query: 535 LSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKT 593
+SG++ + + + L + + ++L ++ + R + YVK Y LPD+S NKR+TK
Sbjct: 406 VSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK- 464
Query: 594 VKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDD 653
++ P++N+T Y+ H + R L++++W R + FLGE+ I ++ ++
Sbjct: 465 IRTGTNPEFNETLKYTISH-TQLETRTLQLSVWHYDRF--GRNSFLGEVEIPFDSWNFEN 521
Query: 654 -EPHWYKLQ 661
W+ LQ
Sbjct: 522 PTDEWFVLQ 530
Score = 48.1 bits (113), Expect = 5e-05
Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 5/115 (4%)
Query: 1020 KKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLL 1079
K G L + + R L + K YVK YLL + K+KTK+ R P + + L
Sbjct: 419 KTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI-RTGTNPEFNETL 477
Query: 1080 SFEESP---QGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFP 1131
+ S + + LQ+ VW Y R SF+G +I D N WF L P
Sbjct: 478 KYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQP 531
Score = 32.0 bits (71), Expect = 3.5
Identities = 29/106 (27%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 994 LGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1053
L P QL G +T G + + G LEV I A+ L T + +VK YLL
Sbjct: 562 LPPEQLQGNKTFKK---GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDS-FVKGYLL 617
Query: 1054 DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVW 1095
+ K KT V +K++ P + F + + L++ +W
Sbjct: 618 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW 663
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 67.4 bits (163), Expect = 8e-11
Identities = 31/80 (38%), Positives = 50/80 (62%)
Query: 549 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 608
G L V I AK+L + + G + +VK Y LPD S K +T +KK++ P+WN TF++
Sbjct: 608 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 667
Query: 609 SPVHRREFRERMLEITLWDQ 628
S +H ++ + LE+T+WD+
Sbjct: 668 SGIHPQDIKNVCLELTIWDK 687
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/129 (27%), Positives = 69/129 (53%), Gaps = 6/129 (4%)
Query: 535 LSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKT 593
+SG++ + + + L + + ++L ++ + R + YVK Y LPD+S NKR+TK
Sbjct: 428 VSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK- 486
Query: 594 VKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDD 653
++ P++N+T Y+ H + R L++++W R + FLGE+ I ++ ++
Sbjct: 487 IRTGTNPEFNETLKYTISH-TQLETRTLQLSVWHYDRF--GRNSFLGEVEIPFDSWNFEN 543
Query: 654 -EPHWYKLQ 661
W+ LQ
Sbjct: 544 PTDEWFVLQ 552
Score = 48.1 bits (113), Expect = 5e-05
Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 5/115 (4%)
Query: 1020 KKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLL 1079
K G L + + R L + K YVK YLL + K+KTK+ R P + + L
Sbjct: 441 KTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI-RTGTNPEFNETL 499
Query: 1080 SFEESP---QGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFP 1131
+ S + + LQ+ VW Y R SF+G +I D N WF L P
Sbjct: 500 KYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQP 553
Score = 32.0 bits (71), Expect = 3.5
Identities = 29/106 (27%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 994 LGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1053
L P QL G +T G + + G LEV I A+ L T + +VK YLL
Sbjct: 584 LPPEQLQGNKTFKK---GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDS-FVKGYLL 639
Query: 1054 DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVW 1095
+ K KT V +K++ P + F + + L++ +W
Sbjct: 640 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW 685
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 67.4 bits (163), Expect = 8e-11
Identities = 31/80 (38%), Positives = 50/80 (62%)
Query: 549 GHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIY 608
G L V I AK+L + + G + +VK Y LPD S K +T +KK++ P+WN TF++
Sbjct: 586 GGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMF 645
Query: 609 SPVHRREFRERMLEITLWDQ 628
S +H ++ + LE+T+WD+
Sbjct: 646 SGIHPQDIKNVCLELTIWDK 665
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/129 (27%), Positives = 69/129 (53%), Gaps = 6/129 (4%)
Query: 535 LSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPR-NPYVKIYFLPDRSDKNKRRTKT 593
+SG++ + + + L + + ++L ++ + R + YVK Y LPD+S NKR+TK
Sbjct: 406 VSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK- 464
Query: 594 VKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDD 653
++ P++N+T Y+ H + R L++++W R + FLGE+ I ++ ++
Sbjct: 465 IRTGTNPEFNETLKYTISH-TQLETRTLQLSVWHYDRF--GRNSFLGEVEIPFDSWNFEN 521
Query: 654 -EPHWYKLQ 661
W+ LQ
Sbjct: 522 PTDEWFVLQ 530
Score = 48.1 bits (113), Expect = 5e-05
Identities = 36/115 (31%), Positives = 50/115 (43%), Gaps = 5/115 (4%)
Query: 1020 KKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLL 1079
K G L + + R L + K YVK YLL + K+KTK+ R P + + L
Sbjct: 419 KTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKI-RTGTNPEFNETL 477
Query: 1080 SFEESP---QGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFP 1131
+ S + + LQ+ VW Y R SF+G +I D N WF L P
Sbjct: 478 KYTISHTQLETRTLQLSVW-HYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQP 531
Score = 32.0 bits (71), Expect = 3.5
Identities = 29/106 (27%), Positives = 45/106 (42%), Gaps = 8/106 (7%)
Query: 994 LGPAQLVGRQTLATPAMGDIQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLL 1053
L P QL G +T G + + G LEV I A+ L T + +VK YLL
Sbjct: 562 LPPEQLQGNKTFKK---GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDS-FVKGYLL 617
Query: 1054 DNGVCIAKKKTKVARKTLEPLYQQLLSFE----ESPQGKVLQIIVW 1095
+ K KT V +K++ P + F + + L++ +W
Sbjct: 618 PDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIW 663
>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
Length = 910
Score = 66.6 bits (161), Expect = 1e-10
Identities = 54/186 (29%), Positives = 93/186 (50%), Gaps = 18/186 (9%)
Query: 486 IGDIPRIPDSTHA---QLESSSSSFESQKMDRPSISVTSPMSP--GMLRDVPQFLSGQLS 540
I +P PD+ + +L+ S S + D S SV S S G L + G +
Sbjct: 555 ISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLE-----VKGNIQ 609
Query: 541 IKLWFDKVGHQLIVTILGAKDLPSREDGRPRN-PYVKIYFLPDRSDKNKRRTKTVKKTLE 599
+ + + +L V + KDL + + + R+ PYVK Y LPD+ K++T VKKTL
Sbjct: 610 FAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLN 669
Query: 600 PKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPH--- 656
P +N+ Y + ++ + + L +++W R + + FLGE+ ++LET D++ +
Sbjct: 670 PVYNEILRYK-IEKQILKTQKLNLSIWH--RDTFKRNSFLGEVELDLETWDWDNKQNKQL 726
Query: 657 -WYKLQ 661
WY L+
Sbjct: 727 RWYPLK 732
Score = 53.5 bits (127), Expect = 1e-06
Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 4/88 (4%)
Query: 561 DLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERM 620
DLP G N +VK LPD S K++++T+ V KT P +N T +Y + E
Sbjct: 779 DLPLLR-GSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEAC 837
Query: 621 LEITLWDQARVREEESEFLGEILIELET 648
+E+T+WD ++ ++FLG + I T
Sbjct: 838 VELTVWDHYKL---TNQFLGGLRIGFGT 862
Score = 52.0 bits (123), Expect = 3e-06
Identities = 75/302 (24%), Positives = 120/302 (39%), Gaps = 38/302 (12%)
Query: 852 ERTTTRSRSTER-PDTNLMRSMPSLMTGRSA--PPSPALSRSHPRTGSVQTSPSSTPVAG 908
E T R +S E P N + S +T + P SPA SH V+ PS P
Sbjct: 425 EVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSH----CVEPEPSQVPGGS 480
Query: 909 RRGRQLPQ----LPPKGTLDRKAGGKKLRSTVQR-STETGLAVEMRNWMTRQASRESTDG 963
R RQ P TL+R A K +++ S+++ ++ N + R + D
Sbjct: 481 SRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDN-QPEELVRSAEDD 539
Query: 964 SMNSYSSEGNLIFPGVRLAS---DSQFS--DFLDGLG---PAQLVGRQTLATPAMGDIQV 1015
N P + D+ FS D L + PA L + + ++
Sbjct: 540 EKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDF 599
Query: 1016 GMMDKKG-------------QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKK 1062
G ++ KG +L V + + + L K PYVK YLL + + KK
Sbjct: 600 GNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKK 659
Query: 1063 KTKVARKTLEPLYQQLLSFEESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELEL 1119
KT V +KTL P+Y ++L ++ Q + L + +W SF+G ++ L+ +
Sbjct: 660 KTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIW-HRDTFKRNSFLGEVELDLETWDW 718
Query: 1120 SN 1121
N
Sbjct: 719 DN 720
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 65.9 bits (159), Expect = 2e-10
Identities = 46/174 (26%), Positives = 90/174 (51%), Gaps = 21/174 (12%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++ I+ D+ LIV + AK+L + +PYVK+ +PD ++K++TKT+K
Sbjct: 160 GRIYIQAHIDR--DVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEI---LIELETALLDD 653
+L P+WN+TF + + ++R L + +WD ++F+G + + EL+ A +D
Sbjct: 218 SLNPEWNETFRFQ--LKESDKDRRLSVEIWDWDLT--SRNDFMGSLSFGISELQKASVDG 273
Query: 654 EPHWYKLQTHDVS---SLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSD 704
W+KL + + ++P+P P E ++ +R+K ++V +
Sbjct: 274 ---WFKLLSQEEGEYFNVPVP------PEGSEANEELRQKFERAKISQGTKVPE 318
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/106 (29%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 1026 VEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE--E 1083
+ ++R +V L PYVK+ L+ + +K+KTK + +L P + + F+ E
Sbjct: 174 IVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKE 233
Query: 1084 SPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKL 1129
S + + L + +W D+ FMG + EL+ ++ V GWFKL
Sbjct: 234 SDKDRRLSVEIW-DWDLTSRNDFMGSLSFGISELQKAS-VDGWFKL 277
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 65.9 bits (159), Expect = 2e-10
Identities = 46/174 (26%), Positives = 90/174 (51%), Gaps = 21/174 (12%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++ I+ D+ LIV + AK+L + +PYVK+ +PD ++K++TKT+K
Sbjct: 160 GRIYIQAHIDR--DVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKC 217
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEI---LIELETALLDD 653
+L P+WN+TF + + ++R L + +WD ++F+G + + EL+ A +D
Sbjct: 218 SLNPEWNETFRFQ--LKESDKDRRLSVEIWDWDLT--SRNDFMGSLSFGISELQKASVDG 273
Query: 654 EPHWYKLQTHDVS---SLPLPHPSPYMPRRQLHGESPTRRLQRSKRISDSEVSD 704
W+KL + + ++P+P P E ++ +R+K ++V +
Sbjct: 274 ---WFKLLSQEEGEYFNVPVP------PEGSEANEELRQKFERAKISQGTKVPE 318
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/106 (29%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 1026 VEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE--E 1083
+ ++R +V L PYVK+ L+ + +K+KTK + +L P + + F+ E
Sbjct: 174 IVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKE 233
Query: 1084 SPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKL 1129
S + + L + +W D+ FMG + EL+ ++ V GWFKL
Sbjct: 234 SDKDRRLSVEIW-DWDLTSRNDFMGSLSFGISELQKAS-VDGWFKL 277
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/126 (33%), Positives = 68/126 (53%), Gaps = 6/126 (4%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G+L L +D +QL V +L A +LP+ + G +PYVK++ LPD+ K K TK +K
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK--KKKYETKVHRK 198
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDE-P 655
TL P +N+TF + V +E + L + ++D R + + +GE+ + + T L
Sbjct: 199 TLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRF--SKHDIIGEVKVPMNTVDLGQPIE 255
Query: 656 HWYKLQ 661
W LQ
Sbjct: 256 EWRDLQ 261
Score = 50.4 bits (119), Expect = 1e-05
Identities = 37/104 (35%), Positives = 55/104 (52%), Gaps = 7/104 (6%)
Query: 1010 MGDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVA 1067
+GDI + + G+L V I+ A+ L K L PYVK++L+ NG + KKKT V
Sbjct: 271 LGDICTSLRYVPTAGKLTVCILEAKNLK-KMDVGGLSDPYVKIHLMQNGKRLKKKKTTVK 329
Query: 1068 RKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMDHKSFMG 1108
+KTL P + + SFE E Q KV ++ DY ++ +G
Sbjct: 330 KKTLNPYFNESFSFEIPFEQIQ-KVQVVVTVLDYDKLGKNEAIG 372
Score = 48.1 bits (113), Expect = 5e-05
Identities = 29/108 (26%), Positives = 58/108 (53%), Gaps = 3/108 (2%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G + L + +L V IL AK+L + G +PYVKI+ + + K++T KK
Sbjct: 272 GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKK 331
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILI 644
TL P +N++F + + + ++ + +T+ D ++ + E+ +G+I +
Sbjct: 332 TLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGKNEA--IGKIFV 376
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 1023 QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE 1082
QL V +++A L T PYVKV+LL + K +TKV RKTL P + + +F+
Sbjct: 155 QLTVGVLQAAELPALDMGGTSD-PYVKVFLLPDKK--KKYETKVHRKTLNPAFNETFTFK 211
Query: 1083 ESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGW 1126
Q GK L + ++ D+ R +G ++ ++ ++L + W
Sbjct: 212 VPYQELGGKTLVMAIY-DFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/126 (33%), Positives = 68/126 (53%), Gaps = 6/126 (4%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G+L L +D +QL V +L A +LP+ + G +PYVK++ LPD+ K K TK +K
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK--KKKYETKVHRK 198
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDE-P 655
TL P +N+TF + V +E + L + ++D R + + +GE+ + + T L
Sbjct: 199 TLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRF--SKHDIIGEVKVPMNTVDLGQPIE 255
Query: 656 HWYKLQ 661
W LQ
Sbjct: 256 EWRDLQ 261
Score = 50.4 bits (119), Expect = 1e-05
Identities = 37/104 (35%), Positives = 55/104 (52%), Gaps = 7/104 (6%)
Query: 1010 MGDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVA 1067
+GDI + + G+L V I+ A+ L K L PYVK++L+ NG + KKKT V
Sbjct: 271 LGDICTSLRYVPTAGKLTVCILEAKNLK-KMDVGGLSDPYVKIHLMQNGKRLKKKKTTVK 329
Query: 1068 RKTLEPLYQQLLSFE---ESPQGKVLQIIVWGDYGRMDHKSFMG 1108
+KTL P + + SFE E Q KV ++ DY ++ +G
Sbjct: 330 KKTLNPYFNESFSFEIPFEQIQ-KVQVVVTVLDYDKLGKNEAIG 372
Score = 48.1 bits (113), Expect = 5e-05
Identities = 29/108 (26%), Positives = 58/108 (53%), Gaps = 3/108 (2%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G + L + +L V IL AK+L + G +PYVKI+ + + K++T KK
Sbjct: 272 GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKK 331
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILI 644
TL P +N++F + + + ++ + +T+ D ++ + E+ +G+I +
Sbjct: 332 TLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGKNEA--IGKIFV 376
Score = 42.4 bits (98), Expect = 0.003
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 1023 QLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFE 1082
QL V +++A L T PYVKV+LL + K +TKV RKTL P + + +F+
Sbjct: 155 QLTVGVLQAAELPALDMGGTSD-PYVKVFLLPDKK--KKYETKVHRKTLNPAFNETFTFK 211
Query: 1083 ESPQ---GKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGW 1126
Q GK L + ++ D+ R +G ++ ++ ++L + W
Sbjct: 212 VPYQELGGKTLVMAIY-DFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 65.5 bits (158), Expect = 3e-10
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 43/178 (24%)
Query: 551 QLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSP 610
++ VT+ A++L + +PYVK+ +PD + K++T+TVK TL P WN+TF+++
Sbjct: 172 EIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFN- 230
Query: 611 VHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTHD------ 664
+ ER L + +WD R ++F+G + + L WYKL +
Sbjct: 231 -LKPGDVERRLSVEVWDWDRT--SRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYN 287
Query: 665 ---------------------------------VSSLPLPHPSPYMPRRQLHGESPTR 689
S +P P PSP P+R G SP R
Sbjct: 288 VPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGR 345
Score = 48.9 bits (115), Expect = 3e-05
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 7/110 (6%)
Query: 1023 QLEVEIIRARGLV-VKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1081
++ V + AR L+ + P L PYVK+ L+ + + K+KT+ + TL P++ + F
Sbjct: 172 EIHVTVGEARNLIPMDPNG--LSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVF 229
Query: 1082 EESPQG--KVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKL 1129
P + L + VW D+ R FMG + EL L V GW+KL
Sbjct: 230 NLKPGDVERRLSVEVW-DWDRTSRNDFMGAMSFGVSEL-LKAPVDGWYKL 277
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 65.5 bits (158), Expect = 3e-10
Identities = 39/109 (35%), Positives = 65/109 (59%), Gaps = 5/109 (4%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G+++ L +D LIV IL A DLP+++ +PYVKIY LPDR K K +T+ +K
Sbjct: 146 GKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDR--KCKLQTRVHRK 203
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIE 645
TL P +++ F + PV E +R L ++++D R + +GE++++
Sbjct: 204 TLNPTFDENF-HFPVPYEELADRKLHLSVFDFDRF--SRHDMIGEVILD 249
Score = 52.0 bits (123), Expect = 3e-06
Identities = 33/107 (30%), Positives = 57/107 (53%), Gaps = 5/107 (4%)
Query: 1010 MGDIQVGM--MDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVA 1067
+G+I + + G+L + +I+ R L + PYVKV LL +G + KKKT +
Sbjct: 277 LGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITG-YSDPYVKVSLLCDGRRLKKKKTTIK 335
Query: 1068 RKTLEPLYQQLLSFEESPQG--KVLQIIVWGDYGRMDHKSFMGVAQI 1112
+ TL P+Y + + F+ P+ +V +I DY R+ H +GV ++
Sbjct: 336 KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRV 382
Score = 40.0 bits (92), Expect = 0.013
Identities = 25/99 (25%), Positives = 47/99 (47%), Gaps = 1/99 (1%)
Query: 537 GQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKK 596
G++ L + +L +T++ ++L + + +PYVK+ L D K++T K
Sbjct: 278 GEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKN 337
Query: 597 TLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEE 635
TL P +N+ I+ + + L I++ D RV E
Sbjct: 338 TLNPVYNEAIIFD-IPPENMDQVSLLISVMDYDRVGHNE 375
Score = 38.5 bits (88), Expect = 0.038
Identities = 34/99 (34%), Positives = 50/99 (50%), Gaps = 13/99 (13%)
Query: 1024 LEVEIIRARGLVVKP--GSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSF 1081
L V I++A L K GS PYVK+YLL + C K +T+V RKTL P + + F
Sbjct: 161 LIVRILKAFDLPAKDFCGSSD---PYVKIYLLPDRKC--KLQTRVHRKTLNPTFDENFHF 215
Query: 1082 E---ESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDEL 1117
E + L + V+ D+ R +G +++LD L
Sbjct: 216 PVPYEELADRKLHLSVF-DFDRFSRHDMIG--EVILDNL 251
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,331,336
Number of Sequences: 37866
Number of extensions: 2419592
Number of successful extensions: 12214
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 457
Number of HSP's that attempted gapping in prelim test: 10074
Number of HSP's gapped (non-prelim): 2200
length of query: 1163
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1050
effective length of database: 13,968,660
effective search space: 14667093000
effective search space used: 14667093000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.