Search of human proteins with 154350244

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo
sapiens]
         (971 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]  1875   0.0  
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]  1852   0.0  
gi|210032790 hypothetical protein LOC27146 [Homo sapiens]             265   2e-70
gi|71061468 centromere protein E [Homo sapiens]                       160   4e-39
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       156   1e-37
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       156   1e-37
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        156   1e-37
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        156   1e-37
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        156   1e-37
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        156   1e-37
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        156   1e-37
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        156   1e-37
gi|38044112 restin isoform b [Homo sapiens]                           154   4e-37
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    150   6e-36
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   145   2e-34
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    145   2e-34
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            145   2e-34
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                 144   4e-34
gi|4506751 restin isoform a [Homo sapiens]                            142   2e-33
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   141   3e-33
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   140   6e-33
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   139   1e-32
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   139   1e-32
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   139   1e-32
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   139   1e-32
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   136   8e-32
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   136   8e-32
gi|21735548 centrosomal protein 2 [Homo sapiens]                      136   1e-31
gi|58530840 desmoplakin isoform I [Homo sapiens]                      134   4e-31
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      133   7e-31

>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 1875 bits (4856), Expect = 0.0
 Identities = 971/971 (100%), Positives = 971/971 (100%)

Query: 1   MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
           MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE
Sbjct: 1   MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60

Query: 61  KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
           KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE
Sbjct: 61  KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120

Query: 121 RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180
           RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK
Sbjct: 121 RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180

Query: 181 TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 240
           TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE
Sbjct: 181 TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 240

Query: 241 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 300
           VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE
Sbjct: 241 VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 300

Query: 301 RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 360
           RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS
Sbjct: 301 RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 360

Query: 361 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 420
           KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV
Sbjct: 361 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 420

Query: 421 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 480
           LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA
Sbjct: 421 LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 480

Query: 481 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 540
           LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH
Sbjct: 481 LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 540

Query: 541 EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 600
           EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA
Sbjct: 541 EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 600

Query: 601 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 660
           QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE
Sbjct: 601 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 660

Query: 661 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 720
           LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH
Sbjct: 661 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 720

Query: 721 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
           HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL
Sbjct: 721 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780

Query: 781 TKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKK 840
           TKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKK
Sbjct: 781 TKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKK 840

Query: 841 LIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALE 900
           LIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALE
Sbjct: 841 LIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALE 900

Query: 901 SGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQ 960
           SGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQ
Sbjct: 901 SGGVGNGHPNRLDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQ 960

Query: 961 RQEWFARYFTF 971
           RQEWFARYFTF
Sbjct: 961 RQEWFARYFTF 971


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 1852 bits (4796), Expect = 0.0
 Identities = 971/1020 (95%), Positives = 971/1020 (95%), Gaps = 49/1020 (4%)

Query: 1    MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
            MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE
Sbjct: 121  MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 180

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE
Sbjct: 181  KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 240

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180
            RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK
Sbjct: 241  RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 300

Query: 181  TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 240
            TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE
Sbjct: 301  TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 360

Query: 241  VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 300
            VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE
Sbjct: 361  VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 420

Query: 301  RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 360
            RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS
Sbjct: 421  RAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 480

Query: 361  KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 420
            KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV
Sbjct: 481  KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV 540

Query: 421  LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 480
            LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA
Sbjct: 541  LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 600

Query: 481  LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 540
            LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH
Sbjct: 601  LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 660

Query: 541  EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 600
            EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA
Sbjct: 661  EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 720

Query: 601  QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 660
            QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE
Sbjct: 721  QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 780

Query: 661  LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 720
            LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH
Sbjct: 781  LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 840

Query: 721  HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
            HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL
Sbjct: 841  HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 900

Query: 781  TKELEFKGKEILRIRSESNQQIR------------------------------------- 803
            TKELEFKGKEILRIRSESNQQIR                                     
Sbjct: 901  TKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNE 960

Query: 804  ------------LEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE 851
                        LEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE
Sbjct: 961  LLKEINAALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLE 1020

Query: 852  LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR 911
            LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR
Sbjct: 1021 LVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNR 1080

Query: 912  LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF 971
            LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF
Sbjct: 1081 LDPIPNSPVHDIEFNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFTF 1140



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 132/620 (21%), Positives = 270/620 (43%), Gaps = 116/620 (18%)

Query: 280 IKDLESEKSRVNERLSQLEEERAFLRSK-TQSLDEEQKQQILE--LEK--KVNEAKRTQQ 334
           +KD   E+  + + L++  E+    +SK T+ LD  +K Q+LE  LE   K+ +   T+ 
Sbjct: 72  LKDAHEEE--IQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEF 129

Query: 335 EYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWK------------------HHMAIE- 375
           E Y+  ++++Q   E +  Q     S+ +EE+  K                    +A+E 
Sbjct: 130 EAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALED 189

Query: 376 --AVHSNAIRDKKKLQMD-----------LEEQHNKDKLNLEEDKNQLQQELENLKEVLE 422
             A H   I++  K Q D            EE H  +  +L +   +L+ E + L E  E
Sbjct: 190 LQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYE 249

Query: 423 DKLNTANQEIGHLQDMVRKSEQGLGSAEGLIA---------------------------- 454
            KLN A        D +++S+  L +AE L A                            
Sbjct: 250 GKLNKAQSFYERELDTLKRSQ--LFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKT 307

Query: 455 ----------SLQDSQERLQNELDLTKDSLKETKDALLNV-EGE--LEQERQQHEETIAA 501
                     SL D  ++LQ  L + +++++  +  L +  EGE  L  + ++ E  +AA
Sbjct: 308 ELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAA 367

Query: 502 MKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA 561
            +E    ++ + A DL +K +     + +++ +E+ ++  E +KS +++ L   + E+  
Sbjct: 368 ARE----RLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAF 423

Query: 562 ARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQ 621
            R   Q   E+   QI  L++ +       +T  +  + +    + RL +E+ +L E H 
Sbjct: 424 LRSKTQSLDEEQKQQILELEKKVN---EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 480

Query: 622 QRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQ 681
           +  + L   H +A + +     ++++ L+  L+++H+ +        + ++E  + +++Q
Sbjct: 481 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKD--------KLNLEEDKNQLQQ 532

Query: 682 ELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHH---------QELAAAKMELE 732
           EL+ L+  LED+    L +   E+ H      D++R +             L  ++  L+
Sbjct: 533 ELENLKEVLEDK----LNTANQEIGHLQ----DMVRKSEQGLGSAEGLIASLQDSQERLQ 584

Query: 733 RSIDISRRQSKEHICRITDLQEEL-RHREHHISELDKEVQHLHENISALTKELEFKGKEI 791
             +D+++   KE    + +++ EL + R+ H   +    +     +  +  +LE K  E 
Sbjct: 585 NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTEN 644

Query: 792 LRIR-SESNQQIRLEEMEEK 810
           LR   S+  +++RL+  E+K
Sbjct: 645 LRQECSKLREELRLQHEEDK 664



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 41/215 (19%), Positives = 92/215 (42%), Gaps = 17/215 (7%)

Query: 651 NHLQQKHSAELQSLKDAHRESMEGFRIEMEQEL------QTLRFELEDEGKAMLASLRSE 704
           N    +H + +Q+LKDAH E ++    E  +++       T   +L  + + + +SL   
Sbjct: 59  NTKNDEHESAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDH 118

Query: 705 LNHQHAAAIDLLRHNHHQE---LAAAKMELERSIDIS------RRQSKEHICRITDLQEE 755
           +  +  A  +   + H  E   L A    ++R + +S      RR+ +E +     LQ +
Sbjct: 119 IKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQ 178

Query: 756 LRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRE 815
              ++  ++  D +  H  E I  L K  +     + + + ++ +  R+E      ++ E
Sbjct: 179 F-EKDKRLALEDLQAAHRRE-IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEE 236

Query: 816 SKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQL 850
            + E  ++I + +  L +     ++ ++  K  QL
Sbjct: 237 LRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQL 271


>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
          Length = 1060

 Score =  265 bits (676), Expect = 2e-70
 Identities = 251/1045 (24%), Positives = 465/1045 (44%), Gaps = 172/1045 (16%)

Query: 1    MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
            + ++AL E  + +   ++ +L  EA+H +R++T+SRE+ E++  +E +L+          
Sbjct: 114  LTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHL-------- 165

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
                        +H    Q  L  +   +        K+E     E++ +   ++ LR+E
Sbjct: 166  -----------TSHEATPQGRLPQESPET--------KSEPGQGPEMQEVLLEVQRLRVE 206

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLKRS-QLFTAESLQASKEKEADLRKEFQGQEAILR 179
             ++L +DY  K  + Q+ YERE + ++++ Q   +++L   +EKE+DLRK FQ QE+ L+
Sbjct: 207  NQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQ 266

Query: 180  KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 239
              + KL+ +L+    +   L    QKL+         +Q L  QL +A++    L    K
Sbjct: 267  AQVRKLEGDLEHRGRKISDLKKYAQKLK-------ERIQDLDVQLKEARQENSELKGTAK 319

Query: 240  EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 299
            ++  +LA A++R+  Q              + TQ T  +   +L SE   + E  + LE 
Sbjct: 320  KLGEKLAVAKDRMMLQEC------------RGTQQTDAMKT-ELVSENKVLREE-NDLEA 365

Query: 300  ERAFLRSKTQSLDE---EQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLN 356
                 +     L E    +    ++ +K+ +      ++ YE +L+ ++ + EEE   L 
Sbjct: 366  GNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLK 425

Query: 357  EAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELEN 416
            +   K LE+L  KH + I++V S+   ++KKLQ ++E Q  + +   E++  QL++E   
Sbjct: 426  DQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEE--- 482

Query: 417  LKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKE 476
             K  L  KL  +  E+  L++ +++++     AE               EL     S+ E
Sbjct: 483  -KAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAE-----------ESPQELGRQHCSILE 530

Query: 477  TKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL 536
            T+D  L ++ E     +++++ +AA   EE    D+                  + R ++
Sbjct: 531  TQDPCLKLD-ETSPRGEEYQDKLAA---EEGTSSDE------------------EERTKV 568

Query: 537  RLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQ 596
             L+   D +  +  LL+ K  +     + WQ +   L  Q+S ++Q LE   S  +  LQ
Sbjct: 569  LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQ 628

Query: 597  QLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK 656
             L+     ER++L +EL+E  +Q+      L+ +H  A + +E+ + +E +A E  L+++
Sbjct: 629  ALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKE 688

Query: 657  HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLL 716
             S  LQ     HR  ++    +  QELQ  R  ++ +   +L SLR EL+ Q AA     
Sbjct: 689  SSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAAC---- 744

Query: 717  RHNHHQELAAAKMELERSIDISRRQ--------SKEHI---------------------- 746
               H ++L A + EL     + R+Q        SK+HI                      
Sbjct: 745  -SGHQKDLEALQAELRA---LGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQG 800

Query: 747  ----CRI----TDLQEELRHREHHISELDKEVQHLHENISALTKELEF-KGKEILRIRSE 797
                C +      LQ+ +R     + +  +E Q L +    L +  +  + +E+  +R E
Sbjct: 801  SGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQE 860

Query: 798  SNQQIR-----------------------LEEMEEKYLMRESKPEDIQMITELKAMLTER 834
              ++++                       L++  EK     S+PED+Q+I  L+  L ER
Sbjct: 861  HRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKER 920

Query: 835  DQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVP 894
            + IIK+L E+ +F+     +  ++ N+ F+ +P  G + P  K+KK  D    +R VSVP
Sbjct: 921  EDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTPSMKKKKVED--VPSRVVSVP 978

Query: 895  NLSALESGGVGNGHPNRLD--PIPNSPVHDIE------FNSSKPLPQPVPPKGPKTFLSP 946
            NL++     +     +R++  PI  SP  D        +  ++        + P    + 
Sbjct: 979  NLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPNQSTDAKTATRTPDGETAQ 1038

Query: 947  AQSEASPVASPDPQRQEWFARYFTF 971
            A+       SP    QEWF +YF+F
Sbjct: 1039 AKEVQQKQGSP---HQEWFTKYFSF 1060



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 126/627 (20%), Positives = 264/627 (42%), Gaps = 95/627 (15%)

Query: 233 ALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNE 292
           AL ++  E E+ + A RE  Q++  + V +                        K+R+ +
Sbjct: 51  ALNTRQDEAEASMEALREAHQEELQNAVAET-----------------------KARLLQ 87

Query: 293 RLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEV 352
                EEE   L  + Q+L+       LEL+K++ E    +      E K  + R+E E 
Sbjct: 88  EQGCAEEEA--LLQRIQALESA-----LELQKRLTEEALAESASCRLETKERELRVEAEH 140

Query: 353 TQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ 412
            +     S+ + EL   +   ++ + S+    + +L  +  E         + +  Q  +
Sbjct: 141 AERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPE--------TKSEPGQGPE 192

Query: 413 ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD 472
             E L EV   +L   NQ++   +D  RK+E+       L A+ +   E ++  +   + 
Sbjct: 193 MQEVLLEV--QRLRVENQQLS--KDYARKAEE-------LQATYERENEAIRQAM---QQ 238

Query: 473 SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTE--NLRQECS 530
           S+ +        E +L +  Q  E  + A       +V K+  DLE +  +  +L++   
Sbjct: 239 SVSQALWQWQEKESDLRKNFQVQESALQA-------QVRKLEGDLEHRGRKISDLKKYAQ 291

Query: 531 KLREELRLQHEEDKKSAMSQLLQLKD-REKNAARDSWQKKVEDLLNQISLLKQNLEIQLS 589
           KL+E  R+Q  +         +QLK+ R++N+      KK+ +   ++++ K  + +Q  
Sbjct: 292 KLKE--RIQDLD---------VQLKEARQENSELKGTAKKLGE---KLAVAKDRMMLQEC 337

Query: 590 QSQTSLQQLQAQFTQERQRLTQE--LEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQR 647
           +       ++ +   E + L +E  LE      QQ    LKE   +   T + + +KE  
Sbjct: 338 RGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT-DMQTKKEAS 396

Query: 648 ALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASL---RSE 704
           A   +++Q++  +L+ +K    E  +  + ++ + L+ L  +   E K++ +S+   R +
Sbjct: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKK 456

Query: 705 LNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHIS 764
           L  +  A ++ +R    +E+   + E + ++++  + S   + R+ +  ++ + R     
Sbjct: 457 LQREVEAQLEEVRKKSEKEIKQLEEE-KAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAE 515

Query: 765 ELDKEVQHLHENI------SALTKELEFKGKEIL-RIRSESNQQIRLEEMEEKYLMRESK 817
           E  +E+   H +I           E   +G+E   ++ +E       EE  +  L   S 
Sbjct: 516 ESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSD 575

Query: 818 PEDIQMITELKAMLTERDQIIKKLIED 844
           P+       L ++L E+   I++L ED
Sbjct: 576 PQ-----PPLGSLLKEKTSKIQRLEED 597


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  160 bits (406), Expect = 4e-39
 Identities = 202/870 (23%), Positives = 390/870 (44%), Gaps = 155/870 (17%)

Query: 38   VEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQE 97
            ++E+RR   EK       Q   EK      E++   H  E QELL + ++    V++ QE
Sbjct: 1251 IDELRRSVSEKTAQIINTQ-DLEKSHTKLQEEIPVLH--EEQELLPNVKE----VSETQE 1303

Query: 98   KAEELHRMEVESLNK---MLEELRLERKKLIEDYEGKLNKAQSF-------------YER 141
               EL  +  +S  K    L  + +ER +L E ++    + +S               E 
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV 1363

Query: 142  ELDTLKRSQLFTAESLQAS----------KEKEADLRKEFQGQEAILRKTIGKLKTELQM 191
            + D LK     T   +Q S          KEK+ +  K     E    K    L+ E++M
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423

Query: 192  V---------QDEAGSLL---DKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 239
            +          DE  S+    D  Q+LQ          +VLQ + D  KE    +++KH 
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQ----------EVLQSESDQLKENIKEIVAKHL 1473

Query: 240  EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 299
            E E EL  A   L++Q              + T     V + + E+E S + ++L  + +
Sbjct: 1474 ETEEELKVAHCCLKEQ--------------EETINELRVNLSEKETEISTIQKQLEAIND 1519

Query: 300  ERAFLRSKTQSLDEEQKQ----QILELEKKVNEAKRTQQEYYERE--LKNLQSRLEEEVT 353
            +   L++K Q + E+++Q    QI E+++KVNE K+ ++    ++  L++++S++ E   
Sbjct: 1520 K---LQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTN 1576

Query: 354  QLNEAHSKTLEELAWKHHM-----AIEAVHSNAIRDKKKLQMDLEEQHNKD----KLNLE 404
            +L E+  +    +  K  M     A++        + K++   ++E   K+    K+   
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV 1636

Query: 405  EDKNQLQQELENLKEVLE-DKLNTANQEIGHLQ--DMVRKSEQGLGSAEGLIASLQDSQE 461
             +  +   E+E+LKE  E  KLN  N E  +++   ++ ++ + + S       L+  +E
Sbjct: 1637 NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696

Query: 462  RLQNELDLTKDSLKETKDALLNVEGELE---QERQQHEETIAAMK---EEEKLKVDKMAH 515
             L+ E D  K++L+ET    L  + EL+      ++H+ETI  ++    E+  ++  M  
Sbjct: 1697 TLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756

Query: 516  DLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLN 575
            DLE    + L+ +  K++EELR+ H           + LK++++    D  +  V +  +
Sbjct: 1757 DLEHS-NDALKAQDLKIQEELRIAH-----------MHLKEQQETI--DKLRGIVSEKTD 1802

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++S ++++LE   ++ Q  +Q+L+A    E Q +T     L++   +  K + E   L  
Sbjct: 1803 KLSNMQKDLENSNAKLQEKIQELKAN---EHQLIT-----LKKDVNETQKKVSEMEQLKK 1854

Query: 636  QTMEEEKEKEQRALEN-HLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEG 694
            Q  ++     +  +EN +L QK    L+ +K   +E     R+E     +TL+ E  D+ 
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE-----ETLKLE-RDQL 1908

Query: 695  KAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQE 754
            K  L                       QE  A  +E+++ +  +R  SKEH   +  L+E
Sbjct: 1909 KESL-----------------------QETKARDLEIQQELKTARMLSKEHKETVDKLRE 1945

Query: 755  ELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESN-QQIRLEEMEEKYLM 813
            ++  +   IS++ K++    + +    +EL+ K  ++LR++ + N    ++ EME+  L 
Sbjct: 1946 KISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ--LK 2003

Query: 814  RESKPEDIQMITELKAMLTERDQIIKKLIE 843
            ++ + +++ M    +++  +  Q+ KKL E
Sbjct: 2004 KQFEAQNLSM----QSVRMDNFQLTKKLHE 2029



 Score =  127 bits (319), Expect = 5e-29
 Identities = 195/914 (21%), Positives = 397/914 (43%), Gaps = 130/914 (14%)

Query: 37   EVEEIRRKFEEKLRSFGQLQVQFEK-----DKRLALEDLQAAHRREIQELLKSQQDHSAS 91
            E+  +R  ++  +  + QL+ + E+      ++  L++ +A  R+  ++  + Q  H  S
Sbjct: 499  ELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ-EMQLIHEIS 557

Query: 92   VNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYE-RELDTLKRSQ 150
              K   K  E++  ++E  N++  ++ L R+K     E ++ K Q + + ++L+ +K   
Sbjct: 558  NLKNLVKHAEVYNQDLE--NELSSKVELLREK-----EDQIKKLQEYIDSQKLENIKMDL 610

Query: 151  LFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTAL 210
             ++ ES++  K+ +  L   F  +   L       K E   ++ E   L +K ++L T  
Sbjct: 611  SYSLESIEDPKQMKQTL---FDAETVAL-----DAKRESAFLRSENLELKEKMKELATTY 662

Query: 211  AIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQA-SDLVLKASHIGML 269
               EN++Q+ Q QL+  K+ ++ L  + +   +E+      +  +   DL+      G +
Sbjct: 663  KQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKI 722

Query: 270  QATQ--MTQEV--------------TIKDLESEKSRVNERLSQLEEERAFLRSKTQSL-- 311
               Q  + +EV               +K L SE  R+ + +    EE   + S+   L  
Sbjct: 723  TDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS 782

Query: 312  ----DEEQKQQILELEKKVNEAKRTQQEYYE------RELKNLQSRLEEEVTQLNEAHSK 361
                 E + Q +LE   K  +   T Q  Y+      +  K L    E++   + E + +
Sbjct: 783  EVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER 842

Query: 362  TLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVL 421
              +E+    +++ EA   ++     K ++  + Q  ++K    +++     E+E LKE L
Sbjct: 843  MNQEIV---NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQER---LNEMEQLKEQL 896

Query: 422  EDK---LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETK 478
            E++   L T  +E   + + ++++ + + +       L+  QE LQ E D  K  + +T 
Sbjct: 897  ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV 956

Query: 479  DALLNVEGELE---QERQQHEETIAAMKEEEKLKVDKMAH-------------------- 515
            +  ++ + +L    +  +QH+ETI  +K +   +V +  H                    
Sbjct: 957  NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGID 1016

Query: 516  ---DLEIKWTENLRQECSK---LREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKK 569
               DLE K T+ L  +      + ++ ++     +K+ + Q+L+    EK   +   ++ 
Sbjct: 1017 KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKEN 1076

Query: 570  VE-DLLNQISL------LKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQ 622
            +E  + NQ  L      LK+  EI ++Q +    + + + ++   RL +  E+L+E+ QQ
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEI-VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135

Query: 623  RHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQE 682
              +  K+  +L  Q    E +K+   +EN   +  + EL        E ME  R+E+ Q+
Sbjct: 1136 LQE--KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELT------LEHMETERLELAQK 1187

Query: 683  LQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQS 742
            L     E++   K     +  EL        D LR  + +E+ A  ++ +  + I+    
Sbjct: 1188 LNENYEEVKSITKE--RKVLKELQKSFETERDHLR-GYIREIEATGLQTKEELKIAHIHL 1244

Query: 743  KEHICRITDLQEELRHREHHI----------SELDKEVQHLHE------NISALTKELEF 786
            KEH   I +L+  +  +   I          ++L +E+  LHE      N+  +++  E 
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304

Query: 787  KGK-EILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQI--IKKLIE 843
              + E+L  +S +     L  +E + L    K ++ Q   E+K++  ERD +  IK+ +E
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQ--EEIKSLTKERDNLKTIKEALE 1362

Query: 844  DNKFYQLELVNRET 857
              K  QL+   RET
Sbjct: 1363 -VKHDQLKEHIRET 1375



 Score =  127 bits (318), Expect = 7e-29
 Identities = 208/1043 (19%), Positives = 441/1043 (42%), Gaps = 176/1043 (16%)

Query: 6    LTEFEAYKHRV---EDMQLCAEAQHVQRIVT------------MSREVEEIRRKFEE--K 48
            L EFEA + +    ++MQL  E  +++ +V             +S +VE +R K ++  K
Sbjct: 534  LDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKK 593

Query: 49   LRSF--GQLQVQFEKDKRLALEDLQ----------------------AAHRREIQELLKS 84
            L+ +   Q     + D   +LE ++                      +A  R     LK 
Sbjct: 594  LQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKE 653

Query: 85   QQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDY---------------- 128
            +    A+  K  E   +L++ ++E+  KM  +L  E +    +                 
Sbjct: 654  KMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLL 713

Query: 129  -----EGKLNKAQSFYERELDTLK--RSQLFTAESLQASKEKEADLRKEFQGQEA---IL 178
                 EGK+   Q    +E++  +  R ++     L++   +   LRKE Q +     I+
Sbjct: 714  CNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHII 773

Query: 179  RKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKH 238
                 KL +E+   +     LL++  K +  LA  ++N +   ++  + K   M    K+
Sbjct: 774  TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY 833

Query: 239  KEV----------------------------ESELAAARERLQQQASDLVLKASHIGMLQ 270
            K V                            ++EL+   + LQ++  ++  + + +  L+
Sbjct: 834  KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893

Query: 271  ATQMTQEVTIKDLESEKSRVNERLSQ-------LEEERAFLRSKTQSLDEEQKQQILELE 323
                 ++ T++ +E EK+ + E+L Q       L +E+  L+   +SL  E+ Q   ++ 
Sbjct: 894  EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953

Query: 324  KKVNEAKRTQQE---------YYERELKNLQSRLEEEVTQ---LNEAHSKTLEELAWKHH 371
              VN    TQ++          ++  +  L+S++ EEV++   + E   +T +E   K  
Sbjct: 954  DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQK-M 1012

Query: 372  MAIEAVHSNAIRDKKKLQMDLEE----QHNKDKLNLEEDKNQLQQELENL---KEVLEDK 424
            + I+       ++ + L  D+++    +  +   +L ++KN+LQQ LE++   KE L+  
Sbjct: 1013 VGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTD 1072

Query: 425  LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNV 484
            L    +     Q+ +R     L   + ++A  ++   + + EL  T D L E ++ L   
Sbjct: 1073 LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132

Query: 485  EGELEQERQQHEETIAAMKEEEKL--KVDKMAHDLEIK--WTENLRQECSKLREELRLQH 540
              +L++++QQ       M E +K   +++ + ++L+ K    E++  E  +L ++L   +
Sbjct: 1133 SQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENY 1192

Query: 541  EEDKKSAMSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLE---IQLSQSQTSL 595
            EE  KS   +   LK+ +K+    RD  +  + ++       K+ L+   I L + Q ++
Sbjct: 1193 EE-VKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETI 1251

Query: 596  QQLQAQFTQERQRL--TQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 653
             +L+   +++  ++  TQ+LE+   + Q+    L E   L    ++E  E ++   E  L
Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL-LPNVKEVSETQETMNELEL 1310

Query: 654  QQKHSAELQSLKDAHRESMEGFRI-----EMEQELQTLRFELEDEGKAMLASLRSELNHQ 708
              + S    S   A R  ME  R+     E ++E+++L  E ++     L +++  L  +
Sbjct: 1311 LTEQSTTKDSTTLA-RIEMERLRLNEKFQESQEEIKSLTKERDN-----LKTIKEALEVK 1364

Query: 709  HAAAIDLLRHNHHQELA-AAKMELERSIDISRRQSKEHICRITDLQEELRHR-------E 760
            H    D L+ +  + LA   + + ++   ++ ++      +I    E+ + +       E
Sbjct: 1365 H----DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIE 1420

Query: 761  HHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQ-QIRLEEMEEKYLMRESK-- 817
              +  L K +Q  H+ + ++ KE +   +    ++SES+Q +  ++E+  K+L  E +  
Sbjct: 1421 IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELK 1480

Query: 818  ------PEDIQMITELKAMLTERD---QIIKKLIE------DNKFYQLELVNRETNFNKV 862
                   E  + I EL+  L+E++     I+K +E       NK  ++     + N  ++
Sbjct: 1481 VAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQI 1540

Query: 863  FNSSPTVGVINPLAKQKKKNDKS 885
                  V  +    + +K  D +
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSA 1563



 Score =  120 bits (301), Expect = 6e-27
 Identities = 192/917 (20%), Positives = 401/917 (43%), Gaps = 132/917 (14%)

Query: 8    EFEAYKHRVEDMQLCAEAQHVQRIVTMSR-EVEEIR--RKFEEKLRSFGQLQVQFEKDKR 64
            E    +  + +++L  E    +   T++R E+E +R   KF+E       L  + +  K 
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1356

Query: 65   LALEDLQAAH-------RREIQELLKSQQDHSASVNKGQE----------------KAEE 101
            +  E L+  H       R  + ++ +SQ     S+N  ++                K   
Sbjct: 1357 IK-EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSA 1415

Query: 102  LHRMEVE--SLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS-QLFTAESLQ 158
            L R+E+E   L+K L+E   E K + ++ +  L + Q   + E D LK + +   A+ L+
Sbjct: 1416 LLRIEIEMLGLSKRLQESHDEMKSVAKEKDD-LQRLQEVLQSESDQLKENIKEIVAKHLE 1474

Query: 159  ASKEKEADLRKEFQGQEAI--LRKTIGKLKTELQMVQDEAGSLLDKCQ-KLQTALAIAEN 215
              +E +       + +E I  LR  + + +TE+  +Q +  ++ DK Q K+Q    I E 
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE---IYEK 1531

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMT 275
              Q   KQ+ + +E ++  L + KE      +A + ++ +  +L  +      LQ +Q  
Sbjct: 1532 EEQFNIKQISEVQE-KVNELKQFKEHRKAKDSALQSIESKMLELTNR------LQESQEE 1584

Query: 276  QEVTIKDLESEKSRVNERLS----QLEEERAFLRSKTQSLDEEQKQ-----QILELEKKV 326
             ++ IK+ E E  RV E L     QL+E    + +K +   E++ Q      + E ++K+
Sbjct: 1585 IQIMIKEKE-EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643

Query: 327  NEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEEL--AWKHHMAIEAVHSNAIRD 384
             E +  ++++  ++L NL++ +E E  +L +   + LEE+    K    + +V      +
Sbjct: 1644 CEIEHLKEQFETQKL-NLEN-IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701

Query: 385  KKKLQMDLEEQHNKDKLNLEEDK------NQLQQELENLKEVLEDKLNTAN---QEIGHL 435
            + +L+ +L E   +D    EE K       + Q+ ++ L+ ++ +K N  +   +++ H 
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761

Query: 436  QDMVR------------------KSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKET 477
             D ++                  + ++ +    G+++   D    +Q +L+ +   L+E 
Sbjct: 1762 NDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEK 1821

Query: 478  KDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTE----NLRQECSKLR 533
               L   E +L   ++   ET   + E E+LK       L +   E    NL Q+  +  
Sbjct: 1822 IQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENL 1881

Query: 534  EELR-LQHEEDKKSAMSQLLQL-KDREKNAARDSWQKKVE---DLLNQISLLKQNLEI-- 586
            EE++ +  E D    + + L+L +D+ K + +++  + +E   +L     L K++ E   
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941

Query: 587  ----QLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEK 642
                ++S+    +  +Q    + +  L ++++EL+++  Q  +  ++ ++   +  E E+
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001

Query: 643  EKEQRALEN-HLQQKHSAELQSLKDAHRESMEGFRIEMEQ--ELQTLRFELEDEGKAMLA 699
             K+Q   +N  +Q       Q  K  H ES+E  RI  ++  EL+ ++  L+ E    +A
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLH-ESLEEIRIVAKERDELRRIKESLKMERDQFIA 2060

Query: 700  SLRSEL-----NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSK-----EHICRI 749
            +LR  +     NHQ      LL         + + +  R  ++ +R S+     E + R+
Sbjct: 2061 TLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRL 2120

Query: 750  T-DLQEELRHREH-----------------HISELDKEVQHLHENISALTKELEFKGKEI 791
            + DL++E+  ++                  HI +L    Q        + K+L++    +
Sbjct: 2121 SLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYV 2180

Query: 792  LRIRSESNQQIRLEEME 808
             +I+ E ++ I   EM+
Sbjct: 2181 TKIKEEQHESINKFEMD 2197



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 176/904 (19%), Positives = 370/904 (40%), Gaps = 169/904 (18%)

Query: 3    QQALTEFEAYKHRVEDMQLCAEAQHVQR---------IVTMSREVEEIRRKF-------- 45
            Q++  E +      E+M+   EA  ++R         IV   +E +E   +F        
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638

Query: 46   -EEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQE---KAEE 101
             +EK+     L+ QFE  K L LE+++  + R + ++L    +   SV K ++     EE
Sbjct: 1639 TQEKMCEIEHLKEQFETQK-LNLENIETENIR-LTQILHENLEEMRSVTKERDDLRSVEE 1696

Query: 102  LHRMEVESLNKMLEEL------RLERKKLI----EDYEGKLNKAQSFYERELDTLKRSQL 151
              ++E + L + L E       + E  K++    ++++  ++K +     + + +   Q 
Sbjct: 1697 TLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK 1756

Query: 152  FTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 211
                S  A K ++  +++E       LR     LK + + +    G + +K  KL     
Sbjct: 1757 DLEHSNDALKAQDLKIQEE-------LRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVES--ELAAARERLQQQASD--LVLKASHIG 267
              EN+   LQ+++ + K  E  L++  K+V    +  +  E+L++Q  D  L L    I 
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE 1869

Query: 268  MLQATQMTQEVTIKDLESEKSRVNER--LSQLEEERAFLRSKTQSLDEEQKQQILELEKK 325
             L   Q   E    +LE  KS + ER  L ++EE     R + +   +E K + LE++++
Sbjct: 1870 NLNLAQKLHE----NLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE 1925

Query: 326  VNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 385
            +  A+   +E+ E  +  L+ ++ E+  Q+++                   +  +  + K
Sbjct: 1926 LKTARMLSKEHKET-VDKLREKISEKTIQISD-------------------IQKDLDKSK 1965

Query: 386  KKLQMDLEEQHNKDK--LNLEEDKNQLQQ---ELENLKEVLE-DKLNTANQEIGHLQDMV 439
             +LQ  ++E   K+   L ++ED N   +   E+E LK+  E   L+  +  + + Q + 
Sbjct: 1966 DELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQ-LT 2024

Query: 440  RKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETI 499
            +K  + L     ++A  +D   R++  L + +D    T   ++       ++RQ H+   
Sbjct: 2025 KKLHESLEEIR-IVAKERDELRRIKESLKMERDQFIATLREMI------ARDRQNHQ--- 2074

Query: 500  AAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREK 559
              +K E++L  D   H      TE+LR++CS+++E L+   E D        L L   ++
Sbjct: 2075 --VKPEKRLLSDGQQH-----LTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127

Query: 560  NAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQ 619
               +     +V+  L+   L  +++E   + +Q    +      + +  L+   +  EEQ
Sbjct: 2128 IEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQ 2187

Query: 620  HQQRHK---------SLKEAHVLAFQTMEEEKEKEQRAL-------------ENHLQQKH 657
            H+  +K           ++  ++  Q ++++ +   R L             E  L+   
Sbjct: 2188 HESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFS 2247

Query: 658  SAELQSLKDAHRESMEGFRIEMEQELQ---TLRFELE------DEGKAMLASLRSELNHQ 708
             +E  S+K   ++ +   R EM Q L+     RF++E       +    +  + +  N++
Sbjct: 2248 ESEFPSIKTEFQQVLSN-RKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNR 2306

Query: 709  HAAAID----------LLRHNHHQELAAAKMELE-------------------------- 732
              A ++           +     Q+L + K + E                          
Sbjct: 2307 IIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN 2366

Query: 733  -------RSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELE 785
                   R+  ++  + +E    + + +E   H+E  I ++ KE++  ++ I+ L  ++ 
Sbjct: 2367 KNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVH 2426

Query: 786  FKGK 789
               K
Sbjct: 2427 ESNK 2430



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 85/411 (20%), Positives = 168/411 (40%), Gaps = 39/411 (9%)

Query: 38   VEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRRE--IQELLKSQQDHSASVNKG 95
            ++E+ ++ +E L     LQ   +   R  L DL+     +  I+E+LK   +      K 
Sbjct: 2199 IDEVEKQ-KELLIKIQHLQQDCDVPSR-ELRDLKLNQNMDLHIEEILKDFSESEFPSIKT 2256

Query: 96   QEKAEELHRMEVESLNKMLEELRLERKKL---IEDYEGKLNKAQSFYE-RELDTLKRSQL 151
            + +    +R E+    +     R + +KL   I+    ++ +  +F+  R +  +  S  
Sbjct: 2257 EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTE 2316

Query: 152  FTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALA 211
            F   S   SKE E DL+   +  E +  K    LKT L        +  D      T+ A
Sbjct: 2317 FEERSATISKEWEQDLKSLKEKNEKLF-KNYQTLKTSLASGAQVNPTTQDNKNPHVTSRA 2375

Query: 212  --IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML 269
              +    ++ L+  L +AKE  M   SK  +++ EL        +  +D++ K      +
Sbjct: 2376 TQLTTEKIRELENSLHEAKESAMHKESKIIKMQKEL--------EVTNDIIAKLQ--AKV 2425

Query: 270  QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA 329
              +    E T + ++  + +V       +EE   L+ K   +D E+ +   E EK+++  
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISAT 2485

Query: 330  KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQ 389
            K T +  Y++E+  L   L E + +  +A              ++ + H++     K L 
Sbjct: 2486 KATVE--YQKEVIRL---LRENLRRSQQAQD-----------TSVISEHTDPQPSNKPLT 2529

Query: 390  MDLEE--QHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDM 438
                     N   L L+ +  +L++E+  LK+  E  +   N+ + + Q +
Sbjct: 2530 CGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL 2580



 Score = 30.4 bits (67), Expect = 8.4
 Identities = 27/128 (21%), Positives = 61/128 (47%), Gaps = 6/128 (4%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 95
            RE+E    + +E         ++ +K+  +   D+ A  + ++ E  K  +    ++   
Sbjct: 2384 RELENSLHEAKESAMHKESKIIKMQKELEVT-NDIIAKLQAKVHESNKCLEKTKETIQVL 2442

Query: 96   QEKAE---ELHRMEVESLNKMLEELRLERKKLIEDYEGKLN--KAQSFYERELDTLKRSQ 150
            Q+K     + ++ E+E L   L ++ LE+ K  +++E +++  KA   Y++E+  L R  
Sbjct: 2443 QDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLREN 2502

Query: 151  LFTAESLQ 158
            L  ++  Q
Sbjct: 2503 LRRSQQAQ 2510


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1609 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1777

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1818

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2055

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2114

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2172

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2173 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2283

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2370



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 1968 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 2021

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2075

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2312 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2368 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2427 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2481

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2482 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2596

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2597 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2656

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2657 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2716

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2717 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2776

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2777 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2819



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1358 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1653

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1772

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1833 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1892

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 1893 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 2010 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2058

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2059 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 990  KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1044

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1104

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1105 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1163

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1344 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1392

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1447

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1448 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1502 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1616

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1617 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1671 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1723

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1759


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1613 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1781

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1822

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1823 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1882

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 1883 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2002

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 2003 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2059

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2118

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2176

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2177 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2234

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2287

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2346

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2374



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 1972 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 2025

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2079

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2316 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2371

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2372 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2431 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2485

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2486 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2600

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2601 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2660

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2661 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2720

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2721 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2780

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2781 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2823



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1362 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1417

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1657

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1776

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1837 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1896

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 1897 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 2014 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2062

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2063 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2115

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2235

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2236 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2272



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 994  KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1048

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1049 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1108

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1109 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1167

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1168 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1227

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1228 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1287

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1347

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1348 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1396

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1397 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1451

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1452 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1505

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1506 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1620

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1621 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1675 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1727

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1763


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1609 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1777

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1818

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1998

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 1999 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2055

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2114

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2172

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2173 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2283

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2342

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2370



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 1968 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 2021

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2075

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2312 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2367

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2368 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2427 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2481

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2482 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2596

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2597 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2656

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2657 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2716

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2717 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2776

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2777 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2819



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1358 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1653

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1772

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1833 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1892

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 1893 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 2010 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2058

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2059 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 990  KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1044

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1045 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1104

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1105 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1163

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1164 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1223

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1343

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1344 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1392

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1447

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1448 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1501

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1502 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1616

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1617 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1671 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1723

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1759


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1577 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1745

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1786

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1787 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1846

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 1847 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1966

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 1967 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2023

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2082

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2140

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2141 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2198

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2251

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2310

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2338



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 1936 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 1989

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2043

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2280 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2335

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2336 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2395 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2449

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2450 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2564

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2565 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2624

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2625 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2684

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2685 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2744

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2745 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2787



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1326 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1381

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1621

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1740

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1801 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1860

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 1861 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 1978 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2026

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2027 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2079

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2199

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2200 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2236



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 958  KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1012

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1013 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1072

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1073 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1131

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1132 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1191

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1192 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1251

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1311

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1312 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1360

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1361 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1415

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1416 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1469

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1470 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1584

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1585 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1639 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1691

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1727


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1746 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1914

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1955

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 2015

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 2016 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2135

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 2136 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2192

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2251

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2309

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2310 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2367

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2420

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2479

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2507



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 2105 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 2158

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2212

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2449 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2504

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2505 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2564 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2618

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2619 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2733

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2734 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2793

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2794 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2853

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2854 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2913

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2914 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2956



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1495 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1550

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1551 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1790

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1909

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1970 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 2029

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 2030 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 2147 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2195

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2196 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2248

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2368

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2369 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 1127 KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1181

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1182 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1241

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1242 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1300

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1301 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1360

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1361 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1420

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1480

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1481 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1529

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1530 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1584

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1585 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1638

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1639 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1753

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1754 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1808 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1860

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1896


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1587 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1755

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1796

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1856

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 1857 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1976

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 1977 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2033

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2034 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2092

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2150

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2151 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2208

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2209 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2261

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2320

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2348



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 1946 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 1999

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2053

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2290 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2345

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2346 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2405 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2459

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2460 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2574

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2575 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2634

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2635 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2694

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2695 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2754

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2755 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2797



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1336 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1391

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1392 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1511

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1631

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1750

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1811 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1870

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 1871 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 1988 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2036

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2037 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2089

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2209

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2210 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2246



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 968  KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1022

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1023 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1082

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1083 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1141

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1142 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1201

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1202 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1261

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1321

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1322 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1370

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1371 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1425

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1426 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1479

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1480 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1535

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1594

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1595 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1649 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1701

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1737


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1535 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1594

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1595 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1763

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1804

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1864

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 1865 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1984

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 1985 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2041

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2042 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2100

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2158

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2159 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2216

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2217 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2269

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2328

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2356



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 1954 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 2007

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2061

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2241

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2298 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2353

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2354 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2413 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2467

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2468 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2582

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2583 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2642

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2643 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2702

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2703 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2762

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2763 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2805



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1344 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1399

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1400 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1459

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1519

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1639

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1758

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1819 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1878

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 1879 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 1996 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2044

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2045 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2097

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2217

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2218 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2254



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 976  KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1030

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1031 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1090

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1091 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1149

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1150 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1209

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1210 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1269

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1329

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1330 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1378

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1379 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1433

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1434 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1487

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1488 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1543

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1602

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1603 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1657 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1709

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1745


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  156 bits (394), Expect = 1e-37
 Identities = 217/928 (23%), Positives = 406/928 (43%), Gaps = 110/928 (11%)

Query: 2    KQQALTEFEAYKHRVED-------------MQLCAEAQHVQRIVTMSREVEEIRRKFEEK 48
            K+QA  E E  + +V+D              ++ AEA+  +      + +EE+R + EE 
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575

Query: 49   LRSFGQLQVQFEKDKRLALEDLQAAHRREIQ-----------ELLKSQQDHSASVNKGQE 97
             R   Q +V+  +  ++ALE  Q +   E+Q           +L +S Q+   +V + +E
Sbjct: 1576 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1635

Query: 98   KAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
            +AE   + + E+     E  R E ++ +E ++ K N+A     +  +  ++  L  AE+ 
Sbjct: 1636 EAERRAQQQAEA-----ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690

Query: 158  QASKEKEADLRKEFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQ---KLQTALA 211
            +  +E E + R+  + +E  +R+      +L+ + Q+ +  A   L   Q   +L+    
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750

Query: 212  IAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQA 271
              E   Q+L+++L   +    A   K +E+E+ELA  R  ++      VL AS     + 
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME------VLLASKARAEEE 1804

Query: 272  TQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR 331
            ++ T E + + LE+E  R  E    L EE A LR    +L EE K+Q           ++
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRE----LAEEAARLR----ALAEEAKRQ-----------RQ 1845

Query: 332  TQQEYYERELKNLQSRLEEEVTQLNEA-HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
              +E   R+    +  L E++  + EA   KT  E+A K   A          D+   + 
Sbjct: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1905

Query: 391  DLEEQHNKDKLNLEEDKNQLQQ----ELENLKEVLEDKLNTANQ---EIGHLQDMVRKSE 443
             LEEQ  + K ++EE   QL++    ELE  K ++ED L    Q   EI  L+    K+ 
Sbjct: 1906 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965

Query: 444  QG-------LG----SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQER 492
             G       LG    +AE  + S + ++     +  L  +  +  ++A   V+  L  E 
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2025

Query: 493  QQHEETIAAMKEEEKL--KVDKMAHDLEIKWTENLRQ-ECSKLREELRLQHEEDKKSAMS 549
            +   +  AA++E E+L  KV++     E    E+ RQ + ++   + RLQ EE    A +
Sbjct: 2026 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE---KAHA 2082

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQER 606
              +Q K++E        Q  ++ L  +    ++  E +  +++   ++  AQ     +E 
Sbjct: 2083 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEA 2141

Query: 607  QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
            +RL Q  EE  +   Q   + ++    A Q      + EQ AL    +Q   AE++  K 
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--KQAADAEMEKHKK 2199

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH--HQEL 724
               +++   + ++EQEL TLR +LE E       L  EL    A A +  R      +EL
Sbjct: 2200 FAEQTLRQ-KAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2257

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
             + ++++E    +  R   E+   I      LR +++    L +E + + + ++     L
Sbjct: 2258 FSVRVQMEELSKLKARIEAENRALI------LRDKDNTQRFLQEEAEKM-KQVAEEAARL 2310

Query: 785  EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKA---MLTERDQI---- 837
                +E  R+R  + + +  +    + +++E K + +Q  T LKA   +L ++ ++    
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKE-KMQAVQEATRLKAEAELLQQQKELAQEQ 2369

Query: 838  IKKLIEDNKFYQLELVNRETNFNKVFNS 865
             ++L ED +    +L      F +   +
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEA 2397



 Score =  142 bits (358), Expect = 2e-33
 Identities = 205/943 (21%), Positives = 407/943 (43%), Gaps = 100/943 (10%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVE----EIRRKFEEKLRSFGQLQV 57
            +Q+ L E    + R  + ++ A     ++      E+E     IR   E+ LRS  Q ++
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            +  + ++LA E+ +   RRE +E  + Q+  +A     +++   L   EVE L   +EE 
Sbjct: 1995 EAARQRQLAAEEER--RRREAEE--RVQKSLAAEEEAARQRKAALE--EVERLKAKVEEA 2048

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            R  R++  ++   +L  AQ   ++ L   +++  F      A ++KE +L++  Q ++++
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF------AVQQKEQELQQTLQQEQSV 2102

Query: 178  LRKTIGKLKTELQMVQD-EAGSLLDKCQKLQTALAI--AENNVQVLQKQLDDAKEGEMAL 234
            L +  G+ +   +  ++ E   +  + +  Q+   +  AE   Q  ++Q     + + A 
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162

Query: 235  LSKHKEVESELAAARER-----LQQQASDLVL----KASHIGMLQATQMTQEVT-----I 280
                KE E E A   +       Q+QA+D  +    K +   + Q  Q+ QE+T     +
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222

Query: 281  KDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ---KQQILELEKKVNEAKRTQQEYY 337
            ++ + +K+ ++E L +L+ E      +   ++EE    + Q+ EL K     +   +   
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQH 396
             R+  N Q  L+EE  ++ +      EE A     A EA     + ++   Q   L E+ 
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQV----AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338

Query: 397  NKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQ-DMVRKSEQGLGSAEGLIAS 455
             K+K+   ++  +L+ E E    +L+ +   A ++   LQ D  + ++Q     +G   +
Sbjct: 2339 LKEKMQAVQEATRLKAEAE----LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2394

Query: 456  LQDSQERLQNELDLTKDSLK----ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
            L+  ++R Q E+    + LK    E   A    E + ++ R+Q EE    +   E    +
Sbjct: 2395 LEAERQR-QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2453

Query: 512  K--MAHDLEIKWTENLRQECSKLREEL-RLQHEEDKKSAMSQLLQLKDREKNAARDSWQK 568
            K  +   LEI+  ++   +  +LRE +  L+ E++K    ++LLQLK  E    +     
Sbjct: 2454 KVTLVQTLEIQRQQS-DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ---- 2508

Query: 569  KVEDLLNQISLLKQNL---EIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHK 625
              E LL +   L+Q+    +  L Q +  ++Q +A+  Q  Q    + ++L E+ Q++ +
Sbjct: 2509 --EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566

Query: 626  SLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQT 685
             +++       +MEE + ++  A E    ++   ELQ L+   R+  E    E  Q L+ 
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEG--VRRKQEELQQLEQQRRQ-QEELLAEENQRLRE 2623

Query: 686  LRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ---- 741
                LE++ +A LA        Q AA   L       +  AA+ E E S D  RR+    
Sbjct: 2624 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ 2683

Query: 742  ---------------------SKEHICRITDLQEELRHREHHISELDKEVQHLHENISAL 780
                                 + + + R  D++  L+ R      L K         +AL
Sbjct: 2684 RLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAAL 2743

Query: 781  TKELEFKGKEILRIRSESNQQIRLEEMEEKYL-MRESKPEDI-------QMITELKAMLT 832
             ++L   G  ++ + +++     L+ +  + L + E+  E +       ++++  +A+  
Sbjct: 2744 QRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTG 2803

Query: 833  ERDQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPL 875
             +D    + I   +  Q  L+ RE     +     T GVI+P+
Sbjct: 2804 YKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPV 2846



 Score =  127 bits (318), Expect = 7e-29
 Identities = 211/937 (22%), Positives = 386/937 (41%), Gaps = 138/937 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            +++ L E EA    +E  +  AEA H Q      RE +E++++ +E++    +  V  ++
Sbjct: 1385 ERERLAEVEA---ALEKQRQLAEA-HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1440

Query: 62   DKRLALEDLQ------------------AAHRR--------------------------- 76
             KR   E+LQ                  AA R                            
Sbjct: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHR-MEVESLNKMLEELRLER--KKLIEDYEGKLN 133
            E+Q L    ++  A   + QE+AE L R ++ ES  K   E+ L    K   E    K  
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560

Query: 134  KAQSFYERELDT------LKRSQLFTAESLQASKE-KEADLRKEFQGQEAILRKTIGKLK 186
              Q+  E  L        L+++++  A  +Q + E  +     E Q + A   +   +L+
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLD--DAKEGE-MALLSKHKEVES 243
              LQ        L ++ ++     A AE   +  +++L+    K  E + L  + +EV  
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1680

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQ-EVTIKDLESEKSRVNERLSQ-LEEER 301
            + + A+   ++Q  +   +A   G  +   + Q E+  ++LE ++        Q L  E+
Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740

Query: 302  AFLRSKTQSLDEEQKQQILE-----LEKKVNEAKRTQQEYYERELKNL----------QS 346
              +R + ++   EQ++Q+LE     L+++   A + +QE  E EL  +          ++
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE-LEAELAKVRAEMEVLLASKA 1799

Query: 347  RLEEEVTQLNEAHSKTLEELAWK-HHMAIEAVHSNAIRDKKKLQMDL-EEQHNKDKLNLE 404
            R EEE    +E   + LE  A +   +A EA    A+ ++ K Q  L EE   + +   E
Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859

Query: 405  E---DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVR-KSEQGLGSAEGLIASLQDSQ 460
                +K     E   LK   E  L     E   L+ +   ++ Q     E       D +
Sbjct: 1860 RVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE 1919

Query: 461  ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIK 520
            ERL  +L    DS  E +  L  VE  L Q RQ  EE +A     EK    K   +LE+ 
Sbjct: 1920 ERLA-QLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976

Query: 521  WTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN-----AARDSWQKKVEDLLN 575
               +  ++  + +E+  L+    ++ A  +  + ++ E+      AA +   ++ +  L 
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036

Query: 576  QISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAF 635
            ++  LK  +E          ++L+ +  QE  R   +L+  +E  Q+R ++ ++AH  A 
Sbjct: 2037 EVERLKAKVE--------EARRLRERAEQESAR---QLQLAQEAAQKRLQAEEKAHAFAV 2085

Query: 636  QTMEEEKEKEQRALENHLQQKHSA--ELQSLKDAHR---ESMEGFRIEMEQELQTLRFEL 690
            Q  E+E       L+  LQQ+ S   +L+   +A R   E  E  R++ E+E    R ++
Sbjct: 2086 QQKEQE-------LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2138

Query: 691  ED-EGKAMLASLRSELNHQHAAAIDLLRHNHHQELA--------------AAKMELERS- 734
            E+ E     A  +++   Q  AA + LR    QE A              AA  E+E+  
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198

Query: 735  --IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEIL 792
               + + RQ  +    +T L+ +L   +H  + LD+E+Q L    +   ++     +E+ 
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2258

Query: 793  RIRSESNQQIRLE---EMEEKYLMRESKPEDIQMITE 826
             +R +  +  +L+   E E + L+   K    + + E
Sbjct: 2259 SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2295



 Score =  110 bits (275), Expect = 6e-24
 Identities = 192/817 (23%), Positives = 353/817 (43%), Gaps = 91/817 (11%)

Query: 61   KDKRLALE--DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
            KD RL LE  + +  HR  +  L K      A     Q+KA+     EVE L K +  L 
Sbjct: 1017 KDIRLQLEACETRTVHRLRLP-LDKEPARECAQRIAEQQKAQA----EVEGLGKGVARLS 1071

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLR-KEFQGQEAI 177
             E +K++   E          E EL   K  Q+ +  ++   K K   L  +  QG E +
Sbjct: 1072 AEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEV 1131

Query: 178  LRKTIGKLKTELQMVQ---DEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
            LR    +LK E Q V     E  +     +KL+      +     L+ +L  A+E    L
Sbjct: 1132 LRAHEEQLK-EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERL 1190

Query: 235  LSKHKEVESELAAARERLQQ--QASDLVLKASHIGMLQATQMTQEVTI--KDLESEKSRV 290
              +H E + E+   RER+ Q  +    VL  + +   +  Q+ +++    +  +   + +
Sbjct: 1191 QQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWL 1250

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEK------KVNEAKRTQQEY------YE 338
             +   + E+ +A   + +Q++ E+ +Q+   LE+      KV E +R  ++Y      YE
Sbjct: 1251 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1310

Query: 339  RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK 398
             +L   +++LE   +   +   ++  E   + ++ +   +S       +    + E   +
Sbjct: 1311 LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1370

Query: 399  DKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
             +   EE++   QQ  E  + + E +     Q     + +     Q    AE      ++
Sbjct: 1371 ME---EEERLAEQQRAEERERLAEVEAALEKQ-----RQLAEAHAQAKAQAE---REAKE 1419

Query: 459  SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
             Q+R+Q E+   +++  + +    +++ EL+Q RQ  E  I A     K +  + A    
Sbjct: 1420 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA-----KARQAEAAERSR 1474

Query: 519  IKWTENLRQECSKLREELRLQHEEDKKSAMS---QLLQLKDREKNAARDSWQKKVEDLLN 575
            ++  E +R         L+L+  E ++       Q L+ +  E  A +   Q++ E L  
Sbjct: 1475 LRIEEEIRVV------RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRR 1528

Query: 576  QI---SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHV 632
            Q+   S  K+  E++L+    S  + +A+  +E+QR  Q LEEL  Q ++  + L++A V
Sbjct: 1529 QVQDESQRKRQAEVELA----SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1584

Query: 633  LAFQTMEEEKEKEQRALENHLQQKH------SAELQ-SLKDAH------RESMEGFRIEM 679
               + ++   E  QR+ E  LQ K       +A+L+ SL++ H      RE  E  R + 
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAER-RAQQ 1643

Query: 680  EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
            + E +  R E E E +      R +L    A  + L      Q+ + A+ E E+  + + 
Sbjct: 1644 QAEAERAREEAERELE------RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697

Query: 740  RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSES- 798
            R+++    R    ++ +R RE    EL+K+ Q L E  +      E   +E++R+R+E+ 
Sbjct: 1698 REARR---RGKAEEQAVRQRELAEQELEKQRQ-LAEGTAQQRLAAE---QELIRLRAETE 1750

Query: 799  --NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE 833
               QQ +L E E   L RE+     Q   EL+A L +
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAA-TQKRQELEAELAK 1786


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  154 bits (389), Expect = 4e-37
 Identities = 206/917 (22%), Positives = 388/917 (42%), Gaps = 116/917 (12%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQR----IVTMSRE--VEEIRRKFEEKLRSFGQL 55
            K + L + E  K +VED+Q   E + + +    + T+S +  + E+ +    +++   +L
Sbjct: 424  KVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAEL 483

Query: 56   QVQFEKDKRLALEDLQAAHRREIQELLK----SQQDHSASVNKGQE---KAEELHRMEV- 107
            + + E +K     D+  +  +EI  L +    ++ DH   +   +E     EE H+ E+ 
Sbjct: 484  RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 543

Query: 108  -------------ESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTA 154
                         ESL   LE    E   +I  ++ KL  A + +++ ++ LK S    +
Sbjct: 544  ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS---FS 600

Query: 155  ESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQ-KLQTALAIA 213
            + L     + A+L+ + +      +  I  L+ +    +      ++  + KL   +   
Sbjct: 601  KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660

Query: 214  ENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQ 273
            EN+++ ++ +LD A++  +       E+E  L     +LQ+      +K   + +LQA  
Sbjct: 661  ENSLEAIRSKLDKAEDQHLV------EMEDTL----NKLQEAE----IKVKELEVLQAKC 706

Query: 274  MTQEVTIKDLESEKSRVNERLSQLE-------EERAFLRSKTQSLDEEQKQ-QILELEKK 325
              Q   I +  S+     E+L  L+       E ++ ++   Q L+  +KQ + LE+EK 
Sbjct: 707  NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 766

Query: 326  VNEAKRTQ--QEYYERELK--NLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNA 381
               +K +   +E   RELK  NLQ  L  EV+Q+ E   K L+ L  K   A E     A
Sbjct: 767  AESSKASSITRELQGRELKLTNLQENL-SEVSQVKETLEKELQILKEKFAEASE----EA 821

Query: 382  IRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRK 441
            +  ++ +Q  + + H K     EE  N L  +LE L+E L D +    +E    ++ + K
Sbjct: 822  VSVQRSMQETVNKLHQK-----EEQFNMLSSDLEKLRENLAD-MEAKFREKDEREEQLIK 875

Query: 442  SEQGL-----------GSAEGLIASLQDS---QERLQNELDLTKDSLKETKDALLNVEGE 487
            +++ L           G     +  + D    +ER   EL L      E    L     +
Sbjct: 876  AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 935

Query: 488  LEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLR-------EELRLQH 540
            +  + +Q ++  A   EEEK ++++   DLE K  E    +C +L+        E + +H
Sbjct: 936  MTVKAEQSQQEAAKKHEEEKKELERKLSDLE-KKMETSHNQCQELKARYERATSETKTKH 994

Query: 541  EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQI-SLLKQNLEIQLSQSQTSLQQLQ 599
            EE  ++    LL  +D+ K A  ++       LL ++  L KQ  + + +Q+     Q+ 
Sbjct: 995  EEILQNLQKTLLDTEDKLKGAREEN-----SGLLQELEELRKQADKAKAAQTAEDAMQIM 1049

Query: 600  AQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE-EKEKEQRALENHLQQKHS 658
             Q T+E+      LE+ ++ + +    L        + +EE  K KE   +EN   ++  
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109

Query: 659  AELQSLKDAHRE------SMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA 712
             E+++LK A  +      +++   +++ +EL   R E+    K  L   RS LN+Q    
Sbjct: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSVLNNQ-LLE 1166

Query: 713  IDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEE---LRHREHHISELDKE 769
            +        ++    K  L++SI I+     E    +  L+ E   LR        L   
Sbjct: 1167 MKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSV 1226

Query: 770  VQHLHEN---ISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITE 826
            VQ L  +   +    K LE + KE  R  S S+     +  E++     ++   I  +  
Sbjct: 1227 VQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDE----RAQESQIDFLNS 1282

Query: 827  LKAMLTERDQIIKKLIE 843
            +   L  ++Q +K  +E
Sbjct: 1283 VIVDLQRKNQDLKMKVE 1299



 Score =  127 bits (318), Expect = 7e-29
 Identities = 160/751 (21%), Positives = 340/751 (45%), Gaps = 94/751 (12%)

Query: 31   IVTMSREVEEIRRKFEEKLRS----FGQLQVQFEK---DKRLALEDLQ-------AAHRR 76
            I +  + +EE++  F + L +    F +L+ Q EK   D +  +E+LQ       AAH +
Sbjct: 585  IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 644

Query: 77   EIQEL-------LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYE 129
            E++ L       +K +++   ++    +KAE+ H +E+E     L+E  ++ K+L E  +
Sbjct: 645  EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL-EVLQ 703

Query: 130  GKLNKAQSFYERELDTLKRSQ--LFTAESLQ-ASKEKEADLRKEFQGQEAILRKTIGKLK 186
             K N+     +     LK ++  L   ++L+ AS E +++++K  Q  EA   K I  L+
Sbjct: 704  AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA-EKQIKHLE 762

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLS-KHKEVESEL 245
             E      +A S+  + Q  +  L   + N+  +  Q+ +  E E+ +L  K  E   E 
Sbjct: 763  IEKNAESSKASSITRELQGRELKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEA 821

Query: 246  AAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLR 305
             + +  +Q+  + L  K     ML +        + D+E++    +ER  QL + +  L 
Sbjct: 822  VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE 881

Query: 306  SKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQ-----SRLEEEVTQLNEAHS 360
            +    + +       +L K  +E +  +++  E +LK  +     S L++ +  +     
Sbjct: 882  NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE 941

Query: 361  KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHN-------KDKLNLEEDKNQLQQE 413
            ++ +E A KH    E       R    L+  +E  HN       + +    E K + ++ 
Sbjct: 942  QSQQEAAKKH----EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI 997

Query: 414  LENLKEVL---EDKLNTANQEIGHL--------------------QDMVRKSEQGLGSAE 450
            L+NL++ L   EDKL  A +E   L                    +D ++  EQ      
Sbjct: 998  LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057

Query: 451  GLIASLQDSQE---RLQNELD-LTKDSLKETKD-----ALLNVEGELEQERQQHEETIAA 501
              +ASL+D+++   +LQNELD L +++LK  ++      LL VE +  +E ++  ET+  
Sbjct: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117

Query: 502  MKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA 561
               ++  ++  +  +  +K  E L +   ++    +L  EE++    +QLL++K RE   
Sbjct: 1118 AAAQKSQQLSALQEE-NVKLAEELGRSRDEVTSHQKL--EEERSVLNNQLLEMKKRESKF 1174

Query: 562  ARDSWQKKVEDLLNQIS-----LLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEEL 616
             +D+ ++K   L   IS     L +++ E++  +++ ++ + +    +    + Q LE  
Sbjct: 1175 IKDADEEKA-SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESD 1233

Query: 617  EEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFR 676
            + + + + K+L+         ++ ++ K Q +  +      + E +  +++  + +    
Sbjct: 1234 KVKLELKVKNLE---------LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1284

Query: 677  IEMEQELQTLRFELEDEGKAMLASLRSELNH 707
            ++++++ Q L+ ++E   +A L     +LN+
Sbjct: 1285 VDLQRKNQDLKMKVEMMSEAALNGNGDDLNN 1315



 Score =  122 bits (307), Expect = 1e-27
 Identities = 157/677 (23%), Positives = 282/677 (41%), Gaps = 100/677 (14%)

Query: 206 LQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK-EVESELAAARERLQQQASDLVLKAS 264
           LQ AL   + +++ L  + D  +  E+A  + H  E+E ELA AR+   Q   +L  K  
Sbjct: 353 LQEALKEKQQHIEQLLAERD-LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD 411

Query: 265 HI-GMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELE 323
            +  M++A    +   +  LE EK +V +   ++EEE +  +   +     +K +I+ELE
Sbjct: 412 QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE-SITKGDLEVATVSEKSRIMELE 470

Query: 324 K----KVNEAKRTQQEYYE--------------RELKNLQSRLE-------EEVTQLNEA 358
           K    +V E    ++                  +E+ +LQ +LE        E+T L E 
Sbjct: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE- 529

Query: 359 HSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE--EQHNKDKLNLEEDKNQL-----Q 411
           H    EE   K   A+        ++ + L+  LE   + N D + L + K +      Q
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQ 589

Query: 412 QELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ-NELDLT 470
           Q +E LK      L T   E   L+  + K           + + QDS+      E++  
Sbjct: 590 QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649

Query: 471 KDSL----KETKDALLNVEGELEQERQQH----EETIAAMKEEEKLKVDKMAHDLEIKWT 522
           +  L    KE +++L  +  +L++   QH    E+T+  ++E E          +++K  
Sbjct: 650 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAE----------IKVKEL 699

Query: 523 ENLRQECSKLREELRLQHEEDKKSAMSQLLQLKD-REKNAARDSWQKKVEDLLNQISLLK 581
           E L+ +C++  + +        K+   +LL L   R+ ++   S  KK+   L       
Sbjct: 700 EVLQAKCNEQTKVID-NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758

Query: 582 QNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVL--AFQTME 639
           ++LEI+ +   +    +  +      +LT   E L E  Q +    KE  +L   F    
Sbjct: 759 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818

Query: 640 EEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLA 699
           EE    QR+++  + + H  E            E F + +  +L+ LR  L D    M A
Sbjct: 819 EEAVSVQRSMQETVNKLHQKE------------EQFNM-LSSDLEKLRENLAD----MEA 861

Query: 700 SLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR 759
             R              +    ++L  AK +LE  I    + S ++  ++T + +ELR +
Sbjct: 862 KFRE-------------KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908

Query: 760 EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPE 819
           E  + EL  ++   +EN S L K +     E + +++E +QQ   ++ EE+    E K  
Sbjct: 909 ERDVEELQLKLTKANENASFLQKSI-----EDMTVKAEQSQQEAAKKHEEEKKELERKLS 963

Query: 820 DIQMITELKAMLTERDQ 836
           D++     K M T  +Q
Sbjct: 964 DLE-----KKMETSHNQ 975


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  150 bits (379), Expect = 6e-36
 Identities = 209/933 (22%), Positives = 403/933 (43%), Gaps = 129/933 (13%)

Query: 18   DMQLCAEAQHVQ-RIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRR 76
            + +LCAEA+ ++ R+    +E+EEI    E +        V+ E+++   L+  +   ++
Sbjct: 892  ETELCAEAEELRARLTAKKQELEEICHDLEAR--------VEEEEERCQHLQAEKKKMQQ 943

Query: 77   EIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQ 136
             IQEL +  ++  ++  K Q     L ++  E+  K LEE ++    ++ED   KL K +
Sbjct: 944  NIQELEEQLEEEESARQKLQ-----LEKVTTEAKLKKLEEEQI----ILEDQNCKLAKEK 994

Query: 137  SFYE---RELDTLKRSQLFTAESLQASKEK--------EADLRKEFQGQEAILRKTIGKL 185
               E    E  T    +   ++SL   K K        E  LR+E + Q   L KT  KL
Sbjct: 995  KLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE-EKQRQELEKTRRKL 1053

Query: 186  KTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESEL 245
            + +   + D+   L  +  +L+  LA  E  +Q    ++++    +   L K +E+ES++
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113

Query: 246  A----------AARERLQQQASDL-----VLKASHIGMLQATQMTQEVTIKDLESEKSRV 290
            +          A+R + ++Q  DL      LK      L +T   QE+  K     +  V
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK----REQEV 1169

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQ--EYYERELKNLQSRL 348
            N     LEEE     ++ Q + ++  Q + EL +++ + KR +   E  ++ L+N +  L
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL 1229

Query: 349  EEEVTQLNEAHSKT----------LEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE---- 394
              EV  L +    +          L+EL  K +   E V +       KLQ++L+     
Sbjct: 1230 ANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG-ERVRTELADKVTKLQVELDNVTGL 1288

Query: 395  --QHNKDKLNLEEDKNQLQQELENLKEVLED----------KLNTANQEIGHLQDMVRKS 442
              Q +     L +D + L+ +L++ +E+L++          KL     E    ++ + + 
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348

Query: 443  EQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 502
            E+   + E  IA+L      ++ +++ +   L+  ++    ++ +LE   Q+HEE +AA 
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY 1408

Query: 503  KEEEKLK--VDKMAHDLEIKWTENLRQECSKLREELRL-QHEEDKKSAMSQLLQLKDREK 559
             + EK K  + +   DL +      +  C+  +++ +  Q   ++K+  ++  + +DR +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468

Query: 560  NAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQ 619
              AR+   K +         L + LE  + Q +  L++L  QF  E + L    +++ + 
Sbjct: 1469 AEAREKETKALS--------LARALEEAMEQ-KAELERLNKQFRTEMEDLMSSKDDVGKS 1519

Query: 620  HQQRHKSLK--EAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRI 677
              +  KS +  E  V   +T  EE E E +A E+  + +    LQ++K      ++G   
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATED-AKLRLEVNLQAMKAQFERDLQGRDE 1578

Query: 678  EMEQ-------ELQTLRFELEDEGK--AMLASLRSELN---HQHAAAIDLLRHNHHQ--- 722
            + E+       +++ +  ELEDE K  +M  + R +L        A ID    N  +   
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638

Query: 723  ---ELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEV--------Q 771
               +L A   +  R +D +R   +E + +  + +++L+  E  + +L +E+        Q
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698

Query: 772  HLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAML 831
               E      +     GK  L +  +   + R+ ++EE+    +   E I     LK   
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN--DRLKKAN 1756

Query: 832  TERDQIIKKL--------IEDNKFYQLELVNRE 856
             + DQI   L          +N   QLE  N+E
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQNKE 1789



 Score =  108 bits (271), Expect = 2e-23
 Identities = 166/753 (22%), Positives = 296/753 (39%), Gaps = 148/753 (19%)

Query: 222  KQLDDAKEGEMALLSKHKEV----ESELAAARERLQQQASDLVLKASHIGMLQATQMTQE 277
            K L      E  +++K +E+    E +LAA     + +     L A  + + +  Q   E
Sbjct: 835  KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894

Query: 278  VTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKK------------ 325
            +   + E  ++R+  +  +LEE    L ++ +  +EE++ Q L+ EKK            
Sbjct: 895  LCA-EAEELRARLTAKKQELEEICHDLEARVE--EEEERCQHLQAEKKKMQQNIQELEEQ 951

Query: 326  ----------------VNEAKRTQQEYYE-----------RELKNLQSRLEEEVTQLNEA 358
                              EAK  + E  +           +E K L+ R+ E  T L E 
Sbjct: 952  LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011

Query: 359  H--SKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK---DKLNLEEDKNQLQQE 413
               SK+L +L  KH   I  +     R++K+ Q +LE+   K   D  +L +   +LQ +
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQ-ELEKTRRKLEGDSTDLSDQIAELQAQ 1070

Query: 414  LENLKEVL---EDKLNTA---------------------NQEIGHLQDMVRKSEQGLGSA 449
            +  LK  L   E++L  A                       +I  LQ+ +         A
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130

Query: 450  EGLIASLQDSQERLQNELDLTKDS------LKETKDALLNV-EGELEQERQQHEETIAAM 502
            E     L +  E L+ EL+ T DS      L+  ++  +N+ +  LE+E + HE  I  M
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190

Query: 503  KEEEKLKVDKMAHDLE---------IKWTENLRQECSKLREELRL--------QHEEDKK 545
            +++    V+++A  LE          K  + L  E  +L  E+++        +H+  K 
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV 1250

Query: 546  SAMSQLLQLKDREKNAARDSWQKKVE----DLLNQISLLKQN-------------LEIQL 588
             A  Q LQ+K  E    R     KV     +L N   LL Q+             LE QL
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL 1310

Query: 589  SQSQTSLQQ-------LQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEE 641
              +Q  LQ+       L  +  Q         E+LEE+ + +H   K+   L  Q  + +
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370

Query: 642  KEKEQRA----LENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAM 697
            K+ E           +++K   +L+ L   H E +  +  ++E+    L+ EL+D     
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD-KLEKTKTRLQQELDD----- 1424

Query: 698  LASLRSELNHQHAAAIDLLRHNH-------HQELAAAKMELERSIDISRRQSKEHICRIT 750
               L  +L+HQ  +A +L +           ++  +AK   ER  D +  +++E   +  
Sbjct: 1425 ---LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER--DRAEAEAREKETKAL 1479

Query: 751  DLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEK 810
             L   L       +EL++  +     +  L    +  GK +  +  E +++   +++EE 
Sbjct: 1480 SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL--EKSKRALEQQVEEM 1537

Query: 811  YLMRESKPEDIQMITELKAMLTERDQIIKKLIE 843
                E   +++Q   + K  L    Q +K   E
Sbjct: 1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570



 Score =  108 bits (269), Expect = 3e-23
 Identities = 173/843 (20%), Positives = 348/843 (41%), Gaps = 159/843 (18%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            K  AL +    + ++ ++Q   E++   R      + E+ +R   E+L +  + +++   
Sbjct: 1099 KNMALKKIRELESQISELQEDLESERASR-----NKAEKQKRDLGEELEAL-KTELEDTL 1152

Query: 62   DKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 121
            D   A ++L++   +E+  L K+ ++ + +     ++  + H   VE L + LE+ +  +
Sbjct: 1153 DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK 1212

Query: 122  KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRK---EFQGQEAIL 178
              L E  +  L   +     E+  L + +    +S    K+ EA L++   +F   E + 
Sbjct: 1213 ANL-EKAKQTLENERGELANEVKVLLQGK---GDSEHKRKKVEAQLQELQVKFNEGERVR 1268

Query: 179  RKTIGKLKTELQMVQDEAGSLLD----KCQKLQTALAIAENNVQVLQKQLDDAKEGEMAL 234
             +   K+ T+LQ+  D    LL     K  KL    +  E+ +Q  Q+ L +    +++L
Sbjct: 1269 TELADKV-TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327

Query: 235  LSKHKEVESELAAARERLQQ-----------------QASDLVLKASH-IGMLQATQMTQ 276
             +K K+VE E  + RE+L++                 Q +D+  K    +G L+  +  +
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387

Query: 277  EVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDE------EQKQQILELEKK----- 325
                KDLE    R  E+++  ++         Q LD+       Q+Q    LEKK     
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD 1447

Query: 326  -------------VNEAKRTQQEYYERELK--NLQSRLEE------EVTQLNEAHSKTLE 364
                           E  R + E  E+E K  +L   LEE      E+ +LN+     +E
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507

Query: 365  ELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK-----DKLNLEED------------K 407
            +L        ++VH    + K+ L+  +EE   +     D+L   ED            K
Sbjct: 1508 DLMSSKDDVGKSVHELE-KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566

Query: 408  NQLQQELENLKEVLEDKLNTANQEI----GHLQDMVRKSEQGLGSAEGLIASLQDSQERL 463
             Q +++L+   E  E+K     +++      L+D  ++    + + + L   L+D +  +
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626

Query: 464  QNELDLTKDSLKETKDALLNVEG---ELEQERQQHEETIAAMKEEEKLKVDKMAHDL--- 517
             +      +++K+ +     ++    EL+  R   EE +A  KE EK K+  M  ++   
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK-KLKSMEAEMIQL 1685

Query: 518  --EIKWTENLRQECSKLREEL--------------------------RLQHEEDKKSAMS 549
              E+   E  +++  + R+EL                          +L+ E +++   +
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745

Query: 550  QLLQLKDREKNAARD----------SWQKKVEDLLNQISLLKQNLEIQL--------SQS 591
            +L+  + ++ N   D          S  +K E+   Q+    + L+++L        S+ 
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY 1805

Query: 592  QTSLQQLQAQFTQERQRLTQELEELE---EQHQQRHKSLKEAHVLAFQTMEEEKEKEQRA 648
            + S+  L+A+  Q  ++L  E +E +   +Q ++  K LK+   +  Q  +E +  EQ  
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKD---VLLQVDDERRNAEQ-- 1860

Query: 649  LENHLQQKHSAELQSLKDAHRESME------GFRIEMEQELQTLRFELEDEGKAMLASLR 702
                   K S  L+ LK    E+ E        R ++++EL+    E  D     ++SL+
Sbjct: 1861 -YKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT-ETADAMNREVSSLK 1918

Query: 703  SEL 705
            ++L
Sbjct: 1919 NKL 1921



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 78/314 (24%), Positives = 145/314 (46%), Gaps = 40/314 (12%)

Query: 530  SKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLS 589
            +K++  L++  +E++  A  + L +K REK  A ++   ++E L +Q+   K  L+ QL 
Sbjct: 832  TKVKPLLQVSRQEEEMMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL- 889

Query: 590  QSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQ--R 647
            Q++T   +L A+  + R RLT + +ELEE        ++E          E+K+ +Q  +
Sbjct: 890  QAET---ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946

Query: 648  ALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFE---LEDEGKAMLASLRSE 704
             LE  L+++ SA         R+ ++  ++  E +L+ L  E   LED+    LA  +  
Sbjct: 947  ELEEQLEEEESA---------RQKLQLEKVTTEAKLKKLEEEQIILEDQ-NCKLAKEKKL 996

Query: 705  LNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHIS 764
            L  + A     L     +  + AK++             +H   ITDL+E LR  E    
Sbjct: 997  LEDRIAEFTTNLTEEEEKSKSLAKLK------------NKHEAMITDLEERLRREEKQRQ 1044

Query: 765  ELDKEVQHLHENISALTKELEFKGKEILRI-----RSESNQQIRLEEMEEKYLMRESKPE 819
            EL+K  + L  + + L+ ++     +I  +     + E   Q  L  +EE+      K  
Sbjct: 1045 ELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE---AAQKNM 1101

Query: 820  DIQMITELKAMLTE 833
             ++ I EL++ ++E
Sbjct: 1102 ALKKIRELESQISE 1115


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  145 bits (366), Expect = 2e-34
 Identities = 212/896 (23%), Positives = 397/896 (44%), Gaps = 135/896 (15%)

Query: 3    QQALTEFEAYKHRVE-DMQLCAEAQHVQ-RIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
            QQ L E      +++ + +L AEA+ ++ R+    +E+EEI    E +        V+ E
Sbjct: 883  QQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESR--------VEEE 934

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            +++   L++ +   +  IQ+L     +      +G  +  +L ++  E+  K +EE  L 
Sbjct: 935  EERNQILQNEKKKMQAHIQDL-----EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEIL- 988

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180
               L+ED   K  K +   E  +          +  L   +EK  +L K    QE ++  
Sbjct: 989  ---LLEDQNSKFIKEKKLMEDRIAEC-------SSQLAEEEEKAKNLAKIRNKQEVMISD 1038

Query: 181  TIGKLKTELQMVQDEAGSLLDKCQ-KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 239
               +LK E +  Q+     L+K + KL       ++ +  LQ Q+D+ K   + L  K +
Sbjct: 1039 LEERLKKEEKTRQE-----LEKAKRKLDGETTDLQDQIAELQAQIDELK---LQLAKKEE 1090

Query: 240  EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ--- 296
            E++  LA   +       + + K + + +++  Q       +D ESEK+  N+   Q   
Sbjct: 1091 ELQGALARGDD-------ETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143

Query: 297  LEEERAFLRSKTQ-SLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQL 355
            L EE   L+++ + +LD    QQ L  ++             E+E+  L+  LEEE    
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKR-------------EQEVAELKKALEEETKN- 1189

Query: 356  NEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELE 415
               H   ++++  +H  A+E + S  +   K+ + +LE    K+K  LE D  +L  E++
Sbjct: 1190 ---HEAQIQDMRQRHATALEEL-SEQLEQAKRFKANLE----KNKQGLETDNKELACEVK 1241

Query: 416  NLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLK 475
             L++V  +  +   +    +Q++  K  +G    + L   L +   +LQNELD     L+
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEG----DRLRVELAEKASKLQNELDNVSTLLE 1297

Query: 476  ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREE 535
            E +   +    +      Q ++T   ++EE + K++  +   +++  +N  QE  +  EE
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357

Query: 536  LRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSL 595
             R   E+   +  SQL   K            KKV+D L  I  L++  +  L  ++   
Sbjct: 1358 ARKNLEKQVLALQSQLADTK------------KKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 596  QQLQA------QFTQERQRLTQELEEL--EEQHQQRHKSLKEAHVLAF-QTMEEEKE--- 643
            Q+L+       +  + + RL QEL++L  +  HQ++  S  E     F Q + EEK    
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 644  ---KEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLAS 700
               +E+   E   ++K +  L SL  A  E++E  + E E++ + LR ++ED     L S
Sbjct: 1466 RYAEERDRAEAEAREKETKAL-SLARALEEALEA-KEEFERQNKQLRADMED-----LMS 1518

Query: 701  LRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHRE 760
             + ++             N H EL  +K  LE+ ++  R Q +E       L++EL+  E
Sbjct: 1519 SKDDVG-----------KNVH-ELEKSKRALEQQVEEMRTQLEE-------LEDELQATE 1559

Query: 761  HHISELDKEVQHLHENI--SALTKELEFKGKEILRIRSESNQQIRLE-EMEEKYLMRESK 817
                 L+  +Q +         T++ + + K+ L I+     +  LE E +++ L   SK
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619

Query: 818  PE---DIQ-MITELKAMLTERDQIIK---KLIEDNKFYQLELVNRETNFNKVFNSS 866
             +   D++ +  +++A    RD++IK   KL    K YQ EL     + +++F  S
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS 1675



 Score =  121 bits (303), Expect = 4e-27
 Identities = 180/830 (21%), Positives = 361/830 (43%), Gaps = 118/830 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            K+    E EA K  +ED      AQ   R     +EV E+++  EE+            K
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELR-TKREQEVAELKKALEEET-----------K 1188

Query: 62   DKRLALEDLQAAHRREIQEL---LKSQQDHSASVNKGQEKAEELHR---MEVESLNKMLE 115
            +    ++D++  H   ++EL   L+  +   A++ K ++  E  ++    EV+ L ++  
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248

Query: 116  ELRLERKKL---IEDYEGKLNKAQ----------SFYERELDTLKRSQLFTAESLQASKE 162
            E   +RKKL   +++   K+++            S  + ELD +  + L  AE       
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS-TLLEEAEKKGIKFA 1307

Query: 163  KEA-DLRKEFQGQEAILRKTIGK---LKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ 218
            K+A  L  + Q  + +L++   +   L + ++ +++E  SL ++ ++ + A    E  V 
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367

Query: 219  VLQKQLDDAKE------GEMALLSKHKE------------------VESELAAARERLQQ 254
             LQ QL D K+      G +  L + K+                     +L   + RLQQ
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427

Query: 255  QASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEE 314
            +  DL +   H   + +    ++     L +E+  ++ R ++ E +RA   ++      E
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE-ERDRAEAEAR------E 1480

Query: 315  QKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAI 374
            ++ + L L + + EA   ++E+ ER+ K L++ +E+ ++  ++   K + EL  K   A+
Sbjct: 1481 KETKALSLARALEEALEAKEEF-ERQNKQLRADMEDLMSSKDDV-GKNVHELE-KSKRAL 1537

Query: 375  EAVHSNAIRDKKKLQMDL---EEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQE 431
            E          ++L+ +L   E+   + ++N++  K Q +++L+   E  E+K     ++
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597

Query: 432  I----GHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ---NELDLTKDSLKETKDALLNV 484
            +      L+D  ++    + S + +   L+D + +++      D     L++ +  + + 
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657

Query: 485  EGELEQERQQHEETIAAMKEEEK----LKVDKMAHDLEIKWTENLRQECSKLREEL--RL 538
            + ELE+ R   +E  A  KE EK    L+ + +    E+  +E  R+   + R+EL   +
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717

Query: 539  QHEEDKKSAM--------SQLLQLKDR--EKNAARDSWQKKVEDLLNQISLLKQNLEIQL 588
             +    KSA+        +++ QL++   E+ +  +    +      Q+  L   L  + 
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER 1777

Query: 589  SQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEE--EKEKEQ 646
            S +Q S    + Q  ++ + L  +L+ELE   + + K+   A       +EE  E+E ++
Sbjct: 1778 SAAQKS-DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836

Query: 647  RALENHLQQKHSAELQSL----------KDAHRESMEGFRIEMEQELQTLRFELEDEGKA 696
            RA  N L ++   +L+ +           D ++E ME     M+Q  + L  E E+E   
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLE-EAEEEATR 1895

Query: 697  MLAS---LRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSK 743
              AS   L+ EL+    A   L R     E++  K  L R   IS   S+
Sbjct: 1896 ANASRRKLQRELDDATEANEGLSR-----EVSTLKNRLRRGGPISFSSSR 1940



 Score =  114 bits (284), Expect = 6e-25
 Identities = 182/859 (21%), Positives = 350/859 (40%), Gaps = 164/859 (19%)

Query: 136  QSFYERELDTLKRSQLFTAESLQASKEKEADLR-----KEFQGQEAILRKTIGKLKTELQ 190
            + +  R+    K+ QL   + LQ +      LR     + F   + +L+ T  + + ELQ
Sbjct: 798  RGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVT--RQEEELQ 855

Query: 191  MVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARE 250
               +E   + +K  K++  L   E   Q L +        E  +L++  + E+EL A  E
Sbjct: 856  AKDEELLKVKEKQTKVEGELEEMERKHQQLLE--------EKNILAEQLQAETELFAEAE 907

Query: 251  RLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS 310
             ++ +             L A +   E  + DLES      ER   L+ E+  +++  Q 
Sbjct: 908  EMRAR-------------LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954

Query: 311  L-----DEEQKQQILELEKKVNEAK-----------RTQQEYYERELKNLQSRLEEEVTQ 354
            L     +EE  +Q L+LEK   EAK             Q   + +E K ++ R+ E  +Q
Sbjct: 955  LEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014

Query: 355  L--NEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNK---DKLNLEEDKNQ 409
            L   E  +K L ++  K  + I  +    ++ ++K + +LE+   K   +  +L++   +
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEER-LKKEEKTRQELEKAKRKLDGETTDLQDQIAE 1073

Query: 410  LQQELENLKEVLEDK-----------------LNTANQEIGHLQDMVRKSEQGLGSAEGL 452
            LQ +++ LK  L  K                  N A + +  LQ  + + ++   S +  
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133

Query: 453  IASLQDSQERLQNELDLTKDSLKETKDA--------------LLNVEGELEQERQQHEET 498
                +  +  L  EL+  K  L++T D               +  ++  LE+E + HE  
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193

Query: 499  IAAMKEEEKLKVDKMAHDLE---------IKWTENLRQECSKLREELRL--------QHE 541
            I  M++     +++++  LE          K  + L  +  +L  E+++        +H+
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK 1253

Query: 542  EDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQI----SLLKQ-------------NL 584
              K  A  Q L  K  E +  R    +K   L N++    +LL++             +L
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313

Query: 585  EIQLSQSQTSLQQLQAQ---FTQERQRLTQELEELEEQHQQRHKSLK--EAHVLAFQ--- 636
            E QL  +Q  LQ+   Q    +   ++L +E   L+EQ ++  ++ K  E  VLA Q   
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373

Query: 637  ---------------TMEEEKE---KEQRALENHLQQKHSA--ELQSLKDAHRESMEGFR 676
                           ++EE K+   K+  AL   L++K  A  +L+  K+  ++ ++   
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433

Query: 677  IEMEQELQTL--------RF-ELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAA 727
            ++++ + Q          +F +L  E K++ A    E +   A A +  +      LA A
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE--KETKALSLARA 1491

Query: 728  KMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL--- 784
              E   + +   RQ+K+    + DL         ++ EL+K  + L + +  +  +L   
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551

Query: 785  --EFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPED-----IQMITELKAMLTERDQI 837
              E +  E  ++R E N Q    + E     R+ + E+     I+ + EL+A L +  + 
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611

Query: 838  IKKLIEDNKFYQLELVNRE 856
                +   K  +++L + E
Sbjct: 1612 RALAVASKKKMEIDLKDLE 1630



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 120/586 (20%), Positives = 252/586 (43%), Gaps = 65/586 (11%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAA--HRREIQELLKSQQ---DHSA 90
            ++ E + ++ EEK  ++ +L+ + +   +  L+DL     H+R++   L+ +Q   D   
Sbjct: 1399 KDAEALSQRLEEKALAYDKLE-KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457

Query: 91   SVNKG--QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKR 148
            +  K      AEE  R E E+  K  + L L R  L E  E K       +ER+   L+ 
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARA-LEEALEAKEE-----FERQNKQLRA 1511

Query: 149  SQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQT 208
                  E L +SK+       E +  +  L + + +++T+L+ ++DE  +  D   +L+ 
Sbjct: 1512 DM----EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567

Query: 209  AL-AIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARER-----LQQQASDLVLK 262
             + A+     + LQ + +  +E +  L+ + +E+E+EL   R++       ++  ++ LK
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627

Query: 263  ASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSK-TQSLDEEQKQQILE 321
                  ++A    ++  IK L   ++++ +   +LEE RA       QS + E+K + LE
Sbjct: 1628 DLE-AQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLE 1686

Query: 322  LEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEE--------LAWKHHMA 373
             E    + +    E   R  +  +  L +E+T      S  L+E           +  + 
Sbjct: 1687 AEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE 1746

Query: 374  IEAVHSNAIRD---KKKLQMDL-----------EEQHNKDKLNLEEDKNQLQQELENLKE 419
             E  +   + D   K  LQ+D             ++ +  +  LE    +L+ +L+ L+ 
Sbjct: 1747 EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG 1806

Query: 420  VLEDK----LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLK 475
             ++ K    ++    +IG L++ + +  +   +A  L+   +   + +  +++  +    
Sbjct: 1807 AVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHAD 1866

Query: 476  ETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD----KMAHDLE--IKWTENLRQEC 529
            + K+ +      ++Q ++Q EE      EEE  + +    K+  +L+   +  E L +E 
Sbjct: 1867 QYKEQMEKANARMKQLKRQLEEA-----EEEATRANASRRKLQRELDDATEANEGLSREV 1921

Query: 530  SKLREELRLQHEEDKKSAMS--QLLQLKDREKNAARDSWQKKVEDL 573
            S L+  LR        S+ S  + L L+      + D  + K  D+
Sbjct: 1922 STLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDV 1967


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  145 bits (366), Expect = 2e-34
 Identities = 209/919 (22%), Positives = 400/919 (43%), Gaps = 140/919 (15%)

Query: 26   QHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQ 85
            Q +QR+  M R +   R K+ E + ++  LQ +                ++++Q +L   
Sbjct: 138  QLIQRLRRMERSLSSYRGKYSELVTAYQMLQRE----------------KKKLQGILSQS 181

Query: 86   QDHSASVNKGQEKAEELHRMEVESLNKMLEEL--RLERKKLIEDYEGKLNKAQSFYEREL 143
            QD S  + +  E  EEL +M+ ++   + EE    LE K   + Y   L    S  ++ L
Sbjct: 182  QDKS--LRRIAELREEL-QMDQQAKKHLQEEFDASLEEK---DQYISVLQTQVSLLKQRL 235

Query: 144  -------DTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEA 196
                   D LK       ++   +KE+      E  G+  +   T  K    LQ      
Sbjct: 236  RNGPMNVDVLKPLPQLEPQAEVFTKEENP----ESDGEPVVEDGTSVKTLETLQQRVKRQ 291

Query: 197  GSLLDKCQ------KLQTALAIAENNVQVLQKQLDDA-----KEGEMALLSKHKEVESEL 245
             +LL +C+      K Q  L  +E   + LQ+QLD+      K  ++ +  K K + ++L
Sbjct: 292  ENLLKRCKETIQSHKEQCTLLTSEK--EALQEQLDERLQELEKIKDLHMAEKTKLI-TQL 348

Query: 246  AAARERLQQQASD--LVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAF 303
              A+  ++Q   D  +V+  +   M +  +M +E    ++   +SR+ +  +Q EE R  
Sbjct: 349  RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE----EIAQLRSRIKQMTTQGEELRE- 403

Query: 304  LRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTL 363
             + K++    E+ ++ L   +K  EA+R  +   + ++K ++   EEE   L +  S+  
Sbjct: 404  QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK 463

Query: 364  EELAWKHHMAIEAVHSNAIRDKKKLQ------MDLEEQHNKDKLNLEEDKNQLQQEL--- 414
            +E+       ++ +  ++     KLQ      +  +EQ    KL   E + Q Q ++   
Sbjct: 464  QEV-------VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALE 516

Query: 415  ENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQER-----LQNELDL 469
            ++  E L+       QE   L+++  + +  L  +E  +  LQ   E      L+ E  L
Sbjct: 517  KSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSL 576

Query: 470  TKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLR--- 526
             K SL+E K+   ++   LE E+ +H + I  M E+ K +++ + H  +  WTE L+   
Sbjct: 577  EK-SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK 635

Query: 527  ----QECSKLREELRLQHE---EDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQIS- 578
                 E  KLRE+   + E   +DK+      ++  + +     D  Q ++E L +++S 
Sbjct: 636  QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSE 695

Query: 579  ------LLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQH----QQRHKSLK 628
                   L++ L +   Q+    Q+L+A+  +++    Q+++ + ++H    Q+  K+LK
Sbjct: 696  VLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755

Query: 629  -------------EAHVLAFQTMEEEKEKEQRALENHLQQKHSAEL---QSLKDAHRESM 672
                         + H+   Q   E  E + +  E  LQQ  SA+L   QS + A  E  
Sbjct: 756  DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA-SAKLDVFQSYQSATHEQT 814

Query: 673  EGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELE 732
            + +  ++ Q LQ    +LE E + +L         +  A ++  + +   EL A K++++
Sbjct: 815  KAYEEQLAQ-LQQKLLDLETE-RILLT--------KQVAEVEAQKKDVCTELDAHKIQVQ 864

Query: 733  ---RSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGK 789
               + ++    + ++ +  +T + E      +   E  K++    EN+    +E + K  
Sbjct: 865  DLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI 924

Query: 790  EILRIR---SESNQQIRLEEMEEKYLMRESKPEDI-----QMITELKAMLTERDQIIKKL 841
            EIL  +    E +  I  EE E K+  +E K E +     +M   LK  L +++  +KK 
Sbjct: 925  EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984

Query: 842  IEDNKFYQLELVNRETNFN 860
            +E+     LEL  +E  FN
Sbjct: 985  LENT---ALELSQKEKQFN 1000



 Score =  142 bits (357), Expect = 2e-33
 Identities = 217/996 (21%), Positives = 423/996 (42%), Gaps = 191/996 (19%)

Query: 15   RVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQ-FEKDKRLALEDLQAA 73
            + E+ +   +A+  ++I T+ +  EE R   +++L    Q  V   +K     +  LQ  
Sbjct: 425  KTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL 484

Query: 74   HRREI----QELLKS--------QQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 121
            H +E+    QEL K         Q+    ++ K Q +  ++ + + +  +  LEEL L++
Sbjct: 485  HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK 544

Query: 122  KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKT 181
            K ++ + E KL   Q   E     +   +    +SLQ +K +  DL    + ++    K 
Sbjct: 545  KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKE 604

Query: 182  IG----KLKTEL-------------------QMVQDEAGSLLDKCQKLQTALA------- 211
            I     K KTEL                   Q  Q E   L +KC++ +  L        
Sbjct: 605  ITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIF 664

Query: 212  ---IAENNVQVLQKQLDDAKEGEMALLS---------KHKEVESELAAARERLQQQASDL 259
               I E N + L+K   D K+ E+  LS         +HK +E EL+  +++  +   +L
Sbjct: 665  QAHIEEMNEKTLEKL--DVKQTELESLSSELSEVLKARHK-LEEELSVLKDQTDKMKQEL 721

Query: 260  VLKAS-----HIGMLQATQMTQEVTIKDLESE-KSRVN-------ERLSQLEEERAFLRS 306
              K       H   + +     EV+I+  E   K ++N       ER   L+E +A + +
Sbjct: 722  EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVEN 781

Query: 307  -----KTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSK 361
                 K    + +Q    L++ +    A   Q + YE +L  LQ +L +  T+      +
Sbjct: 782  LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ 841

Query: 362  TLEELAWKHHMAIEAVHSNAIRDKKKLQM-DLEEQHNKDKLNLEEDKNQLQQELENLKEV 420
              E  A K  +  E        D  K+Q+ DL +Q       LE+  ++++Q++++L +V
Sbjct: 842  VAEVEAQKKDVCTEL-------DAHKIQVQDLMQQ-------LEKQNSEMEQKVKSLTQV 887

Query: 421  LEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQER----LQNELDLTKDSL-- 474
             E KL   N+E         +++Q L   E +I  +++ Q++    L  +L   +DS+  
Sbjct: 888  YESKLEDGNKE-------QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHI 940

Query: 475  --KETKDALLNVEGELEQERQQHEETIAAMKE---EEKLKVDKMAHDLEIKWTENLRQEC 529
              +E +    N E ++E+ +Q+ +E    +K+   +++ K+ K   +  ++ ++  +Q  
Sbjct: 941  LNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000

Query: 530  SKLREELRLQH----------EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISL 579
            +K+ E  +             E ++K  +  L ++  RE N     W+KK   L  Q   
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK---LNQQAEE 1057

Query: 580  LKQNLEIQLSQSQTSLQQLQAQ---FTQERQRLTQE--------------LEELEEQHQQ 622
            L++  EIQL + +  + +L+ +   F  E++ + +E              L EL+EQ +Q
Sbjct: 1058 LQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQ 1117

Query: 623  R-------------------------HKSLKEAHVLAFQTME-----EEKEKEQRALENH 652
            +                         +KSLKE   L  Q +E     EE +++   L + 
Sbjct: 1118 KSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177

Query: 653  LQQKHSAELQSLKDAH---RESMEGFRIEMEQELQTLRFELE---DEGKAMLASLRSEL- 705
            L+     E QSLK +H    +S+E   +E ++  + L  +L+    + +A+L +  +EL 
Sbjct: 1178 LKTT-DEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI 1236

Query: 706  ---NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEEL----RH 758
               + +  A +  + H  H+     +  L ++  +S  +++  + ++T+ Q  L    + 
Sbjct: 1237 NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ--LRQLTEEQNTLNISFQQ 1294

Query: 759  REHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKP 818
              H + E + +++ +  +I +L  E     KE L+    + QQ   E+      +++   
Sbjct: 1295 ATHQLEEKENQIKSMKADIESLVTE-----KEALQKEGGNQQQAASEKESCITQLKKELS 1349

Query: 819  EDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVN 854
            E+I  +T +K  L E+   I  L +      ++L N
Sbjct: 1350 ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385



 Score =  137 bits (346), Expect = 4e-32
 Identities = 206/991 (20%), Positives = 419/991 (42%), Gaps = 144/991 (14%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 61
            K+   TE +A+K +V+D+    E Q+ +    M ++V+ + + +E KL    + Q Q ++
Sbjct: 849  KKDVCTELDAHKIQVQDLMQQLEKQNSE----MEQKVKSLTQVYESKLEDGNKEQEQTKQ 904

Query: 62   ---DKRLALEDLQAAHRREIQEL---LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLE 115
               +K   +  ++   ++EI+ L   L +++D    +N+  E   +    ++E + +  +
Sbjct: 905  ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964

Query: 116  ELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQE 175
            E++   KK + D E KL K        L+  ++ + F A+ L+ ++   A +       E
Sbjct: 965  EMQETLKKKLLDQEAKLKK--ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE 1022

Query: 176  AILRKTIGKLKTELQMVQDEAGSLLDK--CQKLQTALAIAENNVQVLQKQLDDAKEGEMA 233
               ++ I  L    +   ++  S+ +K   Q+ +    I E  +Q  ++++ + K+  + 
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL 1082

Query: 234  LLSKHKEVESELAAARER-------LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESE 286
               + +E+  E+   +E        L +    L  K++H+  L   +   +  ++ LE +
Sbjct: 1083 FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD 1142

Query: 287  KSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEY------YERE 340
             ++  +  + L+E+   L+     L EE K+++ EL  K+   K T +E+      +E+ 
Sbjct: 1143 LNKSLKENTFLQEQLVELK----MLAEEDKRKVSELTSKL---KTTDEEFQSLKSSHEKS 1195

Query: 341  LKNLQSR-------LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE 393
             K+L+ +        EE   QL+    KT   L  K +   E ++ ++ +    L     
Sbjct: 1196 NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTN---ELINISSSKTNAILSRISH 1252

Query: 394  EQHNKDKL-NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGL 452
             QH   K+      K     ELE     L ++ NT N         + + E  + S +  
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD 1312

Query: 453  IASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLK--- 509
            I SL   +E LQ E    + +  E +  +     +L++E  ++   +  MKEE K K   
Sbjct: 1313 IESLVTEKEALQKEGGNQQQAASEKESCIT----QLKKELSENINAVTLMKEELKEKKVE 1368

Query: 510  ---VDKMAHDLEIKWTENLR-QECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARD- 564
               + K   DL ++   ++   E       LR Q++E+K   + Q+  L  +    +++ 
Sbjct: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428

Query: 565  -SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQF---TQERQRLTQELEELEEQH 620
             S  ++V+D  N+ S  K+  + + +Q Q ++++LQ Q    ++E     +++  L+E+ 
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488

Query: 621  QQRHKSL----------------KEAHV---LAFQT---MEEEKEKEQRALE-------- 650
             Q++K                  KE+++   L  QT   ME E    Q+ +E        
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL 1548

Query: 651  -NHLQQK------------HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAM 697
             N+ QQK            H  EL   KD   +  E   + +E ++ +++ ELE + K +
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKEL 1608

Query: 698  -------------LASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKE 744
                         L +L   L  + AA +  L+    Q++AA K +L     +S+ + KE
Sbjct: 1609 EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQL-----LSQMEEKE 1663

Query: 745  HICRITDLQEELRHREHHISELDKEVQHLHENISAL---TKELEFKGKEILRIRSESNQQ 801
                    ++  +  E H+SEL+ ++Q     +  L    K +E    E L +   +   
Sbjct: 1664 --------EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNV 1715

Query: 802  IRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK-----------FYQL 850
                E EE       +    + I+ L+  LTE++++++++ ++ +            YQ 
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE 1775

Query: 851  ELVNRETNFNKVFNSSPTVGVINPLAKQKKK 881
             L+  E    K       +G +    ++K K
Sbjct: 1776 RLIKLEHAEAKQHEDQSMIGHLQEELEEKNK 1806



 Score =  115 bits (288), Expect = 2e-25
 Identities = 176/818 (21%), Positives = 358/818 (43%), Gaps = 123/818 (15%)

Query: 50  RSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVES 109
           R  G  Q  F +  +L +  +++  R  I+E L       + V       E L+R++++S
Sbjct: 53  RESGDTQ-SFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSR--ESLNRLDLDS 109

Query: 110 LNKMLE---ELRLERKKLIEDYEGKLNKAQSFY-----ERELDTL--KRSQLFTA-ESLQ 158
                +   ++  E + L+ + +  LNK Q        ER L +   K S+L TA + LQ
Sbjct: 110 STASFDPPSDMDSEAEDLVGNSDS-LNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQ 168

Query: 159 ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDK----CQKLQTALAIAE 214
             K+K   +    Q Q+  LR+ I +L+ ELQM Q     L ++     ++    +++ +
Sbjct: 169 REKKKLQGILS--QSQDKSLRR-IAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ 225

Query: 215 NNVQVLQKQLDDAKEGEMALLSKHK-EVESELAAARERLQQQASDLVLKASHIGMLQATQ 273
             V +L+++L +       L    + E ++E+    E  +     +V   + +  L+  Q
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQ 285

Query: 274 MTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEK--KVNEAKR 331
                 +K  E+   R  E +   +E+   L S+ ++L E+  +++ ELEK   ++ A++
Sbjct: 286 QR----VKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEK 341

Query: 332 TQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD 391
           T+     R+ KNL  +LE++   +                          I + K+   +
Sbjct: 342 TKLITQLRDAKNLIEQLEQDKGMV--------------------------IAETKRQMHE 375

Query: 392 LEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 451
             E   ++   L     Q+  + E L+E  E     A +E+          E+ L +A+ 
Sbjct: 376 TLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL----------EKALSTAQ- 424

Query: 452 LIASLQDSQERLQNELDLTKDSLKET-KDALLNVEGELEQERQQHEETIAAMKEEEKLKV 510
                ++++ +L+ E+D    ++++T ++  ++++ EL + +Q+  + +    EE+  K+
Sbjct: 425 ---KTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKL 481

Query: 511 DKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKV 570
            K+ H+ E+   E   QE +K  +    + +E  K A+ +           ++  + K  
Sbjct: 482 QKL-HEKELARKE---QELTKKLQTREREFQEQMKVALEK-----------SQSEYLKIS 526

Query: 571 EDLLNQISLLKQNLEIQ----LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKS 626
           ++   Q SL  + LE+Q    L++S+  L+ LQ +    R R+ +    LE+  Q+    
Sbjct: 527 QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586

Query: 627 LKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAH----RESMEGFRIEMEQE 682
            K+  V     +E EK K  + +   + +KH  EL+SLK        E ++  + + + E
Sbjct: 587 SKDLAV----HLEAEKNKHNKEI-TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTE 641

Query: 683 LQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQS 742
           ++ LR + E E + +L     E+  Q  A I+ +     ++L   + ELE          
Sbjct: 642 MEKLREKCEQEKETLLKD--KEIIFQ--AHIEEMNEKTLEKLDVKQTELE---------- 687

Query: 743 KEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQI 802
                  ++L E L+ R     +L++E+  L +    + +ELE K  E    ++   QQ+
Sbjct: 688 ----SLSSELSEVLKARH----KLEEELSVLKDQTDKMKQELEAKMDE---QKNHHQQQV 736

Query: 803 RLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKK 840
                E +  ++ ++      I +L+ +L ERD+ +K+
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774



 Score =  115 bits (288), Expect = 2e-25
 Identities = 228/1035 (22%), Positives = 441/1035 (42%), Gaps = 198/1035 (19%)

Query: 20   QLCAEAQHVQRIVT----MSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHR 75
            QL  ++ HV  +      +   +E++     + L+    LQ Q  + K LA ED     +
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEED-----K 1168

Query: 76   REIQEL---LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKL 132
            R++ EL   LK+  +   S+    EK+           NK LE+  LE KKL E+   +L
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKS-----------NKSLEDKSLEFKKLSEELAIQL 1217

Query: 133  NKAQSFYERELDTLKRSQLFTAESLQAS---KEKEADLRKEFQGQEAILRKT--IGKLKT 187
            +      E  L+  K ++L    S + +           +  + +EA+L KT  + +L+ 
Sbjct: 1218 DICCKKTEALLEA-KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276

Query: 188  ELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAA 247
            +L+ + +E  +L    Q+    L   EN ++ ++  ++     + AL    KE  ++  A
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEGGNQQQA 1333

Query: 248  ARER---LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQ---LEEER 301
            A E+   + Q   +L    + + +++     ++V I  L  + + +N +L     L E+ 
Sbjct: 1334 ASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKE 1393

Query: 302  AFLRSKTQSLDEEQ------------------KQQILELEK------KVNEAKRTQQEYY 337
            A + S  +  DEE+                  K++I  LE+      K +E K+  Q  +
Sbjct: 1394 AAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1453

Query: 338  ---ERELKNLQSRLE---EEVTQLNEAHSKTLEELAWKHHM------AIEAVHSNAIRDK 385
               +  +K LQ +LE   +E  + +E  +   EEL  ++         +E   S   + +
Sbjct: 1454 TQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE 1513

Query: 386  KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTAN-------QEIGHLQDM 438
              L+ +L+ Q  +  + LE+   Q   E+E+L EVL++     +       Q++ H Q++
Sbjct: 1514 SNLETELKSQTARI-MELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL 1572

Query: 439  -------VRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQE 491
                   V+++E+ + + E  + S++   E  + EL+    S+K  ++ L  +E  LE E
Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632

Query: 492  --------RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEED 543
                    +++ E+ IAA+K++   ++++     +     +L +  +KL+E  R  H  +
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692

Query: 544  KK-----SAMSQLLQLKDREKNAARDSWQKKVED-------LLNQISLLKQNLEIQLSQS 591
            +K     S+ S+ L +    KN A  + Q++ +           +IS+L++NL       
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNL------- 1745

Query: 592  QTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALEN 651
             T  ++L  +  QE++       E+  Q+Q+R   L+ A         E K+ E +++  
Sbjct: 1746 -TEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA---------EAKQHEDQSMIG 1795

Query: 652  HLQQK--HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLAS-LRSELNHQ 708
            HLQ++     +  SL  A     EG +  ++ + Q L    +D  K +    L  ++  Q
Sbjct: 1796 HLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK-QNLENVFDDVQKTLQEKELTCQILEQ 1854

Query: 709  HAAAID--LLR----HNHHQELAAAKMELERSI--------------DISRRQSKEHI-- 746
                +D  L+R    H    E   +K E  +++              + +  +SK H+  
Sbjct: 1855 KIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQ 1914

Query: 747  --------CRITDLQEELRHREHHISELDKEVQHLHENISALTK----ELEFKGKEILRI 794
                     +  DL+ +L   E    +L KE+  L +++  L K    ELE   KE  + 
Sbjct: 1915 PKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQE 1974

Query: 795  RSESNQQIRLEEMEEKY------LMRE------SKPEDIQMITE-------------LKA 829
            R E  +Q   E++E K+      LMRE       K ++++M  +             L++
Sbjct: 1975 REEKIKQ-EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033

Query: 830  MLTERDQIIKKLIEDN-------KFYQLELVNRETNFN-KVFNSSPTVGVINPLAKQKKK 881
               E +Q++KK+ E +       K Y+  L  RE     KV +    +  +    +QK +
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093

Query: 882  NDKSPTNRFVSVPNL 896
             +++P N  V++  L
Sbjct: 2094 QEENPGNDNVTIMEL 2108



 Score =  108 bits (270), Expect = 2e-23
 Identities = 165/813 (20%), Positives = 351/813 (43%), Gaps = 107/813 (13%)

Query: 28   VQRIVTMSRE---VEEIRRKF-EEKLRSFGQLQ-VQFE-----KDKRLALEDLQAAHRRE 77
            +Q  +++S +   +  +R+++ EEK     Q+Q + F+     K+K  ALE +     + 
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF 1442

Query: 78   IQELLKSQQDHSASVNKGQE-------KAEELHRMEVESLNKMLEELRLERKKL------ 124
             +   K+Q   +   N  +E       K++E +  + E +N + EEL  + K+       
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD-EQINLLKEELDQQNKRFDCLKGE 1501

Query: 125  IEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEAD----LRKEFQGQEAILRK 180
            +ED + K+ K +S  E EL + + +++   E     K  E +    + K +  Q+ I  K
Sbjct: 1502 MEDDKSKMEKKESNLETELKS-QTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560

Query: 181  TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 240
               +L  +LQ  Q+      ++ ++ +  +   EN V  ++ +L+  K+    +    K 
Sbjct: 1561 ---ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617

Query: 241  VESELAAARERLQQQAS----------DLVLKASHIGMLQATQMTQEVTIKDLESEKSRV 290
             E EL A  +RL+ +++          +  + A    +L   +  +E   K  ES  S +
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677

Query: 291  NERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEE 350
            N +L + E E   L  K +S++  Q + ++                  R  KN+ +  E+
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLI----------------VPRSAKNVAAYTEQ 1721

Query: 351  EVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQL 410
            E         KT EE        I  +  N + +K+KL   + ++  +   +  E + Q 
Sbjct: 1722 EEADSQGCVQKTYEE-------KISVLQRN-LTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773

Query: 411  QQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLT 470
            Q+ L  L+   E K +     IGHLQ+ + +  +       LI +    +E  +N +   
Sbjct: 1774 QERLIKLEHA-EAKQHEDQSMIGHLQEELEEKNKKYS----LIVAQHVEKEGGKNNI--- 1825

Query: 471  KDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 530
                 + K  L NV  ++++  Q+ E T   ++++ K     +    E+   E   +E +
Sbjct: 1826 -----QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVE--MEELT 1878

Query: 531  KLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQ 590
               E+L+   + D ++  ++LL+    EK+ +     K    LL+ +     +LE +L+ 
Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK----LLSNMEAQHNDLEFKLAG 1934

Query: 591  SQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALE 650
            ++           +E+Q+L +E+  L++  +   K  ++   +  +  ++E+E++ +  +
Sbjct: 1935 AE-----------REKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQ 1983

Query: 651  NHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDE-GKAMLASLRSELNHQH 709
              L+ KH++ L+ L       M  F  ++ Q+ Q L   +++   KA    + +EL   H
Sbjct: 1984 EDLELKHNSTLKQL-------MREFNTQLAQKEQELEMTIKETINKAQ--EVEAELLESH 2034

Query: 710  AAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRH-REHHISELDK 768
                + L     ++    K   +R  +I   + +E   ++ DLQ +L   ++ +  +L++
Sbjct: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQ 2094

Query: 769  EVQHLHENISALTKELEFKGKEILRIRSESNQQ 801
            E    ++N++ +  + +   K  L   S+  +Q
Sbjct: 2095 EENPGNDNVTIMELQTQLAQKTTLISDSKLKEQ 2127



 Score =  105 bits (262), Expect = 2e-22
 Identities = 172/925 (18%), Positives = 395/925 (42%), Gaps = 120/925 (12%)

Query: 2    KQQALTEFEAYKHRVEDM------QLCAEAQHVQRIVTMS-REVEEIRRKFEEKLRSFGQ 54
            K+Q  +  E ++  + D+      +L  +A+ +Q I  +  +E E+   + ++K+  FG 
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGC 1085

Query: 55   LQVQFEKDKRLALED--LQAAHRREIQELLKSQQDHSASVNKGQEKAE-ELHRMEVESLN 111
             + +  K+     E+   Q     E+QE LK +  H  S+ + + K +  L ++EV+ LN
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD-LN 1144

Query: 112  KMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEF 171
            K L+E    +++L+E     L       +R++  L      T E  Q+ K       K  
Sbjct: 1145 KSLKENTFLQEQLVE-----LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL 1199

Query: 172  QGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEG- 230
            + +    +K   +L  +L +   +  +LL+   K    + I+ +    +  ++   +   
Sbjct: 1200 EDKSLEFKKLSEELAIQLDICCKKTEALLEA--KTNELINISSSKTNAILSRISHCQHRT 1257

Query: 231  ---EMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEK 287
               + ALL K   V SEL A   +L ++ + L     +I   QAT   +E     ++S K
Sbjct: 1258 TKVKEALLIKTCTV-SELEAQLRQLTEEQNTL-----NISFQQATHQLEEKE-NQIKSMK 1310

Query: 288  SRVNERLSQLEEERAFLRSKTQSLDEEQK---QQILELEKKVNEAKRTQQEYYERELKNL 344
            + +   +++ E  +    ++ Q+  E++    Q   EL + +N     ++E  E++++  
Sbjct: 1311 ADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEI- 1369

Query: 345  QSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLE 404
             S L +++T LN                 ++  +S ++ +K+     L +Q++++K  L 
Sbjct: 1370 -SSLSKQLTDLN-----------------VQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411

Query: 405  EDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 464
            +    L  +++ L +   +K++   Q    + D   K  +    A+      Q++ + LQ
Sbjct: 1412 DQVQDLSFKVDTLSK---EKISALEQ----VDDWSNKFSEWKKKAQSRFTQHQNTVKELQ 1464

Query: 465  NELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWT-- 522
             +L+L      E  + +  ++ EL+Q+ ++ +  +    E++K K++K   +LE +    
Sbjct: 1465 IQLELKSKEAYEKDEQINLLKEELDQQNKRFD-CLKGEMEDDKSKMEKKESNLETELKSQ 1523

Query: 523  ------------------ENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARD 564
                              E+L +      ++  ++H+E  +  +    +L + + N  ++
Sbjct: 1524 TARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK-LQHFQELGEEKDNRVKE 1582

Query: 565  SWQKKVEDLLNQISLLKQNLEIQL-------------------------SQSQTSLQQLQ 599
            + ++K+  L NQ+  +K  LE +                          S+S   L +L+
Sbjct: 1583 A-EEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641

Query: 600  AQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSA 659
             +  Q+   + ++L    E+ ++++K   E+H+    T  +E+E+E   LE  L+   S+
Sbjct: 1642 RKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS 1701

Query: 660  ELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHN 719
            + ++L      S +      EQE    +  ++   +  ++ L+  L  +           
Sbjct: 1702 QSETL--IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL------- 1752

Query: 720  HHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISA 779
              Q +   K E   S    R Q +E + ++   + +    +  I  L +E++  ++  S 
Sbjct: 1753 --QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810

Query: 780  LTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDI-QMITELKAMLTERDQII 838
            +  +   K      I+++ N +   +++++    +E   + + Q I EL + L  + ++ 
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870

Query: 839  KKLIED--NKFYQLELVNRETNFNK 861
            +  +E+  +K+ +L+ + +    NK
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNK 1895


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  145 bits (365), Expect = 2e-34
 Identities = 205/931 (22%), Positives = 409/931 (43%), Gaps = 177/931 (19%)

Query: 3    QQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKD 62
            Q  L+  E   HR+  ++L  + +  Q++     E+ E+  K++     F QLQ Q E+ 
Sbjct: 350  QSRLSASETSLHRIH-VELSEKGEATQKL---KEELSEVETKYQHLKAEFKQLQQQREEK 405

Query: 63   KRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERK 122
            ++  L+             L+S+      +N+   K  E  R   E+  ++ E+ +L  +
Sbjct: 406  EQHGLQ-------------LQSE------INQLHSKLLETERQLGEAHGRLKEQRQLSSE 446

Query: 123  KLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTI 182
            KL+ D E ++   Q    R  + LK     + E LQ   +K    +++ Q Q+A+ + T 
Sbjct: 447  KLM-DKEQQVADLQLKLSRLEEQLKEKVTNSTE-LQHQLDKT---KQQHQEQQALQQSTT 501

Query: 183  GKLK---TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDD------AKEGEMA 233
             KL+    +L+ V  + G    K Q L+  L  ++ N+ +L+K+ +D      A EGE A
Sbjct: 502  AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561

Query: 234  LLSKHKE----VESELAAARERLQQQASD-----------LVLKASHIGMLQATQMTQEV 278
            +L++ +E    ++ ++    E+L+ Q+             +  + +H+   Q   ++ E 
Sbjct: 562  VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621

Query: 279  TIKDLESEKSRVNERLSQLEEERAFLRSKTQ---SLDEEQKQQILELEKKVNEAKRTQQE 335
            ++ +L S+ +   E++SQL+ +   +++KT+   S +  +  Q  +L+  ++ A+   Q+
Sbjct: 622  SVNELNSQLNESKEKVSQLDIQ---IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678

Query: 336  YYERELKNLQSRLEEEVTQLN---------EAHSK-------TLEELAWKHHMAIEAVHS 379
              ++EL  + ++L++   +L          E+H K       +LE+   +    I+ + +
Sbjct: 679  K-QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737

Query: 380  NAIRDKKKLQMDLEEQHNKDKLN--LEEDKNQLQQELENLKEV----------------- 420
            +++  K   +  L++   + +LN  LE    +L ++LE  KE+                 
Sbjct: 738  DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797

Query: 421  LEDKLNTANQEIGHL-QDMVRKSEQGLGSAEGLIASLQDS----------QERLQNELDL 469
            ++ KL    +E   L QD    S++     E L   +Q +          +E L  EL  
Sbjct: 798  IKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857

Query: 470  TKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQEC 529
             KD L +  D+L N + E E+E Q+ +  I                        +L + C
Sbjct: 858  VKDKLSKVSDSLKNSKSEFEKENQKGKAAIL-----------------------DLEKTC 894

Query: 530  SKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLS 589
             +L+ +L++Q E   K    +L +  ++EK A+            +Q+ L   +++ QL 
Sbjct: 895  KELKHQLQVQMENTLKE-QKELKKSLEKEKEAS------------HQLKLELNSMQEQLI 941

Query: 590  QSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRAL 649
            Q+Q +L+Q +    +E Q+L   + EL++  +Q+ K ++     A Q   +    ++  L
Sbjct: 942  QAQNTLKQNE----KEEQQLQGNINELKQSSEQKKKQIE-----ALQGELKIAVLQKTEL 992

Query: 650  ENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLR------FELEDEGKAMLASLRS 703
            EN LQQ+ +   Q L  A +E +   +   E+  +T +      +  E E  A    L+S
Sbjct: 993  ENKLQQQLTQAAQELA-AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051

Query: 704  ELNHQHAAAIDLLRHNHH--------QELAAAKMELERSIDISRRQSKEHICRITDLQEE 755
                   A  DL+ + +         QEL  AK  LE+      +Q +E    + D+Q+E
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111

Query: 756  LRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRE 815
               +E    EL  E   L E      +E++ + ++ +   +E  +  +LE ++E   +++
Sbjct: 1112 KSLKE---KELVNEKSKLAE-----IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD 1163

Query: 816  SKPEDIQMITELKAMLTERDQIIKKLIEDNK 846
            +K    Q++ + K  L  +   +K  +E  K
Sbjct: 1164 AK----QLLIQQKLELQGKADSLKAAVEQEK 1190



 Score =  134 bits (338), Expect = 3e-31
 Identities = 204/952 (21%), Positives = 410/952 (43%), Gaps = 152/952 (15%)

Query: 24   EAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLK 83
            EA+    +   S E++ + ++ EE      Q +    K  +   E   A    EI ++ K
Sbjct: 123  EAKPDGLVTDSSAELQSLEQQLEE-----AQTENFNIKQMKDLFEQKAAQLATEIADI-K 176

Query: 84   SQQDHSASVNKGQEKAEELHRMEVESLNK---MLEELRLE--RKKLIEDY---EGKLNKA 135
            S+ D   S+   +E AE+      E LNK   ++++L+ E  ++  IED    + +L + 
Sbjct: 177  SKYDEERSL---REAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQV 233

Query: 136  QSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDE 195
            Q+  +    TL+R +           EK  D  K+ Q Q A    TI +L++EL     E
Sbjct: 234  QTLMDNM--TLERER---------ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQE 282

Query: 196  AGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEV------------ES 243
                + + QKL++++       Q L + L   ++    L  KH E             + 
Sbjct: 283  VAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK 342

Query: 244  ELAAARERLQQQASDLVLKASHIGMLQATQMTQEV--TIKDLESEKSRVNERLSQLEEER 301
            +L   + + +  AS+  L   H+ + +  + TQ++   + ++E++   +     QL+++R
Sbjct: 343  DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 402

Query: 302  AFLRSKTQSLDEEQKQ---QILELEKKVNEA-----------------KRTQQEYYEREL 341
                     L  E  Q   ++LE E+++ EA                 K  Q    + +L
Sbjct: 403  EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462

Query: 342  KNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEE------- 394
              L+ +L+E+VT   E   +   +   + H   +A+  +     ++ Q DLE+       
Sbjct: 463  SRLEEQLKEKVTNSTELQHQL--DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520

Query: 395  ------------QHNKDKLNLEEDK------------------NQLQ-------QELENL 417
                        Q +K+ ++L E +                  NQLQ       +++  L
Sbjct: 521  KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL 580

Query: 418  KEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD----- 472
             E L+++  +  Q   +L D V++ +  L +A+  + SL+ S   L ++L+ +K+     
Sbjct: 581  TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL 640

Query: 473  --SLKETKDALLNVEGELEQER---QQHEETIAAMKEEEKLKVDKMAHDLE--IKWTENL 525
               +K   + LL+ E     +R   Q H +T     ++++ +++K+   L+      ++ 
Sbjct: 641  DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK 700

Query: 526  RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKK------VEDLLNQISL 579
            ++ CS+L   L+ +++E   S   +  +L+ + K    DS + K      ++DL  Q   
Sbjct: 701  QEHCSQLESHLK-EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ-RQ 758

Query: 580  LKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLA--FQT 637
            L  +LE++ ++    L+  +   +  R  L ++ E LE   Q+  K  +E  +L   F+T
Sbjct: 759  LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818

Query: 638  MEEEKEKEQRALENHLQQKHSAELQSL---KDAHRESMEGFRIEMEQELQTLR-----FE 689
            + +E + +   L N +Q     ELQ +   K+A    +   + ++ +   +L+     FE
Sbjct: 819  LSQETKIQHEELNNRIQTT-VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877

Query: 690  LEDE-GKAMLASLR---SELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEH 745
             E++ GKA +  L     EL HQ    + +   N  +E    + EL++S++  +  S + 
Sbjct: 878  KENQKGKAAILDLEKTCKELKHQ----LQVQMENTLKE----QKELKKSLEKEKEASHQL 929

Query: 746  ICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLE 805
               +  +QE+L   ++ + + +KE Q L  NI+ L +  E K K+I  ++ E    + L+
Sbjct: 930  KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAV-LQ 988

Query: 806  EMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRET 857
            + E +  +++   +  Q +   K  ++      +K  E  K  Q +   RE+
Sbjct: 989  KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1040



 Score =  119 bits (299), Expect = 1e-26
 Identities = 188/936 (20%), Positives = 397/936 (42%), Gaps = 149/936 (15%)

Query: 1    MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMS-----REVEEIRRKFEEKLRSFGQL 55
            +K++     E      +  Q   E Q +Q+  T        ++E++ R+  +K +    L
Sbjct: 469  LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 528

Query: 56   QVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLE 115
            +   +K K      L    R ++   +++ +  +A +N+ QEK   L   +V  L + L+
Sbjct: 529  EALLQKSKENI--SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE-QVTQLTEKLK 585

Query: 116  ELRLERKKLIEDYEGKLNKAQSFYERELD---TLKRSQLFTAESLQASKEKEADLRKEFQ 172
                  K+  E+   ++ + ++      D   +L+ S       L  SKEK + L  + +
Sbjct: 586  NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645

Query: 173  G--------------QEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ 218
                           Q A L+  +   +  LQ  Q E   +  +  ++   L   + +  
Sbjct: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705

Query: 219  VLQKQLDDAKEGEMALLSKHKEVES----------ELAAARER----LQQQA---SDLVL 261
             L+  L + KE  ++L  K +E+E           E+ A++E+    LQQQ    +DL L
Sbjct: 706  QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765

Query: 262  KASHIGMLQATQMTQEV---TIKDLESEKSR---VNERLSQLEEERAFLRSKTQSLDEEQ 315
            +A+ +   +  +M +E+   T  DL+ +      + ++L++ EEE+  L+   ++L +E 
Sbjct: 766  RATELS--KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823

Query: 316  KQQILELEKKVN------EAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWK 369
            K Q  EL  ++       +  + ++E    EL  ++ +L +    L  + S+  +E    
Sbjct: 824  KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE---- 879

Query: 370  HHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEV---LEDKLN 426
                       AI D +K   +L+ Q      N  +++ +L++ LE  KE    L+ +LN
Sbjct: 880  -----NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934

Query: 427  TANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEG 486
            +  +++   Q+ ++++E+     +G I  L+ S E+ + +++  +  LK        +E 
Sbjct: 935  SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994

Query: 487  ELEQERQQHEETIAAMKEE---------------EKLKVDKMAHDLEIKWTENLRQECSK 531
            +L+Q+  Q  + +AA KE+               ++L+ D    + E+  T   RQ+   
Sbjct: 995  KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT---RQDLKS 1051

Query: 532  LREELRLQHEE-----DKKSAMSQLLQ-LKDREKNAARDSWQKK---------VEDLLNQ 576
            + E+L L  E+     ++    ++L+Q LK  +    +DS +K+         ++D+  +
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111

Query: 577  ISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQ 636
             SL ++ L  + S+    +++++ +  +E  +L +EL+  + +  +   +LK+A  L  Q
Sbjct: 1112 KSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ 1170

Query: 637  TMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKA 696
               E + K         Q+K + ++  LKD         +++ E+E      EL+ E   
Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQI--LKD---------QVKKEEE------ELKKEFIE 1213

Query: 697  MLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEEL 756
              A L SE+  +           H +  A   M++    +            +  +++E 
Sbjct: 1214 KEAKLHSEIKEKEVG-----MKKHEENEAKLTMQITALNE-----------NLGTVKKEW 1257

Query: 757  RHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRES 816
            +  +  +SEL+K+   L   I+ L   ++             N Q     + E+ L  E 
Sbjct: 1258 QSSQRRVSELEKQTDDLRGEIAVLEATVQ-------------NNQDERRALLERCLKGEG 1304

Query: 817  KPEDIQ-MITELKAMLTERDQIIKKLIEDNKFYQLE 851
            + E +Q  + EL+  L      +++L  +N+  Q++
Sbjct: 1305 EIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 144/656 (21%), Positives = 280/656 (42%), Gaps = 85/656 (12%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRR----KFEEKLRSFGQLQV 57
            K+QAL + +  +    D++L   A  + + + M +E+    R    K  E L S  Q   
Sbjct: 746  KEQALQDLQQQRQLNTDLEL--RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLT 803

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
            + E++K++  +D +   +       +++  H    N+ Q    EL ++++E    ++ EL
Sbjct: 804  KQEEEKQILKQDFETLSQ-------ETKIQHEELNNRIQTTVTELQKVKMEK-EALMTEL 855

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
               + KL +     L  ++S +E+E    K + L   ++ +  K +     +    ++  
Sbjct: 856  STVKDKLSK-VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 914

Query: 178  LRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSK 237
            L+K++ K K     ++ E  S+ ++  + Q  L   E   Q LQ  +++ K+       +
Sbjct: 915  LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974

Query: 238  HKEVESELAAA-----------RERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESE 286
             + ++ EL  A           +++L Q A +L  +   I +LQ      + T K L+S+
Sbjct: 975  IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034

Query: 287  KSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQS 346
                  R S+L   R  L+S  + L   Q+  I    +  N+ K  Q      ELK  ++
Sbjct: 1035 ---FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ------ELKTAKA 1085

Query: 347  RLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKL-NLEE 405
             LE++        S   E+   +   A++ +       K+K   + E  + K KL  +EE
Sbjct: 1086 TLEQD--------SAKKEQQLQERCKALQDIQ------KEKSLKEKELVNEKSKLAEIEE 1131

Query: 406  DKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQN 465
             K + ++E+  L E L+     + +EI +L+D  +   Q     +G   SL+ + E+ + 
Sbjct: 1132 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191

Query: 466  ELDLTKDSLKETKDAL----LNVEGELEQE-------RQQHEET-------IAAMKE--- 504
               + KD +K+ ++ L    +  E +L  E        ++HEE        I A+ E   
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLG 1251

Query: 505  ---EEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA 561
               +E     +   +LE K T++LR E + L  E  +Q+ +D++ A+ +     + E   
Sbjct: 1252 TVKKEWQSSQRRVSELE-KQTDDLRGEIAVL--EATVQNNQDERRALLERCLKGEGE--- 1305

Query: 562  ARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELE 617
              +  Q KV +L  ++     N    + +     Q LQ + TQ   R   E  E++
Sbjct: 1306 -IEKLQTKVLELQRKL----DNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score =  144 bits (363), Expect = 4e-34
 Identities = 202/907 (22%), Positives = 410/907 (45%), Gaps = 121/907 (13%)

Query: 20   QLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQ 79
            +L AEA+    +     + +    KF +  RS  Q +   E+ +R A E   A +  +  
Sbjct: 1440 RLLAEAE--SELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQET--AVNLVKAD 1495

Query: 80   ELLKSQQDHSASVNKGQEKAEELHR----------MEVESLNKMLEELRLERKKLIEDYE 129
            + L+S Q  +  + + + K EE+ +           + + L+K  E+L  E +KL +D E
Sbjct: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555

Query: 130  GKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQE---AILRKTIGKLK 186
                 A+   +  L  LK S++     LQA + +   L+ +   Q+   A+L + +G  K
Sbjct: 1556 ----MAERNEDHHLQVLKESEVL----LQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK 1607

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAE-------NNVQVLQKQLDDAKEGEMALLSKHK 239
             EL ++Q   GS++     LQ AL + E       N+++ ++  L++    +  L  +  
Sbjct: 1608 EELHLLQ---GSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQIS 1664

Query: 240  EVESELAAARERLQQQASDL--VLK--ASHIGMLQATQMTQEVTIKDLESEKSRVNERLS 295
            E +++L   ++ ++++  +L  VL+  + H   L+      ++   +L+  K + ++R+S
Sbjct: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724

Query: 296  QLEEER-AFLRSKT-----QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLE 349
            +LE+ + A L  K      Q + ++QK +I E +K++ E  + + E    E + LQS +E
Sbjct: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEI-EWQKQLLERDKREIERMTAESRALQSCVE 1783

Query: 350  ---EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK---------KKLQMDLEEQHN 397
               +E   L E      ++LA    +   A  ++ +            +KLQ +L+ Q N
Sbjct: 1784 CLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELD-QLN 1842

Query: 398  KDKLNLEEDKNQLQQELENLKEVL----------EDKLNTANQEIGHL---QDMV----R 440
            +DKL+L  D + +QQ+L+  +E +          +D LN A Q++ H    QD++     
Sbjct: 1843 RDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQT 1902

Query: 441  KSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIA 500
            + ++ +          Q  +E  Q +L + ++ ++E K  L+  E  + Q  Q+  E+  
Sbjct: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQE-MMFQRLQKERESEE 1961

Query: 501  AMKEEEKLKVDKMAHDLEIKWTEN---LRQECSKL---REELRLQHEEDK------KSAM 548
            +  E  K+ + +  H LE + T+    L Q  SK+    E +R   EE++      K+  
Sbjct: 1962 SKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLS 2021

Query: 549  SQLLQLKDREKNAARDSW-----QKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFT 603
                QL +RE+     S      QK+ + +    SLL+     +  +++  +  L+    
Sbjct: 2022 QTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK 2081

Query: 604  QERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQS 663
             +R +L + L E ++++    K +    ++A    ++  E+ +R ++   Q ++      
Sbjct: 2082 IQRSQLEKNLLEQKQENSCIQKEMATIELVA----QDNHERARRLMKELNQMQYEYTELK 2137

Query: 664  LKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHH-- 721
             + A+++ +E  ++E+   ++TL+ E++DE +  L +L   L    A    +L  N +  
Sbjct: 2138 KQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLE 2197

Query: 722  QELAAAKMEL---------ERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQH 772
             EL + K  L         E  ++ S+    +   R   L+E+LRHRE     L  +++H
Sbjct: 2198 GELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHRE---DRLKAQLRH 2254

Query: 773  LHENISALTKELE--FKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAM 830
                   ++K+ E   KGK        S ++ +++ + E      +       +++L++ 
Sbjct: 2255 ------CMSKQAEVLIKGKRQTEGTLHSLRR-QVDALGELVTSTSADSASSPSLSQLESS 2307

Query: 831  LTERDQI 837
            LTE  Q+
Sbjct: 2308 LTEDSQL 2314



 Score =  118 bits (296), Expect = 2e-26
 Identities = 189/878 (21%), Positives = 380/878 (43%), Gaps = 140/878 (15%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLR-------SFGQ 54
            K+Q+  E E   H ++D+        +Q   ++  EVEE+ R  +++ +       +   
Sbjct: 1349 KRQSEKEMEELHHNIDDL--------LQEKKSLECEVEELHRTVQKRQQQKDFIDGNVES 1400

Query: 55   LQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKML 114
            L  + E +K L   +        I++ L  ++      ++   +AE       E     +
Sbjct: 1401 LMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAV 1460

Query: 115  EELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQ 174
            E+    ++ L++         +   E  ++ +K  Q     SLQA  +   DL +    Q
Sbjct: 1461 EKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQL--RSLQADAK---DLEQHKIKQ 1515

Query: 175  EAILR---KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGE 231
            E IL+   K +    ++ Q +  +   L ++ QKLQ  + +AE N       L   KE E
Sbjct: 1516 EEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNED---HHLQVLKESE 1572

Query: 232  MALLSKHKEVE---SELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKD-LESEK 287
            + L +K  E+E   S++ + ++ +      L  K   + +LQ + +  +  +++ L   +
Sbjct: 1573 VLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGE 1632

Query: 288  SRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSR 347
            + V E+ + + E ++ L        EE   Q  EL  +++E K TQ    ++E++  +  
Sbjct: 1633 TEVTEKCNHIREVKSLL--------EELSFQKGELNVQISERK-TQLTLIKQEIEKEEEN 1683

Query: 348  LEEEVTQLNEAHSKT---LEELAWKHH--MAIEAVHSNAIRDKKKLQMDLEEQHNKDKLN 402
            L+  + Q+++  ++    L+ L  ++H    ++  H   + + +K Q+ + E+   +  N
Sbjct: 1684 LQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEE-KLELEN 1742

Query: 403  LEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQER 462
            L++   Q + E+E  K++LE       ++   ++ M  +S     + +  +  L   +E 
Sbjct: 1743 LQQISQQQKGEIEWQKQLLE-------RDKREIERMTAESR----ALQSCVECLSKEKED 1791

Query: 463  LQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWT 522
            LQ + D+ +  L +TK  L                  AA +E  K++   +   LE+   
Sbjct: 1792 LQEKCDIWEKKLAQTKRVL------------------AAAEENSKMEQSNL-EKLELN-V 1831

Query: 523  ENLRQECSKL-REELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLK 581
              L+QE  +L R++L L ++    SAM Q LQ    EK  A +S Q+++ ++ + ++L K
Sbjct: 1832 RKLQQELDQLNRDKLSLHNDI---SAMQQQLQ----EKREAVNSLQEELANVQDHLNLAK 1884

Query: 582  QNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEE 641
            Q+L +  ++ Q  L         E+ RL +++ E   + +   K             EE 
Sbjct: 1885 QDL-LHTTKHQDVL-------LSEQTRLQKDISEWANRFEDCQKE------------EET 1924

Query: 642  KEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASL 701
            K+++ + L+N +++        LK   +E M           Q L+ E E E ++ L + 
Sbjct: 1925 KQQQLQVLQNEIEEN------KLKLVQQEMM----------FQRLQKERESE-ESKLETS 1967

Query: 702  RSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREH 761
            +  L  Q        +H   +EL   K +L++ +  S+  + E   R+  LQEE R  E 
Sbjct: 1968 KVTLKEQ--------QHQLEKELTDQKSKLDQVL--SKVLAAEE--RVRTLQEEERWCE- 2014

Query: 762  HISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDI 821
                L+K +      +S   ++L  K  E+L ++ E++       +     + E K  + 
Sbjct: 2015 ---SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEK 2071

Query: 822  QMITELKAMLTERDQIIKKLIE---DNKFYQLELVNRE 856
            Q+ +  +A+  +R Q+ K L+E   +N   Q E+   E
Sbjct: 2072 QVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIE 2109



 Score =  100 bits (250), Expect = 5e-21
 Identities = 156/681 (22%), Positives = 302/681 (44%), Gaps = 89/681 (13%)

Query: 58   QFEKDKRLALEDLQAAHRREIQELLKSQQDH-SASVNKGQEKAEELHRMEVESLN----- 111
            + E D++L  + +       +   L+ ++   SA+  +  E  +E+ + E + L      
Sbjct: 415  KMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEF 474

Query: 112  KMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEF 171
            K LEE  ++ KK+ E  +  L K  S   + ++ L++  L     ++  K++ A  +KE 
Sbjct: 475  KQLEEA-IQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEI 533

Query: 172  QGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGE 231
            +  +  +     K      M   ++G         +  L I     Q L+ +LD+     
Sbjct: 534  KDLQIAIDSLDSKDPKHSHMKAQKSGK--------EQQLDIMNKQYQQLESRLDEILSRI 585

Query: 232  MALLSKHKEVESELA----AARERLQQQASDLVLKAS-HIGML--QATQMTQEVTIKDLE 284
                 + K++E +L     AA E L++    ++     ++G +  QATQ   E   + L 
Sbjct: 586  AKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNEC--RKLR 643

Query: 285  SEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEA-------KRTQQEY- 336
             EK  + +RL+++E+ER  L        E  ++++ ELE  + E        ++TQ +  
Sbjct: 644  DEKETLLQRLTEVEQERDQLEIVAMDA-ENMRKELAELESALQEQHEVNASLQQTQGDLS 702

Query: 337  -YERELK---NLQ----SRLEEE---VTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDK 385
             YE EL+   NL+    ++L+EE   VT+L +     L+    K   A++     A   +
Sbjct: 703  AYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSE 762

Query: 386  KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLE---DKLNTANQEIGHLQDMVRKS 442
            +K Q +  E H K K +L++D N L+Q+L++ +  L    D L    +    + ++ RK 
Sbjct: 763  EKEQEN-SELHAKLK-HLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKL 820

Query: 443  EQGLGS------AEGLIASLQDSQERLQNELDLTKDSLKET--KDALLNVEGELEQER-- 492
            + G G       ++ L  SL D Q++    L  +K    E   ++  L  E  L+QE+  
Sbjct: 821  KLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLA 880

Query: 493  --QQHEETIAAMKEEEKLKVDKMAHDLEIKWTEN----LRQECSKLRE-----ELRLQHE 541
              Q+          E ++  DK  H+  I+  EN    L++    + E     +L+LQ  
Sbjct: 881  TGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEA 940

Query: 542  EDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQ 601
            +++K  +  L QL++ EK       +KK+ED  +Q  +   + E         L++L+  
Sbjct: 941  DEEKERI--LAQLRELEK-------KKKLEDAKSQEQVFGLDKE---------LKKLKKA 982

Query: 602  FTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQ-QKHSAE 660
                 +  T EL   ++Q +  H ++ + +    + ++E +   ++A +      +  AE
Sbjct: 983  VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042

Query: 661  LQSLKDAHRESMEGFRIEMEQ 681
            ++ L++  R+  E FR+EME+
Sbjct: 1043 IELLQNLLRQKGEQFRLEMEK 1063



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 160/790 (20%), Positives = 332/790 (42%), Gaps = 161/790 (20%)

Query: 100 EELHRMEVESLNKMLE--ELRLERKKLIEDYEG--KLNKA---------QSFYERELDTL 146
           EE+ R+E +   KM+E  EL+ ++ + +E+ +   KLNK+         QS  E + D  
Sbjct: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329

Query: 147 KRSQLFTAESLQASK--EKEADLRKE---------------FQGQEAILRKT------IG 183
            +++L   ++++ ++  +K+ +L +E               +  + A + K       IG
Sbjct: 330 TKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389

Query: 184 KLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ----------VLQKQLDDAKEGEMA 233
           K + +  M   E+  ++D  Q +Q      +  ++           L  QL+D ++   A
Sbjct: 390 KSRYKRNMFATES-YIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISA 448

Query: 234 LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER 293
             ++  E+  E+  A +++ +   +       I + + ++  +++  K L      VN+ 
Sbjct: 449 AQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNK- 507

Query: 294 LSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVT 353
                     LR +   L+ + ++Q  E+  K            ++E+K+LQ  ++    
Sbjct: 508 ----------LRQEALDLELQMEKQKQEIAGK------------QKEIKDLQIAID---- 541

Query: 354 QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMD-LEEQHNKDKLNLEEDKNQLQQ 412
                   +L+    KH       H  A +  K+ Q+D + +Q+ + +  L+E  +++ +
Sbjct: 542 --------SLDSKDPKHS------HMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAK 587

Query: 413 ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD 472
           E E +K+ LE++L          +  +  +E      EG+I+ LQ+    ++ +    ++
Sbjct: 588 ETEEIKD-LEEQLT---------EGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637

Query: 473 ---SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQEC 529
               L++ K+ LL    E+EQER Q E  I AM                    EN+R+E 
Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERDQLE--IVAMD------------------AENMRKEL 677

Query: 530 SKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLN----QISLLKQNLE 585
           ++L   L+ QHE +     +Q              +++ ++E  LN    + + LK+ LE
Sbjct: 678 AELESALQEQHEVNASLQQTQ----------GDLSAYEAELEARLNLRDAEANQLKEELE 727

Query: 586 IQLSQSQTSLQQLQAQFTQERQRLTQEL------EELEEQHQQRHKSLKEAHVLAFQTME 639
                +Q     LQA+  +ERQ L   L      EE E+++ + H  LK       Q   
Sbjct: 728 KVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKH-----LQDDN 782

Query: 640 EEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLA 699
              +++ +  +NHL       ++  + A R      ++++      +    +  GK+ LA
Sbjct: 783 NLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKS-LA 841

Query: 700 SLRSELNHQHAAA-----IDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQE 754
            L+ + +   A +        +R    QE  A + E   +     RQ+ E       +  
Sbjct: 842 DLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALE-ARMNF 900

Query: 755 ELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIR----LEEMEEK 810
           + R  E  I +++ E+ +L EN+ ++    E +G   L+++    ++ R    L E+E+K
Sbjct: 901 DKRQHEARIQQMENEIHYLQENLKSME---EIQGLTDLQLQEADEEKERILAQLRELEKK 957

Query: 811 YLMRESKPED 820
             + ++K ++
Sbjct: 958 KKLEDAKSQE 967



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 120/537 (22%), Positives = 224/537 (41%), Gaps = 82/537 (15%)

Query: 4    QALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDK 63
            Q LTE E  + ++E + + AE         M +E+ E+    +E+      LQ Q + D 
Sbjct: 651  QRLTEVEQERDQLEIVAMDAE--------NMRKELAELESALQEQHEVNASLQ-QTQGDL 701

Query: 64   RLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKK 123
                    +A+  E++  L  +   +  + +  EK   L ++E  +L   LE+   ER+ 
Sbjct: 702  --------SAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEK---ERQA 750

Query: 124  LIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIG 183
            L    +  L KAQ               F+ E  Q + E  A L K  Q    +L++ + 
Sbjct: 751  L----KNALGKAQ---------------FSEEKEQENSELHAKL-KHLQDDNNLLKQQLK 790

Query: 184  KLKTELQMVQD------EAGSLLDKCQKLQTALAIAENNVQ----VLQKQLDDAKEGEMA 233
              +  L  V D      E  + +D+ ++ +  L   E N+     VL K L D ++    
Sbjct: 791  DFQNHLNHVVDGLVRPEEVAARVDELRR-KLKLGTGEMNIHSPSDVLGKSLADLQKQFSE 849

Query: 234  LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER 293
            +L++ K    E A  RER  Q+   L  +    G  +  Q  +      +  +K +   R
Sbjct: 850  ILARSKWERDE-AQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEAR 908

Query: 294  LSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKR--TQQEYYERELKNLQSRLEEE 351
            + Q+E E  +L+   +S++E Q    L+L++   E +R   Q    E++ K   ++ +E+
Sbjct: 909  IQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQ 968

Query: 352  VTQLNEAHSKTLEELAWKHHMA----------IEAVHSNAIRDKKKLQMDLEE--QHNKD 399
            V  L++   K  + +A    +A          ++++H   ++  ++   +L+E  + ++ 
Sbjct: 969  VFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRK 1028

Query: 400  KLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGL--IASLQ 457
                  D  + + E+E L+ +L  K      E+        K+  G G+   +  I  L 
Sbjct: 1029 AAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-------EKTGVGTGANSQVLEIEKLN 1081

Query: 458  DSQER-------LQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEK 507
            ++ ER       LQN LDLT    K   + +L    EL +E     + I++M +  K
Sbjct: 1082 ETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFK 1138



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 55/267 (20%), Positives = 115/267 (43%), Gaps = 37/267 (13%)

Query: 583  NLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEK 642
            NLE ++S+ +  +Q L+++  +ER         +    +Q  K ++E H      ++E+K
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERW--------MRASKRQSEKEMEELHHNIDDLLQEKK 1371

Query: 643  EKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLR 702
              E    E H   +   + +   D + ES+    +E+E+ L+    ++ DE + +  +L 
Sbjct: 1372 SLECEVEELHRTVQKRQQQKDFIDGNVESLM-TELEIEKSLKH-HEDIVDEIECIEKTL- 1428

Query: 703  SELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHH 762
                        L R +  +E      E E  +  ++ ++K  + + TD +  L   E  
Sbjct: 1429 ------------LKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESD 1476

Query: 763  ISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRE------S 816
              EL++  Q    N+         K  + LR      + +   +++++ +++E      +
Sbjct: 1477 AEELERRAQETAVNL--------VKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAA 1528

Query: 817  KPEDIQMITELKAMLTERDQIIKKLIE 843
            K  D Q +++ K  LTE  Q ++K IE
Sbjct: 1529 KDSDFQCLSKKKEKLTEELQKLQKDIE 1555



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 79/367 (21%), Positives = 159/367 (43%), Gaps = 51/367 (13%)

Query: 544 KKSAMSQLLQLKDREKNAARD-SWQKKVEDLL------NQISLLKQNLEIQLSQSQTSLQ 596
           KK    ++L LK  + ++ +D S  K ++DL+      N +  L   L+  +   + SL+
Sbjct: 190 KKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLR-SLE 248

Query: 597 QLQAQ--FTQERQRLTQE--LEELEEQHQQRHKSLKEAHVL-AFQTMEEEKEKEQRAL-- 649
            L+ Q   TQ+RQ   +   LEE+E   +   K + E   L + QT   E+ K Q  L  
Sbjct: 249 SLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNK 308

Query: 650 ----ENHLQQKHSAELQSLKDAHRESMEGFRIEM----------EQELQTLRFELEDEGK 695
               E  LQ++   EL+S  +   E ++   IE+          EQEL   + + + E  
Sbjct: 309 SLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPL 368

Query: 696 AMLASLRSELNHQHAAAIDLLRHNHHQELAAAK---MELERSIDISRRQSKEHICRI--- 749
               S  +E++     +  + +  + + + A +   ++  +++ I + +  E +      
Sbjct: 369 NYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMN 428

Query: 750 ----TDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQ---QI 802
               T L  +L  +E  IS     +  LH+       E+E   ++ILR   E  Q    I
Sbjct: 429 LRGHTPLDTQLEDKEKKISAAQTRLSELHD-------EIEKAEQQILRATEEFKQLEEAI 481

Query: 803 RLEEMEE--KYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETNFN 860
           +L+++ E  K L+ +     +Q++ +L+    + +  ++K  ++    Q E+ + +   +
Sbjct: 482 QLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAID 541

Query: 861 KVFNSSP 867
            + +  P
Sbjct: 542 SLDSKDP 548



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 64/288 (22%), Positives = 118/288 (40%), Gaps = 39/288 (13%)

Query: 39   EEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEK 98
            EE R+  E  L +    ++ F+K +  A           +QE LKS ++     +   ++
Sbjct: 884  EEFRQACERALEA----RMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQE 939

Query: 99   AEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQ 158
            A+E    E E +   L E  LE+KK +ED   K  +     ++EL  LK++ + T++ L 
Sbjct: 940  ADE----EKERILAQLRE--LEKKKKLED--AKSQEQVFGLDKELKKLKKA-VATSDKLA 990

Query: 159  ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ 218
             +   E  + K+   Q   L  T+ K+  E      EA     K  +    L  AE  ++
Sbjct: 991  TA---ELTIAKD---QLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIE 1044

Query: 219  VLQKQLDDAKEGEMALLSKHK--------EVESELAAARERLQQQASDLVLKASHIGMLQ 270
            +LQ  L   ++GE   L   K            E+    E +++Q +++           
Sbjct: 1045 LLQNLL--RQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIA---------- 1092

Query: 271  ATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQ 318
              Q   ++T  D +     V E +++L  E ++      S+ +  K++
Sbjct: 1093 RLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  142 bits (357), Expect = 2e-33
 Identities = 207/952 (21%), Positives = 388/952 (40%), Gaps = 151/952 (15%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHV--------------------------------- 28
            K + L + E  K +VED+Q   E + +                                 
Sbjct: 424  KVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKL 483

Query: 29   ------QRIVTMSRE--VEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQE 80
                   R+ T+S +  + E+ +    +++   +L+ + E +K     D+  +  +EI  
Sbjct: 484  QRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS 543

Query: 81   LLK----SQQDHSASVNKGQE---KAEELHRMEV--------------ESLNKMLEELRL 119
            L +    ++ DH   +   +E     EE H+ E+              ESL   LE    
Sbjct: 544  LQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK 603

Query: 120  ERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILR 179
            E   +I  ++ KL  A + +++ ++ LK S    ++ L     + A+L+ + +      +
Sbjct: 604  ENSDVIALWKSKLETAIASHQQAMEELKVS---FSKGLGTETAEFAELKTQIEKMRLDYQ 660

Query: 180  KTIGKLKTELQMVQDEAGSLLDKCQ-KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKH 238
              I  L+ +    +      ++  + KL   +   EN+++ ++ +LD A++  +      
Sbjct: 661  HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV----- 715

Query: 239  KEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLE 298
             E+E  L     +LQ+      +K   + +LQA    Q   I +  S+     E+L  L+
Sbjct: 716  -EMEDTL----NKLQEAE----IKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 766

Query: 299  -------EERAFLRSKTQSLDEEQKQ-QILELEKKVNEAKRTQ--QEYYERELK--NLQS 346
                   E ++ ++   Q L+  +KQ + LE+EK    +K +   +E   RELK  NLQ 
Sbjct: 767  ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQE 826

Query: 347  RLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEED 406
             L  EV+Q+ E   K L+ L  K   A E     A+  ++ +Q  + + H K     EE 
Sbjct: 827  NL-SEVSQVKETLEKELQILKEKFAEASE----EAVSVQRSMQETVNKLHQK-----EEQ 876

Query: 407  KNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGL-----------GSAEGLIAS 455
             N L  +LE L+E L D +    +E    ++ + K+++ L           G     +  
Sbjct: 877  FNMLSSDLEKLRENLAD-MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 935

Query: 456  LQDS---QERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDK 512
            + D    +ER   EL L      E    L     ++  + +Q ++  A   EEEK ++++
Sbjct: 936  MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 995

Query: 513  MAHDLEIKWTENLRQECSKLR-------EELRLQHEEDKKSAMSQLLQLKDREKNAARDS 565
               DLE K  E    +C +L+        E + +HEE  ++    LL  +D+ K A  ++
Sbjct: 996  KLSDLE-KKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREEN 1054

Query: 566  WQKKVEDLLNQI-SLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRH 624
                   LL ++  L KQ  + + +Q+     Q+  Q T+E+      LE+ ++ + +  
Sbjct: 1055 -----SGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109

Query: 625  KSLKEAHVLAFQTMEE-EKEKEQRALENHLQQKHSAELQSLKDAHRE------SMEGFRI 677
              L        + +EE  K KE   +EN   ++   E+++LK A  +      +++   +
Sbjct: 1110 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1169

Query: 678  EMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDI 737
            ++ +EL   R E+    K  L   RS LN+Q    +        ++    K  L++SI I
Sbjct: 1170 KLAEELGRSRDEVTSHQK--LEEERSVLNNQ-LLEMKKRESKFIKDADEEKASLQKSISI 1226

Query: 738  SRRQSKEHICRITDLQEE---LRHREHHISELDKEVQHLHEN---ISALTKELEFKGKEI 791
            +     E    +  L+ E   LR        L   VQ L  +   +    K LE + KE 
Sbjct: 1227 TSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKEN 1286

Query: 792  LRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIE 843
             R  S S+     +  E++     ++   I  +  +   L  ++Q +K  +E
Sbjct: 1287 KRQLSSSSGNTDTQADEDE----RAQESQIDFLNSVIVDLQRKNQDLKMKVE 1334



 Score =  127 bits (318), Expect = 7e-29
 Identities = 160/751 (21%), Positives = 340/751 (45%), Gaps = 94/751 (12%)

Query: 31   IVTMSREVEEIRRKFEEKLRS----FGQLQVQFEK---DKRLALEDLQ-------AAHRR 76
            I +  + +EE++  F + L +    F +L+ Q EK   D +  +E+LQ       AAH +
Sbjct: 620  IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679

Query: 77   EIQEL-------LKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYE 129
            E++ L       +K +++   ++    +KAE+ H +E+E     L+E  ++ K+L E  +
Sbjct: 680  EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL-EVLQ 738

Query: 130  GKLNKAQSFYERELDTLKRSQ--LFTAESLQ-ASKEKEADLRKEFQGQEAILRKTIGKLK 186
             K N+     +     LK ++  L   ++L+ AS E +++++K  Q  EA   K I  L+
Sbjct: 739  AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA-EKQIKHLE 797

Query: 187  TELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLS-KHKEVESEL 245
             E      +A S+  + Q  +  L   + N+  +  Q+ +  E E+ +L  K  E   E 
Sbjct: 798  IEKNAESSKASSITRELQGRELKLTNLQENLSEVS-QVKETLEKELQILKEKFAEASEEA 856

Query: 246  AAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLR 305
             + +  +Q+  + L  K     ML +        + D+E++    +ER  QL + +  L 
Sbjct: 857  VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLE 916

Query: 306  SKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQ-----SRLEEEVTQLNEAHS 360
            +    + +       +L K  +E +  +++  E +LK  +     S L++ +  +     
Sbjct: 917  NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE 976

Query: 361  KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHN-------KDKLNLEEDKNQLQQE 413
            ++ +E A KH    E       R    L+  +E  HN       + +    E K + ++ 
Sbjct: 977  QSQQEAAKKH----EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI 1032

Query: 414  LENLKEVL---EDKLNTANQEIGHL--------------------QDMVRKSEQGLGSAE 450
            L+NL++ L   EDKL  A +E   L                    +D ++  EQ      
Sbjct: 1033 LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1092

Query: 451  GLIASLQDSQE---RLQNELD-LTKDSLKETKD-----ALLNVEGELEQERQQHEETIAA 501
              +ASL+D+++   +LQNELD L +++LK  ++      LL VE +  +E ++  ET+  
Sbjct: 1093 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1152

Query: 502  MKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA 561
               ++  ++  +  +  +K  E L +   ++    +L  EE++    +QLL++K RE   
Sbjct: 1153 AAAQKSQQLSALQEE-NVKLAEELGRSRDEVTSHQKL--EEERSVLNNQLLEMKKRESKF 1209

Query: 562  ARDSWQKKVEDLLNQIS-----LLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEEL 616
             +D+ ++K   L   IS     L +++ E++  +++ ++ + +    +    + Q LE  
Sbjct: 1210 IKDADEEKA-SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESD 1268

Query: 617  EEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFR 676
            + + + + K+L+         ++ ++ K Q +  +      + E +  +++  + +    
Sbjct: 1269 KVKLELKVKNLE---------LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1319

Query: 677  IEMEQELQTLRFELEDEGKAMLASLRSELNH 707
            ++++++ Q L+ ++E   +A L     +LN+
Sbjct: 1320 VDLQRKNQDLKMKVEMMSEAALNGNGDDLNN 1350



 Score =  117 bits (293), Expect = 5e-26
 Identities = 162/711 (22%), Positives = 287/711 (40%), Gaps = 133/711 (18%)

Query: 206  LQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK-EVESELAAARERLQQQASDLVLKAS 264
            LQ AL   + +++ L  + D  +  E+A  + H  E+E ELA AR+   Q   +L  K  
Sbjct: 353  LQEALKEKQQHIEQLLAERD-LERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD 411

Query: 265  HIG-MLQATQMTQEVTIKDLESEKSRVNE------------------------RLSQLEE 299
             +  M++A    +   +  LE EK +V +                        R+ +LE+
Sbjct: 412  QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQ 471

Query: 300  ERAFLRSKTQSLDEE----------QKQQILELEK-------KVNEAKRTQQEYYE---- 338
               F ++K   L  E          +K +I+ELEK       +V E +R  +        
Sbjct: 472  SLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDV 531

Query: 339  -------RELKNLQSRLE-------EEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRD 384
                   +E+ +LQ +LE        E+T L E H    EE   K   A+        ++
Sbjct: 532  DMSLSLLQEISSLQEKLEVTRTDHQREITSLKE-HFGAREETHQKEIKALYTATEKLSKE 590

Query: 385  KKKLQMDLEE--QHNKDKLNLEEDKNQL-----QQELENLKEVLEDKLNTANQEIGHLQD 437
             + L+  LE   + N D + L + K +      QQ +E LK      L T   E   L+ 
Sbjct: 591  NESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 650

Query: 438  MVRKSEQGLGSAEGLIASLQDSQERLQ-NELDLTKDSL----KETKDALLNVEGELEQER 492
             + K           + + QDS+      E++  +  L    KE +++L  +  +L++  
Sbjct: 651  QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE 710

Query: 493  QQH----EETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAM 548
             QH    E+T+  ++E E          +++K  E L+ +C++  + +        K+  
Sbjct: 711  DQHLVEMEDTLNKLQEAE----------IKVKELEVLQAKCNEQTKVID-NFTSQLKATE 759

Query: 549  SQLLQLKD-REKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQ 607
             +LL L   R+ ++   S  KK+   L       ++LEI+ +   +    +  +      
Sbjct: 760  EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 819

Query: 608  RLTQELEELEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQKHSAELQSLK 665
            +LT   E L E  Q +    KE  +L   F    EE    QR+++  + + H  E     
Sbjct: 820  KLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKE----- 874

Query: 666  DAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELA 725
                   E F + +  +L+ LR  L D    M A  R              +    ++L 
Sbjct: 875  -------EQFNM-LSSDLEKLRENLAD----MEAKFRE-------------KDEREEQLI 909

Query: 726  AAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELE 785
             AK +LE  I    + S ++  ++T + +ELR +E  + EL  ++   +EN S L K + 
Sbjct: 910  KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI- 968

Query: 786  FKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQ 836
                E + +++E +QQ   ++ EE+    E K  D++     K M T  +Q
Sbjct: 969  ----EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE-----KKMETSHNQ 1010



 Score =  116 bits (291), Expect = 9e-26
 Identities = 185/918 (20%), Positives = 381/918 (41%), Gaps = 183/918 (19%)

Query: 78   IQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERK---KLIEDYEGKLNK 134
            +QE LK +Q H   +   ++            + ++ +EL L R    + + + E K+++
Sbjct: 353  LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412

Query: 135  AQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQD 194
             ++  E       R ++     L+  K K  DL  +F+ +E  + K  G L+T+ ++   
Sbjct: 413  LRTMVE----AADREKVELLNQLEEEKRKVEDL--QFRVEEESITK--GDLETQTKLEHA 464

Query: 195  EAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVE-------SELAA 247
                   + ++L+ +L   +     LQ++L+D +   ++  S+  E+E        E+A 
Sbjct: 465  -------RIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517

Query: 248  ARERLQ--QQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE------ 299
             R RL+  + A D+ +  S +  + + Q   EVT  D + E + + E     EE      
Sbjct: 518  LRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI 577

Query: 300  ------------ERAFLRSKTQSLDEEQK-----------------QQILELEKKVNEAK 330
                        E   L+SK +  ++E                   QQ +E E KV+ +K
Sbjct: 578  KALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME-ELKVSFSK 636

Query: 331  ------------RTQQEY----YERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAI 374
                        +TQ E     Y+ E++NLQ++ + E      AH+K +E L  K    I
Sbjct: 637  GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE----RAAHAKEMEALRAKLMKVI 692

Query: 375  EAVHSN--AIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLK--EVLEDKLNTANQ 430
            +   ++  AIR K      L++  ++  + +E+  N+LQ+    +K  EVL+ K N   +
Sbjct: 693  KEKENSLEAIRSK------LDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746

Query: 431  EIGHLQDMVRKSEQGL--------GSAEG------------------------------- 451
             I +    ++ +E+ L         S+EG                               
Sbjct: 747  VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 806

Query: 452  -------------LIASLQDS-------QERLQNELDLTKDSLKETKDALLNVEGELEQE 491
                          + +LQ++       +E L+ EL + K+   E  +  ++V+  +++ 
Sbjct: 807  ASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQET 866

Query: 492  ----RQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSA 547
                 Q+ E+      + EKL+ + +A D+E K+ E   +E   ++ + +L+++  +   
Sbjct: 867  VNKLHQKEEQFNMLSSDLEKLR-ENLA-DMEAKFREKDEREEQLIKAKEKLENDIAEIMK 924

Query: 548  M-----SQLLQLKDREKNAARD--SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 600
            M     SQL ++ D  +   RD    Q K+       S L++++E    +++ S Q+   
Sbjct: 925  MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK 984

Query: 601  QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALEN--------- 651
            +  +E++ L ++L +LE++ +  H   +E      +   E K K +  L+N         
Sbjct: 985  KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE 1044

Query: 652  ----HLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLR--SEL 705
                  ++++S  LQ L++  +++ +    +  ++   +  ++  E    LASL    + 
Sbjct: 1045 DKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1104

Query: 706  NHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISE 765
            N +    +D L+ N+ + +       E  + +  ++ +E    I  L++    +   +S 
Sbjct: 1105 NAKLQNELDTLKENNLKNVEELNKSKE-LLTVENQKMEEFRKEIETLKQAAAQKSQQLSA 1163

Query: 766  LDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYL--MRESKPEDIQM 823
            L +E   L E +     E+    K        +NQ + +++ E K++    E K    + 
Sbjct: 1164 LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1223

Query: 824  ITELKAMLTERDQIIKKL 841
            I+   A+LTE+D  ++KL
Sbjct: 1224 ISITSALLTEKDAELEKL 1241


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  141 bits (355), Expect = 3e-33
 Identities = 227/960 (23%), Positives = 415/960 (43%), Gaps = 166/960 (17%)

Query: 27   HVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQE------ 80
            ++Q+I  +   +  +  + ++K + F Q  ++ EK+  L+    +    + +QE      
Sbjct: 1838 YLQQIDQLKERIAGLEEE-KQKNKEFSQT-LENEKNTLLSQISTKDGELKMLQEEVTKMN 1895

Query: 81   LLKSQ-QDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQ--- 136
            LL  Q Q+  + V K +E AEE    E + L + L     E    I +Y   +  AQ   
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEE----EKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN 1951

Query: 137  SFYERELDTLKR--SQLFTAESLQASKEK---EADLRKEFQGQEAILRKTIG------KL 185
               E E+  LK+  S+L   E  Q  KEK   E+++RKE+  +    +K  G      +L
Sbjct: 1952 ELLESEMKNLKKCVSEL-EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010

Query: 186  KTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVL-------QKQLDDAKEGEMALLSKH 238
            +  L+  Q E   L   C + Q  ++  E  V+ L       QK L+  KE     +   
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070

Query: 239  KEVESELAAARERLQQQASDLV-LKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQL 297
            K+ ++ELA+ +  L    S+   + A ++ + +  Q  +E     ++ +   +  RL Q 
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQA 2130

Query: 298  EEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNE 357
            EE+    +   Q   +  +++ + LE+ + E + T  +  ++E++ LQ  L+  VTQL  
Sbjct: 2131 EEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK-DKEVQQLQENLDSTVTQL-A 2188

Query: 358  AHSKTLEELAWKHHMAI------EAVHSNAIRDKK---KLQMD----LEEQHNKDKLNLE 404
            A +K++  L       I      E   S+AI+ K+   +L+ D    L++Q  +  +++E
Sbjct: 2189 AFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME 2248

Query: 405  EDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERL- 463
            E K  + + LE+ K++ E K  T  Q    LQ  V  + QG    + L++ L++++    
Sbjct: 2249 ELKINISR-LEHDKQIWESKAQTEVQ----LQQKVCDTLQG--ENKELLSQLEETRHLYH 2301

Query: 464  --QNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEE------KLKVDKMAH 515
              QNEL   +  LK  KD L ++   LE+ ++Q       ++++E      K   +++  
Sbjct: 2302 SSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361

Query: 516  DLEI--KWTENLRQECSKLRE------------------ELRLQHEEDKKSAMSQLLQLK 555
            DL+   + T  L +E +   +                  ELR QH+++ K   + L Q  
Sbjct: 2362 DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ-- 2419

Query: 556  DREKNAARDSWQKKVEDLLNQI-----SLLKQNLE--IQLSQSQTSLQQLQAQFTQERQR 608
            + E+N   +   KK  D  NQ+     ++ K+N++   QL     S+  LQ     +R R
Sbjct: 2420 EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ----NDRDR 2475

Query: 609  LTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQ-RALENHLQQKHS--AELQSLK 665
            +  + ++LEE+H      L++  ++     E  K KE+ R L +H+   +S  A+L +  
Sbjct: 2476 IVGDYQQLEERHLSI--ILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533

Query: 666  DAHRESM-EGFRIEMEQELQTLRFELED--EGKAMLASLRSELNHQHAAAIDLLRHNHHQ 722
              +RE + +   I+  Q+ Q L  +L+   E +   A L  +L     A  DL R     
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS--FN 2591

Query: 723  ELAAAKMELERSIDISRRQSKEHICRITDLQEE-----------LRHREHH--------- 762
             L   K +L + I+  +    +   ++T LQEE           ++  E H         
Sbjct: 2592 ALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651

Query: 763  ---ISELD----------------------KEVQHLHENISALTKELEFKGKEILRIRSE 797
               I+EL+                      KE++HLH +   +  E E   + +  +  +
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711

Query: 798  SNQQIRLEEMEEKYLM--RESKPEDIQMIT---ELKAMLTERDQIIKKLIEDNKFYQLEL 852
                  L EME+K LM  +E+K    Q+ +    + ++   RD   ++L E  + Y   L
Sbjct: 2712 ------LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASL 2765



 Score =  135 bits (341), Expect = 1e-31
 Identities = 203/960 (21%), Positives = 414/960 (43%), Gaps = 189/960 (19%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQ---ELLKSQQDHSASV 92
            +E E+   + +EK+R F + + Q    K L LE+     R E+    +  K   +   S 
Sbjct: 1665 QEAEQEMEEMKEKMRKFAKSKQQ----KILELEEENDRLRAEVHPAGDTAKECMETLLSS 1720

Query: 93   NKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDY-------EGKLNKAQSFYE----- 140
            N   ++  E  +ME E+L+K  + L  E+  L E+        EG ++K  +        
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780

Query: 141  -----------------RELDTLKRSQLFT-AESLQASKEKEADLRKEFQGQEAI----- 177
                              E D+L  S   T +ES+ ++K     + K+F   + I     
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840

Query: 178  ----LRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQ------LDDA 227
                L++ I  L+ E Q  ++ + +L ++   L + ++  +  +++LQ++      L+  
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900

Query: 228  KEGEMALLSKHKEV-ESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESE 286
             + E++ ++K KE  E E     ERL  Q ++L      IG         ++  + LESE
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAEL---NGSIGNYCQDVTDAQIKNELLESE 1957

Query: 287  KSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILE---------------------LEKK 325
               + + +S+LEEE+  L  +   ++ E +++ LE                     L++K
Sbjct: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEK 2017

Query: 326  VNEAKRTQQE---YYER-----------ELKNLQSRLEEEVTQLNEA----HSKTLEELA 367
              E K+ Q++   Y E+           E    +S+ + E+T+ N A    H K  +   
Sbjct: 2018 QQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077

Query: 368  WKHHMAIEAVHSNAIR---DKKKLQMDL-------------------------EEQHNKD 399
                + ++   S A R   D  KL+ +L                         EE+H K+
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKE 2137

Query: 400  KLNLEEDKNQLQQELENLKEVLED---KLNTANQEIGHLQDMVRKSEQGLGSAEGLIASL 456
            K N++E  + L++E  +L+E + +    LN  ++E+  LQ+ +  +   L +    ++SL
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL 2197

Query: 457  QDSQERLQNELDLTKDSLKETKDALLNVEGELEQER------QQHEETIAAMKEEEKLKV 510
            QD ++R+   +D  K   ++  DA+ + E E+  +       +     ++   EE K+ +
Sbjct: 2198 QDDRDRV---IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINI 2254

Query: 511  DKMAHDLEIKWTENLRQE------------------CSKLREELRLQHEEDKKSAM--SQ 550
             ++ HD +I W    + E                   S+L E   L H    + A   S+
Sbjct: 2255 SRLEHDKQI-WESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313

Query: 551  LLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLT 610
            L  LKD+  + + +S +K  E   N   +++Q  E  +  S+ S +QL+      R+ LT
Sbjct: 2314 LKSLKDQLTDLS-NSLEKCKEQKGNLEGIIRQQ-EADIQNSKFSYEQLETDLQASRE-LT 2370

Query: 611  QELEELEEQHQQRHKSL----KEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKD 666
              L E     +Q+  SL    +EA  +A   + ++ +KE + LEN L Q+    +  L++
Sbjct: 2371 SRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI-VLEE 2429

Query: 667  AHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAA 726
             ++++++    +  Q ++TL+            +++ E N Q  A +D    +  + +++
Sbjct: 2430 ENKKAVD----KTNQLMETLK------------TIKKE-NIQQKAQLD----SFVKSMSS 2468

Query: 727  AKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEF 786
             + + +R +   ++  + H+  I +  + ++      ++L +E++ L  ++  L  E   
Sbjct: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAK 2528

Query: 787  KGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK 846
               E+++ R + NQ I +++ ++K L+       +Q   EL+    + ++ +K+  E N+
Sbjct: 2529 LDAELIQYREDLNQVITIKDSQQKQLLE----VQLQQNKELENKYAKLEEKLKESEEANE 2584



 Score =  130 bits (326), Expect = 8e-30
 Identities = 199/902 (22%), Positives = 396/902 (43%), Gaps = 111/902 (12%)

Query: 1    MKQQALTEFEAYKHRVEDMQL-CAEAQHVQRIVTMSREVEEIRRKFEEKLRSFG------ 53
            +  +A    E+ + ++E  QL  A  +H++ +     E++++  K EE +          
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418

Query: 54   -------QLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRME 106
                   Q ++  ++D   AL        +E  E +K  Q     + +  E+  E  R +
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK 1478

Query: 107  VESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEAD 166
             + + + L+   + RK+ +++ +  L +  S     ++ L +S L   ES  +++ KE D
Sbjct: 1479 -QQIQRKLQAALISRKEALKENKS-LQEELSLARGTIERLTKS-LADVESQVSAQNKEKD 1535

Query: 167  LRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDD 226
                  G+ A+L++   KL TE+     E  SL   C+ L+ AL     + + L K+++ 
Sbjct: 1536 T---VLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592

Query: 227  AKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGML--QATQMTQEV--TIKD 282
             K  ++A  ++ +E   EL    E L Q   ++  +A  I  +     Q  QE+   ++ 
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652

Query: 283  LESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEK-------KVNEAKRTQQE 335
             E+ K    ++L + E+E   ++ K +   + ++Q+ILELE+       +V+ A  T +E
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712

Query: 336  YYERELKNLQSRLE--EEVTQLNEAHSKTLEELAWKHHMAIEAV----HSNAIRDKKKLQ 389
              E  L +  S  E  E V    E  SK  + L  +     E V    H       K+  
Sbjct: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772

Query: 390  MDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSA 449
            ++  E+H+      EE    +  E E      +D L+ +       +    +S     SA
Sbjct: 1773 LEATEKHDNQTNVTEEGTQSIPGETEE-----QDSLSMST------RPTCSESVPSAKSA 1821

Query: 450  EGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLK 509
               ++    S + + N L    D LKE       + G LE+E+Q+++E    ++ E+   
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQI-DQLKE------RIAG-LEEEKQKNKEFSQTLENEKNTL 1873

Query: 510  VDKMA-HDLEIKW-----------TENLRQECS---KLREELRLQHEEDKKSAMSQLLQL 554
            + +++  D E+K             + +++E S   KL+E    + ++ ++  M+QL +L
Sbjct: 1874 LSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAEL 1933

Query: 555  KDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELE 614
                 N  +D    ++++ L +  +  +NL+  +S+ +   QQL  + T+    + +E  
Sbjct: 1934 NGSIGNYCQDVTDAQIKNELLESEM--KNLKKCVSELEEEKQQLVKEKTKVESEIRKEY- 1990

Query: 615  ELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALEN---HLQQKHSA---ELQSLKDAH 668
             LE+    + +   ++H    Q + +EK++E + L+      Q+K SA    +++L+   
Sbjct: 1991 -LEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQ 2049

Query: 669  RESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHN--------H 720
             ES +   I  E   Q +  E   + +A LAS +  L+   + A  +L  N         
Sbjct: 2050 TESQKDLEITKENLAQAV--EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS 2107

Query: 721  HQELAAAKMELERSIDISRR---QSKEHICRITDLQEELR-------HREHHISEL---- 766
            ++E   ++M+ ++  D+ RR     ++H+    ++QE+L        H E  I E+    
Sbjct: 2108 NKESVKSQMK-QKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166

Query: 767  ---DKEVQHLHENISALTKELEFKGKEILRIRSESNQQI-RLEEMEEKYL-MRESKPEDI 821
               DKEVQ L EN+ +   +L    K +  ++ + ++ I   ++ E K+    +SK E+I
Sbjct: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226

Query: 822  QM 823
            ++
Sbjct: 2227 RL 2228



 Score =  119 bits (297), Expect = 2e-26
 Identities = 181/894 (20%), Positives = 396/894 (44%), Gaps = 112/894 (12%)

Query: 1    MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
            +K++   E E  K  +E +Q    AQ      + ++E++E+ ++ +++++   +  ++++
Sbjct: 1976 VKEKTKVESEIRKEYLEKIQ---GAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ 2032

Query: 61   KDKRLALEDLQAAH---RREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEEL 117
             +K  ALE    A    + E Q+ L+  +++ A   + ++KA+     E+ S   +L++ 
Sbjct: 2033 -EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQA----ELASFKVLLDDT 2087

Query: 118  RLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI 177
            + E  +++ D      + QS  E     +K+        L+ ++EK    +K  Q +   
Sbjct: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDA 2147

Query: 178  LRK-------TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQ----KQLDD 226
            LR+       TIG+++  L     E   L +      T LA    ++  LQ    + +D+
Sbjct: 2148 LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207

Query: 227  AKEGEM----ALLSKHKEV---ESELAAARERLQQQASDL------VLKASHIGMLQATQ 273
            AK+ E     A+ SK +E+   E   +  +++L+Q +  +      + +  H   +  ++
Sbjct: 2208 AKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK 2267

Query: 274  MTQEVTI--KDLESEKSRVNERLSQLEEERAFLRS------KTQSLDEEQKQQILELEKK 325
               EV +  K  ++ +    E LSQLEE R    S      K +S  +  K Q+ +L   
Sbjct: 2268 AQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS 2327

Query: 326  VNEAKRT---------QQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEA 376
            + + K           QQE   +  K    +LE ++    E  S+  EE+  K    I  
Sbjct: 2328 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISL 2387

Query: 377  VHSNAIRDKKKLQM---DLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIG 433
            +       ++ +Q+   +L +QH+K+   LE   +Q ++E   L+E  +  ++  NQ + 
Sbjct: 2388 LSGK----EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME 2443

Query: 434  HLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQ 493
             L+ + +++ Q     +  + S+      LQN+ D      ++ ++  L++  E +Q  Q
Sbjct: 2444 TLKTIKKENIQQKAQLDSFVKSMSS----LQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2499

Query: 494  QHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQ 553
            +       +KEE +     M         ++L  E +KL  EL +Q+ ED    ++Q++ 
Sbjct: 2500 EAAAENNKLKEEIRGLRSHM---------DDLNSENAKLDAEL-IQYRED----LNQVIT 2545

Query: 554  LKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFT---QERQRLT 610
            +KD ++    +   ++ ++L N+ +     LE +L +S+ + + L+  F    +E+Q L+
Sbjct: 2546 IKDSQQKQLLEVQLQQNKELENKYA----KLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601

Query: 611  QELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRE 670
            +E+E L+    Q  + +          ++EE        +  ++++    L +L  + ++
Sbjct: 2602 KEIESLKVSISQLTRQVT--------ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653

Query: 671  SMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQ------EL 724
             +     E+E+EL  ++ E   +   +   L+ EL H H  A  ++R+          EL
Sbjct: 2654 RIA----ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA-GIMRNETETAEERVAEL 2708

Query: 725  AAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKEL 784
            A   +E+E+ + +  +++K        L  +++     +S L     H +E +  L ++ 
Sbjct: 2709 ARDLVEMEQKLLMVTKENK-------GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKY 2761

Query: 785  EFKGKEILRIRSES--NQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQ 836
            +   KE+ +++ +   N++      E  + M  ++   +  + +L   L  +D+
Sbjct: 2762 DASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDE 2815



 Score =  117 bits (292), Expect = 7e-26
 Identities = 224/1032 (21%), Positives = 430/1032 (41%), Gaps = 208/1032 (20%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSF-GQLQVQFE 60
            ++ A  E +   H  E +QL  +A        M +++  ++RK EE   S  G+ QV   
Sbjct: 221  EKDARFETQVRLHEDELLQLVTQADVETE---MQQKLRVLQRKLEEHEESLVGRAQVV-- 275

Query: 61   KDKRLALEDLQAAHRRE---IQELLKSQQDHSASVNKGQEKAEE----LHRMEVESLNKM 113
                L  ++L AA +R     Q+L + + +H+   N  + + EE    L +ME+E   + 
Sbjct: 276  ---DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332

Query: 114  LE--ELRLERKKLIEDYEGKLNKAQSFYERELDTLKR--------------SQLFTAESL 157
            L    L+ E   L+E +E +  +AQ+  E     L++              S   T + L
Sbjct: 333  LSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391

Query: 158  QAS----KEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC--QKLQTAL- 210
            Q++    K++ + L ++   Q     +TI +L+ +LQ    E    L++   Q+ +TA  
Sbjct: 392  QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQ 451

Query: 211  ------------AIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASD 258
                        A+ E N+  LQK++ + +  + ALL    E+E EL A  E+L  Q + 
Sbjct: 452  TSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELE-ELKAENEKLSSQIT- 509

Query: 259  LVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQS----LDEE 314
            L+   +  G  +A +   E++I D+ +++S   E   Q   E  F +   +     L+ +
Sbjct: 510  LLEAQNRTG--EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567

Query: 315  QKQQILELEKKVNEAKRTQQEYYE----RELKNLQSR----------LEE---------- 350
            + Q+ +   K   + KR ++  +E    +E+K ++            LE+          
Sbjct: 568  EAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627

Query: 351  --------EVTQLNEAH-SKTLEELAWKHHMAIEAVHSNAIRDKKKLQM-DLEEQHNKDK 400
                    E  Q +  H S+T EE++  +   +E   +    DK    + D+ + H  + 
Sbjct: 628  EESSLPAVEKEQASTEHQSRTSEEISL-NDAGVELKSTKQDGDKSLSAVPDIGQCHQDEL 686

Query: 401  LNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQ 460
              L+    +L+      +E+ E  L+   +EI +L  ++ + ++   +      +L + +
Sbjct: 687  ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746

Query: 461  ERLQN---ELDLTKDSLKETKDALLNVEGELEQERQQHEETIA----AMKEEEKLKVDKM 513
            ++L +   EL +  +   + K   +N+     Q R  +E   A      ++   L ++  
Sbjct: 747  DQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAK 806

Query: 514  AHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQ-----K 568
            + D++I+  +N         ++++LQ  E      S   QL+++E      + +      
Sbjct: 807  SKDVKIEVLQNEL-------DDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS 859

Query: 569  KVEDL---LNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRH- 624
            KVE+L   L+Q  L    ++  L + +  ++ LQ    ++ Q++T+    + E+  Q + 
Sbjct: 860  KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE 919

Query: 625  ---------KSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGF 675
                     K+LKE   L   +  EE +KEQ   +N +          +  A + S E  
Sbjct: 920  EKFSLGVEIKTLKEQ--LNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE-- 975

Query: 676  RIEMEQELQTLRFELEDEGKAMLASL--RSELNHQHAAAIDLLRHNHHQELAAAKMELER 733
              E++ E   L+ E E   + + A+L  R EL  Q  + ++       +ELA  K E ++
Sbjct: 976  --ELQHEFDLLKKENEQRKRKLQAALINRKELL-QRVSRLE-------EELANLKDESKK 1025

Query: 734  SIDISR---------RQSKEHI--CRITDLQEELRHREHHISELDKEVQHLH-------- 774
             I +S          +++KE+   C  +  QE   + +  ISE + E+QH+         
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085

Query: 775  --ENISALTKE----LEFKGKEILRIRSE--SNQQIRLE--------------------- 805
              E   AL K+    L+ K  +I  +++E   NQ I  +                     
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145

Query: 806  ---------------EMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQL 850
                           E+EEK L  E + E +Q   +L+  LT R  I+KK  E  +  + 
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQK--KLQEALTSRKAILKKAQEKERHLRE 1203

Query: 851  ELVNRETNFNKV 862
            EL  ++ ++N++
Sbjct: 1204 ELKQQKDDYNRL 1215



 Score =  113 bits (283), Expect = 8e-25
 Identities = 189/820 (23%), Positives = 352/820 (42%), Gaps = 101/820 (12%)

Query: 3    QQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLR----SFGQLQVQ 58
            Q  L + E+    ++D QL   +  +++       +E I R+ E  ++    S+ QL+  
Sbjct: 2304 QNELAKLESELKSLKD-QLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD 2362

Query: 59   FEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELR 118
             +  + L     +  + +E Q+++        ++     +  + H  E++ L  +L +  
Sbjct: 2363 LQASRELTSRLHEEINMKE-QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE 2421

Query: 119  LERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAIL 178
             E   L E+ +  ++K     E  L T+K+  +     L +  +  + L+ +        
Sbjct: 2422 EENIVLEEENKKAVDKTNQLMET-LKTIKKENIQQKAQLDSFVKSMSSLQNDRD------ 2474

Query: 179  RKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENN-----VQVLQKQLDDAKEGEMA 233
             + +G  +   Q+ +     +L+K Q +Q A A  ENN     ++ L+  +DD       
Sbjct: 2475 -RIVGDYQ---QLEERHLSIILEKDQLIQEAAA--ENNKLKEEIRGLRSHMDD------- 2521

Query: 234  LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNER 293
            L S++ ++++EL   RE L Q    + +K S    L   Q+ Q    K+LE++ +++ E+
Sbjct: 2522 LNSENAKLDAELIQYREDLNQV---ITIKDSQQKQLLEVQLQQN---KELENKYAKLEEK 2575

Query: 294  LSQLEEERAFLRSKTQSLDEEQKQQILELEK-KVNEAKRTQQEYYERELKNLQSRLEEEV 352
            L + EE    LR    +L EE++    E+E  KV+ ++ T+Q         + +  EE  
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQ---------VTALQEEGT 2626

Query: 353  TQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ 412
              L  A  K  EE   +    + A+ S++ +   +L+ +L     +    + E +++L++
Sbjct: 2627 LGLYHAQLKVKEEEVHR----LSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK 2682

Query: 413  ELENLKE---VLEDKLNTANQEIGHLQDMVRKSEQGL----GSAEGLIASLQD---SQER 462
            EL++L     ++ ++  TA + +  L   + + EQ L       +GL A +Q    S   
Sbjct: 2683 ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS 2742

Query: 463  LQNELDLTKDSLKETK---DALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEI 519
            LQN  D   + L E K   DA L    EL Q ++Q       +  E    + + A  +  
Sbjct: 2743 LQNSRDHANEELDELKRKYDASLK---ELAQLKEQ-----GLLNRERDALLSETAFSMN- 2793

Query: 520  KWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREK--NAARDSWQKKVEDLLNQI 577
               EN      KL ++L L  +E      SQL    ++ +  + A  S Q + + L N++
Sbjct: 2794 STEENSLSHLEKLNQQL-LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL 2852

Query: 578  SLL------KQNLEIQLSQSQTSLQQLQ---AQFTQERQRLTQELEELEEQHQQRHKSLK 628
                     KQ    Q S S   +Q L+   +    +R RL +EL+ L++Q+ Q ++ + 
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT 2912

Query: 629  EAHVLAFQTME-EEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQ----EL 683
            E H L  Q  E ++K K  + ++  L+Q++   L    + H+  ME    E+ +    E 
Sbjct: 2913 ELHPLKAQLQEYQDKTKAFQIMQEELRQEN---LSWQHELHQLRMEKSSWEIHERRMKEQ 2969

Query: 684  QTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSK 743
              +    +D+  + L +L  EL    +    L      Q    A  E   S D S+    
Sbjct: 2970 YLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQ----ASPETSASPDGSQNLVY 3025

Query: 744  EHICRITDLQEELRHREHHISELDKEVQHLHENISALTKE 783
            E     T L + L  +E H  EL   +Q L+ N S L +E
Sbjct: 3026 ETELLRTQLNDSL--KEIHQKEL--RIQQLNSNFSQLLEE 3061



 Score =  110 bits (274), Expect = 8e-24
 Identities = 188/923 (20%), Positives = 397/923 (43%), Gaps = 114/923 (12%)

Query: 6    LTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRL 65
            L E E  +    + Q   +    ++I ++S E +    K E        +Q+QF +   L
Sbjct: 773  LAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL 832

Query: 66   ALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLI 125
             +  LQ+  + +  E+L+  +      +K +E ++ L + E+E + KM ++L LE+K+ +
Sbjct: 833  -IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELE-ITKM-DQLLLEKKRDV 889

Query: 126  EDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK-----EADLRKEFQGQEAILRK 180
            E  +      Q+  E++    + S   T + +Q ++EK     E    KE   Q  +L +
Sbjct: 890  ETLQ------QTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE---QLNLLSR 940

Query: 181  TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQ----VLQKQLDDAKEGEMALLS 236
                 K +++   + +  L     ++  A  I++  +Q    +L+K+ +  K    A L 
Sbjct: 941  AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI 1000

Query: 237  KHKEVESELAAARERL----QQQASDLVLKASHIGMLQATQMTQEVTIKDLESE------ 286
              KE+   ++   E L     +   ++ L  +  G ++  +  +E + K + S+      
Sbjct: 1001 NRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI 1060

Query: 287  --KSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNL 344
              K  ++E+  +L+  R  L  K  +  EEQ Q +++   +  + K  Q +  + E+   
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKLAA--EEQFQALVKQMNQTLQDKTNQIDLLQAEISEN 1118

Query: 345  QSRLEEEVTQLNEAHSKTLEELA----------------WKHHMAIEAVHSNAIRDKKKL 388
            Q+ +++ +T   +A       L                 WK  +  + +     ++K++L
Sbjct: 1119 QAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALE--KEKEQL 1176

Query: 389  QMDLEEQHNKDKLNL---EEDKNQLQQELENLKEV---LEDKLNTANQEIGHLQDMVRKS 442
            Q  L+E     K  L   +E +  L++EL+  K+    L+++ +  ++E  ++ D +R+ 
Sbjct: 1177 QKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1236

Query: 443  E-QGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLN--VEGELEQERQQHEETI 499
            + Q   S +G + S  D QE   +   L +   K T+       +E  L  +   H E  
Sbjct: 1237 QIQVRESIDGKLPST-DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295

Query: 500  AAMK----------EEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMS 549
            +A++          + ++++ +K+  +LE+K +    +   K  E  +LQ + +K+    
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKV--ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353

Query: 550  QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEI----------------------- 586
            + L+    E     +S Q+K+E    QI+ L+   E+                       
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG 1413

Query: 587  QLSQSQTSLQQLQAQFTQER---QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKE 643
            QLS+ + +L ++Q +  ++    + L  +LE   ++H +R K L +  +   +   EE  
Sbjct: 1414 QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQL-QVELCEMKQKPEEIG 1472

Query: 644  KEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRS 703
            +E RA +  +Q+K  A L S K+A +E+       +++EL   R  +E   K+ LA + S
Sbjct: 1473 EESRA-KQQIQRKLQAALISRKEALKENK-----SLQEELSLARGTIERLTKS-LADVES 1525

Query: 704  ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 763
            +++ Q+     +L      +    K+  E    +   QS    C    L+  L       
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCE--SLKLALEGLTEDK 1583

Query: 764  SELDKEVQHLHENISALTKELEFKGKEILR---IRSESNQQIRLEEMEEKYLMRESKPED 820
             +L KE++ L  +  A + E + K KE+ +   I  +S + +  E    ++++   + E 
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643

Query: 821  IQMITELKAMLTERDQIIKKLIE 843
             ++  +L++    + +  K+L E
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQE 1666



 Score =  108 bits (269), Expect = 3e-23
 Identities = 186/900 (20%), Positives = 375/900 (41%), Gaps = 126/900 (14%)

Query: 39  EEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEK 98
           +E   +F    +   Q ++ + +   + L+D+      ++Q+  ++ Q+   + +   +K
Sbjct: 36  QESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKK 95

Query: 99  AEELHRMEVESLNKMLEELRLERKKLI------EDYEGKLNKAQSFYERELDTLKRSQLF 152
            +   + ++ SLNK +EE++ +   ++      E+   K +K+ +  E E++ +K     
Sbjct: 96  LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE 155

Query: 153 TAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL---LDKCQKLQTA 209
             E +   + +    + E   Q +   +    +K +LQ  ++   +L   L + Q  Q A
Sbjct: 156 KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215

Query: 210 LAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESE----LAAARERLQQQASDLVLKASH 265
             +        + Q+    E E+  L    +VE+E    L   + +L++    LV +A  
Sbjct: 216 QQVVREKDARFETQV-RLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274

Query: 266 IGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKK 325
           + +LQ     QE+T    E     ++++L Q+E E   LR+  ++  EE K  + ++E +
Sbjct: 275 VDLLQ-----QELTA--AEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE 327

Query: 326 VNEAK----RTQQEYYE-----RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEA 376
           V E K      Q+E +       +    Q+ LE   + L + H   +EE    H ++++ 
Sbjct: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKT-SHILSLQK 386

Query: 377 VHS------NAIRDK-KKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLE----DKL 425
                    +A++D+  KL  D  EQ  +    +++ ++QLQQ+ + + + L      + 
Sbjct: 387 TGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQH 446

Query: 426 NTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNE---LDLTKDSLKETKDALL 482
            TA+Q      D+  +  Q +   E  IASLQ     L+NE   L L+   L+E K    
Sbjct: 447 ETASQT--SFPDVYNEGTQAV--TEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502

Query: 483 NVEGEL----------EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKL 532
            +  ++          E +R+  E +I  +  +     ++   D+     EN   +  K 
Sbjct: 503 KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV----LENTFSQKHKE 558

Query: 533 REELRLQHEEDKKSAMSQLLQLKDREKNAARDSW--QKKVEDLLNQ-ISLLKQNLEIQ-- 587
              L L+ +E ++      LQL+ +    A      QK+++ +  + I+ +K  + ++  
Sbjct: 559 LSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDT 618

Query: 588 ------LSQSQTSLQQLQAQ--FTQERQRLTQELE------ELEEQHQQRHKSLK----- 628
                 +   ++SL  ++ +   T+ + R ++E+       EL+   Q   KSL      
Sbjct: 619 GQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678

Query: 629 ------EAHVLAFQTMEEEK--EKEQRALENHLQQKHS---------AELQSLKDAHRES 671
                 E   L  Q +E E    K Q   E +L +K            E +   D +  +
Sbjct: 679 GQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738

Query: 672 MEGFRIEMEQEL-QTLRFELEDEGKAMLASL---------RSELNHQHAAAID-LLRHNH 720
                 E +Q L Q     +  E +A +  L         +  L+++   A D LL    
Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798

Query: 721 HQELAAAKME------LERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLH 774
           H     AK +      L+  +D  + Q  E    I  LQ +L+++E  + E  + V+H+ 
Sbjct: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHIS 858

Query: 775 ENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTER 834
             +  L++ L  K  EI ++      Q+ LE+  +   ++++  E  Q +TE+   +TE+
Sbjct: 859 SKVEELSQALSQKELEITKM-----DQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEK 913



 Score =  101 bits (252), Expect = 3e-21
 Identities = 200/1008 (19%), Positives = 414/1008 (41%), Gaps = 198/1008 (19%)

Query: 25   AQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKD------------KRLALEDLQA 72
            ++H +       E+E+I+ K +EK      LQ Q  +             +   +   Q 
Sbjct: 133  SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192

Query: 73   AHRREIQELLKSQQDHSASVNKGQEKAEE----------LHRMEVESL-------NKMLE 115
              + E    L++Q   + +    Q+   E          LH  E+  L        +M +
Sbjct: 193  QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252

Query: 116  ELRLERKKLIEDYEGKLNKAQ--SFYERELDTLKRSQLFTAESLQASKEKEADLRK---- 169
            +LR+ ++KL E  E  + +AQ     ++EL   ++     ++ LQ  + +   LR     
Sbjct: 253  KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET 312

Query: 170  EFQGQEAILRK---TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDD 226
            E +  + +L K    + + K     +Q+E   LL++ ++   A A  E+    L+++   
Sbjct: 313  EREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA 372

Query: 227  AKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESE 286
              E + + +   ++   EL +A + L+ Q S L+   +     QA Q  Q  TI+ LE +
Sbjct: 373  EMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNE----QAVQSAQ--TIQQLEDQ 426

Query: 287  KSRVNERLSQL-------EEERAFLRS-------KTQSLDEEQ----KQQILELEKKVNE 328
              + ++ +SQ        + E A   S        TQ++ EE     +++++ELE +   
Sbjct: 427  LQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGA 486

Query: 329  AKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL 388
               +  E    ELK    +L  ++T L EA ++T E       ++I  + +      ++ 
Sbjct: 487  LLLSSIEL--EELKAENEKLSSQITLL-EAQNRTGEADREVSEISIVDIANKRSSSAEES 543

Query: 389  QMDLEE----QHNKDKLNLEEDKNQLQQELENLKEVLEDK-LNTANQEIGHLQDMVRKSE 443
              D+ E    Q +K+   L  +  + Q+E+  LK  L+ K    A+ E+   ++M +   
Sbjct: 544  GQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEG 603

Query: 444  QGL------------GSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEG-ELEQ 490
            +G+            G    L+ + + S   ++ E   T+   + +++  LN  G EL+ 
Sbjct: 604  EGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKS 663

Query: 491  ERQQHEETIAAM--------KEEEKLK-----VDKMAHDLEIKWTENLRQECSKLREELR 537
             +Q  +++++A+         E E+LK     ++   H  +  + +NL ++  ++    +
Sbjct: 664  TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQ 723

Query: 538  LQHE----------------EDKKSAMSQL----------LQLKDREKNAARDSWQKKVE 571
            L  E                E++   +SQ+           Q+K  E N A    Q++++
Sbjct: 724  LIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLD 783

Query: 572  ------------DLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQ--------ERQRLTQ 611
                        + ++ +S+  ++ ++++   Q  L  +Q QF++        + Q   +
Sbjct: 784  YESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNK 843

Query: 612  ELEELEEQHQQRH-----------KSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHS-- 658
            E E LE   + RH            S KE  +     +  EK+++   L+  +++K    
Sbjct: 844  ESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQV 903

Query: 659  AELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRH 718
             E+          +   +  +  E++TL+ +L    +A  A  + E   +       L+ 
Sbjct: 904  TEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEA--KKEQVEEDNEVSSGLKQ 961

Query: 719  NHHQELAA---AKMELERSIDISRRQS--------------KEHICRITDLQEELRH--- 758
            N+ +   A   +K EL+   D+ ++++              KE + R++ L+EEL +   
Sbjct: 962  NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021

Query: 759  ---REHHISELDK-EVQHLHEN-------ISALTKELEF--------KGKEILRIRSESN 799
               +E  +SE ++ EV+   EN       +++  +E+E         K  E+  IR +  
Sbjct: 1022 ESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLE 1081

Query: 800  QQIRLEEMEEKYL--MRESKPEDIQMITELKAMLTERDQIIKKLIEDN 845
            +++  EE  +  +  M ++  +    I  L+A ++E   II+KLI  N
Sbjct: 1082 EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSN 1129


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  140 bits (353), Expect = 6e-33
 Identities = 180/795 (22%), Positives = 366/795 (46%), Gaps = 147/795 (18%)

Query: 140  ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQM-VQDEAGS 198
            E+E+ T+K     T E L  S+ +  +L ++     ++L++     K +LQ+ VQ E  +
Sbjct: 850  EKEMATMKEDFERTKEELARSEARRKELEEKMV---SLLQE-----KNDLQLQVQSETEN 901

Query: 199  LLD---KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQ 255
            L+D   +C+ L  +  + E  V+ L ++L++ +E    L++K + +E + ++    L++ 
Sbjct: 902  LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS----LKRD 957

Query: 256  ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLR-SKTQSLDEE 314
              DL L  + +   +  +   E  +K+L  E + + E +S+L +E+  L+ +  Q+LD+ 
Sbjct: 958  IDDLELTLTKV---EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDL 1014

Query: 315  QKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAI 374
            Q +     E KVN   +   +  E++  +L+  LE+E                       
Sbjct: 1015 QVE-----EDKVNGLIKINAKL-EQQTDDLEGSLEQE----------------------- 1045

Query: 375  EAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ-------ELENLKEVLEDKLNT 427
            + + ++  R K+KL+ DL+    +  ++LE DK Q+++       EL  L+  ++D+   
Sbjct: 1046 KKLRADLERAKRKLEGDLK-MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH 1104

Query: 428  ANQ---EIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA---- 480
            + Q   +I  LQ  + + E+ + +   L A ++  +  L  EL+   + L+E   A    
Sbjct: 1105 SLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164

Query: 481  ----------LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 530
                         +  +LE+   QHE T A +++++   V ++   ++    + ++Q+  
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN--LQRVKQKLE 1222

Query: 531  KLREELRLQHEEDKKS--AMSQLLQLKDREKNAARDSWQK-KVED-----LLNQISLLKQ 582
            K + EL+++ ++   +  A+S+     +R      D + + K +D     L++ +++ K 
Sbjct: 1223 KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKA 1282

Query: 583  NLEIQ---LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQT-- 637
             L+ Q   LS      + L +Q T+ +Q LTQ+LEEL+ Q ++  K+ K A   A Q+  
Sbjct: 1283 RLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKA-KNAMAHALQSSR 1341

Query: 638  -----MEEEKEKEQRA---LENHLQQKHS-----------------AELQSLK------- 665
                 + E+ E+EQ A   L+  L + +S                  EL+  K       
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401

Query: 666  ---DAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQ 722
               + + E+       +E+  Q L+ E+ED  + +      E +H   A +D  + N  +
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL------ERSHTACATLDKKQRNFDK 1455

Query: 723  ELAAAKMELERS---IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISA 779
             LA  K +L+ S   ++ ++++S+     +  ++         +  L +E ++L E IS 
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515

Query: 780  LTKELEFKGKEI--------LRIRSESNQQIRLEEMEEKYLMRESK-----PEDIQMITE 826
            LT+++   GK +        L  + +S+ Q+ LEE+E      ESK      E  Q+ +E
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE 1575

Query: 827  LKAMLTERDQIIKKL 841
            L   + E+D+ I++L
Sbjct: 1576 LDRKVIEKDEEIEQL 1590



 Score =  130 bits (327), Expect = 6e-30
 Identities = 210/940 (22%), Positives = 398/940 (42%), Gaps = 156/940 (16%)

Query: 10   EAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALED 69
            EA++  ++D+Q+  E   V  ++ ++ ++E+     E  L    +L+   E+ KR    D
Sbjct: 1005 EAHQQTLDDLQV--EEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD 1062

Query: 70   LQAAH---------RREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            L+ +          +++I+E LK +++   S  + +   E++H ++ +   K ++EL+  
Sbjct: 1063 LKMSQESIMDLENDKQQIEEKLK-KKEFELSQLQAKIDDEQVHSLQFQ---KKIKELQAR 1118

Query: 121  RKKLIEDYEG------KLNKAQSFYERELDT----LKRSQLFTAESLQASKEKEADLRKE 170
             ++L E+ E       K+ K +S   REL+     L+ +   T+  ++ +K++EA+ +K 
Sbjct: 1119 IEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKM 1178

Query: 171  FQG-QEAILRK--TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDA 227
             +  +EA L+   T   L+ +      E G  +D  Q+++  L   E     L+ ++DD 
Sbjct: 1179 RRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKL---EKEKSELKMEIDDM 1235

Query: 228  KEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEK 287
                 AL      +E       ++  +              ++A    Q   I DL  +K
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSE--------------IKAKDEQQTQLIHDLNMQK 1281

Query: 288  SRV---NERLSQLEEERAFLRSK--------TQSLDEEQKQQILELEKKVNEAKRTQQEY 336
            +R+   N  LS   EE+  L S+        TQ L+E ++Q   E + K   A   Q   
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSR 1341

Query: 337  YERELKNLQSRLEEEV-TQLNEAHSKTLEELA-WKHHMAIEAVHSNAIRD--KKKLQMDL 392
            ++ +L   Q   E+E   +L  A SK   E+A W+     +A+      +  KKKL   L
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401

Query: 393  EE-QHNKDKLN-----LEEDKNQLQQELENLKEVLEDKLN---TANQEIGHLQDMVRKSE 443
            +E + N +  N     LE+ K +LQ E+E+L   LE       T +++  +   ++ + +
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461

Query: 444  QGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDAL-------LNVEGELEQERQQHE 496
            Q L  ++  + + Q     L  EL   +++ +E  D L        N++ E+    +Q  
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521

Query: 497  ETIAAMKEEEKLK--VDKMAHDLEIKWTE---NLRQECSK-LREELRLQH---EEDKK-- 545
            ET   ++E EK K  V++   DL++   E   +L  E SK LR +L L     E D+K  
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI 1581

Query: 546  -----------------SAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQL 588
                              A+  +L  + R +N A    +KK+E  LN++ +   +   Q+
Sbjct: 1582 EKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL-RLKKKMEGDLNEMEIQLGHSNRQM 1640

Query: 589  SQSQTSLQQLQAQFTQERQRLTQEL---EELEEQH---QQRH----KSLKEAHVLAFQTM 638
            +++Q  L+ +Q Q    +  L   L   E+L+EQ    ++R+    + L+E  V   QT 
Sbjct: 1641 AETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTE 1700

Query: 639  EEEKEKEQRALE--NHLQQKHS--AELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEG 694
               +  EQ  L+  + +Q  HS    L + K      +   + E+E  +Q  R   E   
Sbjct: 1701 RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAK 1760

Query: 695  KAML--ASLRSELNHQHAAAIDLLRHNHH---------------------------QELA 725
            KA+   A +  EL  +   +  L R   +                           Q+L 
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820

Query: 726  AAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELE 785
                ELE  +D+ +++  E +      + +++   +   E  K +  L + +  L  +++
Sbjct: 1821 NRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVK 1880

Query: 786  FKGKEILRIRSESNQQI--------RLEEMEEKYLMRESK 817
               ++      ++N Q+         LEE  E+  + ES+
Sbjct: 1881 SYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQ 1920



 Score =  125 bits (313), Expect = 3e-28
 Identities = 187/899 (20%), Positives = 384/899 (42%), Gaps = 105/899 (11%)

Query: 39   EEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEK 98
            E  R++ EEK+ S  Q +   +   +   E+L  A  R  + L+KS+    A V +  E+
Sbjct: 871  EARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER-CEGLIKSKILLEAKVKELTER 929

Query: 99   AEELHRMEVESLNKM--LEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAES 156
             EE   M  E + K   LE+     K+ I+D E  L K     E+E    +      +E 
Sbjct: 930  LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKV----EKEKHATENKVKNLSEE 985

Query: 157  LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENN 216
            + A +E  + L KE +  +   ++T+     +LQ+ +D+   L+    KL+      E +
Sbjct: 986  MTALEENISKLTKEKKSLQEAHQQTLD----DLQVEEDKVNGLIKINAKLEQQTDDLEGS 1041

Query: 217  VQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQ 276
            ++  +K   D +  +  L    K  +  +       QQ    L  K   +  LQA    +
Sbjct: 1042 LEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDE 1101

Query: 277  EVTIKDLESEKSRVNERLSQLEEE---RAFLRSKTQSLDEEQKQQILELEKKVNEA---- 329
            +V     + +   +  R+ +LEEE      LR+K +    +  +++ E+ +++ EA    
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161

Query: 330  -------KRTQQEYYE--RELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSN 380
                   K+ + E+ +  R+L+    + E     L +  + ++ EL  +    ++ V   
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELG-EQIDNLQRVKQK 1220

Query: 381  AIRDKKKLQMDLE------EQHNKDKLNLEEDKNQLQQELENLK-------EVLED---- 423
              ++K +L+M+++      E  +K K N+E     ++ +   +K       +++ D    
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280

Query: 424  --KLNTANQEIGH----------------------LQDMVRKSEQGLGSAEGLIASLQDS 459
              +L T N E+ H                      L+++ R+ E+   +   +  +LQ S
Sbjct: 1281 KARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSS 1340

Query: 460  Q---ERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHD 516
            +   + L+ + +  +++  E + AL     E+ Q R ++E       EE +    K+A  
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400

Query: 517  LE--IKWTENLRQECSKL-REELRLQHEE-------DKKSAMSQLLQLKDREKNAARDSW 566
            L+   + TE    +C+ L + + RLQ E        ++       L  K R  +     W
Sbjct: 1401 LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEW 1460

Query: 567  QKKVEDLLNQISLLK---QNLEIQLSQSQTSLQQLQAQ---FTQERQRLTQELEELEEQH 620
            ++K+++   ++   +   ++L  +L + + + +++  Q     +E + L +E+ +L EQ 
Sbjct: 1461 KQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI 1520

Query: 621  QQRHKSLKEAHVLAFQTMEEEKEKEQRAL---ENHLQQKHSAELQSLKDAHRESMEGFR- 676
             +  K+L+EA     + +E+EK   Q AL   E  L+ + S  L+   +  +   E  R 
Sbjct: 1521 AETGKNLQEAEKTK-KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRK 1579

Query: 677  -IEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSI 735
             IE ++E++ L+   +   +A+ + L +E+  ++    D LR     E    +ME++  +
Sbjct: 1580 VIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN----DALRLKKKMEGDLNEMEIQ--L 1633

Query: 736  DISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIR 795
              S RQ  E    +  +Q +L+  + H+ +  +  + L E ++ + +      +E+  ++
Sbjct: 1634 GHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMK 1693

Query: 796  SESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVN 854
                Q  R   + E+ L+  S  + +Q++      L       KKL  D    Q E+ N
Sbjct: 1694 VALEQTERTRRLSEQELLDAS--DRVQLLHSQNTSLINTK---KKLEADIAQCQAEVEN 1747



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 62/275 (22%), Positives = 119/275 (43%), Gaps = 53/275 (19%)

Query: 600  AQFTQERQRLTQELEELEEQ---HQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK 656
            A+  +E   + ++ E  +E+    + R K L+E  V   Q             +N LQ +
Sbjct: 847  AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQE------------KNDLQLQ 894

Query: 657  HSAELQSLKDAHRESMEGF---RIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAI 713
              +E ++L DA  E  EG    +I +E +++ L   LE+E          E+N       
Sbjct: 895  VQSETENLMDAE-ERCEGLIKSKILLEAKVKELTERLEEE---------EEMN------- 937

Query: 714  DLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHL 773
                     EL A K  LE      +R   +    +T +++E    E+ +  L +E+  L
Sbjct: 938  --------SELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTAL 989

Query: 774  HENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMR-----ESKPEDIQ-MITEL 827
             ENIS LTKE     K +     ++   +++EE +   L++     E + +D++  + + 
Sbjct: 990  EENISKLTKE----KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE 1045

Query: 828  KAMLTERDQIIKKLIEDNKFYQLELVNRETNFNKV 862
            K +  + ++  +KL  D K  Q  +++ E +  ++
Sbjct: 1046 KKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  139 bits (350), Expect = 1e-32
 Identities = 205/910 (22%), Positives = 385/910 (42%), Gaps = 126/910 (13%)

Query: 19   MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 72
            +Q+  + + +Q      ++ +E ++K E +L+   Q   Q  ++K L  E LQA      
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 73   ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 116
                      A ++E++E+L   +   A + + +++ ++L         ++  L + LEE
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 117  LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 156
                R+KL                    ++D   KL+K +   E  +  L         +
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1014

Query: 157  LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 215
            L   +EK  +L K     E+++ +   +LK E +  Q+     L+K  +KL+   +    
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1069

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 272
             +  LQ Q+ + K   M L  K +E+++ LA   + + Q+ + L        HI  LQ  
Sbjct: 1070 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126

Query: 273  QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 329
              ++       E +K  + E L  L+ E       T   Q L  +++Q++  L+K ++E 
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186

Query: 330  KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 388
             R+  E   +E++   ++  EE+T+  E   +    L  K+   +E  +++   + + L 
Sbjct: 1187 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1244

Query: 389  QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 443
            Q   E +H K KL  +  + Q +  + E  +  L DK++    E+  +  M+ ++E    
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304

Query: 444  QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 494
            +       L + LQD+QE LQ E      +      L+E +++L   L+ E E +Q  ++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 495  HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 554
            H  T+     + K K+   A  +E    E  ++   K  E L  Q+EE K +A  +L   
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1418

Query: 555  KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 612
             ++ KN  +      V DL NQ  L+   +  + +  Q     + + +++  ER R   E
Sbjct: 1419 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477

Query: 613  LEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAH--RE 670
              E E +     ++L+EA        +EE E+  + L+  ++   S++    K+ H   +
Sbjct: 1478 AREKETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532

Query: 671  SMEGFRIEMEQELQTLRFELEDEGKAML-ASLRSELNHQHAAAIDLLRHNHHQELAAAKM 729
            S      +ME E++T   ELEDE +A   A LR E+N Q                 A K 
Sbjct: 1533 SKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQ-----------------ALKG 1574

Query: 730  ELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKE---VQHLHENISALTKELEF 786
            + ER +     Q++E   +   LQ +L   E  + +  K+        + +    K+LE 
Sbjct: 1575 QFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 787  KGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK 846
            +    ++ R E+ +Q+R  + + K   RE +        E+ A   E ++  K L  D  
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLM 1690

Query: 847  FYQLELVNRE 856
              Q +L   E
Sbjct: 1691 QLQEDLAAAE 1700



 Score =  130 bits (327), Expect = 6e-30
 Identities = 184/876 (21%), Positives = 372/876 (42%), Gaps = 141/876 (16%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 95
            RE+E      +E L S    + + EK KR   E+L+A         LK++ + +      
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------LKTELEDTLDSTAT 1164

Query: 96   QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 155
            Q++       EV  L K L+E     +  +++   K  +A      +L+  KR++    +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 156  SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAEN 215
            + Q  +++ ADL  E         + +G+ K E++           K +KL       E 
Sbjct: 1225 NKQTLEKENADLAGEL--------RVLGQAKQEVE----------HKKKKL-------EA 1259

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMT 275
             VQ LQ +  D +     L  K  ++++E+ +    L +     +  A  +  L +    
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 276  QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 335
             +  +++   +K  V+ +L QLEEER  L+ +   LDE       E+E K N        
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDE-------EMEAKQN-------- 1361

Query: 336  YYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQ 395
              ER +  L  +L +          K L++ A      +EA+     R +K+++ +L +Q
Sbjct: 1362 -LERHISTLNIQLSDS--------KKKLQDFA----STVEALEEGKKRFQKEIE-NLTQQ 1407

Query: 396  HNKDKL---NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGL 452
            + +       LE+ KN+LQQEL++L   L+++     Q + +L+   RK +Q L   + +
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ----RQLVSNLEKKQRKFDQLLAEEKNI 1463

Query: 453  IASLQDSQERLQ------------------------NELDLTKDSLKETKDALLNVE--- 485
             +   D ++R +                         EL+ T   LK   + L++ +   
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523

Query: 486  GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS------KLREELRL- 538
            G+   E ++ +  +    EE K +++++  +L+      LR E +      +   +L+  
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583

Query: 539  --QHEEDKKSAMSQLLQLK-----DREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQS 591
              Q+EE ++    QL + +     +R++ A   + +KK+E  L  + L   +      ++
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 592  QTSLQQLQAQ---FTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRA 648
               L++LQAQ   F +E +      +E+    ++  K  K       Q  E+    E+  
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 649  LENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEG---KAMLASLRSEL 705
             +  L+++  AE  +   + R +++  +  +E  +  L  ELE+E    +AM   +R   
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763

Query: 706  NHQHAAAIDL-LRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR----- 759
                  + +L    +  Q+  +A+ +LE       RQ+KE   ++ +++  ++ +     
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLE-------RQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 760  ---EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRES 816
               E  I++L+++V+       A TK L+ K K++  I  +   +    +M E+Y  +E 
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE---RKMAEQY--KEQ 1871

Query: 817  KPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLEL 852
              +    + +LK  L E ++  +++  + +  Q EL
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907



 Score =  105 bits (261), Expect = 3e-22
 Identities = 117/517 (22%), Positives = 244/517 (47%), Gaps = 60/517 (11%)

Query: 385  KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 444
            K  LQ+  +E+  + K +  +   + QQ+ EN  + LE K +   +E   LQ+ ++   +
Sbjct: 842  KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 445  GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 504
                AE +   L   ++ L+  L   +  L+E +D    ++ E ++  QQ  +    ++E
Sbjct: 902  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 505  EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 547
            EE    KL+++K+  + +IK  E+    +  + +KL +E +L  E          +++  
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 548  MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 605
               L +LK++ ++  +  +   KK E    ++  LK+ LE   S     +  LQAQ  + 
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081

Query: 606  RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 656
            + +L ++ EE       L+++  Q++ +LK+   L      ++E+ + E+ A     +QK
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 657  H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 708
                 EL++LK    ++++        R + EQE+  L+  L++E ++  A ++ E+  +
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1200

Query: 709  HAAAIDLLRHNHHQ------ELAAAKMELER-SIDIS--------RRQSKEH-----ICR 748
            HA A++ L     Q       L   K  LE+ + D++         +Q  EH       +
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260

Query: 749  ITDLQEELRHREHHISELDKEVQHLHENISALTKEL-EFKGKEILRIRSESNQQIRLEEM 807
            + +LQ +    E   +EL+ +V  L   + ++T  L E +GK I   +  ++   +L++ 
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 808  EEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIED 844
            +E  L++E   + + + T+L+ +  ER+ +  +L E+
Sbjct: 1321 QE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 51/233 (21%), Positives = 98/233 (42%), Gaps = 27/233 (11%)

Query: 37   EVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQ 96
            E EE+  +    L     LQ     D++  LE   A    E++E   + +  S  V K  
Sbjct: 1709 EKEELAEELASSLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763

Query: 97   EKAEELHR---------MEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK 147
            ++AE+L            + ES  + LE    E +  + + EG +   +S ++  +  L+
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALE 1820

Query: 148  RSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMV-----QDEAGSLLDK 202
                   E ++    ++    K  + ++  L++ + +++ E +M      Q E G+   K
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880

Query: 203  CQKLQTALAIAEN-----NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARE 250
              K Q   A  E+     N + LQ++LD+A E   A+  +   ++S+L    E
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933



 Score = 34.3 bits (77), Expect = 0.58
 Identities = 28/147 (19%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQF-E 60
            +QQ   + +  + ++ +M+   +++    I  +  ++ ++  + E++ R          +
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            KDK+L    LQ    R++ E  K Q +      KG  + ++L R ++E   +  + +   
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAE------KGNARVKQLKR-QLEEAEEESQRINAN 1899

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLK 147
            R+KL  + + +  ++     RE++ LK
Sbjct: 1900 RRKLQRELD-EATESNEAMGREVNALK 1925


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  139 bits (350), Expect = 1e-32
 Identities = 205/910 (22%), Positives = 385/910 (42%), Gaps = 126/910 (13%)

Query: 19   MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 72
            +Q+  + + +Q      ++ +E ++K E +L+   Q   Q  ++K L  E LQA      
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 73   ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 116
                      A ++E++E+L   +   A + + +++ ++L         ++  L + LEE
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 117  LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 156
                R+KL                    ++D   KL+K +   E  +  L         +
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1021

Query: 157  LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 215
            L   +EK  +L K     E+++ +   +LK E +  Q+     L+K  +KL+   +    
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1076

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 272
             +  LQ Q+ + K   M L  K +E+++ LA   + + Q+ + L        HI  LQ  
Sbjct: 1077 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133

Query: 273  QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 329
              ++       E +K  + E L  L+ E       T   Q L  +++Q++  L+K ++E 
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193

Query: 330  KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 388
             R+  E   +E++   ++  EE+T+  E   +    L  K+   +E  +++   + + L 
Sbjct: 1194 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1251

Query: 389  QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 443
            Q   E +H K KL  +  + Q +  + E  +  L DK++    E+  +  M+ ++E    
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311

Query: 444  QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 494
            +       L + LQD+QE LQ E      +      L+E +++L   L+ E E +Q  ++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 495  HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 554
            H  T+     + K K+   A  +E    E  ++   K  E L  Q+EE K +A  +L   
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1425

Query: 555  KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 612
             ++ KN  +      V DL NQ  L+   +  + +  Q     + + +++  ER R   E
Sbjct: 1426 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484

Query: 613  LEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAH--RE 670
              E E +     ++L+EA        +EE E+  + L+  ++   S++    K+ H   +
Sbjct: 1485 AREKETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539

Query: 671  SMEGFRIEMEQELQTLRFELEDEGKAML-ASLRSELNHQHAAAIDLLRHNHHQELAAAKM 729
            S      +ME E++T   ELEDE +A   A LR E+N Q                 A K 
Sbjct: 1540 SKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQ-----------------ALKG 1581

Query: 730  ELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKE---VQHLHENISALTKELEF 786
            + ER +     Q++E   +   LQ +L   E  + +  K+        + +    K+LE 
Sbjct: 1582 QFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 787  KGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK 846
            +    ++ R E+ +Q+R  + + K   RE +        E+ A   E ++  K L  D  
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLM 1697

Query: 847  FYQLELVNRE 856
              Q +L   E
Sbjct: 1698 QLQEDLAAAE 1707



 Score =  130 bits (327), Expect = 6e-30
 Identities = 184/876 (21%), Positives = 372/876 (42%), Gaps = 141/876 (16%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 95
            RE+E      +E L S    + + EK KR   E+L+A         LK++ + +      
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------LKTELEDTLDSTAT 1171

Query: 96   QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 155
            Q++       EV  L K L+E     +  +++   K  +A      +L+  KR++    +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 156  SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAEN 215
            + Q  +++ ADL  E         + +G+ K E++           K +KL       E 
Sbjct: 1232 NKQTLEKENADLAGEL--------RVLGQAKQEVE----------HKKKKL-------EA 1266

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMT 275
             VQ LQ +  D +     L  K  ++++E+ +    L +     +  A  +  L +    
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 276  QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 335
             +  +++   +K  V+ +L QLEEER  L+ +   LDE       E+E K N        
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDE-------EMEAKQN-------- 1368

Query: 336  YYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQ 395
              ER +  L  +L +          K L++ A      +EA+     R +K+++ +L +Q
Sbjct: 1369 -LERHISTLNIQLSDS--------KKKLQDFA----STVEALEEGKKRFQKEIE-NLTQQ 1414

Query: 396  HNKDKL---NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGL 452
            + +       LE+ KN+LQQEL++L   L+++     Q + +L+   RK +Q L   + +
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ----RQLVSNLEKKQRKFDQLLAEEKNI 1470

Query: 453  IASLQDSQERLQ------------------------NELDLTKDSLKETKDALLNVE--- 485
             +   D ++R +                         EL+ T   LK   + L++ +   
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530

Query: 486  GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS------KLREELRL- 538
            G+   E ++ +  +    EE K +++++  +L+      LR E +      +   +L+  
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 539  --QHEEDKKSAMSQLLQLK-----DREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQS 591
              Q+EE ++    QL + +     +R++ A   + +KK+E  L  + L   +      ++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 592  QTSLQQLQAQ---FTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRA 648
               L++LQAQ   F +E +      +E+    ++  K  K       Q  E+    E+  
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 649  LENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEG---KAMLASLRSEL 705
             +  L+++  AE  +   + R +++  +  +E  +  L  ELE+E    +AM   +R   
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770

Query: 706  NHQHAAAIDL-LRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR----- 759
                  + +L    +  Q+  +A+ +LE       RQ+KE   ++ +++  ++ +     
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLE-------RQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 760  ---EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRES 816
               E  I++L+++V+       A TK L+ K K++  I  +   +    +M E+Y  +E 
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE---RKMAEQY--KEQ 1878

Query: 817  KPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLEL 852
              +    + +LK  L E ++  +++  + +  Q EL
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914



 Score =  105 bits (261), Expect = 3e-22
 Identities = 117/517 (22%), Positives = 244/517 (47%), Gaps = 60/517 (11%)

Query: 385  KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 444
            K  LQ+  +E+  + K +  +   + QQ+ EN  + LE K +   +E   LQ+ ++   +
Sbjct: 849  KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 445  GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 504
                AE +   L   ++ L+  L   +  L+E +D    ++ E ++  QQ  +    ++E
Sbjct: 909  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 505  EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 547
            EE    KL+++K+  + +IK  E+    +  + +KL +E +L  E          +++  
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 548  MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 605
               L +LK++ ++  +  +   KK E    ++  LK+ LE   S     +  LQAQ  + 
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088

Query: 606  RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 656
            + +L ++ EE       L+++  Q++ +LK+   L      ++E+ + E+ A     +QK
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 657  H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 708
                 EL++LK    ++++        R + EQE+  L+  L++E ++  A ++ E+  +
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1207

Query: 709  HAAAIDLLRHNHHQ------ELAAAKMELER-SIDIS--------RRQSKEH-----ICR 748
            HA A++ L     Q       L   K  LE+ + D++         +Q  EH       +
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267

Query: 749  ITDLQEELRHREHHISELDKEVQHLHENISALTKEL-EFKGKEILRIRSESNQQIRLEEM 807
            + +LQ +    E   +EL+ +V  L   + ++T  L E +GK I   +  ++   +L++ 
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 808  EEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIED 844
            +E  L++E   + + + T+L+ +  ER+ +  +L E+
Sbjct: 1328 QE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 51/233 (21%), Positives = 98/233 (42%), Gaps = 27/233 (11%)

Query: 37   EVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQ 96
            E EE+  +    L     LQ     D++  LE   A    E++E   + +  S  V K  
Sbjct: 1716 EKEELAEELASSLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770

Query: 97   EKAEELHR---------MEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK 147
            ++AE+L            + ES  + LE    E +  + + EG +   +S ++  +  L+
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALE 1827

Query: 148  RSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMV-----QDEAGSLLDK 202
                   E ++    ++    K  + ++  L++ + +++ E +M      Q E G+   K
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887

Query: 203  CQKLQTALAIAEN-----NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARE 250
              K Q   A  E+     N + LQ++LD+A E   A+  +   ++S+L    E
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940



 Score = 34.3 bits (77), Expect = 0.58
 Identities = 28/147 (19%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQF-E 60
            +QQ   + +  + ++ +M+   +++    I  +  ++ ++  + E++ R          +
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            KDK+L    LQ    R++ E  K Q +      KG  + ++L R ++E   +  + +   
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAE------KGNARVKQLKR-QLEEAEEESQRINAN 1906

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLK 147
            R+KL  + + +  ++     RE++ LK
Sbjct: 1907 RRKLQRELD-EATESNEAMGREVNALK 1932


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  139 bits (350), Expect = 1e-32
 Identities = 205/910 (22%), Positives = 385/910 (42%), Gaps = 126/910 (13%)

Query: 19   MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 72
            +Q+  + + +Q      ++ +E ++K E +L+   Q   Q  ++K L  E LQA      
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911

Query: 73   ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 116
                      A ++E++E+L   +   A + + +++ ++L         ++  L + LEE
Sbjct: 912  EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 117  LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 156
                R+KL                    ++D   KL+K +   E  +  L         +
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1021

Query: 157  LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 215
            L   +EK  +L K     E+++ +   +LK E +  Q+     L+K  +KL+   +    
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1076

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 272
             +  LQ Q+ + K   M L  K +E+++ LA   + + Q+ + L        HI  LQ  
Sbjct: 1077 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133

Query: 273  QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 329
              ++       E +K  + E L  L+ E       T   Q L  +++Q++  L+K ++E 
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193

Query: 330  KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 388
             R+  E   +E++   ++  EE+T+  E   +    L  K+   +E  +++   + + L 
Sbjct: 1194 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1251

Query: 389  QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 443
            Q   E +H K KL  +  + Q +  + E  +  L DK++    E+  +  M+ ++E    
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311

Query: 444  QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 494
            +       L + LQD+QE LQ E      +      L+E +++L   L+ E E +Q  ++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 495  HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 554
            H  T+     + K K+   A  +E    E  ++   K  E L  Q+EE K +A  +L   
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1425

Query: 555  KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 612
             ++ KN  +      V DL NQ  L+   +  + +  Q     + + +++  ER R   E
Sbjct: 1426 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1484

Query: 613  LEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAH--RE 670
              E E +     ++L+EA        +EE E+  + L+  ++   S++    K+ H   +
Sbjct: 1485 AREKETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539

Query: 671  SMEGFRIEMEQELQTLRFELEDEGKAML-ASLRSELNHQHAAAIDLLRHNHHQELAAAKM 729
            S      +ME E++T   ELEDE +A   A LR E+N Q                 A K 
Sbjct: 1540 SKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQ-----------------ALKG 1581

Query: 730  ELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKE---VQHLHENISALTKELEF 786
            + ER +     Q++E   +   LQ +L   E  + +  K+        + +    K+LE 
Sbjct: 1582 QFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 787  KGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK 846
            +    ++ R E+ +Q+R  + + K   RE +        E+ A   E ++  K L  D  
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLM 1697

Query: 847  FYQLELVNRE 856
              Q +L   E
Sbjct: 1698 QLQEDLAAAE 1707



 Score =  130 bits (327), Expect = 6e-30
 Identities = 184/876 (21%), Positives = 372/876 (42%), Gaps = 141/876 (16%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 95
            RE+E      +E L S    + + EK KR   E+L+A         LK++ + +      
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------LKTELEDTLDSTAT 1171

Query: 96   QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 155
            Q++       EV  L K L+E     +  +++   K  +A      +L+  KR++    +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 156  SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAEN 215
            + Q  +++ ADL  E         + +G+ K E++           K +KL       E 
Sbjct: 1232 NKQTLEKENADLAGEL--------RVLGQAKQEVE----------HKKKKL-------EA 1266

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMT 275
             VQ LQ +  D +     L  K  ++++E+ +    L +     +  A  +  L +    
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

Query: 276  QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 335
             +  +++   +K  V+ +L QLEEER  L+ +   LDE       E+E K N        
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDE-------EMEAKQN-------- 1368

Query: 336  YYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQ 395
              ER +  L  +L +          K L++ A      +EA+     R +K+++ +L +Q
Sbjct: 1369 -LERHISTLNIQLSDS--------KKKLQDFA----STVEALEEGKKRFQKEIE-NLTQQ 1414

Query: 396  HNKDKL---NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGL 452
            + +       LE+ KN+LQQEL++L   L+++     Q + +L+   RK +Q L   + +
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ----RQLVSNLEKKQRKFDQLLAEEKNI 1470

Query: 453  IASLQDSQERLQ------------------------NELDLTKDSLKETKDALLNVE--- 485
             +   D ++R +                         EL+ T   LK   + L++ +   
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530

Query: 486  GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS------KLREELRL- 538
            G+   E ++ +  +    EE K +++++  +L+      LR E +      +   +L+  
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590

Query: 539  --QHEEDKKSAMSQLLQLK-----DREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQS 591
              Q+EE ++    QL + +     +R++ A   + +KK+E  L  + L   +      ++
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1650

Query: 592  QTSLQQLQAQ---FTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRA 648
               L++LQAQ   F +E +      +E+    ++  K  K       Q  E+    E+  
Sbjct: 1651 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710

Query: 649  LENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEG---KAMLASLRSEL 705
             +  L+++  AE  +   + R +++  +  +E  +  L  ELE+E    +AM   +R   
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770

Query: 706  NHQHAAAIDL-LRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR----- 759
                  + +L    +  Q+  +A+ +LE       RQ+KE   ++ +++  ++ +     
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLE-------RQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 760  ---EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRES 816
               E  I++L+++V+       A TK L+ K K++  I  +   +    +M E+Y  +E 
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE---RKMAEQY--KEQ 1878

Query: 817  KPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLEL 852
              +    + +LK  L E ++  +++  + +  Q EL
Sbjct: 1879 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914



 Score =  105 bits (261), Expect = 3e-22
 Identities = 117/517 (22%), Positives = 244/517 (47%), Gaps = 60/517 (11%)

Query: 385  KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 444
            K  LQ+  +E+  + K +  +   + QQ+ EN  + LE K +   +E   LQ+ ++   +
Sbjct: 849  KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 445  GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 504
                AE +   L   ++ L+  L   +  L+E +D    ++ E ++  QQ  +    ++E
Sbjct: 909  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 505  EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 547
            EE    KL+++K+  + +IK  E+    +  + +KL +E +L  E          +++  
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 548  MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 605
               L +LK++ ++  +  +   KK E    ++  LK+ LE   S     +  LQAQ  + 
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088

Query: 606  RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 656
            + +L ++ EE       L+++  Q++ +LK+   L      ++E+ + E+ A     +QK
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148

Query: 657  H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 708
                 EL++LK    ++++        R + EQE+  L+  L++E ++  A ++ E+  +
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1207

Query: 709  HAAAIDLLRHNHHQ------ELAAAKMELER-SIDIS--------RRQSKEH-----ICR 748
            HA A++ L     Q       L   K  LE+ + D++         +Q  EH       +
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267

Query: 749  ITDLQEELRHREHHISELDKEVQHLHENISALTKEL-EFKGKEILRIRSESNQQIRLEEM 807
            + +LQ +    E   +EL+ +V  L   + ++T  L E +GK I   +  ++   +L++ 
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327

Query: 808  EEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIED 844
            +E  L++E   + + + T+L+ +  ER+ +  +L E+
Sbjct: 1328 QE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362



 Score = 38.5 bits (88), Expect = 0.031
 Identities = 50/228 (21%), Positives = 97/228 (42%), Gaps = 27/228 (11%)

Query: 37   EVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQ 96
            E EE+  +    L     LQ     D++  LE   A    E++E   + +  S  V K  
Sbjct: 1716 EKEELAEELASSLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770

Query: 97   EKAEELHR---------MEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK 147
            ++AE+L            + ES  + LE    E +  + + EG +   +S ++  +  L+
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALE 1827

Query: 148  RSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMV-----QDEAGSLLDK 202
                   E ++    ++    K  + ++  L++ + +++ E +M      Q E G+   K
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887

Query: 203  CQKLQTALAIAEN-----NVQVLQKQLDDAKEGEMALLSKHKEVESEL 245
              K Q   A  E+     N + LQ++LD+A E   A+  +   ++S+L
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935



 Score = 34.3 bits (77), Expect = 0.58
 Identities = 28/147 (19%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQF-E 60
            +QQ   + +  + ++ +M+   +++    I  +  ++ ++  + E++ R          +
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            KDK+L    LQ    R++ E  K Q +      KG  + ++L R ++E   +  + +   
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAE------KGNARVKQLKR-QLEEAEEESQRINAN 1906

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLK 147
            R+KL  + + +  ++     RE++ LK
Sbjct: 1907 RRKLQRELD-EATESNEAMGREVNALK 1932


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  139 bits (350), Expect = 1e-32
 Identities = 205/910 (22%), Positives = 385/910 (42%), Gaps = 126/910 (13%)

Query: 19   MQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQA------ 72
            +Q+  + + +Q      ++ +E ++K E +L+   Q   Q  ++K L  E LQA      
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904

Query: 73   ----------AHRREIQELLKSQQDHSASVNKGQEKAEELH------RMEVESLNKMLEE 116
                      A ++E++E+L   +   A + + +++ ++L         ++  L + LEE
Sbjct: 905  EAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 117  LRLERKKL--------------------IEDYEGKLNKAQSFYERELDTLKRSQLFTAES 156
                R+KL                    ++D   KL+K +   E  +  L         +
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-------TTN 1014

Query: 157  LQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKC-QKLQTALAIAEN 215
            L   +EK  +L K     E+++ +   +LK E +  Q+     L+K  +KL+   +    
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-----LEKLKRKLEGDASDFHE 1069

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVL---KASHIGMLQAT 272
             +  LQ Q+ + K   M L  K +E+++ LA   + + Q+ + L        HI  LQ  
Sbjct: 1070 QIADLQAQIAELK---MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126

Query: 273  QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT---QSLDEEQKQQILELEKKVNEA 329
              ++       E +K  + E L  L+ E       T   Q L  +++Q++  L+K ++E 
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186

Query: 330  KRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKL- 388
             R+  E   +E++   ++  EE+T+  E   +    L  K+   +E  +++   + + L 
Sbjct: 1187 TRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD-KNKQTLEKENADLAGELRVLG 1244

Query: 389  QMDLEEQHNKDKLNLEEDKNQLQ-QELENLKEVLEDKLNTANQEIGHLQDMVRKSE---- 443
            Q   E +H K KL  +  + Q +  + E  +  L DK++    E+  +  M+ ++E    
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304

Query: 444  QGLGSAEGLIASLQDSQERLQNE------LDLTKDSLKETKDAL---LNVEGELEQERQQ 494
            +       L + LQD+QE LQ E      +      L+E +++L   L+ E E +Q  ++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 495  HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQL 554
            H  T+     + K K+   A  +E    E  ++   K  E L  Q+EE K +A  +L   
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEA--LEEGKKRFQKEIENLTQQYEE-KAAAYDKL--- 1418

Query: 555  KDREKNAARDSWQKKVEDLLNQISLLK--QNLEIQLSQSQTSLQQLQAQFTQERQRLTQE 612
             ++ KN  +      V DL NQ  L+   +  + +  Q     + + +++  ER R   E
Sbjct: 1419 -EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE 1477

Query: 613  LEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAH--RE 670
              E E +     ++L+EA        +EE E+  + L+  ++   S++    K+ H   +
Sbjct: 1478 AREKETKALSLARALEEA-----LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532

Query: 671  SMEGFRIEMEQELQTLRFELEDEGKAML-ASLRSELNHQHAAAIDLLRHNHHQELAAAKM 729
            S      +ME E++T   ELEDE +A   A LR E+N Q                 A K 
Sbjct: 1533 SKRALETQME-EMKTQLEELEDELQATEDAKLRLEVNMQ-----------------ALKG 1574

Query: 730  ELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKE---VQHLHENISALTKELEF 786
            + ER +     Q++E   +   LQ +L   E  + +  K+        + +    K+LE 
Sbjct: 1575 QFERDLQARDEQNEE---KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 787  KGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNK 846
            +    ++ R E+ +Q+R  + + K   RE +        E+ A   E ++  K L  D  
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLM 1690

Query: 847  FYQLELVNRE 856
              Q +L   E
Sbjct: 1691 QLQEDLAAAE 1700



 Score =  130 bits (327), Expect = 6e-30
 Identities = 184/876 (21%), Positives = 372/876 (42%), Gaps = 141/876 (16%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKG 95
            RE+E      +E L S    + + EK KR   E+L+A         LK++ + +      
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------LKTELEDTLDSTAT 1164

Query: 96   QEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAE 155
            Q++       EV  L K L+E     +  +++   K  +A      +L+  KR++    +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 156  SLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAEN 215
            + Q  +++ ADL  E         + +G+ K E++           K +KL       E 
Sbjct: 1225 NKQTLEKENADLAGEL--------RVLGQAKQEVE----------HKKKKL-------EA 1259

Query: 216  NVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMT 275
             VQ LQ +  D +     L  K  ++++E+ +    L +     +  A  +  L +    
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319

Query: 276  QEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE 335
             +  +++   +K  V+ +L QLEEER  L+ +   LDE       E+E K N        
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDE-------EMEAKQN-------- 1361

Query: 336  YYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQ 395
              ER +  L  +L +          K L++ A      +EA+     R +K+++ +L +Q
Sbjct: 1362 -LERHISTLNIQLSDS--------KKKLQDFA----STVEALEEGKKRFQKEIE-NLTQQ 1407

Query: 396  HNKDKL---NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGL 452
            + +       LE+ KN+LQQEL++L   L+++     Q + +L+   RK +Q L   + +
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ----RQLVSNLEKKQRKFDQLLAEEKNI 1463

Query: 453  IASLQDSQERLQ------------------------NELDLTKDSLKETKDALLNVE--- 485
             +   D ++R +                         EL+ T   LK   + L++ +   
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523

Query: 486  GELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS------KLREELRL- 538
            G+   E ++ +  +    EE K +++++  +L+      LR E +      +   +L+  
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583

Query: 539  --QHEEDKKSAMSQLLQLK-----DREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQS 591
              Q+EE ++    QL + +     +R++ A   + +KK+E  L  + L   +      ++
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA 1643

Query: 592  QTSLQQLQAQ---FTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRA 648
               L++LQAQ   F +E +      +E+    ++  K  K       Q  E+    E+  
Sbjct: 1644 IKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703

Query: 649  LENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEG---KAMLASLRSEL 705
             +  L+++  AE  +   + R +++  +  +E  +  L  ELE+E    +AM   +R   
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763

Query: 706  NHQHAAAIDL-LRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR----- 759
                  + +L    +  Q+  +A+ +LE       RQ+KE   ++ +++  ++ +     
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLE-------RQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 760  ---EHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRES 816
               E  I++L+++V+       A TK L+ K K++  I  +   +    +M E+Y  +E 
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE---RKMAEQY--KEQ 1871

Query: 817  KPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLEL 852
              +    + +LK  L E ++  +++  + +  Q EL
Sbjct: 1872 AEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907



 Score =  105 bits (261), Expect = 3e-22
 Identities = 117/517 (22%), Positives = 244/517 (47%), Gaps = 60/517 (11%)

Query: 385  KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 444
            K  LQ+  +E+  + K +  +   + QQ+ EN  + LE K +   +E   LQ+ ++   +
Sbjct: 842  KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 445  GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 504
                AE +   L   ++ L+  L   +  L+E +D    ++ E ++  QQ  +    ++E
Sbjct: 902  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 505  EE----KLKVDKMAHDLEIKWTEN----LRQECSKLREELRLQHEE---------DKKSA 547
            EE    KL+++K+  + +IK  E+    +  + +KL +E +L  E          +++  
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 548  MSQLLQLKDREKN--AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE 605
               L +LK++ ++  +  +   KK E    ++  LK+ LE   S     +  LQAQ  + 
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081

Query: 606  RQRLTQELEE-------LEEQHQQRHKSLKEAHVLA--FQTMEEEKEKEQRALENHLQQK 656
            + +L ++ EE       L+++  Q++ +LK+   L      ++E+ + E+ A     +QK
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141

Query: 657  H--SAELQSLKDAHRESMEG------FRIEMEQELQTLRFELEDEGKAMLASLRSELNHQ 708
                 EL++LK    ++++        R + EQE+  L+  L++E ++  A ++ E+  +
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ-EMRQK 1200

Query: 709  HAAAIDLLRHNHHQ------ELAAAKMELER-SIDIS--------RRQSKEH-----ICR 748
            HA A++ L     Q       L   K  LE+ + D++         +Q  EH       +
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260

Query: 749  ITDLQEELRHREHHISELDKEVQHLHENISALTKEL-EFKGKEILRIRSESNQQIRLEEM 807
            + +LQ +    E   +EL+ +V  L   + ++T  L E +GK I   +  ++   +L++ 
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320

Query: 808  EEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIED 844
            +E  L++E   + + + T+L+ +  ER+ +  +L E+
Sbjct: 1321 QE--LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355



 Score = 38.5 bits (88), Expect = 0.031
 Identities = 50/228 (21%), Positives = 97/228 (42%), Gaps = 27/228 (11%)

Query: 37   EVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQ 96
            E EE+  +    L     LQ     D++  LE   A    E++E   + +  S  V K  
Sbjct: 1709 EKEELAEELASSLSGRNALQ-----DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763

Query: 97   EKAEELHR---------MEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLK 147
            ++AE+L            + ES  + LE    E +  + + EG +   +S ++  +  L+
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALE 1820

Query: 148  RSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMV-----QDEAGSLLDK 202
                   E ++    ++    K  + ++  L++ + +++ E +M      Q E G+   K
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880

Query: 203  CQKLQTALAIAEN-----NVQVLQKQLDDAKEGEMALLSKHKEVESEL 245
              K Q   A  E+     N + LQ++LD+A E   A+  +   ++S+L
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928



 Score = 34.3 bits (77), Expect = 0.58
 Identities = 28/147 (19%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQF-E 60
            +QQ   + +  + ++ +M+   +++    I  +  ++ ++  + E++ R          +
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            KDK+L    LQ    R++ E  K Q +      KG  + ++L R ++E   +  + +   
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAE------KGNARVKQLKR-QLEEAEEESQRINAN 1899

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLK 147
            R+KL  + + +  ++     RE++ LK
Sbjct: 1900 RRKLQRELD-EATESNEAMGREVNALK 1925


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  136 bits (343), Expect = 8e-32
 Identities = 174/785 (22%), Positives = 338/785 (43%), Gaps = 135/785 (17%)

Query: 140  ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL 199
            ERE +     + FT   L+ + EK    RKE + +   L +    L+ ++Q  QD     
Sbjct: 844  EREKEMASMKEEFTR--LKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901

Query: 200  LDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDL 259
             ++C +L       E  V+ + ++L+D +E    L +K +++E E +     L++   DL
Sbjct: 902  EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS----ELKRDIDDL 957

Query: 260  VLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQL-EEERAFLRSKTQSLDEEQKQQ 318
             L    +  ++  +   E  +K+L  E + ++E +++L +E++A   +  Q+LD+ Q + 
Sbjct: 958  ELT---LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE- 1013

Query: 319  ILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVH 378
                E KVN   + + +  E+++ +L+  LE+E                       + V 
Sbjct: 1014 ----EDKVNTLTKAKVK-LEQQVDDLEGSLEQE-----------------------KKVR 1045

Query: 379  SNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ-------ELENLKEVLEDKLNTANQ- 430
             +  R K+KL+ DL +   +  ++LE DK QL +       EL  L   +ED+    +Q 
Sbjct: 1046 MDLERAKRKLEGDL-KLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQL 1104

Query: 431  --EIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA-------- 480
              ++  LQ  + + E+ L +     A ++  +  L  EL+   + L+E   A        
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164

Query: 481  ------LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLRE 534
                     +  +LE+   QHE T AA++++    V ++    +I   + ++Q+  K + 
Sbjct: 1165 KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE--QIDNLQRVKQKLEKEKS 1222

Query: 535  ELRLQHEEDKKSAMSQLLQLKD-------------REKNAARDSWQKKVEDLLNQISLLK 581
            E +L+  +D  S M Q+++ K               E  +  +  Q+ V DL +Q + L 
Sbjct: 1223 EFKLE-LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL- 1280

Query: 582  QNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEE 641
            Q    +LS+     + L +Q T+ +   TQ+LE+L+ Q ++  K+ K A   A Q+   +
Sbjct: 1281 QTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKA-KNALAHALQSARHD 1339

Query: 642  KEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASL 701
             +  +   E   + K  AELQ +       +  +R + E +      ELE+  K +   L
Sbjct: 1340 CDLLREQYEEETEAK--AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1397

Query: 702  RS---------------------------------ELNHQHAAAIDLLRHNHHQELAAAK 728
            +                                  E ++  AAA+D  + N  + LA  K
Sbjct: 1398 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1457

Query: 729  MELERS---IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELE 785
             + E S   ++ S+++++     +  L+        H+    +E ++L E IS LT++L 
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517

Query: 786  FKGKEILRIRSESNQQIRLEEMEEKYLMRESKP--------------EDIQMITELKAML 831
              GK I  +  +  +Q+  E+ME +  + E++               E  Q+  E++  L
Sbjct: 1518 SSGKTIHEL-EKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576

Query: 832  TERDQ 836
             E+D+
Sbjct: 1577 AEKDE 1581



 Score =  116 bits (290), Expect = 1e-25
 Identities = 192/875 (21%), Positives = 378/875 (43%), Gaps = 115/875 (13%)

Query: 3    QQALTEFEAYKHRVEDMQLCAEAQHVQRIVT------MSREVEEIRRKFEEKLRSFGQLQ 56
            Q+ L E +A   R+E+++   EA+   R         +SRE+EEI  + EE   + G   
Sbjct: 1105 QKKLKELQA---RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE---AGGATS 1158

Query: 57   VQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEE 116
            VQ E +K+   E  +   RR+++E     +  +A++ K        H   V  L + ++ 
Sbjct: 1159 VQIEMNKKREAEFQKM--RRDLEEATLQHEATAAALRKK-------HADSVAELGEQIDN 1209

Query: 117  LRLERKKLIEDYEGKLNKAQSFYERELD--TLKRSQLFTAES-LQASKEKEADLRKEFQG 173
            L+  ++KL         K +S ++ ELD  T    Q+  A++ L+       D   E + 
Sbjct: 1210 LQRVKQKL--------EKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRS 1261

Query: 174  QEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMA 233
            +    ++++  L ++   +Q E G L  +  + +  ++          +QL+D K     
Sbjct: 1262 KAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK----- 1316

Query: 234  LLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIK-DLESEKSRVNE 292
                 +++E E+ A     +   +  +  A H   L   Q  +E   K +L+   S+ N 
Sbjct: 1317 -----RQLEEEVKA-----KNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366

Query: 293  RLSQLEEE-RAFLRSKTQSLDEEQK---QQILELEKKVNEAKRTQQEYYERELKNLQSRL 348
             ++Q   +       +T+ L+E +K   Q++ E E+ V EA   +    E+    LQ+ +
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAV-EAVNAKCSSLEKTKHRLQNEI 1425

Query: 349  EEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKN 408
            E+ +  +  ++             A  A      R+  K+  + ++++ + +  LE  + 
Sbjct: 1426 EDLMVDVERSN-------------AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472

Query: 409  Q---LQQELENLKEVLEDKLN---TANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQER 462
            +   L  EL  LK   E+ L    T  +E  +LQ+ +    + LGS+   I  L+  +++
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532

Query: 463  LQNELDLTKDSLKETKDALLNVEG-------ELEQERQQHEETIAAMKEE-EKLKVD--K 512
            L+ E    + +L+E + +L + EG       E  Q + + E  +A   EE E+ K +  +
Sbjct: 1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLR 1592

Query: 513  MAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVED 572
            +   L+       R     LR + +++ + ++       +QL    + AA    QK+V+ 
Sbjct: 1593 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME-----IQLSHANRMAAEA--QKQVKS 1645

Query: 573  LLNQISLLKQNLEIQLSQSQTSLQQLQAQ--FTQERQRLTQ-ELEELEEQHQQRHKSLKE 629
            L    SLLK + +IQL  +  +   L+      + R  L Q ELEEL    +Q  +S K 
Sbjct: 1646 LQ---SLLK-DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRK- 1700

Query: 630  AHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFE 689
               LA Q + E  E+ Q      L    +  L + K      +   + E+E+ +Q  R  
Sbjct: 1701 ---LAEQELIETSERVQ------LLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 1751

Query: 690  LEDEGKAM--LASLRSELNHQH--AAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEH 745
             E   KA+   A +  EL  +   +A ++ ++ N  Q +   +  L+ +  I+ +  K+ 
Sbjct: 1752 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811

Query: 746  I----CRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQ 801
            +     R+ +L+ EL   +   +E  K ++     I  LT + E   K +LR++ +   +
Sbjct: 1812 LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ-DLVDK 1870

Query: 802  IRLEEMEEKYLMRESKPEDIQMITELKAMLTERDQ 836
            ++L+    K    E++ +    +++ + +  E D+
Sbjct: 1871 LQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 99/470 (21%), Positives = 201/470 (42%), Gaps = 54/470 (11%)

Query: 36   REVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQ--AAHRREIQELLKSQQDHSASVN 93
            ++ EE + + E   +    L  +  K K    E L+     +RE + L +   D +  + 
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517

Query: 94   KGQEKAEELH--RMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFY------------ 139
               +   EL   R ++E+    L+    E +  +E  EGK+ +AQ  +            
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577

Query: 140  --ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAG 197
              + E++  KR+ L   +SLQ S + E   R E    +  +   + +++ +L      A 
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAA 1637

Query: 198  SLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAAR------ER 251
                + + LQ+ L   +  +    +  DD KE    +  ++  +++EL   R      ER
Sbjct: 1638 EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTER 1697

Query: 252  LQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSL 311
             ++ A   +++ S    L  +Q T       L ++K +++  LSQL+ E      + ++ 
Sbjct: 1698 SRKLAEQELIETSERVQLLHSQNT------SLINQKKKMDADLSQLQTEVEEAVQECRNA 1751

Query: 312  DEEQKQQILELEKKVNEAKRTQ---------QEYYERELKNLQSRLEE----------EV 352
            +E+ K+ I +      E K+ Q         ++  E+ +K+LQ RL+E          + 
Sbjct: 1752 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811

Query: 353  TQLNEAHSKTLE-ELAWKHHMAIEAVHSNAIRDKKKLQMDLE-EQHNKDKLNLEEDKNQL 410
             Q  EA  + LE EL  +     E+V      +++  ++  + E+  K+ L L++  ++L
Sbjct: 1812 LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871

Query: 411  QQELENLK---EVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQ 457
            Q +++  K   E  E++ NT   +   +Q  + ++E+    AE  +  L+
Sbjct: 1872 QLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  136 bits (343), Expect = 8e-32
 Identities = 175/795 (22%), Positives = 360/795 (45%), Gaps = 147/795 (18%)

Query: 140  ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQM-VQDEAGS 198
            E+E+ T+K     T + L  S+ K  +L ++          T+ + K +LQ+ VQ E+ +
Sbjct: 847  EKEMATMKEEFQKTKDELAKSEAKRKELEEKLV--------TLVQEKNDLQLQVQAESEN 898

Query: 199  LLD---KCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQ 255
            LLD   +C +L  A    E  ++ + ++ +D +E    L +K +++E E +     L++ 
Sbjct: 899  LLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS----ELKKD 954

Query: 256  ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQL-EEERAFLRSKTQSLDEE 314
              DL L    +  ++  +   E  +K+L  E S ++E +++L  E++A   +  Q+LD+ 
Sbjct: 955  IDDLELT---LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL 1011

Query: 315  QKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAI 374
            Q +     E KVN   +T+ +  E+++++L+S LE+E                       
Sbjct: 1012 QAE-----EDKVNSLNKTKSK-LEQQVEDLESSLEQE----------------------- 1042

Query: 375  EAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELE-------NLKEVLEDKLNT 427
            + +  +  R+K+KL+ DL +   +  L+LE DK QL + L+        L+  +ED+   
Sbjct: 1043 KKLRVDLERNKRKLEGDL-KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL 1101

Query: 428  ANQ---EIGHLQDMVRKSEQGLGSAEGLIA-----------SLQDSQERLQNELDLTKDS 473
              Q   +I  LQ  + + E+ + +     A            L++  ERL+    +T   
Sbjct: 1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ 1161

Query: 474  L---KETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECS 530
            +   K+ +   L +  +LE+   QHE  +AA++++    V ++    +I   + ++Q+  
Sbjct: 1162 IELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGE--QIDNLQRVKQKLE 1219

Query: 531  KLREELRLQHEE---------DKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLK 581
            K + E +L+ ++           K+ + ++ +  + + + AR    ++++  L++++  K
Sbjct: 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK-NEEIQRSLSELTTQK 1278

Query: 582  QNLEI---QLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKE-AHVL---- 633
              L+    +LS+     + + +Q ++ +Q  TQ+ EEL+ Q ++ +K+    AH L    
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338

Query: 634  --------AFQTMEEEKEKEQRALE---------------------NHLQQKHSAELQSL 664
                     ++  +E K + QRAL                        L++      Q L
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1398

Query: 665  KDAHR--ESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQ 722
            +D+    E++      +E+  Q L+ E+ED        +  E  +  AAA+D  + N  +
Sbjct: 1399 QDSEEQVEAVNAKCASLEKTKQRLQGEVED------LMVDVERANSLAAALDKKQRNFDK 1452

Query: 723  ELAAAKMELERS---IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISA 779
             LA  K + E S   ++ S ++S+     +  L+         +  + +E ++L + I+ 
Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512

Query: 780  LTKELEFKGKEILRIRSESNQ--------QIRLEEMEEKYLMRESKPEDIQM-ITELKA- 829
            LT+++   GK I  +     Q        Q+ LEE E      E+K   IQ+ +T++K+ 
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572

Query: 830  ---MLTERDQIIKKL 841
                + E+D+ I++L
Sbjct: 1573 IDRKIAEKDEEIEQL 1587



 Score =  133 bits (334), Expect = 9e-31
 Identities = 191/915 (20%), Positives = 376/915 (41%), Gaps = 194/915 (21%)

Query: 39   EEIRRKFEEKL------RSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASV 92
            E  R++ EEKL      ++  QLQVQ E +  L  E+          +L+K++    A +
Sbjct: 868  EAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE-------RCDQLIKAKFQLEAKI 920

Query: 93   NKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLF 152
             +  E+AE+   +  E   K         K+ +ED   +L K       ++D L+ +   
Sbjct: 921  KEVTERAEDEEEINAELTAK---------KRKLEDECSELKK-------DIDDLELTLAK 964

Query: 153  TAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAI 212
              +   A++ K  +L +E  G    L +TI KL  E + +Q+     LD  Q  +  +  
Sbjct: 965  VEKEKHATENKVKNLTEELSG----LDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS 1020

Query: 213  AENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQAT 272
                   L++Q++D +      L + K++  +L   + +L+    DL             
Sbjct: 1021 LNKTKSKLEQQVEDLESS----LEQEKKLRVDLERNKRKLE---GDL------------- 1060

Query: 273  QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT----------QSLDEEQKQQILEL 322
            ++ QE +I DLE++K +++ERL + + E   L+SK           Q   +E + +I EL
Sbjct: 1061 KLAQE-SILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL 1119

Query: 323  EKKVNEAKRT------QQEYYERELKNLQSRLEE---------EVTQLNEAH----SKTL 363
            E+++   + T      Q+  Y REL+ L  RLEE         E+ +  EA      + L
Sbjct: 1120 EEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDL 1179

Query: 364  EELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLED 423
            EE   +H   + A+         +L   ++    + K  LE++K++ + E+++L   +E 
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQ-RVKQKLEKEKSEFKLEIDDLSSSME- 1237

Query: 424  KLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDS-------QERLQNELDLTKDSLKE 476
               + ++   +L+ + R  E  L  A G    +Q S       + RLQ E       L+E
Sbjct: 1238 ---SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294

Query: 477  TKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL 536
             +  +  +    +   QQ EE    ++EE K K + +AH L+     + R +C  LRE+ 
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAK-NALAHALQ-----SSRHDCDLLREQY 1348

Query: 537  RLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQ 596
              + E++ K+ + + L   + E    R  ++        ++   K+ L  +L  S+  ++
Sbjct: 1349 --EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE 1406

Query: 597  QLQAQ---FTQERQRLTQELEEL--------------------------------EEQHQ 621
             + A+     + +QRL  E+E+L                                EE   
Sbjct: 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466

Query: 622  QRHKSLKEAHVLAFQTME------------EEKEKEQRALENHLQQKHSAELQSLKDAHR 669
            +   SLKE+  L+ +  +            E  ++E + LE  +        ++ K  H 
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE 1526

Query: 670  ESMEGFRIEMEQELQTLRFELEDEGKAM-------------LASLRSELNHQHAAA---I 713
              +E  R ++E E   ++  LE+   A+             L  ++SE++ + A     I
Sbjct: 1527 --LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEI 1584

Query: 714  DLLRHNHHQELAAAKM------------------------ELERSIDISRRQSKEHICRI 749
            + L+ N+ + +   +                         E+E  +  + RQ+ E +  +
Sbjct: 1585 EQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHL 1644

Query: 750  TDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLEEMEE 809
              +Q +L+  + H+ +  +  + L E ++ + +       E+  +R+   Q  R  ++ E
Sbjct: 1645 RSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAE 1704

Query: 810  KYLMRESKPEDIQMI 824
            + L+  +  E +Q++
Sbjct: 1705 QELLDSN--ERVQLL 1717



 Score =  118 bits (295), Expect = 3e-26
 Identities = 188/860 (21%), Positives = 367/860 (42%), Gaps = 133/860 (15%)

Query: 3    QQALTEFEAYKHRVEDMQLCAEAQHVQRIVT------MSREVEEIRRKFEEKLRSFGQLQ 56
            Q+ + E +A   R+E+++   EA+   R  T       +RE+EE+  + EE   + G   
Sbjct: 1106 QKKIKELQA---RIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEE---AGGVTS 1159

Query: 57   VQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEE 116
             Q E +K+   E L+   RR+++E   +   H A V   ++K    H   V  L + ++ 
Sbjct: 1160 TQIELNKKREAEFLKL--RRDLEE---ATLQHEAMVAALRKK----HADSVAELGEQIDN 1210

Query: 117  LRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEA----DLRKEFQ 172
            L+  ++KL         K +S ++ E+D L  S    ++S +A+ EK      D   E +
Sbjct: 1211 LQRVKQKL--------EKEKSEFKLEIDDLSSSMESVSKS-KANLEKICRTLEDQLSEAR 1261

Query: 173  GQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQV-------LQKQLD 225
            G+   +++++ +L T+   +Q EAG L  + ++ ++ ++    + Q        L++QL+
Sbjct: 1262 GKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321

Query: 226  DAKEGEMAL-------------LSKHKEVESELAAARERLQQQASDLVLKASHIGMLQAT 272
            +  + + AL             L +  E E E  A  +R   +A+  V +        A 
Sbjct: 1322 EENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI 1381

Query: 273  QMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRT 332
            Q T+E     LE  K ++ +RL   EE+   + +K  SL++ +++   E+E  + + +R 
Sbjct: 1382 QRTEE-----LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERA 1436

Query: 333  QQ--EYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM 390
                   +++ +N    L E  T+  E+ ++    L     ++ E           KL+ 
Sbjct: 1437 NSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF---------KLKN 1487

Query: 391  DLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQ-EIGHLQDMVRKSEQGLGSA 449
              EE  ++ +    E+KN L+QE+ +L E + +   T ++ E    Q  + K++  L   
Sbjct: 1488 AYEEALDQLETVKRENKN-LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE 1546

Query: 450  EGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE----- 504
            E   A   +  + L+ +L+LT+    E    +   + E+EQ ++ ++ T+  M+      
Sbjct: 1547 EAEAALEHEEAKILRIQLELTQVK-SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE 1605

Query: 505  --------EEKLKVDKMAHDLEIKWTENLRQECSKLRE---------------ELRLQHE 541
                      K K++   +++EI+ +   RQ    L+                +  L+ +
Sbjct: 1606 VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQ 1665

Query: 542  EDKKSAMS------QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQ-TS 594
            ED K  ++       LLQ +  E  A  +  ++  +  L +  LL  N  +QL  +Q TS
Sbjct: 1666 EDLKEQLAIVERRANLLQAEVEELRATLEQTERARK--LAEQELLDSNERVQLLHTQNTS 1723

Query: 595  LQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQ 654
            L   + +   +  +L  E+E+     +   +  K+A +     M EE +KEQ     HL+
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKA-ITDAAMMAEELKKEQDT-SAHLE 1781

Query: 655  QKHSAELQSLKDAHRESMEGFRI----------EMEQELQTLRFELEDEGKAMLASLR-- 702
            +      Q++KD      E  ++          ++E  ++ L FELE E K    S++  
Sbjct: 1782 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGL 1841

Query: 703  -------SELNHQ-HAAAIDLLRHNHHQELAAAKME-LERSIDISRRQSKEHICRITDLQ 753
                    EL +Q      ++LR     +    K++  +R  + +  Q+  H+ +    Q
Sbjct: 1842 RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQ 1901

Query: 754  EELRHREHHISELDKEVQHL 773
             EL   E      + +V  L
Sbjct: 1902 HELEEAEERADIAESQVNKL 1921



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 105/497 (21%), Positives = 225/497 (45%), Gaps = 27/497 (5%)

Query: 307  KTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLN-EAHSKTLEE 365
            K+   ++E      E +K  +E  +++ +  E E K +    E+   QL  +A S+ L +
Sbjct: 842  KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901

Query: 366  LAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLE--EDKNQLQQELENLKEVLED 423
               +    I+A      + + K++   E   +++++N E    K +L+ E   LK+ ++D
Sbjct: 902  AEERCDQLIKA----KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957

Query: 424  ---KLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA 480
                L    +E    ++ V+   + L   +  IA L   ++ LQ       D L+  +D 
Sbjct: 958  LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017

Query: 481  LLNVEGELEQERQQHEETIAAMKEEEKLKVD------KMAHDLEIKWTENLRQECSKLRE 534
            + ++     +  QQ E+  +++++E+KL+VD      K+  DL++     L  E  K + 
Sbjct: 1018 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL 1077

Query: 535  ELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTS 594
            + RL+    KK      LQ K  ++      +QKK+++L  +I  L++ +E + + ++  
Sbjct: 1078 DERLK----KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA-TRAK 1132

Query: 595  LQQLQAQFTQERQRLTQELEEL--EEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENH 652
             ++ ++ + +E + L++ LEE       Q      +EA  L  +   EE   +  A+   
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192

Query: 653  LQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAA 712
            L++KH+  +  L +   ++++  + ++E+E    + E++D   +M +  +S+ N +    
Sbjct: 1193 LRKKHADSVAELGE-QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLE---K 1248

Query: 713  IDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQH 772
            I     +   E      E++RS+     Q         +L  +L  +E  +S+L +  Q 
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308

Query: 773  LHENISALTKELEFKGK 789
              +    L ++LE + K
Sbjct: 1309 FTQQTEELKRQLEEENK 1325



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 114/544 (20%), Positives = 229/544 (42%), Gaps = 71/544 (13%)

Query: 12   YKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALE--D 69
            +K + E+ Q   EA  ++   ++S E+ +++  +EE L    QL+    ++K L  E  D
Sbjct: 1457 WKTKCEESQAELEAS-LKESRSLSTELFKLKNAYEEAL---DQLETVKRENKNLEQEIAD 1512

Query: 70   LQ---AAHRREIQELLKSQQD---HSASVNKGQEKAEE-LHRMEVESLNKMLEELRLERK 122
            L    A + + I EL KS++      A +    E+AE  L   E + L   LE       
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE------- 1565

Query: 123  KLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTI 182
              +   + ++++  +  + E++ LKR+   T E++Q++ + E   R E    +  +   +
Sbjct: 1566 --LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 1623

Query: 183  GKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVE 242
             +++ +L     +A   L   + +Q  L       +  Q  LDDA  G+       ++++
Sbjct: 1624 NEIEIQLSHANRQAAETLKHLRSVQGQL-------KDTQLHLDDALRGQ-------EDLK 1669

Query: 243  SELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERA 302
             +LA    R         L  + +  L+AT    E   K  E E    NER+  L  +  
Sbjct: 1670 EQLAIVERRAN-------LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNT 1722

Query: 303  FLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKT 362
             L    + L+ +    +++L+ +V +A         R+ +N + + ++ +T       + 
Sbjct: 1723 SLIHTKKKLETD----LMQLQSEVEDA--------SRDARNAEEKAKKAITDAAMMAEEL 1770

Query: 363  LEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLE 422
             +E     H  +E +  N  +  K LQ  L+E    ++L L+  K Q+Q+        LE
Sbjct: 1771 KKEQDTSAH--LERMKKNLEQTVKDLQHRLDE---AEQLALKGGKKQIQK--------LE 1817

Query: 423  DKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASL-QDSQERLQNELDLTKDSLKETKDAL 481
             ++     E+   Q    +S +GL   E  +  L   S+E  +N L L +D + + +  +
Sbjct: 1818 TRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRL-QDLVDKLQVKV 1876

Query: 482  LNVEGELEQ-ERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 540
             + + + E+ + Q +       K + +L+  +   D+       LR +         + H
Sbjct: 1877 KSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVH 1936

Query: 541  EEDK 544
            E ++
Sbjct: 1937 ESEE 1940


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  136 bits (342), Expect = 1e-31
 Identities = 215/919 (23%), Positives = 405/919 (44%), Gaps = 118/919 (12%)

Query: 29   QRIVTMSREVEEIRRKFE--EKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQ 86
            Q+++ +  E + +  + E  E+ R+  Q+ +   + +R AL +       ++Q+  ++  
Sbjct: 617  QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA 676

Query: 87   DHSASVNKGQEKAEELH------RMEVESLNKMLEELRLERKKLIE------DYEGKLNK 134
            +  A +   QE+ EE+       R + E+    LE+L  E K+  E        +  L +
Sbjct: 677  ELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVR 736

Query: 135  AQSFYERELDTLKRSQLFTAESLQ---ASKEKEADLRKEFQGQEAILRKTIGKLKTELQM 191
             ++  E  L  ++R +   AE LQ   ++KE       E Q Q +++  T G+L+ ++Q 
Sbjct: 737  EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796

Query: 192  VQDEAGSLLD---KCQKLQ--TALAIAENNVQVLQKQLDDAK-EGEMALLSKHKEVESEL 245
            V  +A  ++    +C KL+  T  + AE       +QL  A+ EG+ AL  +    E E+
Sbjct: 797  VT-QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEV 855

Query: 246  AAARERLQQQASDLVLK-ASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFL 304
               RE+ +++ S    + A  +  L+  +M  E+ +K+ ++E   +    +Q EEER   
Sbjct: 856  NQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ---AQREEERTQA 912

Query: 305  RSKTQSLDEEQKQQ-------ILELEKKVNEA----KRTQQEYYERELKN------LQSR 347
             S    +  E +++       +L+ +K++ +A    +R +Q+   ++LK       LQ++
Sbjct: 913  ESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQ 972

Query: 348  LEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLE-------------- 393
            L+E   +L EA  +  ++LA     A++   S+ ++DK  LQ  +E              
Sbjct: 973  LQEAQRELKEAARQHRDDLA-----ALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027

Query: 394  --EQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 451
              EQ  ++KL   ++ N++Q+ELE  K  L   L    Q +  LQ+     +Q L +   
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087

Query: 452  LIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 511
             +   Q  Q+ L  +++L +  +KE K+A       L QE Q  EE  A+   E++L+  
Sbjct: 1088 DMQEAQGEQKELSAQMELLRQEVKE-KEA-----DFLAQEAQLLEELEASHITEQQLRAS 1141

Query: 512  KMAHDLEIKWTE-NLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKV 570
              A + +    +  LR   S+L      Q   ++  A +QL  L    + A     + + 
Sbjct: 1142 LWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRP 1201

Query: 571  E----------------DLLNQISLLKQNLEI-------------QLSQSQTSLQQLQAQ 601
            E                D     SL K+   +             +L Q     QQ +  
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261

Query: 602  FTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEK--EKEQRALENHLQQKHS- 658
               + Q+L + L + E +  Q H  L++      Q  EE+   E +Q +LE+ L + H  
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321

Query: 659  -AELQS-LKDAHRESME--GFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAID 714
             A LQS L+ A  + ME  G R  ++   + L  ++E   +A +   R++ +       D
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE-HLQAAVVEARAQASAAGILEED 1380

Query: 715  LLRHNHHQELAAAKMELERS-IDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHL 773
            L       +L   ++E ER      + Q +  + +   LQE L      ++E ++EV+ L
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440

Query: 774  HENISALTKELEFKGKEILRIRS----ESNQQIRLEEMEEKYLMR-ESKPEDIQM-ITEL 827
               I  L K+ E + K  L + S    + NQ++ L++ + + L +  S  E + M + E 
Sbjct: 1441 RGQIQELEKQREMQ-KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499

Query: 828  KAMLTERDQIIKKLIEDNK 846
            +  LT + + I++L +D +
Sbjct: 1500 EQKLTVQREQIRELEKDRE 1518



 Score =  128 bits (321), Expect = 3e-29
 Identities = 201/905 (22%), Positives = 398/905 (43%), Gaps = 119/905 (13%)

Query: 21   LCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQL------QVQFEKDKRLALED---LQ 71
            L A+ +H+Q  V  +R         EE LR+          +V+ E+++  AL++   L+
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412

Query: 72   AAHRREIQELLK------SQQDHSASVNKGQ----EKAEELHRMEVESLNKMLEELRLER 121
             A  + +QE L       ++++      +GQ    EK  E+ +  +E L+  L++ R + 
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK-RNQE 1471

Query: 122  KKLIEDYEGKLNKAQSFYER-ELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180
              L ++   +L K +S  E   +   +R Q  T +     +E+  +L K+ + Q  +L  
Sbjct: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQ-----REQIRELEKDRETQRNVLEH 1526

Query: 181  TIGKLKTELQMVQDEAGSLLDKCQKLQT----ALAIAENN-----VQVLQKQLDDAKEGE 231
             + +L+ + QM++ + G + D  ++L T    AL + EN+      Q L K+L+  +E +
Sbjct: 1527 QLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQ 1586

Query: 232  MALLSKHKEVESELAAARERLQQQASDLVLKASHIGML--QATQMTQEVT-----IKDLE 284
               L+    +  +L    + LQ Q+S +    SH  +L  +  +  QEV      I++L+
Sbjct: 1587 RVALT---HLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643

Query: 285  SEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYEREL--- 341
             +K  + + L + ++E    + + Q L++++ +Q   LE+ + + K + +E   REL   
Sbjct: 1644 RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRER-GRELTTQ 1702

Query: 342  KNLQSRLEEEVTQLNEAHSKTLEELAW-----KHHMAIEAVHSNAIRD-KKKLQMDLEEQ 395
            + L     EE    ++A   +LE +       +  +  +  H + +++ K +L+  L+  
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762

Query: 396  HNK---DKLNLEEDKNQ---LQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSA 449
            H K     L L + + +   LQQ+L+  +E  E K  +   ++   Q  + + +Q L + 
Sbjct: 1763 HRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL 1822

Query: 450  EGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLK 509
            +      Q  +ER++ + D  + +L++    L    GEL+  ++Q      A + EE+L 
Sbjct: 1823 QQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ------ARRLEEELA 1876

Query: 510  VDKMAHDLEIKWTENLRQECSKLREELRLQHEE--DKKSAMSQLLQLKDREKNAARDSWQ 567
            V       E +  + L +    LR E R Q +     +   ++  Q  + E  A +DSW 
Sbjct: 1877 V-------EGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWL 1929

Query: 568  KKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSL 627
            +    L  +     Q LE   ++SQ+S  Q +A             E L+E   + H +L
Sbjct: 1930 QAQAVLKER----DQELEALRAESQSSRHQEEA--------ARARAEALQEALGKAHAAL 1977

Query: 628  --KEAHVLAFQTMEEEKEKEQRALENHLQ--QKHSAELQSLKDAHRESMEGFRI-EMEQE 682
              KE H+L    +    E     L+  L   Q HS +L+          E  RI E E +
Sbjct: 1978 QGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE----------EALRIQEGEIQ 2027

Query: 683  LQTLRFELE-DEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ 741
             Q LR++ +  + +  LA    EL HQ      LL  +  Q +    ++ ++++   R +
Sbjct: 2028 DQDLRYQEDVQQLQQALAQRDEELRHQQERE-QLLEKSLAQRVQENMIQEKQNLGQEREE 2086

Query: 742  SKEHICRITDLQEELRHREHHISELDKEVQHLHE-----NISALTKELEFKGKEILRIRS 796
             +     I  L + +R  +  +++ ++E+  L E     N+ AL    +    E   ++ 
Sbjct: 2087 EE-----IRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKL 2141

Query: 797  ESNQQIRLEEMEE-KYLMRESKPEDI---QMITELKAMLTERDQIIKKLIEDNKFYQLEL 852
            +S +     E+E  +  +R+++  +I   +   +L   L +    +  L E   F Q  +
Sbjct: 2142 DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASV 2201

Query: 853  VNRET 857
            + R++
Sbjct: 2202 LERDS 2206



 Score = 97.1 bits (240), Expect = 7e-20
 Identities = 152/718 (21%), Positives = 294/718 (40%), Gaps = 111/718 (15%)

Query: 1    MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
            +K Q   + +    +V +  L   +Q  Q IV + ++++E R + E K +S   LQ Q +
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLL-SQREQEIVVLQQQLQEAREQGELKEQS---LQSQLD 1806

Query: 61   KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
            + +R       A   +E++ L + QQ       + +EKA+        +L   LE+  + 
Sbjct: 1807 EAQRAL-----AQRDQELEALQQEQQQAQGQEERVKEKAD--------ALQGALEQAHMT 1853

Query: 121  RKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRK 180
             K    +  G+L      ++ +   L+         +QA +E   DLR E + QE  L  
Sbjct: 1854 LK----ERHGELQD----HKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA 1905

Query: 181  TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKE 240
               +   + Q  + E  +L D   + Q  L   +  ++ L+ +   ++  E A  ++ + 
Sbjct: 1906 LQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965

Query: 241  VESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEE 300
            ++  L  A   LQ +   L+ +A     L+A+  T + ++   ++          QLEE 
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSR-------QLEEA 2018

Query: 301  RAFLRSKTQSLD---EEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQ--L 355
                  + Q  D   +E  QQ+ +   + +E  R QQE  +   K+L  R++E + Q   
Sbjct: 2019 LRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQ 2078

Query: 356  NEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHN---------------KDK 400
            N    +  EE+   H    E   + A ++++ L++   +Q N               +  
Sbjct: 2079 NLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQS 2138

Query: 401  LNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD-- 458
            L L+  + +LQ+ELE L+  L     T  +EI   ++  +     L   +  ++SLQ+  
Sbjct: 2139 LKLDSLEPRLQRELERLQAALRQ---TEAREI-EWREKAQDLALSLAQTKASVSSLQEVA 2194

Query: 459  ------------SQERLQNELDLTKDSLKE--------TKDALLNVEGEL---------- 488
                         Q+RLQ+EL+LT+ +L++        T  A L   GE           
Sbjct: 2195 MFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGV 2254

Query: 489  -------EQERQQHEETIAAMKEE-EKLKVDK---MAHDLEIKWT-ENLRQECSKL-REE 535
                     E+Q   + +  +++   +L++D+     H+++++ T E + +E  KL RE 
Sbjct: 2255 EAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREA 2314

Query: 536  LRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSL 595
            +R       + + +       ++    ++S  K V +L  ++ LL+  L ++  Q Q  +
Sbjct: 2315 MRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYI 2374

Query: 596  QQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHL 653
             +  AQ ++E   L          H   H  L  A       +E E  +   +L   L
Sbjct: 2375 TR-SAQTSRELAGL---------HHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSL 2422



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 167/806 (20%), Positives = 324/806 (40%), Gaps = 116/806 (14%)

Query: 71  QAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEG 130
           QAA  R+++   ++QQ  +  V K Q K  + +R   + L K LE       +  E+ E 
Sbjct: 35  QAASWRKLKNSQEAQQRQATLVRKLQAKVLQ-YRSWCQELEKRLEATGGPIPQRWENVE- 92

Query: 131 KLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAI---LRKTIGKLKT 187
                    E  LD L        +  ++  E    LR   +  + +   LR+ + KL  
Sbjct: 93  ---------EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTV 143

Query: 188 ELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMA-LLSKHKEVESELA 246
           +    +DE              L   E+  Q+ Q+      +GE   LLS  +EV +   
Sbjct: 144 DWSRARDE--------------LMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR 189

Query: 247 AARERLQQQASDLV-LKASHIGMLQATQMT--QEVTIKDLESEKSRVNERLSQLEEERAF 303
              E       DL+ LKA H+  L  + +T    +T+     E +       +   +   
Sbjct: 190 HFLEMKSATDRDLMELKAEHV-RLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLL 248

Query: 304 LRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTL 363
           L +KTQ L++E  ++  EL +  ++    + E  +R +  L + L +   Q NE + K +
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDR-VTELSALLTQSQKQ-NEDYEKMI 306

Query: 364 EELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLED 423
           + L       +E + +N          +L E       N +E+K  LQQ ++++ +V+ +
Sbjct: 307 KAL----RETVEILETN--------HTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVE 354

Query: 424 KLNTANQEIGH-------------------------LQDMVRKSEQGLGSAEGLIASLQD 458
           + +   Q  GH                         ++ ++ +  Q +      +A  Q+
Sbjct: 355 EGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQE 414

Query: 459 SQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLE 518
           +   LQ + D  ++  K  +  L  + GE         +T+A    + + +VD ++ + E
Sbjct: 415 AVNLLQQQHDQWEEEGKALRQRLQKLTGE--------RDTLAGQTVDLQGEVDSLSKERE 466

Query: 519 IKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQIS 578
           +           K REELR Q E  ++ A    L+  + E     DS Q + E+   ++ 
Sbjct: 467 L---------LQKAREELRQQLEVLEQEAWR--LRRVNVELQLQGDSAQGQKEEQQEELH 515

Query: 579 LLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKE-AHVLAFQT 637
           L  +  E    + Q  L  L+A+ ++    L    E LE  H +     +E   V A   
Sbjct: 516 LAVRERE----RLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571

Query: 638 MEEEKEKEQRALENHLQQKHSAELQSLK---DAHRESMEGFRIEMEQELQTLRFELEDEG 694
             E+   E  + EN L+ +  A+L++      A  E++   ++ + Q+L     +LE+E 
Sbjct: 572 RAEQSIAELSSSENTLKTE-VADLRAAAVKLSALNEALALDKVGLNQQL----LQLEEEN 626

Query: 695 KAMLASLRSELNHQHAAAIDLLRHNHHQE-LAAAKMELERSIDISRRQSKEHICRITDLQ 753
           +++ + + +    ++A  +DL      +E L      LE  +  +     E    + D+Q
Sbjct: 627 QSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQ 686

Query: 754 EELRHREHHISELDKEVQHLHENISALTKELEFKGKEILR--------IRSESNQQIRLE 805
           EE    +  +SE   + +     +  L +E + + + + R        +R ++  ++RL+
Sbjct: 687 EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746

Query: 806 EMEEKYLMRESKPEDIQMITELKAML 831
            +E     R+   E +Q ++  K +L
Sbjct: 747 AVERD---RQDLAEQLQGLSSAKELL 769



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 149/730 (20%), Positives = 301/730 (41%), Gaps = 97/730 (13%)

Query: 205 KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQ---------Q 255
           K Q+   + E  V  LQ+Q+ + +      L   +E +   A    +LQ          Q
Sbjct: 12  KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQ 71

Query: 256 ASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQ 315
             +  L+A+   + Q  +  +E  + +L        +R   L E    LR   +  D   
Sbjct: 72  ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131

Query: 316 KQQILELEKKVNEAKRT-------------QQEYYERELKNLQSRL----EEEVT----- 353
           K    ++EK   +  R              +QE+++  LK    RL     E VT     
Sbjct: 132 KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191

Query: 354 -QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQ---------MDLEEQHNKDKL-- 401
            ++  A  + L EL  +H     ++ +  +R     Q         MD  E      L  
Sbjct: 192 LEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA 251

Query: 402 ---NLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQD 458
               LE++ ++  QEL  LK   + +       +  L  ++ +S++     E +I +L++
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRE 311

Query: 459 S--------QERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIA-AMKEEEKLK 509
           +         E +++E  L++++ +E K +L  V  ++ Q   +  + IA     E  L+
Sbjct: 312 TVEILETNHTELMEHEASLSRNA-QEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370

Query: 510 VDKMA------HDLEIKWT-------------ENLRQECSKLREELR-LQHEEDKKSAMS 549
           +D          D +   T             ++LRQ+ +  +E +  LQ + D+     
Sbjct: 371 LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEG 430

Query: 550 QLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRL 609
           + L+ + ++    RD+   +  DL  ++  L +  E+ L +++  L+Q      QE  RL
Sbjct: 431 KALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKEREL-LQKAREELRQQLEVLEQEAWRL 489

Query: 610 TQELEELEEQ----HQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLK 665
            +   EL+ Q      Q+ +  +E H+      E E+ +E        Q +  +EL +L+
Sbjct: 490 RRVNVELQLQGDSAQGQKEEQQEELHL---AVRERERLQEMLMGLEAKQSESLSELITLR 546

Query: 666 DAHRES-MEGFRIEMEQELQTLRFELEDEGKAMLAS----LRSELNHQHAAAIDLLRHNH 720
           +A   S +EG  +  EQ   T      ++  A L+S    L++E+    AAA+ L   N 
Sbjct: 547 EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN- 605

Query: 721 HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHR-EHHISELDKEVQHLHENISA 779
            + LA  K+ L + + +   +  + +C   +  E+ R+  +  ++E +K  + L E  + 
Sbjct: 606 -EALALDKVGLNQQL-LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663

Query: 780 LTKELEFKGKEILRIRSESNQQIRLEEMEEKYLMRESKPEDIQMITELKAMLTE---RDQ 836
           L  +L+ K +E         + I+ E+ E +  + ES+ +     T+L+ +  E   +++
Sbjct: 664 LEAQLQ-KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEE 722

Query: 837 IIKKLIEDNK 846
           ++ + +++ +
Sbjct: 723 VLARAVQEKE 732


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  134 bits (337), Expect = 4e-31
 Identities = 205/915 (22%), Positives = 396/915 (43%), Gaps = 116/915 (12%)

Query: 3    QQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKD 62
            Q   ++F+A    +E+++  AE         + +   +I+   E+  R     +++ EK 
Sbjct: 1066 QAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL--TYEIEDEKR 1123

Query: 63   KRLALEDLQAAHRREIQELLKSQQDHSASVNKGQ---EKAEELHRMEVESLNKMLEELRL 119
            +R ++ED     + +  +L K++Q    ++   +   EKA +    E+E L  +L+E   
Sbjct: 1124 RRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGT 1183

Query: 120  ERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILR 179
             ++    +YE +L K ++ Y  E+  L R++  T  ++  +  KE  ++KE   +   LR
Sbjct: 1184 RKR----EYENELAKVRNHYNEEMSNL-RNKYETEINITKTTIKEISMQKEDDSKN--LR 1236

Query: 180  KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 239
              + +L  E + ++DE   L D   +       AE N   LQ++   ++     ++ K +
Sbjct: 1237 NQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENA--LQQKACGSE-----IMQKKQ 1289

Query: 240  EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 299
             +E EL   ++ +QQ++ D    A H   L+    T +   K++E  K+   E   +  E
Sbjct: 1290 HLEIEL---KQVMQQRSED---NARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE 1343

Query: 300  ERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEY----------YERELKNLQSR-- 347
                L     + DEE      + E ++N  K T  +           Y  ++ NL     
Sbjct: 1344 YENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENR 1403

Query: 348  -LEEEVTQLNEAHSKTLEELAWKHH--MAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLE 404
             L EE+ +L    ++T E L          +A  S   + K++L+++L +          
Sbjct: 1404 SLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRT---- 1459

Query: 405  EDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQ 464
            E+  + +Q L++  + ++DK    N+EI  L+ ++ K        E   A LQ    R+Q
Sbjct: 1460 EESVRYKQSLDDAAKTIQDK----NKEIERLKQLIDKETNDRKCLEDENARLQ----RVQ 1511

Query: 465  NELDLTKDSLKETKDALLNVEGEL----------EQERQQHEETIAAMKEEEK-LKVDKM 513
             +L     S  ET + L   E EL           QER   ++ I   +   K L++ K 
Sbjct: 1512 YDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQ 1571

Query: 514  AHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDL 573
              + E+   +    E S  R++L  + E  ++S   Q +++ +  +              
Sbjct: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ------------- 1618

Query: 574  LNQISLLKQNLEIQLSQSQTSLQQ--LQAQFTQER-QRLTQELEELEEQHQQRHKSLKEA 630
            L Q S++K+  E  L Q +  L     + Q TQE  +RL+ E+E L  Q  Q  +S+K+A
Sbjct: 1619 LEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQA 1678

Query: 631  HVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLK-DAHRESMEGFRIEMEQELQTLRFE 689
            H+          E  Q+A+E+  +  + ++++  +  +  E++    + +E+EL+ LR E
Sbjct: 1679 HL--------RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLE 1730

Query: 690  LED----------EGKAMLASLRSELNHQHAAAIDL--LRHNHHQELAAAKMELER---- 733
             +D          +  A +  LRS+L   +   ++L  L ++  +E    + E+E+    
Sbjct: 1731 YDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQ 1790

Query: 734  SIDISRR--QSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEI 791
            +++ S R  +SK    ++   +E L  +   + +    +Q L + ++     LE + +  
Sbjct: 1791 ALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVK 1850

Query: 792  LRIRSESNQ-QIRLEEMEEKYLMRESKPEDIQMITE--------LKAMLTERDQIIKKLI 842
             R+  E  Q Q  L + + +Y  +E     I+   E        L++ + ER Q   K I
Sbjct: 1851 QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI-ERLQAEIKRI 1909

Query: 843  EDNKFYQLELVNRET 857
            E+    +LE   RET
Sbjct: 1910 EERCRRKLEDSTRET 1924



 Score =  108 bits (269), Expect = 3e-23
 Identities = 154/772 (19%), Positives = 345/772 (44%), Gaps = 105/772 (13%)

Query: 2    KQQALTEFEAYKHRVEDMQLCAEAQHVQ---RIVTMSREVEEIRRK--FEEKLRSFGQLQ 56
            +Q+   E  A + +    ++  + QH++   + V   R  +  R K   EE  ++     
Sbjct: 1265 EQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI---- 1320

Query: 57   VQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRM---EVESLNKM 113
                +DK   +E L+A  + E +   + + + S   N   E+   L      E+      
Sbjct: 1321 ----QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT 1376

Query: 114  LEELRLERKKLIEDYEGK---LNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKE 170
            + +L +++++    Y  +   L +       E+  LK +   T E+L+  +E   D++++
Sbjct: 1377 IHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEE---DIQQQ 1433

Query: 171  -FQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKE 229
               G E   RK   +L+ EL+ V        ++  + + +L  A   +Q   K+++  K+
Sbjct: 1434 KATGSEVSQRKQ--QLEVELRQVTQMR---TEESVRYKQSLDDAAKTIQDKNKEIERLKQ 1488

Query: 230  GEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSR 289
                L+ K       L     RLQ+   DL    S      AT+   ++ +++ E  + R
Sbjct: 1489 ----LIDKETNDRKCLEDENARLQRVQYDLQKANS-----SATETINKLKVQEQELTRLR 1539

Query: 290  VN-ERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQE------YYERELK 342
            ++ ER+SQ    +    ++ Q+  +E + Q  ++E+++N  KRT  E        E EL+
Sbjct: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELE 1599

Query: 343  NLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLN 402
             ++  L+E+  ++    ++ LE+ +         +      D  + Q D+ + H ++K  
Sbjct: 1600 GMRRSLKEQAIKITNL-TQQLEQAS---------IVKKRSEDDLRQQRDVLDGHLREKQR 1649

Query: 403  LEEDKNQLQQELENLKEVL---EDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDS 459
             +E+  +L  E+E L+  L   ++ +  A+    H Q  +    + L  ++  I  LQ  
Sbjct: 1650 TQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSL 1709

Query: 460  QERLQNELDLTKDSLKETK---DALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHD 516
             E L  E  + ++ L+  +   D L     E + ++     TI  ++ + ++  ++    
Sbjct: 1710 TENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNA---TILELRSQLQISNNRT--- 1763

Query: 517  LEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQ 576
            LE+   + L  +  + RE LR + E+ +K A+    ++++  KN      Q++ E LL +
Sbjct: 1764 LEL---QGLINDLQRERENLRQEIEKFQKQALEASNRIQE-SKNQCTQVVQER-ESLLVK 1818

Query: 577  ISLLKQN------LEIQLSQSQTSLQ---QLQAQFTQERQRLTQELEELEEQHQQRHKSL 627
            I +L+Q+      LE +L++++++L+   +++ +   E+Q++  +L + + Q+ ++ +++
Sbjct: 1819 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878

Query: 628  KEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLR 687
            ++      ++  E+ E+E+ +L + +++   AE++ +++  R  +E    E + +L+T R
Sbjct: 1879 RK-----IESEREKSEREKNSLRSEIERLQ-AEIKRIEERCRRKLEDSTRETQSQLETER 1932

Query: 688  FELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 739
               + E                   ID LR   +      + E E ++D S+
Sbjct: 1933 SRYQRE-------------------IDKLRQRPYGSHRETQTECEWTVDTSK 1965



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 103/528 (19%), Positives = 241/528 (45%), Gaps = 37/528 (7%)

Query: 1    MKQQALTEFEAYKHRVEDMQLCAEAQHVQRI-----VTMSREVEEIRRKFEEKLRSFGQL 55
            ++QQ  T  E  + +    QL  E + V ++     V   + +++  +  ++K +   +L
Sbjct: 1430 IQQQKATGSEVSQRK---QQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERL 1486

Query: 56   QVQFEKDK--RLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVE----- 108
            +   +K+   R  LED  A  +R   +L K+    + ++NK + + +EL R+ ++     
Sbjct: 1487 KQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVS 1546

Query: 109  -----------SLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESL 157
                            L+EL+L+++K +E+   +L +  S    +   L+        SL
Sbjct: 1547 QERTVKDQDITRFQNSLKELQLQKQK-VEEELNRLKRTASEDSCKRKKLEEELEGMRRSL 1605

Query: 158  QASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNV 217
            +    K  +L ++ + Q +I++K   + + +L+  +D     L + Q+ Q  L    + V
Sbjct: 1606 KEQAIKITNLTQQLE-QASIVKK---RSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEV 1661

Query: 218  QVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQE 277
            + L++QL   +E       +++  +  +      L +   ++    S    L    +  E
Sbjct: 1662 EALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLE 1721

Query: 278  VTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYY 337
              +++L  E   +    S+ + ++     + +S  +    + LEL+  +N+ +R ++E  
Sbjct: 1722 EELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQR-ERENL 1780

Query: 338  ERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHN 397
             +E++  Q +  E   ++ E+ ++  + +  +  + ++       +DK +LQ  LE++ N
Sbjct: 1781 RQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE--QDKARLQR-LEDELN 1837

Query: 398  KDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQ 457
            + K  LE +  +++Q LE  K+ +++ LN    +    ++ +RK E     +E    SL+
Sbjct: 1838 RAKSTLEAE-TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLR 1896

Query: 458  DSQERLQNELDLTKDSL-KETKDALLNVEGELEQERQQHEETIAAMKE 504
               ERLQ E+   ++   ++ +D+    + +LE ER +++  I  +++
Sbjct: 1897 SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1944


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  133 bits (335), Expect = 7e-31
 Identities = 165/790 (20%), Positives = 360/790 (45%), Gaps = 97/790 (12%)

Query: 140  ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL 199
            E+E+ T+K       E+L+ S+ +    RKE + +   L +    L+ ++Q  QD     
Sbjct: 848  EKEMATMKEEFGRIKETLEKSEAR----RKELEEKMVSLLQEKNDLQLQVQAEQDNLNDA 903

Query: 200  LDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDL 259
             ++C +L       E  V+ + ++L+D +E    L +K +++E E +     L++   DL
Sbjct: 904  EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS----ELKKDIDDL 959

Query: 260  VLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQL-EEERAFLRSKTQSLDEEQKQQ 318
             L    +  ++  +   E  +K+L  E + ++E +++L +E++A   +  Q+LD+ Q + 
Sbjct: 960  ELT---LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE- 1015

Query: 319  ILELEKKVNEAKRTQQEYYERELKNLQSRLEEEV---TQLNEAHSKTLEELAWKHHMAIE 375
                E KVN   +++ +  E+++ +L+  LE+E      L  A  K   +L         
Sbjct: 1016 ----EDKVNSLSKSKVK-LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDL--------- 1061

Query: 376  AVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHL 435
             +   +I D +  ++ LEE+  K + ++ +  ++++ E + L   L+ KL      I  L
Sbjct: 1062 KLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDE-QVLALQLQKKLKENQARIEEL 1120

Query: 436  QDMVRKSEQGLGSAEGLIASLQDSQERLQNELD-------LTKDSLKETKDALLNVEGEL 488
            ++ +          E L + L    E +   L+       +  +  K+ +     +  +L
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1180

Query: 489  EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAM 548
            E+   QHE T AA++++    V ++    +I   + ++Q+  K + E +L+  +D  S M
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGE--QIDNLQRVKQKLEKEKSEFKLE-LDDVTSNM 1237

Query: 549  SQLLQLKDREKNAAR------DSWQKKVEDL---LNQISLLKQNLEIQLSQSQTSLQQLQ 599
             Q+++ K   +  +R      + ++ K+E+    LN  +  +  L+ +  +    L++ +
Sbjct: 1238 EQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKE 1297

Query: 600  A---QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTM---------EEEKEKEQR 647
            A   Q T+ +   TQ++E+L+ Q ++  K+ K A   A Q+          + E+E E +
Sbjct: 1298 ALISQLTRGKLSYTQQMEDLKRQLEEEGKA-KNALAHALQSARHDCDLLREQYEEETEAK 1356

Query: 648  ALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLA-------- 699
            A    +  K ++E+   +  +         E+E+  + L   L+D  +A+ A        
Sbjct: 1357 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSL 1416

Query: 700  -----SLRSEL---------NHQHAAAIDLLRHNHHQELAAAKMELERS---IDISRRQS 742
                  L++E+         ++  AAA+D  + N  + LA  K + E S   ++ S++++
Sbjct: 1417 EKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEA 1476

Query: 743  KEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQI 802
            +     +  L+        H+    +E ++L E IS LT++L   GK +  +  +  +Q+
Sbjct: 1477 RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL-EKVRKQL 1535

Query: 803  RLEEMEEKYLMRESKP----EDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETN 858
             +E++E +  + E++     E+ +++         + +I +KL E ++    E+   + N
Sbjct: 1536 EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE----EMEQAKRN 1591

Query: 859  FNKVFNSSPT 868
              +V +S  T
Sbjct: 1592 HQRVVDSLQT 1601



 Score =  119 bits (298), Expect = 1e-26
 Identities = 206/892 (23%), Positives = 373/892 (41%), Gaps = 157/892 (17%)

Query: 3    QQALTEFEAYKHRVEDMQLCAEAQHVQRIVT------MSREVEEIRRKFEEKLRSFGQLQ 56
            Q+ L E +A   R+E+++   EA+   R         +SRE+EEI  + EE   + G   
Sbjct: 1107 QKKLKENQA---RIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE---AGGATS 1160

Query: 57   VQFEKDKRLALE------DLQAA--------------HRREIQELLKSQQDHSASVNKGQ 96
            VQ E +K+   E      DL+ A              H   + EL   Q D+   V +  
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL-GEQIDNLQRVKQKL 1219

Query: 97   EKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS-QLFTAE 155
            EK +   ++E++ +   +E++ ++ K  +E     L    + Y  +L+  +RS   FT +
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQI-IKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQ 1278

Query: 156  SLQASKEKEADLRKEFQGQEAILRK-TIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAE 214
              +   E   +L ++ + +EA++ + T GKL    QM  ++    L++  K + ALA A 
Sbjct: 1279 RAKLQTEN-GELARQLEEKEALISQLTRGKLSYTQQM--EDLKRQLEEEGKAKNALAHA- 1334

Query: 215  NNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQM 274
                 LQ    D       LL +  E E+E  A  +R+  +A+  V +        A Q 
Sbjct: 1335 -----LQSARHDCD-----LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1384

Query: 275  TQEVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRT-- 332
            T+E     LE  K ++ +RL   EE    + +K  SL++ + +   E+E  + + +R+  
Sbjct: 1385 TEE-----LEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1439

Query: 333  -------QQEYYERELKNLQSRLEEEVTQLN----EAHSKTLEELAWKHHMAIEAVHSNA 381
                   +Q  +++ L   + + EE  ++L     EA S + E    K+       H   
Sbjct: 1440 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1499

Query: 382  I-RDKKKLQ---MDLEEQHNKDKLN---LEEDKNQLQQELENLKEVLEDKLNTANQEIGH 434
              R+ K LQ    DL EQ  +   N   LE+ + QL+ E   L+  LE+   +   E G 
Sbjct: 1500 FKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGK 1559

Query: 435  LQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDA-------LLNV--- 484
            +     +  Q     E  +A   +  E+ +       DSL+ + DA       +L V   
Sbjct: 1560 ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKK 1619

Query: 485  -EGELEQERQQ--HEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHE 541
             EG+L +   Q  H   +AA  +++   +  +  D +I+  + +R     L+E + +   
Sbjct: 1620 MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN-DDLKENIAIVER 1678

Query: 542  EDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQ-TSLQQLQA 600
             +       LLQ +  E  A  +  ++  +  L +  L++ +  +QL  SQ TSL   + 
Sbjct: 1679 RNN------LLQAELEELRAVVEQTERSRK--LAEQELIETSERVQLLHSQNTSLINQKK 1730

Query: 601  QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 660
            +   +  +L  E+EE  ++ +   +  K+A +     M EE +KEQ           SA 
Sbjct: 1731 KMESDLTQLQSEVEEAVQECRNAEEKAKKA-ITDAAMMAEELKKEQDT---------SAH 1780

Query: 661  LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNH 720
            L+ +K             MEQ ++ L+  L++  +  L   + +L               
Sbjct: 1781 LERMKK-----------NMEQTIKDLQHRLDEAEQIALKGGKKQL--------------- 1814

Query: 721  HQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQHLHEN---I 777
             Q+L A   ELE  ++  ++++ E +       + +R  E  I EL  + +   +N   +
Sbjct: 1815 -QKLEARVRELEGELEAEQKRNAESV-------KGMRKSERRIKELTYQTEEDKKNLLRL 1866

Query: 778  SALTKELEFKGKEILRIRSESNQQI------------RLEEMEEKYLMRESK 817
              L  +L+ K K   R   E+ +Q              L+E EE+  + ES+
Sbjct: 1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQ 1918



 Score = 90.5 bits (223), Expect = 7e-18
 Identities = 143/647 (22%), Positives = 267/647 (41%), Gaps = 125/647 (19%)

Query: 32   VTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELL--------- 82
            +  + E+EE ++K  ++L+   +  V+    K  +LE  +   + EI++L+         
Sbjct: 1382 IQRTEELEEAKKKLAQRLQD-AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440

Query: 83   -----KSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQS 137
                 K Q++    + + ++K EE  + E+ES  K    L  E  KL   YE  L   ++
Sbjct: 1441 AAALDKKQRNFDKILAEWKQKYEE-SQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1499

Query: 138  FYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAG 197
            F +RE   L+       E L    +   +L K        +RK +   K ELQ   +EA 
Sbjct: 1500 F-KRENKNLQEEISDLTEQLGEGGKNVHELEK--------VRKQLEVEKLELQSALEEA- 1549

Query: 198  SLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQAS 257
                     + +L   E  +   Q + +  K           E+E +LA   E ++Q   
Sbjct: 1550 ---------EASLEHEEGKILRAQLEFNQIKA----------EIERKLAEKDEEMEQAKR 1590

Query: 258  D--LVLKASHIGMLQATQMTQEV--TIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDE 313
            +   V+ +    +   T+   EV    K +E + + +  +LS      A  + + +SL  
Sbjct: 1591 NHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQS 1650

Query: 314  EQKQQILELEKKV--NEAKRTQQEYYERELKNLQSRLEE--EVTQLNEAHSKTLEELAWK 369
              K   ++L+  V  N+  +      ER    LQ+ LEE   V +  E   K  E+   +
Sbjct: 1651 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1710

Query: 370  HHMAIEAVHS---NAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKE--VLEDK 424
                ++ +HS   + I  KKK++ DL +  ++ +  ++E +N  ++  + + +  ++ ++
Sbjct: 1711 TSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEE 1770

Query: 425  LNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLT----KDSLKETKDA 480
            L        HL+ M +  EQ          +++D Q RL     +     K  L++ +  
Sbjct: 1771 LKKEQDTSAHLERMKKNMEQ----------TIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1820

Query: 481  LLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQH 540
            +  +EGELE E++++ E++  M++ E+           IK              EL  Q 
Sbjct: 1821 VRELEGELEAEQKRNAESVKGMRKSER----------RIK--------------ELTYQT 1856

Query: 541  EEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQA 600
            EEDKK+    LL+L+D             V+ L  ++   K+  E    Q+ T+L +   
Sbjct: 1857 EEDKKN----LLRLQD------------LVDKLQLKVKAYKRQAEEAEEQANTNLSKF-- 1898

Query: 601  QFTQERQRLTQELEELEE-----QHQQRHKSLKEAHVLAFQTMEEEK 642
                  +++  EL+E EE     + Q      K   + A Q M +E+
Sbjct: 1899 ------RKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDEE 1939


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.125    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,718,427
Number of Sequences: 37866
Number of extensions: 1707806
Number of successful extensions: 35030
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 614
Number of HSP's successfully gapped in prelim test: 1505
Number of HSP's that attempted gapping in prelim test: 10879
Number of HSP's gapped (non-prelim): 9983
length of query: 971
length of database: 18,247,518
effective HSP length: 112
effective length of query: 859
effective length of database: 14,006,526
effective search space: 12031605834
effective search space used: 12031605834
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.