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Search of human proteins with 153791192
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153791192 isthmin 1 homolog [Homo sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153791192 isthmin 1 homolog [Homo sapiens] 977 0.0
gi|40805858 isthmin 2 homolog isoform 1 [Homo sapiens] 348 8e-96
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 51 3e-06
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 49 1e-05
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 47 3e-05
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 46 8e-05
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 46 8e-05
gi|134031945 SCO-spondin [Homo sapiens] 46 8e-05
gi|118572606 hemicentin 1 [Homo sapiens] 45 1e-04
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 45 1e-04
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 44 2e-04
gi|145699139 cartilage intermediate layer protein 2 [Homo sapiens] 43 7e-04
gi|147904700 semaphorin 5A [Homo sapiens] 42 0.001
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 42 0.001
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 42 0.002
gi|145309328 papilin [Homo sapiens] 42 0.002
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 41 0.002
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 40 0.004
gi|16933525 unc5C [Homo sapiens] 40 0.006
gi|10092665 sushi domain containing 2 [Homo sapiens] 40 0.006
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 39 0.008
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 39 0.010
gi|189242612 complement component 6 precursor [Homo sapiens] 39 0.013
gi|169636415 complement component 6 precursor [Homo sapiens] 39 0.013
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 39 0.013
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 39 0.013
gi|209977117 unc-5 homolog D [Homo sapiens] 39 0.013
gi|4505737 complement factor properdin precursor [Homo sapiens] 38 0.017
gi|223671861 complement factor properdin precursor [Homo sapiens] 38 0.017
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 38 0.022
>gi|153791192 isthmin 1 homolog [Homo sapiens]
Length = 464
Score = 977 bits (2526), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETS 60
MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETS
Sbjct: 1 MVRLAAELLLLLGLLLLTLHITVLRGSGAADGPDAAAGNASQAQLQNNLNVGSDTTSETS 60
Query: 61 FSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADING 120
FSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADING
Sbjct: 61 FSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADING 120
Query: 121 QNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKY 180
QNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKY
Sbjct: 121 QNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKY 180
Query: 181 DSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKR 240
DSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKR
Sbjct: 181 DSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKR 240
Query: 241 TRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERW 300
TRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERW
Sbjct: 241 TRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERW 300
Query: 301 MSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEI 360
MSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEI
Sbjct: 301 MSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEI 360
Query: 361 YKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDV 420
YKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDV
Sbjct: 361 YKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDV 420
Query: 421 LPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY 464
LPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY
Sbjct: 421 LPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY 464
>gi|40805858 isthmin 2 homolog isoform 1 [Homo sapiens]
Length = 571
Score = 348 bits (892), Expect = 8e-96
Identities = 184/392 (46%), Positives = 243/392 (61%), Gaps = 38/392 (9%)
Query: 104 LLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEADKD--QHPENKP-----SW--SVP 154
LL+L P+L A ++ NP+ QVTI+VV+ P +E D P N P SW ++
Sbjct: 187 LLELQKLPELVHATLSTPNPDNQVTIKVVEDPQAEVSIDLLAEPSNPPPQDTLSWLPALW 246
Query: 155 SPDWRAWWQRSLSLARANSG-----DQDY---------KYDSTSDDSN----FLNPPRGW 196
S W + A G D+DY + D D+ F W
Sbjct: 247 SFLWGDYKGEEKDRAPGEKGEEKEEDEDYPSEDIEGEDQEDKEEDEEEQALWFNGTTDNW 306
Query: 197 DH--TAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESR 254
D APG F KD YD + + +WS WS CS C G Q+RTR CGY CTATE+R
Sbjct: 307 DQGWLAPGDWVF--KDSVSYDY-EPQKEWSPWSPCSGNCSTGKQQRTRPCGYGCTATETR 363
Query: 255 TCDRPNCPGIED--TFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYM 312
TCD P+CPG ED T + E LLA NAT + + D DSCE+W++CKS+FL KY+
Sbjct: 364 TCDLPSCPGTEDKDTLGLPSEEWKLLAR----NATDMHDQDVDSCEKWLNCKSDFLIKYL 419
Query: 313 HKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSM 372
+++ DLPSCPC+YP E S + D + + FRW+DASGP+E+L+IY+PTAR+C+RSM
Sbjct: 420 SQMLRDLPSCPCAYPLEAMDSPVSLQDEHQGRSFRWRDASGPRERLDIYQPTARFCLRSM 479
Query: 373 LSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSR 432
LS ES+TLAAQHCCY ++ +L+TRGKGAG PNLIST+FS +LH+K D PWI+CKGDWSR
Sbjct: 480 LSGESSTLAAQHCCYDEDSRLLTRGKGAGMPNLISTDFSPKLHFKFDTTPWILCKGDWSR 539
Query: 433 YNEARPPNNGQKCTESPSDEDYIKQFQEAREY 464
+ PPNNG+ CT++P +E+Y+ Q QEA+EY
Sbjct: 540 LHAVLPPNNGRACTDNPLEEEYLAQLQEAKEY 571
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 50.8 bits (120), Expect = 3e-06
Identities = 24/54 (44%), Positives = 31/54 (57%), Gaps = 10/54 (18%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC--------GYACT--ATESRTCDRPNCP 262
G G WS W +CSVTCG G QKR+R C G C TE++ C++ +CP
Sbjct: 494 GWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCP 547
Score = 45.4 bits (106), Expect = 1e-04
Identities = 22/55 (40%), Positives = 30/55 (54%), Gaps = 5/55 (9%)
Query: 212 PEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSC---GYAC--TATESRTCDRPNC 261
P + DG WS W+ CS +CGNG Q+R RSC C ++ ++RTC C
Sbjct: 374 PSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQEC 428
Score = 40.4 bits (93), Expect = 0.003
Identities = 22/54 (40%), Positives = 26/54 (48%), Gaps = 10/54 (18%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC--------GYAC--TATESRTCDRPNCP 262
G WS WS CSVTCG+G R R C G C A E++ C + CP
Sbjct: 437 GWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACP 490
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 48.9 bits (115), Expect = 1e-05
Identities = 35/113 (30%), Positives = 41/113 (36%), Gaps = 17/113 (15%)
Query: 158 WRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDST 217
W W SL G + T PP+ G T
Sbjct: 348 WEEWSPWSLCSFTCGRGQRTRTRSCT--------PPQYGGRPCEGPETHHKPCNIALCPV 399
Query: 218 DGEG-DWSLWSVCSVTCGNGNQKRTRSC------GYACTA--TESRTCDRPNC 261
DG+ +WS WS CSVTC NG Q+R+R C G C ESR C P C
Sbjct: 400 DGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPEC 452
Score = 48.5 bits (114), Expect = 1e-05
Identities = 28/66 (42%), Positives = 36/66 (54%), Gaps = 10/66 (15%)
Query: 207 ETKDQPEYDSTDGEG---DWSLWSVCSVTCGNGNQKRTRSC----GYACTA--TESRTCD 257
E D ++ + GE +WS WS CSVTCG G+Q RTR+C G C+ ESR C+
Sbjct: 278 EQADAAKFMAQTGESGVEEWSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCN 337
Query: 258 RPN-CP 262
CP
Sbjct: 338 NTALCP 343
Score = 38.1 bits (87), Expect = 0.017
Identities = 20/59 (33%), Positives = 25/59 (42%), Gaps = 8/59 (13%)
Query: 212 PEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSC------GYAC--TATESRTCDRPNCP 262
PE + W WS CS +C G ++R R+C G C T E R C CP
Sbjct: 450 PECTANGQWNQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQRCP 508
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 47.4 bits (111), Expect = 3e-05
Identities = 25/66 (37%), Positives = 32/66 (48%), Gaps = 9/66 (13%)
Query: 213 EYDSTDGE-GDWSLWSVCSVTCGNGNQKRTRSC------GYAC--TATESRTCDRPNCPG 263
E +TD + G W+ WS+CS TC G Q+R R C GY C T E + C CP
Sbjct: 470 ECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPA 529
Query: 264 IEDTFR 269
+ R
Sbjct: 530 FHEMCR 535
Score = 45.8 bits (107), Expect = 8e-05
Identities = 24/49 (48%), Positives = 29/49 (59%), Gaps = 8/49 (16%)
Query: 222 DWSLWSVCSVTCGNGNQKRTRSC-----GYACTA--TESRTCDR-PNCP 262
+WS WSVCS+TCG G Q RTRSC G C+ E+R C+ CP
Sbjct: 314 EWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCP 362
Score = 43.9 bits (102), Expect = 3e-04
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 8/52 (15%)
Query: 222 DWSLWSVCSVTCGNGNQKRTRSCGYA------CTA--TESRTCDRPNCPGIE 265
+W W CS +C NG Q+R+R C A CT T++R C CP +
Sbjct: 424 EWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATD 475
Score = 41.2 bits (95), Expect = 0.002
Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 8/49 (16%)
Query: 222 DWSLWSVCSVTCGNGNQKRTRSC------GYACTATESRT--CDRPNCP 262
+W WS+CS +CG G++ R R+C G AC E +T C CP
Sbjct: 369 EWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACP 417
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 45.8 bits (107), Expect = 8e-05
Identities = 40/158 (25%), Positives = 62/158 (39%), Gaps = 19/158 (12%)
Query: 192 PPRGWDHTAPGHRTFE-----TKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSC-- 244
PP APG F+ + Y G W+ + CS +CG G + R+RSC
Sbjct: 522 PPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNN 581
Query: 245 ------GYACTAT--ESRTCDRPNCPGIEDTFRT--AATEVSLLAGSEEFNATKLFEVDT 294
G C E + C+ CPG + FR A S ++ +E D
Sbjct: 582 PSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDD 641
Query: 295 DSCERWMSCKSEFLKK--YMHKVMNDLPSCPCSYPTEV 330
D+ + + C+S +M++V++D C P V
Sbjct: 642 DAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSV 679
Score = 31.2 bits (69), Expect = 2.1
Identities = 30/109 (27%), Positives = 42/109 (38%), Gaps = 21/109 (19%)
Query: 223 WSL--WSVCSVTCGNGNQKR-------TRSCGYACTATESRT---CDRPNCPGIE----- 265
W L WS CS TCG G Q+R S G+ C T C P C G
Sbjct: 972 WRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH-CEGDRPDTVQVCSLPACGGNHQNSTV 1030
Query: 266 --DTFRTAATEVSLLAGSEEFN-ATKLFEVDTDSCERWMSCKSEFLKKY 311
D + E + SE + K+ + + +R + C+ E L +Y
Sbjct: 1031 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRY 1079
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 45.8 bits (107), Expect = 8e-05
Identities = 40/158 (25%), Positives = 62/158 (39%), Gaps = 19/158 (12%)
Query: 192 PPRGWDHTAPGHRTFE-----TKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSC-- 244
PP APG F+ + Y G W+ + CS +CG G + R+RSC
Sbjct: 525 PPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNN 584
Query: 245 ------GYACTAT--ESRTCDRPNCPGIEDTFRT--AATEVSLLAGSEEFNATKLFEVDT 294
G C E + C+ CPG + FR A S ++ +E D
Sbjct: 585 PSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDD 644
Query: 295 DSCERWMSCKSEFLKK--YMHKVMNDLPSCPCSYPTEV 330
D+ + + C+S +M++V++D C P V
Sbjct: 645 DAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSV 682
Score = 31.2 bits (69), Expect = 2.1
Identities = 30/109 (27%), Positives = 42/109 (38%), Gaps = 21/109 (19%)
Query: 223 WSL--WSVCSVTCGNGNQKR-------TRSCGYACTATESRT---CDRPNCPGIE----- 265
W L WS CS TCG G Q+R S G+ C T C P C G
Sbjct: 975 WRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH-CEGDRPDTVQVCSLPACGGNHQNSTV 1033
Query: 266 --DTFRTAATEVSLLAGSEEFN-ATKLFEVDTDSCERWMSCKSEFLKKY 311
D + E + SE + K+ + + +R + C+ E L +Y
Sbjct: 1034 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRY 1082
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 45.8 bits (107), Expect = 8e-05
Identities = 22/50 (44%), Positives = 29/50 (58%), Gaps = 9/50 (18%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSCGYA--------CTATESRTCDRPNCPGI 264
WS WS C V+CG GNQ RTR+C A C +++T +P CPG+
Sbjct: 4259 WSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQP-CPGL 4307
Score = 44.7 bits (104), Expect = 2e-04
Identities = 24/58 (41%), Positives = 27/58 (46%), Gaps = 12/58 (20%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAG 280
W W CSV+CG G Q R SR C RP CPG RT +T+V AG
Sbjct: 3651 WGPWEDCSVSCGGGEQLR------------SRRCARPPCPGPARQSRTCSTQVCREAG 3696
Score = 42.7 bits (99), Expect = 7e-04
Identities = 34/122 (27%), Positives = 46/122 (37%), Gaps = 8/122 (6%)
Query: 146 ENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRT 205
E +P+WS W W Q S S A + S S + + P P
Sbjct: 3181 EGEPTWS----PWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSG 3236
Query: 206 FETKDQP----EYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNC 261
E +++P D G G W WS CS +CG G + RTR+C C+ P
Sbjct: 3237 PEAEEEPCLLQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRA 3296
Query: 262 PG 263
G
Sbjct: 3297 QG 3298
Score = 40.8 bits (94), Expect = 0.003
Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 10/62 (16%)
Query: 214 YDSTDGEGDWSLWSVCSVTCGN-GNQKRTRSC--------GYACTA-TESRTCDRPNCPG 263
+++ G G WS W CS +CG G + R+R C G C + C P+CPG
Sbjct: 3808 FEADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGPRQDLECPSPDCPG 3867
Query: 264 IE 265
E
Sbjct: 3868 AE 3869
Score = 40.0 bits (92), Expect = 0.004
Identities = 19/43 (44%), Positives = 23/43 (53%), Gaps = 2/43 (4%)
Query: 221 GDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPG 263
G+W WS CSV CG G + RTR G + + E TC C G
Sbjct: 3044 GEWGPWSPCSVPCGGGYRNRTR--GSSRSLMEFSTCGLQPCAG 3084
Score = 38.5 bits (88), Expect = 0.013
Identities = 23/50 (46%), Positives = 26/50 (52%), Gaps = 8/50 (16%)
Query: 221 GDWSLWSVCSVTCGNGNQKRTRSC----GYA-CTA--TESR-TCDRPNCP 262
G WS WS CS CG G +R R+C G A C A TE R C+ CP
Sbjct: 4767 GPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPCP 4816
Score = 37.7 bits (86), Expect = 0.022
Identities = 13/22 (59%), Positives = 15/22 (68%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSC 244
W W CSV+CG G+Q R RSC
Sbjct: 2561 WEAWGPCSVSCGGGHQSRQRSC 2582
Score = 37.4 bits (85), Expect = 0.029
Identities = 24/69 (34%), Positives = 28/69 (40%), Gaps = 3/69 (4%)
Query: 193 PRGWDHTAPGHRTFETKDQPEYDSTDGE-GDWSLWSVCSVTCGNGNQKRTRSCGYACTAT 251
P D + PG T E P G W+ WS CS C G Q R RSC + A
Sbjct: 2805 PSPGDSSCPGDATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSC--SSLAP 2862
Query: 252 ESRTCDRPN 260
TC P+
Sbjct: 2863 GDTTCPGPH 2871
Score = 37.0 bits (84), Expect = 0.038
Identities = 26/91 (28%), Positives = 36/91 (39%), Gaps = 8/91 (8%)
Query: 212 PEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTA 271
PE G WS W CS TCG Q R+R C + NCPG E +
Sbjct: 1689 PEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRC------SPLGLLVLQNCPGPEHQSQAC 1742
Query: 272 ATEVSLLAGSEEFNATKLFEVDTDSCERWMS 302
T + G E++ + V ++ C M+
Sbjct: 1743 FTAACPVDG--EWSTWSPWSVCSEPCRGTMT 1771
Score = 36.6 bits (83), Expect = 0.050
Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 8/48 (16%)
Query: 223 WSLWSVCSVTCG-NGNQKRTRSCGYACTATE-------SRTCDRPNCP 262
WS WS CS +CG G Q R RS A E S+ C +P+CP
Sbjct: 4165 WSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCP 4212
Score = 34.7 bits (78), Expect = 0.19
Identities = 19/50 (38%), Positives = 25/50 (50%), Gaps = 7/50 (14%)
Query: 219 GEGDWSLWSVCSVTCGN----GNQKRTRSCGYACT---ATESRTCDRPNC 261
G G WS WS CS +C + + RTR C CT + R C+ P+C
Sbjct: 3882 GWGPWSSWSPCSRSCTDPARPAWRSRTRLCLANCTMGDPLQERPCNLPSC 3931
Score = 33.5 bits (75), Expect = 0.42
Identities = 13/26 (50%), Positives = 15/26 (57%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC 244
G WS WS C +CG G R+RSC
Sbjct: 4006 GWSRWSPWSWCDRSCGGGQSLRSRSC 4031
Score = 32.3 bits (72), Expect = 0.94
Identities = 18/55 (32%), Positives = 25/55 (45%), Gaps = 10/55 (18%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRS--------CGYAC--TATESRTCDRPNCPG 263
G W+LWS+CS +C G ++R R+ G C E+ C CPG
Sbjct: 2987 GWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPG 3041
Score = 31.2 bits (69), Expect = 2.1
Identities = 25/85 (29%), Positives = 33/85 (38%), Gaps = 13/85 (15%)
Query: 191 NPPRGWDHTAPGHRTFETKDQPEYDSTD--GEGDWSLWSVCSVTC-----GNGNQKRTRS 243
NPP W E + T+ G W+ WS CS +C G G + R+R
Sbjct: 2744 NPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSRL 2803
Query: 244 C----GYAC--TATESRTCDRPNCP 262
C +C AT+ C P CP
Sbjct: 2804 CPSPGDSSCPGDATQEEPCSPPVCP 2828
Score = 31.2 bits (69), Expect = 2.1
Identities = 18/51 (35%), Positives = 23/51 (45%), Gaps = 11/51 (21%)
Query: 223 WSLWSVCSVTCGNGNQKRTRS----------CGYACTA-TESRTCDRPNCP 262
W+ W CS +CG G Q+R R+ C TA E R C+ CP
Sbjct: 3952 WAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNILTAYQERRFCNLRACP 4002
Score = 29.6 bits (65), Expect = 6.1
Identities = 16/48 (33%), Positives = 19/48 (39%), Gaps = 5/48 (10%)
Query: 223 WSLWSVCSVTCGNGNQKRTRS----CGYACTAT-ESRTCDRPNCPGIE 265
W WS C V C G + R R CG C +C+ CP E
Sbjct: 4621 WGPWSPCQVPCSGGFRLRWREAEALCGGGCREPWAQESCNGGPCPECE 4668
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/54 (42%), Positives = 25/54 (46%), Gaps = 10/54 (18%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC--------GYACTAT--ESRTCDRPNCP 262
G WS W CSVTCG G QKR+R C G C + E R C CP
Sbjct: 4531 GFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPCP 4584
Score = 43.1 bits (100), Expect = 5e-04
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 222 DWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCD 257
+WSLW C+ +CG GNQ RTR+C R C+
Sbjct: 4591 EWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCE 4626
Score = 40.0 bits (92), Expect = 0.004
Identities = 15/35 (42%), Positives = 20/35 (57%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCD 257
W+ WS CSV+CG G ++RTR C R C+
Sbjct: 4706 WASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCE 4740
Score = 40.0 bits (92), Expect = 0.004
Identities = 28/108 (25%), Positives = 40/108 (37%), Gaps = 8/108 (7%)
Query: 152 SVPSPDWRAW--WQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETK 209
S P P W W + +R +G Q +Y + + PP G + +
Sbjct: 4751 SDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNP-----PPSNGGRACGGPDSQIQR 4805
Query: 210 DQPEYDSTDGE-GDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTC 256
+ DG G W WS CS +CG G + R R C + R C
Sbjct: 4806 CNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPC 4853
Score = 38.5 bits (88), Expect = 0.013
Identities = 18/50 (36%), Positives = 22/50 (44%), Gaps = 10/50 (20%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSC--------GYAC--TATESRTCDRPNCP 262
W W CS +CG G Q R R C G C T+ + C+ NCP
Sbjct: 4649 WQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCP 4698
Score = 36.2 bits (82), Expect = 0.065
Identities = 14/38 (36%), Positives = 18/38 (47%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPN 260
WS W CS TC G +R R+C + R C P+
Sbjct: 4763 WSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPD 4800
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 45.1 bits (105), Expect = 1e-04
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 8/50 (16%)
Query: 222 DWSLWSVCSVTCGNGNQKRTRSC------GYACTATESRT--CDRPNCPG 263
+WS WS+CS TCG G + RTR+C G C E +T C+ CPG
Sbjct: 414 EWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPG 463
Score = 44.3 bits (103), Expect = 2e-04
Identities = 24/63 (38%), Positives = 31/63 (49%), Gaps = 9/63 (14%)
Query: 208 TKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSC-------GYACTAT--ESRTCDR 258
T+D+ + +T G WSLW C+ CG G Q RTR+C G C E R C+R
Sbjct: 252 TQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNR 311
Query: 259 PNC 261
C
Sbjct: 312 EAC 314
Score = 43.1 bits (100), Expect = 5e-04
Identities = 22/56 (39%), Positives = 27/56 (48%), Gaps = 9/56 (16%)
Query: 216 STDGE-GDWSLWSVCSVTCGNGNQKRTRSC------GYACTA--TESRTCDRPNCP 262
+ DG +WS WS CS +C G Q+RTR C G C E+R C CP
Sbjct: 465 AVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCP 520
Score = 42.7 bits (99), Expect = 7e-04
Identities = 36/116 (31%), Positives = 45/116 (38%), Gaps = 19/116 (16%)
Query: 157 DWRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQ-PEYD 215
+W W S A + G Q + N P GH ET+D +
Sbjct: 469 NWNEWSSWSACSASCSQGRQQRTREC--------NGPSYGGAECQGHWV-ETRDCFLQQC 519
Query: 216 STDGEGD-WSLWSVCSVTCGNGNQKRTRSC------GYACTA--TESRTCDRPNCP 262
DG+ W+ W CSVTCG G+Q+R R C G AC E R C CP
Sbjct: 520 PVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCP 575
Score = 40.8 bits (94), Expect = 0.003
Identities = 19/38 (50%), Positives = 23/38 (60%), Gaps = 3/38 (7%)
Query: 222 DWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRP 259
+WS WSVCS TCG G Q RTR C +++ S C P
Sbjct: 359 EWSPWSVCSSTCGEGWQTRTRFC---VSSSYSTQCSGP 393
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 44.3 bits (103), Expect = 2e-04
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 215 DSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACT-----ATESRTCDRPNC 261
D +G W+ W+ CSVTCG+G Q+R RSC + ++R C C
Sbjct: 379 DGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKC 430
Score = 42.0 bits (97), Expect = 0.001
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 10/50 (20%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSC--------GYACT--ATESRTCDRPNCP 262
WS WS C+VTC G ++RTR C G AC E + C++ +CP
Sbjct: 500 WSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCP 549
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/54 (40%), Positives = 25/54 (46%), Gaps = 10/54 (18%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC--------GYAC--TATESRTCDRPNCP 262
G WS WS CSVTCG GN R R C G C + E++ C CP
Sbjct: 439 GWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCP 492
>gi|145699139 cartilage intermediate layer protein 2 [Homo sapiens]
Length = 1156
Score = 42.7 bits (99), Expect = 7e-04
Identities = 21/49 (42%), Positives = 25/49 (51%), Gaps = 6/49 (12%)
Query: 221 GDWSLWSVCSVTCGNGNQKRTRSC----GYACTA--TESRTCDRPNCPG 263
G W W CS +CG G + R R C G AC E++ C RP CPG
Sbjct: 150 GAWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPG 198
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 42.0 bits (97), Expect = 0.001
Identities = 20/50 (40%), Positives = 23/50 (46%), Gaps = 10/50 (20%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSCGYACTA----------TESRTCDRPNCP 262
WS W+ CS TCG G+ RTRSC A TE C+ CP
Sbjct: 847 WSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCP 896
Score = 38.1 bits (87), Expect = 0.017
Identities = 21/62 (33%), Positives = 23/62 (37%), Gaps = 6/62 (9%)
Query: 195 GWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESR 254
GW PG + G W+ WS CS TCG G Q R RSC R
Sbjct: 579 GWQCEGPG------MEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGR 632
Query: 255 TC 256
C
Sbjct: 633 VC 634
Score = 34.7 bits (78), Expect = 0.19
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 4/49 (8%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSC--GYACTA--TESRTCDRPNCPGIEDT 267
W W C+ CG G Q R R C G C E ++C+ CP ++ T
Sbjct: 659 WGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKT 707
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 42.0 bits (97), Expect = 0.001
Identities = 19/46 (41%), Positives = 24/46 (52%), Gaps = 4/46 (8%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSC--GYAC--TATESRTCDRPNCPGI 264
W WS CS CG G Q R R+C G +C E +TC+ CP +
Sbjct: 728 WGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEV 773
Score = 38.5 bits (88), Expect = 0.013
Identities = 18/50 (36%), Positives = 23/50 (46%), Gaps = 10/50 (20%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSCGYACTA----------TESRTCDRPNCP 262
W+ WS CS +CG G+ +RTRSC + TE C CP
Sbjct: 916 WTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACP 965
Score = 37.0 bits (84), Expect = 0.038
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSCGYACTATESRTC 256
WS W++CS +CG G Q R RSC R C
Sbjct: 670 WSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRIC 703
Score = 29.6 bits (65), Expect = 6.1
Identities = 18/54 (33%), Positives = 22/54 (40%), Gaps = 10/54 (18%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC--------GYACT--ATESRTCDRPNCP 262
G W WS CS C G + R R+C G C A E + C+ CP
Sbjct: 855 GWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACP 908
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
motif, 19 preproprotein [Homo sapiens]
Length = 1207
Score = 41.6 bits (96), Expect = 0.002
Identities = 32/97 (32%), Positives = 36/97 (37%), Gaps = 29/97 (29%)
Query: 202 GHRTFETKDQPEYDSTD---------GE------------GDWSLWSVCSVTCGNGNQKR 240
G + TK P D TD GE G+WSLWS CS TC G R
Sbjct: 597 GEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSR 656
Query: 241 TRSC-GYACTATES-------RTCDRPNCPGIEDTFR 269
R C G A + R C+ P CP FR
Sbjct: 657 ERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFR 693
Score = 34.7 bits (78), Expect = 0.19
Identities = 13/31 (41%), Positives = 15/31 (48%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACTATESRTC 256
WS CS+TCG G Q R C + T C
Sbjct: 1096 WSKCSITCGKGMQSRVIQCMHKITGRHGNEC 1126
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 41.6 bits (96), Expect = 0.002
Identities = 28/79 (35%), Positives = 34/79 (43%), Gaps = 14/79 (17%)
Query: 200 APGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSC-------GYACT--A 250
APG + + Q +D G WS WS CS TCG G R R C G +C A
Sbjct: 14 APGSSAPKVRRQ-----SDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPA 68
Query: 251 TESRTCDRPNCPGIEDTFR 269
R+C +CP FR
Sbjct: 69 RSHRSCRTESCPDGARDFR 87
Score = 30.0 bits (66), Expect = 4.6
Identities = 12/39 (30%), Positives = 19/39 (48%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGI 264
W+ CS +CG G+Q R+ C + A + C G+
Sbjct: 344 WAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGL 382
Score = 29.6 bits (65), Expect = 6.1
Identities = 14/37 (37%), Positives = 15/37 (40%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCP 262
WS CS CG G+Q R C A C R P
Sbjct: 286 WSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRP 322
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 41.2 bits (95), Expect = 0.002
Identities = 31/92 (33%), Positives = 39/92 (42%), Gaps = 14/92 (15%)
Query: 192 PPRGWDHTAPGHRTFETKD---QPEYDSTDGE-GDWSLWSVCSVTCGNGNQKRTRSC--- 244
PP APG F+ P+ DG G WS + CS TCG G + RTR C
Sbjct: 532 PPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNP 591
Query: 245 -----GYACT--ATESRTCDRPNCPGIEDTFR 269
G C+ A + + C R +CP FR
Sbjct: 592 HPANGGRTCSGLAYDFQLCSRQDCPDSLADFR 623
Score = 41.2 bits (95), Expect = 0.002
Identities = 34/151 (22%), Positives = 60/151 (39%), Gaps = 24/151 (15%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACTA---------TESRTCDRPNCP-GIEDTFRTAATEV 275
WS CSVTCGNG Q+R C A + +RTC CP I D + +
Sbjct: 984 WSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQ 1043
Query: 276 SLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYMHKVMNDLPSCPCSYP--TEVAYS 333
L + K+ ++ + C+ E L +Y CS P ++
Sbjct: 1044 WLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRY------------CSIPGYNKLCCK 1091
Query: 334 TADIFDRIKRKDFRWKDASGPKEKLEIYKPT 364
+ ++++ + + R + G ++++ PT
Sbjct: 1092 SCNLYNNLTNVEGRIEPPPGKHNDIDVFMPT 1122
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 40.0 bits (92), Expect = 0.004
Identities = 28/96 (29%), Positives = 38/96 (39%), Gaps = 13/96 (13%)
Query: 220 EGDWS---LWSVCSVTCGNGNQKRTRSC--------GYAC--TATESRTCDRPNCPGIED 266
+GDWS WS+CS TCG G + R R C G C + E C+ CP
Sbjct: 543 DGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLP 602
Query: 267 TFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMS 302
+FR + ++ VD CE + S
Sbjct: 603 SFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCS 638
Score = 36.6 bits (83), Expect = 0.050
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 4/69 (5%)
Query: 196 WDHTAPGHRTFETKDQPEYDSTDGEGDW--SLWSVCSVTCGNGNQKRTRSCGYACTATES 253
+++T P +RT E + +PE D W S W CSV CG G ++ SC T +
Sbjct: 778 YEYTVPVNRTAENQSEPEKPQ-DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTT 836
Query: 254 RTCDRPNCP 262
D +CP
Sbjct: 837 LVND-SDCP 844
Score = 32.7 bits (73), Expect = 0.72
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 5/43 (11%)
Query: 224 SLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIED 266
S WS CS +CG G KRT ACT ++ + CD P E+
Sbjct: 928 SEWSQCSASCGKGVWKRT----VACTNSQGK-CDASTRPRAEE 965
Score = 32.7 bits (73), Expect = 0.72
Identities = 13/31 (41%), Positives = 14/31 (45%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACTATESRTC 256
WS CS TCG G Q R C + T C
Sbjct: 981 WSTCSSTCGKGLQSRVVQCMHKVTGRHGSEC 1011
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 39.7 bits (91), Expect = 0.006
Identities = 15/26 (57%), Positives = 18/26 (69%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC 244
G W+ WSVC+ CG G QKRTR+C
Sbjct: 262 GWSTWTEWSVCNSRCGRGYQKRTRTC 287
>gi|10092665 sushi domain containing 2 [Homo sapiens]
Length = 822
Score = 39.7 bits (91), Expect = 0.006
Identities = 40/160 (25%), Positives = 61/160 (38%), Gaps = 30/160 (18%)
Query: 297 CERWMSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKE 356
C+ W E L+ + + +LP CPC+ T+ + F D+ G
Sbjct: 293 CQAW-----EELEDQLPNFLEELPDCPCTL-TQARADSGRFFT-----DYGCDMEQG--- 338
Query: 357 KLEIYKPTARYCIRSMLSLESTTLAAQHCCY-GDNMQLITRGKGAGT-----------PN 404
+ Y P A +C+RS + + Q CCY D QL+T G+ P
Sbjct: 339 SVCTYHPGAVHCVRS-VQASLRYGSGQQCCYTADGTQLLTADSSGGSTPDRGHDWGAPPF 397
Query: 405 LISTEFSAELHYKVDVLPWIIC---KGDWSRYNEARPPNN 441
+ H+ DVL + C D RY + RP N+
Sbjct: 398 RTPPRVPSMSHWLYDVLSFYYCCLWAPDCPRYMQRRPSND 437
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 39.3 bits (90), Expect = 0.008
Identities = 22/60 (36%), Positives = 26/60 (43%), Gaps = 10/60 (16%)
Query: 222 DWSLWSVCSVTCGNGNQKRTRSC--------GYACTATES--RTCDRPNCPGIEDTFRTA 271
DWS WS CS TCG G R+R C G C + + C+ CP FR A
Sbjct: 591 DWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAA 650
Score = 32.3 bits (72), Expect = 0.94
Identities = 15/38 (39%), Positives = 17/38 (44%)
Query: 224 SLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNC 261
S WS CSVTC G QKR C + + R C
Sbjct: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKC 1095
Score = 31.2 bits (69), Expect = 2.1
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 6/43 (13%)
Query: 223 WSL--WSVCSVTCGNGNQKR----TRSCGYACTATESRTCDRP 259
WS+ WS CS TCG G Q R TR Y + C +P
Sbjct: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQP 973
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 38.9 bits (89), Expect = 0.010
Identities = 36/128 (28%), Positives = 49/128 (38%), Gaps = 25/128 (19%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC--------GYACTA--TESRTCDRPNCP-GIEDT 267
G G W W CS TCG G Q +R C G C T R+C+ +CP G T
Sbjct: 522 GWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALT 581
Query: 268 FRTAATEVSLLAGSEEFNATKLFEVDTDSCERW----------MSCKSEFLKKYMHKVMN 317
FR E A + + K F D R+ ++C+++ L Y
Sbjct: 582 FR----EEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPR 637
Query: 318 DLPSCPCS 325
+ PCS
Sbjct: 638 VVDGTPCS 645
>gi|189242612 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 38.5 bits (88), Expect = 0.013
Identities = 17/51 (33%), Positives = 23/51 (45%), Gaps = 11/51 (21%)
Query: 223 WSLWSVCSVTCGNGNQKRTRS-----------CGYACTATESRTCDRPNCP 262
W+ W+ CS TC +G Q R R C C+ E+R C+ CP
Sbjct: 29 WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCP 79
Score = 37.4 bits (85), Expect = 0.029
Identities = 37/163 (22%), Positives = 60/163 (36%), Gaps = 11/163 (6%)
Query: 209 KDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTF 268
K P+Y S +G W WS S + RTR C + C+ + TF
Sbjct: 554 KQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTF 613
Query: 269 RTAATE-VSLLAGSEEFNATKLFEVDTDS-CERWMSCKSEFLK--KYMHKVMNDLP-SCP 323
+ EE L E++ DS C + + ++ F++ K ++ V D+ SC
Sbjct: 614 SIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCL 673
Query: 324 CSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTAR 366
+ T V Y D W+ ++ E KP +
Sbjct: 674 TGFET-VGYQYFRCL-----PDGTWRQGDVECQRTECIKPVVQ 710
>gi|169636415 complement component 6 precursor [Homo sapiens]
Length = 934
Score = 38.5 bits (88), Expect = 0.013
Identities = 17/51 (33%), Positives = 23/51 (45%), Gaps = 11/51 (21%)
Query: 223 WSLWSVCSVTCGNGNQKRTRS-----------CGYACTATESRTCDRPNCP 262
W+ W+ CS TC +G Q R R C C+ E+R C+ CP
Sbjct: 29 WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCP 79
Score = 37.4 bits (85), Expect = 0.029
Identities = 37/163 (22%), Positives = 60/163 (36%), Gaps = 11/163 (6%)
Query: 209 KDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTF 268
K P+Y S +G W WS S + RTR C + C+ + TF
Sbjct: 554 KQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTF 613
Query: 269 RTAATE-VSLLAGSEEFNATKLFEVDTDS-CERWMSCKSEFLK--KYMHKVMNDLP-SCP 323
+ EE L E++ DS C + + ++ F++ K ++ V D+ SC
Sbjct: 614 SIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCL 673
Query: 324 CSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTAR 366
+ T V Y D W+ ++ E KP +
Sbjct: 674 TGFET-VGYQYFRCL-----PDGTWRQGDVECQRTECIKPVVQ 710
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 38.5 bits (88), Expect = 0.013
Identities = 23/60 (38%), Positives = 26/60 (43%), Gaps = 5/60 (8%)
Query: 215 DSTDGEGD-WSLWSVCSVTCGNGNQKRTRSC--GYACTATESR--TCDRPNCPGIEDTFR 269
+ DG D W WS CS TCG G R C G C R TC +CP + FR
Sbjct: 72 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFR 131
Score = 34.7 bits (78), Expect = 0.19
Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 6/43 (13%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACTATESRT------CDRPNCP 262
WS CS TCG G Q R C T T++ T C+ P P
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP 615
Score = 32.0 bits (71), Expect = 1.2
Identities = 26/92 (28%), Positives = 37/92 (40%), Gaps = 23/92 (25%)
Query: 200 APGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSC------GYACTATES 253
A H++ D P + + GDWS CSV+CG G Q+R + C G +E
Sbjct: 808 ASSHKSCARTDCPPHLAV---GDWSK---CSVSCGVGIQRRKQVCQRLAAKGRRIPLSEM 861
Query: 254 -----------RTCDRPNCPGIEDTFRTAATE 274
R+C P C I+ +T E
Sbjct: 862 MCRDLPGLPLVRSCQMPECSKIKSEMKTKLGE 893
Score = 31.2 bits (69), Expect = 2.1
Identities = 16/53 (30%), Positives = 21/53 (39%), Gaps = 16/53 (30%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACT----------------ATESRTCDRPNCP 262
W CS TCG G Q R +C T A+ ++C R +CP
Sbjct: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCP 820
Score = 30.0 bits (66), Expect = 4.6
Identities = 11/21 (52%), Positives = 14/21 (66%)
Query: 224 SLWSVCSVTCGNGNQKRTRSC 244
S+WS CSV+CG G R +C
Sbjct: 1490 SVWSQCSVSCGEGYHSRQVTC 1510
Score = 29.6 bits (65), Expect = 6.1
Identities = 10/19 (52%), Positives = 14/19 (73%)
Query: 226 WSVCSVTCGNGNQKRTRSC 244
W+ CSV+CG G Q+R+ C
Sbjct: 427 WTACSVSCGGGIQRRSFVC 445
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 38.5 bits (88), Expect = 0.013
Identities = 21/61 (34%), Positives = 25/61 (40%), Gaps = 10/61 (16%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC--------GYACTATES--RTCDRPNCPGIEDTF 268
G WS WS+CS +CG G Q R C G C R C+ CP +F
Sbjct: 540 GWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSF 599
Query: 269 R 269
R
Sbjct: 600 R 600
Score = 35.4 bits (80), Expect = 0.11
Identities = 18/42 (42%), Positives = 19/42 (45%), Gaps = 4/42 (9%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDT 267
WS CSVTCG G Q+R CT CD P E T
Sbjct: 951 WSQCSVTCGEGTQRR----NVLCTNDTGVPCDEAQQPASEVT 988
>gi|209977117 unc-5 homolog D [Homo sapiens]
Length = 953
Score = 38.5 bits (88), Expect = 0.013
Identities = 14/26 (53%), Positives = 18/26 (69%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSC 244
G W+ WS C+V CG G QKR+R+C
Sbjct: 254 GWSSWTEWSACNVRCGRGWQKRSRTC 279
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/86 (30%), Positives = 33/86 (38%), Gaps = 18/86 (20%)
Query: 195 GWD-----HTAPGHRTFETK---DQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGY 246
GW+ APG ++ + DQ G W W CSVTC G + R R+C +
Sbjct: 106 GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNH 165
Query: 247 AC---------TATESRTCDRPN-CP 262
A ES CD CP
Sbjct: 166 PAPKCGGHCPGQAQESEACDTQQVCP 191
Score = 35.8 bits (81), Expect = 0.085
Identities = 13/22 (59%), Positives = 15/22 (68%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSC 244
WS W+ CSVTC G+Q R R C
Sbjct: 83 WSTWAPCSVTCSEGSQLRYRRC 104
Score = 29.3 bits (64), Expect = 7.9
Identities = 22/81 (27%), Positives = 34/81 (41%), Gaps = 10/81 (12%)
Query: 194 RGWDHTAP---GHRTFETKDQPEYDS-----TDGE-GDWSLWSVCSVTCGNGNQKRTRSC 244
R +H AP GH + ++ D+ T G W W+ CS +C G + +
Sbjct: 161 RACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETR 220
Query: 245 GYACTATE-SRTCDRPNCPGI 264
C+A E S+ CPG+
Sbjct: 221 SRKCSAPEPSQKPPGKPCPGL 241
Score = 29.3 bits (64), Expect = 7.9
Identities = 12/28 (42%), Positives = 14/28 (50%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSCGY 246
G G W S C VTCG G R+C +
Sbjct: 259 GWGPWGPVSPCPVTCGLGQTMEQRTCNH 286
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 38.1 bits (87), Expect = 0.017
Identities = 26/86 (30%), Positives = 33/86 (38%), Gaps = 18/86 (20%)
Query: 195 GWD-----HTAPGHRTFETK---DQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGY 246
GW+ APG ++ + DQ G W W CSVTC G + R R+C +
Sbjct: 106 GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNH 165
Query: 247 AC---------TATESRTCDRPN-CP 262
A ES CD CP
Sbjct: 166 PAPKCGGHCPGQAQESEACDTQQVCP 191
Score = 35.8 bits (81), Expect = 0.085
Identities = 13/22 (59%), Positives = 15/22 (68%)
Query: 223 WSLWSVCSVTCGNGNQKRTRSC 244
WS W+ CSVTC G+Q R R C
Sbjct: 83 WSTWAPCSVTCSEGSQLRYRRC 104
Score = 29.3 bits (64), Expect = 7.9
Identities = 22/81 (27%), Positives = 34/81 (41%), Gaps = 10/81 (12%)
Query: 194 RGWDHTAP---GHRTFETKDQPEYDS-----TDGE-GDWSLWSVCSVTCGNGNQKRTRSC 244
R +H AP GH + ++ D+ T G W W+ CS +C G + +
Sbjct: 161 RACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETR 220
Query: 245 GYACTATE-SRTCDRPNCPGI 264
C+A E S+ CPG+
Sbjct: 221 SRKCSAPEPSQKPPGKPCPGL 241
Score = 29.3 bits (64), Expect = 7.9
Identities = 12/28 (42%), Positives = 14/28 (50%)
Query: 219 GEGDWSLWSVCSVTCGNGNQKRTRSCGY 246
G G W S C VTCG G R+C +
Sbjct: 259 GWGPWGPVSPCPVTCGLGQTMEQRTCNH 286
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 37.7 bits (86), Expect = 0.022
Identities = 35/116 (30%), Positives = 44/116 (37%), Gaps = 11/116 (9%)
Query: 154 PSPDWRAW-WQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQP 212
P WRA WQ G + K D+ N ++ R P R +
Sbjct: 1555 PLYTWRAEEWQECTKTC--GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Query: 213 EYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRP---NCPGIE 265
EY GE WS CSVTCG G ++R SC T E+ NCPG +
Sbjct: 1613 EYVWITGE-----WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQ 1663
Score = 36.2 bits (82), Expect = 0.065
Identities = 31/107 (28%), Positives = 38/107 (35%), Gaps = 20/107 (18%)
Query: 175 DQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKD------QPEYDSTDGEGDWSL--W 226
DQDY ++ D S P R D H F+ +D P G W W
Sbjct: 1279 DQDYIPETDQDCSMSPCPQRTPDSGLAQH-PFQNEDYRPRSASPSRTHVLGGNQWRTGPW 1337
Query: 227 SVCSVTCGNGNQKRTRSC----GYACT-------ATESRTCDRPNCP 262
CS TC G+Q+R C GY E R C+ CP
Sbjct: 1338 GACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
Score = 34.7 bits (78), Expect = 0.19
Identities = 24/83 (28%), Positives = 33/83 (39%), Gaps = 21/83 (25%)
Query: 205 TFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRT--------------RSCGYACTA 250
+ +T QPE S W CSVTCG G Q R C A
Sbjct: 1099 SMQTCQQPECASWQA----GPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRP 1154
Query: 251 TESRTCDRPNC---PGIEDTFRT 270
T+++ C+ P+C P +T R+
Sbjct: 1155 TDTQDCELPSCHPPPAAPETRRS 1177
Score = 33.1 bits (74), Expect = 0.55
Identities = 17/45 (37%), Positives = 20/45 (44%), Gaps = 3/45 (6%)
Query: 221 GDWSL--WSVCSVTCGNGNQKRTRSC-GYACTATESRTCDRPNCP 262
G W WS CSVTCG G R C Y+ + CD+ P
Sbjct: 1240 GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
Score = 32.7 bits (73), Expect = 0.72
Identities = 16/48 (33%), Positives = 20/48 (41%), Gaps = 12/48 (25%)
Query: 226 WSVCSVTCGNGNQKR------------TRSCGYACTATESRTCDRPNC 261
WS C VTCG G++ R R C T +TC +P C
Sbjct: 1061 WSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Score = 32.0 bits (71), Expect = 1.2
Identities = 19/50 (38%), Positives = 21/50 (42%), Gaps = 13/50 (26%)
Query: 226 WSVCSVTCGNGNQKRTRSCGYAC------------TATES-RTCDRPNCP 262
WS CSV+CG G Q+R C T ES R C P CP
Sbjct: 1506 WSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Score = 31.2 bits (69), Expect = 2.1
Identities = 14/29 (48%), Positives = 16/29 (55%), Gaps = 1/29 (3%)
Query: 217 TDGE-GDWSLWSVCSVTCGNGNQKRTRSC 244
TDG G WS + CS TCG G + R C
Sbjct: 587 TDGSWGSWSPFGTCSRTCGGGIKTAIREC 615
Score = 29.6 bits (65), Expect = 6.1
Identities = 12/24 (50%), Positives = 16/24 (66%), Gaps = 2/24 (8%)
Query: 223 WSL--WSVCSVTCGNGNQKRTRSC 244
WS WS CSV+CG G+++R C
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYC 1468
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,619,450
Number of Sequences: 37866
Number of extensions: 1012162
Number of successful extensions: 2781
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 2469
Number of HSP's gapped (non-prelim): 332
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.