Search of human proteins with 15147330

Search of human proteins with 15147330

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide
7 isoform 1 [Homo sapiens]
         (494 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   993   0.0  
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   935   0.0  
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   914   0.0  
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   857   0.0  
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   530   e-150
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   499   e-141
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   498   e-141
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   491   e-139
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   487   e-138
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   486   e-137
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   458   e-129
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   455   e-128
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   432   e-121
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   375   e-104
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   311   9e-85
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   302   5e-82
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   297   1e-80
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   297   2e-80
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   263   3e-70
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   243   2e-64
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   207   2e-53
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   207   2e-53
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  185   9e-47
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   149   6e-36
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   121   1e-27
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   119   6e-27
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   113   5e-25
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   112   6e-25
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   108   9e-24
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   105   9e-23

>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  993 bits (2567), Expect = 0.0
 Identities = 494/494 (100%), Positives = 494/494 (100%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
           FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN
Sbjct: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120

Query: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180
           GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240
           VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  935 bits (2416), Expect = 0.0
 Identities = 463/494 (93%), Positives = 480/494 (97%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASG+LLVALL CLTVMVLMSVWQQRKS+GKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
            SE YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGV FSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120

Query: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180
           GERAKQL RF+IATLRDFGVGKRGIEERIQEE+GFLI+A+R T GANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240
           VISSIVFGDRFDY+DKEFLSLL MMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF+L
Sbjct: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLFI
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360
            GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPYMEAVIHEIQ
Sbjct: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEV+PMLGSVLRDPSFFSNPQDFNPQHFL++K
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV F
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  914 bits (2363), Expect = 0.0
 Identities = 452/494 (91%), Positives = 470/494 (95%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASGLLLV LLACLTVMVLMSVW+QRKSRGKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
            SE YGPVFTIHLGPRRVVVLCGHDAV+EALVDQAEEFSGRGEQATFDW+FKGYGVAFSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120

Query: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180
           GERAKQL RF+IATLR FGVGKRGIEERIQEE+GFLI+A+R THGANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240
           VISSIVFGDRFDYEDKEFLSLL MMLG FQFT+TSTGQLYEMFSSVMKHLPGPQQQAFK 
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLF 
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPY EAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420
           RFGD++PM LA RV KDTKFRDFFLPKGTEVFPMLGSVLRDP FFSNP+DFNPQHFLD K
Sbjct: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480
           GQFKKSDAFVPFSIGKR CFGEGLARMELFLFFTT+MQNFR KS QSPKDIDVSPKHV F
Sbjct: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  857 bits (2215), Expect = 0.0
 Identities = 441/494 (89%), Positives = 442/494 (89%), Gaps = 51/494 (10%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
            S+                                                   GVAFSN
Sbjct: 61  VSQ---------------------------------------------------GVAFSN 69

Query: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180
           GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN
Sbjct: 70  GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 129

Query: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240
           VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL
Sbjct: 130 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 189

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI
Sbjct: 190 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 249

Query: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360
           AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ
Sbjct: 250 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 309

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK
Sbjct: 310 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 369

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF
Sbjct: 370 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 429

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 430 ATIPRNYTMSFLPR 443


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  530 bits (1365), Expect = e-150
 Identities = 253/489 (51%), Positives = 350/489 (71%)

Query: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECY 65
           L ++  LA LT ++L+ V +   +  +LPPGP PLP +GN LQ++   +  S ++F E Y
Sbjct: 3   LSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKY 62

Query: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAK 125
           G VFT+HLGPR VV+LCG +A+REALVD+AE FSGRG+ A  D  F+GYGV F+NG R K
Sbjct: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWK 122

Query: 126 QLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSI 185
            L RF++ T+RDFG+GKR +EERIQEE+  LIE +R + GA +DPTF      +N+I SI
Sbjct: 123 VLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSI 182

Query: 186 VFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLE 245
           VFG RF Y+D+EFL +L++    F   S+  GQL+E+FS  +K+ PG  +Q +K LQ + 
Sbjct: 183 VFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEIN 242

Query: 246 DFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTET 305
            +I   VE ++ TLDP++P+D ID++L+HM++E+ N ++EF  +NL ++TL+LF AGTET
Sbjct: 243 AYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTET 302

Query: 306 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV 365
            STTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DR KMPY EAVI+EIQRF D+
Sbjct: 303 TSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDL 362

Query: 366 IPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKK 425
           +PM +   V + T FR + +PK TEVF +L + L DP +F  P  FNP HFLD  G  KK
Sbjct: 363 LPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422

Query: 426 SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPR 485
           ++AF+PFS+GKR C GEG+AR ELFLFFTT++QNF + S  +P+DID++P+      IP 
Sbjct: 423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPP 482

Query: 486 NYTMSFLPR 494
            Y + FLPR
Sbjct: 483 TYQIRFLPR 491


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  499 bits (1286), Expect = e-141
 Identities = 245/485 (50%), Positives = 338/485 (69%)

Query: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVF 69
           A+L  L  +V + +    + +GKLPPGP PL  +GN L L ++ +  S+ K S+ YG ++
Sbjct: 7   AILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66

Query: 70  TIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLR 129
           T+HLGPRRVVVL G+ AV+EALVDQ EEFSGRG+   F    KG G+AFS+G+R K L +
Sbjct: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126

Query: 130 FAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGD 189
           F+I  LR+FG+GKR IEERI EE  FL+  +R T G   DPTF LSR+VSN+I S++FG 
Sbjct: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186

Query: 190 RFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIA 249
           RFDY+D+  L+++ ++   FQ  S+  G+LY++F S++  +PGP Q+ F+  + L D IA
Sbjct: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246

Query: 250 KKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTT 309
             V  +Q +LDP SP+DFI  FL  M EE+++P + F++  L+M+T NL   GT+TVSTT
Sbjct: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306

Query: 310 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMS 369
           L + FL LMK+P+V+A+V EEID V+G+ R P  +DR  MPY +AVIHE+QRF D+IPM+
Sbjct: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366

Query: 370 LARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAF 429
           L  RV +DT FR F +PKGT+V  +L +V  DPS F  PQ+FNP+HFLD    FKKS AF
Sbjct: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426

Query: 430 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTM 489
           +PFS G+R C GE LARMELFL+ T ++Q+F L+   +P+DID++P       +PR + +
Sbjct: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486

Query: 490 SFLPR 494
              PR
Sbjct: 487 CLRPR 491


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  498 bits (1282), Expect = e-141
 Identities = 243/485 (50%), Positives = 340/485 (70%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68
           V L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ++ + +  S+   S+ YGPV
Sbjct: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128
           FT++ G  R+VVL G++ V+EAL+D  EEFSGRG     +   +G+G+ FSNG+R K++ 
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124

Query: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184

Query: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248
            RFDY+D++FL+L+  +    +  ST   Q+   F +++ + PG   +  K L  +E  I
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244

Query: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308
            +KV+ +Q ++D N+P+DFID FLI M++E++N  +EF ++NL+++  +L  AGTET ST
Sbjct: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPY +AV+HE+QR+ D+IP 
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364

Query: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428
           SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P+HFLD+ G FKKS+ 
Sbjct: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF T ++QNF LKS   PKD+D +P    FA++P  Y 
Sbjct: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 LCFIP 489


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  491 bits (1263), Expect = e-139
 Identities = 237/485 (48%), Positives = 338/485 (69%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+  FS+ YGPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G+ FSNG+R K++ 
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248
           DRFDY+D+ FL+L+       +  S+   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244

Query: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308
            ++++ +Q +LD NS +DFID FLI M++E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364

Query: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 LCFIP 489


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  487 bits (1254), Expect = e-138
 Identities = 239/485 (49%), Positives = 329/485 (67%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68
           V L+ CL+ M+L S+W+Q   R KLPPGPTPLP IGN LQ++ + IC S   FS+ YGPV
Sbjct: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128
           FT++ G   +VV  G++AV+EAL+D  EEFSGRG       + KG G+  SNG+R K++ 
Sbjct: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124

Query: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI S+VF 
Sbjct: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184

Query: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248
            RFDY+D+ FL+L+      F+  ++   Q+   F  ++   PG   +  K +     +I
Sbjct: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244

Query: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308
            +KV+ +Q +LD N+P+DFID FLI M++E+ N  +EF ++NL+ +  +LF+AGTET ST
Sbjct: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364

Query: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428
            +   V  DTKFR++ +PKGT +  +L SVL D   F NP  F+P HFLD  G FKKSD 
Sbjct: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS    K+++ +       ++P +Y 
Sbjct: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 ICFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  486 bits (1252), Expect = e-137
 Identities = 238/486 (48%), Positives = 339/486 (69%)

Query: 8   LVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGP 67
           LV L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ+  + I  S+   S+ YGP
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63

Query: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQL 127
           VFT++ G + +VVL G++AV+EAL+D  EEFSGRG     +   +G+G+ FSNG++ K++
Sbjct: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123

Query: 128 LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 187
            RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183

Query: 188 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 247
             RFDY+D++FL+L+  +    +  S+   Q+   FS ++ + PG   +  K +  ++ +
Sbjct: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243

Query: 248 IAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVS 307
           I +KV+ +Q ++D N+PQDFID FL+ M++E+ N  +EF +++L  + ++LF AGTET S
Sbjct: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303

Query: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIP 367
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPY +AV+HE+QR+ D++P
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363

Query: 368 MSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSD 427
            SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P HFLD+ G FKKS 
Sbjct: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423

Query: 428 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNY 487
            F+PFS GKR C GE LA MELFLF T+++QNF LKS   PK++D +P    FA++P  Y
Sbjct: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483

Query: 488 TMSFLP 493
            + F+P
Sbjct: 484 QLCFIP 489


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  458 bits (1179), Expect = e-129
 Identities = 225/486 (46%), Positives = 324/486 (66%), Gaps = 1/486 (0%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68
           VALL     ++L+S+W+Q  S   LPPGP PLP IGN  QL  ++I  S  + ++ +GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128
           FT+++G +R+VV+ G+ AV+EAL+D  +EFSGRG+   F    +  G+ F+NG   K + 
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIR 126

Query: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188
           RF++ TLR++G+GK+G E RIQ E+ FL+EA+R T G   DPTF +     NVI+ I+F 
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248
             FDY D++FL L+ +    F   ST   QLY  F S + +LPG  ++  K +  +++++
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308
           +++V+ + ++LDPN P+D  D  L+ M++E+ +    + +  + ++  +LF AGTET ST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPYM+AV+HEIQRF  ++P 
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428
           +L     +DT FR + +PKGT V P L SVL D   F +P+ F P+HFL++ G+FK SD 
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488
           F PFS GKR C GEGLARMELFL    ++Q+F LK    PKDID+SP H+ F  IP  Y 
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 489 MSFLPR 494
           +  +PR
Sbjct: 487 LCVIPR 492


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  455 bits (1171), Expect = e-128
 Identities = 233/487 (47%), Positives = 324/487 (66%), Gaps = 3/487 (0%)

Query: 10  ALLACLTVMVLMSV-WQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68
           ALL  L +++L+++     ++RG LPPGPTPLP +GN LQL    +   +M+ S+ YGPV
Sbjct: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67

Query: 69  FTIHLGP-RRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQL 127
           FTI+LGP R VVVL G +AVREAL  QAEEFSGRG  A  +  F G+GV FSNGER +QL
Sbjct: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127

Query: 128 LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVF 187
            +F +  LRD G+GKR  EE IQ E+  L+E  + T G   DP+  L++  SNV+ S++F
Sbjct: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187

Query: 188 GDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDF 247
           G RF YEDKEF +++    G     S+  GQ YEMFS  ++ LPGP +Q    +  L  F
Sbjct: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247

Query: 248 IAKKVEHNQRTLDPNSP-QDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETV 306
             ++V+ +Q  LD + P +D +D+FL+ M +EE+NP TEF  KN++M+ + L  AGT TV
Sbjct: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307

Query: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVI 366
           STT+ Y  LLLMK+P V+  V EE++R +G  + P   DRT++PY +AV+HE QR   ++
Sbjct: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367

Query: 367 PMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKS 426
           PM + R + + T+FR + LP+GTEVFP+LGS+L DP+ F +P++FNP  FLD  G+F+K 
Sbjct: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427

Query: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRN 486
           +AF+PFS+GKR C GEGLA+ ELFLFFTT++Q F L+S   P  + + P       IP  
Sbjct: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487

Query: 487 YTMSFLP 493
           + +   P
Sbjct: 488 FQLQVRP 494


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  432 bits (1110), Expect = e-121
 Identities = 223/485 (45%), Positives = 305/485 (62%), Gaps = 59/485 (12%)

Query: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68
           VAL+ CL+ + L+S+W+Q   RG+LP GPTPLP IGN LQL+ + +  S+  FS+ YGPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G+ FSNG+R K++ 
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188
           RF + TLR+FG+GKR IE+R+QEE+  L+E +R T+ +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248
           DRFDY+D+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214

Query: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308
                                        E+ N  +EF +++L+ +  ++F AGTET ST
Sbjct: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305

Query: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFLD  G FKKSD 
Sbjct: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425

Query: 489 MSFLP 493
           + F+P
Sbjct: 426 LCFIP 430


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  375 bits (964), Expect = e-104
 Identities = 191/459 (41%), Positives = 286/459 (62%), Gaps = 1/459 (0%)

Query: 11  LLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFT 70
           LL      +L + + +R+     PPGP  LPF+GN+  ++ E     +  F + YG +F+
Sbjct: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80

Query: 71  IHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRF 130
           + LG    V++ G   ++EAL+   + F  R      + +FK  G+  S+G+  K+  RF
Sbjct: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140

Query: 131 AIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDR 190
            +  LR+FG+GK+ +EERIQEE+  L EAI+  +G   DP F ++  VSN+I SI FG+R
Sbjct: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200

Query: 191 FDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAK 250
           F+Y+D  F  LL ++  +    ++ T QLY +F  +MK LPGP Q  F   + L+ F++ 
Sbjct: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260

Query: 251 KVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTL 310
            ++ +++  +P   +DFID++L  M +   NP + F+ +NL+ STL+LF AGTET STTL
Sbjct: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320

Query: 311 RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSL 370
           R+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPY  AVIHE+QR G++IP+++
Sbjct: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380

Query: 371 ARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFV 430
            R V  DT    + LPKGT +   L ++ RDP+ ++ P  FNP HFL++ GQFKK +AF+
Sbjct: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN-GQFKKREAFM 439

Query: 431 PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPK 469
           PFSIGKR C GE LAR ELF+FFT++MQ F  +   + K
Sbjct: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEK 478


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  311 bits (797), Expect = 9e-85
 Identities = 192/509 (37%), Positives = 281/509 (55%), Gaps = 30/509 (5%)

Query: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNY----------------LQLNTEH 53
           ALL C  V +L   W +R+    +PPGPTP P +GN+                 +     
Sbjct: 36  ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95

Query: 54  ICDSIM-------KFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQAT 106
           I  S++         +  YG +F+  +G   VVVL    +VREALV QAE FS R     
Sbjct: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155

Query: 107 FDWVFKGYGVAFSN-GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHG 165
              V K  GV F++ G   +Q  +F+ +TLR FG+GK  +E +I EE  + ++A    HG
Sbjct: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKY-VKAEMQKHG 214

Query: 166 AN-IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFS 224
            +   P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +  
Sbjct: 215 EDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-C 273

Query: 225 SVMKHLP-GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKN-P 282
             + +LP GP ++  ++ + +  F+ K ++ +Q +LD  +PQDFID +L+HM+EE KN  
Sbjct: 274 PWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNS 333

Query: 283 NTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPK 342
           N+ F  + L     +LFIAGT+T + +L +  L +  +P+V+ KVHEEI+RVIG NR P 
Sbjct: 334 NSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPS 393

Query: 343 FEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDP 402
             D+ +MPY EA I E+QR   V+P+++     ++T  + + +PKGT + P L SV RDP
Sbjct: 394 LTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDP 453

Query: 403 SFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 462
           + +  P+DF P  FLDD+GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ+F  
Sbjct: 454 AIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAF 513

Query: 463 K-SSQSPKDIDVSPKHVVFATIPRNYTMS 490
                S K +      +  A  P N T+S
Sbjct: 514 ALPEDSKKPLLTGRFGLTLAPHPFNITIS 542


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  302 bits (773), Expect = 5e-82
 Identities = 180/498 (36%), Positives = 281/498 (56%), Gaps = 17/498 (3%)

Query: 8   LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECY 65
           LV L   + + +L+     R+ R   + PPGP PLP +GN L ++ ++      +    +
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGE---QATFDWVFKGYGVAFSN-G 121
           G VF++ L    VVVL G  AVREALV   E+ + R          +  +  GV  +  G
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125

Query: 122 ERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNV 181
              ++  RF+++TLR+ G+GK+ +E+ + EE+  L  A  +  G    P   L + VSNV
Sbjct: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185

Query: 182 ISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSS--VMKHLPGPQQQAFK 239
           I+S+  G RF+Y+D  FL LL +     +     +G L E+ ++  V+ H+P    +  +
Sbjct: 186 IASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLR 242

Query: 240 LLQGLEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNL 298
             +     + + +  ++ T DP   P+D  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302

Query: 299 FIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHE 358
           F AG  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+  MPY  AVIHE
Sbjct: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362

Query: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLD 418
           +QRFGD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFLD
Sbjct: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422

Query: 419 DKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV 478
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F   S   P        H 
Sbjct: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---SFSVPTGQPRPSHHG 479

Query: 479 VFATI--PRNYTMSFLPR 494
           VFA +  P  Y +  +PR
Sbjct: 480 VFAFLVTPSPYELCAVPR 497


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  297 bits (761), Expect = 1e-80
 Identities = 165/456 (36%), Positives = 258/456 (56%), Gaps = 4/456 (0%)

Query: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIM--KFSECYGP 67
           AL   L  + +  + +QR+  G  PPGP  LPFIGN   L        +   K S+ YG 
Sbjct: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75

Query: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN-GERAKQ 126
           +F++ LG    VVL G+D V+E LV Q+E F+ R     F  + K  G+  S  G     
Sbjct: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135

Query: 127 LLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIV 186
             R A+ + R FG G++  E +I EE+ F  +AI +  G   D    ++  VSN+ + I+
Sbjct: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195

Query: 187 FGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLED 246
           FG+RF YED +F  ++ +     +  ++++  LY  F  +     G  QQ F+    + D
Sbjct: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255

Query: 247 FIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETV 306
           F+++ +E       P  PQ F+D++L  M + + +P++ F  +NL+ S   L IAGTET 
Sbjct: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315

Query: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVI 366
           +  LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPY EAV+HE+ RF +++
Sbjct: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375

Query: 367 PMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKS 426
           P+ +     +D   R + +PKGT V   L SV  D  ++ +P+ F+P+ FLD  G F K 
Sbjct: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435

Query: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 462
           +A VPFS+G+R+C GE LARME+FLFFT ++Q F L
Sbjct: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  297 bits (760), Expect = 2e-80
 Identities = 179/497 (36%), Positives = 269/497 (54%), Gaps = 18/497 (3%)

Query: 6   LLLVALLACLTVMVLMSVWQQRKS-RGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSEC 64
           LLL+  L  L +  L+    Q  S   + PPGP PLP +GN   L       S+M+ SE 
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 65  YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERA 124
           YGPVFT+HLG ++ VVL G +AV+EAL    +E + R   A F  + +G G+ FS+G R 
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 125 KQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISS 184
           +   +F +  L   GVG+  + ++I +E   L   +    G    P   L    SN+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 185 IVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMF----SSVMKHLPGPQQQAFKL 240
           ++FG RFDY D  F+SLL ++  +     +   QL+ ++    + +  H P       + 
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRP-----VLRK 236

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPQ-DFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLF 299
           ++ +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N +  TL++ 
Sbjct: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMV 294

Query: 300 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEI 359
           +AGTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PY  AV+HE+
Sbjct: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354

Query: 360 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDD 419
           QRF  ++P  + R    DT+   F LPKGT V P+L SVL D + +  P  FNP HFLD 
Sbjct: 355 QRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413

Query: 420 KGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL--KSSQSPKDIDVSPKH 477
            G F K +AF+PFS G+R C GE LAR ELFL F  ++Q +RL      SP  +D +P  
Sbjct: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR 473

Query: 478 VVFATIPRNYTMSFLPR 494
             F   PR   +  +PR
Sbjct: 474 -AFTMRPRAQALCAVPR 489


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  263 bits (672), Expect = 3e-70
 Identities = 167/494 (33%), Positives = 255/494 (51%), Gaps = 60/494 (12%)

Query: 8   LVALLACLTVMVLMSVWQQRKSR--GKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECY 65
           LV L   + + +L+     R+ R   + PPGP PLP +GN L ++ ++      +    +
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAK 125
           G VF++ L    VVVL G  AVREALV   E+ + R                        
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP---------------------- 103

Query: 126 QLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSI 185
                 +   +  G G R                   + G    P   L + VSNVI+S+
Sbjct: 104 ------VPITQILGFGPR-------------------SQGRPFRPNGLLDKAVSNVIASL 138

Query: 186 VFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSV--MKHLPGPQQQAFKLLQG 243
             G RF+Y+D  FL LL +     +     +G L E+ ++V  + H+P    +  +  + 
Sbjct: 139 TCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKA 195

Query: 244 LEDFIAKKVEHNQRTLDP-NSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAG 302
               + + +  ++ T DP   P+D  ++FL  M++ + NP + F  +NL +   +LF AG
Sbjct: 196 FLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAG 255

Query: 303 TETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRF 362
             T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+  MPY  AVIHE+QRF
Sbjct: 256 MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF 315

Query: 363 GDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQ 422
           GD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFLD +G 
Sbjct: 316 GDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH 375

Query: 423 FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFAT 482
           F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F   S   P        H VFA 
Sbjct: 376 FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF---SFSVPTGQPRPSHHGVFAF 432

Query: 483 I--PRNYTMSFLPR 494
           +  P  Y +  +PR
Sbjct: 433 LVTPSPYELCAVPR 446


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  243 bits (621), Expect = 2e-64
 Identities = 154/492 (31%), Positives = 256/492 (52%), Gaps = 23/492 (4%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTE-HICDSIM 59
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L    H+  ++ 
Sbjct: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHL--ALS 64

Query: 60  KFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFS 119
           + S+ YG V  I +G   VVVL G D +R+ALV Q ++F GR +  TF  +  G  ++FS
Sbjct: 65  RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124

Query: 120 --NGERAKQLLRFAIATLRDFGVGKRG-------IEERIQEESGFLIEAIRSTHGA--NI 168
             +G       R A   L+ F +           +EE + +E+  LI  ++       + 
Sbjct: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184

Query: 169 DPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMK 228
           +P  ++  +V+NVI +I FG R+D+  +E LSL+++     +   +        F  +++
Sbjct: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILR 241

Query: 229 HLPGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEE--KNPNTE 285
           +LP P   AFK L +    F+ K V+ + +T +    +D  DS + H QE++  +N N +
Sbjct: 242 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 301

Query: 286 FYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFED 345
              + ++   L+LF AG +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  D
Sbjct: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361

Query: 346 RTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFF 405
           R+ +PYMEA I E  R    +P ++     +DT  + F++PKG  VF     +  D   +
Sbjct: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421

Query: 406 SNPQDFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463
            NP +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q     
Sbjct: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481

Query: 464 SSQSPKDIDVSP 475
                K +D++P
Sbjct: 482 VPLGVK-VDMTP 492


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  207 bits (527), Expect = 2e-53
 Identities = 141/489 (28%), Positives = 235/489 (48%), Gaps = 22/489 (4%)

Query: 3   ASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTE-HICDSIMKF 61
           A+ LLL + + CL   VL  +  +     K PP P   P +G+ L L    H+  ++ + 
Sbjct: 11  ATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHL--ALSRM 68

Query: 62  SECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFS-- 119
           S+ YG V  I +G   V+VL   D +R+ALV Q ++F GR +  T   +  G  + FS  
Sbjct: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128

Query: 120 NGERAKQLLRFAIATLRDFGVGKRG-------IEERIQEESGFLIEAIRSTHGA--NIDP 170
           +G       R A   L  F +           +EE + +E+  LI  ++       + DP
Sbjct: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188

Query: 171 TFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHL 230
              +  +V+NVI ++ FG  F     E LSL+       +F  T++      F  ++++L
Sbjct: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK---NTHEFVETASSGNPLDFFPILRYL 245

Query: 231 PGPQQQAFKLL-QGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLK 289
           P P  Q FK   Q    F+ K V+ + +  D NS +D   +   H ++  +        +
Sbjct: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305

Query: 290 NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKM 349
            ++    ++F AG +TV+T + +  + L+  PE++ K+ +E+D VIG+ R+P+  DR ++
Sbjct: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365

Query: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQ 409
           PY+EA I E  R    +P ++     +DT    F++PK   VF     V  DP  + +P 
Sbjct: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425

Query: 410 DFNPQHFLDDKG---QFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 466
           +F P+ FL   G       S+  + F +GKR C GE LA+ E+FLF   ++Q        
Sbjct: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485

Query: 467 SPKDIDVSP 475
             K +D++P
Sbjct: 486 GVK-VDLTP 493


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  207 bits (526), Expect = 2e-53
 Identities = 147/485 (30%), Positives = 253/485 (52%), Gaps = 27/485 (5%)

Query: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLN-TEHICDSIMKFSEC 64
           LLL+++LA + V   + + Q+R+     PPGP   P IGN   +    H+  S  + +  
Sbjct: 24  LLLLSVLATVHVGQRL-LRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHL--SFARLARR 80

Query: 65  YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN-GER 123
           YG VF I LG   +VVL G  A+ +ALV Q   F+ R   A+F  V  G  +AF +  E 
Sbjct: 81  YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140

Query: 124 AKQLLRFAIATLRDFGV----GKRGIEERIQEESGFLIEAI--RSTHGANIDPTFFLSRT 177
            K   R A + +R+F       ++ +E  +  E+  L+  +   S  GA +DP       
Sbjct: 141 WKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVA 200

Query: 178 VSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQA 237
           V+NV+S++ FG R+ ++D EF  LLS      +  +   G L ++    +++ P P +  
Sbjct: 201 VANVMSAVCFGCRYSHDDPEFRELLSHNEEFGR--TVGAGSLVDVMPW-LQYFPNPVRTV 257

Query: 238 FK----LLQGLEDFIAKKVEHNQRTLDPNS-PQDFIDSFLIHMQEEEKNPN----TEFYL 288
           F+    L +   +FI  K   +  +L P + P+D +D+F++  +++    +        L
Sbjct: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317

Query: 289 KNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTK 348
           +N+  +  ++F A  +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+  
Sbjct: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377

Query: 349 MPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNP 408
           +PY+ A ++E  RF   +P+++      +T    + +PK T VF    SV  DP  + NP
Sbjct: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437

Query: 409 QDFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ--NFRLKS 464
           ++F+P  FLD  G   K  +   + FS+GKR C GE L++M+LFLF + +    +FR   
Sbjct: 438 ENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANP 497

Query: 465 SQSPK 469
           ++  K
Sbjct: 498 NEPAK 502


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  185 bits (469), Expect = 9e-47
 Identities = 132/466 (28%), Positives = 237/466 (50%), Gaps = 16/466 (3%)

Query: 11  LLACLTVMVLMSVWQQRKSRG-KLPPGPTPLPFIGNYLQLNTE-HICDSIMKFSECYGPV 68
           L+A L + +    W +R+  G K P     LP +G+   L    H+ ++  K  + YGP+
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGY-GVAFSNGERAKQL 127
           +++ +G +  V++  H   +E L+ + ++FSGR + AT D       G+AF++     QL
Sbjct: 64  YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123

Query: 128 -LRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIV 186
             R A+AT   F  G + +E+ I +E   L + + + +G +ID +F +   V+NVIS I 
Sbjct: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183

Query: 187 FGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL-LQGLE 245
           F   +   D E   + +   GI    + S   L ++    +K  P    +  K  ++   
Sbjct: 184 FNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVKIRN 240

Query: 246 DFIAKKVEHNQRTLDPNSPQDFIDSFL-IHMQEEEKNP----NTEFYLKNLMMSTL-NLF 299
           D + K +E+ +     +S  + +D+ +   M  +  N     ++E    N +++T+ ++F
Sbjct: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300

Query: 300 IAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEI 359
            AG ET ++ +++    L+ +P+V+ K++EEID+ +G +R P   DR ++  +EA I E+
Sbjct: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360

Query: 360 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDD 419
            R   V PM +  +   D+   +F + KGTEV   L ++  +   +  P  F P+ FL+ 
Sbjct: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 420 KGQ--FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463
            G      S +++PF  G R+C GE LAR ELFL    ++Q F L+
Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  149 bits (376), Expect = 6e-36
 Identities = 122/478 (25%), Positives = 228/478 (47%), Gaps = 36/478 (7%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           ML  GLLL  LL  L    L+  W + +S    P  P        +L L    +   ++ 
Sbjct: 1   MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51

Query: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
            ++ +GP++ +HLG + VVVL     + EA+V +  +F+GR E  T+  V + Y    S 
Sbjct: 52  LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSL 110

Query: 121 GERA------KQLLRFAIAT-LRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFF 173
           G+ +      K+L R A+   +RD       +E  +++ +    E +R+  G  +     
Sbjct: 111 GDYSLLWKAHKKLTRSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEE 164

Query: 174 LSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGP 233
            S    ++I  + FGD+   +D    +    +  + +  S  + Q+ ++    ++  P P
Sbjct: 165 FSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNP 222

Query: 234 QQQAFK-LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLK-NL 291
             +  K  ++  +  +  ++  ++ +L     +D +D  L  + +      +   L+ ++
Sbjct: 223 GLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHV 282

Query: 292 MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRT 347
            M+ ++L I GTET + TL +  + L+ HPE++ ++ EE+D  +G     +R P ++DR 
Sbjct: 283 HMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRA 341

Query: 348 KMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSN 407
           ++P + A I E+ R   V+P++L  R  + +    + +P+GT + P L     D + +  
Sbjct: 342 RLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWER 401

Query: 408 PQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
           P +F P  FL+      K+   + F  G R C GE LAR+ELF+  T ++Q F L  S
Sbjct: 402 PHEFWPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  121 bits (304), Expect = 1e-27
 Identities = 110/472 (23%), Positives = 215/472 (45%), Gaps = 54/472 (11%)

Query: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
           ML  GLLL  LL  L    L+  W + +S    P  P        +L L    +   ++ 
Sbjct: 1   MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51

Query: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
            ++ +GP++ +HLG            +++ LV +       G+   +  ++K +      
Sbjct: 52  LTQKFGPIYRLHLG------------LQDKLVSRNYPDLSLGD---YSLLWKAH------ 90

Query: 121 GERAKQLLRFAIAT-LRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVS 179
               K+L R A+   +RD       +E  +++ +    E +R+  G  +      S    
Sbjct: 91  ----KKLTRSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 140

Query: 180 NVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFK 239
           ++I  + FGD+   +D    +    +  + +  S  + Q+ ++    ++  P P  +  K
Sbjct: 141 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLK 198

Query: 240 -LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLK-NLMMSTLN 297
             ++  +  +  ++  ++ +L     +D +D  L  + +      +   L+ ++ M+ ++
Sbjct: 199 QAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVD 258

Query: 298 LFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRTKMPYME 353
           L I GTET + TL +  + L+ HPE++ ++ EE+D  +G     +R P ++DR ++P + 
Sbjct: 259 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLN 317

Query: 354 AVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNP 413
           A I E+ R   V+P++L  R  + +    + +P+GT + P L     D + +  P +F P
Sbjct: 318 ATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWP 377

Query: 414 QHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
             FL+      K+   + F  G R C GE LAR+ELF+  T ++Q F L  S
Sbjct: 378 DRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 425


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  119 bits (298), Expect = 6e-27
 Identities = 117/455 (25%), Positives = 193/455 (42%), Gaps = 53/455 (11%)

Query: 35  PGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 94
           PGPTPLPF+GN L  + +  C   M+  + YG V+  + G + V+ +   D ++  LV +
Sbjct: 39  PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97

Query: 95  AEEFSGRGEQATFDWV-FKGYGVAFSNGERAKQL------------LRFAIATLRDFG-V 140
              +S    +  F  V F    ++ +  E  K+L            L+  +  +  +G V
Sbjct: 98  C--YSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155

Query: 141 GKRGIEERIQEESG-----------FLIEAIRSTH-GANIDPTFFLSRTVSNVISSIVFG 188
             R +  R + E+G           + ++ I ST  G NID    L+      + +    
Sbjct: 156 LVRNL--RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS---LNNPQDPFVENTKKL 210

Query: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248
            RFD+ D  FLS+      +F F              V+     P++    L + ++   
Sbjct: 211 LRFDFLDPFFLSIT-----VFPFLIP--------ILEVLNICVFPREVTNFLRKSVKRMK 257

Query: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308
             ++E  Q+        DF+   +     +E   +       L+  ++    AG ET S+
Sbjct: 258 ESRLEDTQK-----HRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSS 312

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368
            L +    L  HP+V+ K+ EEID V+     P ++   +M Y++ V++E  R    I M
Sbjct: 313 VLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAM 371

Query: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428
            L R  KKD +    F+PKG  V     ++ RDP +++ P+ F P+ F            
Sbjct: 372 RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463
           + PF  G RNC G   A M + L    V+QNF  K
Sbjct: 432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  113 bits (282), Expect = 5e-25
 Identities = 119/501 (23%), Positives = 218/501 (43%), Gaps = 56/501 (11%)

Query: 2   LASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTE--HICDSIM 59
           LA   L+++LL    V      WQQ +    +P      P +G+ L +  +       I+
Sbjct: 24  LAGASLVLSLLQ--RVASYARKWQQMRP---IPTVARAYPLVGHALLMKPDGREFFQQII 78

Query: 60  KFSECYG--PVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVA 117
           +++E Y   P+  + +GP  +V L   + V   L    +       +    W+  G   +
Sbjct: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTS 138

Query: 118 FSNGERAKQLL---RFAIATLRDFGVGKRGIEERIQEESGFLIEAI-RSTHGANIDPTFF 173
             N  R+++ +    F    L DF        + + E++  L++ + +  +    +  F+
Sbjct: 139 TGNKWRSRRKMLTPTFHFTILEDF-------LDIMNEQANILVKKLEKHINQEAFNCFFY 191

Query: 174 LSRTVSNVISSIVFGDRF---DYEDKEFL-SLLSMMLGIFQFTSTSTGQL---YEMFSSV 226
           ++    ++I     G        +D E++ ++  M   IF+        L   Y MF   
Sbjct: 192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG 251

Query: 227 MKHLPGPQQQAFKLLQGLEDF----IAKKVEHNQRTLD-----------PNSPQDFIDSF 271
            +H         K LQ L  F    IA++        D            N  + F+D  
Sbjct: 252 WEHK--------KSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLD-L 302

Query: 272 LIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEI 331
           L+ + ++E N  +    +++          G +T +  + +   LL  +PEV+ KV  E+
Sbjct: 303 LLSVTDDEGNRLSH---EDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHEL 359

Query: 332 DRVIGKNRQPK-FEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTE 390
           D V GK+ +P   ED  K+ Y+E VI E  R    +P+  AR V +D +   + + KGTE
Sbjct: 360 DDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTE 418

Query: 391 VFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELF 450
              +  ++ RDP +F NP++F P+ F  +  Q +   A+VPFS G RNC G+  A ME  
Sbjct: 419 AVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEK 478

Query: 451 LFFTTVMQNFRLKSSQSPKDI 471
              + ++++F ++S+Q  +++
Sbjct: 479 TILSCILRHFWIESNQKREEL 499


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  112 bits (281), Expect = 6e-25
 Identities = 121/480 (25%), Positives = 206/480 (42%), Gaps = 42/480 (8%)

Query: 35  PGPTPLPFIGNYLQLNTEHICDSIMKF-SECY---GPVFTIHLGPRRVVVLCGHDAVREA 90
           PGPTPLP +GN L          + KF +ECY   G ++  + G   V+ +   D +R  
Sbjct: 39  PGPTPLPLLGNVLSYR-----QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTV 93

Query: 91  LVDQAEE-FSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGK-RGIEER 148
           LV +    F+ R         F    ++ +  E  K++      T   F  GK + +   
Sbjct: 94  LVKECYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPI 148

Query: 149 IQEESGFLIEAIR--STHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMML 206
           I +    L+  +R  +  G  +           +VI+   FG   D  +      +    
Sbjct: 149 IAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTK 208

Query: 207 GIFQFTSTSTGQLYEMFSSVMKH-LPGPQQQAFKLLQGLED---FIAKKVEHNQRTLDPN 262
              +F     G L  +F S++      P  +A  +    +D   F++K V   +++   +
Sbjct: 209 KFLKF-----GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 263

Query: 263 SPQDFIDSFLIHMQEEEKNPNTEFY--LKNLMMSTLNLFI--AGTETVSTTLRYGFLLLM 318
             +  +D FL  M + + +  TE +  L +L ++  ++    AG ET S+ L +    L 
Sbjct: 264 KQKHRLD-FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 322

Query: 319 KHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDT 378
            HP+V+ K+ +EID V+     P ++   +M Y++ V++E  R   V  + L R  KKD 
Sbjct: 323 THPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV-AIRLERTCKKDV 381

Query: 379 KFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRN 438
           +    F+PKG+ V     ++  DP +++ P++F P+ F   K        + PF  G RN
Sbjct: 382 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY-IYTPFGTGPRN 440

Query: 439 CFGEGLARMELFLFFTTVMQNFRL---KSSQSPKDIDVS-----PKHVVFATIPRNYTMS 490
           C G   A M + L    V+QNF     K +Q P  +D        K +V     R+ T+S
Sbjct: 441 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLS 500


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  108 bits (271), Expect = 9e-24
 Identities = 102/461 (22%), Positives = 190/461 (41%), Gaps = 38/461 (8%)

Query: 35  PGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 94
           PGPTPLPF+G  L      + +   + +E YG ++ ++ G + ++V+   D ++  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 95  AEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESG 154
                   +       F    ++F+  E  K++            V  + +   I +   
Sbjct: 98  CYSVF-TNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTS--VKFKEMVPIISQCGD 154

Query: 155 FLIEAIR--STHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDK---------------E 197
            L+ ++R  + +  +I+   F      +VI+  +FG   D  +                +
Sbjct: 155 MLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLD 214

Query: 198 FLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQR 257
           FL    +++ +F F       L  +F ++   L  P+     L   +E     +++  Q+
Sbjct: 215 FLDPFLLLISLFPF-------LTPVFEALNIGL-FPKDVTHFLKNSIERMKESRLKDKQK 266

Query: 258 TLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLL 317
                   DF    +     +E   +       L+  ++ +  A  +T STTL +    L
Sbjct: 267 -----HRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYEL 321

Query: 318 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKD 377
             HP+V+ K+ EEID V+       ++   +M Y++ V++E  R   V+   + R  KKD
Sbjct: 322 ATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVV-SRVTRVCKKD 380

Query: 378 TKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKR 437
            +    F+PKG  V   + ++  DP +++ P+ F P+ F            ++PF  G R
Sbjct: 381 IEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPR 440

Query: 438 NCFGEGLARMELFLFFTTVMQNFRL---KSSQSPKDIDVSP 475
           NC G   A   + L     +QNF     K +Q P  +D  P
Sbjct: 441 NCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  105 bits (262), Expect = 9e-23
 Identities = 102/462 (22%), Positives = 191/462 (41%), Gaps = 39/462 (8%)

Query: 35  PGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 94
           PGPTPLPF+G  L      + +   + +E YG ++ ++ G + ++V+   D ++  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 95  AEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESG 154
                   +       F    ++F+  E  K++            V  + +   I +   
Sbjct: 98  CYSVF-TNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTS--VKFKEMVPIISQCGD 154

Query: 155 FLIEAIR--STHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDK---------------E 197
            L+ ++R  + +  +I+   F      +VI+  +FG   D  +                +
Sbjct: 155 MLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLD 214

Query: 198 FLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQR 257
           FL    +++ +F F       L  +F ++   L  P+     L   +E     +++  Q+
Sbjct: 215 FLDPFLLLISLFPF-------LTPVFEALNIGL-FPKDVTHFLKNSIERMKESRLKDKQK 266

Query: 258 TLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLL 317
                   DF    +     +E   +       L+  ++ +  A  +T STTL +    L
Sbjct: 267 -----HRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYEL 321

Query: 318 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKD 377
             HP+V+ K+ EEID V+       ++   +M Y++ V++E  R   V+   + R  KKD
Sbjct: 322 ATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVV-SRVTRVCKKD 380

Query: 378 TKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFK-KSDAFVPFSIGK 436
            +    F+PKG  V   + ++  DP +++ P+ F P+     K +       ++PF  G 
Sbjct: 381 IEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGP 440

Query: 437 RNCFGEGLARMELFLFFTTVMQNFRL---KSSQSPKDIDVSP 475
           RNC G   A   + L     +QNF     K +Q P  +D  P
Sbjct: 441 RNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,296,240
Number of Sequences: 37866
Number of extensions: 814236
Number of successful extensions: 2060
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1877
Number of HSP's gapped (non-prelim): 101
length of query: 494
length of database: 18,247,518
effective HSP length: 106
effective length of query: 388
effective length of database: 14,233,722
effective search space: 5522684136
effective search space used: 5522684136
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.