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Search of human proteins with 15147254
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
(925 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 1859 0.0
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 1815 0.0
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 1809 0.0
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 1802 0.0
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 1327 0.0
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 1325 0.0
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 1306 0.0
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 1296 0.0
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 1276 0.0
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 587 e-167
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 577 e-164
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens] 78 3e-14
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 69 2e-11
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 68 4e-11
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 68 4e-11
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 68 4e-11
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 65 4e-10
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 64 5e-10
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 63 1e-09
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 63 1e-09
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 62 2e-09
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 61 5e-09
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs... 60 7e-09
gi|108773804 Fraser syndrome 1 [Homo sapiens] 58 5e-08
gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens] 43 0.002
gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens] 43 0.002
gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens] 43 0.002
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens] 41 0.005
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 35 0.42
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 34 0.55
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 1859 bits (4816), Expect = 0.0
Identities = 925/925 (100%), Positives = 925/925 (100%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
Query: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPDRKLTMEEEEAKRIAEMGKPVLGE 660
KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPDRKLTMEEEEAKRIAEMGKPVLGE
Sbjct: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPDRKLTMEEEEAKRIAEMGKPVLGE 660
Query: 661 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 720
HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE
Sbjct: 661 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 720
Query: 721 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 780
RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT
Sbjct: 721 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 780
Query: 781 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 840
IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV
Sbjct: 781 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 840
Query: 841 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 900
AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT
Sbjct: 841 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 900
Query: 901 WLFVSLWLLYILFATLEAYCYIKGF 925
WLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 901 WLFVSLWLLYILFATLEAYCYIKGF 925
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 1815 bits (4700), Expect = 0.0
Identities = 902/925 (97%), Positives = 913/925 (98%), Gaps = 1/925 (0%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTI +
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
Query: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPDRKLTMEEEEAKRIAEMGKPVLGE 660
K++D+E YE+ +N+FI + P+ ++ ALLLSPDRKLTMEEEEAKRIAEMGKPVLGE
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGI-SALLLSPDRKLTMEEEEAKRIAEMGKPVLGE 659
Query: 661 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 720
HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE
Sbjct: 660 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 719
Query: 721 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 780
RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT
Sbjct: 720 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 779
Query: 781 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 840
IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV
Sbjct: 780 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 839
Query: 841 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 900
AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT
Sbjct: 840 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 899
Query: 901 WLFVSLWLLYILFATLEAYCYIKGF 925
WLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 900 WLFVSLWLLYILFATLEAYCYIKGF 924
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 1809 bits (4686), Expect = 0.0
Identities = 902/928 (97%), Positives = 913/928 (98%), Gaps = 4/928 (0%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTI +
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
Query: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSP---DRKLTMEEEEAKRIAEMGKPV 657
K++D+E YE+ +N+FI + P+ ++ ALLLSP DRKLTMEEEEAKRIAEMGKPV
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGI-SALLLSPDVTDRKLTMEEEEAKRIAEMGKPV 659
Query: 658 LGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDES 717
LGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDES
Sbjct: 660 LGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDES 719
Query: 718 GEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHF 777
GEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHF
Sbjct: 720 GEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHF 779
Query: 778 GCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLA 837
GCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLA
Sbjct: 780 GCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLA 839
Query: 838 WSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKL 897
WSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKL
Sbjct: 840 WSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKL 899
Query: 898 ATTWLFVSLWLLYILFATLEAYCYIKGF 925
ATTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 900 ATTWLFVSLWLLYILFATLEAYCYIKGF 927
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 1802 bits (4668), Expect = 0.0
Identities = 896/925 (96%), Positives = 907/925 (98%), Gaps = 4/925 (0%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL
Sbjct: 1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVIL 60
Query: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE
Sbjct: 61 PIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGE 120
Query: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI
Sbjct: 121 TSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
Query: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF
Sbjct: 181 IIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Query: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN
Sbjct: 241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGN 300
Query: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR
Sbjct: 301 LVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATR 360
Query: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR
Sbjct: 361 MMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVR 420
Query: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF
Sbjct: 421 KGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF 480
Query: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH
Sbjct: 481 FVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIH 540
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTI +
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRV 600
Query: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPDRKLTMEEEEAKRIAEMGKPVLGE 660
K++D+E YE+ +N+FI + P+ ++ DRKLTMEEEEAKRIAEMGKPVLGE
Sbjct: 601 KIVDEEEYERQENFFIALGEPKWMERGISDV----TDRKLTMEEEEAKRIAEMGKPVLGE 656
Query: 661 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 720
HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE
Sbjct: 657 HPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEE 716
Query: 721 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 780
RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT
Sbjct: 717 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCT 776
Query: 781 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 840
IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV
Sbjct: 777 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSV 836
Query: 841 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 900
AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT
Sbjct: 837 AAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATT 896
Query: 901 WLFVSLWLLYILFATLEAYCYIKGF 925
WLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 897 WLFVSLWLLYILFATLEAYCYIKGF 921
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 1327 bits (3434), Expect = 0.0
Identities = 680/973 (69%), Positives = 790/973 (81%), Gaps = 56/973 (5%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLS------------ 635
EF+NDE VKTI +KVIDDE YEKNK +F+E+ PR+V+MS +KALLL+
Sbjct: 596 EFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGQPV 655
Query: 636 -----------------------PDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESY 672
+ LT +EEE +RIAEMG+P+LGEH KLEVIIEESY
Sbjct: 656 FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY 715
Query: 673 EFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHF 732
EFK+TVDKLIKKTNLALVVGT+SWR+QF+EAITVSA D+D+DE GEE+LPSCFDYVMHF
Sbjct: 716 EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF 775
Query: 733 LTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVF 792
LTVFWKVLFA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSVTAVVF
Sbjct: 776 LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF 835
Query: 793 VAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEF 852
VA GTSVPDTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A G++F
Sbjct: 836 VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF 895
Query: 853 HVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYIL 912
VS GTLAFSVTLFTIFAF+ + VLLYRRRP +GGELGGPR KL T+ LFV LWLLYI
Sbjct: 896 KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF 955
Query: 913 FATLEAYCYIKGF 925
F++LEAYC+IKGF
Sbjct: 956 FSSLEAYCHIKGF 968
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 1325 bits (3429), Expect = 0.0
Identities = 680/978 (69%), Positives = 790/978 (80%), Gaps = 61/978 (6%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLS------------ 635
EF+NDE VKTI +KVIDDE YEKNK +F+E+ PR+V+MS +KALLL+
Sbjct: 596 EFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYL 655
Query: 636 ----------------------------PDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVI 667
+ LT +EEE +RIAEMG+P+LGEH KLEVI
Sbjct: 656 FGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVI 715
Query: 668 IEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFD 727
IEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EAITVSA D+D+DE GEE+LPSCFD
Sbjct: 716 IEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFD 775
Query: 728 YVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSV 787
YVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSV
Sbjct: 776 YVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSV 835
Query: 788 TAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWAL 847
TAVVFVA GTSVPDTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A
Sbjct: 836 TAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAA 895
Query: 848 QGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLW 907
G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP +GGELGGPR KL T+ LFV LW
Sbjct: 896 NGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLW 955
Query: 908 LLYILFATLEAYCYIKGF 925
LLYI F++LEAYC+IKGF
Sbjct: 956 LLYIFFSSLEAYCHIKGF 973
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 1306 bits (3380), Expect = 0.0
Identities = 663/942 (70%), Positives = 777/942 (82%), Gaps = 25/942 (2%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVST---LACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSPD----RKLTME 643
EF+NDE VK I I++ D E YEK ++ + + P+ + + ++ + + LT +
Sbjct: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDDKQPLTSK 655
Query: 644 EEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEA 703
EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDKLIKKTNLALVVGT+SWR+QF+EA
Sbjct: 656 EEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEA 715
Query: 704 ITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILII 763
ITVSA D+D+DE GEE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+I
Sbjct: 716 ITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMI 775
Query: 764 GMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVT 823
G+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVPDTFASK AA QD YADASIGNVT
Sbjct: 776 GLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVT 835
Query: 824 GSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRP 883
GSNAVNVFLGIG+AWS+AAIY A G++F VS GTLAFSVTLFTIFAF+ + VLLYRRRP
Sbjct: 836 GSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRP 895
Query: 884 HLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 925
+GGELGGPR KL T+ LFV LWLLYI F++LEAYC+IKGF
Sbjct: 896 EIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 1296 bits (3354), Expect = 0.0
Identities = 663/965 (68%), Positives = 776/965 (80%), Gaps = 48/965 (4%)
Query: 1 MAWLRLQPLTSAFLHFGLVTFVLF--LNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGV 58
M L L P S H + +LF ++ + AE G+ TG+ C+GS CK+GV
Sbjct: 4 MRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGE----CTGSYYCKKGV 59
Query: 59 ILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPN 118
ILPIW P++PS GDKIAR VYFVA++YMFLGVSIIADRFM+SIEVITSQE+E+TIKKPN
Sbjct: 60 ILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPN 119
Query: 119 GETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNM 178
GET+ TT+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AGDLGPSTIVGSAAFNM
Sbjct: 120 GETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNM 179
Query: 179 FIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTL 238
FIII +CVYV+PDGETRKIKHLRVFF+TAAWSIFAY WLY+IL+V SPGVV+VWEGLLT
Sbjct: 180 FIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTF 239
Query: 239 FFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG---IEMDGKMMNSH 295
FFFP+CV+ AWVAD+RLLFYKY++K+YR K RG+IIE EGD P IEMDGK++NSH
Sbjct: 240 FFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSH 299
Query: 296 ---FLDGNLVPLEGKEVD----ESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQ 348
FLDG LV LE E D E+RREM RILK+LKQKHP+K+++QL+E+ANY LS QQ
Sbjct: 300 VENFLDGALV-LEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQ 358
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-DFISKVFFDPCSYQC 407
KSRAFYRIQATR+MTGAGNILK+HAA+QA+KA SM EV+T+ E D +SK+FF+ +YQC
Sbjct: 359 KSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQC 418
Query: 408 LENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVG 467
LENCG V LT++R+GGD++ T++VD++TEDG+ANAG+DYEFTEGTVV KPG+TQKE VG
Sbjct: 419 LENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVG 478
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDD 527
IIDDDIFEEDE+F V LSNV++ E E+G+ A S A L SP ATVTI DDD
Sbjct: 479 IIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS---TLACLGSPSTATVTIFDDD 535
Query: 528 HAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGEL 587
HAGIFTFE HVSESIG+MEVKVLRTSGARG VIVP++T+EGTA+GGGEDFEDT GEL
Sbjct: 536 HAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGEL 595
Query: 588 EFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLS------------ 635
EF+NDE VK I I++ D E YEK ++ + + P+ + + ++
Sbjct: 596 EFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITGQPVFRKVHARE 655
Query: 636 ---------------PDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDK 680
+ LT +EEE +RIAEMG+P+LGEH KLEVIIEESYEFK+TVDK
Sbjct: 656 HPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDK 715
Query: 681 LIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVL 740
LIKKTNLALVVGT+SWR+QF+EAITVSA D+D+DE GEE+LPSCFDYVMHFLTVFWKVL
Sbjct: 716 LIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVL 775
Query: 741 FACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVP 800
FA VPPTEY +GWACF VSIL+IG+LTA IGDLASHFGCTIGLKDSVTAVVFVA GTSVP
Sbjct: 776 FAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVP 835
Query: 801 DTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLA 860
DTFASK AA QD YADASIGNVTGSNAVNVFLGIG+AWS+AAIY A G++F VS GTLA
Sbjct: 836 DTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLA 895
Query: 861 FSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYC 920
FSVTLFTIFAF+ + VLLYRRRP +GGELGGPR KL T+ LFV LWLLYI F++LEAYC
Sbjct: 896 FSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYC 955
Query: 921 YIKGF 925
+IKGF
Sbjct: 956 HIKGF 960
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 1276 bits (3303), Expect = 0.0
Identities = 630/892 (70%), Positives = 752/892 (84%), Gaps = 27/892 (3%)
Query: 48 CSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITS 107
C GS C+ GV+LP+W P++PSLGDK AR +VYFVA++YMFLGVSIIADRFMA+IEVITS
Sbjct: 43 CQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS 102
Query: 108 QEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGP 167
+E+E+TI K NGETS T+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AG+LGP
Sbjct: 103 KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGP 162
Query: 168 STIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPG 227
TIVGSAAFNMF++I +C+YVIP GE+RKIKHLRVFF+TA+WSIFAY+WLY+ILAVFSPG
Sbjct: 163 GTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPG 222
Query: 228 VVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEM 287
VVQVWE LLTL FFPVCV+ AW+ADKRLLFYKY++K+YRTD GIII EGD PK IE+
Sbjct: 223 VVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIEL 282
Query: 288 DGKMMNSHFLDGNL-----VPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342
DG + + G L P E +E+D SRRE+I+ILKDLKQKHP+KDL+QLV +ANYY
Sbjct: 283 DGTFVGAE-APGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYY 341
Query: 343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDP 402
AL HQQKSRAFYRIQATR+MTGAGN+L++HAA+ +++A+ DE +D S++FF+P
Sbjct: 342 ALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE-DDGASRIFFEP 400
Query: 403 CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQK 462
Y CLENCG+VLL+V +GG+ + T YVDY+TEDGSA AG+DYE++EGT+V KPGETQK
Sbjct: 401 SLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQK 460
Query: 463 EFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQ----PEEGMPPAIFNSLPLPRAVLASPCV 518
E +GIIDDDIFEEDEHFFVRL N+R+ + Q P+ G P+ L +P +
Sbjct: 461 ELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG---------GRPKGRLVAPLL 511
Query: 519 ATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGE 578
ATVTILDDDHAGIF+F+ +HVSE +G ++V+V+R+SGARGTV +P+RTV+GTA+GGG
Sbjct: 512 ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGV 571
Query: 579 DFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSP-- 636
+ED GELEF +DET+KT+ +K++DDE YEK N+FIE+ P+ + ALLL+
Sbjct: 572 HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGI-SALLLNQGD 630
Query: 637 -DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHS 695
DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHS
Sbjct: 631 GDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHS 690
Query: 696 WRDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW 753
WR+QF+EAITVS AGDE+E+E G EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW
Sbjct: 691 WREQFLEAITVS-AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW 749
Query: 754 ACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDV 813
ACF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD
Sbjct: 750 ACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQ 809
Query: 814 YADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVC 873
ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTLAFSVTLFT+FAFV
Sbjct: 810 CADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVG 869
Query: 874 ISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 925
I+VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 870 IAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 587 bits (1512), Expect = e-167
Identities = 289/289 (100%), Positives = 289/289 (100%)
Query: 637 DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW 696
DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW
Sbjct: 10 DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW 69
Query: 697 RDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACF 756
RDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACF
Sbjct: 70 RDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACF 129
Query: 757 AVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYAD 816
AVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYAD
Sbjct: 130 AVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYAD 189
Query: 817 ASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISV 876
ASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISV
Sbjct: 190 ASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISV 249
Query: 877 LLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 925
LLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 250 LLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 298
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 577 bits (1487), Expect = e-164
Identities = 284/284 (100%), Positives = 284/284 (100%)
Query: 642 MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM 701
MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM
Sbjct: 1 MEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFM 60
Query: 702 EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL 761
EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL
Sbjct: 61 EAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSIL 120
Query: 762 IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN 821
IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN
Sbjct: 121 IIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGN 180
Query: 822 VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR 881
VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR
Sbjct: 181 VTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRR 240
Query: 882 RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 925
RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
Sbjct: 241 RPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 284
>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
Length = 6306
Score = 78.2 bits (191), Expect = 3e-14
Identities = 68/273 (24%), Positives = 118/273 (43%), Gaps = 35/273 (12%)
Query: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCL 408
+ ++FY Q T + G ++ ++++ V +D P + F +
Sbjct: 4230 EEKSFYEFQLTAVSEGG-------VLSESSSTANITVVASDSP---YGRFAFSHEQLRVS 4279
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
E V +T++R GD + YKT G+A AG D+ G ++ + GE +K V I
Sbjct: 4280 E-AQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337
Query: 469 IDDDIFEEDEHFFVRLSNVR---------IEEEQPEEGMPPAIFNSLPLPRAVLASPCVA 519
+DDD E E F + ++ V I+E + PP I N +
Sbjct: 4338 LDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNI-----------SIV 4386
Query: 520 TVTILDDDHA-GIFTFE--CDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
+ I+ +D+A GI F+ V E +G++ + V+R G G V F + +A G
Sbjct: 4387 RIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPG 4446
Query: 577 GEDFEDTYGELEFKNDETVKTIHIKVIDDEAYE 609
G D+ + F++ + + I+I +IDD E
Sbjct: 4447 GVDYILHGSTVTFQHGQNLSFINISIIDDNESE 4479
Score = 68.2 bits (165), Expect = 3e-11
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 19/191 (9%)
Query: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
D A DY E +++K + V I+ DD+ E +E F V ++ V +
Sbjct: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFST 3886
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFE--------CDTIHVSESIGVM 548
G P S+ P +A + +DD GIF F V + V+
Sbjct: 3887 GQP-----SVRRPGMEIAEIMIEE----NDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937
Query: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAY 608
+V V+R +G+ G V V ++ +A G EDF+ ++G LEF + + I I +IDD +
Sbjct: 3938 QVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEF 3995
Query: 609 EKNKNYFIEMM 619
E + + I ++
Sbjct: 3996 ELTETFNISLI 4006
Score = 64.3 bits (155), Expect = 5e-10
Identities = 58/222 (26%), Positives = 92/222 (41%), Gaps = 28/222 (12%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTED------------GSANAGADYEFTEGTVVLKPGETQ 461
+ L+++R G M K + V Y T D A G DY G + +++
Sbjct: 1997 ITLSIIRLKGLMGKVL-VSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSE 2055
Query: 462 KEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATV 521
++ I+DDD E E F+ L N + A S +P + P V T+
Sbjct: 2056 ATIAISILDDDEPERSESVFIELLNSTLV----------AKVQSRSIPNSPRLGPKVETI 2105
Query: 522 T----ILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGG 577
I +DD G + V+E+ + V RT GA V V F+ V TA G
Sbjct: 2106 AQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAI-AG 2164
Query: 578 EDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMM 619
ED+ ++ ET K + I VI+D E +++ +++M
Sbjct: 2165 EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLM 2206
Score = 63.5 bits (153), Expect = 8e-10
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 24/194 (12%)
Query: 438 GSANAGADYE-FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
G A AG+DYE T +++ G+ +V I+ DD E DE F + L V +
Sbjct: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASL 2554
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTFECDTIHVSESIGVMEVK---- 551
P I P ++TV I L+ D G+F + + SE +EV+
Sbjct: 2555 KNQPTI-----------GQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQ 2603
Query: 552 ------VLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
+ RT G+ G V V +R V GTA G DF L F ET KT+ + ++DD
Sbjct: 2604 TLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTILDD 2662
Query: 606 EAYEKNKNYFIEMM 619
E +++ + ++
Sbjct: 2663 SEPEDDESIIVSLV 2676
Score = 62.0 bits (149), Expect = 2e-09
Identities = 58/210 (27%), Positives = 86/210 (40%), Gaps = 29/210 (13%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
+ L + R G + T V ED D+ T + GET + + + DDD+
Sbjct: 51 IRLIIERIGEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDL 105
Query: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIF 532
E DE F L+ + P L P TVTIL +D+A GI
Sbjct: 106 PEPDETFIFHLTLQK------------------PSANVKLGWPRTVTVTILSNDNAFGII 147
Query: 533 TFE-CDTIHVSESIG---VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELE 588
+F +I VSE G M + ++R G G V+V F VEG ED G +
Sbjct: 148 SFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNIT 206
Query: 589 FKNDETVKTIHIKVIDDEAYEKNKNYFIEM 618
F ++ V+DDE E ++ + I++
Sbjct: 207 FPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
Score = 59.7 bits (143), Expect = 1e-08
Identities = 65/243 (26%), Positives = 97/243 (39%), Gaps = 32/243 (13%)
Query: 399 FFDPCSYQCLENCGAVLLTVVRKGG--DMSKTMYVDYKTE-DGSANAGADYEFTEGTVVL 455
F C + E + V R G D Y + E DG D+ GT+
Sbjct: 1577 FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITF 1636
Query: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
P + + ++ ++DDDI E +E+F V L + P +G S P A +
Sbjct: 1637 LPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA-----IPGDGK----LGSTPTSGASIDP 1687
Query: 516 PCVAT-VTILDDDHA-GIFTFECDT-----------------IHVSESIGVMEVKVLRTS 556
T +TI DH G+ F I V E G + + V+R
Sbjct: 1688 EKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQ 1747
Query: 557 GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFI 616
G G V FRTV TA ED+++ G LEF+ E K I I + D+ E K++ +
Sbjct: 1748 GLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
Query: 617 EMM 619
E++
Sbjct: 1807 ELL 1809
Score = 59.3 bits (142), Expect = 2e-08
Identities = 61/239 (25%), Positives = 106/239 (44%), Gaps = 43/239 (17%)
Query: 414 VLLTVVRKGGDMSK-TMYVDYKTE-DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
V L V+R G +S T++ + ++ DG D FT G + + G+T +V I+ D
Sbjct: 1885 VTLNVIRHHGTLSPVTLHWNIDSDPDG------DLAFTSGNITFEIGQTSANITVEILPD 1938
Query: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAG 530
+ E D+ F V + +V G A N AT+T+L DD G
Sbjct: 1939 EDPELDKAFSVSVLSV-------SSGSLGAHIN--------------ATLTVLASDDPYG 1977
Query: 531 IFTFECDT--IHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG-----------G 577
IF F + V E+ + + ++R G G V+V + T++ K G
Sbjct: 1978 IFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQG 2037
Query: 578 EDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSP 636
D+ G F +++ TI I ++DD+ E++++ FIE++ +V +++ SP
Sbjct: 2038 RDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSP 2096
Score = 58.9 bits (141), Expect = 2e-08
Identities = 54/227 (23%), Positives = 88/227 (38%), Gaps = 31/227 (13%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEF 464
++ E G++ L R + Y ++ A G DY FT + GE K
Sbjct: 2969 FEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNV 3027
Query: 465 SVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL 524
++ I+DDDI E DE F + L+N P P L +A + +L
Sbjct: 3028 NIMILDDDIPEGDEKFQLILTN--------------------PSPGLELGKNTIALIIVL 3067
Query: 525 -DDDHAGIFTF---------ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
+DD G+ +F E ++V ES+ V+ + G GTV V F E +
Sbjct: 3068 ANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSS 3127
Query: 575 GGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
+D + G + + K + I I D E ++ + + P
Sbjct: 3128 NESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
Score = 58.5 bits (140), Expect = 3e-08
Identities = 56/225 (24%), Positives = 100/225 (44%), Gaps = 20/225 (8%)
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
E G + L V+R G + + +++T +A + DY+ GT+ +PGE K + I
Sbjct: 1734 EEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
Query: 469 IDDDIFEEDEHFFVRLSNV--------RIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
D+ I E ++ F V L N+ R++ +G F RA L
Sbjct: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDG-DMEFFLPTIHKRASLGVASQIL 1851
Query: 521 VTILDDDHA-GIFTFECDTIHVS-----ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
VTI DHA G+F F +++ VS + + + V+R G V + + ++
Sbjct: 1852 VTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPD 1910
Query: 575 GGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMM 619
G D T G + F+ +T I ++++ DE E +K + + ++
Sbjct: 1911 G---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSVL 1952
Score = 58.2 bits (139), Expect = 4e-08
Identities = 58/206 (28%), Positives = 93/206 (45%), Gaps = 26/206 (12%)
Query: 419 VRKGGDMSKTMYVDYKTEDGSANA-GADYEFTE--GTVVLKPGETQKEFSVGIIDDDIFE 475
V + G + T V Y T+DG A A D+ E T++ + G Q+ S+ + +D I E
Sbjct: 1024 VLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPE 1083
Query: 476 EDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTF 534
DE F++ L N + + G VATV I +DD GIF+
Sbjct: 1084 TDEPFYIILLNSTGDTVVYQYG--------------------VATVIIEANDDPNGIFSL 1123
Query: 535 ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG-TAKGGGEDFEDTYGELEFKNDE 593
E V E +LR G G+V V ++ + +A G++F +T G + F + E
Sbjct: 1124 EPIDKAVEEG-KTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGE 1182
Query: 594 TVKTIHIKVIDDEAYEKNKNYFIEMM 619
K I + D+ E N+ YF++++
Sbjct: 1183 EAKPIILHAFPDKIPEFNEFYFLKLV 1208
Score = 58.2 bits (139), Expect = 4e-08
Identities = 60/206 (29%), Positives = 90/206 (43%), Gaps = 27/206 (13%)
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
EN ++ V R GG + V +K +A AG DY VVL GET K + +
Sbjct: 2131 ENHVGPIINVTRTGGAFADVS-VKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYV 2189
Query: 469 IDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH 528
I+D E +E F V+L N E A + L AV+ + DD
Sbjct: 2190 INDIYPELEESFLVQLMN---------ETTGGARLGA--LTEAVI-------IIEASDDP 2231
Query: 529 AGIFTFECDTIHVSE----SIGVMEVKVLRTSGARGTVIVPF-RTVEGTAKGGGEDFEDT 583
G+F F+ + V E S+ V + ++R SG G V V + T+ G G D
Sbjct: 2232 YGLFGFQITKLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVV 2288
Query: 584 YGELEFKNDETVKTIHIKVIDDEAYE 609
G + F ET++T+ ++V+ D+ E
Sbjct: 2289 SGNVTFAPGETIQTLLLEVLADDVPE 2314
Score = 52.0 bits (123), Expect = 3e-06
Identities = 49/210 (23%), Positives = 91/210 (43%), Gaps = 15/210 (7%)
Query: 412 GAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
GA+ +T G +S + +T A D+ G ++L+ GET ++ I++D
Sbjct: 2856 GAINVTYTTVPGMLS----LKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILED 2911
Query: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGI 531
D+ E +E+F V L+ V G+ A S P PR + +D G+
Sbjct: 2912 DVPELEEYFLVNLTYV---------GLTMAASTSFP-PRLDSEGLTAQVIIDANDGARGV 2961
Query: 532 FTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKN 591
++ V+E+ G + + R+ G V + F + G D+ T L F +
Sbjct: 2962 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLEAQVGLDYIFTPMILHFAD 3020
Query: 592 DETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
E K ++I ++DD+ E ++ + + + P
Sbjct: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
Score = 50.8 bits (120), Expect = 6e-06
Identities = 44/171 (25%), Positives = 77/171 (45%), Gaps = 30/171 (17%)
Query: 444 ADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIF 503
+D+ + G ++ +PGE + +V I+DD + E++E F V+L N P+ G I
Sbjct: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKN-------PKGGAEIGIN 3637
Query: 504 NSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVS----ESIGVMEVKVLRTSGA 558
+S+ T+TIL +D A GI F ++++ E ++ + V R G
Sbjct: 3638 DSV-------------TITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGT 3684
Query: 559 RGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYE 609
G + T+ A G D T G + F + + TI + ++ D E
Sbjct: 3685 YGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPE 3730
Score = 50.4 bits (119), Expect = 7e-06
Identities = 50/202 (24%), Positives = 88/202 (43%), Gaps = 23/202 (11%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
V L + R GG + + V+++ G+A G D+ + GET+K + I+DD
Sbjct: 2606 VELMIHRTGGSLGQVA-VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
Query: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFT 533
E+DE V L E G R + +S V + +D+ AGI +
Sbjct: 2665 PEDDESIIVSL-------VYTEGG-----------SRILPSSDTVRVNILANDNVAGIVS 2706
Query: 534 FECDTIHVSESIG-VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
F+ + V G +++ V+RT RG V V ++ + + +F + G+L F
Sbjct: 2707 FQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEG 2763
Query: 593 ETVKTIHIKVIDDEAYEKNKNY 614
T+ + ++DD E+ + Y
Sbjct: 2764 SLNTTLFVHLLDDNIPEEKEVY 2785
Score = 49.3 bits (116), Expect = 2e-05
Identities = 58/250 (23%), Positives = 106/250 (42%), Gaps = 36/250 (14%)
Query: 404 SYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKE 463
+Y+ + + VVR G + V +K SA D++ + G + +
Sbjct: 3927 AYEVPPPLNVLQVPVVRLAGSFG-AVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAM 3984
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ IIDD FE E F + L +V L V TV I
Sbjct: 3985 IEITIIDDAEFELTETFNISLISVA--------------------GGGRLGDDVVVTVVI 4024
Query: 524 LDDDHA-GIFTFECDTIHVSESI------GVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
+D G+F FE T+ + ES+ + + V+R+ G +GTV + + T++ AK
Sbjct: 4025 PQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK-- 4081
Query: 577 GEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQK---ALL 633
+ G L F E+ KTI + + D E+++ + I+++ V++S K +++
Sbjct: 4082 -HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASII 4140
Query: 634 LSPDRKLTME 643
+ D++ + E
Sbjct: 4141 IRGDKRASGE 4150
Score = 47.0 bits (110), Expect = 8e-05
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 12/151 (7%)
Query: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE-GTVVLKPGETQKEFSVG 467
E+ + L V R G S + V Y+T GSA D+E + G + + +T+ +F +
Sbjct: 5018 EDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEIT 5077
Query: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILD-D 526
II+D + E +E F++ L++V I Q F+ PR L VA +TILD D
Sbjct: 5078 IINDQLSEIEEFFYINLTSVEIRGLQK--------FDVNWSPRLNL-DFSVAVITILDND 5128
Query: 527 DHAGI-FTFECDTIHVSESIGVMEVKVLRTS 556
D AG+ +F T+ V+ ++ V+ T+
Sbjct: 5129 DLAGMDISFPETTVAVAVDTTLIPVETESTT 5159
Score = 43.5 bits (101), Expect = 0.001
Identities = 57/253 (22%), Positives = 94/253 (37%), Gaps = 46/253 (18%)
Query: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVR----KGGDMSKTMY---VDYKTEDGSAN 441
D P F+ ++ P E +++ VVR G + Y + Y G++
Sbjct: 260 DSPVRFLQSIYLVP------EEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNST 313
Query: 442 AGADYEFT------EGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPE 495
A A TVV P + I+DD I E E F + L ++ +
Sbjct: 314 AHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD--- 370
Query: 496 EGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFEC----DTIHVSES--IGVM 548
AVL SP V VTI +D G+ +F T+ + E
Sbjct: 371 ---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYE 415
Query: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGG--GEDFEDTYGELEFKNDETVKTIHIKVIDDE 606
E+ V+R G G V + + D + G L F + + TI + V+DD+
Sbjct: 416 EITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDD 475
Query: 607 AYEKNKNYFIEMM 619
E+ + Y ++++
Sbjct: 476 LPEEAEAYLLQIL 488
Score = 42.0 bits (97), Expect = 0.003
Identities = 49/188 (26%), Positives = 79/188 (42%), Gaps = 34/188 (18%)
Query: 442 AGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNV----RIEEEQPEEG 497
A +D G + + GET K F + DD+ E +E F ++L +V RI EE
Sbjct: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
Query: 498 MPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTI-HVSESIGVMEVKVLRT 555
A +TI D+A G+F F I ++E + V RT
Sbjct: 1559 -------------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERT 1599
Query: 556 SGARGTVIVPFRTVEGTAKGG----GEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKN 611
GA V V F T+ G +DF + G + F + + ++I V+DD+ E N
Sbjct: 1600 RGALDYVHV-FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELN 1658
Query: 612 KNYFIEMM 619
+ + + ++
Sbjct: 1659 EYFRVTLV 1666
Score = 41.2 bits (95), Expect = 0.005
Identities = 52/214 (24%), Positives = 89/214 (41%), Gaps = 34/214 (15%)
Query: 413 AVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDD 472
+V L ++R G + K ++ Y+ E +N ++ G + KPGE + ++ D
Sbjct: 793 SVELHIIRSRGSLVK-QFLHYRVEPRDSN---EFYGNTGVLEFKPGEREIVITLLARLDG 848
Query: 473 IFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGI 531
I E DEH++V LS+ E + L S + +TIL +DD GI
Sbjct: 849 IPELDEHYWVVLSSHGERESK-------------------LGSATIVNITILKNDDPHGI 889
Query: 532 FTFECDTIHV------SESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYG 585
F D + V ++I V+R G G V V + + +D G
Sbjct: 890 IEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFGDVSVSW----VVSPDFTQDVFPVQG 945
Query: 586 ELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMM 619
+ F + E K I I + DE E+ + + + ++
Sbjct: 946 TVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILL 979
Score = 40.4 bits (93), Expect = 0.008
Identities = 55/234 (23%), Positives = 95/234 (40%), Gaps = 46/234 (19%)
Query: 390 EPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA--DYE 447
EPEDF ++V + P R G D T+Y K ++ A D
Sbjct: 664 EPEDFAAEVVYIPLH---------------RDGTDGQATVYWSLKPSGFNSKAVTPDDIG 708
Query: 448 FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLP 507
G+V+ G++ ++ I DDI E +E + L V +E + + G + S
Sbjct: 709 PFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSG-----YTSRD 763
Query: 508 LPRAVLASPCVATVTILDDDHAGIFTFECDT-----IHVSESIGVMEVKVLRTSGARGTV 562
L + + +DD G+F F + I ES+ E+ ++R +RG++
Sbjct: 764 L------------IILENDDPGGVFEFSPASRGPYVIKEGESV---ELHIIR---SRGSL 805
Query: 563 IVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFI 616
+ F + E + +T G LEFK E I + D E +++Y++
Sbjct: 806 VKQFLHYRVEPRDSNEFYGNT-GVLEFKPGEREIVITLLARLDGIPELDEHYWV 858
Score = 40.0 bits (92), Expect = 0.010
Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFE 475
LT++R+ G M V ++ E G D +G + PG +++ ++DD++ E
Sbjct: 169 LTLIREKGTYGMVM-VTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPE 227
Query: 476 EDEHFFVRLSNV 487
DE F ++L +V
Sbjct: 228 NDEIFLIQLKSV 239
Score = 38.1 bits (87), Expect = 0.038
Identities = 35/138 (25%), Positives = 58/138 (42%), Gaps = 27/138 (19%)
Query: 511 AVLASPCVATVTILDDDHAGIFTFECDTIHVSESI-----GVMEVKVLRTSGARGTVIV- 564
AV P VATVT H G F+ +++ E + EV + RT G G V +
Sbjct: 5200 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSIT 5258
Query: 565 ----------------PFRTVEG----TAKGGGEDFEDTYGELEFKNDETVKTIHIKVID 604
PFR + G T EDFE+ L F + E + + ++++D
Sbjct: 5259 VKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILD 5318
Query: 605 DEAYEKNKNYFIEMMGPR 622
D+ E + +++ + P+
Sbjct: 5319 DDEPEGQEFFYVFLTNPQ 5336
Score = 37.4 bits (85), Expect = 0.065
Identities = 48/225 (21%), Positives = 92/225 (40%), Gaps = 43/225 (19%)
Query: 401 DPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGET 460
DP SY V LTVVR G T+ +++ ++ A + GT+ E+
Sbjct: 4051 DPDSY--------VTLTVVRSPGGKG-TVRLEWTIDE---KAKHNLSPLNGTLHFDETES 4098
Query: 461 QKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
QK + + D + EED F ++L ++ E P +G A+
Sbjct: 4099 QKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGS--------------------AS 4138
Query: 521 VTILDDDHA-GIFTFECDTIHV------SESIGVMEVKVLRTSGARGTVIVPFRTVEGTA 573
+ I D A G + H+ ++ G + ++R G G V V +R +
Sbjct: 4139 IIIRGDKRASGEVGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSV 4198
Query: 574 KGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEM 618
+F +T G+L +++++ + I+ ++D+ E+ Y ++
Sbjct: 4199 ----GEFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQL 4239
Score = 37.4 bits (85), Expect = 0.065
Identities = 51/232 (21%), Positives = 92/232 (39%), Gaps = 34/232 (14%)
Query: 400 FDP--CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN-AGADYEFTEGTVVLK 456
FDP +++ E+ G +++ VVR G D+ ++ SA+ G DY TV +
Sbjct: 4402 FDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT-ADFISQSSSASPGGVDYILHGSTVTFQ 4460
Query: 457 PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASP 516
G+ ++ IIDD+ E +E + L+ AVL
Sbjct: 4461 HGQNLSFINISIIDDNESEFEEPIEILLTGA--------------------TGGAVLGRH 4500
Query: 517 CVATVTILDDDHA-GIFTF---ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGT 572
V+ + I D G+ F +I S ++ + + RT G G + V + TV
Sbjct: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
Query: 573 AKGG----GEDFEDTYGELEF--KNDETVKTIHIKVIDDEAYEKNKNYFIEM 618
++ D D L + + + V+TI + + E E + + I++
Sbjct: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKL 4612
Score = 37.0 bits (84), Expect = 0.085
Identities = 35/114 (30%), Positives = 57/114 (50%), Gaps = 10/114 (8%)
Query: 530 GIFTFECDT--IHVSESIGVMEVKVLRTSGARGTVI-VPFRTVEGTAKGGGEDFEDTY-G 585
G+F F + I VSE ++ + V R G +I V ++T G+AK EDFE G
Sbjct: 5003 GVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPL-EDFEPVQNG 5061
Query: 586 ELEFKNDETVKTIHIKVIDDEAYEKNKNYFI-----EMMGPRMVDMSFQKALLL 634
EL F+ +T I +I+D+ E + ++I E+ G + D+++ L L
Sbjct: 5062 ELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIRGLQKFDVNWSPRLNL 5115
Score = 35.8 bits (81), Expect = 0.19
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN----VRIEEEQPEEG 497
D+E T++ GE +++ SV I+DDD E E F+V L+N +I EE+ + G
Sbjct: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTG 5349
Score = 35.0 bits (79), Expect = 0.32
Identities = 50/243 (20%), Positives = 98/243 (40%), Gaps = 31/243 (12%)
Query: 391 PEDFISKVFFDPCSYQCLENCGAVLLT--VVRKGGDMSKTMYVDYKTEDGSANAGADYEF 448
PE K + +P + + G +L+T V R G + M Y + D+
Sbjct: 4646 PETLSKKTYSEPLALE-----GPLLITFFVRRVKGTFGEIMV--YWELSSEFDITEDFLS 4698
Query: 449 TEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL 508
T G + GE++ F V ++ D++ E +E + ++L +V E L L
Sbjct: 4699 TSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAE-------------LDL 4745
Query: 509 PRAVLASPCVATVTILDDDHAGIFTFECD--TIHVSES-IGVMEVKVLRTSGARGTVIVP 565
+++ A +DD G+F D +I + ++ I +++ + R +G G V V
Sbjct: 4746 EKSITWFSVYA-----NDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
Query: 566 FRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVD 625
R + K E+ +L K+ T K + + + N+ ++++ +V
Sbjct: 4801 LR-ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQLVTVMLVG 4859
Query: 626 MSF 628
F
Sbjct: 4860 GRF 4862
Score = 33.1 bits (74), Expect = 1.2
Identities = 14/44 (31%), Positives = 26/44 (59%)
Query: 579 DFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPR 622
DF + GEL F+ E TI + ++DD EK +++ +++ P+
Sbjct: 3586 DFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPK 3629
Score = 32.0 bits (71), Expect = 2.7
Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 1/77 (1%)
Query: 410 NCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGII 469
N V L ++R G + T +G G D G V PGET + + ++
Sbjct: 2250 NSVKVNLPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVTFAPGETIQTLLLEVL 2308
Query: 470 DDDIFEEDEHFFVRLSN 486
DD+ E +E V+L++
Sbjct: 2309 ADDVPEIEEVIQVQLTD 2325
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 68.9 bits (167), Expect = 2e-11
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 38/168 (22%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
+I++ + +IYMF+ ++I+ D F + +++ ++ + V+
Sbjct: 135 IILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGIS-----------------DDVAGA 177
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA G SAPE+ SLI V FIA ++G TIVGSA FN+ +IG+C +R
Sbjct: 178 TFMAAGGSAPELFTSLIGV----FIAHSNVGIGTIVGSAVFNILFVIGMCALF-----SR 228
Query: 196 KIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTL 238
+I +L W +F + Y M++ F V+ WE LL L
Sbjct: 229 EILNL------TWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLL 270
Score = 53.9 bits (128), Expect = 7e-07
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 8/178 (4%)
Query: 711 DEDEDESGEERLPSCFDYVMHFLTVF------WKVLFACVPPTEYCHGWACFAVSILIIG 764
DE+ED+ PS + FL VF W L P+ F SI I
Sbjct: 452 DEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIA 511
Query: 765 MLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTG 824
+ + ++ A G TIG+ + + + +A GTS+PD S A + + D ++ + G
Sbjct: 512 VFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMAVSSSVG 570
Query: 825 SNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRR 882
SN ++ +G+ L W + + Q S G V LF + FV +S+ L + R
Sbjct: 571 SNIFDITVGLPLPWLLYTVIHRFQPVAVS-SNGLFCAIVLLFIMLLFVILSIALCKWR 627
Score = 35.0 bits (79), Expect = 0.32
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)
Query: 781 IGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL 836
+G+ D V F+A G S P+ F S +++ IG + GS N+ IG+
Sbjct: 168 LGISDDVAGATFMAAGGSAPELFTSLIGVF-IAHSNVGIGTIVGSAVFNILFVIGM 222
Score = 32.0 bits (71), Expect = 2.7
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 531 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 578
>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 67.8 bits (164), Expect = 4e-11
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 34/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
Query: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
Query: 577 GEDF----EDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
D+ ED L F +ET KT + +IDD YE+ +++ + + P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Score = 56.6 bits (135), Expect = 1e-07
Identities = 63/238 (26%), Positives = 94/238 (39%), Gaps = 37/238 (15%)
Query: 383 MSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANA 442
M+ V +P D S V+ Y+ E+ G +L+ V R+ GD S+ + V T GSA
Sbjct: 1874 MATVEIVDPGDE-STVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATG 1931
Query: 443 GADYEFTEGTVVLKP-----------GETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEE 491
+ +P ETQK V IIDD ++EE+E F V L
Sbjct: 1932 TISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR------ 1985
Query: 492 EQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH-AGIFTFECDTIHVSESIGVMEV 550
LP+ + A VTIL D + + F HV+ES +EV
Sbjct: 1986 --------------LPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEV 2031
Query: 551 KVLRTS---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
V R ++ V R E + G D+ L+F ++T + ++DD
Sbjct: 2032 CVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
Score = 35.0 bits (79), Expect = 0.32
Identities = 22/88 (25%), Positives = 39/88 (44%)
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
V E +EV + R T + T + TAK + T +++F +T T +
Sbjct: 1784 VDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRV 1843
Query: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSF 628
++I D YE ++ + I + P M + F
Sbjct: 1844 RIIPDNEYETSETFQIILSEPLMAVLEF 1871
>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 67.8 bits (164), Expect = 4e-11
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 34/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
Query: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
Query: 577 GEDF----EDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
D+ ED L F +ET KT + +IDD YE+ +++ + + P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Score = 56.6 bits (135), Expect = 1e-07
Identities = 63/238 (26%), Positives = 94/238 (39%), Gaps = 37/238 (15%)
Query: 383 MSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANA 442
M+ V +P D S V+ Y+ E+ G +L+ V R+ GD S+ + V T GSA
Sbjct: 1874 MATVEIVDPGDE-STVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATG 1931
Query: 443 GADYEFTEGTVVLKP-----------GETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEE 491
+ +P ETQK V IIDD ++EE+E F V L
Sbjct: 1932 TISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR------ 1985
Query: 492 EQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH-AGIFTFECDTIHVSESIGVMEV 550
LP+ + A VTIL D + + F HV+ES +EV
Sbjct: 1986 --------------LPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEV 2031
Query: 551 KVLRTS---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
V R ++ V R E + G D+ L+F ++T + ++DD
Sbjct: 2032 CVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
Score = 35.0 bits (79), Expect = 0.32
Identities = 22/88 (25%), Positives = 39/88 (44%)
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
V E +EV + R T + T + TAK + T +++F +T T +
Sbjct: 1784 VDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRV 1843
Query: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSF 628
++I D YE ++ + I + P M + F
Sbjct: 1844 RIIPDNEYETSETFQIILSEPLMAVLEF 1871
>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 67.8 bits (164), Expect = 4e-11
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 34/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
Query: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
Query: 577 GEDF----EDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
D+ ED L F +ET KT + +IDD YE+ +++ + + P
Sbjct: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
Score = 56.6 bits (135), Expect = 1e-07
Identities = 63/238 (26%), Positives = 94/238 (39%), Gaps = 37/238 (15%)
Query: 383 MSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANA 442
M+ V +P D S V+ Y+ E+ G +L+ V R+ GD S+ + V T GSA
Sbjct: 1874 MATVEIVDPGDE-STVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATG 1931
Query: 443 GADYEFTEGTVVLKP-----------GETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEE 491
+ +P ETQK V IIDD ++EE+E F V L
Sbjct: 1932 TISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR------ 1985
Query: 492 EQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH-AGIFTFECDTIHVSESIGVMEV 550
LP+ + A VTIL D + + F HV+ES +EV
Sbjct: 1986 --------------LPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEV 2031
Query: 551 KVLRTS---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
V R ++ V R E + G D+ L+F ++T + ++DD
Sbjct: 2032 CVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
Score = 35.0 bits (79), Expect = 0.32
Identities = 22/88 (25%), Positives = 39/88 (44%)
Query: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
V E +EV + R T + T + TAK + T +++F +T T +
Sbjct: 1784 VDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRV 1843
Query: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSF 628
++I D YE ++ + I + P M + F
Sbjct: 1844 RIIPDNEYETSETFQIILSEPLMAVLEF 1871
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 64.7 bits (156), Expect = 4e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 711 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 758
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
Query: 759 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 818
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
Query: 819 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 874
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
Score = 60.5 bits (145), Expect = 7e-09
Identities = 41/110 (37%), Positives = 58/110 (52%), Gaps = 22/110 (20%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + IYMF ++I+ D F P+ E + + +E V+
Sbjct: 110 VVLHVLCAIYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 152
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGIC 185
T MA GSSAPE+ S+I V FI GD+G TIVGSA FN+ IIG+C
Sbjct: 153 TFMAAGSSAPELFTSVIGV----FITKGDVGVGTIVGSAVFNILCIIGVC 198
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 837
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
Query: 838 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 866
VA W L + + +A V ++
Sbjct: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
Score = 33.1 bits (74), Expect = 1.2
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ I +G+
Sbjct: 509 DVIMGITFLAAGTSVPDCMASLI-VARQGM--GDMAVSNSIGSNVFDILIGLGL 559
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 64.3 bits (155), Expect = 5e-10
Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 32/174 (18%)
Query: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
+I+YF+ ++YMF+ +SI+ D F+ S+E+I+ ++ V+
Sbjct: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISES------------------LGLSQDVAG 110
Query: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYV-IPDGE 193
T MA GSSAPE++ + + V FI GD+G STI+GSA +N ++GIC +
Sbjct: 111 TTFMAAGSSAPELVTAFLGV----FITKGDIGISTILGSAIYN---LLGICAACGLLSNT 163
Query: 194 TRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
+ +F AA++I A +L + V +EG L L + + VL+
Sbjct: 164 VSTLSCWPLFRDCAAYTISA----AAVLGIIYDNQVYWYEGALLLLIYGLYVLV 213
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 736 FWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAF 795
FWK F F +S + I T I+ + + G T+ + D+V + +A
Sbjct: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
Query: 796 GTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIY 844
GTS+PDT AS A + D ++ N+ GSN ++ L +G+ W + +
Sbjct: 378 GTSIPDTIASVLVARKG-KGDMAMSNIVGSNVFDM-LCLGIPWFIKTAF 424
Score = 35.4 bits (80), Expect = 0.25
Identities = 21/51 (41%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFII 181
+TV LTL+A G+S P+ + S++ V G GD+ S IVGS F+M +
Sbjct: 367 DTVMGLTLLAAGTSIPDTIASVL-VARKG--KGDMAMSNIVGSNVFDMLCL 414
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 62.8 bits (151), Expect = 1e-09
Identities = 64/261 (24%), Positives = 115/261 (44%), Gaps = 49/261 (18%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + +YMF ++I+ D F P+ E + + +E V+
Sbjct: 36 VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 78
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 79 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 132
Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
++ ++ S++ I + +++ + WEGL+ + + +L +
Sbjct: 133 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL--------I 180
Query: 256 LFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KEV 309
+ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 181 MKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKEK 233
Query: 310 DESRREMIRILKDLKQKHPEK 330
+ + + ++ ++ P K
Sbjct: 234 PQYGKNPVVMVDEIMSSSPPK 254
Score = 60.5 bits (145), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 756 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 815
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 451
Query: 816 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 875
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 508
Query: 876 VL 877
VL
Sbjct: 509 VL 510
Score = 35.4 bits (80), Expect = 0.25
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 838
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 71 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 129
Query: 839 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 872
V + W + V ++ +++++ + F+
Sbjct: 130 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 157
Score = 33.5 bits (75), Expect = 0.94
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 422 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 472
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 62.8 bits (151), Expect = 1e-09
Identities = 64/261 (24%), Positives = 115/261 (44%), Gaps = 49/261 (18%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + +YMF ++I+ D F P+ E + + +E V+
Sbjct: 83 VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 125
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 126 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 179
Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
++ ++ S++ I + +++ + WEGL+ + + +L +
Sbjct: 180 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYIL--------I 227
Query: 256 LFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNL----VPLEG--KEV 309
+ Y + + T K + I +P E++ + F DG+ VPL G KE
Sbjct: 228 MKYNVKMQAFFTVKQKSI----ANGNPVNSELEA---GNDFYDGSYDDPSVPLLGQVKEK 280
Query: 310 DESRREMIRILKDLKQKHPEK 330
+ + + ++ ++ P K
Sbjct: 281 PQYGKNPVVMVDEIMSSSPPK 301
Score = 60.5 bits (145), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 756 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 815
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 498
Query: 816 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 875
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 555
Query: 876 VL 877
VL
Sbjct: 556 VL 557
Score = 35.4 bits (80), Expect = 0.25
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 838
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
Query: 839 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 872
V + W + V ++ +++++ + F+
Sbjct: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
Score = 33.5 bits (75), Expect = 0.94
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 469 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 519
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/188 (26%), Positives = 86/188 (45%), Gaps = 28/188 (14%)
Query: 77 VIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNL 136
V+++ + +YMF ++I+ D F P+ E + + +E V+
Sbjct: 83 VLLHILGALYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGA 125
Query: 137 TLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGETR 195
T MA GSS PE+ S+I V FI GD+G TIVGSA FN+ IIG+C G+
Sbjct: 126 TFMAAGSSTPELFASVIGV----FITHGDVGVGTIVGSAVFNILCIIGVCGLFA--GQVV 179
Query: 196 KIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRL 255
++ ++ S++ I + +++ + WEGL+ + + +L+ K
Sbjct: 180 RL----TWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQ 235
Query: 256 LFYKYMHK 263
F+ K
Sbjct: 236 AFFTVKQK 243
Score = 60.5 bits (145), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 756 FAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYA 815
F + L I + + I+ L + G T+G+ D + + F+A GTSVPD AS A Q +
Sbjct: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGL-G 479
Query: 816 DASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCIS 875
D ++ N GSN ++ +G+G+ W + + G +++ L +SV L + V ++
Sbjct: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL--LLGSVALT 536
Query: 876 VL 877
VL
Sbjct: 537 VL 538
Score = 35.4 bits (80), Expect = 0.25
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 11/94 (11%)
Query: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL----AW 838
L + V F+A G+S P+ FAS + + D +G + GS N+ IG+ A
Sbjct: 118 LSEDVAGATFMAAGSSTPELFAS-VIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG 176
Query: 839 SVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFV 872
V + W + V ++ +++++ + F+
Sbjct: 177 QVVRLTW------WAVCRDSVYYTISVIVLIVFI 204
Score = 33.5 bits (75), Expect = 0.94
Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ + +G+
Sbjct: 450 DVIMGITFLAAGTSVPDCMASLI-VARQGL--GDMAVSNTIGSNVFDILVGLGV 500
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 60.8 bits (146), Expect = 5e-09
Identities = 50/172 (29%), Positives = 83/172 (48%), Gaps = 40/172 (23%)
Query: 77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
V+++ ++Y+F+ ++I+ D F+ ++ VIT + + +E V+
Sbjct: 455 VVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQI------------------SEDVAG 496
Query: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGICVYVIPDGET 194
T MA G SAPE+ SLI V FI+ ++G TIVGSA FN+ +IG C +
Sbjct: 497 ATFMAAGGSAPELFTSLIGV----FISHSNVGIGTIVGSAVFNILFVIGTCSLF-----S 547
Query: 195 RKIKHLRVFFITAAWSIFAYIWLY-----MILAVFSPGVVQVWEGLLTLFFF 241
R+I +L W +F + Y M++ F ++ WE LL L +
Sbjct: 548 REILNL------TWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAY 593
Score = 50.4 bits (119), Expect = 7e-06
Identities = 46/178 (25%), Positives = 77/178 (43%), Gaps = 15/178 (8%)
Query: 711 DEDEDESGEERLPSCFDY--------VMHFLTVFWKVLFACVPPTEYCHGWACFAV---- 758
+E+E+E G E P D+ + FL L+ VP F
Sbjct: 885 EEEEEEKGNEE-PLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLG 943
Query: 759 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 818
SI+ I M + ++ A G TIG+ + + + +A GTS+PD S A + + D +
Sbjct: 944 SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGL-GDMA 1002
Query: 819 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISV 876
+ + GSN ++ +G+ + W + ++ LQ S G V LF + FV S+
Sbjct: 1003 VSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVS-SNGLFCAIVLLFLMLLFVISSI 1059
Score = 32.0 bits (71), Expect = 2.7
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 130 NETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFI 180
+E + LT++A G+S P+++ S+I V G GD+ S+ VGS F++ +
Sbjct: 969 SEEIMGLTILAAGTSIPDLITSVI-VARKGL--GDMAVSSSVGSNIFDITV 1016
>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
[Homo sapiens]
Length = 3169
Score = 60.5 bits (145), Expect = 7e-09
Identities = 56/229 (24%), Positives = 91/229 (39%), Gaps = 33/229 (14%)
Query: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Y + L V+++ G + +T ++ T D +A D++ + V PG+T+
Sbjct: 1777 YYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQTRAT 1836
Query: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
+ V I+ D E+ E F V LS P + A L P VATV I
Sbjct: 1837 WRVRILSDGEHEQSETFQVVLSE-------------PVL--------AALEFPTVATVEI 1875
Query: 524 LDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKG-------G 576
+D V E +G + + + R+ ++V T +GTA G
Sbjct: 1876 VDPGDEPTVFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLS 1935
Query: 577 GEDF----EDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
D+ ED + F DE K I +IDD YE+ + + + + P
Sbjct: 1936 YSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
Score = 59.7 bits (143), Expect = 1e-08
Identities = 65/270 (24%), Positives = 110/270 (40%), Gaps = 34/270 (12%)
Query: 375 EQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYK 434
E +K S+++ +D P K+ F Y E+ G ++ T++ + GD+ V
Sbjct: 2112 EPSKATVSINDSVSDLP-----KMQFKERIYTGSESDGQIV-TMIHRTGDVQYRSSVRCY 2165
Query: 435 TEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIE 490
T GSA D+E T + PGET+K + ++DD ++EE E +R+
Sbjct: 2166 TRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEE-------LRLV 2218
Query: 491 EEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSE-----SI 545
P+ P A + + I DD + F V+E
Sbjct: 2219 LGTPQSNSPFG---------AAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPKEPGES 2269
Query: 546 GVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
V+ + V+R IV T +G+A G ED+ E+EFK ET + I+V D
Sbjct: 2270 VVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-EDYHPVSEEIEFKEGETQHVVEIEVTFD 2328
Query: 606 EAYEKNKNYFIEMMGPR--MVDMSFQKALL 633
E + + + + + +M KA++
Sbjct: 2329 GVREMREAFTVHLKPDENMIAEMQLTKAIV 2358
Score = 55.8 bits (133), Expect = 2e-07
Identities = 61/233 (26%), Positives = 96/233 (41%), Gaps = 42/233 (18%)
Query: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN------- 441
DEP VF Y E+ G + + + R+ GD+S+ + V T+ G+A
Sbjct: 1880 DEPT-----VFIPQSKYSVEEDVGELFIPI-RRSGDVSQELMVVCYTQQGTATGTVPTSV 1933
Query: 442 -AGADY----EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
+ +DY E V E +K + IIDD ++EE+E F V L
Sbjct: 1934 LSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLL------------ 1981
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGIFTFECDTIHVSESIGVMEVKVLRT 555
S+P+ + + A VTI+ D D IF F V ES G +EV+V RT
Sbjct: 1982 --------SMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAGYVEVQVWRT 2033
Query: 556 S---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
+V V R + + G D+ L+F ++ + + ++DD
Sbjct: 2034 GTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVILDD 2086
Score = 45.1 bits (105), Expect = 3e-04
Identities = 65/265 (24%), Positives = 109/265 (41%), Gaps = 28/265 (10%)
Query: 399 FFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDY---KTEDGSANAGADYEFTEGTVVL 455
+F Y E+ G V + V R G D+SK+ V KT+ SA+AG DY +
Sbjct: 2011 YFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDF 2070
Query: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
PG + V I+DD L +E + E + +P+ A L
Sbjct: 2071 APGVNMQPVRVVILDD------------LGQPALEGIEKFE-----LVLRMPM-NAALGE 2112
Query: 516 PCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
P ATV+I D F+ SES G + + RT + V T +G+A+
Sbjct: 2113 PSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ 2172
Query: 575 GGGEDFEDTYGE----LEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQK 630
DFE+ + F ET K ++++DD YE+ + + ++G + F
Sbjct: 2173 -VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRL-VLGTPQSNSPFGA 2230
Query: 631 ALLLSPDRKLTMEEEEAKRIAEMGK 655
A+ + + + ++ K + + G+
Sbjct: 2231 AVGEQNETLIRIRDDADKTVIKFGE 2255
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 57.8 bits (138), Expect = 5e-08
Identities = 70/271 (25%), Positives = 107/271 (39%), Gaps = 46/271 (16%)
Query: 396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA---------DY 446
S + F SY E G+V +TV R G ++++ V +TE G+A++ + DY
Sbjct: 2552 SLISFKYTSYNVSEKAGSVSVTVQRTG-NLNQYAIVLCRTEQGTASSSSRVSSQPGQQDY 2610
Query: 447 EFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSL 506
G V E K ++ I DDD+FE E F V LS MP
Sbjct: 2611 VEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVELS------------MP------- 2651
Query: 507 PLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF 566
A+L A V I D + F+ V+ES G + + R A V
Sbjct: 2652 --AYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAIC 2709
Query: 567 RTVEGTAKG-------GGEDFE----DTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYF 615
TV +A G G DF+ + F T+ T + +IDD YE+ + +
Sbjct: 2710 YTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFE 2769
Query: 616 IEMM----GPRMVDMSFQKALLLSPDRKLTM 642
I + R+ ++ K L+ P+ T+
Sbjct: 2770 IALADASDNARIGRVATAKVLISGPNDASTV 2800
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/154 (29%), Positives = 65/154 (42%), Gaps = 24/154 (15%)
Query: 381 SSMSEVHTDEPEDFISKVFFDPCSYQCLENCG----AVLLTVVRKGGDMSKTMYVDYKTE 436
++M+ + ED + F+ +YQ E G A+L V + GD ++T V T
Sbjct: 3025 NNMATITISNDED-APTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTR 3083
Query: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
DGSA +G DY + PG F V I+ ++ E E F + L + P E
Sbjct: 3084 DGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLG-----PDDPVE 3138
Query: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAG 530
AVL ATVTILD + AG
Sbjct: 3139 --------------AVLGDVTTATVTILDQEAAG 3158
Score = 47.8 bits (112), Expect = 5e-05
Identities = 54/217 (24%), Positives = 93/217 (42%), Gaps = 27/217 (12%)
Query: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGT----VVLKPGETQKEFSVGII 469
VL + + GD+S V T+ SA D+E + + G+ K +V I
Sbjct: 2935 VLHVPITRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIH 2994
Query: 470 DDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA 529
DD +FE +E F V L G+P S A + +AT+TI +D+ A
Sbjct: 2995 DDSMFEPEEQFRVYL------------GLPLGNHWS----GARIGKNNMATITISNDEDA 3038
Query: 530 GIFTFECDTIHVSE-----SIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTY 584
FE V E +I ++ +KV+R T V T +G+A+ G D+
Sbjct: 3039 PTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQ-SGVDYYPKS 3097
Query: 585 GELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
L+F ++++ +E E ++++ + ++GP
Sbjct: 3098 RVLKFSPGVDHIFFKVEILSNEDREWHESFSL-VLGP 3133
Score = 42.7 bits (99), Expect = 0.002
Identities = 56/230 (24%), Positives = 87/230 (37%), Gaps = 33/230 (14%)
Query: 396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKT---EDGSANAGADYEFTEGT 452
S V ++ E+ G V + V+R G D+S V T + SA G DY +
Sbjct: 2798 STVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRK 2857
Query: 453 VVLKPGETQKEFSVGIIDD---DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLP 509
V PG ++ ++ I+DD + E E F V LS+ +
Sbjct: 2858 VEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQ--------------------- 2896
Query: 510 RAVLASPCVATVTILDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRT 568
A L P A + I D F D + V E GV+ V + R+ V T
Sbjct: 2897 GAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYT 2956
Query: 569 VEGTAKGGGEDFEDTY----GELEFKNDETVKTIHIKVIDDEAYEKNKNY 614
+A+ EDFE+ + F + VK + + DD +E + +
Sbjct: 2957 QSHSAQ-VMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQF 3005
>gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]
Length = 1805
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 487 VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
+R E++ ++ + AI +P A L V +TI+ + + +FE VS
Sbjct: 950 IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006
Query: 547 VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVID 604
V + V+R G V +RT +GTA+ G D+ GEL F+ E K + +K+++
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLE 1063
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
+ V+R+ D K+ V Y+T+DG+A DY EG ++ +PGE KE V +++ D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 472 DIF--EEDEHFFVRLSN 486
+ + F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085
>gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]
Length = 1822
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 487 VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
+R E++ ++ + AI +P A L V +TI+ + + +FE VS
Sbjct: 950 IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006
Query: 547 VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVID 604
V + V+R G V +RT +GTA+ G D+ GEL F+ E K + +K+++
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLE 1063
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
+ V+R+ D K+ V Y+T+DG+A DY EG ++ +PGE KE V +++ D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 472 DIF--EEDEHFFVRLSN 486
+ + F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085
>gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]
Length = 1752
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 4/118 (3%)
Query: 487 VRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIG 546
+R E++ ++ + AI +P A L V +TI+ + + +FE VS
Sbjct: 950 IRPEDDDEKQLLVEAI--DVPAGTATLGRRLV-NITIIKEQARDVVSFEQPEFSVSRGDQ 1006
Query: 547 VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVID 604
V + V+R G V +RT +GTA+ G D+ GEL F+ E K + +K+++
Sbjct: 1007 VARIPVIRRVLDGGKSQVSYRTQDGTAQ-GNRDYIPVEGELLFQPGEAWKELQVKLLE 1063
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 7/77 (9%)
Query: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIID----D 471
+ V+R+ D K+ V Y+T+DG+A DY EG ++ +PGE KE V +++ D
Sbjct: 1010 IPVIRRVLDGGKSQ-VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 472 DIF--EEDEHFFVRLSN 486
+ + F V+LSN
Sbjct: 1069 SLLRGRQVRRFHVQLSN 1085
>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
Length = 2179
Score = 41.2 bits (95), Expect = 0.005
Identities = 26/92 (28%), Positives = 45/92 (48%), Gaps = 2/92 (2%)
Query: 396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVV- 454
S + + Y+ EN G + L ++R+G M +V K SA G D+ ++
Sbjct: 1741 SHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSA-FVGIKVNQVSAAVGKDFTVIPSKLIQ 1799
Query: 455 LKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN 486
PG + K +++ I D + E+DE F V L++
Sbjct: 1800 FDPGMSTKMWNIAITYDGLEEDDEVFEVILNS 1831
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 34.7 bits (78), Expect = 0.42
Identities = 47/193 (24%), Positives = 75/193 (38%), Gaps = 19/193 (9%)
Query: 627 SFQKALLLSPDRKLTMEEEEAKRI--AEMGKPVLGEHPKLEVIIEESYEF----KTTVDK 680
SF +LL P + + + K + A P+L E PK++ I + +
Sbjct: 1175 SFSTEVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSEN 1234
Query: 681 LIKKTNLAL--VVGTHSWRDQFMEAITVSAAGDEDE-----DESGEERLPSCFDYVMHFL 733
++ T++ + V T ++ +T+S A ++ E ES + +PS + F
Sbjct: 1235 MLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQVVPSLYSNDELFQ 1294
Query: 734 TVFWKVLFACVPPTEYCHGWACFAVSILIIGM-LTAIIGDLASHFGCTIGLKDSVTAVVF 792
T ++ A P G FA +L I L +I L K SVT VF
Sbjct: 1295 TANLEINQAHPPK-----GRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVF 1349
Query: 793 VAFGTSVPDTFAS 805
T DTF S
Sbjct: 1350 AGIPTVASDTFVS 1362
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 34.3 bits (77), Expect = 0.55
Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)
Query: 766 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 817
L I+G A+ F C T+ L +V V F+AFG PD F++ A A
Sbjct: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
Query: 818 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 877
++G + G+ V + +A + ++ ++A F +F + A ++
Sbjct: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219
Query: 878 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 921
L+R R L LG ++ L++ Y++ L + Y
Sbjct: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251
Score = 32.0 bits (71), Expect = 2.7
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 745 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 804
P + + F S L I + ++ G L ++V + +A+G S+ D F+
Sbjct: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
Query: 805 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 836
A Q Y + G N+ +G+GL
Sbjct: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,488,468
Number of Sequences: 37866
Number of extensions: 1533136
Number of successful extensions: 4352
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 4121
Number of HSP's gapped (non-prelim): 134
length of query: 925
length of database: 18,247,518
effective HSP length: 112
effective length of query: 813
effective length of database: 14,006,526
effective search space: 11387305638
effective search space used: 11387305638
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.