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Search of human proteins with 110347423
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110347423 spondin 1, extracellular matrix protein [Homo
sapiens]
(807 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens] 1707 0.0
gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens] 173 5e-43
gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens] 173 5e-43
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ... 144 4e-34
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ... 129 8e-30
gi|118572606 hemicentin 1 [Homo sapiens] 128 2e-29
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 120 4e-27
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 120 4e-27
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 117 4e-26
gi|147904700 semaphorin 5A [Homo sapiens] 112 1e-24
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 110 5e-24
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 109 9e-24
gi|134031945 SCO-spondin [Homo sapiens] 103 8e-22
gi|4505737 complement factor properdin precursor [Homo sapiens] 102 1e-21
gi|223671861 complement factor properdin precursor [Homo sapiens] 102 1e-21
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 98 3e-20
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 97 8e-20
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 94 7e-19
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 92 1e-18
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 91 6e-18
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 83 1e-15
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 82 2e-15
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 80 8e-15
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 80 8e-15
gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens] 80 8e-15
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 77 8e-14
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 76 1e-13
gi|27436940 reelin isoform b [Homo sapiens] 73 9e-13
gi|27436938 reelin isoform a [Homo sapiens] 73 9e-13
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 70 8e-12
>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
Length = 807
Score = 1707 bits (4420), Expect = 0.0
Identities = 807/807 (100%), Positives = 807/807 (100%)
Query: 1 MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTE 60
MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTE
Sbjct: 1 MRLSPAPLKLSRTPALLALALPLAAALAFSDETLDKVPKSEGYCSRILRAQGTRREGYTE 60
Query: 61 FSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEE 120
FSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEE
Sbjct: 61 FSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENREGDKEEDHAGTFQIIDEE 120
Query: 121 ETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKK 180
ETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKK
Sbjct: 121 ETQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCVILKASIVQKRIIYFQDEGSLTKK 180
Query: 181 LCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHS 240
LCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHS
Sbjct: 181 LCEQDSTFDGVTDKPILDCCACGTAKYRLTFYGNWSEKTHPKDYPRRANHWSAIIGGSHS 240
Query: 241 KNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAA 300
KNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAA
Sbjct: 241 KNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWPAWQPLNVRAA 300
Query: 301 PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSG 360
PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSG
Sbjct: 301 PSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDLIPWDAGTDSG 360
Query: 361 VTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPD 420
VTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPD
Sbjct: 361 VTYESPNKPTIPQEKIRPLTSLDHPQSPFYDPEGGSITQVARVVIERIARKGEQCNIVPD 420
Query: 421 NVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC 480
NVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC
Sbjct: 421 NVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC 480
Query: 481 PDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTL 540
PDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTL
Sbjct: 481 PDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTL 540
Query: 541 PTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS 600
PTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS
Sbjct: 541 PTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS 600
Query: 601 QAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKC 660
QAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKC
Sbjct: 601 QAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKC 660
Query: 661 MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC 720
MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC
Sbjct: 661 MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC 720
Query: 721 LRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMT 780
LRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMT
Sbjct: 721 LRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMT 780
Query: 781 VKKRFKSSQFTSCKDKKEIRACNVHPC 807
VKKRFKSSQFTSCKDKKEIRACNVHPC
Sbjct: 781 VKKRFKSSQFTSCKDKKEIRACNVHPC 807
>gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens]
Length = 331
Score = 173 bits (439), Expect = 5e-43
Identities = 113/331 (34%), Positives = 164/331 (49%), Gaps = 21/331 (6%)
Query: 176 SLTKKLCEQDSTFDGVTDKPILD---CCACGTAKYRLTFYGNWSEKTHPKDYP--RRANH 230
+L K LC G +P+ C A AKY +TF G WS+ PK YP R
Sbjct: 9 ALGKALCALLLATLGAAGQPLGGESICSARAPAKYSITFTGKWSQTAFPKQYPLFRPPAQ 68
Query: 231 WSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWP 290
WS+++G +HS +Y +W Y S G++ AE G + +EI + + E L + A P
Sbjct: 69 WSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEI-EAAGEALQSVHAVFSAP 127
Query: 291 AWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDL 350
A + SAE V R L+SF+ + PSPDW VG+ + DLC + W ++ DL
Sbjct: 128 AVP--SGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGD-RWREQAALDL 184
Query: 351 IPWDAGTDSGVTYESPNKPTIPQEKIRPLTSL--DHPQSPFYDPEGGSITQVARVVIERI 408
P+DAGTDSG T+ SPN TIPQ+ + +TS HP + FY P ++ +ARV + R+
Sbjct: 185 YPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRL 244
Query: 409 ARKGEQCNIVPDNV----DDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKR 464
R+ + I P V D+ + D A +TP C S WS W C G +
Sbjct: 245 -RQSPRAFIPPAPVLPSRDNEIVDSA----SVPETPLDCEVSLWSSWGLCGGHCGRLGTK 299
Query: 465 MRQRMLKAQ-LDLSVPCPDTQDFQPCMGPGC 494
R R ++ Q + PCP+ ++ C+ C
Sbjct: 300 SRTRYVRVQPANNGSPCPELEEEAECVPDNC 330
Score = 63.9 bits (154), Expect = 6e-10
Identities = 27/72 (37%), Positives = 42/72 (58%), Gaps = 1/72 (1%)
Query: 651 NEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGK-GHVIRTRMIQMEPQFGGAPCPET 709
+ D E V+ +PE P+DCE++ WS W C CG+ G RTR ++++P G+PCPE
Sbjct: 260 SRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPEL 319
Query: 710 VQRKKCRIRKCL 721
+ +C C+
Sbjct: 320 EEEAECVPDNCV 331
Score = 40.0 bits (92), Expect = 0.009
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 9/61 (14%)
Query: 502 CTMSEWITWSPCSISCG-MGMRSRERYVKQFP-EDGSVCTLPTEETEKCTVNEECSPSSC 559
C +S W +W C CG +G +SR RYV+ P +GS C EE EC P +C
Sbjct: 278 CEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEA-------ECVPDNC 330
Query: 560 L 560
+
Sbjct: 331 V 331
Score = 39.3 bits (90), Expect = 0.015
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 555 SPSSCLMTEWGEWDECSATCG-MGMKKRHRMIKMNPA-DGSMCKAETSQAEKCMMPEC 610
+P C ++ W W C CG +G K R R +++ PA +GS C +AE C+ C
Sbjct: 274 TPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAE-CVPDNC 330
Score = 31.6 bits (70), Expect = 3.1
Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
Query: 613 IPCLLSPWSEWSDCSVTCGK-GMRTRQRMLK-SLAELGDCNEDLEQVEKCMLPEC 665
+ C +S WS W C CG+ G ++R R ++ A G +LE+ +C+ C
Sbjct: 276 LDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNC 330
>gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens]
Length = 331
Score = 173 bits (439), Expect = 5e-43
Identities = 113/331 (34%), Positives = 164/331 (49%), Gaps = 21/331 (6%)
Query: 176 SLTKKLCEQDSTFDGVTDKPILD---CCACGTAKYRLTFYGNWSEKTHPKDYP--RRANH 230
+L K LC G +P+ C A AKY +TF G WS+ PK YP R
Sbjct: 9 ALGKALCALLLATLGAAGQPLGGESICSARAPAKYSITFTGKWSQTAFPKQYPLFRPPAQ 68
Query: 231 WSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQSDEVLTVIKAKAQWP 290
WS+++G +HS +Y +W Y S G++ AE G + +EI + + E L + A P
Sbjct: 69 WSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEI-EAAGEALQSVHAVFSAP 127
Query: 291 AWQPLNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAEDLCTKECGWVQKVVQDL 350
A + SAE V R L+SF+ + PSPDW VG+ + DLC + W ++ DL
Sbjct: 128 AVP--SGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGD-RWREQAALDL 184
Query: 351 IPWDAGTDSGVTYESPNKPTIPQEKIRPLTSL--DHPQSPFYDPEGGSITQVARVVIERI 408
P+DAGTDSG T+ SPN TIPQ+ + +TS HP + FY P ++ +ARV + R+
Sbjct: 185 YPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRL 244
Query: 409 ARKGEQCNIVPDNV----DDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKR 464
R+ + I P V D+ + D A +TP C S WS W C G +
Sbjct: 245 -RQSPRAFIPPAPVLPSRDNEIVDSA----SVPETPLDCEVSLWSSWGLCGGHCGRLGTK 299
Query: 465 MRQRMLKAQ-LDLSVPCPDTQDFQPCMGPGC 494
R R ++ Q + PCP+ ++ C+ C
Sbjct: 300 SRTRYVRVQPANNGSPCPELEEEAECVPDNC 330
Score = 63.9 bits (154), Expect = 6e-10
Identities = 27/72 (37%), Positives = 42/72 (58%), Gaps = 1/72 (1%)
Query: 651 NEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGK-GHVIRTRMIQMEPQFGGAPCPET 709
+ D E V+ +PE P+DCE++ WS W C CG+ G RTR ++++P G+PCPE
Sbjct: 260 SRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPEL 319
Query: 710 VQRKKCRIRKCL 721
+ +C C+
Sbjct: 320 EEEAECVPDNCV 331
Score = 40.0 bits (92), Expect = 0.009
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 9/61 (14%)
Query: 502 CTMSEWITWSPCSISCG-MGMRSRERYVKQFP-EDGSVCTLPTEETEKCTVNEECSPSSC 559
C +S W +W C CG +G +SR RYV+ P +GS C EE EC P +C
Sbjct: 278 CEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEA-------ECVPDNC 330
Query: 560 L 560
+
Sbjct: 331 V 331
Score = 39.3 bits (90), Expect = 0.015
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 555 SPSSCLMTEWGEWDECSATCG-MGMKKRHRMIKMNPA-DGSMCKAETSQAEKCMMPEC 610
+P C ++ W W C CG +G K R R +++ PA +GS C +AE C+ C
Sbjct: 274 TPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAE-CVPDNC 330
Score = 31.6 bits (70), Expect = 3.1
Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
Query: 613 IPCLLSPWSEWSDCSVTCGK-GMRTRQRMLK-SLAELGDCNEDLEQVEKCMLPEC 665
+ C +S WS W C CG+ G ++R R ++ A G +LE+ +C+ C
Sbjct: 276 LDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNC 330
>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
sapiens]
Length = 1577
Score = 144 bits (362), Expect = 4e-34
Identities = 127/434 (29%), Positives = 190/434 (43%), Gaps = 92/434 (21%)
Query: 432 EEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQ-LDLSVPCP--------D 482
+EK P C S+WS W +CSSS C G R+R + LK + + PCP
Sbjct: 959 QEKCVIPCPFDCKLSDWSSWGSCSSS-CGIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQ 1017
Query: 483 TQDFQPCMGPGCSDEDGSTCTMSEWIT--WSPCSIS-------CGMGMRSRE-RYVKQFP 532
+ PC S C W+ WS C I+ CG G +SR+ R V
Sbjct: 1018 VHEAVPCY---------SECNQYSWVVEHWSSCKINNELRSLRCGGGTQSRKIRCVNTAD 1068
Query: 533 -EDGSVCTLPTEETEKCTVNEECS---PSSCLMTEWGEWDECSATCGMGMKKRHRMIKMN 588
E G+V + + E + CS P+ C+M+EWG W +C +C +R +
Sbjct: 1069 GEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWGLWSKCPQSCDPHTMQRRTRHLLR 1128
Query: 589 PADGSMCKAETSQAEKCMMPE-CHTIPCLLSPWSEWSDCSVT----CGKGMRTRQRMLKS 643
P+ S AE SQ + C++ E C L +EWS C ++ CG+G+RT R+L
Sbjct: 1129 PSLNSRTCAEDSQVQPCLLNENCFQFQYNL---TEWSTCQLSENAPCGQGVRT--RLLSC 1183
Query: 644 LAELG------DCNE-DLEQVEKCMLP---ECPIDCELTEWSQWSECNKSCGK-GHVIRT 692
+ G C + +LE+ ++ +P EC ++C+L+ W+ W+EC+++CG G + RT
Sbjct: 1184 VCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGRMSRT 1243
Query: 693 RMIQMEPQFGGAPCP-ETVQRKKCRIRKC----LRNPSIQKLRWREARE----------- 736
R I M Q G PCP E Q K C + C L N S KL + E
Sbjct: 1244 RFIIMPTQGEGRPCPTELTQEKTCPVTPCYSWVLGNWSACKLEGGDCGEGVQIRSLSCMV 1303
Query: 737 -----SRRSEQLKEESEGEQ--------------FPG-CRMRPWTAWSECTKLCGGGIQE 776
S + ++++ GE PG C + W+ WS C C G
Sbjct: 1304 HSGSISHAAGRVEDALCGEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDG--R 1361
Query: 777 RYMTVKKRFKSSQF 790
+ TV ++ +S F
Sbjct: 1362 SFETVGRQSRSRTF 1375
Score = 109 bits (272), Expect = 1e-23
Identities = 107/453 (23%), Positives = 177/453 (39%), Gaps = 105/453 (23%)
Query: 441 ETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGS 500
E C ++ WS ++ CS++ C+ K R+R L + C D+ D P + +
Sbjct: 839 EDCTFTAWSKFTPCSTN-CEATKS-RRRQLTGKSRKKEKCQDS-DLYPLV-------ETE 888
Query: 501 TCTMSEWIT-----WSPC------------------SISCGMGMRSRERYVKQF---PED 534
C E+I+ WS C S CG G+R R P D
Sbjct: 889 LCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFRAVACSDKNGRPVD 948
Query: 535 GSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSM 594
S C+ EKC + P C +++W W CS++CG+G++ R + +K P +G
Sbjct: 949 PSFCSSSGYIQEKCVIP---CPFDCKLSDWSSWGSCSSSCGIGVRIRSKWLKEKPYNGGR 1005
Query: 595 -C-------KAETSQAEKCMMPECHTIPCLLSPWSEWSDC-------SVTCGKGMRTRQR 639
C +A+ +A C EC+ ++ WS C S+ CG G ++R+
Sbjct: 1006 PCPKLDLKNQAQVHEAVPCYS-ECNQYSWVVE---HWSSCKINNELRSLRCGGGTQSRKI 1061
Query: 640 MLKSLAELGD--------CNEDL--EQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHV 689
+ A+ G+ CN+D + + C L CP +C ++EW WS+C +SC +
Sbjct: 1062 RCVNTAD-GEGGAVDSNLCNQDEIPPETQSCSLM-CPNECVMSEWGLWSKCPQSCDPHTM 1119
Query: 690 IRTRMIQMEPQFGGAPCPETVQRKKCRIRK-CLR----------------NPSIQKLRWR 732
R + P C E Q + C + + C + P Q +R R
Sbjct: 1120 QRRTRHLLRPSLNSRTCAEDSQVQPCLLNENCFQFQYNLTEWSTCQLSENAPCGQGVRTR 1179
Query: 733 -----------------EARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCG-GGI 774
E + +++ E C++ WTAW+EC++ CG GG
Sbjct: 1180 LLSCVCSDGKPVSMDQCEQHNLEKPQRMSIPCLVECVVNCQLSGWTAWTECSQTCGHGGR 1239
Query: 775 QERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
R + + + + + C V PC
Sbjct: 1240 MSRTRFIIMPTQGEGRPCPTELTQEKTCPVTPC 1272
Score = 105 bits (263), Expect = 1e-22
Identities = 108/461 (23%), Positives = 175/461 (37%), Gaps = 123/461 (26%)
Query: 443 CIYSNWSPWSACSSSTCDKG----KRMRQRML-KAQLDLSVPCPDT-QDFQPCMGPGCSD 496
CI + +S W+ C C G K+ R R++ + + CPDT + + C
Sbjct: 707 CIVTAFSEWTPCPRM-CQAGNATVKQSRYRIIIQEAANGGQECPDTLYEEREC------- 758
Query: 497 EDGSTCTMSEWIT--WSPC--------------SISCGMGMRSRERYVKQFPEDGSV--- 537
ED S C + W WSPC S +CG G+++R V +D
Sbjct: 759 EDVSLCPVYRWKPQKWSPCILVPESVWQGITGSSEACGKGLQTRA--VSCISDDNRSAEM 816
Query: 538 --CTLPTEE----TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPAD 591
C T ++CTV C C T W ++ CS C +R ++
Sbjct: 817 MECLKQTNGMPLLVQECTV--PCR-EDCTFTAWSKFTPCSTNCEATKSRRRQL-----TG 868
Query: 592 GSMCKAETSQAEKCMMPECHTIPC---LLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELG 648
S K + ++ + E PC + P+ WSDC + +G R R L+ A+
Sbjct: 869 KSRKKEKCQDSDLYPLVETELCPCDEFISQPYGNWSDCILP--EGRREPHRGLRVQADSK 926
Query: 649 DCNEDLEQ------------------------VEKCMLPECPIDCELTEWSQWSECNKSC 684
+C E L EKC++P CP DC+L++WS W C+ SC
Sbjct: 927 ECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIP-CPFDCKLSDWSSWGSCSSSC 985
Query: 685 GKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRK--------------------CLRNP 724
G G IR++ ++ +P GG PCP+ + + ++ + C N
Sbjct: 986 GIGVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPCYSECNQYSWVVEHWSSCKINN 1045
Query: 725 SIQKLRWREARESRRSEQLK-EESEG----------EQFP------------GCRMRPWT 761
++ LR +SR+ + + EG ++ P C M W
Sbjct: 1046 ELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLMCPNECVMSEWG 1105
Query: 762 AWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRAC 802
WS+C + C +R R S +C + +++ C
Sbjct: 1106 LWSKCPQSCDPHTMQRRTRHLLR-PSLNSRTCAEDSQVQPC 1145
Score = 102 bits (254), Expect = 1e-21
Identities = 109/419 (26%), Positives = 166/419 (39%), Gaps = 89/419 (21%)
Query: 443 CIYSNWSPWSACSSSTCD-----KGKRMRQR-MLKAQLDLSVPCPDTQDFQPCMGPGCSD 496
CI S+WS W C C KG R RQR +L + CP + PC P C
Sbjct: 454 CIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCY- 512
Query: 497 EDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPED---GSVCTLPTE-ETEKCTVNE 552
SE I + P CG+G R + + + GS+C +P E + C +
Sbjct: 513 ----RWLASEGICF-PDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSCEI-- 565
Query: 553 ECSPSSCLMTEWGEWDECSATCGM----GMKKRHRMIKMNPADGSM-CKAETSQAEKCMM 607
C C+++EW EW CS +C G + R R I +G C + E +
Sbjct: 566 PCR-MDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRL- 623
Query: 608 PECHTIPCLLSPW--SEWSDCS-----------------VTCGKGMRTRQRMLKSLAELG 648
C+ C+ W S W CS TCG G++TR R+ + +G
Sbjct: 624 --CNDHSCMQLHWETSPWGPCSEDTLVTALNATIGWNGEATCGVGIQTR-RVFCVKSHVG 680
Query: 649 D-----CNEDL--EQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVI----RTRMIQM 697
C + E V C LP C DC +T +S+W+ C + C G+ R R+I
Sbjct: 681 QVMTKRCPDSTRPETVRPCFLP-CKKDCIVTAFSEWTPCPRMCQAGNATVKQSRYRIIIQ 739
Query: 698 EPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRM 757
E GG CP+T+ + R+C RW+ +++ C +
Sbjct: 740 EAANGGQECPDTLYEE----RECEDVSLCPVYRWKP----------------QKWSPCIL 779
Query: 758 RPWTAWSECT---KLCGGGIQERYMT-VKKRFKSSQFTSCKDKKE-----IRACNVHPC 807
P + W T + CG G+Q R ++ + +S++ C + ++ C V PC
Sbjct: 780 VPESVWQGITGSSEACGKGLQTRAVSCISDDNRSAEMMECLKQTNGMPLLVQECTV-PC 837
Score = 102 bits (254), Expect = 1e-21
Identities = 88/324 (27%), Positives = 133/324 (41%), Gaps = 61/324 (18%)
Query: 440 PETCIYSNWSPWSACSSSTCDKG--KRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDE 497
P C+ S W WS C S CD +R + +L+ L+ S C + QPC+
Sbjct: 1096 PNECVMSEWGLWSKCPQS-CDPHTMQRRTRHLLRPSLN-SRTCAEDSQVQPCLL------ 1147
Query: 498 DGSTCTMSEW--ITWSPCSIS----CGMGMRSRERYVKQFPEDGSVCTL----------P 541
C ++ WS C +S CG G+R+R + DG ++ P
Sbjct: 1148 -NENCFQFQYNLTEWSTCQLSENAPCGQGVRTR--LLSCVCSDGKPVSMDQCEQHNLEKP 1204
Query: 542 TEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMG--MKKRHRMIKMNPADGSMCKAET 599
+ C V EC + C ++ W W ECS TCG G M + +I +G C E
Sbjct: 1205 QRMSIPCLV--ECVVN-CQLSGWTAWTECSQTCGHGGRMSRTRFIIMPTQGEGRPCPTEL 1261
Query: 600 SQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEK 659
+Q + C + C++ +L WS CG+G++ R L + G + +VE
Sbjct: 1262 TQEKTCPVTPCYS--WVLGNWSACKLEGGDCGEGVQIRS--LSCMVHSGSISHAAGRVED 1317
Query: 660 CMLPE---------------CPIDCELTEWSQWSECNKSC--GK-----GHVIRTRMIQM 697
+ E CP DC LTEWS+WS C +C G+ G R+R +
Sbjct: 1318 ALCGEMPFQDSILKQLCSVPCPGDCHLTEWSEWSTCELTCIDGRSFETVGRQSRSRTFII 1377
Query: 698 EPQFGGAPCPETV-QRKKCRIRKC 720
+ CP+ V + + C KC
Sbjct: 1378 QSFENQDSCPQQVLETRPCTGGKC 1401
Score = 86.7 bits (213), Expect = 8e-17
Identities = 109/429 (25%), Positives = 162/429 (37%), Gaps = 93/429 (21%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGK-----RMRQRMLKAQ-LDLSVPCPDTQDFQPCMGPG 493
P+ C S WS WS CS TC G R R R +K + CP+ + + C+ G
Sbjct: 303 PKDCETSQWSSWSPCSK-TCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEG 361
Query: 494 CSDEDGSTCTMSEWIT--WSPCSIS----------------CGMGMRSRERYVKQF---- 531
E C W T W C +S CG G+++RE Y Q
Sbjct: 362 ---ELLQQCPRYSWRTSEWKECQVSLLLEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAA 418
Query: 532 ----------PEDGSVCTLPTE-ETEKCTVNEECSPSSCLMTEWGEWDEC-SATCG---- 575
P + ++C P ++ C + CS + C+++ W W C C
Sbjct: 419 AALRAKEVSRPVEKALCVGPAPLPSQLCNI--PCS-TDCIVSSWSAWGLCIHENCHDPQG 475
Query: 576 -MGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGM 634
G + R R + M + ++ C P C+ L S + D CG G
Sbjct: 476 KKGFRTRQRHVLMESTGPAGHCPHLVESVPCEDPMCYR--WLASEGICFPDHG-KCGLG- 531
Query: 635 RTRQRMLKSLAELGDCNEDLE----------QVEKCMLPECPIDCELTEWSQWSECNKSC 684
R+LK++ + D ED+ + + C +P C +DC L+EW++WS C++SC
Sbjct: 532 ---HRILKAVCQ-NDRGEDVSGSLCPVPPPPERKSCEIP-CRMDCVLSEWTEWSSCSQSC 586
Query: 685 GK----GHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRS 740
G R+R I GG PCP + ++ R+ + S +L W + S
Sbjct: 587 SNKNSDGKQTRSRTILALAGEGGKPCPPSQALQEHRL---CNDHSCMQLHWETSPWGPCS 643
Query: 741 EQLKEESEGEQFPGCRMRPWTAWS-ECTKLCGGGIQ-ERYMTVKKRFKSSQFTSCKDKKE 798
E + + W+ E T CG GIQ R VK C D
Sbjct: 644 EDTLVTA---------LNATIGWNGEAT--CGVGIQTRRVFCVKSHVGQVMTKRCPD--S 690
Query: 799 IRACNVHPC 807
R V PC
Sbjct: 691 TRPETVRPC 699
Score = 81.6 bits (200), Expect = 3e-15
Identities = 102/487 (20%), Positives = 163/487 (33%), Gaps = 122/487 (25%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDG 499
P C+ S + PWS CS K + + ++ L + CP+ + + C P
Sbjct: 146 PRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESRACDAPISCPLGE 205
Query: 500 STCTMSEWI-TWSPCSI----------------------------------------SCG 518
T S + WS C + +
Sbjct: 206 EEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTFKHQSYKAHHHSKSWAIE 265
Query: 519 MGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGM-- 576
+G ++R+ + ++ +L +++ TV P C ++W W CS TC
Sbjct: 266 IGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPKDCETSQWSSWSPCSKTCRSGS 325
Query: 577 ---GMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPW--SEWSDCSVT-- 629
G + R R +K G E + E C++ C W SEW +C V+
Sbjct: 326 LLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELLQQCPRYSWRTSEWKECQVSLL 385
Query: 630 --------------CGKGMRTRQ----RMLKSLAELGDCNEDLEQVEK------------ 659
CG G++TR+ + + + A L E VEK
Sbjct: 386 LEQQDPHWHVTGPVCGGGIQTREVYCAQSVPAAAAL-RAKEVSRPVEKALCVGPAPLPSQ 444
Query: 660 -CMLPECPIDCELTEWSQWSEC-NKSC-----GKGHVIRTRMIQMEPQFGGAPCPETVQR 712
C +P C DC ++ WS W C +++C KG R R + ME CP V+
Sbjct: 445 LCNIP-CSTDCIVSSWSAWGLCIHENCHDPQGKKGFRTRQRHVLMESTGPAGHCPHLVES 503
Query: 713 KKCRIRKCLRNPSIQKLRWREARE----SRRSEQLKEESEGEQFPG-------------- 754
C C R + + + + + + R + + + GE G
Sbjct: 504 VPCEDPMCYRWLASEGICFPDHGKCGLGHRILKAVCQNDRGEDVSGSLCPVPPPPERKSC 563
Query: 755 -------CRMRPWTAWSECTKLCGG----GIQERYMTVKKRFKSSQFTSCKDK---KEIR 800
C + WT WS C++ C G Q R T+ C +E R
Sbjct: 564 EIPCRMDCVLSEWTEWSSCSQSCSNKNSDGKQTRSRTI-LALAGEGGKPCPPSQALQEHR 622
Query: 801 ACNVHPC 807
CN H C
Sbjct: 623 LCNDHSC 629
Score = 60.1 bits (144), Expect = 8e-09
Identities = 51/183 (27%), Positives = 72/183 (39%), Gaps = 35/183 (19%)
Query: 565 GEWDECSATCGMGMKKRHRMIKMNPADG-----SMC-KAETSQAEKCMMPECHTIPCLLS 618
G W C+ CG G + R + DG S C ++ E+ C L
Sbjct: 16 GPWGRCTGDCGPG-GVQSRAVWCFHVDGWTSHLSNCGESNRPPKERSCFRVCDWHSDLFQ 74
Query: 619 PW--SEWSDC----------------SVTCGKGMRTRQ-RMLKSLAELGDCNEDLEQV-- 657
W S+W C VT G++ R R ++ L NE E
Sbjct: 75 -WEVSDWHHCVLVPYARGEVKPRTAECVTAQHGLQHRMVRCIQKLNRTVVANEICEHFAL 133
Query: 658 -----EKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQR 712
+ C++P CP DC ++E+ WS C+K CGK RTR + P FGG CP +
Sbjct: 134 QPPTEQACLIP-CPRDCVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTES 192
Query: 713 KKC 715
+ C
Sbjct: 193 RAC 195
Score = 60.1 bits (144), Expect = 8e-09
Identities = 68/261 (26%), Positives = 99/261 (37%), Gaps = 80/261 (30%)
Query: 487 QPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETE 546
Q C+ P D C +SE++ WS CS CG ++ R R V P G + E+
Sbjct: 139 QACLIPCPRD-----CVVSEFLPWSNCSKGCGKKLQHRTRAVIAPPLFGGLQCPNLTESR 193
Query: 547 KCTVNEECSPSSCLMTE--------WGEWDEC---------------------------- 570
C +P SC + E G W +C
Sbjct: 194 ACD-----APISCPLGEEEYTFSLKVGPWSKCRLPHLKEINPSGRTVLDFNSDSNERVTF 248
Query: 571 ----------SATCGMGMKKRHRMIKMNPADG-----SMCKAET--SQAEKCMMPECHTI 613
S + + + + R + +DG S+C ++ + C+MP+
Sbjct: 249 KHQSYKAHHHSKSWAIEIGYQTRQVSCTRSDGQNAMLSLCLQDSFPLTVQSCIMPK---- 304
Query: 614 PCLLSPWSEWSDCSVTCGK-----GMRTRQRMLKSLAELG--DCNEDLEQ----VEKCML 662
C S WS WS CS TC G R+R R +K +A G +C E LE+ VE +L
Sbjct: 305 DCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIVEGELL 364
Query: 663 PECPIDCELTEWSQWSECNKS 683
+CP T S+W EC S
Sbjct: 365 QQCPRYSWRT--SEWKECQVS 383
>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
sapiens]
Length = 1657
Score = 129 bits (325), Expect = 8e-30
Identities = 118/460 (25%), Positives = 183/460 (39%), Gaps = 110/460 (23%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQ-LDLSVPCP--------DTQDFQPCM 490
P C S WS WS CS S C G ++R + L+ + + PCP + PC
Sbjct: 1033 PSDCKLSEWSNWSRCSKS-CGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCH 1091
Query: 491 GPGCSDEDGSTCTMSEWIT--WSPCSIS-------CGMGMRSRERYVKQFPEDGSVCTLP 541
S C W+T WS C ++ CG G+++R+ Q DG P
Sbjct: 1092 ---------SDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADG-----P 1137
Query: 542 TEETEKCTVNEE--------CS---PSSCLMTEWGEWDECSATCGMG-MKKRHRMIKMNP 589
+E E + E C P C+++EWG W +C C ++R P
Sbjct: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQP 1197
Query: 590 ADGSMCKAETSQAEKCMMPE-CHTIPCLLSPWSEWSDCSVT----CGKGMRTRQ----RM 640
AD + E C + + C+ ++ +WS C ++ CG G++TR R
Sbjct: 1198 ADEGRSCPNAVEKEPCNLNKNCYHYDYNVT---DWSTCQLSEKAVCGNGIKTRMLDCVRS 1254
Query: 641 LKSLAELGDCN----EDLEQVEKCMLPECPIDCELTEWSQWSECNKSCG-KGHVIRTRMI 695
+L C E Q+ + ECP++C+L++WS WSEC+++CG G +IR R +
Sbjct: 1255 DGKSVDLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTV 1314
Query: 696 QMEPQFGGAPCPETV-QRKKCRIRKCLR------NP-SIQKLRWREARESR--------- 738
Q G PCP + Q K C ++ C R +P +Q+ + E +R
Sbjct: 1315 TQPFQGDGRPCPSLMDQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDG 1374
Query: 739 -----------------------RSEQLKEESEGEQFPG-CRMRPWTAWSECTKLC---- 770
+ EES + PG C ++ W++WS C C
Sbjct: 1375 SADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGE 1434
Query: 771 ---GGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
GGIQ R V + +Q + E ++C C
Sbjct: 1435 DLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQC 1474
Score = 112 bits (279), Expect = 2e-24
Identities = 116/461 (25%), Positives = 170/461 (36%), Gaps = 109/461 (23%)
Query: 336 CTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHP-QSPFYD--- 391
C+K CG SGV S P RP LDH Q+ Y+
Sbjct: 1047 CSKSCG-----------------SGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVP 1089
Query: 392 -----------PEGGSITQVARVVIERIARKGEQCNIV----------PDNVDDIVADLA 430
E SI +V V + +G Q V ++V+D + D
Sbjct: 1090 CHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCD-- 1147
Query: 431 PEEKDEDDT------PETCIYSNWSPWSACSSSTCDKGKRMRQR-MLKAQLDLSVPCPDT 483
PEE PE C+ S W PW+ C R R ++ D CP+
Sbjct: 1148 PEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSCPNA 1207
Query: 484 QDFQPC-MGPGCSDEDGSTCTMSEWITWSPCSIS----CGMGMRSRERYVKQFPEDGSVC 538
+ +PC + C D + WS C +S CG G+++R + DG
Sbjct: 1208 VEKEPCNLNKNCYHYDYNVTD------WSTCQLSEKAVCGNGIKTR--MLDCVRSDGKSV 1259
Query: 539 TLPTEET----EKCTVNEECS---PSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNP-- 589
L E + +N C P +C +++W W ECS TCG+ K R P
Sbjct: 1260 DLKYCEALGLEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQ 1319
Query: 590 ADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVT---CGKGMRTR--------- 637
DG C + Q++ C + PC + +WS C V CG+G RTR
Sbjct: 1320 GDGRPCPSLMDQSKPCPVK-----PCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDG 1374
Query: 638 ----------QRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKG 687
+ + + D N+++ E C P CP DC L +WS WS C +C G
Sbjct: 1375 SADDFSKVVDEEFCADIELIIDGNKNMVLEESCSQP-CPGDCYLKDWSSWSLCQLTCVNG 1433
Query: 688 H-------VIRTRMIQMEPQFGGAPCPE-TVQRKKCRIRKC 720
+R+R + ++ CPE ++ K C +C
Sbjct: 1434 EDLGFGGIQVRSRPVIIQELENQHLCPEQMLETKSCYDGQC 1474
Score = 102 bits (255), Expect = 1e-21
Identities = 102/499 (20%), Positives = 173/499 (34%), Gaps = 145/499 (29%)
Query: 426 VADLAPEEKDEDDTPET-----------CIYSNWSPWSACSSSTCDKGKRMRQRMLKAQL 474
V + P++ E PET CI + +S W++C SS C +G ++ + ++
Sbjct: 744 VGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDWTSCPSS-CKEGDSSIRKQSRHRV 802
Query: 475 DLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWIT--WSPCSI--------------SCG 518
+ +P +D + + E C W T W C + CG
Sbjct: 803 IIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCG 862
Query: 519 MGMRSRE-----------------RYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLM 561
G ++R +Y P C +P ++ C +
Sbjct: 863 PGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQD-------------DCQL 909
Query: 562 TEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCM------MPECHTIPC 615
T W ++ C+ CG ++ ++ ++ + EKC + E PC
Sbjct: 910 TSWSKFSSCNGDCGAVRTRKRTLV-----------GKSKKKEKCKNSHLYPLIETQYCPC 958
Query: 616 ---LLSPWSEWSDCSVT------------------CGKGMRTRQRMLKS----LAELGDC 650
P WSDC + CG+G R + L E C
Sbjct: 959 DKYNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRC 1018
Query: 651 NEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPE-- 708
N E C++P CP DC+L+EWS WS C+KSCG G +R++ ++ +P GG PCP+
Sbjct: 1019 NSHGYIEEACIIP-CPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLD 1077
Query: 709 -----------------------TVQRKKCRI------RKCLRNPSIQKLRWREARESRR 739
T C++ C +K+R +
Sbjct: 1078 HVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGP 1137
Query: 740 SEQLKEE-SEGEQFP------------GCRMRPWTAWSECTKLCGGGIQERYMTVKKRFK 786
SE +++ + E+ P C + W W++C C + R
Sbjct: 1138 SEHVEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQP 1197
Query: 787 SSQFTSCKDKKEIRACNVH 805
+ + SC + E CN++
Sbjct: 1198 ADEGRSCPNAVEKEPCNLN 1216
Score = 97.4 bits (241), Expect = 5e-20
Identities = 95/404 (23%), Positives = 151/404 (37%), Gaps = 97/404 (24%)
Query: 440 PETCIYSNWSPWSACSSSTCD-----KGKRMRQRMLKAQ----LDLSVPCPDTQDFQPCM 490
P C S WS W C+ C+ KG ++R+R + + ++ CP + PC
Sbjct: 510 PTECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCE 569
Query: 491 GPGCSD-----------EDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCT 539
P C D ++G C + C S G E +Q D ++
Sbjct: 570 EPACYDWKAVRLGNCEPDNGKECGPGTQVQEVVCINSDG------EEVDRQLCRD-AIFP 622
Query: 540 LPTEETEKCTVNEECSPSSCLMTEWGEWDECSATC------GMGMKKRHRMIKMNPADGS 593
+P C P C+++ W W CS TC G ++ R + G
Sbjct: 623 IPVACDAPC-------PKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGI 675
Query: 594 MCKAETSQAEKCMMPECHTIPCLLSPW--SEWSDC-----------------SVTCGKGM 634
C ++ E + C+ PC + W W C +C GM
Sbjct: 676 RCPNSSALQE---VRSCNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGM 732
Query: 635 RTRQRML--KSLAELG--DCNEDL--EQVEKCMLPECPIDCELTEWSQWSECNKSCGKG- 687
+TR+ + ++ ++G C E L E V C+LP C DC +T +S W+ C SC +G
Sbjct: 733 QTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLP-CKKDCIVTPYSDWTSCPSSCKEGD 791
Query: 688 ----HVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQL 743
R R+I P GG C + + +K C + Q RW+ + R
Sbjct: 792 SSIRKQSRHRVIIQLPANGGRDCTDPLYEEKA----CEAPQACQSYRWKTHKWRR----- 842
Query: 744 KEESEGEQFPGCRMRPWTAWSE---CTKLCGGGIQERYMTVKKR 784
C++ PW+ + + CG G Q R +T +K+
Sbjct: 843 -----------CQLVPWSVQQDSPGAQEGCGPGRQARAITCRKQ 875
Score = 96.7 bits (239), Expect = 8e-20
Identities = 109/448 (24%), Positives = 175/448 (39%), Gaps = 117/448 (26%)
Query: 440 PETCIYSNWSPWSACS---SSTCDKGKRMRQRMLKAQL--DLSVPCPDTQDFQ------- 487
P+ C+ S WS WS+CS S +GK++R R + A + + CP++ Q
Sbjct: 632 PKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNE 691
Query: 488 -PC------MGP-GCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYV----------K 529
PC GP G ED S + + TW+ SC +GM++R+ K
Sbjct: 692 HPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNG-EASCSVGMQTRKVICVRVNVGQVGPK 750
Query: 530 QFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMG-----MKKRHRM 584
+ PE +L E C + C C++T + +W C ++C G + RHR+
Sbjct: 751 KCPE-----SLRPETVRPCLL--PCK-KDCIVTPYSDWTSCPSSCKEGDSSIRKQSRHRV 802
Query: 585 IKMNPADGSM-CKAETSQAEKCMMPE-CHTI--------PCLLSPWSEWSD---CSVTCG 631
I PA+G C + + C P+ C + C L PWS D CG
Sbjct: 803 IIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCG 862
Query: 632 KGMRTR----QRMLKSLAELGDCNEDLEQV----EKCMLPECPIDCELTEWSQWSECNKS 683
G + R ++ A + +C + V + C +P C DC+LT WS++S CN
Sbjct: 863 PGRQARAITCRKQDGGQAGIHECLQYAGPVPALTQACQIP-CQDDCQLTSWSKFSSCNGD 921
Query: 684 CGKGHVIRTRM---------------IQMEPQFGGAPCP--------------------- 707
CG +RTR + P CP
Sbjct: 922 CG---AVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDKYNAQPVGNWSDCILPEGK 978
Query: 708 -ETVQRKKCR--IRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGC--------R 756
E + K + I++C + Q + + + R E + S G C +
Sbjct: 979 VEVLLGMKVQGDIKECGQGYRYQAMACYD-QNGRLVETSRCNSHGYIEEACIIPCPSDCK 1037
Query: 757 MRPWTAWSECTKLCGGGIQERYMTVKKR 784
+ W+ WS C+K CG G++ R ++++
Sbjct: 1038 LSEWSNWSRCSKSCGSGVKVRSKWLREK 1065
Score = 92.0 bits (227), Expect = 2e-18
Identities = 85/348 (24%), Positives = 130/348 (37%), Gaps = 92/348 (26%)
Query: 546 EKCTVNEECSPSSCLMTEWGEWDECSATCG-----MGMKKRHRMIKMNPADGSMCKAETS 600
+ C + +EC S EW EW CS TC G + R R I+ P E
Sbjct: 353 QSCVITKECQVS-----EWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFE 407
Query: 601 QAEKCMMPECHTIPCLLSPW--SEWSDCSVT----------------CGKGMRTRQ---- 638
+ E C+ +PC W +EW++C V CG G++TR+
Sbjct: 408 EKEPCLSQGDGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCV 467
Query: 639 ----RMLKSLA-----------ELGDCNEDLEQVEK-CMLPECPIDCELTEWSQWSECN- 681
+L L+ +L C + + C +P CP +CE++ WS W C
Sbjct: 468 QANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIP-CPTECEVSPWSAWGPCTY 526
Query: 682 KSCG-----KGHVIRTRMIQMEPQFGGAP---CPETVQRKKCRIRKCLRNPSIQ--KLRW 731
++C KG +R R I EP G CP ++ C C +++
Sbjct: 527 ENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEP 586
Query: 732 REARESRRSEQLKE----ESEGEQ----------FP-----------GCRMRPWTAWSEC 766
+E Q++E S+GE+ FP C + W+ WS C
Sbjct: 587 DNGKECGPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSC 646
Query: 767 TKLCGG----GIQERYMTVKKRFKSSQFTSCKDK---KEIRACNVHPC 807
+ C G G Q R ++ C + +E+R+CN HPC
Sbjct: 647 SHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC 694
Score = 88.6 bits (218), Expect = 2e-17
Identities = 88/343 (25%), Positives = 133/343 (38%), Gaps = 71/343 (20%)
Query: 443 CIYSNWSPWSACSSSTCDK----GKRMRQRMLKA-QLDLSVPCPDTQDFQPCMGPGCSDE 497
C S WS WS CS + D G R+R R ++ + CP+ ++ +PC+ G
Sbjct: 361 CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQG---- 416
Query: 498 DGST-CTMSEWIT--WSPCSIS----------------CGMGMRSRERYVKQF------- 531
DG C W T W+ C + CG G+++RE Y Q
Sbjct: 417 DGVVPCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQ 476
Query: 532 -----------PEDGSVCTLPTEETEK-CTVNEECSPSSCLMTEWGEWDECS-ATCG--- 575
P D +CT P T + C + P+ C ++ W W C+ C
Sbjct: 477 LSTHKNKEASKPMDLKLCTGPIPNTTQLCHIP---CPTECEVSPWSAWGPCTYENCNDQQ 533
Query: 576 --MGMKKRHRMIKMNPADGSMCKAETS---QAEKCMMPECHTIPCLLSPWSEWSDCSVTC 630
G K R R I P GS +A C P C+ + E D C
Sbjct: 534 GKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCE-PDNGKEC 592
Query: 631 GKGMRTRQRM-LKSLAELGD---CNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCG- 685
G G + ++ + + S E D C + + + CP DC L+ WS WS C+ +C
Sbjct: 593 GPGTQVQEVVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSG 652
Query: 686 ---KGHVIRTR-MIQMEPQFGGAPCPETVQRKKCRIRKCLRNP 724
+G IR R ++ + GG CP + ++ +R C +P
Sbjct: 653 KTTEGKQIRARSILAYAGEEGGIRCPNSSALQE--VRSCNEHP 693
Score = 81.3 bits (199), Expect = 3e-15
Identities = 94/411 (22%), Positives = 153/411 (37%), Gaps = 97/411 (23%)
Query: 450 PWSACSSST---------CDKGKRMRQ--RMLKAQLDLSVPCPDTQ----DFQPCMGPGC 494
PW+ C C KG+ Q + Q D +P D + +P + C
Sbjct: 128 PWNQCQPVISKSLEKPLECIKGEEGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQAC 187
Query: 495 SDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPE-DGSVCTLPTEETEKCTVNEE 553
C +SE+ WS CS +CG G++ R R+V P+ GS C TE +
Sbjct: 188 LIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTE-------FQV 240
Query: 554 CSPSSCLMTEW------GEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMM 607
C S C E G W CS +++ R K + K + ++
Sbjct: 241 CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELI 300
Query: 608 PECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRM----LKSLAELGDCNEDLEQV--EKCM 661
+ +++ D + G +TR+ M A+L C ++ + + C+
Sbjct: 301 KKKRNRNRQNRQENKYWDIQI----GYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCV 356
Query: 662 LPECPIDCELTEWSQWSECNKSC-----GKGHVIRTRMIQMEPQFGGAPCPETVQRKKCR 716
+ + +C+++EWS+WS C+K+C G +RTR I+ P CPE +++ C
Sbjct: 357 ITK---ECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCL 413
Query: 717 IRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPW--TAWSEC-------- 766
S+G+ C W T W+EC
Sbjct: 414 ------------------------------SQGDGVVPCATYGWRTTEWTECRVDPLLSQ 443
Query: 767 --------TKLCGGGIQER--YMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
T LCGGGIQ R Y SQ ++ K+K+ + ++ C
Sbjct: 444 QDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLC 494
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/213 (24%), Positives = 81/213 (38%), Gaps = 40/213 (18%)
Query: 438 DTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLD-LSVPCPDTQD-FQPCMGPGCS 495
+ P C S+WSPWS CS + GK +R+R + PCP D +PC
Sbjct: 1282 ECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSLMDQSKPC------ 1335
Query: 496 DEDGSTCTMSEWITWSPCSI---SCGMGMRSRERYVKQFPEDGSV--------------C 538
C ++ WSPC + CG G R+R + DGS
Sbjct: 1336 --PVKPCYRWQYGQWSPCQVQEAQCGEGTRTRN--ISCVVSDGSADDFSKVVDEEFCADI 1391
Query: 539 TLPTEETEKCTVNEECS---PSSCLMTEWGEWDECSATCGM-------GMKKRHRMIKMN 588
L + + + E CS P C + +W W C TC G++ R R + +
Sbjct: 1392 ELIIDGNKNMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGEDLGFGGIQVRSRPVIIQ 1451
Query: 589 PADGS-MCKAETSQAEKCMMPECHTIPCLLSPW 620
+ +C + + + C +C+ + S W
Sbjct: 1452 ELENQHLCPEQMLETKSCYDGQCYEYKWMASAW 1484
Score = 67.8 bits (164), Expect = 4e-11
Identities = 85/356 (23%), Positives = 138/356 (38%), Gaps = 52/356 (14%)
Query: 441 ETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDL-SVPCPDTQDFQPCMGPGCSDEDG 499
+ CI S +S WS C S TC G + R R + A CP+ +FQ C C E+
Sbjct: 193 QDCIVSEFSAWSEC-SKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQVCQSSPCEAEE- 250
Query: 500 STCTMSEWI-TWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSS 558
S + WS CS+ +R R K + + + + ++ + +
Sbjct: 251 --LRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNR 308
Query: 559 CLMTEWGEWDECSATCGMGMKKRHRMI---KMNPADGSMCKAE--TSQAEKCMMPECHTI 613
E WD +G + R M AD S C+ E + C++ T
Sbjct: 309 QNRQENKYWD-----IQIGYQTREVMCINKTGKAADLSFCQQEKLPMTFQSCVI----TK 359
Query: 614 PCLLSPWSEWSDCSVTC-------GKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLP-EC 665
C +S WSEWS CS TC G +RTR + +C E E+ E C+ +
Sbjct: 360 ECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPE-FEEKEPCLSQGDG 418
Query: 666 PIDCELTEW--SQWSECNKSCGKGHVIRTRMIQMEPQFGG--APCPETVQRKKCRIRKCL 721
+ C W ++W+EC + + Q + + G A C +Q ++ +
Sbjct: 419 VVPCATYGWRTTEWTECR--------VDPLLSQQDKRRGNQTALCGGGIQTREVYCVQAN 470
Query: 722 RNPSIQKLRWREARESRRSEQLK-------EESEGEQFP---GCRMRPWTAWSECT 767
N + +L + +E+ + LK ++ P C + PW+AW CT
Sbjct: 471 EN-LLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCPTECEVSPWSAWGPCT 525
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 128 bits (322), Expect = 2e-29
Identities = 94/318 (29%), Positives = 124/318 (38%), Gaps = 36/318 (11%)
Query: 427 ADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSV-----PCP 481
+DL P +S WS W C+ S C +G + R R + SV PC
Sbjct: 4571 SDLEMRNCQNKPCPVDGSWSEWSLWEECTRS-CGRGNQTRTRTCN---NPSVQHGGRPCE 4626
Query: 482 DTQ------DFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPE-- 533
+ +PC G S W W CS SCG G ++R R P
Sbjct: 4627 GNAVEIIMCNIRPCPVHGA---------WSAWQPWGTCSESCGKGTQTRARLCNNPPPAF 4677
Query: 534 DGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIK--MNPAD 591
GS C ET+ NE P W W CS +CG G ++R R +
Sbjct: 4678 GGSYCD--GAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYG 4735
Query: 592 GSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGD-- 649
G C+ Q++ C C T SPWS W CS TC G R R +
Sbjct: 4736 GRKCEGSDVQSDFCNSDPCPTHGNW-SPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGR 4794
Query: 650 -CNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQME-PQFGGAPCP 707
C Q+++C CP+D W WS+C+ SCG G R R+ P GG PCP
Sbjct: 4795 ACGGPDSQIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCP 4854
Query: 708 -ETVQRKKCRIRKCLRNP 724
+T Q +C ++ C P
Sbjct: 4855 GDTTQVTRCNVQACPGGP 4872
Score = 128 bits (321), Expect = 2e-29
Identities = 105/377 (27%), Positives = 144/377 (38%), Gaps = 54/377 (14%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLS--VPCPDTQ-DFQPCMGPGCSDEDGST 501
+S WS W AC S TC KG + R R+ L + PC + + + C C DGS
Sbjct: 4532 FSQWSAWRAC-SVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPC-PVDGS- 4588
Query: 502 CTMSEWITWSPCSISCGMGMRSRERYVK--QFPEDGSVCTLPTEETEKCTVNEECSPSSC 559
SEW W C+ SCG G ++R R G C E C + P
Sbjct: 4589 --WSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRP--CPVHG 4644
Query: 560 LMTEWGEWDECSATCGMGMKKRHRMIKMNPA--DGSMCKAETSQAEKCMMPECHTIPCLL 617
+ W W CS +CG G + R R+ P GS C +Q + C C I
Sbjct: 4645 AWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNC-PIHGKW 4703
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKS-LAELG--DCNEDLEQVEKCMLPECPIDCELTEW 674
+ W+ WS CSV+CG G R R R + + G C Q + C CP + W
Sbjct: 4704 ATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHGNWSPW 4763
Query: 675 SQWSECNKSCGKGHVIRTRMI-QMEPQFGGAPC--PETVQRKKCRIRKCLRNPSIQKLRW 731
S W C+++C G + R R P GG C P++ Q ++C C + S W
Sbjct: 4764 SGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDS-QIQRCNTDMCPVDGS-----W 4817
Query: 732 REARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFT 791
W +WS+C+ CGGG + R
Sbjct: 4818 GS--------------------------WHSWSQCSASCGGGEKTRKRLCDHPVPVKGGR 4851
Query: 792 SCK-DKKEIRACNVHPC 807
C D ++ CNV C
Sbjct: 4852 PCPGDTTQVTRCNVQAC 4868
Score = 68.2 bits (165), Expect = 3e-11
Identities = 59/212 (27%), Positives = 77/212 (36%), Gaps = 29/212 (13%)
Query: 415 CNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWS---PWSACSSSTCDKGKRMRQRMLK 471
CN P D A + + I+ W+ WSACS S C G R R R
Sbjct: 4670 CNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVS-CGGGARQRTR--- 4725
Query: 472 AQLDLSVPCPDTQDFQPCMGPGCSDEDGSTC---------TMSEWITWSPCSISCGMGMR 522
S P P + C G SD C S W W CS +C G
Sbjct: 4726 ---GCSDPVPQ-YGGRKCEG---SDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQM 4778
Query: 523 SRERYVKQFP--EDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKK 580
R R P G C P + ++C N + P W W +CSA+CG G K
Sbjct: 4779 RRYRTCDNPPPSNGGRACGGPDSQIQRC--NTDMCPVDGSWGSWHSWSQCSASCGGGEKT 4836
Query: 581 RHRMI--KMNPADGSMCKAETSQAEKCMMPEC 610
R R+ + G C +T+Q +C + C
Sbjct: 4837 RKRLCDHPVPVKGGRPCPGDTTQVTRCNVQAC 4868
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 120 bits (302), Expect = 4e-27
Identities = 67/220 (30%), Positives = 102/220 (46%), Gaps = 9/220 (4%)
Query: 506 EWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWG 565
EW WS CS +CG G ++R R+ + C+ P E C + C P EW
Sbjct: 359 EWSPWSVCSSTCGEGWQTRTRFCVS-SSYSTQCSGPLREQRLCNNSAVC-PVHGAWDEWS 416
Query: 566 EWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPEC--HTIPCLLSPWSEW 623
W CS+TCG G + R R + G+ C+ Q + C + C + + WS W
Sbjct: 417 PWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSW 476
Query: 624 SDCSVTCGKGMRTRQRMLKSLAELG-DCNEDLEQVEKCMLPECPIDCELTEWSQWSECNK 682
S CS +C +G + R R + G +C + C L +CP+D + W+ W C+
Sbjct: 477 SACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSV 536
Query: 683 SCGKGHVIRTRMIQMEPQFGGAPC--PETVQRKKCRIRKC 720
+CG G R R+ P FGGA C P+ + ++C ++C
Sbjct: 537 TCGAGSQRRERVCS-GPFFGGAACQGPQD-EYRQCGTQRC 574
Score = 107 bits (268), Expect = 3e-23
Identities = 68/237 (28%), Positives = 99/237 (41%), Gaps = 25/237 (10%)
Query: 448 WSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSD---EDGSTCTM 504
WSPWS C SSTC +G + R R C + C GP + + C +
Sbjct: 360 WSPWSVC-SSTCGEGWQTRTRF----------CVSSSYSTQCSGPLREQRLCNNSAVCPV 408
Query: 505 ----SEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCL 560
EW WS CS +CG G R R R + G+ C P ++T+ C N P +
Sbjct: 409 HGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFC--NIALCPGRAV 466
Query: 561 ---MTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLL 617
EW W CSA+C G ++R R G+ C+ + C + +C +
Sbjct: 467 DGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQC-PVDGKW 525
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAELG-DCNEDLEQVEKCMLPECPIDCELTE 673
W+ W CSVTCG G + R+R+ G C ++ +C CP E+ +
Sbjct: 526 QAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICD 582
Score = 104 bits (259), Expect = 4e-22
Identities = 90/343 (26%), Positives = 124/343 (36%), Gaps = 61/343 (17%)
Query: 499 GSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPE-DGSVCTLPTEETEKCTVNEECSPS 557
G+T W W C+ CG G+++R R P +G C EE +C E C P+
Sbjct: 259 GATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCN-REACGPA 317
Query: 558 SCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLL 617
+ R + D + + ++ P T
Sbjct: 318 G--------------------RTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAA 357
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKC-MLPECPIDCELTEWSQ 676
WS WS CS TCG+G +TR R S + C+ L + C CP+ EWS
Sbjct: 358 EEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSP 417
Query: 677 WSECNKSCGKGHVIRTRMIQMEPQFGGAPC--PETVQRKKCRIRKCLRNPSIQKLRWRE- 733
WS C+ +CG+G RTR + PQFGG PC PE Q K C I C W E
Sbjct: 418 WSLCSSTCGRGFRDRTRTCR-PPQFGGNPCEGPEK-QTKFCNIALC--PGRAVDGNWNEW 473
Query: 734 -------ARESRRSEQLKEESEGEQFPGC---------------------RMRPWTAWSE 765
A S+ +Q E G + G + + W +W
Sbjct: 474 SSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGS 533
Query: 766 CTKLCGGGIQERYMTVKKRFKSSQFTSCK-DKKEIRACNVHPC 807
C+ CG G Q R F +C+ + E R C C
Sbjct: 534 CSVTCGAGSQRRERVCSGPFFGG--AACQGPQDEYRQCGTQRC 574
Score = 81.6 bits (200), Expect = 3e-15
Identities = 53/170 (31%), Positives = 74/170 (43%), Gaps = 11/170 (6%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC----PDTQDFQPCMGPGCSDEDGS 500
+ WSPWS C SSTC +G R R R + PC T+ + PG + DG+
Sbjct: 412 WDEWSPWSLC-SSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRA-VDGN 469
Query: 501 TCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCL 560
+EW +WS CS SC G + R R G+ C ET C + ++C P
Sbjct: 470 ---WNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFL-QQC-PVDGK 524
Query: 561 MTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPEC 610
W W CS TCG G ++R R+ G+ C+ + +C C
Sbjct: 525 WQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRC 574
Score = 50.4 bits (119), Expect = 6e-06
Identities = 33/115 (28%), Positives = 50/115 (43%), Gaps = 13/115 (11%)
Query: 440 PETCIYSNWSPWSACS--SSTCDKGKRMRQRMLKAQLDLSVPCP----DTQDFQPCMGPG 493
P + NW+ WS+ S S++C +G++ R R C +T+D C
Sbjct: 462 PGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRD---CFLQQ 518
Query: 494 CSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKC 548
C DG W +W CS++CG G + RER G+ C P +E +C
Sbjct: 519 C-PVDGK---WQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQC 569
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 120 bits (302), Expect = 4e-27
Identities = 74/238 (31%), Positives = 102/238 (42%), Gaps = 13/238 (5%)
Query: 506 EWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWG 565
EW WS CS++CG G++ R R P G++C+ P ET C + C P + EWG
Sbjct: 314 EWSPWSVCSLTCGQGLQVRTRSCVSSPY-GTLCSGPLRETRPCNNSATC-PVHGVWEEWG 371
Query: 566 EWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSD 625
W CS +CG G + R R G C+ Q + C M C L W W
Sbjct: 372 SWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLE-WGPWGP 430
Query: 626 CSVTCGKGMRTRQRMLKSLAEL-GDCNEDLEQVEKCMLPECP-IDCELTEWSQWSECNKS 683
CS +C G + R R C L +C ECP D + W+ WS C+K+
Sbjct: 431 CSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKT 490
Query: 684 CGKGHVIRTRMIQMEPQFGGAPCPETVQR-KKCRIRKC------LRNPSIQKLRWREA 734
C G R RM Q G PC T + K C ++C R+ + + W++A
Sbjct: 491 CDTGWQRRFRMCQATGT-QGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKA 547
Score = 115 bits (288), Expect = 2e-25
Identities = 69/224 (30%), Positives = 99/224 (44%), Gaps = 15/224 (6%)
Query: 448 WSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTM--- 504
WSPWS CS TC +G ++R R + ++ ++ +PC + +TC +
Sbjct: 315 WSPWSVCSL-TCGQGLQVRTRSCVSSPYGTLCSGPLRETRPC-------NNSATCPVHGV 366
Query: 505 -SEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTE 563
EW +WS CS SCG G RSR R G C P +T+ C++ P E
Sbjct: 367 WEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSM--AACPVEGQWLE 424
Query: 564 WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEW 623
WG W CS +C G ++R R + + C + +C EC PW+ W
Sbjct: 425 WGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAW 484
Query: 624 SDCSVTCGKGMRTRQRMLKSLAELG-DCNEDLEQVEKCMLPECP 666
S CS TC G + R RM ++ G C E+V+ C CP
Sbjct: 485 SLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCP 528
Score = 96.7 bits (239), Expect = 8e-20
Identities = 62/247 (25%), Positives = 94/247 (38%), Gaps = 35/247 (14%)
Query: 563 EWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSE 622
EW W CS TCG G++ R R +P G++C + C + + W
Sbjct: 314 EWSPWSVCSLTCGQGLQVRTRSCVSSPY-GTLCSGPLRETRPCNNSATCPVHGVWEEWGS 372
Query: 623 WSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLE-QVEKCMLPECPIDCELTEWSQWSECN 681
WS CS +CG+G R+R R G E E Q + C + CP++ + EW W C+
Sbjct: 373 WSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCS 432
Query: 682 KSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSE 741
SC G R+R + ++C +C S +W
Sbjct: 433 TSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDS----KWG--------- 479
Query: 742 QLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDK-KEIR 800
PW AWS C+K C G Q R+ + +Q C+ +E++
Sbjct: 480 -----------------PWNAWSLCSKTCDTGWQRRFRMCQA--TGTQGYPCEGTGEEVK 520
Query: 801 ACNVHPC 807
C+ C
Sbjct: 521 PCSEKRC 527
Score = 82.4 bits (202), Expect = 2e-15
Identities = 49/176 (27%), Positives = 68/176 (38%), Gaps = 23/176 (13%)
Query: 444 IYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCT 503
++ W WS CS S C +G R R R P + C GP + C+
Sbjct: 366 VWEEWGSWSLCSRS-CGRGSRSRMRTC---------VPPQHGGKACEGP---ELQTKLCS 412
Query: 504 MS---------EWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEEC 554
M+ EW W PCS SC G + R R + CT +T +C+ N EC
Sbjct: 413 MAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECS-NLEC 471
Query: 555 SPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPEC 610
+ W W CS TC G ++R RM + G C+ + + C C
Sbjct: 472 PATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRC 527
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 117 bits (293), Expect = 4e-26
Identities = 68/219 (31%), Positives = 96/219 (43%), Gaps = 7/219 (3%)
Query: 504 MSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTE 563
+ EW WS CS++CG G + R R G+ C+ P E+ C N P + E
Sbjct: 294 VEEWSQWSTCSVTCGQGSQVRTRTC--VSPYGTHCSGPLRESRVCN-NTALCPVHGVWEE 350
Query: 564 WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEW 623
W W CS TCG G + R R G C+ + + C + C + WS W
Sbjct: 351 WSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALC-PVDGQWQEWSSW 409
Query: 624 SDCSVTCGKGMRTRQRMLKSLAELG-DCNEDLEQVEKCMLPECPIDCELTEWSQWSECNK 682
S CSVTC G + R R + A G +C + +C PEC + + +W WS C+K
Sbjct: 410 SQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSK 469
Query: 683 SCGKGHVIRTRMIQMEPQFGGAPCPETVQR-KKCRIRKC 720
SC G R R Q G C T + ++C ++C
Sbjct: 470 SCDGGWERRIRTCQ-GAVITGQQCEGTGEEVRRCSEQRC 507
Score = 107 bits (268), Expect = 3e-23
Identities = 66/225 (29%), Positives = 91/225 (40%), Gaps = 9/225 (4%)
Query: 448 WSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEW 507
WS WS CS TC +G ++R R + P ++ + C G EW
Sbjct: 297 WSQWSTCSV-TCGQGSQVRTRTCVSPYGTHCSGP-LRESRVCNNTALCPVHG---VWEEW 351
Query: 508 ITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEW 567
WS CS +CG G R+R R G C P + C + P EW W
Sbjct: 352 SPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPCNI--ALCPVDGQWQEWSSW 409
Query: 568 DECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCS 627
+CS TC G ++R R GS C+ +++ +C PEC T + W WS CS
Sbjct: 410 SQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPEC-TANGQWNQWGHWSGCS 468
Query: 628 VTCGKGMRTRQRMLKSLAELG-DCNEDLEQVEKCMLPECPIDCEL 671
+C G R R + G C E+V +C CP E+
Sbjct: 469 KSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQRCPAPYEI 513
Score = 104 bits (260), Expect = 3e-22
Identities = 80/290 (27%), Positives = 113/290 (38%), Gaps = 39/290 (13%)
Query: 520 GMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMK 579
GM Q P +P E+ + + S + EW +W CS TCG G +
Sbjct: 255 GMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTGESG--VEEWSQWSTCSVTCGQGSQ 312
Query: 580 KRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQR 639
R R ++P G+ C ++ C + + WS WS CS TCG+G RTR R
Sbjct: 313 VRTRTC-VSPY-GTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTR 370
Query: 640 MLKSLAELGDCNEDLEQVEK-CMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQME 698
G E E K C + CP+D + EWS WS+C+ +C G R+R
Sbjct: 371 SCTPPQYGGRPCEGPETHHKPCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAA 430
Query: 699 PQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMR 758
GG+ C R P W E+RE E +
Sbjct: 431 AH-GGSEC---------------RGP------WAESRECYNPECTANG---------QWN 459
Query: 759 PWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDK-KEIRACNVHPC 807
W WS C+K C GG + R T + + Q C+ +E+R C+ C
Sbjct: 460 QWGHWSGCSKSCDGGWERRIRTCQGAVITGQ--QCEGTGEEVRRCSEQRC 507
Score = 91.7 bits (226), Expect = 3e-18
Identities = 54/169 (31%), Positives = 76/169 (44%), Gaps = 10/169 (5%)
Query: 444 IYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC--PDTQDFQPCMGPGCSDEDGST 501
++ WSPWS C S TC +G+R R R PC P+T +PC C DG
Sbjct: 347 VWEEWSPWSLC-SFTCGRGQRTRTRSCTPPQYGGRPCEGPETH-HKPCNIALC-PVDGQ- 402
Query: 502 CTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLM 561
EW +WS CS++C G + R R GS C P E+ +C N EC+ +
Sbjct: 403 --WQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESREC-YNPECTANG-QW 458
Query: 562 TEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPEC 610
+WG W CS +C G ++R R + G C+ + +C C
Sbjct: 459 NQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQRC 507
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 112 bits (280), Expect = 1e-24
Identities = 98/400 (24%), Positives = 150/400 (37%), Gaps = 90/400 (22%)
Query: 448 WSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPG-----CSDEDGSTC 502
WSPW+ C T G + + + + P P +Q C GPG CS G T
Sbjct: 546 WSPWTPC---THTDGSAVGSCLCRTR-SCDSPAPQCGGWQ-CEGPGMEIANCSRNGGWT- 599
Query: 503 TMSEWITWSPCSISCGMGMRSRERYVKQFP--EDGSVCTLPTEETEKCTVNEECSPSSCL 560
W +WSPCS +CG+G + R+R G VC E C + C P
Sbjct: 600 ---PWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLC-PPHMF 655
Query: 561 MTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPC----L 616
T WG W+ C+A CG G++ R R+ + P D + C E C+T PC
Sbjct: 656 WTGWGPWERCTAQCGGGIQARRRICENGP-DCAGCNVE--------YQSCNTNPCPELKK 706
Query: 617 LSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPID----CEL- 671
+PW+ W+ +++ G ++ A L D N ++ + C D C
Sbjct: 707 TTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGCSTD 766
Query: 672 ---------------------TEWSQWSECNKSCGKGHVIRTRMI-QMEPQFGGAPC-PE 708
+ W+ WS+C++ C +G R R+ EP++GG PC
Sbjct: 767 GLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGP 826
Query: 709 TVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTK 768
+++ ++C I C + C W+ W++C+
Sbjct: 827 SLEYQECNILPC---------------------------PVDGVWSC----WSPWTKCSA 855
Query: 769 LCGGGIQERYMTVKKRFKSSQFTSCKD-KKEIRACNVHPC 807
CGGG R + + C E CN PC
Sbjct: 856 TCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPC 895
Score = 90.1 bits (222), Expect = 7e-18
Identities = 76/297 (25%), Positives = 122/297 (41%), Gaps = 49/297 (16%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDE---DGST 501
++ W+ WS CS+ TC G ++RQR S P P + C+G + +
Sbjct: 598 WTPWTSWSPCST-TCGIGFQVRQR------SCSNPTP-RHGGRVCVGQNREERYCNEHLL 649
Query: 502 CT----MSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPS 557
C + W W C+ CG G+++R R E+G C E + C N P
Sbjct: 650 CPPHMFWTGWGPWERCTAQCGGGIQARRRIC----ENGPDCAGCNVEYQSCNTNP--CPE 703
Query: 558 SCLMTEWGEWDECSATCGMG-MKKRHRMI-KMNPADGSMCKAETSQAE------------ 603
T W W + + G ++R R K AD ++ + + E
Sbjct: 704 LKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSGC 763
Query: 604 ----------KCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLA-ELGD--C 650
+ HT+ S W+ WS CS C +G+R R+R+ + + G C
Sbjct: 764 STDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPC 823
Query: 651 NEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMI-QMEPQFGGAPC 706
+ ++C + CP+D + WS W++C+ +CG GH +RTR P +GG C
Sbjct: 824 LGPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDIC 880
Score = 80.9 bits (198), Expect = 4e-15
Identities = 81/308 (26%), Positives = 120/308 (38%), Gaps = 50/308 (16%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDG 499
P ++ W PW C++ C G + R+R+ + D + C ++Q C C +
Sbjct: 651 PPHMFWTGWGPWERCTAQ-CGGGIQARRRICENGPDCA-GC--NVEYQSCNTNPCPELKK 706
Query: 500 STCTMSEWITWSPCSISCGMG-MRSRERYV-KQFPEDGSVCTLPTEETEKCTVNEE---- 553
+T W W+P +IS G R RY K D ++ + + E + +
Sbjct: 707 TT----PWTPWTPVNISDNGGHYEQRFRYTCKARLADPNLLEVGRQRIEMRYCSSDGTSG 762
Query: 554 CSPSSC-----------------LMTEWGEWDECSATCGMGMKKRHRMIKM-NPADGSM- 594
CS + W W +CS C G++ R R+ P G M
Sbjct: 763 CSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMP 822
Query: 595 CKAETSQAEKCMMPECHTIPC----LLSPWSEWSDCSVTCGKG--MRTRQRMLKSLAELG 648
C + + + EC+ +PC + S WS W+ CS TCG G MRTR + A G
Sbjct: 823 CLGPSLEYQ-----ECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGG 877
Query: 649 DCNEDLEQVEK-CMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCP 707
D L E C CP +EWS WSEC S G +R R + G
Sbjct: 878 DICLGLHTEEALCNTQPCPESW--SEWSDWSECEAS---GVQVRARQCILLFPMGSQCSG 932
Query: 708 ETVQRKKC 715
T + + C
Sbjct: 933 NTTESRPC 940
Score = 75.1 bits (183), Expect = 2e-13
Identities = 55/164 (33%), Positives = 77/164 (46%), Gaps = 17/164 (10%)
Query: 505 SEWITWSPCSISCGMGMRSRERYVKQFPED---GSVCTLPTEETEKCTVNEECSPSSCLM 561
S W +WS CS C G+R+R+R PE G C P+ E ++C + P +
Sbjct: 788 SAWTSWSQCSRDCSRGIRNRKRVCNN-PEPKYGGMPCLGPSLEYQECNILP--CPVDGVW 844
Query: 562 TEWGEWDECSATCGMGMKKRHRMIKMNPAD---GSMCKAETSQAEKCMMPECHTIPCLLS 618
+ W W +CSATCG G R R NPA G +C E+ + C+T PC S
Sbjct: 845 SCWSPWTKCSATCGGGHYMRTRSCS-NPAPAYGGDICLG--LHTEEAL---CNTQPCPES 898
Query: 619 PWSEWSDCSVTCGKGMRTRQRMLKSLAELG-DCNEDLEQVEKCM 661
WSEWSD S G++ R R L +G C+ + + C+
Sbjct: 899 -WSEWSDWSECEASGVQVRARQCILLFPMGSQCSGNTTESRPCV 941
Score = 64.3 bits (155), Expect = 4e-10
Identities = 49/170 (28%), Positives = 74/170 (43%), Gaps = 23/170 (13%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTC-- 502
+S W+ WS CS C +G R R+R+ P P PC+GP ++ +
Sbjct: 787 WSAWTSWSQCSRD-CSRGIRNRKRVCNN------PEPKYGGM-PCLGPSLEYQECNILPC 838
Query: 503 ----TMSEWITWSPCSISCGMG--MRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSP 556
S W W+ CS +CG G MR+R G +C TE+ N + P
Sbjct: 839 PVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICL--GLHTEEALCNTQPCP 896
Query: 557 SSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCM 606
S +EW +W EC A+ G++ R R + GS C T+++ C+
Sbjct: 897 ES--WSEWSDWSECEAS---GVQVRARQCILLFPMGSQCSGNTTESRPCV 941
Score = 47.8 bits (112), Expect = 4e-05
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 34/148 (22%)
Query: 413 EQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKA 472
++CNI+P VD + +S WSPW+ C S+TC G MR R
Sbjct: 831 QECNILPCPVDGV-------------------WSCWSPWTKC-SATCGGGHYMRTR---- 866
Query: 473 QLDLSVPCPDTQDFQPCMGPGCSDEDGST--C--TMSEWITWSPCSISCGMGMRSRERYV 528
S P P C+G + +T C + SEW WS C S G+ +R+R+ +
Sbjct: 867 --SCSNPAP-AYGGDICLGLHTEEALCNTQPCPESWSEWSDWSECEAS-GVQVRARQ-CI 921
Query: 529 KQFPEDGSVCTLPTEETEKCTVNEECSP 556
FP GS C+ T E+ C + P
Sbjct: 922 LLFPM-GSQCSGNTTESRPCVFDSNFIP 948
Score = 40.0 bits (92), Expect = 0.009
Identities = 40/158 (25%), Positives = 57/158 (36%), Gaps = 32/158 (20%)
Query: 661 MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFG----GAPCPET----VQR 712
++ +C E +QW + +C TR + ++ FG PC T V
Sbjct: 509 VMKKCTSLEESLSMTQWEQSISACP------TRNLTVDGHFGVWSPWTPCTHTDGSAVGS 562
Query: 713 KKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMR----PWTAWSECTK 768
CR R C +P+ Q W+ E G + C PWT+WS C+
Sbjct: 563 CLCRTRSC-DSPAPQCGGWQC------------EGPGMEIANCSRNGGWTPWTSWSPCST 609
Query: 769 LCGGGIQERYMTVKKRFKSSQFTSC-KDKKEIRACNVH 805
CG G Q R + C +E R CN H
Sbjct: 610 TCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEH 647
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 110 bits (275), Expect = 5e-24
Identities = 125/498 (25%), Positives = 180/498 (36%), Gaps = 141/498 (28%)
Query: 420 DNVDDIVADLAPEEKDEDDTPETCIYSNW--SPWSACSSSTCDKGKRMRQRMLKAQLDLS 477
+ VDD P+ + + C W S W+ CS S CD G + R+ +
Sbjct: 973 EKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKS-CDGGTQRRRAI-------- 1023
Query: 478 VPCPDTQDFQPCMGPGCSDEDGSTCTMSEWIT----------------WSPCSISCGMGM 521
C+ D S CT E +T WS C ++CG G
Sbjct: 1024 -----------CVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGH 1072
Query: 522 RSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKR 581
+ R+ + QF ED + ET K T + C C + G W +CS TCG G + R
Sbjct: 1073 KHRQVWC-QFGEDRLNDRMCDPET-KPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLR 1130
Query: 582 HRMIK------MNPADGSMCKAET--SQAEKCMMPECHTIPCL-----------LSPW-- 620
+K M+ D + C A T + + C +P CH P + W
Sbjct: 1131 --AVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRF 1188
Query: 621 SEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPI---DCELTEWSQW 677
W+ CS TCGKG R R + D N + C P+ +C +T QW
Sbjct: 1189 GSWTPCSATCGKGTRMRYVSCR------DENGSVADESACATLPRPVAKEECSVTPCGQW 1242
Query: 678 -----SECNKSCGKGHVIRTRMI-------------------QMEPQFGGAPCPETV--- 710
S C+ +CG+G R M + + +PCP+
Sbjct: 1243 KALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDS 1302
Query: 711 -------QRKKCRIRKC--LRNPSIQKLRWRE----------ARESRRSEQLKEESEGEQ 751
Q + R R R + +WR A S+R + ++ G
Sbjct: 1303 GLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYT 1362
Query: 752 FPGC--RMRP---------------WTAWSECTKLCGGGIQERYMTVKKRFKSSQF--TS 792
C R++P + W ECTKLCGGGI+ R + V +R +F S
Sbjct: 1363 ANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTR-LVVCQRSNGERFPDLS 1421
Query: 793 CK--DKKEIR-ACNVHPC 807
C+ DK R CN H C
Sbjct: 1422 CEILDKPPDREQCNTHAC 1439
Score = 102 bits (254), Expect = 1e-21
Identities = 94/398 (23%), Positives = 167/398 (41%), Gaps = 58/398 (14%)
Query: 437 DDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSD 496
+D P+ +++ PW ACS +G+R R+ + + D D P G ++
Sbjct: 873 EDKPQQFYWNSHGPWQACSKPC--QGERKRKLVCTRESDQLTVSDQRCDRLPQPGH-ITE 929
Query: 497 EDGSTCTMSEWI-TWSPCSISCGMGMRSRERYVKQFPE--------DGSVCTLPTEETEK 547
G+ C + + + S CS CG+G R+ + Y ++ D C+ + + +
Sbjct: 930 PCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNR 989
Query: 548 CTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMM 607
+ EC+ + W ECS +C G ++R R I +N + + ++ + EK +
Sbjct: 990 EKCSGECNTGGW---RYSAWTECSKSCDGGTQRR-RAICVNTRNDVLDDSKCTHQEKVTI 1045
Query: 608 PECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLK-SLAELGD--CNEDLE--QVEKCML 662
C PC +WS+C VTCGKG + RQ + L D C+ + + ++ C
Sbjct: 1046 QRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQ 1105
Query: 663 PECPIDCELTEW--SQWSECNKSCGKGH-------VIRTRMIQMEPQFGGAPCPETVQRK 713
PEC W W +C+ +CG+G+ +I T M ++ A T +
Sbjct: 1106 PEC------ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPT-DTQ 1158
Query: 714 KCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGG 773
C + C P+ A E+RRS ++ + +W+ C+ CG G
Sbjct: 1159 DCELPSCHPPPA--------APETRRSTYSAPRTQWR---------FGSWTPCSATCGKG 1201
Query: 774 IQERYMTVKKRFKS-SQFTSCKDKKEIRA---CNVHPC 807
+ RY++ + S + ++C A C+V PC
Sbjct: 1202 TRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPC 1239
Score = 101 bits (252), Expect = 2e-21
Identities = 110/447 (24%), Positives = 166/447 (37%), Gaps = 106/447 (23%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQ----DFQPC--MGPGCSDED 498
+ +W+P SA TC KG RMR V C D D C + + E+
Sbjct: 1188 FGSWTPCSA----TCGKGTRMRY----------VSCRDENGSVADESACATLPRPVAKEE 1233
Query: 499 GSTCTMSEW--ITWSPCSISCGMGMRSRE------------------RYVKQFPEDGSVC 538
S +W + WS CS++CG G +R+ Y+ + +D S+
Sbjct: 1234 CSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMS 1293
Query: 539 TLPTEETEKCTV-----NEECSPSSCLMT--------EW--GEWDECSATCGMGMKKRHR 583
P + NE+ P S + +W G W CS+TC G ++ R
Sbjct: 1294 PCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQR--R 1351
Query: 584 MIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTR------ 637
++ +G + + C + PC + W +C+ CG G+RTR
Sbjct: 1352 VVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQR 1411
Query: 638 ---QRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWS--QWSECNKSCGKGHVIRT 692
+R E+ D D EQ C CP D WS WS C+ SCG+GH R
Sbjct: 1412 SNGERFPDLSCEILDKPPDREQ---CNTHACPHD---AAWSTGPWSSCSVSCGRGHKQRN 1465
Query: 693 --RMIQMEPQFGGAPCPETVQ---RKKCRIRKC--------------------LRNPSIQ 727
M + C + +KCR +C R+ Q
Sbjct: 1466 VYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQ 1525
Query: 728 KLRWREARESRRSEQLKEESEGE-QFPGCRMRPWTA--WSECTKLCGGGIQERYMTV--- 781
+ ARE+ + + ESE + Q P C + W A W ECTK CG G + R +
Sbjct: 1526 IGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDD 1585
Query: 782 -KKRFKSSQFTSCKDKKEIRACNVHPC 807
K ++ K + +C++ PC
Sbjct: 1586 NKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 87.4 bits (215), Expect = 5e-17
Identities = 78/300 (26%), Positives = 115/300 (38%), Gaps = 64/300 (21%)
Query: 431 PEEKDEDDTPETCIYSNWS--PWSACSSSTCDKGKRMRQRMLKA------QLDLSVPCPD 482
P ++++ +T + WS PWS+CS S C +G + R A + D
Sbjct: 1428 PPDREQCNTHACPHDAAWSTGPWSSCSVS-CGRGHKQRNVYCMAKDGSHLESDYCKHLAK 1486
Query: 483 TQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSR----ERYVKQFPEDGSVC 538
+ C G C WS CS+SCG G++ R + + +
Sbjct: 1487 PHGHRKCRGGRCPKWKAGA--------WSQCSVSCGRGVQQRHVGCQIGTHKIARETECN 1538
Query: 539 TLPTEETEKCTVNEECSPSSCLMTEWG--EWDECSATCGMGMKKRHRMI---KMNPADGS 593
E+E+ +C C + W EW EC+ TCG G + R + N G+
Sbjct: 1539 PYTRPESER-----DCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGA 1593
Query: 594 MCKAETSQA--EKCMMPECHTIPCLLSPW--SEWSDCSVTCGKGMRTRQRMLKSLAELGD 649
C E C + C + W EWS+CSVTCGKG + R L S +E+
Sbjct: 1594 RCDVSKRPVDRESCSLQPCEYV------WITGEWSECSVTCGKGYKQR---LVSCSEIYT 1644
Query: 650 CNEDLE---------------QVEKCMLPECPIDCELTEW--SQWSECNKSCGKGHVIRT 692
E+ E V C L +CP+ W W C+ SCG G + R+
Sbjct: 1645 GKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSAT---WRVGNWGSCSVSCGVGVMQRS 1701
Score = 85.9 bits (211), Expect = 1e-16
Identities = 75/285 (26%), Positives = 117/285 (41%), Gaps = 49/285 (17%)
Query: 433 EKDEDDTPETCIYSNWSPWSACSSSTCDK--GKRMRQRMLKAQLDLSVPCPDTQ------ 484
E+ + D C W+ + C K G +R R++ Q PD
Sbjct: 1368 ERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDK 1427
Query: 485 --DFQPCMGPGCSDEDGSTCTMSEWIT--WSPCSISCGMGMRSRERYVKQFPEDGSVCTL 540
D + C C + + W T WS CS+SCG G + R Y +DGS
Sbjct: 1428 PPDREQCNTHACPHD-------AAWSTGPWSSCSVSCGRGHKQRNVYC--MAKDGSHLES 1478
Query: 541 P-TEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAET 599
+ K + +C C + G W +CS +CG G+++RH ++ G+ A
Sbjct: 1479 DYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQI----GTHKIARE 1534
Query: 600 SQAEKCMMPE----CHTIPCLLSPW--SEWSDCSVTCGKGMRTRQRMLKSLAELGDCNED 653
++ PE C C L W EW +C+ TCG+G R R+ + D N++
Sbjct: 1535 TECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCV------DDNKN 1588
Query: 654 LEQVEKCMLPECPID--------CELTEW--SQWSECNKSCGKGH 688
+C + + P+D CE W +WSEC+ +CGKG+
Sbjct: 1589 EVHGARCDVSKRPVDRESCSLQPCEYV-WITGEWSECSVTCGKGY 1632
Score = 61.2 bits (147), Expect = 4e-09
Identities = 65/244 (26%), Positives = 93/244 (38%), Gaps = 42/244 (17%)
Query: 451 WSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWIT- 509
WS CS S G+ ++QR + Q+ +T+ D G C + W
Sbjct: 1506 WSQCSVSC---GRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAE 1562
Query: 510 -WSPCSISCGMGMRSRERYVKQFPED---GSVCTLPTEETEKCTVNEECSPSSCLMTEW- 564
W C+ +CG G R R+ ++ G+ C + ++ E CS C W
Sbjct: 1563 EWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDR----ESCSLQPCEYV-WI 1617
Query: 565 -GEWDECSATCGMGMKKR---HRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLL--- 617
GEW ECS TCG G K+R I + T P H PC L
Sbjct: 1618 TGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVH--PCYLRDC 1675
Query: 618 ---SPW--SEWSDCSVTCGKGMRTRQRMLKSLAELGD----CNEDLEQVEK--------C 660
+ W W CSV+CG G+ QR ++ L C+ DL+ E+ C
Sbjct: 1676 PVSATWRVGNWGSCSVSCGVGV--MQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
Query: 661 MLPE 664
LP+
Sbjct: 1734 ELPQ 1737
Score = 32.0 bits (71), Expect = 2.4
Identities = 23/89 (25%), Positives = 33/89 (37%), Gaps = 17/89 (19%)
Query: 541 PTEETEKCTVNEECSPSSCLMTE---------WGEWDE---CSATCGMGMKKRHRMI-KM 587
P + +C + C C+ E WG W CS TCG G+K R +
Sbjct: 559 PWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
Query: 588 NPADGSMCKAETSQAEKCMMPECHTIPCL 616
P +G + + C+T PCL
Sbjct: 619 EPKNG----GKYCVGRRMKFKSCNTEPCL 643
Score = 31.6 bits (70), Expect = 3.1
Identities = 12/49 (24%), Positives = 24/49 (48%), Gaps = 1/49 (2%)
Query: 760 WTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKK-EIRACNVHPC 807
W+ + C++ CGGGI+ + + C ++ + ++CN PC
Sbjct: 594 WSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 642
Score = 30.8 bits (68), Expect = 5.2
Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 3/53 (5%)
Query: 590 ADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSD---CSVTCGKGMRTRQR 639
ADG+ C+ +P+ +P W WS CS TCG G++T R
Sbjct: 561 ADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIR 613
Score = 30.0 bits (66), Expect = 8.9
Identities = 17/53 (32%), Positives = 28/53 (52%), Gaps = 6/53 (11%)
Query: 674 WSQWSECNKSCGKGHVIRTRMIQM---EPQFGGAPC-PETVQRKKCRIRKCLR 722
WS + C+++CG G I+T + + EP+ GG C ++ K C CL+
Sbjct: 594 WSPFGTCSRTCGGG--IKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLK 644
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 109 bits (273), Expect = 9e-24
Identities = 69/196 (35%), Positives = 92/196 (46%), Gaps = 25/196 (12%)
Query: 550 VNEECSPSSCL--------MTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQ 601
V EC PS CL + W EW +CS TCG G ++R R + + C + Q
Sbjct: 366 VEGECCPS-CLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT---SNTCLGPSIQ 421
Query: 602 AEKCMMPECHTIPCL---LSPWSEWSDCSVTCGKGMRTRQRMLKS-LAELG--DCNEDLE 655
C + +C T S WS WS CSVTCG G TR R+ S + ++G +C
Sbjct: 422 TRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGR 481
Query: 656 QVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQM-EPQFGGAPCPETVQ--- 711
+ + C CPID + WS WS C +C G RTR+ EPQ+GG C VQ
Sbjct: 482 ETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQ 541
Query: 712 ---RKKCRIRKCLRNP 724
++ C + CL NP
Sbjct: 542 MCNKRSCPVDGCLSNP 557
Score = 91.3 bits (225), Expect = 3e-18
Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 27/229 (11%)
Query: 453 ACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMG-----PGCSDEDGSTCTMSEW 507
+C++ TC K K + + + CP P P C S W
Sbjct: 337 SCTTCTCKKFKTICHQ---------ITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPW 387
Query: 508 ITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSP---SSCLMTEW 564
W+ CS++CG G + R R + C P+ +T C++++ C + W
Sbjct: 388 AEWTQCSVTCGSGTQQRGR---SCDVTSNTCLGPSIQTRACSLSK-CDTRIRQDGGWSHW 443
Query: 565 GEWDECSATCGMGMKKRHRMIK--MNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSE 622
W CS TCG+G R R+ + G CK + + C C I SPWS
Sbjct: 444 SPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPC-PIDGRWSPWSP 502
Query: 623 WSDCSVTCGKGMRTRQRMLKS-LAELGD--CNEDLEQVEKCMLPECPID 668
WS C+VTC G+R R R+ S + G C D+++ + C CP+D
Sbjct: 503 WSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVD 551
Score = 85.5 bits (210), Expect = 2e-16
Identities = 59/196 (30%), Positives = 76/196 (38%), Gaps = 38/196 (19%)
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPI----DCELTE 673
SPW+EW+ CSVTCG G T+QR C Q C L +C D +
Sbjct: 385 SPWAEWTQCSVTCGSG--TQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSH 442
Query: 674 WSQWSECNKSCGKGHVIRTRMIQME-PQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWR 732
WS WS C+ +CG G++ R R+ PQ GG C + + K C P RW
Sbjct: 443 WSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKA----CQGAPCPIDGRWS 498
Query: 733 EARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTS 792
PW+ WS CT C GGI+ER +
Sbjct: 499 --------------------------PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKA 532
Query: 793 C-KDKKEIRACNVHPC 807
C D +E + CN C
Sbjct: 533 CVGDVQERQMCNKRSC 548
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/187 (26%), Positives = 74/187 (39%), Gaps = 9/187 (4%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTM 504
+S W+ W+ CS TC G + R R + + P Q + C C
Sbjct: 384 WSPWAEWTQCSV-TCGSGTQQRGRSCDVTSNTCLG-PSIQT-RACSLSKCDTRIRQDGGW 440
Query: 505 SEWITWSPCSISCGMGMRSRERYVKQ-FPE-DGSVCTLPTEETEKCTVNEECSPSSCLMT 562
S W WS CS++CG+G +R R P+ G C ET+ C C P +
Sbjct: 441 SHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQ-GAPC-PIDGRWS 498
Query: 563 EWGEWDECSATCGMGMKKRHRMIKMNPAD--GSMCKAETSQAEKCMMPECHTIPCLLSPW 620
W W C+ TC G+++R R+ G C + + + C C CL +P
Sbjct: 499 PWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC 558
Query: 621 SEWSDCS 627
+ CS
Sbjct: 559 FPGAQCS 565
Score = 56.6 bits (135), Expect = 9e-08
Identities = 42/137 (30%), Positives = 59/137 (43%), Gaps = 19/137 (13%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDE--DGSTC 502
+S+WSPWS+C S TC G R R+ + P P + C G G + G+ C
Sbjct: 440 WSHWSPWSSC-SVTCGVGNITRIRLCNS------PVPQ-MGGKNCKGSGRETKACQGAPC 491
Query: 503 TM----SEWITWSPCSISCGMGMRSRERYVKQFPE---DGSVCTLPTEETEKCTVNEECS 555
+ S W WS C+++C G+R R R V PE G C +E + C C
Sbjct: 492 PIDGRWSPWSPWSACTVTCAGGIRERTR-VCNSPEPQYGGKACVGDVQERQMCN-KRSCP 549
Query: 556 PSSCLMTEWGEWDECSA 572
CL +CS+
Sbjct: 550 VDGCLSNPCFPGAQCSS 566
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 103 bits (256), Expect = 8e-22
Identities = 99/404 (24%), Positives = 132/404 (32%), Gaps = 87/404 (21%)
Query: 448 WSPWSACSSSTCDKGK---RMRQRMLKAQLDLSVPC-------PDTQDFQPCMGPGCSDE 497
WS WS CS S D + R R R+ A + P P + C GPGC
Sbjct: 3886 WSSWSPCSRSCTDPARPAWRSRTRLCLANCTMGDPLQERPCNLPSCTELPVCPGPGCG-- 3943
Query: 498 DGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVC-TLPTEETEKCTVNEECSP 556
C+ + W W PCS SCG+G + R R + G C + T E+ N P
Sbjct: 3944 -AGNCSWTSWAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNILTAYQERRFCNLRACP 4002
Query: 557 SSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPAD--GSMCKAETSQAEKCMMPECHT-- 612
+ W W C +CG G R R P+ G+ C E QA C C
Sbjct: 4003 VPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGC 4062
Query: 613 ------------IPCLLSPWSEWSDCS--VTCGKGMRTRQRMLKS---LAELGDCN---- 651
P S E C C KG R + L+ +G C+
Sbjct: 4063 PAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDA 4122
Query: 652 ------EDLEQVEKCMLPEC--------------PIDCELTEWSQWSECNKSCGKGHVIR 691
+ + C C P C + WS WS C+ SCG R
Sbjct: 4123 QGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTHCAWSHWSAWSPCSHSCGP----R 4178
Query: 692 TRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQ 751
+ + G+ PE CR + P Q + RS L + +
Sbjct: 4179 GQQSRFRSSTSGSWAPE------CREEQSQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGE 4232
Query: 752 FPGCRMRP------------------WTAWSECTKLCGGGIQER 777
C P W++WS+C CGGG Q R
Sbjct: 4233 CQRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVR 4276
Score = 102 bits (255), Expect = 1e-21
Identities = 97/378 (25%), Positives = 143/378 (37%), Gaps = 57/378 (15%)
Query: 454 CSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPC 513
CS C+KG+ + C GC C S W +W+PC
Sbjct: 2695 CSQCVCEKGELL-----------------------CQPGGCP----LPCGWSAWSSWAPC 2727
Query: 514 SISCGMGMRSRERYVKQFPE--DGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECS 571
SCG G+R+R R P G+ C +E + C + C T W W CS
Sbjct: 2728 DRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGC--HTVCGTEVFGWTPWTSWSSCS 2785
Query: 572 ATC-----GMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDC 626
+C G G + R R+ +P D S C + +Q E C P C +P + W+ WS C
Sbjct: 2786 QSCLAPGGGPGWRSRSRLCP-SPGDSS-CPGDATQEEPCSPPVC-PVPSIWGLWAPWSTC 2842
Query: 627 SVTCGKGMRTRQRMLKSLAELGD--CNEDLEQVEKCMLPECPIDC-ELTEWSQWSECNKS 683
S C G++TR R SLA GD C Q C C C E + +C++
Sbjct: 2843 SAPCDGGIQTRGRSCSSLAP-GDTTCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQE 2901
Query: 684 CGK-GHVIRTRMIQMEPQFGGAP---CP--------ETVQRKKCRIRKCLRNPSIQKLRW 731
G + T+ +E AP CP + R +C + + + +
Sbjct: 2902 GGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLPRSQCPCQLHGQLYASGAMAR 2961
Query: 732 REARESRRSEQLKEESEGEQFP-GCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQF 790
++ + K E+ P C PWT WS C+ C GI+ R+ +
Sbjct: 2962 LDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGG 3021
Query: 791 TSCK-DKKEIRACNVHPC 807
C+ E C++ PC
Sbjct: 3022 AECQGPTMEAEFCSLRPC 3039
Score = 99.4 bits (246), Expect = 1e-20
Identities = 111/444 (25%), Positives = 158/444 (35%), Gaps = 109/444 (24%)
Query: 428 DLAPEEKD--EDDTPETCIYSNWSPWSACSSSTCDKGKR-MRQRMLKAQLDLSVPCP-DT 483
DL P+ +D ++D C+ + WS WS+CS S C G RQ +L+ L CP D
Sbjct: 2484 DLRPDCQDGSDEDGCVDCVLAPWSVWSSCSRS-CGLGLTFQRQELLRPPLP-GGSCPRDR 2541
Query: 484 QDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFP--EDGSVCTLP 541
Q C C + W W PCS+SCG G +SR+R P G+ C
Sbjct: 2542 FRSQSCFVQACP----VAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGA 2597
Query: 542 TEETEKCTVNEECS-------------------------PSSCLMTEWGEWDECSATCGM 576
++E C + + CS P SCL + CS C
Sbjct: 2598 SQERAPCGL-QPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANR--SCSGHCVE 2654
Query: 577 GMK-------KRHRMIKMNPAD----------------GSMCKAETSQAEKCMMPECHTI 613
G + R + ++ G+ + + E P +
Sbjct: 2655 GCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLGNCSQCVCEKGELLCQPGGCPL 2714
Query: 614 PCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAEL---GDCNEDLEQVEKCMLPECPIDCE 670
PC S WS W+ C +CG G+R R R + C D ++++ C
Sbjct: 2715 PCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFG 2774
Query: 671 LTEWSQWSECNKSC-----GKGHVIRTRMIQMEPQFGGAPCP-ETVQRKKCRIRKCLRNP 724
T W+ WS C++SC G G R+R+ P G + CP + Q + C C P
Sbjct: 2775 WTPWTSWSSCSQSCLAPGGGPGWRSRSRLC---PSPGDSSCPGDATQEEPCSPPVC-PVP 2830
Query: 725 SIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKR 784
SI L W WS C+ C GGIQ R +
Sbjct: 2831 SIWGL------------------------------WAPWSTCSAPCDGGIQTRGRSCSSL 2860
Query: 785 FKSSQFTSCK-DKKEIRACNVHPC 807
T+C + R CN PC
Sbjct: 2861 APGD--TTCPGPHSQTRDCNTQPC 2882
Score = 98.2 bits (243), Expect = 3e-20
Identities = 104/452 (23%), Positives = 152/452 (33%), Gaps = 116/452 (25%)
Query: 438 DTPETCIYSNWSPWSACSSSTCDKGKRMR---------------QRMLKAQLDLSVPCPD 482
D P+ ++S+W PW CS S C G+++R R Q+ CP
Sbjct: 3641 DCPDPGVWSSWGPWEDCSVS-CGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGCPA 3699
Query: 483 TQDFQPCM-GPGC----------------SDEDGSTCTMSEW------ITWSPCSISCGM 519
+ ++ C G GC E+G C + + PC ++ +
Sbjct: 3700 GRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECPCVLTAWL 3759
Query: 520 GMRSRERYVKQFPEDGSVCTLPTEETEKCTVNE--------ECSPSSCLMTE-----WGE 566
G L + +T + + CS C + W
Sbjct: 3760 LQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDCFEADGGFGPWSP 3819
Query: 567 WDECSATC-GMGMKKRHR--MIKMNPADGSMCKAETSQAEKCMMPEC-----------HT 612
W CS +C G+G + R R ++ M G C+ E C P+C
Sbjct: 3820 WGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGPRQDLE-CPSPDCPGAEGSTVEPVTG 3878
Query: 613 IPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPEC---PI-- 667
+P PWS WS CS +C R R L D Q C LP C P+
Sbjct: 3879 LPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCLANCTMGDPLQERPCNLPSCTELPVCP 3938
Query: 668 -------DCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETV----QRKKCR 716
+C T W+ W C++SCG G R R + P GG CP + +R+ C
Sbjct: 3939 GPGCGAGNCSWTSWAPWEPCSRSCGVGQQRRLRAYR-PPGPGGHWCPNILTAYQERRFCN 3997
Query: 717 IRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQE 776
+R C PG R W+ WS C + CGGG
Sbjct: 3998 LRAC------------------------------PVPGGWSR-WSPWSWCDRSCGGGQSL 4026
Query: 777 RYMTVKKRFKSSQFTSCK-DKKEIRACNVHPC 807
R + + C ++ + R CN PC
Sbjct: 4027 RSRSCSSPPSKNGGAPCAGERHQARLCNPMPC 4058
Score = 94.0 bits (232), Expect = 5e-19
Identities = 110/427 (25%), Positives = 140/427 (32%), Gaps = 116/427 (27%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDL--SVPCP-DTQDFQPCMGPGCSD 496
P C +S WS W+ C S C G R R R PC D Q+ Q C ++
Sbjct: 2713 PLPCGWSAWSSWAPCDRS-CGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTE 2771
Query: 497 EDGSTCTMSEWITWSPCSISC-----GMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVN 551
G T W +WS CS SC G G RSR R P D S P + T++
Sbjct: 2772 VFGWT----PWTSWSSCSQSCLAPGGGPGWRSRSRLCPS-PGDSSC---PGDATQE---- 2819
Query: 552 EECSPSSCLMTE----WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKC-- 605
E CSP C + W W CSA C G++ R R + C SQ C
Sbjct: 2820 EPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNT 2879
Query: 606 -----MMPE---------CHT----IPCLLSPWSEWSDCSVTCGKGMRTRQRMLK----- 642
PE CH P L +C+ C G +
Sbjct: 2880 QPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASC 2939
Query: 643 ------------------SLAELGDCNEDLEQVEK--CMLPECPIDCELTEWSQWSECNK 682
++A L CN K C CP+ C + W+ WS C+
Sbjct: 2940 LPRSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSC 2999
Query: 683 SCGKGHVIRTRMIQMEPQ-FGGAPCP-ETVQRKKCRIRKCLRNPSIQKLRWREARESRRS 740
SC G R R P FGGA C T++ + C +R C
Sbjct: 3000 SCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPC-------------------- 3039
Query: 741 EQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIR 800
PG W WS C+ CGGG + R S + E
Sbjct: 3040 ----------PGPGGE---WGPWSPCSVPCGGGYRNRTR-----------GSSRSLMEFS 3075
Query: 801 ACNVHPC 807
C + PC
Sbjct: 3076 TCGLQPC 3082
Score = 92.8 bits (229), Expect = 1e-18
Identities = 108/461 (23%), Positives = 150/461 (32%), Gaps = 101/461 (21%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQD-FQPCMGPGCSDED 498
PE C++S+WS W+ CS + + Q PC F+PC+ CS ED
Sbjct: 4363 PEECVWSSWSSWTRCSCRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLISNCS-ED 4421
Query: 499 GSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPT---EETEKCTVNEECS 555
T SPC+ C + + + P C P E+ C EEC+
Sbjct: 4422 SCTPPFEFHACGSPCAGLCATHLS--HQLCQDLPPCQPGCYCPKGLLEQAGGCIPPEECN 4479
Query: 556 --------------PSSCL--------------------------MTEWGEWDECS---- 571
P L ++EW EW C
Sbjct: 4480 CWHTSAAGAGMTLAPGDRLQLGCKECECRRGELHCTSQGCQGLLPLSEWSEWSPCGPCLP 4539
Query: 572 ---------------------------ATCGMGMKKRHRMIKMNPADGS-------MCKA 597
A + RHR+ ++PA G +C A
Sbjct: 4540 PSALAPASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLC-LDPATGRPWTGAPHLCTA 4598
Query: 598 ETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQV 657
SQ C P C S W WS C V C G R R R ++L G C E Q
Sbjct: 4599 PLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCG-GGCREPWAQ- 4656
Query: 658 EKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQ--MEPQFGGAPCP--ETVQRK 713
E C CP +CE + +C C +Q P G CP + VQ
Sbjct: 4657 ESCNGGPCP-ECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQDG 4715
Query: 714 KC-RIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCR------MRPWTAWSEC 766
+C I C W A + + + C + PW+AWS C
Sbjct: 4716 RCVPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWSSC 4775
Query: 767 TKLCGGGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
+ CGGG ER+ T + +D ++ + CN+ PC
Sbjct: 4776 SAPCGGGTMERHRTCEGG-PGVAPCQAQDTEQRQECNLQPC 4815
Score = 90.9 bits (224), Expect = 4e-18
Identities = 89/344 (25%), Positives = 124/344 (36%), Gaps = 81/344 (23%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPC-----------------PDTQDFQ 487
+S W+PWS CS+S C + R R A+ +VP P+ ++ +
Sbjct: 3186 WSPWTPWSQCSAS-CGPARCHRHRFC-ARSPSAVPSTVAPLPLPATPTPLCSGPEAEE-E 3242
Query: 488 PCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDG--SVCTLPTEET 545
PC+ GC G W WS CS SCG G+RSR R Q P G C P +
Sbjct: 3243 PCLLQGCDRAGG----WGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQG 3298
Query: 546 EKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKR-HRMIKMNP-----------ADGS 593
E C C ++C E E+ C C H + + P ++G+
Sbjct: 3299 EVCQALP-CPVTNCTAIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPPGQVLSSNGA 3357
Query: 594 MCK----------------------AETSQAEKCMMPE----CHTIPCLLS----PWSEW 623
+C A C E C +PC + PWSEW
Sbjct: 3358 ICVQPGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEW 3417
Query: 624 SDCSVTCGKGMRTRQRMLKSLAE-------LGDCNEDLEQVEKCMLPE---CPIDCELTE 673
+ CS C R+R R G+ E Q ++ P CP+D
Sbjct: 3418 TMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPVDGAWGP 3477
Query: 674 WSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCP-ETVQRKKCR 716
W WS C+ G+ H R P+ GG PCP Q + C+
Sbjct: 3478 WGPWSPCDMCLGQSHRSRACSRPPTPE-GGRPCPGNHTQSRPCQ 3520
Score = 89.7 bits (221), Expect = 1e-17
Identities = 93/343 (27%), Positives = 124/343 (36%), Gaps = 76/343 (22%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQ------LDLSVPCPDTQ--DFQPCMG 491
P C +S W+ WS CS S C+ G R R R A + P + + +PC G
Sbjct: 2983 PVACGWSPWTLWSLCSCS-CNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPG 3041
Query: 492 PGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTL-----PTE--- 543
PG EW WSPCS+ CG G R+R R + + S C L P
Sbjct: 3042 PG-----------GEWGPWSPCSVPCGGGYRNRTRGSSRSLMEFSTCGLQPCAGPVPGMC 3090
Query: 544 ETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMN----PADGSMCKAE- 598
+K ++ P+SC E + TC G M+ +N P C E
Sbjct: 3091 PRDKQWLDCAQGPASC--AELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEG 3148
Query: 599 ---------TSQAEKC-----MMPECHTIPC-----LLSPWSEWSDCSVTCGKGMRTRQR 639
E C ++ C + PC SPW+ WS CS +CG R R
Sbjct: 3149 HLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGPARCHRHR 3208
Query: 640 ML--------KSLAEL-------GDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSC 684
++A L C+ + E C+L C W WS C++SC
Sbjct: 3209 FCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPWSHCSRSC 3268
Query: 685 GKGHVIRTRMIQMEPQFG-GAPCP------ETVQRKKCRIRKC 720
G G RTR P G G C E Q C + C
Sbjct: 3269 GGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCPVTNC 3311
Score = 88.6 bits (218), Expect = 2e-17
Identities = 50/145 (34%), Positives = 71/145 (48%), Gaps = 12/145 (8%)
Query: 588 NPADGSMCKAETSQAEK-C-MMPECHT-------IPCLLSPWSEWSDCSVTCGKGMR-TR 637
+P+ S E AE+ C + P+C + C+L+PWS WS CS +CG G+ R
Sbjct: 2465 SPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWSSCSRSCGLGLTFQR 2524
Query: 638 QRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTR-MIQ 696
Q +L+ G C D + + C + CP+ W W C+ SCG GH R R +
Sbjct: 2525 QELLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVD 2584
Query: 697 MEPQFGGAPCPETVQ-RKKCRIRKC 720
P+ GGAPCP Q R C ++ C
Sbjct: 2585 PPPKNGGAPCPGASQERAPCGLQPC 2609
Score = 87.4 bits (215), Expect = 5e-17
Identities = 79/301 (26%), Positives = 109/301 (36%), Gaps = 62/301 (20%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRM---------LKAQLDLSVPCPDTQDFQPCM 490
P C +S+WS WS CS S +G++ R R + + S PCP QP
Sbjct: 4157 PTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCP-----QPSC 4211
Query: 491 GPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTV 550
P C S W+ SC +G +C E+TE C V
Sbjct: 4212 PPLCLQGTRSRTLGDSWLQGECQRCSC--------------TPEGVIC----EDTE-CAV 4252
Query: 551 NEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPEC 610
E T W W +C +CG G + R R + A ++ C+ P+
Sbjct: 4253 PE-------AWTLWSSWSDCPVSCGGGNQVRTRACR--------AAAPHHRSPPCLGPDT 4297
Query: 611 HT----IPCLLS--PWSEWSDCSVTCGKGMRTRQRMLKSLAELGD--CNEDLEQVEK--C 660
T P LL W W CS +CG G+ +R L D CN ++ C
Sbjct: 4298 QTRQQPCPGLLEACSWGPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLHLDTQGC 4357
Query: 661 MLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC 720
CP +C + WS W+ C SC +++ R P GA R R C
Sbjct: 4358 YSGPCPEECVWSSWSSWTRC--SCRV--LVQQRYRHQGPASRGARAGAPCTRLDGHFRPC 4413
Query: 721 L 721
L
Sbjct: 4414 L 4414
Score = 84.7 bits (208), Expect = 3e-16
Identities = 103/416 (24%), Positives = 145/416 (34%), Gaps = 111/416 (26%)
Query: 434 KDEDDTPETC----IYSNWSPWSACSSSTCDKGKRMRQRMLK--AQLDLSVPCPDTQ--- 484
++E +P C I+ W+PWS CS+ CD G + R R A D + P P +Q
Sbjct: 2818 QEEPCSPPVCPVPSIWGLWAPWSTCSAP-CDGGIQTRGRSCSSLAPGDTTCPGPHSQTRD 2876
Query: 485 -DFQPC-----------------------------MGPG--CSD--EDGSTCTMSEWITW 510
+ QPC GPG C+ G TC ++
Sbjct: 2877 CNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHN 2936
Query: 511 SPC--SISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWD 568
+ C C + + Y C T + K E P +C + W W
Sbjct: 2937 ASCLPRSQCPCQLHG-QLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWS 2995
Query: 569 ECSATCGMGMKKRHRMIKMNPA--DGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDC 626
CS +C +G+++R R PA G+ C+ T +AE C + C P W WS C
Sbjct: 2996 LCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPC---PGPGGEWGPWSPC 3052
Query: 627 SVTCGKGMRTRQR-MLKSLAELGDCNEDLEQVEKCMLP---ECPIDCELTEWSQWSEC-- 680
SV CG G R R R +SL E C ++ C P CP D QW +C
Sbjct: 3053 SVPCGGGYRNRTRGSSRSLMEFSTCG-----LQPCAGPVPGMCPRD------KQWLDCAQ 3101
Query: 681 --------------NKSCGKGHVIRTRMIQME---PQFGGAPC--------PETVQRKKC 715
N++C G + M+ + PC P + + C
Sbjct: 3102 GPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRPC 3161
Query: 716 RIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCG 771
C+ W A EGE PWT WS+C+ CG
Sbjct: 3162 ENCSCVSGLIANCSSWPCA-------------EGEP----TWSPWTPWSQCSASCG 3200
Score = 83.6 bits (205), Expect = 7e-16
Identities = 88/362 (24%), Positives = 123/362 (33%), Gaps = 96/362 (26%)
Query: 443 CIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDT----QDFQPCMGPGCSDED 498
C +++W+PW CS S C G++ R R + CP+ Q+ + C C
Sbjct: 3947 CSWTSWAPWEPCSRS-CGVGQQRRLRAYRPPGPGGHWCPNILTAYQERRFCNLRACPVPG 4005
Query: 499 GSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPED--GSVCTLPTEETEKC-------- 548
G S W WS C SCG G R R P G+ C + C
Sbjct: 4006 G----WSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAG 4061
Query: 549 --------TVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNP----------- 589
T C P C + G + C G + ++ +
Sbjct: 4062 CPAGMEVVTCANRC-PRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCT 4120
Query: 590 -------ADGSM-------CKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCG-KGM 634
A GS C + Q P C S WS WS CS +CG +G
Sbjct: 4121 DAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTHCAWSHWSAWSPCSHSCGPRGQ 4180
Query: 635 RTRQRMLKSLAELGDCNEDLEQVEKCMLPECP---------------------------- 666
++R R S + +C E+ Q + C P CP
Sbjct: 4181 QSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGECQRCSCTP 4240
Query: 667 --IDCELTE---------WSQWSECNKSCGKGHVIRTRMIQ-MEPQFGGAPC--PETVQR 712
+ CE TE WS WS+C SCG G+ +RTR + P PC P+T R
Sbjct: 4241 EGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQTR 4300
Query: 713 KK 714
++
Sbjct: 4301 QQ 4302
Score = 81.3 bits (199), Expect = 3e-15
Identities = 86/358 (24%), Positives = 116/358 (32%), Gaps = 94/358 (26%)
Query: 472 AQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQF 531
A+LD C C C C S W WS CS SC +G+R R R
Sbjct: 2960 ARLDSCNNCTCVSGKMACTSERCP----VACGWSPWTLWSLCSCSCNVGIRRRFRAGTAP 3015
Query: 532 PE--DGSVCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNP 589
P G+ C PT E E C++ P EWG W CS CG G + R R
Sbjct: 3016 PAAFGGAECQGPTMEAEFCSLRPCPGPGG----EWGPWSPCSVPCGGGYRNRTR-----G 3066
Query: 590 ADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSV----------------TCGKG 633
+ S+ + T + C P +P + +W DC+ TC G
Sbjct: 3067 SSRSLMEFSTCGLQPCAGP----VPGMCPRDKQWLDCAQGPASCAELSAPRGTNQTCHPG 3122
Query: 634 MRTRQRML---KSLAELGDC------------NEDLEQVEKC-----MLPECPI------ 667
ML DC + + E C ++ C
Sbjct: 3123 CHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEG 3182
Query: 668 DCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQ 727
+ + W+ WS+C+ SCG R R C R+PS
Sbjct: 3183 EPTWSPWTPWSQCSASCGPARCHRHRF-------------------------CARSPSAV 3217
Query: 728 KLRWREARESRRSEQLKEESEGEQFP----GCRMR----PWTAWSECTKLCGGGIQER 777
L E E+ P GC PW WS C++ CGGG++ R
Sbjct: 3218 PSTVAPLPLPATPTPLCSGPEAEEEPCLLQGCDRAGGWGPWGPWSHCSRSCGGGLRSR 3275
Score = 77.0 bits (188), Expect = 6e-14
Identities = 110/446 (24%), Positives = 155/446 (34%), Gaps = 98/446 (21%)
Query: 433 EKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLD--LSVPC--PDTQDFQ- 487
E E PE ++ WS WS C S C G ++R R +A S PC PDTQ Q
Sbjct: 4246 EDTECAVPEA--WTLWSSWSDCPVS-CGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQ 4302
Query: 488 PCMG--PGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRER-----YVKQFPEDGSVCTL 540
PC G CS W W PCS SCG G+ SR K P S T
Sbjct: 4303 PCPGLLEACS-----------WGPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNS--TF 4349
Query: 541 PTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPAD-GSMCKAET 599
+T+ C + C P C+ + W W CS + + RH+ A G+ C
Sbjct: 4350 LHLDTQGC-YSGPC-PEECVWSSWSSWTRCSCRVLVQQRYRHQGPASRGARAGAPCTRLD 4407
Query: 600 SQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNED------ 653
C++ C C +P E+ C C G+ + +L C
Sbjct: 4408 GHFRPCLISNCSEDSC--TPPFEFHACGSPCA-GLCATHLSHQLCQDLPPCQPGCYCPKG 4464
Query: 654 -LEQVEKCMLPE----------------CPID--------CE------------------ 670
LEQ C+ PE P D CE
Sbjct: 4465 LLEQAGGCIPPEECNCWHTSAAGAGMTLAPGDRLQLGCKECECRRGELHCTSQGCQGLLP 4524
Query: 671 LTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPC------PETVQRKKCRIRKCLRNP 724
L+EWS+WS C + +E + P + ++ R R CL +P
Sbjct: 4525 LSEWSEWSPCGPCLPPSALAPASRTALEEHWLRDPTGLSPTLAPLLASEQHRHRLCL-DP 4583
Query: 725 SIQKLRWREARE---SRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTV 781
+ + W A + S+Q G C+ W WS C C GG + R+
Sbjct: 4584 ATGR-PWTGAPHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGFRLRW--- 4639
Query: 782 KKRFKSSQFTSCKDKKEIRACNVHPC 807
+ ++ C++ +CN PC
Sbjct: 4640 -REAEALCGGGCREPWAQESCNGGPC 4664
Score = 65.9 bits (159), Expect = 1e-10
Identities = 59/231 (25%), Positives = 84/231 (36%), Gaps = 42/231 (18%)
Query: 435 DEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMG--- 491
D P++C +S W PWS C C G R+R R +A+ C + + C G
Sbjct: 4608 DPGACPDSCQWSLWGPWSPCQVP-CSGGFRLRWR--EAEALCGGGCREPWAQESCNGGPC 4664
Query: 492 PGCSDED-------GSTCTMSEWITWS-------PCSISCGMGMRSRERYVKQFPEDGSV 537
P C +D + C S W PC C + + P
Sbjct: 4665 PECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQDGRCVPISSCR 4724
Query: 538 CTLPTE--------------ETEKCT-VNEE--CSPSSC-LMTEWGEWDECSATCGMGMK 579
C LP+ + + CT VNE C C ++ W W CSA CG G
Sbjct: 4725 CGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWSAWSSCSAPCGGGTM 4784
Query: 580 KRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTC 630
+RHR + P +T Q ++C + C P P S C+ +C
Sbjct: 4785 ERHRTCEGGPGVAPCQAQDTEQRQECNLQPCPECP----PGQVLSACATSC 4831
Score = 63.5 bits (153), Expect = 7e-10
Identities = 34/90 (37%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 619 PWSEWSDCSVTCGKGMRTRQRMLKSLA--ELGDCNEDLEQVEKCMLPECPIDCELTEWSQ 676
PWS W CS TCG + R R L L +C Q + C CP+D E + WS
Sbjct: 1699 PWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVDGEWSTWSP 1758
Query: 677 WSECNKSCGKGHVIRTRMIQMEPQFGGAPC 706
WS C++ C +G + R R PQ GG C
Sbjct: 1759 WSVCSEPC-RGTMTRQRQCH-SPQNGGRTC 1786
Score = 63.5 bits (153), Expect = 7e-10
Identities = 63/239 (26%), Positives = 83/239 (34%), Gaps = 55/239 (23%)
Query: 537 VCTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCK 596
+CT P + C C P SC + WG W C C G + R R + G C+
Sbjct: 4595 LCTAPLSQQRLCPDPGAC-PDSCQWSLWGPWSPCQVPCSGGFRLRWR--EAEALCGGGCR 4651
Query: 597 AETSQAEKCM---MPECHT-----------------------IPCLLSPWSEWSDC---- 626
+Q E C PEC + CL P C
Sbjct: 4652 EPWAQ-ESCNGGPCPECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQ 4710
Query: 627 -----------SVTCG-KGMRTRQRMLKSLAELGDCNEDLEQVEKCMLP--ECPIDCELT 672
S CG + + A DC E + P ECP+ L
Sbjct: 4711 LVQDGRCVPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPV---LG 4767
Query: 673 EWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPC--PETVQRKKCRIRKCLRNPSIQKL 729
WS WS C+ CG G + R R + P G APC +T QR++C ++ C P Q L
Sbjct: 4768 PWSAWSSCSAPCGGGTMERHRTCEGGP--GVAPCQAQDTEQRQECNLQPCPECPPGQVL 4824
Score = 62.0 bits (149), Expect = 2e-09
Identities = 78/328 (23%), Positives = 115/328 (35%), Gaps = 48/328 (14%)
Query: 492 PGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVN 551
P C D S W W CS+SCG G + R R + P G T T+ C
Sbjct: 3640 PDCPDPG----VWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVC--R 3693
Query: 552 EECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECH 611
E P+ L E + C +C + ++ +G C T Q + EC
Sbjct: 3694 EAGCPAGRLYRECQPGEGCPFSCA-HVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQEC- 3751
Query: 612 TIPCLLSPW------SEWSDCSVTCGKG--MRTRQRMLKSLAELGDCNEDLEQVEKCMLP 663
PC+L+ W + D G G + + Q + S + L C L
Sbjct: 3752 --PCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKL----SCSLD 3805
Query: 664 EC-PIDCELTEWSQWSECNKSCGKGHVIRTRMIQ---MEPQFGGAPCPETVQRKKCRIRK 719
+C D WS W C++SCG G RTR Q P G C Q +C
Sbjct: 3806 DCFEADGGFGPWSPWGPCSRSCG-GLGTRTRSRQCVLTMPTLSGQGCRGPRQDLECPSPD 3864
Query: 720 CLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYM 779
C E E + PG PW++WS C++ C + +
Sbjct: 3865 C------------PGAEGSTVEPV------TGLPG-GWGPWSSWSPCSRSCTDPARPAWR 3905
Query: 780 TVKKRFKSSQFTSCKDKKEIRACNVHPC 807
+ + ++ + D + R CN+ C
Sbjct: 3906 SRTRLCLAN--CTMGDPLQERPCNLPSC 3931
Score = 57.8 bits (138), Expect = 4e-08
Identities = 75/302 (24%), Positives = 114/302 (37%), Gaps = 63/302 (20%)
Query: 448 WSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQ-DFQPCMGPGCSDEDGSTCTMSE 506
WSPW CS + G+ +R L + CP + Q C C + E
Sbjct: 1700 WSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVD-------GE 1752
Query: 507 WITWSP---CSISCGMGMRSRERYVKQFPEDGSVC-TLP-----TEETEKCTVNEECSPS 557
W TWSP CS C G +R+R G C LP T +T+ C + C +
Sbjct: 1753 WSTWSPWSVCSEPC-RGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCP-QDGCPNA 1810
Query: 558 SCLMTEWGE--WDECSATCGMGMKKRHRMIKMNP-----ADGSMCKAETSQAEK--CMMP 608
+C GE + C A C + + P + G C + C+ P
Sbjct: 1811 TCS----GELMFQPC-APCPLTCDDISGQVTCPPDWPCGSPGCWCPEGQVLGSEGWCVWP 1865
Query: 609 ECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCML-PECPI 667
PCL+ W G R +K+ +L C + + +C L P+C +
Sbjct: 1866 --RQCPCLVDGARYW--------PGQR-----IKADCQLCICQDG--RPRRCRLNPDCAV 1908
Query: 668 DCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCR-----IRKCLR 722
DC + WS W++C CG ++ IQ + P P + + ++CR R+C
Sbjct: 1909 DCGWSSWSPWAKCLGPCG------SQSIQWSFRSSNNPRP-SGRGRQCRGIHRKARRCQT 1961
Query: 723 NP 724
P
Sbjct: 1962 EP 1963
Score = 57.4 bits (137), Expect = 5e-08
Identities = 98/438 (22%), Positives = 134/438 (30%), Gaps = 135/438 (30%)
Query: 448 WSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDG-------- 499
WS W+ CS C R R R + CP Q G C+ E G
Sbjct: 3414 WSEWTMCSQP-CRGQTRSRSR--------ACACPTPQHG----GAPCTGEAGEAGAQHQR 3460
Query: 500 ------STCTMS----EWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCT 549
+TC + W WSPC + G RSR PE G C ++ C
Sbjct: 3461 EACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQ 3520
Query: 550 VNE-ECS---------------PSSCLMTEWGEWDE-----CSATCG------------- 575
N +C+ P SC G + C TCG
Sbjct: 3521 ENSTQCTDCGGGQSLHPCGQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQLSQDGLCV 3580
Query: 576 -------------MGMKKRHRM----------------IKMNPADGSMCKAETSQAEKCM 606
MG+ + + P D C A Q ++
Sbjct: 3581 PPAHCRCQYQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQE-- 3638
Query: 607 MPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLE-QVEKCMLPEC 665
+P+C P + S W W DCSV+CG G + R R G + + C C
Sbjct: 3639 VPDCPD-PGVWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGC 3697
Query: 666 PIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPE-TVQRKKCRIRKC---- 720
P E C SC HV + E G CPE T Q + +++C
Sbjct: 3698 PAGRLYRECQPGEGCPFSC--AHVTQQVGCFSEGCEEGCHCPEGTFQHRLACVQECPCVL 3755
Query: 721 -----------LRNP-----------SIQKLRWR----EARESRRSEQLKEESEGEQFPG 754
+ +P S Q LR + S L + E + G
Sbjct: 3756 TAWLLQELGATIGDPGQPLGPGDELDSGQTLRTSCGNCSCAHGKLSCSLDDCFEADGGFG 3815
Query: 755 CRMRPWTAWSECTKLCGG 772
PW+ W C++ CGG
Sbjct: 3816 ----PWSPWGPCSRSCGG 3829
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/172 (24%), Positives = 62/172 (36%), Gaps = 21/172 (12%)
Query: 450 PWSACSSSTCDKGKRMRQRMLKAQL---DLS--VPCPDTQDFQPCMGPGCSDEDGSTCTM 504
P C ++TC G+ M Q L D+S V CP PC PGC +G
Sbjct: 1803 PQDGCPNATCS-GELMFQPCAPCPLTCDDISGQVTCPPDW---PCGSPGCWCPEGQVLGS 1858
Query: 505 SEWITW---SPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLM 561
W W PC + +R ++ D +C +C +N +C+ C
Sbjct: 1859 EGWCVWPRQCPCLVD-----GARYWPGQRIKADCQLCICQDGRPRRCRLNPDCA-VDCGW 1912
Query: 562 TEWGEWDECSATCGMGMKKRHRMIKMNP---ADGSMCKAETSQAEKCMMPEC 610
+ W W +C CG + NP G C+ +A +C C
Sbjct: 1913 SSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPC 1964
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 102 bits (255), Expect = 1e-21
Identities = 78/255 (30%), Positives = 105/255 (41%), Gaps = 26/255 (10%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRML---KAQLDLSVPCPDTQDF--QPCMGPGCSDEDG 499
+S WS W+ C S TC +G ++R R Q V P T ++ Q C C E G
Sbjct: 80 WSLWSTWAPC-SVTCSEGSQLRYRRCVGWNGQCSGKV-APGTLEWQLQACEDQQCCPEMG 137
Query: 500 STCTMSEWITWSPCSISCGMGMRSRERYVKQ-FPEDGSVCTLPTEETEKCTVNEECSPSS 558
S W W PCS++C G R+R R P+ G C +E+E C + C P+
Sbjct: 138 G---WSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVC-PTH 193
Query: 559 CLMTEWGEWDECSATC--GMGMKKRHRMIKMNPAD------GSMCKAETSQAEKCM-MPE 609
WG W CSA+C G K R K + + G C + +C +P
Sbjct: 194 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP 253
Query: 610 CHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLK-SLAELGD--CNEDLEQVEKC-MLPEC 665
C + PW S C VTCG G QR + + G C D + C C
Sbjct: 254 C-PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPC 312
Query: 666 PIDCELTEWSQWSEC 680
P+D E W +WS C
Sbjct: 313 PVDGEWDSWGEWSPC 327
Score = 88.2 bits (217), Expect = 3e-17
Identities = 75/278 (26%), Positives = 106/278 (38%), Gaps = 35/278 (12%)
Query: 434 KDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLD-LSVPCP-DTQDFQPCMG 491
+D+ PE +S W PW CS TC KG R R+R CP Q+ + C
Sbjct: 128 EDQQCCPEMGGWSGWGPWEPCSV-TCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDT 186
Query: 492 PGCSDEDGSTCTMSEWITWSPCSISCGMG------MRSRERYVKQFPED--GSVCTLPTE 543
G+ T W W+PCS SC G RSR+ + + G C
Sbjct: 187 QQVCPTHGAWAT---WGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAY 243
Query: 544 ETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIK--MNPADGSMCKAETSQ 601
E +CT C P + WG C TCG+G R + G C + ++
Sbjct: 244 EQRRCTGLPPC-PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATR 302
Query: 602 AEKCMMPECHTIPCLLS----PWSEWSDC------SVTCGK--GMRTRQRMLKSLAELGD 649
C +PC + W EWS C S++C + G ++R R + G
Sbjct: 303 THICNT----AVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGH 358
Query: 650 -CNEDLEQVEKCM-LPECPIDCELTEWSQWSECNKSCG 685
C + + C + CP+ +EWS W C CG
Sbjct: 359 RCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
Score = 85.1 bits (209), Expect = 2e-16
Identities = 62/234 (26%), Positives = 87/234 (37%), Gaps = 24/234 (10%)
Query: 487 QPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPED--GSVCTLPTEE 544
QPC P S W TW+PCS++C G + R R + G V E
Sbjct: 73 QPCRSP----------RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEW 122
Query: 545 TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIK-MNPADGSMCKAETSQAE 603
+ +++C P + WG W+ CS TC G + R R P G C + ++E
Sbjct: 123 QLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESE 182
Query: 604 KCMMPECHTIPCLLSPWSEWSDCSVTCGKG----MRTRQRMLKSLAEL-----GDCNEDL 654
C + + W W+ CS +C G TR R + C
Sbjct: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
Query: 655 EQVEKCM-LPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQME-PQFGGAPC 706
+ +C LP CP+ W S C +CG G + R PQ GG C
Sbjct: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC 296
Score = 67.8 bits (164), Expect = 4e-11
Identities = 59/223 (26%), Positives = 78/223 (34%), Gaps = 42/223 (18%)
Query: 564 WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS------QAEKCMMPECHTIPCLL 617
W W CS TC G + R+R C + + Q + C +C
Sbjct: 83 WSTWAPCSVTCSEGSQLRYRRCV---GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAEL--GDCNEDLEQVEKCMLPE-CPIDCELTEW 674
S W W CSVTC KG RTR+R A G C ++ E C + CP W
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW 199
Query: 675 SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREA 734
W+ C+ SC GG P+ + +KC + + P + A
Sbjct: 200 GPWTPCSASC----------------HGGPHEPKETRSRKCSAPEPSQKPPGKPCPGL-A 242
Query: 735 RESRRSEQLKEESEGEQFPGCRMR----PWTAWSECTKLCGGG 773
E RR L P C + PW S C CG G
Sbjct: 243 YEQRRCTGL---------PPCPVAGGWGPWGPVSPCPVTCGLG 276
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 102 bits (255), Expect = 1e-21
Identities = 78/255 (30%), Positives = 105/255 (41%), Gaps = 26/255 (10%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRML---KAQLDLSVPCPDTQDF--QPCMGPGCSDEDG 499
+S WS W+ C S TC +G ++R R Q V P T ++ Q C C E G
Sbjct: 80 WSLWSTWAPC-SVTCSEGSQLRYRRCVGWNGQCSGKV-APGTLEWQLQACEDQQCCPEMG 137
Query: 500 STCTMSEWITWSPCSISCGMGMRSRERYVKQ-FPEDGSVCTLPTEETEKCTVNEECSPSS 558
S W W PCS++C G R+R R P+ G C +E+E C + C P+
Sbjct: 138 G---WSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVC-PTH 193
Query: 559 CLMTEWGEWDECSATC--GMGMKKRHRMIKMNPAD------GSMCKAETSQAEKCM-MPE 609
WG W CSA+C G K R K + + G C + +C +P
Sbjct: 194 GAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPP 253
Query: 610 CHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLK-SLAELGD--CNEDLEQVEKC-MLPEC 665
C + PW S C VTCG G QR + + G C D + C C
Sbjct: 254 C-PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPC 312
Query: 666 PIDCELTEWSQWSEC 680
P+D E W +WS C
Sbjct: 313 PVDGEWDSWGEWSPC 327
Score = 88.2 bits (217), Expect = 3e-17
Identities = 75/278 (26%), Positives = 106/278 (38%), Gaps = 35/278 (12%)
Query: 434 KDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLD-LSVPCP-DTQDFQPCMG 491
+D+ PE +S W PW CS TC KG R R+R CP Q+ + C
Sbjct: 128 EDQQCCPEMGGWSGWGPWEPCSV-TCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDT 186
Query: 492 PGCSDEDGSTCTMSEWITWSPCSISCGMG------MRSRERYVKQFPED--GSVCTLPTE 543
G+ T W W+PCS SC G RSR+ + + G C
Sbjct: 187 QQVCPTHGAWAT---WGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAY 243
Query: 544 ETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIK--MNPADGSMCKAETSQ 601
E +CT C P + WG C TCG+G R + G C + ++
Sbjct: 244 EQRRCTGLPPC-PVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATR 302
Query: 602 AEKCMMPECHTIPCLLS----PWSEWSDC------SVTCGK--GMRTRQRMLKSLAELGD 649
C +PC + W EWS C S++C + G ++R R + G
Sbjct: 303 THICNT----AVPCPVDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRKFDGH 358
Query: 650 -CNEDLEQVEKCM-LPECPIDCELTEWSQWSECNKSCG 685
C + + C + CP+ +EWS W C CG
Sbjct: 359 RCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCMPPCG 396
Score = 85.1 bits (209), Expect = 2e-16
Identities = 62/234 (26%), Positives = 87/234 (37%), Gaps = 24/234 (10%)
Query: 487 QPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPED--GSVCTLPTEE 544
QPC P S W TW+PCS++C G + R R + G V E
Sbjct: 73 QPCRSP----------RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEW 122
Query: 545 TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIK-MNPADGSMCKAETSQAE 603
+ +++C P + WG W+ CS TC G + R R P G C + ++E
Sbjct: 123 QLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESE 182
Query: 604 KCMMPECHTIPCLLSPWSEWSDCSVTCGKG----MRTRQRMLKSLAEL-----GDCNEDL 654
C + + W W+ CS +C G TR R + C
Sbjct: 183 ACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLA 242
Query: 655 EQVEKCM-LPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQME-PQFGGAPC 706
+ +C LP CP+ W S C +CG G + R PQ GG C
Sbjct: 243 YEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFC 296
Score = 67.8 bits (164), Expect = 4e-11
Identities = 59/223 (26%), Positives = 78/223 (34%), Gaps = 42/223 (18%)
Query: 564 WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETS------QAEKCMMPECHTIPCLL 617
W W CS TC G + R+R C + + Q + C +C
Sbjct: 83 WSTWAPCSVTCSEGSQLRYRRCV---GWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAEL--GDCNEDLEQVEKCMLPE-CPIDCELTEW 674
S W W CSVTC KG RTR+R A G C ++ E C + CP W
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATW 199
Query: 675 SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREA 734
W+ C+ SC GG P+ + +KC + + P + A
Sbjct: 200 GPWTPCSASC----------------HGGPHEPKETRSRKCSAPEPSQKPPGKPCPGL-A 242
Query: 735 RESRRSEQLKEESEGEQFPGCRMR----PWTAWSECTKLCGGG 773
E RR L P C + PW S C CG G
Sbjct: 243 YEQRRCTGL---------PPCPVAGGWGPWGPVSPCPVTCGLG 276
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 97.8 bits (242), Expect = 3e-20
Identities = 86/364 (23%), Positives = 127/364 (34%), Gaps = 73/364 (20%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGS-TCT 503
+ WSPW C D R P P C+GP + S
Sbjct: 612 FGPWSPWQPCEHLDGDNSGSCLCRARSC----DSPRPRCGGLD-CLGPAIHIANCSRNGA 666
Query: 504 MSEWITWSPCSISCGMGMRSRERYVKQFP--EDGSVCTLPTEETEKCTVNEECSPSSCLM 561
+ W +W+ CS SCG+G + R+R G +C + E C N C P
Sbjct: 667 WTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPC-PVPIFW 725
Query: 562 TEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWS 621
WG W +CS+ CG GM+ R R + +G+ C + + C C + +PW+
Sbjct: 726 ASWGSWSKCSSNCGGGMQSRRRACE----NGNSCLGCGVEFKTCNPEGCPEVR-RNTPWT 780
Query: 622 EWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPID----CEL------ 671
W +VT G + ++ A L D + + CP D C+
Sbjct: 781 PWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEV 840
Query: 672 ----------------TEWSQWSECNKSCGKGHVIRTR-MIQMEPQFGGAPC-PETVQRK 713
W WS C++ C G +R R EP+ GG PC + + +
Sbjct: 841 LLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQ 900
Query: 714 KCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGG 773
C + C + W C WT+WS C+ CGGG
Sbjct: 901 DCNPQACPVRGA-----W----------------------SC----WTSWSPCSASCGGG 929
Query: 774 IQER 777
+R
Sbjct: 930 HYQR 933
Score = 94.4 bits (233), Expect = 4e-19
Identities = 80/284 (28%), Positives = 116/284 (40%), Gaps = 50/284 (17%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDE---DGST 501
++ WS W+ CS+S C G ++RQR S P P + C+G + + +
Sbjct: 667 WTPWSSWALCSTS-CGIGFQVRQR------SCSNPAP-RHGGRICVGKSREERFCNENTP 718
Query: 502 CTM----SEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPS 557
C + + W +WS CS +CG GM+SR R E+G+ C E + C N E P
Sbjct: 719 CPVPIFWASWGSWSKCSSNCGGGMQSRRRAC----ENGNSCLGCGVEFKTC--NPEGCPE 772
Query: 558 SCLMTEWGEWDECSAT-------------C--------GMGMKKRHRMIKMNPADGSMCK 596
T W W + T C G+ +R + PADGS
Sbjct: 773 VRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSG-S 831
Query: 597 AETSQAEKCMMPECHTIPCLLS----PWSEWSDCSVTCGKGMRTRQRMLKSLAELGD--- 649
+T + ++ T P +S W WS CS C G R R+R +
Sbjct: 832 CDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLP 891
Query: 650 CNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTR 693
C D + + C CP+ + W+ WS C+ SCG GH RTR
Sbjct: 892 CVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTR 935
Score = 77.4 bits (189), Expect = 5e-14
Identities = 72/285 (25%), Positives = 109/285 (38%), Gaps = 48/285 (16%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDG 499
P +++W WS CSS+ C G + R+R + + + C +F+ C GC +
Sbjct: 720 PVPIFWASWGSWSKCSSN-CGGGMQSRRRACENG-NSCLGCG--VEFKTCNPEGCPEVRR 775
Query: 500 STCTMSEWITWSPCSISCGMGMRSRERY----------------------VKQFPEDGSV 537
+T W W P +++ G G R +R+ + P DGS
Sbjct: 776 NT----PWTPWLPVNVTQG-GARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSG 830
Query: 538 CTLPTEETEKCTVNEECSPSSCL--MTEWGEWDECSATCGMGMKKRHRMI-KMNPADGSM 594
E + SP + WG W CS C +G + R R P +G +
Sbjct: 831 SCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGL 890
Query: 595 -CKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNED 653
C + ++ + C P+ + S W+ WS CS +CG G R R S A ED
Sbjct: 891 PCVGDAAEYQDCN-PQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAP--SPGED 947
Query: 654 L-----EQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTR 693
+ + C CP WS WSE +K G R+R
Sbjct: 948 ICLGLHTEEALCATQACP-----EGWSPWSEWSKCTDDGAQSRSR 987
Score = 73.6 bits (179), Expect = 7e-13
Identities = 55/189 (29%), Positives = 78/189 (41%), Gaps = 20/189 (10%)
Query: 445 YSNWSPWSACSSSTCDKGKRMRQRMLK--AQLDLSVPCP-DTQDFQPCMGPGCSDEDGST 501
++ W PWS+CS C+ G R+R+R + +PC D ++Q C C +
Sbjct: 856 WAAWGPWSSCSRD-CELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWS 914
Query: 502 CTMSEWITWSPCSISCGMGMRSRERY-VKQFPEDGSVCTLPTEETEKCTVNEECSPSSCL 560
C W +WSPCS SCG G R R P G L E + C
Sbjct: 915 C----WTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEG--- 967
Query: 561 MTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLL--S 618
+ W EW +C+ G + R R + S C +SQ+ C E IP +L S
Sbjct: 968 WSPWSEWSKCTDD---GAQSRSRHCEELLPGSSACAGNSSQSRPCPYSE---IPVILPAS 1021
Query: 619 PWSEWSDCS 627
E +DC+
Sbjct: 1022 SMEEATDCA 1030
Score = 63.9 bits (154), Expect = 6e-10
Identities = 67/272 (24%), Positives = 96/272 (35%), Gaps = 44/272 (16%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQ-----------P 488
PE + W+PW + + G R QR + P D Q P
Sbjct: 771 PEVRRNTPWTPWLPVNVT--QGGARQEQRF---RFTCRAPLADPHGLQFGRRRTETRTCP 825
Query: 489 CMGPGCSDED---------GSTCT------MSEWITWSPCSISCGMGMRSRERY-VKQFP 532
G G D D GST + W WS CS C +G R R+R P
Sbjct: 826 ADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEP 885
Query: 533 EDGSV-CTLPTEETEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMN-PA 590
+G + C E + C N + P + W W CSA+CG G +R R P+
Sbjct: 886 RNGGLPCVGDAAEYQDC--NPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPS 943
Query: 591 DGS-MCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAE-LG 648
G +C ++ C C WS WS+ S G ++R R + L
Sbjct: 944 PGEDICLGLHTEEALCATQACP------EGWSPWSEWSKCTDDGAQSRSRHCEELLPGSS 997
Query: 649 DCNEDLEQVEKCMLPECPIDCELTEWSQWSEC 680
C + Q C E P+ + + ++C
Sbjct: 998 ACAGNSSQSRPCPYSEIPVILPASSMEEATDC 1029
Score = 46.2 bits (108), Expect = 1e-04
Identities = 48/199 (24%), Positives = 65/199 (32%), Gaps = 52/199 (26%)
Query: 619 PWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVE--KCMLP-----ECPIDCEL 671
PWS W C G + L C+ + C+ P C +
Sbjct: 614 PWSPWQPCEHLDGDNSGS------CLCRARSCDSPRPRCGGLDCLGPAIHIANCSRNGAW 667
Query: 672 TEWSQWSECNKSCGKGHVIRTRMIQME-PQFGGAPCPETVQRKKCRIRKCLRN-PSIQKL 729
T WS W+ C+ SCG G +R R P+ GG C + + R C N P +
Sbjct: 668 TPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREE----RFCNENTPCPVPI 723
Query: 730 RWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQ 789
W W +WS+C+ CGGG+Q R R
Sbjct: 724 FWAS--------------------------WGSWSKCSSNCGGGMQSR------RRACEN 751
Query: 790 FTSCKD-KKEIRACNVHPC 807
SC E + CN C
Sbjct: 752 GNSCLGCGVEFKTCNPEGC 770
Score = 40.8 bits (94), Expect = 0.005
Identities = 32/122 (26%), Positives = 50/122 (40%), Gaps = 13/122 (10%)
Query: 436 EDDTPETC----IYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMG 491
+D P+ C +S W+ WS CS+S C G R R + P P + C+G
Sbjct: 900 QDCNPQACPVRGAWSCWTSWSPCSAS-CGGGHYQRTRSCTS------PAPSPGE-DICLG 951
Query: 492 PGCSDEDGSTCTMSE-WITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTV 550
+ +T E W WS S G +SR R+ ++ S C + ++ C
Sbjct: 952 LHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPY 1011
Query: 551 NE 552
+E
Sbjct: 1012 SE 1013
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 96.7 bits (239), Expect = 8e-20
Identities = 58/174 (33%), Positives = 81/174 (46%), Gaps = 16/174 (9%)
Query: 564 WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTI---PCLLSPW 620
W EW CS +CG G+++R R + + C+ + Q C + EC S W
Sbjct: 385 WSEWTSCSTSCGNGIQQRGRSCD---SLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHW 441
Query: 621 SEWSDCSVTCGKGMRTRQRMLKSLAELGD---CNEDLEQVEKCMLPECPIDCELTEWSQW 677
S WS CSVTCG G+ TR R+ S + + C + + + C CPI+ WS W
Sbjct: 442 SPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPW 501
Query: 678 SECNKSCGKGHVIRTRMI-QMEPQFGGAPCPETV------QRKKCRIRKCLRNP 724
C+ +CG G R+R+ PQFGG C V ++ C I CL NP
Sbjct: 502 DICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNP 555
Score = 92.4 bits (228), Expect = 1e-18
Identities = 62/202 (30%), Positives = 92/202 (45%), Gaps = 19/202 (9%)
Query: 478 VPCPDTQ--DFQPCMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDG 535
+PC + D + C P C D + S W W+ CS SCG G++ R R
Sbjct: 356 MPCSNATVPDGECC--PRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSL---N 410
Query: 536 SVCTLPTEETEKCTVNEECSP---SSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPA-- 590
+ C + +T C + +EC + W W CS TCG G+ R R+ +P+
Sbjct: 411 NRCEGSSVQTRTCHI-QECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCN-SPSPQ 468
Query: 591 -DGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKS-LAELG 648
+G C+ E + + C C I PWS W CSVTCG G++ R R+ + + G
Sbjct: 469 MNGKPCEGEARETKACKKDAC-PINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFG 527
Query: 649 --DCNEDLEQVEKCMLPECPID 668
DC D+ + + C +CPID
Sbjct: 528 GKDCVGDVTENQICNKQDCPID 549
Score = 85.9 bits (211), Expect = 1e-16
Identities = 58/197 (29%), Positives = 75/197 (38%), Gaps = 40/197 (20%)
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPI----DCELTE 673
SPWSEW+ CS +CG G++ R R SL C Q C + EC D +
Sbjct: 383 SPWSEWTSCSTSCGNGIQQRGRSCDSLNNR--CEGSSVQTRTCHIQECDKRFKQDGGWSH 440
Query: 674 WSQWSECNKSCGKGHVIRTRMIQM-EPQFGGAPCP-ETVQRKKCRIRKCLRNPSIQKLRW 731
WS WS C+ +CG G + R R+ PQ G PC E + K C+ C N W
Sbjct: 441 WSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGG-----W 495
Query: 732 REARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFT 791
PW+ W C+ CGGG+Q+R
Sbjct: 496 G--------------------------PWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGK 529
Query: 792 SC-KDKKEIRACNVHPC 807
C D E + CN C
Sbjct: 530 DCVGDVTENQICNKQDC 546
Score = 76.6 bits (187), Expect = 8e-14
Identities = 57/204 (27%), Positives = 85/204 (41%), Gaps = 16/204 (7%)
Query: 440 PETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQ-DFQPCMGPGCSDED 498
P WSPWS +S + G ++QR L+ C + + C C
Sbjct: 374 PSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCD-SLNNRCEGSSVQTRTCHIQECDKRF 432
Query: 499 GSTCTMSEWITWSPCSISCGMGMRSRERYVKQ-FPE-DGSVCTLPTEETEKCTVNEECSP 556
S W WS CS++CG G+ +R R P+ +G C ET+ C ++ P
Sbjct: 433 KQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKAC--KKDACP 490
Query: 557 SSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPA---DGSMCKAETSQAEKCMMPECHTI 613
+ W WD CS TCG G++KR R+ NP G C + ++ + C +C
Sbjct: 491 INGGWGPWSPWDICSVTCGGGVQKRSRLCN-NPTPQFGGKDCVGDVTENQICNKQDCPID 549
Query: 614 PCLLSP------WSEWSDCSVTCG 631
CL +P + + D S CG
Sbjct: 550 GCLSNPCFAGVKCTSYPDGSWKCG 573
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/147 (21%), Positives = 54/147 (36%), Gaps = 33/147 (22%)
Query: 663 PECPIDCELTEWSQWSECNKSCGKGHVIRTRMI-QMEPQFGGAPCPETVQRKKCRIRKCL 721
P D + WS+W+ C+ SCG G R R + + G+ +VQ + C I++C
Sbjct: 374 PSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGS----SVQTRTCHIQEC- 428
Query: 722 RNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTV 781
++ K++ W+ WS C+ CG G+ R
Sbjct: 429 ------------------DKRFKQDGGWSH--------WSPWSSCSVTCGDGVITRIRLC 462
Query: 782 KKRFKSSQFTSCK-DKKEIRACNVHPC 807
C+ + +E +AC C
Sbjct: 463 NSPSPQMNGKPCEGEARETKACKKDAC 489
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 93.6 bits (231), Expect = 7e-19
Identities = 89/329 (27%), Positives = 132/329 (40%), Gaps = 79/329 (24%)
Query: 513 CSISCGMGM---------RSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTE 563
CS +CG G RS + D S+ PT E E C + P +
Sbjct: 629 CSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSM--KPTPEEEPCNI----FPCPAFW-D 681
Query: 564 WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCM---MPECHTIPCLL--- 617
GEW ECS TCG+GM+ R + + A+ S+ T Q +C PE T C L
Sbjct: 682 IGEWSECSKTCGLGMQHRQVLCRQVYANRSL----TVQPYRCQHLEKPET-TSTCQLKIC 736
Query: 618 SPW---SEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLE--------QVEKCMLPECP 666
S W ++W+ CSV CG G RTR +K ++ +GD +D E +E C + C
Sbjct: 737 SEWQIRTDWTSCSVPCGVGQRTRD--VKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCA 794
Query: 667 IDCELTEWSQWSECNKSCGKGHVIRTR-MIQMEPQFGGAPCPETVQRKKCRIRKCLRNPS 725
LTEWS+ C+ CG G +RTR ++ M P + C P
Sbjct: 795 KSWFLTEWSE--RCSAECGAG--VRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPC 850
Query: 726 IQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKR- 784
K+ W F G +WS+C+ CG G Q+R + ++
Sbjct: 851 TGKVEW--------------------FAG-------SWSQCSIECGSGTQQREVICVRKN 883
Query: 785 ------FKSSQFTSCKDKKEIRACNVHPC 807
S+ + + ++C++ PC
Sbjct: 884 ADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
Score = 83.6 bits (205), Expect = 7e-16
Identities = 88/303 (29%), Positives = 125/303 (41%), Gaps = 51/303 (16%)
Query: 419 PDNVDDIVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQ---RMLKAQLD 475
P++ D PEE+ + P + + WS CS TC G + RQ R + A
Sbjct: 654 PESYCDSSMKPTPEEEPCNIFPCPAFW-DIGEWSECSK-TCGLGMQHRQVLCRQVYANRS 711
Query: 476 LSVPCPDTQDFQPCMGPGCSDEDGSTCTM---SEW---ITWSPCSISCGMGMRSRERYVK 529
L+V Q + E STC + SEW W+ CS+ CG+G R+R+ VK
Sbjct: 712 LTVQPYRCQHLE-------KPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRD--VK 762
Query: 530 QFPEDGSVCTLPTEETEKCTVN------EECSPSSC----LMTEWGEWDECSATCGMGMK 579
G V + E+C + E C C +TEW E CSA CG G++
Sbjct: 763 CVSNIGDVV-----DDEECNMKLRPNDIENCDMGPCAKSWFLTEWSE--RCSAECGAGVR 815
Query: 580 KRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLS-PW--SEWSDCSVTCGKGMRT 636
R + N + + P C PC W WS CS+ CG G T
Sbjct: 816 TRSVVCMTNHVSSLPLEGCGNNRPAEATP-CDNGPCTGKVEWFAGSWSQCSIECGSG--T 872
Query: 637 RQRMLKSLAELGDCNEDLEQVEKCMLPECPID--CEL----TEW--SQWSECNKSCGKGH 688
+QR + + + D E L+ E L + P C L +W ++WS C+KSC G
Sbjct: 873 QQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGF 932
Query: 689 VIR 691
+R
Sbjct: 933 RVR 935
Score = 73.6 bits (179), Expect = 7e-13
Identities = 77/271 (28%), Positives = 113/271 (41%), Gaps = 34/271 (12%)
Query: 435 DEDDTPETC---IYSNW---SPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQP 488
++ +T TC I S W + W++CS C G+R R +K ++ D +
Sbjct: 723 EKPETTSTCQLKICSEWQIRTDWTSCSVP-CGVGQRTRD--VKCVSNIGDVVDDEECNMK 779
Query: 489 CMGPGCSDEDGSTCTMSEWIT-WSP-CSISCGMGMRSRE-----RYVKQFPEDGSVCTLP 541
+ D C S ++T WS CS CG G+R+R +V P +G P
Sbjct: 780 LRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRP 839
Query: 542 TEETEKCTVNEECSPSSCL-MTEW--GEWDECSATCGMGMKKRHRMIKMNPADGS--MCK 596
E T C C EW G W +CS CG G ++R + AD +
Sbjct: 840 AEATP-------CDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDP 892
Query: 597 AETSQAEKCMMPE-CHTIPCLLSPWS-EWSDCSVTCGKGMRTRQ-RMLK---SLAELGDC 650
+E S EK + CH PC +S EWS CS +C G R R+ R L +L+ L D
Sbjct: 893 SECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDP 952
Query: 651 NEDLEQVEKCMLPECPIDCELTEWSQWSECN 681
E+ E C +C + + ++ CN
Sbjct: 953 QLKPEERESCNPQDCVPEVDENCKDKYYNCN 983
Score = 63.5 bits (153), Expect = 7e-10
Identities = 65/256 (25%), Positives = 101/256 (39%), Gaps = 50/256 (19%)
Query: 569 ECSATCGMGMK-KRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSP----W--S 621
ECS TCG G + R + + + +A S + M P PC + P W
Sbjct: 628 ECSTTCGKGSQYPIFRCVHRSTHE----EAPESYCDSSMKPTPEEEPCNIFPCPAFWDIG 683
Query: 622 EWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCEL---TEW---S 675
EWS+CS TCG GM+ RQ + + + + + PE C+L +EW +
Sbjct: 684 EWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRT 743
Query: 676 QWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREAR 735
W+ C+ CG G RTR ++ G + V ++C ++ LR I+
Sbjct: 744 DWTSCSVPCGVGQ--RTRDVKCVSNIG-----DVVDDEECNMK--LRPNDIENC------ 788
Query: 736 ESRRSEQLKEESEGEQFPGCRMRPWTAWSE-CTKLCGGGIQERYMTVKKRFKSS-QFTSC 793
+ P + T WSE C+ CG G++ R + SS C
Sbjct: 789 --------------DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGC 834
Query: 794 KDKK--EIRACNVHPC 807
+ + E C+ PC
Sbjct: 835 GNNRPAEATPCDNGPC 850
Score = 54.3 bits (129), Expect = 4e-07
Identities = 54/206 (26%), Positives = 81/206 (39%), Gaps = 20/206 (9%)
Query: 421 NVDDIVADLAPEEKDEDDTPETC----IYSNW--SPWSACSSSTCDKGKRMRQRMLKAQL 474
N+ D+V D K + E C +W + WS S+ C G R R +
Sbjct: 766 NIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNH 825
Query: 475 DLSVPCPDTQDFQPCMGPGCSDEDGSTCTMS-EWI--TWSPCSISCGMGMRSRERYVKQF 531
S+P + +P C D CT EW +WS CSI CG G + RE +
Sbjct: 826 VSSLPLEGCGNNRPAEATPC---DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRK 882
Query: 532 PEDGSVCTLPTEET--EKCTVNEECSPSSCLMTEW--GEWDECSATCGMGMKKRH-RMIK 586
D P+E + EK + C C +W EW CS +C G + R R +
Sbjct: 883 NADTFEVLDPSECSFLEKPPSQQSCHLKPC-GAKWFSTEWSMCSKSCQGGFRVREVRCLS 941
Query: 587 MNPADGSMC--KAETSQAEKCMMPEC 610
+ ++C + + + E C +C
Sbjct: 942 DDMTLSNLCDPQLKPEERESCNPQDC 967
Score = 30.8 bits (68), Expect = 5.2
Identities = 14/46 (30%), Positives = 22/46 (47%), Gaps = 1/46 (2%)
Query: 732 REARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQER 777
R+ + +E E+ G PG W WS C++ C GG+ E+
Sbjct: 32 RKVPQRMAAEGAPEDDGGGGAPGV-WGAWGPWSACSRSCSGGVMEQ 76
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 92.4 bits (228), Expect = 1e-18
Identities = 89/410 (21%), Positives = 152/410 (37%), Gaps = 60/410 (14%)
Query: 443 CIYSNW--SPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGS 500
C+++ W S WS CS S C G+R R+ + + Q+ C++
Sbjct: 965 CVFTRWHYSEWSQCSRS-CGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCP 1023
Query: 501 TCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSS-- 558
+ SEW S C ++CG G + R+ + C L + N P S
Sbjct: 1024 SWAASEW---SECLVTCGKGTKQRQVW----------CQLNVDHLSDGFCNSSTKPESLS 1070
Query: 559 ------CLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEK------CM 606
C + G W C+ TCG G + R A + E +A + C+
Sbjct: 1071 PCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCV 1130
Query: 607 MPECHTIPCL------------LSPW--SEWSDCSVTCGKGMRTRQRMLK-SLAELGDCN 651
+ C I L ++ W W+ CSV+CG+G + R + +L + D +
Sbjct: 1131 LTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADES 1190
Query: 652 EDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIR--TRMIQMEPQFGGAPCPET 709
+ +C C + WS C+ SCG G R M +P PE
Sbjct: 1191 YCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEV 1250
Query: 710 --VQRKKCRIRKC------LRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWT 761
+ ++C + C + +Q + + +++L++ P R W
Sbjct: 1251 RPLMEQECSLAACPPAHSHFPSSPVQP-SYYLSTNLPLTQKLEDNENQVVHPSVRGNQWR 1309
Query: 762 A--WSECTKLCGGGIQERYMTVK-KRFKSSQFTSCKDK-KEIRACNVHPC 807
W C+ C GG+Q R + + + +S+ + K E++ C PC
Sbjct: 1310 TGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC 1359
Score = 83.6 bits (205), Expect = 7e-16
Identities = 94/396 (23%), Positives = 140/396 (35%), Gaps = 129/396 (32%)
Query: 451 WSACSSSTCDKGKRMRQRMLKAQLD----------LSVPCPDTQDFQPCMGPGCSDEDGS 500
W+ CS S C +G + R + LD L P F PC
Sbjct: 1161 WTPCSVS-CGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPC----------- 1208
Query: 501 TCTMSEWIT--WSPCSISCGMGMRSRERYVKQF--PEDGSVCTLPTEETEKCTVNEECSP 556
EW WSPCS SCG G +R+ + P D + C + + + +ECS
Sbjct: 1209 ----GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC----DPEVRPLMEQECSL 1260
Query: 557 SSC-----------------LMT-----------------------EW--GEWDECSATC 574
++C L T +W G W CS++C
Sbjct: 1261 AACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC 1320
Query: 575 GMGMKKRHRMIKMNPADG---SMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCG 631
G++ HR + +G S C A + E + +C PC + W +CS TCG
Sbjct: 1321 SGGLQ--HRAVVCQDENGQSASYCDAASKPPE---LQQCGPGPCPQWNYGNWGECSQTCG 1375
Query: 632 KGMRTRQRMLK----SLAELGDCN--EDLEQVEKCMLPECPIDCELTEWSQ--WSECNKS 683
G+++R + + + E +C V +C + CP D W Q W+ C+ S
Sbjct: 1376 GGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPAD---VSWHQEPWTSCSAS 1432
Query: 684 CGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQL 743
CGKG R C + QRK E Q+
Sbjct: 1433 CGKGRKYREVF-----------CIDQFQRKL---------------------EDTNCSQV 1460
Query: 744 KEESEGEQFPGCRMRPWTA--WSECTKLCGGGIQER 777
++ + R W A W+EC+ CG G+Q+R
Sbjct: 1461 QKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQR 1496
Score = 82.8 bits (203), Expect = 1e-15
Identities = 89/360 (24%), Positives = 136/360 (37%), Gaps = 57/360 (15%)
Query: 448 WSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEW 507
+ PW C+ +G + R + D SV D P P + +T W
Sbjct: 853 YGPWEGCTKMC--QGLQRRNITCIHKSDHSVVSDKECDHLPL--PSFVTQSCNTDCELRW 908
Query: 508 --ITWSPCSISCGMGMRSRERYVKQFP-EDGSVCTLPTE---ETEKCTVNEECSPSSCLM 561
I S CS CG G R+ + + ++ +G + + K E C +C+
Sbjct: 909 HVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCH-GNCVF 967
Query: 562 TEW--GEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSP 619
T W EW +CS +CG G + R MN + E + + C+ C
Sbjct: 968 TRWHYSEWSQCSRSCGGGERSRESYC-MNNFGHRLADNECQELSRVTRENCNEFSCPSWA 1026
Query: 620 WSEWSDCSVTCGKGMRTRQRMLK-SLAELGD--CNEDL--EQVEKCMLPECPIDCELTEW 674
SEWS+C VTCGKG + RQ + ++ L D CN E + C L C W
Sbjct: 1027 ASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC------ASW 1080
Query: 675 --SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCR---IRKCLRNPS--IQ 727
W C +CG G+ +R ++ + A +T + R + C+ P I
Sbjct: 1081 QVGPWGPCTTTCGHGYQMRD--VKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFIS 1138
Query: 728 KLRWREARESRRSEQLKEESEGEQFPGC---RMRPWT--AWSECTKLCGGGIQERYMTVK 782
KL E P +M W +W+ C+ CG G Q RY++ +
Sbjct: 1139 KL------------------ETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCR 1180
Score = 73.9 bits (180), Expect = 5e-13
Identities = 59/241 (24%), Positives = 102/241 (42%), Gaps = 32/241 (13%)
Query: 505 SEWIT--WSPCSISCGMGMRSRERYVK-QFPEDGSVCTLPTEETEKCTVNEECSPSSCLM 561
++W T W CS SC G++ R + + + S C ++ E ++C P C
Sbjct: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPEL----QQCGPGPCPQ 1361
Query: 562 TEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQA--EKCMMPECHTIPCLLS- 618
+G W ECS TCG G+K R++ +G + + + + + +CH C
Sbjct: 1362 WNYGNWGECSQTCGGGIKS--RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADV 1419
Query: 619 PWSE--WSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEK------CMLPECPIDCE 670
W + W+ CS +CGKG + R+ + + + QV+K C CP
Sbjct: 1420 SWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP---- 1475
Query: 671 LTEW--SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQR--KKCRIRKCLRNPSI 726
W + W+EC+ +CG G ++ R + + G E + + C R+C +
Sbjct: 1476 --SWKANSWNECSVTCGSG--VQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCV 1531
Query: 727 Q 727
Q
Sbjct: 1532 Q 1532
Score = 73.2 bits (178), Expect = 9e-13
Identities = 99/437 (22%), Positives = 150/437 (34%), Gaps = 127/437 (29%)
Query: 449 SPWSACSSSTCDKGKRMRQRMLKAQLD-----LSVPCPDTQDFQPCMGPGCSDEDGSTCT 503
S WS C TC KG + RQ + +D + PC + TC
Sbjct: 1028 SEWSECLV-TCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPC--------ELHTCA 1078
Query: 504 MSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTE--ETEKCTVNEECSPSSCL- 560
+ W PC+ +CG G + R+ VK E S TE E + + + C + C
Sbjct: 1079 SWQVGPWGPCTTTCGHGYQMRD--VKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSF 1136
Query: 561 ----------------MTEW--GEWDECSATCGMGMKKRH---RMIKMNPADGSMCKAET 599
M +W G W CS +CG G + R+ R AD S C
Sbjct: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLP 1196
Query: 600 SQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGD---CNEDLEQ 656
AE + +C T PC +WS CS +CG G TRQ + + + D C+ ++
Sbjct: 1197 RPAE---IWDCFT-PCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRP 1252
Query: 657 V--EKCMLPECP------------------IDCELTE------------------W--SQ 676
+ ++C L CP + LT+ W
Sbjct: 1253 LMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGP 1312
Query: 677 WSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARE 736
W C+ SC G R + Q E + C K +++C P
Sbjct: 1313 WGSCSSSCSGGLQHRAVVCQDENGQSASYCDAA--SKPPELQQCGPGP------------ 1358
Query: 737 SRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFT---SC 793
C + W EC++ CGGGI+ R + +F + Q +C
Sbjct: 1359 ------------------CPQWNYGNWGECSQTCGGGIKSRLVIC--QFPNGQILEDHNC 1398
Query: 794 K---DKKEIRACNVHPC 807
+ + C++H C
Sbjct: 1399 EIVNKPPSVIQCHMHAC 1415
Score = 69.7 bits (169), Expect = 1e-11
Identities = 71/259 (27%), Positives = 106/259 (40%), Gaps = 48/259 (18%)
Query: 450 PWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQ----DFQPCMGPGCSDEDGSTCTMS 505
PW +CSSS C G + R + + + S D + Q C GPG C
Sbjct: 1312 PWGSCSSS-CSGGLQHRAVVCQDENGQSASYCDAASKPPELQQC-GPG-------PCPQW 1362
Query: 506 EWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKC-TVNEECSPSSCLM--- 561
+ W CS +CG G++SR + QFP +G + E C VN+ S C M
Sbjct: 1363 NYGNWGECSQTCGGGIKSR-LVICQFP-NGQIL-----EDHNCEIVNKPPSVIQCHMHAC 1415
Query: 562 ---TEWGE--WDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMP----ECHT 612
W + W CSA+CG G K R ++ D K E + + P C +
Sbjct: 1416 PADVSWHQEPWTSCSASCGKGRKYR----EVFCIDQFQRKLEDTNCSQVQKPPTHKACRS 1471
Query: 613 IPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDL--EQVEKCMLPECPIDCE 670
+ C + W++CSVTCG G++ R + L +G E++ + C C
Sbjct: 1472 VRCPSWKANSWNECSVTCGSGVQQRDVYCR-LKGVGQVVEEMCDQSTRPCSQRRC----- 1525
Query: 671 LTEWSQWSECNKSCGKGHV 689
WSQ +K +G +
Sbjct: 1526 ---WSQDCVQHKGMERGRL 1541
Score = 41.2 bits (95), Expect = 0.004
Identities = 28/112 (25%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 511 SPCSISCGMGMRSRERYVKQFP--EDGSVCTLPTEETEKCTVNEECSPSSCL-----MTE 563
S C+ +CG R R Y + P + + L ++C V C+ +
Sbjct: 1598 SQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLAT 1657
Query: 564 W--GEWDECSATCGMG-MKKRHRMIKMNPADGSMC--KAETSQAEKCMMPEC 610
W G+W +CS TCG+G MK++ + I + +C + +KC +C
Sbjct: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 40.4 bits (93), Expect = 0.007
Identities = 60/265 (22%), Positives = 101/265 (38%), Gaps = 48/265 (18%)
Query: 451 WSACSSSTCDKGKRMRQRMLKAQ-LDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWIT 509
W+ CS TC G + R + + + V Q +PC C +D C + +
Sbjct: 1482 WNECSV-TCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQD---CVQHKGME 1537
Query: 510 WSP--CSISCG-----MGMRSRERYVKQFPE---DGSVCTLPTEETEKCTVNEECSPSSC 559
CS SC M + ++Q E + S +L T K N C+
Sbjct: 1538 RGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISL----TSKNCRNPPCN---- 1589
Query: 560 LMTEWGEWDECSATCGMGMK------------KRHRMIKMNPADGSMCKA-ETSQAEKCM 606
+ + +C+ CG + K+H++ ++ P C +SQ +C+
Sbjct: 1590 YIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
Query: 607 MPECHTIPCLLSPWS--EWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPE 664
H L+ W +WS CSVTCG G+ RQ +K + + G + DL + P
Sbjct: 1650 NSCLH-----LATWKVGKWSKCSVTCGIGIMKRQ--VKCITKHG-LSSDL--CLNHLKPG 1699
Query: 665 CPIDCELTEWSQWSECNKSCGKGHV 689
C + ++ C + K H+
Sbjct: 1700 AQKKCYANDCKSFTTCKEIQVKNHI 1724
Score = 33.9 bits (76), Expect = 0.62
Identities = 14/50 (28%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 759 PWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKK-EIRACNVHPC 807
PW +S C++ CGGGI+ + + C ++ + R+CN C
Sbjct: 561 PWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
Score = 33.5 bits (75), Expect = 0.81
Identities = 42/175 (24%), Positives = 67/175 (38%), Gaps = 41/175 (23%)
Query: 434 KDEDDTPETCIYSNWSPWSACSSSTCDKG-----KRMRQ------------RMLKAQLDL 476
K+ + P + W P+S+C S TC G +R + R +K +
Sbjct: 548 KETETRPVNGEWGPWEPYSSC-SRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCN 606
Query: 477 SVPCP-DTQDFQPCMGPGCSDEDGSTCTMS---EWITWSP----------CSISCGMGMR 522
+ CP TQDF+ CSD +G +S + W P C + C +
Sbjct: 607 TDSCPKGTQDFRE---KQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGT 663
Query: 523 SRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSC--LMTEWGEWDECSATCG 575
+ +K EDG+ C ET V +C + C ++ + D+C CG
Sbjct: 664 NYFYLLKDMVEDGTPC---GTETHDICVQGQCMAAGCDHVLNSSAKIDKC-GVCG 714
Score = 32.0 bits (71), Expect = 2.4
Identities = 41/165 (24%), Positives = 64/165 (38%), Gaps = 50/165 (30%)
Query: 504 MSEWITWSPCSISCGMGMRSRERYVKQFPEDG-----------SVCTLPTE-------ET 545
MS W +WS CS +YV +F + G + LP+E
Sbjct: 438 MSPW-SWSNCS----------RKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGN 486
Query: 546 EKCTV-----NEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMI---KMNPADGSMC-K 596
++C + ++ C + M W C++T +K H+ + PADG+ C
Sbjct: 487 KQCELAFGPGSQMCPHINICMHLW-----CTST-----EKLHKGCFTQHVPPADGTDCGP 536
Query: 597 AETSQAEKCMMPECHTIPCL--LSPWSEWSDCSVTCGKGMRTRQR 639
+ C+ E T P PW +S CS TCG G+ + R
Sbjct: 537 GMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATR 581
Score = 31.6 bits (70), Expect = 3.1
Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 666 PIDCELTEWSQWSECNKSCGKGHVIRTRMI-QMEPQFGGAPC-PETVQRKKCRIRKC 720
P++ E W +S C+++CG G TR + EP+ GG C ++ + C C
Sbjct: 554 PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 90.5 bits (223), Expect = 6e-18
Identities = 91/321 (28%), Positives = 134/321 (41%), Gaps = 44/321 (13%)
Query: 508 ITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEW--G 565
I S CS+SCG G + + + + + +T+ T + C+ SC W G
Sbjct: 880 IVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSC-PAYWMPG 938
Query: 566 EWDECSATCGMGMKKRH-RMIKMNPADG------SMCKAET-SQAEKCMMPECHTIPCLL 617
EW CS C G + R + ++ P S+C T +Q + C H P
Sbjct: 939 EWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQAC---NSHACP--- 992
Query: 618 SPWS--EWSDCSVTCGKGMRTRQRMLK-SLAEL---GDCNE--DLEQVEKCMLPECPIDC 669
WS WS CS TCG+G+R R+ + K S AE C E E C+L CP +
Sbjct: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNS 1052
Query: 670 ELTEW--SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQ 727
L +W S WSEC+ +CG G V + M E F G T ++CR ++ P++
Sbjct: 1053 RL-QWVASSWSECSATCGLG-VRKREMKCSEKGFQGKLI--TFPERRCR---NIKKPNL- 1104
Query: 728 KLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKS 787
+ E+ G P W +CT CGGG+Q R + ++ +
Sbjct: 1105 -----DLEETCNRRACPAHPVYNMVAGWYSLP---WQQCTVTCGGGVQTRSVHCVQQGRP 1156
Query: 788 SQFTSCKDKKEI-RACNVHPC 807
S K + RACN + C
Sbjct: 1157 SSSCLLHQKPPVLRACNTNFC 1177
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/224 (29%), Positives = 89/224 (39%), Gaps = 46/224 (20%)
Query: 448 WSP--WSACSSSTCDKGKRMRQ---------RMLKAQLDLSVPCPDTQDFQPCMGPGCSD 496
W P WS CS + C G++ R+ + +A L P Q C C
Sbjct: 935 WMPGEWSTCSKA-CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPP 993
Query: 497 EDGSTCTMSEWIT--WSPCSISCGMGMRSRERYVK-----QFPEDGSVCT-LPTEETEKC 548
+ W WS CS +CG G+R RE K PE S CT LP E ++
Sbjct: 994 Q---------WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPE--SQCTSLPRPELQEG 1042
Query: 549 TVNEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMC-----------KA 597
V C +S L W ECSATCG+G++KR G + K
Sbjct: 1043 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP 1102
Query: 598 ETSQAEKCMMPEC--HTIPCLLSPWSE--WSDCSVTCGKGMRTR 637
E C C H + +++ W W C+VTCG G++TR
Sbjct: 1103 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTR 1146
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/96 (31%), Positives = 42/96 (43%), Gaps = 17/96 (17%)
Query: 630 CGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHV 689
CG M RQ ELG PI + + WS+WSEC+++CG G
Sbjct: 566 CGLSMWCRQGQCVKFGELGPR---------------PIHGQWSAWSKWSECSRTCGGGVK 610
Query: 690 IRTRMI-QMEPQFGGAPCPETVQ-RKKCRIRKCLRN 723
+ R +PQ+GG CP + + + C I C N
Sbjct: 611 FQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN 646
Score = 40.8 bits (94), Expect = 0.005
Identities = 20/51 (39%), Positives = 28/51 (54%), Gaps = 5/51 (9%)
Query: 760 WTAWSECTKLCGGGI--QERYMTVKKRFKSSQFTSCKDKKEI-RACNVHPC 807
W+ WSEC++ CGGG+ QER+ K F C I + CN++PC
Sbjct: 595 WSKWSECSRTCGGGVKFQERHCNNPKPQYGGLF--CPGSSRIYQLCNINPC 643
Score = 35.4 bits (80), Expect = 0.21
Identities = 21/87 (24%), Positives = 33/87 (37%), Gaps = 15/87 (17%)
Query: 540 LPTEETEKCTVNEECSPSSCLM-------------TEWGEWDECSATCGMGMK--KRHRM 584
+P E C ++ C C+ + W +W ECS TCG G+K +RH
Sbjct: 558 MPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCN 617
Query: 585 IKMNPADGSMCKAETSQAEKCMMPECH 611
G C + + C + C+
Sbjct: 618 NPKPQYGGLFCPGSSRIYQLCNINPCN 644
Score = 35.0 bits (79), Expect = 0.28
Identities = 12/22 (54%), Positives = 18/22 (81%)
Query: 618 SPWSEWSDCSVTCGKGMRTRQR 639
S WS+WS+CS TCG G++ ++R
Sbjct: 593 SAWSKWSECSRTCGGGVKFQER 614
Score = 32.0 bits (71), Expect = 2.4
Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 505 SEWITWSPCSISCGMGMRSRERYVKQ-FPEDGSV-CTLPTEETEKCTVNEECSPSS 558
S W WS CS +CG G++ +ER+ P+ G + C + + C +N C+ +S
Sbjct: 593 SAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNIN-PCNENS 647
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 82.8 bits (203), Expect = 1e-15
Identities = 90/311 (28%), Positives = 122/311 (39%), Gaps = 69/311 (22%)
Query: 452 SACSSSTCDKGKRMRQ---RMLKAQLDLSVPCPDTQDFQ---PCMGPGCSDEDGSTCTMS 505
S CS S +R+ R LK Q+++S P T+ PC C
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPS-------- 930
Query: 506 EWIT--WSPCSISCGMGMRSR------ERYVKQFPEDGSVCTLPTEETEKCTVNEECSPS 557
W WS CS +CG G +SR + P S+C P + + ++ C P+
Sbjct: 931 -WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPA 989
Query: 558 SCLMTEW--GEWDECSATCGMGMKKRHRMIKM-NPA------DGSMCKAETSQA--EKCM 606
W G W ECS TCG G +KR K NP+ ++C +E E C+
Sbjct: 990 ------WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACL 1043
Query: 607 MPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLK--------SLAELGD--CNE---- 652
+ CH L S WS CSVTC +G T++R LK EL C+
Sbjct: 1044 LQRCHKPKKLQWLVSAWSQCSVTCERG--TQKRFLKCAEKYVSGKYRELASKKCSHLPKP 1101
Query: 653 DLEQVEKCMLPECPIDCELT-------EW--SQWSECNKSCGKGHVIRTRMIQMEPQFGG 703
LE C CP W S WS+C SCG G ++TR +Q GG
Sbjct: 1102 SLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGG--VQTRSVQC--LAGG 1157
Query: 704 APCPETVQRKK 714
P + +K
Sbjct: 1158 RPASGCLLHQK 1168
Score = 79.7 bits (195), Expect = 1e-14
Identities = 93/333 (27%), Positives = 131/333 (39%), Gaps = 59/333 (17%)
Query: 509 TW----SPCSISCGMG-MRSRERYVK--QFPEDGSVC---TLPTEETEKCTVNEECSPSS 558
TW S CS+SCG G M RE + +F + S C T P C V+ C PS
Sbjct: 873 TWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVS-ACPPSW 931
Query: 559 CLMTEWGEWDECSATCGMGMKKR----HRMIKMN--PADGSMC-KAETSQAEKCMMPECH 611
+ G W CS TCG G + R R + + P S+C + S + C C
Sbjct: 932 SV----GNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCP 987
Query: 612 TIPCLLSPWS--EWSDCSVTCGKGMRTRQRMLKS--------LAELGDCNEDLE--QVEK 659
WS W++CS TCGKG R R KS L C + + E
Sbjct: 988 ------PAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEA 1041
Query: 660 CMLPECPIDCELTEW--SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRI 717
C+L C +L +W S WS+C+ +C +G + R ++ ++ E +K +
Sbjct: 1042 CLLQRCHKPKKL-QWLVSAWSQCSVTCERG--TQKRFLKCAEKYVSGKYRELASKKCSHL 1098
Query: 718 RKCLRNPSIQKLRWREARESRRSEQLKE--ESEGEQFPGCRMRPWTAWSECTKLCGGGIQ 775
K PS++ R R S G F + WS+CT CGGG+Q
Sbjct: 1099 PK----PSLELERACAPLPCPRHPPFAAAGPSRGSWFA-------SPWSQCTASCGGGVQ 1147
Query: 776 ERYMTVKKRFKSSQFTSCKDKKEIR-ACNVHPC 807
R + + + K ACN H C
Sbjct: 1148 TRSVQCLAGGRPASGCLLHQKPSASLACNTHFC 1180
Score = 39.7 bits (91), Expect = 0.011
Identities = 20/54 (37%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 672 TEWSQWSECNKSCGKGHVIRTRM-IQMEPQFGGAPCP-ETVQRKKCRIRKCLRN 723
++WS WS C+++CG G R+R+ +P GG C T K C +KC R+
Sbjct: 590 SDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRD 643
Score = 37.7 bits (86), Expect = 0.043
Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 4/63 (6%)
Query: 551 NEECSPSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPA---DGSMCKAETSQAEKCMM 607
+E P+ ++W W CS TCG G+ R R+ NP G C+ T + C
Sbjct: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLC-TNPKPSHGGKFCEGSTRTLKLCNS 637
Query: 608 PEC 610
+C
Sbjct: 638 QKC 640
Score = 36.2 bits (82), Expect = 0.12
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 3/73 (4%)
Query: 618 SPWSEWSDCSVTCGKGMRTRQRMLKSLAELGD---CNEDLEQVEKCMLPECPIDCELTEW 674
S WS WS CS TCG G+ R R+ + C ++ C +CP D
Sbjct: 590 SDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRA 649
Query: 675 SQWSECNKSCGKG 687
+Q +E N +G
Sbjct: 650 AQCAEHNSRRFRG 662
Score = 35.4 bits (80), Expect = 0.21
Identities = 18/71 (25%), Positives = 30/71 (42%), Gaps = 1/71 (1%)
Query: 738 RRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCK-DK 796
R + +K EG + W++WS C++ CGGG+ R S C+
Sbjct: 570 RGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGST 629
Query: 797 KEIRACNVHPC 807
+ ++ CN C
Sbjct: 630 RTLKLCNSQKC 640
Score = 35.0 bits (79), Expect = 0.28
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 9/52 (17%)
Query: 505 SEWITWSPCSISCGMGMRSRERYVKQFPE--------DGSVCTLPTEETEKC 548
S+W +WSPCS +CG G+ R R P+ +GS TL ++KC
Sbjct: 590 SDWSSWSPCSRTCGGGVSHRSRLCTN-PKPSHGGKFCEGSTRTLKLCNSQKC 640
Score = 30.8 bits (68), Expect = 5.2
Identities = 29/125 (23%), Positives = 44/125 (35%), Gaps = 18/125 (14%)
Query: 449 SPWSACSSSTCDKGKRMR------------QRMLKAQLDLSVPCPDTQDFQPCMGPGCSD 496
S WS CS TC++G + R R L ++ +P P + + C C
Sbjct: 1058 SAWSQCSV-TCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPR 1116
Query: 497 EDGSTC---TMSEWIT--WSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVN 551
+ W WS C+ SCG G+++R S C L + + N
Sbjct: 1117 HPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACN 1176
Query: 552 EECSP 556
P
Sbjct: 1177 THFCP 1181
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 82.4 bits (202), Expect = 2e-15
Identities = 64/223 (28%), Positives = 98/223 (43%), Gaps = 21/223 (9%)
Query: 425 IVADLAPEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQ 484
I +D PE + PE + W C + TC G+R + ++ D +
Sbjct: 899 IPSDPLPENQSSK-APEPLFMWTHTSWEDCDA-TCGGGERKTTVSCTKIMSKNISIVDNE 956
Query: 485 DFQPCMGPG-----CSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCT 539
+ P C+++ T M W+PCS +CG GM+SR+ Q +G++
Sbjct: 957 KCKYLTKPEPQIRKCNEQPCQTRWMMT--EWTPCSRTCGKGMQSRQVACTQQLSNGTLIR 1014
Query: 540 LPTEET--EKCTVNEECSPSSCLMTEW--GEWDECSATCGMGMKKRHRMIKM-NPADGSM 594
+ K + C C MT W G W ECS CG G+ RHR ++ NP +
Sbjct: 1015 ARERDCIGPKPASAQRCEGQDC-MTVWEAGVWSECSVKCGKGI--RHRTVRCTNPRKKCV 1071
Query: 595 CKAETSQAEKCMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTR 637
+AE C E ++ C + +WS CS+TCGKGM++R
Sbjct: 1072 LSTRPREAEDC---EDYS-KCYVWRMGDWSKCSITCGKGMQSR 1110
Score = 80.9 bits (198), Expect = 4e-15
Identities = 72/276 (26%), Positives = 107/276 (38%), Gaps = 67/276 (24%)
Query: 555 SPSSCLMTEWGEWDECSATCGMGMKKRH----RMIKMNPA--DGSMCKAETS---QAEKC 605
+P M W++C ATCG G +K +++ N + D CK T Q KC
Sbjct: 912 APEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKC 971
Query: 606 MMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELG--------DC-NEDLEQ 656
C T + +EW+ CS TCGKGM++RQ G DC
Sbjct: 972 NEQPCQTRWMM----TEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPAS 1027
Query: 657 VEKCMLPECPIDCELTEWSQ--WSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKK 714
++C +C +T W WSEC+ CGKG IR R ++ T RKK
Sbjct: 1028 AQRCEGQDC-----MTVWEAGVWSECSVKCGKG--IRHRTVRC-----------TNPRKK 1069
Query: 715 CRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGI 774
C + S + +E + E + C + WS+C+ CG G+
Sbjct: 1070 CVL----------------------STRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGM 1107
Query: 775 QERYMTVKKRFKSSQFTSCKDKKE---IRACNVHPC 807
Q R + + C ++ R C++ PC
Sbjct: 1108 QSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 68.9 bits (167), Expect = 2e-11
Identities = 54/172 (31%), Positives = 73/172 (42%), Gaps = 20/172 (11%)
Query: 451 WSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDE---DGSTC-TMSE 506
W+ CS TC KG + RQ QL + + C+GP + +G C T+ E
Sbjct: 985 WTPCSR-TCGKGMQSRQVACTQQLSNGTLIRARE--RDCIGPKPASAQRCEGQDCMTVWE 1041
Query: 507 WITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSP-SSCLMTEWG 565
WS CS+ CG G+R R + C L T E E+C S C + G
Sbjct: 1042 AGVWSECSVKCGKGIRHR---TVRCTNPRKKCVLSTRPREA----EDCEDYSKCYVWRMG 1094
Query: 566 EWDECSATCGMGMKKR--HRMIKMNPADGSMCKAETSQAEKCMMPECHTIPC 615
+W +CS TCG GM+ R M K+ G+ C S + CH PC
Sbjct: 1095 DWSKCSITCGKGMQSRVIQCMHKITGRHGNEC---FSSEKPAAYRPCHLQPC 1143
Score = 49.3 bits (116), Expect = 1e-05
Identities = 55/237 (23%), Positives = 91/237 (38%), Gaps = 32/237 (13%)
Query: 492 PGCSDEDGSTCTMSEWI--------TWSPCS---ISCGMGMRSRERYVKQFPEDGSVCTL 540
P C+D G EWI +WS CS + + ++ ++ P+ + +
Sbjct: 497 PSCAD--GLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMV 554
Query: 541 PTEETEKC-TVNEECS----PSSCLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMC 595
P++ T +E+C P + E C + +K R P DG+ C
Sbjct: 555 PSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDC 614
Query: 596 KAETSQAEKCMMPECHTIPC----LLSPWSEWSDCSVTCGKGMRTRQRMLKSL-AELGDC 650
+ C EC + L WS WS CS TC G+ +R+R L +E DC
Sbjct: 615 DL----GKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDC 670
Query: 651 NEDLEQVEKCMLPECPIDCE-LTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPC 706
N +Q C P CP +W + ++ H+++ + + E + PC
Sbjct: 671 NGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEK----PC 723
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/351 (21%), Positives = 116/351 (33%), Gaps = 61/351 (17%)
Query: 506 EWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEWG 565
EW WSPCS +C G+ SRER + C P ++ C N C +W
Sbjct: 638 EWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICE-NPPCPAGLPGFRDWQ 696
Query: 566 ---------------EW----DE---CSATCGMGMKKRHRMIKMNPADGSMCKAETSQAE 603
+W DE C+ C K++ ++ DG+ C + +
Sbjct: 697 CQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQ--GLD 754
Query: 604 KCMMPECHTIPC--LLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCN--EDLEQVEK 659
C C + C LL + C V G G +++K GD N VE
Sbjct: 755 ICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSC--KIIK-----GDFNHTRGAGYVEV 807
Query: 660 CMLPECPIDCELTEWSQWSE--CNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRI 717
++P ++ E + GK + I+ F A R+
Sbjct: 808 LVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWE 867
Query: 718 RKCLRNPSIQKLR-----------WREARESRRSEQLKEESEGEQFPGCRMRPWTAWSEC 766
+ + P+ L + S+ L E + M T+W +C
Sbjct: 868 KISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDC 927
Query: 767 TKLCGGG----------IQERYMTVKKRFKSSQFTSCKDKKEIRACNVHPC 807
CGGG I + +++ K T K + +IR CN PC
Sbjct: 928 DATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT--KPEPQIRKCNEQPC 976
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/79 (27%), Positives = 30/79 (37%), Gaps = 12/79 (15%)
Query: 730 RWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQ 789
+W +A E E GE W+ WS C++ C GI R K S+
Sbjct: 618 KWCKAGECTSRTSAPEHLAGE---------WSLWSPCSRTCSAGISSRER--KCPGLDSE 666
Query: 790 FTSCK-DKKEIRACNVHPC 807
C +K+ R C PC
Sbjct: 667 ARDCNGPRKQYRICENPPC 685
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 80.1 bits (196), Expect = 8e-15
Identities = 73/253 (28%), Positives = 110/253 (43%), Gaps = 31/253 (12%)
Query: 431 PEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDF--QP 488
PEE+ P S WS C++ ++ R ++ D + P+T+ +
Sbjct: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRD--IRCSEDEKLCDPNTRPVGEKN 731
Query: 489 CMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETE-K 547
C GP C + T+S+W PCS SCG G R Y K DG V + E K
Sbjct: 732 CTGPPCDRQ----WTVSDW---GPCSGSCGQGRTIRHVYCKT--SDGRVVPESQCQMETK 782
Query: 548 CTVNEECSPSSCLMTEW--GEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKC 605
C +C W +W+ C+ TCG G+KKR ++ M A+G K +T +C
Sbjct: 783 PLAIHPCGDKNC-PAHWLAQDWERCNTTCGRGVKKR-LVLCMELANG---KPQTRSGPEC 837
Query: 606 MM----PE---CHTIPCLLSPWSEWSDCSVTCGKGMRTRQ-RMLKSLAELGDCNEDLEQV 657
+ PE C PC S WS+C+ TCG G+R R + + + C+ ++ V
Sbjct: 838 GLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPV 897
Query: 658 --EKCMLPECPID 668
+ C L CP +
Sbjct: 898 GRQACDLQPCPTE 910
Score = 75.9 bits (185), Expect = 1e-13
Identities = 100/371 (26%), Positives = 144/371 (38%), Gaps = 71/371 (19%)
Query: 492 PGCSDEDGSTCTMSEWITWS--PCSISCGMGMRSRERYVKQFPE---DGSVCTLPT--EE 544
P + S M W S PCS +C G+ S ++ D S C T E
Sbjct: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
Query: 545 TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRH-RMIKM-NPADGSMCKAETSQA 602
+ EC P E W ECS TCG G + R R KM +P S ++ +A
Sbjct: 613 VHEFCAGRECQPR----WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
Query: 603 EKCMMPE----CHTIPCLLSPW--SEWSDCSVTCG-KGMRTRQRMLKSLAELGDCNEDLE 655
+ + PE C P W SEWS+C+ CG + + TR +L D N
Sbjct: 669 AEAVRPEERKTCRN-PACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPV 727
Query: 656 QVEKCMLPECPIDCELTEW--SQWSECNKSCGKGHVIR--------------------TR 693
+ C P C +W S W C+ SCG+G IR T+
Sbjct: 728 GEKNCTGPPCD-----RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETK 782
Query: 694 MIQMEPQFGGAPCPE------------TVQRK-KCRIRKCLRNPSIQKLRWREARESRRS 740
+ + P G CP T R K R+ C+ + K + R E +
Sbjct: 783 PLAIHP-CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELAN-GKPQTRSGPECGLA 840
Query: 741 EQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDK--KE 798
++ EES + P C + WSECTK CG G++ R + K ++ + D K
Sbjct: 841 KKPPEESTCFERP-CFKWYTSPWSECTKTCGVGVRMRDV---KCYQGTDIVRGCDPLVKP 896
Query: 799 I--RACNVHPC 807
+ +AC++ PC
Sbjct: 897 VGRQACDLQPC 907
Score = 40.4 bits (93), Expect = 0.007
Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 7/65 (10%)
Query: 498 DGSTCTMSEWITWSPCSISCGMGMRSRERYV-----KQFPEDGS-VCTLPTEETEKCTVN 551
D + EW W+ CS SCG G+ S+ER+ K P G+ CT ++ + C V
Sbjct: 44 DATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRV- 102
Query: 552 EECSP 556
+EC P
Sbjct: 103 QECPP 107
Score = 35.8 bits (81), Expect = 0.16
Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 8/55 (14%)
Query: 673 EWSQWSECNKSCGKG------HVIRTRMIQMEPQFGGAPCPETVQR-KKCRIRKC 720
EW++W+ C++SCG G H ++ R + P G C T +R + CR+++C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRR-KSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 35.4 bits (80), Expect = 0.21
Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 12/89 (13%)
Query: 620 WSEWSDCSVTCGKGMRTRQR-----MLKSLAELGD--CNEDLEQVEKCMLPECPIDCELT 672
W++W+ CS +CG G+ +++R KS+ G+ C ++ + C + ECP D
Sbjct: 53 WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSF 112
Query: 673 EWSQWSECNKSCGKGHVIRTRMIQMEPQF 701
Q N HV R Q +P +
Sbjct: 113 REEQCVSFN-----SHVYNGRTHQWKPLY 136
Score = 34.7 bits (78), Expect = 0.36
Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 5/53 (9%)
Query: 760 WTAWSECTKLCGGGI--QERYMTVKKRFK---SSQFTSCKDKKEIRACNVHPC 807
WT W+ C++ CGGG+ QER+ ++R T K + C V C
Sbjct: 53 WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 32.3 bits (72), Expect = 1.8
Identities = 16/54 (29%), Positives = 25/54 (46%), Gaps = 6/54 (11%)
Query: 563 EWGEWDECSATCGMGMKKRHRMI-----KMNPADGS-MCKAETSQAEKCMMPEC 610
EW +W CS +CG G+ + R K P G+ C + + + C + EC
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 31.6 bits (70), Expect = 3.1
Identities = 48/201 (23%), Positives = 70/201 (34%), Gaps = 40/201 (19%)
Query: 417 IVPDNVDDIVADLAPEEKD-EDDTPETCIY-SNWSPWSACSSSTCDKGKRMRQRMLKAQL 474
+ D V D +P E T T + W+ W+ACS S C G ++R Q
Sbjct: 20 VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRS-CGGGVTSQERHCLQQR 78
Query: 475 DLSVPCP-------DTQDFQPCMGPGCSDEDGS----TCT----------MSEW------ 507
SVP P ++ +Q C C + S C +W
Sbjct: 79 RKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPD 138
Query: 508 ----ITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSC--LM 561
I+ PC + C R+ V DG+ C L T+ C V+ +C P C ++
Sbjct: 139 DYVHISSKPCDLHCTTVDGQRQLMVP--ARDGTSCKL-TDLRGVC-VSGKCEPIGCDGVL 194
Query: 562 TEWGEWDECSATCGMGMKKRH 582
D+C G G H
Sbjct: 195 FSTHTLDKCGICQGDGSSCTH 215
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 80.1 bits (196), Expect = 8e-15
Identities = 73/253 (28%), Positives = 110/253 (43%), Gaps = 31/253 (12%)
Query: 431 PEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDF--QP 488
PEE+ P S WS C++ ++ R ++ D + P+T+ +
Sbjct: 674 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRD--IRCSEDEKLCDPNTRPVGEKN 731
Query: 489 CMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETE-K 547
C GP C + T+S+W PCS SCG G R Y K DG V + E K
Sbjct: 732 CTGPPCDRQ----WTVSDW---GPCSGSCGQGRTIRHVYCKT--SDGRVVPESQCQMETK 782
Query: 548 CTVNEECSPSSCLMTEW--GEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKC 605
C +C W +W+ C+ TCG G+KKR ++ M A+G K +T +C
Sbjct: 783 PLAIHPCGDKNC-PAHWLAQDWERCNTTCGRGVKKR-LVLCMELANG---KPQTRSGPEC 837
Query: 606 MM----PE---CHTIPCLLSPWSEWSDCSVTCGKGMRTRQ-RMLKSLAELGDCNEDLEQV 657
+ PE C PC S WS+C+ TCG G+R R + + + C+ ++ V
Sbjct: 838 GLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPV 897
Query: 658 --EKCMLPECPID 668
+ C L CP +
Sbjct: 898 GRQACDLQPCPTE 910
Score = 75.9 bits (185), Expect = 1e-13
Identities = 100/371 (26%), Positives = 144/371 (38%), Gaps = 71/371 (19%)
Query: 492 PGCSDEDGSTCTMSEWITWS--PCSISCGMGMRSRERYVKQFPE---DGSVCTLPT--EE 544
P + S M W S PCS +C G+ S ++ D S C T E
Sbjct: 553 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 612
Query: 545 TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRH-RMIKM-NPADGSMCKAETSQA 602
+ EC P E W ECS TCG G + R R KM +P S ++ +A
Sbjct: 613 VHEFCAGRECQPR----WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
Query: 603 EKCMMPE----CHTIPCLLSPW--SEWSDCSVTCG-KGMRTRQRMLKSLAELGDCNEDLE 655
+ + PE C P W SEWS+C+ CG + + TR +L D N
Sbjct: 669 AEAVRPEERKTCRN-PACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPV 727
Query: 656 QVEKCMLPECPIDCELTEW--SQWSECNKSCGKGHVIR--------------------TR 693
+ C P C +W S W C+ SCG+G IR T+
Sbjct: 728 GEKNCTGPPCD-----RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETK 782
Query: 694 MIQMEPQFGGAPCPE------------TVQRK-KCRIRKCLRNPSIQKLRWREARESRRS 740
+ + P G CP T R K R+ C+ + K + R E +
Sbjct: 783 PLAIHP-CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELAN-GKPQTRSGPECGLA 840
Query: 741 EQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDK--KE 798
++ EES + P C + WSECTK CG G++ R + K ++ + D K
Sbjct: 841 KKPPEESTCFERP-CFKWYTSPWSECTKTCGVGVRMRDV---KCYQGTDIVRGCDPLVKP 896
Query: 799 I--RACNVHPC 807
+ +AC++ PC
Sbjct: 897 VGRQACDLQPC 907
Score = 40.4 bits (93), Expect = 0.007
Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 7/65 (10%)
Query: 498 DGSTCTMSEWITWSPCSISCGMGMRSRERYV-----KQFPEDGS-VCTLPTEETEKCTVN 551
D + EW W+ CS SCG G+ S+ER+ K P G+ CT ++ + C V
Sbjct: 44 DATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRV- 102
Query: 552 EECSP 556
+EC P
Sbjct: 103 QECPP 107
Score = 35.8 bits (81), Expect = 0.16
Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 8/55 (14%)
Query: 673 EWSQWSECNKSCGKG------HVIRTRMIQMEPQFGGAPCPETVQR-KKCRIRKC 720
EW++W+ C++SCG G H ++ R + P G C T +R + CR+++C
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRR-KSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 35.4 bits (80), Expect = 0.21
Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 12/89 (13%)
Query: 620 WSEWSDCSVTCGKGMRTRQR-----MLKSLAELGD--CNEDLEQVEKCMLPECPIDCELT 672
W++W+ CS +CG G+ +++R KS+ G+ C ++ + C + ECP D
Sbjct: 53 WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSF 112
Query: 673 EWSQWSECNKSCGKGHVIRTRMIQMEPQF 701
Q N HV R Q +P +
Sbjct: 113 REEQCVSFN-----SHVYNGRTHQWKPLY 136
Score = 34.7 bits (78), Expect = 0.36
Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 5/53 (9%)
Query: 760 WTAWSECTKLCGGGI--QERYMTVKKRFK---SSQFTSCKDKKEIRACNVHPC 807
WT W+ C++ CGGG+ QER+ ++R T K + C V C
Sbjct: 53 WTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 32.3 bits (72), Expect = 1.8
Identities = 16/54 (29%), Positives = 25/54 (46%), Gaps = 6/54 (11%)
Query: 563 EWGEWDECSATCGMGMKKRHRMI-----KMNPADGS-MCKAETSQAEKCMMPEC 610
EW +W CS +CG G+ + R K P G+ C + + + C + EC
Sbjct: 52 EWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQEC 105
Score = 31.6 bits (70), Expect = 3.1
Identities = 48/201 (23%), Positives = 70/201 (34%), Gaps = 40/201 (19%)
Query: 417 IVPDNVDDIVADLAPEEKD-EDDTPETCIY-SNWSPWSACSSSTCDKGKRMRQRMLKAQL 474
+ D V D +P E T T + W+ W+ACS S C G ++R Q
Sbjct: 20 VAGDTVSTGSTDNSPTSNSLEGGTDATAFWWGEWTKWTACSRS-CGGGVTSQERHCLQQR 78
Query: 475 DLSVPCP-------DTQDFQPCMGPGCSDEDGS----TCT----------MSEW------ 507
SVP P ++ +Q C C + S C +W
Sbjct: 79 RKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREEQCVSFNSHVYNGRTHQWKPLYPD 138
Query: 508 ----ITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSC--LM 561
I+ PC + C R+ V DG+ C L T+ C V+ +C P C ++
Sbjct: 139 DYVHISSKPCDLHCTTVDGQRQLMVP--ARDGTSCKL-TDLRGVC-VSGKCEPIGCDGVL 194
Query: 562 TEWGEWDECSATCGMGMKKRH 582
D+C G G H
Sbjct: 195 FSTHTLDKCGICQGDGSSCTH 215
>gi|169174934 PREDICTED: similar to ADAMTS-like 2 [Homo sapiens]
Length = 660
Score = 80.1 bits (196), Expect = 8e-15
Identities = 73/253 (28%), Positives = 110/253 (43%), Gaps = 31/253 (12%)
Query: 431 PEEKDEDDTPETCIYSNWSPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDF--QP 488
PEE+ P S WS C++ ++ R ++ D + P+T+ +
Sbjct: 383 PEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRD--IRCSEDEKLCDPNTRPVGEKN 440
Query: 489 CMGPGCSDEDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETE-K 547
C GP C + T+S+W PCS SCG G R Y K DG V + E K
Sbjct: 441 CTGPPCDRQ----WTVSDW---GPCSGSCGQGRTIRHVYCKT--SDGRVVPESQCQMETK 491
Query: 548 CTVNEECSPSSCLMTEW--GEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKC 605
C +C W +W+ C+ TCG G+KKR ++ M A+G K +T +C
Sbjct: 492 PLAIHPCGDKNC-PAHWLAQDWERCNTTCGRGVKKR-LVLCMELANG---KPQTRSGPEC 546
Query: 606 MM----PE---CHTIPCLLSPWSEWSDCSVTCGKGMRTRQ-RMLKSLAELGDCNEDLEQV 657
+ PE C PC S WS+C+ TCG G+R R + + + C+ ++ V
Sbjct: 547 GLAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPV 606
Query: 658 --EKCMLPECPID 668
+ C L CP +
Sbjct: 607 GRQACDLQPCPTE 619
Score = 75.9 bits (185), Expect = 1e-13
Identities = 100/371 (26%), Positives = 144/371 (38%), Gaps = 71/371 (19%)
Query: 492 PGCSDEDGSTCTMSEWITWS--PCSISCGMGMRSRERYVKQFPE---DGSVCTLPT--EE 544
P + S M W S PCS +C G+ S ++ D S C T E
Sbjct: 262 PKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEP 321
Query: 545 TEKCTVNEECSPSSCLMTEWGEWDECSATCGMGMKKRH-RMIKM-NPADGSMCKAETSQA 602
+ EC P E W ECS TCG G + R R KM +P S ++ +A
Sbjct: 322 VHEFCAGRECQPR----WETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 377
Query: 603 EKCMMPE----CHTIPCLLSPW--SEWSDCSVTCG-KGMRTRQRMLKSLAELGDCNEDLE 655
+ + PE C P W SEWS+C+ CG + + TR +L D N
Sbjct: 378 AEAVRPEERKTCRN-PACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPV 436
Query: 656 QVEKCMLPECPIDCELTEW--SQWSECNKSCGKGHVIR--------------------TR 693
+ C P C +W S W C+ SCG+G IR T+
Sbjct: 437 GEKNCTGPPCD-----RQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETK 491
Query: 694 MIQMEPQFGGAPCPE------------TVQRK-KCRIRKCLRNPSIQKLRWREARESRRS 740
+ + P G CP T R K R+ C+ + K + R E +
Sbjct: 492 PLAIHP-CGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELAN-GKPQTRSGPECGLA 549
Query: 741 EQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDK--KE 798
++ EES + P C + WSECTK CG G++ R + K ++ + D K
Sbjct: 550 KKPPEESTCFERP-CFKWYTSPWSECTKTCGVGVRMRDV---KCYQGTDIVRGCDPLVKP 605
Query: 799 I--RACNVHPC 807
+ +AC++ PC
Sbjct: 606 VGRQACDLQPC 616
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 76.6 bits (187), Expect = 8e-14
Identities = 46/155 (29%), Positives = 74/155 (47%), Gaps = 23/155 (14%)
Query: 510 WSPCSISCGMGMRSRERYVKQFPED---------GSVCTLPTEETEKCTVNEECSPSSCL 560
WSPCS++CG+G+++R+ + +C P T + C P+
Sbjct: 675 WSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPA--- 731
Query: 561 MTEW--GEWDECSATCGMGMKKRHRMIKMNPADGSMCKA-ET--SQAEKCMMPECHTIPC 615
W +W CS TCG G++KR + K ADGS + ET S ++ C C
Sbjct: 732 ---WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDC 788
Query: 616 LLSPW--SEWSDCSVTCGKGMRTRQRMLKSLAELG 648
S W S+W++CS +CG+G +TR + + + + G
Sbjct: 789 P-SEWLLSDWTECSTSCGEGTQTRSAICRKMLKTG 822
Score = 68.9 bits (167), Expect = 2e-11
Identities = 77/327 (23%), Positives = 128/327 (39%), Gaps = 61/327 (18%)
Query: 451 WSACSSSTCDKGKRMRQRMLKAQLDLS-----VPCPDTQDFQP-----CMGPGCSDED-- 498
WSAC+ TC G ++R + L S +P + + +P C CS E
Sbjct: 531 WSACTV-TCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPE 589
Query: 499 ----------GSTCTMSEWITW-----SPCSISCGMGMRSR-----ERYVKQFPEDGSVC 538
G E W + CS SCG G++ + ++ P + ++C
Sbjct: 590 FNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE-PAEENLC 648
Query: 539 TLPTEETEKCTVNEECSPSSC-LMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKA 597
+ + + C+ C E G+W CS TCG+G++ R + + M +
Sbjct: 649 VTSRRPPQ---LLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRD-VFCSHLLSREMNET 704
Query: 598 ETSQAEKCMMPE------CHTIPCLLSPW-SEWSDCSVTCGKGMRTRQRMLKSLAELGDC 650
E C P+ C+ C + + ++W CS TCG G++ R+ + K G
Sbjct: 705 VILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSF 764
Query: 651 NEDLEQVEKCMLPECPIDCEL----TEW--SQWSECNKSCGKGHVIRTRMIQMEPQFGGA 704
E E P C C+ +EW S W+EC+ SCG+G R+ + + + G +
Sbjct: 765 LELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLS 824
Query: 705 ---------PCPETVQRKKCRIRKCLR 722
P P + + C + C R
Sbjct: 825 TVVNSTLCPPLPFSSSIRPCMLATCAR 851
Score = 67.0 bits (162), Expect = 7e-11
Identities = 84/377 (22%), Positives = 144/377 (38%), Gaps = 99/377 (26%)
Query: 512 PCSISCGMG----------MRSR----ERYVKQFPEDGSVCTLPTEETEKCTVNEECSPS 557
PCS +CG G +RS ++Y +PE+ P + ++C + + C S
Sbjct: 308 PCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPEN----IKPKPKLQECNL-DPCPAS 362
Query: 558 SCL-----------MTEWGE--WDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEK 604
+ W W CS++CG G++ R G + E K
Sbjct: 363 DGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW---K 419
Query: 605 CM----MP---ECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAEL--GDCNEDLE 655
CM MP C+ C EWS C+VTCG+G+R R + + G C+ +
Sbjct: 420 CMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTK 479
Query: 656 Q--VEKCMLP--------ECPIDCELTEWSQ--------------------WSECNKSCG 685
E+C++P + P++ +L + Q WS C +CG
Sbjct: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
Query: 686 KGHVIRTRMIQMEPQFGGA----PCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSE 741
G +R Q+ F + P E K R C P ++ E
Sbjct: 540 VGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEI----------PE 589
Query: 742 QLKEESEG-----EQFPGCRMRPWTAWSECTKLCGGGIQERYM------TVKKRFKSSQF 790
+E++G + F + +++C++ CGGG+QE + T + ++
Sbjct: 590 FNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCV 649
Query: 791 TSCKDKKEIRACNVHPC 807
TS + + +++CN+ PC
Sbjct: 650 TSRRPPQLLKSCNLDPC 666
Score = 59.7 bits (143), Expect = 1e-08
Identities = 99/487 (20%), Positives = 164/487 (33%), Gaps = 138/487 (28%)
Query: 411 KGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNW--SPWSACSSSTCDKGKRMRQR 468
K ++CN+ P D + P + W +PW+ACSSS C G + R
Sbjct: 350 KLQECNLDPCPASDGYKQIMPYDLYHP-------LPRWEATPWTACSSS-CGGGIQSRA- 400
Query: 469 MLKAQLDLSVPCPDTQDFQPCMGPGCS-DEDGSTCTMSEWIT--WSPCSISCGMGMRSRE 525
+ + D+ ++++ P + + +W+ WSPC+++CG G+R R
Sbjct: 401 VSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRV 460
Query: 526 RYV-------------KQFPEDGSVCTLPT---EETEKCTVN---------EECSPSSCL 560
K P C +PT + EK V +E + +
Sbjct: 461 VLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAV 520
Query: 561 MTEWG----EWDECSATCGMGMKKR----HRMIKMNPADGSMCKAETSQAEKCMMPECHT 612
E W C+ TCG+G + R ++ + + + E + C+
Sbjct: 521 SEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYA 580
Query: 613 IPCL-----------------------LSPW--SEWSDCSVTCGKGMRTR-----QRMLK 642
PC L W ++ CS +CG G++ + +
Sbjct: 581 GPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTR 640
Query: 643 SLAELGDC---NEDLEQVEKCMLPECPIDCELTEWSQWSECNKSCGKG---------HVI 690
AE C + ++ C L CP E+ +WS C+ +CG G H++
Sbjct: 641 EPAEENLCVTSRRPPQLLKSCNLDPCPARWEI---GKWSPCSLTCGVGLQTRDVFCSHLL 697
Query: 691 RTRM---IQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREARESRRSEQLKEES 747
M + + + P P TVQ C C W A+
Sbjct: 698 SREMNETVILADELCRQPKPSTVQ--ACNRFNC-------PPAWYPAQ------------ 736
Query: 748 EGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQF-----TSCKDKKEI--R 800
W C++ CGGG+Q+R + K+R F T C K +
Sbjct: 737 ---------------WQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQ 781
Query: 801 ACNVHPC 807
AC C
Sbjct: 782 ACKKDDC 788
Score = 51.2 bits (121), Expect = 4e-06
Identities = 48/204 (23%), Positives = 89/204 (43%), Gaps = 26/204 (12%)
Query: 452 SACSSSTCDKG-KRMRQRMLKAQLDLSVPCPDTQDFQPCMGP-GCSDEDGSTCTMSEWI- 508
+ CS+S ++G ++ R R L +++ P +P + P C+ D S W+
Sbjct: 1497 ATCSASCGNRGVQQPRLRCLLNSTEVN-PAHCAGKVRPAVQPIACNRRD----CPSRWMV 1551
Query: 509 -TWSPCSISCGMGMRSRERYVKQF-------PEDGSVCTLPTEETEKCTVNEECSPSSCL 560
+WS C+ SCG G+++R ++ P +C T+ ++ + C+ C+
Sbjct: 1552 TSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMC---TQVAKRPVDTQACNQQLCV 1608
Query: 561 MTEWGEWDECSATC-GMGMKKRHRMIKMNPADGSMCKAETSQA--EKCMMPECHTIPCLL 617
+ W +C+ C G + +HR + DG +E A C + C +
Sbjct: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSV 1668
Query: 618 SPW--SEWSDCSVTCGK-GMRTRQ 638
W S W+ C+ TCG G ++R+
Sbjct: 1669 H-WRVSLWTLCTATCGNYGFQSRR 1691
Score = 40.0 bits (92), Expect = 0.009
Identities = 56/227 (24%), Positives = 89/227 (39%), Gaps = 54/227 (23%)
Query: 570 CSATCGMGMKKRHRM------IKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPW--S 621
CSA+CG ++ R+ ++NPA + Q C +C S W +
Sbjct: 1499 CSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCP------SRWMVT 1552
Query: 622 EWSDCSVTCGKGMRTRQRMLKSLAELG----DCNEDLEQVEKCMLPECPIDCEL-TEW-- 674
WS C+ +CG G++TR+ + L G N+ QV K + + +L EW
Sbjct: 1553 SWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAF 1612
Query: 675 SQWSECNKSCGKGHV-IRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWRE 733
S W +CN C H+ ++ R + + + G T+ ++C L P + W E
Sbjct: 1613 SSWGQCNGPCIGPHLAVQHRQVFCQTRDG-----ITLPSEQC---SALPRPVSTQNCWSE 1664
Query: 734 ARESRRSEQLKEESEGEQFPGCRMRPW--TAWSECTKLCGG-GIQER 777
A C + W + W+ CT CG G Q R
Sbjct: 1665 A--------------------CSVH-WRVSLWTLCTATCGNYGFQSR 1690
Score = 37.0 bits (84), Expect = 0.073
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 11/57 (19%)
Query: 761 TAWSECTKLCGGGIQERYMTVKKRFKSSQFTS----------CKDKKEIRACNVHPC 807
T+WS CT+ CGGG+Q R +T +K K+S ++ K + +ACN C
Sbjct: 1552 TSWSACTRSCGGGVQTRRVTCQK-LKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Score = 34.3 bits (77), Expect = 0.47
Identities = 92/445 (20%), Positives = 151/445 (33%), Gaps = 100/445 (22%)
Query: 430 APEEKDEDDTPETCIYSNWSPWSACSSS----------TCDKGKRMRQRMLKAQLDLSVP 479
A E+D D ++ W PWS CS + C K R ++ + +V
Sbjct: 26 ARSEEDRDG-----LWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVD 80
Query: 480 C-PDTQDF--QPCMGPGCSDEDGSTCTMSEWITWS-----PCSISCGMGMRSRERYVKQF 531
C P+ DF Q C G EW+ S PCS+ C + V+
Sbjct: 81 CPPEAGDFRAQQCSAHNDVKHHGQ---FYEWLPVSNDPDNPCSLKC--QAKGTTLVVELA 135
Query: 532 PE--DGSVCTLPTEETEKC----------------TVNEE----CS--PSSCLMTEWGEW 567
P+ DG+ C TE + C TV E+ C+ S+C +
Sbjct: 136 PKVLDGTRCY--TESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYK 193
Query: 568 DECSAT------CGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLS--- 618
+ SAT + RH + + D + +T Q K T L+
Sbjct: 194 SQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSS 253
Query: 619 -PWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQW 677
+ ++ D + G T ++K + G + ++ + PI E + +
Sbjct: 254 VDFQKFPDKEILRMAGPLTADFIVK-IRNSGSADSTVQ-----FIFYQPIIHRWRE-TDF 306
Query: 678 SECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKC-------LRNPSIQKLR 730
C+ +CG G+ Q A C + + + C P +Q+
Sbjct: 307 FPCSATCGGGY-----------QLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECN 355
Query: 731 WREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQF 790
S +Q+ P PWTA C+ CGGGIQ R ++ +
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTA---CSSSCGGGIQSRAVSCVEEDIQGHV 412
Query: 791 TSCKDKKEI--------RACNVHPC 807
TS ++ K + + CN+ C
Sbjct: 413 TSVEEWKCMYTPKMPIAQPCNIFDC 437
Score = 30.8 bits (68), Expect = 5.2
Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 14/70 (20%)
Query: 436 EDDTPETCIYSNWSPWSACSSSTCDKGKRMR----QRMLKAQLD------LSVPCPDTQD 485
+DD P + S+ W+ CS+S C +G + R ++MLK L L P P +
Sbjct: 785 KDDCPSEWLLSD---WTECSTS-CGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSS 840
Query: 486 FQPCMGPGCS 495
+PCM C+
Sbjct: 841 IRPCMLATCA 850
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 75.9 bits (185), Expect = 1e-13
Identities = 75/289 (25%), Positives = 119/289 (41%), Gaps = 55/289 (19%)
Query: 450 PWSACSSSTCDKGKRMRQRMLK-----AQLDLSVP---C--PDTQDFQPCMGPGCSD--- 496
PWSAC S+TC G ++R+ + Q + +P C P +PC+ C +
Sbjct: 572 PWSAC-STTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPA 630
Query: 497 ---------EDGSTCTMSEWITWSPCSISCGMGMRSR----ERYVKQFPEDGSVCTL--- 540
ED T E+ ++PC+ +C G + Q + S+C +
Sbjct: 631 SRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHR 690
Query: 541 PTEETEKCTVNEECSPSSCLMTEW--GEWDECSATCGMGMKKRHRMIKMNPADGSMCKAE 598
P ++ C E C P W G W CSATCG+G++ R + ++P + E
Sbjct: 691 PPAMSQACN-TEPCPP------RWHVGSWGPCSATCGVGIQTRD-VYCLHPGETPAPPEE 742
Query: 599 TSQAEKCMMPECHTIPCLLSPW--SEWSDCSVTCGKGMRTRQRMLKSLAELG---DCNED 653
+ + C+ C W EW CS TCG G + R+ + L G + +++
Sbjct: 743 CRDEKPHALQACNQFDC-PPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDE 801
Query: 654 LEQVEK------CMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQ 696
L Q K C +CP + WS+C+ SCG G R ++ Q
Sbjct: 802 LCQGPKASSHKSCARTDCPPHLAV---GDWSKCSVSCGVGIQRRKQVCQ 847
Score = 73.9 bits (180), Expect = 5e-13
Identities = 60/201 (29%), Positives = 91/201 (45%), Gaps = 35/201 (17%)
Query: 488 PCMGPGCSDEDGSTCTMSEWI-TWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEET- 545
P M C+ E C + +W PCS +CG+G+++R+ Y E + P EE
Sbjct: 692 PAMSQACNTEP---CPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPA----PPEECR 744
Query: 546 -EKCTVNEECSPSSCLMTEWG--EWDECSATCGMGMKKRHRMIKMNPADGS-------MC 595
EK + C+ C W EW +CS TCG G + R + DGS +C
Sbjct: 745 DEKPHALQACNQFDC-PPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELC 803
Query: 596 KAETSQAEK-CMMPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSLAELGD----- 649
+ + + K C +C P L+ +WS CSV+CG G++ R+++ + LA G
Sbjct: 804 QGPKASSHKSCARTDC---PPHLAV-GDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLS 859
Query: 650 ---CNE--DLEQVEKCMLPEC 665
C + L V C +PEC
Sbjct: 860 EMMCRDLPGLPLVRSCQMPEC 880
Score = 67.8 bits (164), Expect = 4e-11
Identities = 83/377 (22%), Positives = 140/377 (37%), Gaps = 104/377 (27%)
Query: 512 PCSISCGMGMRSR--------------ERYVKQFPEDGSVCTLPTEETEKCTVN------ 551
PC+++CG G + + Y +PE+ P + ++C+++
Sbjct: 350 PCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPEN----VKPKPKLKECSMDPCPSSD 405
Query: 552 --EECSPSSCLMT----EWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKC 605
+E P E W CS +CG G+++R + G + + E KC
Sbjct: 406 GFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEW---KC 462
Query: 606 M-------MPECHTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLKSL--AELGDCNEDLEQ 656
M M C+ C EWS C+VTCG+G+R R + + +G CN L+
Sbjct: 463 MYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKL 522
Query: 657 --VEKCMLP--------ECPIDCELTEWSQ--------------------WSECNKSCGK 686
E+C++P + P++ +L Q WS C+ +CG
Sbjct: 523 HIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGP 582
Query: 687 GHVIR-------TRMIQMEPQFGGAPC--PETVQRKKCRIRKCLRNPSIQKLRWREARES 737
G +R Q E + C P+ + C + C +P+ ++L
Sbjct: 583 GVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASREL-------- 634
Query: 738 RRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTS---C- 793
L E+SE + ++ CT C GG QE + V ++ Q + C
Sbjct: 635 --DIPLPEDSETTY-----DWEYAGFTPCTATCVGGHQEA-IAVCLHIQTQQTVNDSLCD 686
Query: 794 ---KDKKEIRACNVHPC 807
+ +ACN PC
Sbjct: 687 MVHRPPAMSQACNTEPC 703
Score = 63.5 bits (153), Expect = 7e-10
Identities = 82/348 (23%), Positives = 130/348 (37%), Gaps = 90/348 (25%)
Query: 510 WSPCSISCGMGMRSRE----------RYVKQFPEDGSVCTLPTEETEKCTVNEEC--SPS 557
WS CS +CG G++ RE + + PE+ C P TE+ + E C SP+
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEE--ECEGPKLPTERPCLLEACDESPA 630
Query: 558 SCLMT-------------EWGEWDECSATCGMGMKKRHRMI----KMNPADGSMCKAETS 600
S + E+ + C+ATC G ++ + + S+C +
Sbjct: 631 SRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC--DMV 688
Query: 601 QAEKCMMPECHTIPCLLSPW--SEWSDCSVTCGKGMRTRQRML----KSLAELGDC-NED 653
M C+T PC W W CS TCG G++TR ++ A +C +E
Sbjct: 689 HRPPAMSQACNTEPC-PPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEK 747
Query: 654 LEQVEKCMLPECPIDCELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRK 713
++ C +CP + EW Q C+++CG G Q +
Sbjct: 748 PHALQACNQFDCPPGWHIEEWQQ---CSRTCGGG----------------------TQNR 782
Query: 714 KCRIRKCLRNPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMR---PWTA---WSECT 767
+ R+ L + S L S++L + + C P A WS+C+
Sbjct: 783 RVTCRQLLTDGSFLNL----------SDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
Query: 768 KLCGGGIQER-----YMTVKKRFKSSQFTSCKDKKE---IRACNVHPC 807
CG GIQ R + K R C+D +R+C + C
Sbjct: 833 VSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
Score = 61.6 bits (148), Expect = 3e-09
Identities = 63/253 (24%), Positives = 100/253 (39%), Gaps = 52/253 (20%)
Query: 448 WSP--WSACSSSTCDKGKRMRQR---MLKAQLDLSVPCPDTQD----FQPCMGPGCSDED 498
W P WS CS++ G R+++ M Q C Q F+PC C
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP--- 1484
Query: 499 GSTCTMSEWIT--WSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTE---ETEKCTVNEE 553
+ W T WS CS+SCG G SR+ K+ +G+V + ++ +
Sbjct: 1485 ------ARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKP 1538
Query: 554 CSPSSCLMTEWGEWDECSATC---GMGMKKRHRMIKMNPADGSMC--KAETSQAEKCMMP 608
C C+ +W + C C + M++RH + N +D S C + + C
Sbjct: 1539 CFGHPCV--QWEPGNRCPGRCMGRAVRMQQRHTACQHNSSD-SNCDDRKRPTLRRNCTSG 1595
Query: 609 EC----HTIPCLLSPWSEWSDCSVTCGKGMRTRQ------RMLKSLAELGDCNEDLEQV- 657
C HT P W C+ CG+G ++R+ R K +A+ C + + +
Sbjct: 1596 ACDVCWHTGP--------WKPCTAACGRGFQSRKVDCIHTRSCKPVAK-RHCVQKKKPIS 1646
Query: 658 -EKCMLPECPIDC 669
C+ P C DC
Sbjct: 1647 WRHCLGPSCDRDC 1659
Score = 54.3 bits (129), Expect = 4e-07
Identities = 89/422 (21%), Positives = 154/422 (36%), Gaps = 119/422 (28%)
Query: 449 SPWSACSSSTCDKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSE-- 506
+PW+ACS S C G + R+ + + + ++++ P + TC + +
Sbjct: 425 NPWTACSVS-CGGGIQ-RRSFVCVEESMHGEILQVEEWKCMYAP--KPKVMQTCNLFDCP 480
Query: 507 -WIT--WSPCSISCGMGMRSR---------------ERYVKQFPEDGSVCTLPTEETEKC 548
WI WS C+++CG G+R R +K ++ V +P + ++
Sbjct: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
Query: 549 TVNEECSPSSCLMTEWGE--------------WDECSATCGMGMKKRHRMIKMNPADGSM 594
+ E P E E W CS TCG G++ R ++ +
Sbjct: 541 SPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLL---TF 597
Query: 595 CKAETS-QAEKCMMPECHT-IPCLLSPWSE-------------------------WSDCS 627
+ ET E+C P+ T PCLL E ++ C+
Sbjct: 598 TQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCT 657
Query: 628 VTCGKG----------MRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEW--S 675
TC G ++T+Q + SL ++ + Q C CP W
Sbjct: 658 ATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQA--CNTEPCP-----PRWHVG 710
Query: 676 QWSECNKSCGKGHVIRTRMIQ-MEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWREA 734
W C+ +CG G I+TR + + P G P P ++CR
Sbjct: 711 SWGPCSATCGVG--IQTRDVYCLHP--GETPAPP----EECR------------------ 744
Query: 735 RESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCK 794
+ L+ ++ + PG + W +C++ CGGG Q R +T ++ F +
Sbjct: 745 --DEKPHALQACNQFDCPPGWHIE---EWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLS 799
Query: 795 DK 796
D+
Sbjct: 800 DE 801
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/194 (25%), Positives = 71/194 (36%), Gaps = 45/194 (23%)
Query: 623 WSDCSVTCGK-GMRTR--QRMLKSLAELGDC-----NEDLEQVEKCMLPECPIDCELTEW 674
WS CS TCG G R + Q ++ + E+ + + L E C + +CP W
Sbjct: 1433 WSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP-----ARW 1487
Query: 675 --SQWSECNKSCGKGHVIR---------TRMIQMEPQFGGAPCPETVQRKKCRIRKCLR- 722
S WS+C+ SCG+G+ R +Q+ AP + RK C C++
Sbjct: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQW 1547
Query: 723 ---NPSIQKLRWREARESRRSEQLKEESEGEQFPGCRMRP--------------WTA--W 763
N + R R +R + S R RP W W
Sbjct: 1548 EPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDD-RKRPTLRRNCTSGACDVCWHTGPW 1606
Query: 764 SECTKLCGGGIQER 777
CT CG G Q R
Sbjct: 1607 KPCTAACGRGFQSR 1620
Score = 37.4 bits (85), Expect = 0.056
Identities = 26/87 (29%), Positives = 34/87 (39%), Gaps = 6/87 (6%)
Query: 620 WSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSE 679
W +WSDCS TCG G L+ +C + + C +CP D E Q S
Sbjct: 81 WGDWSDCSRTCGGG---ASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSA 137
Query: 680 CNKSCGKGHVIRTRMIQMEPQFGGAPC 706
N +GH +P APC
Sbjct: 138 YNDVQYQGHYYEWLPRYNDP---AAPC 161
Score = 32.7 bits (73), Expect = 1.4
Identities = 14/47 (29%), Positives = 21/47 (44%), Gaps = 4/47 (8%)
Query: 564 WGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPEC 610
WG+W +CS TCG G R G C+ + + + C +C
Sbjct: 81 WGDWSDCSRTCGGGASYSLRRC----LTGRNCEGQNIRYKTCSNHDC 123
Score = 30.4 bits (67), Expect = 6.8
Identities = 14/47 (29%), Positives = 24/47 (51%), Gaps = 6/47 (12%)
Query: 727 QKLRWREARESRRSEQLKEESEGEQFPGCRMRPWTAWSECTKLCGGG 773
Q L +R ++ R+ + E+ +G W WS+C++ CGGG
Sbjct: 54 QFLTYRYDDQTSRNTRSDEDKDGN------WDAWGDWSDCSRTCGGG 94
>gi|27436940 reelin isoform b [Homo sapiens]
Length = 3458
Score = 73.2 bits (178), Expect = 9e-13
Identities = 50/160 (31%), Positives = 78/160 (48%), Gaps = 13/160 (8%)
Query: 44 CSRILRAQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENRE 103
C+ +G +G SL + G+P +Y PG Y VT+S + ++F G + L +
Sbjct: 40 CTHHGELEGDGEQGEVLISLHIAGNPTYYVPGQEYHVTISTS--TFFDGLLVTGLYTSTS 97
Query: 104 GDKEEDHAGT----FQIIDEEE--TQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCV 157
+ G+ F I+ + + QFM C V + + T + WIAPPAGTGCV
Sbjct: 98 VQASQSIGGSSAFGFGIMSDHQFGNQFM--CSVVASHVSHLPTTNLSFIWIAPPAGTGCV 155
Query: 158 ILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPIL 197
A+ + + F+D +L ++LCEQ + D VT P L
Sbjct: 156 NFMATATHRGQVIFKD--ALAQQLCEQGAPTD-VTVHPHL 192
>gi|27436938 reelin isoform a [Homo sapiens]
Length = 3460
Score = 73.2 bits (178), Expect = 9e-13
Identities = 50/160 (31%), Positives = 78/160 (48%), Gaps = 13/160 (8%)
Query: 44 CSRILRAQGTRREGYTEFSLRVEGDPDFYKPGTSYRVTLSAAPPSYFRGFTLIALRENRE 103
C+ +G +G SL + G+P +Y PG Y VT+S + ++F G + L +
Sbjct: 40 CTHHGELEGDGEQGEVLISLHIAGNPTYYVPGQEYHVTISTS--TFFDGLLVTGLYTSTS 97
Query: 104 GDKEEDHAGT----FQIIDEEE--TQFMSNCPVAVTESTPRRRTRIQVFWIAPPAGTGCV 157
+ G+ F I+ + + QFM C V + + T + WIAPPAGTGCV
Sbjct: 98 VQASQSIGGSSAFGFGIMSDHQFGNQFM--CSVVASHVSHLPTTNLSFIWIAPPAGTGCV 155
Query: 158 ILKASIVQKRIIYFQDEGSLTKKLCEQDSTFDGVTDKPIL 197
A+ + + F+D +L ++LCEQ + D VT P L
Sbjct: 156 NFMATATHRGQVIFKD--ALAQQLCEQGAPTD-VTVHPHL 192
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 70.1 bits (170), Expect = 8e-12
Identities = 59/219 (26%), Positives = 89/219 (40%), Gaps = 23/219 (10%)
Query: 510 WSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEW--GEW 567
WS CS +C G++ +E K+ ++ V + K N+ + EW G+W
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDW 908
Query: 568 DECSATCGMGMKKRHRMI--KMNPA-----DGSMCKAETS-QAEKCMMPECHTIPCLLSP 619
ECS TC GM+ R + K+ P+ D S C + E C C L
Sbjct: 909 LECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVAL-- 966
Query: 620 WSEWSDCSVTCGKGMRTRQRMLKS-----LAELGDCNEDLEQVEK--CMLPECPIDCELT 672
+WS+C+ CG G + R + KS C E+ + + C L CP +T
Sbjct: 967 --DWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
Query: 673 EWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQ 711
W +C+ CG G +RT + C ETV+
Sbjct: 1025 --GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVR 1061
Score = 64.7 bits (156), Expect = 3e-10
Identities = 48/175 (27%), Positives = 76/175 (43%), Gaps = 27/175 (15%)
Query: 567 WDECSATCGMGMKKRHRMIKM----NPADGSMCKAETSQAEKCMMPECHTIPCLLSPW-- 620
W ECSATC G++++ + K + + C ++ E C+T PC W
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPEN--QRACNTEPCP-PEWFI 905
Query: 621 SEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCE-------LTE 673
+W +CS TC GMRT R + + ++G E+ C L P++ E +
Sbjct: 906 GDWLECSKTCDGGMRT--RAVLCIRKIGPSEEETLDYSGC-LTHRPVEKEPCNNQSCPPQ 962
Query: 674 W--SQWSECNKSCGKG---HVIRTRMIQMEPQFGGAPCPETVQ---RKKCRIRKC 720
W WSEC CG G ++ + + F A CPE + R +C + +C
Sbjct: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 1017
Score = 60.1 bits (144), Expect = 8e-09
Identities = 59/229 (25%), Positives = 87/229 (37%), Gaps = 17/229 (7%)
Query: 406 ERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNW--SPWSACSSSTCDKGK 463
E + ++ + +IV +N D D P E E C W W CS TCD G
Sbjct: 864 EVVCKRLDDNSIVQNNYCD--PDSKPPENQRACNTEPCP-PEWFIGDWLECSK-TCDGGM 919
Query: 464 RMRQRMLKAQLDLSVPCPDTQDFQPCMG--PGCSDEDGSTCTMSEWIT--WSPCSISCGM 519
R R + ++ S +T D+ C+ P + + +W+ WS C+ CG
Sbjct: 920 RTRAVLCIRKIGPSEE--ETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGP 977
Query: 520 GMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLMTEW--GEWDECSATCGMG 577
G + R K + E K V CS C W G+W +CSA CG+G
Sbjct: 978 GFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLG 1037
Query: 578 MKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWSDC 626
+ R S ET + M +C + C +P S +C
Sbjct: 1038 QQMRTVQCLSYTGQASSDCLETVRPPS--MQQCES-KCDSTPISNTEEC 1083
Score = 52.4 bits (124), Expect = 2e-06
Identities = 48/188 (25%), Positives = 73/188 (38%), Gaps = 45/188 (23%)
Query: 623 WSDCSVTCGKGMRTRQRMLK-----SLAELGDCNEDLEQVEK---CMLPECPIDCELTEW 674
WS+CS TC G++ ++ + K S+ + C+ D + E C CP EW
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP-----PEW 903
Query: 675 --SQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWR 732
W EC+K+C G +RTR + + G + ET+ C + +
Sbjct: 904 FIGDWLECSKTCDGG--MRTRAVLCIRKIGPSE-EETLDYSGCLTHRPVE---------- 950
Query: 733 EARESRRSEQLKEESEGEQFPGCRMRPWTA--WSECTKLCGGGIQERYMTVKKRFKSSQF 790
KE + P W A WSECT CG G + R + K S F
Sbjct: 951 -----------KEPCNNQSCPP----QWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTF 995
Query: 791 TSCKDKKE 798
+ + +E
Sbjct: 996 PAAQCPEE 1003
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/50 (34%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 759 PWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSC-KDKKEIRACNVHPC 807
PW+ W EC++ CGGG+ S C ++K R+CN PC
Sbjct: 563 PWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPC 612
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/88 (27%), Positives = 38/88 (43%), Gaps = 10/88 (11%)
Query: 590 ADGSMCKAETSQAEKCMMPEC-------HTIPCLLSPWSEWSDCSVTCGKGMRTRQRMLK 642
A+G++C+ + C +C +I PWS W +CS TCG G+ + R
Sbjct: 527 AEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCD 586
Query: 643 SLAELGD---CNEDLEQVEKCMLPECPI 667
S A G C + ++ C CP+
Sbjct: 587 SPAPSGGGKYCLGERKRYRSCNTDPCPL 614
Score = 37.0 bits (84), Expect = 0.073
Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 6/51 (11%)
Query: 763 WSECTKLCGGGIQERYMTVKKRFKSS--QFTSC----KDKKEIRACNVHPC 807
WSEC+ C GG+Q + + K+ +S Q C K + RACN PC
Sbjct: 849 WSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
Score = 34.7 bits (78), Expect = 0.36
Identities = 50/192 (26%), Positives = 63/192 (32%), Gaps = 39/192 (20%)
Query: 444 IYSNWSP--WSACS----SSTCDKGKRMRQRMLKAQLDLSVPCPDTQDF-QPCMGPGCSD 496
I +N +P WSACS +S D G+ LD P +DF P + PG
Sbjct: 435 ITANTNPFSWSACSRDYITSFLDSGRG-------TCLDNE---PPKRDFLYPAVAPGQVY 484
Query: 497 EDGSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKC-TVNEE-- 553
+ C T S C G RE + ++P E C T N E
Sbjct: 485 DADEQCRFQYGAT----SRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG 540
Query: 554 -CSPSSCL------------MTEWGEWDECSATCGMGMKK--RHRMIKMNPADGSMCKAE 598
C C+ W W ECS TCG G+ RH G C E
Sbjct: 541 WCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE 600
Query: 599 TSQAEKCMMPEC 610
+ C C
Sbjct: 601 RKRYRSCNTDPC 612
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,729,743
Number of Sequences: 37866
Number of extensions: 1818305
Number of successful extensions: 6332
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 4516
Number of HSP's gapped (non-prelim): 782
length of query: 807
length of database: 18,247,518
effective HSP length: 110
effective length of query: 697
effective length of database: 14,082,258
effective search space: 9815333826
effective search space used: 9815333826
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.