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Search of human proteins with 110227613
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
(911 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 1825 0.0
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 1225 0.0
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 1175 0.0
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 833 0.0
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 801 0.0
gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens] 741 0.0
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 592 e-169
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 573 e-163
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 571 e-163
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 568 e-162
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 566 e-161
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 564 e-160
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 552 e-157
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 551 e-156
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 237 4e-62
gi|7661880 centaurin beta1 [Homo sapiens] 149 1e-35
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 142 2e-33
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 135 2e-31
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 135 2e-31
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 135 2e-31
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 135 2e-31
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 135 2e-31
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 135 2e-31
gi|187608516 centaurin, beta 2 [Homo sapiens] 130 6e-30
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 129 1e-29
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 129 1e-29
gi|46094081 development and differentiation enhancing factor 1 [... 119 1e-26
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 118 3e-26
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 118 3e-26
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 111 3e-24
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 1825 bits (4728), Expect = 0.0
Identities = 911/911 (100%), Positives = 911/911 (100%)
Query: 1 MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQ 60
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQ
Sbjct: 1 MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQ 60
Query: 61 FALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWT 120
FALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWT
Sbjct: 61 FALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWT 120
Query: 121 LSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRD 180
LSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRD
Sbjct: 121 LSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRD 180
Query: 181 EGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISA 240
EGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISA
Sbjct: 181 EGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISA 240
Query: 241 ANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCK 300
ANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCK
Sbjct: 241 ANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCK 300
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST
Sbjct: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK
Sbjct: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP
Sbjct: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ
Sbjct: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT
Sbjct: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN
Sbjct: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD
Sbjct: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS
Sbjct: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL
Sbjct: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNP 900
LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNP
Sbjct: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNP 900
Query: 901 SAELHRSPSLL 911
SAELHRSPSLL
Sbjct: 901 SAELHRSPSLL 911
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 1225 bits (3169), Expect = 0.0
Identities = 612/859 (71%), Positives = 716/859 (83%), Gaps = 12/859 (1%)
Query: 60 QFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEW 119
Q L+NSAAIRAEIQRFESVHPNIY+IY+L+ER+E+ LQNQIREHVI+IED+FVNSQEW
Sbjct: 4 QQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEW 63
Query: 120 TLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 179
TLSRSVPELKVGIVGNL+SGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR
Sbjct: 64 TLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 123
Query: 180 DEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAIS 239
DEGGPPE QFA WVDAV+FVFSLEDEISFQTVY+Y+ R+ ++RN SE+P+VLVGTQDAIS
Sbjct: 124 DEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAIS 183
Query: 240 AANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPC 299
+ANPRVIDD+RARKLS DLKRCTYYETCATYGLNVERVFQDVAQK+VA RKKQQL+IGPC
Sbjct: 184 SANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPC 243
Query: 300 KSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASS 359
KSLPNSPSHS+V +A + AVHI+Q +NGGGS SDYSSSVPSTPS SQ+ELRI+ ++
Sbjct: 244 KSLPNSPSHSSVCSAQVSAVHISQTSNGGGS-LSDYSSSVPSTPSTSQKELRIDVPPTAN 302
Query: 360 TPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLN 419
TPTP+RKQSKRRSN+FTSRKG+D D+EKK E + DSIGSGRAIPIKQG+LLKRSGKSLN
Sbjct: 303 TPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLN 362
Query: 420 KEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTS 479
KEWKKKYVTLCDNG+LTYHPSLHDYMQN+HGKEIDLLRTTVKVPGKR PRAT A AP +S
Sbjct: 363 KEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISS 422
Query: 480 PRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSAD 539
P+ NGLS + S+ + +G SAS + + S L S RP+G+HQRS SVSSAD
Sbjct: 423 PKTNGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSF---NSRPDGMHQRSYSVSSAD 479
Query: 540 QWSEATT------SLPPGM-QHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPR 592
QWSEAT S G+ S P+ ++SPKLDPPPSPH+NRKKHRRKKST +
Sbjct: 480 QWSEATVIANSAISSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFK 539
Query: 593 PDGPSSATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKD 652
DG S EE EE+FEF++VSLTGQTWHFEA+T EER+ WVQ++++QILASLQ C S+K+
Sbjct: 540 ADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKN 599
Query: 653 KTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLS 712
K+RL +Q+ A+A+Q++R +RGNS C+DC+ NP+WASLNLGALMCIECSGIHR+LG HLS
Sbjct: 600 KSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLS 659
Query: 713 RVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQK 772
RVRSLDLDDWP EL+ VM+++GN LANSVWE + G +KP D+ REEKERWIRAKYEQK
Sbjct: 660 RVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQK 719
Query: 773 LFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAM 832
LFLAPLP +++ LGQ LLRA ++DLR ++LLAHGS++EVNET G+GDGRTALHL+
Sbjct: 720 LFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRK 779
Query: 833 ANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNR 892
NVV QLLIWYGVDV +RDA G T LAYAR+A SQEC D+L+Q+GCP E L TPN
Sbjct: 780 GNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNL 839
Query: 893 EPANGTNPSAELHRSPSLL 911
N N + R P+++
Sbjct: 840 SRRN-NNRNNSSGRVPTII 857
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 1175 bits (3039), Expect = 0.0
Identities = 590/852 (69%), Positives = 691/852 (81%), Gaps = 51/852 (5%)
Query: 60 QFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEW 119
Q L+NSAAIRAEIQRFESVHPNIY+IY+L+ER+E+ LQNQIREHVI+IED+FVNSQEW
Sbjct: 4 QQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDAFVNSQEW 63
Query: 120 TLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 179
TLSRSVPELKVGIVGNL+SGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR
Sbjct: 64 TLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIR 123
Query: 180 DEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAIS 239
DEGGPPE QFA WVDAV+FVFSLEDEISFQTVY+Y+ R+ ++RN SE+P+VLVGTQDAIS
Sbjct: 124 DEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRMANYRNTSEIPLVLVGTQDAIS 183
Query: 240 AANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPC 299
+ANPRVIDD+RARKLS DLKRCTYYETCATYGLNVERVFQDVAQK+VA RKKQQL+IGPC
Sbjct: 184 SANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVATRKKQQLSIGPC 243
Query: 300 KSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASS 359
KSLPNSPSHS+V +A + AVHI+Q +NGGGS SDYSSSVPSTPS SQ+ELRI+ ++
Sbjct: 244 KSLPNSPSHSSVCSAQVSAVHISQTSNGGGS-LSDYSSSVPSTPSTSQKELRIDVPPTAN 302
Query: 360 TPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLN 419
TPTP+RKQSKRRSN+FTSRKG+D D+EKK E + DSIGSGRAIPIKQG+LLKRSGKSLN
Sbjct: 303 TPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLN 362
Query: 420 KEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTS 479
KEWKKKYVTLCDNG+LTYHPSLHDYMQN+HGKEIDLLRTTVKVPGKR PRAT A AP +S
Sbjct: 363 KEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISS 422
Query: 480 PRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSAD 539
P+ NGLS + S+ + S +S+ L S + P S+SS
Sbjct: 423 PKTNGLSKDMSSLHI-------------SPNSDTGLGDSVCSSP----------SISS-- 457
Query: 540 QWSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSA 599
++SPKLDPPPSPH+NRKKHRRKKST + DG S
Sbjct: 458 ------------------------TTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGT 493
Query: 600 TEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQ 659
EE EE+FEF++VSLTGQTWHFEA+T EER+ WVQ++++QILASLQ C S+K+K+RL +Q
Sbjct: 494 AEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQ 553
Query: 660 NAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDL 719
+ A+A+Q++R +RGNS C+DC+ NP+WASLNLGALMCIECSGIHR+LG HLSRVRSLDL
Sbjct: 554 SEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDL 613
Query: 720 DDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLP 779
DDWP EL+ VM+++GN LANSVWE + G +KP D+ REEKERWIRAKYEQKLFLAPLP
Sbjct: 614 DDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLP 673
Query: 780 SSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQ 839
+++ LGQ LLRA ++DLR ++LLAHGS++EVNET G+GDGRTALHL+ NVV Q
Sbjct: 674 CTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQ 733
Query: 840 LLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTN 899
LLIWYGVDV +RDA G T LAYAR+A SQEC D+L+Q+GCP E L TPN N N
Sbjct: 734 LLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRRN-NN 792
Query: 900 PSAELHRSPSLL 911
+ R P+++
Sbjct: 793 RNNSSGRVPTII 804
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 833 bits (2153), Expect = 0.0
Identities = 452/846 (53%), Positives = 583/846 (68%), Gaps = 42/846 (4%)
Query: 67 AAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVP 126
AA+RAE++R E + + L ER++D LQ+ I+ + SI ++ +NSQEWTLSRS+P
Sbjct: 10 AAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQEWTLSRSIP 69
Query: 127 ELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPE 186
EL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ++L+LIR+E G P+
Sbjct: 70 ELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPD 129
Query: 187 LQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASE--VPMVLVGTQDAISAANPR 244
+F+ W DAV+FVFSLEDE SFQ V +L S R + + LVGTQD ISA++PR
Sbjct: 130 AKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPR 189
Query: 245 VIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPN 304
V+ D+RAR L D+KRC+YYETCATYGLNV+RVFQ+VAQKVV LRK+QQL + CKSLP+
Sbjct: 190 VVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQL-LAACKSLPS 248
Query: 305 SPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIET--IAASSTPT 362
SPSHSA AS P QA+NGG + SDYSSS+PS+P++ RELR E +A STP
Sbjct: 249 SPSHSA---ASTPVA--GQASNGGHT--SDYSSSLPSSPNVGHRELRAEAAAVAGLSTPG 301
Query: 363 PIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEW 422
+ + +KRR+++F +R+G+D EK++ + + ++ GSGRAIPIKQ LLKRSG SLNKEW
Sbjct: 302 SLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEW 359
Query: 423 KKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRA 482
KKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKR PRA A P S
Sbjct: 360 KKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSAS--I 417
Query: 483 NGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQWS 542
NGL + S Q+G G A + + S P SS P H + A S
Sbjct: 418 NGLVKDMSTVQMGEGLEA-----TTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALS 472
Query: 543 EATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEE 602
T P G P S +PPPSP KK RRKK T + +G SA +
Sbjct: 473 --TDCTPSGDLSPLSR-----------EPPPSPMV--KKQRRKKLTTPSKTEG--SAGQA 515
Query: 603 AEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAA 662
EE+FEF++VS TGQTWHFEA++ EER+ WVQ++++QILASLQ C S+K K R +Q+ A
Sbjct: 516 EEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEA 575
Query: 663 LAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDW 722
+A+QA+R +GNS C+DC APNP WASLNLGAL+CIECSGIHR+LG HLSRVRSLDLDDW
Sbjct: 576 VAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDW 635
Query: 723 PPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSD 782
P EL V+TA+GN AN VWE G +KP D+ REE+E WIRAKYEQ LFLAPL +S+
Sbjct: 636 PRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSE 695
Query: 783 VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLI 842
PLG+QL AV D+ +++LLAH ++ + D R+ LHL++ +A+VV TQLL+
Sbjct: 696 EPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLL 755
Query: 843 WYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSA 902
WYG DV +RDA+G T L YAR+AGSQ CADIL+QHGCPGEG A TP+ T PS
Sbjct: 756 WYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSA----ATTPSI 811
Query: 903 ELHRSP 908
SP
Sbjct: 812 TATPSP 817
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 801 bits (2069), Expect = 0.0
Identities = 436/817 (53%), Positives = 556/817 (68%), Gaps = 58/817 (7%)
Query: 114 VNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQS 173
+NSQEWTLSRS+PEL++G++G+ SGKS+L+HR+LTG+Y E E ++KKE++VDGQ+
Sbjct: 393 INSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQT 452
Query: 174 YLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASE--VPMVL 231
+L+LIR+E G P+ +F+ W DAV+FVFSLEDE SFQ V +L S R + + L
Sbjct: 453 HLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALAL 512
Query: 232 VGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKK 291
VGTQD ISA++PRV+ D+RAR L D+KRC+YYETCATYGLNV+RVFQ+VAQKVV LRK+
Sbjct: 513 VGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQ 572
Query: 292 QQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELR 351
QQL + CKSLP+SPSHSA AS P QA+NGG + SDYSSS+PS+P++ RELR
Sbjct: 573 QQL-LAACKSLPSSPSHSA---ASTPVA--GQASNGGHT--SDYSSSLPSSPNVGHRELR 624
Query: 352 IET--IAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGI 409
E +A STP + + +KRR+++F +R+G+D EK++ + + ++ GSGRAIPIKQ
Sbjct: 625 AEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSF 682
Query: 410 LLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPR 469
LLKRSG SLNKEWKKKYVTL NG L YHPS++DY+ + HGKE+DLLRTTVKVPGKR PR
Sbjct: 683 LLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPR 742
Query: 470 ATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLH 529
A A P S NGL + S Q+G G A + + S P SS P H
Sbjct: 743 AISAFGPSAS--INGLVKDMSTVQMGEGLEA-----TTPMPSPSPSPSSLQPPPDQTSKH 795
Query: 530 QRSCSVSSADQWSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTG 589
+ A S T P G P S +PPPSP KK RRKK T
Sbjct: 796 LLKPDRNLARALS--TDCTPSGDLSPLSR-----------EPPPSPMV--KKQRRKKLTT 840
Query: 590 TPRPDGPSSATE------------------EAEESFEFVVVSLTGQTWHFEASTAEEREL 631
+ +G + E +AEE+FEF++VS TGQTWHFEA++ EER+
Sbjct: 841 PSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDA 900
Query: 632 WVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLN 691
WVQ++++QILASLQ C S+K K R +Q+ A+A+QA+R +GNS C+DC APNP WASLN
Sbjct: 901 WVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLN 960
Query: 692 LGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSK 751
LGAL+CIECSGIHR+LG HLSRVRSLDLDDWP EL V+TA+GN AN VWE G +K
Sbjct: 961 LGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAK 1020
Query: 752 PGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKE 811
P D+ REE+E WIRAKYEQ LFLAPL +S+ PLG+QL AV D+ +++LLAH
Sbjct: 1021 PSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHG 1080
Query: 812 EVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECA 871
++ + D R+ LHL++ +A+VV TQLL+WYG DV +RDA+G T L YAR+AGSQ CA
Sbjct: 1081 PLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCA 1140
Query: 872 DILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSP 908
DIL+QHGCPGEG A TP+ T PS SP
Sbjct: 1141 DILLQHGCPGEGGSAATTPSA----ATTPSITATPSP 1173
Score = 35.4 bits (80), Expect = 0.24
Identities = 31/110 (28%), Positives = 39/110 (35%), Gaps = 7/110 (6%)
Query: 464 GKRLPRATPATAPGTSP------RANGLSVERSNTQLGGGTGAPHSASSASLHSERPL-S 516
G P +PA A P R L L GG A S RPL S
Sbjct: 87 GAEPPALSPAPASPARPVSPAPGRRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLS 146
Query: 517 SSAWAGPRPEGLHQRSCSVSSADQWSEATTSLPPGMQHPASGPAEVLSSS 566
S +W GP PEG SS+ + L PA P + +++S
Sbjct: 147 SPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTS 196
Score = 32.0 bits (71), Expect = 2.7
Identities = 42/154 (27%), Positives = 55/154 (35%), Gaps = 22/154 (14%)
Query: 457 RTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSAS-------L 509
RTT + L + P SP A + G G+P A
Sbjct: 11 RTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEEPGKKRHERLF 70
Query: 510 HSERPL----SSSAWAGPRPEGLHQRSCS----VSSADQWSEATTSLPPGMQHPASGPAE 561
H + L SS+ G P L S VS A + ++PPG P SG
Sbjct: 71 HRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPGP--PLSGG-- 126
Query: 562 VLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDG 595
LS PK P +P S+R+ S G P P+G
Sbjct: 127 -LSPDPK--PGGAPTSSRRPLLSSPSWGGPEPEG 157
>gi|110227617 centaurin, gamma 3 isoform b [Homo sapiens]
Length = 396
Score = 741 bits (1913), Expect = 0.0
Identities = 376/376 (100%), Positives = 376/376 (100%)
Query: 1 MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQ 60
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQ
Sbjct: 1 MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQ 60
Query: 61 FALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWT 120
FALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWT
Sbjct: 61 FALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWT 120
Query: 121 LSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRD 180
LSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRD
Sbjct: 121 LSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRD 180
Query: 181 EGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISA 240
EGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISA
Sbjct: 181 EGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISA 240
Query: 241 ANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCK 300
ANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCK
Sbjct: 241 ANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCK 300
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST
Sbjct: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
Query: 361 PTPIRKQSKRRSNIFT 376
PTPIRKQSKRRSNIFT
Sbjct: 361 PTPIRKQSKRRSNIFT 376
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 592 bits (1526), Expect = e-169
Identities = 313/564 (55%), Positives = 394/564 (69%), Gaps = 53/564 (9%)
Query: 319 VHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSR 378
VHI + NGGGS ++YSSS+P TPS SQ +L ++TPTPI KQS SN+FTS
Sbjct: 38 VHITKKRNGGGS-LNNYSSSIPLTPSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSE 96
Query: 379 KGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYH 438
KG+D D+ +KA E D+IGSGRAIPIKQG+LLKRSGK L K WKKKYVTLC NG+LTY+
Sbjct: 97 KGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCSNGVLTYY 155
Query: 439 PSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGT 498
SL DYM+NIH KEIDL +T+KVPGK AT A AP +S ++NGLS +
Sbjct: 156 SSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDME-------- 207
Query: 499 GAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQWSEATTSLPPGMQHPASG 558
A S +S+ L S P S+SS
Sbjct: 208 -----ALHMSANSDIGLGDSICFSP----------SISS--------------------- 231
Query: 559 PAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEEAEESFEFVVVSLTGQT 618
++SPKL+ PPSPH+N+KKH +KKST + DG SS EE EE +F++VS+TGQT
Sbjct: 232 -----TTSPKLNLPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEE--KFMIVSVTGQT 284
Query: 619 WHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCI 678
HF+A+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+ A+A+Q+++ +RGNS C+
Sbjct: 285 CHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCV 344
Query: 679 DCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALA 738
DC+ NP WASLNLG LMCIECSGIHR LG LSRVRSL+LDDWP EL VM+++GN LA
Sbjct: 345 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 404
Query: 739 NSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDL 798
NS+WEG+ G +KP ++ REEKERWIR+KYE KLFLAPLP +++ LGQ LLRA ++DL
Sbjct: 405 NSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDL 464
Query: 799 RLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTP 858
R ++LLAHGS+EEVNET G+GDG TALHL+ NVV QLLIWYGVDV +RDA G T
Sbjct: 465 RTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 524
Query: 859 LAYARRAGSQECADILIQHGCPGE 882
L YAR+A SQEC ++L+Q+GCP E
Sbjct: 525 LTYARQASSQECINVLLQYGCPDE 548
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 573 bits (1476), Expect = e-163
Identities = 305/580 (52%), Positives = 388/580 (66%), Gaps = 82/580 (14%)
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
S+P+ HS ++ VHI + NGGGS ++YSSS+PSTPS SQ + + ++T
Sbjct: 162 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 216
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTP+ K+S R SN+FTS KG+D D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 217 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 275
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL +T+KVPGK AT A P
Sbjct: 276 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTP---- 331
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
+S +SN S + L S P S+SS
Sbjct: 332 ----ISTSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 360
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
++SPKL+PPPSPH+N+KKH +KKST
Sbjct: 361 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 387
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 388 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 439
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
A+A+Q+++ +RGN+ C+DC+ NP WASLNLG LMCIECSGIHR LG LSRVRSL+LD
Sbjct: 440 KAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD 499
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWP EL VM+++GN LANS+WEG+ G +KP + REEKERWIR+KYE+KLFLAPLP
Sbjct: 500 DWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPC 559
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
+++ LGQQLLRA ++DL+ ++LLAHGS+EEVNET G+GDG TALHL+ NVV QL
Sbjct: 560 TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 619
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCP 880
LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP
Sbjct: 620 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCP 659
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 571 bits (1472), Expect = e-163
Identities = 306/582 (52%), Positives = 388/582 (66%), Gaps = 82/582 (14%)
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
S+P+ HS ++ VHI + NGGGS ++YSSS+PSTPS SQ + + ++T
Sbjct: 185 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 239
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTP+ K+S R SN+FTS KG+D D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 240 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL +T+KVPGK AT A P
Sbjct: 299 TWKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTP---- 354
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
+S +SN S + L S P S+SS
Sbjct: 355 ----ISSSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 383
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
++SPKL+PPPSPH+N+KKH +KKST
Sbjct: 384 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 410
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 411 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 462
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
A+A+Q+++ +RGN+ C+DC+ NP WASLNLG LMCIECSGIHR LG HLSRVRSL+LD
Sbjct: 463 EAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELD 522
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWP EL VM+++ N LANS+WEG+ G +KP + REEKERWIR+KYE+KLFLAPLP
Sbjct: 523 DWPVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPC 582
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
+++ LGQQLLRA ++DL+ ++LLAHGS EEVNET G+GDG TALHL+ NVV QL
Sbjct: 583 TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQL 642
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 643 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 568 bits (1465), Expect = e-162
Identities = 304/582 (52%), Positives = 387/582 (66%), Gaps = 82/582 (14%)
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
S+P+ HS ++ VHI + NGGGS ++YSSS+PSTPS SQ + + ++T
Sbjct: 162 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 216
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTP+ K+S R SN+FTS KG+D D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 217 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 275
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL +T+KVPGK AT A P
Sbjct: 276 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTP---- 331
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
+S +SN S + L S P S+SS
Sbjct: 332 ----ISSSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 360
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
++SPKL+PPPSPH+N+KKH +KKST
Sbjct: 361 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 387
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 388 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 439
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
A+A+Q+++ +RGN+ C+DC+ NP WASLNLG LMCIECSGIH LG LSRVRSL+LD
Sbjct: 440 EAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELD 499
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWP EL VM+++GN LANS+WEG+ G +KP + REEKERWIR+KYE+KLFLAPLP
Sbjct: 500 DWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPC 559
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
+++ LGQQLL A ++DL+ ++LLAHGS+EEVNET G+GDG TALHL+ NVV QL
Sbjct: 560 TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 619
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 620 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 566 bits (1459), Expect = e-161
Identities = 304/582 (52%), Positives = 387/582 (66%), Gaps = 82/582 (14%)
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
S+P+ HS ++ VHI + NGGGS ++YSSS+PSTPS SQ + + ++T
Sbjct: 185 SIPDEQLHSF----AVSTVHITKNRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 239
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTP+ K+S R SN+FTS KG+ D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 240 PTPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL +T+KVPGK AT A AP
Sbjct: 299 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAP---- 354
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
+S +SN S + L S P S+SS
Sbjct: 355 ----ISSSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 383
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
++SPKL+PPPSPH+N+KKH +KKST
Sbjct: 384 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 410
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 411 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 462
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
A+A+Q+++ +RGN+ C+D + NP WASLNLG LMCIECSGIHR LG LSRVRSL+LD
Sbjct: 463 EAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD 522
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWP EL VM+++GN LANS+WEG+ G +KP + REEKERWIR+KYE+KLFLAPLP
Sbjct: 523 DWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPC 582
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
+++ LGQ LLRA ++DL+ ++LLAHGS+EEVNET G+GDG TALHL+ NVV QL
Sbjct: 583 TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 642
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 643 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 684
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 564 bits (1454), Expect = e-160
Identities = 302/582 (51%), Positives = 388/582 (66%), Gaps = 82/582 (14%)
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
S+P+ HS ++ VHI + NGGGS ++YSSS+PSTPS SQ + + ++T
Sbjct: 162 SIPDEQLHSF----AVSTVHITKNRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 216
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTP+ K+S R SN+FTS KG+D D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 217 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 275
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
WKKKYVTLC NG+LTY+ SL DYM+ IH KEIDL +T+KVPGK AT A
Sbjct: 276 TWKKKYVTLCSNGVLTYYSSLGDYMKYIHKKEIDLQTSTIKVPGKWPSLATLACT----- 330
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
P+SSS + +GL +
Sbjct: 331 ---------------------------------PISSS-----KSDGLSK---------- 342
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
+ T L + P+ ++ PKL+PPPSPH+N+KKH +KKST
Sbjct: 343 --DMDTGLGDSI---CFSPSISSTTIPKLNPPPSPHANKKKHLKKKSTNN---------- 387
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 388 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 439
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
A+A+Q+++ +RGN+ C+DC+ NP WASLNLG LMCIECSGIHR LG LSRVRSL+LD
Sbjct: 440 EAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD 499
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWP EL VM+++GN LANS+WEG+ G +KP + REEKERWIR+KYE+KLFLAPLP
Sbjct: 500 DWPVELRKVMSSIGNDLANSIWEGSSQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLPC 559
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
+++ LGQQLLRA ++DL+ ++LLAHGS+EEVNET G+GDG TALHL+ NVV QL
Sbjct: 560 TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 619
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 620 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 552 bits (1422), Expect = e-157
Identities = 299/582 (51%), Positives = 384/582 (65%), Gaps = 84/582 (14%)
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
S+P+ HS ++ VHI + NGGGS ++YSSS+P TPS SQ + + ++T
Sbjct: 185 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPPTPSTSQEDPQFSVPPTANT 239
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTP+ K+S R SN+FTS KG+D D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 240 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL +T+KVPGK AT A A
Sbjct: 299 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACA----- 353
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
P+SSS + GL + D
Sbjct: 354 ---------------------------------PISSS-----KSNGLSK------DMDT 369
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
+ PG+ ++SPKL+PPPSPH+N+KKH +KKST
Sbjct: 370 GLGDSICFSPGISS---------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 410
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C+S+K K++L +Q+
Sbjct: 411 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQS 462
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
A+A+Q+++ +RGN+ C+DC+ NP WASLNLG LMCIECSGIHR G LSRVRSL+LD
Sbjct: 463 EAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELD 522
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWP EL VM+++GN LANS+WEG+ G +KP + REEKE WIR+KYE+KLFLAPLP
Sbjct: 523 DWPVELRKVMSSIGNELANSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPC 582
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
+++ LGQQLLRA ++DL+ ++LLAHGS+EEVNET G+GDG TALHL+ NVV QL
Sbjct: 583 TELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQL 642
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
L GVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 643 L--XGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 682
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 551 bits (1419), Expect = e-156
Identities = 299/582 (51%), Positives = 383/582 (65%), Gaps = 84/582 (14%)
Query: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
S+P+ HS ++ VHI + NGGGS ++YSSS+P TPS SQ + + ++T
Sbjct: 185 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPPTPSTSQEDPQFSVPPTANT 239
Query: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
PTP+ K S R SN+FTS KG+D D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 240 PTPVCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 298
Query: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL +T+KVPGK AT A A
Sbjct: 299 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACA----- 353
Query: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
P+SSS + GL + D
Sbjct: 354 ---------------------------------PISSS-----KSNGLSK------DMDT 369
Query: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
+ PG+ ++SPKL+PPPSPH+N+KKH +KKST
Sbjct: 370 GLGDSICFSPGISS---------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 410
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C+S+K K++L +Q+
Sbjct: 411 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQS 462
Query: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
A+A+Q+++ +RGN+ C+DC+ NP WASLNLG LMCIECSGIHR G LSRVRSL+LD
Sbjct: 463 EAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELD 522
Query: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
DWP EL VM+++GN LANS+WEG+ G +KP + REEKE WIR+KYE+KLFLAPLP
Sbjct: 523 DWPVELRKVMSSIGNELANSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPC 582
Query: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
+++ LGQQLLRA ++DL+ ++LLAHGS+EEVNET G+GDG TALHL+ NVV QL
Sbjct: 583 TELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQL 642
Query: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
L GVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 643 L--XGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 682
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 237 bits (604), Expect = 4e-62
Identities = 113/176 (64%), Positives = 140/176 (79%)
Query: 707 LGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIR 766
L + SRVRSL+LDDWP EL VM+++GN LANS+WEG+ G +KP + REEKERWIR
Sbjct: 107 LHSFASRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIR 166
Query: 767 AKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTAL 826
+KYE+KLFLAPLP +D+ LGQQLLRA ++DL+ ++LLAHGS+EEVNET G+GDG TAL
Sbjct: 167 SKYEEKLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTAL 226
Query: 827 HLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
HL+ NVV QLLIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 227 HLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 282
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 149 bits (376), Expect = 1e-35
Identities = 110/361 (30%), Positives = 161/361 (44%), Gaps = 74/361 (20%)
Query: 602 EAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNA 661
++E F F VVS T ++ +A + +LWV +VQ+ I ++ R G +
Sbjct: 322 DSERRFCFEVVS-TSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSG 380
Query: 662 ALAVQA------------------------VRTVRGNSFCIDCDAPNPDWASLNLGALMC 697
LA+ + V++V GN+ C DC P P+WAS+NLG +C
Sbjct: 381 HLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLC 440
Query: 698 IECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYS--KPGPD 755
I+CSGIHR LG H S+VRSL LD W PEL+ +M +GN + N ++E + + KPGP
Sbjct: 441 IQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPS 500
Query: 756 ACREEKERWIRAKYEQKLFLAPLP-------SSDVPLGQQ-------------LLRAVVE 795
R+EKE WI AKY +K FL LP P GQ LR+ E
Sbjct: 501 CSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPE 560
Query: 796 ----------------------DDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMA 833
L + LAHG+ +VN G D T L ++A
Sbjct: 561 PPSEDLGSLHPGALLFRASGHPPSLPTMADALAHGA--DVNWVNGGQDNATPLIQATAAN 618
Query: 834 NVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNRE 893
+++ + L+ G +V D+ G PL +A G A + ++ G G + R+
Sbjct: 619 SLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGA---DLGARDSEGRD 675
Query: 894 P 894
P
Sbjct: 676 P 676
Score = 34.7 bits (78), Expect = 0.42
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 4/86 (4%)
Query: 789 LLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDV 848
L++A + L LL +G+ N D GR LH ++ + + L + G D+
Sbjct: 611 LIQATAANSLLACEFLLQNGA----NVNQADSAGRGPLHHATILGHTGLACLFLKRGADL 666
Query: 849 RSRDARGLTPLAYARRAGSQECADIL 874
+RD+ G PL A + + +L
Sbjct: 667 GARDSEGRDPLTIAMETANADIVTLL 692
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 142 bits (357), Expect = 2e-33
Identities = 82/201 (40%), Positives = 112/201 (55%), Gaps = 24/201 (11%)
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILA------------------ 642
E+ E F F V+S T ++ +A + + R+ WVQ+VQA I +
Sbjct: 324 EDIERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTA 382
Query: 643 --SLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIEC 700
S SA D G + ++ +Q V++V GNS C DC P+P WAS+NLG L+CIEC
Sbjct: 383 SPSTSSIDSATDTRERGVKGESV-LQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIEC 441
Query: 701 SGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGAL--GGYSKPGPDACR 758
SGIHR LG H S+VRSL LD W PELL +M +GN+ N ++E G KP + R
Sbjct: 442 SGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSR 501
Query: 759 EEKERWIRAKYEQKLFLAPLP 779
++KE WI+ KY +K FL P
Sbjct: 502 QDKEAWIKDKYVEKKFLRKAP 522
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/88 (31%), Positives = 43/88 (48%), Gaps = 2/88 (2%)
Query: 791 RAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRS 850
RA DL L LAHG+ EVN + +G+T L + +++ + L+ G DV
Sbjct: 674 RAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQ 731
Query: 851 RDARGLTPLAYARRAGSQECADILIQHG 878
RD+RG PL +A G + ++ G
Sbjct: 732 RDSRGRAPLHHATLLGRTGQVCLFLKRG 759
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 135 bits (339), Expect = 2e-31
Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)
Query: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728
+ +R + C DC P+P WAS+N G +C EC +HR LG H+S+VR L WPP LL
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780
++ + N ANS+WE +L G K P D K +IRAKY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834
D L +QL +V +L + LL+ G++ + G T LH++S
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
Query: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ +LL YG D ++D+ G TP+ YAR+ G E A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 135 bits (339), Expect = 2e-31
Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)
Query: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728
+ +R + C DC P+P WAS+N G +C EC +HR LG H+S+VR L WPP LL
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780
++ + N ANS+WE +L G K P D K +IRAKY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834
D L +QL +V +L + LL+ G++ + G T LH++S
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
Query: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ +LL YG D ++D+ G TP+ YAR+ G E A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 135 bits (339), Expect = 2e-31
Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)
Query: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728
+ +R + C DC P+P WAS+N G +C EC +HR LG H+S+VR L WPP LL
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780
++ + N ANS+WE +L G K P D K +IRAKY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834
D L +QL +V +L + LL+ G++ + G T LH++S
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
Query: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ +LL YG D ++D+ G TP+ YAR+ G E A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 135 bits (339), Expect = 2e-31
Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)
Query: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728
+ +R + C DC P+P WAS+N G +C EC +HR LG H+S+VR L WPP LL
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780
++ + N ANS+WE +L G K P D K +IRAKY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834
D L +QL +V +L + LL+ G++ + G T LH++S
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
Query: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ +LL YG D ++D+ G TP+ YAR+ G E A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 135 bits (339), Expect = 2e-31
Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)
Query: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728
+ +R + C DC P+P WAS+N G +C EC +HR LG H+S+VR L WPP LL
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780
++ + N ANS+WE +L G K P D K +IRAKY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834
D L +QL +V +L + LL+ G++ + G T LH++S
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
Query: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ +LL YG D ++D+ G TP+ YAR+ G E A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 135 bits (339), Expect = 2e-31
Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)
Query: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728
+ +R + C DC P+P WAS+N G +C EC +HR LG H+S+VR L WPP LL
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780
++ + N ANS+WE +L G K P D K +IRAKY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834
D L +QL +V +L + LL+ G++ + G T LH++S
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
Query: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ +LL YG D ++D+ G TP+ YAR+ G E A+ L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 130 bits (327), Expect = 6e-30
Identities = 82/211 (38%), Positives = 112/211 (53%), Gaps = 29/211 (13%)
Query: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILA------------------ 642
E+ E F F VVS T ++ +A + + R+ W+++VQ I
Sbjct: 322 EDIERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSP 380
Query: 643 ---SLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIE 699
SL +K+K G A+Q V+ + GN+ C DC +P WAS+NLG +CIE
Sbjct: 381 STGSLDSGNESKEKLLKGES----ALQRVQCIPGNASCCDCGLADPRWASINLGITLCIE 436
Query: 700 CSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALG--GYSKPGPDAC 757
CSGIHR LG H S+VRSL LD W PELL +M +GN + N V+E + G KP P
Sbjct: 437 CSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQ- 495
Query: 758 REEKERWIRAKYEQKLFLAPLPSSDVPLGQQ 788
R+EKE +IRAKY ++ F+ S P QQ
Sbjct: 496 RQEKEAYIRAKYVERKFVDKYSISLSPPEQQ 526
Score = 37.7 bits (86), Expect = 0.049
Identities = 29/101 (28%), Positives = 47/101 (46%), Gaps = 2/101 (1%)
Query: 778 LPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVF 837
L S + G QL RA E +L + LAHG+ +VN + + T L + ++V
Sbjct: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
Query: 838 TQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHG 878
+ L+ G +V RD +G PL +A G + ++ G
Sbjct: 657 CEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRG 697
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 129 bits (324), Expect = 1e-29
Identities = 77/214 (35%), Positives = 112/214 (52%), Gaps = 17/214 (7%)
Query: 677 CIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNA 736
C DC AP+P WAS++ G L+C EC +HR LG H+S V+ L WPP LL ++ + +
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 737 LANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPSSD------ 782
ANS+WE +L G K P D K +IRAKY+ F+ LP D
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 783 VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLI 842
L +QL +V +L + LL+ G++ + G T LH+++ + +LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGTTPLHVAAKAGQTLQAELLV 187
Query: 843 WYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
YG D S D G TP+ YAR+AG E A+ L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 129 bits (324), Expect = 1e-29
Identities = 77/214 (35%), Positives = 112/214 (52%), Gaps = 17/214 (7%)
Query: 677 CIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNA 736
C DC AP+P WAS++ G L+C EC +HR LG H+S V+ L WPP LL ++ + +
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 737 LANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPSSD------ 782
ANS+WE +L G K P D K +IRAKY+ F+ LP D
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 783 VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLI 842
L +QL +V +L + LL+ G++ + G T LH+++ + +LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGTTPLHVAAKAGQTLQAELLV 187
Query: 843 WYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
YG D S D G TP+ YAR+AG E A+ L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 119 bits (298), Expect = 1e-26
Identities = 89/284 (31%), Positives = 140/284 (49%), Gaps = 14/284 (4%)
Query: 603 AEESFEFVVVSLTGQTWHFEASTAEERELWVQ----SVQAQILASLQGCRSAKDKTRLGN 658
AE+ F ++S +T+HF+A ++ W+ S + + + +G +SA + + L +
Sbjct: 379 AEDKKSFDLIS-HNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENS-LED 436
Query: 659 QNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLD 718
A+ ++ V+ + GN C DC + P W S NLG L CIECSGIHR +G H+SR++SL+
Sbjct: 437 LTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLE 495
Query: 719 LDDWPPELLAVMTAMGNALANSVWEGALGGYS-KPGPDACREEKERWIRAKYEQKLFLAP 777
LD L + +GN N + E L S KP P + ++ +I AKY F
Sbjct: 496 LDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 555
Query: 778 LPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSK--EEVNETYGDGDGRTALHLSSAMANV 835
S+ +LL A+ DL L+ + A G + E + E G G TALHL+ A+
Sbjct: 556 TCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETALHLAVRTADQ 614
Query: 836 VFTQL---LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
L L+ ++ + A G T L Y EC +L++
Sbjct: 615 TSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 118 bits (295), Expect = 3e-26
Identities = 82/270 (30%), Positives = 124/270 (45%), Gaps = 10/270 (3%)
Query: 617 QTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALA---VQAVRTVRG 673
+T+HF+A +E ++W+ +Q +L D T N L + V+ + G
Sbjct: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
Query: 674 NSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAM 733
N C DC AP+P W S NLG L CIECSGIHR LG H SR++SL LD L + +
Sbjct: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
Query: 734 GNALANSVWEGALGGYS--KPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLR 791
GNA N + E L KP P + ++ +I AKY ++ + + + L
Sbjct: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
Query: 792 AVVEDDLRLLVMLLAHG--SKEEVNETYGDGDGRTALHL---SSAMANVVFTQLLIWYGV 846
AV D+ L+ A G E++ G TALHL S ++ L+
Sbjct: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
Query: 847 DVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ + +G T L Y + EC +L++
Sbjct: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 118 bits (295), Expect = 3e-26
Identities = 82/270 (30%), Positives = 124/270 (45%), Gaps = 10/270 (3%)
Query: 617 QTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALA---VQAVRTVRG 673
+T+HF+A +E ++W+ +Q +L D T N L + V+ + G
Sbjct: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
Query: 674 NSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAM 733
N C DC AP+P W S NLG L CIECSGIHR LG H SR++SL LD L + +
Sbjct: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
Query: 734 GNALANSVWEGALGGYS--KPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLR 791
GNA N + E L KP P + ++ +I AKY ++ + + + L
Sbjct: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
Query: 792 AVVEDDLRLLVMLLAHG--SKEEVNETYGDGDGRTALHL---SSAMANVVFTQLLIWYGV 846
AV D+ L+ A G E++ G TALHL S ++ L+
Sbjct: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
Query: 847 DVRSRDARGLTPLAYARRAGSQECADILIQ 876
++ + +G T L Y + EC +L++
Sbjct: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 111 bits (278), Expect = 3e-24
Identities = 89/295 (30%), Positives = 133/295 (45%), Gaps = 29/295 (9%)
Query: 602 EAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNA 661
E ++ F+ V + +T+HF+A E E WV +Q +L + G+ +
Sbjct: 349 EEKKCFDLVTHN---RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 405
Query: 662 A-----------LAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAH 710
A L + V++ GNS C DC A +P W S NLG L CI+CSG+HR LG
Sbjct: 406 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 465
Query: 711 LSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKER--WIRAK 768
SR++SL LD P L + MGN N V E L + P P A + R +I AK
Sbjct: 466 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 525
Query: 769 YEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRT---- 824
Y + F P Q+L A+ D LL +L A + ++ + D +
Sbjct: 526 YVEHRFARRC----TPEPQRLWTAICNRD--LLSVLEAFANGQDFGQPLPGPDAQAPEEL 579
Query: 825 ALHLSSAMAN---VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
LHL+ +AN + +I G + ++ A G T L YA +C +L++
Sbjct: 580 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,508,671
Number of Sequences: 37866
Number of extensions: 2186253
Number of successful extensions: 15785
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 385
Number of HSP's successfully gapped in prelim test: 420
Number of HSP's that attempted gapping in prelim test: 11571
Number of HSP's gapped (non-prelim): 3559
length of query: 911
length of database: 18,247,518
effective HSP length: 111
effective length of query: 800
effective length of database: 14,044,392
effective search space: 11235513600
effective search space used: 11235513600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.