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Search of human proteins with 149363646
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo
sapiens]
(680 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 1356 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 1254 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 1203 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 922 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 920 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 900 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 856 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 856 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 854 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 853 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 850 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 735 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 688 0.0
gi|4505677 phosphodiesterase 1B [Homo sapiens] 238 1e-62
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 234 3e-61
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 234 3e-61
gi|4826894 phosphodiesterase 1C [Homo sapiens] 229 5e-60
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 224 3e-58
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 224 3e-58
gi|9506959 phosphodiesterase 7B [Homo sapiens] 213 5e-55
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 209 7e-54
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 209 7e-54
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 209 7e-54
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 209 7e-54
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 209 7e-54
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 208 2e-53
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 2e-49
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 171 3e-42
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 171 3e-42
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 171 3e-42
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 1356 bits (3509), Expect = 0.0
Identities = 680/680 (100%), Positives = 680/680 (100%)
Query: 1 MQGPPAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGLSCGR 60
MQGPPAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGLSCGR
Sbjct: 1 MQGPPAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGLSCGR 60
Query: 61 RALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIV 120
RALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIV
Sbjct: 61 RALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIV 120
Query: 121 TPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDE 180
TPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDE
Sbjct: 121 TPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDE 180
Query: 181 LDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTE 240
LDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTE
Sbjct: 181 LDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTE 240
Query: 241 VELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGL 300
VELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGL
Sbjct: 241 VELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGL 300
Query: 301 DVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLH 360
DVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLH
Sbjct: 301 DVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLH 360
Query: 361 AADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYN 420
AADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYN
Sbjct: 361 AADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYN 420
Query: 421 DASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLK 480
DASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLK
Sbjct: 421 DASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLK 480
Query: 481 TMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQG 540
TMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQG
Sbjct: 481 TMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQG 540
Query: 541 DRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNRE 600
DRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNRE
Sbjct: 541 DRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNRE 600
Query: 601 WYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 660
WYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE
Sbjct: 601 WYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 660
Query: 661 LLSPEAGPDPGDLPLDNQRT 680
LLSPEAGPDPGDLPLDNQRT
Sbjct: 661 LLSPEAGPDPGDLPLDNQRT 680
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 1254 bits (3244), Expect = 0.0
Identities = 631/631 (100%), Positives = 631/631 (100%)
Query: 50 FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV 109
FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV
Sbjct: 82 FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV 141
Query: 110 ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT 169
ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT
Sbjct: 142 ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT 201
Query: 170 GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY 229
GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY
Sbjct: 202 GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY 261
Query: 230 ISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLA 289
ISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLA
Sbjct: 262 ISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLA 321
Query: 290 KELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY 349
KELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY
Sbjct: 322 KELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY 381
Query: 350 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 409
HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI
Sbjct: 382 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 441
Query: 410 NTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDM 469
NTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDM
Sbjct: 442 NTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDM 501
Query: 470 SKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWT 529
SKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWT
Sbjct: 502 SKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWT 561
Query: 530 DRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQ 589
DRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQ
Sbjct: 562 DRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQ 621
Query: 590 DLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 649
DLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL
Sbjct: 622 DLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 681
Query: 650 AKEALELPDTELLSPEAGPDPGDLPLDNQRT 680
AKEALELPDTELLSPEAGPDPGDLPLDNQRT
Sbjct: 682 AKEALELPDTELLSPEAGPDPGDLPLDNQRT 712
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 1203 bits (3112), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 75 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 134
MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 135 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 194
SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 195 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 254
HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 180
Query: 255 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 314
MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL
Sbjct: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 240
Query: 315 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 374
TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT
Sbjct: 241 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 300
Query: 375 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 434
PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF
Sbjct: 301 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 360
Query: 435 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 494
KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL
Sbjct: 361 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 420
Query: 495 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 554
LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC
Sbjct: 421 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 480
Query: 555 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 614
DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT
Sbjct: 481 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 540
Query: 615 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 674
NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP
Sbjct: 541 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 600
Query: 675 LDNQRT 680
LDNQRT
Sbjct: 601 LDNQRT 606
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 922 bits (2383), Expect = 0.0
Identities = 466/638 (73%), Positives = 536/638 (84%), Gaps = 12/638 (1%)
Query: 48 LCFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNS 107
+CFD++NG S GR LDP +SPG G I+QA HSQRRESFLYRSDSDY+LSPK+MSRNS
Sbjct: 15 ICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNS 74
Query: 108 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 167
S+ASD+HG+D+IVTPFAQVLASLRTVR+N AAL Q +K+ P+ N S N+ E
Sbjct: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE 134
Query: 168 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 227
+ QKLA ETL+ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTHLSE SRSGNQVS
Sbjct: 135 EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 194
Query: 228 EYISRTFLDQQTEVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSSATVPRFGVQTDQ 284
E+IS TFLD+Q EVE+P T +E + PMS+ISG+ L HS+SL+++++PRFGV+T+Q
Sbjct: 195 EFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQ 254
Query: 285 EEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLM 344
E+ LAKELED NKWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+IP DTL TYL+
Sbjct: 255 EDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMT 314
Query: 345 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 404
LE HYHA+VAYHN++HAADV QSTHVLL+TPALEAVFTDLEILAA+FASAIHDVDHPGVS
Sbjct: 315 LEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVS 374
Query: 405 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 464
NQFLINTNSELALMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQR SLR+MVID+V
Sbjct: 375 NQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIV 434
Query: 465 LATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPL 524
LATDMSKHMNLLADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL L
Sbjct: 435 LATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL 494
Query: 525 YRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLV 584
YRQWTDRIM EFF+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI HPLWETWADLV
Sbjct: 495 YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLV 554
Query: 585 HPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG----PDRFQFELTLEEAEEEDEEE 640
HPDAQD+LDTLEDNREWYQS IP+SPS + +G ++FQFELTLEE E D E+
Sbjct: 555 HPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEK 614
Query: 641 EEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQ 678
+ + +E D++ L + + ++PLD Q
Sbjct: 615 DSGSQ----VEEDTSCSDSKTLCTQ-DSESTEIPLDEQ 647
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 920 bits (2377), Expect = 0.0
Identities = 479/710 (67%), Positives = 560/710 (78%), Gaps = 40/710 (5%)
Query: 4 PPAPAPVPGPGSPRG--SPRGSPG-------------LFRKLLVNQSIRLQ-------RR 41
PP P P P PG+ RG + G+ G L+ + + S ++ ++
Sbjct: 79 PPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKK 138
Query: 42 FTVAHPLCF------DLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSD 95
++ P F D++NG S GR LDP +SPG G I+QA HSQRRESFLYRSDSD
Sbjct: 139 SRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSD 198
Query: 96 YELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVG 155
Y+LSPK+MSRNSS+ASD+HG+D+IVTPFAQVLASLRTVR+N AAL Q +K+ P+
Sbjct: 199 YDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMC 258
Query: 156 NPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTH 215
N S N+ E+ QKLA ETL+ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTH
Sbjct: 259 NQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTH 318
Query: 216 LSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSS 272
LSE SRSGNQVSE+IS TFLD+Q EVE+P T +E + PMS+ISG+ L HS+SL++
Sbjct: 319 LSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTN 378
Query: 273 ATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQ 332
+++PRFGV+T+QE+ LAKELED NKWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+
Sbjct: 379 SSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFK 438
Query: 333 IPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFA 392
IP DTL TYL+ LE HYHA+VAYHN++HAADV QSTHVLL+TPALEAVFTDLEILAA+FA
Sbjct: 439 IPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFA 498
Query: 393 SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQ 452
SAIHDVDHPGVSNQFLINTNSELALMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQ
Sbjct: 499 SAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQ 558
Query: 453 RLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHC 512
R SLR+MVID+VLATDMSKHMNLLADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHC
Sbjct: 559 RQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHC 618
Query: 513 ADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 572
ADLSNPTKPL LYRQWTDRIM EFF+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI
Sbjct: 619 ADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI 678
Query: 573 AHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG----PDRFQFEL 628
HPLWETWADLVHPDAQD+LDTLEDNREWYQS IP+SPS + +G ++FQFEL
Sbjct: 679 VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFEL 738
Query: 629 TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQ 678
TLEE E D E++ + +E D++ L + + ++PLD Q
Sbjct: 739 TLEEDGESDTEKDSGSQ----VEEDTSCSDSKTLCTQ-DSESTEIPLDEQ 783
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 900 bits (2325), Expect = 0.0
Identities = 464/666 (69%), Positives = 541/666 (81%), Gaps = 12/666 (1%)
Query: 5 PAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGLSCGRRALD 64
P P SPR SPR SP FRKLLVN+SIR +RRFTVAH CFD+ENG S GR LD
Sbjct: 36 PGNRPTSPKISPRSSPRNSPCFFRKLLVNKSIRQRRRFTVAHT-CFDVENGPSPGRSPLD 94
Query: 65 PQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPF 123
PQ+S G ++ A P HSQRRESFLYRSDSDY+LSPKAMSRNSS+ S+ HG+D+IVTPF
Sbjct: 95 PQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPF 154
Query: 124 AQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDW 183
AQVLASLR+VR+N L + K+ P + +++ P E++ QKLA+ETL+ELDW
Sbjct: 155 AQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDW 213
Query: 184 CLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVEL 243
CLDQLET+QT SV EMASNKFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q +VE+
Sbjct: 214 CLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEI 273
Query: 244 PKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKW 298
P T ++ Q M++ISG+ L HS+SL++ ++ RFGV T+ E+ LAKELED NKW
Sbjct: 274 PSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKW 333
Query: 299 GLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNS 358
GL++F VA S NRPLT I+++IFQERDLLKTF+I +DT TY++ LE HYH++VAYHNS
Sbjct: 334 GLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNS 393
Query: 359 LHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALM 418
LHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALM
Sbjct: 394 LHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALM 453
Query: 419 YNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLAD 478
YND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVIDMVLATDMSKHM+LLAD
Sbjct: 454 YNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLAD 513
Query: 479 LKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQ 538
LKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L LYRQWTDRIM EFFQ
Sbjct: 514 LKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQ 573
Query: 539 QGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDN 598
QGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLV PDAQD+LDTLEDN
Sbjct: 574 QGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDN 633
Query: 599 REWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 654
R WYQS IP+SPS D N + G ++FQFELTL+E + E E+E EG + + L
Sbjct: 634 RNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTL 693
Query: 655 ELPDTE 660
+ D E
Sbjct: 694 CVIDPE 699
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 856 bits (2211), Expect = 0.0
Identities = 437/622 (70%), Positives = 512/622 (82%), Gaps = 11/622 (1%)
Query: 49 CFDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNS 107
CFD+ENG S GR LDPQ+S G ++ A P HSQRRESFLYRSDSDY+LSPKAMSRNS
Sbjct: 94 CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 153
Query: 108 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 167
S+ S+ HG+D+IVTPFAQVLASLR+VR+N L + K+ P + +++ P E
Sbjct: 154 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQE 212
Query: 168 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 227
++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNRELTHLSE SRSGNQVS
Sbjct: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
Query: 228 EYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQT 282
EYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+SL++ ++ RFGV T
Sbjct: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 332
Query: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLLKTF+I +DT TY+
Sbjct: 333 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
Query: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
+ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPG
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
Query: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 462
VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVID
Sbjct: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
Query: 463 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 522
MVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L
Sbjct: 513 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 572
Query: 523 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD 582
LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWAD
Sbjct: 573 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
Query: 583 LVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDE 638
LV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++FQFELTL+E + E
Sbjct: 633 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 692
Query: 639 EEEEEGEETALAKEALELPDTE 660
E+E EG + + L + D E
Sbjct: 693 EKEGEGHSYFSSTKTLCVIDPE 714
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 856 bits (2211), Expect = 0.0
Identities = 437/622 (70%), Positives = 512/622 (82%), Gaps = 11/622 (1%)
Query: 49 CFDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNS 107
CFD+ENG S GR LDPQ+S G ++ A P HSQRRESFLYRSDSDY+LSPKAMSRNS
Sbjct: 94 CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 153
Query: 108 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 167
S+ S+ HG+D+IVTPFAQVLASLR+VR+N L + K+ P + +++ P E
Sbjct: 154 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQE 212
Query: 168 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 227
++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNRELTHLSE SRSGNQVS
Sbjct: 213 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 272
Query: 228 EYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQT 282
EYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+SL++ ++ RFGV T
Sbjct: 273 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 332
Query: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLLKTF+I +DT TY+
Sbjct: 333 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 392
Query: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
+ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPG
Sbjct: 393 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 452
Query: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 462
VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVID
Sbjct: 453 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 512
Query: 463 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 522
MVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L
Sbjct: 513 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 572
Query: 523 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD 582
LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWAD
Sbjct: 573 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
Query: 583 LVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDE 638
LV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++FQFELTL+E + E
Sbjct: 633 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 692
Query: 639 EEEEEGEETALAKEALELPDTE 660
E+E EG + + L + D E
Sbjct: 693 EKEGEGHSYFSSTKTLCVIDPE 714
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 854 bits (2206), Expect = 0.0
Identities = 462/683 (67%), Positives = 530/683 (77%), Gaps = 39/683 (5%)
Query: 4 PPAPAPVPGPGSPRGSP----RGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGL--S 57
P AP P SP SP SP R+L + +S + R A F+ ENG S
Sbjct: 33 PLAPRAPRRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGA-GFEAENGPTPS 91
Query: 58 CGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGED 117
GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED
Sbjct: 92 PGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAED 149
Query: 118 MIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALET 177
+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E+T Q+LA ET
Sbjct: 150 LIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARET 208
Query: 178 LDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQ 237
L+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+
Sbjct: 209 LEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDK 268
Query: 238 QTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHSASLSSATVPR 277
Q EVE+P T +E AP QPMS+I+GL L HS SL+++ +PR
Sbjct: 269 QNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPR 328
Query: 278 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 337
FGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT
Sbjct: 329 FGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDT 388
Query: 338 LATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHD 397
+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHD
Sbjct: 389 MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD 448
Query: 398 VDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLR 457
VDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR
Sbjct: 449 VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR 508
Query: 458 RMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSN 517
+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSN
Sbjct: 509 KMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSN 568
Query: 518 PTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLW 577
PTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLW
Sbjct: 569 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLW 628
Query: 578 ETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLE 631
ETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G PD+FQFELTL
Sbjct: 629 ETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL- 687
Query: 632 EAEEEDEEEEEEGEETALAKEAL 654
EEE+EEE + A+EAL
Sbjct: 688 --EEEEEEEISMAQIPCTAQEAL 708
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 853 bits (2205), Expect = 0.0
Identities = 457/682 (67%), Positives = 526/682 (77%), Gaps = 37/682 (5%)
Query: 1 MQGPPAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGL--SC 58
M+ AP P P + P G L ++ R R + F+ ENG S
Sbjct: 1 MRSGAAPRARPRPPALALPPTGPESLTHFPFSDEDTR---RHPPGRSVSFEAENGPTPSP 57
Query: 59 GRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDM 118
GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+
Sbjct: 58 GRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDL 115
Query: 119 IVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETL 178
IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E+T Q+LA ETL
Sbjct: 116 IVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETL 174
Query: 179 DELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQ 238
+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q
Sbjct: 175 EELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQ 234
Query: 239 TEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHSASLSSATVPRF 278
EVE+P T +E AP QPMS+I+GL L HS SL+++ +PRF
Sbjct: 235 NEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRF 294
Query: 279 GVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTL 338
GV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+
Sbjct: 295 GVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTM 354
Query: 339 ATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDV 398
TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDV
Sbjct: 355 VTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDV 414
Query: 399 DHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRR 458
DHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+
Sbjct: 415 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRK 474
Query: 459 MVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNP 518
MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNP
Sbjct: 475 MVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNP 534
Query: 519 TKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
TKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWE
Sbjct: 535 TKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 594
Query: 579 TWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEE 632
TWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G PD+FQFELTL
Sbjct: 595 TWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL-- 652
Query: 633 AEEEDEEEEEEGEETALAKEAL 654
EEE+EEE + A+EAL
Sbjct: 653 -EEEEEEEISMAQIPCTAQEAL 673
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 850 bits (2197), Expect = 0.0
Identities = 447/633 (70%), Positives = 511/633 (80%), Gaps = 34/633 (5%)
Query: 50 FDLENGL--SCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNS 107
F+ ENG S GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNS
Sbjct: 108 FEAENGPTPSPGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 165
Query: 108 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 167
SV S+ H ED+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E
Sbjct: 166 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSE 224
Query: 168 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 227
+T Q+LA ETL+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVS
Sbjct: 225 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 284
Query: 228 EYISRTFLDQQTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHS 267
EYIS TFLD+Q EVE+P T +E AP QPMS+I+GL L HS
Sbjct: 285 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 344
Query: 268 ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDL 327
SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDL
Sbjct: 345 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 404
Query: 328 LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL 387
LK F+IP DT+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEIL
Sbjct: 405 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 464
Query: 388 AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN 447
AALFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQN
Sbjct: 465 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 524
Query: 448 LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ 507
LS +QR SLR+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+
Sbjct: 525 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 584
Query: 508 NLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVG 567
N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVG
Sbjct: 585 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 644
Query: 568 FIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------P 621
FIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G P
Sbjct: 645 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 704
Query: 622 DRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 654
D+FQFELTL EEE+EEE + A+EAL
Sbjct: 705 DKFQFELTL---EEEEEEEISMAQIPCTAQEAL 734
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 735 bits (1897), Expect = 0.0
Identities = 373/516 (72%), Positives = 432/516 (83%), Gaps = 12/516 (2%)
Query: 157 PSSSNQLPP---AEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNREL 213
P N +P AE++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNREL
Sbjct: 27 PLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNREL 86
Query: 214 THLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSA 268
THLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+
Sbjct: 87 THLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSS 146
Query: 269 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 328
SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLL
Sbjct: 147 SLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLL 206
Query: 329 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 388
KTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILA
Sbjct: 207 KTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILA 266
Query: 389 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 448
A+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL
Sbjct: 267 AIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNL 326
Query: 449 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 508
+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N
Sbjct: 327 TKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRN 386
Query: 509 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 568
+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGF
Sbjct: 387 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGF 446
Query: 569 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRF 624
IDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++F
Sbjct: 447 IDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKF 506
Query: 625 QFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 660
QFELTL+E + E E+E EG + + L + D E
Sbjct: 507 QFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 542
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 688 bits (1775), Expect = 0.0
Identities = 354/478 (74%), Positives = 397/478 (83%), Gaps = 29/478 (6%)
Query: 203 NKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP----- 252
++FKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
Query: 253 ----------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDV 302
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++
Sbjct: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Query: 303 FKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAA 362
F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLHAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
Query: 363 DVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDA 422
DV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
Query: 423 SVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTM 482
SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
Query: 483 VETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDR 542
VETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDR
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
Query: 543 ERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWY 602
ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
Query: 603 QSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 654
S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 495
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 238 bits (607), Expect = 1e-62
Identities = 134/383 (34%), Positives = 213/383 (55%), Gaps = 16/383 (4%)
Query: 292 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE-GHYH 350
L++ + W DVF + + + + L I+F + +L+ F+IP L ++L LE G+
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 351 ANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLIN 410
YHN +HAADV Q+ H L + +++E+LA +FA+AIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 411 TNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMS 470
T SE A++YND SVLENHH++ F+L+Q + +IF NL+ + + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 471 KHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTD 530
H + +KT ++ + D+ + L L+H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 531 RIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQD 590
+M EFF+QGD+E E GL SP+CD+ + V +SQ+GFID+I P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 591 LLDTLEDNREWYQSKIP-RSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 649
L D ED++ Q R PS PD F T + +E++++ +E + +
Sbjct: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGI 504
Query: 650 AKEALELPDTELLSPEAGPDPGD 672
+ + + + EA P P +
Sbjct: 505 TNQ-MSIDELSPCEEEAPPSPAE 526
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 234 bits (596), Expect = 3e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 218 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 277
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
Query: 278 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 337
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
Query: 338 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 396
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
Query: 397 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 456
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
Query: 457 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 516
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
Query: 517 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 576
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
Query: 577 WETWAD 582
+ D
Sbjct: 429 FSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 234 bits (596), Expect = 3e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 218 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 277
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
Query: 278 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 337
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
Query: 338 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 396
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
Query: 397 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 456
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
Query: 457 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 516
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
Query: 517 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 576
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
Query: 577 WETWAD 582
+ D
Sbjct: 429 FSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 229 bits (585), Expect = 5e-60
Identities = 123/305 (40%), Positives = 178/305 (58%), Gaps = 15/305 (4%)
Query: 292 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY-- 349
L+D +KW DVF + E SG+ L I + + DL+ F+IP L +++ LE Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 350 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 409
H N YHN +HAADV Q+ H LL + T+LEI A +F++AIHD +H G +N F I
Sbjct: 223 HKN-PYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHI 281
Query: 410 NTNSELALMYNDASVLENHHLAVGFKLLQ-AENCDIFQNLSAKQRLSLRRMVIDMVLATD 468
T S+ A++YND SVLENHHL+ ++LLQ E +I NLS R +VI+MV+ATD
Sbjct: 282 QTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATD 341
Query: 469 MSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQW 528
MS H + +KT ++ + ++ + L ++H AD+S+P K L+ +W
Sbjct: 342 MSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRW 390
Query: 529 TDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDA 588
T ++ EFF+QGDRE E GL SP+CD+ + V +SQVGFID+I P + D+
Sbjct: 391 TMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIV 450
Query: 589 QDLLD 593
L+D
Sbjct: 451 SPLID 455
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 224 bits (570), Expect = 3e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 437 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 496
Query: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 497 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 556
Query: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 461
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 557 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 616
Query: 462 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 510
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 617 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 676
Query: 511 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 569
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 677 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 736
Query: 570 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 603
DY +++ W V D DL+ L++N ++++
Sbjct: 737 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 768
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 224 bits (570), Expect = 3e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 483 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 542
Query: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 543 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 602
Query: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 461
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 603 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 662
Query: 462 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 510
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 663 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 722
Query: 511 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 569
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 723 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 782
Query: 570 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 603
DY +++ W V D DL+ L++N ++++
Sbjct: 783 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 213 bits (542), Expect = 5e-55
Identities = 122/396 (30%), Positives = 204/396 (51%), Gaps = 21/396 (5%)
Query: 255 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKE---LEDTNKWGLDVFKVAELSGN 311
+ R+ H++ L +P+ + E+ L + L W D+F L+
Sbjct: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
Query: 312 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 371
L ++ +F L+ F++ TL +L+M++ YH+ YHN++HAADV Q+ H
Sbjct: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
Query: 372 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 431
L P L + T L+I+ L A+A HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
Query: 432 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 491
+L+ + +L + + + + ++LATD+++ L LK + K
Sbjct: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
Query: 492 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 551
L L++ DR +LQ + CAD+ NP + + +QW++R+ EF++QG+ E++ L+IS
Sbjct: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 552 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPD--AQDLLDTLEDNREWYQSKIPRS 609
P+C++ S+ Q+GF+ YI PL+ WA ++++L L N+ ++S +PR
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
Query: 610 PSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGE 645
GPD + A + E EE+EG+
Sbjct: 421 HRS-RGSSGSGPDH-------DHAGQGTESEEQEGD 448
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 288 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 347
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 348 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 407
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
Query: 408 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 466
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
Query: 467 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 519
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 739
Query: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 740 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 799
Query: 579 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 612
W H A L+ L DN + W + K R PSD
Sbjct: 800 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 837
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 288 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 347
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 348 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 407
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646
Query: 408 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 466
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706
Query: 467 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 519
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 707 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 766
Query: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 767 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 826
Query: 579 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 612
W H A L+ L DN + W + K R PSD
Sbjct: 827 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 864
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 288 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 347
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 348 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 407
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611
Query: 408 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 466
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671
Query: 467 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 519
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 672 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 731
Query: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 732 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
Query: 579 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 612
W H A L+ L DN + W + K R PSD
Sbjct: 792 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 829
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 288 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 347
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 348 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 407
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569
Query: 408 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 466
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629
Query: 467 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 519
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 630 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 689
Query: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 690 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 749
Query: 579 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 612
W H A L+ L DN + W + K R PSD
Sbjct: 750 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 787
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 288 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 347
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 348 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 407
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666
Query: 408 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 466
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726
Query: 467 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 519
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 727 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 786
Query: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 578
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 787 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 846
Query: 579 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 612
W H A L+ L DN + W + K R PSD
Sbjct: 847 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 884
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 208 bits (529), Expect = 2e-53
Identities = 108/299 (36%), Positives = 166/299 (55%), Gaps = 8/299 (2%)
Query: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 113 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 172
Query: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 173 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 232
Query: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 462
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 233 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 290
Query: 463 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 522
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 291 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 344
Query: 523 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWA 581
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+GF+ Y+ PL+ WA
Sbjct: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (493), Expect = 2e-49
Identities = 103/290 (35%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 283 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 342
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 139 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 198
Query: 343 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 402
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 199 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 258
Query: 403 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 462
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 259 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 316
Query: 463 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 522
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 317 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 370
Query: 523 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 572
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+G Y+
Sbjct: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (432), Expect = 3e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 321 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 380
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 381 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 440
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 189
Query: 441 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 500
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 243
Query: 501 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 560
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 244 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 301
Query: 561 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 603
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 302 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 344
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (432), Expect = 3e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 321 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 380
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 381 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 440
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 189
Query: 441 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 500
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 243
Query: 501 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 560
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 244 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 301
Query: 561 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 603
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 302 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 344
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 171 bits (432), Expect = 3e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 321 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 380
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 310
Query: 381 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 440
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 311 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 370
Query: 441 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 500
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 371 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 424
Query: 501 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 560
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 425 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 482
Query: 561 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 603
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 483 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 525
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,176,648
Number of Sequences: 37866
Number of extensions: 1334419
Number of successful extensions: 19485
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 232
Number of HSP's successfully gapped in prelim test: 141
Number of HSP's that attempted gapping in prelim test: 15241
Number of HSP's gapped (non-prelim): 2392
length of query: 680
length of database: 18,247,518
effective HSP length: 109
effective length of query: 571
effective length of database: 14,120,124
effective search space: 8062590804
effective search space used: 8062590804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.