Guide to the Human Genome
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Search of human proteins with 149158709

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|149158709 histamine receptor H1 [Homo sapiens]
         (487 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|149158709 histamine receptor H1 [Homo sapiens]                     996   0.0  
gi|149158706 histamine receptor H1 [Homo sapiens]                     996   0.0  
gi|149158704 histamine receptor H1 [Homo sapiens]                     996   0.0  
gi|4504491 histamine receptor H1 [Homo sapiens]                       996   0.0  
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]          194   1e-49
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]          189   5e-48
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]         189   5e-48
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]         189   5e-48
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]         189   5e-48
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]         189   5e-48
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]         189   5e-48
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]         189   5e-48
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]         189   5e-48
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]         185   7e-47
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]         185   9e-47
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]          182   5e-46
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]               155   1e-37
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]           149   6e-36
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]              148   1e-35
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]               138   1e-32
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...   126   5e-29
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   122   7e-28
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]           121   1e-27
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]            121   1e-27
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      119   8e-27
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   118   1e-26
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...   118   1e-26
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   114   3e-25
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    113   4e-25
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    113   4e-25

>gi|149158709 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  996 bits (2574), Expect = 0.0
 Identities = 487/487 (100%), Positives = 487/487 (100%)

Query: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
           MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60

Query: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
           VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120

Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
           LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180

Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
           ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240

Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
           PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300

Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
           YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360

Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
           TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420

Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
           MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480

Query: 481 RILHIRS 487
           RILHIRS
Sbjct: 481 RILHIRS 487


>gi|149158706 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  996 bits (2574), Expect = 0.0
 Identities = 487/487 (100%), Positives = 487/487 (100%)

Query: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
           MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60

Query: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
           VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120

Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
           LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180

Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
           ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240

Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
           PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300

Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
           YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360

Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
           TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420

Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
           MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480

Query: 481 RILHIRS 487
           RILHIRS
Sbjct: 481 RILHIRS 487


>gi|149158704 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  996 bits (2574), Expect = 0.0
 Identities = 487/487 (100%), Positives = 487/487 (100%)

Query: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
           MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60

Query: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
           VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120

Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
           LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180

Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
           ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240

Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
           PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300

Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
           YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360

Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
           TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420

Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
           MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480

Query: 481 RILHIRS 487
           RILHIRS
Sbjct: 481 RILHIRS 487


>gi|4504491 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  996 bits (2574), Expect = 0.0
 Identities = 487/487 (100%), Positives = 487/487 (100%)

Query: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60
           MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
Sbjct: 1   MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60

Query: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120
           VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
Sbjct: 61  VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120

Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180
           LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180

Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240
           ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240

Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300
           PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300

Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360
           YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360

Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420
           TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420

Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480
           MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480

Query: 481 RILHIRS 487
           RILHIRS
Sbjct: 481 RILHIRS 487


>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
          Length = 532

 Score =  194 bits (494), Expect = 1e-49
 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%)

Query: 26  QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
           +++ +  V + + L+T+  N+LV+ + +   +L TV N Y++SL+ ADLI+G   M +  
Sbjct: 29  EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88

Query: 86  LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
            Y+LM +W+LG   C  WL++DYVAS AS+ ++ ++  DRY S+ +PL Y   RT  RA 
Sbjct: 89  TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148

Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
             I  AW +SF LW   IL W + + + +V   D+C+  F         TAI  FY+P  
Sbjct: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207

Query: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253
           +M   Y +IY+   +  +    +  S       K +P +          P+   A++   
Sbjct: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267

Query: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311
           ++ W   +R     G  S    PS    K  +     S     + DK    P L +V+  
Sbjct: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327

Query: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363
              E    ++ A       +K + +         L +  A+   + Q     +      +
Sbjct: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387

Query: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413
           D   ET  G  K+          +  S  GL+          SH       + + +ERKA
Sbjct: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440

Query: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473
           A+ L  I+ AFI+ W PY I  +V  FC  C    L     WL Y+NST+NP+ Y LCN 
Sbjct: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500

Query: 474 NFKKTFKRILHIR 486
            F+KTFK +L  R
Sbjct: 501 TFRKTFKMLLLCR 513


>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  189 bits (480), Expect = 5e-48
 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%)

Query: 18  NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73
           N   + SP    +++ +V+V  ++ LVT+  N+LV+ +++  R L TV N ++ SL+ AD
Sbjct: 10  NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69

Query: 74  LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133
           LI+G   M +  LY ++  W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL
Sbjct: 70  LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129

Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192
            Y   RT   A   I  AW LSF LW   IL W   +   +V  + +C   F+       
Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188

Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252
            TAI  FYLP ++M   Y  I +A +   +     ++  P  ++  + P   +G   KP 
Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244

Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312
             +        P    G  +  +  Q  K  + PV  +     E              ++
Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282

Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369
           + + +S   VA N    ++  DE  ++T   H   E S+   +       ++DS T T T
Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428
                 + S    G +      +++   ++Q        +RE+K  + +  I+ AFI+ W
Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400

Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            PY +  ++  FC  C    +     WL YINST+NP  Y LCN  FKKTFK +L
Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455


>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
          Length = 479

 Score =  185 bits (470), Expect = 7e-47
 Identities = 138/469 (29%), Positives = 211/469 (44%), Gaps = 42/469 (8%)

Query: 26  QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
           +++ +  V  ++ LVTV  N+LV+ +++  R+L TV N ++ SL+ ADLI+GA  M +  
Sbjct: 31  EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYT 90

Query: 86  LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
           +Y++   W LG  +C  WL++DYV S AS+ ++ I+  DRY  V +PL Y   RT   A 
Sbjct: 91  VYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAG 150

Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
             I  AW LSF LW   IL W   + + +V  +++C   F         TAI  FYLP +
Sbjct: 151 LMIAAAWVLSFVLWAPAILFWQFVVGKRTV-PDNQCFIQFLSNPAVTFGTAIAAFYLPVV 209

Query: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKP 264
           +M   Y  I  A R                   K RPE PK    K        ++K+  
Sbjct: 210 IMTVLYIHISLASRSRVH---------------KHRPEGPKEKKAKTLAFLKSPLMKQSV 254

Query: 265 KDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAV 324
           K    G   +   +  K  ++P        R V        D      ++ GS+      
Sbjct: 255 KKPPPGEAAREELRNGKLEEAPPPALPPPPRPV-------ADKDTSNESSSGSATQNTK- 306

Query: 325 NRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR---------TDSDTTTETAPG-KG 374
            R   +L T E       A  + + + L  +  +S+          +  T  E  P    
Sbjct: 307 ERPATELSTTEATTPAMPAPPL-QPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPA 365

Query: 375 KLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIF 434
            +R  +N    +      ++R   RQ  +     RERK  + +  I+ AFIL W PY + 
Sbjct: 366 GMRPAANVARKFASIARNQVRK-KRQMAA-----RERKVTRTIFAILLAFILTWTPYNVM 419

Query: 435 FMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
            +V  FC++C  + +     WL Y+NST+NP  Y LCN  FKKTF+ +L
Sbjct: 420 VLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 468


>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
          Length = 460

 Score =  185 bits (469), Expect = 9e-47
 Identities = 140/464 (30%), Positives = 212/464 (45%), Gaps = 66/464 (14%)

Query: 32  VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91
           +    + L TV  NLLVL + +   +L TV N +++SL+ ADLI+G   M +   YLLM 
Sbjct: 30  ITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMG 89

Query: 92  KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151
            W+LG   C  WL++DYVAS AS+ ++ ++  DRY SV +PL Y   RT  RA+  I  A
Sbjct: 90  HWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLA 149

Query: 152 WFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210
           W +SF LW   IL W + + + +V    +C   F         TA+  FYLP  +M   Y
Sbjct: 150 WLVSFVLWAPAILFWQYLVGERTV-LAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLY 208

Query: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270
            +IY+      +    +  S                  + PGK         + +    G
Sbjct: 209 WRIYRETENRARELAALQGS------------------ETPGKGGGSSSSSERSQPGAEG 250

Query: 271 SVLKSPSQTPKEMKSP---VVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRS 327
           S    P +  +  ++P     +S +++ E D                EGS     ++  S
Sbjct: 251 SPETPPGRCCRCCRAPRLLQAYSWKEEEEED----------------EGSME---SLTSS 291

Query: 328 HGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRT-----DSDTTTETAPGKGKLRSGSNT 382
            G    +E G      SE+     + D ++ + T      S  T +    KG+ R+G   
Sbjct: 292 EG----EEPG------SEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQ 341

Query: 383 GLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCK 442
                K   K   +  + +     + +E+KAA+ L  I+ AFIL W PY I  +V  FCK
Sbjct: 342 -----KPRGKEQLAKRKTF----SLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCK 392

Query: 443 NCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486
           +C  E L     WL Y+NST+NP+ Y LCN+ F+ TF+ +L  R
Sbjct: 393 DCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCR 436


>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
          Length = 590

 Score =  182 bits (463), Expect = 5e-46
 Identities = 137/500 (27%), Positives = 233/500 (46%), Gaps = 49/500 (9%)

Query: 26  QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
           Q++ +  +   + LVT+  N+LV+ + +  ++L TV N +++SL+ ADLI+G + M +  
Sbjct: 67  QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126

Query: 86  LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
            Y++M++W+LG   C  WL++DYVAS AS+ ++ ++  DRY S+ +PL Y   RT  RA 
Sbjct: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186

Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
             I  AW +SF LW   IL W +F+ + +V    +C   F         TAI  FY+P  
Sbjct: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTV-PPGECFIQFLSEPTITFGTAIAAFYMPVT 245

Query: 205 LMLWFYAKIYKAVRQHCQHRELINR---------------SLPSFSEIKLRPENPK-GDA 248
           +M   Y +IYK   +  +    +                 S  S S  +L+ ++ K  + 
Sbjct: 246 IMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNR 305

Query: 249 KKPGK------ESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQED-DREVDKLY 301
           +K G+         W+    +       S   + +     +++     +ED   E   +Y
Sbjct: 306 RKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIY 365

Query: 302 CFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGL--NTHGASEISEDQMLGDSQSF- 358
              L +         +       +  + Q+  +E G+      A ++   + + D  SF 
Sbjct: 366 SIVLKLPGHSTILNSTK----LPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFP 421

Query: 359 -----------SRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTW-KRLRSHSRQYVS--- 403
                      S  D+  T++     GK  S +   L + + T  KR    +R  ++   
Sbjct: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGK--STATLPLSFKEATLAKRFALKTRSQITKRK 479

Query: 404 GLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTL 463
            + + +E+KAA+ L  I+ AFI+ W PY I  +V  FC +C  +       WL YINST+
Sbjct: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539

Query: 464 NPLIYPLCNENFKKTFKRIL 483
           NP+ Y LCN+ F+ TFK +L
Sbjct: 540 NPVCYALCNKTFRTTFKMLL 559


>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
          Length = 462

 Score =  155 bits (391), Expect = 1e-37
 Identities = 128/460 (27%), Positives = 207/460 (45%), Gaps = 61/460 (13%)

Query: 30  LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
           L  V+  + + TV  N+LV+ AV + R L    NL++VSL+ AD++V  +VMP ++   L
Sbjct: 54  LAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANEL 113

Query: 90  MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
           M+ W  G+  C  +L++D +  T+SI  +  + +DRY SV Q + Y   RT  R  ATI+
Sbjct: 114 MAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIV 173

Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209
             W +S +   P L      +Q       +C  +  D TW+ + + I +F+ P L+M   
Sbjct: 174 AVWLISAVISFPPL--VSLYRQPDGAAYPQCGLN--DETWYILSSCIGSFFAPCLIMGLV 229

Query: 210 YAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGG 269
           YA+IY+  +       L  R+L      K  P  P  D   P  E+           A  
Sbjct: 230 YARIYRVAK-------LRTRTLSE----KRAPVGP--DGASPTTEN--------GLGAAA 268

Query: 270 GSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHG 329
           G+        P                       P D+   +++A    R      R  G
Sbjct: 269 GAGENGHCAPP-----------------------PADVEPDESSAAAERRRRRGALRRGG 305

Query: 330 QLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGK-GKLRSGSNTGLDYIK 388
           + +   +G    GA   ++ Q  G   + S      T   +PG  G+L   S+  +++  
Sbjct: 306 RRRAGAEG----GAGG-ADGQGAGPGAAES---GALTASRSPGPGGRLSRASSRSVEF-- 355

Query: 389 FTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCN-- 446
           F  +R R+ S      +   RE++    L  +M  F+LCW P+F  + +   C+  C   
Sbjct: 356 FLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVP 415

Query: 447 EHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486
             L  F  W+GY NS+LNP+IY + N++F+++FK IL  R
Sbjct: 416 GPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRR 455


>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
          Length = 443

 Score =  149 bits (376), Expect = 6e-36
 Identities = 126/457 (27%), Positives = 207/457 (45%), Gaps = 59/457 (12%)

Query: 33  VLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSK 92
           +L+ +  V V  N+LV  AV  E+ L T  N  IVSL+VADL+V  +VMP  +   ++ +
Sbjct: 40  LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99

Query: 93  WSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY-LKYRTKTRASATILGA 151
           W   R  C  ++++D +  TASI ++  + IDRY +V  P+ Y  +Y +K R +  I   
Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159

Query: 152 WFLSFLWVIPIL-GWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210
           W LSF    P+L G N+  Q   +               F V ++I++FY+P ++ L  Y
Sbjct: 160 WVLSFTISCPLLFGLNNADQNECIIANPA----------FVVYSSIVSFYVPFIVTLLVY 209

Query: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270
            KIY  +R+  + R    RS  +F      P   KG+   P       V           
Sbjct: 210 IKIYIVLRRR-RKRVNTKRSSRAFRAHLRAP--LKGNCTHPEDMKLCTV----------- 255

Query: 271 SVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQ 330
            ++KS    P   +      +  + E++ L           + +      Y  +  SH Q
Sbjct: 256 -IMKSNGSFPVNRRRVEAARRAQELEMEML----------SSTSPPERTRYSPIPPSHHQ 304

Query: 331 LKTDE---QGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYI 387
           L   +    GL++   S  ++ +  G ++   +       +T P  GK R+         
Sbjct: 305 LTLPDPSHHGLHSTPDSP-AKPEKNGHAKDHPKIAKIFEIQTMP-NGKTRTS-------- 354

Query: 388 KFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNE 447
                 L++ SR+ +S     +E+KA + L  ++  FI+CW+P+FI  ++   C      
Sbjct: 355 ------LKTMSRRKLS---QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPP 405

Query: 448 HLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILH 484
            L+    WLGY+NS +NP+IY   N  F+K F +ILH
Sbjct: 406 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILH 442


>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
          Length = 465

 Score =  148 bits (373), Expect = 1e-35
 Identities = 130/475 (27%), Positives = 206/475 (43%), Gaps = 63/475 (13%)

Query: 17  GNKTTMASPQL-MPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLI 75
           G + T  S Q+ + LV +   + L+TV  N+LV+ AV + R L    NL++VSL+ AD++
Sbjct: 37  GARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL 96

Query: 76  VGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY 135
           V  +V+P ++   +M  W  G+  C  +L++D +  T+SI  +  + +DRY S+ Q + Y
Sbjct: 97  VATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEY 156

Query: 136 LKYRTKTRASATILGAWFLSFLWVIPIL------GWNHFMQQTSVRREDKCETDFYDVTW 189
              RT  R  A I+  W +S +   P L      G     Q      E +CE +  D  W
Sbjct: 157 NLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA----EPRCEIN--DQKW 210

Query: 190 FKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAK 249
           + + + I +F+ P L+M+  Y +IY+  ++         R  PS          P G  +
Sbjct: 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRR-------TRVPPSRRGPDAVAAPPGGTER 263

Query: 250 KPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVH 309
           +P    P      +    GG      P+Q       P      D   +D           
Sbjct: 264 RPNGLGP-----ERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALD----------- 307

Query: 310 MQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTET 369
                E SS D+    R  G  +  E+G    G +  S+ +  GDS       +      
Sbjct: 308 ---LEESSSSDH--AERPPGP-RRPERGPRGKGKARASQVKP-GDSLPRRGPGATGIGTP 360

Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWI 429
           A G G+ R G+           K  R   RQ       NRE++    L  ++  F++CW 
Sbjct: 361 AAGPGEERVGAA----------KASRWRGRQ-------NREKRFTFVLAVVIGVFVVCWF 403

Query: 430 PYFIFFMVIAF-CKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
           P+F  + + A  C       L  F  W GY NS+LNP+IY + N +F++ FK+IL
Sbjct: 404 PFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456


>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
          Length = 450

 Score =  138 bits (348), Expect = 1e-32
 Identities = 115/478 (24%), Positives = 206/478 (43%), Gaps = 75/478 (15%)

Query: 30  LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
           +   ++ + L T+  N LV+ AV + R L    NL++VSL+ AD++V  +++P ++   L
Sbjct: 15  IAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL 74

Query: 90  MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
           +  W   R  C  +L++D +  T+SI  +  + +DRY +V + L Y   RT  R    IL
Sbjct: 75  LGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134

Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209
             W ++ +  +P L +    Q    R   +C+ +     W+ + ++I +F+ P L+M+  
Sbjct: 135 TVWLIAAVISLPPLIYKG-DQGPQPRGRPQCKLN--QEAWYILASSIGSFFAPCLIMILV 191

Query: 210 YAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGG 269
           Y +IY   ++                       N +G   K G   P +   ++P+   G
Sbjct: 192 YLRIYLIAKR----------------------SNRRGPRAKGG---PGQGESKQPRPDHG 226

Query: 270 GSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHG 329
           G++  +        K P + S    REV+       +    +   +  +R   A+  S  
Sbjct: 227 GALASA--------KLPALASVASAREVNGHSKSTGEKEEGETPEDTGTR---ALPPSWA 275

Query: 330 QLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPG----------------- 372
            L    QG    G    S +    + +     + +   +  P                  
Sbjct: 276 ALPNSGQG-QKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSR 334

Query: 373 -----KGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILC 427
                +G++  G   G   I   W R R+          + RE++    L  ++  F+LC
Sbjct: 335 VLATLRGQVLLGRGVGA--IGGQWWRRRA---------QLTREKRFTFVLAVVIGVFVLC 383

Query: 428 WIPYFIFFMVIAFC-KNCCNEH-LHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483
           W P+F  + + A C K+C   H L  F  W+GY NS+LNP+IY + N++F++ F+RIL
Sbjct: 384 WFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score =  126 bits (316), Expect = 5e-29
 Identities = 80/241 (33%), Positives = 123/241 (51%), Gaps = 13/241 (5%)

Query: 6   SSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLY 65
           ++C  E  M    KT      +   +VV++T+   T  LNL V+ A+ + +KLH   N  
Sbjct: 4   TNCTTEASMAIRPKTITEKMLICMTLVVITTL---TTLLNLAVIMAIGTTKKLHQPANYL 60

Query: 66  IVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDR 125
           I SL+V DL+V  +VMP++I+Y++M +W LG  LC  WLS+D    T SI  + ++ +DR
Sbjct: 61  ICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDR 120

Query: 126 YRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFY 185
           Y ++   + Y + RT  RA+  IL  W +S    +P L W    + +    +   + D  
Sbjct: 121 YWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHV 180

Query: 186 DVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQ----HRELINRSLP---SFSEIK 238
             T +  + A   FY+P  L+L  Y +IY A +   Q     R L NRS     SF+  K
Sbjct: 181 IYTIYSTLGA---FYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCK 237

Query: 239 L 239
           L
Sbjct: 238 L 238



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 38/88 (43%), Positives = 55/88 (62%), Gaps = 3/88 (3%)

Query: 399 RQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGY 458
           RQ +S     RERKAA+ LG I+ AFIL W+P+FI  +++       +  +  F  WLGY
Sbjct: 278 RQQISS---TRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGY 334

Query: 459 INSTLNPLIYPLCNENFKKTFKRILHIR 486
           +NS +NPL+Y   NE+FK  FK+++  R
Sbjct: 335 VNSLINPLLYTSFNEDFKLAFKKLIRCR 362


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  122 bits (306), Expect = 7e-28
 Identities = 75/243 (30%), Positives = 124/243 (51%), Gaps = 8/243 (3%)

Query: 2   SLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTV 61
           S P+ +C  +D + + +   ++ P  + LV++L+ I L T   N  V+  V   RKLHT 
Sbjct: 27  SAPSQNCSAKDYIYQDS---ISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTP 83

Query: 62  GNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFIL 121
            N  I SL+V DL+V  +VMP++ +Y +  +W+LG+ +C FWLS D    TASI  + ++
Sbjct: 84  ANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVI 143

Query: 122 CIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCE 181
            +DRY ++   + Y   RT  RA+  I   W  S    +P   W     +  V    +C 
Sbjct: 144 ALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEV---SECV 200

Query: 182 TDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRP 241
            +  D   + V + +  FY PTLL++  Y +IY   R     ++  NR+    +  +L  
Sbjct: 201 VN-TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL-KQTPNRTGKRLTRAQLIT 258

Query: 242 ENP 244
           ++P
Sbjct: 259 DSP 261



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 39/80 (48%), Positives = 57/80 (71%), Gaps = 2/80 (2%)

Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTI--WLGYINSTLNPL 466
           RERKA K LG I+ AFI+CW+P+FI  +V+  CK+ C  HL +F    WLGY+NS +NP+
Sbjct: 308 RERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPI 367

Query: 467 IYPLCNENFKKTFKRILHIR 486
           IY + NE+FK+ F +++  +
Sbjct: 368 IYTMSNEDFKQAFHKLIRFK 387


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score =  121 bits (304), Expect = 1e-27
 Identities = 70/199 (35%), Positives = 114/199 (57%), Gaps = 11/199 (5%)

Query: 30  LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
           + VVL+ + L+TV  N++V  AV   R+L  + N +IVSL++ DL++G +V+P + +Y L
Sbjct: 21  ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80

Query: 90  MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
             KWS G+  C  + S+D +  TASI ++F++ +DRY +V  PLRY    T  R + +++
Sbjct: 81  SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140

Query: 150 GAWF----LSFLWVIPILGWNHFMQQTSV--RREDKCETDFYDVTWFKVMTAIINFYLPT 203
             W     LSFL +   LGWN    +TS       KC+    +V  + ++  ++ FYLP 
Sbjct: 141 LIWVISITLSFLSI--HLGWNS-RNETSKGNHTTSKCKVQVNEV--YGLVDGLVTFYLPL 195

Query: 204 LLMLWFYAKIYKAVRQHCQ 222
           L+M   Y +I+K  R   +
Sbjct: 196 LIMCITYYRIFKVARDQAK 214



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 1/79 (1%)

Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFC-KNCCNEHLHMFTIWLGYINSTLNPLI 467
           RE KA   L  +M AFI+CW PYF  F+       +  NE L    +WLGY NS LNP++
Sbjct: 228 REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPIL 287

Query: 468 YPLCNENFKKTFKRILHIR 486
           Y   N +F+  ++++   R
Sbjct: 288 YAALNRDFRTGYQQLFCCR 306


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score =  121 bits (304), Expect = 1e-27
 Identities = 70/199 (35%), Positives = 114/199 (57%), Gaps = 11/199 (5%)

Query: 30  LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
           + VVL+ + L+TV  N++V  AV   R+L  + N +IVSL++ DL++G +V+P + +Y L
Sbjct: 21  ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80

Query: 90  MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
             KWS G+  C  + S+D +  TASI ++F++ +DRY +V  PLRY    T  R + +++
Sbjct: 81  SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140

Query: 150 GAWF----LSFLWVIPILGWNHFMQQTSV--RREDKCETDFYDVTWFKVMTAIINFYLPT 203
             W     LSFL +   LGWN    +TS       KC+    +V  + ++  ++ FYLP 
Sbjct: 141 LIWVISITLSFLSI--HLGWNS-RNETSKGNHTTSKCKVQVNEV--YGLVDGLVTFYLPL 195

Query: 204 LLMLWFYAKIYKAVRQHCQ 222
           L+M   Y +I+K  R   +
Sbjct: 196 LIMCITYYRIFKVARDQAK 214



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 1/79 (1%)

Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFC-KNCCNEHLHMFTIWLGYINSTLNPLI 467
           RE KA   L  +M AFI+CW PYF  F+       +  NE L    +WLGY NS LNP++
Sbjct: 228 REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPIL 287

Query: 468 YPLCNENFKKTFKRILHIR 486
           Y   N +F+  ++++   R
Sbjct: 288 YAALNRDFRTGYQQLFCCR 306


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  119 bits (297), Expect = 8e-27
 Identities = 62/195 (31%), Positives = 112/195 (57%), Gaps = 5/195 (2%)

Query: 32  VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91
           +V+S I L  V  N+LV+ A+    +L TV N +I SL+ ADL++G  V+P    ++LM 
Sbjct: 38  IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK 97

Query: 92  KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151
            W+ G   C FW S+D +  TASI ++ ++ +DRY ++  P +Y    TK +A   IL  
Sbjct: 98  MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMV 157

Query: 152 WFLSFLW-VIPI-LGWNHFMQQTSVR--REDKCETDFYDVTWFKVMTAIINFYLPTLLML 207
           W +S L   +PI + W     Q ++     + C  DF+    + + ++I++FY+P ++M+
Sbjct: 158 WIVSGLTSFLPIQMHWYRATHQEAINCYANETC-CDFFTNQAYAIASSIVSFYVPLVIMV 216

Query: 208 WFYAKIYKAVRQHCQ 222
           + Y+++++  ++  Q
Sbjct: 217 FVYSRVFQEAKRQLQ 231



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 31/78 (39%), Positives = 47/78 (60%), Gaps = 1/78 (1%)

Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIY 468
           +E KA K LG IM  F LCW+P+FI  +V     N   + +++   W+GY+NS  NPLIY
Sbjct: 267 KEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 326

Query: 469 PLCNENFKKTFKRILHIR 486
              + +F+  F+ +L +R
Sbjct: 327 -CRSPDFRIAFQELLCLR 343


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  118 bits (296), Expect = 1e-26
 Identities = 68/189 (35%), Positives = 99/189 (52%), Gaps = 4/189 (2%)

Query: 30  LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
           L VVLS I L TV  N  VL  +   RKLHT  N  I SL+  DL+V  +VMP++I Y +
Sbjct: 41  LAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTI 100

Query: 90  MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
              W+ G+ LC  WLS D    TASI  + ++ +DRY ++   L Y K RT   A+  I 
Sbjct: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160

Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209
             W +S    IP L W     Q  +     C  +   ++ + + +    FY+P++L++  
Sbjct: 161 IVWAISICISIPPLFWRQAKAQEEM---SDCLVNTSQIS-YTIYSTCGAFYIPSVLLIIL 216

Query: 210 YAKIYKAVR 218
           Y +IY+A R
Sbjct: 217 YGRIYRAAR 225



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 38/80 (47%), Positives = 56/80 (70%), Gaps = 2/80 (2%)

Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEH--LHMFTIWLGYINSTLNPL 466
           RERKA K LG I+ AFI+CW+P+F+  +V+  C++ C  H  L  F  WLGY+NS +NP+
Sbjct: 295 RERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPI 354

Query: 467 IYPLCNENFKKTFKRILHIR 486
           IY + NE F++ F++I+  R
Sbjct: 355 IYTVFNEEFRQAFQKIVPFR 374


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score =  118 bits (295), Expect = 1e-26
 Identities = 67/194 (34%), Positives = 104/194 (53%), Gaps = 5/194 (2%)

Query: 25  PQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMN 84
           P  + + + LS + L+T  +N LV+ A+   RKLH   N  I SL+V D +V  +VMP +
Sbjct: 21  PSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFS 80

Query: 85  ILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRA 144
           I+Y++   W +G+ +C  WLS+D    T SI  +  + +DRYR++   + Y + RT   A
Sbjct: 81  IVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHA 140

Query: 145 SATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
              I   W +S    +P L W H  Q TS  R+D+C    +D     + +    FY+P  
Sbjct: 141 GIMITIVWIISVFISMPPLFWRH--QGTS--RDDECIIK-HDHIVSTIYSTFGAFYIPLA 195

Query: 205 LMLWFYAKIYKAVR 218
           L+L  Y KIY+A +
Sbjct: 196 LILILYYKIYRAAK 209



 Score =  101 bits (252), Expect = 1e-21
 Identities = 58/152 (38%), Positives = 86/152 (56%), Gaps = 11/152 (7%)

Query: 343 ASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSH----- 397
           AS I+++++ G     S   S  +  T+    K  S  +T  D I  T + LRS      
Sbjct: 217 ASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEK 276

Query: 398 --SRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNC-CNEHLHMFTI 454
              RQ +SG    RERKAA  LG I+ AF++CW+P+F+  +V+  C  C  +E +  F  
Sbjct: 277 SWRRQKISG---TRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLA 333

Query: 455 WLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486
           WLGY+NS +NPLIY + NE+FKK F++++  R
Sbjct: 334 WLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  114 bits (284), Expect = 3e-25
 Identities = 65/191 (34%), Positives = 106/191 (55%), Gaps = 12/191 (6%)

Query: 32  VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91
           ++L T+    V  N  V+ A+  ER L  V N  I SL+V DL+V  +V+PM  LY +++
Sbjct: 41  LLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN 100

Query: 92  KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151
           KW+LG+  C  ++++D +  T+SI  +  + +DRY ++  P+ Y+  RT  RA+A I   
Sbjct: 101 KWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT 160

Query: 152 WFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVT---WFKVMTAIINFYLPTLLML 207
           W + FL  I P+LGW           ED+ + D   ++    + + +    FY+P LLML
Sbjct: 161 WLIGFLISIPPMLGWR--------TPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLML 212

Query: 208 WFYAKIYKAVR 218
             Y +I++A R
Sbjct: 213 VLYGRIFRAAR 223



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 41/100 (41%), Positives = 61/100 (61%), Gaps = 10/100 (10%)

Query: 390 TWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHL 449
           +++R    + +    + + RERK  K LG IM  FILCW+P+FI  +V+ FC++ C    
Sbjct: 320 SFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSC---- 375

Query: 450 HMFTI------WLGYINSTLNPLIYPLCNENFKKTFKRIL 483
           HM T+      WLGY NS LNP+IY   N++F+  FK+I+
Sbjct: 376 HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  113 bits (282), Expect = 4e-25
 Identities = 64/191 (33%), Positives = 108/191 (56%), Gaps = 7/191 (3%)

Query: 30  LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
           L V+L  + L  V  N+LV+ +V   R LH+V + YIV+L+VADL++ + V+P + ++ +
Sbjct: 29  LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88

Query: 90  MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
           +  W+ GR  C  W ++D +  TASI  + I+ IDRY  V  PLRY    T+ R    +L
Sbjct: 89  LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148

Query: 150 GAWFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLW 208
             W LS +  I P+ GW    +Q +   E  C+ +  +   + + +A+ +FYLP  ++L 
Sbjct: 149 CVWALSLVISIGPLFGW----RQPAPEDETICQIN--EEPGYVLFSALGSFYLPLAIILV 202

Query: 209 FYAKIYKAVRQ 219
            Y ++Y   ++
Sbjct: 203 MYCRVYVVAKR 213



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 34/83 (40%), Positives = 55/83 (66%), Gaps = 1/83 (1%)

Query: 405 LHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCC-NEHLHMFTIWLGYINSTL 463
           L  +RE+KAAK LG ++  F+LCW+P+F+   + +F  +   +E +     WLGY+NS +
Sbjct: 262 LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321

Query: 464 NPLIYPLCNENFKKTFKRILHIR 486
           NP+IYP  ++ FKK F+ +L I+
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  113 bits (282), Expect = 4e-25
 Identities = 64/191 (33%), Positives = 108/191 (56%), Gaps = 7/191 (3%)

Query: 30  LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89
           L V+L  + L  V  N+LV+ +V   R LH+V + YIV+L+VADL++ + V+P + ++ +
Sbjct: 29  LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88

Query: 90  MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149
           +  W+ GR  C  W ++D +  TASI  + I+ IDRY  V  PLRY    T+ R    +L
Sbjct: 89  LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148

Query: 150 GAWFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLW 208
             W LS +  I P+ GW    +Q +   E  C+ +  +   + + +A+ +FYLP  ++L 
Sbjct: 149 CVWALSLVISIGPLFGW----RQPAPEDETICQIN--EEPGYVLFSALGSFYLPLAIILV 202

Query: 209 FYAKIYKAVRQ 219
            Y ++Y   ++
Sbjct: 203 MYCRVYVVAKR 213



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 34/83 (40%), Positives = 55/83 (66%), Gaps = 1/83 (1%)

Query: 405 LHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCC-NEHLHMFTIWLGYINSTL 463
           L  +RE+KAAK LG ++  F+LCW+P+F+   + +F  +   +E +     WLGY+NS +
Sbjct: 262 LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321

Query: 464 NPLIYPLCNENFKKTFKRILHIR 486
           NP+IYP  ++ FKK F+ +L I+
Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,241,017
Number of Sequences: 37866
Number of extensions: 805950
Number of successful extensions: 4833
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 549
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 3151
Number of HSP's gapped (non-prelim): 1423
length of query: 487
length of database: 18,247,518
effective HSP length: 106
effective length of query: 381
effective length of database: 14,233,722
effective search space: 5423048082
effective search space used: 5423048082
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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