BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|149158706 histamine receptor H1 [Homo sapiens] (487 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|149158709 histamine receptor H1 [Homo sapiens] 996 0.0 gi|149158706 histamine receptor H1 [Homo sapiens] 996 0.0 gi|149158704 histamine receptor H1 [Homo sapiens] 996 0.0 gi|4504491 histamine receptor H1 [Homo sapiens] 996 0.0 gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 194 1e-49 gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 189 5e-48 gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 185 7e-47 gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 185 9e-47 gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 182 5e-46 gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 155 1e-37 gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] 149 6e-36 gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 148 1e-35 gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 138 1e-32 gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 126 5e-29 gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 122 7e-28 gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 121 1e-27 gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 121 1e-27 gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 119 8e-27 gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 118 1e-26 gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 118 1e-26 gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 114 3e-25 gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 113 4e-25 gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 113 4e-25 >gi|149158709 histamine receptor H1 [Homo sapiens] Length = 487 Score = 996 bits (2574), Expect = 0.0 Identities = 487/487 (100%), Positives = 487/487 (100%) Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 Query: 481 RILHIRS 487 RILHIRS Sbjct: 481 RILHIRS 487 >gi|149158706 histamine receptor H1 [Homo sapiens] Length = 487 Score = 996 bits (2574), Expect = 0.0 Identities = 487/487 (100%), Positives = 487/487 (100%) Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 Query: 481 RILHIRS 487 RILHIRS Sbjct: 481 RILHIRS 487 >gi|149158704 histamine receptor H1 [Homo sapiens] Length = 487 Score = 996 bits (2574), Expect = 0.0 Identities = 487/487 (100%), Positives = 487/487 (100%) Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 Query: 481 RILHIRS 487 RILHIRS Sbjct: 481 RILHIRS 487 >gi|4504491 histamine receptor H1 [Homo sapiens] Length = 487 Score = 996 bits (2574), Expect = 0.0 Identities = 487/487 (100%), Positives = 487/487 (100%) Query: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT Sbjct: 1 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT 60 Query: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI Sbjct: 61 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI 120 Query: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC Sbjct: 121 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC 180 Query: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR Sbjct: 181 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR 240 Query: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL Sbjct: 241 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL 300 Query: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR Sbjct: 301 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR 360 Query: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI Sbjct: 361 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI 420 Query: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK Sbjct: 421 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK 480 Query: 481 RILHIRS 487 RILHIRS Sbjct: 481 RILHIRS 487 >gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] Length = 532 Score = 194 bits (494), Expect = 1e-49 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%) Query: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85 +++ + V + + L+T+ N+LV+ + + +L TV N Y++SL+ ADLI+G M + Sbjct: 29 EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88 Query: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145 Y+LM +W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA Sbjct: 89 TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148 Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 I AW +SF LW IL W + + + +V D+C+ F TAI FY+P Sbjct: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207 Query: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253 +M Y +IY+ + + + S K +P + P+ A++ Sbjct: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267 Query: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311 ++ W +R G S PS K + S + DK P L +V+ Sbjct: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327 Query: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363 E ++ A +K + + L + A+ + Q + + Sbjct: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387 Query: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413 D ET G K+ + S GL+ SH + + +ERKA Sbjct: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440 Query: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473 A+ L I+ AFI+ W PY I +V FC C L WL Y+NST+NP+ Y LCN Sbjct: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500 Query: 474 NFKKTFKRILHIR 486 F+KTFK +L R Sbjct: 501 TFRKTFKMLLLCR 513 >gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 189 bits (480), Expect = 5e-48 Identities = 137/475 (28%), Positives = 219/475 (46%), Gaps = 38/475 (8%) Query: 18 NKTTMASP----QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVAD 73 N + SP +++ +V+V ++ LVT+ N+LV+ +++ R L TV N ++ SL+ AD Sbjct: 10 NSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD 69 Query: 74 LIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPL 133 LI+G M + LY ++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Sbjct: 70 LIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPL 129 Query: 134 RYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKV 192 Y RT A I AW LSF LW IL W + +V + +C F+ Sbjct: 130 TYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTV-EDGECYIQFFSNAAVTF 188 Query: 193 MTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPG 252 TAI FYLP ++M Y I +A + + ++ P ++ + P +G KP Sbjct: 189 GTAIAAFYLPVIIMTVLYWHISRASKSRIKK----DKKEPVANQDPVSPSLVQGRIVKPN 244 Query: 253 KESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQA 312 + P G + + Q K + PV + E ++ Sbjct: 245 NNN-------MPSSDDG--LEHNKIQNGKAPRDPVTENCVQGEE-------------KES 282 Query: 313 AAEGSSRDYVAVNRSHGQLKTDEQGLNT---HGASEISEDQMLGDSQSFSRTDSDTTTET 369 + + +S VA N ++ DE ++T H E S+ + ++DS T T T Sbjct: 283 SNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNT 342 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGL-HMNRERKAAKQLGFIMAAFILCW 428 + S G + +++ ++Q +RE+K + + I+ AFI+ W Sbjct: 343 T--VEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITW 400 Query: 429 IPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 PY + ++ FC C + WL YINST+NP Y LCN FKKTFK +L Sbjct: 401 APYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL 455 >gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] Length = 479 Score = 185 bits (470), Expect = 7e-47 Identities = 138/469 (29%), Positives = 211/469 (44%), Gaps = 42/469 (8%) Query: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85 +++ + V ++ LVTV N+LV+ +++ R+L TV N ++ SL+ ADLI+GA M + Sbjct: 31 EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYT 90 Query: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145 +Y++ W LG +C WL++DYV S AS+ ++ I+ DRY V +PL Y RT A Sbjct: 91 VYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAG 150 Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 I AW LSF LW IL W + + +V +++C F TAI FYLP + Sbjct: 151 LMIAAAWVLSFVLWAPAILFWQFVVGKRTV-PDNQCFIQFLSNPAVTFGTAIAAFYLPVV 209 Query: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKP 264 +M Y I A R K RPE PK K ++K+ Sbjct: 210 IMTVLYIHISLASRSRVH---------------KHRPEGPKEKKAKTLAFLKSPLMKQSV 254 Query: 265 KDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAV 324 K G + + K ++P R V D ++ GS+ Sbjct: 255 KKPPPGEAAREELRNGKLEEAPPPALPPPPRPV-------ADKDTSNESSSGSATQNTK- 306 Query: 325 NRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR---------TDSDTTTETAPG-KG 374 R +L T E A + + + L + +S+ + T E P Sbjct: 307 ERPATELSTTEATTPAMPAPPL-QPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPA 365 Query: 375 KLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIF 434 +R +N + ++R RQ + RERK + + I+ AFIL W PY + Sbjct: 366 GMRPAANVARKFASIARNQVRK-KRQMAA-----RERKVTRTIFAILLAFILTWTPYNVM 419 Query: 435 FMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 +V FC++C + + WL Y+NST+NP Y LCN FKKTF+ +L Sbjct: 420 VLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 468 >gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] Length = 460 Score = 185 bits (469), Expect = 9e-47 Identities = 140/464 (30%), Positives = 212/464 (45%), Gaps = 66/464 (14%) Query: 32 VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91 + + L TV NLLVL + + +L TV N +++SL+ ADLI+G M + YLLM Sbjct: 30 ITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMG 89 Query: 92 KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151 W+LG C WL++DYVAS AS+ ++ ++ DRY SV +PL Y RT RA+ I A Sbjct: 90 HWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLA 149 Query: 152 WFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210 W +SF LW IL W + + + +V +C F TA+ FYLP +M Y Sbjct: 150 WLVSFVLWAPAILFWQYLVGERTV-LAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLY 208 Query: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270 +IY+ + + S + PGK + + G Sbjct: 209 WRIYRETENRARELAALQGS------------------ETPGKGGGSSSSSERSQPGAEG 250 Query: 271 SVLKSPSQTPKEMKSP---VVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRS 327 S P + + ++P +S +++ E D EGS ++ S Sbjct: 251 SPETPPGRCCRCCRAPRLLQAYSWKEEEEED----------------EGSME---SLTSS 291 Query: 328 HGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRT-----DSDTTTETAPGKGKLRSGSNT 382 G +E G SE+ + D ++ + T S T + KG+ R+G Sbjct: 292 EG----EEPG------SEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQ 341 Query: 383 GLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCK 442 K K + + + + +E+KAA+ L I+ AFIL W PY I +V FCK Sbjct: 342 -----KPRGKEQLAKRKTF----SLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCK 392 Query: 443 NCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486 +C E L WL Y+NST+NP+ Y LCN+ F+ TF+ +L R Sbjct: 393 DCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCR 436 >gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] Length = 590 Score = 182 bits (463), Expect = 5e-46 Identities = 137/500 (27%), Positives = 233/500 (46%), Gaps = 49/500 (9%) Query: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85 Q++ + + + LVT+ N+LV+ + + ++L TV N +++SL+ ADLI+G + M + Sbjct: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126 Query: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145 Y++M++W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA Sbjct: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186 Query: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 I AW +SF LW IL W +F+ + +V +C F TAI FY+P Sbjct: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTV-PPGECFIQFLSEPTITFGTAIAAFYMPVT 245 Query: 205 LMLWFYAKIYKAVRQHCQHRELINR---------------SLPSFSEIKLRPENPK-GDA 248 +M Y +IYK + + + S S S +L+ ++ K + Sbjct: 246 IMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNR 305 Query: 249 KKPGK------ESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQED-DREVDKLY 301 +K G+ W+ + S + + +++ +ED E +Y Sbjct: 306 RKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIY 365 Query: 302 CFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGL--NTHGASEISEDQMLGDSQSF- 358 L + + + + Q+ +E G+ A ++ + + D SF Sbjct: 366 SIVLKLPGHSTILNSTK----LPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFP 421 Query: 359 -----------SRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTW-KRLRSHSRQYVS--- 403 S D+ T++ GK S + L + + T KR +R ++ Sbjct: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGK--STATLPLSFKEATLAKRFALKTRSQITKRK 479 Query: 404 GLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTL 463 + + +E+KAA+ L I+ AFI+ W PY I +V FC +C + WL YINST+ Sbjct: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539 Query: 464 NPLIYPLCNENFKKTFKRIL 483 NP+ Y LCN+ F+ TFK +L Sbjct: 540 NPVCYALCNKTFRTTFKMLL 559 >gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] Length = 462 Score = 155 bits (391), Expect = 1e-37 Identities = 128/460 (27%), Positives = 207/460 (45%), Gaps = 61/460 (13%) Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89 L V+ + + TV N+LV+ AV + R L NL++VSL+ AD++V +VMP ++ L Sbjct: 54 LAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANEL 113 Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149 M+ W G+ C +L++D + T+SI + + +DRY SV Q + Y RT R ATI+ Sbjct: 114 MAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIV 173 Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209 W +S + P L +Q +C + D TW+ + + I +F+ P L+M Sbjct: 174 AVWLISAVISFPPL--VSLYRQPDGAAYPQCGLN--DETWYILSSCIGSFFAPCLIMGLV 229 Query: 210 YAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGG 269 YA+IY+ + L R+L K P P D P E+ A Sbjct: 230 YARIYRVAK-------LRTRTLSE----KRAPVGP--DGASPTTEN--------GLGAAA 268 Query: 270 GSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHG 329 G+ P P D+ +++A R R G Sbjct: 269 GAGENGHCAPP-----------------------PADVEPDESSAAAERRRRRGALRRGG 305 Query: 330 QLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGK-GKLRSGSNTGLDYIK 388 + + +G GA ++ Q G + S T +PG G+L S+ +++ Sbjct: 306 RRRAGAEG----GAGG-ADGQGAGPGAAES---GALTASRSPGPGGRLSRASSRSVEF-- 355 Query: 389 FTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCN-- 446 F +R R+ S + RE++ L +M F+LCW P+F + + C+ C Sbjct: 356 FLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVP 415 Query: 447 EHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486 L F W+GY NS+LNP+IY + N++F+++FK IL R Sbjct: 416 GPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRR 455 >gi|4503385 dopamine receptor D2 isoform long [Homo sapiens] Length = 443 Score = 149 bits (376), Expect = 6e-36 Identities = 126/457 (27%), Positives = 207/457 (45%), Gaps = 59/457 (12%) Query: 33 VLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSK 92 +L+ + V V N+LV AV E+ L T N IVSL+VADL+V +VMP + ++ + Sbjct: 40 LLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE 99 Query: 93 WSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY-LKYRTKTRASATILGA 151 W R C ++++D + TASI ++ + IDRY +V P+ Y +Y +K R + I Sbjct: 100 WKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIV 159 Query: 152 WFLSFLWVIPIL-GWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFY 210 W LSF P+L G N+ Q + F V ++I++FY+P ++ L Y Sbjct: 160 WVLSFTISCPLLFGLNNADQNECIIANPA----------FVVYSSIVSFYVPFIVTLLVY 209 Query: 211 AKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGG 270 KIY +R+ + R RS +F P KG+ P V Sbjct: 210 IKIYIVLRRR-RKRVNTKRSSRAFRAHLRAP--LKGNCTHPEDMKLCTV----------- 255 Query: 271 SVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQ 330 ++KS P + + + E++ L + + Y + SH Q Sbjct: 256 -IMKSNGSFPVNRRRVEAARRAQELEMEML----------SSTSPPERTRYSPIPPSHHQ 304 Query: 331 LKTDE---QGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYI 387 L + GL++ S ++ + G ++ + +T P GK R+ Sbjct: 305 LTLPDPSHHGLHSTPDSP-AKPEKNGHAKDHPKIAKIFEIQTMP-NGKTRTS-------- 354 Query: 388 KFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNE 447 L++ SR+ +S +E+KA + L ++ FI+CW+P+FI ++ C Sbjct: 355 ------LKTMSRRKLS---QQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPP 405 Query: 448 HLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILH 484 L+ WLGY+NS +NP+IY N F+K F +ILH Sbjct: 406 VLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILH 442 >gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] Length = 465 Score = 148 bits (373), Expect = 1e-35 Identities = 130/475 (27%), Positives = 206/475 (43%), Gaps = 63/475 (13%) Query: 17 GNKTTMASPQL-MPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLI 75 G + T S Q+ + LV + + L+TV N+LV+ AV + R L NL++VSL+ AD++ Sbjct: 37 GARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADIL 96 Query: 76 VGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRY 135 V +V+P ++ +M W G+ C +L++D + T+SI + + +DRY S+ Q + Y Sbjct: 97 VATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEY 156 Query: 136 LKYRTKTRASATILGAWFLSFLWVIPIL------GWNHFMQQTSVRREDKCETDFYDVTW 189 RT R A I+ W +S + P L G Q E +CE + D W Sbjct: 157 NLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPA----EPRCEIN--DQKW 210 Query: 190 FKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAK 249 + + + I +F+ P L+M+ Y +IY+ ++ R PS P G + Sbjct: 211 YVISSCIGSFFAPCLIMILVYVRIYQIAKRR-------TRVPPSRRGPDAVAAPPGGTER 263 Query: 250 KPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVH 309 +P P + GG P+Q P D +D Sbjct: 264 RPNGLGP-----ERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALD----------- 307 Query: 310 MQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTET 369 E SS D+ R G + E+G G + S+ + GDS + Sbjct: 308 ---LEESSSSDH--AERPPGP-RRPERGPRGKGKARASQVKP-GDSLPRRGPGATGIGTP 360 Query: 370 APGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWI 429 A G G+ R G+ K R RQ NRE++ L ++ F++CW Sbjct: 361 AAGPGEERVGAA----------KASRWRGRQ-------NREKRFTFVLAVVIGVFVVCWF 403 Query: 430 PYFIFFMVIAF-CKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 P+F + + A C L F W GY NS+LNP+IY + N +F++ FK+IL Sbjct: 404 PFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456 >gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] Length = 450 Score = 138 bits (348), Expect = 1e-32 Identities = 115/478 (24%), Positives = 206/478 (43%), Gaps = 75/478 (15%) Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89 + ++ + L T+ N LV+ AV + R L NL++VSL+ AD++V +++P ++ L Sbjct: 15 IAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL 74 Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149 + W R C +L++D + T+SI + + +DRY +V + L Y RT R IL Sbjct: 75 LGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134 Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209 W ++ + +P L + Q R +C+ + W+ + ++I +F+ P L+M+ Sbjct: 135 TVWLIAAVISLPPLIYKG-DQGPQPRGRPQCKLN--QEAWYILASSIGSFFAPCLIMILV 191 Query: 210 YAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGG 269 Y +IY ++ N +G K G P + ++P+ G Sbjct: 192 YLRIYLIAKR----------------------SNRRGPRAKGG---PGQGESKQPRPDHG 226 Query: 270 GSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHG 329 G++ + K P + S REV+ + + + +R A+ S Sbjct: 227 GALASA--------KLPALASVASAREVNGHSKSTGEKEEGETPEDTGTR---ALPPSWA 275 Query: 330 QLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPG----------------- 372 L QG G S + + + + + + P Sbjct: 276 ALPNSGQG-QKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSR 334 Query: 373 -----KGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILC 427 +G++ G G I W R R+ + RE++ L ++ F+LC Sbjct: 335 VLATLRGQVLLGRGVGA--IGGQWWRRRA---------QLTREKRFTFVLAVVIGVFVLC 383 Query: 428 WIPYFIFFMVIAFC-KNCCNEH-LHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL 483 W P+F + + A C K+C H L F W+GY NS+LNP+IY + N++F++ F+RIL Sbjct: 384 WFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 441 >gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sapiens] Length = 365 Score = 126 bits (316), Expect = 5e-29 Identities = 80/241 (33%), Positives = 123/241 (51%), Gaps = 13/241 (5%) Query: 6 SSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLY 65 ++C E M KT + +VV++T+ T LNL V+ A+ + +KLH N Sbjct: 4 TNCTTEASMAIRPKTITEKMLICMTLVVITTL---TTLLNLAVIMAIGTTKKLHQPANYL 60 Query: 66 IVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDR 125 I SL+V DL+V +VMP++I+Y++M +W LG LC WLS+D T SI + ++ +DR Sbjct: 61 ICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDR 120 Query: 126 YRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFY 185 Y ++ + Y + RT RA+ IL W +S +P L W + + + + D Sbjct: 121 YWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHV 180 Query: 186 DVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQ----HRELINRSLP---SFSEIK 238 T + + A FY+P L+L Y +IY A + Q R L NRS SF+ K Sbjct: 181 IYTIYSTLGA---FYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCK 237 Query: 239 L 239 L Sbjct: 238 L 238 Score = 79.7 bits (195), Expect = 5e-15 Identities = 38/88 (43%), Positives = 55/88 (62%), Gaps = 3/88 (3%) Query: 399 RQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGY 458 RQ +S RERKAA+ LG I+ AFIL W+P+FI +++ + + F WLGY Sbjct: 278 RQQISS---TRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGY 334 Query: 459 INSTLNPLIYPLCNENFKKTFKRILHIR 486 +NS +NPL+Y NE+FK FK+++ R Sbjct: 335 VNSLINPLLYTSFNEDFKLAFKKLIRCR 362 >gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sapiens] Length = 390 Score = 122 bits (306), Expect = 7e-28 Identities = 75/243 (30%), Positives = 124/243 (51%), Gaps = 8/243 (3%) Query: 2 SLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTV 61 S P+ +C +D + + + ++ P + LV++L+ I L T N V+ V RKLHT Sbjct: 27 SAPSQNCSAKDYIYQDS---ISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTP 83 Query: 62 GNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFIL 121 N I SL+V DL+V +VMP++ +Y + +W+LG+ +C FWLS D TASI + ++ Sbjct: 84 ANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVI 143 Query: 122 CIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCE 181 +DRY ++ + Y RT RA+ I W S +P W + V +C Sbjct: 144 ALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEV---SECV 200 Query: 182 TDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRP 241 + D + V + + FY PTLL++ Y +IY R ++ NR+ + +L Sbjct: 201 VN-TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL-KQTPNRTGKRLTRAQLIT 258 Query: 242 ENP 244 ++P Sbjct: 259 DSP 261 Score = 92.8 bits (229), Expect = 6e-19 Identities = 39/80 (48%), Positives = 57/80 (71%), Gaps = 2/80 (2%) Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTI--WLGYINSTLNPL 466 RERKA K LG I+ AFI+CW+P+FI +V+ CK+ C HL +F WLGY+NS +NP+ Sbjct: 308 RERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPI 367 Query: 467 IYPLCNENFKKTFKRILHIR 486 IY + NE+FK+ F +++ + Sbjct: 368 IYTMSNEDFKQAFHKLIRFK 387 >gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] Length = 397 Score = 121 bits (304), Expect = 1e-27 Identities = 70/199 (35%), Positives = 114/199 (57%), Gaps = 11/199 (5%) Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89 + VVL+ + L+TV N++V AV R+L + N +IVSL++ DL++G +V+P + +Y L Sbjct: 21 ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80 Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149 KWS G+ C + S+D + TASI ++F++ +DRY +V PLRY T R + +++ Sbjct: 81 SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140 Query: 150 GAWF----LSFLWVIPILGWNHFMQQTSV--RREDKCETDFYDVTWFKVMTAIINFYLPT 203 W LSFL + LGWN +TS KC+ +V + ++ ++ FYLP Sbjct: 141 LIWVISITLSFLSI--HLGWNS-RNETSKGNHTTSKCKVQVNEV--YGLVDGLVTFYLPL 195 Query: 204 LLMLWFYAKIYKAVRQHCQ 222 L+M Y +I+K R + Sbjct: 196 LIMCITYYRIFKVARDQAK 214 Score = 66.6 bits (161), Expect = 5e-11 Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 1/79 (1%) Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFC-KNCCNEHLHMFTIWLGYINSTLNPLI 467 RE KA L +M AFI+CW PYF F+ + NE L +WLGY NS LNP++ Sbjct: 228 REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPIL 287 Query: 468 YPLCNENFKKTFKRILHIR 486 Y N +F+ ++++ R Sbjct: 288 YAALNRDFRTGYQQLFCCR 306 >gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] Length = 359 Score = 121 bits (304), Expect = 1e-27 Identities = 70/199 (35%), Positives = 114/199 (57%), Gaps = 11/199 (5%) Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89 + VVL+ + L+TV N++V AV R+L + N +IVSL++ DL++G +V+P + +Y L Sbjct: 21 ITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL 80 Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149 KWS G+ C + S+D + TASI ++F++ +DRY +V PLRY T R + +++ Sbjct: 81 SCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLV 140 Query: 150 GAWF----LSFLWVIPILGWNHFMQQTSV--RREDKCETDFYDVTWFKVMTAIINFYLPT 203 W LSFL + LGWN +TS KC+ +V + ++ ++ FYLP Sbjct: 141 LIWVISITLSFLSI--HLGWNS-RNETSKGNHTTSKCKVQVNEV--YGLVDGLVTFYLPL 195 Query: 204 LLMLWFYAKIYKAVRQHCQ 222 L+M Y +I+K R + Sbjct: 196 LIMCITYYRIFKVARDQAK 214 Score = 66.6 bits (161), Expect = 5e-11 Identities = 31/79 (39%), Positives = 44/79 (55%), Gaps = 1/79 (1%) Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFC-KNCCNEHLHMFTIWLGYINSTLNPLI 467 RE KA L +M AFI+CW PYF F+ + NE L +WLGY NS LNP++ Sbjct: 228 REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPIL 287 Query: 468 YPLCNENFKKTFKRILHIR 486 Y N +F+ ++++ R Sbjct: 288 YAALNRDFRTGYQQLFCCR 306 >gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] Length = 413 Score = 119 bits (297), Expect = 8e-27 Identities = 62/195 (31%), Positives = 112/195 (57%), Gaps = 5/195 (2%) Query: 32 VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91 +V+S I L V N+LV+ A+ +L TV N +I SL+ ADL++G V+P ++LM Sbjct: 38 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK 97 Query: 92 KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151 W+ G C FW S+D + TASI ++ ++ +DRY ++ P +Y TK +A IL Sbjct: 98 MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMV 157 Query: 152 WFLSFLW-VIPI-LGWNHFMQQTSVR--REDKCETDFYDVTWFKVMTAIINFYLPTLLML 207 W +S L +PI + W Q ++ + C DF+ + + ++I++FY+P ++M+ Sbjct: 158 WIVSGLTSFLPIQMHWYRATHQEAINCYANETC-CDFFTNQAYAIASSIVSFYVPLVIMV 216 Query: 208 WFYAKIYKAVRQHCQ 222 + Y+++++ ++ Q Sbjct: 217 FVYSRVFQEAKRQLQ 231 Score = 66.2 bits (160), Expect = 6e-11 Identities = 31/78 (39%), Positives = 47/78 (60%), Gaps = 1/78 (1%) Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIY 468 +E KA K LG IM F LCW+P+FI +V N + +++ W+GY+NS NPLIY Sbjct: 267 KEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 326 Query: 469 PLCNENFKKTFKRILHIR 486 + +F+ F+ +L +R Sbjct: 327 -CRSPDFRIAFQELLCLR 343 >gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sapiens] Length = 377 Score = 118 bits (296), Expect = 1e-26 Identities = 68/189 (35%), Positives = 99/189 (52%), Gaps = 4/189 (2%) Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89 L VVLS I L TV N VL + RKLHT N I SL+ DL+V +VMP++I Y + Sbjct: 41 LAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTI 100 Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149 W+ G+ LC WLS D TASI + ++ +DRY ++ L Y K RT A+ I Sbjct: 101 THTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160 Query: 150 GAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWF 209 W +S IP L W Q + C + ++ + + + FY+P++L++ Sbjct: 161 IVWAISICISIPPLFWRQAKAQEEM---SDCLVNTSQIS-YTIYSTCGAFYIPSVLLIIL 216 Query: 210 YAKIYKAVR 218 Y +IY+A R Sbjct: 217 YGRIYRAAR 225 Score = 87.8 bits (216), Expect = 2e-17 Identities = 38/80 (47%), Positives = 56/80 (70%), Gaps = 2/80 (2%) Query: 409 RERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEH--LHMFTIWLGYINSTLNPL 466 RERKA K LG I+ AFI+CW+P+F+ +V+ C++ C H L F WLGY+NS +NP+ Sbjct: 295 RERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPI 354 Query: 467 IYPLCNENFKKTFKRILHIR 486 IY + NE F++ F++I+ R Sbjct: 355 IYTVFNEEFRQAFQKIVPFR 374 >gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sapiens] Length = 366 Score = 118 bits (295), Expect = 1e-26 Identities = 67/194 (34%), Positives = 104/194 (53%), Gaps = 5/194 (2%) Query: 25 PQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMN 84 P + + + LS + L+T +N LV+ A+ RKLH N I SL+V D +V +VMP + Sbjct: 21 PSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFS 80 Query: 85 ILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRA 144 I+Y++ W +G+ +C WLS+D T SI + + +DRYR++ + Y + RT A Sbjct: 81 IVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHA 140 Query: 145 SATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 I W +S +P L W H Q TS R+D+C +D + + FY+P Sbjct: 141 GIMITIVWIISVFISMPPLFWRH--QGTS--RDDECIIK-HDHIVSTIYSTFGAFYIPLA 195 Query: 205 LMLWFYAKIYKAVR 218 L+L Y KIY+A + Sbjct: 196 LILILYYKIYRAAK 209 Score = 101 bits (252), Expect = 1e-21 Identities = 58/152 (38%), Positives = 86/152 (56%), Gaps = 11/152 (7%) Query: 343 ASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSH----- 397 AS I+++++ G S S + T+ K S +T D I T + LRS Sbjct: 217 ASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEK 276 Query: 398 --SRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNC-CNEHLHMFTI 454 RQ +SG RERKAA LG I+ AF++CW+P+F+ +V+ C C +E + F Sbjct: 277 SWRRQKISG---TRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLA 333 Query: 455 WLGYINSTLNPLIYPLCNENFKKTFKRILHIR 486 WLGY+NS +NPLIY + NE+FKK F++++ R Sbjct: 334 WLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365 >gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sapiens] Length = 422 Score = 114 bits (284), Expect = 3e-25 Identities = 65/191 (34%), Positives = 106/191 (55%), Gaps = 12/191 (6%) Query: 32 VVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS 91 ++L T+ V N V+ A+ ER L V N I SL+V DL+V +V+PM LY +++ Sbjct: 41 LLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN 100 Query: 92 KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGA 151 KW+LG+ C ++++D + T+SI + + +DRY ++ P+ Y+ RT RA+A I Sbjct: 101 KWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT 160 Query: 152 WFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVT---WFKVMTAIINFYLPTLLML 207 W + FL I P+LGW ED+ + D ++ + + + FY+P LLML Sbjct: 161 WLIGFLISIPPMLGWR--------TPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLML 212 Query: 208 WFYAKIYKAVR 218 Y +I++A R Sbjct: 213 VLYGRIFRAAR 223 Score = 84.3 bits (207), Expect = 2e-16 Identities = 41/100 (41%), Positives = 61/100 (61%), Gaps = 10/100 (10%) Query: 390 TWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHL 449 +++R + + + + RERK K LG IM FILCW+P+FI +V+ FC++ C Sbjct: 320 SFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSC---- 375 Query: 450 HMFTI------WLGYINSTLNPLIYPLCNENFKKTFKRIL 483 HM T+ WLGY NS LNP+IY N++F+ FK+I+ Sbjct: 376 HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKII 415 >gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] Length = 455 Score = 113 bits (282), Expect = 4e-25 Identities = 64/191 (33%), Positives = 108/191 (56%), Gaps = 7/191 (3%) Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89 L V+L + L V N+LV+ +V R LH+V + YIV+L+VADL++ + V+P + ++ + Sbjct: 29 LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88 Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149 + W+ GR C W ++D + TASI + I+ IDRY V PLRY T+ R +L Sbjct: 89 LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148 Query: 150 GAWFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLW 208 W LS + I P+ GW +Q + E C+ + + + + +A+ +FYLP ++L Sbjct: 149 CVWALSLVISIGPLFGW----RQPAPEDETICQIN--EEPGYVLFSALGSFYLPLAIILV 202 Query: 209 FYAKIYKAVRQ 219 Y ++Y ++ Sbjct: 203 MYCRVYVVAKR 213 Score = 80.5 bits (197), Expect = 3e-15 Identities = 34/83 (40%), Positives = 55/83 (66%), Gaps = 1/83 (1%) Query: 405 LHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCC-NEHLHMFTIWLGYINSTL 463 L +RE+KAAK LG ++ F+LCW+P+F+ + +F + +E + WLGY+NS + Sbjct: 262 LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321 Query: 464 NPLIYPLCNENFKKTFKRILHIR 486 NP+IYP ++ FKK F+ +L I+ Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344 >gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] Length = 466 Score = 113 bits (282), Expect = 4e-25 Identities = 64/191 (33%), Positives = 108/191 (56%), Gaps = 7/191 (3%) Query: 30 LVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLL 89 L V+L + L V N+LV+ +V R LH+V + YIV+L+VADL++ + V+P + ++ + Sbjct: 29 LGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEV 88 Query: 90 MSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATIL 149 + W+ GR C W ++D + TASI + I+ IDRY V PLRY T+ R +L Sbjct: 89 LGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALL 148 Query: 150 GAWFLSFLWVI-PILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLW 208 W LS + I P+ GW +Q + E C+ + + + + +A+ +FYLP ++L Sbjct: 149 CVWALSLVISIGPLFGW----RQPAPEDETICQIN--EEPGYVLFSALGSFYLPLAIILV 202 Query: 209 FYAKIYKAVRQ 219 Y ++Y ++ Sbjct: 203 MYCRVYVVAKR 213 Score = 80.5 bits (197), Expect = 3e-15 Identities = 34/83 (40%), Positives = 55/83 (66%), Gaps = 1/83 (1%) Query: 405 LHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCC-NEHLHMFTIWLGYINSTL 463 L +RE+KAAK LG ++ F+LCW+P+F+ + +F + +E + WLGY+NS + Sbjct: 262 LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCI 321 Query: 464 NPLIYPLCNENFKKTFKRILHIR 486 NP+IYP ++ FKK F+ +L I+ Sbjct: 322 NPIIYPCSSQEFKKAFQNVLRIQ 344 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.324 0.136 0.425 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,241,017 Number of Sequences: 37866 Number of extensions: 805950 Number of successful extensions: 4833 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 549 Number of HSP's successfully gapped in prelim test: 212 Number of HSP's that attempted gapping in prelim test: 3151 Number of HSP's gapped (non-prelim): 1423 length of query: 487 length of database: 18,247,518 effective HSP length: 106 effective length of query: 381 effective length of database: 14,233,722 effective search space: 5423048082 effective search space used: 5423048082 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.