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Search of human proteins with 148839372
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148839372 thioredoxin domain containing 3 [Homo sapiens]
(588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148839372 thioredoxin domain containing 3 [Homo sapiens] 1164 0.0
gi|37574614 nucleoside diphosphate kinase 7 isoform b [Homo sapi... 144 3e-34
gi|7019465 nucleoside diphosphate kinase 7 isoform a [Homo sapiens] 144 3e-34
gi|30023828 thioredoxin domain containing 6 [Homo sapiens] 121 2e-27
gi|4505413 non-metastatic cells 5, protein expressed in (nucleos... 91 2e-18
gi|5031951 nucleoside diphosphate kinase type 6 [Homo sapiens] 82 2e-15
gi|66392203 NME1-NME2 protein [Homo sapiens] 65 1e-10
gi|66392227 nucleoside diphosphate kinase B [Homo sapiens] 61 3e-09
gi|66392205 nucleoside diphosphate kinase B [Homo sapiens] 61 3e-09
gi|66392192 nucleoside diphosphate kinase B [Homo sapiens] 61 3e-09
gi|4505409 nucleoside diphosphate kinase B [Homo sapiens] 61 3e-09
gi|38045913 non-metastatic cells 1, protein (NM23A) expressed in... 58 2e-08
gi|4557797 non-metastatic cells 1, protein (NM23A) expressed in ... 58 2e-08
gi|4826862 nucleoside diphosphate kinase 4 [Homo sapiens] 57 6e-08
gi|37693993 nucleoside diphosphate kinase 3 [Homo sapiens] 55 2e-07
gi|50592994 thioredoxin [Homo sapiens] 49 1e-05
gi|95113651 glutaredoxin 3 [Homo sapiens] 44 4e-04
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s... 41 0.004
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 40 0.005
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 40 0.006
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 40 0.006
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 40 0.006
gi|4758304 protein disulfide isomerase A4 [Homo sapiens] 37 0.051
gi|21361403 thioredoxin 2 precursor [Homo sapiens] 36 0.086
gi|217035164 coiled-coil domain containing 27 [Homo sapiens] 36 0.086
gi|153791839 sodium channel associated protein 1 [Homo sapiens] 36 0.086
gi|54633317 thioredoxin domain containing 11 [Homo sapiens] 36 0.086
gi|4759274 thioredoxin-like 1 [Homo sapiens] 36 0.11
gi|5031973 protein disulfide isomerase A6 [Homo sapiens] 33 0.56
gi|51477718 TATA box binding protein-associated factor, RNA poly... 33 0.56
>gi|148839372 thioredoxin domain containing 3 [Homo sapiens]
Length = 588
Score = 1164 bits (3012), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE 60
MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE
Sbjct: 1 MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE 60
Query: 61 ILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKI 120
ILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKI
Sbjct: 61 ILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKI 120
Query: 121 AAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKA 180
AAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKA
Sbjct: 121 AAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKA 180
Query: 181 GFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEET 240
GFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEET
Sbjct: 181 GFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEET 240
Query: 241 EPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFM 300
EPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFM
Sbjct: 241 EPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFM 300
Query: 301 DAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQA 360
DAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQA
Sbjct: 301 DAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQA 360
Query: 361 LCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQ 420
LCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQ
Sbjct: 361 LCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQ 420
Query: 421 FAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDL 480
FAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDL
Sbjct: 421 FAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDL 480
Query: 481 TQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD 540
TQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD
Sbjct: 481 TQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD 540
Query: 541 PEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN 588
PEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN
Sbjct: 541 PEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN 588
>gi|37574614 nucleoside diphosphate kinase 7 isoform b [Homo
sapiens]
Length = 340
Score = 144 bits (362), Expect = 3e-34
Identities = 88/266 (33%), Positives = 147/266 (55%), Gaps = 17/266 (6%)
Query: 316 EKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKLI 375
EKTLAL++P+ + +++ II F I + + ++LS KEA ++++ +FN+LI
Sbjct: 56 EKTLALIKPDAI-SKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELI 114
Query: 376 ENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSD 435
+ +T+GP +A+ +LRD+ + WK+LLGP A ES+ A F D + N +G D
Sbjct: 115 QFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIR-NAAHGPD 173
Query: 436 SLETAEREIQHFFPLQSTLG-------------LIKPHATSE-QREQILKIVKEAGFDLT 481
S +A RE++ FFP G ++KPHA SE +IL +++AGF+++
Sbjct: 174 SFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEIS 233
Query: 482 QVKKMFLTPEQIEKIYPKVTG-KDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD 540
++ + +E+ Y G Y D++ + GP + M + + NA +R GP D
Sbjct: 234 AMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPAD 293
Query: 541 PEEAKLLSPDSIRAQFGISKLKNIVH 566
PE A+ L P ++RA FG +K++N VH
Sbjct: 294 PEIARHLRPGTLRAIFGKTKIQNAVH 319
Score = 84.0 bits (206), Expect = 4e-16
Identities = 42/132 (31%), Positives = 77/132 (58%), Gaps = 1/132 (0%)
Query: 451 QSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLL 510
+ TL LIKP A S+ E I++I+ +AGF +T++K M L+ ++ + + F+ +L+
Sbjct: 56 EKTLALIKPDAISKAGE-IIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELI 114
Query: 511 EMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASN 570
+ ++ GP + M + + +A+ EW+RL+GP + A+ + +SIRA FG ++N HG +
Sbjct: 115 QFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDS 174
Query: 571 AYEAKEVVNRLF 582
A + F
Sbjct: 175 FASAAREMELFF 186
Score = 59.3 bits (142), Expect = 1e-08
Identities = 63/307 (20%), Positives = 125/307 (40%), Gaps = 39/307 (12%)
Query: 156 SIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVS 215
++A+IKPDA+ K EI I KAGF I +L+ ++ ++F+ + F E +
Sbjct: 58 TLALIKPDAI--SKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQ 115
Query: 216 FMTSGLSYIL------VVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKN 269
F+T+G + + + + P+ +TD
Sbjct: 116 FITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDA----------------------- 152
Query: 270 KQDSLQEYLERQHLAQLCDIEEDAANVAKFMDAFFPDFKKMKSMKLEK----TLALLRPN 325
+S++ + + A+ A+ M+ FFP K T +++P+
Sbjct: 153 -SESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPH 211
Query: 326 LFHE-RKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYEN-EDYFNKLIENMTSGPS 383
E +L I+D F+I + + + + Y+ ++ ++ M SGP
Sbjct: 212 AVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPC 271
Query: 384 LALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSDSLETAERE 443
+A+ + ++N + +++ GP E A P +L A F + N ++ +D E E
Sbjct: 272 VAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQ-NAVHCTDLPEDGLLE 330
Query: 444 IQHFFPL 450
+Q+FF +
Sbjct: 331 VQYFFKI 337
>gi|7019465 nucleoside diphosphate kinase 7 isoform a [Homo sapiens]
Length = 376
Score = 144 bits (362), Expect = 3e-34
Identities = 88/266 (33%), Positives = 147/266 (55%), Gaps = 17/266 (6%)
Query: 316 EKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKLI 375
EKTLAL++P+ + +++ II F I + + ++LS KEA ++++ +FN+LI
Sbjct: 92 EKTLALIKPDAI-SKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELI 150
Query: 376 ENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSD 435
+ +T+GP +A+ +LRD+ + WK+LLGP A ES+ A F D + N +G D
Sbjct: 151 QFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIR-NAAHGPD 209
Query: 436 SLETAEREIQHFFPLQSTLG-------------LIKPHATSE-QREQILKIVKEAGFDLT 481
S +A RE++ FFP G ++KPHA SE +IL +++AGF+++
Sbjct: 210 SFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPHAVSEGLLGKILMAIRDAGFEIS 269
Query: 482 QVKKMFLTPEQIEKIYPKVTG-KDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTD 540
++ + +E+ Y G Y D++ + GP + M + + NA +R GP D
Sbjct: 270 AMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNATKTFREFCGPAD 329
Query: 541 PEEAKLLSPDSIRAQFGISKLKNIVH 566
PE A+ L P ++RA FG +K++N VH
Sbjct: 330 PEIARHLRPGTLRAIFGKTKIQNAVH 355
Score = 84.0 bits (206), Expect = 4e-16
Identities = 42/132 (31%), Positives = 77/132 (58%), Gaps = 1/132 (0%)
Query: 451 QSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLL 510
+ TL LIKP A S+ E I++I+ +AGF +T++K M L+ ++ + + F+ +L+
Sbjct: 92 EKTLALIKPDAISKAGE-IIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELI 150
Query: 511 EMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASN 570
+ ++ GP + M + + +A+ EW+RL+GP + A+ + +SIRA FG ++N HG +
Sbjct: 151 QFITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDS 210
Query: 571 AYEAKEVVNRLF 582
A + F
Sbjct: 211 FASAAREMELFF 222
Score = 59.3 bits (142), Expect = 1e-08
Identities = 63/307 (20%), Positives = 125/307 (40%), Gaps = 39/307 (12%)
Query: 156 SIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVS 215
++A+IKPDA+ K EI I KAGF I +L+ ++ ++F+ + F E +
Sbjct: 94 TLALIKPDAI--SKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQ 151
Query: 216 FMTSGLSYIL------VVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKN 269
F+T+G + + + + P+ +TD
Sbjct: 152 FITTGPIIAMEILRDDAICEWKRLLGPANSGVARTDA----------------------- 188
Query: 270 KQDSLQEYLERQHLAQLCDIEEDAANVAKFMDAFFPDFKKMKSMKLEK----TLALLRPN 325
+S++ + + A+ A+ M+ FFP K T +++P+
Sbjct: 189 -SESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSSGGCGPANTAKFTNCTCCIVKPH 247
Query: 326 LFHE-RKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYEN-EDYFNKLIENMTSGPS 383
E +L I+D F+I + + + + Y+ ++ ++ M SGP
Sbjct: 248 AVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPC 307
Query: 384 LALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSDSLETAERE 443
+A+ + ++N + +++ GP E A P +L A F + N ++ +D E E
Sbjct: 308 VAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQ-NAVHCTDLPEDGLLE 366
Query: 444 IQHFFPL 450
+Q+FF +
Sbjct: 367 VQYFFKI 373
>gi|30023828 thioredoxin domain containing 6 [Homo sapiens]
Length = 263
Score = 121 bits (304), Expect = 2e-27
Identities = 85/237 (35%), Positives = 122/237 (51%), Gaps = 37/237 (15%)
Query: 23 MLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPFRDKC 82
ML +KGLTV+DVYQ WCGPC+ + LF+K++ E+ D +LHFA+AEAD + L+ +R KC
Sbjct: 1 MLSSKGLTVVDVYQGWCGPCKPVVSLFQKMRIEVGLD-LLHFALAEADRLDVLEKYRGKC 59
Query: 83 EPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKIAAGEMARPQYPEIPLVDSDSEV 142
EP FLF K L DE+ ++ G+ + + V
Sbjct: 60 EPTFLFYAI-----------------KDEALSDEDECVSHGKNNG---------EDEDMV 93
Query: 143 SEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYS 202
S E C ++AIIKPDAV K EI KI +AGF I + +TE +V FY
Sbjct: 94 SSERTC-------TLAIIKPDAVAHGKTDEIIMKIQEAGFEILTNEERTMTEAEVRLFYQ 146
Query: 203 RIADQCDFEEFVSFMTSGLSYILVV--SQGSKHNPPSEETEPQTDTEPNERSEDQPE 257
A + FE+ V M SG S++L++ ++G + + T +PN +QPE
Sbjct: 147 HKAGEEAFEKLVHHMCSGPSHLLILTRTEGFEDVVTTWRT-VMGPRDPNVARREQPE 202
Score = 82.4 bits (202), Expect = 1e-15
Identities = 48/145 (33%), Positives = 81/145 (55%), Gaps = 6/145 (4%)
Query: 310 MKSMKLEKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENE 368
M S + TLA+++P+ + H + D+++ I++ F+IL + ++E E + + E
Sbjct: 92 MVSSERTCTLAIIKPDAVAHGKTDEIIMKIQEAGFEILTNEERTMTEAEVRLFYQHKAGE 151
Query: 369 DYFNKLIENMTSGPSLALVLLRDNGLQ----YWKQLLGPRTVEEAIEYFPESLCAQFAMD 424
+ F KL+ +M SGPS L+L R G + W+ ++GPR A PESL AQ+ +
Sbjct: 152 EAFEKLVHHMCSGPSHLLILTRTEGFEDVVTTWRTVMGPRDPNVARREQPESLRAQYGTE 211
Query: 425 SLPVNQLYGSDSLETAEREIQHFFP 449
+P N ++GS E A+RE+ FP
Sbjct: 212 -MPFNAVHGSRDREDADRELALLFP 235
Score = 80.5 bits (197), Expect = 4e-15
Identities = 43/135 (31%), Positives = 77/135 (57%), Gaps = 5/135 (3%)
Query: 453 TLGLIKPHATSEQR-EQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLE 511
TL +IKP A + + ++I+ ++EAGF++ ++ +T ++ Y G++ ++ L+
Sbjct: 100 TLAIIKPDAVAHGKTDEIIMKIQEAGFEILTNEERTMTEAEVRLFYQHKAGEEAFEKLVH 159
Query: 512 MLSVGPSMVMILTKW----NAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHG 567
+ GPS ++ILT+ + V WR +MGP DP A+ P+S+RAQ+G N VHG
Sbjct: 160 HMCSGPSHLLILTRTEGFEDVVTTWRTVMGPRDPNVARREQPESLRAQYGTEMPFNAVHG 219
Query: 568 ASNAYEAKEVVNRLF 582
+ + +A + LF
Sbjct: 220 SRDREDADRELALLF 234
>gi|4505413 non-metastatic cells 5, protein expressed in
(nucleoside-diphosphate kinase) [Homo sapiens]
Length = 212
Score = 91.3 bits (225), Expect = 2e-18
Identities = 46/135 (34%), Positives = 79/135 (58%), Gaps = 1/135 (0%)
Query: 450 LQSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDL 509
++ TL +IKP ++ E+I I+ +GF + Q +K+ L+PEQ Y + GK F+ +L
Sbjct: 12 VEKTLAIIKPDIVDKE-EEIQDIILRSGFTIVQRRKLRLSPEQCSNFYVEKYGKMFFPNL 70
Query: 510 LEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGAS 569
+S GP + MIL + A++ W L+GP + AK PDS+RA +G L+N +HG++
Sbjct: 71 TAYMSSGPLVAMILARHKAISYWLELLGPNNSLVAKETHPDSLRAIYGTDDLRNALHGSN 130
Query: 570 NAYEAKEVVNRLFED 584
+ A+ + +F +
Sbjct: 131 DFAAAEREIRFMFPE 145
Score = 85.5 bits (210), Expect = 1e-16
Identities = 48/135 (35%), Positives = 80/135 (59%), Gaps = 2/135 (1%)
Query: 315 LEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKL 374
+EKTLA+++P++ ++++++ II F I+++R++ LS ++ E + +F L
Sbjct: 12 VEKTLAIIKPDIV-DKEEEIQDIILRSGFTIVQRRKLRLSPEQCSNFYVEKYGKMFFPNL 70
Query: 375 IENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGS 434
M+SGP +A++L R + YW +LLGP A E P+SL A + D L N L+GS
Sbjct: 71 TAYMSSGPLVAMILARHKAISYWLELLGPNNSLVAKETHPDSLRAIYGTDDLR-NALHGS 129
Query: 435 DSLETAEREIQHFFP 449
+ AEREI+ FP
Sbjct: 130 NDFAAAEREIRFMFP 144
Score = 40.0 bits (92), Expect = 0.006
Identities = 28/89 (31%), Positives = 48/89 (53%), Gaps = 4/89 (4%)
Query: 141 EVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNF 200
E+S P V++ ++AIIKPD V ++ EI+ I ++GF I K L+ EQ NF
Sbjct: 2 EISMPPPQIYVEK--TLAIIKPDIVDKEE--EIQDIILRSGFTIVQRRKLRLSPEQCSNF 57
Query: 201 YSRIADQCDFEEFVSFMTSGLSYILVVSQ 229
Y + F ++M+SG +++++
Sbjct: 58 YVEKYGKMFFPNLTAYMSSGPLVAMILAR 86
>gi|5031951 nucleoside diphosphate kinase type 6 [Homo sapiens]
Length = 194
Score = 81.6 bits (200), Expect = 2e-15
Identities = 45/140 (32%), Positives = 74/140 (52%), Gaps = 2/140 (1%)
Query: 450 LQSTLGLIKPHATSEQR--EQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYK 507
LQ TL LIKP A + E + + + F + +++++ E ++ Y + G+ FY+
Sbjct: 19 LQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQ 78
Query: 508 DLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHG 567
L+E ++ GP IL +A+ WR LMGPT A+ ++PDSIR FG++ +N HG
Sbjct: 79 RLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHG 138
Query: 568 ASNAYEAKEVVNRLFEDPEE 587
+ + A + F D E
Sbjct: 139 SDSVVSASREIAAFFPDFSE 158
Score = 76.3 bits (186), Expect = 8e-14
Identities = 44/137 (32%), Positives = 74/137 (54%), Gaps = 3/137 (2%)
Query: 315 LEKTLALLRPNLFHERK--DDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFN 372
L+ TLAL++P+ + V + I F I+ R+++ +++ Q +E+E ++
Sbjct: 19 LQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQ 78
Query: 373 KLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLY 432
+L+E M SGP A +L + +Q W+ L+GP V A P+S+ F + N +
Sbjct: 79 RLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTR-NTTH 137
Query: 433 GSDSLETAEREIQHFFP 449
GSDS+ +A REI FFP
Sbjct: 138 GSDSVVSASREIAAFFP 154
Score = 35.0 bits (79), Expect = 0.19
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 3/73 (4%)
Query: 156 SIAIIKPDAVISKKVLE-IKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFV 214
++A+IKPDAV +LE + ++I F+I + + +E FY + ++ V
Sbjct: 22 TLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLV 81
Query: 215 SFMTSG--LSYIL 225
FM SG +YIL
Sbjct: 82 EFMASGPIRAYIL 94
>gi|66392203 NME1-NME2 protein [Homo sapiens]
Length = 267
Score = 65.5 bits (158), Expect = 1e-10
Identities = 60/274 (21%), Positives = 127/274 (46%), Gaps = 27/274 (9%)
Query: 316 EKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKL 374
E+T ++P+ + ++++ + + F+++ + + SE + + ++ +F L
Sbjct: 5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGL 64
Query: 375 IENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGS 434
++ M SGP +A+V N ++ + +LG DS P + G
Sbjct: 65 VKYMHSGPVVAMVWEGLNVVKTGRVMLGETN----------------PADSKP-GTIRGD 107
Query: 435 DSLETAEREIQHFFPLQSTLGLIKPHATSEQRE-QILKIVKEAGFDLTQVKKMFLTPEQI 493
++ L+ T IKP +I+K ++ GF L +K + + E +
Sbjct: 108 FCIQVGRTMAN----LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHL 163
Query: 494 EKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIR 553
++ Y + + F+ L++ ++ GP + M+ N V R ++G T+P ++K P +IR
Sbjct: 164 KQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSK---PGTIR 220
Query: 554 AQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEE 587
F I +NI+HG+ + A++ ++ F+ PEE
Sbjct: 221 GDFCIQVGRNIIHGSDSVKSAEKEISLWFK-PEE 253
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/135 (22%), Positives = 73/135 (54%), Gaps = 5/135 (3%)
Query: 315 LEKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNK 373
LE+T ++P+ + ++++ + + F+++ + + SE+ + + ++ +F
Sbjct: 119 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 178
Query: 374 LIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYG 433
L++ M SGP +A+V N ++ + +LG ++ P ++ F + + N ++G
Sbjct: 179 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADS---KPGTIRGDFCI-QVGRNIIHG 234
Query: 434 SDSLETAEREIQHFF 448
SDS+++AE+EI +F
Sbjct: 235 SDSVKSAEKEISLWF 249
Score = 30.8 bits (68), Expect = 3.6
Identities = 20/61 (32%), Positives = 29/61 (47%)
Query: 160 IKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTS 219
IKPD V V EI ++ + GF + A +EE + Y + D+ F V +M S
Sbjct: 126 IKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNS 185
Query: 220 G 220
G
Sbjct: 186 G 186
>gi|66392227 nucleoside diphosphate kinase B [Homo sapiens]
Length = 152
Score = 61.2 bits (147), Expect = 3e-09
Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 5/139 (3%)
Query: 450 LQSTLGLIKPHATSEQRE-QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKD 508
L+ T IKP +I+K ++ GF L +K + + E +++ Y + + F+
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 509 LLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGA 568
L++ ++ GP + M+ N V R ++G T+P ++K P +IR F I +NI+HG+
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGS 120
Query: 569 SNAYEAKEVVNRLFEDPEE 587
+ A++ ++ F+ PEE
Sbjct: 121 DSVKSAEKEISLWFK-PEE 138
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/135 (22%), Positives = 73/135 (54%), Gaps = 5/135 (3%)
Query: 315 LEKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNK 373
LE+T ++P+ + ++++ + + F+++ + + SE+ + + ++ +F
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 374 LIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYG 433
L++ M SGP +A+V N ++ + +LG ++ P ++ F + + N ++G
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADS---KPGTIRGDFCI-QVGRNIIHG 119
Query: 434 SDSLETAEREIQHFF 448
SDS+++AE+EI +F
Sbjct: 120 SDSVKSAEKEISLWF 134
Score = 30.8 bits (68), Expect = 3.6
Identities = 20/61 (32%), Positives = 29/61 (47%)
Query: 160 IKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTS 219
IKPD V V EI ++ + GF + A +EE + Y + D+ F V +M S
Sbjct: 11 IKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNS 70
Query: 220 G 220
G
Sbjct: 71 G 71
>gi|66392205 nucleoside diphosphate kinase B [Homo sapiens]
Length = 152
Score = 61.2 bits (147), Expect = 3e-09
Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 5/139 (3%)
Query: 450 LQSTLGLIKPHATSEQRE-QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKD 508
L+ T IKP +I+K ++ GF L +K + + E +++ Y + + F+
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 509 LLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGA 568
L++ ++ GP + M+ N V R ++G T+P ++K P +IR F I +NI+HG+
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGS 120
Query: 569 SNAYEAKEVVNRLFEDPEE 587
+ A++ ++ F+ PEE
Sbjct: 121 DSVKSAEKEISLWFK-PEE 138
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/135 (22%), Positives = 73/135 (54%), Gaps = 5/135 (3%)
Query: 315 LEKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNK 373
LE+T ++P+ + ++++ + + F+++ + + SE+ + + ++ +F
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 374 LIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYG 433
L++ M SGP +A+V N ++ + +LG ++ P ++ F + + N ++G
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADS---KPGTIRGDFCI-QVGRNIIHG 119
Query: 434 SDSLETAEREIQHFF 448
SDS+++AE+EI +F
Sbjct: 120 SDSVKSAEKEISLWF 134
Score = 30.8 bits (68), Expect = 3.6
Identities = 20/61 (32%), Positives = 29/61 (47%)
Query: 160 IKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTS 219
IKPD V V EI ++ + GF + A +EE + Y + D+ F V +M S
Sbjct: 11 IKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNS 70
Query: 220 G 220
G
Sbjct: 71 G 71
>gi|66392192 nucleoside diphosphate kinase B [Homo sapiens]
Length = 152
Score = 61.2 bits (147), Expect = 3e-09
Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 5/139 (3%)
Query: 450 LQSTLGLIKPHATSEQRE-QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKD 508
L+ T IKP +I+K ++ GF L +K + + E +++ Y + + F+
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 509 LLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGA 568
L++ ++ GP + M+ N V R ++G T+P ++K P +IR F I +NI+HG+
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGS 120
Query: 569 SNAYEAKEVVNRLFEDPEE 587
+ A++ ++ F+ PEE
Sbjct: 121 DSVKSAEKEISLWFK-PEE 138
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/135 (22%), Positives = 73/135 (54%), Gaps = 5/135 (3%)
Query: 315 LEKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNK 373
LE+T ++P+ + ++++ + + F+++ + + SE+ + + ++ +F
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 374 LIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYG 433
L++ M SGP +A+V N ++ + +LG ++ P ++ F + + N ++G
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADS---KPGTIRGDFCI-QVGRNIIHG 119
Query: 434 SDSLETAEREIQHFF 448
SDS+++AE+EI +F
Sbjct: 120 SDSVKSAEKEISLWF 134
Score = 30.8 bits (68), Expect = 3.6
Identities = 20/61 (32%), Positives = 29/61 (47%)
Query: 160 IKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTS 219
IKPD V V EI ++ + GF + A +EE + Y + D+ F V +M S
Sbjct: 11 IKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNS 70
Query: 220 G 220
G
Sbjct: 71 G 71
>gi|4505409 nucleoside diphosphate kinase B [Homo sapiens]
Length = 152
Score = 61.2 bits (147), Expect = 3e-09
Identities = 39/139 (28%), Positives = 74/139 (53%), Gaps = 5/139 (3%)
Query: 450 LQSTLGLIKPHATSEQRE-QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKD 508
L+ T IKP +I+K ++ GF L +K + + E +++ Y + + F+
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 509 LLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGA 568
L++ ++ GP + M+ N V R ++G T+P ++K P +IR F I +NI+HG+
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGS 120
Query: 569 SNAYEAKEVVNRLFEDPEE 587
+ A++ ++ F+ PEE
Sbjct: 121 DSVKSAEKEISLWFK-PEE 138
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/135 (22%), Positives = 73/135 (54%), Gaps = 5/135 (3%)
Query: 315 LEKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNK 373
LE+T ++P+ + ++++ + + F+++ + + SE+ + + ++ +F
Sbjct: 4 LERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPG 63
Query: 374 LIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYG 433
L++ M SGP +A+V N ++ + +LG ++ P ++ F + + N ++G
Sbjct: 64 LVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADS---KPGTIRGDFCI-QVGRNIIHG 119
Query: 434 SDSLETAEREIQHFF 448
SDS+++AE+EI +F
Sbjct: 120 SDSVKSAEKEISLWF 134
Score = 30.8 bits (68), Expect = 3.6
Identities = 20/61 (32%), Positives = 29/61 (47%)
Query: 160 IKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTS 219
IKPD V V EI ++ + GF + A +EE + Y + D+ F V +M S
Sbjct: 11 IKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNS 70
Query: 220 G 220
G
Sbjct: 71 G 71
>gi|38045913 non-metastatic cells 1, protein (NM23A) expressed in
isoform a [Homo sapiens]
Length = 177
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/120 (28%), Positives = 65/120 (54%), Gaps = 4/120 (3%)
Query: 468 QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWN 527
+I+K ++ GF L +K M + + +++ Y + + F+ L++ + GP + M+ N
Sbjct: 48 EIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLN 107
Query: 528 AVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEE 587
V R ++G T+P ++K P +IR F I +NI+HG+ + A++ + F PEE
Sbjct: 108 VVKTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFH-PEE 163
Score = 37.7 bits (86), Expect = 0.030
Identities = 30/134 (22%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 316 EKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKL 374
E+T ++P+ + ++++ + + F+++ + + SE + + ++ +F L
Sbjct: 30 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGL 89
Query: 375 IENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGS 434
++ M SGP +A+V N ++ + +LG ++ P ++ F + + N ++GS
Sbjct: 90 VKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSK---PGTIRGDFCIQ-VGRNIIHGS 145
Query: 435 DSLETAEREIQHFF 448
DS+E+AE+EI +F
Sbjct: 146 DSVESAEKEIGLWF 159
>gi|4557797 non-metastatic cells 1, protein (NM23A) expressed in
isoform b [Homo sapiens]
Length = 152
Score = 58.2 bits (139), Expect = 2e-08
Identities = 34/120 (28%), Positives = 65/120 (54%), Gaps = 4/120 (3%)
Query: 468 QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWN 527
+I+K ++ GF L +K M + + +++ Y + + F+ L++ + GP + M+ N
Sbjct: 23 EIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLN 82
Query: 528 AVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEE 587
V R ++G T+P ++K P +IR F I +NI+HG+ + A++ + F PEE
Sbjct: 83 VVKTGRVMLGETNPADSK---PGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFH-PEE 138
Score = 37.7 bits (86), Expect = 0.030
Identities = 30/134 (22%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 316 EKTLALLRPN-LFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKL 374
E+T ++P+ + ++++ + + F+++ + + SE + + ++ +F L
Sbjct: 5 ERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGL 64
Query: 375 IENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGS 434
++ M SGP +A+V N ++ + +LG ++ P ++ F + + N ++GS
Sbjct: 65 VKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSK---PGTIRGDFCIQ-VGRNIIHGS 120
Query: 435 DSLETAEREIQHFF 448
DS+E+AE+EI +F
Sbjct: 121 DSVESAEKEIGLWF 134
>gi|4826862 nucleoside diphosphate kinase 4 [Homo sapiens]
Length = 187
Score = 56.6 bits (135), Expect = 6e-08
Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 4/137 (2%)
Query: 451 QSTLGLIKPHATSEQRE-QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDL 509
+ TL +KP + +++ + GF L +K + + + Y + K FY L
Sbjct: 38 ERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPAL 97
Query: 510 LEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGAS 569
+ +S GP + M+ +N V R ++G TD EA +P +IR F + +N++H +
Sbjct: 98 IRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEA---APGTIRGDFSVHISRNVIHASD 154
Query: 570 NAYEAKEVVNRLFEDPE 586
+ A+ + F+ E
Sbjct: 155 SVEGAQREIQLWFQSSE 171
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/134 (25%), Positives = 68/134 (50%), Gaps = 5/134 (3%)
Query: 316 EKTLALLRPNLFHERK-DDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKL 374
E+TL ++P+ R DV++ + F ++ + + E ++ + ++ L
Sbjct: 38 ERTLVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPAL 97
Query: 375 IENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGS 434
I M+SGP +A+V N ++ + ++G EA P ++ F++ + N ++ S
Sbjct: 98 IRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA---PGTIRGDFSVH-ISRNVIHAS 153
Query: 435 DSLETAEREIQHFF 448
DS+E A+REIQ +F
Sbjct: 154 DSVEGAQREIQLWF 167
>gi|37693993 nucleoside diphosphate kinase 3 [Homo sapiens]
Length = 169
Score = 54.7 bits (130), Expect = 2e-07
Identities = 32/119 (26%), Positives = 61/119 (51%), Gaps = 3/119 (2%)
Query: 468 QILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWN 527
+I++ + GF L +K + + E + + Y ++ + FY L++ ++ GP + M+ +
Sbjct: 40 EIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLD 99
Query: 528 AVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPE 586
V R L+G T+P +A P +IR F I KN++HG+ + A+ + F E
Sbjct: 100 VVRTSRALIGATNPADA---PPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADE 155
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/134 (25%), Positives = 71/134 (52%), Gaps = 5/134 (3%)
Query: 316 EKTLALLRPNLFHERK-DDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKL 374
E+T ++P+ R +++R + + FK++ + V SE+ + E ++ +L
Sbjct: 22 ERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRERPFYGRL 81
Query: 375 IENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGS 434
++ M SGP +A+V + ++ + L+G +A P ++ F ++ + N ++GS
Sbjct: 82 VKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAP---PGTIRGDFCIE-VGKNLIHGS 137
Query: 435 DSLETAEREIQHFF 448
DS+E+A REI +F
Sbjct: 138 DSVESARREIALWF 151
Score = 33.9 bits (76), Expect = 0.43
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 148 CESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQ 207
C E +A+ KPD V + V EI R+ + GF + A +EE + Y+ + ++
Sbjct: 17 CTGAHERTFLAV-KPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYAELRER 75
Query: 208 CDFEEFVSFMTSGLSYILVVSQG 230
+ V +M SG + +V QG
Sbjct: 76 PFYGRLVKYMASG-PVVAMVWQG 97
>gi|50592994 thioredoxin [Homo sapiens]
Length = 105
Score = 48.9 bits (115), Expect = 1e-05
Identities = 27/103 (26%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 14 INNQSLWDEMLQNKG--LTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADN 71
I +++ + E L G L V+D WCGPC+ ++P F L + + L V + +
Sbjct: 5 IESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQD 64
Query: 72 IVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLI 114
+ + KC P F F G+ + + GAN + + L+
Sbjct: 65 VAS--ECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV 105
>gi|95113651 glutaredoxin 3 [Homo sapiens]
Length = 335
Score = 43.9 bits (102), Expect = 4e-04
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 4/88 (4%)
Query: 24 LQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTL-QPFRDKC 82
L+ K L V+ + W C M + +L EL + + F EA+ + + + +
Sbjct: 28 LKAKSLLVVHFWAPWAPQCAQMNEVMAELAKELPQ---VSFVKLEAEGVPEVSEKYEISS 84
Query: 83 EPVFLFSVNGKIIEKIQGANAPLVNKKV 110
P FLF N + I+++ GA+AP + KKV
Sbjct: 85 VPTFLFFKNSQKIDRLDGAHAPELTKKV 112
>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
sapiens]
Length = 793
Score = 40.8 bits (94), Expect = 0.004
Identities = 18/44 (40%), Positives = 25/44 (56%)
Query: 9 QLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKL 52
Q+ T + Q+ +++LQ K VID Y WCGPC+ P F L
Sbjct: 670 QVSTDLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELL 713
Score = 31.6 bits (70), Expect = 2.1
Identities = 11/26 (42%), Positives = 16/26 (61%)
Query: 31 VIDVYQAWCGPCRAMQPLFRKLKNEL 56
++D + WC PCRA+ P R+ N L
Sbjct: 472 LVDFFAPWCPPCRALLPELRRASNLL 497
Score = 29.6 bits (65), Expect = 8.1
Identities = 8/26 (30%), Positives = 16/26 (61%)
Query: 31 VIDVYQAWCGPCRAMQPLFRKLKNEL 56
++D Y WC PC+ + P ++++ L
Sbjct: 580 MVDFYSPWCHPCQVLMPEWKRMARTL 605
>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
Length = 505
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/75 (28%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Query: 20 WDEMLQNKGLTV-IDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPF 78
+DE++ N+ V I+ Y WCG C+ ++P +++L +L++D + A +A P+
Sbjct: 386 FDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPY 445
Query: 79 RDKCEPVFLFSVNGK 93
+ P FS K
Sbjct: 446 EVRGFPTIYFSPANK 460
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 40.0 bits (92), Expect = 0.006
Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 13 VINNQSLWDEMLQNKG--LTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEAD 70
VI ++ ++ L+ G L +D WCGPCR ++P F L + +ED + F +AD
Sbjct: 385 VILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK-HEDVV--FLEVDAD 441
Query: 71 NI-VTLQPFRDKCEPVFLFSVNGKIIEKIQGA 101
N ++ C P F F + ++++ GA
Sbjct: 442 NCEEVVRECAIMCVPTFQFYKKEEKVDELCGA 473
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 40.0 bits (92), Expect = 0.006
Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 13 VINNQSLWDEMLQNKG--LTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEAD 70
VI ++ ++ L+ G L +D WCGPCR ++P F L + +ED + F +AD
Sbjct: 452 VILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK-HEDVV--FLEVDAD 508
Query: 71 NI-VTLQPFRDKCEPVFLFSVNGKIIEKIQGA 101
N ++ C P F F + ++++ GA
Sbjct: 509 NCEEVVRECAIMCVPTFQFYKKEEKVDELCGA 540
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 40.0 bits (92), Expect = 0.006
Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 13 VINNQSLWDEMLQNKG--LTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEAD 70
VI ++ ++ L+ G L +D WCGPCR ++P F L + +ED + F +AD
Sbjct: 385 VILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVK-HEDVV--FLEVDAD 441
Query: 71 NI-VTLQPFRDKCEPVFLFSVNGKIIEKIQGA 101
N ++ C P F F + ++++ GA
Sbjct: 442 NCEEVVRECAIMCVPTFQFYKKEEKVDELCGA 473
>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
Length = 645
Score = 37.0 bits (84), Expect = 0.051
Identities = 12/47 (25%), Positives = 28/47 (59%)
Query: 12 TVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNE 58
T++ + +DE++ + + +++ Y WCG C+ + P + K EL++
Sbjct: 179 TLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSK 225
Score = 35.8 bits (81), Expect = 0.11
Identities = 12/48 (25%), Positives = 26/48 (54%)
Query: 13 VINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDE 60
++ N + +D + +K +++ Y WCG C+ P + K+ N L + +
Sbjct: 65 LVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKD 112
Score = 31.6 bits (70), Expect = 2.1
Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 1/63 (1%)
Query: 31 VIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEAD-NIVTLQPFRDKCEPVFLFS 89
+I+ Y WCG C+ ++P++ L + + L A +A N V ++ + P F+
Sbjct: 547 LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFA 606
Query: 90 VNG 92
+G
Sbjct: 607 PSG 609
>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
Length = 166
Score = 36.2 bits (82), Expect = 0.086
Identities = 19/81 (23%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 21 DEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQ-PFR 79
D ++ ++ V+D + WCGPC+ + P K+ + + ++ A + D+ L +
Sbjct: 72 DRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVM--AKVDIDDHTDLAIEYE 129
Query: 80 DKCEPVFLFSVNGKIIEKIQG 100
P L NG +++K G
Sbjct: 130 VSAVPTVLAMKNGDVVDKFVG 150
>gi|217035164 coiled-coil domain containing 27 [Homo sapiens]
Length = 656
Score = 36.2 bits (82), Expect = 0.086
Identities = 69/294 (23%), Positives = 110/294 (37%), Gaps = 55/294 (18%)
Query: 226 VVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQ 285
V GS H SEE E E +R ED E E + + + SL E E + LAQ
Sbjct: 359 VSQMGSVHEEGSEEEEE----EEGDRDEDSEERELPEEEEIPRRRASSLAESFEEELLAQ 414
Query: 286 LCDIEEDAANVAKFMDAFFP----------------DFKKMKSMK-------LEKTLALL 322
L + E+ + ++A DF++ + K L+K L
Sbjct: 415 LEEYEQVILDFQFNLEATRTRYSLATGVIASLQQQVDFQETQLRKINTENETLQKELRER 474
Query: 323 R----------PNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFN 372
R NL ++K + + ++D ++L Q+ L K + C E + +
Sbjct: 475 RQQLQAMTDKFSNLREDKKHQEMMGLIEKDNQLLRQQVSELERKLTKRDCVISELDTKVS 534
Query: 373 KLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLY 432
+L E V L N LQ WKQL +E ++ E + Q A V
Sbjct: 535 QLQEQ---------VELDQNHLQRWKQL------QEDLQSKKEMI--QQAEQHTRVALES 577
Query: 433 GSDSLETAERE-IQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKK 485
LE + IQ F + T L + ++ E + +I+ E Q+K+
Sbjct: 578 SQSRLERLRNKIIQATFSISGTKSLANEISDNDILEALQRIISERSDYYNQLKQ 631
>gi|153791839 sodium channel associated protein 1 [Homo sapiens]
Length = 688
Score = 36.2 bits (82), Expect = 0.086
Identities = 43/158 (27%), Positives = 73/158 (46%), Gaps = 22/158 (13%)
Query: 356 KEAQALCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPE 415
+E QA C E ENE Y ++ S + LL + LQ + LL + EE IE E
Sbjct: 313 RELQAKCNELENERY-EAIVRARNS-----MQLLEEANLQKSQALLEEKQKEEDIEKMKE 366
Query: 416 SLCAQFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKE 475
++ ++F D+ + +++ + +I S L + +E++ QI +++KE
Sbjct: 367 TV-SRFVQDATIRTKKEVANTKKQCNIQISRLTEELSALQM----ECAEKQGQIERVIKE 421
Query: 476 AGFDLTQVKKMFLTPEQIEKIYPKVTGKDF-YKDLLEM 512
KK E++EKIY + G + Y+ L EM
Sbjct: 422 --------KK--AVEEELEKIYREGRGNESDYRKLEEM 449
>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
Length = 958
Score = 36.2 bits (82), Expect = 0.086
Identities = 22/105 (20%), Positives = 44/105 (41%), Gaps = 1/105 (0%)
Query: 10 LQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEA 69
L T + + W+ +LQ + + ++ Y WCG C ++ +F +L L D + +
Sbjct: 664 LITEVTTDTFWEVVLQKQDVLLL-YYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDVS 722
Query: 70 DNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLI 114
N + + D+ V F N K + + P+ ++ I
Sbjct: 723 QNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFI 767
>gi|4759274 thioredoxin-like 1 [Homo sapiens]
Length = 289
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/82 (28%), Positives = 35/82 (42%), Gaps = 2/82 (2%)
Query: 29 LTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPFRDKCEPVFLF 88
L V+ CGPC + P F + N+ + L V + T P FLF
Sbjct: 24 LAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQG--TAATNNISATPTFLF 81
Query: 89 SVNGKIIEKIQGANAPLVNKKV 110
N I++ QGA+A + +K+
Sbjct: 82 FRNKVRIDQYQGADAVGLEEKI 103
>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
Length = 440
Score = 33.5 bits (75), Expect = 0.56
Identities = 13/49 (26%), Positives = 27/49 (55%), Gaps = 2/49 (4%)
Query: 22 EMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEAD 70
E++Q+ L +++ Y WCG C+ + P ++K L +++ +AD
Sbjct: 38 EVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDAD 84
Score = 31.6 bits (70), Expect = 2.1
Identities = 14/57 (24%), Positives = 31/57 (54%), Gaps = 4/57 (7%)
Query: 2 ASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNE 58
+SKK ++L + S +L ++ + +++ Y WCG C+ ++P + +E+ E
Sbjct: 157 SSKKDVIEL----TDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKE 209
>gi|51477718 TATA box binding protein-associated factor, RNA
polymerase II, Q [Homo sapiens]
Length = 462
Score = 33.5 bits (75), Expect = 0.56
Identities = 31/150 (20%), Positives = 68/150 (45%), Gaps = 17/150 (11%)
Query: 228 SQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLC 287
S +N E+ + + + E + ED+ + E + +D +EYLERQ A+
Sbjct: 326 SDSRSNNDDDEDEDDEDEDEDEDEDEDEDKEEEE---------EDCSEEYLERQLQAEFI 376
Query: 288 DIEEDAANVAKFMDAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRI----IKDEDF 343
+ + AN + + + +K K EK L ++ N +KD ++++ +K+
Sbjct: 377 ESGQYRAN--EGTSSIVMEIQKQIEKK-EKKLHKIQ-NKAQRQKDLIMKVENLTLKNHFQ 432
Query: 344 KILEQRQVVLSEKEAQALCKEYENEDYFNK 373
+LEQ ++ +K + + + + + + K
Sbjct: 433 SVLEQLELQEKQKNEKLISLQEQLQRFLKK 462
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,549,529
Number of Sequences: 37866
Number of extensions: 937420
Number of successful extensions: 3799
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 3657
Number of HSP's gapped (non-prelim): 143
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.