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Search of human proteins with 148806877
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148806877 ankyrin repeat and GTPase domain Arf GTPase
activating protein 11 [Homo sapiens]
(550 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 1111 0.0
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 984 0.0
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 978 0.0
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 977 0.0
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 970 0.0
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 969 0.0
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 961 0.0
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 959 0.0
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 853 0.0
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 828 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 592 e-169
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 478 e-135
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 466 e-131
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 342 7e-94
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 148 1e-35
gi|187608516 centaurin, beta 2 [Homo sapiens] 132 8e-31
gi|7661880 centaurin beta1 [Homo sapiens] 130 4e-30
gi|46094081 development and differentiation enhancing factor 1 [... 127 3e-29
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 120 2e-27
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 120 2e-27
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 120 2e-27
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 120 2e-27
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 120 2e-27
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 120 2e-27
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 119 5e-27
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 119 5e-27
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 118 1e-26
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 118 1e-26
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 112 1e-24
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 112 1e-24
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 1111 bits (2874), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT
Sbjct: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA
Sbjct: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP
Sbjct: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP
Sbjct: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ
Sbjct: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV
Sbjct: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI
Sbjct: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN
Sbjct: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
Query: 541 LQYGCPDECV 550
LQYGCPDECV
Sbjct: 541 LQYGCPDECV 550
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 984 bits (2543), Expect = 0.0
Identities = 497/550 (90%), Positives = 508/550 (92%), Gaps = 25/550 (4%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHITK RNGGGSLNNYSSSIP T
Sbjct: 162 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPST 221
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQED FSVPPTANTPTP+CK+SM WSNLFTSEKGS PDK RKA E+HADTIGSGRA
Sbjct: 222 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRA 281
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP
Sbjct: 282 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 341
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLATSACAPISSSKSNGLSKDM D GLGDSICFSPSISSTTSPKLN P
Sbjct: 342 GKWPSLATSACAPISSSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 392
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 393 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 436
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGN+HCVD ETQNPKWASLNLGV
Sbjct: 437 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGV 496
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS+
Sbjct: 497 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSV 556
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
+STREEKERWIRSKYE KLFLAPLPCTELSLGQHLLRATADEDL+TAILLLAHGSREEVN
Sbjct: 557 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVN 616
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 617 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 676
Query: 541 LQYGCPDECV 550
LQYGCPDECV
Sbjct: 677 LQYGCPDECV 686
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 978 bits (2527), Expect = 0.0
Identities = 493/550 (89%), Positives = 507/550 (92%), Gaps = 25/550 (4%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 139 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPST 198
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQED FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 199 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 258
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVP
Sbjct: 259 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVP 318
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLATSAC PIS+SKSNGLSKDM D GLGDSICFSPSISSTTSPKLN P
Sbjct: 319 GKWPSLATSACTPISTSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 369
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 370 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 413
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSCESSKSKSQLTSQS+AMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 414 AIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 473
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS
Sbjct: 474 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSE 533
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
+STREEKERWIRSKYE KLFLAPLPCTELSLGQ LLRATADEDL+TAILLLAHGSREEVN
Sbjct: 534 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVN 593
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 594 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 653
Query: 541 LQYGCPDECV 550
LQYGCPD+CV
Sbjct: 654 LQYGCPDKCV 663
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 977 bits (2525), Expect = 0.0
Identities = 494/550 (89%), Positives = 505/550 (91%), Gaps = 25/550 (4%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 139 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPST 198
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQED FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 199 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 258
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVP
Sbjct: 259 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVP 318
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLATSAC PISSSKSNGLSKDM D GLGDSICFSPSISSTTSPKLN P
Sbjct: 319 GKWPSLATSACTPISSSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 369
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 370 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 413
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 414 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 473
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIH SLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS
Sbjct: 474 LMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSE 533
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
+STREEKERWIRSKYE KLFLAPLPCTELSLGQ LL ATADEDL+TAILLLAHGSREEVN
Sbjct: 534 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVN 593
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 594 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 653
Query: 541 LQYGCPDECV 550
LQYGCPDECV
Sbjct: 654 LQYGCPDECV 663
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 970 bits (2507), Expect = 0.0
Identities = 490/550 (89%), Positives = 504/550 (91%), Gaps = 25/550 (4%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHITK RNGGGSLNNYSSSIP T
Sbjct: 139 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPST 198
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQED FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 199 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 258
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMK IHKKEIDL+TSTIKVP
Sbjct: 259 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKYIHKKEIDLQTSTIKVP 318
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLAT AC PISSSKS+GLSKDM D GLGDSICFSPSISSTT PKLN P
Sbjct: 319 GKWPSLATLACTPISSSKSDGLSKDM---------DTGLGDSICFSPSISSTTIPKLNPP 369
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 370 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 413
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 414 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 473
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQG+TKP+
Sbjct: 474 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGRTKPTE 533
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
+STREEKERWIRSKYE KLFLAPLPCTELSLGQ LLRATADEDL+TAILLLAHGSREEVN
Sbjct: 534 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVN 593
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 594 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 653
Query: 541 LQYGCPDECV 550
LQYGCPDECV
Sbjct: 654 LQYGCPDECV 663
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 969 bits (2504), Expect = 0.0
Identities = 490/550 (89%), Positives = 503/550 (91%), Gaps = 25/550 (4%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEI HHIT+RDADR+L+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 162 MTIISVTLEIPHHITQRDADRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPST 221
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQED FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 222 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 281
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDL+TSTIKVP
Sbjct: 282 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVP 341
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLATSAC PISSSKSNGLSKDM D GLGDSICFSPSISSTTSPKLN P
Sbjct: 342 GKWPSLATSACTPISSSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 392
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 393 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 436
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 437 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 496
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIHRSLG LSRVRSLELDDWPVELRKVMSSI NDLANSIWEGSSQGQTKPS
Sbjct: 497 LMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQTKPSE 556
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
+STREEKERWIRSKYE KLFLAPLPCTELSLGQ LLRATADEDL+TAILLLAHGS EEVN
Sbjct: 557 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSCEEVN 616
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 617 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 676
Query: 541 LQYGCPDECV 550
LQYGCPDECV
Sbjct: 677 LQYGCPDECV 686
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 961 bits (2483), Expect = 0.0
Identities = 489/550 (88%), Positives = 501/550 (91%), Gaps = 27/550 (4%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 162 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPT 221
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQED FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 222 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 281
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP
Sbjct: 282 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 341
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLATSACAPISSSKSNGLSKDM D GLGDSICFSP ISSTTSPKLN P
Sbjct: 342 GKWPSLATSACAPISSSKSNGLSKDM---------DTGLGDSICFSPGISSTTSPKLNPP 392
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 393 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 436
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 437 AIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 496
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIHRS GTRLSRVRSLELDDWPVELRKVMSSIGN+LANSIWEGSSQGQTKPSI
Sbjct: 497 LMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQGQTKPSI 556
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
+STREEKE WIRSKYE KLFLAPLPCTELSLGQ LLRAT DEDL+TAILLLAHGSREEVN
Sbjct: 557 KSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLLAHGSREEVN 616
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVL QLL GVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 617 ETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINVL 674
Query: 541 LQYGCPDECV 550
LQYGCPDECV
Sbjct: 675 LQYGCPDECV 684
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 959 bits (2480), Expect = 0.0
Identities = 489/550 (88%), Positives = 500/550 (90%), Gaps = 27/550 (4%)
Query: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 162 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPT 221
Query: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
PSTSQED FSVPPTANTPTP+CK SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 222 PSTSQEDPQFSVPPTANTPTPVCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 281
Query: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP
Sbjct: 282 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 341
Query: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
GKWPSLATSACAPISSSKSNGLSKDM D GLGDSICFSP ISSTTSPKLN P
Sbjct: 342 GKWPSLATSACAPISSSKSNGLSKDM---------DTGLGDSICFSPGISSTTSPKLNPP 392
Query: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 393 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 436
Query: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
AIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 437 AIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 496
Query: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
LMCIECSGIHRS GTRLSRVRSLELDDWPVELRKVMSSIGN+LANSIWEGSSQGQTKPSI
Sbjct: 497 LMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELANSIWEGSSQGQTKPSI 556
Query: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
+STREEKE WIRSKYE KLFLAPLPCTELSLGQ LLRAT DEDL+TAILLLAHGSREEVN
Sbjct: 557 KSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDLQTAILLLAHGSREEVN 616
Query: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
ETCGEGDGCTALHLACRKGNVVL QLL GVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 617 ETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINVL 674
Query: 541 LQYGCPDECV 550
LQYGCPDECV
Sbjct: 675 LQYGCPDECV 684
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 853 bits (2204), Expect = 0.0
Identities = 425/516 (82%), Positives = 467/516 (90%), Gaps = 3/516 (0%)
Query: 36 STVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTS 95
S VHI++ NGGGSL++YSSS+P TPSTSQ++L VPPTANTPTP+ KQS SNLFTS
Sbjct: 261 SAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTS 320
Query: 96 EKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCSNGVLTY 154
KGSDPDK +K LES AD+IGSGRAIPIKQGMLLKRSGK L K WKKKYVTLC NGVLTY
Sbjct: 321 RKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTY 380
Query: 155 YSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEALHMSAN 214
+ SL DYM+N+H KEIDL +T+KVPGK P ATSACAPISS K+NGLSKDM +LH+S N
Sbjct: 381 HPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPN 440
Query: 215 SDIGLGDSICFSPSISSTTSPKLNLPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEE- 273
SD GLGDS+C SPSISSTTSPKL+ PPSPHAN+KKH +KKST+N K DGLS TAEE+EE
Sbjct: 441 SDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEEN 500
Query: 274 -KFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQ 332
+F+IVS+TGQT HF+ATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQSEAMALQ
Sbjct: 501 FEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQ 560
Query: 333 SIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVEL 392
SI+NMRGNSHCVDCETQNP WASLNLG LMCIECSGIHR+LGT LSRVRSL+LDDWPVEL
Sbjct: 561 SIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVEL 620
Query: 393 RKVMSSIGNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLG 452
KVMSSIGN+LANS+WE SSQG+TKPS++STREEKERWIR+KYE KLFLAPLPCTELSLG
Sbjct: 621 IKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLG 680
Query: 453 QHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGV 512
QHLLRATADEDLRTAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGV
Sbjct: 681 QHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGV 740
Query: 513 DVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 548
DV ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 741 DVTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 776
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 828 bits (2140), Expect = 0.0
Identities = 425/569 (74%), Positives = 467/569 (82%), Gaps = 56/569 (9%)
Query: 36 STVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTS 95
S VHI++ NGGGSL++YSSS+P TPSTSQ++L VPPTANTPTP+ KQS SNLFTS
Sbjct: 261 SAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTS 320
Query: 96 EKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCSNGVLTY 154
KGSDPDK +K LES AD+IGSGRAIPIKQGMLLKRSGK L K WKKKYVTLC NGVLTY
Sbjct: 321 RKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTY 380
Query: 155 YSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEALHMSAN 214
+ SL DYM+N+H KEIDL +T+KVPGK P ATSACAPISS K+NGLSKDM +LH+S N
Sbjct: 381 HPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPN 440
Query: 215 S-----------------------------------------------------DIGLGD 221
S D GLGD
Sbjct: 441 SGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGD 500
Query: 222 SICFSPSISSTTSPKLNLPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEE--KFMIVS 279
S+C SPSISSTTSPKL+ PPSPHAN+KKH +KKST+N K DGLS TAEE+EE +F+IVS
Sbjct: 501 SVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVS 560
Query: 280 VTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRG 339
+TGQT HF+ATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQSEAMALQSI+NMRG
Sbjct: 561 LTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRG 620
Query: 340 NSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSI 399
NSHCVDCETQNP WASLNLG LMCIECSGIHR+LGT LSRVRSL+LDDWPVEL KVMSSI
Sbjct: 621 NSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSI 680
Query: 400 GNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRAT 459
GN+LANS+WE SSQG+TKPS++STREEKERWIR+KYE KLFLAPLPCTELSLGQHLLRAT
Sbjct: 681 GNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRAT 740
Query: 460 ADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDA 519
ADEDLRTAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVDV ARDA
Sbjct: 741 ADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDA 800
Query: 520 HGNTALTYARQASSQECINVLLQYGCPDE 548
HGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 801 HGNTALAYARQASSQECIDVLLQYGCPDE 829
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 592 bits (1526), Expect = e-169
Identities = 313/564 (55%), Positives = 394/564 (69%), Gaps = 53/564 (9%)
Query: 38 VHITKKRNGGGS-LNNYSSSIPLTPSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSE 96
VHI + NGGGS ++YSSS+P TPS SQ +L ++TPTPI KQS SN+FTS
Sbjct: 319 VHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSR 378
Query: 97 KGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCSNGVLTYY 155
KG+D D+ +KA E D+IGSGRAIPIKQG+LLKRSGK L K WKKKYVTLC NG+LTY+
Sbjct: 379 KGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYH 438
Query: 156 SSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDME-------- 207
SL DYM+NIH KEIDL +T+KVPGK AT A AP +S ++NGLS +
Sbjct: 439 PSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGT 498
Query: 208 -----ALHMSANSDIGLGDSICFSP----------SISS--------------------- 231
A S +S+ L S P S+SS
Sbjct: 499 GAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQWSEATTSLPPGMQHPASG 558
Query: 232 -----TTSPKLNLPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEE--KFMIVSVTGQT 284
++SPKL+ PPSPH+N+KKH +KKST + DG SS EE EE +F++VS+TGQT
Sbjct: 559 PAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEEAEESFEFVVVSLTGQT 618
Query: 285 CHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCV 344
HF+A+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+ A+A+Q+++ +RGNS C+
Sbjct: 619 WHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCI 678
Query: 345 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 404
DC+ NP WASLNLG LMCIECSGIHR LG LSRVRSL+LDDWP EL VM+++GN LA
Sbjct: 679 DCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALA 738
Query: 405 NSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDL 464
NS+WEG+ G +KP ++ REEKERWIR+KYE KLFLAPLP +++ LGQ LLRA ++DL
Sbjct: 739 NSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDL 798
Query: 465 RTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 524
R ++LLAHGS+EEVNET G+GDG TALHL+ NVV QLLIWYGVDV +RDA G T
Sbjct: 799 RLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTP 858
Query: 525 LTYARQASSQECINVLLQYGCPDE 548
L YAR+A SQEC ++L+Q+GCP E
Sbjct: 859 LAYARRAGSQECADILIQHGCPGE 882
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 478 bits (1231), Expect = e-135
Identities = 265/550 (48%), Positives = 347/550 (63%), Gaps = 38/550 (6%)
Query: 32 SFAFSTVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTP--ICKQSMGW 89
S + ++ + + + GG ++YSSS+P +P+ +L A TP + + +
Sbjct: 251 SHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRR 310
Query: 90 SNLFTSEKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCS 148
++LF + +GSD +K ++L+S +T GSGRAIPIKQ LLKRSG L K WKKKYVTL S
Sbjct: 311 TSLFANRRGSDSEK--RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSS 368
Query: 149 NGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEA 208
NG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ NGL KDM
Sbjct: 369 NGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASINGLVKDMST 426
Query: 209 LHMSAN------------------------------SDIGLGDSICFSPSISSTTSPKLN 238
+ M D L ++ + S SP L+
Sbjct: 427 VQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSP-LS 485
Query: 239 LPPSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAW 298
P P KK +KK T K +G + AEEE +F+IVS TGQT HF+A ++EERDAW
Sbjct: 486 REPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFEERDAW 545
Query: 299 VQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNL 358
VQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +GNS CVDC NP WASLNL
Sbjct: 546 VQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNL 605
Query: 359 GVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKP 418
G L+CIECSGIHR+LGT LSRVRSL+LDDWP EL V+++IGND AN +WE ++G+ KP
Sbjct: 606 GALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKP 665
Query: 419 SIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREE 478
S +S+REE+E WIR+KYE LFLAPL +E LG+ L A +D+ T +LLLAH
Sbjct: 666 SRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGP 725
Query: 479 VNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN 538
++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA SQ C +
Sbjct: 726 LDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCAD 785
Query: 539 VLLQYGCPDE 548
+LLQ+GCP E
Sbjct: 786 ILLQHGCPGE 795
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 466 bits (1200), Expect = e-131
Identities = 265/570 (46%), Positives = 347/570 (60%), Gaps = 58/570 (10%)
Query: 32 SFAFSTVHITKKRNGGGSLNNYSSSIPLTPSTSQEDLYFSVPPTANTPTP--ICKQSMGW 89
S + ++ + + + GG ++YSSS+P +P+ +L A TP + + +
Sbjct: 587 SHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRR 646
Query: 90 SNLFTSEKGSDPDKGRKALESHADTIGSGRAIPIKQGMLLKRSGKWL-KTWKKKYVTLCS 148
++LF + +GSD +K ++L+S +T GSGRAIPIKQ LLKRSG L K WKKKYVTL S
Sbjct: 647 TSLFANRRGSDSEK--RSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSS 704
Query: 149 NGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMEA 208
NG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ NGL KDM
Sbjct: 705 NGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASINGLVKDMST 762
Query: 209 LHMSAN------------------------------SDIGLGDSICFSPSISSTTSPKLN 238
+ M D L ++ + S SP L+
Sbjct: 763 VQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSP-LS 821
Query: 239 LPPSPHANKKKHLKKKSTNNLKDDGLSSTAE--------------------EEEEKFMIV 278
P P KK +KK T K +G + AE EE +F+IV
Sbjct: 822 REPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIV 881
Query: 279 SVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMR 338
S TGQT HF+A ++EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +
Sbjct: 882 SSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAK 941
Query: 339 GNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSS 398
GNS CVDC NP WASLNLG L+CIECSGIHR+LGT LSRVRSL+LDDWP EL V+++
Sbjct: 942 GNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTA 1001
Query: 399 IGNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRA 458
IGND AN +WE ++G+ KPS +S+REE+E WIR+KYE LFLAPL +E LG+ L A
Sbjct: 1002 IGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAA 1061
Query: 459 TADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARD 518
+D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG DV ARD
Sbjct: 1062 VQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARD 1121
Query: 519 AHGNTALTYARQASSQECINVLLQYGCPDE 548
A G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 1122 AQGRTALFYARQAGSQLCADILLQHGCPGE 1151
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 342 bits (876), Expect = 7e-94
Identities = 167/173 (96%), Positives = 170/173 (98%)
Query: 378 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSIESTREEKERWIRSKYEH 437
SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS +STREEKERWIRSKYE
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 171
Query: 438 KLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACR 497
KLFLAPLPCT+LSLGQ LLRATADEDL+TAILLLAHGSREEVNETCGEGDGCTALHLACR
Sbjct: 172 KLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 231
Query: 498 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 550
KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV
Sbjct: 232 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 284
Score = 33.1 bits (74), Expect = 0.68
Identities = 15/19 (78%), Positives = 18/19 (94%)
Query: 16 ERDADRSLTILDEQLYSFA 34
+RDADRSL+I DEQL+SFA
Sbjct: 93 DRDADRSLSIPDEQLHSFA 111
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 148 bits (374), Expect = 1e-35
Identities = 91/223 (40%), Positives = 127/223 (56%), Gaps = 26/223 (11%)
Query: 248 KKHLKKKSTNNLKDDGLSST--AEEEEEKFM--IVSVTGQTCHFKATTYEERDAWVQAIQ 303
+K LK T + D L S E+ E +F ++S T ++C +A + + R AWVQA+Q
Sbjct: 301 QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPT-KSCMLQADSEKLRQAWVQAVQ 359
Query: 304 SQILASLQ----SCES-------SKSKSQLTSQSEAM--------ALQSIQNMRGNSHCV 344
+ I ++ + SC S S S S + S ++ LQ +Q++ GNS C
Sbjct: 360 ASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCG 419
Query: 345 DCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 404
DC +P+WAS+NLGVL+CIECSGIHRSLG S+VRSL LD W EL K+M +GN
Sbjct: 420 DCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAV 479
Query: 405 NSIWEGSSQ--GQTKPSIESTREEKERWIRSKYEHKLFLAPLP 445
N I+E + G KP+ S+R++KE WI+ KY K FL P
Sbjct: 480 NQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAP 522
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 448 ELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLL 507
EL G RA DL LAHG+ EVN E +G T L A G++++ + L
Sbjct: 665 ELHPGLLAHRAARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFL 722
Query: 508 IWYGVDVMARDAHGNTALTYA 528
+ G DV RD+ G L +A
Sbjct: 723 LQNGADVNQRDSRGRAPLHHA 743
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 132 bits (332), Expect = 8e-31
Identities = 75/186 (40%), Positives = 110/186 (59%), Gaps = 21/186 (11%)
Query: 275 FMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 325
F +VS T ++C +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
Query: 326 SEAM--------ALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRL 377
+E+ ALQ +Q + GN+ C DC +P+WAS+NLG+ +CIECSGIHRSLG
Sbjct: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
Query: 378 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSIESTREEKERWIRSKY 435
S+VRSL LD W EL K+M +GND+ N ++E + G KP R+EKE +IR+KY
Sbjct: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKY 507
Query: 436 EHKLFL 441
+ F+
Sbjct: 508 VERKFV 513
Score = 36.2 bits (82), Expect = 0.080
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 444 LPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 503
L L+ G L RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
Query: 504 AQLLIWYGVDVMARDAHGNTALTYA 528
+ L+ G +V RD G L +A
Sbjct: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 130 bits (326), Expect = 4e-30
Identities = 100/322 (31%), Positives = 137/322 (42%), Gaps = 71/322 (22%)
Query: 275 FMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSK-------------SQ 321
F +VS T ++C +A + WV A+QS I ++ S S
Sbjct: 329 FEVVS-TSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSA 387
Query: 322 LTSQSEAMA-----------LQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIH 370
T S MA + +Q++ GN+ C DC P+WAS+NLGV +CI+CSGIH
Sbjct: 388 ATLGSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIH 447
Query: 371 RSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT--KPSIESTREEKE 428
RSLG S+VRSL LD W EL K+M +GN + N I+E + KP +R+EKE
Sbjct: 448 RSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKE 507
Query: 429 RWIRSKYEHKLFLAPLP-----------------------------------------CT 447
WI +KY K FL LP
Sbjct: 508 AWIHAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLG 567
Query: 448 ELSLGQHLLRATA-DEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 506
L G L RA+ L T LAHG+ +VN G D T L A +++ +
Sbjct: 568 SLHPGALLFRASGHPPSLPTMADALAHGA--DVNWVNGGQDNATPLIQATAANSLLACEF 625
Query: 507 LIWYGVDVMARDAHGNTALTYA 528
L+ G +V D+ G L +A
Sbjct: 626 LLQNGANVNQADSAGRGPLHHA 647
Score = 41.2 bits (95), Expect = 0.002
Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 4/86 (4%)
Query: 455 LLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDV 514
L++ATA L LL +G+ ++ G G LH A G+ LA L + G D+
Sbjct: 611 LIQATAANSLLACEFLLQNGANVNQADSAGRGP----LHHATILGHTGLACLFLKRGADL 666
Query: 515 MARDAHGNTALTYARQASSQECINVL 540
ARD+ G LT A + ++ + + +L
Sbjct: 667 GARDSEGRDPLTIAMETANADIVTLL 692
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 127 bits (319), Expect = 3e-29
Identities = 89/282 (31%), Positives = 142/282 (50%), Gaps = 12/282 (4%)
Query: 270 EEEEKFMIVSVTGQTCHFKATTYEERDAWVQAI---QSQILASLQSCESSKSKSQLTSQS 326
E+++ F ++S +T HF+A ++ AW+ + + + L E S ++ L +
Sbjct: 380 EDKKSFDLIS-HNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLT 438
Query: 327 EAMALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELD 386
+A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIHR +G +SR++SLELD
Sbjct: 439 KAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELD 497
Query: 387 DWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSIESTREEKERWIRSKYEHKLFLAPLP 445
+ ++GN+ N I E + + KP+ S ++ +I +KY F
Sbjct: 498 KLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
Query: 446 CTELSLGQHLLRATADEDLRTAILLLAHGSR--EEVNETCGEGDGCTALHLACR---KGN 500
T + LL A DL I + A G E + E G+ G TALHLA R + +
Sbjct: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETALHLAVRTADQTS 616
Query: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
+ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 617 LHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 120 bits (302), Expect = 2e-27
Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 120 bits (302), Expect = 2e-27
Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 120 bits (302), Expect = 2e-27
Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 120 bits (302), Expect = 2e-27
Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 120 bits (302), Expect = 2e-27
Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 120 bits (302), Expect = 2e-27
Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
Query: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
Query: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 119 bits (299), Expect = 5e-27
Identities = 93/292 (31%), Positives = 138/292 (47%), Gaps = 26/292 (8%)
Query: 271 EEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-- 328
EE+K + +T HF+A E +AWV +Q+ +L S + + S A
Sbjct: 349 EEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGH 408
Query: 329 ---------MALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSR 379
+ + +++ GNS C DC +P W S NLGVL CI+CSG+HR LG R SR
Sbjct: 409 DGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSR 468
Query: 380 VRSLELD-DWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSIESTREEKERWIRSKY- 435
++SL LD P EL + ++GN N + E S G KPS ES + +I +KY
Sbjct: 469 MQSLTLDLLGPSELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYV 527
Query: 436 EHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGS--REEVNETCGEGDGCTALH 493
EH+ P Q L A + DL + + A+G + + + LH
Sbjct: 528 EHRFARRCTP-----EPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLH 582
Query: 494 LACRKGN---VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
LA + N + L +I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 583 LAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 119 bits (299), Expect = 5e-27
Identities = 93/292 (31%), Positives = 138/292 (47%), Gaps = 26/292 (8%)
Query: 271 EEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-- 328
EE+K + +T HF+A E +AWV +Q+ +L S + + S A
Sbjct: 358 EEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGH 417
Query: 329 ---------MALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSR 379
+ + +++ GNS C DC +P W S NLGVL CI+CSG+HR LG R SR
Sbjct: 418 DGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSR 477
Query: 380 VRSLELD-DWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSIESTREEKERWIRSKY- 435
++SL LD P EL + ++GN N + E S G KPS ES + +I +KY
Sbjct: 478 MQSLTLDLLGPSELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYV 536
Query: 436 EHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGS--REEVNETCGEGDGCTALH 493
EH+ P Q L A + DL + + A+G + + + LH
Sbjct: 537 EHRFARRCTP-----EPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLH 591
Query: 494 LACRKGN---VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
LA + N + L +I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 592 LAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 643
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 118 bits (296), Expect = 1e-26
Identities = 72/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 343 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 402
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 403 LANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC------TE 448
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 449 LSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 508
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
Query: 509 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
YG D + D +G T + YARQA E L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 118 bits (296), Expect = 1e-26
Identities = 72/214 (33%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 343 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGND 402
C DC +P WAS++ GVL+C EC +HRSLG +S V+ L WP L +++ ++ ++
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 403 LANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC------TE 448
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 449 LSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 508
L + L + +L T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
Query: 509 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
YG D + D +G T + YARQA E L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 112 bits (279), Expect = 1e-24
Identities = 80/286 (27%), Positives = 133/286 (46%), Gaps = 11/286 (3%)
Query: 267 TAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLT 323
T EE++ F ++S +T HF+A +E W+ +Q+ +L + + + ++ +
Sbjct: 358 TNPEEKKCFDLIS-HDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIV 416
Query: 324 SQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSL 383
+ + +Q M GN C DC +P W S NLG+L CIECSGIHR LG SR++SL
Sbjct: 417 QELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSL 476
Query: 384 ELDDWPVELRKVMSSIGNDLANSIWEG--SSQGQTKPSIESTREEKERWIRSKYEHKLFL 441
LD + +IGN N I E ++ KP+ S ++ +I +KY + +
Sbjct: 477 TLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYA 536
Query: 442 APLPCTELSLGQHLLRATADEDLRTAILLLAHG--SREEVNETCGEGDGCTALHLACR-- 497
+ L A D+ + A G E++ G TALHLA R
Sbjct: 537 RKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSV 596
Query: 498 -KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
+ ++ + L+ ++ + G+TAL Y + EC+ +LL+
Sbjct: 597 DRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 112 bits (279), Expect = 1e-24
Identities = 80/286 (27%), Positives = 133/286 (46%), Gaps = 11/286 (3%)
Query: 267 TAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLT 323
T EE++ F ++S +T HF+A +E W+ +Q+ +L + + + ++ +
Sbjct: 358 TNPEEKKCFDLIS-HDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIV 416
Query: 324 SQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSL 383
+ + +Q M GN C DC +P W S NLG+L CIECSGIHR LG SR++SL
Sbjct: 417 QELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSL 476
Query: 384 ELDDWPVELRKVMSSIGNDLANSIWEG--SSQGQTKPSIESTREEKERWIRSKYEHKLFL 441
LD + +IGN N I E ++ KP+ S ++ +I +KY + +
Sbjct: 477 TLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYA 536
Query: 442 APLPCTELSLGQHLLRATADEDLRTAILLLAHG--SREEVNETCGEGDGCTALHLACR-- 497
+ L A D+ + A G E++ G TALHLA R
Sbjct: 537 RKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSV 596
Query: 498 -KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
+ ++ + L+ ++ + G+TAL Y + EC+ +LL+
Sbjct: 597 DRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,217,997
Number of Sequences: 37866
Number of extensions: 959255
Number of successful extensions: 4270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 325
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 2814
Number of HSP's gapped (non-prelim): 1358
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.