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Search of human proteins with 148806859
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148806859 calcium/calmodulin-dependent protein kinase 1
alpha isoform b [Homo sapiens]
(520 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha... 1046 0.0
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ... 953 0.0
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ... 953 0.0
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2... 566 e-161
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2... 566 e-161
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2... 566 e-161
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2... 566 e-161
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2... 480 e-135
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2... 480 e-135
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2... 480 e-135
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 132 6e-31
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] 130 3e-30
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 127 2e-29
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 125 7e-29
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 125 1e-28
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 125 1e-28
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 125 1e-28
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 124 3e-28
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 124 3e-28
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 124 3e-28
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 124 3e-28
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 124 3e-28
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 124 3e-28
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 123 4e-28
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 123 4e-28
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 123 4e-28
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 122 8e-28
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 122 8e-28
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 122 8e-28
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 122 8e-28
>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
isoform b [Homo sapiens]
Length = 520
Score = 1046 bits (2705), Expect = 0.0
Identities = 520/520 (100%), Positives = 520/520 (100%)
Query: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
Query: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLD 240
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLD
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLD 240
Query: 241 STNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 300
STNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG
Sbjct: 241 STNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 300
Query: 301 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 360
LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI
Sbjct: 301 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 360
Query: 361 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 420
SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL
Sbjct: 361 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 420
Query: 421 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 480
KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP
Sbjct: 421 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 480
Query: 481 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 520
SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV
Sbjct: 481 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 520
>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 953 bits (2464), Expect = 0.0
Identities = 482/520 (92%), Positives = 482/520 (92%), Gaps = 38/520 (7%)
Query: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
Query: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLD 240
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL------------ 228
Query: 241 STNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 300
VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG
Sbjct: 229 --------------------------VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 262
Query: 301 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 360
LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI
Sbjct: 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 322
Query: 361 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 420
SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL
Sbjct: 323 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 382
Query: 421 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 480
KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP
Sbjct: 383 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 442
Query: 481 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 520
SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV
Sbjct: 443 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 482
>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 953 bits (2464), Expect = 0.0
Identities = 482/520 (92%), Positives = 482/520 (92%), Gaps = 38/520 (7%)
Query: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
Sbjct: 1 MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR 60
Query: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
Sbjct: 61 LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE 120
Query: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
Sbjct: 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ 180
Query: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLD 240
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL
Sbjct: 181 AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYL------------ 228
Query: 241 STNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 300
VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG
Sbjct: 229 --------------------------VFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILG 262
Query: 301 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 360
LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI
Sbjct: 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 322
Query: 361 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 420
SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL
Sbjct: 323 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEEL 382
Query: 421 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 480
KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP
Sbjct: 383 KDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIP 442
Query: 481 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 520
SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV
Sbjct: 443 SWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV 482
>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 567 bits (1460), Expect = e-161
Identities = 288/467 (61%), Positives = 360/467 (77%), Gaps = 50/467 (10%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
Query: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
Query: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Query: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
Query: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
+P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++G EPLPSE+E+C++VEVTEEEV
Sbjct: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEV 471
Query: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 472 ENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 517
>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 1 [Homo sapiens]
Length = 588
Score = 567 bits (1460), Expect = e-161
Identities = 288/467 (61%), Positives = 360/467 (77%), Gaps = 50/467 (10%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
Query: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
Query: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Query: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
Query: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
+P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++G EPLPSE+E+C++VEVTEEEV
Sbjct: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEV 471
Query: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 472 ENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 517
>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 567 bits (1460), Expect = e-161
Identities = 288/467 (61%), Positives = 360/467 (77%), Gaps = 50/467 (10%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
Query: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
Query: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Query: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
Query: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
+P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++G EPLPSE+E+C++VEVTEEEV
Sbjct: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEV 471
Query: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 472 ENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 517
>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 5 [Homo sapiens]
Length = 533
Score = 567 bits (1460), Expect = e-161
Identities = 288/467 (61%), Positives = 360/467 (77%), Gaps = 50/467 (10%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
Query: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
Query: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Query: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
Query: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
+P+I+E+LKDLI +MLDKNPE+RI VP+IKLHPWVT++G EPLPSE+E+C++VEVTEEEV
Sbjct: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEV 471
Query: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
+NSV+ IPS TVILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 472 ENSVKHIPSLATVILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 517
>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 4 [Homo sapiens]
Length = 498
Score = 480 bits (1235), Expect = e-135
Identities = 257/467 (55%), Positives = 321/467 (68%), Gaps = 93/467 (19%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
Query: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
Query: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Query: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
Query: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
+P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIK------------------------------ 441
Query: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
ILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 442 -------------ILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 474
>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 3 [Homo sapiens]
Length = 545
Score = 480 bits (1235), Expect = e-135
Identities = 257/467 (55%), Positives = 321/467 (68%), Gaps = 93/467 (19%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
Query: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
Query: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Query: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
Query: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
+P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIK------------------------------ 441
Query: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
ILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 442 -------------ILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 474
>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 6 [Homo sapiens]
Length = 490
Score = 480 bits (1235), Expect = e-135
Identities = 257/467 (55%), Positives = 321/467 (68%), Gaps = 93/467 (19%)
Query: 64 ARPSLSARKLSLQERP-----AGSYLEAQAG------PYATGPASHISPRAWRRPTIESH 112
ARP LS RKLSLQER AG L+ PY+ + SPR RRPT+ESH
Sbjct: 90 ARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149
Query: 113 HVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPR 172
HV+I+ +DCVQLNQY L+ EIGKG+YGVV+LAYNE+++ +YAMKVLSKKKL++Q GFPR
Sbjct: 150 HVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 209
Query: 173 RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQN 232
RPPPRG++ A GG + P+E+VYQEIAILKKLDH NVVKL+EVLDDP ED+LY+
Sbjct: 210 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYM---- 265
Query: 233 QAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARL 292
VF+L+ +GPVMEVP KP SE+QAR
Sbjct: 266 ----------------------------------VFELVNQGPVMEVPTLKPLSEDQARF 291
Query: 293 YLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP 352
Y +D+I G+EYLH QKI+HRDIKPSNLL+G+DGH+KIADFGVSN+F+G+DA LS+T GTP
Sbjct: 292 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP 351
Query: 353 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPE 412
AFMAPE++S++ + FSGKALDVWA GVTLYCFV+G+CPF+D+ I+ LH KIK++ + FP+
Sbjct: 352 AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD 411
Query: 413 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEV 472
+P+I+E+LKDLI +MLDKNPE+RI VP+IK
Sbjct: 412 QPDIAEDLKDLITRMLDKNPESRIVVPEIK------------------------------ 441
Query: 473 KNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLL 519
ILVK+M+RKRSFGNPFE +RREERS+SAPGNLL
Sbjct: 442 -------------ILVKTMIRKRSFGNPFE-GSRREERSLSAPGNLL 474
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 132 bits (333), Expect = 6e-31
Identities = 92/333 (27%), Positives = 162/333 (48%), Gaps = 70/333 (21%)
Query: 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPA 187
Y+L+ +GKG G+V+L + + A+K+++++KL +
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESV------------------- 74
Query: 188 KQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIAKP 247
L +V +EIAILK ++H +V+KL +V ++ + LYL L++ +
Sbjct: 75 -----LMKVEREIAILKLIEHPHVLKLHDVYEN--KKYLYLVLEHVSGG----------- 116
Query: 248 HSLLPSEQQDSGSTWAARSVFD-LLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHC 306
+FD L++KG + + ++AR + R ++ L++ H
Sbjct: 117 ------------------ELFDYLVKKGRL---------TPKEARKFFRQIVSALDFCHS 149
Query: 307 QKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQS 366
I HRD+KP NLLL + +++IADFG+++ + D+ L ++ G+P + PE I G+
Sbjct: 150 YSICHRDLKPENLLLDEKNNIRIADFGMAS-LQVGDSLLETSCGSPHYACPEVI--KGEK 206
Query: 367 FSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKDLILK 426
+ G+ D+W+ GV L+ + G PF DD + L K+K VF I + + L+
Sbjct: 207 YDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRG--VFHMPHFIPPDCQSLLRG 264
Query: 427 MLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEE 459
M++ PE R+ + I+ HPW EP P E
Sbjct: 265 MIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLE 297
>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
Length = 433
Score = 130 bits (327), Expect = 3e-30
Identities = 104/337 (30%), Positives = 150/337 (44%), Gaps = 66/337 (19%)
Query: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 184
+ +Y + +G+G+YG V+ + A+K+L KKKL R P G
Sbjct: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL--------RRIPNGEA---- 93
Query: 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNI 244
V +EI +L++L H NV++L++VL + + +Y+ ++ +Q
Sbjct: 94 ----------NVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQ------ 137
Query: 245 AKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYL 304
E DS VP +K F QA Y +I GLEYL
Sbjct: 138 ---------EMLDS--------------------VP-EKRFPVCQAHGYFCQLIDGLEYL 167
Query: 305 HCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE--GNDAQLSSTAGTPAFMAPEAISD 362
H Q IVH+DIKP NLLL G +KI+D GV+ D ++ G+PAF PE I++
Sbjct: 168 HSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPE-IAN 226
Query: 363 SGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKD 422
+FSG +D+W+ GVTLY G PF D I L I P + L D
Sbjct: 227 GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIP--GDCGPPLSD 284
Query: 423 LILKMLDKNPETRIGVPDIKLHPWVTKN---GEEPLP 456
L+ ML+ P R + I+ H W K E P+P
Sbjct: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVP 321
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 127 bits (320), Expect = 2e-29
Identities = 90/325 (27%), Positives = 152/325 (46%), Gaps = 68/325 (20%)
Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
V++ Y ++ +GKG + VV+L + A+K++ K +L
Sbjct: 15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL------------------ 56
Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDST 242
+ LE++Y+E+ I+K LDH +++KL +V++ + LYL
Sbjct: 57 ------DAVNLEKIYREVQIMKMLDHPHIIKLYQVME--TKSMLYLV------------- 95
Query: 243 NIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLE 302
+E +G +FD L + +E +AR ++ ++
Sbjct: 96 ----------TEYAKNGE------IFDYLANHGRL--------NESEARRKFWQILSAVD 131
Query: 303 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISD 362
Y H +KIVHRD+K NLLL ++ ++KIADFG N F+ + L++ G+P + APE
Sbjct: 132 YCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGEL-LATWCGSPPYAAPEVF-- 188
Query: 363 SGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKD 422
GQ + G LD+W+ GV LY V G PF + L +++ P +SE+ +
Sbjct: 189 EGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPY--FMSEDCEH 246
Query: 423 LILKMLDKNPETRIGVPDIKLHPWV 447
LI +ML +P R+ + IK H W+
Sbjct: 247 LIRRMLVLDPSKRLTIAQIKEHKWM 271
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 125 bits (315), Expect = 7e-29
Identities = 91/351 (25%), Positives = 167/351 (47%), Gaps = 52/351 (14%)
Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
V++ Y L +G G +G V++ +E A+K+L+++K+
Sbjct: 22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKI------------------ 63
Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDST 242
+ L + ++ +EI LK H +++KL +V+ P++ + + + +
Sbjct: 64 -----RSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICK 118
Query: 243 NIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLE 302
N K S +P + +GST K E+++R + ++ G++
Sbjct: 119 NGRK--SDVPGVVK-TGST---------------------KELDEKESRRLFQQILSGVD 154
Query: 303 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISD 362
Y H +VHRD+KP N+LL + KIADFG+SN + L ++ G+P + APE I
Sbjct: 155 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSPNYAAPEVI-- 211
Query: 363 SGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKD 422
SG+ ++G +D+W++GV LY + G PF DD + L +KI + +F ++ +
Sbjct: 212 SGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG--IFYTPQYLNPSVIS 269
Query: 423 LILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVK 473
L+ ML +P R + DI+ H W ++ + L E+ S + +E +K
Sbjct: 270 LLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALK 320
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 125 bits (313), Expect = 1e-28
Identities = 96/335 (28%), Positives = 147/335 (43%), Gaps = 75/335 (22%)
Query: 117 SDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPP 176
S A++ L+Q++ +G G++G V L ++ HYAMK+L K+K++K
Sbjct: 25 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVK---------- 74
Query: 177 RGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQN 236
L +E E IL+ ++ +VKL D NLY+ ++
Sbjct: 75 -------------LKQIEHTLNEKRILQAVNFPFLVKLEFSFKD--NSNLYMVME----- 114
Query: 237 IQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRD 296
+P + S R FSE AR Y
Sbjct: 115 -------------YVPGGEMFSHLRRIGR-------------------FSEPHARFYAAQ 142
Query: 297 VILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMA 356
++L EYLH +++RD+KP NLL+ G++++ DFG + + +G L GTP ++A
Sbjct: 143 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLA 199
Query: 357 PEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEI 416
PE I G + KA+D WA GV +Y G PF D + ++ KI + V FP
Sbjct: 200 PEIILSKGYN---KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS--HF 254
Query: 417 SEELKDLILKMLDKNPETRI-----GVPDIKLHPW 446
S +LKDL+ +L + R GV DIK H W
Sbjct: 255 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 289
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 125 bits (313), Expect = 1e-28
Identities = 96/335 (28%), Positives = 147/335 (43%), Gaps = 75/335 (22%)
Query: 117 SDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPP 176
S A++ L+Q++ +G G++G V L ++ HYAMK+L K+K++K
Sbjct: 33 SPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVK---------- 82
Query: 177 RGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQN 236
L +E E IL+ ++ +VKL D NLY+ ++
Sbjct: 83 -------------LKQIEHTLNEKRILQAVNFPFLVKLEFSFKD--NSNLYMVME----- 122
Query: 237 IQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRD 296
+P + S R FSE AR Y
Sbjct: 123 -------------YVPGGEMFSHLRRIGR-------------------FSEPHARFYAAQ 150
Query: 297 VILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMA 356
++L EYLH +++RD+KP NLL+ G++++ DFG + + +G L GTP ++A
Sbjct: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL---CGTPEYLA 207
Query: 357 PEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEI 416
PE I G + KA+D WA GV +Y G PF D + ++ KI + V FP
Sbjct: 208 PEIILSKGYN---KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPS--HF 262
Query: 417 SEELKDLILKMLDKNPETRI-----GVPDIKLHPW 446
S +LKDL+ +L + R GV DIK H W
Sbjct: 263 SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 297
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 125 bits (313), Expect = 1e-28
Identities = 111/394 (28%), Positives = 170/394 (43%), Gaps = 87/394 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A + ++ + ++
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 305 HCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G AGTP +++PE +
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVF--PEEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK F PE ++ E
Sbjct: 188 KDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPL---PSEEEHCSVVEVTEEEVKNSV 476
K+LI +ML NP RI HPWV + E C ++K ++
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAI 304
Query: 477 RLIPSWTTVIL------VKSMLRKRSFGNPFEPQ 504
TT+++ KS+L K+S G EPQ
Sbjct: 305 -----LTTMLVSRNFSAAKSLLNKKSDGGVKEPQ 333
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 124 bits (310), Expect = 3e-28
Identities = 98/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A ++ ++ + +
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 305 HCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G+ AGTP +++PE +
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 KDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
KDLI KML NP RI + HPW+
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 124 bits (310), Expect = 3e-28
Identities = 98/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A ++ ++ + +
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 305 HCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G+ AGTP +++PE +
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 KDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
KDLI KML NP RI + HPW+
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 124 bits (310), Expect = 3e-28
Identities = 98/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A ++ ++ + +
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 305 HCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G+ AGTP +++PE +
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 KDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
KDLI KML NP RI + HPW+
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 124 bits (310), Expect = 3e-28
Identities = 98/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A ++ ++ + +
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 305 HCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G+ AGTP +++PE +
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 KDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
KDLI KML NP RI + HPW+
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 124 bits (310), Expect = 3e-28
Identities = 98/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A ++ ++ + +
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 305 HCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G+ AGTP +++PE +
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 KDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
KDLI KML NP RI + HPW+
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 124 bits (310), Expect = 3e-28
Identities = 98/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
++Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A ++ ++ + +
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127
Query: 305 HCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G+ AGTP +++PE +
Sbjct: 128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 KDPY---GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
KDLI KML NP RI + HPW+
Sbjct: 245 AKDLINKMLTINPAKRITASEALKHPWI 272
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 123 bits (309), Expect = 4e-28
Identities = 97/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 186
+Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL---------------------S 50
Query: 187 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIAK 246
A+ LER E I + L H N+V+L + + + E + YL
Sbjct: 51 ARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGHHYL------------------ 87
Query: 247 PHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYLH 305
+FDL+ G + E + + +SE A ++ ++ + + H
Sbjct: 88 --------------------IFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127
Query: 306 CQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISD 362
+VHRD+KP NLLL VK+ADFG++ + EG AGTP +++PE +
Sbjct: 128 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187
Query: 363 SGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEEL 420
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 DPY---GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 244
Query: 421 KDLILKMLDKNPETRIGVPDIKLHPWVT 448
KDLI KML NP RI + HPW++
Sbjct: 245 KDLINKMLTINPSKRITAAEALKHPWIS 272
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 123 bits (309), Expect = 4e-28
Identities = 97/328 (29%), Positives = 147/328 (44%), Gaps = 73/328 (22%)
Query: 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGP 186
+Y+L E+GKGA+ VVR + YA K+++ KKL
Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL---------------------S 50
Query: 187 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIAK 246
A+ LER E I + L H N+V+L + + + E + YL
Sbjct: 51 ARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGHHYL------------------ 87
Query: 247 PHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYLH 305
+FDL+ G + E + + +SE A ++ ++ + + H
Sbjct: 88 --------------------IFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127
Query: 306 CQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISD 362
+VHRD+KP NLLL VK+ADFG++ + EG AGTP +++PE +
Sbjct: 128 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187
Query: 363 SGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP--EEPEISEEL 420
GK +D+WA GV LY + G PF D+ L+++IK FP E ++ E
Sbjct: 188 DPY---GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 244
Query: 421 KDLILKMLDKNPETRIGVPDIKLHPWVT 448
KDLI KML NP RI + HPW++
Sbjct: 245 KDLINKMLTINPSKRITAAEALKHPWIS 272
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 123 bits (309), Expect = 4e-28
Identities = 92/368 (25%), Positives = 165/368 (44%), Gaps = 81/368 (22%)
Query: 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 182
V++ Y L +G G +G V++ ++ A+K+L+++K+
Sbjct: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI------------------ 52
Query: 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDST 242
+ L + ++ +EI LK H +++KL +V+ P + + + + +
Sbjct: 53 -----RSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGE------- 100
Query: 243 NIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLE 302
+FD + K +E E +AR + ++ ++
Sbjct: 101 ------------------------LFDYICKHGRVE--------EMEARRLFQQILSAVD 128
Query: 303 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISD 362
Y H +VHRD+KP N+LL + KIADFG+SN + L ++ G+P + APE I
Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSPNYAAPEVI-- 185
Query: 363 SGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEEPEISEELKD 422
SG+ ++G +D+W+ GV LY + G PF D+ + L +KI+ PE ++ +
Sbjct: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE--YLNRSVAT 243
Query: 423 LILKMLDKNPETRIGVPDIKLHPWVTKN------GEEPL--------PSEEEHCSVVEVT 468
L++ ML +P R + DI+ H W ++ E+P + +E C E T
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECT 303
Query: 469 EEEVKNSV 476
E EV NS+
Sbjct: 304 ESEVMNSL 311
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 122 bits (306), Expect = 8e-28
Identities = 97/328 (29%), Positives = 146/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A + ++ + ++
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 305 HCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G AGTP +++PE +
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVF--PEEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK F PE ++ E
Sbjct: 188 KDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
K+LI +ML NP RI HPWV
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 122 bits (306), Expect = 8e-28
Identities = 97/328 (29%), Positives = 146/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A + ++ + ++
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 305 HCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G AGTP +++PE +
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVF--PEEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK F PE ++ E
Sbjct: 188 KDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
K+LI +ML NP RI HPWV
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 122 bits (306), Expect = 8e-28
Identities = 97/328 (29%), Positives = 146/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A + ++ + ++
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 305 HCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G AGTP +++PE +
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVF--PEEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK F PE ++ E
Sbjct: 188 KDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
K+LI +ML NP RI HPWV
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 122 bits (306), Expect = 8e-28
Identities = 97/328 (29%), Positives = 146/328 (44%), Gaps = 73/328 (22%)
Query: 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 185
+ Y+L E+GKGA+ VVR ++ + YA K+++ KKL
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL--------------------- 50
Query: 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIA 245
A+ LER E I + L H N+V+L + + + E YL
Sbjct: 51 SARDHQKLER---EARICRLLKHPNIVRLHDSISE--EGFHYL----------------- 88
Query: 246 KPHSLLPSEQQDSGSTWAARSVFDLLRKGPVME-VPCDKPFSEEQARLYLRDVILGLEYL 304
VFDL+ G + E + + +SE A + ++ + ++
Sbjct: 89 ---------------------VFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 127
Query: 305 HCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 361
H IVHRD+KP NLLL VK+ADFG++ + +G AGTP +++PE +
Sbjct: 128 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 187
Query: 362 DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVF--PEEPEISEE 419
GK +D+WA GV LY + G PF D+ L+++IK F PE ++ E
Sbjct: 188 KDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 244
Query: 420 LKDLILKMLDKNPETRIGVPDIKLHPWV 447
K+LI +ML NP RI HPWV
Sbjct: 245 AKNLINQMLTINPAKRITADQALKHPWV 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,032,657
Number of Sequences: 37866
Number of extensions: 1170948
Number of successful extensions: 6318
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 730
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 4032
Number of HSP's gapped (non-prelim): 1571
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.