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Search of human proteins with 148664197
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148664197 coiled-coil domain containing 40 [Homo sapiens]
(1142 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148664197 coiled-coil domain containing 40 [Homo sapiens] 2201 0.0
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 119 2e-26
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 119 2e-26
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 119 2e-26
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 119 2e-26
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 116 1e-25
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 114 4e-25
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 110 1e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 107 8e-23
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 105 2e-22
gi|156104908 myosin heavy chain 6 [Homo sapiens] 105 3e-22
gi|21735548 centrosomal protein 2 [Homo sapiens] 104 5e-22
gi|42794779 myosin 18A isoform b [Homo sapiens] 102 3e-21
gi|28416946 myosin 18A isoform a [Homo sapiens] 102 3e-21
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 101 4e-21
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 100 6e-21
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 100 6e-21
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 100 6e-21
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 100 8e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 100 8e-21
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 100 8e-21
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 100 1e-20
gi|71061468 centromere protein E [Homo sapiens] 99 2e-20
gi|55770834 centromere protein F [Homo sapiens] 99 3e-20
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 98 5e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 97 9e-20
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 97 9e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 97 9e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 97 9e-20
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 97 9e-20
>gi|148664197 coiled-coil domain containing 40 [Homo sapiens]
Length = 1142
Score = 2201 bits (5703), Expect = 0.0
Identities = 1142/1142 (100%), Positives = 1142/1142 (100%)
Query: 1 MAEPGGAAGRSHPEDGSASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQA 60
MAEPGGAAGRSHPEDGSASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQA
Sbjct: 1 MAEPGGAAGRSHPEDGSASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQA 60
Query: 61 EAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYTETSSPEGQISAADTTYPYFSPP 120
EAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYTETSSPEGQISAADTTYPYFSPP
Sbjct: 61 EAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYTETSSPEGQISAADTTYPYFSPP 120
Query: 121 QELPGEEAYDSVSGEAGLQGFQQEATGPPESRERRVTSPEPSHGVLGPSEQMGQVTSGPA 180
QELPGEEAYDSVSGEAGLQGFQQEATGPPESRERRVTSPEPSHGVLGPSEQMGQVTSGPA
Sbjct: 121 QELPGEEAYDSVSGEAGLQGFQQEATGPPESRERRVTSPEPSHGVLGPSEQMGQVTSGPA 180
Query: 181 VGRLTGSTEEPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGD 240
VGRLTGSTEEPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGD
Sbjct: 181 VGRLTGSTEEPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGD 240
Query: 241 LPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLN 300
LPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLN
Sbjct: 241 LPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLN 300
Query: 301 RQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERR 360
RQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERR
Sbjct: 301 RQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERR 360
Query: 361 QKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQ 420
QKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQ
Sbjct: 361 QKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQ 420
Query: 421 VVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSE 480
VVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSE
Sbjct: 421 VVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSE 480
Query: 481 ACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKS 540
ACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKS
Sbjct: 481 ACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKS 540
Query: 541 IMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD 600
IMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD
Sbjct: 541 IMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD 600
Query: 601 QLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEK 660
QLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEK
Sbjct: 601 QLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEK 660
Query: 661 TNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRT 720
TNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRT
Sbjct: 661 TNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRT 720
Query: 721 ILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRL 780
ILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRL
Sbjct: 721 ILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRL 780
Query: 781 QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDL 840
QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDL
Sbjct: 781 QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDL 840
Query: 841 KKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL 900
KKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL
Sbjct: 841 KKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL 900
Query: 901 VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRA 960
VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRA
Sbjct: 901 VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRA 960
Query: 961 MELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELE 1020
MELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELE
Sbjct: 961 MELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELE 1020
Query: 1021 ETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKE 1080
ETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKE
Sbjct: 1021 ETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKE 1080
Query: 1081 GRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPG 1140
GRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPG
Sbjct: 1081 GRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPG 1140
Query: 1141 PS 1142
PS
Sbjct: 1141 PS 1142
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 119 bits (298), Expect = 2e-26
Identities = 169/790 (21%), Positives = 351/790 (44%), Gaps = 76/790 (9%)
Query: 293 AALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRH 352
AA N Q +L ++ L+ T+Q + Q L + ++ + L++ +H
Sbjct: 824 AAYLKLRNWQWWRLFTKVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH 882
Query: 353 AMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALH-----LFYMQNI 407
+ + E+ +E+LQA LY A A E R +LAA + E+E + LH L ++
Sbjct: 883 SQLTEEKNLLQEQLQAETELY----AEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDR 937
Query: 408 DQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRA--QQLEEDIALFEAQYL 465
Q ++ + + M Q + + E E E +Q L ++++T A ++LE++I + + Q
Sbjct: 938 GQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIM-------QQWASSLVGMKHRDEAHRAVLE 518
+++ ++L + +S+ T + A EK + + + S L ++E R LE
Sbjct: 996 KLSKERKLLEERISDLTTNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 519 AL-RGCQHQAKSTDGEIEAYKKSI----MKEEEKNEKLASILNRTETEATLLQKLTTQCL 573
L R + A +I + I M+ +K E+L + L R + E + QK L
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE--IAQK--NNAL 1110
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIR 633
K L+ + + L A ++ + ++ L EEL+A++ ++ L+ T +R
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELR 1169
Query: 634 EKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQK 693
K ++ +T K K ++ + + M ++ ++ + + LD +++
Sbjct: 1170 AKREQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 694 TLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLE 753
TL + + D+ ++ ++ E+ + +E + + ER +EL ++V L+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-NDKVHKLQ 1286
Query: 754 LEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQE--QEEQLASLDASKKELHIMEQK 811
E++ ++ +++E +GKA++ L ++ + TQE QEE L+ S K L +E++
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEETRQKLNVSTK-LRQLEEE 1344
Query: 812 KLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRS 871
+ ++ ++++E + ++ +E H+ L+ L + + E LE+ + + E + +
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE-IEN 1403
Query: 872 LKASERETIKMQDKL----NQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEM---RSSV 924
L E DKL N+L +E L+ L + EKK + ++ ++
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 925 DSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRK 984
S+ RA + +EK +A+ LA A E + + E
Sbjct: 1464 SSKYADERDRAE--------------AEAREKETKALSLARALEEALEAKEE-------- 1501
Query: 985 ALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADF 1044
L RT+ L+ ++ D+ + D+ K V ELE+++R + + + E + +L ++ +
Sbjct: 1502 -LERTN-----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 1045 DTLEADLTRL 1054
E RL
Sbjct: 1556 QATEDAKLRL 1565
Score = 73.9 bits (180), Expect = 8e-13
Identities = 120/610 (19%), Positives = 242/610 (39%), Gaps = 97/610 (15%)
Query: 292 QAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDR 351
+AA + L + +L+ +L +LVV R L + Q L + + K D
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470
Query: 352 HAMASSERRQKEEE-LQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD 410
A +E R+KE + L ARAL + A E + L+ EME+L
Sbjct: 1471 RDRAEAEAREKETKALSLARAL-EEALEAKEELERTNKMLKAEMEDLV-----------S 1518
Query: 411 MRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAED 470
+DD+ ++K+ K+ + ++++ T+ ++LE+++ QA +
Sbjct: 1519 SKDDVGKNVHELEKS----------KRALETQMEEMKTQLEELEDEL---------QATE 1559
Query: 471 TRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKST 530
LR V+ + A+ + R +Q RDE + E R Q Q
Sbjct: 1560 DAKLRLEVN-----MQALKGQFERDLQA----------RDEQNE---EKRRQLQRQLHEY 1601
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTL 590
+ E+E +K +KL L E +A K + + + LQ+Q ++ L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 591 QD---TEDALSQDQLEQMILTEELQAIRQAIQGEL---ELRRKTDAAIREKLQEHMTSNK 644
+D + D + E + L+A +Q +L E RK +E+L E + S+
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 645 TTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKK 704
+ + LQ EK + ++++ + L+ Q + + V+K
Sbjct: 1722 SGRN------ALQDEKRRLEARIAQLEEE--------------LEEEQGNMEAMSDRVRK 1761
Query: 705 VNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLID 764
+ +E++ ++ + +QLER EL SKL +
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESA----RQQLERQNKELR--------------SKLHE 1803
Query: 765 EHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKK 824
+ + T L+ ++ ++ ++ E++ A+ K L ++K + ++E E+K
Sbjct: 1804 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1863
Query: 825 EQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASE---RETIK 881
++ + + + +K+L + + S+ + N R + E + +++E RE
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 882 MQDKLNQLSE 891
++ KL + +E
Sbjct: 1924 LKSKLRRGNE 1933
Score = 63.2 bits (152), Expect = 1e-09
Identities = 96/488 (19%), Positives = 200/488 (40%), Gaps = 53/488 (10%)
Query: 255 EGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELV 314
E A+ + E E +++ + E LV D V K L Q+E++K L+EL
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 315 VATKQSRAQRQELGVNLYEVQ-QHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALY 373
+ + + L VN+ ++ Q LQ E++ ++ + + E EL+ R
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER--- 1609
Query: 374 TKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVK-KAETERIRA 432
K A A +KK L+ ++++L L D ++ + Q+ K +A+ + +
Sbjct: 1610 -KQRALAAAAKKK---LEGDLKDLEL------QADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 433 EIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEK 492
E+E + D++ A++ E+ EA + ED +A +A +EK
Sbjct: 1660 ELEDARASR--DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA-------DLEK 1710
Query: 493 RRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLA 552
+ ++ ASSL G + R + + + + + G +EA + K ++ E+L+
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 553 SILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQ 612
N TE + QK + + L+ Q R L + E A+ + +
Sbjct: 1771 ---NELATERSTAQKNE----SARQQLERQNKELRSKLHEMEGAVK----------SKFK 1813
Query: 613 AIRQAIQGEL-ELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKIN 671
+ A++ ++ +L + + REK + + K +++L+++ E+ + +
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 672 GDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLIN 731
++R+ ++ L E +++ +++N Q E+ T E +N
Sbjct: 1874 -----------KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Query: 732 FLNKQLER 739
L +L R
Sbjct: 1923 ALKSKLRR 1930
Score = 54.7 bits (130), Expect = 5e-07
Identities = 63/282 (22%), Positives = 117/282 (41%), Gaps = 13/282 (4%)
Query: 842 KLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL- 900
K+ L+ R EE++ + R KA E E +++ K +QL+EEK L QL
Sbjct: 840 KVKPLLQVTR-QEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 901 ------VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQ 954
EAE + K Q +E+ +++ + + E R + + R K + Q +
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDL 955
Query: 955 EKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTK 1014
E+ + E A + + AE + K + D + +L RK+ + R + T
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER--ISDLTT 1013
Query: 1015 TVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKH 1074
+ E EE +N++ + + +S ++ E L LKR+ + ++
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 1075 LQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRD 1116
LQA + L + ++ L RLD +A L ++R+
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 119 bits (298), Expect = 2e-26
Identities = 169/790 (21%), Positives = 351/790 (44%), Gaps = 76/790 (9%)
Query: 293 AALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRH 352
AA N Q +L ++ L+ T+Q + Q L + ++ + L++ +H
Sbjct: 831 AAYLKLRNWQWWRLFTKVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH 889
Query: 353 AMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALH-----LFYMQNI 407
+ + E+ +E+LQA LY A A E R +LAA + E+E + LH L ++
Sbjct: 890 SQLTEEKNLLQEQLQAETELY----AEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDR 944
Query: 408 DQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRA--QQLEEDIALFEAQYL 465
Q ++ + + M Q + + E E E +Q L ++++T A ++LE++I + + Q
Sbjct: 945 GQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIM-------QQWASSLVGMKHRDEAHRAVLE 518
+++ ++L + +S+ T + A EK + + + S L ++E R LE
Sbjct: 1003 KLSKERKLLEERISDLTTNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 519 AL-RGCQHQAKSTDGEIEAYKKSI----MKEEEKNEKLASILNRTETEATLLQKLTTQCL 573
L R + A +I + I M+ +K E+L + L R + E + QK L
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE--IAQK--NNAL 1117
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIR 633
K L+ + + L A ++ + ++ L EEL+A++ ++ L+ T +R
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELR 1176
Query: 634 EKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQK 693
K ++ +T K K ++ + + M ++ ++ + + LD +++
Sbjct: 1177 AKREQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 694 TLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLE 753
TL + + D+ ++ ++ E+ + +E + + ER +EL ++V L+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-NDKVHKLQ 1293
Query: 754 LEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQE--QEEQLASLDASKKELHIMEQK 811
E++ ++ +++E +GKA++ L ++ + TQE QEE L+ S K L +E++
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEETRQKLNVSTK-LRQLEEE 1351
Query: 812 KLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRS 871
+ ++ ++++E + ++ +E H+ L+ L + + E LE+ + + E + +
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE-IEN 1410
Query: 872 LKASERETIKMQDKL----NQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEM---RSSV 924
L E DKL N+L +E L+ L + EKK + ++ ++
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 925 DSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRK 984
S+ RA + +EK +A+ LA A E + + E
Sbjct: 1471 SSKYADERDRAE--------------AEAREKETKALSLARALEEALEAKEE-------- 1508
Query: 985 ALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADF 1044
L RT+ L+ ++ D+ + D+ K V ELE+++R + + + E + +L ++ +
Sbjct: 1509 -LERTN-----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 1045 DTLEADLTRL 1054
E RL
Sbjct: 1563 QATEDAKLRL 1572
Score = 73.9 bits (180), Expect = 8e-13
Identities = 120/610 (19%), Positives = 242/610 (39%), Gaps = 97/610 (15%)
Query: 292 QAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDR 351
+AA + L + +L+ +L +LVV R L + Q L + + K D
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477
Query: 352 HAMASSERRQKEEE-LQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD 410
A +E R+KE + L ARAL + A E + L+ EME+L
Sbjct: 1478 RDRAEAEAREKETKALSLARAL-EEALEAKEELERTNKMLKAEMEDLV-----------S 1525
Query: 411 MRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAED 470
+DD+ ++K+ K+ + ++++ T+ ++LE+++ QA +
Sbjct: 1526 SKDDVGKNVHELEKS----------KRALETQMEEMKTQLEELEDEL---------QATE 1566
Query: 471 TRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKST 530
LR V+ + A+ + R +Q RDE + E R Q Q
Sbjct: 1567 DAKLRLEVN-----MQALKGQFERDLQA----------RDEQNE---EKRRQLQRQLHEY 1608
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTL 590
+ E+E +K +KL L E +A K + + + LQ+Q ++ L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 591 QD---TEDALSQDQLEQMILTEELQAIRQAIQGEL---ELRRKTDAAIREKLQEHMTSNK 644
+D + D + E + L+A +Q +L E RK +E+L E + S+
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 645 TTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKK 704
+ + LQ EK + ++++ + L+ Q + + V+K
Sbjct: 1729 SGRN------ALQDEKRRLEARIAQLEEE--------------LEEEQGNMEAMSDRVRK 1768
Query: 705 VNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLID 764
+ +E++ ++ + +QLER EL SKL +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESA----RQQLERQNKELR--------------SKLHE 1810
Query: 765 EHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKK 824
+ + T L+ ++ ++ ++ E++ A+ K L ++K + ++E E+K
Sbjct: 1811 MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK 1870
Query: 825 EQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASE---RETIK 881
++ + + + +K+L + + S+ + N R + E + +++E RE
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 882 MQDKLNQLSE 891
++ KL + +E
Sbjct: 1931 LKSKLRRGNE 1940
Score = 63.2 bits (152), Expect = 1e-09
Identities = 96/488 (19%), Positives = 200/488 (40%), Gaps = 53/488 (10%)
Query: 255 EGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELV 314
E A+ + E E +++ + E LV D V K L Q+E++K L+EL
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 315 VATKQSRAQRQELGVNLYEVQ-QHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALY 373
+ + + L VN+ ++ Q LQ E++ ++ + + E EL+ R
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER--- 1616
Query: 374 TKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVK-KAETERIRA 432
K A A +KK L+ ++++L L D ++ + Q+ K +A+ + +
Sbjct: 1617 -KQRALAAAAKKK---LEGDLKDLEL------QADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 433 EIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEK 492
E+E + D++ A++ E+ EA + ED +A +A +EK
Sbjct: 1667 ELEDARASR--DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA-------DLEK 1717
Query: 493 RRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLA 552
+ ++ ASSL G + R + + + + + G +EA + K ++ E+L+
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 553 SILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQ 612
N TE + QK + + L+ Q R L + E A+ + +
Sbjct: 1778 ---NELATERSTAQKNE----SARQQLERQNKELRSKLHEMEGAVK----------SKFK 1820
Query: 613 AIRQAIQGEL-ELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKIN 671
+ A++ ++ +L + + REK + + K +++L+++ E+ + +
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 672 GDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLIN 731
++R+ ++ L E +++ +++N Q E+ T E +N
Sbjct: 1881 -----------KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Query: 732 FLNKQLER 739
L +L R
Sbjct: 1930 ALKSKLRR 1937
Score = 54.7 bits (130), Expect = 5e-07
Identities = 63/282 (22%), Positives = 117/282 (41%), Gaps = 13/282 (4%)
Query: 842 KLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL- 900
K+ L+ R EE++ + R KA E E +++ K +QL+EEK L QL
Sbjct: 847 KVKPLLQVTR-QEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 901 ------VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQ 954
EAE + K Q +E+ +++ + + E R + + R K + Q +
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDL 962
Query: 955 EKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTK 1014
E+ + E A + + AE + K + D + +L RK+ + R + T
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER--ISDLTT 1020
Query: 1015 TVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKH 1074
+ E EE +N++ + + +S ++ E L LKR+ + ++
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 1075 LQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRD 1116
LQA + L + ++ L RLD +A L ++R+
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 119 bits (298), Expect = 2e-26
Identities = 169/790 (21%), Positives = 351/790 (44%), Gaps = 76/790 (9%)
Query: 293 AALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRH 352
AA N Q +L ++ L+ T+Q + Q L + ++ + L++ +H
Sbjct: 831 AAYLKLRNWQWWRLFTKVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH 889
Query: 353 AMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALH-----LFYMQNI 407
+ + E+ +E+LQA LY A A E R +LAA + E+E + LH L ++
Sbjct: 890 SQLTEEKNLLQEQLQAETELY----AEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDR 944
Query: 408 DQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRA--QQLEEDIALFEAQYL 465
Q ++ + + M Q + + E E E +Q L ++++T A ++LE++I + + Q
Sbjct: 945 GQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIM-------QQWASSLVGMKHRDEAHRAVLE 518
+++ ++L + +S+ T + A EK + + + S L ++E R LE
Sbjct: 1003 KLSKERKLLEERISDLTTNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 519 AL-RGCQHQAKSTDGEIEAYKKSI----MKEEEKNEKLASILNRTETEATLLQKLTTQCL 573
L R + A +I + I M+ +K E+L + L R + E + QK L
Sbjct: 1062 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE--IAQK--NNAL 1117
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIR 633
K L+ + + L A ++ + ++ L EEL+A++ ++ L+ T +R
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELR 1176
Query: 634 EKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQK 693
K ++ +T K K ++ + + M ++ ++ + + LD +++
Sbjct: 1177 AKREQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 694 TLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLE 753
TL + + D+ ++ ++ E+ + +E + + ER +EL ++V L+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-NDKVHKLQ 1293
Query: 754 LEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQE--QEEQLASLDASKKELHIMEQK 811
E++ ++ +++E +GKA++ L ++ + TQE QEE L+ S K L +E++
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEETRQKLNVSTK-LRQLEEE 1351
Query: 812 KLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRS 871
+ ++ ++++E + ++ +E H+ L+ L + + E LE+ + + E + +
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE-IEN 1410
Query: 872 LKASERETIKMQDKL----NQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEM---RSSV 924
L E DKL N+L +E L+ L + EKK + ++ ++
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 925 DSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRK 984
S+ RA + +EK +A+ LA A E + + E
Sbjct: 1471 SSKYADERDRAE--------------AEAREKETKALSLARALEEALEAKEE-------- 1508
Query: 985 ALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADF 1044
L RT+ L+ ++ D+ + D+ K V ELE+++R + + + E + +L ++ +
Sbjct: 1509 -LERTN-----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 1045 DTLEADLTRL 1054
E RL
Sbjct: 1563 QATEDAKLRL 1572
Score = 115 bits (288), Expect = 2e-25
Identities = 212/1004 (21%), Positives = 415/1004 (41%), Gaps = 154/1004 (15%)
Query: 238 EGDLPVFQDQIQQPSTEEGAMAERVESEGSD-EEAEDEGSQLVVLDPDHPLMV-RFQAAL 295
E ++ V DQ + S E + ER+ ++ E E++ L L H M+ + L
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 296 KNY--LNRQIEKLK--------------LDLQELVVATKQSRAQRQE-LGVNLYEVQQHL 338
K +++EKLK DLQ + K A+++E L L + +
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 339 VHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLA 398
L+K + S +E+L + RA K + ++L AL+TE+E+
Sbjct: 1111 AQKNNALKKIRELEGHISD----LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166
Query: 399 LHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQD--LYVDQLTTRAQQ---- 452
Q + ++ V+ + + + ET A++++ +Q V++LT + +Q
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225
Query: 453 ---LEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHR 509
L+++ E + A + R+L +A E + +K+++ Q
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQE-------VEHKKKKLEAQVQELQSKCSDG 1278
Query: 510 DEAHRAVLEALRGCQHQAKSTDGEI-EAYKKSIMKEEEKNEKLASILNRTETEATLLQKL 568
+ A + + + Q++ +S G + EA K+I ++ +AS+ ++ + LLQ+
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD----VASLSSQLQDTQELLQEE 1334
Query: 569 TTQCLTKQVALQSQFNTYRLTLQDT--EDALSQDQLEQMILT------------------ 608
T Q L L+ Q R +LQD E+ ++ LE+ I T
Sbjct: 1335 TRQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393
Query: 609 -EELQAIRQAIQGELE---LRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMM 664
E L+ ++ Q E+E + + AA +KL++ T N+ + + L++ L ++ ++
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK--TKNRLQQELDDLVVDLDNQR-QLV 1450
Query: 665 THLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNEL-ITNSQSEISRRTILI 723
++L K Q + + SS+ A ++ E + K+ L + + E +
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKY-ADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 724 ERKQGLINFLNKQLERMVSELGGEEVGP-----------LELEIKRLSKLIDEHDGKAVQ 772
ER + L ++E +VS ++VG LE +++ + ++E + +
Sbjct: 1510 ERTNKM---LKAEMEDLVSSK--DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 773 AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLR-VESKIEQEKKEQ----- 826
+ LRL+ M + + E L + D +E Q++L E+++E E+K++
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1624
Query: 827 --KEIEHHMKDLD-----------NDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLK 873
K++E +KDL+ +K+L L + + ELE + R + +E + K
Sbjct: 1625 AKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAK 1683
Query: 874 ASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEI 933
+E++ ++ L QL E+ A +A+ + K +LA+E+ SS+
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLE------KEELAEELASSLSGR------ 1731
Query: 934 RAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAE---GQRKMDRKALTRTD 990
A++ E R++ R+ QL ++ E+ ME R T QAE + +R + +
Sbjct: 1732 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 991 FHHKQLE-----LRRKIRDVRKATDECTKTVL-----ELEETQRNVSSSLLEKQEKLSVI 1040
+QLE LR K+ ++ A K+ + ++ + + V EKQ +
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 1041 QADFDTLEADLTRLGALKRQNLSEIVA-LQTRLKHLQAVKEGRYVFLFRSKQ--SLVLER 1097
+ K + L EI+ ++ K + KE R KQ + E
Sbjct: 1852 KQ---------------KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 1098 QRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPGP 1141
+ +R+ L R DE + EA+ + + +KL P P
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940
Score = 54.7 bits (130), Expect = 5e-07
Identities = 63/282 (22%), Positives = 117/282 (41%), Gaps = 13/282 (4%)
Query: 842 KLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL- 900
K+ L+ R EE++ + R KA E E +++ K +QL+EEK L QL
Sbjct: 847 KVKPLLQVTR-QEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 901 ------VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQ 954
EAE + K Q +E+ +++ + + E R + + R K + Q +
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDL 962
Query: 955 EKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTK 1014
E+ + E A + + AE + K + D + +L RK+ + R + T
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER--ISDLTT 1020
Query: 1015 TVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKH 1074
+ E EE +N++ + + +S ++ E L LKR+ + ++
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 1075 LQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRD 1116
LQA + L + ++ L RLD +A L ++R+
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 119 bits (298), Expect = 2e-26
Identities = 169/790 (21%), Positives = 351/790 (44%), Gaps = 76/790 (9%)
Query: 293 AALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRH 352
AA N Q +L ++ L+ T+Q + Q L + ++ + L++ +H
Sbjct: 824 AAYLKLRNWQWWRLFTKVKPLLQVTRQEE-EMQAKEDELQKTKERQQKAENELKELEQKH 882
Query: 353 AMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALH-----LFYMQNI 407
+ + E+ +E+LQA LY A A E R +LAA + E+E + LH L ++
Sbjct: 883 SQLTEEKNLLQEQLQAETELY----AEAEEMRVRLAAKKQELEEI-LHEMEARLEEEEDR 937
Query: 408 DQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRA--QQLEEDIALFEAQYL 465
Q ++ + + M Q + + E E E +Q L ++++T A ++LE++I + + Q
Sbjct: 938 GQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIM-------QQWASSLVGMKHRDEAHRAVLE 518
+++ ++L + +S+ T + A EK + + + S L ++E R LE
Sbjct: 996 KLSKERKLLEERISDLTTNL-AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 519 AL-RGCQHQAKSTDGEIEAYKKSI----MKEEEKNEKLASILNRTETEATLLQKLTTQCL 573
L R + A +I + I M+ +K E+L + L R + E + QK L
Sbjct: 1055 KLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE--IAQK--NNAL 1110
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIR 633
K L+ + + L A ++ + ++ L EEL+A++ ++ L+ T +R
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELR 1169
Query: 634 EKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQK 693
K ++ +T K K ++ + + M ++ ++ + + LD +++
Sbjct: 1170 AKREQEVTVLK--KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 694 TLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLE 753
TL + + D+ ++ ++ E+ + +E + + ER +EL ++V L+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL-NDKVHKLQ 1286
Query: 754 LEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQE--QEEQLASLDASKKELHIMEQK 811
E++ ++ +++E +GKA++ L ++ + TQE QEE L+ S K L +E++
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQL-QDTQELLQEETRQKLNVSTK-LRQLEEE 1344
Query: 812 KLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRS 871
+ ++ ++++E + ++ +E H+ L+ L + + E LE+ + + E + +
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE-IEN 1403
Query: 872 LKASERETIKMQDKL----NQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEM---RSSV 924
L E DKL N+L +E L+ L + EKK + ++ ++
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 925 DSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRK 984
S+ RA + +EK +A+ LA A E + + E
Sbjct: 1464 SSKYADERDRAE--------------AEAREKETKALSLARALEEALEAKEE-------- 1501
Query: 985 ALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADF 1044
L RT+ L+ ++ D+ + D+ K V ELE+++R + + + E + +L ++ +
Sbjct: 1502 -LERTN-----KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 1045 DTLEADLTRL 1054
E RL
Sbjct: 1556 QATEDAKLRL 1565
Score = 115 bits (288), Expect = 2e-25
Identities = 212/1004 (21%), Positives = 415/1004 (41%), Gaps = 154/1004 (15%)
Query: 238 EGDLPVFQDQIQQPSTEEGAMAERVESEGSD-EEAEDEGSQLVVLDPDHPLMV-RFQAAL 295
E ++ V DQ + S E + ER+ ++ E E++ L L H M+ + L
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 296 KNY--LNRQIEKLK--------------LDLQELVVATKQSRAQRQE-LGVNLYEVQQHL 338
K +++EKLK DLQ + K A+++E L L + +
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 339 VHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLA 398
L+K + S +E+L + RA K + ++L AL+TE+E+
Sbjct: 1104 AQKNNALKKIRELEGHISD----LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159
Query: 399 LHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQD--LYVDQLTTRAQQ---- 452
Q + ++ V+ + + + ET A++++ +Q V++LT + +Q
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218
Query: 453 ---LEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHR 509
L+++ E + A + R+L +A E + +K+++ Q
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQE-------VEHKKKKLEAQVQELQSKCSDG 1271
Query: 510 DEAHRAVLEALRGCQHQAKSTDGEI-EAYKKSIMKEEEKNEKLASILNRTETEATLLQKL 568
+ A + + + Q++ +S G + EA K+I ++ +AS+ ++ + LLQ+
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD----VASLSSQLQDTQELLQEE 1327
Query: 569 TTQCLTKQVALQSQFNTYRLTLQDT--EDALSQDQLEQMILT------------------ 608
T Q L L+ Q R +LQD E+ ++ LE+ I T
Sbjct: 1328 TRQKLNVSTKLR-QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386
Query: 609 -EELQAIRQAIQGELE---LRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMM 664
E L+ ++ Q E+E + + AA +KL++ T N+ + + L++ L ++ ++
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK--TKNRLQQELDDLVVDLDNQR-QLV 1443
Query: 665 THLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNEL-ITNSQSEISRRTILI 723
++L K Q + + SS+ A ++ E + K+ L + + E +
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKY-ADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 724 ERKQGLINFLNKQLERMVSELGGEEVGP-----------LELEIKRLSKLIDEHDGKAVQ 772
ER + L ++E +VS ++VG LE +++ + ++E + +
Sbjct: 1503 ERTNKM---LKAEMEDLVSSK--DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 773 AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLR-VESKIEQEKKEQ----- 826
+ LRL+ M + + E L + D +E Q++L E+++E E+K++
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAA 1617
Query: 827 --KEIEHHMKDLD-----------NDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLK 873
K++E +KDL+ +K+L L + + ELE + R + +E + K
Sbjct: 1618 AKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAK 1676
Query: 874 ASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEI 933
+E++ ++ L QL E+ A +A+ + K +LA+E+ SS+
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLE------KEELAEELASSLSGR------ 1724
Query: 934 RAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAE---GQRKMDRKALTRTD 990
A++ E R++ R+ QL ++ E+ ME R T QAE + +R + +
Sbjct: 1725 NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 991 FHHKQLE-----LRRKIRDVRKATDECTKTVL-----ELEETQRNVSSSLLEKQEKLSVI 1040
+QLE LR K+ ++ A K+ + ++ + + V EKQ +
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 1041 QADFDTLEADLTRLGALKRQNLSEIVA-LQTRLKHLQAVKEGRYVFLFRSKQ--SLVLER 1097
+ K + L EI+ ++ K + KE R KQ + E
Sbjct: 1845 KQ---------------KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 1098 QRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLESPGP 1141
+ +R+ L R DE + EA+ + + +KL P P
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
Score = 54.7 bits (130), Expect = 5e-07
Identities = 63/282 (22%), Positives = 117/282 (41%), Gaps = 13/282 (4%)
Query: 842 KLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL- 900
K+ L+ R EE++ + R KA E E +++ K +QL+EEK L QL
Sbjct: 840 KVKPLLQVTR-QEEEMQAKEDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 901 ------VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQ 954
EAE + K Q +E+ +++ + + E R + + R K + Q +
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDL 955
Query: 955 EKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTK 1014
E+ + E A + + AE + K + D + +L RK+ + R + T
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER--ISDLTT 1013
Query: 1015 TVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKH 1074
+ E EE +N++ + + +S ++ E L LKR+ + ++
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 1075 LQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRD 1116
LQA + L + ++ L RLD +A L ++R+
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 116 bits (290), Expect = 1e-25
Identities = 156/757 (20%), Positives = 332/757 (43%), Gaps = 85/757 (11%)
Query: 331 LYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAAL 390
L +V++ + + L + + +E+ Q +E+LQA T+ CA A E R +L A
Sbjct: 854 LVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE----TELCAEAEELRARLTAK 909
Query: 391 QTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKK--AETERIRAEIEKKKQDLYVDQLTT 448
+ E+E + L +++ ++ + +++ E E E E +Q L ++++TT
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 449 RA--QQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIM------QQWA 500
A ++LEE+ + E Q A++ ++L ++E T + + + + +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 501 SSLVGMKHRDEAHRAVLEALRGCQHQAKSTD-----GEIEAYKKSI-MKEEEKNEKLASI 554
+ L R+E R LE R + + STD E++A + M+ +K E+L +
Sbjct: 1030 TDLEERLRREEKQRQELEKTRR-KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088
Query: 555 LNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAI 614
L R E EA QK L K L+SQ + + L+ + ++ + ++ L EEL+A+
Sbjct: 1089 LARVEEEAA--QK--NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEAL 1144
Query: 615 RQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDI 674
+ ++ L+ A +++L+ +K + N L L++E TH ++I
Sbjct: 1145 KTELEDTLD-----STAAQQELR-----SKREQEVNILKKTLEEE---AKTHEAQIQEMR 1191
Query: 675 AQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLN 734
+ + + + +L+ ++ L+ K + + N + E++ ++ + +G
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLE----KAKQTLENERGELANEVKVLLQGKGDSEHKR 1247
Query: 735 KQLERMVSELG-------------GEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQ 781
K++E + EL ++V L++E+ ++ L+ + D K+ + + L+
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 782 ---QEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDN 838
Q+ ++ QE+ Q SL K+ +E +K ++E+E++ + +E + L
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQ---VEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 839 DLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEE-KATLL 897
+ + M + E E+ R + + + L E + DKL + + L
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKD-LEGLSQRHEEKVAAYDKLEKTKTRLQQELD 1423
Query: 898 NQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKM 957
+ LV+ +HQ + L K+ + D + + + + K R + + +EK
Sbjct: 1424 DLLVDLDHQ---RQSACNLEKKQK-KFDQLLAEEKTISAKYAEERDRAE----AEAREKE 1475
Query: 958 IRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVL 1017
+A+ LA A E + +AE +R + R ++ D+ + D+ K+V
Sbjct: 1476 TKALSLARALEEAMEQKAELER--------------LNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 1018 ELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRL 1054
ELE+++R + + E + +L ++ + E RL
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558
Score = 116 bits (290), Expect = 1e-25
Identities = 180/927 (19%), Positives = 392/927 (42%), Gaps = 92/927 (9%)
Query: 245 QDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIE 304
Q+Q+Q TE A AE + + + ++ E E + H L R + + + Q E
Sbjct: 886 QEQLQA-ETELCAEAEELRARLTAKKQELE-------EICHDLEARVEEEEERCQHLQAE 937
Query: 305 KLKL--DLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQK 362
K K+ ++QEL ++ + RQ+L + + L L++ D++ + E++
Sbjct: 938 KKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
Query: 363 EEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVV 422
E+ + A +T E+ K LA L+ + E + L + R+ +
Sbjct: 998 EDRI----AEFTTNLTEEEEKSKSLAKLKNKHEAMITDL------------EERLRREEK 1041
Query: 423 KKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEAC 482
++ E E+ R ++E DL DQ+ +L+ IA + Q + E+ + V E
Sbjct: 1042 QRQELEKTRRKLEGDSTDLS-DQIA----ELQAQIAELKMQLAKKEEELQAALARVEEEA 1096
Query: 483 TEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIM 542
+ + ++++K R ++ S L + A R E Q + E+EA K +
Sbjct: 1097 AQKN-MALKKIRELESQISELQEDLESERASRNKAEK------QKRDLGEELEALKTELE 1149
Query: 543 KEEEKNEKLASILNRTETEATLLQK-LTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQ 601
+ + ++ E E +L+K L + T + +Q + +++ + L Q +
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 602 L--------------EQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTK 647
E+ L E++ + Q R+K +A ++E + +
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT 1269
Query: 648 YFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNE 707
+ +LQ E N+ LS+ + ++ T D + S+L Q+ L E ++ ++
Sbjct: 1270 ELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLST 1329
Query: 708 LITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGG------EEVGPLEL--EIKR- 758
+ + E + +E ++ + L KQ+ + +++ + VG LE E+KR
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK 1389
Query: 759 LSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESK 818
L K ++ + + + +L++ ++ QE ++ L LD ++ +E+K+ + +
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449
Query: 819 IEQEK-------KEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRS 871
+ +EK +E+ E ++ + L + + ELE+ N+ E +
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE-MED 1508
Query: 872 LKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKE--MRSSVDSEIG 929
L +S+ + K +++L + K L Q+ E + Q+ E ++Q ++ +R V+ +
Sbjct: 1509 LMSSKDDVGK---SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 930 QTEI-RAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKAL-T 987
+ + R ++G + + + QL++Q +M +E ++ ++ A + +MD K L
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE-DERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 988 RTDFHHKQL-ELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDT 1046
D +K E +++R ++ +C + + + ++ + + E ++KL ++A+
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 1047 LEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVL-ERQRLDKRLA 1105
L+ +L KRQ E L + + K +L L E++RL+ R+A
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSS------------GKGALALEEKRRLEARIA 1732
Query: 1106 LIATILDRVRDEYPQFQEALHKVSQMI 1132
+ L+ + + L K + I
Sbjct: 1733 QLEEELEEEQGNTELINDRLKKANLQI 1759
Score = 107 bits (266), Expect = 8e-23
Identities = 179/930 (19%), Positives = 373/930 (40%), Gaps = 145/930 (15%)
Query: 243 VFQDQIQQPSTEEGAMAERV-ESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNR 301
+ +DQ + + E+ + +R+ E + E E++ L L H M+ L
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI-------TDLEE 1034
Query: 302 QIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQ 361
++ + + QEL ++ +L + E+Q + L+ L K
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK-------------- 1080
Query: 362 KEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFY-------MQNIDQDMRDD 414
KEEELQAA A + A N KK+ L++++ L L + +D+ ++
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140
Query: 415 IRVM-TQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRI 473
+ + T++ ++ + E+ K++ ++ + LEE+ EAQ +
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQ----EVNILKKTLEEEAKTHEAQI-------QE 1189
Query: 474 LRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKH-RDEAHRAVLEALRG---CQHQAKS 529
+R+ S+A E+ + +R+ + +++ R E V L+G +H+ K
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 530 TDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLT 589
+ +++ + + E +LA + + + E + L +Q +K L F+
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 590 LQDTEDALSQDQLEQMILTEELQAI-------RQAIQGELELRRKTD----------AAI 632
LQDT++ L ++ +++ L+ +L+ + R+ ++ E E + + A +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 633 REKLQEHMTSNKTTKYFNQLILR------------------LQKEKTNMMTHLSKINGDI 674
++K+++ + +T + + + + L+K KT + L + D+
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429
Query: 675 ---AQTTLDITHTSSRLD---AHQKTLV-----ELDQDVKKVNELITNSQSEISRRTILI 723
Q+ ++ + D A +KT+ E D+ + E T + S +
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489
Query: 724 ERKQGLINFLNKQLERMVSEL--GGEEVGP-----------LELEIKRLSKLIDEHDGKA 770
E+K L LNKQ + +L ++VG LE +++ + ++E + +
Sbjct: 1490 EQKAELER-LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 771 VQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLR-VESKIEQEKKEQ--- 826
+ LRL+ + + + E L D +E +++R +E+++E E+K++
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 827 ----KEIEHHMKDL-----------DNDLKKLNMLMNKNRCSSEELEQNNRVTEN----- 866
K++E +KDL D +K+L L + + EL+ E
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA 1668
Query: 867 -EFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVD 925
E + LK+ E E I++Q++L K + E +I K LA E + ++
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 926 SEIGQTE--IRAMKGEIHRMKVRLGQLLKQQEKMIRAMELA---VARRETVTTQAEGQRK 980
+ I Q E + +G + RL + Q +++ + L + E Q E Q K
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788
Query: 981 ------MDRKALTRTDFHHKQLELRRKIRDVRKATDECTK----TVLELEETQRNVSSSL 1030
+ + ++ + L KI + + D TK ++ T++ + L
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL 1848
Query: 1031 LEKQEKLSVIQADFDTLEADLTRLGALKRQ 1060
L+ ++ + D + TRL LKRQ
Sbjct: 1849 LQVDDERRNAEQYKDQADKASTRLKQLKRQ 1878
Score = 90.5 bits (223), Expect = 8e-18
Identities = 146/753 (19%), Positives = 317/753 (42%), Gaps = 131/753 (17%)
Query: 304 EKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKE 363
+K++ LQEL V + R EL + ++Q L ++ LL +S + + + + E
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 364 EELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVK 423
+LQ + L EE ++ +L T+++ + +D ++ R +
Sbjct: 1308 SQLQDTQELL-------QEENRQKLSLSTKLKQV-----------EDEKNSFREQLE--- 1346
Query: 424 KAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAE---DTRILRKAVSE 480
E E + +EK+ L+ Q+ +++E+ + E + + D L + E
Sbjct: 1347 --EEEEAKHNLEKQIATLHA-QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403
Query: 481 ACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKS 540
D + K R+ Q+ LV + H+ ++ + + K D + K
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS-------ACNLEKKQKKFDQLLAEEKTI 1456
Query: 541 IMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD 600
K E+ ++ + ET+A L + + + ++ L+ +R ++D S+D
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS--SKD 1514
Query: 601 QLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEK 660
+ + + EL+ ++A++ ++E KT E+L++ + + + K ++ L+ K
Sbjct: 1515 DVGKSV--HELEKSKRALEQQVE-EMKTQL---EELEDELQATEDAKLRLEVNLQAMK-- 1566
Query: 661 TNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRT 720
AQ D+ + + +K LV ++V E+ + E +R+
Sbjct: 1567 --------------AQFERDLQGRDEQSEEKKKQLV------RQVREMEAELEDERKQRS 1606
Query: 721 ILIERKQGL----------INFLNKQLERMVSELGGEEVGPLELEIKRLSKLID------ 764
+ + ++ L I+ NK + + +L L+ ++K + +D
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR-----KLQAQMKDCMRELDDTRASR 1661
Query: 765 --------EHDGKAVQAQVTWLRLQQEMV------KVTQEQEEQLAS--LDASKKELHIM 808
E++ K + ++LQ+E+ + Q++ ++LA ++S K +
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721
Query: 809 EQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMN--------------KNRCSS 854
E+K+ R+E++I Q ++E +E + + + +++ LKK N+ ++ KN +
Sbjct: 1722 EEKR-RLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
Query: 855 EELEQNN---RVTENEFVRSLKASERETI-KMQDKLNQLSEEKATLLNQLVEAEHQIMLW 910
++LE+ N +V E ++K+ + +I ++ K+ QL E+ + A Q+
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 911 EKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRET 970
EKK+ K++ VD E E K + + RL QL +Q E+ + A A R
Sbjct: 1841 EKKL---KDVLLQVDDERRNAE--QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRK 1895
Query: 971 VTTQAEGQRKMDRKALTRTDFHHKQLELRRKIR 1003
+ QR+++ T + + L+ K+R
Sbjct: 1896 L------QRELEDATETADAMNREVSSLKNKLR 1922
Score = 80.9 bits (198), Expect = 6e-15
Identities = 119/616 (19%), Positives = 254/616 (41%), Gaps = 100/616 (16%)
Query: 533 EIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTY------ 586
++ ++ +M +EE+ K+ E T ++ L +Q + +++ LQ Q
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 587 ------RLTLQ---------DTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAA 631
RLT + D E + +++ L E + ++Q IQ ELE + + + +
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ-ELEEQLEEEES 957
Query: 632 IREKLQ-EHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDA 690
R+KLQ E +T+ K + + L+ + + + IA+ T ++T +
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK--- 1014
Query: 691 HQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVG 750
K+L +L K +IT+ + + R E KQ ++LE+ +L G+
Sbjct: 1015 -SKSLAKLKN---KHEAMITDLEERLRR-----EEKQ------RQELEKTRRKLEGDSTD 1059
Query: 751 PLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQ 810
LS I E + + ++ + ++E+ EE+ A + + K++ +E
Sbjct: 1060 --------LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 811 KKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVR 870
+ ++ +E E+ + + E +DL +L+ L + ++ S +Q R + V
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTEL-EDTLDSTAAQQELRSKREQEVN 1170
Query: 871 SLKASERETIKMQD-KLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIG 929
LK + E K + ++ ++ ++ + + +L E Q + ++ AK+ ++++E G
Sbjct: 1171 ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ---TLENERG 1227
Query: 930 QTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRT 989
+ +A V Q +G + RK +
Sbjct: 1228 E----------------------------------LANEVKVLLQGKGDSEHKRKKV-EA 1252
Query: 990 DFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEA 1049
Q++ R + D+ TK +EL+ NV+ L + K S + DF LE+
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVELD----NVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 1050 DLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIAT 1109
L L ++ + ++L T+LK ++ K L +++ + L+K+ IAT
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA----KHNLEKQ---IAT 1361
Query: 1110 ILDRVRDEYPQFQEAL 1125
+ +V D + ++++
Sbjct: 1362 LHAQVADMKKKMEDSV 1377
Score = 31.2 bits (69), Expect = 5.9
Identities = 19/87 (21%), Positives = 42/87 (48%), Gaps = 4/87 (4%)
Query: 301 RQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERR 360
+Q+ + + L+++++ R ++ + L L++ LE++ + A++ RR
Sbjct: 1835 KQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRR 1894
Query: 361 QKEEELQAARALYTKTCAAANEERKKL 387
+ + EL+ A T+T A N E L
Sbjct: 1895 KLQRELEDA----TETADAMNREVSSL 1917
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 114 bits (286), Expect = 4e-25
Identities = 158/781 (20%), Positives = 344/781 (44%), Gaps = 92/781 (11%)
Query: 310 LQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAA 369
++ L+ T+Q + Q L +V++ ++ LE+ +H E+ E+LQA
Sbjct: 841 VKPLLQVTRQEE-ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 370 RALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETER 429
L+ A A E R +LAA + E+E + LH + +++ R+ I + +A +
Sbjct: 900 TELF----AEAEEMRARLAAKKQELEEI-LHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 430 IRAEIEKK---KQDLYVDQLTTRAQ--QLEEDIALFEAQYLAQAEDTRILRKAVSEACTE 484
+ +++++ +Q L ++++T A+ ++EE+I L E Q ++ +++ ++E ++
Sbjct: 955 LEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014
Query: 485 I-----DAISVEKRRIMQQ-WASSLVGMKHRDEAHRAVLEALR--------GCQHQAKST 530
+ A ++ K R Q+ S L ++E R LE + Q Q
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL 1074
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTL 590
+I+ K + K+EE+ L L R + E L K + ++ LQ+Q +
Sbjct: 1075 QAQIDELKLQLAKKEEE---LQGALARGDDET--LHKNNALKVVRE--LQAQIAELQEDF 1127
Query: 591 QDTEDALSQDQLEQMILTEELQAIRQ---------AIQGELELRRKTDAAIREKLQEHMT 641
+ + + ++ + ++ L+EEL+A++ A Q EL +R+ + A +K E T
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 642 SNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQD 701
N + +Q + T L +++ + Q + + EL +
Sbjct: 1188 KNHEAQ--------IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 702 VKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSK 761
VK + ++ S+ + + ++ ++ + +R+ EL E+ L+ E+ +S
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVS----EGDRLRVELA-EKASKLQNELDNVST 1294
Query: 762 LIDEHDGKAVQAQVTWLRLQQEMVKVTQE--QEEQLASLDASKKELHIMEQKKLRVESKI 819
L++E + K ++ L+ ++ + TQE QEE L+ S + + +E++K ++ +
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQL-QDTQELLQEETRQKLNLSSR-IRQLEEEKNSLQEQQ 1352
Query: 820 EQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERET 879
E+E++ +K +E + L + L ++ + + E LE+ ++++
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE---------------AKKKL 1397
Query: 880 IKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGE 939
+K + L+Q EEKA ++L + ++++ Q ++ +D + R +
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQ------QELDDLTVDLDHQ------RQVASN 1445
Query: 940 IHRMKVRLGQLLKQQEKMIRAM------ELAVARRETVTTQAEGQRKMDRKALTRTDFHH 993
+ + + + QLL + EK I A RE T R ++ + +F
Sbjct: 1446 LEKKQKKFDQLLAE-EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFER 1504
Query: 994 KQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTR 1053
+ +LR + D+ + D+ K V ELE+++R + + E + +L ++ + E R
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 1054 L 1054
L
Sbjct: 1565 L 1565
Score = 110 bits (274), Expect = 1e-23
Identities = 170/933 (18%), Positives = 380/933 (40%), Gaps = 76/933 (8%)
Query: 238 EGDLPVFQDQIQQPSTEEGAMAERVESEGS-DEEAEDEGSQLVVLDPD-----HPL--MV 289
EG+L + + QQ E+ +AE++++E EAE+ ++L + H L V
Sbjct: 872 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931
Query: 290 RFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSH 349
+ L + +K++ +Q+L + RQ+L + + + +++ +
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991
Query: 350 DRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQ 409
D+++ E++ E+ + A + A E+ K LA ++ + E + L ++
Sbjct: 992 DQNSKFIKEKKLMEDRI----AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE 1047
Query: 410 DMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAE 469
R ++ + +K + E + + + +D+L + + EE++ LA+ +
Sbjct: 1048 KTRQELE---KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL----QGALARGD 1100
Query: 470 DTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALR-------- 521
D + + + E+ A E + + +S + + LEAL+
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 522 --GCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVAL 579
Q + ++ + A K ++EE KN + A I + + AT L++L+ Q
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHE-AQIQDMRQRHATALEELSEQL------- 1212
Query: 580 QSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEH 639
Q ++ L+ + L D E L E++ ++Q R+K DA ++E +
Sbjct: 1213 -EQAKRFKANLEKNKQGLETDNKE---LACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Query: 640 MTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELD 699
++ + +LQ E N+ T L + + D S+L Q+ L E
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328
Query: 700 QDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELG------GEEVGPLE 753
+ ++ I + E + E ++ L KQ+ + S+L +++G +E
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE 1388
Query: 754 LEIKRLSKLIDEHDG---KAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQ 810
+ KL+ + + + + + + +L++ ++ QE ++ LD ++ +E+
Sbjct: 1389 SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEK 1448
Query: 811 KKLRVESKIEQEK-------KEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRV 863
K+ + + + +EK +E+ E ++ + L + + + EE E+ N+
Sbjct: 1449 KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQ 1508
Query: 864 TENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSS 923
+ + L +S+ + K +++L + K L Q+ E Q+ E ++Q ++ +
Sbjct: 1509 LRAD-MEDLMSSKDDVGK---NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 924 VDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDR 983
+ + ++AMK + R L + E+ L + + + + E +RK
Sbjct: 1565 L-----EVNMQAMKAQFER------DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 984 KAL-TRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQA 1042
A+ ++ +L +I KA DE K + +L+ ++ L E + I A
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 1043 DFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRS---KQSLVLERQR 1099
E L L A Q E+ + + +H + ++ + S K +L+ E++R
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733
Query: 1100 LDKRLALIATILDRVRDEYPQFQEALHKVSQMI 1132
L+ R+A + L+ + + K + +
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTLQV 1766
Score = 99.0 bits (245), Expect = 2e-20
Identities = 173/907 (19%), Positives = 374/907 (41%), Gaps = 90/907 (9%)
Query: 189 EEPQGQVLPMGVQHRFRLSHGSDIESS-DLEEFVSQEPVIPPGVPDAHPR--EGDLPVFQ 245
EE + Q+L + + +H D+E D EE Q+ + +A + E ++ + +
Sbjct: 934 EEERNQILQN--EKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991
Query: 246 DQIQQPSTEEGAMAERV-ESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIE 304
DQ + E+ M +R+ E E E++ L + +M+ + L +++
Sbjct: 992 DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMI-------SDLEERLK 1044
Query: 305 KLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEE 364
K + QEL A ++ + +L + E+Q + L+ L K KEE
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK--------------KEE 1090
Query: 365 ELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKK 424
ELQ A A N K + LQ ++ L +D +
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAEL----------QEDFESE---------- 1130
Query: 425 AETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTE 484
+ R +AE +K+ ++ L T + + A + + ++ L+KA+ E
Sbjct: 1131 -KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKN 1189
Query: 485 IDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEA-LRGCQHQAKSTDGEIEAYKKSIMK 543
+A + R+ L + + +A LE +G + K E++ ++ +
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 544 EEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLE 603
E K +KL + + + + +L + K LQ++ + L++ E + +
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 604 QMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNM 663
L +LQ ++ +Q E + + IR+ L+E S + Q+E+
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNLSSRIRQ-LEEEKNS----------LQEQQEEEEEA 1358
Query: 664 MTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILI 723
+L K + + T ++D T+ L++ KK+ + + + +
Sbjct: 1359 RKNLEK---QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 724 ERKQGLINFLNKQLERMVSELGGEE--VGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQ 781
++ + N L ++L+ + +L + LE + K+ +L+ E K++ A+ R +
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE--KSISARYAEERDR 1473
Query: 782 QEMVKVTQEQEEQLASLDASKKEL----HIMEQKKLRVESKIEQEKKEQKEIEHHMKDLD 837
E +E+E + SL + +E E++ ++ + +E + ++ ++ +L+
Sbjct: 1474 AE--AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 838 NDLKKLNMLMNKNRCSSEELEQNNRVTENEFVR------SLKASERETIKMQDKLNQLSE 891
+ L + + R EELE + TE+ +R ++KA ++ +D+ N+ E
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE--E 1589
Query: 892 EKATLLNQL--VEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQ 949
+K L+ Q+ +EAE + ++ + +A + + +D + + +I A + +L +
Sbjct: 1590 KKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRK 1649
Query: 950 LLKQQEKMIRAMELAVARRETVTTQA-EGQRKMDRKALTRTDFHHKQLELRRKIRDVRKA 1008
L Q + R +E A A R+ + Q+ E ++K+ K+L + Q EL R R A
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKESEKKL--KSL-EAEILQLQEELASSERARRHA 1706
Query: 1009 TDECTKTVLELEETQRNVSSSLLEK---QEKLSVIQADFDTLEADLTRLGALKRQNLSEI 1065
E + E+ + S+ L EK + +++ ++ + + ++++ L R+ ++
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV 1766
Query: 1066 VALQTRL 1072
L L
Sbjct: 1767 DTLNAEL 1773
Score = 93.2 bits (230), Expect = 1e-18
Identities = 157/830 (18%), Positives = 341/830 (41%), Gaps = 107/830 (12%)
Query: 245 QDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLD-PDHPLMVRFQAALKNYLNRQI 303
QD Q+ +T ++E++E + ++ Q + D + V+ +K +
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 304 EKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKE 363
+KL +QEL + R EL ++Q L ++ LLE++ + + + E
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 364 EELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVK 423
+LQ + L + E R+KL NL+ + ++ +++ +
Sbjct: 1315 SQLQDTQELLQE------ETRQKL--------NLSSRIRQLEEEKNSLQE---------Q 1351
Query: 424 KAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQ---AEDTRILRKAVSE 480
+ E E R +EK+ L QL +++++D+ E+ A+ +D L + + E
Sbjct: 1352 QEEEEEARKNLEKQVLALQ-SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 481 ACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKS 540
D + K R+ Q+ V + H+ R V L + + K D + K
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQ----RQVASNL---EKKQKKFDQLLAEEKSI 1463
Query: 541 IMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD 600
+ E+ ++ + ET+A L + + L + + Q R ++D S+D
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS--SKD 1521
Query: 601 QLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEK 660
+ + + EL+ ++A++ ++E R E+L++ + + + K LRL+
Sbjct: 1522 DVGKNV--HELEKSKRALEQQVEEMRTQ----LEELEDELQATEDAK------LRLE--- 1566
Query: 661 TNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRT 720
NM ++ D+ T + +K L+ +K+V EL + E +R
Sbjct: 1567 VNMQAMKAQFERDL--------QTRDEQNEEKKRLL-----IKQVRELEAELEDERKQRA 1613
Query: 721 ILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRL 780
+ + K K++E ++ LE +I+ +K DE + + Q
Sbjct: 1614 LAVASK--------KKME--------IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 781 QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDL 840
Q+E+ + ++E A S+K+L +E + L+++ ++ ++ ++ E +L +++
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEI 1717
Query: 841 K-----KLNMLMNKNRCSS------EELEQNNRVTENEFVRSLKASERETIKMQDKLNQL 889
K +L K R + EELE+ E + L R+T D LN
Sbjct: 1718 TNSASGKSALLDEKRRLEARIAQLEEELEE-----EQSNMELLNDRFRKTTLQVDTLNAE 1772
Query: 890 SEEKATLLNQLVEAEHQIMLWEKKIQL-AKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLG 948
+ + + A Q+ K+++ +E+ +V S+ T I A++ +I +++ +L
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT-ISALEAKIGQLEEQLE 1831
Query: 949 QLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLE-LRRKIRDVRK 1007
Q K++ + + + + + Q E +R+ D + +Q+E +++ +++
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQVEDERR-------HADQYKEQMEKANARMKQLKR 1884
Query: 1008 ATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGAL 1057
+E + ++R + L + E + + TL+ L R G +
Sbjct: 1885 QLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPI 1934
Score = 68.9 bits (167), Expect = 3e-11
Identities = 114/637 (17%), Positives = 255/637 (40%), Gaps = 62/637 (9%)
Query: 301 RQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERR 360
RQ+E+ K LQE ++ R+ L + +Q L +K ++ D + S E
Sbjct: 1339 RQLEEEKNSLQE---QQEEEEEARKNLEKQVLALQSQLADTKKKVDD--DLGTIESLEEA 1393
Query: 361 QKE--EELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVM 418
+K+ ++ +A + A ++ K LQ E+++L + L + + + ++ +
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF 1453
Query: 419 TQVVKKAET-------ERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDT 471
Q++ + ++ ER RAE E ++++ L ++ E FE Q D
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 472 RILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTD 531
L + + + + KR + QQ ++ ++ +A +A + ++
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573
Query: 532 GEIEAYKKSIMKEEEKNEKLASILNRT--ETEATLLQKLTTQCLTKQVALQSQFNTYRLT 589
+ E + + +E+NE+ +L + E EA L + + L VA + +
Sbjct: 1574 AQFE---RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALA--VASKKKMEIDLKD 1628
Query: 590 LQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKT------------------DAA 631
L+ +A ++ + E + +LQA + Q ELE R + +A
Sbjct: 1629 LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Query: 632 IREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAH 691
I + +E +S + ++ Q L E TN + S + + + I L+
Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 692 QKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFL---NKQLERMVSELGGE- 747
Q + L+ +K + +E++ ++ L NK+L+ + EL G
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 748 ------EVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDAS 801
+ LE +I +L + +++ + A R ++++ ++ + E++ D
Sbjct: 1809 KSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQY 1868
Query: 802 KKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNN 861
K+++ + ++++Q K++ +E E + +KL ++ ++E L +
Sbjct: 1869 KEQME-------KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921
Query: 862 RVTENEFVR------SLKASERETIKMQDKLNQLSEE 892
+N R S S R + ++ +LS++
Sbjct: 1922 STLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDD 1958
Score = 54.7 bits (130), Expect = 5e-07
Identities = 75/433 (17%), Positives = 183/433 (42%), Gaps = 54/433 (12%)
Query: 215 SDLEEFVSQEPVIPPGVPDAHPREGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDE 274
+D+E+ +S + + V H E + Q+++ T+ + + +++ + +
Sbjct: 1511 ADMEDLMSSKDDVGKNV---HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 275 GSQLVVLDPDHPLMVRFQA--ALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLY 332
Q + + L R + K L +Q+ +L+ +L++ + A ++++ ++L
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK 1627
Query: 333 EVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT 392
+++ + K ++ + ++ + + EL+ ARA + A + E KKL +L+
Sbjct: 1628 DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA 1687
Query: 393 EMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRA-- 450
E+ L L A +ER R E+++ +L D++T A
Sbjct: 1688 EILQLQEEL-----------------------ASSERARRHAEQERDEL-ADEITNSASG 1723
Query: 451 --------QQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVE---KRRIMQQW 499
++LE IA E + + + +L + ++D ++ E +R Q+
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKS 1783
Query: 500 ASSLVGMKHRDEAHRAVLEALRGC-QHQAKSTDGEIEAYKKSIMK--EEEKNEKLAS--I 554
++ ++ +++ +A L+ L G + + K+T +EA + + E+E E+ A+ +
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843
Query: 555 LNRTETEATLL-------QKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMIL 607
+ RTE + + ++ Q + ++ + L++ E+ ++ + L
Sbjct: 1844 VRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Query: 608 TEELQAIRQAIQG 620
EL +A +G
Sbjct: 1904 QRELDDATEANEG 1916
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 110 bits (274), Expect = 1e-23
Identities = 169/856 (19%), Positives = 362/856 (42%), Gaps = 137/856 (16%)
Query: 305 KLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEE 364
KL+ + EL A +Q R R L++++ +L ++ +E + E R+KE
Sbjct: 1038 KLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKEL 1097
Query: 365 ELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKK 424
EL + + +K + LQT++++L +K
Sbjct: 1098 ELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLK------------------------EK 1133
Query: 425 AETERI-RAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQY-LAQAEDTRI--LRKAVSE 480
E ER RA++E+++ DL D L ++LEE AQ + + ++T+ L + + E
Sbjct: 1134 LEAERTTRAKMERERADLTQD-LADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEE 1192
Query: 481 ACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKS 540
A + S ++ + A SL ++ + E + V + L + + ++ +
Sbjct: 1193 ATLHFETTSASLKK---RHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQ 1249
Query: 541 IMKEEEKNEKLASILNRTETEATL----LQKLTTQCLTKQVALQSQFNTYRLTLQDTEDA 596
+ + + EKL ++ EAT + +L ++ L S+ + L++ E
Sbjct: 1250 MTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEAL 1309
Query: 597 LSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRL 656
++Q E+ T +++ +R G+LE K+ +A+ LQ+ + + +
Sbjct: 1310 INQLSREKSNFTRQIEDLR----GQLEKETKSQSALAHALQK---AQRDCDLLREQYEEE 1362
Query: 657 QKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEI 716
Q+ K + LSK+N ++ Q + ++ +++ +D++ +++ E+
Sbjct: 1363 QEVKAELHRTLSKVNAEMVQWRMK----------YENNVIQRTEDLE-------DAKKEL 1405
Query: 717 SRRTILIERKQGLINFLNKQLERMVSELG---GEEVGPLELEIKRLSKLIDEHDGKAVQA 773
+ R G+ N N LER +L G+ + L +++ + +D+ ++ +A
Sbjct: 1406 AIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLG-KVRSAAARLDQKQLQSGKA 1464
Query: 774 QVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHM 833
W Q+ EE A LDAS+KE+ + + L++++ E+ Q+ +
Sbjct: 1465 LADW----------KQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRREN 1514
Query: 834 KDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENE-------FVRSLKASERETIKMQDKL 886
K+L ++ L + + + E+E+ ++ E E + A ER K+
Sbjct: 1515 KNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQ 1574
Query: 887 NQLSEEKATLLNQLVEAEHQIMLWEKKIQLA-KEMRSSVDSEIGQTEIRAMKGEIHRMKV 945
+L E KA L +L E + +I + +K Q ++SS+DSE + ++
Sbjct: 1575 LELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEA-------------KSRI 1621
Query: 946 RLGQLLKQQEKMIRAMELAVA---RRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKI 1002
+ +L K+ E+ + MEL ++ R+ + T++ GQ L+ +I
Sbjct: 1622 EVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQ-------------------LQIQI 1662
Query: 1003 RDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNL 1062
+D++ D+ T+ +L+E + + + S++Q++ + L ++L
Sbjct: 1663 KDLQMQLDDSTQLNSDLKE-------QVAVAERRNSLLQSELEDL------------RSL 1703
Query: 1063 SEIVALQTRLKHLQAVKEGRYVFLFRSKQ-SLVLERQRLDKRLALIATILDRVRDEYPQF 1121
E RL + ++ + LF ++ SL+ ++++L+ +A + + V E
Sbjct: 1704 QEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNA 1763
Query: 1122 QEALHKVSQMIANKLE 1137
+E K + AN E
Sbjct: 1764 EEKAKKAAIEAANLSE 1779
Score = 78.6 bits (192), Expect = 3e-14
Identities = 141/675 (20%), Positives = 289/675 (42%), Gaps = 109/675 (16%)
Query: 247 QIQQPSTEEGAMAERVES---------EGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKN 297
Q+++ + + A+A ++ E +EE E + L + MV+++ +N
Sbjct: 1330 QLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYEN 1389
Query: 298 YLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQ-KLLEKSHDRHAMAS 356
+ ++ E L+ +EL + +++ +++ LQ +L + D + S
Sbjct: 1390 NVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRS 1449
Query: 357 SERRQKEEELQAARAL------YTKTCAAANEERKKLAALQTEMENLALHLFYMQNI--- 407
+ R +++LQ+ +AL + ++ A + +K++ AL TE+ L L Y ++I
Sbjct: 1450 AAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTEL--LKLKNTYEESIVGQ 1507
Query: 408 ------DQDMRDDIRVMTQVVKKA-----ETERIRAEIEKKKQDLYVDQLTTRA--QQLE 454
+++++++I +T V++ E E+++ IE++K ++ V T ++ E
Sbjct: 1508 ETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNE 1567
Query: 455 EDIALFEAQYL-AQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAH 513
I F+ + L A+AE L + +SE EI+ +++ + SSL
Sbjct: 1568 SKILHFQLELLEAKAE----LERKLSEKDEEIENFRRKQQCTIDSLQSSL---------- 1613
Query: 514 RAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCL 573
+AKS E+ KK + ++ + E S NR +EAT K Q
Sbjct: 1614 ----------DSEAKSRI-EVTRLKKKMEEDLNEMELQLSCANRQVSEAT---KSLGQLQ 1659
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIR 633
+ LQ Q + D ++ ++ + +L EL+ +R + RR ++ +
Sbjct: 1660 IQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELL 1719
Query: 634 EKLQE-HMTSNKTTKYFNQL------ILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS 686
E + ++ + T +Q + R+QKE ++ + ++ + S
Sbjct: 1720 EATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSE 1779
Query: 687 RLDAHQKTLVELDQDVKKVNELITNSQ---SEISRRTILIERKQGLINFLNKQLERMVSE 743
L Q T+ L++ + + + IT+ Q +E + ++ RKQ ++LE V E
Sbjct: 1780 ELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQ------IQKLESRVRE 1833
Query: 744 LGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKK 803
L GE LE EI+R + +AQ RL++ + ++T + EE KK
Sbjct: 1834 LEGE----LEGEIRR-----------SAEAQRGARRLERCIKELTYQAEE-------DKK 1871
Query: 804 ELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRV 863
L M+ + +++ K++ K++ + E + KK +N E+++ V
Sbjct: 1872 NLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELN-------EVKERAEV 1924
Query: 864 TENEFVRSLKASERE 878
E++ V LK RE
Sbjct: 1925 AESQ-VNKLKIKARE 1938
Score = 76.6 bits (187), Expect = 1e-13
Identities = 177/855 (20%), Positives = 325/855 (38%), Gaps = 166/855 (19%)
Query: 326 ELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERK 385
E+G + +++ LQK LEKS + EEL+A + T+ E+
Sbjct: 856 EVGEEVAGLKEECAQLQKALEKSEFQR-----------EELKAKQVSLTQ------EKND 898
Query: 386 KLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQ 445
+ LQ E E LA N+++ I+ Q+ +A + + +E++++ +
Sbjct: 899 LILQLQAEQETLA-------NVEEQCEWLIKSKIQL--EARVKELSERVEEEEE--INSE 947
Query: 446 LTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVG 505
LT R ++LE++ FE L+K + + T + EKR
Sbjct: 948 LTARGRKLEDEC--FE------------LKKEIDDLETMLVKSEKEKRTT---------- 983
Query: 506 MKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLL 565
+H+ K+ E+E + I K + + +T + +
Sbjct: 984 ------------------EHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHME 1025
Query: 566 QKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELR 625
++ + + L+ Q + + E AL Q++ +M EL ++G L+L
Sbjct: 1026 EEKLSSLSKANLKLEQQ-------VDELEGALEQERKARMNCEREL----HKLEGNLKLN 1074
Query: 626 RKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTS 685
R++ + E Q H+ K + E + M + + G +AQ
Sbjct: 1075 RESMENL-ESSQRHLAEELRKK---------ELELSQMNSKVENEKGLVAQL-------- 1116
Query: 686 SRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELG 745
QKT+ EL +K + E + ++E + R + + L L ER+ E+G
Sbjct: 1117 ------QKTVKELQTQIKDLKEKL---EAERTTRAKMERERADLTQDLADLNERL-EEVG 1166
Query: 746 GEEVGPLELEIK---RLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASK 802
G + LE+ K + KL + + + + T L++ E E Q+ +L K
Sbjct: 1167 GSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVK 1226
Query: 803 KELHIMEQKKLRVE-----SKIEQEKKEQKE-------IEHHMKDLDNDLKKLNMLMNKN 850
++L ++ L++E +++EQ + + E + + L K+ L N
Sbjct: 1227 QKLE-KDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDL 1285
Query: 851 RCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLW 910
+L + EF+R L+ E+E + +NQLS EK+ Q+ + Q+
Sbjct: 1286 AAQKTKLWSES----GEFLRRLE--EKEAL-----INQLSREKSNFTRQIEDLRGQLEK- 1333
Query: 911 EKKIQ------LAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQ-----LLKQQEKMI- 958
E K Q L K R E + +K E+HR ++ +K + +I
Sbjct: 1334 ETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQ 1393
Query: 959 RAMELAVARRETVTTQAEGQRKMD----RKALTRTDFHHKQLELRRKIRD---VRKATDE 1011
R +L A++E E M R A H QLEL + D VR A
Sbjct: 1394 RTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAAR 1453
Query: 1012 CTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTR 1071
+ L+ + + E Q L Q + L +L +L +++ L+
Sbjct: 1454 LDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRE 1513
Query: 1072 LKHLQ--------AVKEGRYVFLFRSKQSLVLERQRLDKRLALIAT--ILDRVRDEYPQF 1121
K+LQ V+EG K ++E ++ + ++ L T L+R + F
Sbjct: 1514 NKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHF 1573
Query: 1122 QEALHKVSQMIANKL 1136
Q L + + KL
Sbjct: 1574 QLELLEAKAELERKL 1588
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 107 bits (266), Expect = 8e-23
Identities = 171/860 (19%), Positives = 365/860 (42%), Gaps = 111/860 (12%)
Query: 304 EKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDR-----HAMASSE 358
+KLK +L E+ + +A+ ++L E +QH + LQ + + H + + +
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 359 RRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVM 418
R KE+ ++ L K A + + KL+ L+ +++ + +Q+ D
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVA-DLQLKLSRLEEQLKEKVTNSTELQH-QLDKTKQQHQE 492
Query: 419 TQVVKKAETERIRAEIEKKKQ--------DLYVDQLTTRAQQLEEDIALFEAQYLAQAED 470
Q ++++ T ++R +Q D + L Q+ +E+I+L E + ED
Sbjct: 493 QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE----KERED 548
Query: 471 TRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKST 530
+A ++ + + + +Q +K++ E+H+ E L Q +
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL---HDQVQEQ 605
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEATLL----QKLTTQCLTKQVALQSQFNTY 586
+ A + ++ E +L S LN ++ + + L + T L+ + A +Q
Sbjct: 606 KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADL 665
Query: 587 RLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTT 646
+ L ++AL Q E +T +L + +Q + E + ++ ++E +++++ + T
Sbjct: 666 QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 647 KYFNQLILRLQKEKTNMMTHLSKINGDIAQ-----TTLDI--THTSSRLDAHQKTLVELD 699
+ I +L+ + + + D+ Q T L++ T S +L+ ++ +
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 700 QDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRL 759
D++K +E + + + +++++ E KQ L + E + E
Sbjct: 786 LDLQKKSEALESIKQKLTKQE---EEKQ----ILKQDFETLSQE---------------- 822
Query: 760 SKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKI 819
+K+ E +Q VT E+ KV E+E + L K +L + +S+
Sbjct: 823 TKIQHEELNNRIQTTVT------ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876
Query: 820 EQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERET 879
E+E ++ K + DL+ K+L + +N + E +SL+ + +
Sbjct: 877 EKENQKGKAA---ILDLEKTCKELKHQLQVQM-------ENTLKEQKELKKSLEKEKEAS 926
Query: 880 IKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAK----EMRSSVDSEIGQTEIRA 935
+++ +LN + E QL++A++ + EK+ Q + E++ S SE + +I A
Sbjct: 927 HQLKLELNSMQE-------QLIQAQNTLKQNEKEEQQLQGNINELKQS--SEQKKKQIEA 977
Query: 936 MKGEIHRMKVRLGQLLK--QQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHH 993
++GE+ ++ +L QQ+ A ELA + + Q ++ + ++DF+
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG 1037
Query: 994 KQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTR 1053
++ EL +D++ ++ + +L + + + Q KL IQ + T +A L +
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN-----QNKL--IQ-ELKTAKATLEQ 1089
Query: 1054 LGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDR 1113
A K Q L E R K LQ +++ + + ++ LV E+ +LA I I R
Sbjct: 1090 DSAKKEQQLQE------RCKALQDIQKEKSL----KEKELVNEK----SKLAEIEEIKCR 1135
Query: 1114 VRDEYPQFQEAL--HKVSQM 1131
E + E L HK+ +
Sbjct: 1136 QEKEITKLNEELKSHKLESI 1155
Score = 100 bits (248), Expect = 1e-20
Identities = 154/829 (18%), Positives = 335/829 (40%), Gaps = 111/829 (13%)
Query: 340 HLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMEN--- 396
H + + + +D S K +++ R A+ EE+ L+ E+E
Sbjct: 59 HYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG 118
Query: 397 LALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEED 456
L + D +++ + Q +++A+TE K+ +DL+ +A QL +
Sbjct: 119 LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI---KQMKDLFEQ----KAAQLATE 171
Query: 457 IALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAV 516
IA +++Y ++ R LR+A + T + ++ ++Q + L+ R
Sbjct: 172 IADIKSKY----DEERSLREAAEQKVTRLTEELNKEATVIQDLKTELL--------QRPG 219
Query: 517 LEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQ 576
+E ++ KK +++ + + + R +KL +C
Sbjct: 220 IE--------------DVAVLKKELVQVQTLMDNMTLERERES------EKLKDECKK-- 257
Query: 577 VALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKL 636
LQSQ+ + T+ L++ E + +ELQ ++ ++ EL +K L
Sbjct: 258 --LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVN---ELTQKNQTLTENLL 312
Query: 637 QEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLV 696
++ K L+++ I + Q LD SRL A + +L
Sbjct: 313 KKEQDYTK-----------LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH 361
Query: 697 ELDQDVKKVNELITNSQSEISR-----RTILIERKQ-----------GL-----INFLNK 735
+ ++ + E + E+S + + E KQ GL IN L+
Sbjct: 362 RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS 421
Query: 736 QLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQL 795
+L +L GE G L+ + + S+ + + + + Q+ RL++++ + E
Sbjct: 422 KLLETERQL-GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 796 ASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSE 855
LD +K++ + + +K+ + + + +++ + D D ++ L L+ K++ +
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 856 ELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQ 915
LE+ + ++A E ET LNQL E+ TL Q+ + ++ + +
Sbjct: 541 LLEKE----REDLYAKIQAGEGETA----VLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
Query: 916 LAKE-MRSSVDSEIGQTEIRAMKGEIHRMKVRLGQL---LKQQEKMIRAMELAVARRETV 971
A+E + V + + +RA + + ++ + +L L + ++ + +++ + + +
Sbjct: 593 QAQENLHDQVQEQ--KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTEL 650
Query: 972 TTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVS---S 1028
AE + R L + Q L+ K +++ K T + + +L++ Q + S S
Sbjct: 651 LLSAEAAKTAQRADL-QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 1029 SLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFR 1088
L E +EK ++ + LE G +K+ + ++ + LQ +++ R +
Sbjct: 710 HLKEYKEKYLSLEQKTEELE------GQIKKLEADSLEVKASKEQALQDLQQQRQL---- 759
Query: 1089 SKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLE 1137
L L L K+L + I+ R + + EAL + Q + + E
Sbjct: 760 -NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
Score = 98.6 bits (244), Expect = 3e-20
Identities = 158/804 (19%), Positives = 339/804 (42%), Gaps = 120/804 (14%)
Query: 246 DQIQQPSTEEGAMAERV--------ESEGSDEEAEDEGSQL-VVLDPDHPLMVRFQAA-- 294
DQ+Q+ A +RV E E++++ SQL + + L++ +AA
Sbjct: 600 DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 295 -----LKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSH 349
L+N+L+ L+ QEL T Q ++ L + Q+H L+ L++
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKIT----TQLDQVTAKLQDKQEHCSQLESHLKEYK 715
Query: 350 DRHAMASSERRQKEEELQAARALYTKTCAA---ANEERKKLAALQTEMENLALHLFYMQN 406
+++ + + E +++ A + A+ A ++ ++ L T++E A L
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLE 775
Query: 407 IDQDMRDDIRVMTQVVKKAET-ERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYL 465
+++++ R+ Q KK+E E I+ ++ K++++ Q L++D +
Sbjct: 776 MEKEIVSSTRLDLQ--KKSEALESIKQKLTKQEEE---------KQILKQDFETLSQETK 824
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWAS----------SLVGMKHRDEAHR- 514
Q E+ L + TE+ + +EK +M + ++ SL K E
Sbjct: 825 IQHEE---LNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 515 ----AVLEALRGC-------QHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEAT 563
A+L+ + C Q Q ++T E + KKS+ KE+E + +L LN + +
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
Query: 564 LLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELE 623
Q Q ++ LQ N E S +Q ++ I +A+QGEL+
Sbjct: 942 QAQNTLKQNEKEEQQLQGNIN---------ELKQSSEQKKKQI---------EALQGELK 983
Query: 624 LRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMM-THLSKINGDIAQTTLDIT 682
+ + KLQ+ +T L +KEK +++ + K Q D
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQE-------LAAEKEKISVLQNNYEKSQETFKQLQSDFY 1036
Query: 683 HTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVS 742
S L A ++ L +++ + E + +++++I + LI+ + L + +
Sbjct: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQ 1096
Query: 743 ELGG--EEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQE----EQLA 796
+L + + ++ E K + K + + R ++E+ K+ +E + E +
Sbjct: 1097 QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1156
Query: 797 SLDASKKELHIMEQKKLRVESK-------IEQEKKEQKEIEHHMKDLDNDLKKLNMLMNK 849
+ K ++ Q+KL ++ K +EQEK+ Q+ ++ +K + +LKK
Sbjct: 1157 EITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKK------- 1209
Query: 850 NRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIML 909
+E + ++ + E E +K E K+ ++ L+E T+ + ++ ++
Sbjct: 1210 -EFIEKEAKLHSEIKEKEV--GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
Query: 910 WEKKIQLAKEMRSSVDSEI--GQTEIRAM-------KGEIHRMKVRLGQLLKQQEKMIRA 960
EK+ + + +++ + Q E RA+ +GEI +++ ++ +L ++ + A
Sbjct: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAA 1326
Query: 961 MELAVARRETVTTQAEGQRKMDRK 984
++ RE + Q + + ++RK
Sbjct: 1327 VQ--ELGRENQSLQIKHTQALNRK 1348
Score = 97.4 bits (241), Expect = 7e-20
Identities = 145/835 (17%), Positives = 350/835 (41%), Gaps = 114/835 (13%)
Query: 345 LEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYM 404
L+ S S E +++ E+ Q + K + +L +L+ ++E F +
Sbjct: 95 LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI 154
Query: 405 QNI----DQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALF 460
+ + +Q + + K + ER E ++K ++L A +++
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQD----L 210
Query: 461 EAQYLAQA--EDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLE 518
+ + L + ED +L+K + + T +D +++E+ R ++ ++ + + A +
Sbjct: 211 KTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATIS 270
Query: 519 ALR-----GCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCL 573
LR G Q A E++ K S+ + +KN+ L L + E + T L++
Sbjct: 271 QLRSELAKGPQEVAVYVQ-ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE------ 323
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQG-ELELRRKTDAAI 632
+ N ++ ++ + L Q L+ L L A ++ +EL K +A
Sbjct: 324 --------KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT- 374
Query: 633 REKLQEHMTSNKTT-KYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAH 691
+KL+E ++ +T ++ +LQ+++ H ++ +I Q + T +L
Sbjct: 375 -QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 692 QKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGP 751
L E Q ++S ++ + +Q + L +L R+ +L +
Sbjct: 434 HGRLKE---------------QRQLSSEKLMDKEQQ--VADLQLKLSRLEEQLKEKVTNS 476
Query: 752 LELEIKRLSKLIDEHDGKAVQAQVTWLRLQQ------EMVKVTQEQEEQLASLDA----S 801
EL+ +L K +H + Q T +L++ ++++ ++++++ +L+A S
Sbjct: 477 TELQ-HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 802 KKELHIMEQKKLRVESKIEQEKKEQ---KEIEHHMKDLDNDLKKLNMLMNKNRCSSEELE 858
K+ + ++E+++ + +KI+ + E +++ L + +L + S ++ +
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 859 QNNRVTENEFVRSLKASERETIKMQDKLNQL------SEEKATLLNQLVEAEHQIMLWEK 912
+N E L+A++ + ++ +N+L S+EK + L+ ++A+ +++L +
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Query: 913 KIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLL-KQQEKMIRAMELAVARRE-- 969
+ A+ + Q ++ + E++++ +L Q+ K Q+K +L +E
Sbjct: 656 AAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK 715
Query: 970 -------TVTTQAEGQRK-------------------MDRKALTRTDFHHKQLELRRKIR 1003
T + EGQ K + ++ TD + EL +++
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLE 775
Query: 1004 DVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLS 1063
++ + + E ++ L +++E+ +++ DF+TL + ++ + L+
Sbjct: 776 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET----KIQHEELN 831
Query: 1064 EIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEY 1118
+QT + LQ VK K++L+ E + +L+ ++ L + E+
Sbjct: 832 N--RIQTTVTELQKVK--------MEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 105 bits (263), Expect = 2e-22
Identities = 187/874 (21%), Positives = 365/874 (41%), Gaps = 143/874 (16%)
Query: 332 YEVQQHLVH-LQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAAL 390
YE Q L+ L+K L S SERR EE+LQ R A + ++++ L
Sbjct: 542 YEASQDLLGTLRKQLSDSE-------SERRALEEQLQRLRDKTDGAMQAHEDAQREVQRL 594
Query: 391 QTEMENLAL---HLFYMQNIDQDMRDDIRVMTQVVKKAETE--RIRAEIEKKKQDLYVDQ 445
++ E L+ +L + + Q +++R + ++ A+ E R R +E++++D D
Sbjct: 595 RSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDG 654
Query: 446 LTTRAQ--QLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSL 503
R + + + E + A++ +R+A+S A + D + EK + + +
Sbjct: 655 ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKA- 713
Query: 504 VGMKHRDEAHRAVLEA----LRGCQHQAKSTDGEIEAYKKSIMKE-----------EEKN 548
EA R LE LR + + + ++ A +S+ ++ EE+
Sbjct: 714 -------EAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEK 766
Query: 549 EKLASILNRTETEATLL----QKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD---- 600
L + E EAT+ ++L L ++VA Q + R+ Q ++AL Q
Sbjct: 767 SALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQ-AQEALEQQLPTL 825
Query: 601 -----QLEQMI--LTEELQAIRQAI-QGELELRRKTDAAIREKLQEHMTSNKTTKYFNQL 652
QL++ + L+ +L Q + Q E +R+ +A R ++ + + QL
Sbjct: 826 RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL 885
Query: 653 ILR------LQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVN 706
+ L +E T + + G + ++ ++L+A ++ L Q +
Sbjct: 886 VAAEREGRTLSEEATRLRLEKEALEGSL----FEVQRQLAQLEARREQLEAEGQALLLAK 941
Query: 707 ELITNSQSEISRRTILIERKQGLINFLNKQ----LERMVSELGGEEVGPLELEIKRLSKL 762
E +T + + ++ I + K L L Q ER E+ E +++RL +
Sbjct: 942 ETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQR- 1000
Query: 763 IDEHDGKAVQAQVTWLRLQQEMVKVT----QEQEEQLASLDASKKELH----IMEQKK-- 812
+ + W L+ E ++ +EQEE LA L+A K+EL ++Q++
Sbjct: 1001 ---------EKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE 1051
Query: 813 --LRVESKIEQ----EKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTEN 866
L ES+ +Q ++ E+ + + + L +++ M + + ++ ++ +R T N
Sbjct: 1052 GLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVN 1111
Query: 867 EFVRSLK-----------ASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEK--- 912
L+ A +E ++Q++ L +++ + L + E Q+ L E
Sbjct: 1112 ALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARD 1171
Query: 913 --KIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRET 970
+ +L + R +S+ G+ R GE+ R LG+ K++E + R+ E +
Sbjct: 1172 GLRRELLEAQRKLRESQEGREVQRQEAGELRR---SLGEGAKEREALRRSNE----ELRS 1224
Query: 971 VTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSL 1030
+AE +R + A + +K+ + +A K EL + V S
Sbjct: 1225 AVKKAESERISLKLA---------NEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSR 1275
Query: 1031 LEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLK-HLQAVKEGRYVFLFRS 1089
LE + +L ++ L+++ TRLG E+ LQ RL +A KE R
Sbjct: 1276 LEARRELQELRRQMKMLDSENTRLG-------RELAELQGRLALGERAEKESR------- 1321
Query: 1090 KQSLVLERQRLDKRLALIATILDRVRDEYPQFQE 1123
+++L L RQRL K A + + ++ + QE
Sbjct: 1322 RETLGL-RQRLLKGEASLEVMRQELQVAQRKLQE 1354
Score = 85.5 bits (210), Expect = 3e-16
Identities = 186/949 (19%), Positives = 371/949 (39%), Gaps = 165/949 (17%)
Query: 299 LNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKL----LEKSHDRHAM 354
L + + L+ +L + QSRA+R EL + V + L +L LE R +
Sbjct: 79 LQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLV 138
Query: 355 ASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLAL-HLFYMQNIDQDMRD 413
S +++ LQ +A Y + A E +++ A L ++ L + ++Q + +
Sbjct: 139 RQSVELRRQ--LQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLE 196
Query: 414 DIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRI 473
+ E E+ R + QDL + +LEE+ + + + A+ +
Sbjct: 197 ---------RSGELEQQRLRDTEHSQDL-----ESALIRLEEE----QQRSASLAQVNAM 238
Query: 474 LRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKS---- 529
LR+ + +A + A+S + R++ W ++HR+ A R E+ S
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLL 298
Query: 530 TDGEIEAYKKSIMKEEEKNEK----LASILNRT-----------ETEATLLQKLTTQCLT 574
++ +++ + + + E+ L L RT T L + L
Sbjct: 299 LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE 358
Query: 575 KQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIRE 634
KQ LQ+Q E L+Q Q++ + +L A EL ++
Sbjct: 359 KQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSA------RVTELGLAVKRLEKQ 412
Query: 635 KLQEHMTSNKTTKYFNQL-ILRLQKE---KTNMMTHLSKINGDIAQTTLDITHTSSRLDA 690
L++ + T+ L LRLQ++ +T L + D+AQ L + + +L
Sbjct: 413 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSG 472
Query: 691 HQKTLVELDQDVKKVNELITNS------------------------------QSEISRRT 720
++T + ++ ++ T S S + +R
Sbjct: 473 SERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532
Query: 721 ILI-------ERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDG----- 768
+ + E Q L+ L KQL SE E ++L +L D+ DG
Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALE--------EQLQRLRDKTDGAMQAH 584
Query: 769 KAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKE 828
+ Q +V LR E+ +++E+ SL ++++ + Q++ ++++ E+ ++++
Sbjct: 585 EDAQREVQRLRSANEL--LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDR 642
Query: 829 IEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQ 888
+E +D D ++ + ++ E+LE V E V +A R T++ +
Sbjct: 643 LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQR----DM 698
Query: 889 LSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLG 948
L EKA + L +AE + E ++ + K + +++ A+ + + K+ L
Sbjct: 699 LQAEKAEVAEALTKAEAGRV--ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
Query: 949 QLLKQQEKMIRAM---------ELAVARRE--------------------TVTTQAEGQR 979
+L+ Q E+ A+ E VAR E ++ + Q
Sbjct: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
Query: 980 KMDRKALT----RTDFHHKQLELRRKI----RDVRKATDECTKTVLELEETQRNVSSSLL 1031
++++ T R+ + +L R++ +++ +A E + V LE R +L
Sbjct: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE-KEALA 875
Query: 1032 EKQEKLSV----IQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLF 1087
++ L+V + + TL + TRL K + +Q +L L+A +E L
Sbjct: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ----LE 931
Query: 1088 RSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKL 1136
Q+L+L ++ L LA +R + QE +++A KL
Sbjct: 932 AEGQALLLAKETLTGELA-------GLRQQIIATQEKASLDKELMAQKL 973
Score = 80.5 bits (197), Expect = 8e-15
Identities = 106/547 (19%), Positives = 222/547 (40%), Gaps = 80/547 (14%)
Query: 411 MRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAED 470
+R +R Q ++ A+ ER D+L T+ L +A EA+ +
Sbjct: 1507 VRGALREFLQELRSAQRER--------------DELRTQTSALNRQLAEMEAERDSATSR 1552
Query: 471 TRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKST 530
R L+KAV+E+ ++ + + A ++ + RA L+ + + ++T
Sbjct: 1553 ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQAT 1612
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTL 590
+ E+ A ++ I K + KL R + + T + ++ +L+ + RL L
Sbjct: 1613 ESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGL 1672
Query: 591 QDTE---DALSQ--DQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKT 645
D E AL D L++ + E++A G L+L T
Sbjct: 1673 SDREAQAQALQDRVDSLQRQVADSEVKA------GTLQL--------------------T 1706
Query: 646 TKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKV 705
+ N + ++++ + + + + +AQ++ + T + QK L + D + +
Sbjct: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL 1766
Query: 706 NELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDE 765
E + + +R+ + RKQ + L V L GE +LE++R+ E
Sbjct: 1767 QERL-----DAARQALSEARKQ------SSSLGEQVQTLRGEVA---DLELQRV-----E 1807
Query: 766 HDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKK---ELHIMEQKKLRVESKIEQE 822
+G+ LQQ + Q QE + A+L+ +K E +++++ ++ + Q
Sbjct: 1808 AEGQ----------LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
Query: 823 KKEQKEIEHHMKDLDNDLKKLNMLMNK---NRCSSEELEQNNRVTENEFVRSLKASERET 879
+ E++E+E L+ D L ++K + S E + R+L +E E
Sbjct: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
Query: 880 IKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGE 939
+ Q ++ QL + L A+ ++ +++++L +E+ ++ +
Sbjct: 1918 AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARER 1977
Query: 940 IHRMKVR 946
HR +VR
Sbjct: 1978 AHRQRVR 1984
Score = 74.3 bits (181), Expect = 6e-13
Identities = 147/814 (18%), Positives = 319/814 (39%), Gaps = 48/814 (5%)
Query: 263 ESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRA 322
E + ++AE E L + + D + + + ++ +L+ LQE+ + ++R
Sbjct: 1221 ELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARR 1280
Query: 323 QRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANE 382
+ QEL + + L + L + R A+ ++ E R K A+
Sbjct: 1281 ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV 1340
Query: 383 ERKKLAALQTEME----NLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKK 438
R++L Q +++ + ++ R + + E + A E +
Sbjct: 1341 MRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAE 1400
Query: 439 QDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQ 498
L + RAQ LE ++A E Q A LR A+ A S R +
Sbjct: 1401 LGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460
Query: 499 WASSLVGMKHRDEAHR-AVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNR 557
A + + + LE G Q + G + + E L L
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQ---PPSPGPATSPASPDLDPEAVRGALREFLQE 1517
Query: 558 TETEATLLQKLTTQ--CLTKQVA-LQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAI 614
+ +L TQ L +Q+A ++++ ++ + + A+++ + + + L +
Sbjct: 1518 LRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
Query: 615 RQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDI 674
+ + + E R+++ R L + T ++ + + Q++ + M + +K+ GD
Sbjct: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
Query: 675 AQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLN 734
+ LDA + V+L+ + + + S+ +S R + Q ++ L
Sbjct: 1638 RR-------LKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQ 1690
Query: 735 KQLERMVSELGGEEVGPLELEIKRLS---KLIDEHDGKAVQAQVTWL--RLQQEMVKVTQ 789
+Q+ SE+ + G L+L ++RL+ ++E +G A++ +V L L Q +
Sbjct: 1691 RQVAD--SEV---KAGTLQLTVERLNGALAKVEESEG-ALRDKVRGLTEALAQSSASLNS 1744
Query: 790 EQEEQL---ASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNML 846
+++ L +L A + + +++++ + + +K+ + ++ L ++ L +
Sbjct: 1745 TRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL- 1803
Query: 847 MNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQ 906
R +E Q R + A+ K+QD+ L E +L L + E +
Sbjct: 1804 ---QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE 1860
Query: 907 IMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVA 966
E+ ++ R ++ + + E ++ H VRL + ++ + EL +A
Sbjct: 1861 KREVERSALRLEKDRVALRRTLDKVEREKLRS--HEDTVRLSAEKGRLDRTLTGAELELA 1918
Query: 967 RRETVTTQAEGQ----RKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEET 1022
+ Q E Q + A D +QLEL++++ +R A + +T+ E
Sbjct: 1919 EAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERA 1978
Query: 1023 QRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGA 1056
R L +E++S ++ L+ +L R A
Sbjct: 1979 HRQRVRGL---EEQVSTLKGQ---LQQELRRSSA 2006
Score = 56.6 bits (135), Expect = 1e-07
Identities = 169/916 (18%), Positives = 361/916 (39%), Gaps = 85/916 (9%)
Query: 265 EGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLD----LQELVVATKQS 320
E E+ E EG L++ + A L+ + EK LD Q+LV A +++
Sbjct: 924 EARREQLEAEGQALLLAKET---LTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREA 980
Query: 321 RAQRQELGVNLYEVQQHLVHLQKLL--EKSHDRHAMASSERRQKEE---ELQAARALYTK 375
+A +E E Q L ++ E +R + S +R++EE L+A + ++
Sbjct: 981 QASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSE 1040
Query: 376 TCAAANEERKK--LAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAE 433
AA +ER + L A + + L+L + + + + + + E ++ A+
Sbjct: 1041 EIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQ 1100
Query: 434 IEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKR 493
+++ V+ LT+ + L A E A A++ R L++ + + D+ E
Sbjct: 1101 SRQEQDRSTVNALTSELRDLR---AQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAE 1157
Query: 494 RIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLAS 553
+ Q + RD R +LEA R + + + ++ +E E L
Sbjct: 1158 ELRTQLR---LLEDARDGLRRELLEAQRKLRESQEGRE----------VQRQEAGE-LRR 1203
Query: 554 ILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQA 613
L E L++ + + +S+ + +L +D E L+ + + + +E
Sbjct: 1204 SLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGE 1263
Query: 614 IRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGD 673
+R +Q E+E R + +A R +LQE + K + RL +E + L+
Sbjct: 1264 LRTGLQ-EVE-RSRLEA--RRELQE---LRRQMKMLDSENTRLGRELAELQGRLALGERA 1316
Query: 674 IAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFL 733
++ + RL + +L + Q+++ + + E RT R++ L+ L
Sbjct: 1317 EKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEF--RT----RERRLLGSL 1370
Query: 734 NKQLERMVSELGGEEVGPLELEIKR-----LSKLIDEHDGKAVQAQVTWLRLQQEMVKVT 788
+ +L L+LE R L + +G+A + R++ +
Sbjct: 1371 EEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR---- 1426
Query: 789 QEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMN 848
+ E QL L ++ + + + + E + L N L
Sbjct: 1427 RAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGL-NSPSTLECSPG 1485
Query: 849 KNRCS--------SEELEQNN-RVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQ 899
S S +L+ R EF++ L++++RE +++ + + L+ + A + +
Sbjct: 1486 SQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAE 1545
Query: 900 LVEAEHQIMLWEKKIQLAKEMRSSVDSEIG--QTEIRAMKGEIHRMK----------VRL 947
A + +K + ++E R SVD + Q E+ + + R + L
Sbjct: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL 1605
Query: 948 GQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRK-----I 1002
+ L+ E +RA + +++ + T+ EG ++ ++ L ++ +LEL+R+ +
Sbjct: 1606 ERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGEL 1665
Query: 1003 RDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRL----GALK 1058
+ R + L++ ++ + + + K +Q + L L ++ GAL+
Sbjct: 1666 QRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR 1725
Query: 1059 RQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEY 1118
+ AL L + ++ + + L ++ + +RQ L +RL L R +
Sbjct: 1726 DKVRGLTEALAQSSASLNSTRD-KNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
Query: 1119 PQFQEALHKVSQMIAN 1134
E + + +A+
Sbjct: 1785 SSLGEQVQTLRGEVAD 1800
Score = 37.7 bits (86), Expect = 0.063
Identities = 67/278 (24%), Positives = 116/278 (41%), Gaps = 65/278 (23%)
Query: 770 AVQAQVTWL-RLQQEMVKVTQEQEE--------QLASLDASKKELHIMEQKKLRVESKIE 820
A AQ+T L L +E+V Q E ++ASL + ++E +++Q+ RVE +
Sbjct: 39 AQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLA 98
Query: 821 QEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETI 880
Q + E+ E L K SE LEQ R L+ E ET
Sbjct: 99 QSRAERDE-----------------LAIKYNAVSERLEQALR---------LEPGELET- 131
Query: 881 KMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTE-IRAMKGE 939
+E L+ Q VE Q L E++ +++++ + + Q + ++ ++G+
Sbjct: 132 ----------QEPRGLVRQSVELRRQ--LQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK 179
Query: 940 IHRMKVRLGQLLKQQEKMIRAMELAVAR-RET----------VTTQAEGQRKMDR---KA 985
I + K R +L +Q+ + R+ EL R R+T + + E QR A
Sbjct: 180 ILQYKKRCSEL--EQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNA 237
Query: 986 LTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQ 1023
+ R + D+RK T++ T+ ELE +
Sbjct: 238 MLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHRE 275
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 105 bits (261), Expect = 3e-22
Identities = 181/929 (19%), Positives = 377/929 (40%), Gaps = 121/929 (13%)
Query: 216 DLEEFVSQEPVIPPGVPDAHPR-EGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDE 274
DLE + QE + + A + EGDL + Q+ I ++ + E+++ + D ++
Sbjct: 1035 DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNS 1094
Query: 275 GSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEV 334
++ + L ++ Q LK R IE+L+ +L+ A + R +L L E+
Sbjct: 1095 K-----IEDEQVLALQLQKKLKENQAR-IEELEEELEAERTARAKVEKLRSDLSRELEEI 1148
Query: 335 QQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERK-KLAALQTE 393
+ L + + +E ++ +L+ A + T AA ++ +A L +
Sbjct: 1149 SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1208
Query: 394 MENLALHLFYMQNIDQDMR---DDIRV-MTQVVK-KAETERIRAEIEKKKQDLYVDQLTT 448
++NL ++ + + DD+ M Q++K KA E++ +E + + V
Sbjct: 1209 IDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV----- 1263
Query: 449 RAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKH 508
+ ++ + + F Q + L + + E I ++ K QQ ++
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Query: 509 RDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETE-ATLLQK 567
+A A+ AL+ +H + + ++ +E E +L +L++ +E A K
Sbjct: 1324 EGKAKNALAHALQSARH-------DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1376
Query: 568 LTTQCLTKQVALQSQFNTYRLTLQDTEDALS----------------QDQLEQMIL-TEE 610
T + + L+ LQD E+A+ Q+++E +++ E
Sbjct: 1377 YETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1436
Query: 611 LQAIRQAIQGELELRRKTDAAIREKLQEHMT----SNKTTKYFNQLILRLQKEKTNMMTH 666
A A+ + K A ++K +E + S K + + + +L+ + H
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496
Query: 667 LSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERK 726
L + +I+ + +L K + EL++ K++ QS + +E +
Sbjct: 1497 LETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE 1556
Query: 727 QGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLR----LQQ 782
+G I L QLE ++ EI+R + E D + QA+ R LQ
Sbjct: 1557 EGKI--LRAQLE----------FNQIKAEIERK---LAEKDEEMEQAKRNHQRVVDSLQT 1601
Query: 783 EMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDL------ 836
+ T+ + E L + +L+ ME + + +K+ K ++ +KD
Sbjct: 1602 SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1661
Query: 837 ----DNDLKK-LNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSE 891
++DLK+ + ++ +N ELE+ V E + RS K +E+E I+ +++ L
Sbjct: 1662 AVRANDDLKENIAIVERRNNLLQAELEELRAVVE-QTERSRKLAEQELIETSERVQLLHS 1720
Query: 892 EKATLLNQLVEAEHQIMLWEKKIQLA---------KEMRSSVDSEIGQTEIRA---MKGE 939
+ +L+NQ + E + + +++ A K ++ D+ + E++
Sbjct: 1721 QNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1780
Query: 940 IHRMKVRLGQLLKQ-QEKMIRAMELA-------VARRETVTTQAEGQRKMDRKALTRTDF 991
+ RMK + Q +K Q ++ A ++A + + E + EG+ + ++K +
Sbjct: 1781 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVK 1840
Query: 992 HHKQLELRRKIRDVRKATDECTKTVLELE--------------------ETQRNVSSSLL 1031
++ E R+I+++ T+E K +L L+ E Q N + S
Sbjct: 1841 GMRKSE--RRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898
Query: 1032 EK-QEKLSVIQADFDTLEADLTRLGALKR 1059
K Q +L + D E+ + +L A R
Sbjct: 1899 RKVQHELDEAEERADIAESQVNKLRAKSR 1927
Score = 86.3 bits (212), Expect = 2e-16
Identities = 152/841 (18%), Positives = 348/841 (41%), Gaps = 121/841 (14%)
Query: 294 ALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHA 353
A K L + +LK D+ +L + + ++ + + + + L +++ K
Sbjct: 940 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Query: 354 MASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRD 413
+Q ++LQ + + +++ L+ +E ++ + +
Sbjct: 1000 ALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEG 1059
Query: 414 DIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTT---------------------RAQQ 452
D+++ + + E ++++ E + KK++ ++Q + R ++
Sbjct: 1060 DLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEE 1119
Query: 453 LEEDIALFEAQYLAQAEDTRILRKAVSEACTEID--------AISVEKRRIMQQWASSLV 504
LEE++ EA+ A+A+ + LR +S EI A SV+ ++ A
Sbjct: 1120 LEEEL---EAERTARAKVEK-LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQK 1175
Query: 505 GMKHRDEA---HRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETE 561
+ +EA H A ALR + + GE + +K++ + EK L +
Sbjct: 1176 MRRDLEEATLQHEATAAALRKKHADSVAELGE-QIDNLQRVKQKLEKEKSEFKLELDDVT 1234
Query: 562 ATLLQKLTTQCLTKQVA--LQSQFNTYRLTLQDTEDALSQDQLEQMILT----------E 609
+ + Q + + ++V+ L+ Q N YR+ L++ + +L+ ++ L E
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE 1294
Query: 610 ELQA-IRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQL-----ILRLQKE---- 659
E +A I Q +G+L ++ + R+ +E N +LR Q E
Sbjct: 1295 EKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETE 1354
Query: 660 -KTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISR 718
K + LSK N ++AQ T DA Q+T EL++ KK+ + + +++ +
Sbjct: 1355 AKAELQRVLSKANSEVAQW-----RTKYETDAIQRT-EELEEAKKKLAQRLQDAEEAVEA 1408
Query: 719 RTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKR--LSKLI-------DEHDGK 769
+ + L ++E ++ ++ L+ K+ K++ +E +
Sbjct: 1409 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE 1468
Query: 770 AVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEI 829
+Q L E+ K+ EE L L+ K+E ++++ + ++ + K E+
Sbjct: 1469 LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL 1528
Query: 830 EHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQL 889
E K L+ E+LE + + E E SL+ E + ++ Q + NQ+
Sbjct: 1529 EKVRKQLE----------------VEKLELQSALEEAE--ASLEHEEGKILRAQLEFNQI 1570
Query: 890 SEEKATLLNQLVEAEHQIMLWEKKIQ-LAKEMRSSVDSEI-GQTEI----RAMKGEIHRM 943
KA + +L E + ++ ++ Q + +++S+D+E + E+ + M+G+++ M
Sbjct: 1571 ---KAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEM 1627
Query: 944 KVRL---GQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRR 1000
+++L ++ + +K +++++ + + Q ++D D + R
Sbjct: 1628 EIQLSHANRMAAEAQKQVKSLQ---------SLLKDTQIQLDDAVRANDDLKENIAIVER 1678
Query: 1001 KIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTL-------EADLTR 1053
+ ++ +E V + E +++ L+E E++ ++ + +L E+DLT+
Sbjct: 1679 RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQ 1738
Query: 1054 L 1054
L
Sbjct: 1739 L 1739
Score = 58.9 bits (141), Expect = 3e-08
Identities = 83/432 (19%), Positives = 187/432 (43%), Gaps = 66/432 (15%)
Query: 747 EEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELH 806
+E+ ++ E R+ + +++ + + + L+++MV + QE+ + + A + L+
Sbjct: 849 KEMATMKEEFGRIKETLEKSEARRKE-------LEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 807 IMEQK-------KLRVESKI-------EQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRC 852
E++ K+++E+K+ E E++ E+ + L+++ +L ++
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 853 SSEELEQNNRVTENEF--------------------VRSLKASERETIK----MQDKLNQ 888
+ ++E+ TEN+ ++L+ + ++ + +DK+N
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 889 LSEEKATLLNQLVEAEHQIMLWEKKIQLAKE-MRSSVDSEIGQTEIRAMKGEIHRMKVRL 947
LS+ K L Q+ + E + EKK+++ E + ++ ++ T+ M ++ K++L
Sbjct: 1022 LSKSKVKLEQQVDDLEGSLE-QEKKVRMDLERAKRKLEGDLKLTQESIM--DLENDKLQL 1078
Query: 948 GQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIR-DVR 1006
+ LK++E I + + + Q + + K ++ R + ++LE R R V
Sbjct: 1079 EEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQ---ARIEELEEELEAERTARAKVE 1135
Query: 1007 KATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIV 1066
K + ++ + E+ E + + E +A+F + DL L+ E
Sbjct: 1136 KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE-ATLQH----EAT 1190
Query: 1067 ALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEA-- 1124
A R KH +V E L +L +Q+L+K + LD V Q +A
Sbjct: 1191 AAALRKKHADSVAE-----LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1245
Query: 1125 -LHKVSQMIANK 1135
L KVS+ + ++
Sbjct: 1246 NLEKVSRTLEDQ 1257
Score = 52.8 bits (125), Expect = 2e-06
Identities = 89/437 (20%), Positives = 189/437 (43%), Gaps = 68/437 (15%)
Query: 726 KQGLINFL----NKQLERMVSELGGEEVGPL-ELEIKRLSKLIDEHDGKAV--------- 771
K GL+ L +++L R+++ + + G L +E K K+++ D V
Sbjct: 768 KAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFK---KIVERRDALLVIQWNIRAFM 824
Query: 772 -QAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIE 830
W++L ++ + + E ++KE+ M+++ R++ +E+ + +KE+E
Sbjct: 825 GVKNWPWMKLYFKIKPLLKSAE--------TEKEMATMKEEFGRIKETLEKSEARRKELE 876
Query: 831 HHMKDL---DNDLK--------KLN--------MLMNKNRCSSEELEQNNRV-TENEFVR 870
M L NDL+ LN ++ NK + ++ E N R+ E E
Sbjct: 877 EKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA 936
Query: 871 SLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQ 930
L A +R K++D+ ++L ++ L L + E + E K++ E + +D I +
Sbjct: 937 ELTAKKR---KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAK 993
Query: 931 -TEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRT 989
T+ + E H+ + L+ +E + ++ + + E EG + ++K R
Sbjct: 994 LTKEKKALQEAHQQAL---DDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKK--VRM 1048
Query: 990 DFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEA 1049
D +RK+ K T E ++++LE + + L +K+ ++ + + +
Sbjct: 1049 DLE----RAKRKLEGDLKLTQE---SIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQV 1101
Query: 1050 DLTRLGALKRQNLSEIVALQTRLKHLQAVKEGR-YVFLFRSKQSLVLER--QRLDKRLAL 1106
+L ++N + I L+ + L+A + R V RS S LE +RL++
Sbjct: 1102 LALQLQKKLKENQARIEELE---EELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1158
Query: 1107 IATILDRVRDEYPQFQE 1123
+ ++ + +FQ+
Sbjct: 1159 TSVQIEMNKKREAEFQK 1175
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 104 bits (259), Expect = 5e-22
Identities = 179/934 (19%), Positives = 377/934 (40%), Gaps = 159/934 (17%)
Query: 238 EGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQ--LVVLDPDHPLMVRFQAAL 295
+GDL + ++Q TE A+ + + + D E + + + +L+ +H ++ +A+L
Sbjct: 273 QGDLE--KAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL 330
Query: 296 KNYLNRQIEKLKL-----DLQELVVATKQSRAQRQ------ELGVNLYEV---------- 334
N Q EKL L D+ +++V + AQ EL +++
Sbjct: 331 SR--NAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKAL 388
Query: 335 ----------QQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEER 384
+Q + L++ L + + + Q EEE +A R K +
Sbjct: 389 TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLA 448
Query: 385 KKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIE-------KK 437
+ LQ E+++L+ +Q +++R + V+ Q + + +++ K+
Sbjct: 449 GQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508
Query: 438 KQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQ 497
+Q + ++L+E + EA+ + LR+A+ + E + + E+ +
Sbjct: 509 EQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTA 568
Query: 498 QWA---SSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYK----KSIMKEEEKNEK 550
A S+ + + + + LR + + + + K + +++ EE+N+
Sbjct: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628
Query: 551 LASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEE 610
+ S + E LQ + ++ AL + LQ E+A ++ Q + + EE
Sbjct: 629 VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688
Query: 611 LQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILR---LQKEKTNMMTHL 667
+ I++ + E R + +AA + Q H + + + + + L +EK + L
Sbjct: 689 KEEIQKKLS---ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRL 745
Query: 668 SKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQ 727
+ D ++ L E Q + EL+ +S E ++ +IE +
Sbjct: 746 QAVERD------------------RQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787
Query: 728 GLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKV 787
G LE++I+ +++ + +Q +V L+L+ + +
Sbjct: 788 G----------------------QLEVQIQTVTQAKE-----VIQGEVRCLKLELDTERS 820
Query: 788 TQEQEEQLASLDASKKELH---IMEQKKLRVESKIEQ-EKKEQKEIEHHMKDLDNDLKKL 843
EQE A+ ++ E +EQ+K E ++ Q +K +KE H ++L L+ L
Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880
Query: 844 NMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEA 903
E++E R+ E + +E E I+ Q + + E A QL
Sbjct: 881 ER---------EKMELEMRLKEQQ-------TEMEAIQAQREEERTQAESALCQMQLETE 924
Query: 904 EHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMEL 963
+ ++ L E +Q KE+ + + + E R +++ +L +Q+ I +L
Sbjct: 925 KERVSLLETLLQTQKELADA-----------SQQLERLRQDMKVQKLKEQETTGILQTQL 973
Query: 964 AVARRETVTTQAEGQRKMDRKALTR--TDFHHKQLELRRKIRDVR--------------- 1006
A+RE +A Q + D AL + +++L++++ D++
Sbjct: 974 QEAQREL--KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031
Query: 1007 ------KATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQ 1060
+ T E + ELE + +++ SL+EK+++L V+Q + +L+ L ++
Sbjct: 1032 EVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQE 1091
Query: 1061 NLSEIVALQTRLKHL-QAVKEGRYVFLFRSKQSL 1093
E L +++ L Q VKE FL + Q L
Sbjct: 1092 AQGEQKELSAQMELLRQEVKEKEADFLAQEAQLL 1125
Score = 95.1 bits (235), Expect = 3e-19
Identities = 198/952 (20%), Positives = 366/952 (38%), Gaps = 166/952 (17%)
Query: 218 EEFVSQEPVIPPGVPDAHPREGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQ 277
E +Q + V +A + + ++ ++ + E VESE +A E +
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGE 1410
Query: 278 LVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQH 337
L V A L + L L E + R Q QEL E+Q+
Sbjct: 1411 LKV-------------AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR-EMQKA 1456
Query: 338 LVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENL 397
+ L L K ++ E+ Q EL+ R++ A E +KL + ++ L
Sbjct: 1457 ALELLSLDLKKRNQEVDLQQEQIQ---ELEKCRSVLEHLPMAVQEREQKLTVQREQIREL 1513
Query: 398 ALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDI 457
+N+ + ++ Q++ E R +++ K+ L L A +LEE+
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKDQMI-----ESQRGQVQDLKKQLVT--LECLALELEENH 1566
Query: 458 ALFEAQY--LAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRA 515
E Q + + E R ++ A T + E+ + +Q +S + H E+H
Sbjct: 1567 HKMECQQKLIKELEGQRETQRV---ALTHLTLDLEERSQELQAQSSQI----HDLESHST 1619
Query: 516 VLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTK 575
VL + + D E+++ ++ I + + + E L L R + E +LQK Q L
Sbjct: 1620 VLA------RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL-MLQKERIQVLED 1672
Query: 576 QVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREK 635
Q Q++ E+ L Q +L EL RQ +Q E + A R
Sbjct: 1673 QRTRQTKI---------LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
Query: 636 LQEHMT-----SNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTS----- 685
L EHM K + + I LQ+ K + L ++ + +T+L ++
Sbjct: 1724 L-EHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVV 1782
Query: 686 --------------------SRLDAHQKTLVELDQDVK--------------KVNELITN 711
S+LD Q+ L + DQ+++ +V E
Sbjct: 1783 LQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADA 1842
Query: 712 SQSEISRRTILIERKQGLINFLNKQLERMVSELG---------GEEVGPLELEIKRLSKL 762
Q + + + ++ + G + +Q R+ EL E +G L E + K
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902
Query: 763 I-----------DEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDA-SKKELHIMEQ 810
+ EH+ + Q +WL+ Q V +E++++L +L A S+ H E
Sbjct: 1903 LLALQQQCAEQAQEHEVETRALQDSWLQAQA----VLKERDQELEALRAESQSSRHQEEA 1958
Query: 811 KKLRVESKIEQ--------EKKEQKEIEHH--MKDLDNDLKKLNMLMNKNRCSSEELEQN 860
+ R E+ E + KEQ +E + L+ L ++ + S +LE+
Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA 2018
Query: 861 NRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKI-QLAKE 919
R+ E E + + ++ Q+ + QL + A +L + + L EK + Q +E
Sbjct: 2019 LRIQEGEI-------QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQE 2071
Query: 920 MRSSVDSEIGQT----EIRAMKGEIHRMKVRLGQ----LLKQQEKMIRAMELAVARRETV 971
+GQ EIR + + +++ L Q +L+ +E R A+
Sbjct: 2072 NMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKT 2131
Query: 972 TTQAEGQRKMD-------------RKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLE 1018
+ E K+D + AL +T+ +++E R K +D+ + + +V
Sbjct: 2132 SPMEEQSLKLDSLEPRLQRELERLQAALRQTEA--REIEWREKAQDLALSLAQTKASVSS 2189
Query: 1019 LEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQT 1070
L+E + +S+LE+ + +Q E +LTR AL+++ L A T
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQD-----ELELTR-RALEKERLHSPGATST 2235
Score = 82.8 bits (203), Expect = 2e-15
Identities = 192/989 (19%), Positives = 380/989 (38%), Gaps = 154/989 (15%)
Query: 260 ERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQEL--VVAT 317
+++E +D EAE + D L + K+ + L+ +L EL +A+
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEE--KSKWEGKQNSLESELMELHETMAS 1324
Query: 318 KQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASS-ERRQK-------EEELQAA 369
QSR +R EL + ++ L+ K + H A+ E R + EE+L+ A
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384
Query: 370 RALYTKTCAAANEERKKLAALQTE-----------MENLALHLFYMQNIDQDMRDDIRVM 418
R+ ER++ ALQ + ENLAL + ++++ +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQI 1444
Query: 419 TQVVKKAETERIRAEI---EKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILR 475
++ K+ E ++ E+ + KK++ VD + Q+LE+ ++ E +L A R +
Sbjct: 1445 QELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLE--HLPMAVQEREQK 1502
Query: 476 KAVS-EACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEI 534
V E E++ +R +++ L+ ++ +D+ ++E+ RG K +
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEH---QLLELEKKDQ----MIESQRGQVQDLKKQLVTL 1555
Query: 535 EAYKKSIMKEEEKNEKLASILN----RTETEATLLQKLTTQCLTKQVALQSQ------FN 584
E + + K E ++ + ET+ L LT + LQ+Q
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615
Query: 585 TYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQ--EHMTS 642
++ L Q+ Q EELQ ++ + +LE R + +E++Q E +
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 643 NKTT---KYFNQLILRLQKEKTNMMTHLSKIN--------------GDIAQTTLDITHTS 685
+T + Q+ L L++ + T + G + L +
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735
Query: 686 SRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELG 745
++ Q+ + EL + ++ + + ++ ++L+ +++ I L +QL+
Sbjct: 1736 KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE------ 1789
Query: 746 GEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKEL 805
E G EL+ + L +DE Q LQQE + ++E DA + L
Sbjct: 1790 AREQG--ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847
Query: 806 HIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTE 865
+++ K++ + +E + ++ L ++ R S E E+ +
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ 1907
Query: 866 NEFVRSLKASERETIKMQDK-------LNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAK 918
+ + E ET +QD L + +E L + + HQ + + +
Sbjct: 1908 QQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQ 1967
Query: 919 E--------------------------------MRSSVD-----SEIGQTEIRAMKGEIH 941
E +++S+D S + +R +GEI
Sbjct: 1968 EALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQ 2027
Query: 942 RMKVR-------LGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHK 994
+R L Q L Q+++ +R + RE + ++ QR + + + +
Sbjct: 2028 DQDLRYQEDVQQLQQALAQRDEELRHQQ----EREQLLEKSLAQRVQENMIQEKQNLGQE 2083
Query: 995 QLE-----LRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQAD---FDT 1046
+ E L + +R+++ + + +LEL ETQ+ + L K S ++ D+
Sbjct: 2084 REEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143
Query: 1047 LE----ADLTRLGALKRQNLSEIVALQTRLKHL--------QAVKEGRYVFLFRSKQSLV 1094
LE +L RL A RQ + + + + + L +V + V +F Q+ V
Sbjct: 2144 LEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF--LQASV 2201
Query: 1095 LER----QRLDKRLALIATILDRVRDEYP 1119
LER QRL L L L++ R P
Sbjct: 2202 LERDSEQQRLQDELELTRRALEKERLHSP 2230
Score = 82.0 bits (201), Expect = 3e-15
Identities = 178/905 (19%), Positives = 355/905 (39%), Gaps = 169/905 (18%)
Query: 326 ELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQ-----KEEELQAARALYTKTCA-- 378
EL +L ++Q+ +QK L +S + A+++ Q K +E ARA+ K
Sbjct: 677 ELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVR 736
Query: 379 ----------AANEERKKLA----ALQTEMENLALHLFYMQ---NIDQDMRDDIRVMTQV 421
A +R+ LA L + E L LF Q ++ + + + V Q
Sbjct: 737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQT 796
Query: 422 VKKA---------------ETERIRAEIEKKKQDLYVDQLTTRAQQ----LEEDIALFEA 462
V +A +TER +AE E+ D QL Q+ LE+ A E
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQER---DAAARQLAQAEQEGKTALEQQKAAHEK 853
Query: 463 -----------------QYLAQA-----EDTRILRKAVSEACTEIDAISVEKRRIMQQWA 500
Q LA+A + L + E TE++AI ++ Q
Sbjct: 854 EVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAE 913
Query: 501 SSLVGMKHRDEAHR-AVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTE 559
S+L M+ E R ++LE L Q + ++E ++ + ++ K ++ IL
Sbjct: 914 SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQL 973
Query: 560 TEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQ 619
EA Q K+ A Q + + LQ+ +L QD+++ L ++++ ++ +
Sbjct: 974 QEA--------QRELKEAARQHRDDL--AALQEESSSLLQDKMD---LQKQVEDLKSQLV 1020
Query: 620 GELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTL 679
+ + +R + ++EKL+E T+ +N++ L++EK ++
Sbjct: 1021 AQDDSQRLVEQEVQEKLRE-------TQEYNRIQKELEREKASL---------------- 1057
Query: 680 DITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLER 739
T S ++ Q+ LV + D + EL Q ++ QG L+ Q+E
Sbjct: 1058 ----TLSLMEKEQRLLVLQEADSIRQQELSALRQD--------MQEAQGEQKELSAQMEL 1105
Query: 740 MVSELGGEEVGPLELEIKRLSKLIDEH-------------DGKAVQAQVTWLRLQQEMVK 786
+ E+ +E L E + L +L H + KA Q Q+ + ++
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165
Query: 787 VTQEQEE-QLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNM 845
+ EQ+ A A L+ Q+ L + E + + L+ D
Sbjct: 1166 LAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARS 1225
Query: 846 LMNK----NRCSSEELEQNNRVTENEFVRSLKASE--RETI-KMQDKLNQLSEEKATLLN 898
L + S+E + + ++ + + R+ + K++++L EK+ +
Sbjct: 1226 LFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHT 1285
Query: 899 QLVEAEHQIMLWEKKIQLAKEMRSSVDSEI-------GQTEIRAMKGEIHRMKVRLGQLL 951
+L + + Q+ +++ + ++S++SE+ + R + E+ RM+ + + L
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345
Query: 952 KQQEK-----MIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVR 1006
Q K + ++ AV + A + R A + ++++E R+
Sbjct: 1346 LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405
Query: 1007 KATDE---------------CTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADL 1051
+ E T+T+ E EE + + E +++ + +A + L DL
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDL 1465
Query: 1052 TRLGA---LKRQNLSEIVALQTRLKHL-QAVKEGRYVFLFRSKQSLVLERQRLDKRLALI 1107
+ L+++ + E+ ++ L+HL AV+E + +Q LE+ R +R L
Sbjct: 1466 KKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLE 1525
Query: 1108 ATILD 1112
+L+
Sbjct: 1526 HQLLE 1530
Score = 73.2 bits (178), Expect = 1e-12
Identities = 163/848 (19%), Positives = 335/848 (39%), Gaps = 117/848 (13%)
Query: 300 NRQIEKLKLDLQELVVATKQSRAQRQELG----VNLYEVQQHLVHLQKLLEKSHDRHAMA 355
N + + L+L L+E V+A +Q A+ Q N E QQ L + L+ ++
Sbjct: 10 NMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSW 69
Query: 356 SSERRQKEEELQAARALYTKTCAAAN---------EERKKLAALQTEMENLALHLFYMQN 406
E ++ E + N EE+++ +L L LH+
Sbjct: 70 CQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADV 129
Query: 407 IDQDMRDDIRVMTQVVKKAETERIRAEIE-KKKQDLYVDQLT---TRAQQLEEDIALFEA 462
+++ +R+D+ +T +A E +R E + + +Q+ + L R L ++ F
Sbjct: 130 VNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR 189
Query: 463 QYL------------AQAEDTRI--------LRKAVSEACTEIDAISVEKRRIMQQWASS 502
+L +AE R+ LR V E + R Q
Sbjct: 190 HFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249
Query: 503 LVGMKHRD-EAHRAVLEAL----RGCQHQAKSTD--GEIEAYKKSIMKEEEKNEKLASIL 555
L + + EAH E + +G +A+ D E+ A K+ E EK+ L
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 556 NRT----ETEATLLQK----LTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD------- 600
T ET T L + L+ ++++LQ + + D ++Q
Sbjct: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
Query: 601 QLEQMILTE-ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKE 659
+L+ I ++ + Q +A+ + + A+++ Q+ + Q + ++E
Sbjct: 370 ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEE 429
Query: 660 KTNMMTHLSKINGD---IAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEI 716
+ L K+ G+ +A T+D+ E+D + K EL+ ++ E+
Sbjct: 430 GKALRQRLQKLTGERDTLAGQTVDLQG-------------EVD-SLSKERELLQKAREEL 475
Query: 717 SRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVT 776
++ ++E++ + +N +L+ G G E + + L + E +
Sbjct: 476 RQQLEVLEQEAWRLRRVNVELQLQ----GDSAQGQKEEQQEELHLAVRERE--------- 522
Query: 777 WLRLQQEMVKVTQEQEEQLA-------SLDASKKELHIMEQKKLRVESKIEQEKKEQKEI 829
RLQ+ ++ + +Q E L+ +L++S E ++ Q++ V + + + ++ E+
Sbjct: 523 --RLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAEL 580
Query: 830 EHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQL 889
L ++ L K +E L ++V N+ + L E E + ++
Sbjct: 581 SSSENTLKTEVADLRAAAVKLSALNEALAL-DKVGLNQQLLQL---EEENQSVCSRMEAA 636
Query: 890 SEEKATLLNQLVEAE-HQIMLWEKKIQLAKEMRSSVDSEIG-QTEIRAMKGEIHRMKVRL 947
+ + L L EAE + LWEK L +++ + ++ Q ++R ++ E ++ +L
Sbjct: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Query: 948 GQLLKQQE---KMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRD 1004
+ QQE + + R+E V +A +++AL R ++ L +++
Sbjct: 697 SESRHQQEAATTQLEQLHQEAKRQEEVLARA----VQEKEALVR-----EKAALEVRLQA 747
Query: 1005 VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSE 1064
V + + + + L + + SSL E Q++ SVI+ LE + + K E
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE 807
Query: 1065 IVALQTRL 1072
+ L+ L
Sbjct: 808 VRCLKLEL 815
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 102 bits (253), Expect = 3e-21
Identities = 170/821 (20%), Positives = 337/821 (41%), Gaps = 157/821 (19%)
Query: 291 FQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHD 350
FQAA + YL RQ K K +Q+L + Q ++ + GV + + ++ L+E
Sbjct: 1195 FQAACRGYLARQHFK-KRKIQDLAIRCVQKNIKKNK-GVKDWPWWKLFTTVRPLIEVQ-- 1250
Query: 351 RHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD 410
++ + R K+EE+Q R+ K NE R L++ + L L D
Sbjct: 1251 ---LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL-------TD 1300
Query: 411 MRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAED 470
R+ +Q++ ER+RAE E K+ D L + + +E ++ +
Sbjct: 1301 ERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVM-----------E 1349
Query: 471 TRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKST 530
R++R A E E+D G + R + RAV E + +
Sbjct: 1350 ARLIRAA--EINGEVD--------------DDDAGGEWRLKYERAVREVDFTKKRLQQEF 1393
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLT- 589
+ ++E +++ + + +L + +E LQ+L +C RLT
Sbjct: 1394 EDKLEVEQQN---KRQLERRLGDLQADSEESQRALQQLKKKC-------------QRLTA 1437
Query: 590 -LQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKY 648
LQDT+ L Q+ L ++ + + EL + + A REKLQ
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRF------DSELSQAHEEAQREKLQRE--------- 1482
Query: 649 FNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNEL 708
+LQ+EK ++ + + + +DI + + +V L+ +++ ++
Sbjct: 1483 ------KLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQK-------VVSLEAELQDISSQ 1529
Query: 709 ITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDG 768
+ ++ +++ + KQL LE ++K + +DE G
Sbjct: 1530 ESKDEASLAK--------------VKKQLR------------DLEAKVKDQEEELDEQAG 1563
Query: 769 KAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLR-VESKIEQEKKEQK 827
+ LRL+ EM ++ Q +++ S D +E QKKL+ +E ++E+E ++++
Sbjct: 1564 TIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 828 EIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLN 887
++ ++L+ L L+ +N+ SE+ + + ++ KA + M D L
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESEKRLRKD-------LKRTKALLADAQLMLDHLK 1676
Query: 888 QLSEEK---ATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMK 944
+ K A L NQL E+E A +++ +AM+ EI +
Sbjct: 1677 NSAPSKREIAQLKNQLEESE---------FTCAAAVKAR----------KAMEVEIEDLH 1717
Query: 945 VRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRD 1004
+++ + K + A+E ++R + + + + + D++ + HK + + RD
Sbjct: 1718 LQIDDIAKAK----TALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHK-AAVAQASRD 1772
Query: 1005 VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSE 1064
+ + D +LEE + E QEKL +Q+ + LE + + RQ ++
Sbjct: 1773 LAQIND----LQAQLEEANKEKQ----ELQEKLQALQSQVEFLEQSMVDKSLVSRQE-AK 1823
Query: 1065 IVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLA 1105
I L+TRL+ + + R K+++ + D+R+A
Sbjct: 1824 IRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIA 1864
Score = 81.6 bits (200), Expect = 4e-15
Identities = 113/613 (18%), Positives = 263/613 (42%), Gaps = 66/613 (10%)
Query: 342 QKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHL 401
++L ++ D+ + +RQ E L +A ++ A + +KK L E+++ LHL
Sbjct: 1387 KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHL 1446
Query: 402 FYMQ----NIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEE-- 455
Q +++ R ++Q ++A+ E+++ E ++++D+ + + + QQLEE
Sbjct: 1447 EGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKD 1506
Query: 456 -DIALFEAQYLA-----------QAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSL 503
DIA F + ++ +++D L K V + +++A ++ + + A ++
Sbjct: 1507 MDIAGFTQKVVSLEAELQDISSQESKDEASLAK-VKKQLRDLEAKVKDQEEELDEQAGTI 1565
Query: 504 VGMKHRDEAHRAVLEALRGC-QHQAKSTDGEIEAYKKSIMK---------EEEKNEKLAS 553
++ +E +R + +S D E+E ++S K EEE +K
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 554 ILNRTETE---ATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTE--------DALSQDQL 602
+ + E E ATL ++ + + L+ + L D + A S+ ++
Sbjct: 1626 LREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREI 1685
Query: 603 EQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTN 662
Q L +L+ ++ R+ + I + + K + + RLQ+EK
Sbjct: 1686 AQ--LKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1743
Query: 663 MMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTIL 722
+ L + D+ + + H+ + + +D+ ++N+L + + L
Sbjct: 1744 IQNRLEEDQEDM----------NELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL 1793
Query: 723 IERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQ 782
E+ Q L + + + MV + V E +I+ L ++ + + + RL++
Sbjct: 1794 QEKLQALQSQVEFLEQSMVDK---SLVSRQEAKIRELETRLEFERTQVKRLESLASRLKE 1850
Query: 783 EMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKK 842
M K+T+E+++++A+ + K EQ K R++ ++ K+E E+ + +
Sbjct: 1851 NMEKLTEERDQRIAAENREK------EQNK-RLQRQLRDTKEEMGELARKEAEASRKKHE 1903
Query: 843 LNMLMNKNRCSSEELEQNNRVTENEF--VRSLKASERETIKMQDKLNQLSEEKATLLNQL 900
L M + +++ L+ + ++ +++ E E+ + +D +N SE + + ++L
Sbjct: 1904 LEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLIN--SEGDSDVDSEL 1961
Query: 901 VEAEHQIMLWEKK 913
+ + W K
Sbjct: 1962 EDRVDGVKSWLSK 1974
Score = 53.1 bits (126), Expect = 1e-06
Identities = 72/416 (17%), Positives = 177/416 (42%), Gaps = 65/416 (15%)
Query: 743 ELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASK 802
+L E++ + EI++L +++ + + + ++ RL+ + ++T E ++ + +++
Sbjct: 1250 QLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESAS 1309
Query: 803 KELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMN-------------- 848
+ L ++LR E ++++ + + ++ M+ ++ ++ + ++
Sbjct: 1310 QLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369
Query: 849 ----KNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQL---SEEKATLLNQLV 901
K + E++ + + EF L+ ++ +++ +L L SEE L QL
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLK 1429
Query: 902 EAEHQIM--LWEKKIQL---------AKEMRSSVDSEIGQTEIRAMKGEIHRMKVR---- 946
+ ++ L + K+ L ++ + DSE+ Q A + ++ R K++
Sbjct: 1430 KKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKD 1489
Query: 947 --------LGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQL-E 997
L Q L++++ I V E Q D +L + KQL +
Sbjct: 1490 MLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKV---KKQLRD 1546
Query: 998 LRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGAL 1057
L K++D + DE T+ LE+ + + +E + + ++ + ++
Sbjct: 1547 LEAKVKDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEE---- 1599
Query: 1058 KRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDR 1113
RQ + Q +LK ++ E Y KQ ++ E++ L+ +LA ++ ++R
Sbjct: 1600 ARQ------SCQKKLKQMEVQLEEEY----EDKQKVLREKRELEGKLATLSDQVNR 1645
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 102 bits (253), Expect = 3e-21
Identities = 170/821 (20%), Positives = 337/821 (41%), Gaps = 157/821 (19%)
Query: 291 FQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHD 350
FQAA + YL RQ K K +Q+L + Q ++ + GV + + ++ L+E
Sbjct: 1195 FQAACRGYLARQHFK-KRKIQDLAIRCVQKNIKKNK-GVKDWPWWKLFTTVRPLIEVQ-- 1250
Query: 351 RHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD 410
++ + R K+EE+Q R+ K NE R L++ + L L D
Sbjct: 1251 ---LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL-------TD 1300
Query: 411 MRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAED 470
R+ +Q++ ER+RAE E K+ D L + + +E ++ +
Sbjct: 1301 ERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVM-----------E 1349
Query: 471 TRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKST 530
R++R A E E+D G + R + RAV E + +
Sbjct: 1350 ARLIRAA--EINGEVD--------------DDDAGGEWRLKYERAVREVDFTKKRLQQEF 1393
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLT- 589
+ ++E +++ + + +L + +E LQ+L +C RLT
Sbjct: 1394 EDKLEVEQQN---KRQLERRLGDLQADSEESQRALQQLKKKC-------------QRLTA 1437
Query: 590 -LQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKY 648
LQDT+ L Q+ L ++ + + EL + + A REKLQ
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRF------DSELSQAHEEAQREKLQRE--------- 1482
Query: 649 FNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNEL 708
+LQ+EK ++ + + + +DI + + +V L+ +++ ++
Sbjct: 1483 ------KLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQK-------VVSLEAELQDISSQ 1529
Query: 709 ITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDG 768
+ ++ +++ + KQL LE ++K + +DE G
Sbjct: 1530 ESKDEASLAK--------------VKKQLR------------DLEAKVKDQEEELDEQAG 1563
Query: 769 KAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLR-VESKIEQEKKEQK 827
+ LRL+ EM ++ Q +++ S D +E QKKL+ +E ++E+E ++++
Sbjct: 1564 TIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQ 1623
Query: 828 EIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLN 887
++ ++L+ L L+ +N+ SE+ + + ++ KA + M D L
Sbjct: 1624 KVLREKRELEGKLATLSDQVNRRDFESEKRLRKD-------LKRTKALLADAQLMLDHLK 1676
Query: 888 QLSEEK---ATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMK 944
+ K A L NQL E+E A +++ +AM+ EI +
Sbjct: 1677 NSAPSKREIAQLKNQLEESE---------FTCAAAVKAR----------KAMEVEIEDLH 1717
Query: 945 VRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRD 1004
+++ + K + A+E ++R + + + + + D++ + HK + + RD
Sbjct: 1718 LQIDDIAKAK----TALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHK-AAVAQASRD 1772
Query: 1005 VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSE 1064
+ + D +LEE + E QEKL +Q+ + LE + + RQ ++
Sbjct: 1773 LAQIND----LQAQLEEANKEKQ----ELQEKLQALQSQVEFLEQSMVDKSLVSRQE-AK 1823
Query: 1065 IVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLA 1105
I L+TRL+ + + R K+++ + D+R+A
Sbjct: 1824 IRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIA 1864
Score = 85.1 bits (209), Expect = 3e-16
Identities = 123/626 (19%), Positives = 269/626 (42%), Gaps = 75/626 (11%)
Query: 342 QKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHL 401
++L ++ D+ + +RQ E L +A ++ A + +KK L E+++ LHL
Sbjct: 1387 KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHL 1446
Query: 402 FYMQ----NIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEE-- 455
Q +++ R ++Q ++A+ E+++ E ++++D+ + + + QQLEE
Sbjct: 1447 EGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKD 1506
Query: 456 -DIALFEAQYLA-----------QAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSL 503
DIA F + ++ +++D L K V + +++A ++ + + A ++
Sbjct: 1507 MDIAGFTQKVVSLEAELQDISSQESKDEASLAK-VKKQLRDLEAKVKDQEEELDEQAGTI 1565
Query: 504 VGMKHRDEAHRAVLEALRGC-QHQAKSTDGEIEAYKKSIMK---------EEEKNEKLAS 553
++ +E +R + +S D E+E ++S K EEE +K
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKV 1625
Query: 554 ILNRTETE---ATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTE--------DALSQDQL 602
+ + E E ATL ++ + + L+ + L D + A S+ ++
Sbjct: 1626 LREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREI 1685
Query: 603 EQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTN 662
Q L +L+ ++ R+ + I + + K + + RLQ+EK
Sbjct: 1686 AQ--LKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNE 1743
Query: 663 MMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTIL 722
+ L + D+ + + H+ + + +D+ ++N+L + + L
Sbjct: 1744 IQNRLEEDQEDM----------NELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL 1793
Query: 723 IERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQ 782
E+ Q L + + + MV + V E +I+ L ++ + + + RL++
Sbjct: 1794 QEKLQALQSQVEFLEQSMVDK---SLVSRQEAKIRELETRLEFERTQVKRLESLASRLKE 1850
Query: 783 EMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKK 842
M K+T+E+++++A+ + K EQ K R++ ++ K+E E+ K+ + KK
Sbjct: 1851 NMEKLTEERDQRIAAENREK------EQNK-RLQRQLRDTKEEMGELAR--KEAEASRKK 1901
Query: 843 LNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVE 902
+ M+ E LE N+ + + + K ++D++ S+E L+N L +
Sbjct: 1902 HELEMD-----LESLEAANQSLQADLKLAFKRIGDLQAAIEDEME--SDENEDLINSLQD 1954
Query: 903 AEHQIMLWEKKIQLAKEMRSSVDSEI 928
+ + K+ E S VDSE+
Sbjct: 1955 MVTKYQKRKNKL----EGDSDVDSEL 1976
Score = 53.1 bits (126), Expect = 1e-06
Identities = 72/416 (17%), Positives = 177/416 (42%), Gaps = 65/416 (15%)
Query: 743 ELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASK 802
+L E++ + EI++L +++ + + + ++ RL+ + ++T E ++ + +++
Sbjct: 1250 QLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESAS 1309
Query: 803 KELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMN-------------- 848
+ L ++LR E ++++ + + ++ M+ ++ ++ + ++
Sbjct: 1310 QLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369
Query: 849 ----KNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQL---SEEKATLLNQLV 901
K + E++ + + EF L+ ++ +++ +L L SEE L QL
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLK 1429
Query: 902 EAEHQIM--LWEKKIQL---------AKEMRSSVDSEIGQTEIRAMKGEIHRMKVR---- 946
+ ++ L + K+ L ++ + DSE+ Q A + ++ R K++
Sbjct: 1430 KKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKD 1489
Query: 947 --------LGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQL-E 997
L Q L++++ I V E Q D +L + KQL +
Sbjct: 1490 MLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKV---KKQLRD 1546
Query: 998 LRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGAL 1057
L K++D + DE T+ LE+ + + +E + + ++ + ++
Sbjct: 1547 LEAKVKDQEEELDEQAGTIQMLEQAKLRLE---MEMERMRQTHSKEMESRDEEVEE---- 1599
Query: 1058 KRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDR 1113
RQ + Q +LK ++ E Y KQ ++ E++ L+ +LA ++ ++R
Sbjct: 1600 ARQ------SCQKKLKQMEVQLEEEY----EDKQKVLREKRELEGKLATLSDQVNR 1645
Score = 37.7 bits (86), Expect = 0.063
Identities = 58/270 (21%), Positives = 107/270 (39%), Gaps = 24/270 (8%)
Query: 302 QIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQ 361
+IE L L + ++ A Q L E+Q L Q+ + + +H A ++ +
Sbjct: 1712 EIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASR 1771
Query: 362 KEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQV 421
++ +A + E ++KL ALQ+++E L +Q M D V Q
Sbjct: 1772 DLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL----------EQSMVDKSLVSRQE 1821
Query: 422 VKKAETERIRAEIEK---KKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAV 478
K E E R E E+ K+ + +L ++L E+ A + E + L++ +
Sbjct: 1822 AKIRELE-TRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQL 1880
Query: 479 SEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEAL-RGCQHQAKSTDGEIEAY 537
+ E+ ++ ++ ++ KH E LEA + Q K I
Sbjct: 1881 RDTKEEMGELARKEAEASRK--------KHELEMDLESLEAANQSLQADLKLAFKRIGDL 1932
Query: 538 KKSIMKEEEKNEKLASILNRTETEATLLQK 567
+ +I E E +E ++N + T QK
Sbjct: 1933 QAAIEDEMESDEN-EDLINSLQDMVTKYQK 1961
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 101 bits (252), Expect = 4e-21
Identities = 195/927 (21%), Positives = 395/927 (42%), Gaps = 125/927 (13%)
Query: 241 LPVFQDQIQQPSTEEGAMAERVESE--GSDEEAEDEGSQLVVLDPDHPLMVRFQAALK-- 296
+ V ++ TE ++ESE DE D+ S +++ + L VR A +
Sbjct: 440 MAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFS---LMNENRELKVRVAAQNERL 496
Query: 297 NYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSH---DRHA 353
+ ++IE +++L+ L Q +R+ G Y + + ++ + +
Sbjct: 497 DLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANK 556
Query: 354 MASSERRQK----EEELQAARALYTK--------TCAAANEERKKLAALQTEMENLALHL 401
+ SE R K E E+Q A T TC + +E KL++L+TE L H
Sbjct: 557 LVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDS-QESSKLSSLETEPVKLGGHQ 615
Query: 402 FYMQNIDQDM--------RDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQL 453
DQ+ ++ R++T + ++ T+ I+ E E + + T++ Q +
Sbjct: 616 VAESVKDQNQHTMNKQYEKERQRLVTGI-EELRTKLIQIEAENSDLKVNMAHRTSQFQLI 674
Query: 454 EEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAH 513
+E++ L +A ++ L +++ C+++ +++EK+ + A S + K+ E
Sbjct: 675 QEEL-------LEKASNSSKLESEMTKKCSQL--LTLEKQLEEKIVAYSSIAAKNA-ELE 724
Query: 514 RAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCL 573
+ ++E + +S + I + I EK +K+ L + + +++L Q
Sbjct: 725 QELMEK----NEKIRSLETNINTEHEKICLAFEKAKKIH--LEQHKEMEKQIERLEAQLE 778
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQM--ILTEELQAIRQAIQGELELRR-KTDA 630
K + Q T + QD Q LE + +LTE +GE++ K D
Sbjct: 779 KKDQQFKEQEKTMSMLQQDI--ICKQHHLESLDRLLTES--------KGEMKKENMKKDE 828
Query: 631 AIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDA 690
A+ K ++ S +T K QL L+ K ++ HL+++ G+ + + S +
Sbjct: 829 AL--KALQNQVSEETIKV-RQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC 885
Query: 691 HQKTLVELDQDVKKVNELITNSQSEISRRTILIER---KQGLINFLNKQLERMVSELGGE 747
QK L + +++ +E Q + ++ ++++ + G + +LE+ VS+L E
Sbjct: 886 LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE 945
Query: 748 EVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHI 807
E ++L K+ ++ + A +A + +Q+++++T + +D K+EL
Sbjct: 946 LQKQRESSAEKLRKMEEKCESAAHEADLK----RQKVIELTGTARQVKIEMDQYKEELSK 1001
Query: 808 MEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENE 867
ME++ + + K++ + H+ LD L + + K + +ELE+ TE E
Sbjct: 1002 MEKEIMHL-------KRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE 1054
Query: 868 FVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSE 927
+L+ E ++Q N E K+TL QL E + +K QL+ E + + +
Sbjct: 1055 LTEALQKREVLETELQ---NAHGELKSTL-RQLQELRDVL----QKAQLSLEEKYTTIKD 1106
Query: 928 IGQTEIRAMKGEIHRMK---VRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRK 984
+ E+R K EI K + + Q LK++ ++ V + + G+ +
Sbjct: 1107 L-TAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKII 1165
Query: 985 ALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADF 1044
L T +LEL+ EC K + L + +N L EK +F
Sbjct: 1166 KLEGT-LEKSELELK-----------ECNKQIESLNDKLQNAKEQLREK---------EF 1204
Query: 1045 DTLEADLTRLGALKRQNLSEIVALQTRLKHLQAV-KEGRYVFLFRSKQSLVLERQRLDKR 1103
L+ + + LK+ EI Q R+K +++V KE + K+++ L ++
Sbjct: 1205 IMLQNE-QEISQLKK----EIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE----- 1254
Query: 1104 LALIATILDRVRDEYPQFQEALHKVSQ 1130
+ ++V++ + + EA H+ Q
Sbjct: 1255 ---LRLTREQVQNSHTELAEARHQQVQ 1278
Score = 101 bits (252), Expect = 4e-21
Identities = 154/792 (19%), Positives = 325/792 (41%), Gaps = 125/792 (15%)
Query: 302 QIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASS---- 357
Q+ L+ L+E +VA A+ EL L E + + L+ + H++ +A
Sbjct: 698 QLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKK 757
Query: 358 ----ERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRD 413
+ ++ E++++ A K E+ K ++ LQ ++ HL + + + +
Sbjct: 758 IHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKG 817
Query: 414 DIR---VMTQVVKKAETERIRAEIEKKKQ-----DLYVDQLTTRAQQLEEDIALFEAQYL 465
+++ + KA ++ E K +Q ++ ++L QLE + FE Q
Sbjct: 818 EMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLK 877
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQH 525
++E+ L+K + K +Q+ + V ++H + + +L+
Sbjct: 878 KKSEEVYCLQKELKI-----------KNHSLQETSEQNVILQHTLQQQQQMLQ------- 919
Query: 526 QAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLT----------K 575
Q +GE+E + + K+ K E+ + + E+ A L+K+ +C + K
Sbjct: 920 QETIRNGELEDTQTKLEKQVSKLEQ--ELQKQRESSAEKLRKMEEKCESAAHEADLKRQK 977
Query: 576 QVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEE-------LQAIRQAI-QGELELRRK 627
+ L ++ + ++ LS+ + E M L + L + + Q + EL +K
Sbjct: 978 VIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKK 1037
Query: 628 TDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSR 687
T+A + +H T + T+ LQK + + T L +G++ T +
Sbjct: 1038 TNAVKELEKLQHSTETELTE-------ALQKREV-LETELQNAHGELKSTLRQLQELRDV 1089
Query: 688 LDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGE 747
L Q +L E +K + + + EI ++KQ L+ ER
Sbjct: 1090 LQKAQLSLEEKYTTIKDLTAELRECKMEIE------DKKQELLEMDQALKER------NW 1137
Query: 748 EVGPLELEIKRLSKLIDEHDG----KAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKK 803
E+ ++ L I EH G K ++ + T + + E+ + ++ E L +K+
Sbjct: 1138 ELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKE 1197
Query: 804 ELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRV 863
+L E L+ E +I Q KKE + + MK++++ +K+ + + +L Q R+
Sbjct: 1198 QLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRL 1257
Query: 864 TENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSS 923
T + +Q+ +L+E + +Q V+A+ +I +++ K++
Sbjct: 1258 TREQ--------------VQNSHTELAEAR----HQQVQAQREIERLSSELEDMKQLSKE 1299
Query: 924 VDS-------EIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAE 976
D+ E+G +++R E RM+ + +L + E + A +
Sbjct: 1300 KDAHGNHLAEELGASKVREAHLEA-RMQAEIKKLSAEVESLKEAYHM------------- 1345
Query: 977 GQRKMDRKALTRTDFHHK-QLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQE 1035
+ ++ + H K ++ + V++ ++ K LELEE Q VS+ + Q+
Sbjct: 1346 -------EMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQD 1398
Query: 1036 KLSVIQADFDTL 1047
+ VI+A + L
Sbjct: 1399 RNEVIEAANEAL 1410
Score = 90.5 bits (223), Expect = 8e-18
Identities = 175/979 (17%), Positives = 400/979 (40%), Gaps = 145/979 (14%)
Query: 234 AHPREGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQA 293
A + +P+ ++QI E A + + + E + E SQ +V++ + L +
Sbjct: 279 AQQQAASVPILEEQIINLEAEVSAQDKVLR----EAENKLEQSQKMVIEKEQSLQESKEE 334
Query: 294 ALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEV------------------- 334
+K LK+DL E K++ QR E N E+
Sbjct: 335 CIK---------LKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQ 385
Query: 335 ------QQHLVHLQKLLEKSHDRHAMASSE--------RRQKEE------ELQAARALYT 374
+++L + +K ++ +R + SE R+ KEE +L+ +
Sbjct: 386 AEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNS 445
Query: 375 KTCAAANEERKKLAALQTEMEN---LALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIR 431
+ A E R+ + L++E+EN + F + N +++++ + + + + E
Sbjct: 446 EVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIES 505
Query: 432 AEIEKKKQDLYVDQLTTRAQQL--EEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAIS 489
+ +E + + + QL + + + ++ ++ + ED I C E + +
Sbjct: 506 SRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCI-------GCCEANKLV 558
Query: 490 VEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGC---QHQAKSTDGEIEAYKKS--IMKE 544
+ + RI + + H + + ++L C Q +K + E E K + E
Sbjct: 559 ISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAE 618
Query: 545 EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQ 604
K++ ++ + E E L + TK + ++++ + ++ + Q
Sbjct: 619 SVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQF------Q 672
Query: 605 MILTEELQAIRQAIQGELELRRKTDA--AIREKLQEHMTSNKTTKYFNQLILRLQKEKTN 662
+I E L+ + + E E+ +K + ++L+E + + + N + + EK
Sbjct: 673 LIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNE 732
Query: 663 MMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTIL 722
+ L +T ++ H L + + L+Q K++ + I ++++ ++
Sbjct: 733 KIRSL--------ETNINTEHEKICLAFEKAKKIHLEQH-KEMEKQIERLEAQLEKKDQQ 783
Query: 723 IERKQGLINFLNKQ----------LERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQ 772
+ ++ ++ L + L+R+++E GE +K+ + DE KA+Q
Sbjct: 784 FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGE--------MKKENMKKDEAL-KALQ 834
Query: 773 AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHI----MEQKKLRVESKIEQEKKEQKE 828
QV+ +E +KV Q ++L+ K+EL + +E K + E +++++ +E
Sbjct: 835 NQVS-----EETIKVRQLD----SALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC 885
Query: 829 IEHHMKDLDNDLKKL---NMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDK 885
++ +K ++ L++ N+++ +++ Q + E + E++ K++ +
Sbjct: 886 LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE 945
Query: 886 LNQLSEEKATLLNQLVE----AEHQIMLWEKKIQLAKEMRSSVDSEIGQ--TEIRAMKGE 939
L + E A L ++ E A H+ L +K+ V E+ Q E+ M+ E
Sbjct: 946 LQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 1005
Query: 940 IHRMK----------VRLGQLLKQQEKMIRAMELAVARRETV--TTQAEGQRKMDRKALT 987
I +K +L +L Q + + AV E + +T+ E + ++ +
Sbjct: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
Query: 988 RTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQE-KLSVIQADFDT 1046
T+ + EL+ +R +++ D K L LEE + E +E K+ + +
Sbjct: 1066 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1125
Query: 1047 LEAD--LTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRL 1104
LE D L +Q +++ L ++ + E + + L + + LE + +K+
Sbjct: 1126 LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQ- 1184
Query: 1105 ALIATILDRVRDEYPQFQE 1123
I ++ D++++ Q +E
Sbjct: 1185 --IESLNDKLQNAKEQLRE 1201
Score = 49.3 bits (116), Expect = 2e-05
Identities = 78/459 (16%), Positives = 203/459 (44%), Gaps = 39/459 (8%)
Query: 669 KINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQG 728
K+N Q +T S + + EL Q KV+ L + Q S
Sbjct: 237 KLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS----------- 285
Query: 729 LINFLNKQLERMVSELGGEE--VGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVK 786
+ L +Q+ + +E+ ++ + E ++++ K++ E + +++ ++L+ ++++
Sbjct: 286 -VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLE 344
Query: 787 VTQE----QEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKK 842
T++ + ++ +L +++ +Q K +V K+E+ + E++ +E ++ + + + K+
Sbjct: 345 QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKR 404
Query: 843 LNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVE 902
L + E L++ R + E + +K + + QL+E + ++L E
Sbjct: 405 LQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESE 464
Query: 903 AEHQIMLWEKKIQLAKEMR--------SSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQ 954
E++ + K L E R + ++ Q EI + + E+ ++ + QL ++
Sbjct: 465 LENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKR 524
Query: 955 EKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRK-----AT 1009
E + + +++ + + + R + + +++L K +++K
Sbjct: 525 E--LFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTA 582
Query: 1010 DECTKTVLELEETQRNVSSSLLEKQE-KL---SVIQADFDTLEADLTRLGALKRQNL-SE 1064
++ +++++ ++Q + S LE + KL V ++ D + + + +RQ L +
Sbjct: 583 NQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTG 642
Query: 1065 IVALQTRLKHLQAVKEGRYV-FLFRSKQSLVLERQRLDK 1102
I L+T+L ++A V R+ Q +++ + L+K
Sbjct: 643 IEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK 681
Score = 38.5 bits (88), Expect = 0.037
Identities = 65/362 (17%), Positives = 147/362 (40%), Gaps = 37/362 (10%)
Query: 790 EQEEQLASLDASKKELHIMEQKKLRVESKIEQ----EKKEQKEIEHHMKDLDNDLKK--- 842
E+E LA++ + + EL I E + ++ E + + L D++
Sbjct: 132 EEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHP 191
Query: 843 --LNMLMNKNRC----SSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATL 896
LN +N C SS + ++ R ++ S ++E +++KLN+L ++ A L
Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPR---DKMFSSSAPVDQEIKSLREKLNKLRQQNACL 248
Query: 897 LNQLVEAEHQIMLWEKKIQL-AKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQE 955
+ Q H +M + I + R+ V + A + + L + Q+
Sbjct: 249 VTQ----NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQD 304
Query: 956 KMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKT 1015
K++R E + + + + + E + ++ + +++L + + ++A + +
Sbjct: 305 KVLREAENKLEQSQKMVIEKEQSLQESKEECIKL-----KVDLLEQTKQGKRAERQRNEA 359
Query: 1016 VLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHL 1075
+ EE + + EKL +QA+ + LE +LT +++N RL+
Sbjct: 360 LYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTN---CEKEN--------KRLQER 408
Query: 1076 QAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANK 1135
+ + L + L E ++L ++A V + + ++++ K+ + NK
Sbjct: 409 CGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENK 468
Query: 1136 LE 1137
E
Sbjct: 469 DE 470
Score = 37.0 bits (84), Expect = 0.11
Identities = 42/235 (17%), Positives = 98/235 (41%), Gaps = 25/235 (10%)
Query: 299 LNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSE 358
LN +++ K L+E Q+ + +L + QQ + ++ ++++ A E
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKE 1247
Query: 359 RRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD-------M 411
+EL+ R + E R + Q E+E L+ L M+ + ++ +
Sbjct: 1248 AIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHL 1307
Query: 412 RDDI------RVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYL 465
+++ + +AE +++ AE+E K+ +++ ++ +E+ A ++
Sbjct: 1308 AEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISH-----QENHAKWKISAD 1362
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEAL 520
+Q + L + + +A E++ + QQ ++ R+E A EAL
Sbjct: 1363 SQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQ-------VQDRNEVIEAANEAL 1410
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 100 bits (250), Expect = 6e-21
Identities = 193/918 (21%), Positives = 387/918 (42%), Gaps = 101/918 (11%)
Query: 287 LMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLE 346
+M R AA + Q +L ++ L+ T+Q Q L +VQ+ + +
Sbjct: 843 VMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVL-QARAQELQKVQELQQQSAREVG 901
Query: 347 KSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEME----NLALHLF 402
+ R A ER + E+L+A L CA A E R +LAA + E+E L +
Sbjct: 902 ELQGRVAQLEEERARLAEQLRAEAEL----CAEAEETRGRLAARKQELELVVSELEARVG 957
Query: 403 YMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQ--QLEEDIALF 460
+ + M+ + + + Q +++ E + AE E +Q L ++++TT A+ + EED+ L
Sbjct: 958 EEEECSRQMQTEKKRLQQHIQELEAH-LEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLL 1015
Query: 461 EAQYLAQAEDTRILRKAV----SEACTEIDAI-SVEKRRIMQQWASSLVGMKHR---DEA 512
E Q +++ ++L + S+A E + + S+ K R+ ++ +++ M+ R +E
Sbjct: 1016 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL--KYEATIADMEDRLRKEEK 1073
Query: 513 HRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETE--ATLLQK--- 567
R LE L+ + DGE ++ +++++++ E+L + L R E E A L +
Sbjct: 1074 GRQELEKLK------RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1127
Query: 568 --LTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGEL--- 622
Q L Q+ + L+ A ++ + ++ L EEL+A+R ++ L
Sbjct: 1128 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1187
Query: 623 ----ELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQK-------EKTNMMTHLSKIN 671
ELR K + + E + T + T+ + L++ E + +
Sbjct: 1188 NAQQELRSKREQEVTELKK---TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1244
Query: 672 GDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLIN 731
G +T L + S L A +L Q+ ++ + E+ R ER +
Sbjct: 1245 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARA--- 1301
Query: 732 FLNKQLERMVSELGGEEVGPLELEIK--RLSKLIDE-----HDGKAVQAQVTWLRL---- 780
++L+R +EL E E K RLSK + HD + + + T +L
Sbjct: 1302 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1361
Query: 781 -----QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKD 835
+ E + ++ EE+ A+ + + +EL + + + E+E + E +
Sbjct: 1362 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1421
Query: 836 LDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERE------TIKMQDKLNQ- 888
+ + L + + + + LE+ R + E + E++ K Q K +Q
Sbjct: 1422 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1481
Query: 889 LSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIG-----QTEIRAMKGEIHRM 943
L+EEKA +L + E E ++ A + +++ E + + RA++ E+ +
Sbjct: 1482 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
Query: 944 ---KVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRR 1000
K +G+ + + E+ R E A T+ E + A R + + L+ +
Sbjct: 1542 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1601
Query: 1001 KIRDV--RKATDECTKTVLELEETQRNVSSSLLEKQEKLSV-----IQADFDTLEADLTR 1053
+ RD+ R E + L + V KQ L+V ++ + + L+A +
Sbjct: 1602 E-RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1660
Query: 1054 LGALKRQNLSEIVALQTRLKHL-QAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILD 1112
G K + + ++ +Q ++K L + V+E R S++ + + + +KRL + +
Sbjct: 1661 AGQGKEEAVKQLRKMQAQMKELWREVEETR-----TSREEIFSQNRESEKRLKGLEAEVL 1715
Query: 1113 RVRDEYPQFQEALHKVSQ 1130
R+++E A + Q
Sbjct: 1716 RLQEELAASDRARRQAQQ 1733
Score = 93.2 bits (230), Expect = 1e-18
Identities = 183/956 (19%), Positives = 393/956 (41%), Gaps = 122/956 (12%)
Query: 238 EGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKN 297
E DL + +DQ + S E + +R+ +E S + AE+E + + L ++++A + +
Sbjct: 1009 EEDLLLLEDQNSKLSKERKLLEDRL-AEFSSQAAEEEEK----VKSLNKLRLKYEATIAD 1063
Query: 298 YLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASS 357
+R + K + QEL ++ + EL + E QQ L+ L +
Sbjct: 1064 MEDR-LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR---------- 1112
Query: 358 ERRQKEEELQAARA-------LYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD 410
KEEELQAA A + + E + LA Q ++E+ + + +D
Sbjct: 1113 ----KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1168
Query: 411 MRDDIRVMT-QVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAE 469
+ +++ + ++ ++ + E+ K++ ++T + LEE+ + EA
Sbjct: 1169 LGEELEALRGELEDTLDSTNAQQELRSKRE----QEVTELKKTLEEETRIHEAA------ 1218
Query: 470 DTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKS 529
+ LR+ +A E+ + RR W + + ++ RA L +L+ + + +
Sbjct: 1219 -VQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1277
Query: 530 TDGEIEAYKKSIMKE----EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNT 585
+E + + E + A L R + E + + +K + L + ++
Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1337
Query: 586 YRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKL-QEHMTSNK 644
L D ++ L ++ ++ L ++A+ G L + + +AA RE+ +E T+
Sbjct: 1338 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG-LREQLEEEAAARERAGRELQTAQA 1396
Query: 645 TTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKK 704
+ R Q+E+ + G+ A+ + +A + L E + V +
Sbjct: 1397 QLSEWR----RRQEEEAGALE-----AGEEAR-----RRAAREAEALTQRLAEKTETVDR 1442
Query: 705 VNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLID 764
+ Q E+ T+ +E+++ L++ L K+ +R +L EE + ++ +
Sbjct: 1443 LERGRRRLQQELDDATMDLEQQRQLVSTLEKK-QRKFDQLLAEEKAAVLRAVEERERA-- 1499
Query: 765 EHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKK 824
E +G+ +A+ + + +E++E L+ + L + L + + +
Sbjct: 1500 EAEGREREARAL------SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1553
Query: 825 EQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQD 884
E + + NDL+ + ++E+ + VT V++LK ++ +D
Sbjct: 1554 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT----VQALKTQHERDLQGRD 1609
Query: 885 KLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEI----------GQTEIR 934
+ + E + L QL +AE + K+ LA R ++ E+ GQ +
Sbjct: 1610 EAGE--ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1667
Query: 935 AMKGEIHRMKVRLGQLL-----------------KQQEKMIRAMELAVARRE---TVTTQ 974
A+K ++ +M+ ++ +L ++ EK ++ +E V R + + +
Sbjct: 1668 AVK-QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1726
Query: 975 AEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQ 1034
A Q + DR + + + L + + R+ + ELEE Q N S LL +
Sbjct: 1727 ARRQAQQDRDEMA-DEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN--SELLNDR 1783
Query: 1035 EKLSVIQADFDTLEADLTRLGALK----RQNLS-EIVALQTRLKHLQAVKEGRYVFLFRS 1089
+ ++Q + T E R + K RQ L +I L+ RL A R+ +
Sbjct: 1784 YRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAA 1843
Query: 1090 KQSLV------LERQRLDKRLA--LIATILDRVRDEYPQFQEALHKVSQMIANKLE 1137
+S + LE++ ++ L+ L+ R+++ Q +E +V+ + ++LE
Sbjct: 1844 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE-RRVADQLRDQLE 1898
Score = 63.9 bits (154), Expect = 8e-10
Identities = 112/519 (21%), Positives = 219/519 (42%), Gaps = 53/519 (10%)
Query: 299 LNRQIEKLKLDL--QELVVAT--KQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAM 354
L ++++ +DL Q +V+T K+ R Q L V + + ++ + +R A
Sbjct: 1450 LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREAR 1509
Query: 355 ASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN---IDQDM 411
A S R EEE +A L + A R +L AL + +++ + ++ + +
Sbjct: 1510 ALSLTRALEEEQEAREELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQA 1565
Query: 412 RDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDT 471
+D+R V + E E AE K + ++ V L T Q E D+ + + A E
Sbjct: 1566 ANDLRAQ---VTELEDELTAAEDAKLRLEVTVQALKT---QHERDL---QGRDEAGEERR 1616
Query: 472 RILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTD 531
R L K + +A E D E+R+ ++ ++ E +A + + + +A
Sbjct: 1617 RQLAKQLRDAEVERD----EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1672
Query: 532 GEIEAYKKSIMKE-EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTL 590
+++A K + +E EE I ++ L+ L + L Q L + R
Sbjct: 1673 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ 1732
Query: 591 QDTE---DALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTK 647
QD + D ++ L + + EE ++ ++G L + E+L+E ++++
Sbjct: 1733 QDRDEMADEVANGNLSKAAILEE----KRQLEGRL-------GQLEEELEEEQSNSELLN 1781
Query: 648 -YFNQLILRLQKEKTNMMTHLS---KINGDIAQTTLDITHTSSRL---DA-----HQKTL 695
+ +L+L+++ T + S K Q I RL DA H+ T+
Sbjct: 1782 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1841
Query: 696 VELDQDVKKVNELITNSQSEISRRTILIERKQGLIN--FLNKQLERMVSELGGEEVGPLE 753
L+ + + E + E L+ R + + L + ER V++ +++
Sbjct: 1842 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1901
Query: 754 LEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQE 792
L +K+L + ++E + +A +AQ RLQ+E+ VT+ E
Sbjct: 1902 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAE 1940
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 100 bits (250), Expect = 6e-21
Identities = 193/918 (21%), Positives = 387/918 (42%), Gaps = 101/918 (11%)
Query: 287 LMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLE 346
+M R AA + Q +L ++ L+ T+Q Q L +VQ+ + +
Sbjct: 835 VMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVL-QARAQELQKVQELQQQSAREVG 893
Query: 347 KSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEME----NLALHLF 402
+ R A ER + E+L+A L CA A E R +LAA + E+E L +
Sbjct: 894 ELQGRVAQLEEERARLAEQLRAEAEL----CAEAEETRGRLAARKQELELVVSELEARVG 949
Query: 403 YMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQ--QLEEDIALF 460
+ + M+ + + + Q +++ E + AE E +Q L ++++TT A+ + EED+ L
Sbjct: 950 EEEECSRQMQTEKKRLQQHIQELEAH-LEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLL 1007
Query: 461 EAQYLAQAEDTRILRKAV----SEACTEIDAI-SVEKRRIMQQWASSLVGMKHR---DEA 512
E Q +++ ++L + S+A E + + S+ K R+ ++ +++ M+ R +E
Sbjct: 1008 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL--KYEATIADMEDRLRKEEK 1065
Query: 513 HRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETE--ATLLQK--- 567
R LE L+ + DGE ++ +++++++ E+L + L R E E A L +
Sbjct: 1066 GRQELEKLK------RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1119
Query: 568 --LTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGEL--- 622
Q L Q+ + L+ A ++ + ++ L EEL+A+R ++ L
Sbjct: 1120 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1179
Query: 623 ----ELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQK-------EKTNMMTHLSKIN 671
ELR K + + E + T + T+ + L++ E + +
Sbjct: 1180 NAQQELRSKREQEVTELKK---TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1236
Query: 672 GDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLIN 731
G +T L + S L A +L Q+ ++ + E+ R ER +
Sbjct: 1237 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARA--- 1293
Query: 732 FLNKQLERMVSELGGEEVGPLELEIK--RLSKLIDE-----HDGKAVQAQVTWLRL---- 780
++L+R +EL E E K RLSK + HD + + + T +L
Sbjct: 1294 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1353
Query: 781 -----QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKD 835
+ E + ++ EE+ A+ + + +EL + + + E+E + E +
Sbjct: 1354 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1413
Query: 836 LDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERE------TIKMQDKLNQ- 888
+ + L + + + + LE+ R + E + E++ K Q K +Q
Sbjct: 1414 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1473
Query: 889 LSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIG-----QTEIRAMKGEIHRM 943
L+EEKA +L + E E ++ A + +++ E + + RA++ E+ +
Sbjct: 1474 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
Query: 944 ---KVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRR 1000
K +G+ + + E+ R E A T+ E + A R + + L+ +
Sbjct: 1534 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1593
Query: 1001 KIRDV--RKATDECTKTVLELEETQRNVSSSLLEKQEKLSV-----IQADFDTLEADLTR 1053
+ RD+ R E + L + V KQ L+V ++ + + L+A +
Sbjct: 1594 E-RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1652
Query: 1054 LGALKRQNLSEIVALQTRLKHL-QAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILD 1112
G K + + ++ +Q ++K L + V+E R S++ + + + +KRL + +
Sbjct: 1653 AGQGKEEAVKQLRKMQAQMKELWREVEETR-----TSREEIFSQNRESEKRLKGLEAEVL 1707
Query: 1113 RVRDEYPQFQEALHKVSQ 1130
R+++E A + Q
Sbjct: 1708 RLQEELAASDRARRQAQQ 1725
Score = 93.2 bits (230), Expect = 1e-18
Identities = 183/956 (19%), Positives = 393/956 (41%), Gaps = 122/956 (12%)
Query: 238 EGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKN 297
E DL + +DQ + S E + +R+ +E S + AE+E + + L ++++A + +
Sbjct: 1001 EEDLLLLEDQNSKLSKERKLLEDRL-AEFSSQAAEEEEK----VKSLNKLRLKYEATIAD 1055
Query: 298 YLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASS 357
+R + K + QEL ++ + EL + E QQ L+ L +
Sbjct: 1056 MEDR-LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR---------- 1104
Query: 358 ERRQKEEELQAARA-------LYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD 410
KEEELQAA A + + E + LA Q ++E+ + + +D
Sbjct: 1105 ----KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1160
Query: 411 MRDDIRVMT-QVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAE 469
+ +++ + ++ ++ + E+ K++ ++T + LEE+ + EA
Sbjct: 1161 LGEELEALRGELEDTLDSTNAQQELRSKRE----QEVTELKKTLEEETRIHEAA------ 1210
Query: 470 DTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKS 529
+ LR+ +A E+ + RR W + + ++ RA L +L+ + + +
Sbjct: 1211 -VQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1269
Query: 530 TDGEIEAYKKSIMKE----EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNT 585
+E + + E + A L R + E + + +K + L + ++
Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1329
Query: 586 YRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKL-QEHMTSNK 644
L D ++ L ++ ++ L ++A+ G L + + +AA RE+ +E T+
Sbjct: 1330 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG-LREQLEEEAAARERAGRELQTAQA 1388
Query: 645 TTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKK 704
+ R Q+E+ + G+ A+ + +A + L E + V +
Sbjct: 1389 QLSEWR----RRQEEEAGALE-----AGEEAR-----RRAAREAEALTQRLAEKTETVDR 1434
Query: 705 VNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLID 764
+ Q E+ T+ +E+++ L++ L K+ +R +L EE + ++ +
Sbjct: 1435 LERGRRRLQQELDDATMDLEQQRQLVSTLEKK-QRKFDQLLAEEKAAVLRAVEERERA-- 1491
Query: 765 EHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKK 824
E +G+ +A+ + + +E++E L+ + L + L + + +
Sbjct: 1492 EAEGREREARAL------SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1545
Query: 825 EQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQD 884
E + + NDL+ + ++E+ + VT V++LK ++ +D
Sbjct: 1546 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT----VQALKTQHERDLQGRD 1601
Query: 885 KLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEI----------GQTEIR 934
+ + E + L QL +AE + K+ LA R ++ E+ GQ +
Sbjct: 1602 EAGE--ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1659
Query: 935 AMKGEIHRMKVRLGQLL-----------------KQQEKMIRAMELAVARRE---TVTTQ 974
A+K ++ +M+ ++ +L ++ EK ++ +E V R + + +
Sbjct: 1660 AVK-QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1718
Query: 975 AEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQ 1034
A Q + DR + + + L + + R+ + ELEE Q N S LL +
Sbjct: 1719 ARRQAQQDRDEMA-DEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN--SELLNDR 1775
Query: 1035 EKLSVIQADFDTLEADLTRLGALK----RQNLS-EIVALQTRLKHLQAVKEGRYVFLFRS 1089
+ ++Q + T E R + K RQ L +I L+ RL A R+ +
Sbjct: 1776 YRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAA 1835
Query: 1090 KQSLV------LERQRLDKRLA--LIATILDRVRDEYPQFQEALHKVSQMIANKLE 1137
+S + LE++ ++ L+ L+ R+++ Q +E +V+ + ++LE
Sbjct: 1836 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE-RRVADQLRDQLE 1890
Score = 63.9 bits (154), Expect = 8e-10
Identities = 112/519 (21%), Positives = 219/519 (42%), Gaps = 53/519 (10%)
Query: 299 LNRQIEKLKLDL--QELVVAT--KQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAM 354
L ++++ +DL Q +V+T K+ R Q L V + + ++ + +R A
Sbjct: 1442 LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREAR 1501
Query: 355 ASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN---IDQDM 411
A S R EEE +A L + A R +L AL + +++ + ++ + +
Sbjct: 1502 ALSLTRALEEEQEAREELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQA 1557
Query: 412 RDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDT 471
+D+R V + E E AE K + ++ V L T Q E D+ + + A E
Sbjct: 1558 ANDLRAQ---VTELEDELTAAEDAKLRLEVTVQALKT---QHERDL---QGRDEAGEERR 1608
Query: 472 RILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTD 531
R L K + +A E D E+R+ ++ ++ E +A + + + +A
Sbjct: 1609 RQLAKQLRDAEVERD----EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1664
Query: 532 GEIEAYKKSIMKE-EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTL 590
+++A K + +E EE I ++ L+ L + L Q L + R
Sbjct: 1665 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ 1724
Query: 591 QDTE---DALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTK 647
QD + D ++ L + + EE ++ ++G L + E+L+E ++++
Sbjct: 1725 QDRDEMADEVANGNLSKAAILEE----KRQLEGRL-------GQLEEELEEEQSNSELLN 1773
Query: 648 -YFNQLILRLQKEKTNMMTHLS---KINGDIAQTTLDITHTSSRL---DA-----HQKTL 695
+ +L+L+++ T + S K Q I RL DA H+ T+
Sbjct: 1774 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1833
Query: 696 VELDQDVKKVNELITNSQSEISRRTILIERKQGLIN--FLNKQLERMVSELGGEEVGPLE 753
L+ + + E + E L+ R + + L + ER V++ +++
Sbjct: 1834 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1893
Query: 754 LEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQE 792
L +K+L + ++E + +A +AQ RLQ+E+ VT+ E
Sbjct: 1894 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAE 1932
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 100 bits (250), Expect = 6e-21
Identities = 193/918 (21%), Positives = 387/918 (42%), Gaps = 101/918 (11%)
Query: 287 LMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLE 346
+M R AA + Q +L ++ L+ T+Q Q L +VQ+ + +
Sbjct: 876 VMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVL-QARAQELQKVQELQQQSAREVG 934
Query: 347 KSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEME----NLALHLF 402
+ R A ER + E+L+A L CA A E R +LAA + E+E L +
Sbjct: 935 ELQGRVAQLEEERARLAEQLRAEAEL----CAEAEETRGRLAARKQELELVVSELEARVG 990
Query: 403 YMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQ--QLEEDIALF 460
+ + M+ + + + Q +++ E + AE E +Q L ++++TT A+ + EED+ L
Sbjct: 991 EEEECSRQMQTEKKRLQQHIQELEAH-LEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLL 1048
Query: 461 EAQYLAQAEDTRILRKAV----SEACTEIDAI-SVEKRRIMQQWASSLVGMKHR---DEA 512
E Q +++ ++L + S+A E + + S+ K R+ ++ +++ M+ R +E
Sbjct: 1049 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL--KYEATIADMEDRLRKEEK 1106
Query: 513 HRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETE--ATLLQK--- 567
R LE L+ + DGE ++ +++++++ E+L + L R E E A L +
Sbjct: 1107 GRQELEKLK------RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1160
Query: 568 --LTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGEL--- 622
Q L Q+ + L+ A ++ + ++ L EEL+A+R ++ L
Sbjct: 1161 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1220
Query: 623 ----ELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQK-------EKTNMMTHLSKIN 671
ELR K + + E + T + T+ + L++ E + +
Sbjct: 1221 NAQQELRSKREQEVTELKK---TLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1277
Query: 672 GDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLIN 731
G +T L + S L A +L Q+ ++ + E+ R ER +
Sbjct: 1278 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARA--- 1334
Query: 732 FLNKQLERMVSELGGEEVGPLELEIK--RLSKLIDE-----HDGKAVQAQVTWLRL---- 780
++L+R +EL E E K RLSK + HD + + + T +L
Sbjct: 1335 EAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS 1394
Query: 781 -----QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKD 835
+ E + ++ EE+ A+ + + +EL + + + E+E + E +
Sbjct: 1395 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1454
Query: 836 LDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERE------TIKMQDKLNQ- 888
+ + L + + + + LE+ R + E + E++ K Q K +Q
Sbjct: 1455 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1514
Query: 889 LSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIG-----QTEIRAMKGEIHRM 943
L+EEKA +L + E E ++ A + +++ E + + RA++ E+ +
Sbjct: 1515 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
Query: 944 ---KVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRR 1000
K +G+ + + E+ R E A T+ E + A R + + L+ +
Sbjct: 1575 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1634
Query: 1001 KIRDV--RKATDECTKTVLELEETQRNVSSSLLEKQEKLSV-----IQADFDTLEADLTR 1053
+ RD+ R E + L + V KQ L+V ++ + + L+A +
Sbjct: 1635 E-RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1693
Query: 1054 LGALKRQNLSEIVALQTRLKHL-QAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILD 1112
G K + + ++ +Q ++K L + V+E R S++ + + + +KRL + +
Sbjct: 1694 AGQGKEEAVKQLRKMQAQMKELWREVEETR-----TSREEIFSQNRESEKRLKGLEAEVL 1748
Query: 1113 RVRDEYPQFQEALHKVSQ 1130
R+++E A + Q
Sbjct: 1749 RLQEELAASDRARRQAQQ 1766
Score = 93.2 bits (230), Expect = 1e-18
Identities = 183/956 (19%), Positives = 393/956 (41%), Gaps = 122/956 (12%)
Query: 238 EGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKN 297
E DL + +DQ + S E + +R+ +E S + AE+E + + L ++++A + +
Sbjct: 1042 EEDLLLLEDQNSKLSKERKLLEDRL-AEFSSQAAEEEEK----VKSLNKLRLKYEATIAD 1096
Query: 298 YLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASS 357
+R + K + QEL ++ + EL + E QQ L+ L +
Sbjct: 1097 MEDR-LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR---------- 1145
Query: 358 ERRQKEEELQAARA-------LYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQD 410
KEEELQAA A + + E + LA Q ++E+ + + +D
Sbjct: 1146 ----KEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRD 1201
Query: 411 MRDDIRVMT-QVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAE 469
+ +++ + ++ ++ + E+ K++ ++T + LEE+ + EA
Sbjct: 1202 LGEELEALRGELEDTLDSTNAQQELRSKRE----QEVTELKKTLEEETRIHEAA------ 1251
Query: 470 DTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKS 529
+ LR+ +A E+ + RR W + + ++ RA L +L+ + + +
Sbjct: 1252 -VQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1310
Query: 530 TDGEIEAYKKSIMKE----EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNT 585
+E + + E + A L R + E + + +K + L + ++
Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1370
Query: 586 YRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKL-QEHMTSNK 644
L D ++ L ++ ++ L ++A+ G L + + +AA RE+ +E T+
Sbjct: 1371 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG-LREQLEEEAAARERAGRELQTAQA 1429
Query: 645 TTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKK 704
+ R Q+E+ + G+ A+ + +A + L E + V +
Sbjct: 1430 QLSEWR----RRQEEEAGALE-----AGEEAR-----RRAAREAEALTQRLAEKTETVDR 1475
Query: 705 VNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLID 764
+ Q E+ T+ +E+++ L++ L K+ +R +L EE + ++ +
Sbjct: 1476 LERGRRRLQQELDDATMDLEQQRQLVSTLEKK-QRKFDQLLAEEKAAVLRAVEERERA-- 1532
Query: 765 EHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKK 824
E +G+ +A+ + + +E++E L+ + L + L + + +
Sbjct: 1533 EAEGREREARAL------SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVH 1586
Query: 825 EQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQD 884
E + + NDL+ + ++E+ + VT V++LK ++ +D
Sbjct: 1587 ELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT----VQALKTQHERDLQGRD 1642
Query: 885 KLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEI----------GQTEIR 934
+ + E + L QL +AE + K+ LA R ++ E+ GQ +
Sbjct: 1643 EAGE--ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1700
Query: 935 AMKGEIHRMKVRLGQLL-----------------KQQEKMIRAMELAVARRE---TVTTQ 974
A+K ++ +M+ ++ +L ++ EK ++ +E V R + + +
Sbjct: 1701 AVK-QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDR 1759
Query: 975 AEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQ 1034
A Q + DR + + + L + + R+ + ELEE Q N S LL +
Sbjct: 1760 ARRQAQQDRDEMA-DEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN--SELLNDR 1816
Query: 1035 EKLSVIQADFDTLEADLTRLGALK----RQNLS-EIVALQTRLKHLQAVKEGRYVFLFRS 1089
+ ++Q + T E R + K RQ L +I L+ RL A R+ +
Sbjct: 1817 YRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAA 1876
Query: 1090 KQSLV------LERQRLDKRLA--LIATILDRVRDEYPQFQEALHKVSQMIANKLE 1137
+S + LE++ ++ L+ L+ R+++ Q +E +V+ + ++LE
Sbjct: 1877 LESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE-RRVADQLRDQLE 1931
Score = 63.9 bits (154), Expect = 8e-10
Identities = 112/519 (21%), Positives = 219/519 (42%), Gaps = 53/519 (10%)
Query: 299 LNRQIEKLKLDL--QELVVAT--KQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAM 354
L ++++ +DL Q +V+T K+ R Q L V + + ++ + +R A
Sbjct: 1483 LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREAR 1542
Query: 355 ASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN---IDQDM 411
A S R EEE +A L + A R +L AL + +++ + ++ + +
Sbjct: 1543 ALSLTRALEEEQEAREELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQA 1598
Query: 412 RDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDT 471
+D+R V + E E AE K + ++ V L T Q E D+ + + A E
Sbjct: 1599 ANDLRAQ---VTELEDELTAAEDAKLRLEVTVQALKT---QHERDL---QGRDEAGEERR 1649
Query: 472 RILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTD 531
R L K + +A E D E+R+ ++ ++ E +A + + + +A
Sbjct: 1650 RQLAKQLRDAEVERD----EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1705
Query: 532 GEIEAYKKSIMKE-EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTL 590
+++A K + +E EE I ++ L+ L + L Q L + R
Sbjct: 1706 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ 1765
Query: 591 QDTE---DALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTK 647
QD + D ++ L + + EE ++ ++G L + E+L+E ++++
Sbjct: 1766 QDRDEMADEVANGNLSKAAILEE----KRQLEGRL-------GQLEEELEEEQSNSELLN 1814
Query: 648 -YFNQLILRLQKEKTNMMTHLS---KINGDIAQTTLDITHTSSRL---DA-----HQKTL 695
+ +L+L+++ T + S K Q I RL DA H+ T+
Sbjct: 1815 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1874
Query: 696 VELDQDVKKVNELITNSQSEISRRTILIERKQGLIN--FLNKQLERMVSELGGEEVGPLE 753
L+ + + E + E L+ R + + L + ER V++ +++
Sbjct: 1875 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1934
Query: 754 LEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQE 792
L +K+L + ++E + +A +AQ RLQ+E+ VT+ E
Sbjct: 1935 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAE 1973
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 100 bits (249), Expect = 8e-21
Identities = 157/837 (18%), Positives = 355/837 (42%), Gaps = 100/837 (11%)
Query: 240 DLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYL 299
+L + + + ++ +TE E G DE + L H + A ++ +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 300 NRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKS-----HDRHAM 354
N + K K+ L++ V + S Q +++ ++L ++ L KL ++S +D+ +
Sbjct: 1022 NT-LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 355 ASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDD 414
+ ++KE E+ ++ A + +KK+ LQ +E L
Sbjct: 1081 -DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE---------------- 1123
Query: 415 IRVMTQVVKKAETERI-RAEIEKKKQDLYVDQLTTRAQQLEE----DIALFEAQYLAQAE 469
++ E ER RA+ EK++ DL +L +++LEE A E +AE
Sbjct: 1124 --------EEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 470 DTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKS 529
+ +R+ + EA + +A + R+ + A S+ + + + + V + L + + K
Sbjct: 1175 FQK-MRRDLEEATLQHEATAATLRK---KHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 530 TDGEIEAYKKSIMKEEEKNEKLASIL----NRTETEATLLQKLTTQCLTKQVALQSQFNT 585
++ + +++ K + EK+ L + +T+ Q+L ++ LQ++
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGE 1290
Query: 586 YRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKT 645
Y L + + +SQ + T++++ +++ ++ E+ K +A+ LQ +S
Sbjct: 1291 YSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI----KAKSALAHALQ---SSRHD 1343
Query: 646 TKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKV 705
+ Q+ K + +SK N ++AQ T DA Q+T EL++ KK+
Sbjct: 1344 CDLLREQYEEEQEAKAELQRAMSKANSEVAQW-----RTKYETDAIQRT-EELEEAKKKL 1397
Query: 706 NELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKR--LSKLI 763
+ + +++ + + L ++E ++ ++ L+ K+ K++
Sbjct: 1398 AQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKIL 1457
Query: 764 DEHDGKAVQ-------AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVE 816
E K + +Q L E+ K+ EE L L+ K+E ++Q+ +
Sbjct: 1458 AEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1517
Query: 817 SKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASE 876
+I + K E+E K ++ + +L + + EE E SL+ E
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSEL-------QAALEEAE-----------ASLEHEE 1559
Query: 877 RETIKMQDKLNQLSEEKATLLNQLVEAEHQI-MLWEKKIQLAKEMRSSVDSEIGQTE--- 932
+ +++Q +LNQ+ K+ + ++ E + +I + I++ + M+S++D+EI
Sbjct: 1560 GKILRIQLELNQV---KSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI 1616
Query: 933 --IRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTD 990
+ M+G+++ M+++L + + +R R T + Q +D ++ D
Sbjct: 1617 RLKKKMEGDLNEMEIQLNHANRMAAEALRNY------RNTQAILKDTQLHLDDALRSQED 1670
Query: 991 FHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTL 1047
+ + R+ ++ +E T+ + E +++ LL+ E++ ++ +L
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1727
Score = 100 bits (248), Expect = 1e-20
Identities = 178/926 (19%), Positives = 383/926 (41%), Gaps = 99/926 (10%)
Query: 216 DLEEFVSQEPVIPPGVPDAHPR-EGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDE 274
DLE + QE I + A + EGDL + Q+ ++ + E+++ + E E
Sbjct: 1037 DLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK----EFEMS 1092
Query: 275 GSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEV 334
G Q + D + L ++ Q +K L +IE+L+ +++ + ++ QR +L L E+
Sbjct: 1093 GLQSKIED-EQALGMQLQKKIKE-LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1150
Query: 335 QQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERK-KLAALQTE 393
+ L + + +E ++ +L+ A + T A ++ +A L +
Sbjct: 1151 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1210
Query: 394 MENLALHLFYMQNIDQDMR---DDIRVMTQVVKKAETERIRAEIEKKKQDL--YVDQLTT 448
++NL ++ +M+ DD+ + V KA + +EK + L + ++ T
Sbjct: 1211 IDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKA-----KGNLEKMCRALEDQLSEIKT 1265
Query: 449 RAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKH 508
+ ++ + I AQ ++ + + E T + +S K+ QQ ++
Sbjct: 1266 KEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE 1325
Query: 509 RDEAHRAVLEALRGCQHQA----KSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATL 564
+A A+ AL+ +H + + E EA + + N ++A + ET+A
Sbjct: 1326 EIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQ 1385
Query: 565 -------LQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQA 617
+K Q L N +L+ T+ L + + MI E A A
Sbjct: 1386 RTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAA 1445
Query: 618 IQGELELRRKTDAAIREKLQE-HMTSNKTTKYFNQLILRLQK------EKTNMMTHLSKI 670
+ + K A ++K +E H + K L L K E + + L +
Sbjct: 1446 LDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRE 1505
Query: 671 NGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLI 730
N ++ Q D+T ++ K + EL++ K+V + + Q+ + +E ++G I
Sbjct: 1506 NKNLQQEISDLTE---QIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKI 1562
Query: 731 NFLNKQLERMVSELGGEEVGPLELEIKRLSK---LIDEHDGKAVQAQVTWLRLQQEMVKV 787
+ +L ++ SE+ ++ + EI ++ + I E + A++ R + + +++
Sbjct: 1563 LRIQLELNQVKSEVD-RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEI---RSRNDAIRL 1618
Query: 788 TQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKE-QKEIEHHMKDLDNDLKKLNML 846
++ E L ++ + M + LR + K+ Q ++ ++ ++ ++L M+
Sbjct: 1619 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV 1678
Query: 847 MNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLN-------- 898
+ E+E+ R T + RS K +E+E + +++ L + +L+N
Sbjct: 1679 ERRANLLQAEIEEL-RATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737
Query: 899 -QLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMK---GEIHRMKVRLGQLLKQ- 953
++ E + ++ E + K ++ D+ + E++ + + RMK L Q +K
Sbjct: 1738 ISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1797
Query: 954 QEKMIRAMELAV-----------ARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKI 1002
Q ++ A +LA+ AR + + E ++K + +A+ H RK+
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHE------RKV 1851
Query: 1003 RDVRKATDECTKTVLELE--------------------ETQRNVSSSLLEK-QEKLSVIQ 1041
+++ T+E K +L L+ E Q NV+ S + Q +L +
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
Query: 1042 ADFDTLEADLTRLGALKRQNLSEIVA 1067
D E+ + +L R+ ++I++
Sbjct: 1912 ERADIAESQVNKLRVKSREVHTKIIS 1937
Score = 87.4 bits (215), Expect = 7e-17
Identities = 105/521 (20%), Positives = 238/521 (45%), Gaps = 25/521 (4%)
Query: 538 KKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDAL 597
+K + +E+ EK L +TE + L++ + ++ LQ Q +L D E+
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERC 909
Query: 598 SQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQ 657
Q ++ L +++ + + + E E+ + A R+ E K + +++
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 658 KEK---TNMMTHLSKINGDIAQTTLDITHTSSRL-DAHQKTLVELDQDVKKVNELITNSQ 713
KEK N + +L++ + +T +T L +AHQ+TL +L + KVN L T ++
Sbjct: 970 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL-TKAK 1028
Query: 714 SEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQA 773
++ ++ +E + LER +L G +L++ + S + E+D + +
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEG------DLKLAQESTMDIENDKQQLDE 1082
Query: 774 QVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHM 833
++ + + EM + + E++ A +K++ ++ + +E +IE E+ + + E
Sbjct: 1083 KLK--KKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 834 KDLDNDLKKLN-MLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEE 892
DL +L++++ L +S ++E N + E EF + + E T++ + L ++
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKK-REAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 893 KATLLNQLVEAEHQIMLWEKKIQLAK-EMRSSVDSEIGQTE-IRAMKGEIHRM----KVR 946
A + +L E + ++K++ K EM+ +D E + KG + +M + +
Sbjct: 1200 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQ 1259
Query: 947 LGQLLKQQEKMIRAMELAVARRETVTTQA-EGQRKMDRKALTRTDFHHKQLELRRKIRDV 1005
L ++ ++E+ R + A+R + T++ E R++D K + + ++I ++
Sbjct: 1260 LSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319
Query: 1006 RKATDECTKTVLELE---ETQRNVSSSLLEKQEKLSVIQAD 1043
++ +E K L ++ R+ L E+ E+ +A+
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Score = 82.0 bits (201), Expect = 3e-15
Identities = 163/871 (18%), Positives = 353/871 (40%), Gaps = 99/871 (11%)
Query: 287 LMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLE 346
L+ R QA + +L R + ++ +E + + + R + V + + ++ LL+
Sbjct: 788 LITRTQAMCRGFLARVEYQKMVERRESIFCIQYN--VRAFMNVKHWPWMKLYFKIKPLLK 845
Query: 347 KSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN 406
+ MA+ + EE + + KT A E +K+ L E +L L + Q
Sbjct: 846 SAETEKEMANMK-----EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV---QA 897
Query: 407 IDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLA 466
+ D Q++K + ++E K + ++T RA+ EE A A+
Sbjct: 898 EADSLADAEERCDQLIKT------KIQLEAK-----IKEVTERAEDEEEINAELTAKKRK 946
Query: 467 QAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQ 526
++ L+K + + + + EK + + M DE + + + Q
Sbjct: 947 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1006
Query: 527 AKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTY 586
+ T +++A + + + KL ++ E +K+ + L+
Sbjct: 1007 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLA 1066
Query: 587 RLTLQDTEDALSQDQLEQMILTEELQAI--------RQAIQGELELRRKTDAAIREKLQE 638
+ + D E+ + QL++ + +E + QA+ +L+ + K A E+L+E
Sbjct: 1067 QESTMDIEN--DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEE 1124
Query: 639 HMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVEL 698
+ + + ++ + +K+++++ L +I+ + + TS++++ ++K E
Sbjct: 1125 EIEAERASR------AKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEF 1175
Query: 699 DQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKR 758
+ + + E Q E + T L K+ V+EL GE++ L+ ++
Sbjct: 1176 QKMRRDLEE--ATLQHEATAAT------------LRKKHADSVAEL-GEQIDNLQRVKQK 1220
Query: 759 LSKLIDEHDGKAVQAQVTWLRLQQEMV-KVTQEQEEQLASLDASKKELHIMEQKKLR-VE 816
L K + ++ ++ L E V K E+ +L+ E+ E+++ R +
Sbjct: 1221 LEK-----EKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN 1275
Query: 817 SKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENE------FVR 870
Q + Q E + + LD ++ L + ++++E+ R E E
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAH 1335
Query: 871 SLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQ 930
+L++S + ++++ + E KA L + +A ++ W K + I +
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYE---------TDAIQR 1386
Query: 931 TEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTD 990
TE E+ K +L Q L+ E+ + A+ A E + + + + + RT+
Sbjct: 1387 TE------ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTN 1440
Query: 991 FHHKQLELRRKIRD--VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLE 1048
L+ +++ D + + +C +T ELE +Q+ S SL + K+ + E
Sbjct: 1441 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE-SRSLSTELFKIK------NAYE 1493
Query: 1049 ADLTRLGALKRQNLSEIVALQTRLKHL-QAVKEG--RYVFLFRSKQSLVLERQRLDKRLA 1105
L +L LKR+N + LQ + L + + EG R L + K+ + E+ L L
Sbjct: 1494 ESLDQLETLKRENKN----LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALE 1549
Query: 1106 LIATILDRVRDEYPQFQEALHKVSQMIANKL 1136
L+ + + Q L++V + K+
Sbjct: 1550 EAEASLEHEEGKILRIQLELNQVKSEVDRKI 1580
Score = 73.6 bits (179), Expect = 1e-12
Identities = 127/621 (20%), Positives = 250/621 (40%), Gaps = 81/621 (13%)
Query: 544 EEEKNEKLASILNRTETEAT-LLQKLTTQCLT--KQVALQSQFNTYRLTLQDTEDALSQD 600
EE ++EKLA ++ RT+ L ++ Q + ++ Q+N ++
Sbjct: 778 EEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAF--------MNVK 829
Query: 601 QLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKT-TKYFNQLILRLQKE 659
M L +++ + ++ + E E+ + EK +E + + K + ++ L +E
Sbjct: 830 HWPWMKLYFKIKPLLKSAETEKEMANMKEEF--EKTKEELAKTEAKRKELEEKMVTLMQE 887
Query: 660 KTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRR 719
K ++ + +A R D KT ++L+ +K+V E + EI+
Sbjct: 888 KNDLQLQVQAEADSLAD-------AEERCDQLIKTKIQLEAKIKEVTER-AEDEEEINAE 939
Query: 720 TILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLR 779
+RK LE SEL +++ LEL + ++ K + K
Sbjct: 940 LTAKKRK----------LEDECSEL-KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 988
Query: 780 LQQEMVKVTQEQ-------EEQLASLDASKKELHIMEQKKLRVESKI-------EQEKKE 825
L + + K+T+E+ ++ L L A + +++ + + K+++E ++ EQEKK
Sbjct: 989 LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKI 1048
Query: 826 QKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDK 885
+ ++E + L+ DLK S+ ++E + + + + LK E E +Q K
Sbjct: 1049 RMDLERAKRKLEGDLKLAQE-------STMDIENDKQQLDEK----LKKKEFEMSGLQSK 1097
Query: 886 LN-------QLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIR---- 934
+ QL ++ L ++ E E +I A++ RS + E+ + R
Sbjct: 1098 IEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1157
Query: 935 --AMKGEIHRMKVRLGQLLKQQEKMIRA-----MELAVARRETVTTQAEGQRKMDRKALT 987
A +I K R + K + + A A R++ + AE ++D
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1217
Query: 988 RTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTL 1047
+ ++ E++ +I D+ + +K LE+ R + L E + K Q + L
Sbjct: 1218 KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDL 1277
Query: 1048 EADLTRL----GALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKR 1103
A RL G RQ L E L ++L + + L R + + + L
Sbjct: 1278 TAQRARLQTESGEYSRQ-LDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHA 1336
Query: 1104 LALIATILDRVRDEYPQFQEA 1124
L D +R++Y + QEA
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEA 1357
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 100 bits (249), Expect = 8e-21
Identities = 161/842 (19%), Positives = 363/842 (43%), Gaps = 103/842 (12%)
Query: 333 EVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT 392
E+ +L + +L E+ E +QK +E NE+ L+ + T
Sbjct: 1834 EINNYLQQIDQLKER-----IAGLEEEKQKNKEFSQT---------LENEKNTLLSQIST 1879
Query: 393 ---EMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTR 449
E++ L + M ++Q +++++ +T++ + AE E+ E Q + +L
Sbjct: 1880 KDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQ---LAELNGS 1936
Query: 450 AQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRR----IMQQWASSLVG 505
+D+ + + + + L+K VSE E + EK + I +++ + G
Sbjct: 1937 IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQG 1996
Query: 506 MKHR--DEAHRAVL-EALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEA 562
+ +++H L E L+ Q + K + Y++ I E + L + ++ +
Sbjct: 1997 AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDL 2056
Query: 563 TLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGEL 622
+ ++ Q + + Q++ ++++ L DT+ ++ + + L +ELQ+ +++++ ++
Sbjct: 2057 EITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 623 -----ELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQT 677
+L R+ + A + L+E + + + L++ + L+K + ++ Q
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 678 TLDITHTSSRLDAHQKTLVELDQD----VKKVNELITNSQSEISRRTILIERKQGLINFL 733
++ T ++L A K++ L D + + + I + I K+ + L
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 734 NKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQV-TWLRLQQEMVKVTQ-EQ 791
QL +M + EE L++ I RL EHD + +++ T ++LQQ++ Q E
Sbjct: 2237 KDQLRQMSIHM--EE---LKINISRL-----EHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 792 EEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNR 851
+E L+ L+ ++ H + + ++ES E K ++ + DL N L+K
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLES-------ELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
Query: 852 CSSEELE---QNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIM 908
+ E QN++ + + L+AS T ++ +++N ++ +LL+ EA
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEA----- 2394
Query: 909 LWEKKIQLA-KEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAME-LAVA 966
IQ+A E+R D EI + E + E V + K +K + ME L
Sbjct: 2395 -----IQVAIAELRQQHDKEIKELE-NLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI 2448
Query: 967 RRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNV 1026
++E + +A+ +D + + Q + R + D ++ + +LE ++ +
Sbjct: 2449 KKENIQQKAQ----LDSFVKSMSSL---QNDRDRIVGDYQQLEERHLSIILEKDQLIQEA 2501
Query: 1027 SSSLLEKQEKLSVIQADFDTLEADLTRLGA---LKRQNLSEIVALQ-TRLKHLQAVK--- 1079
++ + +E++ +++ D L ++ +L A R++L++++ ++ ++ K L V+
Sbjct: 2502 AAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQ 2561
Query: 1080 ----EGRYV--------------FLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQF 1121
E +Y L RS +L E+Q L K + + + ++ +
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTAL 2621
Query: 1122 QE 1123
QE
Sbjct: 2622 QE 2623
Score = 90.9 bits (224), Expect = 6e-18
Identities = 206/1117 (18%), Positives = 442/1117 (39%), Gaps = 223/1117 (19%)
Query: 206 LSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQDQIQQPSTEEGAMAERVESE 265
+SH +++ + L++ + + G+ H RE L D++Q+ +++ + +
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLE--HLRE--LQPKLDELQKLISKKEEDVSYLSGQ 1414
Query: 266 GSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQ 325
S++EA Q +++ + + AL L Q ++ +++L V + + + +
Sbjct: 1415 LSEKEAALTKIQTEIIEQEDLIK-----ALHTQLEMQAKEHDERIKQLQVELCEMKQKPE 1469
Query: 326 ELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERK 385
E+G QQ +Q+ L+ + A E + +EEL AR + + +
Sbjct: 1470 EIGEESRAKQQ----IQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1525
Query: 386 KLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKA-ETERIRAEIEKKKQDLYVD 444
+++A E + + L +Q + RD +++T++ + E + + + E K L ++
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQ----EERD--KLITEMDRSLLENQSLSSSCESLK--LALE 1577
Query: 445 QLTTRAQQLEEDIALFEAQYLAQA----EDTRILRKAVSEACTEIDAISVEKRRI----- 495
LT ++L ++I ++ +A++ E + L+K + +S E RI
Sbjct: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE 1637
Query: 496 -MQQWASSLVGMKHRDEAHRAVLEA-LRGCQHQAKSTDGEIEAYKKS----IMKEEEKNE 549
++Q L G EA++ E L+ + + + ++ + KS I++ EE+N+
Sbjct: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
Query: 550 KL-ASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILT 608
+L A + +T ++ L L+ +++ + ++ + E+ L+
Sbjct: 1698 RLRAEVHPAGDTAKECMETL----LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753
Query: 609 EELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKT----------------------- 645
EE+Q ++ I+G + + +A + Q ++T T
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813
Query: 646 ----TKYFNQLILRLQKEKTNMMTHLSKI----------------NGDIAQTTLDITHT- 684
K N + + + +L +I N + +QT + +T
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL 1873
Query: 685 SSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSEL 744
S++ L L ++V K+N L Q E+SR T L E + + L ++L ++EL
Sbjct: 1874 LSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAEL 1933
Query: 745 GGEEVGP--------------LELEIKRLSKLIDEHDGKAVQAQVTWLRLQ--------- 781
G +G LE E+K L K + E + + Q +++
Sbjct: 1934 NG-SIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
Query: 782 ------------------QEMVKVTQEQ-----------EEQLASLDASKKELHIME--- 809
QE++K Q++ +E++++L+ + K L ++
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
Query: 810 QKKLRVESK-----IEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNN--- 861
QK L + + +E KK Q E+ LD+ + ++ N +EL+ N
Sbjct: 2053 QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112
Query: 862 ----RVTENEFVRSLKASERETIK----MQDKLNQLSEEKATLLNQLVEAEHQIMLWEKK 913
+ + + R L+ +E + +K MQ+KL+ L EK L + E + + +K+
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE 2172
Query: 914 IQLAKEMRSSVDSEIG----------------------------------QTEIR----- 934
+Q +E S +++ + EIR
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDN 2232
Query: 935 --AMKGEIHRMKVRLGQLL---------KQQEKMIRAMELAVARRETVTTQAEGQRKMDR 983
+K ++ +M + + +L KQ + E+ + ++ T Q E + + +
Sbjct: 2233 CSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQ 2292
Query: 984 KALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELE---ETQRNVSSSLLEKQEKLSVI 1040
TR +H Q EL + +++ D+ T LE E + N+ + +++ +
Sbjct: 2293 LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
Query: 1041 QADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLE-RQR 1099
+ ++ LE DL L + EI + ++ L + KE + Q + E RQ+
Sbjct: 2353 KFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE-------EAIQVAIAELRQQ 2405
Query: 1100 LDKRLALIATILDRVRDEYPQFQE----ALHKVSQMI 1132
DK + + +L + +E +E A+ K +Q++
Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLM 2442
Score = 88.6 bits (218), Expect = 3e-17
Identities = 177/957 (18%), Positives = 390/957 (40%), Gaps = 134/957 (14%)
Query: 245 QDQIQQPSTEEGAMAERVESEGSDEEAEDEG---SQLVVLDPDHPLMVRFQAALKNYLNR 301
Q Q+Q +E AERV S E + +L + D L+ + + L +
Sbjct: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV--ETLQQ 894
Query: 302 QIEKLKLDLQELVVATKQSRAQRQE----LGVNLYEVQQHLVHLQKLLEKSHDR---HAM 354
IE+ + E+ + + Q E LGV + +++ L L + E ++
Sbjct: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
Query: 355 ASSERRQKEEELQAARALYTKTCA-------AANEERKKLAALQTEMENLALHLFYMQNI 407
SS +Q +E+ A + + NE+RK+ LQ + N L + +
Sbjct: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVSRL 1012
Query: 408 DQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQ 467
++++ + + + +ETER E +K+ ++ +T++ Q++E ++ Q +++
Sbjct: 1013 EEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIE----IYLKQTISE 1068
Query: 468 AE-DTRILRKAVSE---ACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGC 523
E + + +RK + E A + A+ + + +Q + + ++ ++A+++ L
Sbjct: 1069 KEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--I 1126
Query: 524 QHQAKSTDGEIEAYKKSIM--------KEEEKNEKLASILNRTETEATLLQKLTTQCLTK 575
++DG+ A K + E +L + E E LQK + LT
Sbjct: 1127 TSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTS 1186
Query: 576 QVA---------------LQSQFNTY-RLTLQDTEDALSQDQLEQMILTEELQAIRQAIQ 619
+ A L+ Q + Y RL Q E + + + + ++Q +R++I
Sbjct: 1187 RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ-VRESID 1245
Query: 620 GELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQ--------KEKTNMM---THLS 668
G+L + ++ E T ++ Q +L E + + T ++
Sbjct: 1246 GKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVA 1305
Query: 669 KINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQG 728
+I + + + ++ + L + ++V ++ E I EI + +
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
Query: 729 LINFLNKQLERMVSELGG-EEVGPLELEIKRLSKLIDEHD-------GKAVQAQVTWLRL 780
L ++LE ++ G E + L+ ++ L KLI + + G+ + + ++
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 781 QQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDL 840
Q E++ EQE+ + +L +E + + +I+Q + E E++ +++ +
Sbjct: 1426 QTEII----EQEDLIKALHTQ------LEMQAKEHDERIKQLQVELCEMKQKPEEIGEES 1475
Query: 841 KKLNMLMNKNRC---SSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLS---EEKA 894
+ + K + S +E + N+ + E + ER T + D +Q+S +EK
Sbjct: 1476 RAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKD 1535
Query: 895 TLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQ 954
T+L +L +L E++ +L EM S+ E +++ +K+ L L + +
Sbjct: 1536 TVLGRLA------LLQEERDKLITEMDRSL------LENQSLSSSCESLKLALEGLTEDK 1583
Query: 955 EKMIRAME-------------------------LAVARRETVTTQAEG-QRKMDRKALTR 988
EK+++ +E + + E V+ +AE Q ++ +
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643
Query: 989 TDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLE 1048
+ + K ++ K E + + E++E R + S KQ+K+ ++ + D L
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLR 1700
Query: 1049 ADLTRLGALKRQNLSEIVALQTRLKH-LQAVKEGRYVFLFRSKQSLVLERQRLDKRL 1104
A++ G ++ + +++ +K L+ VK Y L + QSL+ E+ L + +
Sbjct: 1701 AEVHPAGDTAKECMETLLSSNASMKEELERVKM-EYETLSKKFQSLMSEKDSLSEEV 1756
Score = 79.7 bits (195), Expect = 1e-14
Identities = 185/951 (19%), Positives = 379/951 (39%), Gaps = 191/951 (20%)
Query: 333 EVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT 392
+VQ+ L + ++L+ + D + +QK+E LQ EERK A
Sbjct: 49 DVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ--------------EERK---AADN 91
Query: 393 EMENLALH----LFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTT 448
+++ L LH L + ++M+ + ++E + + + ++++ ++++
Sbjct: 92 KIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH 151
Query: 449 RAQQLEEDIALFEAQYL-AQAEDTRILRKAVSEACTEIDAISVEKRRIM--QQWASSLVG 505
+ Q+ EE I+ +AQ AQAE +++ TE++ + K+++ +++ S+L
Sbjct: 152 KLQEKEELISTLQAQLTQAQAEQP-------AQSSTEMEEFVMMKQQLQEKEEFISTLQA 204
Query: 506 MKHRDEAHRAVLEALRGCQHQAKS---------------TDGEIEAYKKSIMKEEEKNEK 550
+ +A +A + +R + ++ D E E +K + + + E
Sbjct: 205 QLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEH 264
Query: 551 LASILNRTETEATLLQKLT-----TQCLTKQV-ALQSQFNTYRLTLQDTEDALSQDQLEQ 604
S++ R + L Q+LT Q L++Q+ ++++ NT R T+ +TE S+ LE+
Sbjct: 265 EESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTV-ETEREESKILLEK 323
Query: 605 M------------ILTEE----LQAIRQAIQGELE-------LRRKTDAAIREKLQEHMT 641
M L EE L+ QA Q + E L +K A + EK ++
Sbjct: 324 MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
Query: 642 SNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQD 701
KT + L+ + + ++ ++ AQT + D Q+ E+ Q
Sbjct: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE------DQLQQKSKEISQF 437
Query: 702 VKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSK 761
+ ++ + S+ S + E Q + L++ V EL E+ G L L L +
Sbjct: 438 LNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK-GALLLSSIELEE 496
Query: 762 LIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQ 821
L E++ + +Q+T L Q + +E E A+K+ E + +E+ Q
Sbjct: 497 LKAENE--KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQ 554
Query: 822 EKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIK 881
+ KE + MK+ ++ L + + R E ++ V + + ++ ++ IK
Sbjct: 555 KHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE----EADHEVLDQKEMKQMEGEGIAPIK 610
Query: 882 MQDKLNQLSEEKATLLN----------QLVEAEHQ------IMLWEKKIQLAKEMRS--- 922
M+ L ++ + N + EHQ I L + ++L +
Sbjct: 611 MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670
Query: 923 --SVDSEIG---QTEIRAMKGEIHRMKV---------------------RLGQLLKQQEK 956
S +IG Q E+ +K +I +++ L QL+++ +K
Sbjct: 671 SLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK 730
Query: 957 ---------------------------MIRAMELAVARRETVTTQAEGQRKMDRKALTRT 989
M+ + V + E +AE QR++D ++ T
Sbjct: 731 NADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAH 790
Query: 990 D------FHHKQLE----------LRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEK 1033
D H +E L+ ++ DV+ E + + L+ +N S +LE
Sbjct: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
Query: 1034 QEKLSVIQADFDTL-------EADLTRLGALKRQNLSEIVALQTRLKHL-QAVKE----- 1080
E++ I + + L E ++T++ L + ++ LQ ++ Q V E
Sbjct: 851 AERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSM 910
Query: 1081 -GRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQ 1130
+ V L K SL +E + L ++L L++ + +++ + E + Q
Sbjct: 911 TEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ 961
Score = 77.4 bits (189), Expect = 7e-14
Identities = 165/915 (18%), Positives = 361/915 (39%), Gaps = 115/915 (12%)
Query: 237 REGDLPVFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALK 296
+E + V +DQ++Q S + + D++ + +Q V + Q +
Sbjct: 2229 KEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV---------QLQQKVC 2279
Query: 297 NYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMAS 356
+ L + ++L L+E S+ + +L L ++ L L LEK ++
Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
Query: 357 SERRQKEEE--------------LQAARALYTKTCAAANEERKKLAALQTEMENLALHLF 402
RQ+E + LQA+R L ++ N + +K+ +L + E A+ +
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEE-AIQV- 2397
Query: 403 YMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEA 462
+ + Q +I+ + ++ + E E I E E KK + QL E + +
Sbjct: 2398 AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK-------AVDKTNQLMETLKTIKK 2450
Query: 463 QYLAQAEDTRILRKAVSEACTEID--------------AISVEKRRIMQQWASSLVGMKH 508
+ + Q K++S + D +I +EK +++Q+ A+ +K
Sbjct: 2451 ENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE 2510
Query: 509 RDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSI-----MKEEEKNEKLASILNRTETEAT 563
R+ ++ L + D E+ Y++ + +K+ ++ + L L + +
Sbjct: 2511 EIRGLRSHMDDLNS---ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 564 LLQKLTTQCLTKQVA---LQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQG 620
KL + + A L+ FN + QD + ++ LT ++ A+++ +G
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQE--EG 2625
Query: 621 ELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLD 680
L L A ++ K +E + + I L++E + +K G+I
Sbjct: 2626 TLGLYH---AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE----- 2677
Query: 681 ITHTSSRLDAHQKTLVELDQD---VKKVNELITNSQSEISRRTILIERKQGLINFLNKQL 737
D +K L L D ++ E +E++R + +E+K ++ NK L
Sbjct: 2678 --------DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729
Query: 738 ERMVSELG-------------GEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEM 784
+ G EE+ L+ + K + + + + + L +
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789
Query: 785 VKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLN 844
+ +E L+ L+ ++L +++ L + S++E + + M L N+ L
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849
Query: 845 MLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAE 904
+ K R SEE +Q + + +++ ++ +Q+ ++L +E L Q ++
Sbjct: 2850 NELEKFR-KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQIN 2908
Query: 905 HQIM-LWEKKIQLAKEMRSSVDSEIGQTEIR----AMKGEIHRMKVRLGQLLKQQEKMIR 959
+I L K QL + + +I Q E+R + + E+H++++ + +M
Sbjct: 2909 QEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKE 2968
Query: 960 AMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLEL 1019
+A++ ++ + + + R + ++T Q + R+ + + D V E
Sbjct: 2969 QYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ-RQASPETSASPDGSQNLVYET 3027
Query: 1020 EETQRNVSSSLLE---KQEKLSVIQADF-------DTLEADLTRLGALKRQN-------L 1062
E + ++ SL E K+ ++ + ++F +TL L R+N L
Sbjct: 3028 ELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLL 3087
Query: 1063 SEIVALQTRLKHLQA 1077
+ L+ +++ LQA
Sbjct: 3088 NHCAVLEKQVQELQA 3102
Score = 76.3 bits (186), Expect = 2e-13
Identities = 184/963 (19%), Positives = 384/963 (39%), Gaps = 163/963 (16%)
Query: 243 VFQDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPD---HPLMVRFQAALKNYL 299
+ Q+QQ E + VE+E + + E +L V + H L L+ +
Sbjct: 291 ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF- 349
Query: 300 NRQIEKLKLDLQELVVATKQS-RAQRQELGVNLYEVQQHLVHLQ-----------KLLEK 347
Q + + +L+ A +Q +A+ +E ++ +Q+ LQ KLL+
Sbjct: 350 -EQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQD 408
Query: 348 SHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT--EMENLALHLFYMQ 405
+++ ++ +Q E++LQ ++ ++ + A+ + ++ N +
Sbjct: 409 KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEE 468
Query: 406 NIDQDMRDDIRVMTQ----VVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFE 461
NI + + + + ++ E E ++AE EK + + + R + + +++
Sbjct: 469 NIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEIS 528
Query: 462 AQYLA-----QAEDT--RILRKAVSEACTEIDAISVEKRRIMQQWASSLVGM--KHRDEA 512
+A AE++ +L S+ E+ + +E + ++ A + + K +EA
Sbjct: 529 IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA 588
Query: 513 HRAVLEALRGCQHQAKSTDGE-IEAYKKSIMKEEE-------KNEKLASILNRTETEATL 564
VL+ Q + K +GE I K + E+ NE+ + E +T
Sbjct: 589 DHEVLD-----QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
Query: 565 LQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALS---------QDQLEQM---ILTEEL- 611
Q T++ +++L + T QD + +LS QD+LE++ IL EL
Sbjct: 644 HQSRTSE----EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
Query: 612 -QAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTH---- 666
++ + L+ + K + + + ++E K + L +E+ +++
Sbjct: 700 FHKAQEIYEKNLDEKAKEISNLNQLIEEF---KKNADNNSSAFTALSEERDQLLSQVKEL 756
Query: 667 --LSKINGDIAQTTLDITHT--SSRLD-----AHQKTLVE----LDQDVKKVNELITNSQ 713
++++ + Q +++ RLD AH L E L + K + I Q
Sbjct: 757 SMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQ 816
Query: 714 SEISRRTILIERKQGLINFLNKQLERMVSEL--GGEEVGPL--------------ELEIK 757
+E+ + + LI L QL+ SE+ G E V + ELEI
Sbjct: 817 NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEIT 876
Query: 758 RLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHI---MEQKKLR 814
++ +L+ E Q T Q++ +++ E++ L+ K L + +++L
Sbjct: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLN 936
Query: 815 VESKIEQEKKEQKEIEHHMKDLDNDLKK-LNMLMNKNRCSSEELEQNNRVTENEFVRSLK 873
+ S+ E+ KKEQ E ++ ++ + LK+ + + + S EEL+ + + E + +
Sbjct: 937 LLSRAEEAKKEQVEEDN---EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993
Query: 874 ASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEK---KIQLAKEMR----SSVDS 926
+ I ++ L ++S + L N E++ +I L E +++ KE + V S
Sbjct: 994 KLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTS 1053
Query: 927 EIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAME--LAVARRETVTTQ---------- 974
+ + EI +K I +V L + K E+ + A E A+ ++ T Q
Sbjct: 1054 KCQEIEI-YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQ 1112
Query: 975 ---AEGQRKMDRKALTRTD-----------------------FHHKQLELRRKIRDVRKA 1008
+E Q + + + TD H + EL KI + K
Sbjct: 1113 AEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKE 1172
Query: 1009 TDECTKTVLE-----------LEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGAL 1057
++ K + E +E +R++ L ++++ + +Q FD + +G
Sbjct: 1173 KEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ 1232
Query: 1058 KRQ 1060
RQ
Sbjct: 1233 LRQ 1235
Score = 72.4 bits (176), Expect = 2e-12
Identities = 150/816 (18%), Positives = 326/816 (39%), Gaps = 93/816 (11%)
Query: 325 QELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANEER 384
+ L + E++ + Q++ EK+ D A S Q EE + + A +EER
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 385 KKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVD 444
+L + E+ + ++R ++ + + +AE +R ++ + Q + +
Sbjct: 747 DQLLSQVKELSMVT-----------ELRAQVKQLEMNLAEAERQR---RLDYESQTAHDN 792
Query: 445 QLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLV 504
LT + L + + + + ++ SE T I ++ + + +
Sbjct: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
Query: 505 GMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSI----MKEEEKNEKLASILNRTET 560
++H + +AL + + D + K+ + EEK++++ I
Sbjct: 853 RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE 912
Query: 561 EATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEEL-------QA 613
+ L + + L+ Q N + ++ + +D L + Q
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQI 972
Query: 614 IRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSK---- 669
++ +Q E +L +K + + KLQ + + K Q + RL++E N+ K
Sbjct: 973 SKEELQHEFDLLKKENEQRKRKLQAALINRKE---LLQRVSRLEEELANLKDESKKEIPL 1029
Query: 670 ---INGDIAQTTLDITHTSSRLDAH-QKTLVELDQDVKKVNELITNSQSEISRRTILIER 725
G++ + + ++ + + Q+ + L Q + + + + + ++ + E+
Sbjct: 1030 SETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
Query: 726 KQGLINFLNKQLERMVSELG--GEEVGPLELEIKRL-SKLIDEHDGKAVQAQVTWLRLQQ 782
Q L+ +N+ L+ +++ E+ + I++L + D DG +V + +
Sbjct: 1090 FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISP 1149
Query: 783 EMVKVTQ----EQEEQLASLDASKKELHIMEQKKLR--VESKIEQEKKEQKEIEHHMKDL 836
++ E EE++ +L+ K++L QKKL+ + S+ KK Q++ H ++L
Sbjct: 1150 PCTGSSEHWKPELEEKILALEKEKEQL----QKKLQEALTSRKAILKKAQEKERHLREEL 1205
Query: 837 DNDLKKLNMLMNKNRCSSEELEQNNRVTEN--EFVRSLKASERETIKMQDKLNQLSEEKA 894
N L E+ ++ ++ EN + +R L+ RE+I KL ++++
Sbjct: 1206 KQQKDDYNRL-------QEQFDEQSKENENIGDQLRQLQIQVRESI--DGKLPSTDQQES 1256
Query: 895 TL--------LNQLVEAEHQIMLWEKKI----QLAKEMRSSVDSEIGQTEIRAMKGEIHR 942
L + E H + E + E S++ +I+A EI
Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 943 MKVRL--------GQLLKQQEKMIRAME------LAVARRETVTTQAEGQRKMDRKALTR 988
KV L +L K+ E++ + E L + +TV+ +AE + ++ L
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376
Query: 989 TDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADF---- 1044
+ LE +R+++ DE K + + EE +S L EK+ L+ IQ +
Sbjct: 1377 SQLQIAGLE---HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQE 1433
Query: 1045 DTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKE 1080
D ++A T+L +++ I LQ L ++ E
Sbjct: 1434 DLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE 1469
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 100 bits (249), Expect = 8e-21
Identities = 181/917 (19%), Positives = 364/917 (39%), Gaps = 118/917 (12%)
Query: 198 MGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQDQIQQPSTEEGA 257
+G Q + +G +I + L +F S + V+ + QDQ Q+ + E +
Sbjct: 336 VGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAE----------HQDQGQEVNGEVRS 385
Query: 258 MAERVESEGSDEE--AEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVV 315
+ + S S E AE + L VL L + +A EK +L Q +
Sbjct: 386 RRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAAL 445
Query: 316 ATK--------QSRAQRQE--------LGVNLYEVQQHLVHLQKLLEKSHDRHAMASSER 359
+TK S QRQ+ L + +++++ + LQ +LE + A ++++
Sbjct: 446 STKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDL 505
Query: 360 RQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMT 419
+ EE+ Q L ++E++ + N D+R + +
Sbjct: 506 QVAEEQYQR---------------------LMAKVEDMQRSMLSKDNTVHDLRQQMTALQ 544
Query: 420 QVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALF-EAQYLAQAEDTRILRKAV 478
+++ + ER + K + L + Q ++ +AL EA+ Q E I +
Sbjct: 545 SQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQM 604
Query: 479 SEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYK 538
++A ++ + +E + QQ L +HR + + A Q + + ++ +
Sbjct: 605 TQAGL-LEHLKLENVSLSQQ----LTETQHRSMKEKGRIAA------QLQGIEADMLDQE 653
Query: 539 KSIMKEEEKN----EKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTE 594
+ M+ +E E L L E E LQ++ +L+ Q +LTL +
Sbjct: 654 AAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSA----ASLEQQLEQVKLTLLQRD 709
Query: 595 ---DALSQDQLE---QMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKY 648
+AL Q+ L+ Q+ LT+E R+ L+ A +LQ S + T
Sbjct: 710 QQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDT-- 767
Query: 649 FNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNEL 708
I LQ EK + L LD + L++ ++ +E
Sbjct: 768 ----ICLLQNEKIILEAALQAAKSG-----------KEELDRGAR---RLEEGTEETSET 809
Query: 709 ITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSK--LIDEH 766
+ + E++ ++ +E Q L KQ++++ + ++V SK LI E
Sbjct: 810 LEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISEL 869
Query: 767 DGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQ 826
+ L+QE+++V E+ A L +E+ + Q +E ++ +KE+
Sbjct: 870 KATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKER 929
Query: 827 KEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKL 886
E+E H++ L D +++ + N +++E+ + + KA + KM+
Sbjct: 930 DEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQ-------EARKAITEQKQKMRRLG 982
Query: 887 NQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVR 946
+ L+ + + + E+ + + +++Q A + + D+E+GQ +RA G +
Sbjct: 983 SDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQ--LRAQGGS-SDSSLA 1039
Query: 947 LGQLLKQQEKMIRAME-----LAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRK 1001
L + ++ E ++A+ L +E + ++ + K L D + R+K
Sbjct: 1040 LHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK 1099
Query: 1002 IRDVRKATDECTKTVLELEETQ---RNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALK 1058
I+ + ++ K LELE + + S +E S+++ EADL +L
Sbjct: 1100 IKRLEESN---KKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQV 1156
Query: 1059 RQNLSEIVALQTRLKHL 1075
+ L ++KHL
Sbjct: 1157 QAVLQRKEEEDRQMKHL 1173
Score = 84.0 bits (206), Expect = 8e-16
Identities = 140/722 (19%), Positives = 286/722 (39%), Gaps = 82/722 (11%)
Query: 247 QIQQPST--EEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIE 304
QIQ+ T EE E EG E + L+ V+ ++ ++
Sbjct: 658 QIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLE-QVKLTLLQRDQQLEALQ 716
Query: 305 KLKLDLQELVVATKQSRAQRQE----LGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERR 360
+ LDL + + T+++ R++ L + E+Q L LQ D + +E+
Sbjct: 717 QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
Query: 361 QKEEELQAARA-----------------LYTKTCAAANEE-----------RKKLAALQT 392
E LQAA++ ++T EE +++ AAL+
Sbjct: 777 ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKK 836
Query: 393 EMENLALHLFYMQNIDQDMRDDIRVMTQVVK--KAETERIRAEIEKKKQDL---YVDQLT 447
+M+ + + + + R D Q++ KA +R+ +E+++ +Q+L + ++ T
Sbjct: 837 QMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRT 896
Query: 448 TRAQ--QLEEDIALFEAQYLAQAED-TRILRKAVSEACTEIDAISVEKRRIMQQWASSLV 504
A+ +L ++A Q++A E + +K E T + ++ +K +++ ++
Sbjct: 897 AEAELSRLHREVAQVR-QHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEA 955
Query: 505 GMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATL 564
K +E + +A+ + + + ++ + +K + + + E IL+R EA L
Sbjct: 956 LKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA-L 1014
Query: 565 LQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQD----QLEQMILTEELQAIRQAIQG 620
K Q+ Q + L L + AL + + +L +ELQ +
Sbjct: 1015 AAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQ 1074
Query: 621 ELELRRKTDAAIREKLQEHMTSNKTTKYFNQ----LILRLQKEKTNMM----------TH 666
ELE R+ + ++LQE K K + L L L+ EK + H
Sbjct: 1075 ELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH 1134
Query: 667 LSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERK 726
S + +A+ D+ + ++ A + E D+ +K + + + S +E++
Sbjct: 1135 NSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQAS----------LEKE 1184
Query: 727 QGLINFLNKQLERMVSELGGE---------EVGPLELEIKRLSKLIDEHDGKAVQAQVTW 777
+ +N L +Q+ E G E+ ++ E++ L+ + +A Q+
Sbjct: 1185 KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE 1244
Query: 778 LRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLD 837
+ QE+ + E E A L +K+L K+ ++E K E + E ++ L
Sbjct: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
Query: 838 NDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLL 897
L K ++L QN + L ++++ +Q K+++L TLL
Sbjct: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLL 1364
Query: 898 NQ 899
Q
Sbjct: 1365 QQ 1366
Score = 60.8 bits (146), Expect = 7e-09
Identities = 73/340 (21%), Positives = 148/340 (43%), Gaps = 37/340 (10%)
Query: 771 VQAQVTWLRLQ-QEMVKVTQEQEEQLASLD----ASKKELHIMEQKKLRVESKIEQEKKE 825
++ Q+ L L+ + +K E + QLA+L A + H +Q++ + S+++ K+
Sbjct: 417 LEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQS 476
Query: 826 QKEIEHHMKDLDNDLKKLNMLM---NKNRCSSEELEQNNRVTENEFVRSLKASE------ 876
++E M DL N L+ N + N + +EE Q + RS+ + +
Sbjct: 477 CWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDL 536
Query: 877 -RETIKMQDKLNQLSEEKATLLNQLVEAEHQI-------MLWEKKIQLAKEMRSSVDSEI 928
++ +Q +L Q+ E+ TL ++L ++ +I +++++ LA+E R + E+
Sbjct: 537 RQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEM 596
Query: 929 GQTEIRAMK--GEIHRMK---VRLGQLLKQ------QEKMIRAMELAVARRETVTTQAEG 977
++ M G + +K V L Q L + +EK A +L + + +A
Sbjct: 597 AHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAF 656
Query: 978 QRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKL 1037
+ + K + D + E + +++ D +LE+ V +LL++ ++L
Sbjct: 657 MQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQ----VKLTLLQRDQQL 712
Query: 1038 SVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQA 1077
+Q + L LT + + ALQT LQA
Sbjct: 713 EALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQA 752
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 99.8 bits (247), Expect = 1e-20
Identities = 153/817 (18%), Positives = 354/817 (43%), Gaps = 92/817 (11%)
Query: 263 ESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRA 322
E ++ + ++ ++ LD + + + AL+ + ++ L+++ ++ TK
Sbjct: 971 EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKT- 1029
Query: 323 QRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAANE 382
+++Q + L+ LE+ +R+ E +L+ A+ T +
Sbjct: 1030 ----------KLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ 1079
Query: 383 ERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETE-----RIRAEIEKK 437
+KL + EM NL + Q + ++ I+ + +++ E E RA+ EK+
Sbjct: 1080 LNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 438 KQDLYVDQLTTRAQQLEE----DIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKR 493
+ DL +L +++LEE A E +AE + +R+ + E+ + +A + R
Sbjct: 1140 RSDLS-RELEEISERLEEAGGATSAQIEMNKKREAEFQK-MRRDLEESTLQHEATAAALR 1197
Query: 494 RIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLAS 553
+ + A S+ + + ++ + V + L + + K ++ + +++ K + EK+
Sbjct: 1198 K---KHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCR 1254
Query: 554 IL----NRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTE 609
L + +T+ Q+L + ++ L ++ + L + + +SQ + T+
Sbjct: 1255 TLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQ 1314
Query: 610 ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSK 669
+++ +++ + E E + K+ A + H +Y + Q+ K + +SK
Sbjct: 1315 QIEELKRQL--EEETKAKSTLAHALQSARHDCDLLREQYEEE-----QEAKAELQRGMSK 1367
Query: 670 INGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEI----SRRTILIER 725
N ++AQ T DA Q+T EL++ KK+ + + +++ + S+ L +
Sbjct: 1368 ANSEVAQW-----RTKYETDAIQRT-EELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 726 KQGLINFLNKQLERMVSELGGEEVGPLELEIKR--LSKLIDEHDGKAVQAQVTWLRLQQE 783
KQ L N ++E ++ ++ + L+ K+ K++ E K + Q Q+E
Sbjct: 1422 KQRLQN----EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE 1477
Query: 784 -------MVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDL 836
+ KV EE L L+ K+E ++Q+ + +I + K E+E K L
Sbjct: 1478 SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQL 1537
Query: 837 DNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATL 896
D++ +L + S EE E SL+ E + +++Q +LNQ+ K+ +
Sbjct: 1538 DHEKSEL-------QTSLEEAE-----------ASLEHEEGKILRIQLELNQV---KSEI 1576
Query: 897 LNQLVEAEHQI-MLWEKKIQLAKEMRSSVDSEIGQTE-----IRAMKGEIHRMKVRLGQL 950
++ E + ++ L +++ + M+S++D+EI + M+G+++ M+++L
Sbjct: 1577 DRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHA 1636
Query: 951 LKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATD 1010
+Q + +R + R T + Q +D + D + + R+ ++ +
Sbjct: 1637 NRQAAEALRNL------RNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVE 1690
Query: 1011 ECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTL 1047
E ++ E ++ LL+ E++ ++ +L
Sbjct: 1691 ELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727
Score = 95.1 bits (235), Expect = 3e-19
Identities = 157/864 (18%), Positives = 352/864 (40%), Gaps = 75/864 (8%)
Query: 287 LMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLE 346
L+ R QA + +L R + ++ +E + + + R + V + + ++ LL+
Sbjct: 788 LITRTQAICRGFLMRVEFRKMMERRESIFCIQYNI--RAFMNVKHWPWMKLYFKIKPLLK 845
Query: 347 KSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYM-- 404
+ MA+ + EE + + KT A E +K+ L E +L L +
Sbjct: 846 SAETEKEMANMK-----EEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900
Query: 405 ------QNIDQDMRDDIRV---MTQVVKKAETER-IRAEIEKKKQDLYVD--QLTTRAQQ 452
+ DQ ++ I++ + +V ++AE E I AE+ KK+ L + +L
Sbjct: 901 ALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 960
Query: 453 LEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEA 512
LE +A E + A + L + ++ I ++ EK+ + + +L ++ ++
Sbjct: 961 LELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDK 1020
Query: 513 HRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQC 572
+ +A + Q +G +E KK M E KL L + E+T+ + Q
Sbjct: 1021 VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQ-ESTMDTENDKQQ 1079
Query: 573 LTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRR------ 626
L +++ + +F L + ++ QL++ I +ELQA + ++ E+E R
Sbjct: 1080 LNEKLK-KKEFEMSNLQGKIEDEQALAIQLQKKI--KELQARIEELEEEIEAERASRAKA 1136
Query: 627 -KTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTS 685
K + + +L+E + + + K++ K+ D+ ++TL T+
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE---AEFQKMRRDLEESTLQHEATA 1193
Query: 686 SRL-DAHQKTLVELDQDV---KKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMV 741
+ L H ++ EL + + ++V + + +SE+ + ++ E+M
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMC 1253
Query: 742 SELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDAS 801
L +++ ++ + + +LI+E + RL E + +++ +E+ A +
Sbjct: 1254 RTLE-DQLSEIKTKEEEQQRLINELSAQKA-------RLHTESGEFSRQLDEKDAMVSQL 1305
Query: 802 KKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNN 861
+ Q+ ++ ++E+E K + + H ++ +D L + + + EL++
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 862 RVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMR 921
+E + E + I+ + +L E K L +L +AE + K ++ +
Sbjct: 1366 SKANSEVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTK 1422
Query: 922 SSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKM 981
+ +E+ I ++ R L K+Q + + + E + E +K
Sbjct: 1423 QRLQNEVEDLMI-----DVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE 1477
Query: 982 DRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQ 1041
R T ++ V+ A +E + L+ +N+ + + E+++
Sbjct: 1478 SRSLST-------------ELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGG 1524
Query: 1042 ADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLD 1101
LE +K+Q E LQT L+ +A E + R + L + +D
Sbjct: 1525 KHIHELEK-------VKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEID 1577
Query: 1102 KRLALIATILDRVRDEYPQFQEAL 1125
+++A LD+++ + + E++
Sbjct: 1578 RKIAEKDEELDQLKRNHLRVVESM 1601
Score = 89.0 bits (219), Expect = 2e-17
Identities = 134/654 (20%), Positives = 286/654 (43%), Gaps = 73/654 (11%)
Query: 538 KKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDAL 597
+K + +E+ EK L +TE + L++ K V L + N +L +Q DAL
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEE-------KMVTLMQEKNDLQLQVQAEADAL 902
Query: 598 --SQDQLEQMILTE-----ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFN 650
++++ +Q+I T+ +++ + + + E E+ + A R+ E K
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 651 QLILRLQKEK---TNMMTHLSKINGDIAQTTLDITHTSSRL-DAHQKTLVELDQDVKKVN 706
+ +++KEK N + +L++ + +T +T L +AHQ+TL +L + KVN
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVN 1022
Query: 707 ELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEH 766
L T +++++ ++ +E L LER +L G +L++ + S + E+
Sbjct: 1023 TL-TKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG------DLKLAQESTMDTEN 1075
Query: 767 DGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQ 826
D + + ++ + + EM + + E++ A +K++ ++ + +E +IE E+ +
Sbjct: 1076 DKQQLNEKLK--KKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASR 1133
Query: 827 KEIEHHMKDLDNDLKKLN-MLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDK 885
+ E DL +L++++ L +S ++E N + E EF + + E T++ +
Sbjct: 1134 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK-REAEFQKMRRDLEESTLQHEAT 1192
Query: 886 LNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAK-EMRSSVDSEIGQTE-IRAMKGEIHRM 943
L ++ A + +L E + ++K++ K E++ ++ E + K +M
Sbjct: 1193 AAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252
Query: 944 KVRLGQLL-----KQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLEL 998
L L K++E+ EL+ + T E R++D K + +
Sbjct: 1253 CRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAF 1312
Query: 999 RRKIRDVRKATDECTK---TVLELEETQRNVSSSLLEKQEKLSVIQADFD---------- 1045
++I ++++ +E TK T+ ++ R+ L E+ E+ +A+
Sbjct: 1313 TQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372
Query: 1046 -----TLEAD-LTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQ-------S 1092
E D + R L+ LQ +H++AV + L ++KQ
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV-NSKCASLEKTKQRLQNEVED 1431
Query: 1093 LVLERQR-------LDKRLALIATILDRVRDEYPQFQ---EALHKVSQMIANKL 1136
L+++ +R LDK+ +L + +Y + Q EA K S+ ++ +L
Sbjct: 1432 LMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTEL 1485
Score = 64.7 bits (156), Expect = 5e-10
Identities = 143/730 (19%), Positives = 294/730 (40%), Gaps = 122/730 (16%)
Query: 272 EDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNL 331
ED+ S++ + + ++ +A K L+ + + L E Q +Q +
Sbjct: 1257 EDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQI 1316
Query: 332 YEVQQHLVHLQKLLEKSHDRHAMASSER-----RQKEEELQAARALYTKTCAAANEERKK 386
E+++ L K KS HA+ S+ R++ EE Q A+A + + AN E
Sbjct: 1317 EELKRQLEEETKA--KSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE--- 1371
Query: 387 LAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDL--YVD 444
+A +T+ E A+ + E E + ++ ++ QD +V+
Sbjct: 1372 VAQWRTKYETDAIQ----------------------RTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 445 QLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLV 504
+ ++ LE+ + + + ED I + + AC +D +++ +W
Sbjct: 1410 AVNSKCASLEKT----KQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEW----- 1460
Query: 505 GMKHRDEAHRAVLEALRGCQHQAKSTDGEI----EAYKKSI-----MKEEEKNEKLASIL 555
K + E +A LEA Q +++S E+ AY++S+ +K E KN + I
Sbjct: 1461 --KQKYEETQAELEA---SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQ-QEIS 1514
Query: 556 NRTETEAT------LLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTE 609
+ TE A L+K+ Q ++ LQ+ +L+ E + + QLE +
Sbjct: 1515 DLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKS 1574
Query: 610 EL------------QAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQ 657
E+ Q R ++ ++ DA IR + K N++ ++L
Sbjct: 1575 EIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLN 1634
Query: 658 ---KEKTNMMTHLSKINGDIAQTTL--------------DITHTSSRLDAHQKTLVELDQ 700
++ + +L G + T L + R + Q + EL
Sbjct: 1635 HANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRA 1694
Query: 701 DVKKVNELITNSQSEI----SRRTILIERKQGLINFLNKQLERMVSELGGE------EVG 750
+++ ++ E+ R +L + LIN K+LE +S++ GE E
Sbjct: 1695 SLERTERGRKMAEQELLDASERVQLLHTQNTSLIN-TKKKLETDISQIQGEMEDIVQEAR 1753
Query: 751 PLELEIKRL---SKLIDEHDGKAVQAQVTWLRLQQEMVKVTQE------QEEQLASLDAS 801
E + K+ + ++ E K R+++ M + ++ + EQLA L
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA-LKGG 1812
Query: 802 KKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNN 861
KK++ +E + +ES++E E+K E ++ + +K+L ++R + L+
Sbjct: 1813 KKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQD-- 1870
Query: 862 RVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQ----LA 917
++ +KA +R+ + +++ N + L ++L EA+ + + E ++ +
Sbjct: 1871 --LVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKS 1928
Query: 918 KEMRSSVDSE 927
+E+ + V SE
Sbjct: 1929 REVHTKVISE 1938
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 99.4 bits (246), Expect = 2e-20
Identities = 183/899 (20%), Positives = 372/899 (41%), Gaps = 117/899 (13%)
Query: 304 EKLKLDLQELVVATKQSRAQRQELGVNLYEVQQ-------HLVHLQKLLEKSHDRHAMAS 356
E+LK DL+E + T +++ + + LG L + Q+ H + + L ++ DR A
Sbjct: 1067 EQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVE 1126
Query: 357 SERRQKEEELQAARALYTKTCAAANEERKKLAA---LQTEMENLALHLFYMQNIDQDMRD 413
+ ++K ++LQ + +E +KK+ L+ E++N L L +M+ ++
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQ 1186
Query: 414 DIRVMTQVVKKAETER-IRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTR 472
+ + VK ER + E++K + T L I EA L E+ +
Sbjct: 1187 KLNENYEEVKSITKERKVLKELQKSFE--------TERDHLRGYIREIEATGLQTKEELK 1238
Query: 473 ILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDG 532
I + E ID E RR + + + ++ + +++H + E +
Sbjct: 1239 IAHIHLKEHQETID----ELRRSVSEKTAQIINTQDLEKSHTKLQEEI------------ 1282
Query: 533 EIEAYKKSIMKEEEKNEKLASILNRTETEATL--LQKLTTQCLTKQVALQSQFNTYRLTL 590
++ EE+ E L ++ +ET+ T+ L+ LT Q TK ++ RL L
Sbjct: 1283 -------PVLHEEQ--ELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL 1333
Query: 591 QDTEDALSQDQLEQMILTEE---LQAIRQAIQGE----LELRRKTDAAIREKLQEHMTS- 642
+ + Q E LT+E L+ I++A++ + E R+T A I+E + S
Sbjct: 1334 NEK---FQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSL 1390
Query: 643 ------NKTTKYFNQL---------ILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSR 687
N+TTK +++ +LR++ E + L + + ++ +
Sbjct: 1391 NMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRL 1450
Query: 688 LDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGE 747
+ Q +L +++K++ ++ E+ ++ ++ IN L L +E+
Sbjct: 1451 QEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTI 1510
Query: 748 EVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHI 807
+ LE +L I E K Q + + QE V ++ +E + D++ L
Sbjct: 1511 QK-QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSA---LQS 1566
Query: 808 MEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENE 867
+E K L + +++++ Q+EI+ +K+ + ++K++ + R ++L++N + E
Sbjct: 1567 IESKMLELTNRLQES---QEEIQIMIKEKE-EMKRVQEALQIER---DQLKENTK----E 1615
Query: 868 FVRSLKAS---ERETIKM------QDKLNQLSEEKATLLNQLVEAEH----QIMLWEKKI 914
V +K S E + +KM Q+K+ ++ K Q + E+ I L +
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH 1675
Query: 915 QLAKEMRSSVDSEIGQTEIR-AMKGEIHRMKVRLGQLL-----KQQEKMIRAMELAVARR 968
+ +EMRS + +K E ++K L + + KQ+E I M L +
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
Query: 969 ETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSS 1028
+ K + + + D H L+ + +++ + E +ET +
Sbjct: 1736 TIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRG 1795
Query: 1029 SLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQ-AVKEGRYVFLF 1087
+ EK +KLS +Q D + A L + N +++ L+ + Q V E +
Sbjct: 1796 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 1088 RSKQSLVLER---------QRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKLE 1137
QSL L + Q+L + L + +++ + RD + +E L + L+
Sbjct: 1856 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM-KERDNLRRVEETLKLERDQLKESLQ 1913
Score = 92.8 bits (229), Expect = 2e-18
Identities = 164/832 (19%), Positives = 343/832 (41%), Gaps = 91/832 (10%)
Query: 295 LKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAM 354
L+N L+ ++E L+ K+ + ++ + ++ +++ + L LE D M
Sbjct: 573 LENELSSKVELLR---------EKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623
Query: 355 ASSERRQKEEELQAAR--ALYTKTCAAANEERKKLAALQTEMENLALHLFYMQ------- 405
+ + L A R A E+ K+LA +MEN + L+ Q
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN-DIQLYQSQLEAKKKM 682
Query: 406 --NIDQDMRDDIRVMTQVV-----KKAETERIRAEIEKKKQDLY--VDQLTTRAQQLEED 456
+++++++ +T++ K + E+E K DL +++ + L E+
Sbjct: 683 QVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREE 742
Query: 457 IALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAV 516
+ L +E R LRK + + E+ I+ EK ++ + + H++ + +
Sbjct: 743 VILLSELKSLPSEVER-LRKEIQDKSEELHIITSEKDKLFSE-------VVHKESRVQGL 794
Query: 517 LEA-------LRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLT 569
LE L Q KSTD E + +K M E+K + + R E L K
Sbjct: 795 LEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854
Query: 570 TQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTD 629
+ + AL+++ + LQ+ + Q++L +M E+L+ + L+ +
Sbjct: 855 QKFDSSLGALKTELSYKTQELQEKTREV-QERLNEM---EQLKEQLENRDSTLQTVEREK 910
Query: 630 AAIREKLQEHMTSNKTTKY----FNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTS 685
I EKLQ+ + KT QL LQ E+ + + + T + +
Sbjct: 911 TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL 970
Query: 686 SRLDAHQKTLVELDQDVKK-------VNELITNSQSEISRRTILIERKQGLINFLNKQLE 738
L HQ+T+ L + + + E ++ E ++ + I++KQ L K +
Sbjct: 971 ESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL---EAKNTQ 1027
Query: 739 RMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQ-----QEMVKVTQEQEE 793
+ +++ E+ +E + K S + ++++ + + V + Q +E +++T E +E
Sbjct: 1028 TLTADVKDNEI--IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE 1085
Query: 794 QLASL-DASKKELHIMEQKK---LRVESKIEQEKKEQKEIEHHMKDLDNDL-KKLNMLMN 848
+L L D KK+ I+ Q+K ++ E ++ + E+E +K+ L +K L+N
Sbjct: 1086 ELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN 1145
Query: 849 KNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIM 908
E E ++ E E +++ ++ T L + E+ L +L E ++
Sbjct: 1146 ---VQEEMSEMQKKINEIENLKNELKNKELT------LEHMETERLELAQKLNENYEEVK 1196
Query: 909 LWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARR 968
K+ ++ KE++ S ++E + +R EI ++ + LK ++ +
Sbjct: 1197 SITKERKVLKELQKSFETE--RDHLRGYIREIEATGLQTKEELKIAHIHLK------EHQ 1248
Query: 969 ETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSS 1028
ET+ + + + D +L+ +I V E V E+ ETQ ++
Sbjct: 1249 ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI-PVLHEEQELLPNVKEVSETQETMNE 1307
Query: 1029 SLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKE 1080
L ++ + +E + RL +++ EI +L +L+ +KE
Sbjct: 1308 LELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359
Score = 87.4 bits (215), Expect = 7e-17
Identities = 172/983 (17%), Positives = 408/983 (41%), Gaps = 124/983 (12%)
Query: 244 FQDQIQQPSTEEGAMAERV-ESEGSDEEAEDEGSQLVVLDPDHPLMV-RFQAALKNYLNR 301
++ Q Q T E + ER+ E E E+ E+ S L ++ + L+ + Q L+
Sbjct: 870 YKTQELQEKTRE--VQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE----- 922
Query: 302 QIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQ 361
+++ L + +L + + +R +L ++++ + Q+ L R+A+ S ++ Q
Sbjct: 923 EVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQL-----RNALESLKQHQ 977
Query: 362 K---------EEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMR 412
+ EE+ + T +E ++K+ + + + L Q + D++
Sbjct: 978 ETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD---LEAKNTQTLTADVK 1034
Query: 413 DDI------RVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLE--EDIALF---- 460
D+ ++ + + +K E +++ + +K+ L D +E E++ L
Sbjct: 1035 DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094
Query: 461 --EAQYLAQAEDTRILRKA-VSEAC---TEIDAISVEKRRIMQQWASSLVGMKHRDEAHR 514
+ + +AQ ++ I ++ +S C E++ EK + +Q+ L+ ++ +
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 515 AVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEK-NEKLASILNRTETEATLLQKLTTQCL 573
+ + +++ K+ + +E + ++ +K NE + + T+ E +L++L
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK-ERKVLKELQKSFE 1213
Query: 574 TKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIR 633
T++ L+ T T++ L + E + +R+++ + T +
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEK 1273
Query: 634 E--KLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAH 691
KLQE + + Q +L KE + ++++ Q+T + T +R++
Sbjct: 1274 SHTKLQEEIP----VLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 692 QKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGP 751
+ L E Q+ ++ + +T + + +E K + ++ + E ++
Sbjct: 1330 RLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQS 1389
Query: 752 LELEIK--RLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIME 809
L ++ K +K++ E + + LR++ EM+ +++ +E + + KE ++
Sbjct: 1390 LNMKEKDNETTKIVSEME-QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ 1448
Query: 810 QKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFV 869
+ + ++S+ +Q K+ KEI + + +LK + + + + EL N E E
Sbjct: 1449 RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS 1508
Query: 870 RSLKASERETIKMQDKLNQLSE-EKATLLNQLVEAEHQIMLWEKKIQLAKEMRSSVDSEI 928
K E K+Q+K+ ++ E E+ + Q+ E + ++ +++ KE R + DS +
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKV----NELKQFKEHRKAKDSAL 1564
Query: 929 GQTEIRAMK--GEIHRMKVRLGQLLKQQEKMIRAME-LAVAR-------RETVTTQAEGQ 978
E + ++ + + + ++K++E+M R E L + R +E V E Q
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 979 RK------------------------------------MDRKALTRTDFHHKQLELRRKI 1002
K ++ + + T H+ LE R +
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
Query: 1003 ---RDVRKATDECTKTVL-ELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALK 1058
RD ++ +E K +L+E R + LEKQE+L ++ + + +L +
Sbjct: 1685 TKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 1059 RQNLSEIVALQTRLKH---------LQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIAT 1109
+ +EI +Q L+H L+ +E R + +Q ++ +DK +++
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQ-----QETIDKLRGIVSE 1799
Query: 1110 ILDRVRDEYPQFQEALHKVSQMI 1132
D++ + + + K+ + I
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKI 1822
Score = 80.9 bits (198), Expect = 6e-15
Identities = 180/829 (21%), Positives = 334/829 (40%), Gaps = 161/829 (19%)
Query: 424 KAETERIRAEIEKKKQDLYVDQLTTRAQQLEED---IALFEAQYLAQAEDTRI---LRKA 477
+A +R R EI K+ L L TRAQ +E+D L E L + ++ +I R
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
Query: 478 VSEACTEIDAISVEKRRIMQQWASSLVG-MKHRDEA-------------HRAVLEALRGC 523
V+ + + KR+ W + MK+ + A H+ + LR
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461
Query: 524 QHQAKSTDGEIEAYKKSIMKEEEKN--------EKLASILN----------------RTE 559
++ ++ ++ + + E E N E + S LN RTE
Sbjct: 462 D-ESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE 520
Query: 560 TEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQ 619
E L+ L + AL+ R T +D E L + L + + Q ++
Sbjct: 521 KEEMELKLKEKNDLDEFEALE------RKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 620 GEL----ELRRKTDAAIREKLQEHMTSNK----------------TTKYFNQLILR---- 655
EL EL R+ + I+ KLQE++ S K K Q +
Sbjct: 575 NELSSKVELLREKEDQIK-KLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV 633
Query: 656 ----------LQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKV 705
L+ E + + ++ Q DI S+L+A +K V+L+++++
Sbjct: 634 ALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQ-- 691
Query: 706 NELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDE 765
++ +EI++ T LI+ K N +LE +++L E +E ++I
Sbjct: 692 -----SAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746
Query: 766 HDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHI-MEQKKLRVESKIEQEKK 824
+ K++ ++V LR K Q++ E+L + + K +L + K+ RV+ +E+ K
Sbjct: 747 SELKSLPSEVERLR------KEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 825 EQKEI---EHHMKDLDNDLKKLNML-MNKNRCSSEELEQNNRVTE---------NEFVRS 871
+ ++ + + K D + + L M+ + LE+N R+ + +F S
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860
Query: 872 LKASERE-----------TIKMQDKLNQLSEEKATLLN-----QLVEAEHQIMLWEKKIQ 915
L A + E T ++Q++LN++ + K L N Q VE E + ++ EK Q
Sbjct: 861 LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE-KTLITEKLQQ 919
Query: 916 LAKEMRSSVD--------SEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVAR 967
+E+++ E Q E +K +IH + + QE++ A+E
Sbjct: 920 TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHD---TVNMNIDTQEQLRNALESLKQH 976
Query: 968 RETVTT-----QAEGQRKM---DRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVL-- 1017
+ET+ T E R + + T+ +F K + + +K K T T V
Sbjct: 977 QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036
Query: 1018 ELEETQRNVSSSLLEK---QEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKH 1074
E+ E QR + S + EK Q+ L + A+ + L+ DL + +N E+ L LK
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096
Query: 1075 LQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQE 1123
Q + + + K + + L + +A + ++++++ Q QE
Sbjct: 1097 QQEI-------VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Score = 72.8 bits (177), Expect = 2e-12
Identities = 145/837 (17%), Positives = 361/837 (43%), Gaps = 81/837 (9%)
Query: 299 LNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSE 358
L Q K++ +L+ + K+ + +L + E L ++QK LE S+ ++
Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSN-------AK 1817
Query: 359 RRQKEEELQAARALYTKTCAAANEERKKLAAL-----QTEMENLALHLFYMQNID--QDM 411
++K +EL+A NE +KK++ + Q + ++L L ++N++ Q +
Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877
Query: 412 RDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLT-TRAQQLEEDIALFEAQYLAQAED 470
+++ M V+K+ + R E K ++D + L T+A+ LE L A+ L++
Sbjct: 1878 HENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHK 1937
Query: 471 TRI--LRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQ---H 525
+ LR+ +SE +I I + + + + ++ ++ V E + +
Sbjct: 1938 ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN 1997
Query: 526 QAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNT 585
+ + + EA S+ N +L L+ + E ++ K + + +L+ + +
Sbjct: 1998 EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ 2057
Query: 586 YRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKT 645
+ TL++ +++D+ + E+ + + Q E R+ + I+E L+ + +
Sbjct: 2058 FIATLREM---IARDRQNHQVKPEK-RLLSDGQQHLTESLREKCSRIKELLKRYSEMDDH 2113
Query: 646 TKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKV 705
+ N+L L L+KE ++ +++ L H A+Q+ +E + +KK+
Sbjct: 2114 YECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKL 2173
Query: 706 NELITN-SQSEISRRTILIERKQGLINFLNKQLERMVS--------ELGGEEVGPL---- 752
+++ ++ + + + + + I+ + KQ E ++ ++ E+ L
Sbjct: 2174 KYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQ 2233
Query: 753 --ELEIKRLSKLIDEHDGKAVQAQV---------------TWLRLQQEMVKV---TQEQE 792
+L I+ + K E + +++ + WL + ++ K+ Q++
Sbjct: 2234 NMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN 2293
Query: 793 EQLASLD--ASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKN 850
+++ ++ + + + IM + E + KE ++ +K+ + L K + +
Sbjct: 2294 DRICQVNNFFNNRIIAIMNE-STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTS 2352
Query: 851 RCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLW 910
S ++ + +N V S +A++ T K+++ N L E K + +++ E +I+
Sbjct: 2353 LASGAQVNPTTQDNKNPHVTS-RATQLTTEKIRELENSLHEAKESAMHK----ESKIIKM 2407
Query: 911 EKKIQLAKEMRSSVDSEIGQTEIRAMKG----EIHRMKVRLGQLLKQQEKMIRAMELAVA 966
+K++++ ++ + + +++ ++ K ++ + KV LG ++E M+L
Sbjct: 2408 QKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKI 2467
Query: 967 RRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNV 1026
E + E ++++ T Q E+ R +R+ + + + T + E T
Sbjct: 2468 DLEKMKNAKEFEKEISATKAT----VEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQP 2523
Query: 1027 SS--------SLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHL 1075
S+ S + + K +++++ LE ++++L Q + + L + +HL
Sbjct: 2524 SNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHL 2580
Score = 49.3 bits (116), Expect = 2e-05
Identities = 88/473 (18%), Positives = 203/473 (42%), Gaps = 58/473 (12%)
Query: 680 DITHTSSRLDAHQKTLVELDQDVKKVNELITNSQS-EISRRTILIERKQGLINFLNKQLE 738
+++ + L ++K +++L + +++V+ L T +Q+ E + L+E K L N+++E
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVS-LETRAQAMEKDQLAQLLEEKDLLQKVQNEKIE 395
Query: 739 RMVSELGGEEVGPLELEIK------------RLSKLIDEH--DGKAVQAQVTWLRLQQEM 784
+ L L+ E+K +++K+ + + D + +T + +
Sbjct: 396 NLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNIT-TKTHKLS 454
Query: 785 VKVTQEQEEQLAS-LDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKL 843
+ + +E +E + S D L + + + +K+ ++ + E+ D D
Sbjct: 455 INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYD------ 508
Query: 844 NMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEA 903
N++++ + +E+ E ++ E + +A ER+T K Q+ QL E + L N + A
Sbjct: 509 NLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEM--QLIHEISNLKNLVKHA 566
Query: 904 EHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMEL 963
E E ++ E+ + +I + + ++ +K+ L L+ E + M+
Sbjct: 567 EVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDP-KQMKQ 625
Query: 964 AVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQ 1023
+ ETV A+ + R + LEL+ K++++ T + E
Sbjct: 626 TLFDAETVALDAKRESAFLRS---------ENLELKEKMKEL--------ATTYKQMEND 668
Query: 1024 RNVSSSLLEKQEKLSV-IQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGR 1082
+ S LE ++K+ V ++ + + ++T+L +L + + + L EG+
Sbjct: 669 IQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLEL-------EGK 721
Query: 1083 YVFLFRSKQSLVLERQRLDKRLALIATI------LDRVRDEYPQFQEALHKVS 1129
L + V E + L + + L++ + ++R+R E E LH ++
Sbjct: 722 ITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIIT 774
Score = 47.8 bits (112), Expect = 6e-05
Identities = 129/730 (17%), Positives = 290/730 (39%), Gaps = 115/730 (15%)
Query: 296 KNYLNRQIEKLKLDLQELVVATKQSRAQ----RQELGVNLYEVQQHLVHLQKLLEKSHDR 351
++ L R E LKL+ +L + ++++A+ +QEL ++H + KL EK ++
Sbjct: 1891 RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK 1950
Query: 352 HAMASS----------ERRQKEEELQAARALYTKTCAAANEERKKLAAL-----QTEMEN 396
S E ++K +ELQ + N KK+ + Q E +N
Sbjct: 1951 TIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010
Query: 397 LALHLFYMQNID-----QDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQ 451
L++ M N + ++IR++ + ++ E RI+ ++ ++ A+
Sbjct: 2011 LSMQSVRMDNFQLTKKLHESLEEIRIVAK--ERDELRRIKESLKMERDQFIATLREMIAR 2068
Query: 452 QLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAI----------------------- 488
+ E + L+ + L +++ E C+ I +
Sbjct: 2069 DRQNHQVKPEKRLLSDGQQH--LTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEK 2126
Query: 489 SVEKRRIMQQWASSLVGMKHRDEAH-RAVLEALRGCQHQAKSTDGEIEAYKKSIMK-EEE 546
+E ++ + + + + + H + A + C + +++ + K +EE
Sbjct: 2127 EIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEE 2186
Query: 547 KNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMI 606
++E + N+ E + + + L K LQ + L+D + + D + I
Sbjct: 2187 QHESI----NKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242
Query: 607 LTE----ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNK--------------TTKY 648
L + E +I+ Q L R++ + E L K +
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNF 2302
Query: 649 FNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNEL 708
FN I+ + E T + I+ + Q + + +L + +TL +VN
Sbjct: 2303 FNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPT 2362
Query: 709 ITNSQSE--ISRRTILIERK-QGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDE 765
++++ SR T L K + L N L++ E + + ++ ++ E++ + +I +
Sbjct: 2363 TQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK--ESKIIKMQKELEVTNDIIAK 2420
Query: 766 HDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDAS--KKELHIMEQKKLRVE-SKIEQE 822
K ++ L +E ++V Q++ +L A K+E+ ++ K ++++ K++
Sbjct: 2421 LQAKVHESNKC-LEKTKETIQVLQDK----VALGAKPYKEEIEDLKMKLVKIDLEKMKNA 2475
Query: 823 KKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENE--------------- 867
K+ +KEI ++ K++ L+ +N S++ + + ++E+
Sbjct: 2476 KEFEKEISATKATVEYQ-KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGS 2534
Query: 868 -FVRSLKAS---------ERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLA 917
V++ KA E+E K++ + QL ++K LL+ +++ W+++ L
Sbjct: 2535 GIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKER-TLK 2593
Query: 918 KEMRSSVDSE 927
+E V E
Sbjct: 2594 REAHKQVTCE 2603
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 98.6 bits (244), Expect = 3e-20
Identities = 169/787 (21%), Positives = 331/787 (42%), Gaps = 108/787 (13%)
Query: 412 RDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQAEDT 471
++DI + VK+ E +R + +D V+ L ++L+ + L E Q + + E
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC 1825
Query: 472 RILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTD 531
L K V E E +S EK L+ E + LE H KS+
Sbjct: 1826 IELEKIVGELKKENSDLS-EKLEYFSCDHQELLQRVETSEGLNSDLE-----MHADKSSR 1879
Query: 532 GEI--------EAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQF 583
+I +++K+ + E + ++ S E EA L+ T+++ L+
Sbjct: 1880 EDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1939
Query: 584 NTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAI-------REKL 636
+ + E+ LS ++T E R ++GEL+ K A+ +EK
Sbjct: 1940 ENKQKVIVCLEEELS-------VVTSE----RNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
Query: 637 QEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLV 696
QE + + Q+ KEKT ++ LS D+++ D TH +L
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSS---DVSELLKDKTHLQEKL-------- 2037
Query: 697 ELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLE-LE 755
Q ++K ++ ++ ++ E+ + + +++ L+ ++ L+ +SE E++ + LE
Sbjct: 2038 ---QSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALE 2094
Query: 756 IKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRV 815
+ K + Q +V LR E ++V E +E KK+LHI E+ K R
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE--------KKQLHIAEKLKERE 2146
Query: 816 -ESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSS-----EELEQNNRVTENEFV 869
E+ ++K E E E M + + +L L+ +K + EE+ ++ +V E + V
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
Query: 870 RSLKASERETIKMQDKLNQLSE------EKATLLNQLVEAEHQIMLWEKKI-----QLAK 918
E T ++Q+K QLSE +LL + +AE QI K K
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK 2266
Query: 919 EMRSSVDSEIGQTEI---------------RAMKGEIHRMKVRLGQLLKQQEKMIRAMEL 963
E+ +V + G EI ++ I +++ RL K+Q +++ ++
Sbjct: 2267 ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326
Query: 964 AVARRETVTTQAEG-QRKMDRKALTRTDFHHKQLE----------LRRKIRDVRKATDEC 1012
+ + + + E +R+++ + RT+ H LE L+ KI + ++
Sbjct: 2327 SEHHADLLKGRVENLERELE---IARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL 2383
Query: 1013 TKTVLELEETQRNVSSSLLEKQEKLS---VIQADFDT-LEADLTRLGALKRQNLSEIVAL 1068
V+ + + N+++ L ++QE++S +I + F+ L+ +K ++ + + L
Sbjct: 2384 ELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEML 2443
Query: 1069 QTRLKHLQ---AVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEAL 1125
QT+LK L A +Q+L + + L+ A + LD ++ Y Q ++
Sbjct: 2444 QTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSV 2503
Query: 1126 HKVSQMI 1132
+ + Q +
Sbjct: 2504 NGLIQEV 2510
Score = 81.6 bits (200), Expect = 4e-15
Identities = 157/845 (18%), Positives = 340/845 (40%), Gaps = 123/845 (14%)
Query: 295 LKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAM 354
+K L +++++ K L + + +Q+L NL E +Q L ++ + S +
Sbjct: 417 MKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ----I 472
Query: 355 ASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDD 414
+E R+ EE++ L + + ++ +++ L+ E++N+ L QN ++M+
Sbjct: 473 KENELRRSMEEMKKENNLLK---SHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK-- 527
Query: 415 IRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLE------EDIALFEAQYLAQA 468
++ ++ +I +++ L +++L LE +D+ ++ Q
Sbjct: 528 ---AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 469 EDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAK 528
D L K E+ + A+ ++K+ + + + E + +L + + +
Sbjct: 585 NDK--LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEK-LLTQMESEKENLQ 641
Query: 529 STDGEIEA-YKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYR 587
S +E K +K E NE++ ++ E + ++ L +K V +++Q Y
Sbjct: 642 SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYM 701
Query: 588 LTLQDTE--DALSQDQLEQMIL--------TEELQAIRQAIQGEL--------ELRRKTD 629
Q E D Q ++E M L E+L+ Q + E+ +L + +
Sbjct: 702 ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE 761
Query: 630 AAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLD 689
+ +R+ L+ S T + + +L ++ M + I G+ Q ++ + RL+
Sbjct: 762 S-LRDLLKSKDASLVTNEDHQRSLLAFDQQPA-MHHSFANIIGE--QGSMPSERSECRLE 817
Query: 690 AHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEV 749
A DQ K L Q+ + +E ++ + + L KQ E +V G
Sbjct: 818 A--------DQSPKNSAIL----QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG---- 861
Query: 750 GPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIME 809
E+E + L K H + +LQ++ E L++L+ +KEL ++
Sbjct: 862 ---EIE-ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLN 917
Query: 810 QKKLRVESKIEQEKKEQKEIEHHMKD-------LDNDLKKLNMLMNKNRCSSEELEQNNR 862
K +++I++ KK +E +K+ L + K+++ +++ N+ EEL Q N
Sbjct: 918 DKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENG 977
Query: 863 VTENEFVRSLKASERETIKMQDKL---------------NQLSEEKATLLNQLVEAEHQI 907
T E SL + I+ + +Q +EK LL + E +
Sbjct: 978 -TLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 908 MLWEKKIQLAKEMRSSVDSEIGQ--TEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAV 965
+K + A+E S ++ + + + K E+ ++K K+ ++ + + A
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFA---KEHQEFLTKLAFAE 1093
Query: 966 ARRETVTTQAEGQRKMDRKALTRTDFHHK----------------QLELRRKIRDVRKAT 1009
R + + + E ++ R +T + K Q ++++++ D+ +
Sbjct: 1094 ERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQEN 1153
Query: 1010 DECTKTV--------LELEETQRNVSSSLLEK-------QEKLSVIQADFDTLEADLTRL 1054
++ K + LE E + +V E+ Q L V + D+ A L +L
Sbjct: 1154 EQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL 1213
Query: 1055 GALKR 1059
A+ R
Sbjct: 1214 EAMLR 1218
Score = 80.5 bits (197), Expect = 8e-15
Identities = 156/920 (16%), Positives = 374/920 (40%), Gaps = 103/920 (11%)
Query: 241 LPVFQDQIQQPSTEEGAMAERVESEGSDEEAE-----DEGSQLVVLDPDHPLMVRFQAAL 295
L + + ++ + E+++S D +A + +Q+ L+ + L+V+ +L
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
Query: 296 KNYLNRQ-IEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDR--- 351
+ L+ EKL + A + + ++ E + L Q+ + L++ +EK R
Sbjct: 2076 QARLSESDYEKLNVSK-----ALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEA 2130
Query: 352 ------HAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQ 405
H + R++E + + + +EE ++L L + EN + ++
Sbjct: 2131 DEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL--DAENSKAEVETLK 2188
Query: 406 NIDQDMRDDIRV--MTQVVKKAETERIRAEIEKKKQDLY-VDQLTTRAQQLEEDIALFEA 462
++M ++V + V ++E E + +I++K+ L +D+L + + L E+ E
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI 2248
Query: 463 QYLAQAEDT--------RILRKAVSEACTEIDAISVEKRRI------MQQWASSLVGMKH 508
Q +++ + L +AV+ C + + + ++ + Q +S+ ++
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRA 2308
Query: 509 RDEAHR----AVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATL 564
R EA VL+ L+ +H A G +E ++ + E A ++ E
Sbjct: 2309 RLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVET 2368
Query: 565 LQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELEL 624
L+ L+ T R ++ + L ++Q EL+ I + + L+
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER----ISELEIINSSFENILQE 2424
Query: 625 RRKTDAAIREKLQEHMTSNKTT-KYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITH 683
+ + ++EK M +T K N+ + L ++ ++ + L+
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQ 2484
Query: 684 TSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSE 743
LD + + L V + + + + + ++ E+K I+ L Q++
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-------EKKDEEISRLKNQIQDQ--- 2534
Query: 744 LGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQ---LASLDA 800
E + +LS++ EH W E+ +T E E++ L S +A
Sbjct: 2535 ---------EQLVSKLSQVEGEHQ--------LWKEQNLELRNLTVELEQKIQVLQSKNA 2577
Query: 801 SKKE-LHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQ 859
S ++ L +++ +E+++E K ++ + + +L M++ + EL++
Sbjct: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE 2637
Query: 860 NNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKE 919
+N L+ E +D+L +L+ E + L L + H K Q+ KE
Sbjct: 2638 ELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL-DCMH-------KDQVEKE 2689
Query: 920 MRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQR 979
V EI + ++R + E + L + + ++ E ++ E +++Q +
Sbjct: 2690 --GKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQ---KL 2744
Query: 980 KMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEKLSV 1039
++D ++ + ++ + + +++K + K V +L++ + +
Sbjct: 2745 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ 2804
Query: 1040 IQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQA-VKEGRYVFLFRSKQ------- 1091
++ + + L+ +L++L A + + + V + T++ L +KE + ++K+
Sbjct: 2805 LEEEKEILQKELSQLQAAQEKQKTGTV-MDTKVDELTTEIKELKETLEEKTKEADEYLDK 2863
Query: 1092 --SLVLERQRLDKRLALIAT 1109
SL++ ++L+K ++ T
Sbjct: 2864 YCSLLISHEKLEKAKEMLET 2883
Score = 78.6 bits (192), Expect = 3e-14
Identities = 146/741 (19%), Positives = 304/741 (41%), Gaps = 84/741 (11%)
Query: 385 KKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVD 444
+K+ L+ +++ L Q + ++ Q V+ +TE + E ++ +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 445 QLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLV 504
L Q++ ++ + E+Q Q +K + + E+ E R Q S+ V
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 505 GMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATL 564
+ + + L Q+ + S + E K+ KE E+ ++L E E
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGS---KYEDLKEKYNKEVEERKRL-------EAEVKA 187
Query: 565 LQ-KLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELE 623
LQ K +Q L Q+ N + ++ Q E+ L + Q
Sbjct: 188 LQAKKASQTLP-----QATMNHRDIARHQASSSVFSWQQEK--TPSHLSSNSQ----RTP 236
Query: 624 LRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITH 683
+RR A+ QE S T + + + ++ L ++ + I
Sbjct: 237 IRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINE 296
Query: 684 TSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLINFLNKQLERMVSE 743
RL H+K E+ V K EL Q ++ + + + K+ ++N +L R ++
Sbjct: 297 LELRLQGHEK---EMKGQVNKFQEL----QLQLEKAKVELIEKEKVLNKCRDELVRTTAQ 349
Query: 744 LGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKK 803
LE ++L KL ++ + A+ L+Q K+ ++++E L ++
Sbjct: 350 YDQASTKYTALE-QKLKKLTEDLSCQRQNAESARCSLEQ---KIKEKEKEFQEELSRQQR 405
Query: 804 ELHIMEQKKLRVESKIEQEKKEQKEIEHHM-----------KDLDNDLKKLNMLMNKNRC 852
++Q+ +++++++ QE ++ K + + + + L+N+L++ + C
Sbjct: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL----C 461
Query: 853 SSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQL-VEAEHQIMLWE 911
+E+ Q +++ ENE RS++ ++E + L SE+KA + L E ++
Sbjct: 462 RAEQAFQASQIKENELRRSMEEMKKE----NNLLKSHSEQKAREVCHLEAELKNIKQCLN 517
Query: 912 KKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETV 971
+ A+EM++ S+ +T +R ++ +I+ QQE + +L +A
Sbjct: 518 QSQNFAEEMKAKNTSQ--ETMLRDLQEKIN-----------QQENSLTLEKLKLA----- 559
Query: 972 TTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLL 1031
E QR + L + + H +QL D T++ +K +L E ++ L
Sbjct: 560 VADLEKQRDCSQDLLKKREHHIEQL------NDKLSKTEKESKALLSALELKKKEYEELK 613
Query: 1032 EKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGRYVFLFRSKQ 1091
E++ S +++ + L LT++ + K S+I L+T LK Q +K Y R
Sbjct: 614 EEKTLFSCWKSENEKL---LTQMESEKENLQSKINHLETCLK-TQQIKSHEYNERVR--- 666
Query: 1092 SLVLERQRLDKRLALIATILD 1112
+L ++R+ L + + +LD
Sbjct: 667 TLEMDRENLSVEIRNLHNVLD 687
Score = 63.9 bits (154), Expect = 8e-10
Identities = 173/949 (18%), Positives = 368/949 (38%), Gaps = 144/949 (15%)
Query: 289 VRFQAALKNYLNRQIEKLKLDLQ--ELVVATKQSRAQRQELGVNLYEVQQHL-------- 338
V FQ N +QIEKL+ +L+ + + Q AQ ++ +N Q +
Sbjct: 97 VNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPS 156
Query: 339 -VHLQKLLEKSHDRHAMASSERRQKEEE---LQAARALYTKTCAAAN-----EERKKLAA 389
+ E +++ ER++ E E LQA +A T A N + +
Sbjct: 157 QYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSV 216
Query: 390 LQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDL-------- 441
+ E HL RD ++ R +I K+ +
Sbjct: 217 FSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSS 276
Query: 442 --YVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISV---EKRRIM 496
+DQL + Q+L I E + ++ + E +++ V EK +++
Sbjct: 277 PHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336
Query: 497 QQWASSLVGMKHR-DEA---HRAVLEALR------GCQHQAK-----STDGEIEAYKKSI 541
+ LV + D+A + A+ + L+ CQ Q S + +I+ +K
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF 396
Query: 542 MKEEEKNEKLASILNR--TETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQ 599
+E + ++ L++ + +A L Q+L Q LQ++ + Q E+ L
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQEL-QQAKNMHNVLQAELDKLTSVKQQLENNL-- 453
Query: 600 DQLEQMILTEELQAIRQAIQGELELRRKTDAAIREK--LQEHMTS--------------- 642
++ +Q + E QA + + E ELRR + +E L+ H
Sbjct: 454 EEFKQKLCRAE-QAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNI 512
Query: 643 ----NKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLD-----ITHTSSRLDAHQK 693
N++ + ++ + ++T + KIN TL+ + + D Q
Sbjct: 513 KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD 572
Query: 694 TLVELDQDVKKVNELITNSQSEISRRTILIERK----------QGLINFLNKQLERMVSE 743
L + + ++++N+ ++ ++ E +E K + L + + E+++++
Sbjct: 573 LLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ 632
Query: 744 LGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKK 803
+ E+ L+ +I L + K+ + L+ + ++ E LD+
Sbjct: 633 MESEKEN-LQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV 691
Query: 804 ELHIMEQKKLRVESKIE-QEKKEQKEIEH----------HMKDLDNDLKKL-NMLMNKNR 851
E+ + + ++ K E ++K QKEIE+ ++DL++ L+ L N +M+K+R
Sbjct: 692 EVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDR 751
Query: 852 CSSE------------ELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQ 899
C + + + + VT + RSL A +++ N + E+ +
Sbjct: 752 CYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS----- 806
Query: 900 LVEAEHQIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIR 959
M E+ + +S +S I Q + +++ + K L KQ E++++
Sbjct: 807 --------MPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858
Query: 960 AM-----ELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQL-----ELRRKIRDVRKAT 1009
L A + + AE +++ K T H + L K ++++
Sbjct: 859 IKGEIEENLMKAEQMHQSFVAETSQRIS-KLQEDTSAHQNVVAETLSALENKEKELQLLN 917
Query: 1010 DECTKTVLELEETQRNVSSSLLEKQ-EKLSVIQADFDTLEADLTRLGALKRQNLSEIVAL 1068
D+ E++E ++ S+ LLE ++L ++ + +++ + +L ++ + E+
Sbjct: 918 DKVETEQAEIQELKK--SNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQE 975
Query: 1069 QTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDE 1117
LK + A + L + +S +D+R I+ + D+ + E
Sbjct: 976 NGTLKEINASLNQEKMNLIQKSESFA---NYIDEREKSISELSDQYKQE 1021
Score = 54.7 bits (130), Expect = 5e-07
Identities = 125/696 (17%), Positives = 287/696 (41%), Gaps = 93/696 (13%)
Query: 380 ANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQ 439
A++ K A LQ +++L L + ++ D++ + Q+ + E ++AE +
Sbjct: 818 ADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE---QMH 874
Query: 440 DLYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQW 499
+V + + R +L+ED T + V+E + ++ K + +Q
Sbjct: 875 QSFVAETSQRISKLQED--------------TSAHQNVVAETLSALE----NKEKELQL- 915
Query: 500 ASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTE 559
+ + E +A ++ L+ H + + E++ +++ E+++ + S+ R
Sbjct: 916 ------LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 560 TEAT----LLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQ--DQLEQ--MILTEEL 611
E T L+++ +++ L + ++ + + E ++S+ DQ +Q +IL +
Sbjct: 970 EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC 1029
Query: 612 QAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKIN 671
+ A + +L +K AA + + N+ T L + + N + L +
Sbjct: 1030 EETGNAYE---DLSQKYKAAQEKNSKLECLLNECTS--------LCENRKNELEQLKEAF 1078
Query: 672 GDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIERKQGLIN 731
Q L T + + +Q ++EL+ + + +T++Q+ ++++ I
Sbjct: 1079 AKEHQEFL--TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQE---IM 1133
Query: 732 FLNKQLERMVSELGGEEVGPLELEIKRLSKLID-EHDGKAVQAQVTWLRLQQEMVKVTQ- 789
L ++ +M +EV L E ++L K++ +H+ + ++++ +++ + Q
Sbjct: 1134 TLKEEQNKMQ-----KEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQC 1188
Query: 790 ------EQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKL 843
+ E + SLD+ +L +E E K+++ +KE++ ++H ++ + DL+
Sbjct: 1189 NFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETS 1248
Query: 844 NMLMNKNRCSSEELEQNNRVTENEFV---RSLKASERETIKMQDKLNQLSEEKATLLNQL 900
N L + L+ E +++ L S+ + +Q L T +N+L
Sbjct: 1249 N-LQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQ-------TTMNKL 1300
Query: 901 VEAEHQI-MLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIR 959
E E +L +K +L E+ S I T +M +G+LL E I
Sbjct: 1301 NELEKICEILQAEKYELVTELNDSRSECITAT---------RKMAEEVGKLL--NEVKIL 1349
Query: 960 AMELAVARRETVTTQAEGQ-----RKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTK 1014
+ + E V G+ + +L D + L ++V+ E +
Sbjct: 1350 NDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQE 1409
Query: 1015 TVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEAD 1050
L L+ + + + K+S +Q D+L+A+
Sbjct: 1410 KFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAE 1445
Score = 34.3 bits (77), Expect = 0.69
Identities = 164/906 (18%), Positives = 344/906 (37%), Gaps = 151/906 (16%)
Query: 260 ERVESE---GSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVA 316
+ +ESE S +E E E +Q P L V+ + +L +Y N Q+ +L+ L+ +
Sbjct: 1167 QNLESEPIRNSVKERESERNQCN-FKPQMDLEVK-EISLDSY-NAQLVQLEAMLRNKELK 1223
Query: 317 TKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKT 376
++S +++ L L ++ L +S + + E +E+ + L T
Sbjct: 1224 LQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELST-- 1281
Query: 377 CAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEK 436
+ N+ +LQT M L ++ I + ++ + + + + +E I A
Sbjct: 1282 --SQNDNAHLQCSLQTTMNKLN----ELEKICEILQAEKYELVTELNDSRSECITAT--- 1332
Query: 437 KKQDLYVDQLTTRAQQLEEDIALFEAQYLA---------QAEDTRILRKAVSEACTEIDA 487
+K V +L + L +D L + + Q + + A + +
Sbjct: 1333 RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392
Query: 488 ISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEK 547
+++ + + +A H+ + + + CQ +K + E++ Y S+ E
Sbjct: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHD--QHCQMSSKMS--ELQTYVDSLKAE--- 1445
Query: 548 NEKLASILNRTE----------TEATLLQKLTTQCLTKQVALQSQFNT--YRLTLQDTED 595
N L++ L + E L+ L++ C+ +L S ++ YR L+ T D
Sbjct: 1446 NLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGD 1505
Query: 596 ALSQDQLEQMILTEEL---QAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQL 652
LE + + + ++Q E R++T +A + ++E + + Q
Sbjct: 1506 MSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE---LESLCEVYRQS 1562
Query: 653 ILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKT-LVELDQDVKKVNELITN 711
+ +L+++ M + N +I + ++ LD +K L E +Q +K+ +
Sbjct: 1563 LEKLEEK---MESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE 1619
Query: 712 SQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKL----IDEHD 767
+S+++ KQ E++ EL EV L+L+ LS ID D
Sbjct: 1620 MESKLAAE--------------KKQTEQLSLEL---EVARLQLQGLDLSSRSLLGIDTED 1662
Query: 768 G-----------KAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVE 816
K ++ T + ++ ++ + +Q +LD K I E ++
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEK----ITETGAVKPT 1718
Query: 817 SKIEQEKKEQKEIEHHMKDLD---------------NDLKKLNMLMNKNRCSSEELEQNN 861
+ E+ E +D N L ++ L N+ L+
Sbjct: 1719 GECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQE--DIHNLQLRV 1776
Query: 862 RVTENEFVRSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMR 921
+ T NE +R L E K++ LN++ E + L Q ++QL ++
Sbjct: 1777 KETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQ-------------EVQLMTKIE 1823
Query: 922 SSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKM 981
+ ++ E + +K E + +L +++++ +E + + A+ +
Sbjct: 1824 ACIELE---KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRE 1880
Query: 982 ---DRKALTRTDFHHKQLELRRKIRDVR--KATDECTKTVLE------------LEETQR 1024
D A + + L++ ++ +R KA+ E LE LE+
Sbjct: 1881 DIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE 1940
Query: 1025 NVSSSLLEKQEKLSVI-------QADFDTLEADLTRLGALK---RQNLSEIVALQTRLKH 1074
N ++ +E+LSV+ + + DT+ T L L ++ E+ + Q+ H
Sbjct: 1941 NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH 2000
Query: 1075 LQAVKE 1080
V E
Sbjct: 2001 CIQVAE 2006
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 97.8 bits (242), Expect = 5e-20
Identities = 169/839 (20%), Positives = 366/839 (43%), Gaps = 115/839 (13%)
Query: 294 ALKNYLNRQI----EKLKLDLQELVVATKQSRAQRQELGVNLYEV--QQHLVHLQKLLEK 347
A KN N++I EK K +L+ L + Q+ L +V QQ+ ++KL EK
Sbjct: 596 AEKNKHNKEITVMVEKHKTELESL-------KHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 348 SHDRHAMASSERRQKEEELQAARALYTKTCAAANEER-KKLAALQTEMENLALHLFYMQN 406
++KE L+ ++ NE+ +KL QTE+E+L+ L +
Sbjct: 649 CE----------QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 407 IDQDMRDDIRVMTQVVKKAETERIRAEIEKK---KQDLYVDQLTTRAQQLEEDIALFEAQ 463
+ +++ V+ K +T++++ E+E K +++ + Q+ + ++ E I E
Sbjct: 699 ARHKLEEELSVL-----KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA 753
Query: 464 YLAQAEDTRILRKA----VSEACTEIDAISVEKRRI---MQQWASSL-VGMKHRDEAH-- 513
Q +L K + E ++ + + +R +QQ ++ L V ++ H
Sbjct: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQ 813
Query: 514 -RAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEAT-LLQKLTTQ 571
+A E L Q + + E K + + E + + + + L+ + + L+Q+L Q
Sbjct: 814 TKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQ 873
Query: 572 CLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEE--LQAIRQAIQGELELRRKTD 629
+ ++S Y L+D Q+Q +Q+++ +E + +R+ + E+E+ +
Sbjct: 874 NSEMEQKVKSLTQVYESKLEDGNK--EQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
Query: 630 AAIREKL----QEHMTSNKTTKYFNQLILRLQKE-----KTNMMTHLSKINGDIAQTTLD 680
+A + + +E+ T K + + + + KE K ++ +K+ ++ T L+
Sbjct: 932 SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Query: 681 ITHTSSRLDAHQKTLVELDQD--VKKVNELITNSQSEISRRTILIERK-QGLINFLNKQL 737
++ + +A + + + V+ L TN + +I T + R+ +I+ K+L
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051
Query: 738 ERMVSELGGEEVGPLELEIK-------RLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQE 790
+ EL +E+ ++L+ K + L+ + + + ++TWL+ +E
Sbjct: 1052 NQQAEEL--QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK---------EE 1100
Query: 791 QEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLK--------- 841
+Q +L+ +++L +QK V S + E K + +E DL+ LK
Sbjct: 1101 GVKQDTTLNELQEQL---KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 842 -KLNMLMNKNRCSSEELEQNNRVTENEFVRSLKAS-ERETIKMQDK---LNQLSEEKATL 896
+L ML +++ EL + T+ EF +SLK+S E+ ++DK +LSEE A
Sbjct: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEF-QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216
Query: 897 LNQLVEAEHQIM--LWEKKIQLAKEMRSSVDSEIGQTEIRAMKGE---------IHRMKV 945
L+ + ++ + I ++ +++ S I + R K + + ++
Sbjct: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276
Query: 946 RLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDV 1005
+L QL ++Q + + + A + E Q + + +T + L+++ +
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE------ALQKEGGNQ 1330
Query: 1006 RKATDECTKTVLEL-EETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLS 1063
++A E + +L +E N+++ L K+E L + + +L LT L + ++S
Sbjct: 1331 QQAASEKESCITQLKKELSENINAVTLMKEE-LKEKKVEISSLSKQLTDLNVQLQNSIS 1388
Score = 77.0 bits (188), Expect = 9e-14
Identities = 153/891 (17%), Positives = 354/891 (39%), Gaps = 115/891 (12%)
Query: 290 RFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSH 349
R + K + E + +L +++ ++ Q+ E ++E+Q L ++ + +
Sbjct: 1020 RLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQ--LQEKEQEVAELK 1077
Query: 350 DRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALH----LFYMQ 405
+ + E+ + +E+ + K NE +++L + +LA +++
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137
Query: 406 NIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYL 465
++ D+ ++ T + ++ ++ AE +K+K +L T ++ + + E
Sbjct: 1138 KLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Query: 466 AQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQH 525
+ + + +K E ++D + +++ + L+ + A+L + CQH
Sbjct: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINIS--SSKTNAILSRISHCQH 1255
Query: 526 QAKS----------TDGEIEAYKKSIMKE---------------EEKNEKLASILNRTE- 559
+ T E+EA + + +E EEK ++ S+ E
Sbjct: 1256 RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIES 1315
Query: 560 --TEATLLQKL----------TTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMIL 607
TE LQK C+T Q+ + N +TL E L + ++E L
Sbjct: 1316 LVTEKEALQKEGGNQQQAASEKESCIT-QLKKELSENINAVTLMKEE--LKEKKVEISSL 1372
Query: 608 TEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILR---LQKEKTNMM 664
+++L + +Q + L K A + Q + L + L KEK + +
Sbjct: 1373 SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISAL 1432
Query: 665 THLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTILIE 724
+ + ++ SR HQ T+ EL ++ ++ +I+ ++
Sbjct: 1433 EQVDDWSNKFSEWK---KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 725 RKQGLINFLNKQLERMVSELGGEEVGPLELEIK----RLSKLIDEHDGKAV--------- 771
++ + L ++E S++ +E LE E+K R+ +L D K +
Sbjct: 1490 QQNKRFDCLKGEMEDDKSKMEKKESN-LETELKSQTARIMELEDHITQKTIEIESLNEVL 1548
Query: 772 -----QAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQ 826
Q + L Q++ + EE+ + +++++ +E + +++++E +KKE
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKEL 1608
Query: 827 KEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKL 886
+ + +K + +LK L + S+ +L + R E + K + + +++
Sbjct: 1609 EHVNLSVKSKEEELKALEDRLESE--SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 887 NQLSEEKATLLN-QLVEAEHQIMLWEKKI--------------QLAKEMRSSVDSEIGQT 931
+ +E + LN +L E E ++ + E+K+ + AK + + + E +
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
Query: 932 EIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDF 991
+ K ++ V L + L ++EK+++ + + ETV++ E + + + +
Sbjct: 1727 QGCVQKTYEEKISV-LQRNLTEKEKLLQ--RVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 992 HHKQLELRRKIRDVRKATDECTK--------------------TVLELEETQRNVSSSLL 1031
KQ E + I +++ +E K LE +V +L
Sbjct: 1784 EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ 1843
Query: 1032 EKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKEGR 1082
EK+ +++ L++ L R + R + E+ + +L+ LQ + +GR
Sbjct: 1844 EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM-DGR 1893
Score = 71.2 bits (173), Expect = 5e-12
Identities = 158/806 (19%), Positives = 334/806 (41%), Gaps = 93/806 (11%)
Query: 261 RVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQELVVATKQS 320
+++ E +EA ++ Q+ +L + + LK + K++ L K
Sbjct: 1464 QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ 1523
Query: 321 RAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQKEEELQAARALYTKTCAAA 380
A+ EL + + Q + ++ L E + + E ++ ++LQ + L +
Sbjct: 1524 TARIMELEDH---ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 381 NEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQD 440
E +K+ L+ ++ ++ L + + ++ + VK E E ++A +E + +
Sbjct: 1581 KEAEEKILTLENQVYSMKAEL-------ETKKKELEHVNLSVKSKE-EELKA-LEDRLES 1631
Query: 441 LYVDQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSEA-CTEIDAISVEKRRIMQQW 499
+L ++ E+ IA + Q L+Q E+ K +E+ +E++ E+ R +
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 500 ASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKEEEKNEKLASILNRTE 559
L K + + L R ++ A T+ E + + K E EK+ S+L R
Sbjct: 1692 EEKL---KSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE--EKI-SVLQRNL 1745
Query: 560 TEAT-LLQKL---TTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQA-- 613
TE LLQ++ + ++ ++ Q+ + L+ E +DQ L EEL+
Sbjct: 1746 TEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKN 1805
Query: 614 ------IRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHL 667
+ Q ++ E K + ++ L+ + T +L ++ ++K +
Sbjct: 1806 KKYSLIVAQHVEKE---GGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
Query: 668 SKINGDIAQTTLD-ITHTSSRLDAHQKTLVELDQDVKKVNELITNSQSEISRRTIL---- 722
++ + ++ +T +L A Q+ K EL+ + E S+ ++
Sbjct: 1863 LVRQKEVHRVEMEELTSKYEKLQALQQM-----DGRNKPTELLEENTEEKSKSHLVQPKL 1917
Query: 723 ---IERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLR 779
+E + + F ER +LG +E+ L+ +++ L K EH + + + +
Sbjct: 1918 LSNMEAQHNDLEFKLAGAEREKQKLG-KEIVRLQKDLRMLRK---EHQQELEILKKEYDQ 1973
Query: 780 LQQEMVKVTQEQEEQLASLDASKKELHI-----MEQKKLRVESKIEQEKKEQKEIE---- 830
++E +K QEQE+ +++ K+L + QK+ +E I++ + +E+E
Sbjct: 1974 EREEKIK--QEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELL 2031
Query: 831 -HHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERE-TIKMQDKLNQ 888
H ++ + LKK+ E + + + T + L A E E T K++D Q
Sbjct: 2032 ESHQEETNQLLKKI-----------AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ 2080
Query: 889 LSEEKATLLNQLVEAEH----QIMLWEKKIQLAKEMRSSVDSEIGQTEIRAMKGEIHRMK 944
L E + +L + E+ + + E + QLA++ DS++ + E R +IH ++
Sbjct: 2081 LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE---QIHNLE 2137
Query: 945 VRLGQLLKQQEKMIRAMELAVARR-------ETVTTQAEGQRKMDRKALTRTDFHHKQLE 997
R LK+ EK + A + + + + + RK L +
Sbjct: 2138 DR----LKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKT 2193
Query: 998 LRRKIRDVRKATDECTKTVLELEETQ 1023
+ + I V K D+ T+ +LE E+ +
Sbjct: 2194 MAKVITTVLKFPDDQTQKILEREDAR 2219
Score = 67.8 bits (164), Expect = 6e-11
Identities = 143/745 (19%), Positives = 309/745 (41%), Gaps = 102/745 (13%)
Query: 475 RKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRA-VLEALRGCQHQAKSTDGE 533
R++++ + S + M A LVG + D ++ +++ LR + S G+
Sbjct: 99 RESLNRLDLDSSTASFDPPSDMDSEAEDLVG--NSDSLNKEQLIQRLRRMERSLSSYRGK 156
Query: 534 IEAYKKSIMKEEEKNEKLASILNRTETEATL-LQKLTTQCLTKQVALQSQFNTYRLTLQD 592
+ + + +KL IL++++ ++ + +L + Q A + + +L++
Sbjct: 157 YSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEE 216
Query: 593 TEDALSQDQLEQMILTEELQAIRQAI-----------QGELELRRKTDAAIREKLQEHMT 641
+ +S Q + +L + L+ + Q E+ + + + E + E T
Sbjct: 217 KDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGT 276
Query: 642 SNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQD 701
S KT + Q R+++++ + I Q TL +S +A Q+ L E Q+
Sbjct: 277 SVKTLETLQQ---RVKRQENLLKRCKETIQSHKEQCTL----LTSEKEALQEQLDERLQE 329
Query: 702 VKKVNELITNSQSEI-----SRRTIL--IERKQGLINFLNKQLERMVSELGGEEVGPLEL 754
++K+ +L ++++ + ++ +E+ +G++ K+ E+ EE+ L
Sbjct: 330 LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389
Query: 755 EIKRLS---KLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQL-ASLDASKKELHIMEQ 810
IK+++ + + E K+ +A L + T+E +L A +D K + +
Sbjct: 390 RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE 449
Query: 811 KKLRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSE-ELEQNNRVTENEFV 869
++ R+ + E + +Q+ ++ K + + KL L K E EL + + E EF
Sbjct: 450 EE-RISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQ 508
Query: 870 RSLKA----SERETIKM--------------------------QDKLNQLSEEKATLLNQ 899
+K S+ E +K+ ++KL L +E T +
Sbjct: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR 568
Query: 900 LVEAEHQI--MLWEKKIQLAKEMRSSVDSEIG-------------QTEIRAMKGEIHRMK 944
++E E + L E K Q +K++ +++E +TE+ ++K + +
Sbjct: 569 ILELESSLEKSLQENKNQ-SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALW 627
Query: 945 VRLGQLLKQ--QEKMIRAMELAVARRETVTTQAE-----GQRKMDRKALTRTDFHHKQLE 997
Q+LKQ Q +M + E +ET+ E +M+ K L + D +LE
Sbjct: 628 TEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 687
Query: 998 -LRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEK-QEKLSVIQADFDTL----EADL 1051
L ++ +V KA + + + L++ + L K E+ + Q D++ E +
Sbjct: 688 SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSI 747
Query: 1052 TRLGALKRQNLSEI-VALQTRLKHL---QAVKEGRYVFLFRSKQSLVLERQRLDKRLALI 1107
R + ++++ + L+ R KHL QA E + RS+ L Q+ +L +
Sbjct: 748 QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGEL----QQASAKLDVF 803
Query: 1108 ATILDRVRDEYPQFQEALHKVSQMI 1132
+ ++ ++E L ++ Q +
Sbjct: 804 QSYQSATHEQTKAYEEQLAQLQQKL 828
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 97.1 bits (240), Expect = 9e-20
Identities = 162/824 (19%), Positives = 339/824 (41%), Gaps = 97/824 (11%)
Query: 297 NYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQK-LLEKSHDRHAMA 355
N LN+ KL+ +++L + +Q + R +L N +++ L Q+ +L+ +D+ +
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 356 SSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDI 415
+++ E Q + + + +KK+ LQ +E L
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGL-QFQKKIKELQARIEELE----------------- 1120
Query: 416 RVMTQVVKKAETERI-RAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQY----LAQAED 470
++ E ER RA+ EK++ D Y +L +++LEE + Q +AE
Sbjct: 1121 -------EEIEAERATRAKTEKQRSD-YARELEELSERLEEAGGVTSTQIELNKKREAEF 1172
Query: 471 TRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKST 530
+ LR+ + EA + +A+ R+ + A S+ + + + + V + L + + K
Sbjct: 1173 LK-LRRDLEEATLQHEAMVAALRK---KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1228
Query: 531 DGEIEAYKKSIMKEEEKNEKLASILNRTETEAT----LLQKLTTQCLTKQVALQSQFNTY 586
++ + +S+ K + EK+ L +EA +Q+ ++ T++ LQ++
Sbjct: 1229 IDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL 1288
Query: 587 RLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTT 646
L++ E +SQ + T++ + +++ +LE K A+ LQ +S
Sbjct: 1289 SRQLEEKESIVSQLSRSKQAFTQQTEELKR----QLEEENKAKNALAHALQ---SSRHDC 1341
Query: 647 KYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVN 706
+ Q+ K + LSK N ++AQ T DA Q+T EL++ KK+
Sbjct: 1342 DLLREQYEEEQEGKAELQRALSKANSEVAQW-----RTKYETDAIQRT-EELEEAKKKLA 1395
Query: 707 ELITNSQSEISRRTILI-------ERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRL 759
+ + +S+ ++ +R QG + L +ER S L+ + +
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA-----LDKKQRNF 1450
Query: 760 SKLIDEHDGKAVQAQVTW-------LRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKK 812
K++ E K ++Q L E+ K+ EE L L+ K+E +EQ+
Sbjct: 1451 DKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEI 1510
Query: 813 LRVESKIEQEKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSL 872
+ +I + K E+E K ++ + + + + + + E E + E +
Sbjct: 1511 ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK 1570
Query: 873 KASERETIKMQDKLNQLS-------EEKATLLNQLVEAEHQIMLWEKK---------IQL 916
+R+ + +++ QL E + L+ V + ++ + +KK IQL
Sbjct: 1571 SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630
Query: 917 AKEMRSSVDSEIGQTEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARRETVTTQAE 976
+ R + ++ +R+++G++ ++ L L+ QE + +LA+ R QAE
Sbjct: 1631 SHANRQAAET---LKHLRSVQGQLKDTQLHLDDALRGQEDL--KEQLAIVERRANLLQAE 1685
Query: 977 GQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSSSLLEKQEK 1036
+ R L +T+ K E +++ D + L T++ + + L++ Q +
Sbjct: 1686 VEEL--RATLEQTERARKLAE--QELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSE 1741
Query: 1037 LSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLKHLQAVKE 1080
+ D E + E+ Q HL+ +K+
Sbjct: 1742 VEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Score = 81.6 bits (200), Expect = 4e-15
Identities = 178/891 (19%), Positives = 370/891 (41%), Gaps = 139/891 (15%)
Query: 287 LMVRFQAALKNYLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLE 346
L+ R QA + +L R + + +E + + + R + V + + ++ LL+
Sbjct: 785 LITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNI--RSFMNVKHWPWMKLFFKIKPLLK 842
Query: 347 KSHDRHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN 406
+ MA+ + EE Q + K+ A E +KL L E +L L + Q
Sbjct: 843 SAETEKEMATMK-----EEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQV---QA 894
Query: 407 IDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLA 466
+++ D Q++K + ++E K + ++T RA+ EE A A+
Sbjct: 895 ESENLLDAEERCDQLIKA------KFQLEAK-----IKEVTERAEDEEEINAELTAK--- 940
Query: 467 QAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQ 526
R L SE +ID + + ++ ++ ++ +K+ E + E + +
Sbjct: 941 ----KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTRE 996
Query: 527 AKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTY 586
K+ EA+++++ + + +K+ S LN+T+++ L +QV
Sbjct: 997 KKALQ---EAHQQALDDLQAEEDKVNS-LNKTKSK-----------LEQQV--------- 1032
Query: 587 RLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTT 646
+D E +L Q++ L +L+ ++ ++G+L+L +++
Sbjct: 1033 ----EDLESSLEQEKK----LRVDLERNKRKLEGDLKLAQES------------------ 1066
Query: 647 KYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVN 706
IL L+ +K + L K + + Q + + QK + EL ++++
Sbjct: 1067 ------ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE 1120
Query: 707 ELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKR---LSKLI 763
E I ++E + R +++ L + ER+ E GG +EL KR KL
Sbjct: 1121 EEI---EAERATRAKTEKQRSDYARELEELSERL-EEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 764 DEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVE-----SK 818
+ + +Q + L+++ E EQ+ +L K++L E+ + ++E S
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLE-KEKSEFKLEIDDLSSS 1235
Query: 819 IEQEKKEQKEIEHHMKDLDNDLKKL------------NMLMNKNRCSSEELEQNNRVTEN 866
+E K + +E + L++ L + + K+R +E E + ++ E
Sbjct: 1236 MESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295
Query: 867 EFV-----RSLKASERETIKMQDKLNQLSEEKATLLNQLVEAEHQIMLWEKKIQLAKEMR 921
E + RS +A ++T +++ +L + ++ K L + L + H L ++ + +E +
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 922 -------SSVDSEIGQ------TEIRAMKGEIHRMKVRLGQLLKQQEKMIRAMELAVARR 968
S +SE+ Q T+ E+ K +L Q L+ E+ + A+ A
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 969 ETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECTKTVLELEETQRNVSS 1028
E + +G+ + + R + L+ +K R+ K E KT + EE+Q + +
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALD--KKQRNFDKVLAE-WKT--KCEESQAELEA 1470
Query: 1029 SLLEKQEKLSVIQADFDTLEADLTRLGALKRQ--NLSEIVALQTRLKHLQAVKEGRYVF- 1085
SL E + + + + E L +L +KR+ NL + +A T Q + G+ +
Sbjct: 1471 SLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE----QIAENGKTIHE 1526
Query: 1086 LFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQMIANKL 1136
L +S++ + LE+ + L L+ + + Q L +V I K+
Sbjct: 1527 LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKI 1577
Score = 60.8 bits (146), Expect = 7e-09
Identities = 121/688 (17%), Positives = 265/688 (38%), Gaps = 108/688 (15%)
Query: 247 QIQQPSTEEGAMAERVESEGSD---------EEAEDEGSQLVVLDPDHPLMVRFQAALKN 297
Q+++ + + A+A ++S D EE E + L + + +++ +
Sbjct: 1319 QLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1378
Query: 298 YLNRQIEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEK---SHDRHAM 354
++ E+L+ ++L + S Q + + +++ LQ +E +R
Sbjct: 1379 DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS 1438
Query: 355 ASSERRQKEEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDD 414
++ +K+ A + C E + +L A E +L+ LF ++N ++ D
Sbjct: 1439 LAAALDKKQRNFDKVLAEWKTKC---EESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495
Query: 415 IRVMTQVVKKAE------TERIRAEIEKKKQDLYVDQLTTRAQQLEEDIALFEAQYLAQA 468
+ + + K E TE+I AE K +L + ++ + +AL EA+ +
Sbjct: 1496 LETVKRENKNLEQEIADLTEQI-AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH 1554
Query: 469 EDTRILR--KAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQ 526
E+ +ILR +++ +EID EK ++Q R Q
Sbjct: 1555 EEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLK--------------------RNYQRT 1594
Query: 527 AKSTDGEIEAYKKSIMKEEEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTY 586
++ ++A +S + +K+ LN E + + + + L ++Q Q
Sbjct: 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 1654
Query: 587 RLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTT 646
+L L D +D EQ+ + E + QA EL + R+ ++ + +
Sbjct: 1655 QLHLDDALRG-QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS--- 1710
Query: 647 KYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVELDQDVKKVN 706
N+ + L + T+++ K+ D+ Q ++ S +D +
Sbjct: 1711 ---NERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS--------------RDARNAE 1753
Query: 707 ELITNSQSEISRRTILIERKQGLINFLNKQLERMVSELGGEEVGPLELEIKRLSKLIDEH 766
E + ++ + ++++Q + LERM L E +K L +DE
Sbjct: 1754 EKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNL--------EQTVKDLQHRLDE- 1800
Query: 767 DGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQ 826
EQLA L KK++ +E + +E ++E E+K+
Sbjct: 1801 -------------------------AEQLA-LKGGKKQIQKLETRIRELEFELEGEQKKN 1834
Query: 827 KEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKL 886
E ++ + +K+L ++R + L+ ++ +K+ +R+ + ++
Sbjct: 1835 TESVKGLRKYERRVKELTYQSEEDRKNVLRLQD----LVDKLQVKVKSYKRQAEEADEQA 1890
Query: 887 NQLSEEKATLLNQLVEAEHQIMLWEKKI 914
N + ++L EAE + + E ++
Sbjct: 1891 NAHLTKFRKAQHELEEAEERADIAESQV 1918
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 97.1 bits (240), Expect = 9e-20
Identities = 193/971 (19%), Positives = 378/971 (38%), Gaps = 125/971 (12%)
Query: 245 QDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIE 304
QD+ Q+ E +A RV++E E A ++ L L+ L ++ + A + ++E
Sbjct: 1504 QDESQRKRQAEVELASRVKAEA--EAAREKQRALQALEE---LRLQAEEAERRLRQAEVE 1558
Query: 305 KLKLDLQELVVATKQSRAQRQELGVNLYE--------VQQHLVHLQKLLEKSHDRHAMAS 356
+ + L A + + A+ Q + E +Q+ V + +L E++ R +
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 357 SERRQKEE--------ELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN-- 406
R +EE +L+A AL + A ++K LA + E + +
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 407 -IDQDMRD------DIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIAL 459
+Q +R ++ Q+ + +R+ AE E + +Q + Q LEE++A
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738
Query: 460 FEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAH----RA 515
+ + A + + L +++ E++ + K R ++ S+ K R EA R
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 516 VLEA---LRGCQHQAKSTD--GEIEAYKKSIMKEEEKNEKLASILN----RTETEATLLQ 566
+ E LR +AK E +A ++ E EKLA+I +TE E L +
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 567 KLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRR 626
K +++A F RL E+ +Q + + + E L +R+A ELE ++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRL-----EEQAAQHKAD---IEERLAQLRKASDSELERQK 1910
Query: 627 KTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS 686
+ + L++ + + K + L +I + A+ TL +
Sbjct: 1911 ---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN-AEDTLRSKEQAE 1966
Query: 687 RLDAHQKTLV--------ELDQDVKKVNELITNSQSEISRRTIL--IERKQGLINFLNKQ 736
A Q+ L E ++ V+K L ++ R+ L +ER + + +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 737 LERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLA 796
ER E + E KRL H AVQ + +QE+ + Q+++ L
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAH-AFAVQQK------EQELQQTLQQEQSVLD 2077
Query: 797 SL----DASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLK---KLNMLMNK 849
L +A+++ E+ +++ E + Q +++ +E E + + + + K
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 850 NRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKA-------TLLNQLVE 902
R +E+ E +R +A++ E K + Q +KA TL QL E
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 903 AEHQIMLWEKKIQLAK-------EMRSSVDSEIGQTEIRAMKGEIHRMKVRL-----GQL 950
+HQ L ++++Q K RS V+ E+ +R E+ ++K R+ +
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEEL--FSVRVQMEELSKLKARIEAENRALI 2255
Query: 951 LKQQEKMIRAMELAVARRETVTTQA-----EGQRKMDRKALTRTDFHHKQLELRRKIRDV 1005
L+ ++ R ++ + + V +A Q + L D ++ + +++
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 1006 RKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEI 1065
+A E T+ E E LL++Q++L+ QA RL K Q ++
Sbjct: 2316 MQAVQEATRLKAEAE---------LLQQQKELAQEQA---------RRLQEDKEQMAQQL 2357
Query: 1066 VALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEAL 1125
+ + R + + + L L + + A R R + + E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1126 HKVSQMIANKL 1136
H+ K+
Sbjct: 2418 HRTELATQEKV 2428
Score = 94.4 bits (233), Expect = 6e-19
Identities = 224/1110 (20%), Positives = 445/1110 (40%), Gaps = 112/1110 (10%)
Query: 42 KGEEAVGSTEHPEEVTTQ---AEAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYT 98
K EA+ EEV Q A+A E+ + E E EA G+ E + E E+
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 99 ETSSPEGQISAADTTYPYFSPPQEL--------PGEEAYDSVSGE-AGLQGFQQEATGPP 149
+ EG T + QEL GE+ + E A LQ AT
Sbjct: 1697 QRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 150 ESRERRVTSPEPSHGVLGPS----EQMGQVTSGPAVGRLTGST--------EEPQGQVLP 197
+ E + VL S E+ + TS + RL E + + L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 198 MGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ-----DQIQQPS 252
+ + +L+ E V E + G E ++ + + +++++ +
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 253 TEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQE 312
+E R+E + + +A+ E +L L + Q L RQ +++ ++
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 313 LVVATKQSRAQRQELGVNLYEVQQHLVHL-----QKLLEKSHDRHAMASSERRQKEEELQ 367
L + +++ A + EL + L ++ + Q LE + R A ERR++E E +
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 368 AARALYTKTCAAANEE--RKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKA 425
++L AA EE R++ AAL+ E+E L + + + + + Q+ ++A
Sbjct: 1990 VQKSL------AAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 426 ETERIRAEIEKKKQDLYVDQLTTRAQQ-LEEDIALFEAQYLAQAEDTRILRKAVSEACTE 484
+R++AE +K V Q QQ L+++ ++ + Q +AE R + EA +
Sbjct: 2043 AQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLD-QLRGEAEAARRAAEEAEEARVQ 2099
Query: 485 IDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKE 544
+ + + RR +++ A L + +E +A +A + K + E EA +++ ++
Sbjct: 2100 AEREAAQSRRQVEE-AERL--KQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQ 2154
Query: 545 EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQ-DQLE 603
+K A+ + E +K Q L ++ ++ + T RL L++T+ + D+
Sbjct: 2155 AALRQKQAA-----DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209
Query: 604 QMILTEELQAIRQAIQGELEL-----RRKTDAAIREKLQ-EHMTSNKTTKYFNQLILRLQ 657
Q + E +A RQ Q E EL + + + ++ +++ E+ K Q L+ +
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2269
Query: 658 KEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVE--LDQDVKKVNELITNSQSE 715
EK + + AQ + + A Q+ L E L + ++ V E T ++E
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-TRLKAE 2328
Query: 716 ISRRTILIERKQGLINFLNKQLERMVSELGGEEVG---PLELEIKRLSKLIDEHDGKAVQ 772
E Q L + E+M +L E G LE E +R ++ E +
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE----- 2383
Query: 773 AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHH 832
RL+ + ++++ Q +K+ + +K R E +++ + +E
Sbjct: 2384 ------RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 833 MKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEE 892
+ D+D ++L + + E+L+Q ++ + LK+ E +T++ + QL +E
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE----QLLQE 2487
Query: 893 KATLLNQLVEAEHQIMLWEKKIQLAK-EMRSSVDSEIGQT-----EIRAMKGEIHRMKVR 946
L + + ++ E+ I+ K ++ E+ + E + + ++ + + R
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 947 LGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFH-HKQLE-LRRKIRD 1004
L +++ + E V R++ Q E QR+ + L + +QL+ L + R
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 1005 VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEAD-----LTRLGALKR 1059
++E T + + +T N L+ + + FD L L G L
Sbjct: 2608 ALAHSEEVTASQVAATKTLPN-GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2666
Query: 1060 QNLSEIVALQTRLKHLQAVKEGRYVFLFRS 1089
+ L + T + L ++ R+ RS
Sbjct: 2667 EELQRLAQGHTTVDELARREDVRHYLQGRS 2696
Score = 87.8 bits (216), Expect = 5e-17
Identities = 192/957 (20%), Positives = 382/957 (39%), Gaps = 162/957 (16%)
Query: 245 QDQIQ-QPSTEEGAMAERVESEGSD-EEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQ 302
Q+QIQ P + A+ E++ E + EE E G ++ + ++ A+K+Y Q
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV---EECQRFAKQYINAIKDY-ELQ 1285
Query: 303 IEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQK 362
+ K L+ + K+ + Q V + E H +L + S R+
Sbjct: 1286 LVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 363 EEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVV 422
EEE + A EER++LA ++ +E R Q
Sbjct: 1345 EEEERLAEQQRA-------EERERLAEVEAALEK--------------QRQLAEAHAQA- 1382
Query: 423 KKAETERIRAEIEKKKQDLYV--DQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSE 480
KA+ ER E++++ Q+ V ++ AQQ + I E Q L Q+ + I KA
Sbjct: 1383 -KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKARQA 1440
Query: 481 ACTEIDAISVEKR-RIMQQWASSLVGMKHRDEAHRAVLEALRG----CQHQAKSTDGEIE 535
E + +E+ R+++ L + + L+ALR + Q + E E
Sbjct: 1441 EAAERSRLRIEEEIRVVRL---QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 536 AYKKSIMKEEE-KNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTE 594
++ + E + K + + +R + EA ++ KQ ALQ+ RL ++ E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-------KQRALQA-LEELRLQAEEAE 1549
Query: 595 DALSQDQLEQMILTE-ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLI 653
L Q ++E+ + L+ +++ + EL+ +R + A +L+ + ++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE----EHVAVAQ 1605
Query: 654 LRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS------RLDAH----QKTLVELDQDVK 703
LR + E+ ++ + A+ L+ + RL A QK+L + + + +
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 704 KVNELITNSQSEISRRTILIERKQGLINFLNKQLE--RMVSELGGEEVGPLELEIKRLSK 761
K ++ E RR E+ ++LE R ++E ++ E E+ RL
Sbjct: 1666 K-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 762 LIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQ 821
++ + + + RLQ+E TQ+++E A L + E+ ++ K R E E+
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EE 1777
Query: 822 EKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASER---- 877
+ ++ + ++ ++L + R +EE ++ ++ E + R +ER
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 878 --------------------ETIKMQDKLNQLSEEKATLLNQLVE--AEHQIMLWEKKIQ 915
E ++L +L+E++A +L E A+H+ + E+ Q
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 916 LAKEMRSSVDSEIG------------QTEIRAMKGEIHR-------MKVRLGQLLKQQEK 956
L K S ++ + G + EI A+K + +++ LG++ E
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 957 MIRA---MELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECT 1013
+R+ EL AR+ + + E +R+ + + ++ ++ +RK A +E
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVE 2012
Query: 1014 KTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLK 1073
+ ++EE +R L E+ E+ S Q +A + K
Sbjct: 2013 RLKAKVEEARR-----LRERAEQESARQLQ----------------------LAQEAAQK 2045
Query: 1074 HLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQ 1130
LQA +E + F + K+ Q L + L ++LD++R E + A + +
Sbjct: 2046 RLQA-EEKAHAFAVQQKE------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Score = 44.7 bits (104), Expect = 5e-04
Identities = 125/574 (21%), Positives = 230/574 (40%), Gaps = 91/574 (15%)
Query: 18 ASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQAEAAIEEGEVETEGEAAV 77
A+E +E ++ + + ++ E S E + QA+AA E+ E E EAA
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 78 EGEEEAVSY-----GDAESEEEYYYTE-TSSPEGQISAADTTYPYFSPPQELPGEEAYDS 131
+ E + DAE E+ + E T + Q+ TT +L + +
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-----QLEETDHQKN 2203
Query: 132 VSGEAGLQGFQQEATGPPESR---ERRVTSPEPSHGVLGPSEQMGQVTSGPAVGRLTGST 188
+ E LQ + EAT R E + S L + + + + R +T
Sbjct: 2204 LLDEE-LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 189 E---EPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ 245
+ + + + + + RLS + E++ L + ++ + + +E +
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKMLKE------K 2315
Query: 246 DQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVR--------FQAALKN 297
Q Q +T A AE ++ + E A+++ + L D M + FQ L+
Sbjct: 2316 MQAVQEATRLKAEAELLQQQ--KELAQEQARR---LQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 298 YLNRQI------EKLKLDLQELVVA-------TKQSRAQRQELGVNLYEVQ---QHLVHL 341
RQ+ E+LKL + E+ A ++ R Q +E+G L+ + Q V L
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 342 QKLLE-----KSHD----RHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT 392
+ LE HD R A+A E R+KE+ Q A+ L K +EE + + Q
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELE-REKEKLQQEAKLLQLK-----SEEMQTVQQEQL 2484
Query: 393 EMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQ 452
E AL ++ D ++ + R + Q +KA+ E++ + K Q L +Q + QQ
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRE-RFIEQ--EKAKLEQLFQDEVAKAQQLREEQ-QRQQQQ 2540
Query: 453 LEEDIALFEAQYLAQAEDTRILRKAVSEAC----TEIDAISVEKRRIMQQWASSLVGMKH 508
+E++ + +A E+ R + E E+ + ++R+ + A ++
Sbjct: 2541 MEQE----RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Query: 509 R----DEAHRAVLEALRGCQHQAKSTDGEIEAYK 538
+ +E HRA L H + T ++ A K
Sbjct: 2597 QLQLLEEQHRAAL------AHSEEVTASQVAATK 2624
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 97.1 bits (240), Expect = 9e-20
Identities = 193/971 (19%), Positives = 378/971 (38%), Gaps = 125/971 (12%)
Query: 245 QDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIE 304
QD+ Q+ E +A RV++E E A ++ L L+ L ++ + A + ++E
Sbjct: 1508 QDESQRKRQAEVELASRVKAEA--EAAREKQRALQALEE---LRLQAEEAERRLRQAEVE 1562
Query: 305 KLKLDLQELVVATKQSRAQRQELGVNLYE--------VQQHLVHLQKLLEKSHDRHAMAS 356
+ + L A + + A+ Q + E +Q+ V + +L E++ R +
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622
Query: 357 SERRQKEE--------ELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN-- 406
R +EE +L+A AL + A ++K LA + E + +
Sbjct: 1623 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1682
Query: 407 -IDQDMRD------DIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIAL 459
+Q +R ++ Q+ + +R+ AE E + +Q + Q LEE++A
Sbjct: 1683 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1742
Query: 460 FEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAH----RA 515
+ + A + + L +++ E++ + K R ++ S+ K R EA R
Sbjct: 1743 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802
Query: 516 VLEA---LRGCQHQAKSTD--GEIEAYKKSIMKEEEKNEKLASILN----RTETEATLLQ 566
+ E LR +AK E +A ++ E EKLA+I +TE E L +
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862
Query: 567 KLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRR 626
K +++A F RL E+ +Q + + + E L +R+A ELE ++
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRL-----EEQAAQHKAD---IEERLAQLRKASDSELERQK 1914
Query: 627 KTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS 686
+ + L++ + + K + L +I + A+ TL +
Sbjct: 1915 ---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN-AEDTLRSKEQAE 1970
Query: 687 RLDAHQKTLV--------ELDQDVKKVNELITNSQSEISRRTIL--IERKQGLINFLNKQ 736
A Q+ L E ++ V+K L ++ R+ L +ER + + +
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRL 2028
Query: 737 LERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLA 796
ER E + E KRL H AVQ + +QE+ + Q+++ L
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAH-AFAVQQK------EQELQQTLQQEQSVLD 2081
Query: 797 SL----DASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLK---KLNMLMNK 849
L +A+++ E+ +++ E + Q +++ +E E + + + + K
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 850 NRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKA-------TLLNQLVE 902
R +E+ E +R +A++ E K + Q +KA TL QL E
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 903 AEHQIMLWEKKIQLAK-------EMRSSVDSEIGQTEIRAMKGEIHRMKVRL-----GQL 950
+HQ L ++++Q K RS V+ E+ +R E+ ++K R+ +
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEEL--FSVRVQMEELSKLKARIEAENRALI 2259
Query: 951 LKQQEKMIRAMELAVARRETVTTQA-----EGQRKMDRKALTRTDFHHKQLELRRKIRDV 1005
L+ ++ R ++ + + V +A Q + L D ++ + +++
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2319
Query: 1006 RKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEI 1065
+A E T+ E E LL++Q++L+ QA RL K Q ++
Sbjct: 2320 MQAVQEATRLKAEAE---------LLQQQKELAQEQA---------RRLQEDKEQMAQQL 2361
Query: 1066 VALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEAL 1125
+ + R + + + L L + + A R R + + E L
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 1126 HKVSQMIANKL 1136
H+ K+
Sbjct: 2422 HRTELATQEKV 2432
Score = 94.4 bits (233), Expect = 6e-19
Identities = 224/1110 (20%), Positives = 445/1110 (40%), Gaps = 112/1110 (10%)
Query: 42 KGEEAVGSTEHPEEVTTQ---AEAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYT 98
K EA+ EEV Q A+A E+ + E E EA G+ E + E E+
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1700
Query: 99 ETSSPEGQISAADTTYPYFSPPQEL--------PGEEAYDSVSGE-AGLQGFQQEATGPP 149
+ EG T + QEL GE+ + E A LQ AT
Sbjct: 1701 QRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 150 ESRERRVTSPEPSHGVLGPS----EQMGQVTSGPAVGRLTGST--------EEPQGQVLP 197
+ E + VL S E+ + TS + RL E + + L
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814
Query: 198 MGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ-----DQIQQPS 252
+ + +L+ E V E + G E ++ + + +++++ +
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874
Query: 253 TEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQE 312
+E R+E + + +A+ E +L L + Q L RQ +++ ++
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933
Query: 313 LVVATKQSRAQRQELGVNLYEVQQHLVHL-----QKLLEKSHDRHAMASSERRQKEEELQ 367
L + +++ A + EL + L ++ + Q LE + R A ERR++E E +
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993
Query: 368 AARALYTKTCAAANEE--RKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKA 425
++L AA EE R++ AAL+ E+E L + + + + + Q+ ++A
Sbjct: 1994 VQKSL------AAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 426 ETERIRAEIEKKKQDLYVDQLTTRAQQ-LEEDIALFEAQYLAQAEDTRILRKAVSEACTE 484
+R++AE +K V Q QQ L+++ ++ + Q +AE R + EA +
Sbjct: 2047 AQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLD-QLRGEAEAARRAAEEAEEARVQ 2103
Query: 485 IDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKE 544
+ + + RR +++ A L + +E +A +A + K + E EA +++ ++
Sbjct: 2104 AEREAAQSRRQVEE-AERL--KQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQ 2158
Query: 545 EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQ-DQLE 603
+K A+ + E +K Q L ++ ++ + T RL L++T+ + D+
Sbjct: 2159 AALRQKQAA-----DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2213
Query: 604 QMILTEELQAIRQAIQGELEL-----RRKTDAAIREKLQ-EHMTSNKTTKYFNQLILRLQ 657
Q + E +A RQ Q E EL + + + ++ +++ E+ K Q L+ +
Sbjct: 2214 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2273
Query: 658 KEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVE--LDQDVKKVNELITNSQSE 715
EK + + AQ + + A Q+ L E L + ++ V E T ++E
Sbjct: 2274 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-TRLKAE 2332
Query: 716 ISRRTILIERKQGLINFLNKQLERMVSELGGEEVG---PLELEIKRLSKLIDEHDGKAVQ 772
E Q L + E+M +L E G LE E +R ++ E +
Sbjct: 2333 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE----- 2387
Query: 773 AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHH 832
RL+ + ++++ Q +K+ + +K R E +++ + +E
Sbjct: 2388 ------RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2441
Query: 833 MKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEE 892
+ D+D ++L + + E+L+Q ++ + LK+ E +T++ + QL +E
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE----QLLQE 2491
Query: 893 KATLLNQLVEAEHQIMLWEKKIQLAK-EMRSSVDSEIGQT-----EIRAMKGEIHRMKVR 946
L + + ++ E+ I+ K ++ E+ + E + + ++ + + R
Sbjct: 2492 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551
Query: 947 LGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFH-HKQLE-LRRKIRD 1004
L +++ + E V R++ Q E QR+ + L + +QL+ L + R
Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611
Query: 1005 VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEAD-----LTRLGALKR 1059
++E T + + +T N L+ + + FD L L G L
Sbjct: 2612 ALAHSEEVTASQVAATKTLPN-GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2670
Query: 1060 QNLSEIVALQTRLKHLQAVKEGRYVFLFRS 1089
+ L + T + L ++ R+ RS
Sbjct: 2671 EELQRLAQGHTTVDELARREDVRHYLQGRS 2700
Score = 87.8 bits (216), Expect = 5e-17
Identities = 192/957 (20%), Positives = 382/957 (39%), Gaps = 162/957 (16%)
Query: 245 QDQIQ-QPSTEEGAMAERVESEGSD-EEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQ 302
Q+QIQ P + A+ E++ E + EE E G ++ + ++ A+K+Y Q
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV---EECQRFAKQYINAIKDY-ELQ 1289
Query: 303 IEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQK 362
+ K L+ + K+ + Q V + E H +L + S R+
Sbjct: 1290 LVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 363 EEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVV 422
EEE + A EER++LA ++ +E R Q
Sbjct: 1349 EEEERLAEQQRA-------EERERLAEVEAALEK--------------QRQLAEAHAQA- 1386
Query: 423 KKAETERIRAEIEKKKQDLYV--DQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSE 480
KA+ ER E++++ Q+ V ++ AQQ + I E Q L Q+ + I KA
Sbjct: 1387 -KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKARQA 1444
Query: 481 ACTEIDAISVEKR-RIMQQWASSLVGMKHRDEAHRAVLEALRG----CQHQAKSTDGEIE 535
E + +E+ R+++ L + + L+ALR + Q + E E
Sbjct: 1445 EAAERSRLRIEEEIRVVRL---QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501
Query: 536 AYKKSIMKEEE-KNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTE 594
++ + E + K + + +R + EA ++ KQ ALQ+ RL ++ E
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-------KQRALQA-LEELRLQAEEAE 1553
Query: 595 DALSQDQLEQMILTE-ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLI 653
L Q ++E+ + L+ +++ + EL+ +R + A +L+ + ++
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE----EHVAVAQ 1609
Query: 654 LRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS------RLDAH----QKTLVELDQDVK 703
LR + E+ ++ + A+ L+ + RL A QK+L + + + +
Sbjct: 1610 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
Query: 704 KVNELITNSQSEISRRTILIERKQGLINFLNKQLE--RMVSELGGEEVGPLELEIKRLSK 761
K ++ E RR E+ ++LE R ++E ++ E E+ RL
Sbjct: 1670 K-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1724
Query: 762 LIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQ 821
++ + + + RLQ+E TQ+++E A L + E+ ++ K R E E+
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EE 1781
Query: 822 EKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASER---- 877
+ ++ + ++ ++L + R +EE ++ ++ E + R +ER
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841
Query: 878 --------------------ETIKMQDKLNQLSEEKATLLNQLVE--AEHQIMLWEKKIQ 915
E ++L +L+E++A +L E A+H+ + E+ Q
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901
Query: 916 LAKEMRSSVDSEIG------------QTEIRAMKGEIHR-------MKVRLGQLLKQQEK 956
L K S ++ + G + EI A+K + +++ LG++ E
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961
Query: 957 MIRA---MELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECT 1013
+R+ EL AR+ + + E +R+ + + ++ ++ +RK A +E
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVE 2016
Query: 1014 KTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLK 1073
+ ++EE +R L E+ E+ S Q +A + K
Sbjct: 2017 RLKAKVEEARR-----LRERAEQESARQLQ----------------------LAQEAAQK 2049
Query: 1074 HLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQ 1130
LQA +E + F + K+ Q L + L ++LD++R E + A + +
Sbjct: 2050 RLQA-EEKAHAFAVQQKE------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Score = 44.7 bits (104), Expect = 5e-04
Identities = 125/574 (21%), Positives = 230/574 (40%), Gaps = 91/574 (15%)
Query: 18 ASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQAEAAIEEGEVETEGEAAV 77
A+E +E ++ + + ++ E S E + QA+AA E+ E E EAA
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Query: 78 EGEEEAVSY-----GDAESEEEYYYTE-TSSPEGQISAADTTYPYFSPPQELPGEEAYDS 131
+ E + DAE E+ + E T + Q+ TT +L + +
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-----QLEETDHQKN 2207
Query: 132 VSGEAGLQGFQQEATGPPESR---ERRVTSPEPSHGVLGPSEQMGQVTSGPAVGRLTGST 188
+ E LQ + EAT R E + S L + + + + R +T
Sbjct: 2208 LLDEE-LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2266
Query: 189 E---EPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ 245
+ + + + + + RLS + E++ L + ++ + + +E +
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKMLKE------K 2319
Query: 246 DQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVR--------FQAALKN 297
Q Q +T A AE ++ + E A+++ + L D M + FQ L+
Sbjct: 2320 MQAVQEATRLKAEAELLQQQ--KELAQEQARR---LQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 298 YLNRQI------EKLKLDLQELVVA-------TKQSRAQRQELGVNLYEVQ---QHLVHL 341
RQ+ E+LKL + E+ A ++ R Q +E+G L+ + Q V L
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 342 QKLLE-----KSHD----RHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT 392
+ LE HD R A+A E R+KE+ Q A+ L K +EE + + Q
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELE-REKEKLQQEAKLLQLK-----SEEMQTVQQEQL 2488
Query: 393 EMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQ 452
E AL ++ D ++ + R + Q +KA+ E++ + K Q L +Q + QQ
Sbjct: 2489 LQETQALQQSFLSEKDSLLQRE-RFIEQ--EKAKLEQLFQDEVAKAQQLREEQ-QRQQQQ 2544
Query: 453 LEEDIALFEAQYLAQAEDTRILRKAVSEAC----TEIDAISVEKRRIMQQWASSLVGMKH 508
+E++ + +A E+ R + E E+ + ++R+ + A ++
Sbjct: 2545 MEQE----RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2600
Query: 509 R----DEAHRAVLEALRGCQHQAKSTDGEIEAYK 538
+ +E HRA L H + T ++ A K
Sbjct: 2601 QLQLLEEQHRAAL------AHSEEVTASQVAATK 2628
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 97.1 bits (240), Expect = 9e-20
Identities = 193/971 (19%), Positives = 378/971 (38%), Gaps = 125/971 (12%)
Query: 245 QDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIE 304
QD+ Q+ E +A RV++E E A ++ L L+ L ++ + A + ++E
Sbjct: 1504 QDESQRKRQAEVELASRVKAEA--EAAREKQRALQALEE---LRLQAEEAERRLRQAEVE 1558
Query: 305 KLKLDLQELVVATKQSRAQRQELGVNLYE--------VQQHLVHLQKLLEKSHDRHAMAS 356
+ + L A + + A+ Q + E +Q+ V + +L E++ R +
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 357 SERRQKEE--------ELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN-- 406
R +EE +L+A AL + A ++K LA + E + +
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 407 -IDQDMRD------DIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIAL 459
+Q +R ++ Q+ + +R+ AE E + +Q + Q LEE++A
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1738
Query: 460 FEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAH----RA 515
+ + A + + L +++ E++ + K R ++ S+ K R EA R
Sbjct: 1739 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 516 VLEA---LRGCQHQAKSTD--GEIEAYKKSIMKEEEKNEKLASILN----RTETEATLLQ 566
+ E LR +AK E +A ++ E EKLA+I +TE E L +
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 567 KLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRR 626
K +++A F RL E+ +Q + + + E L +R+A ELE ++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRL-----EEQAAQHKAD---IEERLAQLRKASDSELERQK 1910
Query: 627 KTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS 686
+ + L++ + + K + L +I + A+ TL +
Sbjct: 1911 ---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN-AEDTLRSKEQAE 1966
Query: 687 RLDAHQKTLV--------ELDQDVKKVNELITNSQSEISRRTIL--IERKQGLINFLNKQ 736
A Q+ L E ++ V+K L ++ R+ L +ER + + +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 737 LERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLA 796
ER E + E KRL H AVQ + +QE+ + Q+++ L
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAH-AFAVQQK------EQELQQTLQQEQSVLD 2077
Query: 797 SL----DASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLK---KLNMLMNK 849
L +A+++ E+ +++ E + Q +++ +E E + + + + K
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 850 NRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKA-------TLLNQLVE 902
R +E+ E +R +A++ E K + Q +KA TL QL E
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 903 AEHQIMLWEKKIQLAK-------EMRSSVDSEIGQTEIRAMKGEIHRMKVRL-----GQL 950
+HQ L ++++Q K RS V+ E+ +R E+ ++K R+ +
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEEL--FSVRVQMEELSKLKARIEAENRALI 2255
Query: 951 LKQQEKMIRAMELAVARRETVTTQA-----EGQRKMDRKALTRTDFHHKQLELRRKIRDV 1005
L+ ++ R ++ + + V +A Q + L D ++ + +++
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 1006 RKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEI 1065
+A E T+ E E LL++Q++L+ QA RL K Q ++
Sbjct: 2316 MQAVQEATRLKAEAE---------LLQQQKELAQEQA---------RRLQEDKEQMAQQL 2357
Query: 1066 VALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEAL 1125
+ + R + + + L L + + A R R + + E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1126 HKVSQMIANKL 1136
H+ K+
Sbjct: 2418 HRTELATQEKV 2428
Score = 94.4 bits (233), Expect = 6e-19
Identities = 224/1110 (20%), Positives = 445/1110 (40%), Gaps = 112/1110 (10%)
Query: 42 KGEEAVGSTEHPEEVTTQ---AEAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYT 98
K EA+ EEV Q A+A E+ + E E EA G+ E + E E+
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 99 ETSSPEGQISAADTTYPYFSPPQEL--------PGEEAYDSVSGE-AGLQGFQQEATGPP 149
+ EG T + QEL GE+ + E A LQ AT
Sbjct: 1697 QRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 150 ESRERRVTSPEPSHGVLGPS----EQMGQVTSGPAVGRLTGST--------EEPQGQVLP 197
+ E + VL S E+ + TS + RL E + + L
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 198 MGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ-----DQIQQPS 252
+ + +L+ E V E + G E ++ + + +++++ +
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 253 TEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQE 312
+E R+E + + +A+ E +L L + Q L RQ +++ ++
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929
Query: 313 LVVATKQSRAQRQELGVNLYEVQQHLVHL-----QKLLEKSHDRHAMASSERRQKEEELQ 367
L + +++ A + EL + L ++ + Q LE + R A ERR++E E +
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 368 AARALYTKTCAAANEE--RKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKA 425
++L AA EE R++ AAL+ E+E L + + + + + Q+ ++A
Sbjct: 1990 VQKSL------AAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 426 ETERIRAEIEKKKQDLYVDQLTTRAQQ-LEEDIALFEAQYLAQAEDTRILRKAVSEACTE 484
+R++AE +K V Q QQ L+++ ++ + Q +AE R + EA +
Sbjct: 2043 AQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLD-QLRGEAEAARRAAEEAEEARVQ 2099
Query: 485 IDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKE 544
+ + + RR +++ A L + +E +A +A + K + E EA +++ ++
Sbjct: 2100 AEREAAQSRRQVEE-AERL--KQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQ 2154
Query: 545 EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQ-DQLE 603
+K A+ + E +K Q L ++ ++ + T RL L++T+ + D+
Sbjct: 2155 AALRQKQAA-----DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209
Query: 604 QMILTEELQAIRQAIQGELEL-----RRKTDAAIREKLQ-EHMTSNKTTKYFNQLILRLQ 657
Q + E +A RQ Q E EL + + + ++ +++ E+ K Q L+ +
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2269
Query: 658 KEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVE--LDQDVKKVNELITNSQSE 715
EK + + AQ + + A Q+ L E L + ++ V E T ++E
Sbjct: 2270 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-TRLKAE 2328
Query: 716 ISRRTILIERKQGLINFLNKQLERMVSELGGEEVG---PLELEIKRLSKLIDEHDGKAVQ 772
E Q L + E+M +L E G LE E +R ++ E +
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE----- 2383
Query: 773 AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHH 832
RL+ + ++++ Q +K+ + +K R E +++ + +E
Sbjct: 2384 ------RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 833 MKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEE 892
+ D+D ++L + + E+L+Q ++ + LK+ E +T++ + QL +E
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE----QLLQE 2487
Query: 893 KATLLNQLVEAEHQIMLWEKKIQLAK-EMRSSVDSEIGQT-----EIRAMKGEIHRMKVR 946
L + + ++ E+ I+ K ++ E+ + E + + ++ + + R
Sbjct: 2488 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 947 LGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFH-HKQLE-LRRKIRD 1004
L +++ + E V R++ Q E QR+ + L + +QL+ L + R
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 1005 VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEAD-----LTRLGALKR 1059
++E T + + +T N L+ + + FD L L G L
Sbjct: 2608 ALAHSEEVTASQVAATKTLPN-GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2666
Query: 1060 QNLSEIVALQTRLKHLQAVKEGRYVFLFRS 1089
+ L + T + L ++ R+ RS
Sbjct: 2667 EELQRLAQGHTTVDELARREDVRHYLQGRS 2696
Score = 87.8 bits (216), Expect = 5e-17
Identities = 192/957 (20%), Positives = 382/957 (39%), Gaps = 162/957 (16%)
Query: 245 QDQIQ-QPSTEEGAMAERVESEGSD-EEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQ 302
Q+QIQ P + A+ E++ E + EE E G ++ + ++ A+K+Y Q
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV---EECQRFAKQYINAIKDY-ELQ 1285
Query: 303 IEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQK 362
+ K L+ + K+ + Q V + E H +L + S R+
Sbjct: 1286 LVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 363 EEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVV 422
EEE + A EER++LA ++ +E R Q
Sbjct: 1345 EEEERLAEQQRA-------EERERLAEVEAALEK--------------QRQLAEAHAQA- 1382
Query: 423 KKAETERIRAEIEKKKQDLYV--DQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSE 480
KA+ ER E++++ Q+ V ++ AQQ + I E Q L Q+ + I KA
Sbjct: 1383 -KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKARQA 1440
Query: 481 ACTEIDAISVEKR-RIMQQWASSLVGMKHRDEAHRAVLEALRG----CQHQAKSTDGEIE 535
E + +E+ R+++ L + + L+ALR + Q + E E
Sbjct: 1441 EAAERSRLRIEEEIRVVRL---QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 536 AYKKSIMKEEE-KNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTE 594
++ + E + K + + +R + EA ++ KQ ALQ+ RL ++ E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-------KQRALQA-LEELRLQAEEAE 1549
Query: 595 DALSQDQLEQMILTE-ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLI 653
L Q ++E+ + L+ +++ + EL+ +R + A +L+ + ++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE----EHVAVAQ 1605
Query: 654 LRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS------RLDAH----QKTLVELDQDVK 703
LR + E+ ++ + A+ L+ + RL A QK+L + + + +
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 704 KVNELITNSQSEISRRTILIERKQGLINFLNKQLE--RMVSELGGEEVGPLELEIKRLSK 761
K ++ E RR E+ ++LE R ++E ++ E E+ RL
Sbjct: 1666 K-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720
Query: 762 LIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQ 821
++ + + + RLQ+E TQ+++E A L + E+ ++ K R E E+
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EE 1777
Query: 822 EKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASER---- 877
+ ++ + ++ ++L + R +EE ++ ++ E + R +ER
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 878 --------------------ETIKMQDKLNQLSEEKATLLNQLVE--AEHQIMLWEKKIQ 915
E ++L +L+E++A +L E A+H+ + E+ Q
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897
Query: 916 LAKEMRSSVDSEIG------------QTEIRAMKGEIHR-------MKVRLGQLLKQQEK 956
L K S ++ + G + EI A+K + +++ LG++ E
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 957 MIRA---MELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECT 1013
+R+ EL AR+ + + E +R+ + + ++ ++ +RK A +E
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVE 2012
Query: 1014 KTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLK 1073
+ ++EE +R L E+ E+ S Q +A + K
Sbjct: 2013 RLKAKVEEARR-----LRERAEQESARQLQ----------------------LAQEAAQK 2045
Query: 1074 HLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQ 1130
LQA +E + F + K+ Q L + L ++LD++R E + A + +
Sbjct: 2046 RLQA-EEKAHAFAVQQKE------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Score = 44.7 bits (104), Expect = 5e-04
Identities = 125/574 (21%), Positives = 230/574 (40%), Gaps = 91/574 (15%)
Query: 18 ASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQAEAAIEEGEVETEGEAAV 77
A+E +E ++ + + ++ E S E + QA+AA E+ E E EAA
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Query: 78 EGEEEAVSY-----GDAESEEEYYYTE-TSSPEGQISAADTTYPYFSPPQELPGEEAYDS 131
+ E + DAE E+ + E T + Q+ TT +L + +
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-----QLEETDHQKN 2203
Query: 132 VSGEAGLQGFQQEATGPPESR---ERRVTSPEPSHGVLGPSEQMGQVTSGPAVGRLTGST 188
+ E LQ + EAT R E + S L + + + + R +T
Sbjct: 2204 LLDEE-LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 189 E---EPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ 245
+ + + + + + RLS + E++ L + ++ + + +E +
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKMLKE------K 2315
Query: 246 DQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVR--------FQAALKN 297
Q Q +T A AE ++ + E A+++ + L D M + FQ L+
Sbjct: 2316 MQAVQEATRLKAEAELLQQQ--KELAQEQARR---LQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 298 YLNRQI------EKLKLDLQELVVA-------TKQSRAQRQELGVNLYEVQ---QHLVHL 341
RQ+ E+LKL + E+ A ++ R Q +E+G L+ + Q V L
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 342 QKLLE-----KSHD----RHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT 392
+ LE HD R A+A E R+KE+ Q A+ L K +EE + + Q
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELE-REKEKLQQEAKLLQLK-----SEEMQTVQQEQL 2484
Query: 393 EMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQ 452
E AL ++ D ++ + R + Q +KA+ E++ + K Q L +Q + QQ
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRE-RFIEQ--EKAKLEQLFQDEVAKAQQLREEQ-QRQQQQ 2540
Query: 453 LEEDIALFEAQYLAQAEDTRILRKAVSEAC----TEIDAISVEKRRIMQQWASSLVGMKH 508
+E++ + +A E+ R + E E+ + ++R+ + A ++
Sbjct: 2541 MEQE----RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Query: 509 R----DEAHRAVLEALRGCQHQAKSTDGEIEAYK 538
+ +E HRA L H + T ++ A K
Sbjct: 2597 QLQLLEEQHRAAL------AHSEEVTASQVAATK 2624
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 97.1 bits (240), Expect = 9e-20
Identities = 193/971 (19%), Positives = 378/971 (38%), Gaps = 125/971 (12%)
Query: 245 QDQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIE 304
QD+ Q+ E +A RV++E E A ++ L L+ L ++ + A + ++E
Sbjct: 1472 QDESQRKRQAEVELASRVKAEA--EAAREKQRALQALEE---LRLQAEEAERRLRQAEVE 1526
Query: 305 KLKLDLQELVVATKQSRAQRQELGVNLYE--------VQQHLVHLQKLLEKSHDRHAMAS 356
+ + L A + + A+ Q + E +Q+ V + +L E++ R +
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586
Query: 357 SERRQKEE--------ELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQN-- 406
R +EE +L+A AL + A ++K LA + E + +
Sbjct: 1587 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1646
Query: 407 -IDQDMRD------DIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQLEEDIAL 459
+Q +R ++ Q+ + +R+ AE E + +Q + Q LEE++A
Sbjct: 1647 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1706
Query: 460 FEAQYLAQAEDTRILRKAVSEACTEIDAISVEKRRIMQQWASSLVGMKHRDEAH----RA 515
+ + A + + L +++ E++ + K R ++ S+ K R EA R
Sbjct: 1707 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1766
Query: 516 VLEA---LRGCQHQAKSTD--GEIEAYKKSIMKEEEKNEKLASILN----RTETEATLLQ 566
+ E LR +AK E +A ++ E EKLA+I +TE E L +
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1826
Query: 567 KLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQDQLEQMILTEELQAIRQAIQGELELRR 626
K +++A F RL E+ +Q + + + E L +R+A ELE ++
Sbjct: 1827 KEAENERLRRLAEDEAFQRRRL-----EEQAAQHKAD---IEERLAQLRKASDSELERQK 1878
Query: 627 KTDAAIREKLQEHMTSNKTTKYFNQLILRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS 686
+ + L++ + + K + L +I + A+ TL +
Sbjct: 1879 ---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN-AEDTLRSKEQAE 1934
Query: 687 RLDAHQKTLV--------ELDQDVKKVNELITNSQSEISRRTIL--IERKQGLINFLNKQ 736
A Q+ L E ++ V+K L ++ R+ L +ER + + +
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQK--SLAAEEEAARQRKAALEEVERLKAKVEEARRL 1992
Query: 737 LERMVSELGGEEVGPLELEIKRLSKLIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLA 796
ER E + E KRL H AVQ + +QE+ + Q+++ L
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAH-AFAVQQK------EQELQQTLQQEQSVLD 2045
Query: 797 SL----DASKKELHIMEQKKLRVESKIEQEKKEQKEIEHHMKDLDNDLK---KLNMLMNK 849
L +A+++ E+ +++ E + Q +++ +E E + + + + K
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 850 NRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEEKA-------TLLNQLVE 902
R +E+ E +R +A++ E K + Q +KA TL QL E
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165
Query: 903 AEHQIMLWEKKIQLAK-------EMRSSVDSEIGQTEIRAMKGEIHRMKVRL-----GQL 950
+HQ L ++++Q K RS V+ E+ +R E+ ++K R+ +
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEEL--FSVRVQMEELSKLKARIEAENRALI 2223
Query: 951 LKQQEKMIRAMELAVARRETVTTQA-----EGQRKMDRKALTRTDFHHKQLELRRKIRDV 1005
L+ ++ R ++ + + V +A Q + L D ++ + +++
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 1006 RKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEI 1065
+A E T+ E E LL++Q++L+ QA RL K Q ++
Sbjct: 2284 MQAVQEATRLKAEAE---------LLQQQKELAQEQA---------RRLQEDKEQMAQQL 2325
Query: 1066 VALQTRLKHLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEAL 1125
+ + R + + + L L + + A R R + + E L
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 1126 HKVSQMIANKL 1136
H+ K+
Sbjct: 2386 HRTELATQEKV 2396
Score = 94.4 bits (233), Expect = 6e-19
Identities = 224/1110 (20%), Positives = 445/1110 (40%), Gaps = 112/1110 (10%)
Query: 42 KGEEAVGSTEHPEEVTTQ---AEAAIEEGEVETEGEAAVEGEEEAVSYGDAESEEEYYYT 98
K EA+ EEV Q A+A E+ + E E EA G+ E + E E+
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1664
Query: 99 ETSSPEGQISAADTTYPYFSPPQEL--------PGEEAYDSVSGE-AGLQGFQQEATGPP 149
+ EG T + QEL GE+ + E A LQ AT
Sbjct: 1665 QRQLAEG------TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 150 ESRERRVTSPEPSHGVLGPS----EQMGQVTSGPAVGRLTGST--------EEPQGQVLP 197
+ E + VL S E+ + TS + RL E + + L
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778
Query: 198 MGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ-----DQIQQPS 252
+ + +L+ E V E + G E ++ + + +++++ +
Sbjct: 1779 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1838
Query: 253 TEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQIEKLKLDLQE 312
+E R+E + + +A+ E +L L + Q L RQ +++ ++
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIE-ERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897
Query: 313 LVVATKQSRAQRQELGVNLYEVQQHLVHL-----QKLLEKSHDRHAMASSERRQKEEELQ 367
L + +++ A + EL + L ++ + Q LE + R A ERR++E E +
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957
Query: 368 AARALYTKTCAAANEE--RKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVVKKA 425
++L AA EE R++ AAL+ E+E L + + + + + Q+ ++A
Sbjct: 1958 VQKSL------AAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 426 ETERIRAEIEKKKQDLYVDQLTTRAQQ-LEEDIALFEAQYLAQAEDTRILRKAVSEACTE 484
+R++AE +K V Q QQ L+++ ++ + Q +AE R + EA +
Sbjct: 2011 AQKRLQAE--EKAHAFAVQQKEQELQQTLQQEQSVLD-QLRGEAEAARRAAEEAEEARVQ 2067
Query: 485 IDAISVEKRRIMQQWASSLVGMKHRDEAHRAVLEALRGCQHQAKSTDGEIEAYKKSIMKE 544
+ + + RR +++ A L + +E +A +A + K + E EA +++ ++
Sbjct: 2068 AEREAAQSRRQVEE-AERL--KQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQ 2122
Query: 545 EEKNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTEDALSQ-DQLE 603
+K A+ + E +K Q L ++ ++ + T RL L++T+ + D+
Sbjct: 2123 AALRQKQAA-----DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2177
Query: 604 QMILTEELQAIRQAIQGELEL-----RRKTDAAIREKLQ-EHMTSNKTTKYFNQLILRLQ 657
Q + E +A RQ Q E EL + + + ++ +++ E+ K Q L+ +
Sbjct: 2178 QRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE 2237
Query: 658 KEKTNMMTHLSKINGDIAQTTLDITHTSSRLDAHQKTLVE--LDQDVKKVNELITNSQSE 715
EK + + AQ + + A Q+ L E L + ++ V E T ++E
Sbjct: 2238 AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA-TRLKAE 2296
Query: 716 ISRRTILIERKQGLINFLNKQLERMVSELGGEEVG---PLELEIKRLSKLIDEHDGKAVQ 772
E Q L + E+M +L E G LE E +R ++ E +
Sbjct: 2297 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE----- 2351
Query: 773 AQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQEKKEQKEIEHH 832
RL+ + ++++ Q +K+ + +K R E +++ + +E
Sbjct: 2352 ------RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2405
Query: 833 MKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASERETIKMQDKLNQLSEE 892
+ D+D ++L + + E+L+Q ++ + LK+ E +T++ + QL +E
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQ------LKSEEMQTVQQE----QLLQE 2455
Query: 893 KATLLNQLVEAEHQIMLWEKKIQLAK-EMRSSVDSEIGQT-----EIRAMKGEIHRMKVR 946
L + + ++ E+ I+ K ++ E+ + E + + ++ + + R
Sbjct: 2456 TQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515
Query: 947 LGQLLKQQEKMIRAMELAVARRETVTTQAEGQRKMDRKALTRTDFH-HKQLE-LRRKIRD 1004
L +++ + E V R++ Q E QR+ + L + +QL+ L + R
Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575
Query: 1005 VRKATDECTKTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEAD-----LTRLGALKR 1059
++E T + + +T N L+ + + FD L L G L
Sbjct: 2576 ALAHSEEVTASQVAATKTLPN-GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSA 2634
Query: 1060 QNLSEIVALQTRLKHLQAVKEGRYVFLFRS 1089
+ L + T + L ++ R+ RS
Sbjct: 2635 EELQRLAQGHTTVDELARREDVRHYLQGRS 2664
Score = 87.8 bits (216), Expect = 5e-17
Identities = 192/957 (20%), Positives = 382/957 (39%), Gaps = 162/957 (16%)
Query: 245 QDQIQ-QPSTEEGAMAERVESEGSD-EEAEDEGSQLVVLDPDHPLMVRFQAALKNYLNRQ 302
Q+QIQ P + A+ E++ E + EE E G ++ + ++ A+K+Y Q
Sbjct: 1198 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKV---EECQRFAKQYINAIKDY-ELQ 1253
Query: 303 IEKLKLDLQELVVATKQSRAQRQELGVNLYEVQQHLVHLQKLLEKSHDRHAMASSERRQK 362
+ K L+ + K+ + Q V + E H +L + S R+
Sbjct: 1254 LVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 363 EEELQAARALYTKTCAAANEERKKLAALQTEMENLALHLFYMQNIDQDMRDDIRVMTQVV 422
EEE + A EER++LA ++ +E R Q
Sbjct: 1313 EEEERLAEQQRA-------EERERLAEVEAALEK--------------QRQLAEAHAQA- 1350
Query: 423 KKAETERIRAEIEKKKQDLYV--DQLTTRAQQLEEDIALFEAQYLAQAEDTRILRKAVSE 480
KA+ ER E++++ Q+ V ++ AQQ + I E Q L Q+ + I KA
Sbjct: 1351 -KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKARQA 1408
Query: 481 ACTEIDAISVEKR-RIMQQWASSLVGMKHRDEAHRAVLEALRG----CQHQAKSTDGEIE 535
E + +E+ R+++ L + + L+ALR + Q + E E
Sbjct: 1409 EAAERSRLRIEEEIRVVRL---QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465
Query: 536 AYKKSIMKEEE-KNEKLASILNRTETEATLLQKLTTQCLTKQVALQSQFNTYRLTLQDTE 594
++ + E + K + + +R + EA ++ KQ ALQ+ RL ++ E
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAARE-------KQRALQA-LEELRLQAEEAE 1517
Query: 595 DALSQDQLEQMILTE-ELQAIRQAIQGELELRRKTDAAIREKLQEHMTSNKTTKYFNQLI 653
L Q ++E+ + L+ +++ + EL+ +R + A +L+ + ++
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE----EHVAVAQ 1573
Query: 654 LRLQKEKTNMMTHLSKINGDIAQTTLDITHTSS------RLDAH----QKTLVELDQDVK 703
LR + E+ ++ + A+ L+ + RL A QK+L + + + +
Sbjct: 1574 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633
Query: 704 KVNELITNSQSEISRRTILIERKQGLINFLNKQLE--RMVSELGGEEVGPLELEIKRLSK 761
K ++ E RR E+ ++LE R ++E ++ E E+ RL
Sbjct: 1634 K-----EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1688
Query: 762 LIDEHDGKAVQAQVTWLRLQQEMVKVTQEQEEQLASLDASKKELHIMEQKKLRVESKIEQ 821
++ + + + RLQ+E TQ+++E A L + E+ ++ K R E E+
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EE 1745
Query: 822 EKKEQKEIEHHMKDLDNDLKKLNMLMNKNRCSSEELEQNNRVTENEFVRSLKASER---- 877
+ ++ + ++ ++L + R +EE ++ ++ E + R +ER
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805
Query: 878 --------------------ETIKMQDKLNQLSEEKATLLNQLVE--AEHQIMLWEKKIQ 915
E ++L +L+E++A +L E A+H+ + E+ Q
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865
Query: 916 LAKEMRSSVDSEIG------------QTEIRAMKGEIHR-------MKVRLGQLLKQQEK 956
L K S ++ + G + EI A+K + +++ LG++ E
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925
Query: 957 MIRA---MELAVARRETVTTQAEGQRKMDRKALTRTDFHHKQLELRRKIRDVRKATDECT 1013
+R+ EL AR+ + + E +R+ + + ++ ++ +RK A +E
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVE 1980
Query: 1014 KTVLELEETQRNVSSSLLEKQEKLSVIQADFDTLEADLTRLGALKRQNLSEIVALQTRLK 1073
+ ++EE +R L E+ E+ S Q +A + K
Sbjct: 1981 RLKAKVEEARR-----LRERAEQESARQLQ----------------------LAQEAAQK 2013
Query: 1074 HLQAVKEGRYVFLFRSKQSLVLERQRLDKRLALIATILDRVRDEYPQFQEALHKVSQ 1130
LQA +E + F + K+ Q L + L ++LD++R E + A + +
Sbjct: 2014 RLQA-EEKAHAFAVQQKE------QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Score = 44.7 bits (104), Expect = 5e-04
Identities = 125/574 (21%), Positives = 230/574 (40%), Gaps = 91/574 (15%)
Query: 18 ASEGEKEGNNESHMVSPPEKDDGQKGEEAVGSTEHPEEVTTQAEAAIEEGEVETEGEAAV 77
A+E +E ++ + + ++ E S E + QA+AA E+ E E EAA
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Query: 78 EGEEEAVSY-----GDAESEEEYYYTE-TSSPEGQISAADTTYPYFSPPQELPGEEAYDS 131
+ E + DAE E+ + E T + Q+ TT +L + +
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL-----QLEETDHQKN 2171
Query: 132 VSGEAGLQGFQQEATGPPESR---ERRVTSPEPSHGVLGPSEQMGQVTSGPAVGRLTGST 188
+ E LQ + EAT R E + S L + + + + R +T
Sbjct: 2172 LLDEE-LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2230
Query: 189 E---EPQGQVLPMGVQHRFRLSHGSDIESSDLEEFVSQEPVIPPGVPDAHPREGDLPVFQ 245
+ + + + + + RLS + E++ L + ++ + + +E +
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQ-EAARLRQLAEEDLAQQRALAEKMLKE------K 2283
Query: 246 DQIQQPSTEEGAMAERVESEGSDEEAEDEGSQLVVLDPDHPLMVR--------FQAALKN 297
Q Q +T A AE ++ + E A+++ + L D M + FQ L+
Sbjct: 2284 MQAVQEATRLKAEAELLQQQ--KELAQEQARR---LQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 298 YLNRQI------EKLKLDLQELVVA-------TKQSRAQRQELGVNLYEVQ---QHLVHL 341
RQ+ E+LKL + E+ A ++ R Q +E+G L+ + Q V L
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 342 QKLLE-----KSHD----RHAMASSERRQKEEELQAARALYTKTCAAANEERKKLAALQT 392
+ LE HD R A+A E R+KE+ Q A+ L K +EE + + Q
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELE-REKEKLQQEAKLLQLK-----SEEMQTVQQEQL 2452
Query: 393 EMENLALHLFYMQNIDQDMRDDIRVMTQVVKKAETERIRAEIEKKKQDLYVDQLTTRAQQ 452
E AL ++ D ++ + R + Q +KA+ E++ + K Q L +Q + QQ
Sbjct: 2453 LQETQALQQSFLSEKDSLLQRE-RFIEQ--EKAKLEQLFQDEVAKAQQLREEQ-QRQQQQ 2508
Query: 453 LEEDIALFEAQYLAQAEDTRILRKAVSEAC----TEIDAISVEKRRIMQQWASSLVGMKH 508
+E++ + +A E+ R + E E+ + ++R+ + A ++
Sbjct: 2509 MEQE----RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2564
Query: 509 R----DEAHRAVLEALRGCQHQAKSTDGEIEAYK 538
+ +E HRA L H + T ++ A K
Sbjct: 2565 QLQLLEEQHRAAL------AHSEEVTASQVAATK 2592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,613,377
Number of Sequences: 37866
Number of extensions: 1866055
Number of successful extensions: 20433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 278
Number of HSP's successfully gapped in prelim test: 1224
Number of HSP's that attempted gapping in prelim test: 10698
Number of HSP's gapped (non-prelim): 6044
length of query: 1142
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1029
effective length of database: 13,968,660
effective search space: 14373751140
effective search space used: 14373751140
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.