Search of human proteins with 148664188

Search of human proteins with 148664188

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148664188 leucine rich repeat containing 43 isoform 2 [Homo
sapiens]
         (471 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148664188 leucine rich repeat containing 43 isoform 2 [Homo s...   932   0.0  
gi|148664213 leucine rich repeat containing 43 isoform 1 [Homo s...   932   0.0  
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    44   3e-04
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    44   3e-04
gi|31621309 leucine rich repeat containing 6 [Homo sapiens]            41   0.002
gi|239754500 PREDICTED: Leucine-rich repeat-containing protein E...    40   0.005
gi|239749060 PREDICTED: Leucine-rich repeat-containing protein E...    40   0.005
gi|239743086 PREDICTED: Leucine-rich repeat-containing protein E...    40   0.005
gi|239508737 PREDICTED: Leucine-rich repeat-containing protein E...    40   0.005
gi|66472382 nischarin [Homo sapiens]                                   39   0.013
gi|7657218 bromodomain-containing protein 4 isoform short [Homo ...    37   0.030
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    37   0.030
gi|203098334 Myc-binding protein-associated protein [Homo sapiens]     37   0.030
gi|157674358 leucine rich repeat containing 50 [Homo sapiens]          37   0.030
gi|21361639 DIPB protein [Homo sapiens]                                37   0.039
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    37   0.051
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ...    36   0.066
gi|118421089 chromodomain helicase DNA binding protein 2 isoform...    36   0.066
gi|150378449 X-ray radiation resistance associated 1 [Homo sapiens]    36   0.066
gi|150417978 platelet glycoprotein Ib alpha polypeptide precurso...    36   0.086
gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]            35   0.15 
gi|223718151 leucine rich transmembrane and 0-methyltransferase ...    35   0.15 
gi|21687175 leucine rich transmembrane and 0-methyltransferase d...    35   0.15 
gi|239752518 PREDICTED: similar to leucine rich repeat containin...    35   0.19 
gi|4507677 heat shock protein 90kDa beta, member 1 [Homo sapiens]      35   0.19 
gi|55743114 leucine rich repeat containing 49 [Homo sapiens]           35   0.19 
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     34   0.25 
gi|61742786 leucine rich repeat and death domain containing prot...    34   0.25 
gi|61742784 leucine rich repeat and death domain containing prot...    34   0.25 
gi|61742782 leucine rich repeat and death domain containing prot...    34   0.25 

>gi|148664188 leucine rich repeat containing 43 isoform 2 [Homo
           sapiens]
          Length = 471

 Score =  932 bits (2410), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 1   MECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLR 60
           MECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLR
Sbjct: 1   MECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLR 60

Query: 61  TLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQ 120
           TLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQ
Sbjct: 61  TLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQ 120

Query: 121 EAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVLAEIV 180
           EAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVLAEIV
Sbjct: 121 EAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVLAEIV 180

Query: 181 KPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEESGESELSVISGPSTILQ 240
           KPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEESGESELSVISGPSTILQ
Sbjct: 181 KPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEESGESELSVISGPSTILQ 240

Query: 241 MPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFL 300
           MPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFL
Sbjct: 241 MPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFL 300

Query: 301 LAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVL 360
           LAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVL
Sbjct: 301 LAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVL 360

Query: 361 KKKKEPPKELRQDPPILQVLGRGLVILEPLLAGEPLVSTVCNFGVVRTLTSDRLTLARDS 420
           KKKKEPPKELRQDPPILQVLGRGLVILEPLLAGEPLVSTVCNFGVVRTLTSDRLTLARDS
Sbjct: 361 KKKKEPPKELRQDPPILQVLGRGLVILEPLLAGEPLVSTVCNFGVVRTLTSDRLTLARDS 420

Query: 421 KKIKKVAKKEKPKAVIPIYEGDYHPEPLTVEVQIQLNQCRSAEEALRMFAV 471
           KKIKKVAKKEKPKAVIPIYEGDYHPEPLTVEVQIQLNQCRSAEEALRMFAV
Sbjct: 421 KKIKKVAKKEKPKAVIPIYEGDYHPEPLTVEVQIQLNQCRSAEEALRMFAV 471


>gi|148664213 leucine rich repeat containing 43 isoform 1 [Homo
           sapiens]
          Length = 656

 Score =  932 bits (2410), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 1   MECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLR 60
           MECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLR
Sbjct: 186 MECLCAHPPAGLQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLR 245

Query: 61  TLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQ 120
           TLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQ
Sbjct: 246 TLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQ 305

Query: 121 EAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVLAEIV 180
           EAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVLAEIV
Sbjct: 306 EAQFVVTIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVLAEIV 365

Query: 181 KPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEESGESELSVISGPSTILQ 240
           KPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEESGESELSVISGPSTILQ
Sbjct: 366 KPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEESGESELSVISGPSTILQ 425

Query: 241 MPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFL 300
           MPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFL
Sbjct: 426 MPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFL 485

Query: 301 LAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVL 360
           LAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVL
Sbjct: 486 LAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVL 545

Query: 361 KKKKEPPKELRQDPPILQVLGRGLVILEPLLAGEPLVSTVCNFGVVRTLTSDRLTLARDS 420
           KKKKEPPKELRQDPPILQVLGRGLVILEPLLAGEPLVSTVCNFGVVRTLTSDRLTLARDS
Sbjct: 546 KKKKEPPKELRQDPPILQVLGRGLVILEPLLAGEPLVSTVCNFGVVRTLTSDRLTLARDS 605

Query: 421 KKIKKVAKKEKPKAVIPIYEGDYHPEPLTVEVQIQLNQCRSAEEALRMFAV 471
           KKIKKVAKKEKPKAVIPIYEGDYHPEPLTVEVQIQLNQCRSAEEALRMFAV
Sbjct: 606 KKIKKVAKKEKPKAVIPIYEGDYHPEPLTVEVQIQLNQCRSAEEALRMFAV 656


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 60/219 (27%), Positives = 92/219 (42%), Gaps = 49/219 (22%)

Query: 165 EEGEMNES-AGVLAEIVKPSPSLELLVEESPEEVV--EDVIEDIVEEVTEEVEGSL-ESE 220
           EEGE  E      AE  +     E  VEE  EEV   E+++ D   E  E+ +  + +S 
Sbjct: 562 EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSP 621

Query: 221 VEESGESELSVISGPSTILQMPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVI 280
           VEE G+S +            P++  EE  K          P P + +      P    +
Sbjct: 622 VEEKGKSPV------------PKSPVEEKGK---------SPVPKSPVEEKGKSP----V 656

Query: 281 PCSYEMQHSLRDLVPLKAFLLAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKG 340
           P S           P++    +  + + VEEK  S     P   SP+   K K E  K G
Sbjct: 657 PKS-----------PVEEKGKSPVSKSPVEEKAKS-----PVPKSPVEEAKSKAEVGK-G 699

Query: 341 KEKDRTGKGEKEPAKEWKVLKKKKEP---PKELRQDPPI 376
           ++K+   K  KE  KE KV KK+++P   P++ + + P+
Sbjct: 700 EQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPV 738


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 60/219 (27%), Positives = 92/219 (42%), Gaps = 49/219 (22%)

Query: 165 EEGEMNES-AGVLAEIVKPSPSLELLVEESPEEVV--EDVIEDIVEEVTEEVEGSL-ESE 220
           EEGE  E      AE  +     E  VEE  EEV   E+++ D   E  E+ +  + +S 
Sbjct: 186 EEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSP 245

Query: 221 VEESGESELSVISGPSTILQMPRASAEELAKLRLRIDPRLCPSPGTVLFSTAHKPWAEVI 280
           VEE G+S +            P++  EE  K          P P + +      P    +
Sbjct: 246 VEEKGKSPV------------PKSPVEEKGK---------SPVPKSPVEEKGKSP----V 280

Query: 281 PCSYEMQHSLRDLVPLKAFLLAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDKKG 340
           P S           P++    +  + + VEEK  S     P   SP+   K K E  K G
Sbjct: 281 PKS-----------PVEEKGKSPVSKSPVEEKAKS-----PVPKSPVEEAKSKAEVGK-G 323

Query: 341 KEKDRTGKGEKEPAKEWKVLKKKKEP---PKELRQDPPI 376
           ++K+   K  KE  KE KV KK+++P   P++ + + P+
Sbjct: 324 EQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPV 362


>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
          Length = 466

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/67 (37%), Positives = 37/67 (55%), Gaps = 1/67 (1%)

Query: 39  LVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDI 98
           L  LDL  N + +L S + +L+   HL+ L L GNP A   +YR   + +L QL  LD  
Sbjct: 90  LAKLDLTVNFIGELSS-IKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGK 148

Query: 99  TVSPNEK 105
            + P+E+
Sbjct: 149 EIEPSER 155


>gi|239754500 PREDICTED: Leucine-rich repeat-containing protein
           ENSP00000371558 [Homo sapiens]
          Length = 336

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 17/111 (15%)

Query: 12  LQHLGLGHNKLLGP--------LESLYVTAN---------HWPNLVSLDLGFNDLTDLQS 54
           L++L L HNKL G         L  LY+  N         + P+L  L L  N+LT++ +
Sbjct: 118 LKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDA 177

Query: 55  MVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEK 105
            V  L+ + +L++L L  NPL     YR   I  L  + +LD   V+  E+
Sbjct: 178 TVKELKGMLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKER 228


>gi|239749060 PREDICTED: Leucine-rich repeat-containing protein
           ENSP00000371558 [Homo sapiens]
          Length = 336

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 17/111 (15%)

Query: 12  LQHLGLGHNKLLGP--------LESLYVTAN---------HWPNLVSLDLGFNDLTDLQS 54
           L++L L HNKL G         L  LY+  N         + P+L  L L  N+LT++ +
Sbjct: 118 LKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDA 177

Query: 55  MVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEK 105
            V  L+ + +L++L L  NPL     YR   I  L  + +LD   V+  E+
Sbjct: 178 TVKELKGMLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKER 228


>gi|239743086 PREDICTED: Leucine-rich repeat-containing protein
           ENSP00000371558 [Homo sapiens]
          Length = 336

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 17/111 (15%)

Query: 12  LQHLGLGHNKLLGP--------LESLYVTAN---------HWPNLVSLDLGFNDLTDLQS 54
           L++L L HNKL G         L  LY+  N         + P+L  L L  N+LT++ +
Sbjct: 118 LKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDA 177

Query: 55  MVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEK 105
            V  L+ + +L++L L  NPL     YR   I  L  + +LD   V+  E+
Sbjct: 178 TVKELKGMLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKER 228


>gi|239508737 PREDICTED: Leucine-rich repeat-containing protein
           ENSP00000371558 [Homo sapiens]
          Length = 336

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 17/111 (15%)

Query: 12  LQHLGLGHNKLLGP--------LESLYVTAN---------HWPNLVSLDLGFNDLTDLQS 54
           L++L L HNKL G         L  LY+  N         + P+L  L L  N+LT++ +
Sbjct: 118 LKYLWLHHNKLHGITFLTRNYCLTELYLNNNAIFEIEGLHYLPSLHILLLHHNELTNIDA 177

Query: 55  MVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEK 105
            V  L+ + +L++L L  NPL     YR   I  L  + +LD   V+  E+
Sbjct: 178 TVKELKGMLNLKILSLYQNPLCQYNLYRLYIIYHLPGVELLDRNQVTEKER 228


>gi|66472382 nischarin [Homo sapiens]
          Length = 1504

 Score = 38.5 bits (88), Expect = 0.013
 Identities = 62/264 (23%), Positives = 107/264 (40%), Gaps = 41/264 (15%)

Query: 12  LQHLGLGHNKL---------LGPLESLYVTANHWPNL---------VSLDLGFNDLTDLQ 53
           L HL L +NKL         LG +++L +  N   +L         V+LDL  N +  ++
Sbjct: 334 LVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQME 393

Query: 54  SM--VTSLRTLRHLRLLVLQGNPLALVPYYRGLTI----DSLAQLCVLDDITVSPNEKHL 107
            +  + SL  L H+ LL    NPL+++P YR   +    +  +++C+ D +T    EK L
Sbjct: 394 EVRSIGSLPCLEHVSLL---NNPLSIIPDYRTKVLAQFGERASEVCLDDTVT---TEKEL 447

Query: 108 FRGLSLNGDLLAQEAQFVVTIGNIRGVLDTSVLDP---EPRPEGPFITYNYYVTYDFVKD 164
                L     A+E +  ++    +G  D+ +       P    P +          +  
Sbjct: 448 DTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQPILS 507

Query: 165 EEGEMNESAGVLAEIVKPSPSLELLVEESP-EEVVEDVIEDI-----VEEVTEEVEGSLE 218
            +G M      LA  +  + S  L  E  P  +   D +E I       +   +V G++ 
Sbjct: 508 NQGIMFVQEEALASSLSSTDS--LTPEHQPIAQGCSDSLESIPAGQAASDDLRDVPGAVG 565

Query: 219 SEVEESGESELSVISGPSTILQMP 242
               E  E E+ V+ G   I+ +P
Sbjct: 566 GASPEHAEPEVQVVPGSGQIIFLP 589



 Score = 33.5 bits (75), Expect = 0.43
 Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 5/56 (8%)

Query: 12  LQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRL 67
           ++ L L HN LL     +     H  NLV LDL +N L+ L+ + T L  ++ L L
Sbjct: 312 IEFLDLSHNGLL-----VVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNL 362


>gi|7657218 bromodomain-containing protein 4 isoform short [Homo
           sapiens]
          Length = 722

 Score = 37.4 bits (85), Expect = 0.030
 Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 2/65 (3%)

Query: 309 VEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPK 368
           ++E++ +    L A+  P   K  K EKDKK K+K++  +  KE  +E K  K K+ PPK
Sbjct: 514 LQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKR--KEEVEENKKSKAKEPPPK 571

Query: 369 ELRQD 373
           + +++
Sbjct: 572 KTKKN 576


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
           sapiens]
          Length = 1362

 Score = 37.4 bits (85), Expect = 0.030
 Identities = 22/65 (33%), Positives = 38/65 (58%), Gaps = 2/65 (3%)

Query: 309 VEEKILSWPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPK 368
           ++E++ +    L A+  P   K  K EKDKK K+K++  +  KE  +E K  K K+ PPK
Sbjct: 514 LQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKR--KEEVEENKKSKAKEPPPK 571

Query: 369 ELRQD 373
           + +++
Sbjct: 572 KTKKN 576


>gi|203098334 Myc-binding protein-associated protein [Homo sapiens]
          Length = 984

 Score = 37.4 bits (85), Expect = 0.030
 Identities = 67/287 (23%), Positives = 116/287 (40%), Gaps = 41/287 (14%)

Query: 176 LAEIVKPSPSLELLVEESPEEVV--------EDVIEDIVEEVTEEVEGSLESEVEESG-- 225
           ++E   P P  E L E   ++          + ++E+I+ E + +V+ S +S  E  G  
Sbjct: 695 ISETQVPRPENEALRESGSQKARVGTKSPQRKSIMEEILVEESPDVD-STKSPWEPDGLP 753

Query: 226 --ESELSVISGPSTILQMPRASAEELAKLRL-RIDPRLCPSPGTVLFSTAHKP----WAE 278
             E  L +      ++ +P  +  E A +RL +    LC  P  +  +  H+     W +
Sbjct: 754 LLEWNLCLEDFRKAVMVLPDENHREDALMRLNKAALELCQKPRPLQSNLLHQMCLQLWRD 813

Query: 279 VIPCSYEMQHSLRDLVPLKAFLLAGTTVTIVEEKILSWPVVLPAVDSPLSAKKGKGEKDK 338
           VI         LR ++ L         + + EE+    P ++  V  P+  K GK E+  
Sbjct: 814 VIDSLVGHSMWLRSVLGLPE--KETIYLNVPEEQDQKSPPIME-VKVPVG-KAGKEERKG 869

Query: 339 KGKEKDRTGKGEKEPAKEWKVLKKKKEPP-------------KELRQD-----PPILQVL 380
             +EK + G  +KE  K  K+L K+  P              K   QD      P   ++
Sbjct: 870 AAQEKKQLGIKDKEDKKGAKLLGKEDRPNSKKHKAKDDKKVIKSASQDRFSLEDPTPDII 929

Query: 381 GRGLVILEPLLAGEPLVSTVCNF-GVVRTLTSDRLTLARDSKKIKKV 426
                 ++PL+ G+   S      G++ TL +D + LA +   IK V
Sbjct: 930 LSSQEPIDPLVMGKYTQSLHSEVRGLLDTLVTDLMVLADELSPIKNV 976


>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
          Length = 725

 Score = 37.4 bits (85), Expect = 0.030
 Identities = 25/68 (36%), Positives = 37/68 (54%), Gaps = 2/68 (2%)

Query: 39  LVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQGNP-LALVPYYRGLTIDSLAQLCVLDD 97
           L  LDL  N L+D + +++ L ++  LR+L L GNP +  +P YR      L  L  LDD
Sbjct: 222 LCVLDLSHNKLSDPE-ILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDD 280

Query: 98  ITVSPNEK 105
             V P ++
Sbjct: 281 RPVFPKDR 288


>gi|21361639 DIPB protein [Homo sapiens]
          Length = 344

 Score = 37.0 bits (84), Expect = 0.039
 Identities = 25/67 (37%), Positives = 36/67 (53%), Gaps = 2/67 (2%)

Query: 164 DEEGEMNESAGVLAEIVKPSPSLEL--LVEESPEEVVEDVIEDIVEEVTEEVEGSLESEV 221
           ++E E+   AG  +E  + S S E     EES +E  E+  ED  EE+ +E E   E + 
Sbjct: 86  EQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDN 145

Query: 222 EESGESE 228
           +E GESE
Sbjct: 146 QEEGESE 152


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 36.6 bits (83), Expect = 0.051
 Identities = 20/45 (44%), Positives = 28/45 (62%), Gaps = 2/45 (4%)

Query: 330 KKGKGEKDKKGKEKDRTGKGEKEPA--KEWKVLKKKKEPPKELRQ 372
           ++ KGEKDK   E +R G+GEKE A  +EWK    +++  KE  Q
Sbjct: 673 EREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQ 717


>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
           isoform 2 [Homo sapiens]
          Length = 1153

 Score = 36.2 bits (82), Expect = 0.066
 Identities = 24/55 (43%), Positives = 27/55 (49%), Gaps = 4/55 (7%)

Query: 321 PAVDSPLSAKKGKGEKDK----KGKEKDRTGKGEKEPAKEWKVLKKKKEPPKELR 371
           P  D P+  KK K  K K    K KE+D+  K EKE  K  K  KKK    KE R
Sbjct: 830 PEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKKSPKPKKKKHRKEKEER 884


>gi|118421089 chromodomain helicase DNA binding protein 2 isoform 1
            [Homo sapiens]
          Length = 1828

 Score = 36.2 bits (82), Expect = 0.066
 Identities = 20/44 (45%), Positives = 28/44 (63%), Gaps = 1/44 (2%)

Query: 325  SPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPK 368
            SP+  KK K +++K+ KEK  + + +KE  KE K  K KKE PK
Sbjct: 1386 SPMK-KKQKKKENKENKEKQMSSRKDKEGDKERKKSKDKKEKPK 1428


>gi|150378449 X-ray radiation resistance associated 1 [Homo sapiens]
          Length = 792

 Score = 36.2 bits (82), Expect = 0.066
 Identities = 26/73 (35%), Positives = 36/73 (49%), Gaps = 6/73 (8%)

Query: 7   HPPAGLQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLR 66
           H    L+ L L  N +    +++YV    +  L  LDL FN LT     +  L  L HLR
Sbjct: 137 HTFPALKELDLAFNGI----KTIYVKYGDFKLLEFLDLSFNSLT--VEAICDLGILPHLR 190

Query: 67  LLVLQGNPLALVP 79
           +L+L GN L  +P
Sbjct: 191 VLLLTGNGLTSLP 203


>gi|150417978 platelet glycoprotein Ib alpha polypeptide precursor
           [Homo sapiens]
          Length = 639

 Score = 35.8 bits (81), Expect = 0.086
 Identities = 26/65 (40%), Positives = 35/65 (53%), Gaps = 6/65 (9%)

Query: 15  LGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQGNP 74
           L L HN+L    +SL +     P L  LD+ FN LT L   + +LR L  L+ L L+GN 
Sbjct: 98  LDLSHNQL----QSLPLLGQTLPALTVLDVSFNRLTSLP--LGALRGLGELQELYLKGNE 151

Query: 75  LALVP 79
           L  +P
Sbjct: 152 LKTLP 156


>gi|239752449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 170

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 15/105 (14%)

Query: 270 STAHKPWAEVIPCS--YEMQHSLRDLVPLKAFLLAGTTVTIVEEKILSWPVVLPAVDSPL 327
           ST   P A V+P S  + ++  +  L+ + AF  AG ++             LP    P 
Sbjct: 55  STHSDPSATVLPGSSTHRLKGKIFHLISI-AFCDAGPSLH------------LPLHGLPQ 101

Query: 328 SAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPKELRQ 372
             +K + EK+KK K+K +  K +K+  K+ K  KKKK+  K  R+
Sbjct: 102 REEKKEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRK 146



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 17/43 (39%), Positives = 25/43 (58%)

Query: 330 KKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPKELRQ 372
           K+ + EK KK K+K +  K +K+  K+ K  KKKK   K  R+
Sbjct: 106 KEKEKEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRK 148



 Score = 29.6 bits (65), Expect = 6.2
 Identities = 16/43 (37%), Positives = 26/43 (60%)

Query: 330 KKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPKELRQ 372
           KK K +K KK K+K +  K +K+  K+ K  +K+K   K+ R+
Sbjct: 114 KKKKKKKKKKKKKKKKKKKKKKKKKKKRKRKRKRKRKRKKKRK 156


>gi|223718151 leucine rich transmembrane and 0-methyltransferase
           domain containing isoform 2 [Homo sapiens]
          Length = 158

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 16/81 (19%)

Query: 19  HNKLLGPLESLYVTAN----HWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQG-- 72
           +N +L  L      A+    H  NL  +DL FNDLT +  ++T   T  +L +L L G  
Sbjct: 57  NNNVLNDLRDFNQVASQLLEHPENLAWIDLSFNDLTSIDPVLT---TFFNLSVLYLHGNS 113

Query: 73  -------NPLALVPYYRGLTI 86
                  N LA++P  R LT+
Sbjct: 114 IQRLGEVNKLAVLPRLRSLTL 134


>gi|21687175 leucine rich transmembrane and 0-methyltransferase
           domain containing isoform 1 [Homo sapiens]
          Length = 192

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 16/81 (19%)

Query: 19  HNKLLGPLESLYVTAN----HWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQG-- 72
           +N +L  L      A+    H  NL  +DL FNDLT +  ++T   T  +L +L L G  
Sbjct: 57  NNNVLNDLRDFNQVASQLLEHPENLAWIDLSFNDLTSIDPVLT---TFFNLSVLYLHGNS 113

Query: 73  -------NPLALVPYYRGLTI 86
                  N LA++P  R LT+
Sbjct: 114 IQRLGEVNKLAVLPRLRSLTL 134


>gi|239752518 PREDICTED: similar to leucine rich repeat containing
           50, partial [Homo sapiens]
          Length = 489

 Score = 34.7 bits (78), Expect = 0.19
 Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 6/96 (6%)

Query: 12  LQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQ 71
           L  L L HN++     +     ++ P L  L L FN+++   S V+ L     L  +   
Sbjct: 49  LTELNLRHNQI-----TFVRDVDNLPCLQHLFLSFNNISSFDS-VSCLADSSSLSDITFD 102

Query: 72  GNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHL 107
           GNP+A   +Y+   + ++ QL  LD   ++  E+ +
Sbjct: 103 GNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 138


>gi|4507677 heat shock protein 90kDa beta, member 1 [Homo sapiens]
          Length = 803

 Score = 34.7 bits (78), Expect = 0.19
 Identities = 17/48 (35%), Positives = 25/48 (52%)

Query: 180 VKPSPSLELLVEESPEEVVEDVIEDIVEEVTEEVEGSLESEVEESGES 227
           + P   +E   EE PEE  ED  ED  ++  EE++   + E E + ES
Sbjct: 749 IDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKES 796


>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
          Length = 686

 Score = 34.7 bits (78), Expect = 0.19
 Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 6/96 (6%)

Query: 12  LQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQ 71
           L  L L HN++     +     ++ P L  L L FN+++   S V+ L     L  +   
Sbjct: 224 LTELNLRHNQI-----TFVRDVDNLPCLQHLFLSFNNISSFDS-VSCLADSSSLSDITFD 277

Query: 72  GNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHL 107
           GNP+A   +Y+   + ++ QL  LD   ++  E+ +
Sbjct: 278 GNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 313


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 34.3 bits (77), Expect = 0.25
 Identities = 62/239 (25%), Positives = 89/239 (37%), Gaps = 38/239 (15%)

Query: 142 PEPRPEGPFITYNYYVTYDFVKDEEGEMNESAGVLAEIVKPSPSLELLVEESPEE--VVE 199
           PE  P+ P ++     T+  VK EE           ++V+ S    ++VEE  EE  V E
Sbjct: 423 PEGLPKIPSVS-----THIKVKSEEK---------IKVVEKSEKETVIVEEQTEETQVTE 468

Query: 200 DVIEDIVEEVTEEV----EGSLESEVEESGESELSVISGPSTILQMPRASAEELAKLRLR 255
           +V E+  +E  EE     EG  E E  E GE E    S P+     P   A+   K   +
Sbjct: 469 EVTEEEEKEAKEEEGKEEEGGEEEEA-EGGEEETK--SPPAEEAASPEKEAKSPVKEEAK 525

Query: 256 IDPRLCPSPGTVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFLLAGTTVTIVEEKILS 315
                  SP     + A  P  E      E++   +   P K    +       E++   
Sbjct: 526 -------SP-----AEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAK 573

Query: 316 WPVVLPAVDSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPKELRQDP 374
            P     V SP  AK    E+ K   E     K +    +E K   + K P KE  + P
Sbjct: 574 SPA---EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629


>gi|61742786 leucine rich repeat and death domain containing protein
           isoform 3 [Homo sapiens]
          Length = 893

 Score = 34.3 bits (77), Expect = 0.25
 Identities = 29/68 (42%), Positives = 35/68 (51%), Gaps = 7/68 (10%)

Query: 12  LQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQ 71
           LQ L L  N L    ++L        +L+ L+L  N L   QS+  SL  LR LRLLVL 
Sbjct: 196 LQRLDLSQNLL----DTLPPEIGGLGSLLELNLASNRL---QSLPASLAGLRSLRLLVLH 248

Query: 72  GNPLALVP 79
            N LA VP
Sbjct: 249 SNLLASVP 256


>gi|61742784 leucine rich repeat and death domain containing protein
           isoform 1 [Homo sapiens]
          Length = 910

 Score = 34.3 bits (77), Expect = 0.25
 Identities = 29/68 (42%), Positives = 35/68 (51%), Gaps = 7/68 (10%)

Query: 12  LQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQ 71
           LQ L L  N L    ++L        +L+ L+L  N L   QS+  SL  LR LRLLVL 
Sbjct: 196 LQRLDLSQNLL----DTLPPEIGGLGSLLELNLASNRL---QSLPASLAGLRSLRLLVLH 248

Query: 72  GNPLALVP 79
            N LA VP
Sbjct: 249 SNLLASVP 256


>gi|61742782 leucine rich repeat and death domain containing protein
           isoform 2 [Homo sapiens]
          Length = 753

 Score = 34.3 bits (77), Expect = 0.25
 Identities = 29/68 (42%), Positives = 35/68 (51%), Gaps = 7/68 (10%)

Query: 12  LQHLGLGHNKLLGPLESLYVTANHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQ 71
           LQ L L  N L    ++L        +L+ L+L  N L   QS+  SL  LR LRLLVL 
Sbjct: 50  LQRLDLSQNLL----DTLPPEIGGLGSLLELNLASNRL---QSLPASLAGLRSLRLLVLH 102

Query: 72  GNPLALVP 79
            N LA VP
Sbjct: 103 SNLLASVP 110


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.135    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,401,579
Number of Sequences: 37866
Number of extensions: 931899
Number of successful extensions: 4578
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 4090
Number of HSP's gapped (non-prelim): 554
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.