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Search of human proteins with 148612816
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens]
(991 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens] 2021 0.0
gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens] 822 0.0
gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens] 822 0.0
gi|4557365 Bloom syndrome protein [Homo sapiens] 286 9e-77
gi|14591902 RecQ protein-like [Homo sapiens] 276 7e-74
gi|14591904 RecQ protein-like [Homo sapiens] 276 7e-74
gi|110735439 Werner syndrome protein [Homo sapiens] 214 2e-55
gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent... 214 2e-55
gi|116812616 RecQ protein-like 4 [Homo sapiens] 183 8e-46
gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo sap... 64 5e-10
gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens] 61 6e-09
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 57 7e-08
gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo sap... 56 1e-07
gi|13129006 nucleolar protein GU2 [Homo sapiens] 56 1e-07
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 56 1e-07
gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo sapi... 56 2e-07
gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo sapi... 56 2e-07
gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens] 55 4e-07
gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens] 55 4e-07
gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked ... 54 6e-07
gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked [... 54 6e-07
gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens] 54 9e-07
gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens] 54 9e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 53 1e-06
gi|55749865 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 [Homo sapi... 53 1e-06
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 52 4e-06
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ... 50 1e-05
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [... 50 1e-05
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ... 50 1e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 49 2e-05
>gi|148612816 RecQ protein-like 5 isoform 1 [Homo sapiens]
Length = 991
Score = 2021 bits (5236), Expect = 0.0
Identities = 991/991 (100%), Positives = 991/991 (100%)
Query: 1 MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL 60
MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL
Sbjct: 1 MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL 60
Query: 61 CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK 120
CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK
Sbjct: 61 CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK 120
Query: 121 PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR 180
PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR
Sbjct: 121 PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR 180
Query: 181 SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG 240
SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG
Sbjct: 181 SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG 240
Query: 241 NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL 300
NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL
Sbjct: 241 NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL 300
Query: 301 VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR 360
VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR
Sbjct: 301 VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR 360
Query: 361 LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYF 420
LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYF
Sbjct: 361 LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYF 420
Query: 421 GDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPSQGNGFDPELYEGGRKGYGD 480
GDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPSQGNGFDPELYEGGRKGYGD
Sbjct: 421 GDALPACAKGCDHCQNPTAVRRRLEALERSSSWSKTCIGPSQGNGFDPELYEGGRKGYGD 480
Query: 481 FSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMQLRKGKDPKIEEFVPPDENCPLKEASSR 540
FSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMQLRKGKDPKIEEFVPPDENCPLKEASSR
Sbjct: 481 FSRYDEGSGGSGDEGRDEAHKREWNLFYQKQMQLRKGKDPKIEEFVPPDENCPLKEASSR 540
Query: 541 RIPRLTVKAREHCLRLLEEALSSNRQSTRTADEADLRAKAVELEHETFRNAKVANLYKAS 600
RIPRLTVKAREHCLRLLEEALSSNRQSTRTADEADLRAKAVELEHETFRNAKVANLYKAS
Sbjct: 541 RIPRLTVKAREHCLRLLEEALSSNRQSTRTADEADLRAKAVELEHETFRNAKVANLYKAS 600
Query: 601 VLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFP 660
VLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFP
Sbjct: 601 VLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFP 660
Query: 661 KGSCPFQTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGS 720
KGSCPFQTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGS
Sbjct: 661 KGSCPFQTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGS 720
Query: 721 AHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLAS 780
AHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLAS
Sbjct: 721 AHYGGPSPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLAS 780
Query: 781 APEAEGACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTP 840
APEAEGACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTP
Sbjct: 781 APEAEGACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTP 840
Query: 841 EVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQ 900
EVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQ
Sbjct: 841 EVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQ 900
Query: 901 DPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVK 960
DPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVK
Sbjct: 901 DPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVK 960
Query: 961 EEAQNLIRHFFHGRARCESEADWHGLCGPQR 991
EEAQNLIRHFFHGRARCESEADWHGLCGPQR
Sbjct: 961 EEAQNLIRHFFHGRARCESEADWHGLCGPQR 991
>gi|51242943 RecQ protein-like 5 isoform 3 [Homo sapiens]
Length = 410
Score = 822 bits (2124), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL 60
MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL
Sbjct: 1 MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL 60
Query: 61 CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK 120
CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK
Sbjct: 61 CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK 120
Query: 121 PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR 180
PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR
Sbjct: 121 PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR 180
Query: 181 SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG 240
SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG
Sbjct: 181 SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG 240
Query: 241 NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL 300
NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL
Sbjct: 241 NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL 300
Query: 301 VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR 360
VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR
Sbjct: 301 VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR 360
Query: 361 LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG 410
LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG
Sbjct: 361 LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG 410
>gi|51242947 RecQ protein-like 5 isoform 2 [Homo sapiens]
Length = 435
Score = 822 bits (2124), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL 60
MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL
Sbjct: 1 MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL 60
Query: 61 CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK 120
CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK
Sbjct: 61 CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREK 120
Query: 121 PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR 180
PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR
Sbjct: 121 PQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALR 180
Query: 181 SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG 240
SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG
Sbjct: 181 SRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYG 240
Query: 241 NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL 300
NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL
Sbjct: 241 NLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTL 300
Query: 301 VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR 360
VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR
Sbjct: 301 VQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCR 360
Query: 361 LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG 410
LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG
Sbjct: 361 LYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG 410
>gi|4557365 Bloom syndrome protein [Homo sapiens]
Length = 1417
Score = 286 bits (731), Expect = 9e-77
Identities = 173/435 (39%), Positives = 246/435 (56%), Gaps = 27/435 (6%)
Query: 10 FDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLA 69
F + + K FG +F+T E+ A++ +D F+ MPTG GKSLCYQLPA ++
Sbjct: 649 FPHTKEMMKIFHKKFGLHNFRTNQLEAINAALL--GEDCFILMPTGGGKSLCYQLPACVS 706
Query: 70 KGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYIT 129
G+T+V+SPL +LI DQV L +L + + L + E + L ++ P K+LY+T
Sbjct: 707 PGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVT 766
Query: 130 PE-MAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPC 188
PE + AS+ TL +L R LL+ V+DEAHCVSQWGHDFR DY R+ LR + P
Sbjct: 767 PEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPV 826
Query: 189 VALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLK 248
+ALTATA P+VQ+D+ L + +P +F R NL Y V K+ + CL+
Sbjct: 827 MALTATANPRVQKDILTQLKILRP-QVFSMSFNRHNLKYYVLPKKPKKVAFD-----CLE 880
Query: 249 ALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWM-E 307
+ + GI+YC +R C+ +A L G+ A AYHAGL S R VQ W+ +
Sbjct: 881 WIRKHHP---YDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQ 937
Query: 308 EKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRND 367
+ VI ATI+FGMG+DK +VRFV H ++ KS+ GYYQESGRAGRDG+ S C L+Y+ +D
Sbjct: 938 DGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHD 997
Query: 368 RDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEEL-GCRHAAIAKYFGD---A 423
++ LI + EK GN + + ++V +CE + CR + YFG+
Sbjct: 998 VTRLKRLI------MMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFN 1051
Query: 424 LPACAK----GCDHC 434
C K CD+C
Sbjct: 1052 PDFCKKHPDVSCDNC 1066
>gi|14591902 RecQ protein-like [Homo sapiens]
Length = 649
Score = 276 bits (706), Expect = 7e-74
Identities = 161/433 (37%), Positives = 242/433 (55%), Gaps = 27/433 (6%)
Query: 15 RVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITI 74
+V+ L+ VF + F+ PLQ T+ V K+VF+ MPTG GKSLCYQLPAL + G T+
Sbjct: 78 KVKDILQNVFKLEKFR-PLQLE-TINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTL 135
Query: 75 VVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYITPE-MA 133
V+ PLI+L++DQ+ L L + + LN+ S + K + A++ + + K++Y+TPE +A
Sbjct: 136 VICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIA 195
Query: 134 ASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTA 193
S F L + + VDE HC SQWGHDFRPDY LG L+ + +A + LTA
Sbjct: 196 KSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTA 255
Query: 194 TATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQE 253
TAT V D L ++K F R NL+Y+V+ K N +DF +
Sbjct: 256 TATNHVLTDAQKILCIEKCFT-FTASFNRPNLYYEVRQKP------SNTEDFIEDIVKLI 308
Query: 254 ADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVI 313
+ GI+YC +++ EQ+ + L G++A AYHA L+ ++T V W ++ V+
Sbjct: 309 NGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVV 368
Query: 314 VATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSF 373
VAT++FGMG+DK +VRFV H +++KSM YYQESGRAGRD + C LYY D ++S
Sbjct: 369 VATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISS 428
Query: 374 LIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG-CRHAAIAKYFGDA--LPACAKG 430
++ E Q+ +V++C+ + CR +A++F + AC K
Sbjct: 429 MVVMENVGQQK--------------LYEMVSYCQNISKCRRVLMAQHFDEVWNSEACNKM 474
Query: 431 CDHCQNPTAVRRR 443
CD+C +A R+
Sbjct: 475 CDNCCKDSAFERK 487
>gi|14591904 RecQ protein-like [Homo sapiens]
Length = 649
Score = 276 bits (706), Expect = 7e-74
Identities = 161/433 (37%), Positives = 242/433 (55%), Gaps = 27/433 (6%)
Query: 15 RVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITI 74
+V+ L+ VF + F+ PLQ T+ V K+VF+ MPTG GKSLCYQLPAL + G T+
Sbjct: 78 KVKDILQNVFKLEKFR-PLQLE-TINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTL 135
Query: 75 VVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYITPE-MA 133
V+ PLI+L++DQ+ L L + + LN+ S + K + A++ + + K++Y+TPE +A
Sbjct: 136 VICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIA 195
Query: 134 ASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTA 193
S F L + + VDE HC SQWGHDFRPDY LG L+ + +A + LTA
Sbjct: 196 KSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTA 255
Query: 194 TATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQE 253
TAT V D L ++K F R NL+Y+V+ K N +DF +
Sbjct: 256 TATNHVLTDAQKILCIEKCFT-FTASFNRPNLYYEVRQKP------SNTEDFIEDIVKLI 308
Query: 254 ADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVI 313
+ GI+YC +++ EQ+ + L G++A AYHA L+ ++T V W ++ V+
Sbjct: 309 NGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVV 368
Query: 314 VATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSF 373
VAT++FGMG+DK +VRFV H +++KSM YYQESGRAGRD + C LYY D ++S
Sbjct: 369 VATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISS 428
Query: 374 LIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELG-CRHAAIAKYFGDA--LPACAKG 430
++ E Q+ +V++C+ + CR +A++F + AC K
Sbjct: 429 MVVMENVGQQK--------------LYEMVSYCQNISKCRRVLMAQHFDEVWNSEACNKM 474
Query: 431 CDHCQNPTAVRRR 443
CD+C +A R+
Sbjct: 475 CDNCCKDSAFERK 487
>gi|110735439 Werner syndrome protein [Homo sapiens]
Length = 1432
Score = 214 bits (546), Expect = 2e-55
Identities = 144/437 (32%), Positives = 237/437 (54%), Gaps = 39/437 (8%)
Query: 12 PERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKG 71
P + LK FG SFK P+Q +V++ +D M TG GKSLC+Q P +
Sbjct: 532 PNEEQVTCLKMYFGHSSFK-PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGK 590
Query: 72 ITIVVSPLIALIQDQVDHLLTLKVRVSSLNSK-LSAQERKELLADLEREKPQTKILYITP 130
I +V+SPLI+L++DQV L++++S++ + L + + + +L D++ K +I+Y+TP
Sbjct: 591 IGLVISPLISLMEDQV-----LQLKMSNIPACFLGSAQSENVLTDIKLGK--YRIVYVTP 643
Query: 131 EMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVA 190
E + + L L + ++ + VDEAHC+S+WGHDFR + +LG+L++ L P VA
Sbjct: 644 EYCSGN--MGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVA 701
Query: 191 LTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKAL 250
LTATA+ ++ED+ L+L+ P I T R NL+ +V+ K + +L+ F +K
Sbjct: 702 LTATASSSIREDIVRCLNLRNP-QITCTGFDRPNLYLEVRRKT--GNILQDLQPFLVKTS 758
Query: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
+G + I+YC +R+ +Q+ EL ++ YHAG+ S R + + ++ +++
Sbjct: 759 SHWEFEGPT---IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEI 815
Query: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQ 370
++ATI+FGMG++KA++R V H+ K M YYQE GRAGRDG S C + ++ D +
Sbjct: 816 QCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINL 875
Query: 371 VSFL---IRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYFGD----- 422
L IR E +L K +MA + + CR I +F D
Sbjct: 876 NRHLLTEIRNEKFRLY---------KLKMMA--KMEKYLHSSRCRRQIILSHFEDKQVQK 924
Query: 423 ---ALPACAKGCDHCQN 436
+ K CD+C++
Sbjct: 925 ASLGIMGTEKCCDNCRS 941
>gi|169218196 PREDICTED: similar to Werner syndrome ATP-dependent
helicase, partial [Homo sapiens]
Length = 1140
Score = 214 bits (546), Expect = 2e-55
Identities = 144/437 (32%), Positives = 237/437 (54%), Gaps = 39/437 (8%)
Query: 12 PERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKG 71
P + LK FG SFK P+Q +V++ +D M TG GKSLC+Q P +
Sbjct: 240 PNEEQVTCLKMYFGHSSFK-PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGK 298
Query: 72 ITIVVSPLIALIQDQVDHLLTLKVRVSSLNSK-LSAQERKELLADLEREKPQTKILYITP 130
I +V+SPLI+L++DQV L++++S++ + L + + + +L D++ K +I+Y+TP
Sbjct: 299 IGLVISPLISLMEDQV-----LQLKMSNIPACFLGSAQSENVLTDIKLGK--YRIVYVTP 351
Query: 131 EMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVA 190
E + + L L + ++ + VDEAHC+S+WGHDFR + +LG+L++ L P VA
Sbjct: 352 EYCSGN--MGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVA 409
Query: 191 LTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKAL 250
LTATA+ ++ED+ L+L+ P I T R NL+ +V+ K + +L+ F +K
Sbjct: 410 LTATASSSIREDIVRCLNLRNP-QITCTGFDRPNLYLEVRRKT--GNILQDLQPFLVKTS 466
Query: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
+G + I+YC +R+ +Q+ EL ++ YHAG+ S R + + ++ +++
Sbjct: 467 SHWEFEGPT---IIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEI 523
Query: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQ 370
++ATI+FGMG++KA++R V H+ K M YYQE GRAGRDG S C + ++ D +
Sbjct: 524 QCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINL 583
Query: 371 VSFL---IRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKYFGD----- 422
L IR E +L K +MA + + CR I +F D
Sbjct: 584 NRHLLTEIRNEKFRLY---------KLKMMA--KMEKYLHSSRCRRQIILSHFEDKQVQK 632
Query: 423 ---ALPACAKGCDHCQN 436
+ K CD+C++
Sbjct: 633 ASLGIMGTEKCCDNCRS 649
>gi|116812616 RecQ protein-like 4 [Homo sapiens]
Length = 1208
Score = 183 bits (464), Expect = 8e-46
Identities = 137/421 (32%), Positives = 208/421 (49%), Gaps = 53/421 (12%)
Query: 8 FPFDPERRVRSTLKKVF------GFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLC 61
+ P ++ T +VF G +F+ P QE A M ++ G + V +PTGAGKSLC
Sbjct: 454 YSLGPSGQLAETPAEVFQALEQLGHQAFR-PGQERAVMRILSGISTLLV-LPTGAGKSLC 511
Query: 62 YQLPALL----AKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLE 117
YQLPALL + +T+VVSPL++L+ DQV L ++ + ++S ++ ++R+ +L +
Sbjct: 512 YQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPC-LKAACIHSGMTRKQRESVLQKIR 570
Query: 118 REKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRL- 176
Q +L +TPE + P L +++ +DEAHC+SQW H+FRP YLR+
Sbjct: 571 AA--QVHVLMLTPEALVGAGGLPPAAQLPP---VAFACIDEAHCLSQWSHNFRPCYLRVC 625
Query: 177 GALRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELIS 236
LR R+G + LTATAT + DV L + + + NL V
Sbjct: 626 KVLRERMGVHCFLGLTATATRRTASDVAQHLAVAEEPDLHGPAPVPTNLHLSVSMDR--- 682
Query: 237 DPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELS--------------CR 282
+ L L + + L I+YC RE E++A L
Sbjct: 683 ----DTDQALLTLLQGKRFQNLDSI-IIYCNRREDTERIAALLRTCLHAAWVPGSGGRAP 737
Query: 283 GVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAG 342
A+AYHAG+ + ER VQ +M+ ++ V+VAT++FGMG+D+ +VR V H + S
Sbjct: 738 KTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFES 797
Query: 343 YYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDAL 402
Y Q GRAGRDG+P+ C L+ D L+E R + +D +A L
Sbjct: 798 YVQAVGRAGRDGQPAHCHLFLQPQGED------------LRELRRHVHADSTDFLAVKRL 845
Query: 403 V 403
V
Sbjct: 846 V 846
>gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo
sapiens]
Length = 796
Score = 64.3 bits (155), Expect = 5e-10
Identities = 91/420 (21%), Positives = 174/420 (41%), Gaps = 40/420 (9%)
Query: 2 SSHHTTFPFDPERRVRSTLKKV--FGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKS 59
S + F R LK + GF TP+Q++ + G KD+ C TG GK+
Sbjct: 212 SQYDENLSFQDMNLSRPLLKAITAMGFKQ-PTPIQKACIPVGLLG-KDICACAATGTGKT 269
Query: 60 LCYQLPAL---LAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLS--AQERKELLA 114
+ LP L + K V+ ++ L+ + L ++V S+ +L+ L
Sbjct: 270 AAFALPVLERLIYKPRQAPVTRVLVLVPTR-----ELGIQVHSVTRQLAQFCNITTCLAV 324
Query: 115 DLEREKPQTKILYITPEM--AASSSFQPTLNSLVSRHLLSY--LVVDEA-HCVSQWGHDF 169
K Q L P++ A L++ S HL S L++DEA + ++ +
Sbjct: 325 GGLDVKSQEAALRAAPDILIATPGRLIDHLHNCPSFHLSSIEVLILDEADRMLDEYFEEQ 384
Query: 170 RPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDV 229
+ +R+ + H + +AT T +V++ A++ LK PV IF F
Sbjct: 385 MKEIIRMCS-----HHRQTMLFSATMTDEVKD--LASVSLKNPVRIFVNSNTDVAPFLRQ 437
Query: 230 QFKELISDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAY 289
+F + + G+ + L + + +++ +T++ ++ I L G+
Sbjct: 438 EFIRIRPNREGDREAIVAALLTRTFTDHV----MLFTQTKKQAHRMHILLGLMGLQVGEL 493
Query: 290 HAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGR 349
H L ++R + +E++ ++VAT G+D V+ V ++ + ++ Y GR
Sbjct: 494 HGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTIKHYVHRVGR 553
Query: 350 AGRDGKPSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEEL 409
R G+ ++R + KE+ K KA KA I+ D ++ F +++
Sbjct: 554 TARAGRAGRSVSLVGEDERKML-----KEIVK-----AAKAPVKARILPQDVILKFRDKI 603
>gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]
Length = 614
Score = 60.8 bits (146), Expect = 6e-09
Identities = 88/344 (25%), Positives = 135/344 (39%), Gaps = 48/344 (13%)
Query: 54 TGAGKSLCYQLPAL--------LAKG---ITIVVSPLIALIQDQVDHLLTLKVRVSSLNS 102
TG+GK+L Y LPA+ L +G I +V++P L Q QV + R L S
Sbjct: 140 TGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQ-QVQQVAAEYCRACRLKS 198
Query: 103 KL--SAQERKELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAH 160
+ + DLER +I TP F + + R +YLV+DEA
Sbjct: 199 TCIYGGAPKGPQIRDLERG---VEICIATPGRLID--FLECGKTNLRR--TTYLVLDEAD 251
Query: 161 CVSQWGHDFRPDYLRL-GALRSRLGHAPCVALTATATPQVQEDVF--------AALHLKK 211
+ G F P ++ +R A Q+ ED AL L
Sbjct: 252 RMLDMG--FEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSA 309
Query: 212 PVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREA 271
I + ++ +DV+ KD L L +E IV+ T+
Sbjct: 310 NHNILQI----VDVCHDVE------------KDEKLIRLMEEIMSEKENKTIVFVETKRR 353
Query: 272 CEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFV 331
C++L ++ G A H ER V N++ K P+++AT G+D +V+FV
Sbjct: 354 CDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFV 413
Query: 332 AHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLI 375
+++ S Y GR R K +++ N+ QVS LI
Sbjct: 414 INYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLI 457
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 57.4 bits (137), Expect = 7e-08
Identities = 84/381 (22%), Positives = 168/381 (44%), Gaps = 45/381 (11%)
Query: 15 RVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL------- 67
++ ++LKK G++ TP+Q A A++ G +D+ TG+GK++ + LP
Sbjct: 382 KILNSLKK-HGYEK-PTPIQTQAIPAIMSG-RDLIGIAKTGSGKTIAFLLPMFRHIMDQR 438
Query: 68 -LAKG---ITIVVSPL----IALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLERE 119
L +G I ++++P + + ++ TL +RV + E+ +A+L+R
Sbjct: 439 SLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQ---IAELKRG 495
Query: 120 KPQTKILYITP----EMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLR 175
+I+ TP +M A++S + T + ++Y+V+DEA + G F P +R
Sbjct: 496 ---AEIIVCTPGRMIDMLAANSGRVT-----NLRRVTYVVLDEADRMFDMG--FEPQVMR 545
Query: 176 LGALRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELI 235
+ + + V +AT P+ E A L KP+ + R+ + DV+ + ++
Sbjct: 546 I--VDNVRPDRQTVMFSATF-PRAME-ALARRILSKPIEVQVGG--RSVVCSDVEQQVIV 599
Query: 236 SDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKA 295
+ L+ LG + SG I++ +E + L +L + H G+
Sbjct: 600 IEEEKKFLKL-LELLGHYQE---SGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQ 655
Query: 296 SERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGK 355
+R + ND+ ++VAT G+D ++ V +++ Y +GR GR G
Sbjct: 656 YDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGN 715
Query: 356 PSWCRLYYSRNDRDQVSFLIR 376
+ + + + +I+
Sbjct: 716 KGYAYTFITEDQARYAGDIIK 736
>gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo
sapiens]
Length = 648
Score = 56.2 bits (134), Expect = 1e-07
Identities = 84/403 (20%), Positives = 165/403 (40%), Gaps = 54/403 (13%)
Query: 16 VRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIV 75
V +KK GF TP+Q A V++G D+ TG GK+LCY +P I +V
Sbjct: 253 VMENIKKA-GFQK-PTPIQSQAWPIVLQGI-DLIGVAQTGTGKTLCYLMPGF----IHLV 305
Query: 76 VSPLIALIQDQVDHLLTLKVRVSSLN-----SKLSAQERKELLA--------DLEREKPQ 122
+ P + +++ L+ R +L K S + + + +E K
Sbjct: 306 LQPSLKGQRNRPGMLVLTPTRELALQVEGECCKYSYKGLRSVCVYGGGNRDEQIEELKKG 365
Query: 123 TKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSR 182
I+ TP +++ V+ ++YLV+DEA + G F P +++ L
Sbjct: 366 VDIIIATPGRLNDLQ----MSNFVNLKNITYLVLDEADKMLDMG--FEPQIMKI--LLDV 417
Query: 183 LGHAPCVALTATATPQVQEDVFAALHLKKPVAIF-------KTPCFRANLFYDVQFKELI 235
V +AT V A +LK+P+ ++ + N+ +
Sbjct: 418 RPDRQTVMTSATWPHSVHR--LAQSYLKEPMIVYVGTLDLVAVSSVKQNIIVTTE----- 470
Query: 236 SDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKA 295
+ + +++ F L+++ DK IV+ + + L+ +L ++ ++ H +
Sbjct: 471 EEKWSHMQTF-LQSMSS-TDKV-----IVFVSRKAVADHLSSDLILGNISVESLHGDREQ 523
Query: 296 SERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGK 355
+R ++ KV +++AT G+D +V V +++ +++ Y GR GR G+
Sbjct: 524 RDREKALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAGR 583
Query: 356 PSWCRLYYSRNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMA 398
+RND + + E+ + E+ ++ MA
Sbjct: 584 TGVSITTLTRND-----WRVASELINILERANQSIPEELVSMA 621
>gi|13129006 nucleolar protein GU2 [Homo sapiens]
Length = 737
Score = 56.2 bits (134), Expect = 1e-07
Identities = 32/121 (26%), Positives = 57/121 (47%), Gaps = 1/121 (0%)
Query: 257 GLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVAT 316
G G I++C T++ ++A+ + NA+ H + S+R + + E V+VAT
Sbjct: 387 GSEGRAIIFCETKKNVTEMAMNPHIKQ-NAQCLHGDIAQSQREITLKGFREGSFKVLVAT 445
Query: 317 ISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIR 376
G+D V V + + + Y SGR GR G+ C +Y +R Q+ ++ +
Sbjct: 446 NVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICICFYQPRERGQLRYVEQ 505
Query: 377 K 377
K
Sbjct: 506 K 506
>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
Length = 820
Score = 56.2 bits (134), Expect = 1e-07
Identities = 85/383 (22%), Positives = 152/383 (39%), Gaps = 71/383 (18%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQ--DQVD 88
TP+Q A + + N+D+ TG+GK+ + +P L + I P I I+ DQ
Sbjct: 415 TPIQRQA-IPIGLQNRDIIGVAETGSGKTAAFLIPLL----VWITTLPKIDRIEESDQGP 469
Query: 89 HLLTLKVRVSSLNSKLSAQERK----------ELLADLEREKPQTKILYITPEMAASSSF 138
+ + L L ++ + K ++ + RE ++ + A+
Sbjct: 470 YAIIL-APTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPG- 527
Query: 139 QPTLNSLVSRHLL----SYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPC------ 188
++ L +R+L+ +Y+V+DEA + G F PD ++ L H P
Sbjct: 528 -RLIDVLENRYLVLSRCTYVVLDEADRMIDMG--FEPDVQKI------LEHMPVSNQKPD 578
Query: 189 ------------------------VALTATATPQVQEDVFAALHLKKPVAIFKTPCFRAN 224
V TAT P V+ A +L++P ++ + +
Sbjct: 579 TDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVER--LARSYLRRPAVVYIGSAGKPH 636
Query: 225 LFYDVQFKELISDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGV 284
+ Q L+S+ K L L Q D + I++ ++ C+ LA L G
Sbjct: 637 ERVE-QKVFLMSESEKRKK--LLAILEQGFDPPI----IIFVNQKKGCDVLAKSLEKMGY 689
Query: 285 NAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYY 344
NA H G +R ++ ++VAT G G+D +V V ++++AK++ Y
Sbjct: 690 NACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYI 749
Query: 345 QESGRAGRDGKPSWCRLYYSRND 367
GR GR GK + ++ D
Sbjct: 750 HRIGRTGRAGKSGVAITFLTKED 772
>gi|38569503 ATP-dependent RNA helicase ROK1 isoform b [Homo
sapiens]
Length = 491
Score = 55.8 bits (133), Expect = 2e-07
Identities = 81/370 (21%), Positives = 148/370 (40%), Gaps = 27/370 (7%)
Query: 11 DPERRVRSTLKKVFGFDSFK--TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALL 68
D E ++ S L + F+ TP+Q A ++ G +++ PTG+GK+L + +P L+
Sbjct: 59 DQEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHG-RELLASAPTGSGKTLAFSIPILM 117
Query: 69 A------KGI-TIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKP 121
KG +++SP L L+ + ++ + + A K
Sbjct: 118 QLKQPANKGFRALIISPTRELASQIHRELIKIS---EGTGFRIHMIHKAAVAAKKFGPKS 174
Query: 122 QTK--ILYITPEMAASSSFQ-PTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGA 178
K IL TP Q P L S + +LVVDE+ + + G D L
Sbjct: 175 SKKFDILVTTPNRLIYLLKQDPPGIDLAS---VEWLVVDESDKLFEDGKTGFRDQLASIF 231
Query: 179 LRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDP 238
L +AT V++ + L+L +++ N + +EL+
Sbjct: 232 LACTSHKVRRAMFSATFAYDVEQ--WCKLNLDNVISV---SIGARNSAVETVEQELL--- 283
Query: 239 YGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASER 298
+ + L A+ + KG + +V+ ++ E ++L EL G+N HA +R
Sbjct: 284 FVGSETGKLLAMRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQR 343
Query: 299 TLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSW 358
+ + K+ V++ T G+D V V +++ S Y GR GR G
Sbjct: 344 DNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGK 403
Query: 359 CRLYYSRNDR 368
+++ +D+
Sbjct: 404 AITFFTEDDK 413
>gi|38569505 ATP-dependent RNA helicase ROK1 isoform a [Homo
sapiens]
Length = 599
Score = 55.8 bits (133), Expect = 2e-07
Identities = 81/370 (21%), Positives = 148/370 (40%), Gaps = 27/370 (7%)
Query: 11 DPERRVRSTLKKVFGFDSFK--TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALL 68
D E ++ S L + F+ TP+Q A ++ G +++ PTG+GK+L + +P L+
Sbjct: 167 DQEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHG-RELLASAPTGSGKTLAFSIPILM 225
Query: 69 A------KGI-TIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKP 121
KG +++SP L L+ + ++ + + A K
Sbjct: 226 QLKQPANKGFRALIISPTRELASQIHRELIKIS---EGTGFRIHMIHKAAVAAKKFGPKS 282
Query: 122 QTK--ILYITPEMAASSSFQ-PTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGA 178
K IL TP Q P L S + +LVVDE+ + + G D L
Sbjct: 283 SKKFDILVTTPNRLIYLLKQDPPGIDLAS---VEWLVVDESDKLFEDGKTGFRDQLASIF 339
Query: 179 LRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDP 238
L +AT V++ + L+L +++ N + +EL+
Sbjct: 340 LACTSHKVRRAMFSATFAYDVEQ--WCKLNLDNVISV---SIGARNSAVETVEQELL--- 391
Query: 239 YGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASER 298
+ + L A+ + KG + +V+ ++ E ++L EL G+N HA +R
Sbjct: 392 FVGSETGKLLAMRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQR 451
Query: 299 TLVQNDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSW 358
+ + K+ V++ T G+D V V +++ S Y GR GR G
Sbjct: 452 DNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGK 511
Query: 359 CRLYYSRNDR 368
+++ +D+
Sbjct: 512 AITFFTEDDK 521
>gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]
Length = 731
Score = 54.7 bits (130), Expect = 4e-07
Identities = 85/360 (23%), Positives = 140/360 (38%), Gaps = 33/360 (9%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL--------LAKG---ITIVVSPL 79
TP+Q + G +D+ TG+GK+L Y LPA+ L +G I +V++P
Sbjct: 195 TPIQCQGFPLALSG-RDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPT 253
Query: 80 IALIQDQVDHLLTLKVRVSSLNSKL--SAQERKELLADLEREKPQTKILYITPEMAASSS 137
L Q QV + + S L S + + DLER +I TP
Sbjct: 254 RELAQ-QVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERG---VEICIATPGRLID-- 307
Query: 138 FQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRL-GALRSRLGHAPCVALTATAT 196
F + + + R +YLV+DEA + G F P ++ +R A
Sbjct: 308 FLESGKTNLRR--CTYLVLDEADRMLDMG--FEPQIRKIVDQIRPDRQTLMWSATWPKEV 363
Query: 197 PQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADK 256
Q+ ED F + + V L + +++ + KD L L +E
Sbjct: 364 RQLAED-FLRDYTQINVG-------NLELSANHNILQIVDVCMESEKDHKLIQLMEEIMA 415
Query: 257 GLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVAT 316
I++ T+ C+ L + G A H ER V N++ K P+++AT
Sbjct: 416 EKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIAT 475
Query: 317 ISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIR 376
G+D +V+FV +++ S Y GR R +++ + Q LI+
Sbjct: 476 DVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIK 535
>gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]
Length = 729
Score = 54.7 bits (130), Expect = 4e-07
Identities = 85/360 (23%), Positives = 140/360 (38%), Gaps = 33/360 (9%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL--------LAKG---ITIVVSPL 79
TP+Q + G +D+ TG+GK+L Y LPA+ L +G I +V++P
Sbjct: 195 TPIQCQGFPLALSG-RDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPT 253
Query: 80 IALIQDQVDHLLTLKVRVSSLNSKL--SAQERKELLADLEREKPQTKILYITPEMAASSS 137
L Q QV + + S L S + + DLER +I TP
Sbjct: 254 RELAQ-QVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERG---VEICIATPGRLID-- 307
Query: 138 FQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRL-GALRSRLGHAPCVALTATAT 196
F + + + R +YLV+DEA + G F P ++ +R A
Sbjct: 308 FLESGKTNLRR--CTYLVLDEADRMLDMG--FEPQIRKIVDQIRPDRQTLMWSATWPKEV 363
Query: 197 PQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADK 256
Q+ ED F + + V L + +++ + KD L L +E
Sbjct: 364 RQLAED-FLRDYTQINVG-------NLELSANHNILQIVDVCMESEKDHKLIQLMEEIMA 415
Query: 257 GLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVAT 316
I++ T+ C+ L + G A H ER V N++ K P+++AT
Sbjct: 416 EKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPERDWVLNEFRSGKAPILIAT 475
Query: 317 ISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIR 376
G+D +V+FV +++ S Y GR R +++ + Q LI+
Sbjct: 476 DVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTPGNLKQARELIK 535
>gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
[Homo sapiens]
Length = 660
Score = 54.3 bits (129), Expect = 6e-07
Identities = 81/382 (21%), Positives = 148/382 (38%), Gaps = 47/382 (12%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQ---- 86
TP+Q+ A + ++KG +D+ C TG+GK+ + LP +L++ T + +++
Sbjct: 202 TPVQKHA-IPIIKGKRDLMACAQTGSGKTAAFLLP-ILSQIYTDGPGEALKAVKENGRYG 259
Query: 87 ------VDHLLT----LKVRVSSLNSKLSAQERK------------ELLADLEREKPQTK 124
+ +L L V++ K S + R + + DLER
Sbjct: 260 RRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERG---CH 316
Query: 125 ILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSR-- 182
+L TP + + YLV+DEA + G F P R+ +
Sbjct: 317 LLVATPGRLVDMMER----GKIGLDFCKYLVLDEADRMLDMG--FEPQIRRIVEQDTMPP 370
Query: 183 LGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNL 242
G + +AT ++Q L +A+ + N+ V + E +
Sbjct: 371 KGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEDLDK----- 425
Query: 243 KDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQ 302
+ F L LG L+ +V+ T++ + L L G + H +R
Sbjct: 426 RSFLLDILGATGSDSLT---LVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEAL 482
Query: 303 NDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLY 362
+ + K P++VAT G+D +NVR V ++++ + Y GR GR G +
Sbjct: 483 HQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSF 542
Query: 363 YSRNDRDQVSFLIRKEVAKLQE 384
++ + + L+ V QE
Sbjct: 543 FNEKNMNITKDLLDLLVEAKQE 564
>gi|13514809 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
[Homo sapiens]
Length = 660
Score = 54.3 bits (129), Expect = 6e-07
Identities = 81/382 (21%), Positives = 148/382 (38%), Gaps = 47/382 (12%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQ---- 86
TP+Q+ A + ++KG +D+ C TG+GK+ + LP +L++ T + +++
Sbjct: 202 TPVQKHA-IPIIKGKRDLMACAQTGSGKTAAFLLP-ILSQIYTDGPGEALKAVKENGRYG 259
Query: 87 ------VDHLLT----LKVRVSSLNSKLSAQERK------------ELLADLEREKPQTK 124
+ +L L V++ K S + R + + DLER
Sbjct: 260 RRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERG---CH 316
Query: 125 ILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSR-- 182
+L TP + + YLV+DEA + G F P R+ +
Sbjct: 317 LLVATPGRLVDMMER----GKIGLDFCKYLVLDEADRMLDMG--FEPQIRRIVEQDTMPP 370
Query: 183 LGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNL 242
G + +AT ++Q L +A+ + N+ V + E +
Sbjct: 371 KGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEDLDK----- 425
Query: 243 KDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQ 302
+ F L LG L+ +V+ T++ + L L G + H +R
Sbjct: 426 RSFLLDILGATGSDSLT---LVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEAL 482
Query: 303 NDWMEEKVPVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLY 362
+ + K P++VAT G+D +NVR V ++++ + Y GR GR G +
Sbjct: 483 HQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSF 542
Query: 363 YSRNDRDQVSFLIRKEVAKLQE 384
++ + + L+ V QE
Sbjct: 543 FNEKNMNITKDLLDLLVEAKQE 564
>gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]
Length = 938
Score = 53.5 bits (127), Expect = 9e-07
Identities = 31/118 (26%), Positives = 58/118 (49%)
Query: 259 SGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATIS 318
SG +++ + E+LA L G N H + SER V +D+ ++ +PV+VAT
Sbjct: 498 SGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDV 557
Query: 319 FGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIR 376
G+D +++ V ++++A+ + + GR GR G+ + D + L+R
Sbjct: 558 AARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVR 615
>gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]
Length = 938
Score = 53.5 bits (127), Expect = 9e-07
Identities = 31/118 (26%), Positives = 58/118 (49%)
Query: 259 SGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATIS 318
SG +++ + E+LA L G N H + SER V +D+ ++ +PV+VAT
Sbjct: 498 SGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDV 557
Query: 319 FGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFLIR 376
G+D +++ V ++++A+ + + GR GR G+ + D + L+R
Sbjct: 558 AARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVR 615
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 53.1 bits (126), Expect = 1e-06
Identities = 78/317 (24%), Positives = 124/317 (39%), Gaps = 51/317 (16%)
Query: 671 ELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGP---- 726
E E T++ E+ + E E E+G E G E GG P
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKE----------EEGKEEEGGEEEEAEGGEEETKSPPAEE 508
Query: 727 --SPEKKAKS--SSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAP 782
SPEK+AKS S A+ ++ +K++ + A K + + +SPA +
Sbjct: 509 AASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPE--------KAKSPAKEEAKS 560
Query: 783 EAEGACPSCEGVQGPP--MAPEKYTG---EEDGAGGHSPAPPQTEECLRERPSTCPPRDQ 837
E P E + P +PEK EE + + +P + + ++E +
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620
Query: 838 GTPEVQPTPA--KDTWKGKRPRSQQ-------ENPESQPQKRPRPSAKPSVVAEVKGSVS 888
E +PA K K K P ++ ++PE + K P AK V AE K
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE-KAKSPVKAEAKSPEK 679
Query: 889 ASEQGTLNPTAQDPFQLSAPGVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHL 948
A + + A+ P + +P +KE A K +P +E K S E K + +
Sbjct: 680 A--KSPVKAEAKSPEKAKSP---VKEEAKSPEKAKSPVKEEAK--SPEKAKSPVKEEAKT 732
Query: 949 LTQKTSPGRSVKEEAQN 965
+ SP VKEEA++
Sbjct: 733 PEKAKSP---VKEEAKS 746
Score = 50.1 bits (118), Expect = 1e-05
Identities = 105/474 (22%), Positives = 171/474 (36%), Gaps = 54/474 (11%)
Query: 516 KGKDPKIEEFV-PPDENCPLKEASSRRIPRLTVKAREHCLRLLEEALSSNRQSTRTADEA 574
K K P EE PP+ P KE + ++ E+A S ++ ++ EA
Sbjct: 549 KAKSPAKEEAKSPPEAKSPEKEEAKSPAE----------VKSPEKAKSPAKEEAKSPAEA 598
Query: 575 DLRAKAVELEHETFRNAKVANLYKASVLKKVADIHRASKDGQPYDMGGSAKSCSAQAEPP 634
KA E ++ A K A++ K P AKS +A+ P
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE--EAKS-PEKAKSP 655
Query: 635 EPNEYDIPPASHVYSLKPKRVGAGFP-KGSCPFQTATELMETTR--IREQAPQPERGG-- 689
E E P + P + A P K P + + E + ++E+A PE+
Sbjct: 656 EKEEAKSPEKAK----SPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSP 711
Query: 690 ---EHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGPSPEKKAKSSSGGSSLAKGRA 746
E + P + + E+ P + SPEK AK+ S AK A
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEK-AKTLDVKSPEAKTPA 770
Query: 747 SKKQQLLATAAHKDSQSIARFFCRRVESPALL-------ASAPEAEGACPSCEGVQGPPM 799
++ + A + ++S + V+SP A APE E P E V+ P
Sbjct: 771 KEEARSPADKFPEKAKSPVK---EEVKSPEKAKSPLKEDAKAPEKE--IPKKEEVKSPVK 825
Query: 800 APEK----------YTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTPEVQPTPAKD 849
EK EE+ A PA P+TEE + P ++ P+V+
Sbjct: 826 EEEKPQEVKVKEPPKKAEEEKA----PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPA 881
Query: 850 TWKGKRPRSQQENPESQPQKR-PRPSAKPSVVAEVKGSVSASEQGTLNPTAQDPFQLSAP 908
K K + + + E++ +K+ P P + EVK E+ + D + P
Sbjct: 882 VEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP 941
Query: 909 GVSLKEAANVVVKCLTPFYKEGKFASKELFKGFARHLSHLLTQKTSPGRSVKEE 962
++ K T K K K + A+ L+++ S ++ K E
Sbjct: 942 SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995
>gi|55749865 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 [Homo
sapiens]
Length = 631
Score = 53.1 bits (126), Expect = 1e-06
Identities = 81/384 (21%), Positives = 153/384 (39%), Gaps = 44/384 (11%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQVDHL 90
TP+Q A +++G D+ V TG GK+L Y +P G + S I+ Q +
Sbjct: 246 TPIQSQAWPIILQGI-DLIVVAQTGTGKTLSYLMP-----GFIHLDSQPISREQRNGPGM 299
Query: 91 LTLK------VRVSSLNSKLSAQERKELL--------ADLEREKPQTKILYITPEMAASS 136
L L + V + SK S + K + +E I+ TP
Sbjct: 300 LVLTPTRELALHVEAECSKYSYKGLKSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDL 359
Query: 137 SFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATAT 196
+N+ V+ ++YLV+DEA +F P ++ L V +AT
Sbjct: 360 Q----MNNSVNLRSITYLVIDEAD--KMLDMEFEPQIRKI--LLDVRPDRQTVMTSATWP 411
Query: 197 PQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADK 256
V++ A +LK P+ ++ NL K+ I K +AL QE +
Sbjct: 412 DTVRQ--LALSYLKDPMIVY---VGNLNLVAVNTVKQNIIVTTEKEK----RALTQEFVE 462
Query: 257 GLSGCG--IVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIV 314
+S I++ + + L+ + + +G++A++ H + S++ D+ + +++
Sbjct: 463 NMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDFKSGNIKILI 522
Query: 315 ATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRDQVSFL 374
T G+D +V V +++ +++ Y G GR GK ++ D
Sbjct: 523 TTDIVSRGLDLNDVTHVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLITQRDSKMAG-- 580
Query: 375 IRKEVAKLQEKRGNKASDKATIMA 398
E+ K+ ++ + +MA
Sbjct: 581 ---ELIKILDRANQSVPEDLVVMA 601
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 51.6 bits (122), Expect = 4e-06
Identities = 68/319 (21%), Positives = 113/319 (35%), Gaps = 34/319 (10%)
Query: 607 DIHRASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFPKGSCPF 666
D A + QP A +A+P E + + P A + ++P+ GA P+
Sbjct: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAE--WEVQPESEGAEAPEAEKEA 1915
Query: 667 QTATELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGP 726
Q TE +E E GE EP S G ++ E G+
Sbjct: 1916 QPETESVEAL---------ETEGEDEPESE--GAEAQEAEEAAQEAEGQT---------- 1954
Query: 727 SPEKKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAPEAEG 786
PE + S A+ + + L ++++ A+ VE+P EAE
Sbjct: 1955 QPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEE 2014
Query: 787 -ACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTPEVQPT 845
A P +GV+ P + + E +G + Q E E P + EVQ
Sbjct: 2015 EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA 2074
Query: 846 PAKDTWKGKRPRSQQENPESQPQKR--PRPSAKPSV-------VAEVKGSVSASEQGTLN 896
+ + + +Q+ E+QP+ P A+ E +G +G
Sbjct: 2075 EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEA 2134
Query: 897 PTAQDPFQLSAPGVSLKEA 915
P A+ Q + GV ++A
Sbjct: 2135 PEAEGEAQPESEGVEAQDA 2153
Score = 37.7 bits (86), Expect = 0.054
Identities = 54/212 (25%), Positives = 83/212 (39%), Gaps = 13/212 (6%)
Query: 611 ASKDGQPYDMGGSAKSCSAQAEPPEPNEYDIPPASHVYSLKPKRVGAGFPKGSCPFQTAT 670
A + QP G A +A+P E + P A +P+ G P+ Q +
Sbjct: 2185 AEGEAQPESEGIEAPEAEGEAQP-ELEGVEAPEAEE--EAQPEPEGVETPEAEGEAQPES 2241
Query: 671 ELMETTRIREQAPQPERG-GEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGPSPE 729
E ET ++ +PQ G G+ E S + ED P P P G+ P G +
Sbjct: 2242 E-GETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTP--HQRPGSQTGP 2298
Query: 730 KKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAPEAEGACP 789
+++SS G+ K S+ +L D++S R + S+ + P
Sbjct: 2299 SSSRASSWGNCWQKD--SENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAP 2356
Query: 790 SCEGVQGPPM-APEKYTGEEDGAGGHSPAPPQ 820
G + P A E Y +ED A G S AP +
Sbjct: 2357 L--GSRTPEQGASEGYDLQEDQALG-SLAPTE 2385
Score = 33.5 bits (75), Expect = 1.0
Identities = 38/147 (25%), Positives = 49/147 (33%), Gaps = 15/147 (10%)
Query: 774 SPALLASAPEAEGAC----PSCEGVQGPPMAPEKYTGEEDGA----GGHSPAPPQTEECL 825
SP +L +GA C G A E G A G + P PP+ C
Sbjct: 804 SPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCP 863
Query: 826 RERPSTCPPRDQGTPEVQPTPAKDTWKGKRPRSQQENPESQPQKRPRPSA-KPSVVAEVK 884
+ R S+C P G P+ P P P A + S ++
Sbjct: 864 QRRSSSCGSTGSSHQSTARGP------GGSPQEGTRQPGPTPSPGPNSGASRRSSASQGA 917
Query: 885 GSVSASEQGTLNPTAQDPFQLSAPGVS 911
GS SE+ TL Q A GVS
Sbjct: 918 GSRGLSEEKTLRSGGGPQGQEEASGVS 944
>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
[Homo sapiens]
Length = 724
Score = 50.1 bits (118), Expect = 1e-05
Identities = 79/344 (22%), Positives = 135/344 (39%), Gaps = 40/344 (11%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL---LAKGIT------------IV 75
TP+Q+ + ++ G +D+ C TG+GK+ + LP L + GIT I+
Sbjct: 312 TPVQKYSIPIILAG-RDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECII 370
Query: 76 VSPLIALIQDQVDHLLTLKVRVSSLNSKLSA---QERKELLADLEREKPQTKILYITPEM 132
V+P L+ + L+ R S + + A +L + + IL TP
Sbjct: 371 VAPTRELVNQ-----IYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGR 425
Query: 133 AASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALT 192
+ + + YLV+DEA + G F P+ +L + L
Sbjct: 426 LMDIIGKEK----IGLKQIKYLVLDEADRMLDMG--FGPEMKKLISCPGMPSKEQRQTLM 479
Query: 193 ATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFC--LKAL 250
+AT + AA LK +F DVQ L + + L+ +
Sbjct: 480 FSATFPEEIQRLAAEFLKSNY-LFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNI 538
Query: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
G E +V+ T++ + +A L ++ + H + ER D+ K
Sbjct: 539 GDERT-------MVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKC 591
Query: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDG 354
PV+VAT G+D NV+ V ++++ ++ Y GR GR G
Sbjct: 592 PVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCG 635
>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
[Homo sapiens]
Length = 724
Score = 50.1 bits (118), Expect = 1e-05
Identities = 79/344 (22%), Positives = 135/344 (39%), Gaps = 40/344 (11%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL---LAKGIT------------IV 75
TP+Q+ + ++ G +D+ C TG+GK+ + LP L + GIT I+
Sbjct: 312 TPVQKYSIPIILAG-RDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECII 370
Query: 76 VSPLIALIQDQVDHLLTLKVRVSSLNSKLSA---QERKELLADLEREKPQTKILYITPEM 132
V+P L+ + L+ R S + + A +L + + IL TP
Sbjct: 371 VAPTRELVNQ-----IYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGR 425
Query: 133 AASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALT 192
+ + + YLV+DEA + G F P+ +L + L
Sbjct: 426 LMDIIGKEK----IGLKQIKYLVLDEADRMLDMG--FGPEMKKLISCPGMPSKEQRQTLM 479
Query: 193 ATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFC--LKAL 250
+AT + AA LK +F DVQ L + + L+ +
Sbjct: 480 FSATFPEEIQRLAAEFLKSNY-LFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNI 538
Query: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
G E +V+ T++ + +A L ++ + H + ER D+ K
Sbjct: 539 GDERT-------MVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKC 591
Query: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDG 354
PV+VAT G+D NV+ V ++++ ++ Y GR GR G
Sbjct: 592 PVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCG 635
>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
[Homo sapiens]
Length = 690
Score = 50.1 bits (118), Expect = 1e-05
Identities = 79/344 (22%), Positives = 135/344 (39%), Gaps = 40/344 (11%)
Query: 31 TPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL---LAKGIT------------IV 75
TP+Q+ + ++ G +D+ C TG+GK+ + LP L + GIT I+
Sbjct: 278 TPVQKYSIPIILAG-RDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECII 336
Query: 76 VSPLIALIQDQVDHLLTLKVRVSSLNSKLSA---QERKELLADLEREKPQTKILYITPEM 132
V+P L+ + L+ R S + + A +L + + IL TP
Sbjct: 337 VAPTRELVNQ-----IYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGR 391
Query: 133 AASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALT 192
+ + + YLV+DEA + G F P+ +L + L
Sbjct: 392 LMDIIGKEK----IGLKQIKYLVLDEADRMLDMG--FGPEMKKLISCPGMPSKEQRQTLM 445
Query: 193 ATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFC--LKAL 250
+AT + AA LK +F DVQ L + + L+ +
Sbjct: 446 FSATFPEEIQRLAAEFLKSNY-LFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNI 504
Query: 251 GQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKV 310
G E +V+ T++ + +A L ++ + H + ER D+ K
Sbjct: 505 GDERT-------MVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKC 557
Query: 311 PVIVATISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDG 354
PV+VAT G+D NV+ V ++++ ++ Y GR GR G
Sbjct: 558 PVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCG 601
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 49.3 bits (116), Expect = 2e-05
Identities = 71/300 (23%), Positives = 112/300 (37%), Gaps = 27/300 (9%)
Query: 622 GSAKSCSAQAEPPEPNEYDIP---PASHVYSLKPKRVGAGFPKGSCPFQTATELMETTRI 678
G+ K + P+ + +P AS + + V K S P + + + T
Sbjct: 253 GTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPG 312
Query: 679 REQAPQP----ERGGEHEPPSRPCGLL----DEDGS-EPLPGPRGEVPGGSAHYGGPSPE 729
+ A QP + G +PP++P GL + G+ +P P G + G P
Sbjct: 313 KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPP 372
Query: 730 KKAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAP----EAE 785
+ S SS G + Q A+ ++V +P LA P A+
Sbjct: 373 AQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAK 432
Query: 786 GACPSCEGVQGPPMAPEKYTGEEDGAGGHSPAPPQTEECLRERPSTCPPRDQGTPEVQPT 845
P+ VQ P P K ++ G G S ++ +P + P P QP
Sbjct: 433 APGPTKTPVQQP--GPGKIPAQQAGPGKTS-----AQQTGPTKPPSQLPGPAKPPPQQPG 485
Query: 846 PAKDTWK---GKRPRSQQENPESQPQKRPRPSAKPSVVAEVKGSVSASEQGTLNPTAQDP 902
PAK + +P SQQ P ++P P AKPS + + G+ P+AQ P
Sbjct: 486 PAKPPPQQPGSAKPPSQQPGSTKPPPQQPGP-AKPSPQQPGSTKPPSQQPGSAKPSAQQP 544
Score = 41.2 bits (95), Expect = 0.005
Identities = 63/313 (20%), Positives = 100/313 (31%), Gaps = 66/313 (21%)
Query: 617 PYDMGGSAKSCSAQAEPPEPNEY----DIPPASHVYSLKP--KRVGAGFPKGSCPFQTAT 670
P G K+ + Q P +P PP KP ++ G+ P P T
Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKP 509
Query: 671 ELMETTRIREQAPQPERGGEHEPPSRPCGLLDEDGSEPLPGPRGEVPGGSAHYGGPSPEK 730
+ + P P++ G +PPS+ G +P P PS ++
Sbjct: 510 PPQQPGPAK---PSPQQPGSTKPPSQQPGSAKPSAQQPSPAK-------------PSAQQ 553
Query: 731 KAKSSSGGSSLAKGRASKKQQLLATAAHKDSQSIARFFCRRVESPALLASAPEAE--GAC 788
K S S G+ + + +A SQ + + C + LL PE C
Sbjct: 554 STKPVSQTGS---GKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTC 610
Query: 789 PSCE-------GVQGPPMAPE-------KYTGEEDGAGGHSPAPPQTEECLRERPST--- 831
C+ G P E + G +P P + L+ P T
Sbjct: 611 TECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTS 670
Query: 832 -----CPPRDQGTPEVQPTPAKDTWKGKRPR-----------------SQQENPESQPQK 869
P Q +P+ P +D K P+ ++ PE+
Sbjct: 671 AVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLS 730
Query: 870 RPRPSAKPSVVAE 882
+P P +PSV +E
Sbjct: 731 KPAPPKEPSVPSE 743
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,921,920
Number of Sequences: 37866
Number of extensions: 2415679
Number of successful extensions: 12631
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 535
Number of HSP's that attempted gapping in prelim test: 10947
Number of HSP's gapped (non-prelim): 1955
length of query: 991
length of database: 18,247,518
effective HSP length: 112
effective length of query: 879
effective length of database: 14,006,526
effective search space: 12311736354
effective search space used: 12311736354
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.