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Search of human proteins with 148596984
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
(3259 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 6191 0.0
gi|55770834 centromere protein F [Homo sapiens] 310 1e-83
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 306 2e-82
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 306 3e-82
gi|21735548 centrosomal protein 2 [Homo sapiens] 296 2e-79
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 284 1e-75
gi|71061468 centromere protein E [Homo sapiens] 279 3e-74
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 263 2e-69
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 234 8e-61
gi|33188443 microfilament and actin filament cross-linker protei... 229 3e-59
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 227 2e-58
gi|148746195 trichohyalin [Homo sapiens] 225 5e-58
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 223 3e-57
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 222 4e-57
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 220 2e-56
gi|221316624 dystonin isoform 4 [Homo sapiens] 218 1e-55
gi|221316622 dystonin isoform 3 [Homo sapiens] 218 1e-55
gi|221316618 dystonin isoform 2 [Homo sapiens] 218 1e-55
gi|34577047 dystonin isoform 1 [Homo sapiens] 218 1e-55
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 218 1e-55
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 216 4e-55
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 214 9e-55
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 214 9e-55
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 214 9e-55
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 214 9e-55
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 214 9e-55
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 214 9e-55
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 214 9e-55
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 214 9e-55
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 214 9e-55
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 6191 bits (16061), Expect = 0.0
Identities = 3259/3259 (100%), Positives = 3259/3259 (100%)
Query: 1 MLSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQL 60
MLSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQL
Sbjct: 1 MLSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQL 60
Query: 61 VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120
VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT
Sbjct: 61 VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120
Query: 121 VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180
VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST
Sbjct: 121 VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180
Query: 181 EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL 240
EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL
Sbjct: 181 EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL 240
Query: 241 VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME 300
VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME
Sbjct: 241 VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME 300
Query: 301 AEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE 360
AEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE
Sbjct: 301 AEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE 360
Query: 361 SRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI 420
SRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI
Sbjct: 361 SRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI 420
Query: 421 QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL 480
QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL
Sbjct: 421 QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL 480
Query: 481 ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA
Sbjct: 481 ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
Query: 541 EESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ 600
EESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ
Sbjct: 541 EESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ 600
Query: 601 MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE 660
MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE
Sbjct: 601 MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE 660
Query: 661 LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN 720
LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN
Sbjct: 661 LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN 720
Query: 721 LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQR 780
LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQR
Sbjct: 721 LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQR 780
Query: 781 RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL 840
RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL
Sbjct: 781 RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL 840
Query: 841 QNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKD 900
QNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKD
Sbjct: 841 QNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKD 900
Query: 901 QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK
Sbjct: 901 QQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK 1020
QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK
Sbjct: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK 1020
Query: 1021 DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080
DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL
Sbjct: 1021 DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDL 1080
Query: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL
Sbjct: 1081 EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1260
LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1260
Query: 1261 PGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE 1320
PGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE
Sbjct: 1261 PGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE 1320
Query: 1321 LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ 1380
LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ
Sbjct: 1321 LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ 1380
Query: 1381 IAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALH 1440
IAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALH
Sbjct: 1381 IAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALH 1440
Query: 1441 TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK 1500
TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK
Sbjct: 1441 TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK 1500
Query: 1501 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560
SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL
Sbjct: 1501 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560
Query: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620
ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ
Sbjct: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620
Query: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK 1680
SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRK 1680
Query: 1681 FAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSK 1740
FAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSK
Sbjct: 1681 FAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSK 1740
Query: 1741 KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ
Sbjct: 1741 KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK 1860
DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK
Sbjct: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK 1860
Query: 1861 EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKD 1920
EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKD
Sbjct: 1861 EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKD 1920
Query: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT 1980
DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT
Sbjct: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT 1980
Query: 1981 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040
KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER
Sbjct: 1981 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040
Query: 2041 TVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK 2100
TVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK
Sbjct: 2041 TVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK 2100
Query: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160
LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160
Query: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
Query: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 2281 TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG 2340
TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG 2340
Query: 2341 IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA 2400
IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA
Sbjct: 2341 IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA 2400
Query: 2401 ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD
Sbjct: 2401 ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
Query: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520
SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520
Query: 2521 DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2580
DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE
Sbjct: 2521 DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2580
Query: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 2641 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET 2700
VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET
Sbjct: 2641 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET 2700
Query: 2701 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2760
AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK
Sbjct: 2701 AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2760
Query: 2761 YDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHL 2820
YDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHL
Sbjct: 2761 YDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHL 2820
Query: 2821 SSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
SSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK
Sbjct: 2821 SSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Query: 2881 KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ 2940
KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ 2940
Query: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP 3000
ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP
Sbjct: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP 3000
Query: 3001 LKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
LKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE
Sbjct: 3001 LKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGV 3120
EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGV
Sbjct: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGV 3120
Query: 3121 HRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR 3180
HRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR
Sbjct: 3121 HRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRR 3180
Query: 3181 LEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLA 3240
LEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLA
Sbjct: 3181 LEHSEWDSSRTPIIGSCGTQEQALLIDLTSNSCRRTRSGVGWKRVLRSLCHSRTRVPLLA 3240
Query: 3241 AIYFLMIHVLLILCFTGHL 3259
AIYFLMIHVLLILCFTGHL
Sbjct: 3241 AIYFLMIHVLLILCFTGHL 3259
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 310 bits (794), Expect = 1e-83
Identities = 637/3191 (19%), Positives = 1290/3191 (40%), Gaps = 496/3191 (15%)
Query: 52 ERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADN-KIKKLKLHAK-AKLTSLNK 109
+++ E + +LK +Q+ QL + ALQ++++ +N K + L + +L + +
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE 77
Query: 110 YIEEMKAQGGTVLPTEPQS----EEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA 165
+E+ K + L + E QL+ K + E E+++ K +L+ ++ +
Sbjct: 78 SLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADV 137
Query: 166 QLTQAQAEQ--------PAQ--SSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
L Q P+Q S ++ E+ +K++ ++ E L+A++ QA++A+
Sbjct: 138 SLNPCNTPQKIFTTPLTPSQYYSGSKYED---LKEKYNKEVEERKRLEAEVKALQAKKAS 194
Query: 216 QQV----VREKD-ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 270
Q + + +D AR + + + + + ++ R E+ +
Sbjct: 195 QTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTP 254
Query: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET--------ERE------- 315
+ + +++ ++ N L Q++A++ LRN + E+E
Sbjct: 255 SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNK 314
Query: 316 --ESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAE 373
E ++ LEK ++E+ E++ + ++E+ Q++QA ++Y+ALEQK K
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAS-------TKYTALEQKLK-- 365
Query: 374 MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKE 433
KL +D + Q + LE ++++K KE
Sbjct: 366 ------------------------------KLTEDLSCQRQNAESARCSLEQKIKEKEKE 395
Query: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
+ L+R Q SF Q + +E I + EL+ K + E
Sbjct: 396 FQEELSR---------QQRSF--------QTLDQECIQMKARLTQELQQAKNMHNVLQAE 438
Query: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
L++L + ++L + + + + E + S+I N+ S EE + EN
Sbjct: 439 LDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK----ENELRRSMEEMKK---ENNLL 491
Query: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613
+ H E ++A E H + K +KQ +
Sbjct: 492 KSHSE------------------------QKAREVCHLEAELKNIKQCLNQS-------- 519
Query: 614 FLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
++ ++ + ++ +E+ + + S T E++ L A +E K
Sbjct: 520 --QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE---------KQRD 568
Query: 674 AVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD 733
D+ + + +E+L ++ + E K + L+ K KE L + F
Sbjct: 569 CSQDLLKKREHHIEQLNDKLSKTE----KESKALLSALELKKKEYEELKEEKTLFSCWKS 624
Query: 734 NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793
N T + E++ L S++ L + + Q+K E N
Sbjct: 625 ENEKLLTQMESEKENLQSKINHLETCLKTQ-QIKSHEYN--------------------- 662
Query: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQL----QNKESEVLE 849
E++ +L ++ ++ V+I L N LD ++ Q LQ + Q + E+
Sbjct: 663 --ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS 909
+ ++ +VE+L L EI D+ + + E+L+ ++ KD + +
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT-NED 779
Query: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA 969
++ +++ + EQ ++ S E + E + + +S + QN +
Sbjct: 780 HQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEA--DQSPKNSAILQNRVDSLEF 837
Query: 970 GQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL--------LQRVSRLEE------- 1014
S++++ + +E Q K +++ L+ +++ QR+S+L+E
Sbjct: 838 SLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQN 897
Query: 1015 ---ELANLKDESKKEIPLS----ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS 1067
E + + +KE+ L ETE+ E++E K++ E + +E+++ L +T+S
Sbjct: 898 VVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL----KELQL-LSETLS 952
Query: 1068 EKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDK-----------TNQIDLLQAEIS 1116
++ E+ I + ++ Q +K++N +L + N ID + IS
Sbjct: 953 LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012
Query: 1117 E--NQAIIQKLI-------TSNT--DASDGDSVALVKETVV--ISPPCTGSSEHWKPELE 1163
E +Q +KLI T N D S A K + + + CT E+ K ELE
Sbjct: 1013 ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072
Query: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS 1223
+ A KE ++ KL A + ++ + + ++ LR E+ D+ N + +
Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT---DNQNNSKSEAGGLK 1129
Query: 1224 KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLE-EPLFKATEQHHTQPVLES 1282
+E + ++ ++Q +V + + ++ LE EP+ + ++ ++ +
Sbjct: 1130 QEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERN-QC 1188
Query: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQL--KEIEAEKVELELKVSSTTSELTKKSEEVF 1340
N P ++ S + Q++A L KE++ ++ E E + + + E
Sbjct: 1189 NFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETS 1248
Query: 1341 QLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLRELQPKLDELQK 1399
LQ+ Q EI LK +AE S +L +SQ A L+ L+ KL+EL+K
Sbjct: 1249 NLQDM---QSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEK 1305
Query: 1400 LI----SKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK 1455
+ ++K E V+ L+ SE A K+ E+ + + +K L+ + H E ++
Sbjct: 1306 ICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLL---HGELVE 1362
Query: 1456 QLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIER 1515
+ E ++P E S A + +S KE LQE+ +++
Sbjct: 1363 DIPGG--EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL----SLQS 1416
Query: 1516 LTKSLADVESQVSAQNKEKDTVLGRLAL--------LQEERDKLITEMDRSLLEN--QSL 1565
K L D Q+S++ E T + L L+ + L+ EM L E SL
Sbjct: 1417 EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSL 1476
Query: 1566 SSSC--ESLKLALEGLTEDKEKLVKE------IESLKSSKIAESTEWQEKH-KELQKEYE 1616
SSSC +S L+ G + L+++ + +L+ + A E LQ+E
Sbjct: 1477 SSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENL 1536
Query: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676
++ + E ++ + E RQ ++L K+ S K K++QE EQ + ++
Sbjct: 1537 TRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN---KEIQELEQLLSSERQ 1593
Query: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE 1736
++ K Q + E E+ +L + ME+ L A+ K++ E++ +E E
Sbjct: 1594 ELDCLRK---QYLSENEQWQQKLTSVTLE--------MESKL---AAEKKQTEQLSLELE 1639
Query: 1737 TLSKKFQSL-MSEKDSLSEEVQDLKHQIEG-----NVSKQANLEATE---KHDNQTNVTE 1787
+ Q L +S + L + +D I+G ++SK+ E TE KHD +
Sbjct: 1640 VARLQLQGLDLSSRSLLGIDTEDA---IQGRNESCDISKEHTSETTERTPKHDVHQICDK 1696
Query: 1788 EGTQSIPGETEEQDSLSMSTRPT--CS-ESVPSAKSANPAVSKDFSSHDEIN-------N 1837
+ Q + + E+ + +PT CS E P P K S + I+ N
Sbjct: 1697 DAQQDLNLDIEKITETG-AVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
Query: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV----TK 1893
L +D L G +E+ + + NE LL I +D +++ L E+ +K
Sbjct: 1756 ALVPMDFL-----GNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSK 1810
Query: 1894 MNLLNQQIQEELSRVTKLKETAEE---EKDDLEERL---------MNQLAE----LNGSI 1937
++L Q+ ++ +L++ E E DL E+L + Q E LN +
Sbjct: 1811 LHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDL 1870
Query: 1938 GNYC-----QDVTDAQIK-NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
+ +D+ D K N+ + +++ +S + EK + E +E+++
Sbjct: 1871 EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQT 1930
Query: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
EK+ + + L+E L E QL+ + +K +AL++ + ++ E
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK----E 1986
Query: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
++LE + ++ A+AE+ LL S+ + +L D L+++LQS
Sbjct: 1987 KTQELESHQSECLHCIQ---VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS---- 2039
Query: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDK 2171
LE+ + K ++ ++ L +EK L + +Q L++ D
Sbjct: 2040 ---------------LEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 2172 EVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKED 2231
E + + L++ + + F +SS Q++ + + ++ K I++ E++ +L
Sbjct: 2085 EKLNVSKALEAALVEKGEFALRLSSTQEE----VHQLRRGIEKLRVRIEADEKK-QLH-- 2137
Query: 2232 NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS 2291
+ ++L++ + LK + LE + Q+ E + + + + E + L +
Sbjct: 2138 ----IAEKLKERERENDSLKDKVENLERELQMSEENQELVIL----DAENSKAEVETLKT 2189
Query: 2292 QLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE-ADIQ 2350
Q+EE + +L L SE ++L Q+ + L + + + + ++ ++E A+IQ
Sbjct: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 2351 ---NSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD 2407
SK + E L+ L+ E + L +Q+I + E+++ I E Q +
Sbjct: 2250 IKEESKTAVEMLQNQLKELNEAVAAL-----CGDQEI---MKATEQSLDPPIEEEHQLRN 2301
Query: 2408 KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE-----NIQQKAQLDSF 2462
I++L L +E++ + + ++ K++ + L ++ +++E Q+ A L++
Sbjct: 2302 S-IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA- 2359
Query: 2463 VKSMSSLQNDRDRIVGDYQQLEERHLSIIL---EKDQLIQEAAAENNKLKEEIRGLRSHM 2519
S ++ + +I G Q L L ++ EK+ L E E ++ E + + S
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISE-LEIINSSF 2418
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKES 2579
+++ E + E +Q +E K S ++L+ QL KEL + A L +
Sbjct: 2419 ENILQEK---EQEKVQMKE--------KSSTAMEMLQTQL---KELNERVAALHNDQEAC 2464
Query: 2580 EEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEE 2639
+ ++L L+ EK L + ++ K + L V L +E G +L+ K+E
Sbjct: 2465 KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG--KQKLEKKDE 2522
Query: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699
E+ RL K + +E+LV K+ ++E E +
Sbjct: 2523 EISRL--------KNQIQDQEQLV-------SKLSQVE------------------GEHQ 2549
Query: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR 2759
+E+ EL VE+EQK+ ++ +N L ++ S +L+N + +
Sbjct: 2550 LWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVE 2609
Query: 2760 KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLS-HLEKLNQQLLSKDEQLL 2818
K + + +L+ + ++ A L E S E+N L+ L+ L +++ S +QL
Sbjct: 2610 KVNKMTAKETELQREMHEMAQKTAELQEEL----SGEKNRLAGELQLLLEEIKSSKDQLK 2665
Query: 2819 HLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQS 2878
L+ + + + K + + E + E K ++ + EV+
Sbjct: 2666 ELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVE- 2724
Query: 2879 LKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEEL 2938
+Q R++L + + L Q L+I+ LK+ +E + KA + EEL
Sbjct: 2725 -------IQTYREKLTSKEECLSSQKLEIDL-------LKSSKEELNNSLKATTQILEEL 2770
Query: 2939 RQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQT 2998
++ + ++QL+ E +ER + L+ S K QL + + L+ SQ
Sbjct: 2771 KKTKMDNLKYVNQLKKE------NERAQGKMKLLIKSCK--QLEEEKEI---LQKELSQL 2819
Query: 2999 QPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQL 3058
Q + + + +T L E + L+ L + KE + + L + +L
Sbjct: 2820 QAAQEKQKTGTVMDTKV-----DELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
Query: 3059 LEEKNTLSIQL 3069
+ K L Q+
Sbjct: 2875 EKAKEMLETQV 2885
Score = 300 bits (768), Expect = 2e-80
Identities = 561/2826 (19%), Positives = 1158/2826 (40%), Gaps = 396/2826 (14%)
Query: 111 IEEMKAQGGTVLPTEPQSEEQLSKHDKSST-------EEEMEIEKIKHKLQEKEELISTL 163
++++KAQ + + E +L H+K E ++++EK K +L EKE++++
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 164 QAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD 223
+ +L + A+ Q+ST+ + ++Q+L++ E +S Q Q +++ A + +Q ++EK+
Sbjct: 340 RDELVRTTAQYD-QASTK---YTALEQKLKKLTEDLSC-QRQNAES-ARCSLEQKIKEKE 393
Query: 224 ARFETQVRLHEDELLQLVTQA-DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL 282
F+ ++ + L + ++ + Q+L+ + + L V L+ L
Sbjct: 394 KEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453
Query: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEM 342
+Q+ Q Q + + N LR ++E ++E+ +L E + E +L+ E+
Sbjct: 454 EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE----VCHLEAEL 509
Query: 343 HHLLEQFEQAGQAQAELESRYSALEQ-----KHKAEMEEKTSHILSLQKTGQELQSACDA 397
++ + Q+ E++++ ++ E + K +E + + L+ +L+ D
Sbjct: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE----TASQTS 453
+D LL+ + I+QL D+L + KE L+ L L++ E +T
Sbjct: 570 SQD----LLKKREHH-------IEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTL 618
Query: 454 FPDVYNEGTQAVT--EENIASLQKRVVELENEKGALLLSSIELEE----LKAENEKLSSQ 507
F +E + +T E +LQ ++ LE + S E E L+ + E LS +
Sbjct: 619 FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVE 678
Query: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKH-KELSVLLLEM 566
I L + + E +++ +++ K S QKH KE+ + L+
Sbjct: 679 IRNLHNVLDSKSVEVETQKLAYMELQQKAEFS-------------DQKHQKEIENMCLKT 725
Query: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ---MEGEGIAPI-KMKVFLEDTGQDF 622
+ ++ L+ +LQ +E++D+ Q E E + + K K T +D
Sbjct: 726 SQLTGQVEDLEHKLQ-----LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 623 ----------PLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSL 672
P M + +++ + S + R + S ++ + L++ + SL
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-LQNRVDSLEFSL 839
Query: 673 SAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNA 732
+ + Q + E L E+E N KA+++++ + E ++ IS L +
Sbjct: 840 ESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQE--------- 890
Query: 733 DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
+ S+ ++E L ++ KEL ++ + +V+ + + E ++ L E
Sbjct: 891 -DTSAHQNVVAETLSALENKEKELQLLND---KVETEQAEIQELKKSNHL-LEDSLKELQ 945
Query: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
LL+E +LS+E K I + + E++++ + + SL + N + A
Sbjct: 946 LLSE---TLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
Query: 853 RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQV-------TE 905
+ + ELS Q++L + + + D+ + +EK+ ++ T
Sbjct: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
Query: 906 ISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE 965
+ + ++ QL E K +E L L+ AEE + + E V L+ E
Sbjct: 1063 LCENRKNELEQLKE------AFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRS---E 1113
Query: 966 MSPAGQISKEE---LQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDE 1022
M+ SK E L+ E LK+E + ++++ L+ E L +V + + E NL+ E
Sbjct: 1114 MTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVND-LLQENEQLMKVMKTKHECQNLESE 1172
Query: 1023 S-KKEIPLSETERGEV----EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIR 1077
+ + E+ER + + D E KE S ++ ++E L+ KE++LQ
Sbjct: 1173 PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRN----KELKLQESE 1228
Query: 1078 KDLEEKLAAEEQFQALVKQMNQT-LQDKTNQ--IDLLQAEISENQAIIQKLITSNTDASD 1134
K EK + + Q + + + LQD +Q L EI + I +T +D
Sbjct: 1229 K---EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQND 1285
Query: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194
+ +T + + ELE+ L+ EK +L +L ++ + +K
Sbjct: 1286 NAHLQCSLQTTM----------NKLNELEKICEILQAEKYELVTELNDSRSECITATRKM 1335
Query: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQ----IQVRESIDGKLPS 1250
E+ L E+K DD L + E E G+Q + + ES + +
Sbjct: 1336 AEEVGKLLNEVKILNDDSGLLHGELVEDIPGGE-FGEQPNEQHPVSLAPLDESNSYEHLT 1394
Query: 1251 TDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQ 1310
+E L+E +H +L C Q + +++++
Sbjct: 1395 LSDKEVQMHFAELQEKFLSLQSEHK---ILHDQHC-------------QMSSKMSELQTY 1438
Query: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL 1370
+ ++AE + L + + +L K+ + GLE + ++S + SL
Sbjct: 1439 VDSLKAENLVLSTNLRNFQGDLVKEMQ-----------LGLEEGLVPSLSSSCVPDSSSL 1487
Query: 1371 QQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE-- 1428
L S A LE ++ L L+ +S + V + S +E LT+ +T
Sbjct: 1488 SS-LGDSSFYRALLEQTGDMS-LLSNLEGAVSANQCSVDEVFCS-SLQEENLTRKETPSA 1544
Query: 1429 ----IIEQEDL-------IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
+ E E L ++ L ++E Q ++ I++L+ L +Q+ + + ++ +
Sbjct: 1545 PAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLS 1604
Query: 1478 K-QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
+ +Q Q+KL + + + L K E+LSL + RL D+ S+ +D
Sbjct: 1605 ENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL-EVARLQLQGLDLSSRSLLGIDTEDA 1663
Query: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCES-----LKLALEGLTEDKE-KLVKEI 1590
+ GR ++ +R+ + C+ L L +E +TE K E
Sbjct: 1664 IQGRNESCDISKEHTSETTERT--PKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGEC 1721
Query: 1591 ESLKSSKIAESTEWQEKHK-------EL----------------QKEYEILLQSYENVSN 1627
+S ++K + EL Q++ L + SN
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
Query: 1628 EAERIQHV-------VEAVRQEKQELYGKLRSTEANKK-------ETEKQLQEAEQEMEE 1673
E R+ HV VE++ E +EL KL E E EK + E ++E +
Sbjct: 1782 ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSD 1841
Query: 1674 MKEKMRKFAKSKQQKILELEEENDRLRA--EVHPAGDTAKECMETLLSSNASMKEELERV 1731
+ EK+ F+ Q++L+ E ++ L + E+H + ++ + + N S KE V
Sbjct: 1842 LSEKLEYFS-CDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDV 1900
Query: 1732 KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
+ E + SEK S+ E L+ +E +++ LE DN E Q
Sbjct: 1901 ENE-------LSRIRSEKASIEHEALYLEADLEVVQTEKLCLEK----DN------ENKQ 1943
Query: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851
+ EE+ S+ S R N ++D + ++
Sbjct: 1944 KVIVCLEEELSVVTSER---------------------------NQLRGELDTMSKKTTA 1976
Query: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1911
L++ +K KE +Q LE+ ++ L I + E+K E+ + L+ + E L T L
Sbjct: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK---EKTELLQTLSSDVSELLKDKTHL 2033
Query: 1912 KETAEEEKDDLEE------RLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCV 1965
+E + + D + L NQ+A+LN + ELL E ++L+ +
Sbjct: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNK--------------EKELLVKESESLQARL 2079
Query: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025
SE + EK V + +EK + A + + +L+ +++ + ++ +
Sbjct: 2080 SESDYEK-------LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE 2132
Query: 2026 KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
K + EK+ ER +L+ +++L++++EN + + ++AE+ + K ++
Sbjct: 2133 KKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIE 2192
Query: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE------DLERRLEQAEEKHLKEKK 2139
+ D + L+ E ++ + ++ + Q E + LE+ E+ ++ K+
Sbjct: 2193 EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKE 2252
Query: 2140 NMQEKLDALRREKVHLEETIGEI----------QVTLNKKDKEVQQLQENLDSTVTQLAA 2189
+ ++ L+ + L E + + + +L+ +E QL+ +++ +L A
Sbjct: 2253 ESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
Query: 2190 FTKS-------MSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS----VLKD 2238
K + + D + + ER+ A ++ +E L+ +N LK
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA-RTNQEHAALEAENSKGEVETLKA 2371
Query: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETR- 2297
++ M+ + L++++ + +K+ ++ Q E + ++ + + + +L + E+ +
Sbjct: 2372 KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL-EIINSSFENILQEKEQEKV 2430
Query: 2298 HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEAD-------IQ 2350
+ S + L+++LK L +++ L N E CK ++ NL + E + +
Sbjct: 2431 QMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLD 2490
Query: 2351 NSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA--IAELRQQHD- 2407
+K +Y L++ + + +++ K+++I L + ++ Q+ ++++ +H
Sbjct: 2491 EAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQL 2550
Query: 2408 --KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS 2465
++ EL NL + E++ VL+ +N D L + K ++ E K SFV+
Sbjct: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK 2610
Query: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
++ + + + ++ ++ + E A E L EEI+ + + +L E
Sbjct: 2611 VNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLE 2670
Query: 2526 NAKLDAELI-----------QYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE 2574
N++L L + RE++ + +K+ + L NK+ E + E
Sbjct: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
Query: 2575 KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR-QVTALQEEGTLGLYHAQ 2633
KL EE + + L+ K++L+ +++ + +L + ++ L+ Y Q
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLK-------YVNQ 2783
Query: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA--------KKVGEI----EDKLK 2681
LK + E L S K +LEEE +QKE + +K G + D+L
Sbjct: 2784 LKKENERAQGKMKLLIKSCK---QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELT 2840
Query: 2682 KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741
E+K L + +T+ A+E + + L+ E+ + K + L Q+ S
Sbjct: 2841 TEIKELKE---TLEEKTKEADEYLDKYCSLLISHEK----LEKAKEMLETQVAHL-CSQQ 2892
Query: 2742 SLQNSR 2747
S Q+SR
Sbjct: 2893 SKQDSR 2898
Score = 285 bits (728), Expect = 7e-76
Identities = 531/2642 (20%), Positives = 1090/2642 (41%), Gaps = 359/2642 (13%)
Query: 26 MRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ-- 83
M+A L EL Q +M +N Q ++ + + +QL L++ +QK + +Q +A Q
Sbjct: 417 MKARLTQELQQAKNM--HNVLQAELDKLTSVKQQLENNLEEF-KQKLCRAEQAFQASQIK 473
Query: 84 -EERKAADNKIKK----LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138
E + + ++KK LK H++ K + E+K + ++ +EE +K+
Sbjct: 474 ENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN--- 530
Query: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198
T +E + ++ K+ ++E ++ + +L A E+ S ++ L+++E
Sbjct: 531 -TSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL---------LKKREHH 580
Query: 199 ISTLQAQLSQTQAEQAAQQVVRE-KDARFE------TQVRLHEDELLQLVTQADVETE-M 250
I L +LS+T+ E A E K +E T + E +L+TQ + E E +
Sbjct: 581 IEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL 640
Query: 251 QQKLRVLQ-----------------RKLEEHEESL---------VGRAQVVDLLQQELTA 284
Q K+ L+ R LE E+L V ++ V++ Q+L
Sbjct: 641 QSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAY 700
Query: 285 AE-QRNQILSQQLQQMEAEHNTLRNTVETER-EESKILLEKMELEVAERKLSFHNLQEEM 342
E Q+ S Q Q E E+ L+ + T + E+ + L+ + E+ ++ + +L E
Sbjct: 701 MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY 760
Query: 343 HHLLEQFEQAGQAQAELESRY-SALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQ 401
L + + + E S L + M ++I+ Q + +S C DQ
Sbjct: 761 ESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 402 ---NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL------QQH-----E 447
NS +LQ++ + S ++ +Q+ LQ++ +E+ Q + Q H E
Sbjct: 821 SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE 880
Query: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQ 507
T+ + S Q V E +++L+ + EL+ + E++ELK N L
Sbjct: 881 TSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDS 940
Query: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567
+ L+ + T +++ E+S + NKR EE Q+ T + + L+ + +
Sbjct: 941 LKELQLLSETLSLEKK--EMSSIISLNKRE--IEELTQE--NGTLKEINASLNQEKMNLI 994
Query: 568 EAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627
+ E A E++ E+ DQ + +++ + E+TG +
Sbjct: 995 QKSESFANYI-----DEREKSISELSDQYKQEKLI--------LLQRCEETGNAY----- 1036
Query: 628 EESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDEL- 686
E+ S +K +A+ E S+ E LN+ ++ K + ++ A + HQ+ L
Sbjct: 1037 EDLS----QKYKAAQEKNSKL--ECLLNECTSLCENRKNELEQLKEA---FAKEHQEFLT 1087
Query: 687 ------ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFT 740
ER ++ +LELE + N + E L Q I K+ +
Sbjct: 1088 KLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVN 1147
Query: 741 ALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQR-----RLDYESQTAHDNLLT 795
L +E +QL+ +K L ++ + + E+ER + ++D E + +
Sbjct: 1148 DLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYN 1207
Query: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ-SQLQNKESEVLEGAE-- 852
Q+ L ++K++K++ + E + +Q E T+ L+ S LQ+ +S+ + G +
Sbjct: 1208 AQLVQLEAMLRNKELKLQESEKEKECLQ---HELQTIRGDLETSNLQDMQSQEISGLKDC 1264
Query: 853 ----RVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE-EKDQQVTEIS 907
++IS E + L+ + Q + K ++E + + ++ EK + VTE++
Sbjct: 1265 EIDAEEKYISGPHELSTSQNDNAHLQCSL--QTTMNKLNELEKICEILQAEKYELVTELN 1322
Query: 908 FSMTEKMV---QLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
S +E + ++ EE L E+K L + LL E VE+
Sbjct: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHG------ELVED------------- 1363
Query: 965 EMSPAGQISKE-ELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
P G+ ++ QH L + L ++ KE+ + L+E+ +L+ E
Sbjct: 1364 --IPGGEFGEQPNEQHPVSLAPLDESNSYEHLT---LSDKEVQMHFAELQEKFLSLQSEH 1418
Query: 1024 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV---ELQHIRKDL 1080
K + D+ + ++SK E++ Y+ +E V L++ + DL
Sbjct: 1419 K------------ILHDQHCQ------MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL 1460
Query: 1081 --EEKLAAEEQFQALVKQMNQT-------------------LQDKTNQIDLL---QAEIS 1116
E +L EE LV ++ + L ++T + LL + +S
Sbjct: 1461 VKEMQLGLEE---GLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVS 1517
Query: 1117 ENQAIIQKLITS-----NTDASDGDSVAL--VKETVVISPPCTGSSEHWKPELEEKILAL 1169
NQ + ++ S N + S V+E + S E + ++E + +
Sbjct: 1518 ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMK 1577
Query: 1170 EKEKEQLQKKL----QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKE 1225
KE ++L++ L QE RK L + ++ ++ L + + ++Q ++ S E
Sbjct: 1578 NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE 1637
Query: 1226 NENIGDQLRQLQIQVRE--SIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESN 1283
E QL+ L + R ID + + ESC + + T +H + + +
Sbjct: 1638 LEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKD 1697
Query: 1284 LCPDWPSHSE------------DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTS- 1330
D E + S Q + + + K + + EL S +
Sbjct: 1698 AQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757
Query: 1331 ---ELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHL 1387
+ E++ LQ ++ + E L V + + ESL +++ ++ HL
Sbjct: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKL----HL 1813
Query: 1388 RELQ--PKLD---ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQ 1442
+E+Q K++ EL+K++ + +++ S LSEK + E++++ + + L++
Sbjct: 1814 QEVQLMTKIEACIELEKIVGELKKENS----DLSEKLEYFSCDHQELLQRVETSEGLNSD 1869
Query: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGE------ESRAKQQIQRKLQAALISRKEAL 1496
LEM A K E+IG+ +S ++ + + + + I ++A
Sbjct: 1870 LEMHAD----------------KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913
Query: 1497 KENKSLQEELSLARGTIERLT---------KSLADVESQVSAQNKEKDTVLGRLALLQEE 1547
E+++L E L E+L K + +E ++S E++ + G L + ++
Sbjct: 1914 IEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKK 1973
Query: 1548 R---DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEW 1604
D+L +M E +S S C E ++K +L++ + S S + + T
Sbjct: 1974 TTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033
Query: 1605 QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQL 1664
QEK + L+K+ + L + + N+ ++ E + +E + L +L ++ K K L
Sbjct: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKAL 2093
Query: 1665 QEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLS---SN 1721
+ A E E ++ S Q+++ +L ++LR + E L N
Sbjct: 2094 EAALVEKGEFALRL----SSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREN 2149
Query: 1722 ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE--GNVSKQANLEATEKH 1779
S+K+++E ++ E + + + ++ + ++ EV+ LK QIE K L+
Sbjct: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 1780 DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYL 1839
+ N+T++ Q G+ E D L S + E + A + ++ S +
Sbjct: 2210 SEKENLTKQ-IQEKQGQLSELDKLLSSFKSLLEEK----EQAEIQIKEE--SKTAVEMLQ 2262
Query: 1840 QQIDQLKERIAGLEEEKQKNKEFSQTLE----------NEKNTLLSQISTKDGE----LK 1885
Q+ +L E +A L +++ K Q+L+ N L +++ + + L+
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Query: 1886 MLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVT 1945
L+E +LL ++ E L R ++ T +E E ++ L I Q +
Sbjct: 2323 QLKESEHHADLLKGRV-ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLR 2381
Query: 1946 DAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKS 2005
++ + SE +NL + + +E +L + E+ ++++ EK+Q +K + +
Sbjct: 2382 GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK---SST 2438
Query: 2006 HAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQ 2065
+ LQ LKE + V L D + K L V+ LE + + + L+ K N
Sbjct: 2439 AMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIV 2498
Query: 2066 AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER 2125
E+ K L+ E +R LK ++Q ++ V + + E
Sbjct: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISR-------LKNQIQDQEQLVSKLSQVEGEHQLW 2551
Query: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185
+ + E ++L + +++K+ L+ + L++T+ +Q + + E++ + + S V
Sbjct: 2552 KEQNLELRNLTVE--LEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVE 2609
Query: 2186 QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSI 2245
++ T + LQ + + + + + + S E++L + KDQL+++++
Sbjct: 2610 KVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTL 2669
Query: 2246 HMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQN 2305
ELK ++ + D+ E K + E+ Q + +++ LL +
Sbjct: 2670 ENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNK---------- 2719
Query: 2306 ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQA 2365
+ E E+++ +++LT S E+C + Q+ +I K S E+L L+A
Sbjct: 2720 ---QYEVEIQTYREKLT----SKEEC----------LSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 2366 SRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENI 2425
+ ++ L ++ M K ++ L + E Q + +L + K+++E + +L +E +
Sbjct: 2763 TTQILEEL-KKTKMDNLKYVNQLKKENERAQGKM-KLLIKSCKQLEEEKEILQKELSQLQ 2820
Query: 2426 VLEEENKKAV---DKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQ 2482
+E+ K K ++L +K +K+ ++ + D ++ SL +++ +
Sbjct: 2821 AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
Query: 2483 LE 2484
LE
Sbjct: 2881 LE 2882
Score = 253 bits (645), Expect = 3e-66
Identities = 511/2657 (19%), Positives = 1038/2657 (39%), Gaps = 490/2657 (18%)
Query: 961 QNYDEMSPAGQISK-EELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANL 1019
+ + E P + K +EL+ + D LKKE +QR+ +L + ++ Q+V + E NL
Sbjct: 6 EEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL 65
Query: 1020 KDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079
K E+++ + + E+ ++ + E V + ++ KQ I + E EL+ + +
Sbjct: 66 KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQ-IEKLEQELKRCKSE 124
Query: 1080 LEEKLAAEEQFQALVKQMN---------------------QTLQDKTN----QIDLLQAE 1114
LE A + + N + L++K N + L+AE
Sbjct: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAE 184
Query: 1115 ISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKE 1174
+ QA AS A + + + S W+ E L+ ++
Sbjct: 185 VKALQA---------KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRT 235
Query: 1175 QLQKKL--------QEALTSRKAILKKAQEKER---------HLREELKQQKDDY----N 1213
+++ QE SR + ++ HL ++LK Q + N
Sbjct: 236 PIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQ 1273
L+ + KE + ++ ++LQ+Q+ ++ + C + L + T Q
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC------RDELVRTTAQ 349
Query: 1274 HHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELT 1333
+ + L +ED S + A+ + K E EK E + ++S
Sbjct: 350 YDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEK-EFQEELSRQQRSFQ 408
Query: 1334 KKSEEVFQLQEQINKQ-----------GLEIESLKTVSHEAEVHAESLQQKL-------E 1375
+E Q++ ++ ++ E++ L +V + E + E +QKL +
Sbjct: 409 TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468
Query: 1376 SSQLQIAGLEHLRELQPKLDELQKLISK-KEEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434
+SQ++ L E K + L K S+ K +V +L +L + L + Q E
Sbjct: 469 ASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE--- 525
Query: 1435 LIKALHTQLEMQAKEHDERIKQLQVELC--EMKQKPEEIGEESRAKQQIQRKLQAALISR 1492
+KA +T E ++ E+I Q + L ++K ++ ++ Q + +K + +
Sbjct: 526 -MKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 1493 KEAL----KENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEER 1548
+ L KE+K+L L L + E L KE+ T+ + + E
Sbjct: 585 NDKLSKTEKESKALLSALELKKKEYEEL---------------KEEKTLF---SCWKSEN 626
Query: 1549 DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKH 1608
+KL+T+M+ E ++L S L+ L+ + + + +L+ + S E + H
Sbjct: 627 EKLLTQMES---EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLH 683
Query: 1609 KELQK---EYEILLQSYENVSNEAE----RIQHVVEAVRQEKQELYGKLRSTEANKKETE 1661
L E E +Y + +AE + Q +E + + +L G++ E +
Sbjct: 684 NVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
Query: 1662 KQLQEAE---QEMEEMKEKMRKFAKSKQQKILELEEENDRLRA-EVHPAGDTAKECMETL 1717
++ + + Q++ E +R KSK ++ E+ L A + PA +
Sbjct: 744 NEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPA---MHHSFANI 800
Query: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777
+ SM E ++E + K L + DSL ++ K Q+ ++ KQ
Sbjct: 801 IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQK-QMNSDLQKQCEELVQI 859
Query: 1778 KHDNQTNV--TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS-HDE 1834
K + + N+ E+ QS ET ++ S V SA K+ +D+
Sbjct: 860 KGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDK 919
Query: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
+ +I +LK+ LE+ ++ + S+TL EK + S IS E++ L +E +
Sbjct: 920 VETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL 979
Query: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEER--------------LMNQLAELNGSIGNY 1940
+N + +E + + E+ D+ E+ L+ + E + +
Sbjct: 980 KEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDL 1039
Query: 1941 CQDVTDAQIKNELLE--------------SEMKNLKKCVSE-----------LEEEKQQL 1975
Q AQ KN LE +E++ LK+ ++ EE Q L
Sbjct: 1040 SQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL 1099
Query: 1976 VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKI 2035
+ E V+ +R E + ++ E G K+ LKE+Q ++++ D ++ E++
Sbjct: 1100 MLELETVQQALRSEMTDNQNNSKSEAGG---LKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
Query: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVL 2095
+ +T + +++E ++ KE ++ + K Q +L ++ LD ++ ++
Sbjct: 1157 MKVMKTKHECQNLESEPIRNS--VKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLE 1214
Query: 2096 A--DNLKLK-KELQSNKESVKSQMKQKDEDLER-RLEQAEEKHLKEKKNMQ--------- 2142
A N +LK +E + KE ++ +++ DLE L+ + + + K+ +
Sbjct: 1215 AMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS 1274
Query: 2143 --EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
+L + + HL+ ++ Q T+NK + E++++ E L + +L ++ L D
Sbjct: 1275 GPHELSTSQNDNAHLQCSL---QTTMNKLN-ELEKICEILQAEKYEL------VTELNDS 1324
Query: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL-------------------- 2240
R I RK ++ + E+++ D+ +L +L
Sbjct: 1325 RSECITAT----RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVS 1380
Query: 2241 -----------------RQMSIHMEELKINISRLE------HDKQIWESKAQTEVQLQQK 2277
+++ +H EL+ L+ HD+ S +E+Q
Sbjct: 1381 LAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTY-- 1438
Query: 2278 VCDTLQGEN---------------KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT 2322
D+L+ EN KE+ LEE L S + S L SL D
Sbjct: 1439 -VDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEG--LVPSLSSSCVPDSSSLSSLGD--- 1492
Query: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE- 2381
S+ EQ G++ ++ E + ++ S +++ LT + K
Sbjct: 1493 --SSFYRALLEQTGDMS-LLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGV 1549
Query: 2382 QKIISLLSGKEEAIQVAIAELRQQ---HDKEIKELENLLSQEEEE--------------- 2423
+++ SL ++++ ++ Q +KEI+ELE LLS E +E
Sbjct: 1550 EELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQW 1609
Query: 2424 -----NIVLEEENKKAVDK--TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
++ LE E+K A +K T QL L+ + Q LD +S+ + + D I
Sbjct: 1610 QQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL----QLQGLDLSSRSLLGIDTE-DAI 1664
Query: 2477 VGDYQQ--LEERHLSIILEKD------QLIQEAAAENNKL-------------------- 2508
G + + + H S E+ Q+ + A ++ L
Sbjct: 1665 QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGE 1724
Query: 2509 -----------KEEIRGLRSHMDDLN--SENAKLDAELIQYREDLNQV-ITIKDSQQKQL 2554
+++ +G + +L+ NA + + + +ED++ + + +K++ + L
Sbjct: 1725 QSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENL 1784
Query: 2555 ------------LEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK 2602
+E L + KEL++K E +L EA +L + L++E DLS+
Sbjct: 1785 RLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSE 1844
Query: 2603 EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL 2662
++E +L ++V + + HA +E+ ++ + S ++R ++E EL
Sbjct: 1845 KLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENEL 1904
Query: 2663 VCVQKEAA-----------------------KKVGEIEDK----LKKELKHLHHDAGIMR 2695
++ E A +K E + K L++EL + + +R
Sbjct: 1905 SRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLR 1964
Query: 2696 NETETAEERVAELARDLVEMEQK--------------LLMVTKENKGLTAQIQSFGRSMS 2741
E +T ++ L + +M++K + + E K T +Q+ +S
Sbjct: 1965 GELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024
Query: 2742 SLQNSRDHANEELDELKRKYDASLKELAQLKEQ-GLLNRERDALLSETAF---SMNSTEE 2797
L + H E+L L++ A +L+ Q LN+E++ L+ E+ ++ ++
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 2798 NSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQ--------------- 2842
L+ + L L+ K E L LSS E+ + + K ++
Sbjct: 2085 EKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKE 2144
Query: 2843 --NERDHLWNELEKFRK----SEEGKQRSAAQPSTSPAEVQSLKKAMS------------ 2884
E D L +++E + SEE ++ S AEV++LK +
Sbjct: 2145 RERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELD 2204
Query: 2885 --SLQNDRDRLLKELKNLQQQYLQINQEITELHPL-----KAQLQEYQDKTKAFQIMQEE 2937
+L+++++ L K+++ Q Q ++++ ++ L +A++Q ++ A +++Q +
Sbjct: 2205 LVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQ 2264
Query: 2938 LRQEN-----LSWQHEL---------------HQLRMEKSSWEIHERRMKEQYLMAISDK 2977
L++ N L E+ HQLR +++ L +
Sbjct: 2265 LKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQL 2324
Query: 2978 DQQLSH-------LQNLIRELRSSSSQTQ--PLKVQYQRQASPETSASPDGSQNLVYETE 3028
+ H ++NL REL + + + L+ + + A +G + E
Sbjct: 2325 KESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLE 2384
Query: 3029 L----LRTQLNDSLKEIHQKELRIQQL---NSNFSQLLEEKNTLSIQLCDTSQSLREN-Q 3080
L +R++ + E+ +++ RI +L NS+F +L+EK +Q+ + S + E Q
Sbjct: 2385 LDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444
Query: 3081 QHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQ 3140
+L A L + +A N+ + E + + + L E + ++ Q
Sbjct: 2445 TQLKELNERVAALHNDQEACKAKEQNL----SSQVECLELEKAQLLQGLDEAKNNYIVLQ 2500
Query: 3141 QQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRL-----EHSEWDSSRTPIIG 3195
+ QEV + ++ LE++ ++ +N + E+ + +L EH W +
Sbjct: 2501 SSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRN 2560
Query: 3196 SCGTQEQALLIDLTSNS 3212
EQ + + + N+
Sbjct: 2561 LTVELEQKIQVLQSKNA 2577
Score = 124 bits (312), Expect = 1e-27
Identities = 225/1088 (20%), Positives = 452/1088 (41%), Gaps = 119/1088 (10%)
Query: 2123 LERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDS 2182
LE E + L++ + ++ +LD L++EK + + ++ L K+ ++V EN +
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKV----ENEKT 60
Query: 2183 TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ 2242
T L + + + + +K ++K S +Q KE ++ +E + K Q+ +
Sbjct: 61 EGTNLKRENQRLM-------EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK 113
Query: 2243 MSIHMEELKINISRLEHDKQIWESK--AQTEVQLQQKVCDT-LQGENKELLSQLEETRHL 2299
+ +ELK S LE +Q +S + QK+ T L S+ E+ +
Sbjct: 114 LE---QELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK 170
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQL 2359
Y+ E +LE+E+K+L Q S +L + N I R Q + +S FS++Q
Sbjct: 171 YNKEVEERKRLEAEVKAL--QAKKASQTLPQATM---NHRDIARHQAS---SSVFSWQQE 222
Query: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ 2419
+T S + ++ S SG++E + D +N S
Sbjct: 223 KTPSHLSSN-----SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSP 277
Query: 2420 EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGD 2479
+ L+ +N++ +K N+L L+ +KE K Q++ F + L+ + ++
Sbjct: 278 HLLDQ--LKAQNQELRNKINELELRLQGHEKE---MKGQVNKFQELQLQLEKAKVELIEK 332
Query: 2480 YQQLEERHLSII---LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536
+ L + ++ + DQ + A KLK+ L + S L+ ++ +
Sbjct: 333 EKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK 392
Query: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
++ + ++ + + Q L+ + Q K A+L ++L++++ + L+ + L
Sbjct: 393 EKEFQEELS-RQQRSFQTLDQECIQMK------ARLTQELQQAKNMHNVLQAELDKLTSV 445
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIA 2656
KQ L +E K +L R A Q ++KE E+ R S + +
Sbjct: 446 KQQLENNLEEFK---QKLCRAEQAFQAS----------QIKENELRR-------SMEEMK 485
Query: 2657 ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEM- 2715
+ L ++ A++V +E +L K +K + + E + + RDL E
Sbjct: 486 KENNLLKSHSEQKAREVCHLEAEL-KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKI 544
Query: 2716 -EQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+Q+ + ++ K A ++ L R+H E+L++ K + K L E
Sbjct: 545 NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE- 603
Query: 2775 GLLNRERDALLSE-TAFS-MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ 2832
L +E + L E T FS S E L+ +E + L SK + HL + L+ +
Sbjct: 604 -LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK---INHLETCLKTQQIKSH 659
Query: 2833 SFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRD- 2891
+++ + +L+ +R++L E+ + K EV++ K A LQ +
Sbjct: 660 EYNERVRTLEMDRENLSVEIRNLHNVLDSKS----------VEVETQKLAYMELQQKAEF 709
Query: 2892 ---RLLKELKNLQQQYLQINQEITEL-HPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH 2947
+ KE++N+ + Q+ ++ +L H L+ E DK + +Q +L E S +
Sbjct: 710 SDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQ----DLHAEYESLRD 765
Query: 2948 ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR 3007
L + E H+R L+A + N+I E S S+ +++ +
Sbjct: 766 LLKSKDASLVTNEDHQRS-----LLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSI 3067
SP+ SA + + + + Q+N L++ Q E +Q L++ +
Sbjct: 821 --SPKNSAILQNRVDSLEFSLESQKQMNSDLQK--QCEELVQIKGEIEENLMKAEQMHQS 876
Query: 3068 QLCDTSQSLRENQQ----HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNGVHR 3122
+ +TSQ + + Q+ H + + LE + +ELQ ++ QE K H
Sbjct: 877 FVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHL 936
Query: 3123 KSDP-EELREPQQSFSEAQQQLCN----TRQEVNELRKLLEEERDQRVAAENALSVAEEQ 3177
D +EL+ ++ S ++++ + ++E+ EL ++ E S+ +E+
Sbjct: 937 LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEEL------TQENGTLKEINASLNQEK 990
Query: 3178 IRRLEHSE 3185
+ ++ SE
Sbjct: 991 MNLIQKSE 998
Score = 51.2 bits (121), Expect = 2e-05
Identities = 65/282 (23%), Positives = 120/282 (42%), Gaps = 54/282 (19%)
Query: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS 106
+ ++Q + Q EL++ + + +L + + L EE K++ +++K+L L S
Sbjct: 2618 ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 107 LNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE----------EMEIEKIKHKLQEK 156
L+ ++ + G V E +E QL H+ + E+EI+ + KL K
Sbjct: 2678 LDCMHKDQVEKEGKV--REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSK 2735
Query: 157 EELIST--LQAQLTQAQAEQPAQS------------STEMEEFVMMKQ------------ 190
EE +S+ L+ L ++ E+ S T+M+ + Q
Sbjct: 2736 EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKM 2795
Query: 191 --------QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFE---TQVRLHEDELLQ 239
QL+E++E LQ +LSQ QA Q Q+ D + + T+++ ++ L +
Sbjct: 2796 KLLIKSCKQLEEEKEI---LQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE 2852
Query: 240 LVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQE 281
+AD + L + KLE+ +E L QV L Q+
Sbjct: 2853 KTKEADEYLDKYCSLLISHEKLEKAKEML--ETQVAHLCSQQ 2892
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 306 bits (785), Expect = 2e-82
Identities = 629/3085 (20%), Positives = 1250/3085 (40%), Gaps = 464/3085 (15%)
Query: 64 LKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK-------------- 109
++D RQK ++ + A +RKA + K K + TS +K
Sbjct: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
Query: 110 -----YIEEMKAQGGTVLPTEP-----QSEEQLSKHDKSSTEEEMEIEKIKHKLQEK--- 156
YI + TV+P S E S S E E EI +
Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
Query: 157 ----------EELISTLQAQLTQAQAEQPAQSS-TEMEEFVMMKQQLQEKEEFISTLQAQ 205
L+ + + + +EQ AQ S T +E MM+ +L K+ I L +
Sbjct: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE---MMESELAGKQHEIEELNRE 177
Query: 206 LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265
L + + + + + ++ FE ++ + + QL LQ+ E +
Sbjct: 178 LEEMRVTYGTEGLQQLQE--FEAAIKQRDGIITQLTAN-------------LQQARREKD 222
Query: 266 ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK--ILLEK 323
E++ + L ELT Q+ QI QQLQ E N+ ++ + ++K IL +
Sbjct: 223 ETMR------EFL--ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 324 MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
+LE + L + ++E + F Q E+E + +E +K E++EK + I
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEEIQEKETIIEE 333
Query: 384 LQKTGQELQSACDALKDQ---NSKLLQDKNEQAVQSAQTIQQLEDQL-------QQKSKE 433
L E + LKD+ KLL + EQ VQ Q I+ ++ +L +Q S+E
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
I Q + + Q + F + + T+ + L+ + E+ ++ + +
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL- 452
Query: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
+ + A+ E++ ++ + A R S I++ + K + A L++T S
Sbjct: 453 IRQHMAQMEEMKTR-----HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
Query: 554 QKHK---ELSVLLLE-------MKEAQEEIAFLKLQLQGKRAEEAD--------HEVLDQ 595
QK K EL ++L E +++ EE++F + Q+Q R A+ H+ L
Sbjct: 508 QKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST 567
Query: 596 KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLN 655
E + E + + ++ L+ + + N + L +EKE+ + + S+E L
Sbjct: 568 VEDLKAEIVSASESRKELELKHEAE----VTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 656 DAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI-LELELNFHKAQE----IYEKN 710
+L + H++EL +LK + +E +N K ++ Y++
Sbjct: 624 RLRTQLLFS-----------------HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ 666
Query: 711 LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLE 770
+D E+S Q IE + DN L +++QL+ ++ +L + + K E
Sbjct: 667 IDGLQNEMS---QKIETMQFEKDN-------LITKQNQLILEISKLKDLQQSLVNSKSEE 716
Query: 771 MNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ 829
M L E Q+ ++ Q + L +++ L ++ + + +++ +N+L + Q +
Sbjct: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776
Query: 830 STLIRSLQSQLQN--KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKR 887
+++++ + L++ K + ER+ + S + ++ +KE+EI L+E+
Sbjct: 777 NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------LIEENE 830
Query: 888 DVETLQQTIEEKDQ-QVTEISFSMTEKMVQLN----EEKFSLGVEIK------TLKEQLN 936
D++ QQ I+ ++ + +FS EK ++N +E+++ +++K K++L
Sbjct: 831 DLK--QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELE 888
Query: 937 LLSRAEEAKKE-QVEEDNEVSSGLKQN-YD----------EMSPAGQISKEELQHEFDLL 984
S+ + +E ++ N + +K + +D EM + EL + ++
Sbjct: 889 YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVT 948
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
K+E + ++L K+ +S L EE+ +LK E K+++ L E E+ +
Sbjct: 949 KREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE-KEQVSLRCREL-EIIINHNRA 1006
Query: 1045 EYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD--------LEEKLAAEEQFQALVKQ 1096
E + C T ++ + T E + + K +E+K++ E +
Sbjct: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Query: 1097 MNQTLQDK----TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE------TVV 1146
Q + D T + L + SEN + ++L N S+ + + L E ++V
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKEL---NVLKSEQNDLRLQMEAQRICLSLV 1123
Query: 1147 ISPPCTGSSEHWKPE--------LEEKILALEKEKEQLQKKLQEALTSRKA--------- 1189
S E+ + E EE I A E++ ++LQK Q L + K
Sbjct: 1124 YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKP 1183
Query: 1190 -------ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRE 1242
+ K E+ + + L +Y + + +++ EN GD + + + E
Sbjct: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP--E 1241
Query: 1243 SIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG- 1301
D + D QE+ + L K TE+++ VL++ L W D L+ G
Sbjct: 1242 LQDYRYEVQDFQEN------MHTLLNKVTEEYNKLLVLQTRLSKIW-GQQTDGMKLEFGE 1294
Query: 1302 -------TSVAQIKAQLKEIEAEKVELELKVSSTTS-ELTKKSEEVFQLQEQINKQGLEI 1353
T I +Q+ +E V + K+SS E TK E+V +L+ I+ ++
Sbjct: 1295 ENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQL 1354
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG 1413
+ + ++EAE+H LQ++L++ + P L +I++ + + G
Sbjct: 1355 KETEQ-NYEAEIHC--LQKRLQAVSES--------TVPPSLPVDSVVITESDAQRTMYPG 1403
Query: 1414 QLSEKEAALT---KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470
+K T + + E+ +++K L Q + Q +E + ++ V + + E
Sbjct: 1404 SCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL---EEEVAKVIVSMSIAFAQQTE 1460
Query: 1471 IGEESRAKQQIQRKLQAALISRKEA--LKENKSLQEELSLA---------RGTIERLTKS 1519
+ S K+ QA + ++E E K Q+++ + + L+K
Sbjct: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE 1520
Query: 1520 LADVESQVSAQNKE-------KDTVLGRLALLQEE---RDKLITEMDRSLLENQSLSSSC 1569
L + ++ N + KD VL + EE +DK + +S+ + S+SS
Sbjct: 1521 LGEHGKEILLSNSDPHDIPESKDCVL----TISEEMFSKDKTFI-VRQSIHDEISVSSMD 1575
Query: 1570 ESLKLAL--EGLTEDKEKLVKE-------IESLKSSKIAESTEWQEKHKELQKEYEIL-- 1618
S +L L E L + +++LV++ E L+ + + + +E ++LQ+E + L
Sbjct: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
Query: 1619 -LQSYENVSNE---AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674
L ++ NE +ER + ++E + KQ + + Q Q + E+
Sbjct: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695
Query: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME 1734
+E+ K E+E DR +V P + E ++N +K LE VK
Sbjct: 1696 EEQTFK------------EKELDRKPEDV-PPEILSNERYALQKANNRLLKILLEVVKTT 1742
Query: 1735 ---YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
ET+ + ++ ++ S S+ L + E S ++ + H+ T VT+E
Sbjct: 1743 AAVEETIGRHVLGIL-DRSSKSQSSASLIWRSEAEASVKSCV-----HEEHTRVTDESIP 1796
Query: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851
S G ++ ++M ++ T +E Q++ ++ AG
Sbjct: 1797 SYSGSDMPRNDINMWSKVT----------------------EEGTELSQRL--VRSGFAG 1832
Query: 1852 LE---EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908
E E ++ S L+ LL IS +L+ +VT+ L+ + +++
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE--HAKVTQTELMRESFRQKQEAT 1890
Query: 1909 TKLKETAE-----EEKDDLEERLMNQLAELNGSIGNYCQDVT--DAQIKN-----ELLES 1956
LK E E+ E+L +L++ G I Y + T + QI+ + LE
Sbjct: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950
Query: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
E+ + ELE E+QQ+ +E+ + + KE ++ A+ P + +E ++L+KE
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQ--KEAMK----AEAGPVEQQLLQETEKLMKE 2004
Query: 2017 KQQEVKQLQKDCIRYQEKISALERTV--KALEFVQTESQK-----DLEITKENLAQAVEH 2069
K + Q +K Q+++ ALE V + F++ E +K DL + L + +E
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
Query: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
+K E A + D + + L LK+ Q E +++Q L+ + ++
Sbjct: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDK 2124
Query: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189
E L K+ +Q + E LE + E++ L Q++++ +
Sbjct: 2125 CSEL-LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKP 2183
Query: 2190 FTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEE 2249
LQ +RD ID +K + ++ EE+ K + L Q+ I +E
Sbjct: 2184 ELSLEVQLQAERD-AIDRKEKEITNLEEQLEQFREELENKNEEVQQLH---MQLEIQKKE 2239
Query: 2250 LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL----SQLEETRHLYHSSQN 2305
+ LE + ++++ + ++ L K D + +++ +L +Q+ + + + N
Sbjct: 2240 STTRLQELEQENKLFKDDME-KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
Query: 2306 E-LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364
E + KL+ +LK D + E ++ + +E ++ QE +N + EQL ++
Sbjct: 2299 EQVTKLQQQLKITTDNKV-IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2357
Query: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424
++ + + ++ +M + + + V IAE LE + EE
Sbjct: 2358 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK--------LALEQQVETANEEM 2409
Query: 2425 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
++ K+ K NQL + L ++K+E V+ + S+ + + D+ +
Sbjct: 2410 TFMKNVLKETNFKMNQLTQELFSLKRER--------ESVEKIQSIPENSVNVAIDHLSKD 2461
Query: 2485 ERHLSIILEKD-------QLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ-Y 2536
+ L ++L +D Q ++ EN K I L + + L S + D EL Q Y
Sbjct: 2462 KPELEVVLTEDALKSLENQTYFKSFEENG--KGSIINLETRLLQLESTVSAKDLELTQCY 2519
Query: 2537 REDLNQVITIKDSQQKQLLEVQLQQNK----------------------ELENKYAKL-E 2573
++ IKD Q++ E ++ Q K E +YAK +
Sbjct: 2520 KQ-------IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ 2572
Query: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633
+ S E ++ N L+E+ +L +I +L + IS+L QV + H
Sbjct: 2573 DNQTISSEPERTNIQNLNQLRED--ELGSDISALTLRISELESQVVEM---------HTS 2621
Query: 2634 LKVKEEEVHRLSALFSSSQKRIAELEE-----ELVCVQKEAAKKVGEIED-KLKKELKHL 2687
L +++E+V +K++ EL++ E +KE + ++E K EL H
Sbjct: 2622 LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS 2681
Query: 2688 HHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSR 2747
+ ++G NE E +L ++K + +E + S + +S +++
Sbjct: 2682 NEESGFF-NELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL 2740
Query: 2748 DHANEELDELKRKYDASLKELAQ-LKEQGLLNRERDALLSETAFSMNSTEENSLSHL--- 2803
A E+L L+++ + ++E + + L + ++ S+T ++ + N +
Sbjct: 2741 AEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVK 2800
Query: 2804 ---EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEE 2860
++N Q E++ + SQ + ++Q A L E H+ R+
Sbjct: 2801 NAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL-HAAEILDMESRHISETETLKREHYV 2859
Query: 2861 GKQRSAAQPSTSPAEVQSLKKAMSS 2885
Q + T A +Q L+ S
Sbjct: 2860 AVQLLKEECGTLKAVIQCLRSKEGS 2884
Score = 299 bits (765), Expect = 3e-80
Identities = 689/3378 (20%), Positives = 1409/3378 (41%), Gaps = 546/3378 (16%)
Query: 8 LANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQ-EDVQERLAYAEQLVVELKD 66
L NV ++EL+ + + L EL + + Q ED+ E L+++ + + +
Sbjct: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549
Query: 67 IIRQKDVQLQQKDEALQ--EERKA----ADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120
I +++ +L + ++L E+ KA A K+L+L +A++T+ +E ++ +
Sbjct: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609
Query: 121 VLPTEPQSEEQ---------LSKHDK--SSTEEEMEIEKIKHKLQEKEELISTLQAQLTQ 169
VL +S+E L H++ S +E++EIE + + K+ L + Q+
Sbjct: 610 VLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG 669
Query: 170 AQAEQPAQSST---EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226
Q E + T E + + + QL + + LQ L +++E+ Q+ + +
Sbjct: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI---NELQK 726
Query: 227 ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE 286
E ++ L ++E + + +V+ E+Q K +L+++++E E L Q++ E
Sbjct: 727 EIEI-LRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKENDL----------QEKFAQLE 774
Query: 287 QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE----VAERKLSF-----HN 337
N IL + + +E + L+ +EE I L+ ++ + V E+++ +
Sbjct: 775 AENSILKDEKKTLE---DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 338 LQEEMHHLLEQFEQAGQ----AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS 393
L+++ L E+ E+ A+ E Y L++++ ++ K S K E +S
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKS 891
Query: 394 ACDALKDQ------NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
AL ++ N ++ K+ + + + + + K+ ++ + +L + + E
Sbjct: 892 KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951
Query: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL----KAEN-E 502
+ +E + E I+ L + V L+ EK + L ELE + +AEN +
Sbjct: 952 KLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010
Query: 503 KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN-TFSQKHKELSV 561
+Q++ L T + +S V+ + S + EN T ++ K+ +
Sbjct: 1011 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL 1070
Query: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL--DQKEMK-QMEGEGIAPIKMKVFLEDT 618
+L + +E + Q + + VL +Q +++ QME + I V+
Sbjct: 1071 ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC--LSLVYSTHV 1128
Query: 619 GQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678
Q M NE+ KE+ + + E ++ ++ T++ GD+ I
Sbjct: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Query: 679 GQCHQDELERLK--------------SQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 724
G+ + E + L+ E+N + + + + E+ +
Sbjct: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248
Query: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784
+++F++N + ++EE ++LL LS + + +LE E + +
Sbjct: 1249 VQDFQENMH---TLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---EENLPKEET 1302
Query: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844
E + H + + + + KSK ++ L+ + Q+Q E +LI SLQ QL KE
Sbjct: 1303 EFLSIHSQMTN--LEDIDVNHKSKLSSLQDLEKTKLEEQVQ--ELESLISSLQQQL--KE 1356
Query: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904
+E AE + + +++ +S++ L + + I E D Q T
Sbjct: 1357 TEQNYEAE-IHCLQKRLQAVSESTVPPSLPVDSV----------------VITESDAQRT 1399
Query: 905 EISFSMTEKMVQLNEEKFS--LGVEIKTLKEQLNLLSRAEEAKKEQVEED---------- 952
S +K + E FS GV KE+ N++ E+ +EQ+EE+
Sbjct: 1400 MYPGSCVKKNIDGTIE-FSGEFGV-----KEETNIVKLLEKQYQEQLEEEVAKVIVSMSI 1453
Query: 953 -----NEVS--SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK-RKLQAALINRKE 1004
E+S SG K+N A + ++E QH F+ +K +Q + + + KE
Sbjct: 1454 AFAQQTELSRISGGKENTASSKQAHAVCQQE-QHYFNEMKLSQDQIGFQTFETVDVKFKE 1512
Query: 1005 LLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEI-----E 1059
+ +S+ EL E KEI LS ++ ++ E K+ CV + +E+
Sbjct: 1513 EFKPLSK---ELG----EHGKEILLSNSDPHDIPESKD-------CVLTISEEMFSKDKT 1558
Query: 1060 IYLKQTISEK---------------EVELQHIRKDLEEKLAAEEQFQALVKQ--MNQTLQ 1102
++Q+I ++ E +L+ +R++L + +Q L++Q M Q +
Sbjct: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
Query: 1103 DKTNQIDLLQAEISE-NQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPE 1161
+ +Q + LQ EI N+ + Q+ N + L++E + E E
Sbjct: 1619 QREDQ-EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677
Query: 1162 LEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL--REELKQQKDDYNRLQEQF 1219
L + E Q +++E K + +K ++ + E QK + NRL +
Sbjct: 1678 LRNSSTQTQNGNEN-QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN-NRLLKIL 1735
Query: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST---PGLEEPLFKATEQHHT 1276
E K + + + + + G L + + +S +S E + + HT
Sbjct: 1736 LEVVKTTAAVEETIGR-------HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788
Query: 1277 QPVLESNLC---PDWPSHSED--ASALQGGTSVAQIKAQL----KEIEAEKVELELKVSS 1327
+ ES D P + + + + GT ++Q + EI+ E EL L +SS
Sbjct: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848
Query: 1328 TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHL 1387
+K L E I++ ++E K + E+ ES +QK E+++ L+
Sbjct: 1849 RLQAAVEK------LLEAISETSSQLEHAKVT--QTELMRESFRQKQEATE----SLKCQ 1896
Query: 1388 RELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQA 1447
EL+ +L E + + ++S G + T + +I E+ D+I L +L +
Sbjct: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956
Query: 1448 KEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEAL-KENKSLQEEL 1506
R+++L+ E +++++ E + + A + ++ L+ E L KE +Q +
Sbjct: 1957 N----RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012
Query: 1507 SLARGTIERLTKSLA-DVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565
R +++ K+L DVE QVS R L++E++ TE+ +NQ+L
Sbjct: 2013 EKVRDDLQKQVKALEIDVEEQVS-----------RFIELEQEKN---TELMDLRQQNQAL 2058
Query: 1566 SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENV 1625
E ++ L+ D+E E +Q++ ++L+++ +++ + ++ +
Sbjct: 2059 EKQLEKMRKFLDEQAIDREH--------------ERDVFQQEIQKLEQQLKVVPR-FQPI 2103
Query: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK 1685
S R VE + +E K +K++ ++ +QE +E+E+++ ++R+
Sbjct: 2104 SEHQTR---EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL---- 2156
Query: 1686 QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745
+Q +L + ++ H AK + + A ++ ++R + E L ++ +
Sbjct: 2157 EQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE-RDAIDRKEKEITNLEEQLEQF 2215
Query: 1746 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805
E ++ +EEVQ L Q+E + K+ + ++ + + + ++ + + +E D++S
Sbjct: 2216 REELENKNEEVQQLHMQLE--IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS- 2272
Query: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865
T + V K A K+ +IDQL E++ L+++ + + ++
Sbjct: 2273 ----TQDQHVLFGKFAQIIQEKEV-----------EIDQLNEQVTKLQQQLKITTD-NKV 2316
Query: 1866 LENEKNTLLSQISTK------DGEL--KMLQEEVTKMNLLNQQIQEELSRVTKLKE---- 1913
+E EKN L+ + T+ D E + +EE+ ++N + +++Q+EL+ + +
Sbjct: 2317 IE-EKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH 2375
Query: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
+ EE D L+ +L +AE + + Q+ E EM +K + E +
Sbjct: 2376 SLSEEADSLKHQLDVVIAE---------KLALEQQV--ETANEEMTFMKNVLKETNFKMN 2424
Query: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGN------KSHAKELQELLKE-------KQQE 2020
QL +E ++ E +E +EKIQ + N EL+ +L E Q
Sbjct: 2425 QLTQELFSLKRE--RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2482
Query: 2021 VKQLQKD----CIRYQEKISALERTVKALEFVQTESQKDLEITKE--------------N 2062
K +++ I + ++ LE TV A + T+ K ++ +E N
Sbjct: 2483 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVN 2542
Query: 2063 LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD-- 2120
L + VE +K A L S ++ L+ Q E A+ DN + E + +Q+++ +
Sbjct: 2543 LQKIVE--EKVAAALVS-QIQLEAVQ-EYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2598
Query: 2121 ---EDLERRLEQAEEKHLKEKKNM---QEKLDALRREKVHLEETIGEIQVTLN---KKDK 2171
L R+ + E + ++ ++ +E+++ + + E+ + E+Q L KK +
Sbjct: 2599 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2658
Query: 2172 EVQQLQENLD----STVTQL------AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS 2221
E ++ + D T T+L + F + +L+ + E ++ K +
Sbjct: 2659 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEK----AEK 2714
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC-- 2279
+EE+ +KE N + L+ L Q+ H+ E K +S LE + + TEVQ +K C
Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE-------TEVQESKKACMF 2767
Query: 2280 DTLQGE-NKELLSQLEETRHLYHSSQNE--LAK-------LESELKS--LKDQLTDLSNS 2327
+ L + +K + SQ + T + S+Q L K L+SE S + + ++ +
Sbjct: 2768 EPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEK 2827
Query: 2328 LEKCKEQKG------------NLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHE 2375
+EK +E E + R+ +Q K L+ +Q R
Sbjct: 2828 IEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIP 2887
Query: 2376 EINMKE----QKIISLLSGKE----------EAIQVAIAELRQQHD-------KEIKELE 2414
E+ + ++I S SG + + +A ++ + K+IK L
Sbjct: 2888 ELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLL 2947
Query: 2415 NLLSQEEEENIVLEE-------------------ENKKAVDKTNQLMETLKTIKKENIQQ 2455
+ E + + L E E +KA T ++ L I K +Q+
Sbjct: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL--ITKMQLQR 3005
Query: 2456 KAQLDSFVKSMSSLQNDRDRIVGDYQQ--LEERHLSIILEKDQLIQEAAAE--------N 2505
+A++ +S S + R ++ QQ LEER + + + +L +
Sbjct: 3006 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLE 3065
Query: 2506 NKLKEEIRGLRSHMDDLN-SENAKLDAELIQYREDLN-QVITIKDSQQ-----KQLLEVQ 2558
+++E+ ++ M+ L ++ L +E+ +N + IT+K Q+ ++LLE
Sbjct: 3066 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 3125
Query: 2559 LQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI-SQLTRQ 2617
+QQ +++ +++ +L ++ +L+ ++ + +L E+ K+ + + L Q
Sbjct: 3126 IQQK---QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3182
Query: 2618 VTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE 2677
L+E L + ++K K +EVH L+ +S QK+ EL+ L +KE AK +G E
Sbjct: 3183 HKHLKE---LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL---EKEKAK-LGRSE 3235
Query: 2678 DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737
++ K+EL+ L + E+ ++R +L +L+ +QK L+ + K + +Q +
Sbjct: 3236 ERDKEELEDL-------KFSLESQKQRNLQL--NLLLEQQKQLLNESQQK-IESQRMLYD 3285
Query: 2738 RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEE 2797
+S Q N EL L ++E++ L+RER+ L S + T +
Sbjct: 3286 AQLSEEQGR----NLELQVLLESEKVRIREMSST-----LDRERE--LHAQLQSSDGTGQ 3334
Query: 2798 NSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR- 2856
+ + L ++ L L QLE+ ++++ L NE EK++
Sbjct: 3335 S---------RPPLPSEDLLKELQKQLEEKHSRIVE--------------LLNETEKYKL 3371
Query: 2857 KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHP 2916
S + +Q+ +Q+ ++A + Q L ++++LQ+Q + Q++ +
Sbjct: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV---YK 3428
Query: 2917 LKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISD 2976
L + Q Q + FQ QE R+E + L+Q E ++W + R + L +
Sbjct: 3429 LDLEGQRLQGIMQEFQ-KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3487
Query: 2977 KDQQLSHLQNLI-----------------RELRSSSSQTQPLKVQYQRQASPETSASPD- 3018
+ + S+ LI ++L+ +S+ Q L + + ET+ D
Sbjct: 3488 GETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDF 3547
Query: 3019 -----GSQNLVYETELLRTQLND---------SLKEIHQKELRIQ-QLNSNFSQLLEEKN 3063
++ + + L Q + S + ++ LR +L + SQL EEKN
Sbjct: 3548 IWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKN 3607
Query: 3064 TLSIQLCDTSQSLRENQQ 3081
L + + +R +Q
Sbjct: 3608 DLRNMVMKLEEQIRWYRQ 3625
Score = 286 bits (731), Expect = 3e-76
Identities = 722/3545 (20%), Positives = 1404/3545 (39%), Gaps = 636/3545 (17%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKL 96
E D + N+ +E++QE+ E+L ++ ++EE+K
Sbjct: 311 EQDKKVENSNKEEIQEKETIIEELNTKI-----------------IEEEKKT-------- 345
Query: 97 KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK 156
L K KLT+ +K + E+ +EQ+ + ++ ++E+ K K ++
Sbjct: 346 -LELKDKLTTADKLLGEL--------------QEQIVQKNQEIKNMKLELTNSKQKERQS 390
Query: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
E I L + + Q S E + M+Q+ Q K E + ++ Q Q Q
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
Query: 217 QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVD 276
+++R+ A+ E H+ E+ + T + +++++ + E L +
Sbjct: 451 ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
Query: 277 LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336
L++EL + L +QL+ + E + R ++ R+ I ++ +L A + LS
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKSLS-- 566
Query: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSA--LEQKHKAEMEEKTSHILSLQKTGQELQSA 394
+ L + A +++ ELE ++ A K K EM EK + + L + + ++
Sbjct: 567 ----TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV-LDRMAESQEAE 621
Query: 395 CDALK--------DQNSKLLQD------------KNEQAVQSAQTIQQLEDQLQQKSKEI 434
+ L+ ++ SKL +D K+ + Q I L++++ QK + +
Sbjct: 622 LERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
Query: 435 SQFLNRLPLQQHETASQTS-FPDVYNEGTQAVTEE---NIASLQKRVVEL---ENEKGAL 487
+ L +Q++ + S D+ + +EE I LQK + L E EKG L
Sbjct: 682 QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741
Query: 488 LLSSIELE--------ELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS 539
EL+ ++K + L + LEA+N + +++ E D+ +
Sbjct: 742 EQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE----DMLKIHTPV 797
Query: 540 AEESGQDVLENTFSQK-----HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
++E L++ S+ KE+ +L+ E ++ +++ L +++ +R + E
Sbjct: 798 SQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNF 857
Query: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
+ ++++ E +K+K LED+ L +S L A+ +E H R +
Sbjct: 858 EVNYQELQEEYACLLKVKDDLEDSKNKQEL--EYKSKLKALNEEL----HLQR------I 905
Query: 655 NDAGVELKSTKQDGDKSLSA-VPDIGQCHQ-------DELERLKSQILELELNFHKAQEI 706
N V++KS+ D DK+ A ++G+ + ++LE K + LEL E
Sbjct: 906 NPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE- 964
Query: 707 YEKNLDEKAKEISNLNQLIEEFKK-------------------NADNNSSAFTALSEERD 747
L +K EIS LN+ ++ K+ A+N S T +S D
Sbjct: 965 ---QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
Query: 748 QLLSQVKELSMVTELRAQVKQLEMNLAEAER---QRRLDYESQTAHDNLLTEQI---HSL 801
+++ V ++ + E + + ++ +E+ T + EQ+ H
Sbjct: 1022 GVVTMTSR-----GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLP 1076
Query: 802 SIEAKSK------------DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849
S+ +S ++ VL++E +D++LQ Q + + S ++ E +E
Sbjct: 1077 SVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYME 1136
Query: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS 909
E+ + + S EEL A +K E+ K+ QL L+ + ET + + +
Sbjct: 1137 N-EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET------GDEGKPLHLLIG 1189
Query: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSG--LKQNYDEMS 967
+K V E + L L E A K +V +++ +SG + +N D
Sbjct: 1190 KLQKAVS-EECSYFLQTLCSVLGEYYT------PALKCEVNAEDKENSGDYISENEDPEL 1242
Query: 968 PAGQISKEELQHEF-DLLKKENEQRKRKLQAALINRKELLQRVSRL-EEELANLKDE-SK 1024
+ ++ Q LL K E+ + L L R+S++ ++ +K E +
Sbjct: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLL--------VLQTRLSKIWGQQTDGMKLEFGE 1294
Query: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084
+ +P ETE + N E + SK ++ K + E+ EL+ + L+++L
Sbjct: 1295 ENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQL 1354
Query: 1085 AAEEQ-FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
EQ ++A + + + LQ + ++ + + + +IT + + VK+
Sbjct: 1355 KETEQNYEAEIHCLQKRLQ------AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKK 1408
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEKE-KEQLQKKLQEALTSRKAILKKAQEKERHL- 1201
I S E E + LEK+ +EQL++++ + + S + E R
Sbjct: 1409 N--IDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
Query: 1202 -REELKQQKDDYNRLQEQ---FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257
+E K + Q++ F+E + IG Q E++D K + S
Sbjct: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-------FQTFETVDVKFKEEFKPLSK 1519
Query: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSED--------------ASALQGGTS 1303
+E L ++ H + L S+D S++
Sbjct: 1520 ELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQ 1579
Query: 1304 VAQIKAQLKEIEAEKVE--------LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIES 1355
+ + QL+++ E V EL + ++ ++ E+ QLQE+I + ++
Sbjct: 1580 LMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639
Query: 1356 LKTVSHEAEVHAES--LQQKLES-SQLQIAGLEHL--------------RELQPKLDE-- 1396
++ +E V L ++LE+ QL +AG E L E Q +++E
Sbjct: 1640 RSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT 1699
Query: 1397 -LQKLISKKEEDV--SYLSGQ---LSEKEAALTKIQTEIIE------------------- 1431
+K + +K EDV LS + L + L KI E+++
Sbjct: 1700 FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDR 1759
Query: 1432 ------QEDLIKALHTQLEMQAKEHDERIK-----------------------QLQVELC 1462
LI + +++ H+E + ++ E
Sbjct: 1760 SSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGT 1819
Query: 1463 EMKQKPEEIG--------EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
E+ Q+ G E I +LQAA+ EA+ E S +L A+ T
Sbjct: 1820 ELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSS---QLEHAKVTQT 1876
Query: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM-----------------DR 1557
L + + + + K ++ + RL R++L E+ +R
Sbjct: 1877 ELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936
Query: 1558 SLLENQSLSSSCESLKLA----LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613
+ E + E L L+ L +++++ +E E L K A E ++L +
Sbjct: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
Query: 1614 EYEILLQSYENVSNEAERI----QHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669
E E L++ V +AE++ Q V+A+ + +E + E K L++ Q
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQ 2056
Query: 1670 EMEEMKEKMRKFAKSK-----------QQKILELEEE----------NDRLRAEVHPAGD 1708
+E+ EKMRKF + QQ+I +LE++ ++ EV +
Sbjct: 2057 ALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLAN 2116
Query: 1709 TAKE----CMETLLSSNASMK------EELERVKMEYETLSKKFQSLMSEKDSLSEEVQD 1758
KE C E LLS + EE+E+++ L Q+L+ D+ ++V+D
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE---QALLVSADTF-QKVED 2172
Query: 1759 LKH--------QIEGNVSKQANLEATEKHDNQ-TNVTEEGTQ---SIPGETEEQDSLSMS 1806
KH ++ V QA +A ++ + + TN+ E+ Q + + EE L M
Sbjct: 2173 RKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2232
Query: 1807 TRPTCSES---VPSAKSANPAVSKD-------------FSSHDE----------INNYLQ 1840
ES + + N D S+ D+ I
Sbjct: 2233 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2292
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTK------DGEL--KMLQEEVT 1892
+IDQL E++ L+++ + + ++ +E EKN L+ + T+ D E + +EE+
Sbjct: 2293 EIDQLNEQVTKLQQQLKITTD-NKVIE-EKNELIRDLETQIECLMSDQECVKRNREEEIE 2350
Query: 1893 KMNLLNQQIQEELSRV----TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
++N + +++Q+EL+ + + + EE D L+ +L +AE + + Q
Sbjct: 2351 QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE---------KLALEQQ 2401
Query: 1949 IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK 2008
+ E EM +K + E + QL +E ++ E +E +EKIQ + N +
Sbjct: 2402 V--ETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE--RESVEKIQSIPENSVNVA--- 2454
Query: 2009 ELQELLKEKQQEVKQLQKDCIRYQE------------KISALERTVKALEFVQTESQKDL 2056
+ L K+K + L +D ++ E K S + + L+ T S KDL
Sbjct: 2455 -IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL 2513
Query: 2057 EITK-----------------------ENLAQAVEHRKKAQAELASFKVLLDDTQSEAAR 2093
E+T+ NL + VE +K A L S ++ L+ Q E A+
Sbjct: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE--EKVAAALVS-QIQLEAVQ-EYAK 2569
Query: 2094 VLADNLKLKKELQSNKESVKSQMKQKD-----EDLERRLEQAEEKHLKEKKNM---QEKL 2145
DN + E + +Q+++ + L R+ + E + ++ ++ +E++
Sbjct: 2570 FCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQV 2629
Query: 2146 DALRREKVHLEETIGEIQVTL---NKKDKEVQQLQENLD----STVTQL------AAFTK 2192
+ + + E+ + E+Q L KK +E ++ + D T T+L + F
Sbjct: 2630 EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN 2689
Query: 2193 SMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKI 2252
+ +L+ + E ++ K + +EE+ +KE N + L+ L Q+ H+ E K
Sbjct: 2690 ELEALRAESVATKAELASYKEK----AEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKE 2745
Query: 2253 NISRLEHDKQIWESKAQTEVQLQQKVC--DTLQGE-NKELLSQLEETRHLYHSSQNELAK 2309
+S I E + +TEVQ +K C + L + +K + SQ + T L SS N+ +
Sbjct: 2746 KLS-------ILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGT--LKISSSNQTPQ 2796
Query: 2310 LESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE---ADIQNSKFSYEQLETDLQAS 2366
+ + ++ L +S E + E I + QE A+I + + + L+
Sbjct: 2797 ILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKRE 2856
Query: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN--------LLS 2418
+ +L +E + +I L KE + +A +EI ++ L+
Sbjct: 2857 HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLT 2916
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
+ +I E +++ T+ + +K + + + Q+ S +S S D
Sbjct: 2917 HSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQV 2976
Query: 2479 DYQQLEER--------HLSIILEKDQLIQEAAA-ENNKLKEEIRGLRSHMDDLNSENAKL 2529
LEER L ++ K QL +EA ++++ E R + L + L
Sbjct: 2977 SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGEL-LLALQQVFL 3035
Query: 2530 DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS 2589
+ + ++ + + LL Q+ +E +Y E L++++ RRS
Sbjct: 3036 EERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKAD------RRS 3089
Query: 2590 FNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFS 2649
L E Q L ++ K+++ + QE L ++ K+ ++ + S
Sbjct: 3090 ---LLSEIQALHAQMNGRKITLKREQESEKPSQE-----LLEYNIQQKQSQMLEMQVELS 3141
Query: 2650 SSQKRIAELEEELVC-------VQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAE 2702
S + R EL+E+L ++ E A+ E+E LK + KHL + R E +
Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHL-KELEAFRLEVKDKT 3200
Query: 2703 ERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYD 2762
+ V L D + EQ K+++ L ++ + + L S + EEL++LK
Sbjct: 3201 DEV-HLLNDTLASEQ------KKSRELQWALE---KEKAKLGRSEERDKEELEDLK---- 3246
Query: 2763 ASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSS 2822
L+ Q N + + LL + +N +++ S + QL + + L L
Sbjct: 3247 ------FSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300
Query: 2823 QLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKA 2882
LE +++ S ++L ER EL +S +G + S P + L K
Sbjct: 3301 LLESEKVRIREMS---STLDRER-----ELHAQLQSSDGTGQ-----SRPPLPSEDLLKE 3347
Query: 2883 MSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQEN 2942
+ ++ + EL N ++Y +L L+ + Q +D+ + +Q E ++ N
Sbjct: 3348 LQKQLEEKHSRIVELLNETEKY--------KLDSLQTRQQMEKDRQVHRKTLQTE-QEAN 3398
Query: 2943 LSWQHELHQL--RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS----SS 2996
Q ++H+L ++E ++ E+R + L D + LQ +++E +
Sbjct: 3399 TEGQKKMHELQSKVEDLQRQLEEKRQQVYKL------DLEGQRLQGIMQEFQKQELEREE 3452
Query: 2997 QTQPLKVQYQRQASPET-SASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNF 3055
+ + ++ YQ P T S + D ++N V L+ ++ KE + +L ++N
Sbjct: 3453 KRESRRILYQNLNEPTTWSLTSDRTRNWV-----LQQKIEGETKESNYAKL--IEMNGGG 3505
Query: 3056 SQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQ 3115
+ E + +L + L+ Q + L ++ +Q NID Q
Sbjct: 3506 TGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE---NIDEIILQLQ 3562
Query: 3116 EKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEV-NELRKLLEEERDQRVAAENALSVA 3174
+ G ++ + L P S ++L E+ + +L EE+ D R N +
Sbjct: 3563 KLTG--QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR----NMVMKL 3616
Query: 3175 EEQIR 3179
EEQIR
Sbjct: 3617 EEQIR 3621
Score = 225 bits (574), Expect = 5e-58
Identities = 596/3013 (19%), Positives = 1245/3013 (41%), Gaps = 417/3013 (13%)
Query: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ---LQQKDEALQEERKAA 89
E+ ++ E + +E+L +++L +L + ++QK + L ++ ++L++E++
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
Query: 90 DNKIKKLKL---HAKAK-LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145
+ ++L++ H +A+ + S + + + G V T +E +SK +KS EE
Sbjct: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLL--DGVVTMTSRGAEGSVSKVNKSFGEESKI 1048
Query: 146 IEKIKHKLQ--------EKEELISTLQAQLTQA---QAEQPAQSSTEMEEFVMMKQQLQE 194
+ + K + ++E+LI +T+ +A QP+++ +E ++K + +
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
Query: 195 KEEFISTLQAQLS---QTQAEQAAQQVVREKDARF----ETQVRLHEDEL--LQLVTQAD 245
+ + LS T +Q + + EKD E + E+++ LQ + Q +
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168
Query: 246 VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305
++T Q+ + L L+G+ Q A + Q L + E+ T
Sbjct: 1169 LQTMKTQETGDEGKPLH----LLIGKLQ---------KAVSEECSYFLQTLCSVLGEYYT 1215
Query: 306 --LRNTVETEREESK--ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
L+ V E +E+ + E + E+ + + + QE MH LL + + L++
Sbjct: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQT 1275
Query: 362 RYSAL--EQKHKAEMEEKTSHILSLQKTGQELQSACDALKD----QNSKL--LQD----K 409
R S + +Q ++E ++ + + S L+D SKL LQD K
Sbjct: 1276 RLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK 1335
Query: 410 NEQAVQSAQTI-----QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464
E+ VQ +++ QQL++ Q EI RL + S+++ P +
Sbjct: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL-----QAVSESTVPPSLPVDSVV 1390
Query: 465 VTEENIA-SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
+TE + ++ +N G + S E + E ++ + LLE Q + + + E
Sbjct: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSG----EFGVKEE--TNIVKLLEKQYQE-QLEEE 1443
Query: 524 VSEISI---VDIANKRSSSAEESGQDVLENTFSQKH-----KELSVLLLEMKEAQEEIAF 575
V+++ + + A + S G+ ENT S K ++ EMK +Q++I F
Sbjct: 1444 VAKVIVSMSIAFAQQTELSRISGGK---ENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
Query: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635
+ + +E E K + E L + G++ L ++ +P
Sbjct: 1501 QTFETVDVKFKE---------EFKPLSKE----------LGEHGKEILLSNSDPHDIPE- 1540
Query: 636 EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC--HQDELERLKSQI 693
S + SEE+ D ++ + D + S+S++ Q ++++LE ++ ++
Sbjct: 1541 -----SKDCVLTISEEMFSKDKTFIVRQSIHD-EISVSSMDASRQLMLNEEQLEDMRQEL 1594
Query: 694 LELELNFHKAQEIYEK-NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752
+ +A E+ + ++ + ++ + QL EE K+ N S + + L+S+
Sbjct: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL---NRQLAQRSSIDNENLVSE 1651
Query: 753 VKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYESQTAHDN---LLTEQIHSLSIEA 805
+E ++ EL A +KQL +LA E+ R ++Q ++N + + ++
Sbjct: 1652 -RERVLLEELEA-LKQL--SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707
Query: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
K +DV E+L NE +Q + ++ + E + + SSK + +
Sbjct: 1708 KPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSA 1767
Query: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISF--SMTEKMVQLNEEKFS 923
+ + E E + + E R + + D +I+ +TE+ +L++
Sbjct: 1768 SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR 1827
Query: 924 ---LGVEIKTLKEQL--NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
G EI E+L N+ SR + A ++ +E +E SS L+ + + S + Q
Sbjct: 1828 SGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
Query: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
+ LK + E R+R L R++L +S+ E + DE L E + E
Sbjct: 1888 EATESLKCQEELRER-LHEESRAREQLAVELSKAEGVIDGYADEKT----LFERQIQEKT 1942
Query: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ--FQALVKQ 1096
+ + E C +++ QE+E +Q E+E+ L ++ ++ + EQ Q K
Sbjct: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEEREL-LSRQKEAMKAEAGPVEQQLLQETEKL 2001
Query: 1097 MNQTLQ----------DKTNQIDLLQAEISENQA-IIQKLITSNTDASD--GDSVALVKE 1143
M + L+ D Q+ L+ ++ E + I+ NT+ D + AL K+
Sbjct: 2002 MKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ 2061
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE 1203
E + L+E+ + E E++ Q+++Q+ K + + E RE
Sbjct: 2062 L-----------EKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 1204 ------ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257
LK++ D + L ++ ++ + +++ +L+ +VRE L S D +
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170
Query: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE 1317
+ F A E +P L + Q++A+ I+ +
Sbjct: 2171 E-----DRKHFGAVE---AKPELSLEV---------------------QLQAERDAIDRK 2201
Query: 1318 KVE---LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374
+ E LE ++ EL K+EEV QL Q LEI+ ++ + E+ E+ K
Sbjct: 2202 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-----LEIQKKESTTRLQELEQENKLFKD 2256
Query: 1375 ESSQLQIAGLEH----LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE-- 1428
+ +L +A E ++ + ++I +KE ++ L+ Q+++ + L KI T+
Sbjct: 2257 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNK 2315
Query: 1429 -IIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
I E+ +LI+ L TQ+E + + C + + EEI + + +++Q++L
Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQE----------CVKRNREEEIEQLNEVIEKLQQEL-- 2363
Query: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547
A I +K ++ + SL EE + ++ + +E QV N+E + L +
Sbjct: 2364 ANIGQKTSMNAH-SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
Query: 1548 RDKLITEMDRSLLENQSL----SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603
++L E+ E +S+ S S+ +A++ L++DK E+E + + +S E
Sbjct: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP----ELEVVLTEDALKSLE 2478
Query: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
Q K ++ + S N+ +++ V A E + Y +++ + + +
Sbjct: 2479 NQTYFKSFEENGK---GSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEM 2535
Query: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEE------ENDRLRAEVHPAG-DTAKECMET 1716
LQ+ ++++ E+ A Q ++ ++E +N + +E + E
Sbjct: 2536 LQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED 2595
Query: 1717 LLSSNASMK----EELER--VKMEYETLSKKFQSLMSEKDSLSEEVQ--DLKHQIEGNVS 1768
L S+ S ELE V+M + +K Q ++EK+ L +E + +L+ +EGN
Sbjct: 2596 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK 2655
Query: 1769 KQANLEATEKHDNQTNVTEEGTQSIPGETE-----EQDSLSMSTRPTCSESVPSAKSANP 1823
KQ E ++ V + T+ E E ++L + T +E + A
Sbjct: 2656 KQREKEK-KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEK 2714
Query: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ--KNKEFSQTLENEKNTLLSQISTK- 1880
+ + + + + Q+++ +A +E+ + ++ ++ E++K + + K
Sbjct: 2715 LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKL 2774
Query: 1881 --------DGELKMLQEEVT----------KMNLLNQQIQEELS--------RVTKLKET 1914
DG LK+ T ++NL ++ EE++ ++ K++E
Sbjct: 2775 SKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQEL 2834
Query: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
E D+E R +++ L + + +LL+ E LK + L ++
Sbjct: 2835 HAAEILDMESRHISETETLK----------REHYVAVQLLKEECGTLKAVIQCLRSKEGS 2884
Query: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
+ E ++ +E G+ G + ++ E + E + D + +K
Sbjct: 2885 SIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS--FPKK 2942
Query: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAE--LASFKVLLDDTQSEAA 2092
I L R V E + L +T+ + +H + +E L K ++ S
Sbjct: 2943 IKGLLRAV------HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKD 2996
Query: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREK 2152
+ L+ + E+ + +S +S + E L ++ L+E+ + L A R E
Sbjct: 2997 LITKMQLQREAEVYDSSQSHESFSDWRGE----LLLALQQVFLEERSVL---LAAFRTEL 3049
Query: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD-DRDRVIDEAKKW 2211
L T + LN ++ +Q+ Q + +M LQ DR ++ E +
Sbjct: 3050 TALGTT--DAVGLLNCLEQRIQE----------QGVEYQAAMECLQKADRRSLLSEIQAL 3097
Query: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
+ + + + E ++ + +L+ ++Q M E+++ +S ++ ++ Q +
Sbjct: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA----TELQEQ 3153
Query: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331
+ ++ V L+ E + +LE T H EL E+K D++ L+++L
Sbjct: 3154 LSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE 3213
Query: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGK 2391
+++ L+ + +++A + S+ ++ DL+ S E + + ++N+ ++ LL+
Sbjct: 3214 QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3273
Query: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451
++ I+ R +D + LS+E+ N+ L+ + + ++ TL ++
Sbjct: 3274 QQKIE----SQRMLYDAQ-------LSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3322
Query: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
+ Q ++ D +S L ++ D + +QLEE+H I+ E E K K +
Sbjct: 3323 HAQLQSS-DGTGQSRPPLPSE-DLLKELQKQLEEKHSRIV--------ELLNETEKYKLD 3372
Query: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571
R M+ ++ ++ + +Q ++ N QK++ E+Q ++E+ +
Sbjct: 3373 SLQTRQQME----KDRQVHRKTLQTEQEAN------TEGQKKMHELQ----SKVEDLQRQ 3418
Query: 2572 LEEKLKESEEANEDLRRSFNALQE-EKQDLSKE--IESLKVSISQLTRQVT-ALQEEGTL 2627
LEEK ++ + + + +R +QE +KQ+L +E ES ++ L T +L + T
Sbjct: 3419 LEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTR 3478
Query: 2628 GLYHAQL---KVKEEEVHRLSALFSSSQKRIAELE---EELVCVQKEAAKKVGEIEDKLK 2681
Q + KE +L + ELE ++L CV A K+ + K
Sbjct: 3479 NWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCV----ASKLQVLPQKAS 3534
Query: 2682 KELKHLHHDAGIMRNETETAEER----VAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737
+ L + ETA++ V E +++ QKL E L + S G
Sbjct: 3535 ERL------------QFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCG 3582
Query: 2738 RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA-FSMN--- 2793
L + +L + + + +L+EQ R+ A ++ FS+N
Sbjct: 3583 SLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGA 3642
Query: 2794 STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL----- 2848
+ E S E N++ L+ + L +++ ++++ S + +L + +H+
Sbjct: 3643 NIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDS-LLQTLSPDSEHVTLKRI 3701
Query: 2849 ---WNELEKFRKS 2858
+ E FRK+
Sbjct: 3702 YGKYLRAESFRKA 3714
Score = 192 bits (488), Expect = 5e-48
Identities = 401/2054 (19%), Positives = 844/2054 (41%), Gaps = 296/2054 (14%)
Query: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
+++ Q ++++A + SST ++L + +++ Q+Q+ +Q +E + + +
Sbjct: 237 KLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTM 296
Query: 1366 HAESLQQKLE------SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKE 1419
LQ+K++ +++ + E ++E + ++EL I ++E+ L +L+ +
Sbjct: 297 QISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTAD 356
Query: 1420 AALTKIQTEIIEQEDLIKALHTQL---EMQAKEHDERIKQLQVELCEMKQKPE-----EI 1471
L ++Q +I+++ IK + +L + + ++ E IKQL + E++++ E
Sbjct: 357 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 1472 GEESRAKQQIQRKL------------QAALISRKEALKENKSLQEELSLA-RGTIERLTK 1518
R +Q+ QRKL Q + ++E ++++ + EE+ +G +E +
Sbjct: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476
Query: 1519 SLADV---ESQVSAQ--------------NKEKDTVLGRLALLQEERDKLITEMDRSLLE 1561
S +++ E Q+ N +K+ + L L+ EE+ L +++ +
Sbjct: 477 SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLV-- 534
Query: 1562 NQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK--IAESTEWQEKHKELQKEYEILL 1619
+ LS S E ++ A + + E + KL + +SL + + AE E KEL+ ++E +
Sbjct: 535 -EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593
Query: 1620 QSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR 1679
+Y+ E+ ++ V E QE E + T+ L E+E+ ++KE +
Sbjct: 594 TNYKIKLEMLEKEKNAVLDRMAESQE-------AELERLRTQ-LLFSHEEELSKLKEDL- 644
Query: 1680 KFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLS 1739
+ + + +E+ D L G K+ ++ L + M +++E ++ E + L
Sbjct: 645 -----EIEHRINIEKLKDNL-------GIHYKQQIDGLQN---EMSQKIETMQFEKDNLI 689
Query: 1740 KKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN-----LEATEKHDNQTNVTEEGTQSIP 1794
K L+ E L + Q L + ++ Q N +E + + + E+ Q +
Sbjct: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQ 749
Query: 1795 GETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE 1854
+TE + E ++ N + + + +++ + Q +ER+ L+
Sbjct: 750 LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDS 808
Query: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK-----------MNLLNQQIQE 1903
K K+K+ E E L+ + + L EE+ K + Q++QE
Sbjct: 809 IKSKSKD--SVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866
Query: 1904 ELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKK 1963
E + + K+K+ E+ K+ E ++L LN + + T ++K+ + + + K
Sbjct: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED----KT 922
Query: 1964 CVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE-------LQELLKE 2016
V+E E + + K+ T++ ++ EK++ +Q+ K+ L E +K
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS 982
Query: 2017 KQQEVKQLQKDCIRYQ--------EKISALERTVKA-LEFVQTESQKDLEITKENLAQAV 2067
+QE +Q+ C + E + + + V + L+ V T + + E + + ++
Sbjct: 983 LKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF 1042
Query: 2068 EHRKKAQAE-LASFKVLLDDTQSEAARVLADNL------------------KLKKE---L 2105
K E SF+ + +S+ +++ D+L KL+KE L
Sbjct: 1043 GEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVL 1102
Query: 2106 QSNKESVKSQMKQK--------DEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE 2157
+S + ++ QM+ + +++ E E + K +++E+L + EK+ +
Sbjct: 1103 KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQ 1162
Query: 2158 TIGEIQVTLNK------KDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW 2211
I ++++ K + K + L L V++ ++ + +L A K
Sbjct: 1163 KIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSY--FLQTLCSVLGEYYTPALKC 1220
Query: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL--EHDKQIWESKAQ 2269
E D S + + E+ L+D ++ E + ++++ E++K +
Sbjct: 1221 EVNAEDKENSGD---YISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL 1277
Query: 2270 TEVQLQQKVCDTLQGENKELLSQLEETRHL-YHSSQNELAKLESELKSLKDQLTDLSNSL 2328
+++ QQ D ++ E E EET L HS L ++ KS L DL +
Sbjct: 1278 SKIWGQQ--TDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT- 1334
Query: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLL 2388
K +EQ LE +I + ++ ++ +YE LQ + S ++ ++
Sbjct: 1335 -KLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITE 1393
Query: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV--LEEENKKAVDKTNQLMETLK 2446
S + + +++ D I E +EE NIV LE++ ++ +++ E K
Sbjct: 1394 SDAQRTMYPGSC-VKKNIDGTI-EFSGEFGVKEETNIVKLLEKQYQEQLEE-----EVAK 1446
Query: 2447 TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ-----QLEERHLS-IILEKDQL-IQ 2499
I +I Q + +S + ++ Q Q E+ + + + L +DQ+ Q
Sbjct: 1447 VIVSMSIAFAQQTE-----LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQ 1501
Query: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKD---SQQKQLL- 2555
+ K KEE + L + + E +++ E + V+TI + S+ K +
Sbjct: 1502 TFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIV 1561
Query: 2556 ---------------EVQLQQNKE-LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQD 2599
QL N+E LE+ +L + +E ++A E LR++ E +++
Sbjct: 1562 RQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRE 1621
Query: 2600 LSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL-FSSSQKRIAEL 2658
+ E L+ I +L RQ+ L + +V EE+ L L + +K EL
Sbjct: 1622 ---DQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678
Query: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Q + GE+E++ KE + + R + E ++ L + +
Sbjct: 1679 RNSSTQTQ-NGNENQGEVEEQTFKEKE-------LDRKPEDVPPEILSNERYALQKANNR 1730
Query: 2719 LLMVTKENKGLTAQI-QSFGRSMSSLQNSRDHANEELDELKRKYDASL--KELAQLKEQG 2775
LL + E TA + ++ GR + + + K + ASL + A+ +
Sbjct: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSS---------KSQSSASLIWRSEAEASVKS 1781
Query: 2776 LLNRERDALLSET--AFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQS 2833
++ E + E+ ++S + N ++ K+ E+ LS +L S
Sbjct: 1782 CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVT-------EEGTELSQRLVRS------ 1828
Query: 2834 FSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRL 2893
A + E + L + S A V+ L +A+S + +
Sbjct: 1829 -GFAGTEIDPENEELMLNIS----------------SRLQAAVEKLLEAISETSSQLEHA 1871
Query: 2894 LKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR 2953
L ++ + QE TE LK Q +E +++ +E+L E + +
Sbjct: 1872 KVTQTELMRESFRQKQEATE--SLKCQ-EELRERLHEESRAREQLAVELSKAEGVIDGYA 1928
Query: 2954 MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPET 3013
EK+ + ER+++E+ I +Q+L N ++EL + Q Q + RQ
Sbjct: 1929 DEKT---LFERQIQEK-TDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMK 1984
Query: 3014 SASPDGSQNLVYETE-LLRTQL----------NDSLKEIHQKELRIQQLNSNFSQLLEEK 3062
+ + Q L+ ETE L++ +L +D K++ E+ +++ S F +L +EK
Sbjct: 1985 AEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK 2044
Query: 3063 NTLSIQLCDTSQSLRENQQHYGDLLNHCAV------------LEKQVQELQAGPLNIDVA 3110
NT + L +Q+L + + L+ A+ ++K Q+L+ P ++
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104
Query: 3111 PGAPQEKNGV--HRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAE 3168
+E + H K ++ E S + Q+ + +E+ +L + E E
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE-------LE 2157
Query: 3169 NALSVAEEQIRRLE 3182
AL V+ + +++E
Sbjct: 2158 QALLVSADTFQKVE 2171
Score = 187 bits (475), Expect = 1e-46
Identities = 454/2216 (20%), Positives = 888/2216 (40%), Gaps = 381/2216 (17%)
Query: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
+E+ K+ E +L Q + + +S DG+ PS Q++ ++ + HH +
Sbjct: 4 EERQKKLEAGKAKLAQFRQRKAQS-DGQSPSKKQKKKRKTSSSKHD-----VSAHHDLNI 57
Query: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEK----VELELKVSSTTSELTKK 1335
+S + + S+ + S EI + + VELE ++S+T + + +
Sbjct: 58 DQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSE 117
Query: 1336 -----------------SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQ 1378
EE F + + ++QG A+ LE +
Sbjct: 118 VNGCSFVMRTGKPTNLLREEEFGVDDSYSEQG----------------AQDSPTHLEMME 161
Query: 1379 LQIAGLEH-LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437
++AG +H + EL +L+E++ ++ E + QL E EAA I +++ +I
Sbjct: 162 SELAGKQHEIEELNRELEEMR--VTYGTEGLQ----QLQEFEAA-------IKQRDGIIT 208
Query: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAA-----LISR 1492
L L+ +E DE +++ +EL E QK + ++ +A + ++ ++ L ++
Sbjct: 209 QLTANLQQARREKDETMREF-LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK 267
Query: 1493 KEALKENKSLQEE---LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ-EER 1548
++ L + L+E+ L + E T ++ ++ ++ E+D + + +E+
Sbjct: 268 QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK 327
Query: 1549 DKLITEMDRSLLENQSLSSSC-ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEK 1607
+ +I E++ ++E + + + L A + L E +E++V++ + +K+ K+ E T ++K
Sbjct: 328 ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL-ELTNSKQK 386
Query: 1608 HKELQKEYEILLQSYENVSNEAER-IQHVVEAVRQEKQELYGKLRSTEANKKET-EKQLQ 1665
++ +E + L+ + E + + Q + V++ +QE KL A E +Q+
Sbjct: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
Query: 1666 EAEQE--------MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717
+ +QE MEEMK + + ++ + + D+++ ++ A + ++
Sbjct: 447 QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL-MNVAINELNIKLQDT 505
Query: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777
S +KEEL + E L ++ + L+ E E++Q + I SK E
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----LNE 560
Query: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS------ESVPSAKSA---NPAVSKD 1828
H + + V E+ I +E + L + + E + K+A A S++
Sbjct: 561 AHKSLSTV-EDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
Query: 1829 ----------FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
SH+E + L++ +++ RI + + + Q ++ +N + +I
Sbjct: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679
Query: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI- 1937
T E L +TK N L + ++KLK+ + + E + Q+ EL I
Sbjct: 680 TMQFEKDNL---ITKQNQL-------ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 1938 ---------GNYCQDVTDAQIKNELLESEMK----NLKKCVSELEEEKQQLVKEK----- 1979
G Q+V + Q+K ELLE +MK +L++ ++LE E L EK
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLED 789
Query: 1980 -----TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK 2034
T V E R +L+ I+ K+ KE++ L++E + L++ CI+ E+
Sbjct: 790 MLKIHTPVSQEERLIFLDSIKSKSKD---SVWEKEIEILIEENE----DLKQQCIQLNEE 842
Query: 2035 ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARV 2094
I T E K+ E+ + L + K + +L K + +
Sbjct: 843 IEKQRNTFSFAE-------KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895
Query: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK--KNMQEKLDALRREK 2152
L + L L++ N +VK + DED E E + EK + EKL+ +REK
Sbjct: 896 LNEELHLQR---INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREK 952
Query: 2153 VHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212
+ L + + ++ L +K E+ L E + SL+ ++++V ++ E
Sbjct: 953 LELSQRLSDLSEQLKQKHGEISFLNE--------------EVKSLKQEKEQVSLRCRELE 998
Query: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEE---LKINISRLEHDKQIWESKAQ 2269
+ ++ E ++ + S L D + M+ E K+N S E K + E K
Sbjct: 999 IIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVS 1055
Query: 2270 -------TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT 2322
E + +Q + D L KE S L T+ S+N+ KL+ EL LK +
Sbjct: 1056 FENMTVGEESKQEQLILDHLPSVTKE--SSLRATQ----PSEND--KLQKELNVLKSEQN 1107
Query: 2323 DLSNSLEK---CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
DL +E C + ++ + + K E + A E L + +
Sbjct: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167
Query: 2380 KEQKIISLLSGKE-EAIQVAIAELRQQHDKEIKE-LENLLSQEEEENIVLEEENKKAVDK 2437
+ Q + + +G E + + + I +L++ +E L+ L S E + A DK
Sbjct: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
Query: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497
N + E + ++ F ++M +L N L+ R I ++
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
Query: 2498 IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557
++ E N KEE L H N E+ ++ + +++ +++D ++ +L E
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHK--------SKLSSLQDLEKTKLEE- 1338
Query: 2558 QLQQNKELENKYAKLEEKLKESEEANED----LRRSFNALQEEKQDLSKEIESLKVSISQ 2613
Q +ELE+ + L+++LKE+E+ E L++ A+ E S ++S+ ++ S
Sbjct: 1339 ---QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395
Query: 2614 LTRQV-----------TALQEEGTLGLYHAQLKVK----------EEEVHRLSALFSSSQ 2652
R + ++ G G+ VK EEEV ++ S +
Sbjct: 1396 AQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF 1455
Query: 2653 KRIAELEEELVCVQKEAAKK----VGEIEDKLKKELKHLHHDAGIMRNETETA--EERVA 2706
+ EL + A+ K V + E E+K G ET +E
Sbjct: 1456 AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFK 1515
Query: 2707 ELARDLVEMEQKLLMVTK------ENKG--LTAQIQSFGR--------------SMSSLQ 2744
L+++L E +++L+ E+K LT + F + S+SS+
Sbjct: 1516 PLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575
Query: 2745 NSRD-HANEE-----LDELKRKY-----------DASLKEL-AQLKEQGLLNRERDALLS 2786
SR NEE EL R+Y A ++++ Q ++Q L E L
Sbjct: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
Query: 2787 ETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL-----HLSSQLEDSYNQVQSFSKAMASL 2841
+ A + EN +S E++ + L +QL L +L +S Q Q+ ++ +
Sbjct: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695
Query: 2842 QNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901
+ + + E E RK P P E+ L +LQ +RLLK L +
Sbjct: 1696 E---EQTFKEKELDRK-----------PEDVPPEI--LSNERYALQKANNRLLKILLEVV 1739
Query: 2902 QQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELH----------- 2950
+ + + I H L + + ++ A I + E S HE H
Sbjct: 1740 KTTAAVEETIGR-HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798
Query: 2951 ----QLRMEKSSW--------EIHERRMK------------EQYLMAISDKDQQLSHLQN 2986
R + + W E+ +R ++ E+ ++ IS + Q + ++
Sbjct: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQ--AAVEK 1856
Query: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
L+ + +SSQ + KV + +++L + E LR +L++ + Q +
Sbjct: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQLAV 1915
Query: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQ----- 3101
+ + +EK Q+ + + + +Q N LE + Q++Q
Sbjct: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975
Query: 3102 -----------AGPL--------------NIDVAPGAPQEKNGVHR--KSDPEELREPQQ 3134
AGP+ ++V A + ++ + + K+ ++ E
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
Query: 3135 SFSEAQQ----QLCNTRQEVNELRKLLEEER----DQRVAAENALSVAEEQIRRLE 3182
F E +Q +L + RQ+ L K LE+ R +Q + E+ V +++I++LE
Sbjct: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091
Score = 121 bits (304), Expect = 1e-26
Identities = 230/1172 (19%), Positives = 497/1172 (42%), Gaps = 183/1172 (15%)
Query: 2119 KDEDLERRLEQAEEK--HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
+DE+ +++LE + K +++K + +++K + + + V+ + D + Q
Sbjct: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHH-DLNIDQS 60
Query: 2177 QEN---------LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Q N ++STV + +++ S E E+ FS ++S EI
Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHS---------GEITSHEQGFSVELES---EIS 108
Query: 2228 LKEDNCS--------VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC 2279
D+CS V++ + EE ++ S E Q + T +++ +
Sbjct: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQ----DSPTHLEMMESEL 164
Query: 2280 DTLQGENKELLSQLEETRHLYHSSQ-NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338
Q E +EL +LEE R Y + +L + E+ +K +T L+ +L++ + +K
Sbjct: 165 AGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDET 224
Query: 2339 EGIIRQQEADIQNSKFSYEQLETD---------------LQASRELTSRLHEEINMKEQK 2383
+ Q + ++QL+ LQA +++ + H++ ++
Sbjct: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT--HQQQLEEQDH 282
Query: 2384 IISLLSGKEEAIQVAIAELRQQ----HDKEIKELENLLSQE-EEENIVLEEENKKAVD-- 2436
++ K+E + I+ L+++ ++ K++EN +E +E+ ++EE N K ++
Sbjct: 283 LLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEE 342
Query: 2437 -KTNQLMETLKTIKK---ENIQQKAQLDSFVKSM-----SSLQNDRD------RIVGDYQ 2481
KT +L + L T K E +Q Q + +K+M +S Q +R +++G +
Sbjct: 343 KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402
Query: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541
+L++R+ + ++Q E + E+ LR+ +D++ + +++Q +++L
Sbjct: 403 ELQKRNHKDSQFETDIVQRMEQETQRKLEQ---LRAELDEMYGQ------QIVQMKQELI 453
Query: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601
+ Q+ E++ + E+EN + + +E+ + + + N L + QD +
Sbjct: 454 R------QHMAQMEEMKTRHKGEMENA-LRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506
Query: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661
+ E LK + + + ALQ + L +L E++ R + + ++ E +
Sbjct: 507 SQKEKLKEELGLILEEKCALQRQ--LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564
Query: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721
L V+ A+ V E + + ELKH E E ++ KL M
Sbjct: 565 LSTVEDLKAEIVSASESRKELELKH----------EAEVTNYKI------------KLEM 602
Query: 2722 VTKE-NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780
+ KE N L +S + L+ ++EE EL + LKE +++ + + +
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEE--ELSK-----LKEDLEIEHRINIEKL 655
Query: 2781 RDALLSETAFSMNSTEENSLSHLEKL---NQQLLSKDEQLLHLSSQLED-SYNQVQSFSK 2836
+D L ++ + +E + L++K QL+ S+L+D + V S S+
Sbjct: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
Query: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND------- 2889
M NE L E+E R+ E+ K + + + L+K M +ND
Sbjct: 716 EMTLQINE---LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 2890 ---RDRLLKELKNLQQQYLQINQEITE------LHPLKAQLQE--YQDKTKAFQIMQEEL 2938
+ +LK+ K + L+I+ +++ L +K++ ++ ++ + + E+L
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
Query: 2939 RQENLSWQHELHQLR----MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994
+Q+ + E+ + R + ++E++ + ++E+Y + KD L +N +EL
Sbjct: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLEDSKNK-QELEYK 890
Query: 2995 SSQTQPLKVQYQRQASPET----SASPDGSQNLVYET-------ELLRTQLNDSLKEIHQ 3043
S + + ++ +P T S+ D + V ET E T+L + L+ +
Sbjct: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
Query: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG-------DLLNHCAVLEKQ 3096
++L + Q S+ S+ L++K+ L + +SL++ ++ ++NH Q
Sbjct: 951 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010
Query: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156
+ Q L V + G + + +SF E + + + + +
Sbjct: 1011 SCDTQVSSLLDGVVTMTSRGAEG--------SVSKVNKSFGEESKIMVEDKVSFENM-TV 1061
Query: 3157 LEEERDQRVAAENALSVAEE-QIRRLEHSEWD 3187
EE + +++ ++ SV +E +R + SE D
Sbjct: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSEND 1093
Score = 75.1 bits (183), Expect = 1e-12
Identities = 119/591 (20%), Positives = 239/591 (40%), Gaps = 64/591 (10%)
Query: 23 DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82
+ N++ L + ++ ++QE+L+ + +V ELK + Q ++L+ +A
Sbjct: 3123 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3182
Query: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
+ K +++ +L K K ++ + + ++ + E++ +K +S +
Sbjct: 3183 HKHLK----ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3238
Query: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
+ E+E +K L+ +++ LQ L Q +Q S + E M Q EE L
Sbjct: 3239 KEELEDLKFSLESQKQ--RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296
Query: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHED-ELLQLVTQADVETEMQQKLRVLQRKL 261
+ Q+ ++ + +RE + + + LH + Q+ + L+ LQ++L
Sbjct: 3297 ELQV----LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3352
Query: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
EE +++V+LL + E+ Q QQME + R T++TE+E +
Sbjct: 3353 EEK------HSRIVELLNE----TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN---- 3398
Query: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE------QKHKAEME 375
E + H LQ ++ L Q E+ Q +L+ L+ QK + E E
Sbjct: 3399 -------TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
Query: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE----------- 424
EK L + E + + +LQ K E + + + +E
Sbjct: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHE 3511
Query: 425 -DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483
+ ++QK + ++ L LP + E + D Q +E I LQK + + E
Sbjct: 3512 LEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQK-LTGQQGE 3570
Query: 484 KGALLLSSIE----LEELKAENEKLSSQITLL-----EAQNRTGEADREVSEISIVDIAN 534
+ +L+ S E L +N +L+ I+ L + +N + + ++
Sbjct: 3571 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGR 3630
Query: 535 KRSSSAEESGQDVLENTFSQK----HKELSVLLLEMKEAQEEIAFLKLQLQ 581
SS +G +E + + ++E L +K A+ E+ LK +L+
Sbjct: 3631 DNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELR 3681
Score = 33.9 bits (76), Expect = 2.7
Identities = 64/324 (19%), Positives = 124/324 (38%), Gaps = 56/324 (17%)
Query: 20 DDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK- 78
++T++ L E D + + T + QE ++ + EL+ + QL++K
Sbjct: 3364 NETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKR 3423
Query: 79 ---------------------DEALQEERKAADNKIKKLKLHAKA--KLTS--LNKYIEE 113
+ L+ E K +I L+ LTS ++ +
Sbjct: 3424 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQ 3483
Query: 114 MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173
K +G T+ + +L + + T E+E I+ KLQ +++ L Q +E
Sbjct: 3484 QKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ----CVASKLQVLPQKASE 3535
Query: 174 QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH 233
+ + + E+F+ +++ + +E I LQ +L+ Q E+ + ++
Sbjct: 3536 RLQFETADDEDFIWVQENI---DEIILQLQ-KLTGQQGEEPSLVSPSTSCGSLTERLLRQ 3591
Query: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEH---------------EESLVGRAQVVDLL 278
EL ++Q TE + LR + KLEE SL G A + ++
Sbjct: 3592 NAELTGHISQL---TEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAII 3648
Query: 279 QQELTAAEQRNQILSQQLQQMEAE 302
E + L + L++ EAE
Sbjct: 3649 ASEKEVWNREKLTLQKSLKRAEAE 3672
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 306 bits (783), Expect = 3e-82
Identities = 721/3514 (20%), Positives = 1451/3514 (41%), Gaps = 620/3514 (17%)
Query: 64 LKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK-------------- 109
++D RQK ++ + A +RKA + K K + TS +K
Sbjct: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60
Query: 110 -----YIEEMKAQGGTVLPTEP-----QSEEQLSKHDKSSTEEEMEIEKIKHKLQEK--- 156
YI + TV+P S E S S E E EI +
Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120
Query: 157 ----------EELISTLQAQLTQAQAEQPAQSS-TEMEEFVMMKQQLQEKEEFISTLQAQ 205
L+ + + + +EQ AQ S T +E MM+ +L K+ I L +
Sbjct: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE---MMESELAGKQHEIEELNRE 177
Query: 206 LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265
L + + + + + ++ FE ++ + + QL LQ+ E +
Sbjct: 178 LEEMRVTYGTEGLQQLQE--FEAAIKQRDGIITQLTAN-------------LQQARREKD 222
Query: 266 ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK--ILLEK 323
E++ + L ELT Q+ QI QQLQ E N+ ++ + ++K IL +
Sbjct: 223 ETMR------EFL--ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 324 MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
+LE + L + ++E + F Q E+E + +E +K E++EK + I
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEEIQEKETIIEE 333
Query: 384 LQKTGQELQSACDALKDQ---NSKLLQDKNEQAVQSAQTIQQLEDQL-------QQKSKE 433
L E + LKD+ KLL + EQ VQ Q I+ ++ +L +Q S+E
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
I Q + + Q + F + + T+ + L+ + E+ ++ + +
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL- 452
Query: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
+ + A+ E++ ++ + A R S I++ + K + A L++T S
Sbjct: 453 IRQHMAQMEEMKTR-----HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
Query: 554 QKHK---ELSVLLLE-------MKEAQEEIAFLKLQLQGKRAEEAD--------HEVLDQ 595
QK K EL ++L E +++ EE++F + Q+Q R A+ H+ L
Sbjct: 508 QKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST 567
Query: 596 KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLN 655
E + E + + ++ L+ + + N + L +EKE+ + + S+E L
Sbjct: 568 VEDLKAEIVSASESRKELELKHEAE----VTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 656 DAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI-LELELNFHKAQE----IYEKN 710
+L + H++EL +LK + +E +N K ++ Y++
Sbjct: 624 RLRTQLLFS-----------------HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ 666
Query: 711 LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLE 770
+D E+S Q IE + DN L +++QL+ ++ +L + + K E
Sbjct: 667 IDGLQNEMS---QKIETMQFEKDN-------LITKQNQLILEISKLKDLQQSLVNSKSEE 716
Query: 771 MNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ 829
M L E Q+ ++ Q + L +++ L ++ + + +++ +N+L + Q +
Sbjct: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776
Query: 830 STLIRSLQSQLQN--KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKR 887
+++++ + L++ K + ER+ + S + ++ +KE+EI L+E+
Sbjct: 777 NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------LIEENE 830
Query: 888 DVETLQQTIEEKDQ-QVTEISFSMTEKMVQLN----EEKFSLGVEIK------TLKEQLN 936
D++ QQ I+ ++ + +FS EK ++N +E+++ +++K K++L
Sbjct: 831 DLK--QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELE 888
Query: 937 LLSRAEEAKKE-QVEEDNEVSSGLKQN-YD----------EMSPAGQISKEELQHEFDLL 984
S+ + +E ++ N + +K + +D EM + EL + ++
Sbjct: 889 YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVT 948
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
K+E + ++L K+ +S L EE+ +LK E K+++ L E E+ +
Sbjct: 949 KREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE-KEQVSLRCREL-EIIINHNRA 1006
Query: 1045 EYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD--------LEEKLAAEEQFQALVKQ 1096
E + C T ++ + T E + + K +E+K++ E +
Sbjct: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066
Query: 1097 MNQTLQDK----TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE------TVV 1146
Q + D T + L + SEN + ++L N S+ + + L E ++V
Sbjct: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKEL---NVLKSEQNDLRLQMEAQRICLSLV 1123
Query: 1147 ISPPCTGSSEHWKPE--------LEEKILALEKEKEQLQKKLQEALTSRKA--------- 1189
S E+ + E EE I A E++ ++LQK Q L + K
Sbjct: 1124 YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKP 1183
Query: 1190 -------ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRE 1242
+ K E+ + + L +Y + + +++ EN GD + + + E
Sbjct: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP--E 1241
Query: 1243 SIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG- 1301
D + D QE+ + L K TE+++ VL++ L W D L+ G
Sbjct: 1242 LQDYRYEVQDFQEN------MHTLLNKVTEEYNKLLVLQTRLSKIW-GQQTDGMKLEFGE 1294
Query: 1302 -------TSVAQIKAQLKEIEAEKVELELKVSSTTS-ELTKKSEEVFQLQEQINKQGLEI 1353
T I +Q+ +E V + K+SS E TK E+V +L+ I+ ++
Sbjct: 1295 ENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQL 1354
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSG 1413
+ + ++EAE+H LQ++L++ + P L +I++ + + G
Sbjct: 1355 KETEQ-NYEAEIHC--LQKRLQAVSES--------TVPPSLPVDSVVITESDAQRTMYPG 1403
Query: 1414 QLSEKEAALT---KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470
+K T + + E+ +++K L Q + Q +E + ++ V + + E
Sbjct: 1404 SCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL---EEEVAKVIVSMSIAFAQQTE 1460
Query: 1471 IGEESRAKQQIQRKLQAALISRKEA--LKENKSLQEELSLA---------RGTIERLTKS 1519
+ S K+ QA + ++E E K Q+++ + + L+K
Sbjct: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE 1520
Query: 1520 LADVESQVSAQNKE-------KDTVLGRLALLQEE---RDKLITEMDRSLLENQSLSSSC 1569
L + ++ N + KD VL + EE +DK + +S+ + S+SS
Sbjct: 1521 LGEHGKEILLSNSDPHDIPESKDCVL----TISEEMFSKDKTFI-VRQSIHDEISVSSMD 1575
Query: 1570 ESLKLAL--EGLTEDKEKLVKE-------IESLKSSKIAESTEWQEKHKELQKEYEIL-- 1618
S +L L E L + +++LV++ E L+ + + + +E ++LQ+E + L
Sbjct: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
Query: 1619 -LQSYENVSNE---AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674
L ++ NE +ER + ++E + KQ + + Q Q + E+
Sbjct: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695
Query: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME 1734
+E+ K E+E DR +V P + E ++N +K LE VK
Sbjct: 1696 EEQTFK------------EKELDRKPEDV-PPEILSNERYALQKANNRLLKILLEVVKTT 1742
Query: 1735 ---YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
ET+ + ++ ++ S S+ L + E S ++ + H+ T VT+E
Sbjct: 1743 AAVEETIGRHVLGIL-DRSSKSQSSASLIWRSEAEASVKSCV-----HEEHTRVTDESIP 1796
Query: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851
S G ++ ++M ++ T +E Q++ ++ AG
Sbjct: 1797 SYSGSDMPRNDINMWSKVT----------------------EEGTELSQRL--VRSGFAG 1832
Query: 1852 LE---EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908
E E ++ S L+ LL IS +L+ +VT+ L+ + +++
Sbjct: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE--HAKVTQTELMRESFRQKQEAT 1890
Query: 1909 TKLKETAE-----EEKDDLEERLMNQLAELNGSIGNYCQDVT--DAQIKN-----ELLES 1956
LK E E+ E+L +L++ G I Y + T + QI+ + LE
Sbjct: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950
Query: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
E+ + ELE E+QQ+ +E+ + + KE ++ A+ P + +E ++L+KE
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQ--KEAMK----AEAGPVEQQLLQETEKLMKE 2004
Query: 2017 KQQEVKQLQKDCIRYQEKISALERTV--KALEFVQTESQK-----DLEITKENLAQAVEH 2069
K + Q +K Q+++ ALE V + F++ E +K DL + L + +E
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064
Query: 2070 RKKAQAELA-------------------SFKVL-----LDDTQSEAARVLADNLKLK--- 2102
+K E A KV+ + + Q+ LA++LK K
Sbjct: 2065 MRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDK 2124
Query: 2103 -KELQSNKESVKSQMKQKDEDLE------RRLEQA----EEKH---------LKEKKNMQ 2142
EL +KE ++ +++++E++E R LEQA + KH L + +Q
Sbjct: 2125 CSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQ 2184
Query: 2143 EKLDAL-RREK--VHLEETIGEIQVTLNKKDKEVQQLQENLD----STVTQLAAFTKSMS 2195
+ DA+ R+EK +LEE + + + L K++EVQQL L+ + T+L +
Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2244
Query: 2196 SLQDDRDRVIDEAKKWER-----------KFSDAIQSKEEEIRLKEDNCSVLKDQLR--- 2241
+DD +++ K+ + KF+ IQ KE EI + + L+ QL+
Sbjct: 2245 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITT 2304
Query: 2242 ------QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEE 2295
+ + + +L+ I L D++ + + E++ +V + LQ +EL + ++
Sbjct: 2305 DNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ---QELANIGQK 2361
Query: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
T HS E L+ +L + + L +E E+ ++ ++++ + F
Sbjct: 2362 TSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE-------TNFK 2414
Query: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
QL +L + + + + + + S E ++ VAI L K+ ELE
Sbjct: 2415 MNQLTQELFS-----------LKRERESVEKIQSIPENSVNVAIDHL----SKDKPELEV 2459
Query: 2416 LLSQEEEENIVLE------EENKKA--VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMS 2467
+L+++ +++ + EEN K ++ +L++ T+ +++ +L K +
Sbjct: 2460 VLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL----ELTQCYKQIK 2515
Query: 2468 SLQND--------RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
+Q + +IV + +EE+ + ++ + QL EA E K ++ + + S
Sbjct: 2516 DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL--EAVQEYAKFCQDNQTISSEP 2573
Query: 2520 DDLNSEN----------AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKY 2569
+ N +N + + A ++ E +QV+ + S + +V++ + LE +
Sbjct: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633
Query: 2570 AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGL 2629
LE L++ E NE +R ++EK+ +++E LK + T + +E G
Sbjct: 2634 KLLE--LQKLLEGNEKKQR-----EKEKKRSPQDVEVLKTT----TELFHSNEESG---- 2678
Query: 2630 YHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA---KKVGEIEDKL---KKE 2683
+ +L+ E A +S +++ +L+EEL+ + K + ++ D L K++
Sbjct: 2679 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2738
Query: 2684 LKHLHHDAGIMRNETETAEERVA--------ELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
L L + +ETE E + A +L++ + L ++ N+ +++
Sbjct: 2739 LSILEKE-----DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN 2793
Query: 2736 FGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLN------RERDALLSETA 2789
G + +LQ+ + ++EE+ E+ ++ ++++ +L +L+ E + L E
Sbjct: 2794 AGIQI-NLQS--ECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHY 2850
Query: 2790 FSMNSTEENSLSHLEKLNQQLLSKD----EQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2845
++ +E L+ + Q L SK+ +L H D+Y + S S +
Sbjct: 2851 VAVQLLKE-ECGTLKAVIQCLRSKEGSSIPELAH-----SDAYQTREICSSDSGSDWGQG 2904
Query: 2846 DHLWNELEKFRKSEEGK-QRSAAQPSTSPAEVQSLKKAM------------SSLQNDRDR 2892
+L + + F + EG+ + S + + P +++ L +A+ S + D
Sbjct: 2905 IYLTHS-QGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2963
Query: 2893 LLKELKN--LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLS-WQHE- 2948
++++ L+++ IN I+ L L ++Q ++ ++ E+ S W+ E
Sbjct: 2964 SIQQVSEPWLEERKAYIN-TISSLKDLITKMQLQREA----EVYDSSQSHESFSDWRGEL 3018
Query: 2949 ---LHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE--------------- 2990
L Q+ +E+ S + R E + +D L+ L+ I+E
Sbjct: 3019 LLALQQVFLEERSVLLAAFR-TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKA 3077
Query: 2991 -LRSSSSQTQPL-------KVQYQRQASPETSASPDGSQNLVY-ETELLRTQLNDSLKEI 3041
RS S+ Q L K+ +R+ E + N+ ++++L Q+ S +
Sbjct: 3078 DRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKD 3137
Query: 3042 HQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDL----------LNHCA 3091
EL+ +QL+S + E K+ L+ + +L+ +H +L +
Sbjct: 3138 RATELQ-EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVH 3196
Query: 3092 VLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVN 3151
+L + Q + A + K G + D EEL + + S +Q+ +
Sbjct: 3197 LLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLE 3256
Query: 3152 ELRKLLEEERDQRVAAENAL---SVAEEQIRRLE 3182
+ ++LL E + Q++ ++ L ++EEQ R LE
Sbjct: 3257 QQKQLLNESQ-QKIESQRMLYDAQLSEEQGRNLE 3289
Score = 299 bits (765), Expect = 3e-80
Identities = 713/3433 (20%), Positives = 1420/3433 (41%), Gaps = 610/3433 (17%)
Query: 35 HQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIK 94
H++S E + Q QE EQL EL ++ Q+ VQ++Q+ L + A +++
Sbjct: 409 HKDSQFE-TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQE---LIRQHMA---QME 461
Query: 95 KLKLHAKAKL-TSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
++K K ++ +L Y + L +E + D +S +E+++ E++ L
Sbjct: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK-EELGLIL 520
Query: 154 QEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ 213
+EK LQ QL E S E+ +Q + E+E ++ +A S + E
Sbjct: 521 EEK----CALQRQLEDLVEEL----SFSREQIQRARQTIAEQESKLN--EAHKSLSTVED 570
Query: 214 AAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLR--VLQRKLEEHEESLVG- 270
++V ++R E +++ HE E VT ++ EM +K + VL R E E L
Sbjct: 571 LKAEIVSASESRKELELK-HEAE----VTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625
Query: 271 RAQVVDLLQQELTAAEQRNQI--------LSQQL-----QQMEAEHNTLRNTVETEREES 317
R Q++ ++EL+ ++ +I L L QQ++ N + +ET + E
Sbjct: 626 RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEK 685
Query: 318 KILLEKME---LEVAERK---------------LSFHNLQEEMHHLLEQFEQAGQAQAEL 359
L+ K LE+++ K L + LQ+E+ L ++ ++ G + E+
Sbjct: 686 DNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEV 745
Query: 360 ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQD---------KN 410
+ E K +M+EK + LQ+ +L++ LKD+ K L+D +
Sbjct: 746 QELQLKTELLEK-QMKEKEN---DLQEKFAQLEAENSILKDEK-KTLEDMLKIHTPVSQE 800
Query: 411 EQAVQSAQTIQQLEDQLQQKSKEI----SQFLNRLPLQQHETASQT----SFPDVYNEGT 462
E+ + + +D + +K EI ++ L + +Q +E + SF + E
Sbjct: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELE---ELKAENEKLSSQI---TLLEAQNR 516
+E A L K +LE+ K + ELE +LKA NE+L Q T ++ ++
Sbjct: 861 YQELQEEYACLLKVKDDLEDSK-----NKQELEYKSKLKALNEELHLQRINPTTVKMKSS 915
Query: 517 TGEADR----------EVSEISIVDIANKRSSSAEESGQ-----DVLENTFSQKHKELSV 561
+ D+ EV E ++ K + E + L QKH E+S
Sbjct: 916 VFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISF 975
Query: 562 LLLE---MKEAQEEIAF----LKLQLQGKRAEEADH------EVLDQKEMKQMEGEGIAP 608
L E +K+ +E+++ L++ + RAE +LD G +
Sbjct: 976 LNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSV 1035
Query: 609 IKM--------KVFLEDTGQDFPLMPNEESS--------LPAVEKEQASTEHQSRTSEEI 652
K+ K+ +ED + EES LP+V KE S+ ++ SE
Sbjct: 1036 SKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE--SSLRATQPSEND 1093
Query: 653 SLNDAGVELKSTKQDGDKSLSA----VPDIGQCHQDELERLKSQILELELNFHKAQEIYE 708
L LKS + D + A + + H D++ + L K + I+
Sbjct: 1094 KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFA 1153
Query: 709 KNLDEKAKEISNLNQLIEEFKKNADNNSSAFT----------ALSEERDQLLSQVKELSM 758
+ +EK KE+ ++QL + K + A+SEE L + S+
Sbjct: 1154 Q--EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL--CSV 1209
Query: 759 VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL---------LTEQIHSLSIEAKSKD 809
+ E + E+N + E DY S+ L E +H+L + +
Sbjct: 1210 LGEYYTPALKCEVNAEDKENSG--DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY 1267
Query: 810 VKIEVLQNEL--------DDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS-K 860
K+ VLQ L D ++L+F E++ L +E+E L ++ ++
Sbjct: 1268 NKLLVLQTRLSKIWGQQTDGMKLEFGEEN---------LPKEETEFLSIHSQMTNLEDID 1318
Query: 861 VEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEE 920
V S+ S ++LE TK+++ + E + + +LQQ ++E +Q + +++ ++E
Sbjct: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378
Query: 921 KF--SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD-EMSPAGQISKEEL 977
SL V+ + E + S +K+N D + +G+ +E
Sbjct: 1379 TVPPSLPVDSVVITES-------------DAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425
Query: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV 1037
+ LL+K+ +++ LEEE+A + S +TE +
Sbjct: 1426 TNIVKLLEKQYQEQ--------------------LEEEVAKVI-VSMSIAFAQQTELSRI 1464
Query: 1038 EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQM 1097
KEN S++ QE + + +S+ ++ Q + +F+ K +
Sbjct: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFE-------TVDVKFKEEFKPL 1517
Query: 1098 NQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157
++ L + +I L ++ + ++T + + D +V++++ +
Sbjct: 1518 SKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDAS 1577
Query: 1158 WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE 1217
+ L E+ LE +++L ++ QE + + + + + RE+ +Q +++ RL
Sbjct: 1578 RQLMLNEE--QLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635
Query: 1218 QFDEQSK-ENENIGDQ-----------LRQLQIQVRESIDGKL--PSTDQQESCSSTPGL 1263
Q ++S +NEN+ + L+QL + RE + +L ST Q + +
Sbjct: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695
Query: 1264 EEPLFKATE----QHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319
EE FK E P + SN + + L+ V + A ++E V
Sbjct: 1696 EEQTFKEKELDRKPEDVPPEILSN--ERYALQKANNRLLKILLEVVKTTAAVEETIGRHV 1753
Query: 1320 ELELKVSS---TTSELTKKSEEVFQLQEQINKQGLEI--ESLKTVS------HEAEVHAE 1368
L SS +++ L +SE ++ ++++ + ES+ + S ++ + ++
Sbjct: 1754 LGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSK 1813
Query: 1369 SLQQKLESSQLQIAGLEHLRELQPKLDEL--------QKLISKKEEDVSYLSGQLSEKEA 1420
++ E SQ + E+ P+ +EL Q + K E +S S QL +
Sbjct: 1814 VTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKV 1873
Query: 1421 ALTKIQTEIIEQ-EDLIKALHTQLEMQAKEHDERI--KQLQVELCEMKQKPEEIGEESRA 1477
T++ E Q ++ ++L Q E++ + H+E +QL VEL + + + +E
Sbjct: 1874 TQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL 1933
Query: 1478 -KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
++QIQ K +I R L++EL A ++ L ++ + +++K+
Sbjct: 1934 FERQIQEKTD--IIDR---------LEQELLCASNRLQELEAEQQQIQEERELLSRQKEA 1982
Query: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCES----LKLALEGLTEDKEKLVKEIES 1592
+ ++++ L+ E ++ + E + E L+ ++ L D E+ V
Sbjct: 1983 MKAEAGPVEQQ---LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIE 2039
Query: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652
L+ K E + +++++ L+K+ E + + + + + E H + +QE Q+L +L+
Sbjct: 2040 LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDRE---HERDVFQQEIQKLEQQLKV 2096
Query: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAK---SKQQKILELEEENDRLRAEVHPAGDT 1709
+ +E Q +E EQ +KEK K ++ SK+Q +++E N+ E+
Sbjct: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE----EIEKLEFR 2152
Query: 1710 AKECMETLLSSNA-------------------SMKEELERVKMEYETLSKKFQSLMSEKD 1750
+E + LL + + ++ ++R + E L ++ + E +
Sbjct: 2153 VRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2212
Query: 1751 SLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPT 1810
+ +EEVQ L Q+E + K+ + ++ + + + ++ + + +E D++S T
Sbjct: 2213 NKNEEVQQLHMQLE--IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS-----T 2265
Query: 1811 CSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEK 1870
+ V K A K+ +IDQL E++ L+++ + + ++ +E EK
Sbjct: 2266 QDQHVLFGKFAQIIQEKEV-----------EIDQLNEQVTKLQQQLKITTD-NKVIE-EK 2312
Query: 1871 NTLLSQISTK------DGEL--KMLQEEVTKMNLLNQQIQEELSRVTKLKE----TAEEE 1918
N L+ + T+ D E + +EE+ ++N + +++Q+EL+ + + + EE
Sbjct: 2313 NELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE 2372
Query: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978
D L+ +L +AE + + Q+ E EM +K + E + QL +E
Sbjct: 2373 ADSLKHQLDVVIAE---------KLALEQQV--ETANEEMTFMKNVLKETNFKMNQLTQE 2421
Query: 1979 KTKVESEIRKEYLEKIQGAQKEPGN------KSHAKELQELLKE-------KQQEVKQLQ 2025
++ E +E +EKIQ + N EL+ +L E Q K +
Sbjct: 2422 LFSLKRE--RESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFE 2479
Query: 2026 KD----CIRYQEKISALERTVKALEFVQTESQKDLEITKE--------------NLAQAV 2067
++ I + ++ LE TV A + T+ K ++ +E NL + V
Sbjct: 2480 ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2539
Query: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD-----ED 2122
E +K A L S ++ L+ Q E A+ DN + E + +Q+++ +
Sbjct: 2540 E--EKVAAALVS-QIQLEAVQ-EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISA 2595
Query: 2123 LERRLEQAEEKHLKEKKNM---QEKLDALRREKVHLEETIGEIQVTLN---KKDKEVQQL 2176
L R+ + E + ++ ++ +E+++ + + E+ + E+Q L KK +E ++
Sbjct: 2596 LTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKK 2655
Query: 2177 QENLD----STVTQL------AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ D T T+L + F + +L+ + E ++ K + +EE+
Sbjct: 2656 RSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEK----AEKLQEEL 2711
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC--DTLQG 2284
+KE N + L+ L Q+ H+ E K +S LE + + TEVQ +K C + L
Sbjct: 2712 LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE-------TEVQESKKACMFEPLPI 2764
Query: 2285 E-NKELLSQLEETRHLYHSSQNE--LAK-------LESELKS--LKDQLTDLSNSLEKCK 2332
+ +K + SQ + T + S+Q L K L+SE S + + ++ + +EK +
Sbjct: 2765 KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2824
Query: 2333 EQKG------------NLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMK 2380
E E + R+ +Q K L+ +Q R E+
Sbjct: 2825 ELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHS 2884
Query: 2381 E----QKIISLLSGKE----------EAIQVAIAELRQQHD-------KEIKELENLLSQ 2419
+ ++I S SG + + +A ++ + K+IK L +
Sbjct: 2885 DAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHN 2944
Query: 2420 EEEENIVLEE-------------------ENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
E + + L E E +KA T ++ L I K +Q++A++
Sbjct: 2945 EGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL--ITKMQLQREAEVY 3002
Query: 2461 SFVKSMSSLQNDRDRIVGDYQQ--LEERHLSIILEKDQLIQEAAAE--------NNKLKE 2510
+S S + R ++ QQ LEER + + + +L + +++E
Sbjct: 3003 DSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE 3062
Query: 2511 EIRGLRSHMDDLN-SENAKLDAELIQYREDLN-QVITIKDSQQ-----KQLLEVQLQQNK 2563
+ ++ M+ L ++ L +E+ +N + IT+K Q+ ++LLE +QQ
Sbjct: 3063 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQK- 3121
Query: 2564 ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI-SQLTRQVTALQ 2622
+++ +++ +L ++ +L+ ++ + +L E+ K+ + + L Q L+
Sbjct: 3122 --QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLK 3179
Query: 2623 EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK 2682
E L + ++K K +EVH L+ +S QK+ EL+ L +KE AK +G E++ K+
Sbjct: 3180 E---LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL---EKEKAK-LGRSEERDKE 3232
Query: 2683 ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS 2742
EL+ L + E+ ++R +L +L+ +QK L+ + K + +Q + +S
Sbjct: 3233 ELEDL-------KFSLESQKQRNLQL--NLLLEQQKQLLNESQQK-IESQRMLYDAQLSE 3282
Query: 2743 LQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSH 2802
Q N EL L ++E++ L+RER+ L S + T ++
Sbjct: 3283 EQGR----NLELQVLLESEKVRIREMSST-----LDRERE--LHAQLQSSDGTGQS---- 3327
Query: 2803 LEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR-KSEEG 2861
+ L ++ L L QLE+ ++++ L NE EK++ S +
Sbjct: 3328 -----RPPLPSEDLLKELQKQLEEKHSRIVE--------------LLNETEKYKLDSLQT 3368
Query: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921
+Q+ +Q+ ++A + Q L ++++LQ+Q + Q++ + L +
Sbjct: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV---YKLDLEG 3425
Query: 2922 QEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL 2981
Q Q + FQ QE R+E + L+Q E ++W + R + L + + +
Sbjct: 3426 QRLQGIMQEFQ-KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKE 3484
Query: 2982 SHLQNLI-----------------RELRSSSSQTQPLKVQYQRQASPETSASPD------ 3018
S+ LI ++L+ +S+ Q L + + ET+ D
Sbjct: 3485 SNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE 3544
Query: 3019 GSQNLVYETELLRTQLND---------SLKEIHQKELRIQ-QLNSNFSQLLEEKNTLSIQ 3068
++ + + L Q + S + ++ LR +L + SQL EEKN L
Sbjct: 3545 NIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM 3604
Query: 3069 LCDTSQSLRENQQ 3081
+ + +R +Q
Sbjct: 3605 VMKLEEQIRWYRQ 3617
Score = 283 bits (724), Expect = 2e-75
Identities = 669/3382 (19%), Positives = 1382/3382 (40%), Gaps = 530/3382 (15%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKL 96
E D + N+ +E++QE+ E+L ++ ++EE+K
Sbjct: 311 EQDKKVENSNKEEIQEKETIIEELNTKI-----------------IEEEKKT-------- 345
Query: 97 KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK 156
L K KLT+ +K + E+ +EQ+ + ++ ++E+ K K ++
Sbjct: 346 -LELKDKLTTADKLLGEL--------------QEQIVQKNQEIKNMKLELTNSKQKERQS 390
Query: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
E I L + + Q S E + M+Q+ Q K E + ++ Q Q Q
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450
Query: 217 QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVD 276
+++R+ A+ E H+ E+ + T + +++++ + E L +
Sbjct: 451 ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
Query: 277 LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336
L++EL + L +QL+ + E + R ++ R+ I ++ +L A + LS
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ--TIAEQESKLNEAHKSLS-- 566
Query: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSA--LEQKHKAEMEEKTSHILSLQKTGQELQSA 394
+ L + A +++ ELE ++ A K K EM EK + + L + + ++
Sbjct: 567 ----TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAV-LDRMAESQEAE 621
Query: 395 CDALK--------DQNSKLLQD------------KNEQAVQSAQTIQQLEDQLQQKSKEI 434
+ L+ ++ SKL +D K+ + Q I L++++ QK + +
Sbjct: 622 LERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
Query: 435 SQFLNRLPLQQHETASQTS-FPDVYNEGTQAVTEE---NIASLQKRVVEL---ENEKGAL 487
+ L +Q++ + S D+ + +EE I LQK + L E EKG L
Sbjct: 682 QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL 741
Query: 488 LLSSIELE--------ELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS 539
EL+ ++K + L + LEA+N + +++ E D+ +
Sbjct: 742 EQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE----DMLKIHTPV 797
Query: 540 AEESGQDVLENTFSQK-----HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
++E L++ S+ KE+ +L+ E ++ +++ L +++ +R + E
Sbjct: 798 SQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNF 857
Query: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
+ ++++ E +K+K LED+ L +S L A+ +E H R +
Sbjct: 858 EVNYQELQEEYACLLKVKDDLEDSKNKQEL--EYKSKLKALNEEL----HLQR------I 905
Query: 655 NDAGVELKSTKQDGDKSLSA-VPDIGQCHQ-------DELERLKSQILELELNFHKAQEI 706
N V++KS+ D DK+ A ++G+ + ++LE K + LEL E
Sbjct: 906 NPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE- 964
Query: 707 YEKNLDEKAKEISNLNQLIEEFKK-------------------NADNNSSAFTALSEERD 747
L +K EIS LN+ ++ K+ A+N S T +S D
Sbjct: 965 ---QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021
Query: 748 QLLSQVKELSMVTELRAQVKQLEMNLAEAER---QRRLDYESQTAHDNLLTEQI---HSL 801
+++ V ++ + E + + ++ +E+ T + EQ+ H
Sbjct: 1022 GVVTMTSR-----GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLP 1076
Query: 802 SIEAKSK------------DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE 849
S+ +S ++ VL++E +D++LQ Q + + S ++ E +E
Sbjct: 1077 SVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYME 1136
Query: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFS 909
E+ + + S EEL A +K E+ K+ QL L+ + ET + + +
Sbjct: 1137 N-EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET------GDEGKPLHLLIG 1189
Query: 910 MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSG--LKQNYDEMS 967
+K V E + L L E A K +V +++ +SG + +N D
Sbjct: 1190 KLQKAVS-EECSYFLQTLCSVLGEYYT------PALKCEVNAEDKENSGDYISENEDPEL 1242
Query: 968 PAGQISKEELQHEF-DLLKKENEQRKRKLQAALINRKELLQRVSRL-EEELANLKDE-SK 1024
+ ++ Q LL K E+ + L L R+S++ ++ +K E +
Sbjct: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLL--------VLQTRLSKIWGQQTDGMKLEFGE 1294
Query: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084
+ +P ETE + N E + SK ++ K + E+ EL+ + L+++L
Sbjct: 1295 ENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQL 1354
Query: 1085 AAEEQ-FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
EQ ++A + + + LQ + ++ + + + +IT + + VK+
Sbjct: 1355 KETEQNYEAEIHCLQKRLQ------AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKK 1408
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEKE-KEQLQKKLQEALTSRKAILKKAQEKERHL- 1201
I S E E + LEK+ +EQL++++ + + S + E R
Sbjct: 1409 N--IDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
Query: 1202 -REELKQQKDDYNRLQEQ---FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257
+E K + Q++ F+E + IG Q E++D K
Sbjct: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-------FQTFETVDVKFKEE------ 1513
Query: 1258 SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE 1317
+PL K +H + +L ++ D P + + S I +
Sbjct: 1514 ------FKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTI----SEEMFSKDKTFIVRQ 1563
Query: 1318 KVELELKVSS--TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
+ E+ VSS + +L E++ +++++ +Q E + + +A + + +Q+ +
Sbjct: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR-QMERQRED 1622
Query: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
QLQ E ++ L +L Q+ E VS L E+ AL Q + +E L
Sbjct: 1623 QEQLQ----EEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALK--QLSLAGREKL 1674
Query: 1436 ---IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE--SRAKQQIQRKLQAALI 1490
++ TQ + E+ +++ + E+ +KPE++ E S + +Q+ L
Sbjct: 1675 CCELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLK 1733
Query: 1491 SRKEALKENKSLQEELSL-ARGTIERLTKSLADV----ESQVSAQNKEKDTVLGRLALLQ 1545
E +K +++E + G ++R +KS + S+ A K + +
Sbjct: 1734 ILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVK---------SCVH 1784
Query: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQ 1605
EE ++ E S + + E TE ++LV+ S A TE
Sbjct: 1785 EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR-------SGFA-GTEID 1836
Query: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL-YGKLRSTEANKKETEKQL 1664
+++EL LQ+ ++ ++EA+ + +L + K+ TE +E+ +Q
Sbjct: 1837 PENEELMLNISSRLQA---------AVEKLLEAISETSSQLEHAKVTQTEL-MRESFRQK 1886
Query: 1665 QEAEQEM---EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721
QEA + + EE++E++ + +++++Q +EL + + +TL
Sbjct: 1887 QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE---------KTLFERQ 1937
Query: 1722 ASMKEE-LERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780
K + ++R++ E S + Q L +E+ + EE + L Q E ++ +E
Sbjct: 1938 IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVE------ 1991
Query: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
Q + ETE+ + + C + + ++++ +
Sbjct: 1992 ----------QQLLQETEKLMKEKLEVQ--CQAEKVRDDLQKQVKALEIDVEEQVSRF-- 2037
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
I+ +E+ L + +Q+N+ + LE + L Q ++ E + Q+E+ Q+
Sbjct: 2038 -IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI-------QK 2089
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
++++L V + + +E + ++E+ + N+ ++ TD +ELL S+ +
Sbjct: 2090 LEQQLKVVPRFQPISEHQTREVEQ------------LANHLKEKTDK--CSELLLSK-EQ 2134
Query: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ---ELLKEK 2017
L++ + E EE ++L ++E + E + + +P S +LQ + + K
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKP-ELSLEVQLQAERDAIDRK 2193
Query: 2018 QQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAEL 2077
++E+ L++ +++E++ V+ L +Q E QK T+ L + + K + ++
Sbjct: 2194 EKEITNLEEQLEQFREELENKNEEVQQLH-MQLEIQKKESTTR--LQELEQENKLFKDDM 2250
Query: 2078 ASFKVLLDDTQSEAARVLADNLKLKK--ELQSNKESVKSQMKQKDEDLERRLEQAEEKHL 2135
K+ L +S+A ++ K ++ KE Q+ ++ L+++L K
Sbjct: 2251 E--KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-----KIT 2303
Query: 2136 KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS 2195
+ K ++EK + +R + +E + + + +++E++QL E ++ +LA + S
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363
Query: 2196 SLQDDRDRVIDEAKKWERKFSDAIQSK---EEEIRLKEDNCSVLKDQLRQMSIHMEELKI 2252
+ + +EA + + I K E+++ + + +K+ L++ + M +L
Sbjct: 2364 M---NAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420
Query: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312
+ L+ +++ E D L + EL E+ E
Sbjct: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL----------------EVVLTED 2464
Query: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372
LKSL++Q T + E K NLE + Q E+ + Q + +++ +
Sbjct: 2465 ALKSLENQ-TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI---KDMQEQ 2520
Query: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIA-----ELRQQHDKEIKELENLLSQEEEENI-- 2425
E M ++KI++L EE + A+ E Q++ K ++ + + S+ E NI
Sbjct: 2521 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2580
Query: 2426 ---VLEEENKKAVD----KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
+ E+E + + ++L + + I +K Q++ K++ ++++ +
Sbjct: 2581 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVL----EKEKKLL 2636
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI------RGLRSHMDDLNSENAKLDAE 2532
+ Q+L E + EK++ E K E+ G + ++ L +E+ AE
Sbjct: 2637 ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2696
Query: 2533 LIQYR---EDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS 2589
L Y+ E L + + +K++ L + Q L KL KE E ++ +++
Sbjct: 2697 LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2756
Query: 2590 --FNALQEEKQDLSKEIES-----LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVH 2642
F L + LSK I S LK+S S T Q+ + L Q + EEV
Sbjct: 2757 CMFEPLPIK---LSKSIASQTDGTLKISSSNQTPQILVKNAGIQINL---QSECSSEEVT 2810
Query: 2643 RLSALFSSSQKRIAELE-EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETA 2701
+ + F+ +++ EL E++ ++ + ++ + ++ L + G ++ +
Sbjct: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870
Query: 2702 EER----VAELARDLVEMEQKLL-----------MVTKENKGLTAQIQSFGRSMSSLQNS 2746
+ + ELA +++ + ++G I S GR S +++
Sbjct: 2871 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF--DIASEGRGEES-ESA 2927
Query: 2747 RDHANEELDELKRKYDASLKELAQLKEQGLLNRERDAL--LSETAFSMNSTEENSLSHLE 2804
D +++ L R ++ L E + E ++ +SE N++S L+
Sbjct: 2928 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK 2987
Query: 2805 KLNQQLLSKDEQLLHLSSQLEDSYNQ-------------VQSFSKAMASLQNERD----- 2846
L ++ + E ++ SSQ +S++ ++ S +A+ + E
Sbjct: 2988 DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTT 3047
Query: 2847 ---HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK---KAMSSLQNDRDRLLKELK-- 2898
L N LE+ R E+G + AA A+ +SL +A+ + N R LK +
Sbjct: 3048 DAVGLLNCLEQ-RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQES 3106
Query: 2899 ----------NLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE------- 2941
N+QQ+ Q+ + EL +K + E Q++ + +++ EL+ E
Sbjct: 3107 EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE 3166
Query: 2942 ---NLSWQH----ELHQLRME-------------------KSSWEIHERRMKEQYLMAIS 2975
L QH EL R+E K S E+ KE+ + S
Sbjct: 3167 LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS 3226
Query: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASPDGSQNLVYETELLRTQ 3033
+ ++ L++L L S + L ++ Q+Q E+ + SQ ++Y+ +L Q
Sbjct: 3227 E-ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE-SQRMLYDAQLSEEQ 3284
Query: 3034 -LNDSLKEIHQKE-LRIQQLNSNFSQLLEEKNTLSIQLCD-TSQS---------LRENQQ 3081
N L+ + + E +RI++++S + E + +Q D T QS L+E Q+
Sbjct: 3285 GRNLELQVLLESEKVRIREMSSTLDR--ERELHAQLQSSDGTGQSRPPLPSEDLLKELQK 3342
Query: 3082 HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQ 3141
+ H ++E + E + L+ ++ VHRK+ L+ Q++ +E Q+
Sbjct: 3343 QLEE--KHSRIVE-LLNETEKYKLDSLQTRQQMEKDRQVHRKT----LQTEQEANTEGQK 3395
Query: 3142 QLCNTRQEVNELRKLLEEERDQ 3163
++ + +V +L++ LEE+R Q
Sbjct: 3396 KMHELQSKVEDLQRQLEEKRQQ 3417
Score = 227 bits (578), Expect = 2e-58
Identities = 599/2999 (19%), Positives = 1240/2999 (41%), Gaps = 397/2999 (13%)
Query: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ---LQQKDEALQEERKAA 89
E+ ++ E + +E+L +++L +L + ++QK + L ++ ++L++E++
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990
Query: 90 DNKIKKLKL---HAKAK-LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145
+ ++L++ H +A+ + S + + + G V T +E +SK +KS EE
Sbjct: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLL--DGVVTMTSRGAEGSVSKVNKSFGEESKI 1048
Query: 146 IEKIKHKLQ--------EKEELISTLQAQLTQA---QAEQPAQSSTEMEEFVMMKQQLQE 194
+ + K + ++E+LI +T+ +A QP+++ +E ++K + +
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
Query: 195 KEEFISTLQAQLS---QTQAEQAAQQVVREKDARF----ETQVRLHEDEL--LQLVTQAD 245
+ + LS T +Q + + EKD E + E+++ LQ + Q +
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168
Query: 246 VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305
++T Q+ + L L+G+ Q A + Q L + E+ T
Sbjct: 1169 LQTMKTQETGDEGKPLH----LLIGKLQ---------KAVSEECSYFLQTLCSVLGEYYT 1215
Query: 306 --LRNTVETEREESK--ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
L+ V E +E+ + E + E+ + + + QE MH LL + + L++
Sbjct: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQT 1275
Query: 362 RYSAL--EQKHKAEMEEKTSHILSLQKTGQELQSACDALKD----QNSKL--LQD----K 409
R S + +Q ++E ++ + + S L+D SKL LQD K
Sbjct: 1276 RLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK 1335
Query: 410 NEQAVQSAQTI-----QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464
E+ VQ +++ QQL++ Q EI RL + S+++ P +
Sbjct: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL-----QAVSESTVPPSLPVDSVV 1390
Query: 465 VTEENIA-SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
+TE + ++ +N G + S E + E ++ + LLE Q + + + E
Sbjct: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSG----EFGVKEE--TNIVKLLEKQYQE-QLEEE 1443
Query: 524 VSEISI---VDIANKRSSSAEESGQDVLENTFSQKH-----KELSVLLLEMKEAQEEIAF 575
V+++ + + A + S G+ ENT S K ++ EMK +Q++I F
Sbjct: 1444 VAKVIVSMSIAFAQQTELSRISGGK---ENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500
Query: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635
+ + +E E K + E L + G++ L ++ +P
Sbjct: 1501 QTFETVDVKFKE---------EFKPLSKE----------LGEHGKEILLSNSDPHDIPE- 1540
Query: 636 EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC--HQDELERLKSQI 693
S + SEE+ D ++ + D + S+S++ Q ++++LE ++ ++
Sbjct: 1541 -----SKDCVLTISEEMFSKDKTFIVRQSIHD-EISVSSMDASRQLMLNEEQLEDMRQEL 1594
Query: 694 LELELNFHKAQEIYEK-NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752
+ +A E+ + ++ + ++ + QL EE K+ N S + + L+S+
Sbjct: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL---NRQLAQRSSIDNENLVSE 1651
Query: 753 VKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYESQTAHDN---LLTEQIHSLSIEA 805
+E ++ EL A +KQL +LA E+ R ++Q ++N + + ++
Sbjct: 1652 -RERVLLEELEA-LKQL--SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707
Query: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
K +DV E+L NE +Q + ++ + E + + SSK + +
Sbjct: 1708 KPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSA 1767
Query: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISF--SMTEKMVQLNEEKFS 923
+ + E E + + E R + + D +I+ +TE+ +L++
Sbjct: 1768 SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR 1827
Query: 924 ---LGVEIKTLKEQL--NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
G EI E+L N+ SR + A ++ +E +E SS L+ ++++ EL
Sbjct: 1828 SGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH--------AKVTQTELM 1879
Query: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
E +K+ K Q L +E L SR E+LA + LS+ E G ++
Sbjct: 1880 RE-SFRQKQEATESLKCQEEL---RERLHEESRAREQLA---------VELSKAE-GVID 1925
Query: 1039 EDKENKEYSEKCVTSKCQEIE------IYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
+ K E+ + K I+ + + E E E Q I+++ E +E +A
Sbjct: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
Query: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152
+ Q L +T ++ + E+ ++ + A + D V+E V
Sbjct: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEID----VEEQVSRFIELE 2041
Query: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDY 1212
+L ++ ALEK+ E+++K L E R+ Q++ + L ++LK
Sbjct: 2042 QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP--- 2098
Query: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLP-STDQQESCSSTPGLEEPLFKAT 1271
R Q + Q++E E + + L++ + E + K D QE LE F+
Sbjct: 2099 -RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLE---FRVR 2154
Query: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE---LELKVSST 1328
E LE L + H A + Q++A+ I+ ++ E LE ++
Sbjct: 2155 E-------LEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2207
Query: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH-- 1386
EL K+EEV QL Q LEI+ ++ + E+ E+ K + +L +A E
Sbjct: 2208 REELENKNEEVQQLHMQ-----LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDA 2262
Query: 1387 --LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE---IIEQEDLIKALHT 1441
++ + ++I +KE ++ L+ Q+++ + L KI T+ I E+ +LI+ L T
Sbjct: 2263 MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLET 2321
Query: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKS 1501
Q+E + + C + + EEI + + +++Q++L A I +K ++ + S
Sbjct: 2322 QIECLMSDQE----------CVKRNREEEIEQLNEVIEKLQQEL--ANIGQKTSMNAH-S 2368
Query: 1502 LQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLE 1561
L EE + ++ + +E QV N+E + L + ++L E+ E
Sbjct: 2369 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE 2428
Query: 1562 NQSL----SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617
+S+ S S+ +A++ L++DK E+E + + +S E Q K ++ +
Sbjct: 2429 RESVEKIQSIPENSVNVAIDHLSKDKP----ELEVVLTEDALKSLENQTYFKSFEENGK- 2483
Query: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677
S N+ +++ V A E + Y +++ + + + LQ+ ++++ E+
Sbjct: 2484 --GSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE 2541
Query: 1678 MRKFAKSKQQKILELEE------ENDRLRAEVHPAG-DTAKECMETLLSSNASMK----E 1726
A Q ++ ++E +N + +E + E L S+ S
Sbjct: 2542 KVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRIS 2601
Query: 1727 ELER--VKMEYETLSKKFQSLMSEKDSLSEEVQ--DLKHQIEGNVSKQANLEATEKHDNQ 1782
ELE V+M + +K Q ++EK+ L +E + +L+ +EGN KQ E ++
Sbjct: 2602 ELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK-KRSPQD 2660
Query: 1783 TNVTEEGTQSIPGETE-----EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837
V + T+ E E ++L + T +E + A + + +
Sbjct: 2661 VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2720
Query: 1838 YLQQIDQLKERIAGLEEEKQ--KNKEFSQTLENEKNTLLSQISTK---------DGELKM 1886
+ + Q+++ +A +E+ + ++ ++ E++K + + K DG LK+
Sbjct: 2721 LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2780
Query: 1887 LQEEVT----------KMNLLNQQIQEELS--------RVTKLKETAEEEKDDLEERLMN 1928
T ++NL ++ EE++ ++ K++E E D+E R ++
Sbjct: 2781 SSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHIS 2840
Query: 1929 QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK 1988
+ L + + +LL+ E LK + L ++ + E ++ +
Sbjct: 2841 ETETLK----------REHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTR 2890
Query: 1989 EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFV 2048
E G+ G + ++ E + E + D + +KI L R V
Sbjct: 2891 EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS--FPKKIKGLLRAV------ 2942
Query: 2049 QTESQKDLEITKENLAQAVEHRKKAQAE--LASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
E + L +T+ + +H + +E L K ++ S + L+ + E+
Sbjct: 2943 HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVY 3002
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
+ +S +S + E L ++ L+E+ + L A R E L T + L
Sbjct: 3003 DSSQSHESFSDWRGE----LLLALQQVFLEERSVL---LAAFRTELTALGTT--DAVGLL 3053
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD-DRDRVIDEAKKWERKFSDAIQSKEEE 2225
N ++ +Q+ Q + +M LQ DR ++ E + + + + + E
Sbjct: 3054 NCLEQRIQE----------QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKRE 3103
Query: 2226 IRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGE 2285
++ + +L+ ++Q M E+++ +S ++ ++ Q ++ ++ V L+ E
Sbjct: 3104 QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA----TELQEQLSSEKMVVAELKSE 3159
Query: 2286 NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQ 2345
+ +LE T H EL E+K D++ L+++L +++ L+ + ++
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3219
Query: 2346 EADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQ 2405
+A + S+ ++ DL+ S E + + ++N+ ++ LL+ ++ I+ R
Sbjct: 3220 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE----SQRML 3275
Query: 2406 HDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS 2465
+D + LS+E+ N+ L+ + + ++ TL ++ + Q ++ D +S
Sbjct: 3276 YDAQ-------LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS-DGTGQS 3327
Query: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
L ++ D + +QLEE+H I+ E E K K + R M+ +
Sbjct: 3328 RPPLPSE-DLLKELQKQLEEKHSRIV--------ELLNETEKYKLDSLQTRQQME----K 3374
Query: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
+ ++ + +Q ++ N QK++ E+Q ++E+ +LEEK ++ + + +
Sbjct: 3375 DRQVHRKTLQTEQEAN------TEGQKKMHELQ----SKVEDLQRQLEEKRQQVYKLDLE 3424
Query: 2586 LRRSFNALQE-EKQDLSKE--IESLKVSISQLTRQVT-ALQEEGTLGLYHAQL---KVKE 2638
+R +QE +KQ+L +E ES ++ L T +L + T Q + KE
Sbjct: 3425 GQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKE 3484
Query: 2639 EEVHRLSALFSSSQKRIAELE---EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695
+L + ELE ++L CV A K+ + K + L
Sbjct: 3485 SNYAKLIEMNGGGTGCNHELEMIRQKLQCV----ASKLQVLPQKASERL----------- 3529
Query: 2696 NETETAEER----VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751
+ ETA++ V E +++ QKL E L + S G L
Sbjct: 3530 -QFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELT 3588
Query: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA-FSMN---STEENSLSHLEKLN 2807
+ +L + + + +L+EQ R+ A ++ FS+N + E S E N
Sbjct: 3589 GHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWN 3648
Query: 2808 QQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL--------WNELEKFRKS 2858
++ L+ + L +++ ++++ S + +L + +H+ + E FRK+
Sbjct: 3649 REKLTLQKSLKRAEAEVYKLKAELRNDS-LLQTLSPDSEHVTLKRIYGKYLRAESFRKA 3706
Score = 121 bits (304), Expect = 1e-26
Identities = 230/1172 (19%), Positives = 497/1172 (42%), Gaps = 183/1172 (15%)
Query: 2119 KDEDLERRLEQAEEK--HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
+DE+ +++LE + K +++K + +++K + + + V+ + D + Q
Sbjct: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHH-DLNIDQS 60
Query: 2177 QEN---------LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Q N ++STV + +++ S E E+ FS ++S EI
Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHS---------GEITSHEQGFSVELES---EIS 108
Query: 2228 LKEDNCS--------VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC 2279
D+CS V++ + EE ++ S E Q + T +++ +
Sbjct: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQ----DSPTHLEMMESEL 164
Query: 2280 DTLQGENKELLSQLEETRHLYHSSQ-NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338
Q E +EL +LEE R Y + +L + E+ +K +T L+ +L++ + +K
Sbjct: 165 AGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDET 224
Query: 2339 EGIIRQQEADIQNSKFSYEQLETD---------------LQASRELTSRLHEEINMKEQK 2383
+ Q + ++QL+ LQA +++ + H++ ++
Sbjct: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT--HQQQLEEQDH 282
Query: 2384 IISLLSGKEEAIQVAIAELRQQ----HDKEIKELENLLSQE-EEENIVLEEENKKAVD-- 2436
++ K+E + I+ L+++ ++ K++EN +E +E+ ++EE N K ++
Sbjct: 283 LLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEE 342
Query: 2437 -KTNQLMETLKTIKK---ENIQQKAQLDSFVKSM-----SSLQNDRD------RIVGDYQ 2481
KT +L + L T K E +Q Q + +K+M +S Q +R +++G +
Sbjct: 343 KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402
Query: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541
+L++R+ + ++Q E + E+ LR+ +D++ + +++Q +++L
Sbjct: 403 ELQKRNHKDSQFETDIVQRMEQETQRKLEQ---LRAELDEMYGQ------QIVQMKQELI 453
Query: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601
+ Q+ E++ + E+EN + + +E+ + + + N L + QD +
Sbjct: 454 R------QHMAQMEEMKTRHKGEMENA-LRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506
Query: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661
+ E LK + + + ALQ + L +L E++ R + + ++ E +
Sbjct: 507 SQKEKLKEELGLILEEKCALQRQ--LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564
Query: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721
L V+ A+ V E + + ELKH E E ++ KL M
Sbjct: 565 LSTVEDLKAEIVSASESRKELELKH----------EAEVTNYKI------------KLEM 602
Query: 2722 VTKE-NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780
+ KE N L +S + L+ ++EE EL + LKE +++ + + +
Sbjct: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEE--ELSK-----LKEDLEIEHRINIEKL 655
Query: 2781 RDALLSETAFSMNSTEENSLSHLEKL---NQQLLSKDEQLLHLSSQLED-SYNQVQSFSK 2836
+D L ++ + +E + L++K QL+ S+L+D + V S S+
Sbjct: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715
Query: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND------- 2889
M NE L E+E R+ E+ K + + + L+K M +ND
Sbjct: 716 EMTLQINE---LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772
Query: 2890 ---RDRLLKELKNLQQQYLQINQEITE------LHPLKAQLQE--YQDKTKAFQIMQEEL 2938
+ +LK+ K + L+I+ +++ L +K++ ++ ++ + + E+L
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832
Query: 2939 RQENLSWQHELHQLR----MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994
+Q+ + E+ + R + ++E++ + ++E+Y + KD L +N +EL
Sbjct: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLEDSKNK-QELEYK 890
Query: 2995 SSQTQPLKVQYQRQASPET----SASPDGSQNLVYET-------ELLRTQLNDSLKEIHQ 3043
S + + ++ +P T S+ D + V ET E T+L + L+ +
Sbjct: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950
Query: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG-------DLLNHCAVLEKQ 3096
++L + Q S+ S+ L++K+ L + +SL++ ++ ++NH Q
Sbjct: 951 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010
Query: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156
+ Q L V + G + + +SF E + + + + +
Sbjct: 1011 SCDTQVSSLLDGVVTMTSRGAEG--------SVSKVNKSFGEESKIMVEDKVSFENM-TV 1061
Query: 3157 LEEERDQRVAAENALSVAEE-QIRRLEHSEWD 3187
EE + +++ ++ SV +E +R + SE D
Sbjct: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSEND 1093
Score = 75.1 bits (183), Expect = 1e-12
Identities = 119/591 (20%), Positives = 239/591 (40%), Gaps = 64/591 (10%)
Query: 23 DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82
+ N++ L + ++ ++QE+L+ + +V ELK + Q ++L+ +A
Sbjct: 3115 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3174
Query: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
+ K +++ +L K K ++ + + ++ + E++ +K +S +
Sbjct: 3175 HKHLK----ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3230
Query: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
+ E+E +K L+ +++ LQ L Q +Q S + E M Q EE L
Sbjct: 3231 KEELEDLKFSLESQKQ--RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3288
Query: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHED-ELLQLVTQADVETEMQQKLRVLQRKL 261
+ Q+ ++ + +RE + + + LH + Q+ + L+ LQ++L
Sbjct: 3289 ELQV----LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3344
Query: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
EE +++V+LL + E+ Q QQME + R T++TE+E +
Sbjct: 3345 EEK------HSRIVELLNE----TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN---- 3390
Query: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE------QKHKAEME 375
E + H LQ ++ L Q E+ Q +L+ L+ QK + E E
Sbjct: 3391 -------TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443
Query: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE----------- 424
EK L + E + + +LQ K E + + + +E
Sbjct: 3444 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHE 3503
Query: 425 -DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483
+ ++QK + ++ L LP + E + D Q +E I LQK + + E
Sbjct: 3504 LEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQK-LTGQQGE 3562
Query: 484 KGALLLSSIE----LEELKAENEKLSSQITLL-----EAQNRTGEADREVSEISIVDIAN 534
+ +L+ S E L +N +L+ I+ L + +N + + ++
Sbjct: 3563 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGR 3622
Query: 535 KRSSSAEESGQDVLENTFSQK----HKELSVLLLEMKEAQEEIAFLKLQLQ 581
SS +G +E + + ++E L +K A+ E+ LK +L+
Sbjct: 3623 DNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELR 3673
Score = 33.9 bits (76), Expect = 2.7
Identities = 64/324 (19%), Positives = 124/324 (38%), Gaps = 56/324 (17%)
Query: 20 DDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK- 78
++T++ L E D + + T + QE ++ + EL+ + QL++K
Sbjct: 3356 NETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKR 3415
Query: 79 ---------------------DEALQEERKAADNKIKKLKLHAKA--KLTS--LNKYIEE 113
+ L+ E K +I L+ LTS ++ +
Sbjct: 3416 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQ 3475
Query: 114 MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173
K +G T+ + +L + + T E+E I+ KLQ +++ L Q +E
Sbjct: 3476 QKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ----CVASKLQVLPQKASE 3527
Query: 174 QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH 233
+ + + E+F+ +++ + +E I LQ +L+ Q E+ + ++
Sbjct: 3528 RLQFETADDEDFIWVQENI---DEIILQLQ-KLTGQQGEEPSLVSPSTSCGSLTERLLRQ 3583
Query: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEH---------------EESLVGRAQVVDLL 278
EL ++Q TE + LR + KLEE SL G A + ++
Sbjct: 3584 NAELTGHISQL---TEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAII 3640
Query: 279 QQELTAAEQRNQILSQQLQQMEAE 302
E + L + L++ EAE
Sbjct: 3641 ASEKEVWNREKLTLQKSLKRAEAE 3664
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 296 bits (758), Expect = 2e-79
Identities = 499/2524 (19%), Positives = 1049/2524 (41%), Gaps = 266/2524 (10%)
Query: 281 ELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQE 340
+L EQ + Q + A L+N+ E ++ ++ L+ K++ +V L + + +
Sbjct: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT-LVRKLQAKV----LQYRSWCQ 71
Query: 341 EMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD 400
E+ LE + R+ +E+ + E+ + +E Q C++L +
Sbjct: 72 ELEKRLEA------TGGPIPQRWENVEEPNLDELLVRL----------EEEQQRCESLAE 115
Query: 401 QNSKL-LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYN 459
N++L L + V A L + +++ + + S+ + L ++ + + F Y
Sbjct: 116 VNTQLRLHMEKADVVNKA-----LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYL 170
Query: 460 EGTQAVTEENIASLQKRVVELENE----KGALLLSSIELEELKAENEKLSSQITLLEAQN 515
+G + SL + VV K A + +L ELKAE+ +LS + +
Sbjct: 171 KGEHG----RLLSLWREVVTFRRHFLEMKSA---TDRDLMELKAEHVRLSGSLLTCCLRL 223
Query: 516 RTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLL----LEMKEAQE 571
G RE + +D + LE ++ +EL L LE E Q+
Sbjct: 224 TVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQD 283
Query: 572 EIAFLKLQLQGKRAEEADHEVLDQ---KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNE 628
+ L L + + D+E + + + ++ +E ++ + L Q+ L +
Sbjct: 284 RVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQ 343
Query: 629 E-SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE 687
+ V E+ Q E D+ + + QD DK+L+ V + + ++
Sbjct: 344 VIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQ 403
Query: 688 RLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERD 747
L+ Q+ + +A + ++ D+ +E L Q +++ D + L E D
Sbjct: 404 DLRQQLAGCQ----EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVD 459
Query: 748 QLLSQVKELSMVTELRAQVKQ-LEMNLAEAERQRRLDYESQTAHDNLL---TEQIHSLSI 803
L KE ++ + R +++Q LE+ EA R RR++ E Q D+ EQ L +
Sbjct: 460 SLS---KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL 516
Query: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
+ + E LQ L ++ + SE + + +L+ L ES LEG E +R ++V
Sbjct: 517 AVRER----ERLQEMLMGLEAKQSESLSELITLREAL---ESSHLEG-ELLRQEQTEVTA 568
Query: 864 LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923
Q E++ + L + D+ + ++ + + ++++QL EE S
Sbjct: 569 ALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQS 628
Query: 924 LGVEIKTLKEQLNLLS---RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHE 980
+ ++ ++ N L E ++E + E N Q +E Q ++Q E
Sbjct: 629 VCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688
Query: 981 FDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ ++K+ + + + +AA ++L Q R EE LA E KE + E EV
Sbjct: 689 KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE--KEALVREKAALEVRLQ 746
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
++ +Q ++E+ L ++ LE L F+A +Q N
Sbjct: 747 AVERD-----------------RQDLAEQLQGLSSAKELLESSL-----FEA--QQQNSV 782
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
++ Q+++ +++ + +IQ + D + +E + + + K
Sbjct: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE----KERHLREELKQQKDDYNRLQ 1216
LE++ A EKE QL++K ++ + + L KA E ++ L LK+Q+ + +Q
Sbjct: 843 ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLE----EPLFKATE 1272
Q +E+ + E+ Q++ + R S+ L T Q+E ++ LE + + +
Sbjct: 903 AQREEERTQAESALCQMQLETEKERVSLLETLLQT-QKELADASQQLERLRQDMKVQKLK 961
Query: 1273 QHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL 1332
+ T +L++ L E +A Q +A ++ + + +K++L+ +V S+L
Sbjct: 962 EQETTGILQTQLQEAQRELKE--AARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL 1019
Query: 1333 TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL-Q 1391
+ + +++++ ++ E + + E E SL L + ++ L+ + Q
Sbjct: 1020 VAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079
Query: 1392 PKLDELQKLISKKEEDVSYLSGQLS-------EKEAALTKIQTEIIEQEDLIKALHTQLE 1444
+L L++ + + + + LS Q+ EKEA + +++E+ + QL
Sbjct: 1080 QELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLR 1139
Query: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
+ + QLQ+ L + + E + E + Q Q + Q A SL
Sbjct: 1140 ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA------------SLYS 1187
Query: 1505 ELSLARGTI-ERLTKSLADVESQVSAQNKEKDTVLGR---------LALLQEERDKLITE 1554
L A G++ E + +S S E D R AL E + +
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 1555 MDRSLLENQS----LSSSCESLKLALEGLTEDKEKLVKEIESLK---SSKIAESTEWQEK 1607
+ + L + Q L + L+ L +K ++ E++ L+ S E ++W+ K
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 1608 HKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
L+ E L++ +E +++ R++ E R E Q L++ + N + LQ A
Sbjct: 1308 QNSLESE---LMELHETMASLQSRLRRA-ELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Query: 1668 EQEMEE-------MKEKMRKFAKSKQQKILELEEENDRLRA-----EVHPA-GDTAKECM 1714
E ++E +R + + K E+E E +R +A E+ A G +E +
Sbjct: 1364 VVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENL 1423
Query: 1715 ETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLE 1774
L + A +EE+E ++ + + L K+ + + + LS +++ +++ +Q ++
Sbjct: 1424 ALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD---LQQEQIQ 1480
Query: 1775 ATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
EK + +P +E++ R E ++ + ++
Sbjct: 1481 ELEK-------CRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK 1533
Query: 1835 INNYLQ----QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEE 1890
+ ++ Q+ LK+++ LE + +E +E ++ + ++ + L
Sbjct: 1534 KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHL 1593
Query: 1891 VTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIK 1950
+ +Q++Q + S++ L+ + +L+ER + + + + + + Q +
Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQER--------DQEVKSQREQIEELQRQ 1645
Query: 1951 NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010
E L +++ + + L++E+ Q+++++ +++I +E LE+I+ + +E G + +
Sbjct: 1646 KEHLTQDLERRDQELM-LQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQ-- 1702
Query: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE-- 2068
++L++E+ +E K K E + + R + Q E +L+ K+ L Q ++
Sbjct: 1703 RQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL 1762
Query: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE--------LQSNKESVKSQMKQKD 2120
HRK + L LL + E VL L+ +E LQS + + + Q+D
Sbjct: 1763 HRKVGETSL-----LLSQREQEIV-VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD 1816
Query: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180
++LE L+Q +++ +++ ++EK DAL+ T+ E L ++ ++L+E L
Sbjct: 1817 QELEA-LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEEL 1875
Query: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
++ A + + L+ + +++ ++ Q E E R +D+ + L
Sbjct: 1876 AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVL 1935
Query: 2241 RQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLY 2300
++ +E L+ H ++ ++A+ + K LQG+ + LL Q E +R
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSR--- 1992
Query: 2301 HSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLE 2360
SL+ L SL+ C+ LE +R QE +IQ+ Y++
Sbjct: 1993 ---------------SLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE-- 2035
Query: 2361 TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE----------- 2409
D+Q ++ ++ EE+ ++++ L + +Q + + +Q +E
Sbjct: 2036 -DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQ 2094
Query: 2410 -IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSS 2468
++EL+ L+Q+E+E + L E ++ + L + KT E +Q +LDS
Sbjct: 2095 SVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSPME--EQSLKLDSLEPR--- 2147
Query: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQL---IQEAAAENNKLKEEIRGLRSHMDDLNSE 2525
LQ + +R+ +Q E R + + L + + A + L+E L++ + + +SE
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207
Query: 2526 NAKLDAELIQYREDLNQV------------ITIKDSQQKQLLEVQLQQNKELENKYAKLE 2573
+L EL R L + + + Q QL EV + + + K
Sbjct: 2208 QQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267
Query: 2574 --EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631
++L+ ++A L + LQ L +E ++ +L R+ + G+L +
Sbjct: 2268 WRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISK 2327
Query: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED------KLKKELK 2685
A ++ R +S K +AEL++E+V +Q + + + +D + +EL
Sbjct: 2328 ATASSPTQQDGRGQK--NSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELA 2385
Query: 2686 HLHH 2689
LHH
Sbjct: 2386 GLHH 2389
Score = 265 bits (676), Expect = 7e-70
Identities = 462/2279 (20%), Positives = 962/2279 (42%), Gaps = 326/2279 (14%)
Query: 1083 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142
+L EEQ AL +QM + ++ Q E + QA + + + + L K
Sbjct: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQ-EAQQRQATLVRKLQAKVLQYRSWCQELEK 75
Query: 1143 ETVVISPPCTGSSEHWK-PELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL 1201
P E+ + P L+E ++ LE+E+++ + L E T + ++KA + L
Sbjct: 76 RLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCES-LAEVNTQLRLHMEKADVVNKAL 134
Query: 1202 REELKQQKDDYNRLQE---------QFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD 1252
RE++++ D++R ++ Q +++ + G+ R L + RE + T
Sbjct: 135 REDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW-REVV------TF 187
Query: 1253 QQESCSSTPGLEEPLFKATEQHHTQPVLESNLC----PDWPSHSEDASALQGGTSVAQI- 1307
++ + L + +H C S + S G AQ+
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 1308 ----KAQLKEIEA----------------EKVELELKVSSTTSELTKKSEEVFQLQEQIN 1347
K Q E EA EK EL+ +V+ ++ LT+ ++ ++ I
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIK 307
Query: 1348 KQGLEIESLKT-----VSHEAEVHAESLQQKLESSQL----------------QIAGLEH 1386
+E L+T + HEA + + ++KL Q+ Q +G E+
Sbjct: 308 ALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHEN 367
Query: 1387 LRELQPK-------------LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQE 1433
EL L ++ +++++ + V L QL+ + A+ +Q + + E
Sbjct: 368 SLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWE 427
Query: 1434 DLIKALHTQLEMQAKEHDERIKQ-----------------LQVELCEMKQKPEEIGEESR 1476
+ KAL +L+ E D Q LQ E++Q+ E + +E+
Sbjct: 428 EEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAW 487
Query: 1477 AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
+++ +LQ + A + + QEEL LA ERL + L +E++ S E T
Sbjct: 488 RLRRVNVELQ---LQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELIT 544
Query: 1537 VLGRLA-------LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
+ L LL++E+ ++ + R+ LSSS +LK + L KL
Sbjct: 545 LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL 604
Query: 1590 IESLKSSKIA---ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL 1646
E+L K+ + + +E+++ + E Q+ + + + EA+ ++ L
Sbjct: 605 NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL 664
Query: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
+L+ E E + L++ ++E EE+++K+ + ++ +LE+ + + +
Sbjct: 665 EAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVL 724
Query: 1707 GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGN 1766
+E E L+ A+++ L+ V+ + + L+++ Q L S K+ L + + + Q
Sbjct: 725 ARAVQE-KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 1767 VSKQANLEATEKHDNQTNVTEEG-TQSIPGETEEQDSLSMSTRPTCSESVPSAKS-ANPA 1824
+ LE + Q +G + + E + + S + R + + A+ A
Sbjct: 784 EVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTA 843
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGEL 1884
+ + ++H++ +++QL+E+ +E +E ++ LE+ + + EL
Sbjct: 844 LEQQKAAHEK------EVNQLREKWE--KERSWHQQELAKALES--------LEREKMEL 887
Query: 1885 KM-LQEEVTKMNLLNQQIQEEL----SRVTKLKETAEEEKDDLEERLMN---QLAELNGS 1936
+M L+E+ T+M + Q +EE S + +++ E+E+ L E L+ +LA+ +
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 1937 IGNYCQDVTDAQIKNE----LLESEMKNLKKCVSE-----------LEEEKQQLVKEKTK 1981
+ QD+ ++K + +L+++++ ++ + E L+EE L+++K
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD 1007
Query: 1982 VESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKI--SALE 2039
++ ++ K Q ++ + +E+QE L+E Q E ++QK+ R + + S +E
Sbjct: 1008 LQKQVEDL---KSQLVAQDDSQRLVEQEVQEKLRETQ-EYNRIQKELEREKASLTLSLME 1063
Query: 2040 RTVKALEFVQTES--QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLAD 2097
+ + L + +S Q++L ++++ +A +K+ A++ ++L + + + A LA
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM---ELLRQEVKEKEADFLAQ 1120
Query: 2098 NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE 2157
+L +EL+++ + Q++ E + Q + + ++ + +L+AL E+ +
Sbjct: 1121 EAQLLEELEAS-HITEQQLRASLWAQEAKAAQLQLR----LRSTESQLEALAAEQQPGNQ 1175
Query: 2158 TIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSS---LQDDRDRVIDEAKKWE-- 2212
+ Q L +QQ ++ + +L+ S S L+ D++ K+
Sbjct: 1176 A--QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233
Query: 2213 -----RKFSDAIQSKEEEIRLKEDNCSVLKDQLR--------------QMSIHMEELKIN 2253
+ A+ +++ + VL+DQ++ Q+ +++L+
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293
Query: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313
+S+ + +K WE K + ++ +T+ L S+L +Q E L++
Sbjct: 1294 LSQNQEEKSKWEGKQNSLESELMELHETMAS----LQSRLRRAELQRMEAQGERELLQAA 1349
Query: 2314 LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRL 2373
++L Q+ L ++ + + Q + GI+ E D++ ++ + + ++++ RE L
Sbjct: 1350 KENLTAQVEHLQAAVVEARAQ-ASAAGIL---EEDLRTARSALKLKNEEVESERERAQAL 1405
Query: 2374 HEEINMKEQK----------IISLLSGKEEAIQVA---IAELRQQHD--KEIKELENLLS 2418
E+ +K + + L+ +EE ++ I EL +Q + K EL +L
Sbjct: 1406 QEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDL 1465
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRD--RI 2476
++ + + L++E + ++K ++E L +E +QK + + + L+ DR+ R
Sbjct: 1466 KKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER-EQKLTVQR--EQIRELEKDRETQRN 1522
Query: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAE--LI 2534
V ++Q LE + +KDQ+I+ + LK+++ L +L + K++ + LI
Sbjct: 1523 VLEHQLLE------LEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLI 1576
Query: 2535 QYREDLNQV-------ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR 2587
+ E + +T+ ++ Q L+ Q Q +LE+ L +L+E ++ + R
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636
Query: 2588 RSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL 2647
LQ +K+ L++++E + ++ L+++ T Q K+ EE++ ++
Sbjct: 1637 EQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT-----RQTKILEEDLEQIKL- 1690
Query: 2648 FSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAE 2707
S ++R EL + +Q+ A + G + + + L+H+ E E +E + E
Sbjct: 1691 --SLRERGRELTTQRQLMQERAEEGKGPSKAQ-RGSLEHMKLILRDKEKEVECQQEHIHE 1747
Query: 2708 LARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKE 2767
L ++EQ+L +GL ++ +S + ++L E + E
Sbjct: 1748 LQELKDQLEQQL-------QGLHRKVGETSLLLSQREQEIVVLQQQLQEAR--------E 1792
Query: 2768 LAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
+LKEQ L ++ +A + A + E L L++ QQ ++E++ + L+ +
Sbjct: 1793 QGELKEQSLQSQLDEA---QRALAQRDQE---LEALQQEQQQAQGQEERVKEKADALQGA 1846
Query: 2828 YNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQ 2887
Q A +L+ L + E+ R+ EE + + VQ+L++ + L+
Sbjct: 1847 LEQ------AHMTLKERHGELQDHKEQARRLEE-------ELAVEGRRVQALEEVLGDLR 1893
Query: 2888 NDRDRLLKELKNLQQQYLQINQEI-TELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQ 2946
+ K L LQQQ + QE E L+ + Q K E LR E+ S +
Sbjct: 1894 AESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSR 1953
Query: 2947 HELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006
H+ R + + E K A+ K+Q L L R L +S++ Q
Sbjct: 1954 HQEEAARARAEA--LQEALGKAH--AALQGKEQHLLEQAELSRSLEASTATLQ------- 2002
Query: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLS 3066
AS D Q + L L EI ++LR Q+ Q L +++
Sbjct: 2003 --------ASLDACQA---HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRD--- 2048
Query: 3067 IQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDP 3126
+ LR Q+ +LEK + + V QEK + ++ +
Sbjct: 2049 -------EELRHQQERE-------QLLEKSLAQR--------VQENMIQEKQNLGQEREE 2086
Query: 3127 EELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185
EE+R QS E Q L QE+ ELR+ + + + + S EEQ +L+ E
Sbjct: 2087 EEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE 2145
Score = 252 bits (643), Expect = 5e-66
Identities = 487/2307 (21%), Positives = 918/2307 (39%), Gaps = 325/2307 (14%)
Query: 212 EQAAQQVVREKDARFETQVRLHEDELLQLVTQADVE--------TEMQQKLRVLQRKLEE 263
E A ++ K E + EL+QL +Q D+E TE+ L Q++ E+
Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
Query: 264 HEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQ-----------------MEAEHNTL 306
+E+ + + V++L+ T + LS+ Q+ E ++
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 307 RNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSAL 366
+ E E + + + + A++ L+ ++ + + + Q A + + L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTL--VRSVLTRRRQAVQDLRQQLAGCQEAVNLL 419
Query: 367 EQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ 426
+Q+H EE +L++ Q+L D L Q LQ + + + + +Q+ ++
Sbjct: 420 QQQHDQWEEEGK----ALRQRLQKLTGERDTLAGQTVD-LQGEVDSLSKERELLQKAREE 474
Query: 427 LQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGA 486
L+Q+ + + Q RL E Q + Q EE L V E E+
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQ-------GDSAQGQKEEQQEELHLAV--RERERLQ 525
Query: 487 LLLSSIELEELKAENEKLSSQITL---LEAQNRTGEADREVSEISIVDIANKRSSSAEES 543
+L +E + ++E LS ITL LE+ + GE R+ +A S AE S
Sbjct: 526 EMLMGLEAK----QSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 544 GQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEG 603
ENT + +L +++ E +A K+ G + E +Q +ME
Sbjct: 582 SS---ENTLKTEVADLRAAAVKLSALNEALALDKV---GLNQQLLQLEEENQSVCSRMEA 635
Query: 604 EGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKS 663
A ++V L + E A+ ++ E Q + +EE AG EL++
Sbjct: 636 AEQARNALQVDLAEA----------EKRREALWEKNTHLEAQLQKAEE-----AGAELQA 680
Query: 664 -------TKQDGDKSLS--------AVPDIGQCHQD-------------ELERLKSQILE 695
K++ K LS A + Q HQ+ E E L +
Sbjct: 681 DLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA 740
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS---EERDQLLSQ 752
LE+ +A E ++L E+ + +S+ +L+E A +S E + Q ++Q
Sbjct: 741 LEVRL-QAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQ 799
Query: 753 VKE----------LSMVTELRAQVKQ----LEMNLAEAERQRRLDYESQTA--------- 789
KE L + TE R+Q +Q LA+AE++ + E Q A
Sbjct: 800 AKEVIQGEVRCLKLELDTE-RSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
Query: 790 ----------HDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ 839
H L + + SL E +++++ Q E++ +Q Q E+ T S Q
Sbjct: 859 REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQ 918
Query: 840 LQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEK 899
+Q + + E + + +EL+ A Q E M L+++ LQ ++E
Sbjct: 919 MQLETEK--ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEA 976
Query: 900 DQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE---VS 956
+++ E + + + L EE SL L+++++L + E+ K + V +D+ V
Sbjct: 977 QRELKEAARQHRDDLAALQEESSSL------LQDKMDLQKQVEDLKSQLVAQDDSQRLVE 1030
Query: 957 SGLKQNYDEMSPAGQISKEELQHE---FDLLKKENEQRKRKLQAALINRKELLQRVSRLE 1013
+++ E +I K EL+ E L E EQR LQ A R+ Q +S L
Sbjct: 1031 QEVQEKLRETQEYNRIQK-ELEREKASLTLSLMEKEQRLLVLQEADSIRQ---QELSALR 1086
Query: 1014 EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073
+++ + E K+ E R EV+E +E + ++ +E+E
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKE----------------KEADFLAQEAQLLEELEA 1130
Query: 1074 QHI-RKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISE-NQAIIQKLITSNTD 1131
HI + L L A+E A Q+ L+ +Q++ L AE NQA Q + S
Sbjct: 1131 SHITEQQLRASLWAQE---AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYS 1187
Query: 1132 ASDGDSVALVKETVVISPPCTGSSEHWKPELEEK-ILALEKEKEQLQKKLQEALTSRKAI 1190
A ++ + +S + W E ++ +L K L EA+ S
Sbjct: 1188 ALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 1191 LKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250
L + K + R+ L +D +L+E+ + E + +L+ LQ Q+ ++ + K
Sbjct: 1248 LHQDLWKTQQTRDVL---RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKW 1304
Query: 1251 TDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE---DASALQGGTSVAQI 1307
+Q S S + E H T L+S L E + LQ +
Sbjct: 1305 EGKQNSLES---------ELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE--NL 1353
Query: 1308 KAQLKEIEAEKVE----------LELKVSSTTSELTKKSEEVFQLQEQ---INKQG-LEI 1353
AQ++ ++A VE LE + + S L K+EEV +E+ + +QG L++
Sbjct: 1354 TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKV 1413
Query: 1354 ESLKTVSHEAEVHAESL---QQKLESSQLQIAGLEHLRELQPKLDELQKL-ISKKEEDVS 1409
K + + ++L ++++E+ + QI LE RE+Q EL L + K+ ++V
Sbjct: 1414 AQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD 1473
Query: 1410 YLSGQLSEKE---AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQ 1466
Q+ E E + L + + E+E + Q+ K+ + + L+ +L E+++
Sbjct: 1474 LQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK 1533
Query: 1467 KPEEIGEESRAKQQIQRKLQAALISRKEALKEN-----------KSLQEELSLARGTIER 1515
K + I E R + Q +K L L+EN K L+ + R +
Sbjct: 1534 KDQMI-ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592
Query: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLA 1575
LT L + ++ AQ+ + + +L E + E D+ E +S E L+
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARE----LQERDQ---EVKSQREQIEELQRQ 1645
Query: 1576 LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE----ILLQSYENVSNEAER 1631
E LT+D E+ +E+ K + + K L+++ E L + ++ + +
Sbjct: 1646 KEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQL 1705
Query: 1632 IQHVVEAVRQEKQELYGKLRSTEANKKETEKQL---QEAEQEMEEMKEKMRKFAKSKQQK 1688
+Q E + + G L + ++ EK++ QE E++E+K+++ + + +K
Sbjct: 1706 MQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
Query: 1689 ILEL-------EEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKK 1741
+ E E+E L+ ++ A + + ++L S + L + E E L ++
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE 1825
Query: 1742 FQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH--------------------DN 1781
Q +++ + E+ L+ +E QA++ E+H
Sbjct: 1826 QQQAQGQEERVKEKADALQGALE-----QAHMTLKERHGELQDHKEQARRLEEELAVEGR 1880
Query: 1782 QTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQ 1841
+ EE + E+ EQ+ ++ + C+E + A+ +++LQ
Sbjct: 1881 RVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQ---------DSWLQA 1931
Query: 1842 IDQLKER---IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLN 1898
LKER + L E Q ++ + L + L+ ++ + + L+
Sbjct: 1932 QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991
Query: 1899 QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEM 1958
+ ++ + + + + LEE L Q E+ Y +DV Q + E+
Sbjct: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEEL 2051
Query: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ 2018
++ ++ LE+ Q V+E E K+ L + + ++ G +ELQ L +K+
Sbjct: 2052 RHQQEREQLLEKSLAQRVQENMIQE----KQNLGQEREEEEIRGLHQSVRELQLTLAQKE 2107
Query: 2019 QEVKQLQK-------DCIRYQEKISALERTVKALEFVQTESQKDLE----ITKENLAQAV 2067
QE+ +L++ + + + K S +E L+ ++ Q++LE ++ A+ +
Sbjct: 2108 QEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREI 2167
Query: 2068 EHRKKAQ---AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
E R+KAQ LA K + Q A + A L+ E Q Q + +L
Sbjct: 2168 EWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE---------QQRLQDELELT 2218
Query: 2125 RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG-EIQVTLNKKDKEV-QQLQENLDS 2182
RR + E H + E L + + V L E G E + + + +K+ +Q E+L
Sbjct: 2219 RRALEKERLHSPGATSTAE-LGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQ 2277
Query: 2183 TVTQL----AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKD 2238
V +L + + L+ ++V E +K +R+ A Q+ EI + +D
Sbjct: 2278 AVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQD 2337
Query: 2239 QLRQMSIH---MEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEE 2295
Q + + EL+ + L+ + + Q + + L G + L L
Sbjct: 2338 GRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSL-- 2395
Query: 2296 TRHLYHSSQNELAKLESELKSLKDQLT 2322
L + E LE+E + L + LT
Sbjct: 2396 ---LAVAQAPEATVLEAETRRLDESLT 2419
Score = 236 bits (602), Expect = 3e-61
Identities = 444/2243 (19%), Positives = 904/2243 (40%), Gaps = 315/2243 (14%)
Query: 30 LDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDE---ALQEER 86
L+ E H+ S +Q D+++ A + V EL ++ Q Q + ++ AL+E
Sbjct: 256 LEKEAHERSQELIQLKSQGDLEK--AELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
Query: 87 KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLP--TEPQSEEQLSKHDKSSTEEEM 144
+ + +L H SL++ +E K V+ T+ EE + S E +
Sbjct: 314 EILETNHTELMEHE----ASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSL 369
Query: 145 EIEK-----------------IKHKLQEKEELISTLQAQLTQAQAEQ---PAQSSTEMEE 184
E++ ++ L + + + L+ QL Q Q EE
Sbjct: 370 ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEE 429
Query: 185 FVMMKQQLQEKEEFISTLQAQLSQTQAE-----------QAAQQVVREKDARFETQV--- 230
++Q+LQ+ TL Q Q E Q A++ +R++ E +
Sbjct: 430 GKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRL 489
Query: 231 -RLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR--------AQVV------ 275
R++ + LQ + + E Q++L + R+ E +E L+G ++++
Sbjct: 490 RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL 549
Query: 276 -------DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREES---KILLEKME 325
+LL+QE T Q + ++ + NTL+ V R + L E +
Sbjct: 550 ESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609
Query: 326 LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQ 385
L+ L+EE + + E A QA+ L+ + E++ +A E+ T LQ
Sbjct: 610 LDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQ 669
Query: 386 KT---GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLP 442
K G ELQ+ ++++ ++ + +E Q QLE QL Q++K + L R
Sbjct: 670 KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE-QLHQEAKRQEEVLARAV 728
Query: 443 LQQHETASQTSFPDVYNEGTQAVTEENIASLQ-----KRVVE------------LENEKG 485
++ + + +V + + ++ LQ K ++E +E KG
Sbjct: 729 QEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
Query: 486 ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545
L ++++ + E + ++ L+ + T + E D A ++ + AE+ G+
Sbjct: 789 QL---EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER----DAAARQLAQAEQEGK 841
Query: 546 DVLENTFSQKHKELSVLL-----------LEMKEAQEEIAFLKLQLQGK-RAEEADHEVL 593
LE + KE++ L E+ +A E + K++L+ + + ++ + E +
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAI 901
Query: 594 D-QKEMKQMEGEG-IAPIKMKVFLEDTGQDFPLMPNEESSLPAVE---------KEQAST 642
Q+E ++ + E + ++++ E L+ ++ A + K Q
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK 961
Query: 643 EHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCH-------QDELERLKSQILE 695
E ++ + L +A ELK + L+A+ + Q ++E LKSQ++
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA 1021
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKN--------------------ADN- 734
+ +Q + E+ + EK +E N++ +E ++ AD+
Sbjct: 1022 QD----DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSI 1077
Query: 735 NSSAFTALSEERDQLLSQVKELSMVTEL-RAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793
+AL ++ + + KELS EL R +VK+ E + E Q + E+ +
Sbjct: 1078 RQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQ 1137
Query: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF-----SEQSTLIRSLQSQLQNKESEVL 848
L + + +A +++ +++L+ + + ++ + SL S LQ V
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC 1197
Query: 849 EGAERVRHISSKVEEL---------SQALSQKELEITKMD-----QLLLEKKRDVETLQQ 894
E + + +++L ++ +T + L + +D+ QQ
Sbjct: 1198 ESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQ 1257
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
T + QV ++ E++ EK + E++ L+ QL S+ +E K + + N
Sbjct: 1258 TRDVLRDQVQKLE----ERLTDTEAEKSQVHTELQDLQRQL---SQNQEEKSKWEGKQNS 1310
Query: 955 VSSGLKQNYDEMSPA------GQISKEELQHEFDLLKKENEQ---RKRKLQAALINRKEL 1005
+ S L + ++ M+ ++ + E Q E +LL+ E + LQAA++ +
Sbjct: 1311 LESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ 1370
Query: 1006 LQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKC-QEIEIYLKQ 1064
LEE+L + K + E+ER + +E E K K QE L Q
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGEL--KVAQGKALQENLALLTQ 1428
Query: 1065 TISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQ---AI 1121
T++E+E E++ +R ++E E +A ++ ++ L+ + ++DL Q +I E + ++
Sbjct: 1429 TLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV 1488
Query: 1122 IQKLITSNTDASDGDSVAL--VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKK 1179
++ L + + +V ++E EH ELE+K +E ++ Q+Q
Sbjct: 1489 LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL 1548
Query: 1180 LQEALTSRKAILKKAQ-----EKERHLREELKQQKDDYN----RLQEQFDEQSKENENIG 1230
++ +T L+ + E ++ L +EL+ Q++ L +E+S+E +
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 1231 DQLRQLQ----IQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCP 1286
Q+ L+ + RE + Q+E +E L + E+ + +L+
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQK---- 1664
Query: 1287 DWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ- 1345
E L+ Q Q K +E + +++L + ELT + + + + E+
Sbjct: 1665 ------ERIQVLED-----QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEG 1713
Query: 1346 ---INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402
Q +E +K + + E E Q EH+ ELQ D+L++ +
Sbjct: 1714 KGPSKAQRGSLEHMKLILRDKEKEVECQQ-------------EHIHELQELKDQLEQQLQ 1760
Query: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462
V S LS++E + +Q ++ E + + L+ Q E + Q EL
Sbjct: 1761 GLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE 1820
Query: 1463 EMKQKPEEI-GEESRAKQQIQRKLQAALISRKEALKE-NKSLQEELSLARGTIERL---- 1516
++Q+ ++ G+E R K++ LQ AL LKE + LQ+ AR E L
Sbjct: 1821 ALQQEQQQAQGQEERVKEKAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG 1879
Query: 1517 --TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
++L +V + A+++E++ L LAL Q+ + +E ++L S +
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKAL--LALQQQ----CAEQAQEHEVETRALQDSWLQAQA 1933
Query: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH 1634
L+ ++ E L E +S + + A + + L K + L +++ +AE
Sbjct: 1934 VLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAE---- 1989
Query: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
+ ++ L L + +A+ ++ E+ L+ E E+++ + ++ + QQ + + +E
Sbjct: 1990 LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE 2049
Query: 1695 E-NDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753
E + E A+ E ++ ++ + ER + E L + + L
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQ--EREEEEIRGLHQSVRELQLTLAQKE 2107
Query: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI----PGETEEQDSLSMSTRP 1809
+E+ +L+ + N NLEA H ++T+ EE + + P E + L + R
Sbjct: 2108 QEILELRETQQRN-----NLEAL-PHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
Query: 1810 TCSESVPSAKSAN------PAVSKDFSSHDEINNYLQQI------------DQLKERIAG 1851
T + + + A SS E+ +LQ D+L+
Sbjct: 2162 TEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRA 2221
Query: 1852 LEEEKQKNKEFSQTLE----NEKNTLLSQISTKDGE--------------LKMLQEEVTK 1893
LE+E+ + + T E E+ L ++S + E L+ LQ+ V +
Sbjct: 2222 LEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVAR 2281
Query: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953
+ + ++Q ++ E E E+ L+ M A GS+ T + +
Sbjct: 2282 LEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMR--AAQAGSL--EISKATASSPTQQD 2337
Query: 1954 LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
+ + KCV+EL++E L++ + +E + +++Y+ + +E H+ L
Sbjct: 2338 GRGQKNSDAKCVAELQKE-VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLL 2396
Query: 2014 LKEKQQEVKQLQKDCIRYQEKIS 2036
+ E L+ + R E ++
Sbjct: 2397 AVAQAPEATVLEAETRRLDESLT 2419
Score = 149 bits (376), Expect = 4e-35
Identities = 243/1178 (20%), Positives = 484/1178 (41%), Gaps = 193/1178 (16%)
Query: 12 VLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQ------------ 59
+L EL T+Q +RA L + + + ++ + E E LA +Q
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA 1183
Query: 60 -----LVVELKDIIRQKDVQLQQKDEA-----LQEERKAADNKIKK----LKLHAKAKLT 105
L L + + D A L+ ++ A + K+ L A+A +
Sbjct: 1184 SLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVAS 1243
Query: 106 SLNKYIEEM-KAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ 164
+L+K +++ K Q T +Q+ K ++ T+ E E ++ +LQ+ LQ
Sbjct: 1244 ALHKLHQDLWKTQ-----QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQD-------LQ 1291
Query: 165 AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE----QAAQQVVR 220
QL+Q Q E+ + ++ +L E E +++LQ++L + + + Q +++++
Sbjct: 1292 RQLSQNQEEKSKWEGKQNS----LESELMELHETMASLQSRLRRAELQRMEAQGERELLQ 1347
Query: 221 EKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQ 280
QV + +++ QA +++ LR + L+ E + + LQ+
Sbjct: 1348 AAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE 1407
Query: 281 --ELTAAE----QRN-QILSQQLQQMEAEHNTLRNTV---ETEREESKILLEKMELEVAE 330
EL A+ Q N +L+Q L + E E TLR + E +RE K LE + L++ +
Sbjct: 1408 QGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK 1467
Query: 331 RKLSFHNLQEEMHHL------LEQFEQAGQAQAE----LESRYSALEQKHKAEMEEKTSH 380
R QE++ L LE A Q + + + LE+ + +
Sbjct: 1468 RNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQ 1527
Query: 381 ILSLQKTGQELQSACDALKDQNSKL---------LQDKNEQAVQSAQTIQQLEDQLQQKS 431
+L L+K Q ++S ++D +L L++ + + + I++LE Q + +
Sbjct: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
Query: 432 KEISQFLNRLPLQQHETASQTS-FPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLS 490
++ L + E +Q+S D+ + T E LQ+R E+++++
Sbjct: 1588 VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARE-----LQERDQEVKSQRE----- 1637
Query: 491 SIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN 550
++EEL+ + E L+ + + R E + I +++ R + E + ++
Sbjct: 1638 --QIEELQRQKEHLTQDL-----ERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL 1690
Query: 551 TFSQKHKELSVLLLEMKEAQEE-----------IAFLKLQLQGKRAE-----EADHEVLD 594
+ ++ +EL+ M+E EE + +KL L+ K E E HE+ +
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
K+ + + +G+ G+ L+ E + ++++ Q E+ SL
Sbjct: 1751 LKDQLEQQLQGLH--------RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ-SL 1801
Query: 655 NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEK 714
E + D+ L A+ Q Q + ER+K + L+ +A ++ E
Sbjct: 1802 QSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861
Query: 715 AKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLA 774
+L EE A+ R Q L +V + +LRA+ ++ E L
Sbjct: 1862 QDHKEQARRLEEEL------------AVEGRRVQALEEV-----LGDLRAESREQEKALL 1904
Query: 775 EAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIR 834
++Q + L + K +D ++E L+ E + Q
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964
Query: 835 SLQ-------SQLQNKESEVLEGAERVRHISSKV--------------EELSQALSQKEL 873
+LQ + LQ KE +LE AE R + + +L +AL +E
Sbjct: 1965 ALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEG 2024
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
EI D L + DV+ LQQ + ++D+++ ++ QL E+ + V+ ++E
Sbjct: 2025 EIQDQD---LRYQEDVQQLQQALAQRDEELRH-----QQEREQLLEKSLAQRVQENMIQE 2076
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993
+ NL +E ++E++ GL Q+ E+ Q++ Q E ++L+ Q++
Sbjct: 2077 KQNL---GQEREEEEIR-------GLHQSVREL----QLTL--AQKEQEILELRETQQRN 2120
Query: 994 KLQAALINRK-----ELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYS- 1047
L+A + K E ++ LE L ++ + + L +TE E+E ++ ++ +
Sbjct: 2121 NLEALPHSHKTSPMEEQSLKLDSLEPRLQ--RELERLQAALRQTEAREIEWREKAQDLAL 2178
Query: 1048 ----EKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLE 1081
K S QE+ ++L+ ++ E++ E Q ++ +LE
Sbjct: 2179 SLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216
Score = 138 bits (347), Expect = 1e-31
Identities = 243/1129 (21%), Positives = 481/1129 (42%), Gaps = 156/1129 (13%)
Query: 2148 LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207
L + + L++ + E Q +K K Q+ Q+ + V +L A S + ++ ++
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 2208 A-----KKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262
++WE + + ++ C L + Q+ +HME+ + L D +
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVE 139
Query: 2263 ---IWESKAQTEV-------QLQQKVC-DTLQGENKELLSQLEETRHLYHSSQNELAKLE 2311
+ S+A+ E+ Q++Q+ L+GE+ LLS E + +
Sbjct: 140 KLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATD 199
Query: 2312 SELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTS 2371
+L LK + LS SL C L + Q + S + L T
Sbjct: 200 RDLMELKAEHVRLSGSLLTC-----CLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254
Query: 2372 RLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEEN 2431
L +E + + Q++I L S + + AEL+ + + EL LL+Q +++N E+
Sbjct: 255 ELEKEAHERSQELIQLKSQGD----LEKAELQDR----VTELSALLTQSQKQN----EDY 302
Query: 2432 KKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSII 2491
+K + + +E L+T E ++ +A L +N ++ + Q +++ ++
Sbjct: 303 EKMIKALRETVEILETNHTELMEHEASLS---------RNAQEEKLSLQQVIKDITQVMV 353
Query: 2492 LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENA-KLDAELIQYREDLNQVITIKDSQ 2550
E D + Q + EN+ E + S D +++ A L ++ R Q + + +
Sbjct: 354 EEGDNIAQGSGHENS--LELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAG 411
Query: 2551 QKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVS 2610
++ + + QQ+ + E + L ++L++ + L LQ E LSKE E L+ +
Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKA 471
Query: 2611 ISQLTRQVTALQEEG-TLGLYHAQLKV--------KEEEVHRLSALFSSSQKRIAELEEE 2661
+L +Q+ L++E L + +L++ KEE+ L ++ L+E
Sbjct: 472 REELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERER----LQEM 527
Query: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNE------------------------ 2697
L+ ++ + ++ + E+ L++ L+ H + ++R E
Sbjct: 528 LMGLEAKQSESLSEL-ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENT 586
Query: 2698 --TETAEERVA---------ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS 2746
TE A+ R A LA D V + Q+LL + +EN+ + +++++ ++ ++LQ
Sbjct: 587 LKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD 646
Query: 2747 RDHANEELDELKRKYDASLKELAQLKEQGL--------LNRERDALLSETAFSMNSTEEN 2798
A + + L K +L + +E G + E++ + + + S + +E
Sbjct: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ-QEA 705
Query: 2799 SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS 2858
+ + LE+L+Q+ ++E L + E + + + +++ +R L +L+ +
Sbjct: 706 ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA 765
Query: 2859 EEGKQRS--AAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHP 2916
+E + S AQ S EV K +Q KE+ + + L++ EL
Sbjct: 766 KELLESSLFEAQQQNSVIEV---TKGQLEVQIQTVTQAKEVIQGEVRCLKL-----ELDT 817
Query: 2917 LKAQLQEYQDKTKAFQIMQEE------LRQENLSWQHELHQLRMEKSSWEIHERRMKEQY 2970
++Q ++ +D A Q+ Q E L Q+ + + E++QLR WE +++
Sbjct: 818 ERSQAEQERD-AAARQLAQAEQEGKTALEQQKAAHEKEVNQLR---EKWEKERSWHQQEL 873
Query: 2971 LMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELL 3030
A+ +++ L E+R QT+ +Q QR+ E + + + ETE
Sbjct: 874 AKALESLEREKMEL-----EMRLKEQQTEMEAIQAQRE--EERTQAESALCQMQLETEKE 926
Query: 3031 RTQLNDSL----KEIHQKELRIQQLNSNFS-QLLEEKNT---LSIQLCDTSQSLRE-NQQ 3081
R L ++L KE+ ++++L + Q L+E+ T L QL + + L+E +Q
Sbjct: 927 RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Query: 3082 HYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQ 3141
H DL A+ E+ LQ +D+ K+ + + D + L E E Q+
Sbjct: 987 HRDDL---AALQEESSSLLQD---KMDLQKQVEDLKSQLVAQDDSQRLVE-----QEVQE 1035
Query: 3142 QLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSR 3190
+L T QE N ++K LE E+ A LS+ E++ R L E DS R
Sbjct: 1036 KLRET-QEYNRIQKELEREK-----ASLTLSLMEKEQRLLVLQEADSIR 1078
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 284 bits (726), Expect = 1e-75
Identities = 460/2238 (20%), Positives = 970/2238 (43%), Gaps = 280/2238 (12%)
Query: 1003 KELLQRVS----RLEEELANLKDESKKEIPLSETERG-----EVEEDKENKEYSEKCVTS 1053
K+L Q++S +L++ LA + S P R +++E N+E + S
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGD--TQS 60
Query: 1054 KCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQA 1113
Q++++ + S R ++E L ++LV+ ++ + N++DL
Sbjct: 61 FAQKLQLRVPSVESL-------FRSPIKESLFRSSSKESLVRTSSR---ESLNRLDL--- 107
Query: 1114 EISENQAIIQKLITSNTDASD--GDSVALVKETVVIS-PPCTGSSEHWKPELEEKILA-- 1168
+ A +++A D G+S +L KE ++ S ++ + E + A
Sbjct: 108 --DSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
Query: 1169 -LEKEKEQLQKKLQEA-------LTSRKAILKKAQEKERHLREELK---QQKDDY-NRLQ 1216
L++EK++LQ L ++ + + L+ Q+ ++HL+EE ++KD Y + LQ
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ 225
Query: 1217 EQFD------EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ---ESCSSTPGLEEPL 1267
Q N ++ L QL+ Q + P +D + E +S LE
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQ 285
Query: 1268 FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSS 1327
+ Q + + + SH E + L Q + + E EK++ +L ++
Sbjct: 286 QRVKRQENLLKRCKETI----QSHKEQCTLLTSEKEALQEQLDERLQELEKIK-DLHMAE 340
Query: 1328 TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA-EVHAESLQQKLESSQLQIAGLEH 1386
T +T+ + +++ +G+ I K HE E+ E + Q + E
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 1387 LRELQPK-----LDELQKLIS---KKEEDVSYLSGQLSEKEAALTKIQTE--IIEQEDLI 1436
LRE + K +EL+K +S K EE L ++ E+ + K E I Q++L
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 1437 KALHTQLEMQAKEHDERIKQLQ-VELCEMKQKPEEIGEESRAKQ-QIQRKLQAALI-SRK 1493
+ +++ K +E+I +LQ + E+ +K +E+ ++ + ++ + Q +++ AL S+
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
Query: 1494 EALKENKSLQEELSLARGTIERLTKS-LADVESQVSAQNKEKDTVLGRLALLQEERDKLI 1552
E LK ++ +++ SLA +E K+ L + E+++ +E +T R+ L+
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELE------- 573
Query: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV---KEIESLKSSKIAESTEWQEKHK 1609
+ +++SL EN++ S ++ L E +KE V K L+S K + W EK +
Sbjct: 574 SSLEKSLQENKNQSKDL-AVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQ 632
Query: 1610 ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669
L+++Y+ ++ E+ + E + ++K+ ++ + E N+K EK L +
Sbjct: 633 VLKQQYQTEMEKLR------EKCEQEKETLLKDKEIIF-QAHIEEMNEKTLEK-LDVKQT 684
Query: 1670 EMEEMKEKMRKFAKSK---QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726
E+E + ++ + K++ ++++ L+++ D+++ E+ D K + + S E
Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE 744
Query: 1727 -ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN--LEATEKHD--- 1780
++R + + + + L+ E+D +E Q +E ++ + +A+ K D
Sbjct: 745 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ 804
Query: 1781 NQTNVTEEGTQSIPGETEE--QDSLSMST-RPTCSESVPSAKSANPAVSKDFSSHD-EIN 1836
+ + T E T++ + + Q L + T R ++ V ++ V + +H ++
Sbjct: 805 SYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQ 864
Query: 1837 NYLQQID----QLKERIAGL--------EEEKQKNKEFSQTLENEKNTLLSQISTKDGEL 1884
+ +QQ++ ++++++ L E+ ++ ++ Q L ++N +L + E+
Sbjct: 865 DLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI 924
Query: 1885 KMLQEEVT----KMNLLNQQIQEELS----RVTKLKETAEEEKDDLEERLMNQLAELNGS 1936
++L ++++ +++LN++ + + ++ K+K+ A+E ++ L+++L++Q A+L
Sbjct: 925 EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984
Query: 1937 IGNYCQDVT--DAQIKNELLESEMKN---LKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
+ N +++ + Q ++LE N + VS LE +++ ++ T+V R+E
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH---RRELN 1041
Query: 1992 EKIQGAQKEPGNKSHAKELQEL----LKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047
+ I +K+ + A+ELQE+ L+EK+QEV +L++ + + + + + + L+
Sbjct: 1042 DVISIWEKKLNQQ--AEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 2048 VQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQS 2107
+ L +E L Q H + K L+ + + + L +N L+++L
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
Query: 2108 NKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
K + + K+K +L +L+ +E+ K + ++ +L + + ++ E+ + L+
Sbjct: 1160 LK-MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLD 1218
Query: 2168 KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
K+ + L L++ +L + S ++ ++ + + + +E +
Sbjct: 1219 ICCKKTEAL---LEAKTNELINISSSKTNA------ILSRISHCQHRTTKV----KEALL 1265
Query: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEH-----DKQIWESKAQTEVQLQQKVCDTL 2282
+K S L+ QLRQ++ L I+ + H + QI KA E + +K
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQK 1325
Query: 2283 QGENKE------------LLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEK 2330
+G N++ L +L E + + EL + + E+ SL QLTDL+ L+
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385
Query: 2331 CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDL-----QASRELTSRLHEEINMKEQKII 2385
+ ++EA I + + Y++ + +L S ++ + E+I+ EQ +
Sbjct: 1386 SIS--------LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQ--V 1435
Query: 2386 SLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETL 2445
S K + QH +KEL+ I LE ++K+A +K Q+
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQ----------IQLELKSKEAYEKDEQI---- 1481
Query: 2446 KTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAEN 2505
+K+E QQ + D M ++ ++ + + + + I+E + I + E
Sbjct: 1482 NLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEI 1541
Query: 2506 NKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKEL 2565
L E ++ D + E L+Q + ++ KD++ K+ E L ++
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKE-------LVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
Query: 2566 ENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEG 2625
+ A+LE K KE E N ++ L+ + L E + + + Q A ++
Sbjct: 1595 YSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 2626 TLGLYHAQLKVKEEEVHR-----LSALFSSSQKRIAE---LEEELVCVQKEAAKKVGEIE 2677
L +Q++ KEE+ + LS L + Q+R E LEE+L V+ ++ +
Sbjct: 1655 LL----SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710
Query: 2678 DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTA------ 2731
+A +T EE+++ L R+L E E+ L V +E + +
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR 1770
Query: 2732 --------QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDA 2783
+++ Q+ H EEL+E +KY + + + KE G N +
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE-KEGGKNNIQAKQ 1829
Query: 2784 LLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843
L + T + + L Q++ D L+ ++ S + + +LQ
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ- 1888
Query: 2844 ERDHLWNELEKFRKSEEGKQRS-AAQP---STSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899
+ D E ++ E K +S QP S A+ L+ ++ + ++ +L KE+
Sbjct: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
Query: 2900 LQQQYLQINQEIT-ELHPLKAQL-QEYQDKTKAFQ---------IMQEELRQENLSWQHE 2948
LQ+ + +E EL LK + QE ++K K Q +++ +R+ N +
Sbjct: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
Query: 2949 LHQLRM---------EKSSWEIHERRMKE--QYLMAISDKDQQLSHL------------Q 2985
+L M ++ E+ E +E Q L I++KD L +
Sbjct: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068
Query: 2986 NLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLR--TQLNDS-LKE-- 3040
+ ++R +Q + L+ +YQ++ E + D + +T+L + T ++DS LKE
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Query: 3041 ----IHQKELRIQQLNSN 3054
IH E R+++ N
Sbjct: 2129 FREQIHNLEDRLKKYEKN 2146
Score = 259 bits (662), Expect = 3e-68
Identities = 452/2168 (20%), Positives = 922/2168 (42%), Gaps = 289/2168 (13%)
Query: 39 DMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ-LQQKDEALQEERKAADNKIKKLK 97
D++ + + + + + AE LV + +++ +Q L++ + +L R + +
Sbjct: 106 DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
Query: 98 L--HAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE 155
+ K KL + ++ + L E Q ++Q KH +EE + L+E
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKH----LQEEFDAS-----LEE 216
Query: 156 KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
K++ IS LQ Q++ ++KQ+L+ + L+ Q E A
Sbjct: 217 KDQYISVLQTQVS------------------LLKQRLRNGPMNVDVLKPL---PQLEPQA 255
Query: 216 QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV 275
+ +E++ + + + + T +QQ+++ + L+ +E++ +
Sbjct: 256 EVFTKEENPESDGEPVVEDG------TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
Query: 276 DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE----VAER 331
LL E A +++ Q+L++++ H + + T+ ++K L+E++E + +AE
Sbjct: 310 TLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAET 369
Query: 332 KLSFHNLQE------------------EMHHLLEQFEQAGQAQ-AELESRYSALEQ---- 368
K H E + L EQ E++ +A ELE S ++
Sbjct: 370 KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEA 429
Query: 369 --KHKAEMEEKTSHILSLQKTGQE----LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
K KAEM+E+ I +++KT +E LQ +K + +++ +E+ + Q +
Sbjct: 430 RRKLKAEMDEQ---IKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLH- 485
Query: 423 LEDQLQQKSKEISQFLN---RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVE 479
E +L +K +E+++ L R +Q + A + S + + +E++A + E
Sbjct: 486 -EKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA-----LEE 539
Query: 480 LENEKGALLLSSI-ELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538
LE +K A+L S +L +L+ E E ++I LE+ E + ++ D+A +
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSL---EKSLQENKNQSKDLAVHLEA 596
Query: 539 SAEESGQDVLENTFSQKHKELSVLLLEMKEA--QEEIAFLKLQLQGKRAEEADHEVLDQK 596
+ +++ +KHK L ++A E++ LK Q Q + E+ + +K
Sbjct: 597 EKNKHNKEI--TVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM-EKLREKCEQEK 653
Query: 597 EMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLND 656
E + E I ++ E T + + E SL + E H + EE+S+
Sbjct: 654 ETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH--KLEEELSV-- 709
Query: 657 AGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAK 716
LK + L A D + H + ++ S I E E++ + ++ + +++
Sbjct: 710 ----LKDQTDKMKQELEAKMDEQKNHHQQ--QVDSIIKEHEVSIQRTEKALKDQINQLEL 763
Query: 717 EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL-SMVTELRAQVKQLEMNLAE 775
+ ++ ++E + + +N + E Q +++ S + Q K E LA+
Sbjct: 764 LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
Query: 776 AERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRS 835
+ Q+ LD E++ LLT+Q+ +EA+ KDV ELD ++Q ++
Sbjct: 824 LQ-QKLLDLETERI---LLTKQV--AEVEAQKKDVC-----TELDAHKIQ-------VQD 865
Query: 836 LQSQLQNKESEVLEGAERVRHI-SSKVEELSQALSQKELEITKMDQLLLE----KKRDVE 890
L QL+ + SE+ + + + + SK+E+ ++ Q + + + + ++L+ +K+++E
Sbjct: 866 LMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIE 925
Query: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLN--LLSRAEEAKKEQ 948
L Q + K+ + ++ K ++ + + K ++E L LL + + KKE
Sbjct: 926 ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 949 VEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQR 1008
E+S KQ +M Q + + L E Q+++ ++R+EL
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRL--ETNQKEQIESLTEVHRRELNDV 1043
Query: 1009 VSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI-----YLK 1063
+S E++L N + E +EI + + E+++E E +K + C++ E+ +LK
Sbjct: 1044 ISIWEKKL-NQQAEELQEIHEIQLQ----EKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098
Query: 1064 QTISEKEVELQHIRKDLEEKLAA-------EEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+ +++ L +++ L++K A E + +A ++++ L + LQ ++
Sbjct: 1099 EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV 1158
Query: 1117 ENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQL 1176
E K++ + + +K T S E LE+K L +K E+L
Sbjct: 1159 E-----LKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 1177 QKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1236
+L +A+L E E + N + + + + L
Sbjct: 1214 AIQLDICCKKTEALL------EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIK 1267
Query: 1237 QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
V E ++ +L ++++ L +AT Q + ++ D S +
Sbjct: 1268 TCTVSE-LEAQLRQLTEEQNT-----LNISFQQATHQLEEKENQIKSMKADIESLVTEKE 1321
Query: 1297 ALQGGTSVAQIKAQLKE--IEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQGL 1351
ALQ Q A KE I K EL +++ T EL +K E+ L +Q+ +
Sbjct: 1322 ALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNV 1381
Query: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
++++ ++S E E SL+++ + + ++ L+ +++L K+D L K E V
Sbjct: 1382 QLQNSISLS-EKEAAISSLRKQYDEEKCEL--LDQVQDLSFKVDTLSKEKISALEQVDDW 1438
Query: 1412 SGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKE---HDERIKQLQVELCEMKQKP 1468
S + SE + K Q+ + ++ +K L QLE+++KE DE+I L+ EL + ++
Sbjct: 1439 SNKFSEWKK---KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF 1495
Query: 1469 EEI-GEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV 1527
+ + GE K ++++K K L++ ++ IE L + L + Q
Sbjct: 1496 DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLL--ENQ--SLSSSCESLKLALEGLTEDK 1583
++KE L L EE+D + E + +L ENQ S+ + E+ K LE +
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSV 1615
Query: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643
+ +E+++L+ +ES K EL+++ E + I+ + + +EK
Sbjct: 1616 KSKEEELKALEDRLESESAA---KLAELKRKAE----------QKIAAIKKQLLSQMEEK 1662
Query: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
+E Y K TE++ E +LQE E+E+ ++EK+ K +S Q + L + + A
Sbjct: 1663 EEQYKK--GTESHLSELNTKLQEREREVHILEEKL-KSVESSQSETLIVPRSAKNVAAYT 1719
Query: 1704 HPAGDTAKECME-------TLLSSNASMKEEL-ERVKMEYE-TLSKKFQSLMSEKDSL-- 1752
++ C++ ++L N + KE+L +RV E E T+S F+ ++ L
Sbjct: 1720 EQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIK 1779
Query: 1753 -----------SEEVQDLKHQIEGNVSKQANLEA--TEKHDNQTNVTEEGTQSIPGETEE 1799
+ L+ ++E K + + A EK + N+ + Q++ ++
Sbjct: 1780 LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI--QAKQNLENVFDD 1837
Query: 1800 QDSLSMSTRPTCS----------ESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERI 1849
TC + K + ++ +S E LQQ+D +
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897
Query: 1850 AGLEE---EKQKNK----EFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMN----LLN 1898
LEE EK K+ + +E + N L +++ + E + L +E+ ++ +L
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Query: 1899 QQIQEELSRVTK-----LKETAEEEKDDLEER----LMNQLAELNGSIGNYCQD------ 1943
++ Q+EL + K +E ++E++DLE + L + E N + Q+
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017
Query: 1944 --VTDAQ-IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES---------------- 1984
+ AQ ++ ELLES + + + ++ E+ L + + E
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077
Query: 1985 -----EIRKEYLEKIQGAQKEPGNKS-HAKELQELLKEKQQEVKQLQKDCIRYQEKISAL 2038
E++K+Y +K++ ++ PGN + ELQ L +K + + ++E+I L
Sbjct: 2078 QTQLEELQKKYQQKLE-QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNL 2136
Query: 2039 ERTVKALE 2046
E +K E
Sbjct: 2137 EDRLKKYE 2144
Score = 253 bits (646), Expect = 2e-66
Identities = 405/1874 (21%), Positives = 809/1874 (43%), Gaps = 249/1874 (13%)
Query: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNK 92
+L Q+ M T ++ + E L E+ + +L+ I+Q Q ++ E ++ +AA +
Sbjct: 357 QLEQDKGMVIAETKRQ-MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEE 415
Query: 93 IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ-----------------------SE 129
++K A+ + K EM Q T+ T + SE
Sbjct: 416 LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSE 475
Query: 130 EQLSK----HDKSSTEEEMEIEKIKHKLQEKEE--------LISTLQAQLTQAQAEQPAQ 177
EQ++K H+K +E E+ K KLQ +E + Q++ + E+ Q
Sbjct: 476 EQIAKLQKLHEKELARKEQELTK---KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ 532
Query: 178 SSTEMEEFVMMKQ-----------QLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD--A 224
S +EE + K+ LQ++ E T +L + + + + KD
Sbjct: 533 ESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAV 592
Query: 225 RFETQVRLHEDELLQLVTQADVETEM---------QQKLRVLQRKLEEHEESLVGRAQVV 275
E + H E+ +V + E E +KL+VL+++ + E L + +
Sbjct: 593 HLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE-- 650
Query: 276 DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSF 335
Q++ T + + I +++M + + +TE LE + E++E +
Sbjct: 651 ---QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE-------LESLSSELSEVLKAR 700
Query: 336 HNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS-HILSLQKTGQELQSA 394
H L+EE+ L +Q ++ Q ELE++ + H+ +++ H +S+Q+T +
Sbjct: 701 HKLEEELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK----- 752
Query: 395 CDALKDQNSKL---LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQ 451
ALKDQ ++L L+++++ + ++ LE +++ E+ Q +L + Q
Sbjct: 753 --ALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ------ 804
Query: 452 TSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE------NEKLS 505
S+ +E T+A EE +A LQ+++++LE E+ L E+E K + K+
Sbjct: 805 -SYQSATHEQTKAY-EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQ 862
Query: 506 SQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLE 565
Q + + + + E +++V ++ V S E G E T Q E ++L+
Sbjct: 863 VQDLMQQLEKQNSEMEQKVKSLTQV------YESKLEDGNKEQEQT-KQILVEKENMILQ 915
Query: 566 MKEAQE-EIAFLKLQLQGKRAE----EADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQ 620
M+E Q+ EI L +L K ++E + + K+ME +M+ L+
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
Query: 621 DFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQ 680
D +E A+E Q + ++ E N AG+ ++ + ++ + + +
Sbjct: 976 DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQK-EQIESLTE 1034
Query: 681 CHQDELERLKSQILELELN--FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738
H+ EL + S I E +LN + QEI+E L EK +E++ L Q I F + +
Sbjct: 1035 VHRRELNDVIS-IWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 739 FTALSEER-------DQLLSQVKELSM--------VTELRAQVKQLEMNLAEAERQRRLD 783
T L EE ++L Q+K+ S T+L+A +++LE++L ++ ++
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF- 1152
Query: 784 YESQTAHDNLLTEQ----IHSLSIEAKSKDVKIEVLQNE-------LDDVQLQFSEQSTL 832
+ Q +L E+ + L+ + K+ D + + L++ L+D L+F + S
Sbjct: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
Query: 833 IRSLQSQLQNKESEVLEGA---ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV 889
+ ++Q + K++E L A E + SSK + +S + TK+ + LL K V
Sbjct: 1213 L-AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
Query: 890 ETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF---SLGVEIKTLKEQLNLLSRAEEAKK 946
L+ + + ++ ++ S + QL E++ S+ +I++L + L + ++
Sbjct: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQ 1331
Query: 947 EQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH---EFDLLKKENEQRKRKLQAAL-INR 1002
+ E + LK+ E A + KEEL+ E L K+ +LQ ++ ++
Sbjct: 1332 QAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSE 1391
Query: 1003 KELLQRVSRLE------EELANLKDESKKEIPLSETERGEVEE-DKENKEYSEKCVTSKC 1055
KE R + E L ++D S K LS+ + +E+ D + ++SE K
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW--KKKA 1449
Query: 1056 QEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEI 1115
Q + T+ E +++L+ K+ EK +EQ L ++++Q + + D L+ E+
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEK---DEQINLLKEELDQ----QNKRFDCLKGEM 1502
Query: 1116 SENQAIIQKLITSNTDASDGDSVALVKE--------TVVISP-----------------P 1150
++++ ++K SN + A + E T+ I
Sbjct: 1503 EDDKSKMEKK-ESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561
Query: 1151 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210
+H++ EEK + KE E+ L+ + S KA L+ +++ H+ +K +++
Sbjct: 1562 LVQKLQHFQELGEEKDNRV-KEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 1211 DYNRLQEQFDEQSKEN-ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFK 1269
+ L+++ + +S + + Q +++ + ++ ++Q + L E K
Sbjct: 1621 ELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680
Query: 1270 ATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE---KVELELKVS 1326
E+ +LE L S SE + +VA Q +E +++ + E K+S
Sbjct: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQ-EEADSQGCVQKTYEEKIS 1739
Query: 1327 STTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQ--KLESSQLQIAGL 1384
LT+K ++ + + G E E +TVS E+ + ++ KLE ++ +
Sbjct: 1740 VLQRNLTEK-------EKLLQRVGQEKE--ETVSSHFEMRCQYQERLIKLEHAEAK---- 1786
Query: 1385 EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT-EIIEQ--EDLIKALHT 1441
+H E Q + LQ+ + +K + S + Q EKE IQ + +E +D+ K L
Sbjct: 1787 QH--EDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE 1844
Query: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK--EALKEN 1499
+ E+ + +++IK+L L K+ EE +K + + LQ K E L+EN
Sbjct: 1845 K-ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEEN 1903
Query: 1500 KSLQEELSLARGTI-ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558
+ + L + + + D+E +++ +EK + + LQ++ L E +
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE 1963
Query: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL 1618
L E LK + E+K K +E LK + + + + QKE E+
Sbjct: 1964 L----------EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELE 2013
Query: 1619 LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKM 1678
+ E ++ E ++E+ ++E +L K+ + + K T K+ +E ++ +E+M
Sbjct: 2014 MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEI---LDAREEEM 2070
Query: 1679 RKFAKSKQQKILELEEE-NDRLRAEVHPAGDT-------AKECMETLLSSNASMKEELER 1730
+ Q ++ EL+++ +L E +P D + +T L S++ +KE+ R
Sbjct: 2071 TAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFR 2130
Query: 1731 VKM-EYETLSKKFQ 1743
++ E KK++
Sbjct: 2131 EQIHNLEDRLKKYE 2144
Score = 223 bits (568), Expect = 2e-57
Identities = 392/1898 (20%), Positives = 809/1898 (42%), Gaps = 282/1898 (14%)
Query: 1463 EMKQKPEEI--GEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSL 1520
+M + E++ +S K+Q+ ++L+ + +L + EL A ++R K L
Sbjct: 119 DMDSEAEDLVGNSDSLNKEQLIQRLRRM----ERSLSSYRGKYSELVTAYQMLQREKKKL 174
Query: 1521 ADVESQVSAQNKEKDTVLGRLALLQEE-------RDKLITEMDRSLLENQS----LSSSC 1569
+ SQ +D L R+A L+EE + L E D SL E L +
Sbjct: 175 QGILSQ------SQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQV 228
Query: 1570 ESLKLALEG--LTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSN 1627
LK L + D K + ++E +++ E E E E +++ E +
Sbjct: 229 SLLKQRLRNGPMNVDVLKPLPQLEP--QAEVFTKEENPESDGEPVVEDGTSVKTLETLQQ 286
Query: 1628 EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK-----EKMRKFA 1682
+R +++++ ++ Q + + K+ ++QL E QE+E++K EK +
Sbjct: 287 RVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLIT 346
Query: 1683 KSKQQKIL--ELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSK 1740
+ + K L +LE++ + AE T ++ ETL MKEE E L
Sbjct: 347 QLRDAKNLIEQLEQDKGMVIAE------TKRQMHETL-----EMKEE------EIAQLRS 389
Query: 1741 KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + + ++ + L E+ + S++A E EK + TEE + + E +EQ
Sbjct: 390 RIKQMTTQGEELREQKEK---------SERAAFEELEKALSTAQKTEEARRKLKAEMDEQ 440
Query: 1801 ----DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK 1856
+ S R + + + K V K SS ++I ++ +L E+ E
Sbjct: 441 IKTIEKTSEEERISLQQELSRVKQEVVDVMKK-SSEEQI----AKLQKLHEK-----ELA 490
Query: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916
+K +E ++ L+ + Q+ L+ Q E K++ +Q QE L+ L+E
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVA---LEKSQSEYLKISQEKEQ-QESLA----LEELEL 542
Query: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVS-ELEEEKQQ- 1974
++K L E N+L +L Y + + + E E KN K ++ LE EK +
Sbjct: 543 QKKAILTES-ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKH 601
Query: 1975 -----LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDC- 2028
++ EK K E E K + + + + + + E+++L ++ +QE + L KD
Sbjct: 602 NKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKE 661
Query: 2029 IRYQEKISAL-ERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDT 2087
I +Q I + E+T++ L+ QTE LE L++ ++ R K + EL+ VL D T
Sbjct: 662 IIFQAHIEEMNEKTLEKLDVKQTE----LESLSSELSEVLKARHKLEEELS---VLKDQT 714
Query: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE---QAEEKHLKEKKNMQEK 2144
K+K+EL++ + K+ +Q+ + + + E Q EK LK++ N E
Sbjct: 715 D-----------KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL 763
Query: 2145 LDALRREKVHLEET---IGEIQVTLNKKDKEVQQLQENLD-------STVTQLAAFTKSM 2194
L L+ HL+E + ++ + + + E+QQ LD +T Q A+ + +
Sbjct: 764 L--LKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQL 821
Query: 2195 SSLQDDRDRVIDEAKKWERKFSDAIQSKEE---EIRLKEDNCSVLKDQLRQMSIHMEE-- 2249
+ LQ + E ++ ++ K++ E+ + L QL + + ME+
Sbjct: 822 AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKV 881
Query: 2250 ---LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL------LSQLEETRHLY 2300
++ S+LE + E Q V+ + + +G+ KE+ LS E++ H+
Sbjct: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHIL 941
Query: 2301 HSS-QNELAKLESELKSLKDQLTDLSNSLEK-CKEQKGNLEGIIRQQEADIQNSKFSY-- 2356
+ + + E +++ +K + ++ +L+K +Q+ L+ + ++ + +
Sbjct: 942 NEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001
Query: 2357 ---EQLETDLQASRELTSRLHEEINMKEQ----------KIISLLSGKEEAIQVAIAELR 2403
E + + + SRL E N KEQ ++ ++S E+ + EL+
Sbjct: 1002 KMLEMAQANSAGISDAVSRL--ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059
Query: 2404 QQHDKEIKELENLLSQEEEENIV--------------LEEENKKAVDKTNQLMETLKTIK 2449
+ H+ +++E E +++ +++ ++ L+EE K N+L E LK K
Sbjct: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQ-K 1118
Query: 2450 KENIQQKAQLDSFVKS-MSSLQNDRDRIVGDYQQLEER--HLSIILEKDQL-IQEAAAEN 2505
++ AQ ++ +K+ + L+ D ++ + + L+E+ L ++ E+D+ + E ++
Sbjct: 1119 SAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKL 1178
Query: 2506 NKLKEEIRGLRSH-------MDDLNSENAKLDAEL-IQY-----------REDLNQVITI 2546
EE + L+S ++D + E KL EL IQ N++I I
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINI 1238
Query: 2547 KDSQQKQLLE-VQLQQNKELENKYA---------KLEEKLKESEEANEDLRRSFNALQEE 2596
S+ +L + Q++ + K A +LE +L++ E L SF +
Sbjct: 1239 SSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ 1298
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIA 2656
++ +I+S+K I L + ALQ+EG G KE + +L S + +
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQKEG--GNQQQAASEKESCITQLKKELSENINAVT 1356
Query: 2657 ELEEELVCVQKE---AAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLV 2713
++EEL + E +K++ ++ +L+ + +A I + EE+ EL +
Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEK-CELLDQVQ 1415
Query: 2714 EMEQKLLMVTKENKGLTAQIQSFGRSMS----SLQNSRDHANEELDELKRKYDASLKELA 2769
++ K+ ++KE Q+ + S Q+ + EL+ + + KE
Sbjct: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
Query: 2770 QLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEK----LNQQLLSKDEQLLHLSSQLE 2825
+ EQ L +E ++ + E+ S +EK L +L S+ +++ L +
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 2826 DSYNQVQSFSKAMASLQNERD----HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
+++S ++ + + ++D L +L+ F++ E K V+ ++
Sbjct: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN----------RVKEAEE 1585
Query: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
+ +L+N + EL+ +++ +N + + K + + +++ L E
Sbjct: 1586 KILTLENQVYSMKAELETKKKELEHVNLSV-------------KSKEEELKALEDRLESE 1632
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL-----SHLQNLIRELRSSSS 2996
+ + EL + +K + +K+Q L + +K++Q SHL L +L+
Sbjct: 1633 SAAKLAELKRKAEQKIA------AIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
Query: 2997 QTQPL--KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSN 3054
+ L K++ + ET P ++N+ TE +++ +++++ + Q N
Sbjct: 1687 EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLT 1746
Query: 3055 FSQLL------EEKNTLSIQL---CDTSQSL-----RENQQHYG-DLLNHCAVLEKQVQE 3099
+ L E++ T+S C + L E +QH ++ H L+++++E
Sbjct: 1747 EKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH---LQEELEE 1803
Query: 3100 LQAGPLNIDVAPGAPQE--KNGVHRKSDPEELREPQQSFSEAQQQLCN-TRQEVNELRKL 3156
+ ++ VA +E KN + K + E + + Q + ++ C Q++ EL
Sbjct: 1804 -KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
Query: 3157 LEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPII 3194
L +++ L+ E+++ L+ + + T ++
Sbjct: 1863 LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL 1900
Score = 160 bits (404), Expect = 3e-38
Identities = 252/1307 (19%), Positives = 545/1307 (41%), Gaps = 188/1307 (14%)
Query: 1962 KKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEV 2021
KK ++ EE+QQL + ++ +++ S ++L E ++
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSR-----TSSFTEQLDEGTPNRESG- 56
Query: 2022 KQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFK 2081
D + +K+ +V++L + +KE+L + + +L S
Sbjct: 57 -----DTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSST 111
Query: 2082 VLLD---DTQSEAARVLADNLKLKKE-----LQSNKESVKS------------QMKQKDE 2121
D D SEA ++ ++ L KE L+ + S+ S QM Q+++
Sbjct: 112 ASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREK 171
Query: 2122 D-LERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQEN- 2179
L+ L Q+++K L+ ++E+L ++ K HL+E E +L +KD+ + LQ
Sbjct: 172 KKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQE---EFDASLEEKDQYISVLQTQV 228
Query: 2180 -------------------LDSTVTQLAAFTKSMSSLQDDRD--------RVIDEAKKWE 2212
L Q FTK + D + ++ ++
Sbjct: 229 SLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
Query: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEV 2272
++ + ++ +E I+ ++ C++L + + ++E + +++ ++K T++
Sbjct: 289 KRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQL 348
Query: 2273 QLQQKVCDTLQGENKELLSQLEETRH-LYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331
+ + + + L+ + ++++ + H + E+A+L S +K + Q +L EK
Sbjct: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKS 408
Query: 2332 K-----EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIIS 2386
+ E + L + +EA + EQ++T + S E L +E++ +Q+++
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 2387 LLSGKEEAIQVAIAELRQQHDKEI----KELENLLSQEEEENIVLEEENKKAVDKTNQLM 2442
++ E IA+L++ H+KE+ +EL L E E +E+ K A++K+
Sbjct: 469 VMKKSSEE---QIAKLQKLHEKELARKEQELTKKLQTRERE---FQEQMKVALEKSQS-- 520
Query: 2443 ETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAA 2502
E LK +++ Q+ L+ ++ + + + D QQ E + + ILE + ++++
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 2503 AENNKLKEEIRGLRSHMD-DLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQ 2561
EN K + + L H++ + N N ++ + +++ +L + +D+ + L+V QQ
Sbjct: 581 QEN---KNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQ 637
Query: 2562 NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESL-KVSISQLTRQVTA 2620
Y EKL+E E +EK+ L K+ E + + I ++
Sbjct: 638 -------YQTEMEKLREKCE-------------QEKETLLKDKEIIFQAHIEEMN----- 672
Query: 2621 LQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKL 2680
E TL +L VK+ E+ LS+ S K +LEEEL ++ + K E+E K+
Sbjct: 673 ---EKTL----EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM 725
Query: 2681 KKELKHLHHDAGIMRNETETAEERVAELARDLV-EMEQKLLMVTKENKGLTAQIQSFGRS 2739
++ H + E E + +R + +D + ++E L K K A +++
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
Query: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS 2799
+ + A+ +LD + A+ ++ +EQ
Sbjct: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ------------------------- 820
Query: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE 2859
L +L Q+LL + + + L+ Q+ + Q + + + + + L +LEK
Sbjct: 821 ---LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 2860 EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKA 2919
E K +S Q S E + + Q ++L E +N+ Q + ++ E+
Sbjct: 878 EQKVKSLTQVYESKLEDGNKE------QEQTKQILVEKENMILQMREGQKKEIEI----- 926
Query: 2920 QLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQ 2979
Q+ K + I+ EE + + + ++ +++ + + M+E + D++
Sbjct: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK-------AKEMQETLKKKLLDQEA 979
Query: 2980 QLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLK 3039
+L +EL +++ + + Q+ + A+ G + V E + + +SL
Sbjct: 980 KLK------KELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT 1033
Query: 3040 EIHQKELR--IQQLNSNFSQLLEEKNTL-SIQLCDTSQSLRENQQHYGDLLNHC--AVLE 3094
E+H++EL I +Q EE + IQL + Q + E +Q LL C +
Sbjct: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI--LLFGCEKEEMN 1091
Query: 3095 KQVQELQAGPLNIDVAPGAPQE---KNGVHRKSDPEE-------LREPQQSFSEAQQQLC 3144
K++ L+ + D QE + H S ++ L + + +++ ++
Sbjct: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 3145 NTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRT 3191
++++ EL+ L EE++ + + L +E+ + L+ S S+++
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198
Score = 152 bits (384), Expect = 5e-36
Identities = 281/1336 (21%), Positives = 556/1336 (41%), Gaps = 234/1336 (17%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK-----------DEALQEE 85
ES +E N QE ++ L E +++++++ +++ L QK +E + +
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 86 RKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEE-QLSKHDKSSTEEEM 144
K + K++K+K AK +L K + + +A+ L E ++ +LS+ +K + +
Sbjct: 949 FKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK----LKKELENTALELSQKEKQFNAKML 1004
Query: 145 EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVM----------MKQQLQE 194
E+ Q IS ++L Q EQ +S TE+ + + QQ +E
Sbjct: 1005 EMA------QANSAGISDAVSRLETNQKEQ-IESLTEVHRRELNDVISIWEKKLNQQAEE 1057
Query: 195 KEEFISTLQAQLSQTQAEQAAQQVVR---EKDARFETQVRLHEDELLQLVTQADVETEMQ 251
+E I +Q Q + + + Q+++ EK+ + L E+ + Q T +++ +++
Sbjct: 1058 LQE-IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLK 1116
Query: 252 QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQME----------A 301
QK + L + E L ++ L+ +L + + N L +QL +++ +
Sbjct: 1117 QKSAHVN-SLAQDETKLKAH---LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVS 1172
Query: 302 EHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
E + T + E + K EK + ++ L F L EE+ L+ + +A LE+
Sbjct: 1173 ELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDIC--CKKTEALLEA 1230
Query: 362 RYSALEQKHKAEMEEKTSHILSLQKTGQELQSAC-------DALKDQNSKLLQDKNEQAV 414
+ + L ++ S I Q +++ A L+ Q +L +++N +
Sbjct: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 415 QSAQTIQQLED---QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEEN-- 469
Q QLE+ Q++ +I + Q E +Q QA +E+
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQ----------QAASEKESC 1340
Query: 470 IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLL--EAQNRTGEADREVSEI 527
I L+K EL A+ L EL+E K E LS Q+T L + QN +++E +
Sbjct: 1341 ITQLKK---ELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS 1397
Query: 528 SI---------------------VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566
S+ VD +K SA E D N FS+ K+ +
Sbjct: 1398 SLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD-WSNKFSEWKKKAQSRFTQH 1456
Query: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMP 626
+ +E+ ++L+L+ K A E D ++ KE + + +K + +ED D M
Sbjct: 1457 QNTVKELQ-IQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE--MED---DKSKME 1510
Query: 627 NEESSLPAVEKEQAST-----EHQSRTSEEI-SLNDAGVELKSTKQDGD-------KSLS 673
+ES+L K Q + +H ++ + EI SLN+ LK+ Q D + L
Sbjct: 1511 KKESNLETELKSQTARIMELEDHITQKTIEIESLNEV---LKNYNQQKDIEHKELVQKLQ 1567
Query: 674 AVPDIGQCHQDELERLKSQILELELNFH--------KAQEIYEKNLDEKAKE--ISNLNQ 723
++G+ + ++ + +IL LE + K +E+ NL K+KE + L
Sbjct: 1568 HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
Query: 724 LIEEFK--KNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRR 781
+E K A+ A ++ + QLLSQ++E + + E+N ER+R
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDD---VQLQFSEQSTLIRSLQS 838
+ + ++ + Q +L + +K+V Q E D VQ + E+ I LQ
Sbjct: 1688 VHILEEKLK-SVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK---ISVLQR 1743
Query: 839 QLQNKESEVLE-GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE 897
L KE + G E+ +SS E Q ++ +++ + E + + LQ+ +E
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQ-YQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
Query: 898 EKDQQVTEISFSMTEK--------------------MVQLNEEKFSLGVEIKTLKEQLNL 937
EK+++ + I EK L E++ + + + +KE +
Sbjct: 1803 EKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
Query: 938 LSRAEEAKKEQVEE----------------DNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
L R +E + ++EE N+ + L++N +E S + + + L +
Sbjct: 1863 LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN-- 1920
Query: 982 DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK 1041
++ ++ + KL A +++L + + RL+++L L+ E ++E+ + + E + E+K
Sbjct: 1921 --MEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEK 1978
Query: 1042 ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTL 1101
+E +++E+ T L+ + ++ +LA +EQ ++ T+
Sbjct: 1979 IKQEQ---------EDLELKHNST-------LKQLMREFNTQLAQKEQ------ELEMTI 2016
Query: 1102 QDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPE 1161
++ N+ ++AE+ E+ + D D +K T + E E
Sbjct: 2017 KETINKAQEVEAELLESHQEETNQLLKKIAEKDDD----LKRTAKRYEEILDAREE---E 2069
Query: 1162 LEEKILALEKEKEQLQKK--------------------LQEALTSRKAILKKAQEKERHL 1201
+ K+ L+ + E+LQKK LQ L + ++ ++ KE+
Sbjct: 2070 MTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF 2129
Query: 1202 REELKQQKDDYNRLQE 1217
RE++ +D + ++
Sbjct: 2130 REQIHNLEDRLKKYEK 2145
Score = 90.1 bits (222), Expect = 3e-17
Identities = 142/653 (21%), Positives = 269/653 (41%), Gaps = 86/653 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
E+ D + + L+ EL ++ ++ + ++ E L LK+ +QKD+
Sbjct: 1501 EMEDDKSKMEKKESNLETELKSQTARIME--LEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 74 --QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTV--------LP 123
+L QK + QE + DN++K+ A+ K+ +L + MKA+ T L
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKE----AEEKILTLENQVYSMKAELETKKKELEHVNLS 1614
Query: 124 TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEME 183
+ + EE + D+ +E ++ ++K K ++K I+ ++ QL E+ Q E
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQK---IAAIKKQLLSQMEEKEEQYKKGTE 1671
Query: 184 EFVM-MKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVT 242
+ + +LQE+E + L+ +L ++ Q+ +V E + +
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD-----S 1726
Query: 243 QADVETEMQQKLRVLQRKLEEHEESL--VGRAQVVDLLQQ-ELTAAEQRNQILSQQLQQM 299
Q V+ ++K+ VLQR L E E+ L VG+ + + E+ Q I + +
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 300 EAEHNTLRNTVETEREE-----SKILLEKMELEVA----ERKLSFHNLQEEMHHLLEQFE 350
+ E ++ ++ E EE S I+ + +E E + K + N+ +++ L++ E
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 351 QA----GQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQ-ELQSACDALKDQNS-- 403
Q EL+S ++ H+ EMEE TS LQ Q + ++ L ++N+
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906
Query: 404 ---------KLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSF 454
KLL + Q + E + Q+ KEI + L + + E +
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL-- 1964
Query: 455 PDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ 514
++ + EE I Q+ + N L+ + + E E ++T+ E
Sbjct: 1965 -EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE---LEMTIKETI 2020
Query: 515 NRTGEADREVSE------------ISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVL 562
N+ E + E+ E I+ D KR++ E D E + K ++L
Sbjct: 2021 NKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQ 2080
Query: 563 LLEM------KEAQEE--------IAFLKLQLQGKRAEEADHEVLDQKEMKQM 601
L E+ K QEE I L+ QL K +D ++ +Q+ +Q+
Sbjct: 2081 LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQI 2133
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 279 bits (714), Expect = 3e-74
Identities = 496/2405 (20%), Positives = 1004/2405 (41%), Gaps = 384/2405 (15%)
Query: 900 DQQVTEISFSMTEKMVQ----LNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEV 955
D+ +T + F+ T K ++ +NE + + KE ++L K+Q+EE +
Sbjct: 314 DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDL--------KKQLEEVSLE 365
Query: 956 SSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEE 1015
+ D+++ +L E DLL+K ++ L L+ L L++E
Sbjct: 366 TRAQAMEKDQLA--------QLLEEKDLLQKVQNEKIENLTRMLVTSSSLT-----LQQE 412
Query: 1016 LANLKDESKKEIPLSETERGEVEEDKENKEYSEKC-----VTSKCQEIEIYLKQTISEKE 1070
L K + K+ + G++ + K N Y+++ +T+K ++ I L + I E
Sbjct: 413 L---KAKRKRRVTWC---LGKINKMK-NSNYADQFNIPTNITTKTHKLSINLLREIDESV 465
Query: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
+ + + L+ E ++ K +NQ + +++E++ +A L+
Sbjct: 466 CSESDVFSNTLDTLS-EIEWNPATKLLNQ---------ENIESELNSLRADYDNLVL--- 512
Query: 1131 DASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAI 1190
D + + KE + + K +L+E K K+ + +L +++ K +
Sbjct: 513 ---DYEQLRTEKEEMELKLK-------EKNDLDEFEALERKTKKDQEMQLIHEISNLKNL 562
Query: 1191 LKKAQEKERHLREEL-------KQQKDDYNRLQEQFDEQSKEN---------ENIGD--Q 1232
+K A+ + L EL ++++D +LQE D Q EN E+I D Q
Sbjct: 563 VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ 622
Query: 1233 LRQLQIQVRE-SIDGKLPSTD-QQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPS 1290
++Q ++D K S + E+ ++E + + + +S L
Sbjct: 623 MKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
Query: 1291 HSEDASALQGGTSVAQIKAQLKEIEAEK-----VELELKVSSTTSELTKKSEEVFQLQEQ 1345
+ LQ + L + + K +ELE K++ EL K+ EE L+E+
Sbjct: 683 QVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREE 742
Query: 1346 INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKE 1405
+ + + LK++ E E + +Q K E EL E KL S+
Sbjct: 743 V----ILLSELKSLPSEVERLRKEIQDKSE-------------ELHIITSEKDKLFSEVV 785
Query: 1406 EDVSYLSGQLSE-----KEAALTKIQTEIIEQE-DLIKALHTQLEMQAK---EHDERIKQ 1456
S + G L E + A T+ + +QE K LH E + K E +ER+ Q
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 1457 LQVELCEMKQK-PEEIG----EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1511
V L + QK +G E S Q++Q K + +E L E + L+E+L
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREV----QERLNEMEQLKEQLENRDS 901
Query: 1512 TIER-------LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLEN-- 1562
T++ +T+ L +V +EKD + LQ ERD+L +++ ++ N
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 1563 --QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST-----EWQEKHKELQKEY 1615
+ L ++ ESLK E + K K+ +E+ ++ + E+T E+Q+K + K+
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVS--RNLHMEENTGETKDEFQQKMVGIDKKQ 1019
Query: 1616 EILLQSYENVS-----NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQE 1670
++ ++ + ++ NE Q + ++ QEK EL L S A K++ + L+E +
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 1671 MEEMKEKMRKFAKS-KQQKILELEEENDRLR--AEVHPAGDTAKECMETLLSSNASMKE- 1726
E +E++R K+Q+ + +E+N ++ E+ D E E L + ++E
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 1727 --ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH----QIEGNVSKQANLEATEKHD 1780
+L V+ E + KK + + K+ L + L+H ++E N E +
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
+ V +E +S E + T ++ K A+ + + + DE+ +
Sbjct: 1200 KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVS 1259
Query: 1841 QID--------------QLKERIAGLEEEKQ---KNKEFSQTLE--NEKNTLLSQISTKD 1881
+ +L+E I L EE++ KE S+T E NE L Q +TKD
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319
Query: 1882 GE-LKMLQEEVTKMNLLNQQIQEELSRVTK-------LKETAEEEKDDLEERLMNQLAEL 1933
L ++ E ++N Q+ QEE+ +TK +KE E + D L+E + LA++
Sbjct: 1320 STTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKI 1379
Query: 1934 NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993
S Q + + NE K VSE+E+ K K+ + EI L K
Sbjct: 1380 QESQSKQEQSLNMKEKDNETT--------KIVSEMEQFKP---KDSALLRIEIEMLGLSK 1428
Query: 1994 -IQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
+Q + E KS AKE +L ++ QEV Q + D L+ +K + E+
Sbjct: 1429 RLQESHDEM--KSVAKEKDDL--QRLQEVLQSESD---------QLKENIKEIVAKHLET 1475
Query: 2053 QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESV 2112
+++L++ L K+ + + +V L + ++E + + Q E++
Sbjct: 1476 EEELKVAHCCL-------KEQEETINELRVNLSEKETEISTI-----------QKQLEAI 1517
Query: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVH---LEETIGEIQVTLNKK 2169
+++ K +++ E+ E+ ++K+ +QEK++ L++ K H + + I+ + +
Sbjct: 1518 NDKLQNKIQEI---YEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
Query: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL- 2228
+Q+ QE + + + + +LQ +RD++ + K+ K ++ + + + +++
Sbjct: 1575 TNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMT 1634
Query: 2229 -----KEDNCSV--LKDQLRQMSIHMEELK---INISRLEHDKQIWESKAQTEVQLQQKV 2278
+E C + LK+Q +++E ++ I ++++ H+ E + V
Sbjct: 1635 AVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSV 1694
Query: 2279 CDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK------------------SLKDQ 2320
+TL+ E +L L ET Q EL + LK + +
Sbjct: 1695 EETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNM 1754
Query: 2321 LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI--- 2377
DL +S + K Q ++ +R ++ + + ++L + + S + +++
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV---LEEENKKA 2434
N K Q+ I L E + + + + + K++ E+E L Q +++++ LE EN
Sbjct: 1815 NAKLQEKIQELKANEHQL-ITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL 1873
Query: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK 2494
K ++ +E +K++ KE D+ + +L+ +RD++ Q+ + R L I
Sbjct: 1874 AQKLHENLEEMKSVMKER-------DNLRRVEETLKLERDQLKESLQETKARDLEI---- 1922
Query: 2495 DQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL 2554
Q ++ A + + KE + LR + + + + + +L + +++L + I++ Q+K+L
Sbjct: 1923 QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK--KIQELQKKEL 1980
Query: 2555 LEVQLQQNKELENKYAKLEEKLKESEEA---------------NEDLRRSFNALQ---EE 2596
++++++ + +K E+LK+ EA + L S ++ +E
Sbjct: 1981 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE-----------EEVHRLS 2645
+ +L + ESLK+ Q + L+E + Q+K ++ E +
Sbjct: 2041 RDELRRIKESLKMERDQF---IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097
Query: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELK-HLHHDAGIMRNETE----- 2699
+ KR +E+++ C+ + + EIE +KEL + + + +T+
Sbjct: 2098 SRIKELLKRYSEMDDHYECLNRLSLDLEKEIE--FQKELSMRVKANLSLPYLQTKHIEKL 2155
Query: 2700 -TAEERVA-ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDEL 2757
TA +R + E R + +++ L VTK + I F + ++ L
Sbjct: 2156 FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2215
Query: 2758 KRKYDASLKELAQLKEQGLLNRERDALL---SETAFSMNSTE------------------ 2796
++ D +EL LK ++ + +L SE+ F TE
Sbjct: 2216 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEW 2275
Query: 2797 ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS----YNQVQSFSKAMASLQNERDH----L 2848
N+ +EKL + +++++ +++ + N+ F + A++ E + L
Sbjct: 2276 LNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSL 2335
Query: 2849 WNELEKFRKSEEGKQRSAA-------------QPSTSPAEVQSLKKAMSSLQNDRDRLLK 2895
+ EK K+ + + S A P + Q + + L+N +
Sbjct: 2336 KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKE 2395
Query: 2896 ELKNLQQQYLQINQEITELHPLKAQLQ-------EYQDKTK-AFQIMQEELRQENLSWQH 2947
+ + + +++ +E+ + + A+LQ + +KTK Q++Q+++ ++
Sbjct: 2396 SAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKE 2455
Query: 2948 ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS---SSQTQPLKVQ 3004
E+ L+M+ ++ + + +++ IS + + + +IR LR + S Q Q V
Sbjct: 2456 EIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSV- 2514
Query: 3005 YQRQASPETSASP---DGSQNLVYETELLRTQLNDSLKEIH-QKELRIQQLNSNFSQLLE 3060
P+ S P G +V T+ L LK H + E I +L QL++
Sbjct: 2515 ISEHTDPQPSNKPLTCGGGSGIVQNTKAL------ILKSEHIRLEKEISKLKQQNEQLIK 2568
Query: 3061 EKNTL 3065
+KN L
Sbjct: 2569 QKNEL 2573
Score = 257 bits (657), Expect = 1e-67
Identities = 481/2296 (20%), Positives = 972/2296 (42%), Gaps = 367/2296 (15%)
Query: 38 SDMEFNNTT----QEDVQERL----AYAEQLVVELKDIIRQKD-VQLQQKDEALQEERKA 88
S++E+N T QE+++ L A + LV++ + + +K+ ++L+ K++ +E +A
Sbjct: 480 SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA 539
Query: 89 ADNKIKKLK----LHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEM 144
+ K KK + +H + L +L K+ E E +LS + E+E
Sbjct: 540 LERKTKKDQEMQLIHEISNLKNLVKHAEVYNQD----------LENELSSKVELLREKED 589
Query: 145 EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQA 204
+I+K++ + ++ + + E P Q + + + + + F+ +
Sbjct: 590 QIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL 649
Query: 205 QLSQTQAEQAAQQVVREKDARFETQVRLHEDEL-LQLVTQADVETEMQQKLRVLQRKLEE 263
+L + E A E D ++L++ +L + Q D+E E+Q + KL
Sbjct: 650 ELKEKMKELATTYKQMEND------IQLYQSQLEAKKKMQVDLEKELQSAFNEIT-KLTS 702
Query: 264 HEESLVGRAQVVDL--------LQQELTAAEQRNQ------ILSQQLQQMEAEHNTLRNT 309
+ V + + +L LQ+EL + N+ IL +L+ + +E LR
Sbjct: 703 LIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKE 762
Query: 310 VETEREESKILL---EKMELEVAERKLSFHNLQEEMHHLLEQ-------FEQAGQAQAEL 359
++ + EE I+ +K+ EV ++ L EE+ + ++ Q
Sbjct: 763 IQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNF 822
Query: 360 ESRYSALEQKHKAEMEEK---TSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS 416
++ + EQK+K +EE I++L K Q+ S+ ALK + S Q+
Sbjct: 823 KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE-------- 874
Query: 417 AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKR 476
LQ+K++E+ + LN + + + ++ S +TE+ +L++
Sbjct: 875 ----------LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE- 923
Query: 477 VVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKR 536
V L EK ++LK E L + +R+ + I D N
Sbjct: 924 VKTLTQEK----------DDLKQLQESL--------------QIERDQLKSDIHDTVNMN 959
Query: 537 SSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ-GKRAEEADHEVLDQ 595
+ E+ ++ LE+ ++H+E ++ L+ K ++E L ++ G+ +E +++
Sbjct: 960 IDTQEQL-RNALESL--KQHQE-TINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 596 KEMKQMEGEGI----APIKMKVFLEDTGQDFPLMPNE---ESSLPAV--EKEQASTEHQS 646
+ + +E + A +K +E + F L+ + + L +V EKEQ T+ +
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 647 RTSEEIS----LNDAGVELKSTKQD-GDKSLSAVPDIGQCHQDELERLKSQILELELNF- 700
I L G ELK ++ + A+ G EL R ++ E+E
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG-----ELSRTCDRLAEVEEKLK 1130
Query: 701 HKAQEIYEK-----NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV-- 753
K+Q++ EK N+ E+ E+ IE K N + ER +L ++
Sbjct: 1131 EKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190
Query: 754 --KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVK 811
+E+ +T+ R +K+L+ + E ER Y + L T++ E K +
Sbjct: 1191 NYEEVKSITKERKVLKELQKSF-ETERDHLRGYIREIEATGLQTKE------ELKIAHIH 1243
Query: 812 IEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK 871
++ Q +D+++ SE++ I I+++ E S Q+
Sbjct: 1244 LKEHQETIDELRRSVSEKTAQI-----------------------INTQDLEKSHTKLQE 1280
Query: 872 ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTL 931
E+ + +Q LL ++V Q+T+ E + + + + + ++ E+ L + +
Sbjct: 1281 EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQES 1340
Query: 932 KEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN--- 988
+E++ L++ + K E LK++ E Q S+ + + ++ +K+N
Sbjct: 1341 QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETT 1400
Query: 989 ------EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP---LSETERGEVEE 1039
EQ K K A L E+L RL+E +K +K++ L E + E ++
Sbjct: 1401 KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ 1460
Query: 1040 DKEN-KEYSEK------------CVTSKCQEIEIYLKQTISEKEVELQHIRKDLE----- 1081
KEN KE K C + +E L+ +SEKE E+ I+K LE
Sbjct: 1461 LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDK 1520
Query: 1082 ------EKLAAEEQFQALVKQMNQTLQDKTNQI----DLLQAEISENQAIIQKL--ITSN 1129
E EEQF +KQ+++ +Q+K N++ + +A+ S Q+I K+ +T+
Sbjct: 1521 LQNKIQEIYEKEEQFN--IKQISE-VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNR 1577
Query: 1130 TDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKA 1189
S + ++KE K E++ AL+ E++QL++ +E + A
Sbjct: 1578 LQESQEEIQIMIKE---------------KEEMKRVQEALQIERDQLKENTKEIV----A 1618
Query: 1190 ILKKAQEKERHLRE-----ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI 1244
+K++QEKE + E +++ + L+EQF+ Q ENI + +L + E++
Sbjct: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENL 1678
Query: 1245 DGKLPSTDQQESCSST------------PGLEEPLFKATEQHHTQPVLESNLCPDWPSHS 1292
+ T +++ S L E + + E+ ++ +L H
Sbjct: 1679 EEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL----KEHQ 1734
Query: 1293 EDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLE 1352
E L+G + + EI + +LE + ++ K EE+ + +Q
Sbjct: 1735 ETIDKLRG-----IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
Query: 1353 IESLKTVSHEAEVHAESLQQKLESSQLQI-AGLEHLRELQPKLDELQKLIS---KKEEDV 1408
I+ L+ + E ++Q+ LE+S ++ ++ L+ + +L L+K ++ KK ++
Sbjct: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEM 1849
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVE---LCEMK 1465
L Q+ ++ L+K++ IE +L + LH LE ER +VE E
Sbjct: 1850 EQLKKQIKDQSLTLSKLE---IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906
Query: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1525
Q E + E +IQ++L+ A + KE + L+E++S I + K L +S
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD--KS 1964
Query: 1526 QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEK 1585
+ Q K ++ L LL+ + D + + + E + L E+ L+++ + D +
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKED--VNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQ 2022
Query: 1586 LVKEI-ESLKSSKIA--ESTEWQEKHKELQKEYEILLQSY-ENVSNEAERIQHVVEAVRQ 1641
L K++ ESL+ +I E E + + L+ E + + + E ++ + + Q V+
Sbjct: 2023 LTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ-----VKP 2077
Query: 1642 EKQELY-GKLRSTEANKKETE--KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR 1698
EK+ L G+ TE+ +++ K+L + EM++ E + + + +++I +E + R
Sbjct: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMR 2137
Query: 1699 LRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD 1758
++A + K +E L ++N +R ME+ + KK + ++S + EE +
Sbjct: 2138 VKANLSLPYLQTKH-IEKLFTAN-------QRCSMEFHRIMKKLKYVLSYVTKIKEEQHE 2189
Query: 1759 LKHQIE----GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSES 1814
++ E V KQ L +H Q +P L+ + E
Sbjct: 2190 SINKFEMDFIDEVEKQKELLIKIQHLQQ-------DCDVPSRELRDLKLNQNMDLHIEEI 2242
Query: 1815 VPS-AKSANPAVSKDF----SSHDEINNYLQQ-------IDQLKERIAGLEEEK----QK 1858
+ ++S P++ +F S+ E+ +L++ I++LK G+++E Q
Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN---GIQKENDRICQV 2299
Query: 1859 NKEFSQ---TLENEKNTLLSQISTKDGE----LKMLQEEVTKMNLLNQQIQEELSRVTKL 1911
N F+ + NE + +T E LK L+E+ K+ Q ++ L+ ++
Sbjct: 2300 NNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQV 2359
Query: 1912 KETAEEEKD-DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
T ++ K+ + R E + N + ++ + E +M+ + +++
Sbjct: 2360 NPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIA 2419
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
+ Q V E K E KE ++ +Q + G K + +E+++L + + + K+
Sbjct: 2420 KLQAKVHESNKC-LEKTKETIQVLQD-KVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE 2477
Query: 2031 YQEKISALERTVKALEFVQTESQKD-LEITKENLAQAVEHRKKAQAELASFKVLLDDTQ- 2088
++++ISA + TV E QK+ + + +ENL R+ QA+ S D Q
Sbjct: 2478 FEKEISATKATV--------EYQKEVIRLLRENL------RRSQQAQDTSVISEHTDPQP 2523
Query: 2089 ----------------SEAARVLADNLKLKKELQSNKESVKSQMKQKDE------DLERR 2126
++A + +++++L+KE+ K+ + +KQK+E L
Sbjct: 2524 SNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNE 2583
Query: 2127 LEQAEEKHLKEKKNMQ 2142
++ +E+ LK + + Q
Sbjct: 2584 VKTWKERTLKREAHKQ 2599
Score = 241 bits (616), Expect = 7e-63
Identities = 447/2155 (20%), Positives = 887/2155 (41%), Gaps = 376/2155 (17%)
Query: 4 RLSGLANVVLHELSGDDDTDQNMRAPLDPE---LHQESDMEFNNTTQEDVQERLAYAEQL 60
+L + + + L +D Q + D E L + + F + +++E++
Sbjct: 602 KLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATT 661
Query: 61 VVELKDIIRQKDVQLQQKDEA---LQEERKAADNKIKKL--------------KLHAKAK 103
++++ I+ QL+ K + L++E ++A N+I KL L + K
Sbjct: 662 YKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 721
Query: 104 LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE---LI 160
+T L K + + V E EE + + S E +E+++ ++Q+K E +I
Sbjct: 722 ITDLQKELNK------EVEENEALREEVILLSELKSLPSE--VERLRKEIQDKSEELHII 773
Query: 161 STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA-----EQAA 215
++ + +L + ++ +EE K L + + + + EQ
Sbjct: 774 TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKY 833
Query: 216 QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV 275
+ V+ E + + V L ++ + ++TE+ K + LQ K E +E L Q+
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893
Query: 276 DLLQQE---LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
+ L+ L E+ +++++LQQ E TL E+++ K L E +++E + K
Sbjct: 894 EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ----EKDDLKQLQESLQIERDQLK 949
Query: 333 LSFHNL-------QEEMHHLLEQFEQ-------------------------AGQAQAELE 360
H+ QE++ + LE +Q G+ + E +
Sbjct: 950 SDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQ 1009
Query: 361 SRYSALEQKHKAEME---------------EKTSHILSLQKTGQELQSACDAL---KDQN 402
+ +++K E + E+ I SL + ELQ +++ K+Q
Sbjct: 1010 QKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQL 1069
Query: 403 SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQ----TSFPDVY 458
L++ E +++ + ++ L D+L+++ + ++Q N ++ E + +
Sbjct: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL 1129
Query: 459 NEGTQAVTE---------ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT 509
E +Q + E E ++ +QK++ E+EN K L + LE ++ E
Sbjct: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER-------- 1181
Query: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL-------ENTFSQKHKELSVL 562
LE + E EV I+ K + E+ +D L E T Q +EL +
Sbjct: 1182 -LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240
Query: 563 LLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEG--------EGIAPIKMKVF 614
+ +KE QE I L+ + K A+ + + L++ K E E + +K
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300
Query: 615 LEDTGQDFPLMPNEESS-----LPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGD 669
++T + L+ + ++ L +E E+ + + S+E E+KS ++ D
Sbjct: 1301 TQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQE--------EIKSLTKERD 1352
Query: 670 KSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFK 729
+L + + + D+L K I E ++Q E++L+ K K+ + +++ E +
Sbjct: 1353 -NLKTIKEALEVKHDQL---KEHIRETLAKIQESQSKQEQSLNMKEKD-NETTKIVSEME 1407
Query: 730 KNADNNSSAFTA----------LSEERDQLLSQVKE---LSMVTE-LRAQVKQLEMNLAE 775
+ +S+ L E D++ S KE L + E L+++ QL+ N+ E
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 776 -AERQRRLDYESQTAHDNLLTEQ--IHSLSIEAKSKDVKIEVLQNELDDV---------Q 823
+ + E + AH L ++ I+ L + K+ +I +Q +L+ + +
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527
Query: 824 LQFSEQSTLIRSLQSQLQNKESEVLEGAER-------VRHISSKVEELSQALSQKELEIT 876
+ E+ I+ + S++Q K +E+ + E ++ I SK+ EL+ L + + EI
Sbjct: 1528 IYEKEEQFNIKQI-SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Query: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE---------KMVQLNEEKFSLGVE 927
M + E KR E LQ ++ + EI M E KM +NE + + E
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM-CE 1645
Query: 928 IKTLKEQLNLLSRAEEAKKEQVEEDN-EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
I+ LKEQ ++ E +E +N ++ L +N +EM + +++L+ + LK
Sbjct: 1646 IEHLKEQFE----TQKLNLENIETENIRLTQILHENLEEMRSVTK-ERDDLRSVEETLKV 1700
Query: 987 ENEQRKRKLQAAL---INRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKEN 1043
E +Q K L+ + + ++E L+ V +E D+ + + E +++D E+
Sbjct: 1701 ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
Query: 1044 KEYSEKCVTSKCQE----IEIYLKQT----------ISEKEVELQHIRKDLE-------- 1081
+ K K QE ++LK+ +SEK +L +++KDLE
Sbjct: 1761 SNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
Query: 1082 ---EKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138
E A E Q L K +N+T Q K ++++ L+ +I + + KL N + +
Sbjct: 1821 KIQELKANEHQLITLKKDVNET-QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE 1879
Query: 1139 ALVKETVVISPPCTGSSEHWKPELEEKILALEKE--KEQLQK------KLQEALTSRKAI 1190
L + V+ E E+ L LE++ KE LQ+ ++Q+ L + + +
Sbjct: 1880 NLEEMKSVMK-------ERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARML 1932
Query: 1191 LKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ---VRESIDGK 1247
K+ +E LRE++ ++ + +Q+ D+ E + +L++ ++Q V+E ++
Sbjct: 1933 SKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMS 1992
Query: 1248 LPSTDQQESCS--------STPGLEEPLFKATEQHHTQPVLESNLCP---DWPSHSEDAS 1296
++ E S + F+ T++ H + + E + D +++
Sbjct: 1993 HKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH-ESLEEIRIVAKERDELRRIKESL 2051
Query: 1297 ALQGGTSVAQIKAQLK------EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQG 1350
++ +A ++ + +++ EK L T L +K + +L ++ ++
Sbjct: 2052 KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD 2111
Query: 1351 LEIESLKTVSHEAEVHAE-------SLQQKLESSQLQIAGLEHLRELQPKLD-ELQKLIS 1402
E L +S + E E ++ L LQ +E L + E +++
Sbjct: 2112 DHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMK 2171
Query: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQ-----EDLIKALHTQLEMQAKEHDERIKQL 1457
K + +SY++ E+ ++ K + + I++ E LIK H Q + + R +L
Sbjct: 2172 KLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKL 2231
Query: 1458 QVELCEMKQKPEEIGEESRAKQ--QIQRKLQAALISRKEALKENKSLQEELSLARGTIER 1515
M EEI ++ + I+ + Q L +RKE + EE R IE+
Sbjct: 2232 NQN---MDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQ----FLEEWLNTRFDIEK 2284
Query: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLA 1575
L + Q+E D++ + N+ ++ ES
Sbjct: 2285 LKNGI------------------------QKENDRICQV--NNFFNNRIIAIMNES---- 2314
Query: 1576 LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNE-AERIQH 1634
TE +E+ S+ I S EW++ K L+++ E L ++Y+ + A Q
Sbjct: 2315 ----TEFEER---------SATI--SKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ- 2358
Query: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
V Q+ + + R+T+ T ++++E E + E KE A K+ KI+++++
Sbjct: 2359 -VNPTTQDNKNPHVTSRATQL----TTEKIRELENSLHEAKES----AMHKESKIIKMQK 2409
Query: 1695 E----ND---RLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMS 1747
E ND +L+A+VH + +C+E KE ++ ++ + +K ++
Sbjct: 2410 ELEVTNDIIAKLQAKVHESN----KCLE-------KTKETIQVLQDKVALGAKPYK---- 2454
Query: 1748 EKDSLSEEVQDLKHQ-IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMS 1806
EE++DLK + ++ ++ K N + EK + T T E + + E S
Sbjct: 2455 ------EEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQ 2508
Query: 1807 TRPTC--SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQ 1864
+ T SE S P S + L LK LE+E K K+ ++
Sbjct: 2509 AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI----LKSEHIRLEKEISKLKQQNE 2564
Query: 1865 TLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEK 1919
L +KN LLS E+K +E K Q E + K+ TA ++K
Sbjct: 2565 QLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKK 2619
Score = 201 bits (511), Expect = 1e-50
Identities = 291/1511 (19%), Positives = 650/1511 (43%), Gaps = 214/1511 (14%)
Query: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905
K+++A L EEK + Q ++NEK L+++ L + QE K +++ L
Sbjct: 373 KDQLAQLLEEK----DLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRK---RRVTWCL 425
Query: 1906 SRVTKLKETAEEEKDDLEERL--------MNQLAELNGSI-------GNYCQDVTDAQ-- 1948
++ K+K + ++ ++ + +N L E++ S+ N +++ +
Sbjct: 426 GKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWN 485
Query: 1949 -----IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK-------EYLEKIQG 1996
+ E +ESE+ +L+ L + +QL EK ++E ++++ E LE+
Sbjct: 486 PATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTK 545
Query: 1997 AQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKAL-EFVQTESQKD 2055
+E L+ L+K + + L+ + E + E +K L E++ ++ ++
Sbjct: 546 KDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLEN 605
Query: 2056 LEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS- 2114
+++ +++E K+ + L + + D + E+A + ++NL+LK++++ + K
Sbjct: 606 IKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQM 665
Query: 2115 ----QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKV--------HLEETIGEI 2162
Q+ Q + +++++ EK L+ N KL +L KV LE I ++
Sbjct: 666 ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725
Query: 2163 QVTLNKKDKEVQQLQEN--LDSTVTQLAAFTKSM-SSLQDDRDRVIDEAKKWERKFSDAI 2219
Q LNK+ +E + L+E L S + L + + + +QD + + + ++ FS+ +
Sbjct: 726 QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785
Query: 2220 QSKE------EEIRLKEDNCSVLKDQLRQMSIHMEELK-INISRLEHDKQIWESKAQTEV 2272
+ EEI +D+ + + + + K +++ + K + E +
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 2273 QL------QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSN 2326
++ QK +L EL + +E + Q L +E++ LK+QL + +
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL----NEMEQLKEQLENRDS 901
Query: 2327 SLEKCKEQKGNLEGIIRQQEADIQN---SKFSYEQLETDLQASRE-LTSRLHEEINMKEQ 2382
+L+ + +K + ++Q +++ K +QL+ LQ R+ L S +H+ +NM
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 2383 KIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLM 2442
+E ++ A+ L+Q H + I L++ +S+E N+ +EE + D+ Q M
Sbjct: 962 T--------QEQLRNALESLKQ-HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKM 1012
Query: 2443 --------------ETLKTIKKEN--IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE-- 2484
+TL K+N I+Q+ ++ S ++ + LQ + ++ + +QL+
Sbjct: 1013 VGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTD 1072
Query: 2485 -ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
+ ++ + +E + ++ E K +E + ++H E ++ L + E L +
Sbjct: 1073 LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEK 1132
Query: 2544 ITIKDSQQKQLLEVQLQQNK-------------ELENKYAKLE----EKLKESEEANEDL 2586
+Q+QLL VQ + ++ EL+NK LE E+L+ +++ NE+
Sbjct: 1133 SQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENY 1192
Query: 2587 RRSFNALQEEK--QDLSKEIESLKVSISQLTRQV--TALQEEGTLGLYHAQLKVKEEEVH 2642
+ +E K ++L K E+ + + R++ T LQ + L + H LK +E +
Sbjct: 1193 EEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Query: 2643 RLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAE 2702
L S +I ++ + + KL++E+ LH + ++ N E +E
Sbjct: 1253 ELRRSVSEKTAQIINTQD------------LEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300
Query: 2703 --ERVAEL-----------ARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
E + EL + L +E + L + ++ + +I+S + +L+ ++
Sbjct: 1301 TQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEA 1360
Query: 2750 ANEELDELK---RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKL 2806
+ D+LK R+ A ++E +EQ L +E+D +ET ++ E+ +
Sbjct: 1361 LEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD---NETTKIVSEMEQ-----FKPK 1412
Query: 2807 NQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS-------- 2858
+ LL + ++L LS +L++S+++++S +K LQ ++ L +E ++ +++
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 2859 -----------------EEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ 2901
EE S E+ +++K + ++ + ++E+ +
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 2902 QQY-----LQINQEITELHPLK-------AQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949
+Q+ ++ +++ EL K + LQ + K +E ++E E
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 2950 HQLRMEKSSWEIHERRMKEQYLMAISD-KDQQLSHLQNL----IRELRSSSSQTQPLKVQ 3004
+++ + + +I ++KE ++ K+ Q Q L + E + + + LK Q
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 3005 YQRQASPETSASPDG---SQNLVYETELLR--TQLNDSLKEIHQK-ELRIQQLNSNFSQL 3058
++ Q + + +Q L E +R T+ D L+ + + ++ QL N +
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712
Query: 3059 LEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEK- 3117
+ +L L+E+Q+ L + ++ +Q + + A A K
Sbjct: 1713 ITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772
Query: 3118 ------NGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENAL 3171
+H K E + + + SE +L N ++++ L+E+ + A E+ L
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQL 1832
Query: 3172 SVAEEQIRRLE 3182
++ + +
Sbjct: 1833 ITLKKDVNETQ 1843
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 263 bits (672), Expect = 2e-69
Identities = 534/2604 (20%), Positives = 1083/2604 (41%), Gaps = 471/2604 (18%)
Query: 754 KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIE 813
++ + L + ++E+N ++E+Q + IH I +K +
Sbjct: 20 RQEELADNLLISLSKVEVNELKSEKQENV---------------IHLFRITQSLMKMKAQ 64
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV-----LEGAERVRHISSKVEELSQAL 868
++ L++V+ EQ+ L++++ E+E+ G R + +++ +L + L
Sbjct: 65 EVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
Query: 869 SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEI---SFSMTEKMVQLNEEKFSLG 925
QK+ E+ M++ L ++K+ E L EE + + +++ + + +K QL ++
Sbjct: 125 EQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQ 184
Query: 926 VEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL-KQNYDEMSPAGQISKEELQHEFDLL 984
+I + KE LLSR E D++ S L K+NY+ + +I + L + +
Sbjct: 185 KQIDSQKE--TLLSRRGE--------DSDYRSQLSKKNYELIQYLDEI--QTLTEANEKI 232
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLE---EELANLKDESKKEIPLSETERGEVEEDK 1041
+ +N++ ++ L+ ++ +++ +R++ + N+ D+ KKE + + E+ +
Sbjct: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
Query: 1042 ENKEYSEK----CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL--AAEEQFQALVK 1095
++K + V +K +E ++ L ++ +E Q + +L EKL A + ++ V
Sbjct: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSK-DDEIIEYQQMLHNLREKLKNAQLDADKSNVM 351
Query: 1096 QMNQTLQDKTNQIDLLQAEISE-------NQAIIQKLITSNTDASDGDSVALVKETVVIS 1148
+ Q +Q++ +QI +L ++ + N II+ L N + + L ++T
Sbjct: 352 ALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDL--KNELQRNKGASTLSQQT---- 405
Query: 1149 PPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQ 1208
H K ++ + L++K +EA + + A+EK++ L E LK+
Sbjct: 406 --------HMK---------IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRL 448
Query: 1209 KD-------------DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
KD + + Q + +E E + ++ +L++++ + +D + E
Sbjct: 449 KDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLD-------ENE 501
Query: 1256 SCSSTPGLE-EPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEI 1314
+ GLE + + TE +++ + + +E+ L+ +++ +
Sbjct: 502 ALRERVGLEPKTMIDLTEFRNSKHLKQQQY------RAENQILLK----------EIESL 545
Query: 1315 EAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374
E E+++L+ K+ E K+S GL E L + ++ ++
Sbjct: 546 EEERLDLKKKIRQMAQERGKRSAT----------SGLTTEDLNLTENISQ------GDRI 589
Query: 1375 ESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434
+L + L+++ E Q K + +LS +L EKE L + +T I + ++
Sbjct: 590 SERKLDLLSLKNMSEAQSKNE--------------FLSRELIEKERDLERSRTVIAKFQN 635
Query: 1435 LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEES--------RAKQQIQRKLQ 1486
+K +L + K+ +E +K++ + EM++ P+ G E+ R I+ K
Sbjct: 636 KLK----ELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNA 691
Query: 1487 AALISRKEALK--------ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVL 1538
+ LK N+ L++EL +R ++ LA ++ + + EK+T L
Sbjct: 692 EGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLA--KANLKIDHLEKETSL 749
Query: 1539 GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
R + K I D + S+ +S + L E+KEK +K +E
Sbjct: 750 LRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLED------ 803
Query: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
++ K ++ + +L + Y +E E + + +++EK++L +++ K
Sbjct: 804 -SLEDYNRKFAVIRHQQSLLYKEY---LSEKETWKTESKTIKEEKRKLEDQVQQDAIKVK 859
Query: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
E L + + +EMK K +KI L+ L + T E L
Sbjct: 860 EYNNLLNALQMDSDEMK----KILAENSRKITVLQVNEKSLIRQY----TTLVELERQLR 911
Query: 1719 SSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEK 1778
N K EL + ME E + +K L K+ ++ L+ ++ +VS + LE K
Sbjct: 912 KENEKQKNEL--LSMEAE-VCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELANK 967
Query: 1779 HDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY 1838
N+ + ++D++ + +++N H E N
Sbjct: 968 QYNELTAKYR-------DILQKDNMLVQ------------RTSN-------LEHLECENI 1001
Query: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTLEN--EKNTLLSQISTKDGELKMLQEEVTKMNL 1896
LKE++ + +E + KE T+E E+ T L S+ D K ++
Sbjct: 1002 -----SLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDK---------AKKSI 1047
Query: 1897 LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956
N I ++T L E +L ER Q AE +CQ + E L +
Sbjct: 1048 TNSDIVSISKKITML------EMKELNER---QRAE-------HCQKMY------EHLRT 1085
Query: 1957 EMKNLKKCVSELEEEKQQLVK---EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
+K +++ ELE + +L K + KVE +R E + + A + + Q +
Sbjct: 1086 SLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDA-------DRQRI 1138
Query: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA--QAVEHRK 2071
L+ ++ E+ +L+ + + +E R V+ L Q K++E + L QA K
Sbjct: 1139 LELEKNEM-ELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEK 1197
Query: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE 2131
A+L V L +++ A L ES+ S++ QK E RLEQ
Sbjct: 1198 SLIAKLHQHNVSLQLSEATALGKL--------------ESITSKL-QKMEAYNLRLEQKL 1242
Query: 2132 EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT 2191
++ KE+ +L+ R K HL +TI ++ +Q L + Q F+
Sbjct: 1243 DE--KEQALYYARLEGRNRAK-HLRQTIQSLR----------RQFSGALP--LAQQEKFS 1287
Query: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK----EDNCSVLKDQLRQMSI-- 2245
K+M LQ+D+ +++ E K +++ + +++K E+ LK E+ S LKD +
Sbjct: 1288 KTMIQLQNDKLKIMQEMKNSQQEHRN-MENKTLEMELKLKGLEELISTLKDTKGAQKVIN 1346
Query: 2246 -HMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET---RHLYH 2301
HM+ ++ + L+ ++++ + K + K + + E + +S LEE ++ +H
Sbjct: 1347 WHMKIEELRLQELKLNRELVKDKEEI------KYLNNIISEYERTISSLEEEIVQQNKFH 1400
Query: 2302 SSQNEL-----AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
+ LE +L Q ++ N+ +K +E G+ I + N
Sbjct: 1401 EERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGS----IPDPSLPLPN----- 1451
Query: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE-N 2415
QLE L+ +E R+ E + + L KE A+++A + + DK I EL
Sbjct: 1452 -QLEIALRKIKE-NIRIILETRATCKSLEEKLKEKESALRLAEQNILSR-DKVINELRLR 1508
Query: 2416 LLSQEEEENIVLEEENKKAVDKTNQLM----ETLKTIKKENIQQKAQLDSFVKSMSSLQN 2471
L + E E ++ E K+ K++ + +T+ ++ Q++ L + + + +
Sbjct: 1509 LPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKARE 1568
Query: 2472 DRDRIVGDYQQ-LEERHLSIILEKDQLIQE-------------AAAENNKLKEEIRGLRS 2517
++ IV +++ L H + L+ D + + NK + +
Sbjct: 1569 EQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ 1628
Query: 2518 HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL--LEVQLQQNKELENKYAKLEEK 2575
+ + + + L +L + +DL + I + + K+ +++QLQ+N E E K K E
Sbjct: 1629 TVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV- 1687
Query: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQL-TRQVTALQEEGTLGLYHAQL 2634
EDL+ + Q+E Q L E+++ K + S+ T + L E +QL
Sbjct: 1688 --------EDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVER-----LKSQL 1734
Query: 2635 KVKEEEVHRLS-ALFSSSQKRIAELEEELVCV--QKEAAKKVGEIEDKLKKELKHLHHDA 2691
+KE++ LS AL + A EE ++ QKEA V +I D+ +ELK
Sbjct: 1735 ALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELK------ 1788
Query: 2692 GIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751
+ E E + +L L + + +T L ++Q ++ + + ++ +
Sbjct: 1789 ----TQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEID 1844
Query: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
+E DELKR+ +K L + L + +L+ E + E +E+++ + +
Sbjct: 1845 QENDELKRQ----IKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPM 1900
Query: 2812 SKD---EQLLH-------------LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
+ E+L+ + ++L++ +V + +K + +L++ L+ + +K
Sbjct: 1901 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKD----LFAKADKE 1956
Query: 2856 RKSEEGKQRSAA---------QPSTSPAEVQSLKKAMSSLQND-----------RDRLLK 2895
+ + + K ++ + S E++ LKK L+ND RD +++
Sbjct: 1957 KLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
Query: 2896 ELKNLQQQYLQINQEITELHPLKAQLQ------------EYQDKTKAFQIMQEE---LRQ 2940
+L +LQ +YLQ +LH L+ Q E D + Q +Q+E L
Sbjct: 2017 DL-HLQNRYLQ-----EKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSS 2070
Query: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK---DQQLSHLQN------LIREL 2991
EN+ + +L Q + + R +KE +K ++L H++ I EL
Sbjct: 2071 ENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPEL 2130
Query: 2992 RSSSSQTQPLKVQYQRQASPETSAS----PDGSQNLVYETELLRTQLNDSLKEI-HQKEL 3046
+ + + + QR+ AS + N+ E E L+ +L + HQ +
Sbjct: 2131 EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSM 2190
Query: 3047 RIQQLNSNFSQLLEEKNTLSIQL---CDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAG 3103
+ +++ E L +L D ++ LR + + ++LN EK +L+
Sbjct: 2191 HYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNL-EILN-----EKMTVQLEET 2244
Query: 3104 PLNIDVAPGAPQEKNGVHRKSDPEEL--REPQQSFSEAQQQLCNTRQEVNELRKLLEE-- 3159
+ A + G KS + R + E + + Q + +L++L++E
Sbjct: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304
Query: 3160 ERDQRVAAENALSVAEEQIRRLEH 3183
ER+Q+V N E+QI+ L+H
Sbjct: 2305 EREQKVNKYN--EDLEQQIKILKH 2326
Score = 259 bits (663), Expect = 2e-68
Identities = 536/2687 (19%), Positives = 1103/2687 (41%), Gaps = 442/2687 (16%)
Query: 308 NTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE 367
N +++E++E+ I L ++ + + K +E+ LE+ E+AG+ QA+ E++
Sbjct: 38 NELKSEKQENVIHLFRITQSLMKMKA------QEVELALEEVEKAGEEQAKFENQLKT-- 89
Query: 368 QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQL 427
+ K EL+ A + ++++ L+++ I QLE QL
Sbjct: 90 ---------------KVMKLENELEMAQQSAGGRDTRFLRNE----------ICQLEKQL 124
Query: 428 QQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGAL 487
+QK +E+ L E + V E+ L R E ENE L
Sbjct: 125 EQKDRELEDMEKEL------------------EKEKKVNEQ----LALRNEEAENENSKL 162
Query: 488 LLSSIELEELKAENEKLSSQITLLEAQ---------NRTGEADREVSEIS-----IVDIA 533
E + LK +NE+L I + Q +R GE S++S ++
Sbjct: 163 ---RRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYL 219
Query: 534 NKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL------QLQGKRAEE 587
++ + E + + ++N +K+ E SV EM++ +E +K + + +E
Sbjct: 220 DEIQTLTEANEKIEVQNQEMRKNLEESV--QEMEKMTDEYNRMKAIVHQTDNVIDQLKKE 277
Query: 588 ADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLM-----PNEESSLPAVEKEQAST 642
DH L +E+ + +K K +D P+M EE L K+
Sbjct: 278 NDHYQLQVQELTDL-------LKSK-----NEEDDPIMVAVNAKVEEWKLILSSKDDEII 325
Query: 643 EHQSRTSEEISLNDAGVELKSTKQDGDKS-LSAVPDIGQCHQDELERLKSQILELELNFH 701
E+Q L++ +LK+ + D DKS + A+ Q +++ L Q+
Sbjct: 326 EYQQ------MLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQV-------- 371
Query: 702 KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTE 761
E Y K +++ I +L ++ K + + + D L + KE E
Sbjct: 372 ---EQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAE 428
Query: 762 L-RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELD 820
L A ++ + L EA +R DYES +I + + K +D +IE+L E++
Sbjct: 429 LAEADAREKDKELVEA-LKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEIN 487
Query: 821 DVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE--RVRHISSKVEELSQALSQKELEITKM 878
++L+ S+ +L+ ++ + +++ E +H+ + + KE+E +
Sbjct: 488 KLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEE 547
Query: 879 DQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLL 938
++L L+KK ++Q +E+ ++ + +T + + L E S G I K L L
Sbjct: 548 ERLDLKKK-----IRQMAQERGKR--SATSGLTTEDLNLT-ENISQGDRISERKLDLLSL 599
Query: 939 SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 998
EA+ + NE +S+E ++ E DL +R R + A
Sbjct: 600 KNMSEAQSK-----NEF----------------LSRELIEKERDL------ERSRTVIAK 632
Query: 999 LINR-KELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057
N+ KEL++ +LEE + + K+ + + GE + E + SK E
Sbjct: 633 FQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAE 692
Query: 1058 ----IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQA 1113
++LK + + + +R++L E + + + N + + LL+
Sbjct: 693 GIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
Query: 1114 EISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL---EEKILALE 1170
N ++ D DG +A +++ S H EL E+K+ LE
Sbjct: 753 SEGSN------VVFKGIDLPDG--IAPSSASIINSQ--NEYLIHLLQELENKEKKLKNLE 802
Query: 1171 KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG 1230
E +K + + K+ ++ + E K K++ +L++Q + + + +
Sbjct: 803 DSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYN 862
Query: 1231 DQLRQLQI------QVRESIDGKLPSTDQQESC-----SSTPGLEEPLFKATEQHHTQPV 1279
+ L LQ+ ++ K+ E ++ LE L K E+ + +
Sbjct: 863 NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELL 922
Query: 1280 -LESNLCPDWPSHSEDASALQGGTSVAQIK-AQLKEIEAEKVEL-ELKVSSTT-SELTKK 1335
+E+ +C E LQ +A K A L+++ V L EL++++ +ELT K
Sbjct: 923 SMEAEVC-------EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAK 975
Query: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
++ Q + ++ +E L+ + + ES+ ++LE ++ ++ +E E + KL
Sbjct: 976 YRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLG 1035
Query: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK 1455
+ K+ + +S+K L + ++ + + ++ L K+ +ER
Sbjct: 1036 NESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF 1095
Query: 1456 QLQVELCEM------KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLA 1509
+L+ + E+ QK E++ + A + A E K L+ E+S
Sbjct: 1096 ELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL 1155
Query: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDK--LITEMDRSLLENQSLSS 1567
R + + + + +Q +++KE +++ +L Q + D+ LI ++ + N SL
Sbjct: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQ---HNVSLQL 1212
Query: 1568 SCESLKLALEGLTEDKEK-------LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620
S + LE +T +K L ++++ + + E + + K L++ + L +
Sbjct: 1213 SEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRR 1272
Query: 1621 SYENV--SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKM 1678
+ + E+ + ++ +K ++ ++++++ + E + E E +++ ++E +
Sbjct: 1273 QFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELI 1332
Query: 1679 RKFAKSK-QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK----- 1732
+K QK++ + + LR + L N + ++ E +K
Sbjct: 1333 STLKDTKGAQKVINWHMKIEELRLQE--------------LKLNRELVKDKEEIKYLNNI 1378
Query: 1733 -MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD--NQTNVTEEG 1789
EYE + + +++ EE Q Q E ++ +Q ++ ++++ N EE
Sbjct: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEA 1438
Query: 1790 TQSIPG--------------ETEEQDSLSMSTRPTC---SESVPSAKSANPAVSKDFSSH 1832
T SIP + +E + + TR TC E + +SA ++ S
Sbjct: 1439 TGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSR 1498
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE------LKM 1886
D++ I++L+ R+ T E EK L++++ K+ E LK+
Sbjct: 1499 DKV------INELRLRLPA-------------TAEREK--LIAELGRKEMEPKSHHTLKI 1537
Query: 1887 LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER------LMNQLAEL--NGSIG 1938
+ + M Q +E L + +L E A EE+ ++ ++ +++ EL + S+
Sbjct: 1538 AHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLN 1597
Query: 1939 NYCQDVTDAQIKNELLESEMKN------LKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
+ Q D ++ K+ +++ V+E ++ L+ + KV ++ ++
Sbjct: 1598 KFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ--- 1654
Query: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVK-QLQKDCIRYQEKISALERTVKALEFVQTE 2051
+E+ EL ++ + +K QLQ++ +++++ ++ V+ L+++ +
Sbjct: 1655 ---------------REITELKVKEFENIKLQLQEN---HEDEVKKVKAEVEDLKYLLDQ 1696
Query: 2052 SQKDLEITKENLAQAVEHRKKAQA--------ELASFKVLLDDTQSEAARVLADNLKLKK 2103
SQK+ + K L E +A L S L + Q +R L L+L+
Sbjct: 1697 SQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRAL---LELRA 1753
Query: 2104 EL-QSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL--------DALRREKVH 2154
E+ + +E + S QK+ L ++Q ++H +E K E L +AL+ K
Sbjct: 1754 EMTAAAEERIISATSQKEAHL--NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNR 1811
Query: 2155 ---LEETIGEIQVTLNKKDK-------EVQQLQENLDSTVTQLAAFTKSMSS--LQDDRD 2202
L + + ++ L KK K E +++ + D Q+ T + L D++
Sbjct: 1812 ENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQ 1871
Query: 2203 RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262
+I+E ++ +K + ++ K EE+ LK K++L I EE K
Sbjct: 1872 SLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEEL----IRWEEGK----------- 1916
Query: 2263 IWESKAQ-TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKS----- 2316
W++K + +L++K +GE L QL + L+ + E L+ +LK+
Sbjct: 1917 KWQAKIEGIRNKLKEK-----EGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTV 1971
Query: 2317 ---LKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ-ASRELTSR 2372
L + + LE+ K++ +LE I A + + + DL +R L +
Sbjct: 1972 DQVLGIRALESEKELEELKKRNLDLENDILYMRA---HQALPRDSVVEDLHLQNRYLQEK 2028
Query: 2373 LH--EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEE 2430
LH E+ K+ +SG E H + +EL ++EN+ L E
Sbjct: 2029 LHALEKQFSKDTYSKPSISGIES----------DDHCQREQEL-------QKENLKLSSE 2071
Query: 2431 NKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQ---LEERH 2487
N + + Q + L +K + K + K + +Q + G + + E
Sbjct: 2072 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELE 2131
Query: 2488 LSIILEKDQLIQEAAAENNKLKEEIRGLRSH-MDDLNSENAKLDAELIQYREDLNQVITI 2546
+I L K +++++ EN +LK+ L S M ++ EN KL AEL + + L +++
Sbjct: 2132 KTIGLMK-KVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSM 2190
Query: 2547 KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIES 2606
+ + E + +N+ +L ++LK+ +A E LR + K +L E
Sbjct: 2191 HYESKTKGTEKIIAENE-------RLRKELKKETDAAEKLRIA-------KNNLEILNEK 2236
Query: 2607 LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL---- 2662
+ V + + +++ + G QL+ + + + + + ++ ELE ++
Sbjct: 2237 MTVQLEETGKRLQFAESRG------PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
Query: 2663 --VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL 2720
+ K+ K+ E E K+ K + L I+++ E AE L R+L +
Sbjct: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG-LKRELQVLRLANH 2349
Query: 2721 MVTKENKGLTAQIQSFGRSMSSLQNS---RDHANEELDELKRKYDASLKELAQLKEQGLL 2777
+ KE L QI++ + S +++ D E++ +L+ + S E LKE+ +
Sbjct: 2350 QLDKEKAELIHQIEA-NKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEE--I 2406
Query: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
+ + L + E+ ++ E++ + +L +E++ LS QL
Sbjct: 2407 KKLKKELENFDPSFFEEIEDLKYNYKEEVKKNIL-LEEKVKKLSEQL 2452
Score = 258 bits (660), Expect = 5e-68
Identities = 542/2563 (21%), Positives = 1070/2563 (41%), Gaps = 386/2563 (15%)
Query: 61 VVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120
+ +L+ + QKD +L+ ++ L++E+K + ++ A+ + + L + + +K
Sbjct: 117 ICQLEKQLEQKDRELEDMEKELEKEKK-VNEQLALRNEEAENENSKLRRENKRLK----- 170
Query: 121 VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180
+ EQL + + + +I+ K L + S ++QL ++ +
Sbjct: 171 ------KKNEQLC---QDIIDYQKQIDSQKETLLSRRGEDSDYRSQL--------SKKNY 213
Query: 181 EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDA--RFETQVRLHEDELL 238
E+ +++ Q L E E I +Q Q + E++ Q++ + D R + V ++ +
Sbjct: 214 ELIQYLDEIQTLTEANEKIE-VQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVID 272
Query: 239 QLVTQAD-VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQ 297
QL + D + ++Q+ +L+ K EE + +V V+ + +L + + ++I+ Q
Sbjct: 273 QLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVE--EWKLILSSKDDEIIEYQ-- 328
Query: 298 QMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQA 357
+ HN + + K + ++ + ER ++ L EQ EQ +
Sbjct: 329 --QMLHNLREKLKNAQLDADKSNVMALQQGIQER-------DSQIKMLTEQVEQYTK--- 376
Query: 358 ELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSA 417
E+E +E K + LS Q+T ++QS D LK E+ ++
Sbjct: 377 EMEKNTCIIEDLKNELQRNKGASTLS-QQTHMKIQSTLDILK-----------EKTKEAE 424
Query: 418 QTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRV 477
+T + E ++K KE+ + L R L+ +E+ + L+ V
Sbjct: 425 RTAELAEADAREKDKELVEALKR--LKDYES--------------------GVYGLEDAV 462
Query: 478 VELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRS 537
VE++N K + + E+E L E KL +I+ +N + +++D+ R+
Sbjct: 463 VEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRN 522
Query: 538 SSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLK------LQLQGKRAEEADHE 591
S + Q EN +LL E++ +EE LK Q +GKR+ +
Sbjct: 523 SKHLKQQQYRAEN---------QILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLT 573
Query: 592 VLDQKEMKQM-EGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSE 650
D + + +G+ I+ K+ + SL + + Q+ E SR
Sbjct: 574 TEDLNLTENISQGDRISERKLDLL----------------SLKNMSEAQSKNEFLSR--- 614
Query: 651 EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFH---KAQEIY 707
EL ++D ++S + + Q++L+ L + +LE +A +
Sbjct: 615 ---------ELIEKERDLERSRTVIAKF----QNKLKELVEENKQLEEGMKEILQAIKEM 661
Query: 708 EKNLDEKAKE----ISNLNQLIEEFK-KNADNNSSAFTALSEERDQLLSQVKELSM-VTE 761
+K+ D K E I +L +L+ + KNA+ A L + DQL + +EL + E
Sbjct: 662 QKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRE 721
Query: 762 LRAQVKQLEMNLAEA-------ERQRRLDYESQTAH-------------------DNLLT 795
R + LA+A E++ L +S+ ++ N
Sbjct: 722 SRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQN 781
Query: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFS----EQSTLIRSLQSQLQNKESEVLEGA 851
E + L E ++K+ K++ L++ L+D +F+ +QS L + S+ + ++E
Sbjct: 782 EYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTE----- 836
Query: 852 ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
+ I + +L + Q +++ + + LL + D + +++ + E +++T
Sbjct: 837 --SKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKIT------- 887
Query: 912 EKMVQLNEEKFSLGVEIKTLKE-QLNLLSRAEEAKKEQVEEDNEVSS--GLKQNYDEMS- 967
++Q+NE+ SL + TL E + L E+ K E + + EV G Q + EM+
Sbjct: 888 --VLQVNEK--SLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAI 943
Query: 968 ---PAGQ--ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE---ELANL 1019
A Q + E +L K+ + K + L L+QR S LE E +L
Sbjct: 944 FKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISL 1003
Query: 1020 KDESK---KEIPLSETERGEVEE--DKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
K++ + KE+ +++ + +E+ ++E K +E + + I +IS+K L+
Sbjct: 1004 KEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLE 1063
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134
K+L E+ AE ++M + L+ Q++ E+ A + K+ N DA
Sbjct: 1064 --MKELNERQRAEH-----CQKMYEHLRTSLKQMEERNFELETKFAELTKI---NLDAQK 1113
Query: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194
+ + + +S + + ELE+ + L+ E +L +++ + + IL
Sbjct: 1114 VEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL-REISDIARRQVEILNAQ 1172
Query: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQS----KENENIGDQLRQ-LQIQVRESIDGKLP 1249
Q+ E L+ Q DY Q Q DE+S N+ QL + + ESI KL
Sbjct: 1173 QQSRDKEVESLRMQLLDY---QAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKL- 1228
Query: 1250 STDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKA 1309
Q+ + LE+ L + + + + N + +L+ S A A
Sbjct: 1229 ----QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHL---RQTIQSLRRQFSGALPLA 1281
Query: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAES 1369
Q ++ ++L+ E+ +E ++ + + L+++ L+ + S
Sbjct: 1282 QQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELI--------S 1333
Query: 1370 LQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI 1429
+ + +Q I + EL+ + +L + + K +E++ YL+ +SE E ++ ++ EI
Sbjct: 1334 TLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEI 1393
Query: 1430 IEQEDLIKALH---TQLEMQAKEHDERIKQLQVELCEMKQKPEE-IGEESRAKQQIQRKL 1485
++Q + Q E+ + + + Q E+ QK EE G + +L
Sbjct: 1394 VQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQL 1453
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES--QVSAQN-KEKDTVLGRLA 1542
+ AL +KEN + E R T + L + L + ES +++ QN +D V+ L
Sbjct: 1454 EIAL----RKIKENIRIILE---TRATCKSLEEKLKEKESALRLAEQNILSRDKVINELR 1506
Query: 1543 L---LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS-SKI 1598
L ER+KLI E+ R +E S +LK+A + + + +L ++ E LK ++
Sbjct: 1507 LRLPATAEREKLIAELGRKEME----PKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRL 1562
Query: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
E +E+ +E+ K++E E++ R++ ++ + ++ L
Sbjct: 1563 LEKA--REEQREIVKKHE------EDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPV 1614
Query: 1659 ETEK---QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECME 1715
T K +L E EQ + E + + ++ +LE + + +V KE
Sbjct: 1615 PTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV-------KEFEN 1667
Query: 1716 TLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA 1775
L + ++E+++VK E E L E L E+Q K+AN A
Sbjct: 1668 IKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQ---------AQKEANSRA 1718
Query: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI 1835
N+ E + + ++Q +LS + +E +A+ + + +H +
Sbjct: 1719 PT--TTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNV 1776
Query: 1836 NNYL-QQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
+ + +LK ++ L E K KE +T +N +N+L ++ + EL
Sbjct: 1777 QQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNEL---------- 1826
Query: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL 1954
Q+ Q+ +++ + KE ++E D+L+ ++ + L G + +TD K L+
Sbjct: 1827 ----QKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQG------KPLTDN--KQSLI 1874
Query: 1955 ESEMKNLKKCVSELEEEKQQL----VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010
E + +KK ++LE + +++ +KEK E IR E +K Q + NK KE
Sbjct: 1875 EELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEG 1934
Query: 2011 QELLKEKQ-QEVKQL----QKDCIRYQEKISALERTV-KALEFVQTESQKDL-EITKENL 2063
+ KQ +K L K+ + Q K+ TV + L ES+K+L E+ K NL
Sbjct: 1935 EVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNL 1994
Query: 2064 -----------AQA-----------VEHRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101
QA +++R + A K DT S+ + ++
Sbjct: 1995 DLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPS---ISGIES 2051
Query: 2102 KKELQSNKESVKSQMKQKDEDLERR--LEQAEEKHLKEKKN----MQEKLDALRREKVHL 2155
Q +E K +K E++E + LEQA K L KN ++E + L++EK +
Sbjct: 2052 DDHCQREQELQKENLKLSSENIELKFQLEQA-NKDLPRLKNQVRDLKEMCEFLKKEKAEV 2110
Query: 2156 E-------------ETIGEIQVTLNKKDKEVQQLQ-ENLDSTVTQLAAFTKSMSSLQDDR 2201
+ +TI E++ T+ K V+++Q EN ++ M++++ +
Sbjct: 2111 QRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQEN 2170
Query: 2202 DRVIDEAKKWE----RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKI---NI 2254
+++ E +K + + S +SK + L+ +L++ + E+L+I N+
Sbjct: 2171 EKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNL 2230
Query: 2255 SRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESEL 2314
L + + +Q + L+G + + + TR +Y + +L +LE+++
Sbjct: 2231 EILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTR-MY---ETKLKELETDI 2286
Query: 2315 KSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASREL-TSRL 2373
+TDL +++ E++ + E I+ K E ET+ REL RL
Sbjct: 2287 AKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRL 2346
Query: 2374 --HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEEN 2431
H+ K + I + + K+++ + Q ++IK+LE L + E L+EE
Sbjct: 2347 ANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEI 2406
Query: 2432 KKAVDKTNQL-------METLKTIKKENIQQKAQLDSFVKSMS 2467
KK + +E LK KE +++ L+ VK +S
Sbjct: 2407 KKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLS 2449
Score = 246 bits (628), Expect = 3e-64
Identities = 499/2653 (18%), Positives = 1081/2653 (40%), Gaps = 518/2653 (19%)
Query: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784
+ E K N +++ ++ +Q EL++ +A +Q + + +L+
Sbjct: 37 VNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLEN 96
Query: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844
E + A + L E + ++E EL+D++ + ++ + L + + E
Sbjct: 97 ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE 156
Query: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904
+E + + + K E+L Q + + +I + LL ++ + + + +K
Sbjct: 157 NENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKK----- 211
Query: 905 EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
N E EI+TL E + + ++ +EE + + Y+
Sbjct: 212 -------------NYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYN 258
Query: 965 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELAN-LKDES 1023
M + + + D LKKEN+ + ++Q EL + LK ++
Sbjct: 259 RM----KAIVHQTDNVIDQLKKENDHYQLQVQ------------------ELTDLLKSKN 296
Query: 1024 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEK 1083
+++ P+ +VEE K ++SK EI +E Q + +L EK
Sbjct: 297 EEDDPIMVAVNAKVEEWK-------LILSSKDDEI------------IEYQQMLHNLREK 337
Query: 1084 L--AAEEQFQALVKQMNQTLQDKTNQIDLL-------QAEISENQAIIQKLITSNTDASD 1134
L A + ++ V + Q +Q++ +QI +L E+ +N II+ L N +
Sbjct: 338 LKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDL--KNELQRN 395
Query: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKA 1194
+ L ++T H K ++ + L++K +EA + + A
Sbjct: 396 KGASTLSQQT------------HMK---------IQSTLDILKEKTKEAERTAELAEADA 434
Query: 1195 QEKERHLREELKQQKD-------------DYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241
+EK++ L E LK+ KD + + Q + +E E + ++ +L++++
Sbjct: 435 REKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKIS 494
Query: 1242 ESIDGKLPSTDQQESCSSTPGLE-EPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQG 1300
+ + D+ E+ GLE + + TE +++ + + +E+ L+
Sbjct: 495 DFL-------DENEALRERVGLEPKTMIDLTEFRNSKHLKQQQY------RAENQILLK- 540
Query: 1301 GTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVS 1360
+++ +E E+++L+ K+ E K+S GL E L
Sbjct: 541 ---------EIESLEEERLDLKKKIRQMAQERGKRSA----------TSGLTTEDLNLTE 581
Query: 1361 HEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEA 1420
+ ++ ++ +L + L+++ E Q K + +LS +L EKE
Sbjct: 582 NISQ------GDRISERKLDLLSLKNMSEAQSKNE--------------FLSRELIEKER 621
Query: 1421 ALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEES----- 1475
L + +T I + ++ +K +L + K+ +E +K++ + EM++ P+ G E+
Sbjct: 622 DLERSRTVIAKFQNKLK----ELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIP 677
Query: 1476 ---RAKQQIQRKLQAALISRKEALK--------ENKSLQEELSLARGTIERLTKSLADVE 1524
R I+ K + LK N+ L++EL +R ++ LA +
Sbjct: 678 SLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLA--K 735
Query: 1525 SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
+ + + EK+T L R + K I D + S+ +S + L E+KE
Sbjct: 736 ANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795
Query: 1585 KLVKEIES------------------LKSSKIAESTEWQEKHKELQKEYEILLQSYENVS 1626
K +K +E L ++E W+ + K +++E L + +
Sbjct: 796 KKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDA 855
Query: 1627 NEAERIQHVVEAVRQEKQELYGKLRSTEANKKET-----EKQLQEAEQEMEEMKEKMRKF 1681
+ + +++ A++ + E+ K E ++K T EK L + E++ ++RK
Sbjct: 856 IKVKEYNNLLNALQMDSDEM--KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKE 913
Query: 1682 AKSKQQKILELEEENDRLRAEVHPAGDTA--KECMETLLSSNASMKEELERVKMEYETLS 1739
+ ++ ++L +E E + + A K + N+ ELE +Y L+
Sbjct: 914 NEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELT 973
Query: 1740 KKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE 1799
K++ ++ + + L + +L+H N+S + +E+ K + +T+E +I E+
Sbjct: 974 AKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINK---ELEITKEKLHTIEQAWEQ 1030
Query: 1800 QDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKN 1859
+ L + S+ AK + ++ +I + ++I L+ + E +++
Sbjct: 1031 ETKLGNES------SMDKAKKS--------ITNSDIVSISKKITMLEMK----ELNERQR 1072
Query: 1860 KEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNL----LNQQIQEELS--------- 1906
E Q + T L Q+ ++ EL+ E+TK+NL + Q +++EL+
Sbjct: 1073 AEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSD 1132
Query: 1907 ----RVTKLKETAEEEKDDLEE-RLMNQLAELNGSIGNYCQDVTDAQIKN---ELLESEM 1958
R+ +L++ E K ++ + R ++ +A I N Q D ++++ +LL+ +
Sbjct: 1133 ADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
Query: 1959 KN--------------------------LKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
++ L+ S+L++ + ++ + K++ + + Y
Sbjct: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYA 1252
Query: 1993 KIQGAQKEPGNKSHAKELQE----LLKEKQQE-----VKQLQKDCIRYQEKISALERTVK 2043
+++G + + + L+ L QQE + QLQ D ++ +++ ++ +
Sbjct: 1253 RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHR 1312
Query: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKK 2103
+E E + L+ E L ++ K AQ KV+ + E R+ LKL +
Sbjct: 1313 NMENKTLEMELKLK-GLEELISTLKDTKGAQ------KVINWHMKIEELRL--QELKLNR 1363
Query: 2104 ELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ 2163
EL +KE +K + + ER + EE+ +++ K +E+ A + +V LE +
Sbjct: 1364 ELVKDKEEIK-YLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFD 1422
Query: 2164 VTLNKKDKEVQQLQENLDSTVTQLAAFTKSMS-SLQDDRD--RVIDEAKKWERKFSDAIQ 2220
N+ Q+ +E S + +L+ ++ R+I E + + + ++
Sbjct: 1423 RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLK 1482
Query: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHM------EELKINISRLEHD-------KQIWESK 2267
KE +RL E N + ++ + + E+L + R E + K ++
Sbjct: 1483 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTI 1542
Query: 2268 AQTEVQLQQK---------VCDTLQGENKELLSQLEETRHLYH--------SSQNE---- 2306
A + +L QK + + + E +E++ + EE H+ H SS N+
Sbjct: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT 1602
Query: 2307 ---------------------------LAKLESELKSLKDQLTDLSNSLEKCKE------ 2333
+A+ + L SL +L +S LE+ +E
Sbjct: 1603 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 1662
Query: 2334 ---------QKGNLEGIIRQQEADIQNSKFSYEQ-------LETDLQASRELTSRLHEEI 2377
+ N E +++ +A++++ K+ +Q L+++LQA +E SR
Sbjct: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTT 1722
Query: 2378 --NMKE--QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK 2433
N+ E + ++L +++A+ A+ ELR + +E + ++E ++ +++
Sbjct: 1723 MRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ---- 1778
Query: 2434 AVDK-TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIIL 2492
VD+ T +L ++ + + ++ K L + +SL ++ + + + Q+ ++ + I+
Sbjct: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838
Query: 2493 EKDQLIQEAAAENNKLKEEIRGL-------------RSHMDDLNSENAKLDAELIQYRED 2539
EK+++ Q EN++LK +I+ L +S +++L + KL+ +L E
Sbjct: 1839 EKEEIDQ----ENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQL----EG 1890
Query: 2540 LNQVITIKDSQQKQLLE--VQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE-- 2595
+ + +K ++K E ++ ++ K+ + K + KLKE E L + N L++
Sbjct: 1891 KVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLF 1950
Query: 2596 -----EKQDLSKEIESLKVSISQL----------------------------TRQVTALQ 2622
EK L +++++ +++ Q+ R AL
Sbjct: 1951 AKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALP 2010
Query: 2623 EEGTLGLYHAQLKVKEEEVHRLSALFSS---SQKRIAELEEELVC-----VQKEAAKKVG 2674
+ + H Q + +E++H L FS S+ I+ +E + C +QKE K
Sbjct: 2011 RDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSS 2070
Query: 2675 EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734
E +LK +L+ + D ++N+ +E L ++ E+++KL ++
Sbjct: 2071 E-NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKL-----------GHVR 2118
Query: 2735 SFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE-QGLLNRERDALLSETAFSMN 2793
GRS ++ + + +K+ + +E QLK+ G+L E+ A + + +
Sbjct: 2119 GSGRSGKTI----PELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLK 2174
Query: 2794 STEENSLSHL-EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL--WN 2850
+ E +HL +L+ SK + + ++ E +++ + A L+ +++L N
Sbjct: 2175 AELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILN 2234
Query: 2851 ELEKFRKSEEGKQRSAAQ---PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQI 2907
E + E GK+ A+ P A+ +S K + + + +LK L+ +
Sbjct: 2235 EKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE-----TKLKELETDIAKK 2289
Query: 2908 NQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMK 2967
NQ IT+L L + E + K + E+L Q+ +H + E
Sbjct: 2290 NQSITDLKQLVKEATEREQKVNKY---NEDLEQQIKILKH-------------VPEGAET 2333
Query: 2968 EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYET 3027
EQ L+ ++ LR ++ Q K + Q E + G+++ + +
Sbjct: 2334 EQ-------------GLKRELQVLRLANHQLDKEKAELIHQI--EANKDQSGAESTIPDA 2378
Query: 3028 ELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLL 3087
+ L+ ++ D ++ +L Q L +L +E + + L+ N Y + +
Sbjct: 2379 DQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN---YKEEV 2435
Query: 3088 NHCAVLEKQVQEL 3100
+LE++V++L
Sbjct: 2436 KKNILLEEKVKKL 2448
Score = 109 bits (272), Expect = 5e-23
Identities = 198/976 (20%), Positives = 414/976 (42%), Gaps = 146/976 (14%)
Query: 53 RLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIE 112
RLA EQ V E D + V+L++ + L+ +R+ + K+K+ E
Sbjct: 1622 RLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKE---------------FE 1666
Query: 113 EMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL-TQAQ 171
+K Q H+ + + E+E +K+ L + ++ L+++L Q +
Sbjct: 1667 NIKLQ-------------LQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKE 1713
Query: 172 AEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVR 231
A A ++T +K QL KE+ L L + +AE A R A + +
Sbjct: 1714 ANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAH 1773
Query: 232 LHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQI 291
L+ +++ T R L+ ++E+ E+L+ + + + +
Sbjct: 1774 LNVQQIVDRHT------------RELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLND 1821
Query: 292 LSQQLQQMEAEHN-TLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE 350
L+ +LQ+ + +N LR E ++E ++ K +++ L L + L+E+ +
Sbjct: 1822 LNNELQKKQKAYNKILREKEEIDQENDEL---KRQIKRLTSGLQGKPLTDNKQSLIEELQ 1878
Query: 351 -QAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDK 409
+ + + +LE + ++ K E K L + G++ Q+ + ++++ L++K
Sbjct: 1879 RKVKKLENQLEGKVEEVDLKPMKEKNAKEE--LIRWEEGKKWQAKIEGIRNK----LKEK 1932
Query: 410 NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV-TEE 468
+ + + L+D + KE +L LQ+ + + V G +A+ +E+
Sbjct: 1933 EGEVFTLTKQLNTLKDLFAKADKE------KLTLQRKLKTTGMTVDQVL--GIRALESEK 1984
Query: 469 NIASLQKRVVELENE------KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ L+KR ++LEN+ AL S+ +E+L +N L ++ LE Q
Sbjct: 1985 ELEELKKRNLDLENDILYMRAHQALPRDSV-VEDLHLQNRYLQEKLHALEKQFSK----- 2038
Query: 523 EVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQG 582
D +K S S ES + Q+ +EL L++ E+ F +L+
Sbjct: 2039 --------DTYSKPSISGIES------DDHCQREQELQKENLKLSSENIELKF-QLEQAN 2083
Query: 583 KRAEEADHEVLDQKEMKQMEGEGIAPIKMKV-FLEDTGQDFPLMPNEESSLPAVEKEQAS 641
K ++V D KEM + + A ++ K+ + +G+ +P E ++ ++K
Sbjct: 2084 KDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEK 2143
Query: 642 TEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFH 701
+ ++ ++ S ++ + +Q+ +K + ELE+LK+ L +L+ H
Sbjct: 2144 VQRENEQLKKASGILTSEKMANIEQENEKL-----------KAELEKLKAH-LGHQLSMH 2191
Query: 702 KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTE 761
YE K I+ +L +E KK D ++ +++ ++L++ M +
Sbjct: 2192 -----YESKTKGTEKIIAENERLRKELKKETD--AAEKLRIAKNNLEILNE----KMTVQ 2240
Query: 762 LRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDD 821
L K+L+ AE+ + +S++ ++T E K K+++ ++ +
Sbjct: 2241 LEETGKRLQ--FAESRGPQLEGADSKSWKSIVVTRM-----YETKLKELETDIAKKNQSI 2293
Query: 822 VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQL 881
L +Q + + Q NK +E LE ++ + E Q L ++EL++ ++
Sbjct: 2294 TDL---KQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGL-KRELQVLRLANH 2349
Query: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRA 941
L+K++ E + Q KDQ E + +++ + +IK L+ QL +
Sbjct: 2350 QLDKEK-AELIHQIEANKDQSGAESTIPDADQLKE----------KIKDLETQLKMSDLE 2398
Query: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN---EQRKRKLQAA 998
++ KE++++ LK+ + P+ E+L++ + K+N E++ +KL
Sbjct: 2399 KQHLKEEIKK-------LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQ 2451
Query: 999 LINRKELLQRVSRLEE 1014
L EL V+ EE
Sbjct: 2452 L--GVELTSPVAASEE 2465
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 234 bits (598), Expect = 8e-61
Identities = 388/1872 (20%), Positives = 790/1872 (42%), Gaps = 241/1872 (12%)
Query: 1044 KEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD 1103
+E + S+ +EIE SE E L+ + DLEEK A E +KQ + + ++
Sbjct: 43 EEVEAELPDSRTKEIEAIHAILRSENE-RLKKLCTDLEEKHEASE---IQIKQQSTSYRN 98
Query: 1104 KTNQIDLLQAEISENQAIIQ-KLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162
+ Q ++ + + Q +Q +L+ + A S A V T S G S H
Sbjct: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
Query: 1163 EEK-----ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE 1217
++ I++ ++E +L ++ L+ RH+ + K Q D + E
Sbjct: 159 DDDMDFGDIISSQQEINRLSNEVSR--------LESEVGHWRHIAQTSKAQGTDNSDQSE 210
Query: 1218 QFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQ 1277
Q NI +L+Q + Q ID D Q S + + H +
Sbjct: 211 ICKLQ-----NIIKELKQNRSQ---EID------DHQHEMSVLQNAHQQKLTEISRRHRE 256
Query: 1278 PVLESNLCPDWPSHSEDASAL--QGGTSVAQIKAQLKEI-EAEKVELELKVSSTTSELTK 1334
+ D+ E+ L QGG+ V I+ L +I E +K L++ S TK
Sbjct: 257 EL------SDYEERIEELENLLQQGGSGV--IETDLSKIYEMQKTIQVLQIEKVES--TK 306
Query: 1335 KSEEVFQLQEQINKQGLEIES----LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL 1390
K E++ + INK+ E+ L+ + V + ++ E+ +L+ + L+
Sbjct: 307 KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK 366
Query: 1391 QPK-LDELQKLISKKE--EDVSYLSGQLSEKE---AALTKIQTEIIEQEDLIKALHTQLE 1444
Q + E ++++++ E+V L LS+ E L+ + + ED +K L ++E
Sbjct: 367 QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLK-LKMRIE 425
Query: 1445 MQAKEHD---ERIKQLQVELCEMKQKPEEIGEESRAK-------QQIQRKLQAALISRKE 1494
+ KE + ++LQ+ L ++ + E I + ++ L+A +
Sbjct: 426 VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQ 485
Query: 1495 ALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITE 1554
++ E ++L E+ + TK + ++ Q+S Q E D+++ +L + K + +
Sbjct: 486 SISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 545
Query: 1555 MDRSLLE-NQSLSSSCESL---KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE 1610
++ ++ + L E L ++AL L K+KL ++E+L + + + QE +
Sbjct: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL----VDQLNKSQESNVS 601
Query: 1611 LQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE-KQLQEAEQ 1669
+QKE L + E RI++ E ++ Q+ + T ++E E + L++
Sbjct: 602 IQKENLELKEHIRQNEEELSRIRN--ELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLS 659
Query: 1670 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECM--------------E 1715
E+E++ E ++K A +++ EN++L +EC+ E
Sbjct: 660 ELEQLNENLKKVA-------FDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVE 712
Query: 1716 TLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQ-DLKHQIEGNVSKQ 1770
TL ++ EL +R+ E K + L + ++ + +Q + +H I+ N K
Sbjct: 713 TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 772
Query: 1771 ANLEATEKHDNQTNVTEEGTQSIPGET-EEQDSLS--MSTRPTCSESVPSAKSANPAVSK 1827
+ +K+ Q + + T+ + + EEQ L+ ++ + E + S
Sbjct: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832
Query: 1828 DFSSHDEINNYLQQIDQLKERIAG-LEEEKQKNKEFSQTLENEKNTLLSQISTKD-GELK 1885
+S N L+Q + K+R G ++EE +E + L E++ K +
Sbjct: 833 KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT 892
Query: 1886 MLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ-DV 1944
L EV+++N + + ++EE+ K+ E + K L + L Q E++ + Q +
Sbjct: 893 ELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNA 952
Query: 1945 TDAQI---KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEP 2001
T Q+ K+E ++S K +++ ++L EE+Q + + + + E + + L G++K
Sbjct: 953 THTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHD 1012
Query: 2002 GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061
+K+ + L + +KE++ E+K L + I ++I L + + + Q QKDLEI
Sbjct: 1013 LSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD-EVGKLTQIIQQKDLEI--- 1068
Query: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2121
QA+ R + + L Q+ A L ++ + N +K++ K
Sbjct: 1069 ---QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSH-LKTEY-HKMM 1123
Query: 2122 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181
D+ E A K E K + + ++ ++ ETI + + +KD E+ L +
Sbjct: 1124 DIVAAKEAALIKLQDENKKLSTRFESSGQDM--FRETIQNLSRIIREKDIEIDALSQKCQ 1181
Query: 2182 STVTQL----------AAFTKSMSSLQDDRDRVIDEAKK---WERKFSDAIQSKEEEIRL 2228
+ + L + L +RD++ + KK W+++ +Q+ + E
Sbjct: 1182 TLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQ 1241
Query: 2229 KEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK----AQTEVQLQQKV---CDT 2281
++ L+ Q+ S + +L+++ + L + E+K Q Q+Q + C+T
Sbjct: 1242 LQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNT 1301
Query: 2282 ---LQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338
L G+ + QL L S L +SE+ LS S E +++ L
Sbjct: 1302 KDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV---------LSESSELLQQELEEL 1352
Query: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
+++++A I+ + + +L + A+ EL + HE+ + + I L K++ +Q
Sbjct: 1353 RKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSE----IKQLKEKQDVLQKL 1408
Query: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458
+ E ++LL + + + ++ EN N+L+ T KE I
Sbjct: 1409 LKE------------KDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL---- 1452
Query: 2459 LDSFVKSMSSLQNDRDRIV-------GDYQQLEERHLS---IILEKD----QLIQEAAAE 2504
+ L+ + ++IV +YQ L+E ++ ++ EK+ + ++A A
Sbjct: 1453 --ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAF 1510
Query: 2505 NNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE 2564
LKE+ +G ++ L + + + + ++++ +QV+ +QKQ+ +N
Sbjct: 1511 EQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA--LKQKQM------ENTA 1562
Query: 2565 LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
L+N+ +L +K +N++L R N L E + ++E + + ++L ++VT L+E+
Sbjct: 1563 LQNEVQRLRDK---EFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEK 1619
Query: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE------LVCVQKEAAKKVGEIED 2678
+ E H+ S S Q+++ + ++ + V +E K+
Sbjct: 1620 -----LVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLA 1674
Query: 2679 KLKKELKHLHHDAGIMRN-ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737
L+ L+H + M + E E ++ +AE ++ +E K++
Sbjct: 1675 NLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVI----------------- 1717
Query: 2738 RSMSSLQNSRDHANEELDELKR---KYDASLKELAQLKEQGLLNRERDALLSETAFSMNS 2794
SLQ D AN LD R + D +++ +LK Q N R +L + + S
Sbjct: 1718 ----SLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQ---NELRQEMLDDVQKKLMS 1770
Query: 2795 TEENSLSHLEKL 2806
+S ++K+
Sbjct: 1771 LANSSEGKVDKV 1782
Score = 220 bits (560), Expect = 2e-56
Identities = 402/1935 (20%), Positives = 787/1935 (40%), Gaps = 311/1935 (16%)
Query: 351 QAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL----- 405
Q G + A L + S + E E+ L +T +E+++ L+ +N +L
Sbjct: 18 QVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRT-KEIEAIHAILRSENERLKKLCT 76
Query: 406 -LQDKNEQA-VQSAQTIQQLEDQLQQKSKEISQFLNR-LPLQQHETASQTSFPDVYN-EG 461
L++K+E + +Q Q +QLQQK EIS R + LQ Q++ V + G
Sbjct: 77 DLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAG 136
Query: 462 TQAVTEEN-----IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT----LLE 512
A T + I+ + + + G ++ S E+ L E +L S++ + +
Sbjct: 137 VPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQ 196
Query: 513 AQNRTGEADREVSEIS-----IVDIANKRSSSAEESGQD--VLENTFSQKHKELSVLLLE 565
G + + SEI I ++ RS ++ + VL+N QK E+S
Sbjct: 197 TSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEIS----- 251
Query: 566 MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLM 625
+ +EE++ + +R EE ++ + Q G G+ + E
Sbjct: 252 -RRHREELSDYE-----ERIEELEN-------LLQQGGSGVIETDLSKIYE--------- 289
Query: 626 PNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDE 685
+ ++ ++ E+ + + E+ + D +L S + D D I + Q++
Sbjct: 290 --MQKTIQVLQIEKVESTKKMEQLED-KIKDINKKLSSAENDRD--------ILRREQEQ 338
Query: 686 LERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE 745
L K QI+E E NL + + +A S T E
Sbjct: 339 LNVEKRQIME---------------------ECENLKLECSKLQPSAVKQSDTMT----E 373
Query: 746 RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEA 805
++++L+Q + V L+ + E E R L+ ++ A DNL +
Sbjct: 374 KERILAQSASVEEVFRLQQALSDAEN---EIMRLSSLNQDNSLAEDNLKLK--------- 421
Query: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
++IEVL+ E L E+ L SL +L N+ + A R + S++ +L
Sbjct: 422 ----MRIEVLEKEKS---LLSQEKEELQMSLL-KLNNEYEVIKSTATRDISLDSELHDLR 473
Query: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLG 925
L KE E+ +Q + EK ETL IEE D+Q E + M QL++++
Sbjct: 474 LNLEAKEQEL---NQSISEK----ETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGD 526
Query: 926 VEIKTLKEQLNLLSRAEEAKKEQVEEDN-EVSSGLKQNYDEMSPAG------QISKEELQ 978
I LK+ LN E+ + Q+E+D +++ L +++ + ++K++L+
Sbjct: 527 SIISKLKQDLN----DEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLE 582
Query: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI----------P 1028
+ + L + + + + EL + + + EEEL+ +++E + +
Sbjct: 583 DKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642
Query: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEE 1088
L + EV K+N E+ + +++ +K + + + +R LEE LA
Sbjct: 643 LLKEREAEVRNLKQNLSELEQ-LNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNN 701
Query: 1089 QFQALVKQMNQTLQDKTNQIDL----LQAEISENQAIIQKLITSNTDASDGDSVALVKE- 1143
Q + +TL+ + +I+ + + E +K I ++A + ++ AL E
Sbjct: 702 QLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEH 761
Query: 1144 --TVVISPPCTGSSEHWKPELEEKILALEKEKEQL------QKKLQEALTSRKAILKKAQ 1195
+ ++ K +E+ ++ K+ L QK+L + + ++ ++K +
Sbjct: 762 EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLK 821
Query: 1196 EKERHLREELKQQKDDYNR---LQEQFDEQSK-------ENENIGDQLRQLQIQVRESID 1245
E+ L+EEL + + L++ +E+ + EN ++ ++L +L RE
Sbjct: 822 ERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL----REEQS 877
Query: 1246 GKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVA 1305
P D + S T E T + H + ++ + + LQ
Sbjct: 878 RTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQ------ 931
Query: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ---EQINKQ-GLEIESLKT--- 1358
++ Q KE++ + + E ++ T +K EE+ LQ EQI Q E + ++T
Sbjct: 932 SLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNS 991
Query: 1359 -VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
+ E +V + +++ E L A E L + + + KL+++K ++ QLS+
Sbjct: 992 DIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSK 1051
Query: 1418 KEAALTKIQTEIIEQEDL-IKALHTQLEMQAKEHDERIKQLQVELCEMKQKP------EE 1470
E T+II+Q+DL I+ALH ++ + D Q Q++ M+++ E+
Sbjct: 1052 DEVGKL---TQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEK 1108
Query: 1471 IGEESRAKQQIQRKLQAALISRKEAL-----KENKSLQEEL-----SLARGTIERLTKSL 1520
E S K + + + +++ KEA ENK L + R TI+ L++ +
Sbjct: 1109 TRENSHLKTEYHKMMD--IVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRII 1166
Query: 1521 ADVESQVSAQNKEKDTVLGRL----------ALLQEERDKLITEMDRSLLENQSLSSSCE 1570
+ + ++ A +++ T+L L + + ++L+ E D+ + + + +
Sbjct: 1167 REKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQ 1226
Query: 1571 SLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYE------- 1623
+ ++ + + +L +E+ L++ + +S + + +LQ +Y L+QSYE
Sbjct: 1227 QVMTTVQNMQHESAQLQEELHQLQAQVLVDS----DNNSKLQVDYTGLIQSYEQNETKLK 1282
Query: 1624 NVSNEAERIQHVVEAVRQEKQELYGKL---------------RSTEANKKETEKQLQEAE 1668
N E ++QH + + K L GKL +S E + + L E+
Sbjct: 1283 NFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
Query: 1669 QEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL 1728
+ +++ E++RK + K I L+E N RL +++ +++ ++E
Sbjct: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRL--------------SDSIAATSELERKEH 1388
Query: 1729 ERVKMEYETLSKK---FQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV 1785
E+ E + L +K Q L+ EKD L + D L + E N+ N
Sbjct: 1389 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSD------------QLLSSNENFTNKVNE 1436
Query: 1786 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID-- 1843
E Q++ E L M + K N + + + + LQ+ +
Sbjct: 1437 NELLRQAVTNLKERILILEM--------DIGKLKGENEKIVETYRGKETEYQALQETNMK 1488
Query: 1844 ---QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
L+E+ K+K F Q L+ ++ K GEL L V M
Sbjct: 1489 FSMMLREKEFECHSMKEKALAFEQLLKEKE-------QGKTGELNQLLNAVKSMQEKTVV 1541
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
Q+E +V A ++K L N++ L Q++ +++N LLESE
Sbjct: 1542 FQQERDQVM----LALKQKQMENTALQNEVQRLRDKEFRSNQEL--ERLRNHLLESEDSY 1595
Query: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
++ ++ E+ + +L K+ T +E EK+ + N SH +Q ++Q
Sbjct: 1596 TREALA-AEDREAKLRKKVTVLE--------EKLVSSSNAMENASHQASVQVESLQEQLN 1646
Query: 2021 VKQLQKDCIRYQEKIS---------ALERTVKALEFVQTESQKDLEITKENLAQAVEHRK 2071
V Q+D Q +S +L LE Q E + E Q + K
Sbjct: 1647 VVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWK 1706
Query: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE 2131
K L + L + EA L +L ++L +E ++ ++K+++E + L+ +
Sbjct: 1707 KNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIE-ELKRQNELRQEMLDDVQ 1765
Query: 2132 EKHLKEKKNMQEKLD 2146
+K + + + K+D
Sbjct: 1766 KKLMSLANSSEGKVD 1780
Score = 208 bits (529), Expect = 8e-53
Identities = 372/1749 (21%), Positives = 748/1749 (42%), Gaps = 269/1749 (15%)
Query: 1411 LSGQLSEKEAALTKIQTEIIEQE------DLIKALHTQLEMQAKEHDERIKQLQVELCEM 1464
L+GQ+S + TE +E E I+A+H L + +ER+K+L +L E
Sbjct: 26 LTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAIL----RSENERLKKLCTDLEEK 81
Query: 1465 KQKPE-EIGEESRA-KQQIQRK------LQAALISRKEALKENKSLQEELSLARGT-IER 1515
+ E +I ++S + + Q+Q+K L+A I+ ++ L + +S + + G
Sbjct: 82 HEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATT 141
Query: 1516 LTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLE-------------- 1561
+ S A S + + D G + Q+E ++L E+ R E
Sbjct: 142 ASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQ 201
Query: 1562 ---NQSLSSSCESLKLALEGLTEDKEKLVK----EIESLKSSKIAESTEWQEKHKELQKE 1614
N S C+ L+ ++ L +++ + + E+ L+++ + TE +H+E +
Sbjct: 202 GTDNSDQSEICK-LQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSD 260
Query: 1615 YEILLQSYENVSNEAE------------RIQHVVEAVRQEKQELYGKLRSTEANKKETEK 1662
YE ++ EN+ + +Q ++ ++ EK E K+ E K+ K
Sbjct: 261 YEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINK 320
Query: 1663 QLQEAEQEMEEMKEKMRKFAKSKQQKILELEE---ENDRLRAEVHPAGDTAKECMETLLS 1719
+L AE + + ++ + + K+Q + E E E +L+ DT E E +L+
Sbjct: 321 KLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTE-KERILA 379
Query: 1720 SNASMKEELE-----------------------------RVKMEYETLSKKFQSLMSEKD 1750
+AS++E ++KM E L K+ L EK+
Sbjct: 380 QSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKE 439
Query: 1751 SLSEEVQDLKHQ---IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMST 1807
L + L ++ I+ ++ +L++ E HD + N+ E Q + E+++L
Sbjct: 440 ELQMSLLKLNNEYEVIKSTATRDISLDS-ELHDLRLNL-EAKEQELNQSISEKETLIAEI 497
Query: 1808 RPTCSESVPSAKSA---NPAVSKDFSSHDEINNYLQQ-IDQLKERIAGLEEEKQKNKEFS 1863
++ + K +SK + D I + L+Q ++ K+R+ LE++K + +
Sbjct: 498 EELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKM---DIT 554
Query: 1864 QTLENEKNTLL-SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE--EEKD 1920
+ L+ +K L+ S+++ D L + E NL++Q + + S V+ KE E E
Sbjct: 555 KELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIR 614
Query: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL---ESEMKNLKKCVSELEEEKQQLVK 1977
EE L EL S+ QD +++ K+ LL E+E++NLK+ +SELE+ + L K
Sbjct: 615 QNEEELSRIRNELMQSLN---QD-SNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKK 670
Query: 1978 EKTKVESEIRKEYL--EKIQGAQKE--PGNKSHAKELQELLKEKQQEVKQLQKDCI---- 2029
V+ E K L E ++ +E GN + E +++ + E +++ +
Sbjct: 671 VAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK 730
Query: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089
R E+ + E+T++ L + + L++ E+L + + + AEL +D
Sbjct: 731 RLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHK 790
Query: 2090 EAARVLADNLKLKKELQ---SNKESVKSQMKQKDEDLERRLE---QAEEKHLKEKKNMQE 2143
E VL+ +L+ +K+L + KE ++K++ L+ L+ QA K+ ++ ++E
Sbjct: 791 ETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEE 850
Query: 2144 K---LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
K L +++ E HL+E + ++ ++ + LDS VT+LA+ +S L
Sbjct: 851 KDRSLGSMKEENNHLQEELERLREEQSRTAPVADP--KTLDS-VTELAS---EVSQLNTI 904
Query: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIR-LKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
++ + +E K ++ D QSK + ++ L+E + + + + ++ ++ + + E
Sbjct: 905 KEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEE 964
Query: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE-ETRHLYHSSQ-NELAKLESE--LK 2315
K + ++ Q + QL ++ D +Q +N ++ + + ++ ++ + S+ ++L+K E+E +K
Sbjct: 965 IKSLQKTIEQIKTQLHEERQD-IQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
Query: 2316 SLKDQ------LTDLSNSLEK-----CKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364
+K++ L + + SL K K++ G L II+Q++ +IQ L
Sbjct: 1024 GIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQA-----------LH 1072
Query: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK---EIKELENLLSQEE 2421
A TS + + +++Q + + + E + + E +++ E ++ ++++ +E
Sbjct: 1073 ARISSTSHTQDVVYLQQQ--LQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKE 1130
Query: 2422 EENIVLEEENKK--------AVDKTNQLMETLKTIKKEN------IQQKAQLDSFVKSMS 2467
I L++ENKK D + ++ L I +E + QK Q V S
Sbjct: 1131 AALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTS 1190
Query: 2468 SLQND---------------RDRIVGDYQQLEERHLSIILEKDQLIQEAAA--------- 2503
S N+ RD++ +++EE ++ + E+A
Sbjct: 1191 STGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ 1250
Query: 2504 --------ENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQ----- 2550
N+KL+ + GL + ++ EL Q + + Q+ KD
Sbjct: 1251 AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD 1310
Query: 2551 --QKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLK 2608
QL L + E A E L ES E L++ L++ Q+ I +L+
Sbjct: 1311 IISPQLSSASLLTPQSAECLRASKSEVLSESSEL---LQQELEELRKSLQEKDATIRTLQ 1367
Query: 2609 VSISQLTRQVTALQE------EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL 2662
+ +L+ + A E E T +++K +E+ L L I ++L
Sbjct: 1368 ENNHRLSDSIAATSELERKEHEQT----DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
Query: 2663 VCVQKEAAKKVGEIE------DKLKKELKHLHHDAGIMRNETETAEERVAELARD---LV 2713
+ + KV E E LK+ + L D G ++ E E E + L
Sbjct: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQ 1483
Query: 2714 EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE-ELDELKRKYDASLKELAQLK 2772
E K M+ +E + ++ + L ++ EL++L L + ++
Sbjct: 1484 ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQL-------LNAVKSMQ 1536
Query: 2773 EQGLL-NRERDALLSETAFSMNSTEENSLSH-LEKLNQQLLSKDEQLLHLSSQL---EDS 2827
E+ ++ +ERD ++ A E +L + +++L + +++L L + L EDS
Sbjct: 1537 EKTVVFQQERDQVM--LALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDS 1594
Query: 2828 YNQVQSFSKAMASLQNE---RDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
Y + +A+A+ E R + EK S + ++ Q S +V+SL++ ++
Sbjct: 1595 YTR-----EALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASV---QVESLQEQLN 1646
Query: 2885 SLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA-FQIMQEELRQENL 2943
+ RD +L Q+ Q+ Q L L+ L+ +Q + KA + E+ +Q
Sbjct: 1647 VVSKQRDETALQLSVSQE---QVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIA 1703
Query: 2944 SWQHELHQL 2952
W+ L
Sbjct: 1704 EWKKNAENL 1712
Score = 196 bits (498), Expect = 3e-49
Identities = 357/1836 (19%), Positives = 770/1836 (41%), Gaps = 250/1836 (13%)
Query: 58 EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA---KLTSLNKYIEEM 114
++L +L++ ++Q++Q+ + + + + + +I LK A +L L + +
Sbjct: 72 KKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSV 131
Query: 115 KAQGGTVLPTEPQSEEQ-LSKHDKSSTEEEMEIEKIKHKLQEKEEL---ISTLQ------ 164
+ G T S +S H + +++M+ I QE L +S L+
Sbjct: 132 PSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHW 191
Query: 165 ---AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVRE 221
AQ ++AQ + S + ++K+ Q + + I Q ++S Q A QQ + E
Sbjct: 192 RHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQ--NAHQQKLTE 249
Query: 222 KDARFETQVRLHEDELLQL----------VTQADVET--EMQQKLRVLQRKLEEHEESLV 269
R ++ +E+ + +L V + D+ EMQ+ ++VLQ + E + +
Sbjct: 250 ISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKME 309
Query: 270 GRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVA 329
+ + ++L++AE IL ++ +Q+ E + + E E K+ K++
Sbjct: 310 QLEDKIKDINKKLSSAENDRDILRREQEQLNVE----KRQIMEECENLKLECSKLQPSAV 365
Query: 330 ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQ 389
++ + E +L Q A +E + + AE E I+ L Q
Sbjct: 366 KQS----DTMTEKERILAQ-------SASVEEVFRLQQALSDAENE-----IMRLSSLNQ 409
Query: 390 ELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETA 449
+ ++L + N KL + +++ + L Q+ +E+ L +L ++E
Sbjct: 410 D-----NSLAEDNLKL--------KMRIEVLEKEKSLLSQEKEELQMSLLKLN-NEYEVI 455
Query: 450 SQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT 509
T+ D+ + N+ + ++ + + +EK L+ E+EEL +N++ + +
Sbjct: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLI---AEIEELDRQNQEATKHMI 512
Query: 510 LLEAQ--NRTGEADREVSEI-SIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566
L++ Q + E D +S++ ++ KR E+ D+ + QK K +
Sbjct: 513 LIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLI------- 565
Query: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAP--IKMKVFLEDTGQDFPL 624
Q E+A L L ++ E+ ++DQ Q I +++K + ++
Sbjct: 566 ---QSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSR 622
Query: 625 MPNE--------------ESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670
+ NE ++ L E E + + E+++ N V K + +K
Sbjct: 623 IRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF-DVKMENEK 681
Query: 671 SLSAVPDIGQ------CHQDELERLKSQILE---LELNFHKAQEIYEKNLDEKAKEISNL 721
+ A D+ ++L K+ I+E +E +A+ + K +E +
Sbjct: 682 LVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK--RLLEEANKY 739
Query: 722 NQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRR 781
+ IEE NA N +++ L E L+Q K++ + EL+ ++Q++ + E +
Sbjct: 740 EKTIEEL-SNARNLNTSALQLEHEHLIKLNQKKDME-IAELKKNIEQMDTDHKETKDVLS 797
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ-- 839
E Q LT+ I+ I + + LQ ELD + L ++++ +
Sbjct: 798 SSLEEQ----KQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853
Query: 840 ----LQNKESEVLEGAERVRHISSKVEELS-----QALSQKELEITKMDQLLLEKKRDVE 890
++ + + + E ER+R S+ ++ ++++ E+++++ + + +++
Sbjct: 854 SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIK 913
Query: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKT-------LKEQLNLLSRAEE 943
Q+ IE+++Q ++ S+ E+ +++E ++ T E++ L + E
Sbjct: 914 HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
Query: 944 AKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQ-----RKRKLQAA 998
K Q+ E+ + + + + ++ E + DL K E E+ ++R+L+
Sbjct: 974 QIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIK 1033
Query: 999 LINRK--ELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQ 1056
L+N K L +++ +L KDE K + + + E++ ++ TS Q
Sbjct: 1034 LLNEKNISLTKQIDQLS------KDEVGKLTQIIQQKDLEIQ-----ALHARISSTSHTQ 1082
Query: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
++ +YL+Q + +E + + L EK + +M + K + LQ
Sbjct: 1083 DV-VYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ---D 1138
Query: 1117 ENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQL 1176
EN+ + + +S D + +ET+ + E + +I AL ++ + L
Sbjct: 1139 ENKKLSTRFESSGQD--------MFRETI-------QNLSRIIREKDIEIDALSQKCQTL 1183
Query: 1177 QKKLQEALTSRKAILKKAQEKERHL--REELKQQKDDYNRLQEQ----FDEQSKENENIG 1230
LQ + T +A + + E L R++LKQQ ++Q E+ +
Sbjct: 1184 LAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1243
Query: 1231 DQLRQLQIQVRESID----------GKLPSTDQQESCSSTPGLEEPLFKATEQH------ 1274
++L QLQ QV D G + S +Q E+ G E A QH
Sbjct: 1244 EELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE----LAQVQHSIGQLC 1299
Query: 1275 HTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTK 1334
+T+ +L L D S +++L S ++A E+ +E EL
Sbjct: 1300 NTKDLLLGKL--DIISPQLSSASLLTPQSAECLRASKSEVLSESSEL------------- 1344
Query: 1335 KSEEVFQLQEQINKQGLEIESLKTVSHEA--EVHAESLQQKLESSQLQIAGLEHLRELQP 1392
+E+ +L++ + ++ I +L+ +H + A S ++ E Q +++L+
Sbjct: 1345 LQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTD----SEIKQLKE 1400
Query: 1393 KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE 1452
K D LQKL+ +K+ + S QL T + + +L++ T L+ E
Sbjct: 1401 KQDVLQKLLKEKDLLIKAKSDQLLSSNENF----TNKVNENELLRQAVTNLK-------E 1449
Query: 1453 RIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGT 1512
RI L++++ ++K + E+I E R K+ + LQ + L+E + +
Sbjct: 1450 RILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALA 1509
Query: 1513 IERLTKSLADVES-QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES 1571
E+L K ++ +++ ++ + + Q+ERD+++ + + +EN +L + +
Sbjct: 1510 FEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQR 1569
Query: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ-------SYEN 1624
L+ ++ E+L + + S E+ +++ +L+K+ +L + + EN
Sbjct: 1570 LRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMEN 1629
Query: 1625 VSNEA----ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME--EMKEKM 1678
S++A E +Q + V +++ E +L ++ K+ L + +E + +EK
Sbjct: 1630 ASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKA 1689
Query: 1679 RKFAKSKQQK--ILELEEENDRLRAEVHPAGDTAKECME---TLLSSNASMKEELERVKM 1733
A+ ++QK I E ++ + L +V + +EC++ L S + + E+L+ +
Sbjct: 1690 MYSAELEKQKQLIAEWKKNAENLEGKV----ISLQECLDEANAALDSASRLTEQLDVKEE 1745
Query: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
+ E L ++ + D + +++ L + EG V K
Sbjct: 1746 QIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDK 1781
Score = 193 bits (491), Expect = 2e-48
Identities = 341/1709 (19%), Positives = 727/1709 (42%), Gaps = 259/1709 (15%)
Query: 1586 LVKEIESLKSSKIAESTEWQE------KHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
L +I + + E TE E + KE++ + IL E + ++
Sbjct: 26 LTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEE----- 80
Query: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699
+ E E+ K +ST QLQ+ E E+ +K + Q ++L+L+ +
Sbjct: 81 KHEASEIQIKQQSTSYRN-----QLQQKEVEISHLKARQIAL----QDQLLKLQSAAQSV 131
Query: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
+ TA +S + S + + + + ++ L +E L EV
Sbjct: 132 PSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHW 191
Query: 1760 KHQIEGNVSKQANLEATEKHDNQT-----NVTEEGTQSIPGETEE-QDSLSMSTRPTCSE 1813
+H +++ + + T+ D N+ +E Q+ E ++ Q +S+ +
Sbjct: 192 RH-----IAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQK 246
Query: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQ------------IDQLKERIAGLEEEKQKNKE 1861
++ +S +E+ N LQQ I ++++ I L+ EK ++ +
Sbjct: 247 LTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK 306
Query: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV----TKLKETAEE 1917
+ LE++ + ++S+ + + +L+ E ++N+ +QI EE + +KL+ +A +
Sbjct: 307 KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK 366
Query: 1918 EKDDL--EERLMNQLAELNGSIGNYCQDVTDAQIK----------NELLESEMKNLKKCV 1965
+ D + +ER++ Q A + + Q ++DA+ + N L E +K LK +
Sbjct: 367 QSDTMTEKERILAQSASVE-EVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLK-LKMRI 424
Query: 1966 SELEEEKQQLVKEKTKVESEIRK---EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 2022
LE+EK L +EK +++ + K EY A ++ S +L+ L+ K+QE+
Sbjct: 425 EVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELN 484
Query: 2023 QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKV 2082
Q I +E + A ++ L+ E+ K + + K+ L++ + + + ++ K
Sbjct: 485 Q----SISEKETLIA---EIEELDRQNQEATKHMILIKDQLSK---QQNEGDSIISKLKQ 534
Query: 2083 LLDDTQSEAARVLADNLKLKKELQSNKES-VKSQMKQKDEDL-ERRLEQAEEKHLKEKKN 2140
L+D + ++ D + + KEL KE ++S++ D L +++LE E + +
Sbjct: 535 DLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNK 594
Query: 2141 MQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
QE ++++E + L+E I + ++E+ +++ L M SL D
Sbjct: 595 SQESNVSIQKENLELKEHI-------RQNEEELSRIRNEL-------------MQSLNQD 634
Query: 2201 RDRVIDEAKKWERKFSDAI-QSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
+ F D + + +E E+R + N S +L Q++ +++++ ++ ++E+
Sbjct: 635 SNS----------NFKDTLLKEREAEVRNLKQNLS----ELEQLNENLKKVAFDV-KMEN 679
Query: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD 2319
+K + A +V+ Q + C L G N+ L E + + + E ++E+EL K
Sbjct: 680 EKLVL---ACEDVRHQLEEC--LAGNNQLSL----EKNTIVETLKMEKGEIEAELCWAKK 730
Query: 2320 QLTDLSNSLEKCKEQKGNLEGII---------------RQQEADIQNSKFSYEQLETDLQ 2364
+L + +N EK E+ N + ++++ +I K + EQ++TD +
Sbjct: 731 RLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHK 790
Query: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424
++++ S +++EQK ++ L K+E + E + +E+ + L + E
Sbjct: 791 ETKDVLSS-----SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILR 845
Query: 2425 IVLEEENKKA---VDKTNQLMETLKTIKKENIQQKAQLD-SFVKSMSSLQNDRDRIVGDY 2480
+EE+++ ++ N L E L+ +++E + D + S++ L ++ ++
Sbjct: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIK 905
Query: 2481 QQLEER---HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKL----DAEL 2533
+ LEE H II +++Q + + K+E+ R + +N+ + +L D E+
Sbjct: 906 EHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEI 965
Query: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
++ + Q+ T +++ + +E + + +E ++ + + + R +
Sbjct: 966 KSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGI 1025
Query: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQ- 2652
+E + EI+ L LT+Q+ L ++ +G ++ K+ E+ L A SS+
Sbjct: 1026 KEREL----EIKLLNEKNISLTKQIDQLSKD-EVGKLTQIIQQKDLEIQALHARISSTSH 1080
Query: 2653 -KRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
+ + L+++L E K + +K + E HL +T ++ ++
Sbjct: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTR-ENSHL-----------KTEYHKMMDI--- 1125
Query: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRSM--SSLQNSRDHANEELDELKRKYDASLKELA 2769
+ E L+ + ENK L+ + +S G+ M ++QN L + R+ D + L+
Sbjct: 1126 VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQN--------LSRIIREKDIEIDALS 1177
Query: 2770 QLKEQGLLNRERDALLSETAFSMNSTE-ENSLSHLEKLNQQLLSKDE----------QLL 2818
Q K Q LL + + A +NS + E L +KL QQ+ +E +
Sbjct: 1178 Q-KCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQ 1236
Query: 2819 HLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQS 2878
H S+QL++ +Q+Q+ + ++ + L + + E K ++ Q E+
Sbjct: 1237 HESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQ------ELAQ 1290
Query: 2879 LKKAMSSLQNDRDRLLKELKNLQQQY----LQINQEITELHPLKAQL---------QEYQ 2925
++ ++ L N +D LL +L + Q L Q L K+++ QE +
Sbjct: 1291 VQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELE 1350
Query: 2926 DKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQ 2985
+ K+ Q +R + Q H+L ++ ER+ EQ I ++ LQ
Sbjct: 1351 ELRKSLQEKDATIR----TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQ 1406
Query: 2986 NLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKE 3045
L++E K + S + +S + N V E ELLR + + + I E
Sbjct: 1407 KLLKE-----------KDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILE 1455
Query: 3046 LRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPL 3105
+ I +L +++E + Q+L+E + +L E + ++ L
Sbjct: 1456 MDIGKLKGENEKIVETYRGKETEY----QALQETNMKFSMMLRE---KEFECHSMKEKAL 1508
Query: 3106 NIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRV 3165
+ + L+E +Q + QL N + + E + ++ERDQ +
Sbjct: 1509 AFE------------------QLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVM 1550
Query: 3166 AA----ENALSVAEEQIRRLEHSEWDSSR 3190
A + + + +++RL E+ S++
Sbjct: 1551 LALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
Score = 75.1 bits (183), Expect = 1e-12
Identities = 96/459 (20%), Positives = 191/459 (41%), Gaps = 57/459 (12%)
Query: 1 MLSRLSGLANVVLHELSGD-DDTDQNMRAPLDPELHQESDM-----EFNNTTQEDVQERL 54
+LS S L L EL + D +R L H+ SD E E +
Sbjct: 1337 VLSESSELLQQELEELRKSLQEKDATIRT-LQENNHRLSDSIAATSELERKEHEQTDSEI 1395
Query: 55 AYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKL------HAKAKLTSLN 108
++ L+ ++++KD+ ++ K + L + NK+ + +L + K ++ L
Sbjct: 1396 KQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILE 1455
Query: 109 KYIEEMKAQGGTVLPTEPQSEEQLS-------KHDKSSTEEEMEIEKIKHKLQEKEELIS 161
I ++K + ++ T E + K E+E E +K K E+L+
Sbjct: 1456 MDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLK 1515
Query: 162 TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVRE 221
+ T + Q + M+E ++ QQ E+++ + L+ + + A Q Q +R+
Sbjct: 1516 EKEQGKT-GELNQLLNAVKSMQEKTVVFQQ--ERDQVMLALKQKQMENTALQNEVQRLRD 1572
Query: 222 KDARFETQVRLHEDELLQ--------LVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ 273
K+ R ++ + LL+ + D E ++++K+ VL+ KL ++
Sbjct: 1573 KEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAM----- 1627
Query: 274 VVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKL 333
E + S Q++ ++ + N V +R+E+ + L + +V + L
Sbjct: 1628 ------------ENASHQASVQVESLQEQ----LNVVSKQRDETALQLSVSQEQVKQYAL 1671
Query: 334 SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS 393
S NLQ + H Q E+ AELE + L + K E ++SLQ+ E +
Sbjct: 1672 SLANLQMVLEHF--QQEEKAMYSAELE-KQKQLIAEWKKNAENLEGKVISLQECLDEANA 1728
Query: 394 ACDALKDQNSKL--LQDKNEQAVQSAQTIQQLEDQLQQK 430
A D+ +L +++ E+ + + Q++ D +Q+K
Sbjct: 1729 ALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
Score = 70.1 bits (170), Expect = 3e-11
Identities = 118/563 (20%), Positives = 226/563 (40%), Gaps = 64/563 (11%)
Query: 22 TDQNMR---APLDPELHQES-----DMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV 73
T QNM+ A L ELHQ D + N+ Q D + EQ +LK+ ++
Sbjct: 1231 TVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE--- 1287
Query: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL- 132
L Q ++ + D + KL + + Q + PQS E L
Sbjct: 1288 -LAQVQHSIGQLCNTKDLLLGKLDI---------------ISPQLSSASLLTPQSAECLR 1331
Query: 133 -SKHDKSSTEEEM---EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM 188
SK + S E+ E+E+++ LQEK+ I TLQ + A S E +E
Sbjct: 1332 ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQT 1391
Query: 189 KQQLQEKEEFISTLQAQLSQTQAE-QAAQQVVREKDARFETQVRLHEDELLQLVTQADVE 247
++++ +E LQ L + +A + + F +V +E+ELL+
Sbjct: 1392 DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV--NENELLRQAV----- 1444
Query: 248 TEMQQKLRVLQR---KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 304
T +++++ +L+ KL+ E +V + + E A ++ N S L++ E E +
Sbjct: 1445 TNLKERILILEMDIGKLKGENEKIV---ETYRGKETEYQALQETNMKFSMMLREKEFECH 1501
Query: 305 TLRNTVET------EREESKI-----LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
+++ E+E+ K LL ++ + E+ + F ++++ L+Q +
Sbjct: 1502 SMKEKALAFEQLLKEKEQGKTGELNQLLNAVK-SMQEKTVVFQQERDQVMLALKQKQMEN 1560
Query: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQA 413
A R E + E+E +H+L + + A + + + K + E+
Sbjct: 1561 TALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL 1620
Query: 414 VQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD------VYNEGTQAVTE 467
V S+ ++ Q + + + + LN + Q+ ETA Q S + +
Sbjct: 1621 VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVL 1680
Query: 468 ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEI 527
E+ +K + E EK L++ + E + +S Q L EA A R ++
Sbjct: 1681 EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL 1740
Query: 528 SIVDIANKRSSSAEESGQDVLEN 550
+ + + E Q++L++
Sbjct: 1741 DVKEEQIEELKRQNELRQEMLDD 1763
Score = 37.4 bits (85), Expect = 0.24
Identities = 62/320 (19%), Positives = 127/320 (39%), Gaps = 34/320 (10%)
Query: 2877 QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE 2936
QSL + SL + L ++ N + L E E A+L + +TK + +
Sbjct: 14 QSLGQVGGSLAS----LTGQISNFTKDMLMEGTEEVE-----AELPD--SRTKEIEAIHA 62
Query: 2937 ELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSS 2996
LR EN + L + + EI ++ Y + K+ ++SHL + R +
Sbjct: 63 ILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHL-----KARQIAL 117
Query: 2997 QTQPLKVQYQRQASPETSASP--DGSQNLVYETELLRTQLND---SLKEIHQKELRIQQL 3051
Q Q LK+Q Q+ P + P S + Y + +D +I + I +L
Sbjct: 118 QDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRL 177
Query: 3052 NSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVL----EKQVQELQAGPLNI 3107
++ S+L E + TS++ + ++ ++ + + QE+ +
Sbjct: 178 SNEVSRLESEVGHWR-HIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEM 236
Query: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLC--------NTRQEVNELRKLLEE 3159
V A Q+K + EEL + ++ E + L ++ E++K ++
Sbjct: 237 SVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQV 296
Query: 3160 ERDQRVAAENALSVAEEQIR 3179
+ ++V + + E++I+
Sbjct: 297 LQIEKVESTKKMEQLEDKIK 316
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 229 bits (585), Expect = 3e-59
Identities = 674/3369 (20%), Positives = 1331/3369 (39%), Gaps = 614/3369 (18%)
Query: 68 IRQKDVQLQQKDEALQEERKAADNKIKKLKLHA-----------------KAKLTSLNKY 110
+R+K Q +++ EALQEE + A ++++ A K K+ +L +
Sbjct: 2134 LREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDW 2193
Query: 111 IEEMKAQGGTVLPTEPQSEE----QLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQ 166
+ + + GG +L P E+ L K +T+ M + + KL ++ E++ +
Sbjct: 2194 VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 2253
Query: 167 LTQAQ-----AEQPAQSSTEM-------EEFVMMKQQLQE-KEEFISTL---QAQLSQTQ 210
L Q A Q AQ+ + EE M++Q+L E KE++ ++L +A+L Q Q
Sbjct: 2254 LLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQ 2313
Query: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVG 270
Q Q + FE+ + E E L+ + + E L Q E S G
Sbjct: 2314 TLQDELQKFLQDHKEFESWLERSEKE-LENMHKGGSSPETLPSLLKRQGSFSEDVISHKG 2372
Query: 271 RAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI--LLEKMELEV 328
+ V + Q++ E N+ + +E S+I L++ +
Sbjct: 2373 DLRFVTISGQKVLDME---------------------NSFKEGKEPSEIGNLVKDKLKDA 2411
Query: 329 AERKLSFHN----LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSL 384
ER + H+ L ++ LL Q+ Q + L++ A E A +E+ S ++
Sbjct: 2412 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE----ANVEKLLSDTVAS 2467
Query: 385 QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ----FLNR 440
+ Q A + Q E+ + A+ I ++E + + + + L+
Sbjct: 2468 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH 2527
Query: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE---KGALLLSSIELEEL 497
+ A ++S +Q+V +E++ SL + + E+E K LSS ++E
Sbjct: 2528 FQSLSYSLAERSSLLQKAIAQSQSV-QESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEA 2586
Query: 498 KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHK 557
A N KL I Q + EA RE + F +
Sbjct: 2587 LATNMKLKQDIA---RQKSSLEATRE------------------------MVTRFMETAD 2619
Query: 558 ELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEM-KQMEGEGIAPIKMKVFLE 616
+ +L+ K A+ F +L LQ + E + ++L Q EM + + G K++ F+E
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSG------KLQQFME 2673
Query: 617 DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676
N+ L + + H + +E++L E++ +++ D V
Sbjct: 2674 ----------NKSRMLASGNQPDQDITHFFQQIQELNL-----EMEDQQENLDTLEHLVT 2718
Query: 677 DIGQC--------HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF 728
++ C HQD ++ L+ EL +K + E+ K+ S+ + ++EF
Sbjct: 2719 ELSSCGFALDLCQHQDRVQNLRKDFTEL-----------QKTVKEREKDASSCQEQLDEF 2767
Query: 729 KKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYE--- 785
+K F +E + + + EL Q++ L+ L + + L E
Sbjct: 2768 RKLV----RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINC 2823
Query: 786 SQTAHDNLLTEQIHSLSIEAKSKDVKIEV------------------LQNELDDVQLQFS 827
T+ +NL+ E I + + K+ + V +Q ++ DV L++
Sbjct: 2824 KGTSLENLIME-ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYE 2882
Query: 828 EQSTLIRSLQSQLQ---NKESEVLEGAERV-RHISSKVEEL----------------SQA 867
+ ++ Q LQ N+ EV + A V + + SK E L +QA
Sbjct: 2883 KLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQA 2942
Query: 868 LSQK----ELE-----ITKMDQLLL---------EKKRDVETLQQTIEEKDQQVTEISFS 909
S K ELE I K+ + L ++ + + +Q+ + + ++ TE++ +
Sbjct: 2943 ESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVA 3002
Query: 910 MTEKMVQ------------------LNEEKFSLGV---------EIKTLKEQLNLLSRAE 942
++ + L E++ +GV + K+Q+ + +
Sbjct: 3003 RQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEF 3062
Query: 943 EAKKEQVEEDNEVSSGLKQNYDEMS-PAGQISKE--ELQHEFDLLKKENEQRKRKLQAAL 999
EA+++Q E+ NE + G+ ++S Q+ KE + ++ L + R ++ A+
Sbjct: 3063 EARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 3122
Query: 1000 INR---KELLQRVS--------RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1048
+ +ELLQ +S RL + A + L ET E+ D E ++
Sbjct: 3123 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET--SEIRSDLEQLDHEV 3180
Query: 1049 KCVTSKCQEIEI-----YLK-------QTISEKEVELQHIRKD----LEEKLAAEEQFQA 1092
K + C E+ + YLK +T++ L+ + D L+ LA+ +QFQ
Sbjct: 3181 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 3240
Query: 1093 LVKQMNQTLQDKTNQ----------IDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142
+ ++ L DK +Q ++ LQ+++ EN+ + L N + + +
Sbjct: 3241 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSL---NQHSGSYEVIVAEG 3297
Query: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1202
E++++S P K L+ +++ L+ E+L KK + + K ++KAQ+ + H+
Sbjct: 3298 ESLLLSVP----PGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 3353
Query: 1203 E---ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ---QES 1256
+ ++ K + L+ D E+ + + +++ R S+ L S S
Sbjct: 3354 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSS 3413
Query: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
+ G+ + ++ + + + +E+ A G S+ ++ +L+E +
Sbjct: 3414 EADEDGIRDE--------------KAGINQNMDAVTEELQAKTG--SLEEMTQRLREFQE 3457
Query: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376
+E KV +L E+F + + Q ++L +KL +
Sbjct: 3458 SFKNIEKKVEGAKHQL-----EIF---DALGSQACSNKNL---------------EKLRA 3494
Query: 1377 SQLQIAGLEHLRELQPKLDELQKLISKKEEDV---SYLSGQLSEKEAALTKIQTEIIEQE 1433
Q E L+ L+P++D L+ ED S S L + E A Q E +E +
Sbjct: 3495 QQ------EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA----QQEFLEVK 3544
Query: 1434 DLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493
+ + +E + E I Q + EM + ++ +E I R
Sbjct: 3545 QRVNSGCVMMENKL----EGIGQFHCRVREMFSQLADLDDELDGMGAIGR---------- 3590
Query: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERD-KLI 1552
+ SLQ ++ R + ++ D+E+ A+ + G L LL +R+ + +
Sbjct: 3591 ----DTDSLQSQIEDVRLFLNKIHVLKLDIEAS-EAECRHMLEEEGTLDLLGLKRELEAL 3645
Query: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
+ L E E L+L L + + KL ++ +++ AE+ +W +
Sbjct: 3646 NKQCGKLTERGKARQ--EQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW-----VVG 3698
Query: 1613 KEYEILLQSYENVSN-EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEM 1671
E EI+ Q + + E++ + ++Q G ++S A K + +Q E +M
Sbjct: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS--AGK---DCDVQGLEHDM 3753
Query: 1672 EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
EE+ + K Q+I +L+E A +H ++ +E LLS A +E +
Sbjct: 3754 EEINARWNTLNKKVAQRIAQLQE------ALLHCG--KFQDALEPLLSWLADTEELIANQ 3805
Query: 1732 K---MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQ 1782
K EY+ + + Q E+ L + D K ++ G +++ A L EK Q
Sbjct: 3806 KPPSAEYKVVKAQIQ----EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3861
Query: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVS--KDFSSHDEINNYLQ 1840
+S+ E S + + + + + AK + DF S E L
Sbjct: 3862 -------LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE--KKLA 3912
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS--------TKDGELKMLQEEVT 1892
+ + + A ++++ ++K + +EN + + T E +L E++
Sbjct: 3913 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3972
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEE-----KDDLEERLMNQLAELNGSIG-----NYCQ 1942
+ +IQ+ R L + A +D++E ++N LAE+ + ++ Q
Sbjct: 3973 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE--VLNWLAEVEDKLSSVFVKDFKQ 4030
Query: 1943 DVTDAQIKNEL-LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEP 2001
DV Q + L L E+ N KK V + + Q L+K+ T E + +E L+
Sbjct: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLD--------- 4081
Query: 2002 GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061
G K+ ++ + + ++Q ++ ++Q L ++ +E + + T E
Sbjct: 4082 GIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVE-EELATSGGQSPTGE 4140
Query: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNL---------KLKKELQSNKESV 2112
+ Q + +K+ + E+ +++L DT +E +R L + + KL + + V
Sbjct: 4141 QIPQFQQRQKELKKEVMEHRLVL-DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 4199
Query: 2113 KSQMKQKDEDLE------RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQV-- 2164
+ Q+ ++++ ++ EQA + L + KL AL ++ ++T ++QV
Sbjct: 4200 SDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 4259
Query: 2165 -------------------------TLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
T ++ K V LQE +S + Q A +S L
Sbjct: 4260 AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTV--LQEKTESLIQQYEA----ISLLNS 4313
Query: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
+R ++ A+ +F + EE+ + L QL +I E+L+ + E
Sbjct: 4314 ERYARLERAQVLVNQFWETY----EELSPWIEETRALIAQLPSPAIDHEQLR---QQQEE 4366
Query: 2260 DKQIWESKAQTEVQLQQ--KVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK-- 2315
+Q+ ES A+ + + + K+ L+ N E +EE Y ++N A+++ E++
Sbjct: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK---YQKAENMYAQIKEEVRQR 4423
Query: 2316 --------SLKDQLTDLSNSLEKCKEQKGNLEGIIRQ-----QEAD-----IQNSKFSYE 2357
S Q+T+ + +E E NL +R E D I ++K +
Sbjct: 4424 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATV 4483
Query: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKE-------------------EAIQVA 2398
+LE LQ S E R EE+ + Q L+ KE E ++
Sbjct: 4484 ELE-KLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIK 4542
Query: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKT--NQLMETLKTIKKENIQQK 2456
++ + +K ++ LL+ ++ ++ + +D + Q +E +TIK+E
Sbjct: 4543 FLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLH 4602
Query: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK--DQLIQEAAAENNKLKEEIRG 2514
+L+ F++ + + D G+ ++ E R + + L + KL++ ++
Sbjct: 4603 EELE-FIRILGA---DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQA 4658
Query: 2515 LRSHMDDLNSENAKLDAELIQ------YREDLNQVITIKD--SQQKQLLEVQLQQNKELE 2566
+ D L + LD +I+ DLN T+KD ++ K+ QQ E+E
Sbjct: 4659 AVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN---TVKDQLNEMKEFKVEVYQQQIEME 4715
Query: 2567 --NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEI----ESLKVSISQLTRQVTA 2620
N +L K E + +R L+ ++L ++I L+ ++ L + A
Sbjct: 4716 KLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHA 4775
Query: 2621 LQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE---AAKKVGEIE 2677
L+E + + +L + + S ++ E+E V K A + E
Sbjct: 4776 LEELMSWLTHTEELLDAQRPI--------SGDPKVIEVELAKHHVLKNDVLAHQATVETV 4827
Query: 2678 DKLKKEL--KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
+K EL DA +R+ E + + + E EQ+L ++ +G ++I+
Sbjct: 4828 NKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIED 4887
Query: 2736 F----GRSMSSLQNSR------DHANEELDELKRKYDASLKELAQLKEQGLLNRERDALL 2785
F R S L S+ + A E+LD Y + LK + Q LL++ R LL
Sbjct: 4888 FLLELTRMESQLSASKPTGGLPETAREQLDTHMELY-SQLKAKEETYNQ-LLDKGRLMLL 4945
Query: 2786 SETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNER 2845
S S E S++ LE+ + SK E+ S+LE++ N F ++ N
Sbjct: 4946 SRDDSGSGSKTEQSVALLEQKWHVVSSKMEE---RKSKLEEALNLATEFQNSLQEFIN-- 5000
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPS----TSPAEVQSLKKAMSSLQNDRDRLLK-ELKNL 2900
W L E A+ PS T ++++ K + + RD++++ +
Sbjct: 5001 ---WLTL------AEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGN 5051
Query: 2901 QQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSW- 2959
Q ++L Q++ + L +Q +K I + + + H+ + W
Sbjct: 5052 QLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWL 5111
Query: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR--QASPETSASP 3017
E E + + + IS+ ++ + +E + + QP+ R +A E + P
Sbjct: 5112 EDAESHLDSE--LEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLP 5169
Query: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLR 3077
+ SQ L +R + + + +++ ++++ Q ++ L L L
Sbjct: 5170 EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 5229
Query: 3078 ENQQHYGDL 3086
E+Q +GDL
Sbjct: 5230 EDQPVHGDL 5238
Score = 183 bits (464), Expect = 3e-45
Identities = 606/3196 (18%), Positives = 1246/3196 (38%), Gaps = 515/3196 (16%)
Query: 300 EAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL 359
E N + N E+E++ + K+E+ ++ K S L E E E G+ E+
Sbjct: 1336 EVARNNMGNDTNEEQEKA---VTKIEI-ISHMKQSTSCLDSE-----EIRENQGEVILEV 1386
Query: 360 ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQT 419
+ Y K +E Q LQ +A + + E+++++ +
Sbjct: 1387 QETYCETSGKLPSE---------------QVLQQPMNARVKSKREKREVIVEESIRTCKP 1431
Query: 420 IQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT---EENIASLQKR 476
E++L Q++ + + + Q E S + E ++T EE+ + + +
Sbjct: 1432 AFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQ 1491
Query: 477 VVELENEKGALLLSSIELEELKAEN----------EKLSSQITL---------------- 510
+ +++ L SS + E K N E LS +I
Sbjct: 1492 GISVKHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEG 1551
Query: 511 LEAQNRTGEAD-REVSEISIVDIANKRSSSAEESGQD--VLENTFSQKHKELSVLLLEMK 567
L Q G+A S+IS D + + ++ E + QD V T KH+ S + K
Sbjct: 1552 LHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEK 1611
Query: 568 EAQEEIAF-----LKLQ-LQGKRAEEADHEVLDQKEMKQMEGEG-------IAPIKMKVF 614
QE ++F LKL+ + R + + L+ + K + +G +K ++
Sbjct: 1612 SYQE-VSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIA 1670
Query: 615 LED-TGQDFPLMPNEE-SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSL 672
++ TG+ F M N + L A E T+ SR + + G ++
Sbjct: 1671 TQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNA 1730
Query: 673 SAVPDIGQCHQDELERLKSQILELEL-NFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKN 731
P + LE + + + L + + K ++ ++ L E E K N
Sbjct: 1731 IISPTV-------LETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGN 1783
Query: 732 ADNNSSAFTALS---------EERDQLLSQVKELSMVTELRAQVKQLEMNLAEAE----R 778
N F A E ++L+S + L + Q++ LE+NLAE + +
Sbjct: 1784 GGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQ 1843
Query: 779 QRRLDYESQTAHDNLLTEQIHSLS--IEAKSKDVK---IEVLQNELDDVQLQFSEQSTLI 833
+ L+ E + L+++++ ++ I ++ ++V ++ L+ + ++Q S S
Sbjct: 1844 AKVLERELKDL-TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTW 1902
Query: 834 RSLQSQLQNK-ESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETL 892
S QN E E + + + ++++L + K L + + DV++L
Sbjct: 1903 NSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS---NSEIDVDSL 1959
Query: 893 QQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED 952
+ QQ ++ M E+ QL+ F + Q + A++ +Q +
Sbjct: 1960 NLCL----QQYEDLKQPMAERKAQLDALAFDI---------QFFISEHAQDLSPQQNRQM 2006
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINR--KELLQRVS 1010
+ + L++++ ++ + LQ +++E + + Q ++ ++L V
Sbjct: 2007 LRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVG 2066
Query: 1011 RLEEELANLKDESKKE----IPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTI 1066
+ E LA + + ++ + ++++ ++++D +N+ S V ++IE ++++
Sbjct: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVV---KDIEGFMEENQ 2123
Query: 1067 SE-KEVELQHIRKDLEEKLAAEEQFQALVKQ-----------MNQTLQDKTNQIDLLQAE 1114
++ EL +R+ L + A+EQ++AL ++ + LQ +T + + E
Sbjct: 2124 TKLSPRELTALREKLHQ---AKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAK-E 2179
Query: 1115 ISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSS-EHWKPELEEKILA----- 1168
++EN+ I L+ T S G S + + +G+S E + + +
Sbjct: 2180 LAENKKKIDALLDWVT--SVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAP 2237
Query: 1169 --LEKEKEQLQKKLQEALTSRKAILKKAQ---------------EKERHLREELKQQKDD 1211
L+K+ E ++ + QE L+ ++ + Q E+++ L+++L + K+
Sbjct: 2238 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQ 2297
Query: 1212 YNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKAT 1271
Y+ Q + + K+ + + D+L++ +Q + + L ++++ E + K
Sbjct: 2298 YSTSLAQSEAELKQVQTLQDELQKF-LQDHKEFESWLERSEKE---------LENMHKGG 2347
Query: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSE 1331
T P +L S SED + +G I Q K ++ E E K S
Sbjct: 2348 SSPETLP----SLLKRQGSFSEDVISHKGDLRFVTISGQ-KVLDMENSFKEGKEPSEIGN 2402
Query: 1332 LTK-----KSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-- 1384
L K +E L + + G + L H+ + A+SLQ +++ + + L
Sbjct: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462
Query: 1385 -----------EHL---RELQPKLDELQKLISKKEE---DVSYLSGQLSEKEAALTKIQT 1427
E L ++LQ +L E Q + K ++ D+ + G+ + + +
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
Query: 1428 EIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
I+ ++L L ++ + I Q Q ++ + IGE +Q ++ K +
Sbjct: 2523 SILSH---FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE---VEQNLEGKQVS 2576
Query: 1488 ALISR--KEALKENKSLQEELSLARGTIER-------------------LTKSLADVE-- 1524
+L S +EAL N L+++++ + ++E L LA+V
Sbjct: 2577 SLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQR 2636
Query: 1525 -SQVSAQNKEKDTVL--------------GRLALLQEERDKLITEMDRSLLENQSLSSSC 1569
Q+ Q +EK++ L G+L E + +++ ++ +
Sbjct: 2637 FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI 2696
Query: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIA-ESTEWQEKHKELQKEYEILLQSYENVSNE 1628
+ L L +E E+ + L + L S A + + Q++ + L+K++ L ++ + +
Sbjct: 2697 QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKD 2756
Query: 1629 AERIQHVVEAVRQEKQELYGKLRSTEAN--KKETEKQLQEAEQEMEEMKEKMRKFAKSKQ 1686
A Q ++ R+ + L+ TE + ET +E E+++E +K + +A SK
Sbjct: 2757 ASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA-SKG 2815
Query: 1687 QKILELEEENDRLRAEVH--PAGDTAKECMETLLSSNASMK--------EELERVKMEYE 1736
+ E+ + L + A D+ + L S +S+ ++L ++ +
Sbjct: 2816 TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMS 2875
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
++ K++ L E +Q + +++E V K+AN + + S P +
Sbjct: 2876 DVNLKYEKLGGVLHERQESLQAILNRME-EVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934
Query: 1797 TEEQDSLSMSTRPTCSE------SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLK---E 1847
TE + + S + +E + K A + + + E N+ + ++L E
Sbjct: 2935 TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWE 2994
Query: 1848 RIAGLEEEKQKNKEFS-------QTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
R + +Q+ E S Q E++ L + G L L + +N QQ
Sbjct: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ 3054
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK- 1959
+Q L K E ++ + L E L G ++ +Q++ EL K
Sbjct: 3055 VQFML----KEFEARRQQHEQLNEAAQGILT------GPGDVSLSTSQVQKELQSINQKW 3104
Query: 1960 -NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ 2018
L ++ + Q + + T+ + E+ ++ EK++ + +S E +K++
Sbjct: 3105 VELTDKLNSRSSQIDQAIVKSTQYQ-ELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQL 3163
Query: 2019 QEVKQLQKDCIRYQEKISALERTVKAL------EFVQTESQKDLEITKENLA----QAVE 2068
+E +++ D + ++ + L ++++ E +K LE L A +
Sbjct: 3164 EETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAAD 3223
Query: 2069 HRKKAQAELAS----------FKVLLDDTQSEAAR---VLADNLKLKKELQSNKESVKSQ 2115
+ QA LAS + LDD QS+ A+ + A +L+ +LQ N+E KS
Sbjct: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKS- 3282
Query: 2116 MKQKDEDLERRLEQAEEKHL-----KEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170
+ Q E + + E L +EK+ +Q +L L+ L + + Q L
Sbjct: 3283 LNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCM 3342
Query: 2171 KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230
++ Q+ Q +++ V + MS L+ D V E+ K A+ ++ E+ R
Sbjct: 3343 QKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSK---AMLNEVEKRR--- 3396
Query: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELL 2290
L ++ ++ IN S + D I + KA Q V + LQ + L
Sbjct: 3397 --------SLLEILNSAADILINSSEADED-GIRDEKAGIN-QNMDAVTEELQAKTGSLE 3446
Query: 2291 SQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350
+ R S +N +E +++ K QL ++ ++L NLE + QQE
Sbjct: 3447 EMTQRLREFQESFKN----IEKKVEGAKHQL-EIFDALGSQACSNKNLEKLRAQQEV--- 3498
Query: 2351 NSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI 2410
+ LE + R T L E+ G + + + AE+ QQ E+
Sbjct: 3499 -----LQALEPQVDYLRNFTQGLVEDAP----------DGSDASQLLHQAEVAQQEFLEV 3543
Query: 2411 KELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQ 2470
K+ N V+ E + + + + + +E Q A LD + M ++
Sbjct: 3544 KQRVN-------SGCVMMENKLEGIGQFHCRV-------REMFSQLADLDDELDGMGAIG 3589
Query: 2471 NDRDRIVGDYQQLEERHLSI----ILEKDQLIQEAAAENNKLKEE-----IRGLRSHMDD 2521
D D + Q+E+ L + +L+ D I+ + AE + EE + GL+ ++
Sbjct: 3590 RDTDSL---QSQIEDVRLFLNKIHVLKLD--IEASEAECRHMLEEEGTLDLLGLKRELEA 3644
Query: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581
LN + KL T + +++ LE+ L + ++ K L + +EE
Sbjct: 3645 LNKQCGKL---------------TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEE 3689
Query: 2582 A-------NEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTAL-QEEGTLGLYHAQ 2633
A ++ L + K ++++ L++ + Q+ L Q G
Sbjct: 3690 AEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGK----DCD 3745
Query: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGI 2693
++ E ++ ++A +++ K++A+ +L +EA G+ +D L+ L L +
Sbjct: 3746 VQGLEHDMEEINARWNTLNKKVAQRIAQL----QEALLHCGKFQDALEPLLSWLADTEEL 3801
Query: 2694 MRNETETAEERVAELARDLVEMEQKLLM-VTKENKGLTAQIQSFGR--SMSSLQNSRDHA 2750
+ N+ + E A+ EQKLL + + K +Q+ G + S+ R+
Sbjct: 3802 IANQKPPSAEYKVVKAQ---IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKI 3858
Query: 2751 NEELDELKRKYDASLKELAQLKEQ---GLLNRERDALLSETAFSMNSTEENSLSHLEKLN 2807
+L+ L+ ++ L + A ++Q L+ ++ +E S E L++ E +
Sbjct: 3859 TGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG 3918
Query: 2808 QQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAA 2867
Q +Q++ + ED N +A+ K +
Sbjct: 3919 TQTAKIQQQIIRHKALEEDIENHATDVHQAV-----------------------KIGQSL 3955
Query: 2868 QPSTSPAEVQSLKKAMSSLQ----NDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQE 2923
TSPAE L + + SLQ +DR ++ L Q + + L E
Sbjct: 3956 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE 4015
Query: 2924 YQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH 2983
+DK + + ++ +Q+ L QH H + E+ + + DQ + +
Sbjct: 4016 VEDKLSS--VFVKDFKQDVLHRQHADH-------------LALNEEIVNRKKNVDQAIKN 4060
Query: 2984 LQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ 3043
Q L+++ K+ + + + + + + + L T+ + +E+
Sbjct: 4061 GQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEEL-- 4118
Query: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDL----LNHCAVLEKQVQE 3099
+ + + +EE+ S T + + + QQ +L + H VL+ V E
Sbjct: 4119 ---------TGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNE 4168
Query: 3100 LQAGPLNIDVAPGAPQEKNGVHR-KSDPEE-------------------LREPQQSFSEA 3139
+ L ++ P +E G+ + SD E ++ QQ A
Sbjct: 4169 VSRALL--ELVPWRARE--GLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAA 4224
Query: 3140 QQQLCNTRQEVNELRKL--LEEERDQRVAAENALSVAEEQIRRLEHS--EWDSSRTPIIG 3195
+L + +L L + E+DQ A I R + S E S R+ I G
Sbjct: 4225 DAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG 4284
Query: 3196 SCGTQEQALLIDLTSN 3211
+CG +++ +L + T +
Sbjct: 4285 TCGEEQKTVLQEKTES 4300
Score = 182 bits (462), Expect = 5e-45
Identities = 631/3421 (18%), Positives = 1349/3421 (39%), Gaps = 455/3421 (13%)
Query: 35 HQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ-EERKAADNKI 93
+Q ++M N + ERL E + K +R D + +K + +E D +
Sbjct: 1238 NQTAEMSCNKVEES---ERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRK 1294
Query: 94 KKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
++ AK ++ +N + + K+ G L T P SE + + + + + K
Sbjct: 1295 PRMSSDAKEFISIINPHNLKGKSLGQVSL-THPYSECDFKLKEVARNNMGNDTNEEQEKA 1353
Query: 154 QEKEELISTLQAQLTQAQAEQPAQSSTEM-----EEFVMMKQQLQEKEEFISTLQAQLSQ 208
K E+IS ++ + +E+ ++ E+ E + +L ++ + A++
Sbjct: 1354 VTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARV-- 1411
Query: 209 TQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESL 268
++++ ++V+ E+ R L E++L Q + + E ++ R++ E+
Sbjct: 1412 -KSKREKREVIVEESIRTCKPAFLSEEKLYQ---ETAIRDEHDSHIKSQPREMTSSEKGK 1467
Query: 269 VGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEV 328
++ + ++ E +Q++ Q + + TL ++ + + L + L+
Sbjct: 1468 EADTEMGFSITFKIE--ESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKP 1525
Query: 329 AE---RKLSFHNLQEEMHHL------LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS 379
E R+++ E + L E G+AQ S+ S ++ + ++T+
Sbjct: 1526 EENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETN 1585
Query: 380 HILS-LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFL 438
+ S + +E + + + K Q+ + + + + + K +F
Sbjct: 1586 YQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFS 1645
Query: 439 NRLPLQQHETASQTSFPDVYNE--GTQAVTEE--------NIASLQKRVVE-LENEKGAL 487
+R L + S TQ +T E N+A L+ +E + ++G+
Sbjct: 1646 DRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSR 1705
Query: 488 LLSSIELEEL---KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA---E 541
+L S E+L ++ E Q ++ ++ VS + +++ E
Sbjct: 1706 VLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRE 1765
Query: 542 ESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQM 601
G + + + K + E A + + +L L+ + +L EM+
Sbjct: 1766 SPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTK 1825
Query: 602 EGEGIAPIKMKVF-LEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE 660
+ I P+++ + L+D ++ E L + ++ +Q S+ +
Sbjct: 1826 Q---IQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEV--PAQL 1880
Query: 661 LKSTKQDG---DKSLSAVPDIGQCH----QDELERLKSQILELELNFHKAQE-----IYE 708
LK+ ++D KSLS+V D Q+ +E K+++L + +
Sbjct: 1881 LKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGN 1940
Query: 709 KNLDEKAK------EISNLN---QLIEEFKKNADNNSSAFTALS---------------- 743
KNL +K ++ +LN Q E+ K+ + AL+
Sbjct: 1941 KNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSP 2000
Query: 744 EERDQLLSQVKELS-----MVTELRAQVKQLEMNLAEAERQ---RRLDYESQTAHDNL-- 793
++ Q+L + EL ++ + AQV L+ +L + E++ + L + T H L
Sbjct: 2001 QQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLED 2060
Query: 794 -----------------LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
T Q +++ D+K + DD+Q + + +T+++ +
Sbjct: 2061 LCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLK-----DLQDDIQNRATSFATVVKDI 2115
Query: 837 QSQLQNKES-----------EVLEGA--------ERVRHISSKVEELSQALSQKELEITK 877
+ ++ ++ E L A E R ++EE + Q+E E +K
Sbjct: 2116 EGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSK 2175
Query: 878 MDQLLLEKKRDVETLQQTI----EEKDQQVTEI--------------SFSMTEKMVQLNE 919
+ L E K+ ++ L + Q +T + + T+ + +N+
Sbjct: 2176 AAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQ 2235
Query: 920 --EKFSLGVEI------KTLKEQLNLLSRAEEAKKEQVEEDN----EVSSGLKQNYDEMS 967
EK E+ + L +Q N + + A+ + + E L+Q E+
Sbjct: 2236 APEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK 2295
Query: 968 PAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK--DESKK 1025
Q S Q E +L K+ + + +LQ L + KE + R E+EL N+ S +
Sbjct: 2296 E--QYSTSLAQSEAEL--KQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPE 2351
Query: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISE--KEVELQHIRKD---- 1079
+P +G ED + + + VT Q++ + ++ + E + E+ ++ KD
Sbjct: 2352 TLPSLLKRQGSFSEDVISHKGDLRFVTISGQKV-LDMENSFKEGKEPSEIGNLVKDKLKD 2410
Query: 1080 -LEEKLAAEEQFQALVKQMNQTL---QDKTNQIDLLQAEISENQAIIQKLITSNTDASDG 1135
E A + L +N L N D LQA + +A ++KL+ S+T ASD
Sbjct: 2411 ATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLL-SDTVASDP 2469
Query: 1136 DSVALVKETVVISPPCTGSSEHWKP-----ELEEKILALEKEKEQLQKKLQE-------- 1182
L ++ +EH P ++ I+ +E E + +QE
Sbjct: 2470 G--VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH 2527
Query: 1183 ------ALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQL 1236
+L R ++L+KA + + ++E L+ +++ + + + + G +
Sbjct: 2528 FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSG----VI 2583
Query: 1237 QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
Q + ++ K Q+ S +T + F T T VL+ L S +
Sbjct: 2584 QEALATNMKLKQDIARQKSSLEATREM-VTRFMETADSTTAAVLQGKLAE--VSQRFEQL 2640
Query: 1297 ALQGGTSVAQIKAQLKEIEA-EKVELELK-----VSSTTSELTKKSEEVFQLQEQINKQG 1350
LQ + +K L + E E + +L+ S + + +++ +QI +
Sbjct: 2641 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN 2700
Query: 1351 LEI----ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEE 1406
LE+ E+L T+ H S L+ Q Q + ++ L+ ELQK + ++E+
Sbjct: 2701 LEMEDQQENLDTLEH-LVTELSSCGFALDLCQHQ----DRVQNLRKDFTELQKTVKEREK 2755
Query: 1407 DVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQ 1466
D S QL E + Q + E E I T+ M AKE +++I+ L+ L +
Sbjct: 2756 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPP--TETSMSAKELEKQIEHLKSLLDDWAS 2813
Query: 1467 KPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE--RLTKSLADVE 1524
K + E + ++ + I+ ++ + S+ + + G++ K L +++
Sbjct: 2814 KGTLVEEINCKGTSLENLIME--ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2871
Query: 1525 SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL----T 1580
+S N + + + G L QE ++ M+ E S+ ES + L+ + +
Sbjct: 2872 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2931
Query: 1581 EDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVR 1640
K + VK + +AE + K +++++ LL +Y N S EAE + + E +
Sbjct: 2932 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN-SQEAENWKKIQEELN 2990
Query: 1641 QEKQELYGKLRSTEANKKETEKQLQEAEQEM---EEMKEKMRKFAKSKQQK---ILELEE 1694
+ R+TE ++QL+E+ + + + ++R + K+ + L
Sbjct: 2991 SRWE------RATEVTVAR-QRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
Query: 1695 ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE 1754
+ + L A+ K+ ++ +L +E E + ++E L++ Q +++ +S
Sbjct: 3044 DPNMLNAQ--------KQQVQFML-------KEFEARRQQHEQLNEAAQGILTGPGDVSL 3088
Query: 1755 EVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE- 1813
++ +++ Q +E T+K +++++ ++ E LS R
Sbjct: 3089 STSQVQKELQS--INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL 3146
Query: 1814 SVPSAKSANP-AVSKDFSSHDEINNYLQQID-QLKERIAGLEEEKQKNKEFSQTLENEKN 1871
SV SA S P AV + EI + L+Q+D ++KE +QTL +E +
Sbjct: 3147 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKE---------------AQTLCDELS 3191
Query: 1872 TLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLA 1931
L+ + KD K L+ + L + ++R+ + + Q
Sbjct: 3192 VLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ------------QFQ 3239
Query: 1932 ELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE---SEIRK 1988
++ + + D Q KN + ++++ L+ + E EE ++ L + E +E
Sbjct: 3240 QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGES 3299
Query: 1989 EYLEKIQGAQKEPGN------KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTV 2042
L G +K K+H +EL + ++Q +K + +YQ + L +
Sbjct: 3300 LLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWI 3359
Query: 2043 KALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLK 2102
+ + +E + L+ + L ++ K E+ + LL+ S A ++ + +
Sbjct: 3360 EDCKAKMSELRVTLDPVQ--LESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE 3417
Query: 2103 KELQSNKESVKSQMKQKDEDLERRLEQAEE--KHLKE----KKNMQEKLDALRREKVHLE 2156
++ K + M E+L+ + EE + L+E KN+++K++ + + + +
Sbjct: 3418 DGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIF 3476
Query: 2157 ETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFS 2216
+ +G Q NK ++++ QE L + Q+ L +D D ++ + +
Sbjct: 3477 DALGS-QACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQ--A 3533
Query: 2217 DAIQSKEEEIRLK-EDNCSVLKDQLR---QMSIHMEELKINISRLEHDKQIWESKAQTEV 2272
+ Q + E++ + C +++++L Q + E+ ++ L+ + + +
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD 3593
Query: 2273 QLQQKVCDTLQGENKELLSQLE------ETRHLYHSSQN-ELAKLESELKSLKDQLTDLS 2325
LQ ++ D NK + +L+ E RH+ +L L+ EL++L Q L+
Sbjct: 3594 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLT 3653
Query: 2326 NSLEKCKEQ----KGNLEGIIRQQEA--DIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
+ +EQ G +E R+ + D + E L+ + E+ ++ + M
Sbjct: 3654 ERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKM 3713
Query: 2380 KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439
+++ + L K + + L Q K+ +++ L EE N NKK +
Sbjct: 3714 FQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC-DVQGLEHDMEEINARWNTLNKKVAQRIA 3772
Query: 2440 QLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2499
QL E L K ++ + S D + ++ + + + ++++
Sbjct: 3773 QLQEALLHCGK--------FQDALEPLLSWLADTEELIANQKPPSAEY--------KVVK 3816
Query: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKL--DAELIQYREDLNQVITIKDSQQKQLLEV 2557
E L+ + ++ +D L +E ++ AEL RE + + +S+ +LL
Sbjct: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELAD-REKITGQLESLESRWTELLSK 3875
Query: 2558 QLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQ 2617
+ K+LE+ L ++ E+ E D F ++ E+K S+ + + I Q +
Sbjct: 3876 AAARQKQLED-ILVLAKQFHETAEPISD----FLSVTEKKLANSEPVGTQTAKIQQQIIR 3930
Query: 2618 VTALQE--EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGE 2675
AL+E E H +K+ + LS+L S +++ + L E++ +Q + E
Sbjct: 3931 HKALEEDIENHATDVHQAVKIGQS----LSSLTSPAEQGV--LSEKIDSLQ----ARYSE 3980
Query: 2676 IEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
I+D+ ++ L + N E+ V E+ L E+E KL V ++
Sbjct: 3981 IQDRCCRKAALLDQ---ALSNARLFGEDEV-EVLNWLAEVEDKLSSVF---------VKD 4027
Query: 2736 FGRSMSSLQNSRDH--ANEELDELKRKYDASLKE-LAQLK----EQGLLNRERDALLSET 2788
F + + Q++ DH NEE+ K+ D ++K A LK E+ LL +E+ +
Sbjct: 4028 FKQDVLHRQHA-DHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTR 4086
Query: 2789 AFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAM---ASLQNER 2845
+ T +L LE+ Q L+++ + +Y ++ + + + + +
Sbjct: 4087 YADITVTSSKALRTLEQARQ-----------LATKFQSTYEELTGWLREVEEELATSGGQ 4135
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSL--QNDRDRLLKELKNLQQQ 2903
++ +F++ ++ ++ + V + +A+ L R+ L K + + +Q
Sbjct: 4136 SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQ 4195
Query: 2904 YL----QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSW 2959
Y I Q + E+ + Q+Y+ A E +++ ++ L +R+E+
Sbjct: 4196 YKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMA----LGPIRLEQDQT 4251
Query: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDG 3019
+ K + I KD + L + E+ + + Q +Q +
Sbjct: 4252 TAQLQVQKAFSIDIIRHKD-SMDELFSHRSEIFGTCGEEQKTVLQ-------------EK 4297
Query: 3020 SQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQL---LEEKNTLSIQLCDTS--- 3073
+++L+ + E + ++ + + ++ + Q + +L +EE L QL +
Sbjct: 4298 TESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDH 4357
Query: 3074 QSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQ 3133
+ LR+ Q+ L A + + +L L I PQ K + +PEE +
Sbjct: 4358 EQLRQQQEEMRQLRESIAEHKPHIDKL----LKI-----GPQLK-----ELNPEEGEMVE 4403
Query: 3134 QSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPI 3193
+ + +A+ ++EV + L+E Q E + LE+ P+
Sbjct: 4404 EKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPL 4463
Query: 3194 I 3194
I
Sbjct: 4464 I 4464
Score = 97.8 bits (242), Expect = 2e-19
Identities = 340/1795 (18%), Positives = 720/1795 (40%), Gaps = 278/1795 (15%)
Query: 44 NTTQEDVQERLAYAEQLVV---ELKDIIRQKDVQLQQKDEALQEERK-AADNKIKKLKLH 99
NT + V +R+A ++ ++ + +D + L +E + ++ +A+ K+ K ++
Sbjct: 3761 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
Query: 100 AKAKLTSL----NKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE 155
+ L L ++ ++A+GG + + + E + EKI +L+
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRI----------------AQSAELADREKITGQLES 3864
Query: 156 KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA 215
E + L L++A A Q ++E+ +++ +Q E E IS LS T+ + A
Sbjct: 3865 LESRWTEL---LSKAAARQK-----QLEDILVLAKQFHETAEPISDF---LSVTEKKLAN 3913
Query: 216 QQVVREKDARFETQVRLH---EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRA 272
+ V + A+ + Q+ H E+++ T ++ Q L L E+ S
Sbjct: 3914 SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS----- 3968
Query: 273 QVVDLLQQELTAAEQR--------NQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM 324
+ +D LQ + + R +Q LS E E L E E + S + ++
Sbjct: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
Query: 325 ELEVAERKLSFH-NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383
+ +V R+ + H L EE+ + +K + K L
Sbjct: 4029 KQDVLHRQHADHLALNEEI-----------------------VNRKKNVDQAIKNGQALL 4065
Query: 384 LQKTGQE---LQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440
Q TG+E +Q D +K + + + ++ A+++ + +QL + Q +E++ +L
Sbjct: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSK-ALRTLEQARQLATKFQSTYEELTGWLRE 4124
Query: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE--KGALLLSSI-ELEEL 497
+ + E A+ G Q+ T E I Q+R EL+ E + L+L ++ E+
Sbjct: 4125 V---EEELATS---------GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRA 4172
Query: 498 KAENEKLSSQITLLEAQNRTGEADREVSE-----ISIVDIANKRSSSAEESGQDVLENTF 552
E ++ L + + E + VS+ + +D A +RS E++ L
Sbjct: 4173 LLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVA 4232
Query: 553 SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEAD----HEVLDQKEMKQMEGEGIAP 608
K K +++ + +++ Q QLQ ++A D + +D+ + E G
Sbjct: 4233 ETKRKLMALGPIRLEQDQTTA-----QLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCG 4287
Query: 609 IKMKVFLEDTGQDFPLMPNEESSL------PAVEKEQASTEHQSRTSEEISLNDAGVELK 662
+ K L++ + + E SL +E+ Q T EE+S ++
Sbjct: 4288 EEQKTVLQEKTESL-IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS-----PWIE 4341
Query: 663 STKQDGDKSLSAVPDIGQCHQ--DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN 720
T+ + S D Q Q +E+ +L+ I E + + K +I + + +E
Sbjct: 4342 ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE--- 4398
Query: 721 LNQLIEEFKKNADNNSSAFTALSEERDQLLSQ-VKELSMVTELRAQVKQLEMNLAEAERQ 779
+++EE + A+N + +R L + V + + +TE +++ + L +
Sbjct: 4399 -GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSR 4457
Query: 780 RRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQ 839
R+ D +I + KS V++E LQ + ++ + E LI +SQ
Sbjct: 4458 LRMPPLIPAEVD-----KIRECISDNKSATVELEKLQPSFEALKRRGEE---LIG--RSQ 4507
Query: 840 LQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEK 899
+K+ E +++ + E++ ++E++ + +L + D+ L TI++
Sbjct: 4508 GADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDT 4567
Query: 900 DQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL 959
V ++ S G++ +K+Q+ A E KE+ + +E +
Sbjct: 4568 QDIVHDLE---------------SPGIDPSIIKQQVE----AAETIKEETDGLHEELEFI 4608
Query: 960 K-QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELAN 1018
+ D + G+ K E++ D + E + + L ++ +Q + ++ L
Sbjct: 4609 RILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQA 4668
Query: 1019 LKDESKKEI-------PLS---ETERGEVEEDKENKE--YSEKCVTSKCQ-EIEIYLKQT 1065
+ D + P+ T + ++ E KE K Y ++ K + E+ LK+
Sbjct: 4669 MFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA 4728
Query: 1066 ISEKE--------VELQHIRKDLEEKLAAEE-----------QFQALVKQMNQTLQDKTN 1106
E + EL+H+ ++L EK+A + QFQ ++++ L
Sbjct: 4729 TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE 4788
Query: 1107 QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKI 1166
+D Q IS + +I+ + + ++K V+ + EL E
Sbjct: 4789 LLDA-QRPISGDPKVIEVELAKHH---------VLKNDVLAHQATVETVNKAGNELLES- 4837
Query: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKEN 1226
+ + L+ +L+ +++L+K +E+E+ L+ L+Q + ++ +++ E
Sbjct: 4838 -SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE----- 4891
Query: 1227 ENIGDQLRQLQIQVRESID-GKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLC 1285
L +++ Q+ S G LP T +++ + + KA E+ + Q + + L
Sbjct: 4892 ------LTRMESQLSASKPTGGLPETAREQLDTHMELYSQ--LKAKEETYNQLLDKGRLM 4943
Query: 1286 PDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ 1345
S + S + SVA ++ + + ++ E + K+ + T+ LQE
Sbjct: 4944 --LLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNS---LQEF 4998
Query: 1346 INKQGLEIESLKTVSHEAEVHAESLQQ----KLESSQLQIAGLEHLRELQPKLDELQKLI 1401
IN L +SL S + + L Q K+ ++++ A + + EL ++L K +
Sbjct: 4999 INWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVN-AHRDQIIELDQTGNQL-KFL 5056
Query: 1402 SKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI-------KALHTQLEMQAKEHDERI 1454
S+K+ DV + L ++ K+ IE+ + K H + ++
Sbjct: 5057 SQKQ-DVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAE 5115
Query: 1455 KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
L EL E+ P++I + ++ Q+ L ++ ++L+E+ L + +
Sbjct: 5116 SHLDSEL-EISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-Q 5173
Query: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
+L L +V + DTV G+ Q + ++ + L Q +
Sbjct: 5174 KLDNFLGEVRDKW-------DTVCGKSVERQHKLEEAL------LFSGQFMD-------- 5212
Query: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH 1634
AL+ L + K+ ++ E Q H +L L+ +++ E +
Sbjct: 5213 ALQALVDWLYKVEPQL-----------AEDQPVHGDLDLVMN-LMDAHKVFQKELGKRTG 5260
Query: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
V+ +++ +EL N ++ ++ QE+ + + K + SKQ ++ + +
Sbjct: 5261 TVQVLKRSGRELI-------ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 5313
Query: 1695 ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEK 1749
+ + R VH + E +TL A + ++ E ++ +T K+F + EK
Sbjct: 5314 QAEVFRDTVHMLLEWLSEAEQTLRFRGA-LPDDTEALQSLIDT-HKEFMKKVEEK 5366
Score = 94.4 bits (233), Expect = 2e-18
Identities = 425/2347 (18%), Positives = 904/2347 (38%), Gaps = 363/2347 (15%)
Query: 1036 EVEEDKENKEYSEK--CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093
E + +NKEY ++ C T K + K T+ ++ +++ +DL +
Sbjct: 481 EFQFSSQNKEYPDREDCTTEKGK------KTTVETEDSSVENPEQDLFVEQKERNPNIDA 534
Query: 1094 VKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTG 1153
+K +N+ + +Q ++ Q Q ++ +AS G + + PP
Sbjct: 535 LKVINKVKLE-------VQRQLIGTQREDQTAVSVRENASRGHLLTI--------PPA-- 577
Query: 1154 SSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213
+E +++ + ++E K++ Q + T Q + +
Sbjct: 578 EAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTC---------------------QNEQAH 616
Query: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQ 1273
L+ ++ +I Q ++LQ+QV++++ KL E S T G PL K
Sbjct: 617 TLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKL------ELKSETDGNVHPLDK---- 666
Query: 1274 HHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE-----KVELELKVSST 1328
+ + ++ L D S++A + GG+ + K ++ E LEL +T
Sbjct: 667 --KEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEAT 724
Query: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLK---TVSHEAEVHAESL---QQKLESSQLQIA 1382
+ L+ + + EQ ++ L E++ SH A E L Q +S +
Sbjct: 725 LNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESL 784
Query: 1383 GLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI----IEQEDLIKA 1438
E + + +DE KL+ +SG L + L ++ + +++E +
Sbjct: 785 TTEEVIN-EGLMDE--KLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRI 841
Query: 1439 LHTQLEMQAKEHDERIKQLQVELC------EMKQKPEEIGEESRAK-QQIQRKLQAALIS 1491
L Q+ +R K++ V L ++ +PE I E +K + ++ ++ LIS
Sbjct: 842 LERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLIS 901
Query: 1492 RKEAL------KENKSLQEELSLARGTIER------LTKSLAD--VESQVSAQNKEKDTV 1537
+ L S+ RG +ER LTK + D + +S D
Sbjct: 902 LQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNA 961
Query: 1538 LGRLALLQE---ERDKLITEMDRSLLENQSLSSSCESLK-LALEGLTEDKEKLVKEIESL 1593
R L+ E E+ K + ++ + N + K + L+ +T D ++ ++E+++
Sbjct: 962 F-RHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAF 1020
Query: 1594 KSSKI----AESTEWQEKHKELQKEYEILL---QSYENVSNEAERIQHVVEAVRQEKQEL 1646
+ + + E KE E +L + V E RI E V++ K ++
Sbjct: 1021 TGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI 1080
Query: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
R E K + + +K+ +++ Q ++ L A+ +
Sbjct: 1081 ESGQRYLEVIPFSDIK---------DGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTG 1131
Query: 1707 G--DTAKECMETLLSS--NASMKEELERVKMEYETLSKKFQSLMS-EKDSLSEEVQDLKH 1761
G DTA TL S+ + E + R+ ++ L+ + S ++ +L E ++ K
Sbjct: 1132 GIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIE--KR 1189
Query: 1762 QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
I ++ ++++E D++ + E + I + + L C+++ + +
Sbjct: 1190 LISPELANMIQIDSSEFSDHRAQI--EKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNK 1247
Query: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881
+ F ++ N Q +++K R++ E+ K K++E S L + KD
Sbjct: 1248 VEESERLF----QVENQSAQ-EKVKVRVSDGEQAK-KSREIS----------LKEFGCKD 1291
Query: 1882 GELKMLQEEVTK-MNLLN-QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN 1939
+ + + ++++N ++ + L E L+E N ++GN
Sbjct: 1292 QRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARN-------NMGN 1344
Query: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
+ + + + S MK C+ + +++ + + +V E+++ Y E + K
Sbjct: 1345 DTNEEQEKAVTKIEIISHMKQSTSCL-----DSEEIRENQGEVILEVQETYCET---SGK 1396
Query: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059
P + + + +K K+++ + + ++ IR + E + ++ E ++
Sbjct: 1397 LPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQ 1456
Query: 2060 KENLAQAVEHRKKAQAELA---SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
+ + E K+A E+ +FK+ + +++V+ + +K S K
Sbjct: 1457 PREMTSS-EKGKEADTEMGFSITFKI-----EESSSQVVPQGISVKHLDALTLFSSKQAN 1510
Query: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDAL-----RREKVHLEETIGEIQVT----LN 2167
+ K +L L E++L + + + R E +H +E+ G+ QVT ++
Sbjct: 1511 EGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQIS 1570
Query: 2168 KKDKEVQ----QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE 2223
K DK Q Q DS VT TK S ++ E E F A K
Sbjct: 1571 KTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNE----CKEKSYQEVSFDPARGLKL 1626
Query: 2224 EEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQ 2283
EEI + + ++ K + ++++ K+C TL+
Sbjct: 1627 EEITVSRP----------------DSKEVRYLEFSDRKDLHHQGSKSD----DKLCGTLK 1666
Query: 2284 GENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR 2343
E+ +Q + +A LE+ S++D +T + + + +G+ +
Sbjct: 1667 ---SEIATQELTGEKFLEMANPNVAGLEA--GSIEDIVTQRGSRVLGSFLPEKLFKGVSQ 1721
Query: 2344 QQEADIQNSKFSYEQLETDLQASRELT------------SRLHEEINMKEQKIISLLSGK 2391
++ QN+ S LET + + LT +L E ++ ++ GK
Sbjct: 1722 KENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGK 1781
Query: 2392 ----------EEAIQVAIAELRQQHD-----------------KEIKELENLLSQEEE-- 2422
V +L +HD K+I+ LE L++ ++
Sbjct: 1782 GNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLL 1841
Query: 2423 -ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481
+ VLE E K D T + + L+ + + I Q ++ + + + +L+ D +
Sbjct: 1842 CQAKVLERELK---DLTTLVSQELECVNQIIISQPQEVPA--QLLKALEKDAKNLQKSLS 1896
Query: 2482 QLEERHLSIILEKDQLIQ----EAAAENNKLKEEIRGLRSHMDDLN------SENAKLDA 2531
+ + S +L ++ + ++ +L+ ++ LR+ + + N N+++D
Sbjct: 1897 SVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDV 1956
Query: 2532 E----LIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR 2587
+ +Q EDL Q + + +Q L + ++ E S + N +
Sbjct: 1957 DSLNLCLQQYEDLKQPMAERKAQLDAL---------AFDIQFFISEHAQDLSPQQNRQML 2007
Query: 2588 RSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSAL 2647
R N LQ QD+ +E + L + +++E + Q +++ L +
Sbjct: 2008 RLLNELQRSFQDI---LEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSW 2064
Query: 2648 FSSSQKRIA-----ELEEELVCVQKEAAKKVGEIEDKLKKELKH----LHHDAGIM-RNE 2697
+++ +A +++L +QK + + +++D ++ + G M N+
Sbjct: 2065 VGQAERALAGHQGRTTQQDLSALQKNQS-DLKDLQDDIQNRATSFATVVKDIEGFMEENQ 2123
Query: 2698 TETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDEL 2757
T+ + + L L + +++ + +E + +++ S + + A +EL E
Sbjct: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
Query: 2758 KRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLE---KLNQQLLSKD 2814
K+K DA L + + G + L S S E+ +L + +NQ D
Sbjct: 2184 KKKIDALLDWVTSVGSSG--GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 2241
Query: 2815 EQLLHLSSQLEDSYNQVQSF----SKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870
+Q + ++ ++ +Q Q+F A A L +L E ++ + + G+ + Q S
Sbjct: 2242 KQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE--QYS 2299
Query: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH-------PLKAQLQE 2923
TS A+ ++ K + +LQ++ + L++ K + + +E+ +H L + L+
Sbjct: 2300 TSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKR 2359
Query: 2924 YQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHE---------RRMKEQYLMAI 2974
++ + +LR +S Q L K E E + E+Y
Sbjct: 2360 QGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALH 2419
Query: 2975 SDKDQQLSHLQNLIRELR-------SSSSQTQPLKVQYQRQASPETSASPDGSQNLVYET 3027
S + SHL L+ + S + Q + ++ S ++ P Q + T
Sbjct: 2420 SKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATT 2479
Query: 3028 ELLRTQLN------DSLKEIHQKELRIQ---------------QLNSNFSQL---LEEKN 3063
+ L+ +L + L+++ + + I+ + S+F L L E++
Sbjct: 2480 KQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERS 2539
Query: 3064 TLSIQLCDTSQSLRENQQHYGDLLNHCAVLE-----KQVQELQAGPLNIDVAPGAPQEKN 3118
+L + SQS++E+ + LL +E KQV L +G + +A +++
Sbjct: 2540 SLLQKAIAQSQSVQESLE---SLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
Query: 3119 GVHRKSDPEELREPQQSFSEAQQQLCNT--RQEVNELRKLLEEERDQRVAAENALSVAEE 3176
+KS E RE F E + ++ E+ + E+ Q+ E++L
Sbjct: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
Query: 3177 QIRRLEH 3183
Q EH
Sbjct: 2657 QAEMFEH 2663
Score = 81.3 bits (199), Expect = 1e-14
Identities = 300/1600 (18%), Positives = 632/1600 (39%), Gaps = 227/1600 (14%)
Query: 34 LHQESDMEFNNTTQEDVQERLAYAEQLVVELK-DIIRQKDVQLQQKDEALQEERKAADNK 92
L E ++E N E V+++L+ V + K D++ ++ +E + +K D
Sbjct: 4001 LFGEDEVEVLNWLAE-VEDKLSSV--FVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 4057
Query: 93 IKK----LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEK 148
IK LK ++ + + ++ +K + + T ++ L + + +T+ + E+
Sbjct: 4058 IKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 4117
Query: 149 IKHKLQEKEELISTLQAQL-TQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLS 207
+ L+E EE ++T Q T Q Q Q E+++ VM + + + +S +L
Sbjct: 4118 LTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELV 4177
Query: 208 QTQAEQAAQQVVREKDARFET---QVRLHEDEL-------LQLVTQADVE----TEMQQK 253
+A + ++V + + +++ + DE+ Q AD E E ++K
Sbjct: 4178 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRK 4237
Query: 254 LRVLQR-KLEEHEESL---VGRAQVVDLLQQ-----EL---------TAAEQRNQILSQQ 295
L L +LE+ + + V +A +D+++ EL T E++ +L ++
Sbjct: 4238 LMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEK 4297
Query: 296 LQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQ---EEMHHLLEQFEQA 352
+ + ++ + + + +ER LE+ ++ V + ++ L EE L+ Q
Sbjct: 4298 TESLIQQYEAI-SLLNSERYAR---LERAQVLVNQFWETYEELSPWIEETRALIAQLPSP 4353
Query: 353 GQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQ 412
+L + + Q ++ E K HI L K G +L+ L + +++++K ++
Sbjct: 4354 AIDHEQLRQQQEEMRQLRESIAEHKP-HIDKLLKIGPQLKE----LNPEEGEMVEEKYQK 4408
Query: 413 AVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIAS 472
A Q++++++Q++ + + ++ ++ T F D + T EN++S
Sbjct: 4409 A---ENMYAQIKEEVRQRALALDEAVS-------QSTQITEFHDKIEPMLE--TLENLSS 4456
Query: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
+ + E + + + E EKL EA R GE S+ + D+
Sbjct: 4457 RLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSF---EALKRRGEELIGRSQGADKDL 4513
Query: 533 ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEV 592
A K E+++ +++ F ++ RAEE + +
Sbjct: 4514 AAK-----------------------------EIQDKLDQMVFFWEDIKA-RAEEREIKF 4543
Query: 593 LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI 652
LD E+ + +A + + +DT QD P++ K+Q + E
Sbjct: 4544 LDVLELAEKFWYDMAALLTTI--KDT-QDIVHDLESPGIDPSIIKQQVEAAETIK-EETD 4599
Query: 653 SLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLD 712
L++ EL+ + G + A C + E ++ I E+ + A E K
Sbjct: 4600 GLHE---ELEFIRILGADLIFA------CGETEKPEVRKSIDEM----NNAWENLNKTWK 4646
Query: 713 EKAKEISNLNQLIEEFKKNA-------DNNSSAFTALSEERDQLLSQVKELSMVTELRAQ 765
E+ +++ + Q +++ DN + L + +L+ + E + +
Sbjct: 4647 ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVE 4706
Query: 766 VKQLEMNLAEAERQRRLDYESQTAHDN--LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ 823
V Q ++ + + Q L + T + ++ E + L ++ KI Q++L+
Sbjct: 4707 VYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGAL 4766
Query: 824 LQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883
L + + L S L + E E+L+ R IS + + E+E+ K L
Sbjct: 4767 LALGQFQHALEELMSWLTHTE-ELLDAQ---RPISGDPKVI-------EVELAKHHVL-- 4813
Query: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEE 943
K DV Q T+E ++ E+ S S G + +L+ +L +++ E
Sbjct: 4814 --KNDVLAHQATVETVNKAGNELLES-------------SAGDDASSLRSRLEAMNQCWE 4858
Query: 944 AKKEQVEE-DNEVSSGLKQNYDEMSPAGQISKEELQHEFDL-LKKENEQRKRKLQAALIN 1001
+ ++ EE + ++ S L+Q S E + E L K + L
Sbjct: 4859 SVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDT 4918
Query: 1002 RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEK---CVTSKCQEI 1058
EL ++ EE L D+ + + LS + G + +++ E+ V+SK +E
Sbjct: 4919 HMELYSQLKAKEETYNQLLDKGRLML-LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER 4977
Query: 1059 EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISEN 1118
+ L++ ++ E Q+ ++ L EQ + + L +QI+ + +E
Sbjct: 4978 KSKLEEALN-LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEV 5036
Query: 1119 QAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK 1178
A ++I + + ++ ++ V+I W+ ++ I + + +K
Sbjct: 5037 NAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI-ERGRSLDDARK 5095
Query: 1179 KLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238
+ ++ + K ++ ++ E HL EL+ D ++++ Q + + + +G +
Sbjct: 5096 RAKQFHEAWKKLIDWLEDAESHLDSELEISNDP-DKIKLQLSKHKEFQKTLGGKQPVYDT 5154
Query: 1239 QVRESIDGK----LPSTDQQ-----------------ESCSSTPGLEEPLFKATEQHHTQ 1277
+R K LP Q+ +S LEE L + +
Sbjct: 5155 TIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 5214
Query: 1278 PVL-------ESNLCPDWPSHSE--------DASAL-------QGGTSVAQIKAQLKEIE 1315
L E L D P H + DA + + GT V +K +E+
Sbjct: 5215 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGT-VQVLKRSGRELI 5273
Query: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
+ V EL+ + + V +L ++KQ ++LK +AEV +++ LE
Sbjct: 5274 ENSRDDTTWVKGQLQELSTRWDTVCKLS--VSKQSRLEQALK----QAEVFRDTVHMLLE 5327
Query: 1376 -----SSQLQIAGL--EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ-- 1426
L+ G + LQ +D ++ + K EE ++ ++ E L
Sbjct: 5328 WLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPD 5387
Query: 1427 --TEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEI-----GEESRAKQ 1479
T I +I+A ++ AK+H +R++ EL + EE+ E+ Q
Sbjct: 5388 CITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQ 5447
Query: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519
+ Q + + K + E+++ EE++ + ++R+TK+
Sbjct: 5448 RDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKT 5487
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 227 bits (578), Expect = 2e-58
Identities = 379/1783 (21%), Positives = 745/1783 (41%), Gaps = 278/1783 (15%)
Query: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSS--------GLKQNYDEMSPAGQISKEELQH 979
IK K+Q+ L+ +A+ E +E E+ S + + E A + K E +
Sbjct: 31 IKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQ 90
Query: 980 EFDLLKKENEQRKRKLQAALIN----RKELLQRVSRLEEELANLKDESKKEIPLSETERG 1035
+ LKKEN + K++++ ++ KEL Q +E+ NLK+E R
Sbjct: 91 QCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELM-------AVRS 143
Query: 1036 EVEEDKEN-KEYSEKCVTSKCQEIEIYLKQTISEKEV-----ELQHIRKDLEEK-LAAEE 1088
+ EDK N ++ E+ + ++ + E Q SE V E++ IR EE+ L ++
Sbjct: 144 KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK 203
Query: 1089 QFQALVKQMNQTLQDKTN-----------QIDLLQAEISENQAIIQ---KLITSNTDASD 1134
Q A + +T+ N I+ LQ E+ + +AI Q K + +AS
Sbjct: 204 QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263
Query: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA----------L 1184
+ A + + + E + +++K E E E L+K A L
Sbjct: 264 KEHEAEINKLNELKENLVKQCEASEKNIQKKY---ECELENLRKATSNANQDNQICSILL 320
Query: 1185 TSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSK---ENENIGDQLRQLQIQVR 1241
+ + EK +HL + LK+ + ++ L+++ + + E ++ R
Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHER 380
Query: 1242 ESIDGKLPS---TDQQESC------SSTPGLEEPLFKATEQH----------HTQPVLES 1282
E ++ K+ +++ C S GL + EQH H + + E
Sbjct: 381 EDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL 440
Query: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQ- 1341
N S E + + + +K Q + ++ EK E L S ++ E+ Q
Sbjct: 441 NETFLSDSEKEKLTLM---FEIQGLKEQCENLQQEKQEAILNYESL-----REIMEILQT 492
Query: 1342 -LQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI-AGLEHLRELQPKLDELQK 1399
L E K E ES+K ++VH LQQKL ++ + A LE + LQ E +K
Sbjct: 493 ELGESAGKISQEFESMKQ-QQASDVH--ELQQKLRTAFTEKDALLETVNRLQ---GENEK 546
Query: 1400 LISKKE--EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQL 1457
L+S++E ++ L EK + +++ ++K L ++ +E D+ I +L
Sbjct: 547 LLSQQELVPELENTIKNLQEKNGVYL---LSLSQRDTMLKELEGKINSLTEEKDDFINKL 603
Query: 1458 QVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517
+ EM ++ E R ++ +K++ + ++ N L+++++ G +E
Sbjct: 604 KNSHEEMDNFHKKCEREERLILELGKKVE-------QTIQYNSELEQKVNELTGGLEETL 656
Query: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE 1577
K E + Q EK ++ ++ +L E+++ L E+ EN LSS
Sbjct: 657 K-----EKDQNDQKLEK--LMVQMKVLSEDKEVLSAEVKSLYEENNKLSS---------- 699
Query: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSN--EAERIQHV 1635
+K++L +++E S K E +E +L+K+ +++++ +N++ E E++Q +
Sbjct: 700 ----EKKQLSRDLEVFLSQK--EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753
Query: 1636 VEAVRQEKQELYGKLR------STEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI 1689
K +LYG L+ S ++ +K+ LQ + + ++ E+ A + +K+
Sbjct: 754 FV-----KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKV 808
Query: 1690 LELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEK 1749
LELE+E L+ E + +C E +K L + E L K+ + + SEK
Sbjct: 809 LELEKEIKCLQEE------SVVQCEE--------LKSLLRDYEQEKVLLRKELEEIQSEK 854
Query: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT-NVTEEGTQSIPGETEEQDSLSMSTR 1808
++L ++ ++K+ E + NL + +QT + +E + +E ++L +
Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENL----K 910
Query: 1809 PTCSESVPSAKSANPAVSKD--FSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQ- 1864
P + + A + KD S N+ L + +L+E+I LE+E K+K ++ ++
Sbjct: 911 PLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKI 970
Query: 1865 -----TLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI---QEELSRVTKLKETAE 1916
+ E ++ + T EL+ L+ E +++ + + E + E
Sbjct: 971 KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQS 1030
Query: 1917 EEKDDLEERLMN---QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
E+ D +ER N ++ +L + N NE L + ++ L+ LE +
Sbjct: 1031 EQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQIL 1090
Query: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ- 2032
++ + K V+ E+ EK+Q QK + + EL+EL + Q+E KQLQK +
Sbjct: 1091 EVQRAKAMVDKELE---AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELEL 1147
Query: 2033 ------------EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+I+ ER +K L T +E ++ + + ++ Q E+ S
Sbjct: 1148 VKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSL 1207
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
+ + + + ++ +K KKEL +K++ + + L+ LE ++++ K
Sbjct: 1208 QSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ-ASLKGELEASQQQVEVYKIQ 1266
Query: 2141 MQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
+ E + HL+ + + Q TL+ + V LQE + + A T S +
Sbjct: 1267 LAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVR 1326
Query: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR-QMSIHMEELKINISRLE- 2258
V+ + K Q++ E + + ++ +L DQL+ ++ L+IN+S L+
Sbjct: 1327 VHNVLKQQKN-----KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQT 1381
Query: 2259 -----------HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNEL 2307
H+K + E+ ++ E +L++K+C ++Q EN + S+ +T +SQNE+
Sbjct: 1382 LQSEHDTLLERHNKMLQETVSK-EAELREKLC-SIQSENMMMKSEHTQTVSQL-TSQNEV 1438
Query: 2308 AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR 2367
+ S +DQ+ L K E ++QQ + ++ F + T +R
Sbjct: 1439 LR-----NSFRDQVRHLQEEHRKTVE-------TLQQQLSKMEAQLFQLKNEPT----TR 1482
Query: 2368 ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVL 2427
S N++E R+ D + ++ + +E E
Sbjct: 1483 SPVSSQQSLKNLRE---------------------RRNTDLPLLDMHTVTREEGEGMETT 1521
Query: 2428 EEENKKAVDKTNQLMETLKTIKKENIQ-----QKAQLDSFVKSMSSLQNDRDRIVGDYQQ 2482
+ E+ + Q +E L + ++ + + V+ +SS D + G
Sbjct: 1522 DTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNG---- 1577
Query: 2483 LEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDL--NSENAKLDAELIQYREDL 2540
L++E A N L E+I+ L+S + L N E K A L + L
Sbjct: 1578 --------------LLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVL 1623
Query: 2541 NQVITIKDSQQKQ----LLEVQLQQNKELENKYAKLEEKLKES 2579
Q I +K +++ ++ LQ + E + K A + + +E+
Sbjct: 1624 LQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEEN 1666
Score = 209 bits (532), Expect = 4e-53
Identities = 336/1573 (21%), Positives = 670/1573 (42%), Gaps = 232/1573 (14%)
Query: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL 1370
+KEIE K EL + V S SE K+ QL+E +N Q LE+ + +E + + L
Sbjct: 128 VKEIENLKNEL-MAVRSKYSE--DKANLQKQLEEAMNTQ-LELSEQLKFQNNSEDNVKKL 183
Query: 1371 QQKLESS----QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTK-- 1424
Q+++E + QI L+ ++L DE ++ +++ + + S + +L +
Sbjct: 184 QEEIEKIRPGFEEQILYLQ--KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEEL 241
Query: 1425 IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK 1484
+Q + I QE+ +K L Q+E AKEH+ I +L EL E K E E++ IQ+K
Sbjct: 242 LQLKAIHQEE-VKELMCQIEASAKEHEAEINKLN-ELKENLVKQCEASEKN-----IQKK 294
Query: 1485 LQAALISRKEALKENKS-------LQEELSLARGTIERLTKSLADVESQVSAQN---KEK 1534
+ L + ++A L +E + + K L D ++ +Q+ K++
Sbjct: 295 YECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDE 354
Query: 1535 DTVLGRLALLQE------------ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTED 1582
T + L L E ER+ L +++ LL + E LK L GL +
Sbjct: 355 VTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414
Query: 1583 ----KEKLVKEIESLKSSKIAESTEWQEKH-KELQKEYEILLQSYENVSNEAERIQHVVE 1637
E+ +E++SLK E +E E + +KE L+ + + + E +Q
Sbjct: 415 FCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ---- 470
Query: 1638 AVRQEKQEL---YGKLRST-EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693
QEKQE Y LR E + E + + QE E MK++ QQK+
Sbjct: 471 ---QEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAF 527
Query: 1694 EENDRLRAEVHPA-GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSL 1752
E D L V+ G+ K L S + ELE + + + +S++D++
Sbjct: 528 TEKDALLETVNRLQGENEK------LLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTM 581
Query: 1753 SEEVQDLKHQIEGNVSKQANLEATEKHD--NQTNVTEEGTQSIPGETEEQDSLSMSTRPT 1810
+E +EG + N EK D N+ + E + + E ++ L +
Sbjct: 582 LKE-------LEGKI----NSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK 630
Query: 1811 CSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG----LEEEKQKNKEFSQTL 1866
+++ V++ +E Q DQ E++ L E+K+ ++L
Sbjct: 631 VEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690
Query: 1867 ENEKNTLLSQISTKDGELKM---------LQEEVTKMNLLNQQIQEELSRVTKLKETAEE 1917
E N L S+ +L++ L+E +T++ Q + EE + KL E +
Sbjct: 691 YEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQV 750
Query: 1918 EKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK 1977
+K ++ +L L E+ + +D + + N L + + + ++++ EEK L
Sbjct: 751 QKLFVKTQLYGFLKEMGSEVS---EDSEEKDVVNVL-----QAVGESLAKINEEKCNLAF 802
Query: 1978 EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISA 2037
++ + E+ KE I+ Q+E + +EL+ LL++ +QE L+K+ Q + A
Sbjct: 803 QRDEKVLELEKE----IKCLQEE--SVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEA 856
Query: 2038 L-----------ERT--------VKALEFVQTESQKDLEITKE--------NLAQAVEHR 2070
L E+T ++ E QT S+ ++ KE NL +E +
Sbjct: 857 LQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK 916
Query: 2071 --KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER--- 2125
+ +AEL +LL D+ +++ V D L KEL+ E+++ + K+K+E + +
Sbjct: 917 ELRDRRAEL----ILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL 972
Query: 2126 ---RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEI-------QVTLNKKDKEVQQ 2175
+ ++ + KE + ++E+L++LR EK L ++ ++ + L + +K+ +Q
Sbjct: 973 VAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQ 1032
Query: 2176 L----------QENLDSTVTQLAAFTKSMSSLQDDRDRVI-------DEAKKWERKFSDA 2218
L + ++ QL T ++ D + ++ AK E + +
Sbjct: 1033 LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092
Query: 2219 IQSK------------EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWES 2266
++K ++E ++KE +V ++L ++ + +++ K + + + ++ +
Sbjct: 1093 QRAKAMVDKELEAEKLQKEQKIKEHATTV--NELEELQVQLQKEKKQLQKTMQELELVKK 1150
Query: 2267 KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSN 2326
AQ + ++ D + KEL +L + + E+ + + ++L++++T L +
Sbjct: 1151 DAQQTTLMNMEIAD-YERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQS 1209
Query: 2327 SLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD---LQAS----------------- 2366
S+++ +E+ ++ ++ + + ++ +SK Q ETD LQAS
Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSK----QAETDHLILQASLKGELEASQQQVEVYKI 1265
Query: 2367 --RELTS---RLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE 2421
E+TS ++HE + ++ LS ++ + E R ++ S +
Sbjct: 1266 QLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKV 1325
Query: 2422 EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481
+ VL+++ K++ + + K+E + +D + QN+ V + Q
Sbjct: 1326 RVHNVLKQQKNKSMSQAET-----EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ 1380
Query: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541
L+ H +++ ++++QE ++ +L+E++ ++S + SE+ + ++L E L
Sbjct: 1381 TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLR 1440
Query: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601
+ +D Q + L E + + L+ + +K+E +L + + NE RS Q
Sbjct: 1441 N--SFRD-QVRHLQEEHRKTVETLQQQLSKMEAQLFQLK--NEPTTRS----PVSSQQSL 1491
Query: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661
K + + + L T +EEG E V S S ++ + E +
Sbjct: 1492 KNLRERRNTDLPLLDMHTVTREEG-----EGMETTDTESVSSASTYTQSLEQLLNSPETK 1546
Query: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721
L A E+ KL K H G++R ETE + E + L++ E + L
Sbjct: 1547 LEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLR-ETEATNAILMEQIK-LLKSEIRRLE 1604
Query: 2722 VTKENKGLTAQIQ 2734
+E + A ++
Sbjct: 1605 RNQEREKSAANLE 1617
Score = 208 bits (530), Expect = 6e-53
Identities = 350/1656 (21%), Positives = 710/1656 (42%), Gaps = 233/1656 (14%)
Query: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDS-LSEEVQDLKHQIEGNVSKQAN 1772
ME L+ + K + ETL K+ ++K L ++ + ++E + + +
Sbjct: 1 MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS 60
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
TE + E ++ E E + +S + E++ + +V+K +H
Sbjct: 61 KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLK---KENIKMKQEVEDSVTKMGDAH 117
Query: 1833 DEIN----NYLQQIDQLKERIAGLEEEKQKNK-EFSQTLENEKNTLLSQISTKDGELKML 1887
E+ NY+++I+ LK + + + ++K + LE NT L L
Sbjct: 118 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLE-----------L 166
Query: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA 1947
E++ N V KL+E E+ + EE+++ +L+ + + VT
Sbjct: 167 SEQLKFQN-------NSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQL 219
Query: 1948 QIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Q ++E+ ++ +K ++ L+EE QL + E KE + +I+ + KE H
Sbjct: 220 Q---NIIEANSQHYQKNINSLQEELLQL----KAIHQEEVKELMCQIEASAKE-----HE 267
Query: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISA-LERTVKALEFVQTESQKDLEITKEN---- 2062
E+ +L + K+ VKQ + Q+K LE KA ++Q + +EN
Sbjct: 268 AEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVE 327
Query: 2063 --LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD 2120
+ + V+H + EL S +L D + +NLKLK E+ + + +K + +
Sbjct: 328 QVVNEKVKHLEDTLKELESQHSILKDEVT-----YMNNLKLKLEMDA--QHIKDEFFHER 380
Query: 2121 EDLERRLEQ---AEEKHLKEKKNMQEKLDALRREKVH-LEETIGEIQVTLNKKDKEVQQL 2176
EDLE ++ + A+E+ + ++ +L L ++ + +E+ E+Q + KE+ +L
Sbjct: 381 EDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL 440
Query: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
E T L+ K +L + + ++ + +++ +AI + E + E + L
Sbjct: 441 NE------TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
Query: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
+ ++S E +K + H+ Q A TE + + LQGEN++LLSQ E
Sbjct: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554
Query: 2297 RHLYHSSQN-----------------ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
L ++ +N L +LE ++ SL ++ D N L+ E+ N
Sbjct: 555 PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614
Query: 2340 GIIRQQEADIQNSKFSYEQL---ETDL-QASRELTSRLHEEINMKEQKI---------IS 2386
++E I EQ ++L Q ELT L E + K+Q +
Sbjct: 615 KKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMK 674
Query: 2387 LLSGKEEAIQVAIAELRQQHDKEIKE-------LENLLSQEEE----ENIV-LEEENKKA 2434
+LS +E + + L ++++K E LE LSQ+E+ E+I LE++ +
Sbjct: 675 VLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLM 734
Query: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSL---QNDRDRIVGDYQQLEERHLSII 2491
V++ + L + L+ + + + K QL F+K M S ++ +V Q + E I
Sbjct: 735 VEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794
Query: 2492 LEKDQLIQEAAAENNKLKEEIRGLRSHM----DDLNSENAKLDAELIQYREDLNQVITIK 2547
EK L + + +L++EI+ L+ ++L S + E + R++L ++ + K
Sbjct: 795 EEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854
Query: 2548 DSQQKQLLEVQLQQNK---ELENKYAKLEE---KLKESEEANEDLR------RSFNALQE 2595
++ Q LLE++ K E +N ++EE +SE NE + + L E
Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLE 914
Query: 2596 EKQDLSKEIE------SLKVSISQLTRQVTALQE-EGTLGLYHAQLKVKEEEVHRLSALF 2648
+K+ + E SL S S +++++E E + + K KEE+++++ +
Sbjct: 915 QKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVA 974
Query: 2649 SSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN------------ 2696
++K + +E V++E E +D+L ++ L A +N
Sbjct: 975 VKAKKELDSSRKETQTVKEELESLRSE-KDQLSASMRDLIQGAESYKNLLLEYEKQSEQL 1033
Query: 2697 --ETETA---EERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL-------Q 2744
E E A E R+ +L R L + + +N+ L A+I++ + L Q
Sbjct: 1034 DVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ 1093
Query: 2745 NSRDHANEELDELKRKYDASLKELA----QLKE-QGLLNRERDAL---LSETAFSMNSTE 2796
++ ++EL+ K + + +KE A +L+E Q L +E+ L + E +
Sbjct: 1094 RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQ 1153
Query: 2797 ENSLSHLEKLNQQLLSKD--EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEK 2854
+ +L ++E + + L K+ ++L + ++++ED +++ + +LQ E L + +++
Sbjct: 1154 QTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQ 1213
Query: 2855 FRKSEEGKQRSAAQPSTSPAEVQSLKK----AMSSLQNDRDRLLKELKNLQQQYLQINQE 2910
+ + ++ + A+ + + +SL+ + + ++++ + Q +I E
Sbjct: 1214 YEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSE 1273
Query: 2911 ITELHP-LKAQLQEYQDKTKAFQ----IMQEELR-----QENLSWQHELHQLRMEK---- 2956
++H LK +++Q A+Q +QEE R Q ++ + E +++R+
Sbjct: 1274 KHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ 1333
Query: 2957 ------SSWEIHERRMKEQYLMAISDK------DQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
S E + + ++L + D+ D Q ++LQ + EL++ S+ L +
Sbjct: 1334 QKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQ-NNLQINVSELQTLQSEHDTLLER 1392
Query: 3005 YQRQASPETSASPD--------GSQNLVYETE-------------LLRTQLNDS---LKE 3040
+ + S + S+N++ ++E +LR D L+E
Sbjct: 1393 HNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQE 1452
Query: 3041 IHQKELRI--QQLNSNFSQLLEEKNTLSIQLCDTSQ----SLRENQQHYGDLLNHCAVLE 3094
H+K + QQL+ +QL + KN + + +SQ +LRE + LL+ V
Sbjct: 1453 EHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTR 1512
Query: 3095 KQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREP-----QQSFSEAQQQLCNTRQE 3149
++ + ++ V+ + ++ + PE EP + + E Q+L +T +
Sbjct: 1513 EEGEGMETTDTE-SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKS 1571
Query: 3150 VNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185
+ L LL E + + + +IRRLE ++
Sbjct: 1572 ADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQ 1607
Score = 199 bits (505), Expect = 5e-50
Identities = 375/1780 (21%), Positives = 751/1780 (42%), Gaps = 281/1780 (15%)
Query: 350 EQAGQAQAELESRYSALEQKHKAE-----MEEKTSHILSLQKTGQELQSACDALKDQNSK 404
++A ELE L K E ++ T + +L E + C +LK +N K
Sbjct: 42 QKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIK 101
Query: 405 LLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464
+ Q+ + + ++LE KEI N L ++
Sbjct: 102 MKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNEL------------------MAVRS 143
Query: 465 VTEENIASLQKRVVELENEKGALLLSSIEL-EELKAENEKLSSQITLLE--AQNRTGEAD 521
E+ A+LQK++ E N + +EL E+LK +N + L E + R G +
Sbjct: 144 KYSEDKANLQKQLEEAMN-------TQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEE 196
Query: 522 REVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVL---LLEMKEA-QEEIAFLK 577
+ + +D Q+++E K ++ L LL++K QEE+ L
Sbjct: 197 QILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELM 256
Query: 578 LQLQGKRAEEADHEV-----LDQKEMKQME-GEGIAPIKMKVFLEDTGQDFPLMPNEESS 631
Q++ A+E + E+ L + +KQ E E K + LE+ + +S
Sbjct: 257 CQIEAS-AKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL--------RKATS 307
Query: 632 LPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKS 691
+ + S Q T E +N+ L+ T ++ + S + +DE+ + +
Sbjct: 308 NANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSIL-------KDEVTYMNN 360
Query: 692 QILELELN--------FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
L+LE++ FH+ +++ E ++E +IE+ K + F
Sbjct: 361 LKLKLEMDAQHIKDEFFHEREDL-EFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTV 419
Query: 744 EERDQLLSQVKELSMVTELRAQVKQL-EMNLAEAERQR-RLDYESQTAHDNLLTEQIHSL 801
E+ ++ + +KE + + ++ +L E L+++E+++ L +E Q L EQ +L
Sbjct: 420 EQHNREVQSLKE-----QHQKEISELNETFLSDSEKEKLTLMFEIQG-----LKEQCENL 469
Query: 802 SIEAKSKDVKIEVLQNELDDVQLQFSEQSTLI-RSLQSQLQNKESEVLEGAERVRHISSK 860
E + + E L+ ++ +Q + E + I + +S Q + S+V E +++R ++
Sbjct: 470 QQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTE 529
Query: 861 VEELSQALSQKELEITKM---DQLLLEKKRDVETLQQ-------TIEEKDQQVTEISFSM 910
+ L + +++ + E K+ +L+ E + ++ LQ+ ++ ++D + E+
Sbjct: 530 KDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE--- 586
Query: 911 TEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAKK------EQVEEDNEVSSGLKQNY 963
K+ L EEK ++K E++ N + E ++ ++VE+ + +S L+Q
Sbjct: 587 -GKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKV 645
Query: 964 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
+E++ + KE +Q +KL+ ++ K L + L E+ +L +E+
Sbjct: 646 NELTGG-----------LEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEEN 694
Query: 1024 KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS--EKEVELQHIRKDLE 1081
K E K+ S Q+ ++ LK+ I+ EK+++L +D
Sbjct: 695 NK-------------LSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNL 741
Query: 1082 EKLAAEEQFQALV--KQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVA 1139
KL EQ Q L Q+ L++ +++ +E SE + ++ N + G+S+A
Sbjct: 742 NKLLENEQVQKLFVKTQLYGFLKEMGSEV----SEDSEEKDVV------NVLQAVGESLA 791
Query: 1140 LVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKER 1199
+ E C + + +EK+L LEKE + LQ++ K++L+ ++++
Sbjct: 792 KINE-----EKCNLAFQR-----DEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKV 841
Query: 1200 HLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRE--SIDGKLPSTDQQESC 1257
LR+EL++ + + LQ E NE + + L IQV E K +++E C
Sbjct: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC 901
Query: 1258 ------SSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQL 1311
+ P LE+ K + +L + PS D +SV +++ ++
Sbjct: 902 FIKEHENLKPLLEQ---KELRDRRAELILLKDSLAKSPSVKNDPL-----SSVKELEEKI 953
Query: 1312 KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQ 1371
+ +E E E E K++ K +E+ +++ E+ESL++ + L
Sbjct: 954 ENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013
Query: 1372 QKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIE 1431
Q ES + + E E +LD ++ + E + L+ QL I + +
Sbjct: 1014 QGAESYKNLLLEYEKQSE---QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINS---D 1067
Query: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALIS 1491
EDL+ + T L+ A K L+V++ E++ RAK + ++L+A +
Sbjct: 1068 NEDLLARIET-LQSNA-------KLLEVQILEVQ----------RAKAMVDKELEAEKLQ 1109
Query: 1492 RKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE-KDTVLGRLALLQEERDK 1550
+++ +KE+ + EL + +++ K L ++ K+ + T L + + ER
Sbjct: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYER-- 1167
Query: 1551 LITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE 1610
L+ E+++ L ++ E L+ ++ + +E L +EI SL+SS +++EK+ +
Sbjct: 1168 LMKELNQKLTNK---NNKIEDLEQEIKIQKQKQETLQEEITSLQSS----VQQYEEKNTK 1220
Query: 1611 LQKEYEILLQSYENV--SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAE 1668
++ ++L+++ + + S +AE +++A L G+L +++ + + QL E
Sbjct: 1221 IK---QLLVKTKKELADSKQAETDHLILQA------SLKGELEASQQQVEVYKIQLAEIT 1271
Query: 1669 QEMEEMKEKMRKFAK-------SKQQKILELEEENDRLRAE---VHPAGDTAKECMETLL 1718
E ++ E ++ A+ + QQ++ L+EE +AE V ++ K + +L
Sbjct: 1272 SEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVL 1331
Query: 1719 --SSNASMKE-ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA 1775
N SM + E E K E E L D L ++QD ++ ++ NVS+ L++
Sbjct: 1332 KQQKNKSMSQAETEGAKQEREHLEMLI-------DQLKIKLQDSQNNLQINVSELQTLQS 1384
Query: 1776 TEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI 1835
+HD + E + + ++ L SE++ VS+ S ++ +
Sbjct: 1385 --EHD---TLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVL 1439
Query: 1836 NNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMN 1895
N ++++ L+EE +K E TL Q+S + +L L+ E T +
Sbjct: 1440 RN------SFRDQVRHLQEEHRKTVE----------TLQQQLSKMEAQLFQLKNEPTTRS 1483
Query: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE 1955
++ Q LK E DL M+ + G + TD +
Sbjct: 1484 PVSSQ--------QSLKNLRERRNTDLPLLDMHTVTREEGE----GMETTDTE------- 1524
Query: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
++ + + +Q L +TK+E + K + QK A L LL+
Sbjct: 1525 ----SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLR 1580
Query: 2016 EKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQ 2049
E + E +L K IR E+ E++ LE+++
Sbjct: 1581 ETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLK 1620
Score = 182 bits (463), Expect = 4e-45
Identities = 297/1397 (21%), Positives = 594/1397 (42%), Gaps = 196/1397 (14%)
Query: 1901 IQEELSRVTKLKETAEEEKDD------------LEERLMNQLAELNGSIGNYCQDVTDAQ 1948
IQ+ SR T+L++ EE + L ERL L E C +
Sbjct: 41 IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLE-KAETEQQCLSLKKEN 99
Query: 1949 IK-NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE---IRKEYLEKIQGAQKEPGNK 2004
IK + +E + + ELE+ VKE +++E +R +Y E QK+
Sbjct: 100 IKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEA 159
Query: 2005 SHAK-ELQELLK---EKQQEVKQLQKDCIR----YQEKISALERTVKALEFVQTESQKDL 2056
+ + EL E LK + VK+LQ++ + ++E+I L++ + A T+ +K+
Sbjct: 160 MNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDAT----TDEKKET 215
Query: 2057 EITKENLAQA-VEHRKK----AQAELASFKVLLDDTQSEAARVLADNLKLKK----ELQS 2107
+N+ +A +H +K Q EL K + + E + + K + +L
Sbjct: 216 VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNE 275
Query: 2108 NKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK---LDALRREKVHLEETIGEIQV 2164
KE++ Q + +++++++ E E K N + L +E +E+ + E
Sbjct: 276 LKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVK 335
Query: 2165 TLNKKDKEVQQLQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQSKE 2223
L KE++ L VT + + Q +D E + E K ++ + +KE
Sbjct: 336 HLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKE 395
Query: 2224 EE-----------IRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH----DKQIWESKA 2268
E+ L + C ++ R++ E+ + IS L D + +
Sbjct: 396 EQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTL 455
Query: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA----KLESELKSLKDQ-LTD 2323
E+Q ++ C+ LQ E +E + E R + Q EL K+ E +S+K Q +D
Sbjct: 456 MFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASD 515
Query: 2324 LSNSLEKCK----EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI-N 2378
+ +K + E+ LE + R Q +N K L + +EL L I N
Sbjct: 516 VHELQQKLRTAFTEKDALLETVNRLQG---ENEK---------LLSQQELVPELENTIKN 563
Query: 2379 MKEQKIISLLSGKE-----EAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK 2433
++E+ + LLS + + ++ I L ++ D I +L+N S EE +N +KK
Sbjct: 564 LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKN--SHEEMDNF-----HKK 616
Query: 2434 AVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493
+ ++E K ++ + IQ ++L+ V ++ G + L+E+ +
Sbjct: 617 CEREERLILELGKKVE-QTIQYNSELEQKVNELTG---------GLEETLKEKD-----Q 661
Query: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQ 2553
DQ +++ + L E+ L + + L EN KL +E Q DL ++ K+ +
Sbjct: 662 NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721
Query: 2554 LLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS--FNALQEEKQDLSKEIESLKVSI 2611
QL++ +L + KL E+E+ + ++ + L+E ++S++ E V
Sbjct: 722 EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV-- 779
Query: 2612 SQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAK 2671
V LQ G + K+ EE+ + L +++ ELE+E+ C+Q+E+
Sbjct: 780 ------VNVLQAVG-----ESLAKINEEKCN----LAFQRDEKVLELEKEIKCLQEESVV 824
Query: 2672 KVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTA 2731
+ E LK L+ + ++R E E + L DL+EM+ EN+ L
Sbjct: 825 QCEE----LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLI 880
Query: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
Q++ ++ S+ + E ++ K +LK L + KE L +R + +L + + +
Sbjct: 881 QVEEVSQTC-----SKSEIHNEKEKCFIKEHENLKPLLEQKE--LRDRRAELILLKDSLA 933
Query: 2792 MNSTEEN----SLSHLEK----LNQQLLSKDEQL-------LHLSSQLEDSYNQVQSFSK 2836
+ + +N S+ LE+ L ++ K+E++ + +L+ S + Q+ +
Sbjct: 934 KSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKE 993
Query: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKE 2896
+ SL++E+D L + + E + + ++ K+ ++ ++ + L ++
Sbjct: 994 ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQ 1053
Query: 2897 LKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEK 2956
L+N Q IN + + L A+++ Q K ++ E+++ EL +++K
Sbjct: 1054 LRNSTLQCETINSDNED---LLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK 1110
Query: 2957 SSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016
E+++KE + +++ ++ LQ ++L+ + + + +K Q+ +
Sbjct: 1111 ------EQKIKE-HATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIA 1163
Query: 3017 PDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQ------------LNSNFSQLLEEKNT 3064
+ L+ E T N+ ++++ Q E++IQ+ L S+ Q EEKNT
Sbjct: 1164 --DYERLMKELNQKLTNKNNKIEDLEQ-EIKIQKQKQETLQEEITSLQSSVQQ-YEEKNT 1219
Query: 3065 LSIQ-LCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDV----APGAPQEKNG 3119
Q L T + L +++Q D H + EL+A ++V EK+
Sbjct: 1220 KIKQLLVKTKKELADSKQAETD---HLILQASLKGELEASQQQVEVYKIQLAEITSEKHK 1276
Query: 3120 VHR--KSDPEELREPQQSFSEAQQQLCNTRQEVN----ELRKLLEEERDQRVAAENALSV 3173
+H K+ E + Q++ S QQ++ ++E E + E +V N L
Sbjct: 1277 IHEHLKTSAE---QHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLK- 1332
Query: 3174 AEEQIRRLEHSEWDSSR 3190
+++ + + +E + ++
Sbjct: 1333 -QQKNKSMSQAETEGAK 1348
Score = 157 bits (397), Expect = 2e-37
Identities = 306/1502 (20%), Positives = 635/1502 (42%), Gaps = 201/1502 (13%)
Query: 51 QERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY 110
Q+ + ++ +++LK I +++ +L + EA +E +A NK+ +LK + + + K
Sbjct: 231 QKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKN 290
Query: 111 IE---EMKAQGGTVLPTEPQSEEQLSK--HDKSSTEEEMEIEKIKH---KLQEKEELIST 162
I+ E + + + + Q+ +++ E++ EK+KH L+E E S
Sbjct: 291 IQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSI 350
Query: 163 LQAQLT-----QAQAEQPAQ-------SSTEMEEFVMMKQQLQEKEE--FISTLQAQLS- 207
L+ ++T + + E AQ E EF + + L ++E+ I L+++L+
Sbjct: 351 LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410
Query: 208 ----------QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVL 257
Q E + + +K+ + L + E +L +++ ++++ L
Sbjct: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ-GLKEQCENL 469
Query: 258 QRKLEEHEESLVGRAQVVDLLQQELTAA-------------EQRNQI--LSQQLQQMEAE 302
Q++ +E + +++++LQ EL + +Q + + L Q+L+ E
Sbjct: 470 QQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTE 529
Query: 303 HNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESR 362
+ L TV + E++ LL + EL V E + + NLQE+ L Q ELE +
Sbjct: 530 KDALLETVNRLQGENEKLLSQQEL-VPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGK 588
Query: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ--DKNEQAVQSAQTI 420
++L EEK I L+ + +E+ + + + +L+ K EQ +Q +
Sbjct: 589 INSL-------TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSEL 641
Query: 421 QQ--------LEDQLQQKSKEISQFLNRLPLQ-----QHETASQTSFPDVYNEGTQAVTE 467
+Q LE+ L++K + Q L +L +Q + + +Y E + +E
Sbjct: 642 EQKVNELTGGLEETLKEKDQN-DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSE 700
Query: 468 ENIAS--------------LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEA 513
+ S L++ + +LE + ++ L +L ENE++ +
Sbjct: 701 KKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL-LENEQVQKLFVKTQL 759
Query: 514 QNRTGEADREVSEIS----IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEA 569
E EVSE S +V++ S + ++ F + K L L E+K
Sbjct: 760 YGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE-LEKEIKCL 818
Query: 570 QEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIA----PIKMKVFLEDT---GQDF 622
QEE +L+ + +VL +KE+++++ E A ++MK E T Q+
Sbjct: 819 QEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNL 878
Query: 623 PLMPNEESSLPAV-----EKEQA-------------STEHQSRTSEEISLNDAGVELKST 664
+ E S + EKE+ E + R +E I L D+ + S
Sbjct: 879 LIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSV 938
Query: 665 KQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI---YEKNLDEKAKEISNL 721
K D LS+V ++ ++++E L+ + E E +K + + +K LD KE +
Sbjct: 939 KND---PLSSVKEL----EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTV 991
Query: 722 NQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRR 781
+ +E + D S++ RD + +++ E Q +QL++ E ER
Sbjct: 992 KEELESLRSEKDQLSASM------RDLIQGAESYKNLLLEYEKQSEQLDV---EKERANN 1042
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDV--KIEVLQNELDDVQLQFSE----QSTLIRS 835
++ + L + +I + ++D+ +IE LQ+ +++Q E ++ + +
Sbjct: 1043 FEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE 1102
Query: 836 LQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITK-MDQLLLEKKRDVETLQQ 894
L+++ KE ++ E A V +++EEL L +++ ++ K M +L L KK +T
Sbjct: 1103 LEAEKLQKEQKIKEHATTV----NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM 1158
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
+E D + + + +K+ N + L EIK K++ L + + V++ E
Sbjct: 1159 NMEIADYE--RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEE 1216
Query: 955 VSSGLKQ----NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVS 1010
++ +KQ E++ + Q + L + LK E E +++++ I E+
Sbjct: 1217 KNTKIKQLLVKTKKELADSKQAETDHLILQAS-LKGELEASQQQVEVYKIQLAEITSEKH 1275
Query: 1011 RLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKE 1070
++ E L ++ ++ + + ++E+ + + VTS+ + ++ + + +++
Sbjct: 1276 KIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335
Query: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNT 1130
+ + + E E + L+ Q+ LQD N + + +E+ Q+ L+ +
Sbjct: 1336 NKSMS-QAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN 1394
Query: 1131 DASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA---LTSR 1187
+++ETV S E EL EK+ +++ E ++ + + LTS+
Sbjct: 1395 --------KMLQETV--------SKE---AELREKLCSIQSENMMMKSEHTQTVSQLTSQ 1435
Query: 1188 KAILKKA-QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ--VRESI 1244
+L+ + +++ RHL+EE + LQ+Q + QL QL+ + R +
Sbjct: 1436 NEVLRNSFRDQVRHLQEE---HRKTVETLQQQLSKMEA-------QLFQLKNEPTTRSPV 1485
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSV 1304
+ + +E ++ L + E+ ++ ++++ L
Sbjct: 1486 SSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPE- 1544
Query: 1305 AQIKAQLKEIEAEKVELELKVSSTTSE------LTKKSEEVFQ-LQEQINKQGLEIESLK 1357
+++ L E K EL K+SSTT L +++E L EQI EI L+
Sbjct: 1545 TKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLE 1604
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
+ E E A +L+ L++ LQ L+ E + L + ++ E+ L+
Sbjct: 1605 R-NQEREKSAANLEY-LKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQG 1662
Query: 1418 KE 1419
+E
Sbjct: 1663 EE 1664
Score = 145 bits (367), Expect = 5e-34
Identities = 260/1349 (19%), Positives = 553/1349 (40%), Gaps = 218/1349 (16%)
Query: 46 TQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLT 105
T ++++ + + + V + ++ + ++ Q + ER+ + KI +L L + +
Sbjct: 340 TLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGC 399
Query: 106 SLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA 165
+ K E+ T Q ++ + +E E+ + EKE+L +
Sbjct: 400 VIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEI 459
Query: 166 QLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDAR 225
Q + Q E Q E +E ++ + L+E E + QT+ ++A ++ +E
Sbjct: 460 QGLKEQCENLQQ---EKQEAILNYESLREIMEIL--------QTELGESAGKISQE---- 504
Query: 226 FETQVRLHEDELLQLVTQADVETEMQQKLRVLQ--RKLEEHEESLVGRAQVVDLLQQELT 283
FE+ + ++ +L Q + T +K +L+ +L+ E L+ + ++V L+ +
Sbjct: 505 FESMKQQQASDVHEL--QQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIK 562
Query: 284 AAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMH 343
+++N + L Q + L + + EE + K++ E +FH E
Sbjct: 563 NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD-NFHKKCEREE 621
Query: 344 HLL----EQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT----------GQ 389
L+ ++ EQ Q +ELE + + L + ++EK + L+K +
Sbjct: 622 RLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE 681
Query: 390 ELQSACDALKDQNSKLLQDKNE------------QAVQSAQTIQQLEDQLQ---QKSKEI 434
L + +L ++N+KL +K + + V + I QLE +LQ ++ +
Sbjct: 682 VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNL 741
Query: 435 SQFLNRLPLQQ---------------HETASQTSFPDVYN------EGTQAVTEE--NIA 471
++ L +Q+ E + + DV N E + EE N+A
Sbjct: 742 NKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLA 801
Query: 472 -SLQKRVVELENEKGALLLSSI-ELEELKAENEKLSSQITLLEAQNRTGEADREVSEISI 529
++V+ELE E L S+ + EELK+ + LL + ++++E + +
Sbjct: 802 FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDL 861
Query: 530 VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEAD 589
+++ N + E+ LL++++E + + ++ + ++ +
Sbjct: 862 LEMKNANEKTRLENQN----------------LLIQVEEVSQTCSKSEIHNEKEKCFIKE 905
Query: 590 HE----VLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE-SSLPAVEKEQASTEH 644
HE +L+QKE++ E + L+D+ P + N+ SS+ +E++ + E
Sbjct: 906 HENLKPLLEQKELRDRRAE-------LILLKDSLAKSPSVKNDPLSSVKELEEKIENLEK 958
Query: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFH--- 701
+ + EE +N + K++ D S + ++ELE L+S+ +L +
Sbjct: 959 ECKEKEE-KINKIKLVAVKAKKELDSSRKETQTV----KEELESLRSEKDQLSASMRDLI 1013
Query: 702 KAQEIYE----------KNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLS 751
+ E Y+ + LD + + +N IE+ + N++ ++ + + LL+
Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073
Query: 752 QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL-----LTEQIHSLSIEAK 806
+++ L +L +V+ LE+ A+A + L+ E + ++ L ++ +
Sbjct: 1074 RIETLQSNAKL-LEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQ 1132
Query: 807 SKDVKIEVLQNELDDVQ----------LQFSEQSTLIRSLQSQLQNK-------ESEVLE 849
+ +++ EL+ V+ ++ ++ L++ L +L NK E E+
Sbjct: 1133 KEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKI 1192
Query: 850 GAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV--------------ETLQQT 895
++ + ++ L ++ Q E + TK+ QLL++ K+++ +L+
Sbjct: 1193 QKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGE 1252
Query: 896 IEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQ------------LNLLSRAEE 943
+E QQV + E + EK + +KT EQ L
Sbjct: 1253 LEASQQQVEVYKIQLAE----ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRA 1308
Query: 944 AKKEQVEEDNE-------VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQ 996
AK EQ +E V + LKQ ++ Q E + E + L+ +Q K KLQ
Sbjct: 1309 AKAEQATVTSEFESYKVRVHNVLKQQKNK--SMSQAETEGAKQEREHLEMLIDQLKIKLQ 1366
Query: 997 AALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKC-VTSKC 1055
+ N + + + L+ E L + K + + ++ E+ E + C + S+
Sbjct: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELRE--------KLCSIQSEN 1418
Query: 1056 QEIEIYLKQTISEKEVELQHIRKDLEEKLA-AEEQFQALVKQMNQTLQDKTNQIDLLQAE 1114
++ QT+S+ + + +R +++ +E+ + V+ + Q L Q+ L+ E
Sbjct: 1419 MMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE 1478
Query: 1115 ------ISENQAIIQKLITSNTD----------ASDGDSVALV-KETVVISPPCTGSSEH 1157
+S Q++ NTD +G+ + E+V + T S E
Sbjct: 1479 PTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQ 1538
Query: 1158 W----KPELEEKILALEKEKEQLQKKLQEALTSR---KAILKKAQEKERHLREELKQQKD 1210
+ +LE + E KE+L +KL S +L++ + L E++K K
Sbjct: 1539 LLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKS 1598
Query: 1211 DYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
+ RL E+ E+ K N+ + L+ + +Q
Sbjct: 1599 EIRRL-ERNQEREKSAANL-EYLKNVLLQ 1625
Score = 88.6 bits (218), Expect = 9e-17
Identities = 190/959 (19%), Positives = 391/959 (40%), Gaps = 160/959 (16%)
Query: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNK 92
E+ ++S+ + + V E LA + L +K ++L+++ + LQEE +
Sbjct: 769 EVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEE 828
Query: 93 IKKLKLHAKAKLTSLNKYIEEMKAQ----GGTVLPTEPQSEE----------QLSKHDKS 138
+K L + + L K +EE++++ +L + +E+ Q+ + ++
Sbjct: 829 LKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT 888
Query: 139 STEEEMEIEKIKHKLQEKEELISTL-QAQLTQAQAE----------------QPAQSSTE 181
++ E+ EK K ++E E L L Q +L +AE P S E
Sbjct: 889 CSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKE 948
Query: 182 MEEFV-MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD-ARFETQVRLHEDELLQ 239
+EE + ++++ +EKEE I+ ++ A + +E D +R ETQ ++EL
Sbjct: 949 LEEKIENLEKECKEKEEKINKIKL---------VAVKAKKELDSSRKETQT--VKEELES 997
Query: 240 LVTQADVETEMQQKLRVLQRKLEEHEESLV---GRAQVVDLLQQELTAAEQRNQILSQQL 296
L ++ D ++ +R L + E ++ L+ +++ +D+ ++ E R + L++QL
Sbjct: 998 LRSEKD---QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQL 1054
Query: 297 -------QQMEAEHNTLRNTVETEREESKILLEKMELEV------AERKLSFHNLQEEMH 343
+ + +++ L +ET + +K LLE LEV +++L LQ+E
Sbjct: 1055 RNSTLQCETINSDNEDLLARIETLQSNAK-LLEVQILEVQRAKAMVDKELEAEKLQKE-- 1111
Query: 344 HLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS 403
++ ++ ELE L+++ K LQKT QEL+ KD
Sbjct: 1112 ---QKIKEHATTVNELEELQVQLQKEKK-----------QLQKTMQELEL---VKKDAQQ 1154
Query: 404 KLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ 463
L N + + +++L +L K+ +I + +Q+ + Q
Sbjct: 1155 TTLM--NMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQK---------------Q 1197
Query: 464 AVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
+E I SLQ V + E + + ++ ++ A++++ + +L+A + GE +
Sbjct: 1198 ETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK-GELEAS 1256
Query: 524 VSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
++ + I +S + + L+ + Q + LS + QEE K +
Sbjct: 1257 QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATV 1316
Query: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
+E ++V +KQ + + ++ QA TE
Sbjct: 1317 TSEFESYKVRVHNVLKQQKNKSMS-------------------------------QAETE 1345
Query: 644 --HQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI-----LEL 696
Q R E+ ++ ++L+ ++ + ++S + + H LER + E
Sbjct: 1346 GAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA 1405
Query: 697 ELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL 756
EL K I +N+ K++ ++QL + + ++ L EE + + +++
Sbjct: 1406 ELR-EKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQ- 1463
Query: 757 SMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQ 816
++++ AQ+ QL + E R SQ + NL + L + + E
Sbjct: 1464 -QLSKMEAQLFQL-----KNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEG 1517
Query: 817 NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEIT 876
E D + S ST +SL+ L + E+++ + H EEL Q LS
Sbjct: 1518 METTDTE-SVSSASTYTQSLEQLLNSPETKL---EPPLWHAEFTKEELVQKLSSTTKSAD 1573
Query: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL 935
++ LL E + L + I+ ++ + ++ N+E+ ++ LK L
Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSEI---------RRLERNQEREKSAANLEYLKNVL 1623
Score = 70.1 bits (170), Expect = 3e-11
Identities = 173/891 (19%), Positives = 357/891 (40%), Gaps = 101/891 (11%)
Query: 31 DPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIR--QKDVQLQQKDEALQEERKA 88
+ E Q +E N ++ E + L+++++++ + K +K++ +E +
Sbjct: 853 EKEALQSDLLEMKNANEKTRLEN----QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHEN 908
Query: 89 ADNKIKKLKLH-AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIE 147
+++ +L +A+L L + + + L + + EE++ +K E+E +I
Sbjct: 909 LKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKIN 968
Query: 148 KIK-HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEF-VMMKQQLQEKEEFISTLQAQ 205
KIK ++ K+EL S+ + TQ E+ +E ++ M+ +Q E + + L
Sbjct: 969 KIKLVAVKAKKELDSSRKE--TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026
Query: 206 LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265
Q++ ++ + R E R + LQ T ++ ++ LQ + E
Sbjct: 1027 EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLE 1086
Query: 266 ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKME 325
++ + ++ +EL A + Q +Q EH T N LE+++
Sbjct: 1087 VQILEVQRAKAMVDKELEAEK-------LQKEQKIKEHATTVNE-----------LEELQ 1128
Query: 326 LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQ 385
+++ + K +E+ + + +Q E+ + Y L ++ ++ K + I L
Sbjct: 1129 VQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEI-ADYERLMKELNQKLTNKNNKIEDL- 1186
Query: 386 KTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ 445
+Q K+ + K E + ++Q Q ++K+ +I Q L + +
Sbjct: 1187 --------------EQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVK---TK 1229
Query: 446 HETASQTSFPDVYNEGTQAVTEENI--ASLQKRVVELENEKGALLLSSIELEELKAENEK 503
E A + QA T+ I ASL+ ELE + + + I+L E+ +E K
Sbjct: 1230 KELA----------DSKQAETDHLILQASLKG---ELEASQQQVEVYKIQLAEITSEKHK 1276
Query: 504 LSSQI-TLLEAQNRTGEADRE-----VSEISIVDIANKRSSSAEESGQDVLENTF-SQKH 556
+ + T E RT A ++ E +S ES + + N QK+
Sbjct: 1277 IHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN 1336
Query: 557 KELSVLLLE-MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKM--KV 613
K +S E K+ +E + L QL+ K + ++ ++ E++ ++ E ++ K+
Sbjct: 1337 KSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396
Query: 614 FLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
E ++ L E+ E +EH S+ S N+ L+++ +D
Sbjct: 1397 LQETVSKEAEL--REKLCSIQSENMMMKSEHTQTVSQLTSQNEV---LRNSFRD------ 1445
Query: 674 AVPDIGQCHQDELERLKSQILELELN-FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNA 732
V + + H+ +E L+ Q+ ++E F E ++ + + NL + ++N
Sbjct: 1446 QVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRE-----RRNT 1500
Query: 733 DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
D ++ E + + + + V+ + LE L E + E H
Sbjct: 1501 DLPLLDMHTVTREEGEGM-ETTDTESVSSASTYTQSLEQLLNSPETK----LEPPLWHAE 1555
Query: 793 LLTEQ-IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGA 851
E+ + LS KS D + L E + EQ L++S +L+ + A
Sbjct: 1556 FTKEELVQKLSSTTKSAD-HLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAA 1614
Query: 852 --ERVRHISSKVEELSQALSQKEL--EITKMDQLLLEKKRDVETLQQTIEE 898
E ++++ + L ++ L I M QL E+K + + Q EE
Sbjct: 1615 NLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEE 1665
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 225 bits (574), Expect = 5e-58
Identities = 408/1893 (21%), Positives = 778/1893 (41%), Gaps = 247/1893 (13%)
Query: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDE 80
+ DQ P D +L +E QE +E EQ E ++ + Q+D Q++DE
Sbjct: 116 EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS--EKQERLEQRD--RQRRDE 171
Query: 81 AL---------QEERKAADNKIKKLKLHA-----------KAKLTSLNKYIEEMKAQGGT 120
L +EER+A + +++ K H + +L L + E K Q
Sbjct: 172 ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRR 231
Query: 121 VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHK-------LQEKEELISTLQAQ--LTQAQ 171
EE+ + K T E EK++ + LQE+EE + L+ Q + Q
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ 291
Query: 172 AEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQ-LSQTQAEQAAQQVVREKDARFETQV 230
E+ Q E+ + KQ+ + +E+ + Q + Q E+ QQ+ RE++ R E Q+
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 231 RLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290
R ++E + Q E E +++ + L+R+ + E + R Q + QQ + R +
Sbjct: 352 RREQEEERR-EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410
Query: 291 ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL----EVAERKLSFHNLQEEMHHLL 346
++ QQ+ E LR E ER E K E+ E E ER+ +E H
Sbjct: 411 QQLRREQQLRREQQ-LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469
Query: 347 EQFEQAGQAQAELESRYSAL--------------EQKHKAEMEEKTSHILSLQKTGQELQ 392
E+ +Q + E E R L EQ+ + E EE+ L Q+ + LQ
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 393 SACDA----------------LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ 436
+ +++ +L Q++ EQ ++ Q ++ DQL ++ +E Q
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ--EERRDQLLKREEERRQ 587
Query: 437 FLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEE 496
RL +Q E Q + E + + +E + + E E E+ LL S E EE
Sbjct: 588 --QRLKREQEERLEQR----LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 497 LKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSS-AEESGQDVLENTFSQK 555
+ + + Q + R E +R + +R AEE + E S+
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI 701
Query: 556 HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMK-QMEGEGIAPIKMKVF 614
K L E Q ++ + +G+R + E ++E + Q + E A + +
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE- 760
Query: 615 LEDTGQDFPLMPNEE----------SSLPAV----EKEQASTEHQSRTSEEISLNDAGVE 660
E+ +DF E S+ P + E++ + E Q R + + +
Sbjct: 761 -EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819
Query: 661 LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISN 720
+ +++ +K L + + +++L+R + + +L+ QE E+ ++ +
Sbjct: 820 RRRQRREREKELQFLEE-----EEQLQR-RERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 721 LNQLIEEFKKNADNNSSAFTALSEE---RDQLLSQVKELSMVTELRAQVKQLEMNLAEAE 777
+EE +K + A AL E+ QLL + +E E+ E E
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE--------------ELQREERE 919
Query: 778 RQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ 837
++RR + E Q + L ++ L E + K + E + D +LQ E+ L +
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 838 SQLQNKESEVLEGAERVRHISSKV--EELSQALSQK-ELEITKMDQLLLEKKRDVETLQQ 894
+ + + + E ++ ++ EE + Q+ E + K D+L E++ + L++
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE---QLLRE 1036
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
E++ Q E + E++ Q EE+ LG E +T + Q +E + +Q EE
Sbjct: 1037 EREKRRLQERERQYREEEELQQ--EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL 1094
Query: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
K+ E + +EELQ E + L +E +++R+ + R+E + V + EE
Sbjct: 1095 REEPEKRRRQERERQCR-EEEELQQEEEQLLREEREKRRRQELERQYREE--EEVQQEEE 1151
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
+L + E ++ L R E E +E ++ + + QE E +Q E+E++ Q
Sbjct: 1152 QLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE---RQYREEEELQRQ 1208
Query: 1075 HI---------RKDLEEKLAAE-----------------EQFQALVKQMNQTLQDKTNQI 1108
R DL+ + E EQF+ L + L+D+ +Q
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE---DSQLRDRQSQQ 1265
Query: 1109 DL--LQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP----EL 1162
DL L E E ++ D + L +E + S+ K E
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER 1325
Query: 1163 EEKILALE-----KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE 1217
EEK E +E+EQL ++ +E R+ +K +E+E +E+ ++ ++ RL+
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR 1385
Query: 1218 QFDEQS--KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Q E+ KE + + Q R+ Q+ R+ D K +QQ S + F+ EQ
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQL--RQDRDRKFREEEQQLSRQE----RDRKFREEEQQV 1439
Query: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
+ E + ++ + Q+ + +E + + E + K +L ++
Sbjct: 1440 RRQERERKFLEEEQQLRQERH--RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL--ESSQL--QIAGLEHLRELQ 1391
+ ++++ Q E K + E ++H + Q+K E QL Q G + ++
Sbjct: 1498 ERDRKFREQELRSQEPE---RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 1392 PKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQA---- 1447
K E ++L ++EE LS Q +++ L + + EQE QL Q
Sbjct: 1555 RKFREEEQLRQEREEQ--QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612
Query: 1448 --KEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK---ENKSL 1502
+E D + ++ + L E ++ +++ + R ++ ++ + Q R++ L+ + K
Sbjct: 1613 LRQERDRKFREDEQLLQEREE--QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670
Query: 1503 QEELSLARGTIERLTKSLAD-----VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557
+EE L G ++L + D E Q+ Q +E+ LQEE+ E++R
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK-------FLQEEQQLRRQELER 1723
Query: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617
E + L E +L +++ + + E E L+ + + QE+ ++ ++E
Sbjct: 1724 KFREEEQLRQETEQEQLR----RQERYRKILEEEQLRPEREEQQLRRQERDRKFREE--- 1776
Query: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677
E +RQE++E +LRS E+++K E++ E+E ++++ +
Sbjct: 1777 -------------------EQLRQEREEQ--QLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737
R +++ L+LEE+ RLR E D E + S +EE E + E +
Sbjct: 1816 QRDGKYRWEEEQLQLEEQEQRLRQE----RDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Query: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQ 1770
++ + + E+ ++ ++ +H+ G + Q
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Score = 210 bits (535), Expect = 2e-53
Identities = 379/1879 (20%), Positives = 769/1879 (40%), Gaps = 242/1879 (12%)
Query: 1465 KQKPEEIGEESRAKQQIQRK--LQAALISRKEALKENKSLQ---EELSLARGTIERLTKS 1519
+Q EE G+ R K+Q Q + + S K+ E + Q EEL R + +
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER 186
Query: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579
A+ E S + E + L + E + E+ R E + ++ E
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRRE----LLELRRKGREEKQQQRRERQDRVFQEEE 242
Query: 1580 TEDKEK----LVKEIESLKSSKIAESTEWQEKHKELQK-EYEILLQSYENVSNEAERIQH 1634
++ K L KE E L+ + E QE+ ++L+K E + L + + + +R++
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Query: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
+ R++++E ++E +Q + EQ+ E ++++R+ + ++++ L E+
Sbjct: 303 EQQLRRKQEEE-------RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Query: 1695 ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE 1754
E +R ++ + + + +++L R E ++ Q L E+ E
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRR-----EQQLRREQQLRREQQLRRE 410
Query: 1755 EVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSES 1814
Q L+ + + +Q E E+ Q + E Q + E EE+ T
Sbjct: 411 --QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 1815 VPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF--SQTLENEKNT 1872
K + +D Q ++ +ER LEEE+++ ++ Q L E+
Sbjct: 469 QERRKQQ---LKRD------------QEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 1873 LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
Q + E + LQ+ + L ++ +E ++ K +E E++ E+RL + E
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
+ ++ ++K E E + LK+ EE ++L +E+ + E +++E E
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKR------EEVERLEQEERR-EQRLKREEPE 626
Query: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
+ + Q + + Q+L +E+Q+ +Q K R +E+ ER + L+ E
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLK---REEEE----ERLEQRLKREHEEE 679
Query: 2053 QKDLEITKENLAQAVEHRK----------KAQAELASFKVLLDDTQSEAARVLADNLKLK 2102
+++ E+ +E QA E K +++A+ KV + E R + + +
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739
Query: 2103 KELQSN---KESVKSQMKQKDEDLERRLE---QAEEKH------------LKEKKNMQEK 2144
+ +S +E ++ +Q++E+ R QAEEK L+E++ Q +
Sbjct: 740 RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 2145 LDALRREKVHL---EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLA-AFTKSMSSLQDD 2200
+ ++ + EE + + +++KE+Q L+E + A + LQ+D
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD 2260
++R + ++ ++K+ ++ + + R L++QLR+ ++E + + R E +
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Query: 2261 K---QIWESKAQTEVQLQQ----------------------KVCDTLQGENKELLSQLEE 2295
K Q E + + E QLQQ + LQ + ++LL + E
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
R + + + E EL+ ++QL L EK + Q+ + ++ E + +
Sbjct: 980 KRR--RQEREKKYREEEELQQEEEQL--LREEREKRRRQEWERQ-YRKKDELQQEEEQLL 1034
Query: 2356 YEQLETDLQASRELTSRLHEEINMKEQKI------------ISLLSGKEEAIQVAIAEL- 2402
E+ E RE R EE+ +E+++ + KEE +Q +L
Sbjct: 1035 REEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLL 1094
Query: 2403 --------RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454
RQ+ +++ +E E L Q+EEE ++ EE K+ + + + +++E Q
Sbjct: 1095 REEPEKRRRQERERQCREEEEL--QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 2455 ---------QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAEN 2505
++ +L+ + LQ + ++++ + Q+ + +++ +Q +
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 2506 NKLKEEIRGLRSHMDDLNSENAKLDAELI-------QYREDLNQVITIKDSQQ--KQLLE 2556
E+ R + ENA D ++ Q+R+ + + + SQQ + LL
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 2557 VQLQQNKELENKYAKL------EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVS 2610
Q ++++E E + + EE+ E EE E RR + QEEKQ L +E E +
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS-QEEKQLLREEREEKRRR 1331
Query: 2611 IS-----QLTRQVTALQEEGTLGLYHAQLKVKEEEV--HRLSALFSSSQKRIAELEEELV 2663
+ Q+ +EE L K +EEE+ F ++R+ E E
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391
Query: 2664 CVQKEAAKKVGEIEDKLK--KELKHLHHDAGIMRNETETA-EERVAELARDLVEMEQKLL 2720
+++E + E E +L+ ++ K + + R E + E ++ R E E+K L
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ--ERERKFL 1449
Query: 2721 MVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780
+E + L + R L R+ E RK+ L+E QL+ Q +
Sbjct: 1450 ---EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF---LEEEQQLRRQERDRKF 1503
Query: 2781 RDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMAS 2840
R+ L EE H ++ ++ L +++QL + ++ + F +
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 2841 LQNERDHLWNELEKFRK--SEEGKQRSAAQPSTSPAEVQSLKK--AMSSLQNDRDRLLKE 2896
Q + + E+ RK EE K R Q + Q L++ L+ +RDR +E
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 2897 LKNLQQQYLQINQEITELHPLKAQLQEYQDKTK-AFQIMQEELRQENLSWQHELHQLRME 2955
+ L Q+ +E +LH + + +++ + Q +++LR + E QL E
Sbjct: 1624 DEQLLQE-----REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 2956 KSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSA 3015
++ + ++ +++QQL + RE + + Q + + +R+ E
Sbjct: 1679 GEEQQLRRQERDRKF----REEEQQLRRQE---RERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 3016 SPDGSQNLVYETELLRTQLNDS--LKEIHQKELRIQQLNSNF---SQLLEEKNTLSIQLC 3070
+ Q + E R L + E +++LR Q+ + F QL +E+ ++
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 3071 DTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR-------- 3122
++ + RE +Q E++ Q+L+ PQ+++G +R
Sbjct: 1792 ESDRKFREEEQ---------LRQEREEQQLR------------PQQRDGKYRWEEEQLQL 1830
Query: 3123 KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
+ + LR+ + A++Q + E ++L +EE +Q+ E + EE IRR +
Sbjct: 1831 EEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEE-EQKRRQERERKLREEHIRRQQ 1889
Query: 3183 HSEWDSSRTPIIGSCGTQE 3201
E R +G +QE
Sbjct: 1890 KEE---QRHRQVGEIKSQE 1905
Score = 206 bits (525), Expect = 2e-52
Identities = 397/2007 (19%), Positives = 816/2007 (40%), Gaps = 217/2007 (10%)
Query: 92 KIKKLKLHAKAKLTSLNKYIEEMKAQGG---TVLPTEPQSEEQLSKHDKSSTEEEMEIEK 148
K+ + +A + T L+ EE +A+ ++L Q E+Q + EE ++
Sbjct: 80 KVAQACYYALGQATGLD---EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR 136
Query: 149 IKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQ 208
+ K QE+E ++ + Q + + + EE +Q+ QE+EE +
Sbjct: 137 RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREE----------R 186
Query: 209 TQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESL 268
E+ Q + F + +L ELL+L + E + Q++ R + EE E+
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246
Query: 269 VGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTL-RNTVETEREESKILLEKMELE 327
R V+ +++L E + Q ++LQ+ E + L R + ER+E E+ + +
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQ---RELQEEEEQLRKLERQELRRERQE-----EEQQQQ 298
Query: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387
R+ QEE EQ E+ + Q E + EQ+ + E EE+ L ++
Sbjct: 299 RLRREQQLRRKQEEERR--EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
+ + +++ + Q + EQ ++ Q +++ E QL+++ Q L R + E
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRR-EQQLRRE-----QQLRREQQLRRE 410
Query: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQ 507
Q E+ + Q+ E E E+ E K E E+ +
Sbjct: 411 --------------QQLRREQQLRREQQLRREQEEER----------HEQKHEQERREQR 446
Query: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567
+ + + R E +E +E + L+ ++ +E L LE +
Sbjct: 447 LKREQEERRDWLKREEETE-----------RHEQERRKQQLKRDQEEERRE-RWLKLEEE 494
Query: 568 EAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627
E +E+ + QL+ ++ E + + Q+E ++++ + +++ E+ + L
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL-LKRE 553
Query: 628 EESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE 687
EE L +EQ Q +++ LK ++ + L +++ E
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQL--------LKREEERRQQRLK---------REQEE 596
Query: 688 RLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERD 747
RL+ ++ E+ + +E E+ L + E QL++ ++ E R+
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 748 QLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS------- 800
Q L + +E ++LE L + R + E E+I S
Sbjct: 657 QRLKREEE----------EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706
Query: 801 -LSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS 859
L EA ++ K+ + + Q + EQ R +S+LQ +E E A R +
Sbjct: 707 QLESEADARQSKV-YSRPRKQEGQRRRQEQEEKRRRRESELQWQEE---ERAHRQQQEEE 762
Query: 860 KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE 919
+ + + +E +L + +Q E+ QQ + E+ Q
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 920 EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQH 979
++ E++ L+E+ L R E A++ Q EED GL+++ + Q ++ +
Sbjct: 823 QRREREKELQFLEEE-EQLQRRERAQQLQEEED-----GLQEDQERRRSQEQRRDQKWRW 876
Query: 980 EFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEE 1039
+ L++E ++R+ L A +++L + L+EE L+ E +++ E ER + E
Sbjct: 877 Q---LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER-QYRE 932
Query: 1040 DKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQ 1099
+++ ++ E+ + + ++ ++ K+ +LQ + L + + + Q K+ +
Sbjct: 933 EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992
Query: 1100 TLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWK 1159
+ + + LL+ E + + + D + L++E E K
Sbjct: 993 EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE------------EREK 1040
Query: 1160 PELEEKILALEKEKEQLQKKLQ----EALTSRKAILKKAQEKERHLREELKQ--QKDDYN 1213
L+E+ +E+E Q++ Q E T R+ L++ KE L++E +Q +++
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQ 1273
R +++ + Q +E E + + QL + RE + +E EE L + +
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE-EEVQQEEEQLLREEPE 1159
Query: 1274 HHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELT 1333
+ LE + E+ L+ + + + + E E+++ + + E
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE-D 1218
Query: 1334 KKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPK 1393
++S+ +Q + + + + + E E + +L Q Q L+HL Q +
Sbjct: 1219 QRSDLKWQWEPE-KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ-QDLQHLLGEQQE 1276
Query: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDER 1453
D Q+ ++ D + + E+E + + QE+ QL + +E R
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE------KQLLREEREEKRR 1330
Query: 1454 IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTI 1513
++ + E +Q +E E+ +Q+ RK + + +E + K L+EE L R
Sbjct: 1331 RQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE--QGRKFLEEEQRLRRQ-- 1386
Query: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLK 1573
ER K L + E Q+ Q +E+ L+++RD+ E E Q LS K
Sbjct: 1387 ERERKFLKE-EQQLRCQEREQQ--------LRQDRDRKFRE------EEQQLSRQERDRK 1431
Query: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ 1633
++E+ V+ E + E QE+H++ ++E ++L + E + ER +
Sbjct: 1432 F------REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 1634 HVVEAVRQ-EKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILEL 1692
+E +Q +QE K R E +E E++ E EQ++ +++ RKF + +QQ L
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR-QQRQRKFLQEEQQ--LRR 1542
Query: 1693 EEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSL 1752
+E + R + ++ + S +E + ++E + + ++ ++
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ-----EQERKF 1597
Query: 1753 SEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS 1812
E+ Q L+ Q EG + + + D Q E Q +E+D + P
Sbjct: 1598 MEDEQQLRRQ-EGQQQLRQERDRKFREDEQLLQEREEQQL---HRQERDRKFLEEEPQLR 1653
Query: 1813 ESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNT 1872
+ HD + ++ L+E EE++ + +E + E+
Sbjct: 1654 RQEREQQ----------LRHDRDRKFREEEQLLQEG----EEQQLRRQERDRKFREEE-- 1697
Query: 1873 LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
Q+ ++ E K LQEE L Q+++ + +L++ E+E+ +ER L E
Sbjct: 1698 --QQLRRQERERKFLQEE---QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE 1752
Query: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE--KQQLVKEKTKVESEIRKEY 1990
+ + Q++ + + + + ++ E EE+ + Q K + E ++R+E
Sbjct: 1753 -----EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Query: 1991 LEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK-ALEFVQ 2049
E+ Q+ G K +E Q L+E++Q ++Q + R +E+ + E++ + E Q
Sbjct: 1808 EEQQLRPQQRDG-KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ 1866
Query: 2050 TESQKDLEITKENLAQAVEHRKKAQAE 2076
E QK + + L + EH ++ Q E
Sbjct: 1867 EEEQKRRQERERKLRE--EHIRRQQKE 1891
Score = 157 bits (397), Expect = 2e-37
Identities = 260/1336 (19%), Positives = 549/1336 (41%), Gaps = 155/1336 (11%)
Query: 16 LSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQL 75
L ++ ++ + L E +E + Q++ +E+ E+ L+ ++++ +
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Query: 76 QQKDEALQEERKAADNKIK------KLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSE 129
+++ E +EE++ A +IK + +L ++A Y K +G + + +
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG------QRRRQ 733
Query: 130 EQLSKHDKSSTEEEMEIEKIKHKLQEKEE---------------------------LIST 162
EQ K + +E + + E+ H+ Q++EE L
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 163 LQAQLTQAQAEQPAQS-STEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVRE 221
+ QL + +Q Q E EE ++Q +E+E+ + L+ + Q Q + AQQ+ E
Sbjct: 794 RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE-EQLQRRERAQQLQEE 852
Query: 222 KDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQE 281
+D E Q R E Q++ + + +LEE + LQ++
Sbjct: 853 EDGLQEDQERRRSQE--------------QRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898
Query: 282 LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEE 341
L +Q Q ++LQ+ E E + REE ++ E+ +L ER+ +E
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 342 MHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQ 401
+ ++ +Q + E E++ + E E+K LQ+ ++L L+++
Sbjct: 959 QYRKDKKLQQKEEQLLGEEP-----EKRRRQEREKKYREEEELQQEEEQL------LREE 1007
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
K + + E+ + +QQ E+QL ++ +E + R + E Q + E
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+ + + ++ EL+ E+ LL E + + + L + + + +
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 522 REVSEISIVDIANKRSSSAEESGQDVL-ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
RE ++ + ++ + +L E ++ +EL E +E Q+E L +
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
Q KR +E + + +++E+++ K K D Q L E EKE A
Sbjct: 1188 QEKRRQERERQYREEEELQRQ--------KRKQRYRDEDQRSDLKWQWEP-----EKENA 1234
Query: 641 STEH----QSRTSEEI-SLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
++ + R +E+ L D+ + + ++QD L + + + + + +
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFP 1294
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755
E + ++ K D K++E L + E K+ F E +QLL + +E
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF----REEEQLLQEREE 1350
Query: 756 LSM----------VTELRAQVK-----QLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS 800
+ ELR Q + + E L ER+R+ E Q +Q+
Sbjct: 1351 QPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR- 1409
Query: 801 LSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSK 860
+ + + + E Q + +F E+ +R + + + E E ER R +
Sbjct: 1410 ---QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 861 VEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEE 920
E+L Q +++L + D+ LE+++ + +E+D++ E E + EE
Sbjct: 1467 -EQLLQEREEQQLHRQERDRKFLEEEQQLRR-----QERDRKFREQELRSQEPERKFLEE 1520
Query: 921 KFSLGVEIKTLK--EQLNLLSRAEEAKKEQVEEDNEV--SSGLKQNYDEMSPAGQISKEE 976
+ L + + K ++ L R E ++ + + D + L+Q +E Q+S++E
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ----QLSRQE 1576
Query: 977 LQHEFDL----LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET 1032
+F L ++++ ++RK + R+E Q++ R E + +DE L E
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL-RQERDRKFREDEQL----LQER 1631
Query: 1033 ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
E ++ + ++++ E+ + QE E L+ K E + + ++ EE+ ++
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152
++ Q L+ + + LQ E Q+L + + L +ET
Sbjct: 1692 KFREEEQQLRRQERERKFLQEE--------QQLRRQELERKFREEEQLRQET---EQEQL 1740
Query: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK--------KAQEKERHLREE 1204
E ++ LEE+ L E+E++QL+++ ++ + L+ ++QE +R REE
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800
Query: 1205 --LKQQKDDYNRLQEQFDEQSK-ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP 1261
L+Q++++ +Q D + + E E + QL + + ++R+ D + + +Q + +
Sbjct: 1801 EQLRQEREEQQLRPQQRDGKYRWEEEQL--QLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858
Query: 1262 GLEEPLFKATEQHHTQ 1277
E+ L++ EQ Q
Sbjct: 1859 REEQELWQEEEQKRRQ 1874
Score = 139 bits (349), Expect = 6e-32
Identities = 267/1298 (20%), Positives = 542/1298 (41%), Gaps = 205/1298 (15%)
Query: 30 LDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAA 89
L E Q+ + F +E Q R E+ EL+ + ++ +Q +++ + LQEE
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRRER-EKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 90 DNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI--- 146
++ + + + +EE + + L +P +EQL K + EEE E+
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 147 EKIKHKLQEKE------ELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIS 200
E+ K + QE+E E + + QL + + E+ + E E ++LQ+KEE
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ--ERERQYRKDKKLQQKEE--- 971
Query: 201 TLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK 260
QL + E+ +Q REK R E +++ E++LL+ + E +++ R + +
Sbjct: 972 ----QLLGEEPEKRRRQE-REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK-KDE 1025
Query: 261 LEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT---------LRNTVE 311
L++ EE L+ + LQ+ + ++ ++ Q + E T R E
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 312 TEREESKILLEKMELEVAERK----LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE 367
++EE ++L E+ E + + LQ+E LL + E+ + + ELE +Y E
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE-EREKRRRQELERQYR--E 1142
Query: 368 QKHKAEMEEKTSHILSLQKTGQELQSAC---DALKDQNSKLLQDKNEQAVQSAQTIQQLE 424
++ + EE+ ++ QEL+ + L+ + +LL+++ E+ Q + + E
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 425 DQLQQKSKE--ISQFLNRLPLQ-QHETASQTSFPD--VYNEGTQAVTEENIASLQKRVVE 479
++LQ++ ++ R L+ Q E + + D VY +G + ++ +
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE----------NEQFRQ 1252
Query: 480 LENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI-----AN 534
LE+ + S +L+ L E ++ + + + R + DR E ++ A
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDRE----QERRRWQQRDRHFPEEEQLEREEQKEAK 1308
Query: 535 KRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLD 594
+R ++E Q + E ++ ++ + + K +EE + + Q R +E D + +
Sbjct: 1309 RRDRKSQEEKQLLREEREEKRRRQET----DRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL 654
++ Q +G + ++ ++ + F EE L E+EQ + + R E
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFL---KEEQQLRCQEREQQLRQDRDRKFRE--- 1418
Query: 655 NDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEK 714
E + ++Q+ D+ ++E ++++ Q E E F + ++ + K
Sbjct: 1419 ----EEQQLSRQERDRKF----------REEEQQVRRQ--ERERKFLEEEQQLRQERHRK 1462
Query: 715 AKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM-VTELRAQVKQL---- 769
+E L Q EE + + F EE QL Q ++ ELR+Q +
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFL---EEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 770 -EMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE 828
E L +RQR+ E Q +Q + K + E L+ E ++ QL E
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ---DRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 829 QSTLIRSLQSQLQNKESE--VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKK 886
+ R + +++ +E E +E +++R +E Q L Q+ + D+ LL+++
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRR-----QEGQQQLRQERDRKFREDEQLLQER 1631
Query: 887 RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKK 946
+ + +Q + K + E E+ QL ++ + +E+ LL EE +
Sbjct: 1632 EEQQLHRQERDRKFLE-EEPQLRRQEREQQLRHDRD------RKFREEEQLLQEGEEQQL 1684
Query: 947 EQVEEDN---EVSSGLKQNYDE---MSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI 1000
+ E D E L++ E + Q+ ++EL+ +F +E EQ +++ + +
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF----REEEQLRQETEQEQL 1740
Query: 1001 NRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI 1060
R+E +++ LEEE + E ++++ E +R EE++ +E E+ + S+ + +
Sbjct: 1741 RRQERYRKI--LEEEQLRPERE-EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797
Query: 1061 YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQA 1120
++ + ++ E Q + + K EE+ L +Q + Q++ Q +E Q
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR------AEEQF 1851
Query: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
Q+ K EE+ L E+E+
Sbjct: 1852 ATQE----------------------------------KSRREEQELWQEEEQ------- 1870
Query: 1181 QEALTSRKAILKKAQEKERHLREE-LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
K+ QE+ER LREE +++Q+ + R ++ + +S+E + G L
Sbjct: 1871 -----------KRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE----- 1914
Query: 1240 VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQ 1277
P T Q +S P PL++ ++ +Q
Sbjct: 1915 ---------PGTHQ---FASVPVRSSPLYEYIQEQRSQ 1940
Score = 138 bits (348), Expect = 8e-32
Identities = 255/1281 (19%), Positives = 516/1281 (40%), Gaps = 147/1281 (11%)
Query: 1972 KQQLVKEKTKVESEIRKE----YLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKD 2027
K+ L++++ + E + R E LE+ G ++ + +EL E ++ +++ + Q+D
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 2028 CIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDT 2087
R E++ + + E + E ++ + + + + EL + +
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDA 2147
+ + R D + ++E KE K + + E E +L++ E + +E + +E+L
Sbjct: 226 KQQQRRERQDRVFQEEE---EKEWRKRETVLRKE--EEKLQEEEPQRQRELQEEEEQLRK 280
Query: 2148 LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207
L R+++ E E Q ++++++++ QE + + Q++R R
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER-REQQL 339
Query: 2208 AKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQI-WES 2266
++ E + ++ ++EE R ++ +++ R+ + E+ +L ++Q+ E
Sbjct: 340 RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 2267 KAQTEVQL---QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTD 2323
+ + E QL QQ + ++L + EE R H ++E + E LK +++ D
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEER---HEQKHEQERREQRLKREQEERRD 456
Query: 2324 LSNSLEKCK--EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE 2381
E+ + EQ+ + + R QE + + E+ E Q R E+ +E
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Query: 2382 QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV------ 2435
Q++ +EE +Q + +Q ++ + E LL +EEE+ + E ++
Sbjct: 517 QRL--KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 2436 ------------------DKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV 2477
++ +L + LK + E ++Q+ + + +K + R +++
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 2478 GDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYR 2537
+Q E R + E+ + ++ + + + L+ ++ E + E Q R
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Query: 2538 EDLN--------QVITIKDSQQKQLLEVQLQQ-----NKELENKYAKLEEKLKESEE--- 2581
E + Q+ + D++Q ++ +Q +E E K + E +L+ EE
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 2582 ----ANEDLRRSF--NALQEEKQDLSKEIESLKVSI-SQLTRQVTALQEEGTLGLYHAQL 2634
E+ RR F EEK + ++ S + + Q RQ+ A + + +
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR----EQRF 810
Query: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694
+EEE + +K + LEEE ++E A+++ E ED L+++
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED----------- 859
Query: 2695 RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754
+ + E+R + R +E E+K T K A + + LQ + E
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK--PALQEQLRKEQQLLQEEEEELQREE 917
Query: 2755 DELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKD 2814
E +R+ + + Q +E+ L +E + LL E E +K QQ K+
Sbjct: 918 REKRRRQE----QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ---KE 970
Query: 2815 EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPA 2874
EQLL + + + + + Q E L E EK R+ E +Q
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ----------- 1019
Query: 2875 EVQSLKKAMSSLQNDRDRLL---KELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF 2931
+ LQ + ++LL +E + LQ++ Q +E EL + QL + +T+
Sbjct: 1020 -----YRKKDELQQEEEQLLREEREKRRLQERERQYREE-EELQQEEEQLLGEERETRRR 1073
Query: 2932 QIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIREL 2991
Q ++ + R+E Q E LR E E+R +++ ++++ + L+RE
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEP------EKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 2992 RSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQL 3051
R + + +RQ E + Q L E E R Q E+ ++ ++L
Sbjct: 1128 REKRR-----RQELERQYREEEEVQQEEEQLLREEPEKRRRQ------ELERQYREEEEL 1176
Query: 3052 NSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAP 3111
QLL E+ + + RE Q + L ++ E Q L
Sbjct: 1177 QQEEEQLLREEQ-------EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ--- 1226
Query: 3112 GAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLL--EEERD-----QR 3164
P+++N V + RE +Q F + + RQ +L+ LL ++ERD +R
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQ-FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Query: 3165 VAAENALSVAEEQIRRLEHSE 3185
+ EEQ+ R E E
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKE 1306
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 223 bits (567), Expect = 3e-57
Identities = 362/1638 (22%), Positives = 684/1638 (41%), Gaps = 246/1638 (15%)
Query: 1493 KEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI 1552
K+ L + +S ++EL L +L L + ++Q++ + D RLALL E++
Sbjct: 220 KKQLADERSNRDELELELAENRKL---LTEKDAQIAMMQQRID----RLALLNEKQAA-- 270
Query: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
S LE + L E L+ E LT + +K+ + LK+ K ++ K +L
Sbjct: 271 -----SPLEPKEL----EELRDKNESLTMRLHETLKQCQDLKTEK----SQMDRKINQLS 317
Query: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQE-- 1670
+E L ++ +++Q + + +E + + +A + EK+L A Q+
Sbjct: 318 EENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA---QLEKELSAALQDKK 374
Query: 1671 -MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD-----TAKECMETLLSSNASM 1724
+EE E ++ ++ + +L++ + + EV GD T K+ TL ++N +
Sbjct: 375 CLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEV--LGDVLQLETLKQEAATLAANNTQL 432
Query: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
+ +E ++ E K L++E+ EE Q L I S +NL +
Sbjct: 433 QARVEMLETERGQQEAK---LLAERGHFEEEKQQLSSLITDLQSSISNLSQAK------- 482
Query: 1785 VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844
EE + S + + V S S ++ D+ L+Q Q
Sbjct: 483 -------------EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQ--Q 527
Query: 1845 LKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE--EVTKMNLLNQQIQ 1902
KE+ A L + Q+ ++ SQ L ++ L S + K+ +LK + E E T+ + Q
Sbjct: 528 AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLAT 587
Query: 1903 EELSRVTKLKE---------TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953
R L+E E+EK E L QL N + + VT AQ +
Sbjct: 588 AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAE 647
Query: 1954 LESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
L +++ L+ CV +E+ + + ++E ++R E + A E + +
Sbjct: 648 LSRKVEELQACVETARQEQHEAQAQVAELELQLRSE--------------QQKATEKERV 693
Query: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
+EK Q QE++ AL+ ++K ++ LE K A A+E +++
Sbjct: 694 AQEKDQ-----------LQEQLQALKESLKV-------TKGSLEEEKRRAADALEEQQRC 735
Query: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE-- 2131
+EL + L + + L + +K L++ + + + + E L R L +A
Sbjct: 736 ISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA 795
Query: 2132 --------EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK-DKEVQQLQENLDS 2182
E+ +KE +E+ + ++E+ E +TL ++ +K Q+LQE
Sbjct: 796 QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE---- 851
Query: 2183 TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ 2242
+ A +S S LQ R + +E + + A+Q +E KE L D L
Sbjct: 852 -AKEKVAGIESHSELQISRQQ--NELAELHANLARALQQVQE----KEVRAQKLADDLST 904
Query: 2243 MSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHS 2302
+ M ++RLE + ++ Q E ++ V + + +++ E+ + S
Sbjct: 905 LQEKMAATSKEVARLE--TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962
Query: 2303 SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD 2362
+Q L +E E + + ++L L +L + + Q+ G QQE ++ + + D
Sbjct: 963 TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG---QQEREVARLTQERGRAQAD 1019
Query: 2363 LQ----ASRELTSRLHEEINMKEQKIISLLSG------KEEAIQVAIAELRQQHDKEIKE 2412
L A EL RL +N + + +L ++E +A+LR +IKE
Sbjct: 1020 LALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE 1079
Query: 2413 LENL----------LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ-------Q 2455
LE L L+++E+E+ +A +T L+ ++ E + Q
Sbjct: 1080 LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
Query: 2456 KAQLDSFVKSMSS---LQNDRDRIVGDYQ-QLEER-----HLSIILEKDQL--------I 2498
+ Q DS +S+ + + +RD + Q QLEE+ H L Q +
Sbjct: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199
Query: 2499 QEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQ 2558
Q+ + ++ K ++ R + NS + L+ E+ LN+ + K+ + K+L +
Sbjct: 1200 QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV----SILNRQVLEKEGESKELKRLV 1255
Query: 2559 LQQNKELENKYAKLEEKLK--ESEEANEDLRRS--FNALQEEKQDLSKEIESLKVSISQL 2614
+ +++ K KLEE+L+ ++E A+ R + +AL+EE Q L +E E +V+ L
Sbjct: 1256 MAESE----KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENL 1311
Query: 2615 TRQVTALQEEGT-----LGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL-EEELVCVQKE 2668
+++T+ E L + + KE+ + L +S+Q ++EL + +C Q +
Sbjct: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ 1371
Query: 2669 AAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKG 2728
A + E + ++EL+ AG +R E A+ + EL + + QK+ + +
Sbjct: 1372 AEQAAAE--KRHREELEQSKQAAGGLRAELLRAQRELGEL----IPLRQKVAEQERTAQQ 1425
Query: 2729 LTAQIQSFGRSMSSLQNS------------------RDHANEELDELKRKYDASLKELAQ 2770
L A+ S+ +S L+ + R ELD+ + KY L +
Sbjct: 1426 LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRA 1485
Query: 2771 LKEQGLLNRERDALLSETAFS-MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLE---- 2825
E L +R+A + M + E + + + Q+ + ++L QLE
Sbjct: 1486 DAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR 1545
Query: 2826 DSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSA-AQPSTSPAEVQSLKKAMS 2884
+ QV+ SK +A + ++ K ++ K ++ AQ S E Q L+ ++
Sbjct: 1546 EQTKQVEELSKKLA-----------DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLN 1594
Query: 2885 SLQNDRDRLLKELKNLQQQY-LQINQEITELHPLKAQLQEYQDKTKAFQIMQ---EELRQ 2940
LQ L + + + Y LQ+ + T K Q QE Q++ ++ + +Q +ELR
Sbjct: 1595 ELQAQ----LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA 1650
Query: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP 3000
E HEL Q ++ E R + Q + + Q++H +R+L T
Sbjct: 1651 EAERLGHELQQAGLKTKEAEQTCRHLTAQ----VRSLEAQVAHADQQLRDLGKFQVATDA 1706
Query: 3001 LKVQYQRQASPETSASPD 3018
LK + + QA P+ S D
Sbjct: 1707 LKSR-EPQAKPQLDLSID 1723
Score = 222 bits (565), Expect = 5e-57
Identities = 349/1640 (21%), Positives = 685/1640 (41%), Gaps = 205/1640 (12%)
Query: 1089 QFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDG------DSVALVK 1142
QFQ ++++ + L D+ + D L+ E++EN+ KL+T DA D +AL+
Sbjct: 213 QFQ--MRRLKKQLADERSNRDELELELAENR----KLLTEK-DAQIAMMQQRIDRLALLN 265
Query: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSR-KAILKKAQEKERHL 1201
E SP LE K E E+L+ K E+LT R LK+ Q+ L
Sbjct: 266 EKQAASP------------LEPK------ELEELRDK-NESLTMRLHETLKQCQD----L 302
Query: 1202 REELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTP 1261
+ E Q N+L E+ + S + L+QLQ + E + +T QE
Sbjct: 303 KTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT--QEWLEKQA 360
Query: 1262 GLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL 1321
LE+ L A L+ C + E LQG ++Q++ L +++ +
Sbjct: 361 QLEKELSAA---------LQDKKCLE-----EKNEILQG--KLSQLEEHLSQLQDNPPQE 404
Query: 1322 ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI 1381
+ +V +L +E L + +E L+T + E + + E + Q+
Sbjct: 405 KGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQL 464
Query: 1382 AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEI---IEQEDLIKA 1438
+ L + +LQ + L + + E+ +L+ + A+LT T + I+Q+D A
Sbjct: 465 SSL--ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA 522
Query: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1498
L+ QAKE Q +L + Q+ E+ + R + + +L ++L +++ LKE
Sbjct: 523 ---GLKQQAKEK-------QAQLAQTLQQQEQASQGLRHQVE---QLSSSLKQKEQQLKE 569
Query: 1499 NKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRS 1558
QE T + + LA + A +E+D L +L L++E+ + + +
Sbjct: 570 VAEKQE------ATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Query: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK--EYE 1616
L Q + + +S + ++ +K +L +++E L++ T QE+H+ + E E
Sbjct: 624 L---QVANEARDSAQTSVTQAQREKAELSRKVEELQA---CVETARQEQHEAQAQVAELE 677
Query: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME---- 1672
+ L+S + + E ER+ + ++++ Q L L+ T+ + +E +++ +A +E +
Sbjct: 678 LQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS 737
Query: 1673 EMKEKMRKFAKSKQQKILELEEEND------------------------RLRAEVHPAGD 1708
E+K + R + +++ ELEEE R AE A
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797
Query: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQ----SLMSEKDSLSEEVQDLKHQIE 1764
TA+ E L+ A+ +E E + E FQ +L E + +E+Q+ K ++
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
Query: 1765 G-------NVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPS 1817
G +S+Q N E E H N ++ + + D LS + S
Sbjct: 858 GIESHSELQISRQQN-ELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEV 916
Query: 1818 AK--------------SANPAVSKDFSSHDEINNYL--QQIDQLKERIAGLEEEKQKNKE 1861
A+ ++ V + + D +L QQ Q A L+ +++ ++
Sbjct: 917 ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQ 976
Query: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDD 1921
LE + L+ + E + EV ++ + Q +L+ L++ A E
Sbjct: 977 MGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLA----LEKAARAE--- 1029
Query: 1922 LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTK 1981
LE RL N L E + + A + E + E+ L+ + +E ++L + +
Sbjct: 1030 LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQ 1089
Query: 1982 VESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT 2041
++ ++ K+ E G+ + + L+ + EV +L++ C + QE+ +LER+
Sbjct: 1090 LKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS 1149
Query: 2042 VKALEFVQTESQKDLEITK---ENLAQAVEHRK----KAQAELASFKVLLDDTQSEAARV 2094
++A + E LE + E AQ + H + AQ ELA+F+ + D
Sbjct: 1150 LEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEW 1209
Query: 2095 LADNLKLKKELQSNKESVKSQMKQKDEDLERRL--EQAEEKHLK--------EKKNMQEK 2144
A + ++E + K S+ S ++++ L R++ ++ E K LK + + ++E+
Sbjct: 1210 KAQVARGRQEAE-RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1268
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
L L+ E E L +EVQ L+E + + ++S + + +
Sbjct: 1269 LRLLQAETASNSARAAERSSALR---EEVQSLREEAEKQRVASENLRQELTSQAERAEEL 1325
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
E K W+ KF Q+ ++L+ + L +L K +L+ ++
Sbjct: 1326 GQELKAWQEKFFQKEQAL-STLQLEHTSTQALVSELL-------PAKHLCQQLQAEQAAA 1377
Query: 2265 ESKAQTEVQLQQKVCDTLQGE---NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321
E + + E++ ++ L+ E + L +L R + +L +E S +QL
Sbjct: 1378 EKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQL 1437
Query: 2322 TDLSNSLEKCKEQK---GNLEGIIRQ-QEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377
+ L + E+ G + RQ E ++ ++ Y Q ++A E +
Sbjct: 1438 SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQRE 1497
Query: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437
+ + +++ K E +V + E RQ+ +E + L +Q E+ + E+ K+ +
Sbjct: 1498 AQSTARELEVMTAKYEGAKVKVLEERQRFQ---EERQKLTAQVEQLEVFQREQTKQVEEL 1554
Query: 2438 TNQLMETLKTIKKENIQQK---AQLDSFVKSMSSLQNDRDRIVGDYQQLEE--RHLSIIL 2492
+ +L ++ + K + + K AQ + LQ + + Q E+ H + +
Sbjct: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614
Query: 2493 EKDQLIQEA-AAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQ 2551
EK + +A +N +L+E++R L + L EN +L AE + +L Q +K +
Sbjct: 1615 EKAKTHYDAKKQQNQELQEQLRSL----EQLQKENKELRAEAERLGHELQQA-GLKTKEA 1669
Query: 2552 KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611
+Q Q + LE + A +++L++ + + + K L I+SL +S
Sbjct: 1670 EQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSC 1729
Query: 2612 SQ-----LTRQVTALQEEGT 2626
+ +T ++ Q +GT
Sbjct: 1730 EEGTPLSITSKLPRTQPDGT 1749
Score = 216 bits (551), Expect = 2e-55
Identities = 394/1845 (21%), Positives = 750/1845 (40%), Gaps = 227/1845 (12%)
Query: 615 LEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSA 674
LE+ Q P+ S+ P +E + HQ++ EI + ++ ++ G+ LS
Sbjct: 147 LENFLQKAPVPSTCSSTFP---EELSPPSHQAK--REIRFLE--LQKVASSSSGNNFLSG 199
Query: 675 VP-----DIGQCHQDELERLKSQILELELNFHKAQ-EIYE--KNLDEKAKEISNLNQLIE 726
P DI Q Q ++ RLK Q+ + N + + E+ E K L EK +I+ + Q I+
Sbjct: 200 SPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRID 259
Query: 727 EFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYES 786
L+E++ + KEL ELR + + L M L
Sbjct: 260 RL-----------ALLNEKQAASPLEPKELE---ELRDKNESLTMRL------------- 292
Query: 787 QTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE 846
H+ L +Q L E D KI L E D+ + E ++ ++ LQ L E
Sbjct: 293 ---HETL--KQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEE 347
Query: 847 VLEGAERVRHISSKVEELS-QALSQKELEITKMDQLLLEKKRDV---------ETLQQTI 896
H + E L QA +KEL D+ LE+K ++ E L Q
Sbjct: 348 ---------HSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQV------- 949
+ Q+ E+ + + + L +E +L L+ ++ +L ++ ++
Sbjct: 399 DNPPQEKGEVLGDVLQ-LETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHF 457
Query: 950 -EEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQR 1008
EE ++SS + +S Q +KEEL+ + L + L +Q+
Sbjct: 458 EEEKQQLSSLITDLQSSISNLSQ-AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQ 516
Query: 1009 VSRLEEELANLKDESK-KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS 1067
++ELA LK ++K K+ L++T + + E+ + + + ++S ++ E LK+
Sbjct: 517 Q---DQELAGLKQQAKEKQAQLAQTLQQQ-EQASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
Query: 1068 EKEVELQHIRKDL----EEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQ 1123
++E Q + L EE+ A+ + A +KQ+ ++K ++++LQ ++
Sbjct: 573 KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 1124 KLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA 1183
TS T A A + V C ++ + E + ++ LE QL+ + Q+A
Sbjct: 633 SAQTSVTQAQR--EKAELSRKVEELQACVETARQEQHEAQAQVAELEL---QLRSEQQKA 687
Query: 1184 LTSRKAILKK--AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241
+ +K QE+ + L+E LK K + + + +E + + +L+ + R
Sbjct: 688 TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRC---ISELKAETR 744
Query: 1242 ESIDG-KLPSTDQQESCSSTPGLEEPLFKATEQHHTQP-VLESNLCPDWPS-HSEDASAL 1298
++ K + +E + GLE L + E H + VL L + H+ ++
Sbjct: 745 SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE 804
Query: 1299 QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQ-LQEQINK-QGLEIESL 1356
Q VA + + ++ + E+ + L ++ E+ Q LQE K G+E S
Sbjct: 805 QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSE 864
Query: 1357 KTVSHE----AEVHAE---SLQQKLESSQLQIAGLEHLRELQPKLD-------ELQKLIS 1402
+S + AE+HA +LQQ E + L LQ K+ L+ L+
Sbjct: 865 LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD-----ERIKQL 1457
K E S +L ++ A Q E +E++ + TQ +QA E + +++L
Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
Query: 1458 QVELCEMK-QKPEEIGEESRAKQQIQR---KLQAALISRKEALKE-NKSLQEELSLARGT 1512
+ L E + Q+ EE G++ R ++ + + QA L K A E LQ L+ R
Sbjct: 985 RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044
Query: 1513 IERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL---ITEMDRSLLENQSLSSSC 1569
L ++LA ++ +++E + G A +E ++L + ++ L + + +S
Sbjct: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASG 1104
Query: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA 1629
+ G TE ++ + + S + + QE+ L++ E S +
Sbjct: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSAL 1164
Query: 1630 ERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE---AEQEMEEMKEKMRKFAKSKQ 1686
E +Q +E QE L S + ++Q+ AE E + + R+ A+ K
Sbjct: 1165 ETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKN 1224
Query: 1687 QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLM 1746
I LEEE L +V +KE +++ + ++ ER+++ +
Sbjct: 1225 SLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 1747 SEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE----QDS 1802
+L EEVQ L+ + E NL ++ +Q EE Q + E+ + +
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLR--QELTSQAERAEELGQELKAWQEKFFQKEQA 1342
Query: 1803 LSM------STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK 1856
LS ST+ SE +P+ ++ ++ + ++++Q K+ GL E
Sbjct: 1343 LSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE---KRHREELEQSKQAAGGLRAE- 1398
Query: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916
L + + GEL L+++V + QQ++ E + +
Sbjct: 1399 -----------------LLRAQRELGELIPLRQKVAEQERTAQQLRAE--------KASY 1433
Query: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV 1976
E+ + ++ LAE N +G A + + LE E L++ +++ V
Sbjct: 1434 AEQLSMLKKAHGLLAEENRGLGER------ANLGRQFLEVE----------LDQAREKYV 1477
Query: 1977 KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKIS 2036
+E V ++ E + AQ S A+EL+ + + + ++ ++ R+QE+
Sbjct: 1478 QELAAVRADAETRLAEVQREAQ------STARELEVMTAKYEGAKVKVLEERQRFQEERQ 1531
Query: 2037 ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA 2096
L V+ LE Q E K +E + LA + + K Q +L + + ++Q EA R+ A
Sbjct: 1532 KLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQA 1591
Query: 2097 DNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156
+L+ +L SQ +Q E + ++E+A+ H KK ++L R L+
Sbjct: 1592 QLNELQAQL--------SQKEQAAEHYKLQMEKAKT-HYDAKKQQNQELQEQLRSLEQLQ 1642
Query: 2157 ETIGEIQVTLNKKDKEVQQL---QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER 2213
+ E++ + E+QQ + + T L A +S+ + D+ + + K++
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQV 1702
Query: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQ 2273
+DA++S+E + + Q+ + ++ L ++ I +T+
Sbjct: 1703 A-TDALKSREPQAK-------------PQLDLSIDSLDLSCEE-GTPLSITSKLPRTQPD 1747
Query: 2274 LQQKVCDTLQGENKELLSQLEETRHLYHSS--QNELAKLESELKSLKDQLTDLSNSLEKC 2331
+ ++ L ++E LY + A LES L SL D D
Sbjct: 1748 GTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSA 1807
Query: 2332 KEQKGNLEGIIRQQEADIQ-----NSKFSYEQLETDLQASRELTS 2371
+ + + I ++ D++ NS F + QAS TS
Sbjct: 1808 RRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATS 1852
Score = 211 bits (538), Expect = 7e-54
Identities = 316/1534 (20%), Positives = 651/1534 (42%), Gaps = 165/1534 (10%)
Query: 1389 ELQPKLDELQKLISKKEEDVSYLSGQ------LSEKEAALTKIQTEIIEQEDLIKALHTQ 1442
EL+ +L E +KL+++K+ ++ + + L+EK+AA E+ E D ++L +
Sbjct: 232 ELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMR 291
Query: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSL 1502
L K+ + L+ E +M +K ++ EE+ R+ + L ++AL E L
Sbjct: 292 LHETLKQ----CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE---L 344
Query: 1503 QEELSLARGTIERLTKSLADVESQVSA--QNK----EKDTVL-GRLALLQEERDKLITEM 1555
EE S A T E L K A +E ++SA Q+K EK+ +L G+L+ L+E +L
Sbjct: 345 TEEHSKA--TQEWLEKQ-AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNP 401
Query: 1556 DRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK-------IAESTEWQEKH 1608
+ E E+LK L + +L +E L++ + +AE ++E+
Sbjct: 402 PQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEK 461
Query: 1609 KELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAE 1668
++L L S N+S E ++ +A L ++ S + +Q+ +
Sbjct: 462 QQLSSLITDLQSSISNLSQAKEELEQASQA---HGARLTAQVASLTSELTTLNATIQQQD 518
Query: 1669 QEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL 1728
QE+ +K++ ++ Q + + E+ + LR +V + K+ + L +
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
Query: 1729 ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS--KQANLEATEKHDN-QTNV 1785
+ + T +++ ++ + E+D+ ++++ L+ + + +Q A E D+ QT+V
Sbjct: 579 QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
Query: 1786 TEEGTQS--IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID 1843
T+ + + + EE + + R E+ + + E Q+ D
Sbjct: 639 TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD 698
Query: 1844 QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQE 1903
QL+E++ L+E + K +LE EK + + + L+ E + +++ ++
Sbjct: 699 QLQEQLQALKESLKVTKG---SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
Query: 1904 EL-----------SRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
EL +R+ +L E + E + L L +A + + Q V + E
Sbjct: 756 ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE 815
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK--EPGNKSHAKEL 2010
E + + + +E+ L +E K E++ E EK+ G + E EL
Sbjct: 816 RYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ-EAKEKVAGIESHSELQISRQQNEL 874
Query: 2011 QEL----------LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITK 2060
EL ++EK+ ++L D QEK++A + V LE + ++ + E
Sbjct: 875 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETAS 934
Query: 2061 ENLAQAVEHRKKAQAELASFKV--LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
L + Q E + TQ+ + + ++ EL+ + ++ Q
Sbjct: 935 RELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ 994
Query: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2178
+ E ER ++ E L +++ + AL EK E +Q LN++ E LQE
Sbjct: 995 QQE--ERGQQEREVARLTQERGRAQADLAL--EKAARAELEMRLQNALNEQRVEFATLQE 1050
Query: 2179 NLDSTVTQLAAFTKSMSSLQD---DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV 2235
L +T+ + ++ L+ + + ++E ++ ++ + + KE+E S
Sbjct: 1051 ALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110
Query: 2236 LKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT-EVQLQQKVCDTLQGEN--KELLSQ 2292
+ +E L+ +S+LE Q + +A + E L+ + + ++ + L Q
Sbjct: 1111 AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170
Query: 2293 LEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
LEE SQ+ LA + EL + + ++ D S + ++ K Q +QEA+ +NS
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR-----GRQEAERKNS 1225
Query: 2353 KFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE 2412
L S L EE+++ ++++ +E ++ +AE + ++++E
Sbjct: 1226 ----------------LISSLEEEVSILNRQVLEKEGESKELKRLVMAE--SEKSQKLEE 1267
Query: 2413 LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472
LL E N + +A ++++ L E ++++++E +Q+ ++ + ++S
Sbjct: 1268 RLRLLQAETASN------SARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
Query: 2473 RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK---LKEEIRGLRSHMDDLNSENAKL 2529
+ + + + +E+ +K+Q + E+ L E+ + L +E A
Sbjct: 1322 AEELGQELKAWQEK----FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAA 1377
Query: 2530 DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS 2589
+ ++RE+L Q + +LL Q +EL + L +K+ E E + LR
Sbjct: 1378 EK---RHREELEQSKQAAGGLRAELLRAQ----REL-GELIPLRQKVAEQERTAQQLRA- 1428
Query: 2590 FNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKV---KEEEVHRLSA 2646
EK ++++ LK + L + L E LG ++++ +E+ V L+A
Sbjct: 1429 ------EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIED---KLKKELKHLHHDAGIMRNETETAE- 2702
+ + ++ R+AE++ E +E + E K+ +E + + + + E E
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 2703 ------ERVAELARDLVE-------MEQKLLMVT-------KENKGLTAQIQSFGRSMSS 2742
++V EL++ L + +QKL V +E + L AQ+ +S
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602
Query: 2743 LQNSRDHANEELDELKRKYDASLKELAQLKEQ----GLLNRERDALLSETAFSMNSTEEN 2798
+ + +H ++++ K YDA ++ +L+EQ L +E L +E + ++
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662
Query: 2799 SLSHLE------KLNQQLLSKDEQLLHLSSQLED 2826
L E L Q+ S + Q+ H QL D
Sbjct: 1663 GLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRD 1696
Score = 207 bits (526), Expect = 2e-52
Identities = 361/1674 (21%), Positives = 692/1674 (41%), Gaps = 252/1674 (15%)
Query: 66 DIIRQKDVQLQQKDEALQEERKAADN------KIKKLKLHAKAKLTSLNKYIEEMKA--Q 117
DI++ Q+++ + L +ER D + +KL A++ + + I+ + +
Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
Query: 118 GGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQ 177
P EP+ E+L ++S T M + + + Q+ + S + ++ Q +E+
Sbjct: 267 KQAASPLEPKELEELRDKNESLT---MRLHETLKQCQDLKTEKSQMDRKINQL-SEENGD 322
Query: 178 SSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE-DE 236
S ++ EF QQLQ+ ++ ++ +Q E+ AQ + +E A + + L E +E
Sbjct: 323 LSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ-LEKELSAALQDKKCLEEKNE 381
Query: 237 LLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQL 296
+LQ +++++ L LQ + + ++G ++ L+QE N L ++
Sbjct: 382 ILQ-----GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARV 436
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS--FHNLQEEMHHLLEQFEQAGQ 354
+ +E E ++E+K+L E+ E +++LS +LQ + +L Q
Sbjct: 437 EMLETERG---------QQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL-------SQ 480
Query: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414
A+ ELE A + A++ TS + +L T Q+ LK Q E+
Sbjct: 481 AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ-------AKEKQA 533
Query: 415 QSAQTIQQLEDQ---LQQKSKEISQFLNRLPLQQHETA-SQTSFPDVYNEGTQAVTEENI 470
Q AQT+QQ E L+ + +++S L + Q E A Q + + + EE
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 471 ASLQ------KRVVELENEKGALLLSSIELEELKAENE-KLSSQITLLEAQNRTGEADRE 523
ASL+ K++ LE EK A L I ++L+ NE + S+Q ++ +AQ E R+
Sbjct: 594 ASLRERDAALKQLEALEKEKAAKL--EILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651
Query: 524 VSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
V E+ Q +E ++H EAQ ++A L+LQL+ +
Sbjct: 652 VEEL-----------------QACVETARQEQH-----------EAQAQVAELELQLRSE 683
Query: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ-AST 642
+ + + E + Q++ + E +KV L + + A+E++Q +
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKESLKV------TKGSLEEEKRRAADALEEQQRCIS 737
Query: 643 EHQSRTSEEISLNDAGVELKSTKQDGDKSLSA-VPDIGQCHQDELERLKSQILELELNFH 701
E ++ T + + + ++ G K L A + +G+ HQ E E L+ ++ E
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEA----M 793
Query: 702 KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAF----TALSEERDQLLSQVKELS 757
AQ E ++ KE++ + E+ ++ + F L EE ++ +++E
Sbjct: 794 AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
Query: 758 ------------MVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHSLSIE 804
++ + ++ +L NLA A +Q + + +Q D+L T Q +
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQ---EKMA 910
Query: 805 AKSKDV-KIEVLQNELDDVQLQFS--------------------EQSTLIRSLQSQLQNK 843
A SK+V ++E L + + Q S +Q S Q+ LQ
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAM 970
Query: 844 ESEVLEGAERVRHISSKVEE----LSQALSQKELEITKMDQ--------LLLEKKRDVE- 890
E E + + + + + E + Q+E E+ ++ Q L LEK E
Sbjct: 971 EREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAEL 1030
Query: 891 --TLQQTIEEKDQQVT----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEA 944
LQ + E+ + ++ ++TEK + E G+E +KE L ++
Sbjct: 1031 EMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQL 1090
Query: 945 KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKE 1004
K++ +++ E +SG + + ++ K E + +K++ QA + R
Sbjct: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSL 1150
Query: 1005 LLQRVSRLE-----EELANLKDESKKEIPLSETERGEVE----------EDKENKEYSEK 1049
+R SR E E L +E +E+ S++ + +D E K
Sbjct: 1151 EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK 1210
Query: 1050 CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQID 1109
++ ++ IS E E+ + + + EK ++ + LV ++ Q ++
Sbjct: 1211 AQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
Query: 1110 LLQAEISENQA-------IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162
LLQAE + N A +++ + S + ++ VA + + T +E EL
Sbjct: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVA----SENLRQELTSQAER-AEEL 1325
Query: 1163 EEKILALEK---EKEQLQKKLQEALTSRKAIL---------------KKAQEKERHLREE 1204
+++ A ++ +KEQ LQ TS +A++ ++A ++RH REE
Sbjct: 1326 GQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH-REE 1384
Query: 1205 LKQQKD-------DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESC 1257
L+Q K + R Q + E + + +Q R Q Q+R K +Q
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ-QLRAE---KASYAEQLSML 1440
Query: 1258 SSTPGL--EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
GL EE + + LE L + ++ +A++ + Q +E +
Sbjct: 1441 KKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQ-REAQ 1499
Query: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL- 1374
+ ELE+ + K EE + QE+ K ++E L+ E E L +KL
Sbjct: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
Query: 1375 ESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434
+S Q + L+ +Q + E Q+ + + ++ L QLS+KE A
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA------------- 1606
Query: 1435 LIKALHTQLEMQ-AKEHDERIKQLQVELCEMKQKPEEIGEESR----AKQQIQRKLQAAL 1489
A H +L+M+ AK H + KQ EL E + E++ +E++ +++ +LQ A
Sbjct: 1607 ---AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAG 1663
Query: 1490 ISRKEALKENKSLQEELSLARGTIERLTKSLADV-ESQVSAQNKEKDTVLGRLALLQEER 1548
+ KEA + + L ++ + + L D+ + QV+ D + R + +
Sbjct: 1664 LKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVAT-----DALKSREPQAKPQL 1718
Query: 1549 DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE-------KLVKEIESLKS 1595
D I +D S E LS + + + +G + E +L ++ESL+S
Sbjct: 1719 DLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLES 1772
Score = 193 bits (490), Expect = 3e-48
Identities = 327/1659 (19%), Positives = 681/1659 (41%), Gaps = 185/1659 (11%)
Query: 1505 ELSLARGTIERLTKSLADVES-----QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL 1559
EL LA+ T+ L S +S Q + + + V+ + L E+ L +++ +
Sbjct: 92 ELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLE-NF 150
Query: 1560 LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE--KHKELQKEYEI 1617
L+ + S+C S E L+ + +EI L+ K+A S+ +I
Sbjct: 151 LQKAPVPSTCSST--FPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDI 208
Query: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA--EQEMEEMK 1675
L + + R++ + R + EL +L E K TEK Q A +Q ++ +
Sbjct: 209 L----QTPQFQMRRLKKQLADERSNRDEL--ELELAENRKLLTEKDAQIAMMQQRIDRLA 262
Query: 1676 EKMRKFAKS--KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733
K A S + +++ EL ++N+ L +H +T K+C + L + + M ++ ++
Sbjct: 263 LLNEKQAASPLEPKELEELRDKNESLTMRLH---ETLKQCQD-LKTEKSQMDRKINQLSE 318
Query: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
E LS K + S L + + +L E + + Q LE + + + + + + +
Sbjct: 319 ENGDLSFKLREFASHLQQLQDALNELTE--EHSKATQEWLEKQAQLEKELSAALQDKKCL 376
Query: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
EE++ + E + + NP K E+ + Q++ LK+ A L
Sbjct: 377 ----EEKNEILQGKLSQLEEHLSQLQD-NPPQEKG-----EVLGDVLQLETLKQEAATLA 426
Query: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKE 1913
+ + + LE E+ +++ + G +EE +++ L +Q +S +++ KE
Sbjct: 427 ANNTQLQARVEMLETERGQQEAKLLAERGHF---EEEKQQLSSLITDLQSSISNLSQAKE 483
Query: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
E+ RL Q+A L + +A I+ + + E+ LK+ E + +
Sbjct: 484 ELEQASQAHGARLTAQVASLTSEL-----TTLNATIQQQ--DQELAGLKQQAKEKQAQLA 536
Query: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE-VKQLQKDCIRYQ 2032
Q ++++ + +R + +E++ + K+ + KE+ E + +Q+ +QL +
Sbjct: 537 QTLQQQEQASQGLRHQ-VEQLSSSLKQ--KEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 2033 EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA 2092
+ + +K LE ++ E LEI ++ L A E R AQ + ++A
Sbjct: 594 ASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV-----------TQAQ 642
Query: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDE---DLERRLEQAEEKHLKEKKNMQEKLDALR 2149
R A+ + +ELQ+ E+ + + + +LE +L ++K ++++ QEK D L+
Sbjct: 643 REKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK-DQLQ 701
Query: 2150 REKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAK 2209
+ L+E++ + +L ++ + E +++L A T+S+ Q R+R E +
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE-QHKRERKELEEE 760
Query: 2210 KWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQ 2269
+ RK +A + E E VL+ +L + + +L + W + +
Sbjct: 761 RAGRKGLEARLQQLGEAHQAETE--VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE 818
Query: 2270 TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLE 2329
Q + + Q + L + E+ R ++ ++A +ES + +S
Sbjct: 819 DSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSE------LQISRQQN 872
Query: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389
+ E NL ++Q +Q + ++L DL +E + +E+ E +
Sbjct: 873 ELAELHANLARALQQ----VQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE 928
Query: 2390 GKEEAIQVAIAELRQQHDKEIKELENLLSQEE-EENIVLEEENKKAVDKTNQLMETLKTI 2448
+E A + + E + D++ + LE ++ L+ ++A N+L +
Sbjct: 929 QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
Query: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508
+ QQ+ + + ++ L +R R D + + + + E E L
Sbjct: 989 MESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATL 1048
Query: 2509 KEEIRGLRSHMDDLNSENAKL---DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKEL 2565
+E + + + + E AKL +A I+ E+L Q + KQL E ++ KE
Sbjct: 1049 QEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV-------KQLKEQLAKKEKEH 1101
Query: 2566 ENKYAKLEEKLKESEEAN---EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ 2622
+ E +E E LR + L+++ Q ++ +SL+ S+ + + +
Sbjct: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLE--AERASRAE 1159
Query: 2623 EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK 2682
+ L QL+ K +E+ + +S+Q+ +A ++ + + ED+ K
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV--------QDHSKAEDEWKA 1211
Query: 2683 ELKHLHHDAGIMRNETETAEERVAELARDLVEME------QKLLMVTKENKGLTAQ---- 2732
++ +A + + EE V+ L R ++E E ++L+M E +
Sbjct: 1212 QVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL 1271
Query: 2733 IQSFGRSMSSLQNSRDHA-NEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
+Q+ S S+ R A EE+ L+ + + L+++ ER L + +
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKA 1331
Query: 2792 MNST---EENSLSHLE---KLNQQLLSKDEQLLHLSSQLEDSY--------NQVQSFSKA 2837
+E +LS L+ Q L+S+ HL QL+ +++ +A
Sbjct: 1332 WQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQA 1391
Query: 2838 MASLQNERDHLWNEL-------EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR 2890
L+ E EL +K + E Q+ A+ ++ ++ LKKA L +
Sbjct: 1392 AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE- 1450
Query: 2891 DRLLKELKNLQQQYLQINQE------ITELHPLKAQLQ--------EYQDKTKAFQIM-- 2934
+R L E NL +Q+L++ + + EL ++A + E Q + ++M
Sbjct: 1451 NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510
Query: 2935 -----QEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIR 2989
+ ++ +E +Q E +L + E+ +R +Q ++ L +
Sbjct: 1511 KYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR--------------EQTKQVEELSK 1556
Query: 2990 ELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKE---- 3045
+L S Q KVQ Q+ + + E + L+ QLN+ ++ QKE
Sbjct: 1557 KLADSD---QASKVQQQKLKAVQAQGGESQQ-----EAQRLQAQLNELQAQLSQKEQAAE 1608
Query: 3046 ---LRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQ 3081
L++++ +++ ++ L QL Q +EN++
Sbjct: 1609 HYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE 1647
Score = 189 bits (481), Expect = 3e-47
Identities = 308/1570 (19%), Positives = 632/1570 (40%), Gaps = 234/1570 (14%)
Query: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKM---RKFAKSKQQKILELEEENDRLRA--EVH 1704
L++ + + +KQL + +E++ ++ RK K +I +++ DRL E
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQ 268
Query: 1705 PAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
A + +E L N S+ L + + L + + + + LSEE DL ++
Sbjct: 269 AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLR 328
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
S L+ D +TEE +++ E+Q L A
Sbjct: 329 EFASHLQQLQ-----DALNELTEEHSKATQEWLEKQAQLEKELS---------------A 368
Query: 1825 VSKDFSSHDEINNYLQ-QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883
+D +E N LQ ++ QL+E ++ L++ + EK +L + +
Sbjct: 369 ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQ----------EKGEVLGDVL----Q 414
Query: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943
L+ L++E + N Q+Q + E E E+ E +L+ +
Sbjct: 415 LETLKQEAATLAANNTQLQARV-------EMLETERGQQEAKLLAERGHFEEEKQQLSSL 467
Query: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQ----QLVKEKTKVESEIRKEYLEKIQGAQK 1999
+TD L+S + NL + ELE+ Q +L + + SE+ Q Q+
Sbjct: 468 ITD-------LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520
Query: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISA-LERTVKALEFVQTESQKDLEI 2058
G K AKE Q L + Q+ +Q + E++S+ L++ + L+ V + + +
Sbjct: 521 LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD 580
Query: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA---RVLADNLKLKKELQSNKESVKSQ 2115
+ LA A E R+ + E + L+ + E A +L L++ E + + ++ +Q
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQ 640
Query: 2116 MKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN---KKDKE 2172
+++ +L R++E+ +Q ++ R+E+ + + E+++ L +K E
Sbjct: 641 AQREKAELSRKVEE-----------LQACVETARQEQHEAQAQVAELELQLRSEQQKATE 689
Query: 2173 VQQLQENLDSTVTQLAAFTKSMS----SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
+++ + D QL A +S+ SL++++ R D ++ +R S+ L
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISE----------L 739
Query: 2229 KEDNCSVLKDQLRQMSIHMEELKINISRLEHD-KQIWES-KAQTEVQLQQKVCD------ 2280
K + S+++ R+ +EE + LE +Q+ E+ +A+TEV L++++ +
Sbjct: 740 KAETRSLVEQHKRERK-ELEEERAGRKGLEARLQQLGEAHQAETEV-LRRELAEAMAAQH 797
Query: 2281 TLQGENKELLSQLEETRHLYHSSQNELAK----LESELKSLKDQLTDLSNSLEKCKEQKG 2336
T + E ++L+ ++ R Y SQ E A+ + +L +LK++ L++ KE+
Sbjct: 798 TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA 857
Query: 2337 NLEG-----IIRQQEA-------------DIQNSKFSYEQLETDLQASRELTSRLHEEIN 2378
+E I RQQ +Q + ++L DL +E + +E+
Sbjct: 858 GIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVA 917
Query: 2379 MKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE-EENIVLEEENKKAVDK 2437
E + +E A + + E + D++ + LE ++ L+ ++A
Sbjct: 918 RLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
Query: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497
N+L + + QQ+ + + ++ L +R R D + + +
Sbjct: 978 GNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA 1037
Query: 2498 IQEAAAENNKLKEEIRGLRSHMDDLNSENAKL---DAELIQYREDLNQVITIKDSQQKQL 2554
+ E E L+E + + + + E AKL +A I+ E+L Q + KQL
Sbjct: 1038 LNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV-------KQL 1090
Query: 2555 LEVQLQQNKELENKYAKLEEKLKESEEAN---EDLRRSFNALQEEKQDLSKEIESLKVSI 2611
E ++ KE + E +E E LR + L+++ Q ++ +SL+ S+
Sbjct: 1091 KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSL 1150
Query: 2612 SQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAK 2671
+ + + + L QL+ K +E+ + +S+Q+ +A ++ +
Sbjct: 1151 E--AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV--------Q 1200
Query: 2672 KVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTA 2731
+ ED+ K ++ +A + + EE V+ L R ++E E +
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE------------- 1247
Query: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
+ + L + +++L+E R A + ER + L E S
Sbjct: 1248 -----SKELKRLVMAESEKSQKLEERLRLLQA------ETASNSARAAERSSALREEVQS 1296
Query: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851
+ E E L Q+L S+ E+ L +L+ + +A+++LQ E
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQAL 1356
Query: 2852 LEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEI 2911
+ + ++ Q+ A+ + + K+ L+ + + L+ + L+ +E+
Sbjct: 1357 VSELLPAKHLCQQLQAEQAAAE------KRHREELEQSK----QAAGGLRAELLRAQREL 1406
Query: 2912 TELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYL 2971
EL PL+ ++ E Q++T ++LR E S+ +L L+ R + E+
Sbjct: 1407 GELIPLRQKVAE-QERTA------QQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459
Query: 2972 MAISDKDQQLSHL-QNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELL 3030
+ + +L + ++EL + + + + QR+A Q+ E E++
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREA-----------QSTARELEVM 1508
Query: 3031 RTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHC 3090
+ + ++ ++ R Q EE+ L+ Q+ RE
Sbjct: 1509 TAKYEGAKVKVLEERQRFQ----------EERQKLTAQVEQLEVFQREQT---------- 1548
Query: 3091 AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEV 3150
KQV+EL + D A Q+K L+ Q E+QQ+ + ++
Sbjct: 1549 ----KQVEELSKKLADSDQASKVQQQK-----------LKAVQAQGGESQQEAQRLQAQL 1593
Query: 3151 NELRKLLEEE 3160
NEL+ L ++
Sbjct: 1594 NELQAQLSQK 1603
Score = 167 bits (424), Expect = 1e-40
Identities = 256/1292 (19%), Positives = 538/1292 (41%), Gaps = 144/1292 (11%)
Query: 51 QERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY 110
+E L+ +L+ I L Q E L++ +A ++ ++LT+LN
Sbjct: 458 EEEKQQLSSLITDLQSSISN----LSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 111 IEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA 170
I++ Q + + Q++E+ ++ ++ ++E + ++H++ E+L S+L+ + Q
Sbjct: 514 IQQ---QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQV---EQLSSSLKQKEQQL 567
Query: 171 QAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA---EQAAQQVVREKDARFE 227
+ Q +T + + +E+E + A L Q +A E+AA+ + ++ +
Sbjct: 568 KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
Query: 228 TQVRLHEDELLQLVTQADVE-TEMQQKLRVLQRKLEE-HEESLVGRAQVVDLL------Q 279
+ R D VTQA E E+ +K+ LQ +E +E +AQV +L Q
Sbjct: 628 NEAR---DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQ 684
Query: 280 QELTAAE---QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336
Q+ T E Q L +QLQ ++ + ++E E+ + LE+ + ++E K
Sbjct: 685 QKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETR 744
Query: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACD 396
+L E+ ++ E+ + LE+R L + H+AE E + +S C+
Sbjct: 745 SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE 804
Query: 397 ALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD 456
L + + + + + AQ ++QL +E + L + + A S +
Sbjct: 805 QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSE 864
Query: 457 VYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNR 516
+ Q E A+L + + +++ ++ + +L L+ + S ++ LE R
Sbjct: 865 LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 517 TGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFL 576
+E + +V + E ++ F L + E ++ E+ L
Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
Query: 577 K---LQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLP 633
+ ++ QG++ EE + + + Q G A + + E+++
Sbjct: 985 RAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL----------------EKAARA 1028
Query: 634 AVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI 693
+E + ++ R E +L +A + K+ D+ L+ + + ELE L+ +
Sbjct: 1029 ELEMRLQNALNEQRV-EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTV 1087
Query: 694 LELELNFHKAQEIYEK-----------------NLDEKAKEISNLNQLIEEFKKNADNNS 736
+L+ K ++ + L+ E+S L Q ++ ++ AD+
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE 1147
Query: 737 SAFTALSEERDQLLSQVKELSMVTELRAQ-VKQLEMNLAEAERQRRL------------- 782
+ A R + S ++ L E +AQ + + LA A+R+
Sbjct: 1148 RSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAED 1207
Query: 783 DYESQTAHDNLLTEQIHSL--SIEAKSKDVKIEVLQNELDDVQLQ--FSEQSTLIRSLQS 838
++++Q A E+ +SL S+E + + +VL+ E + +L+ +S + L+
Sbjct: 1208 EWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEE 1267
Query: 839 QLQNKESEVLEGAERVRHISSKVEELSQALSQK-----------ELEITKMDQLLLEKKR 887
+L+ ++E + R SS + E Q+L ++ E+T + E +
Sbjct: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQ 1327
Query: 888 DVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNL-LSRAEEAKK 946
+++ Q+ +K+Q ++ + T ++E + K L +QL + AE+ +
Sbjct: 1328 ELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL-----LPAKHLCQQLQAEQAAAEKRHR 1382
Query: 947 EQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELL 1006
E++E+ + + GL+ ++ EL L +K EQ +R Q +
Sbjct: 1383 EELEQSKQAAGGLRAELLR-------AQRELGELIPLRQKVAEQ-ERTAQQLRAEKASYA 1434
Query: 1007 QRVSRLEEELANLKDESKKEIPLSETERG--EVEEDKENKEYSEKCVT------SKCQEI 1058
+++S L++ L +E++ + R EVE D+ ++Y ++ ++ E+
Sbjct: 1435 EQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV 1494
Query: 1059 EIYLKQTISEKEVELQHIR----KDLEEKLAAEEQFQALVKQMNQT---LQDKTNQIDLL 1111
+ + T E EV K LEE+ +E+ Q L Q+ Q +++T Q++ L
Sbjct: 1495 QREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554
Query: 1112 QAEI--SENQAIIQKLITSNTDASDGDS-------VALVKETVVISPPCTGSSEHWKPEL 1162
++ S+ + +Q+ A G+S A + E ++EH+K ++
Sbjct: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614
Query: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222
E+ + +K+Q Q +LQE L S L++ Q++ + LR E + RL + +
Sbjct: 1615 EKAKTHYDAKKQQNQ-ELQEQLRS----LEQLQKENKELRAEAE-------RLGHELQQA 1662
Query: 1223 SKENENIGDQLRQLQIQVRESIDGKLPSTDQQ 1254
+ + R L QVR S++ ++ DQQ
Sbjct: 1663 GLKTKEAEQTCRHLTAQVR-SLEAQVAHADQQ 1693
Score = 112 bits (281), Expect = 5e-24
Identities = 193/917 (21%), Positives = 379/917 (41%), Gaps = 122/917 (13%)
Query: 42 FNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAK 101
+ ++ QE+ Q + EQL+ L+++ E ++E + A K+ ++ H++
Sbjct: 817 YEDSQQEEAQYGAMFQEQLMT------------LKEECEKARQELQEAKEKVAGIESHSE 864
Query: 102 AKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK--HDKSSTEEEM-----EIEKIKHKLQ 154
+++ + E+ A L + E + K D S+ +E+M E+ +++ ++
Sbjct: 865 LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 155 EKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQA-QLSQTQAEQ 213
+ E T +L + +PA++ E++ + Q+ +F ST A Q + +AEQ
Sbjct: 925 KAGEQQETASRELVK----EPARAGDRQPEWL----EEQQGRQFCSTQAALQAMEREAEQ 976
Query: 214 AAQQVVREKDARFETQVRLHED------ELLQLV-----TQADVETEMQQKLRVLQRKLE 262
++ R + A E+Q + E+ E+ +L QAD+ E + + R
Sbjct: 977 MGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQN 1036
Query: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEA----EHNTLRNTVETEREESK 318
E V A + + L LT E ++Q L++ L+ +EA E LR TV+ +E+
Sbjct: 1037 ALNEQRVEFATLQEALAHALTEKEGKDQELAK-LRGLEAAQIKELEELRQTVKQLKEQ-- 1093
Query: 319 ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKT 378
L K E E A S Q E + E G L + S LEQ+ + + E+
Sbjct: 1094 --LAKKEKEHA----SGSGAQSEA---AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
Query: 379 SHILSLQK---TGQELQSACDALKDQNSKLLQD--KNEQAVQSAQT-IQQLEDQLQQKSK 432
S SL+ + E SA + L+ Q + Q+ ++ A+ SAQ + ++Q SK
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSK 1204
Query: 433 EISQFLNRLPLQQHETASQTSFPDVYNE-----GTQAVTEENIASLQKRVVELENEKGAL 487
++ ++ + E + S E Q + +E + KR+V E+EK
Sbjct: 1205 AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQK 1264
Query: 488 LLSSIEL--EELKAENEKLSSQITLL--EAQNRTGEADRE-VSEISIVDIANKRSSSAEE 542
L + L E + + + + + + L E Q+ EA+++ V+ ++ ++ AEE
Sbjct: 1265 LEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324
Query: 543 SGQDVL--ENTFSQKHKELSVLLLEMKEAQEEIAFL--------KLQLQGKRAEEADHEV 592
GQ++ + F QK + LS L LE Q ++ L +LQ + AE+ E
Sbjct: 1325 LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1384
Query: 593 LDQKEMK-----------QMEGEGIAPIKMKVFLEDT------------GQDFPLMPNEE 629
L+Q + Q E + P++ KV ++ + ++
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444
Query: 630 SSLPAVEKEQASTEHQSRTSEEISLNDAGV----ELKSTKQDGDKSLSAVPDIGQCHQDE 685
L + + R E+ L+ A EL + + D + L+ V Q E
Sbjct: 1445 GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE 1504
Query: 686 LERL-------KSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738
LE + K ++LE F + ++ +++ + +EE K ++ A
Sbjct: 1505 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQA 1564
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798
S+ + Q L V+ ++ AQ Q ++N +A+ ++ E H L E+
Sbjct: 1565 ----SKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQK---EQAAEHYKLQMEKA 1617
Query: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHIS 858
+ K ++ +++ L+ +Q + E L +LQ + E + RH++
Sbjct: 1618 KTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLT 1677
Query: 859 SKVEELSQALSQKELEI 875
++V L ++ + ++
Sbjct: 1678 AQVRSLEAQVAHADQQL 1694
Score = 78.6 bits (192), Expect = 1e-13
Identities = 139/686 (20%), Positives = 278/686 (40%), Gaps = 89/686 (12%)
Query: 8 LANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDI 67
L + H L+ + DQ + E Q ++E Q V +LK+
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELE--------------ELRQTVKQLKEQ 1093
Query: 68 IRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQ 127
+ +K+ + A E + KL+ +A+++ L + ++ + Q ++
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEA-LRAEVSKLEQQCQKQQEQADSL------ 1146
Query: 128 SEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPA-------QSST 180
E L S E + +E ++ +L+EK + + Q+ L AQ E A S
Sbjct: 1147 -ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA 1205
Query: 181 EME---EFVMMKQQLQEKEEFISTLQAQLS-----QTQAEQAAQQVVREKDARFETQVRL 232
E E + +Q+ + K IS+L+ ++S + E ++++ R A E +L
Sbjct: 1206 EDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL 1265
Query: 233 HEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQIL 292
E L A ++ L+ +++ E + + L+QELT+ +R + L
Sbjct: 1266 EERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEEL 1325
Query: 293 SQQL---QQMEAEHNTLRNTVETEREESKILL-EKMELEVAERKLSFHNLQEEMHHLLEQ 348
Q+L Q+ + +T++ E ++ L+ E + + ++L E H E+
Sbjct: 1326 GQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH-REE 1384
Query: 349 FEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSK---- 404
EQ+ QA L + Q+ E+ + ++T Q+L++ + +Q S
Sbjct: 1385 LEQSKQAAGGLRAEL-LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA 1443
Query: 405 --LLQDKNEQAVQSAQTIQQ-LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
LL ++N + A +Q LE +L Q ++ Q L + ++T +V E
Sbjct: 1444 HGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAV-----RADAETRLAEVQREA 1498
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
E + + + +GA + E + + E +KL++Q+ LE R E
Sbjct: 1499 QSTARELEVMTAK--------YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQR--EQT 1548
Query: 522 REVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581
++V E+S K+ + ++++ + + ++L + + E+Q+E L+ QL
Sbjct: 1549 KQVEELS------KKLADSDQASK--------VQQQKLKAVQAQGGESQQEAQRLQAQLN 1594
Query: 582 GKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAS 641
+A+ + E + QME K K + Q + + SL ++KE
Sbjct: 1595 ELQAQLSQKEQAAEHYKLQME-------KAKTHYDAKKQQNQELQEQLRSLEQLQKENKE 1647
Query: 642 TEHQS-RTSEEISLNDAGVELKSTKQ 666
++ R E L AG++ K +Q
Sbjct: 1648 LRAEAERLGHE--LQQAGLKTKEAEQ 1671
Score = 61.6 bits (148), Expect = 1e-08
Identities = 117/563 (20%), Positives = 226/563 (40%), Gaps = 123/563 (21%)
Query: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
AQ+ + ++ + RL+ L ++K+ A E K++ E+ DK + LH
Sbjct: 249 AQIAMMQQRIDRLALL---NEKQAASPLEP---------KELEELRDKNESLTMRLH--- 293
Query: 2692 GIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751
ET ++ +L + +M++K+ +++EN L+ +++ F + LQ++ +
Sbjct: 294 -------ETLKQ-CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELT 345
Query: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
EE + +++ L++Q L +E A L + LE+ N+ L
Sbjct: 346 EEHSKATQEW---------LEKQAQLEKELSAALQDKKC------------LEEKNEILQ 384
Query: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPST 2871
K QL SQL+D+ Q E+ + ++ + ++ AA +
Sbjct: 385 GKLSQLEEHLSQLQDNPPQ-------------EKGEVLGDVLQLETLKQEAATLAANNTQ 431
Query: 2872 SPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTK-A 2930
A V+ L+ + +LL E + +++ Q++ IT+L + L + +++ + A
Sbjct: 432 LQARVEMLETERGQQEA---KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
Query: 2931 FQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE 2990
Q L + S EL L I +DQ+L+ L+ +E
Sbjct: 489 SQAHGARLTAQVASLTSELTTLNA------------------TIQQQDQELAGLKQQAKE 530
Query: 2991 LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDS---LKEIHQKELR 3047
++ +QT +Q Q QAS Q L ++ E L + L LKE+ +K+
Sbjct: 531 KQAQLAQT----LQQQEQAS----------QGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576
Query: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107
+Q + L+ + SLRE L LEK+ +A L I
Sbjct: 577 TRQ---------DHAQQLATAAEEREASLRERDA----ALKQLEALEKE----KAAKLEI 619
Query: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAA 3167
Q+ + D Q S ++AQ++ ++V EL+ +E R ++ A
Sbjct: 620 -----LQQQLQVANEARD-----SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
+ ++ E Q+R + + R
Sbjct: 670 QAQVAELELQLRSEQQKATEKER 692
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 222 bits (566), Expect = 4e-57
Identities = 407/1990 (20%), Positives = 787/1990 (39%), Gaps = 291/1990 (14%)
Query: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
A++VEL L+ T E + +E L + Q +I SL + E + +L Q
Sbjct: 8 AQEVELTLETVIQTLESSVLCQEK-GLGARDLAQDAQITSLPALIRE--IVTRNLSQPES 64
Query: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
L + L LQ + LQ+ +S+ E+ L+ +E++ K E
Sbjct: 65 PVLLPATEMASLLSLQEENQLLQQELSRVED---LLAQSRAERDELAIKYNAVSERLEQA 121
Query: 1436 IKALHTQLEMQ-----AKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALI 1490
++ +LE Q ++ E +QLQ E ++K + E + + Q+ ++LQ ++
Sbjct: 122 LRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKIL 181
Query: 1491 SRKEALKENKSLQEELSLARGTIE----RLTKSLADVESQVSAQNKEKDTVLGRLALLQE 1546
K+ E L+++L G +E R T+ D+ES + +E+ R A L +
Sbjct: 182 QYKKRCSE---LEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQ----RSASLAQ 234
Query: 1547 ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQE 1606
L ++D++ NQ+LS + +T D + KE+E ++ A E +
Sbjct: 235 VNAMLREQLDQAGSANQALSED-------IRKVTNDWTRCRKELEHREA---AWRREEES 284
Query: 1607 KHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE 1666
+ E+ LL + V + V ++ +L G+L T +E L
Sbjct: 285 FNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLST 344
Query: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726
+ E E A ++Q +L+ + E ++LR +V D A++ M++ L K
Sbjct: 345 GLRLAESRAE-----AALEKQALLQAQLE-EQLRDKVLREKDLAQQQMQSDLD-----KA 393
Query: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG-NVSKQANLEATEKHDNQTNV 1785
+L E K+ + EKD +++++ + +E + +QA LE + Q +
Sbjct: 394 DLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTL 453
Query: 1786 ----------TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSA-------------KSAN 1822
+E G Q + G D+ + S R + PS + +
Sbjct: 454 RDLAQAVLSDSESGVQ-LSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPS 512
Query: 1823 PAVSKDFSS---HDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIST 1879
PA S + H ++ Q+ ++ R E SQ L TL Q+S
Sbjct: 513 PACSDSSTLALIHSALHKRQLQVQDMRGRY-----------EASQDL---LGTLRKQLSD 558
Query: 1880 KDGELKMLQEEVTKMN-------LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
+ E + L+E++ ++ ++ Q E+ R+ E EK +L L Q+A+
Sbjct: 559 SESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSL--QVAQ 616
Query: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY-- 1990
Q + + + E L++ + L++ LEEE++ V++ +V E+ + +
Sbjct: 617 ---------QQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
Query: 1991 LEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQT 2050
LE+++G K E++E L + LQ + E ++ E LE T
Sbjct: 668 LEQLEG--KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMT 725
Query: 2051 ----------ESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK 2100
+S L E+LAQ + A+L K L Q +A +
Sbjct: 726 KLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ----EAT 781
Query: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160
+ +E Q E ++ + + + LE L AE+ ++ ++++L LR E+ L+E +
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQA----QEALEQQLPTLRHERSQLQEQLA 837
Query: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220
++ L+ +++E++Q + V L + +L + + + ER+ +
Sbjct: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAERE-GRTLS 896
Query: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
+ +RL+++ L+ L ++ + +L+ +LE A+ + L K +
Sbjct: 897 EEATRLRLEKE---ALEGSLFEVQRQLAQLEARREQLE---------AEGQALLLAK--E 942
Query: 2281 TLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEG 2340
TL GE L Q+ T+ E A L+ EL + K ++ +E + +L
Sbjct: 943 TLTGELAGLRQQIIATQ--------EKASLDKELMAQK--------LVQAEREAQASLRE 986
Query: 2341 IIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIA 2400
E D+Q + E +L+A R ++L ++ +++++++ L ++E + IA
Sbjct: 987 QRAAHEEDLQRLQREKEAAWRELEAER---AQLQSQLQREQEELLARLEAEKEELSEEIA 1043
Query: 2401 ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV-DKTNQLMETLKTIKKENIQQKAQL 2459
L+Q+ D+ + L E+++ + L+E K A+ +K +L TI E +QK
Sbjct: 1044 ALQQERDEGLL----LAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDA 1099
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
S + ++DR + E R L E EAAA + +E+R L+
Sbjct: 1100 QS--------RQEQDRSTVNALTSELRDLRAQRE------EAAAAH---AQEVRRLQEQA 1142
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKES 2579
DL + E + R L + +D +++LLE Q KL+ES
Sbjct: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQ---------------RKLRES 1187
Query: 2580 EEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEE 2639
+E E R+ L+ + +KE E+L+ S +L V + E LK+ E
Sbjct: 1188 QEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESE------RISLKLANE 1241
Query: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699
+ ++++A LEE V KEA + +++ + L+ + +R + +
Sbjct: 1242 D----------KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLE-ARRELQELRRQMK 1290
Query: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR 2759
+ L R+L E++ +L + + K + + + + S + +EL +R
Sbjct: 1291 MLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR 1350
Query: 2760 KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLH 2819
K L+EQ R R+ L + TE+ L H L +L + +
Sbjct: 1351 K----------LQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAE 1400
Query: 2820 LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS--------------------- 2858
L +L + + Q +A ++ +R +L R +
Sbjct: 1401 LGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460
Query: 2859 ----------------------EEGKQRSAAQPSTSPA----EVQSLKKAMSSLQNDRDR 2892
G Q + P+TSPA + ++++ A+ +
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRS 1520
Query: 2893 LLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQL 2952
+E L+ Q +N+++ E+ +A+ + + Q E + S L +
Sbjct: 1521 AQRERDELRTQTSALNRQLAEM---EAERDSATSRARQLQKAVAESEEARRSVDGRLSGV 1577
Query: 2953 RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPE 3012
+ E + E RR + + + LQ ELR+S + +K + +
Sbjct: 1578 QAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
Query: 3013 TSASP--DGSQNLVYETELLRTQLNDSLKE----IHQKELRIQQLNSNFSQLLEE----- 3061
D S++ + EL R L L+ + +E + Q L L +
Sbjct: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSE 1697
Query: 3062 --KNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
TL + + + +L + ++ G L + L + + + A LN +K
Sbjct: 1698 VKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSAS-LNSTRDKNLHLQKAL 1756
Query: 3120 VHRKSDPEELRE----PQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAE 3175
+ D + L+E +Q+ SEA++Q + ++V LR + + QRV AE L
Sbjct: 1757 TACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR 1816
Query: 3176 EQIRRLEHSE 3185
E +R+ + E
Sbjct: 1817 EVLRQRQEGE 1826
Score = 218 bits (554), Expect = 1e-55
Identities = 412/2034 (20%), Positives = 851/2034 (41%), Gaps = 241/2034 (11%)
Query: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAE---RQRRLDYESQTAHDNLLTEQI 798
LS+ +L E++ + L+ + + L+ L+ E Q R + + N ++E++
Sbjct: 59 LSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERL 118
Query: 799 HSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRS---LQSQLQNKESEVLEGAERVR 855
L+ +L+ E L+R L+ QLQ +++ + +
Sbjct: 119 EQAL---------------RLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQ 163
Query: 856 HISSKVEELSQALSQKELEITK----MDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
+ +L Q L K L+ K ++Q LLE+ ++E QQ + + TE S +
Sbjct: 164 EGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRD-----TEHSQDLE 216
Query: 912 EKMVQLNEEK---FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSP 968
+++L EE+ SL L+EQL+ A +A E + + + ++ +
Sbjct: 217 SALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREA 276
Query: 969 AGQISKEELQHEFD--------LLKKENEQRKRKLQAALINRKELLQ------RVSRLEE 1014
A + +E F L ++ R+ + + ++LLQ R SR +
Sbjct: 277 AWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQ 336
Query: 1015 EL----------------ANLKDESKKEIPLSETERGEVEEDKE------NKEYSEKCVT 1052
E A L+ ++ + L E R +V +K+ + + ++
Sbjct: 337 EAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLS 396
Query: 1053 SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ-----ALVKQMNQTLQDKTNQ 1107
++ E+ + +K+ + ++ +E + KDL EKL A E + AL + + LQ
Sbjct: 397 ARVTELGLAVKR-LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLR- 454
Query: 1108 IDLLQAEISENQAIIQKLITSNT-DASDGDSVALVKETVVISP----PCTGSSEHWKPE- 1161
DL QA +S++++ +Q + T DAS+G L + P P G S P
Sbjct: 455 -DLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSP 513
Query: 1162 --LEEKILAL---EKEKEQLQ--------KKLQEALTSRKAILKKAQEKERHLREELKQQ 1208
+ LAL K QLQ + Q+ L + + L ++ + R L E+L++
Sbjct: 514 ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL 573
Query: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLF 1268
+D + + ++ +E + + +L + + ++ L QQ E L
Sbjct: 574 RDKTDGAMQAHEDAQREVQRLRSA-NELLSREKSNLAHSLQVAQQQ--AEELRQEREKLQ 630
Query: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSST 1328
A E+ Q L E A+Q G A+++ +L+ + +LE K S
Sbjct: 631 AAQEELRRQ---RDRL------EEEQEDAVQDG---ARVRRELERSHRQLEQLEGKRSVL 678
Query: 1329 TSELTKKSEEVFQL---QEQINKQGLEIESLKTVSHEAEVHAESLQQKL--ESSQLQ--I 1381
EL + E + + ++ + + E+ T + V E KL E + LQ +
Sbjct: 679 AKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSL 738
Query: 1382 AGLEHLRE--LQPKLDELQKLISKKEEDVSYLSGQL--SEKEAALTKIQTEIIEQEDLIK 1437
+ L L E Q KLD L +L+++ EE+ S L G+ +E+EA + + + E +E+ L +
Sbjct: 739 SKLSALNESLAQDKLD-LNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQ 797
Query: 1438 ALHTQ-LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEAL 1496
+ Q LE + ++ + L+ +L ++ + ++ E+ Q+ R+L ++A
Sbjct: 798 EVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA---QLSRQLSGREQELEQAR 854
Query: 1497 KENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL---IT 1553
+E + E L A E L K A + Q+ A +E T+ L+ E++ L +
Sbjct: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF 914
Query: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613
E+ R L + L + E L+ + L KE L E+ L+ IA + E KEL
Sbjct: 915 EVQRQLAQ---LEARREQLEAEGQALLLAKETLTGELAGLRQQIIA-TQEKASLDKELMA 970
Query: 1614 EYEILLQSYENVSNEAERIQHV--VEAVRQEKQELYGKLRSTEAN-----KKETEKQLQE 1666
+ + + S +R H ++ +++EK+ + +L + A ++E E+ L
Sbjct: 971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Query: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726
E E EE+ E++ + + + +L E E + + E + S A++
Sbjct: 1031 LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISL 1090
Query: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVT 1786
E+ER K + ++ ++ +S ++ +L+ E++DL+ Q E EA H +
Sbjct: 1091 EMERQKRDAQSRQEQDRSTVN---ALTSELRDLRAQRE---------EAAAAHAQEVRRL 1138
Query: 1787 EEGTQSIPGETE----EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI 1842
+E + + + + E + L R + A K S + Q+
Sbjct: 1139 QEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
Query: 1843 DQLKERIAGLEEEKQKNKEFSQTL-------ENEKNTLLSQISTKDGELKMLQEEVTKMN 1895
+L+ + +E++ + ++ L E+E+ +L K+ +L +L+E T +
Sbjct: 1199 GELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVG 1258
Query: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEE----------RLMNQLAELNG--SIGNYCQD 1943
+++ L V + + A E +L RL +LAEL G ++G +
Sbjct: 1259 KEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318
Query: 1944 VTDAQ---IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY--LEKIQGAQ 1998
+ + ++ LL+ E +L+ EL+ +++L +++ + + R+ LE+ +G +
Sbjct: 1319 ESRRETLGLRQRLLKGEA-SLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTE 1377
Query: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
K+ HA+ L+ L+ + E +L + + LE + +E + ++ L
Sbjct: 1378 KQ--QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGG 1435
Query: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ----SNKESVKS 2114
+ L + + + A V + A + L L+ S S
Sbjct: 1436 LRSALRRGLGLGRAPSP--APRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGP 1493
Query: 2115 QMKQKDEDLE-RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV 2173
DL+ + A + L+E ++ Q + D LR + L + E++ +
Sbjct: 1494 ATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRA 1553
Query: 2174 QQLQENLDSTVTQLAAFTKSMSSLQDD---RDRVIDEAKKWERKFSDAIQSKEEEIRLKE 2230
+QLQ+ + + + +S +Q + ++ + +++ R D + + E ++ E
Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
Query: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK--- 2287
++++ +M + +L+ + RL+ ES+ +++LQ++ +L+GE +
Sbjct: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT-VKLELQRR---SLEGELQRSR 1669
Query: 2288 ----ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR 2343
+ +Q + + S Q ++A E + +L+ + L+ +L K +E +G L +R
Sbjct: 1670 LGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729
Query: 2344 -QQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE------------QKIISLLSG 2390
EA Q+S + +L + LT+ H+ ++E +K S L
Sbjct: 1730 GLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGE 1789
Query: 2391 KEEAIQVAIAEL---RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
+ + ++ +A+L R + + ++++L +L Q +E +K D+ L E L +
Sbjct: 1790 QVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGS 1849
Query: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
+++ Q +A+ +S L+ DR + ++E L + +L +AE +
Sbjct: 1850 LQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRL----SAEKGR 1905
Query: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE-LE 2566
L + G + + + +L+A+++ + + D+QQ+QL +LQQ E L
Sbjct: 1906 LDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL---ELQQEVERLR 1962
Query: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTA 2620
+ A+ E L+ E A+ ++ + L +++ +LK + Q R+ +A
Sbjct: 1963 SAQAQTERTLEARERAH----------RQRVRGLEEQVSTLKGQLQQELRRSSA 2006
Score = 211 bits (536), Expect = 1e-53
Identities = 411/2063 (19%), Positives = 839/2063 (40%), Gaps = 251/2063 (12%)
Query: 1051 VTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT----LQDKTN 1106
+TS I + + +S+ E + ++ L+ +E+ Q L +++++ Q +
Sbjct: 44 ITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAE 103
Query: 1107 QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKI 1166
+ +L + ++ + Q L + + LV+++V + ++ +L+
Sbjct: 104 RDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQ 163
Query: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE---ELKQQK---DDYNRLQEQFD 1220
+++ QL ++LQ + K K+ E E+ L E EL+QQ+ ++++ E
Sbjct: 164 EGQQRQA-QLVQRLQGKILQYK---KRCSELEQQLLERSGELEQQRLRDTEHSQDLESAL 219
Query: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQH-HTQPV 1279
+ +E + L Q+ +RE +D ++ S+ L E + K T +
Sbjct: 220 IRLEEEQQRSASLAQVNAMLREQLD---------QAGSANQALSEDIRKVTNDWTRCRKE 270
Query: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339
LE W E +A + + + ++ E+K+ T +L + E+
Sbjct: 271 LEHREAA-WRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF-TERDLLQLGGEL 328
Query: 1340 FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQK 1399
+ + + GL L T AE AE+ +K Q Q+ E LR+ + +L +
Sbjct: 329 ARTSRAVQEAGL---GLSTGLRLAESRAEAALEKQALLQAQLE--EQLRDKVLREKDLAQ 383
Query: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQV 1459
+ + D + LS +++E A+ +++ + +E++ + K L +LE +
Sbjct: 384 QQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA-------------L 430
Query: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519
E ++++ E+ QQ R L A++S E+ + + + G++ L+
Sbjct: 431 ESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQ 490
Query: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579
+ S+ + + G D + S L + L + G
Sbjct: 491 RTPSPPRRSSPGRGRSPRRGPSPACS---DSSTLALIHSALHKRQLQVQ------DMRGR 541
Query: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
E + L+ + S +E +E+ + L+ + + +Q++E+ E +R++ E +
Sbjct: 542 YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELL 601
Query: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699
+EK L LQ A+Q+ EE++++ K +++ EL + DRL
Sbjct: 602 SREKSNL--------------AHSLQVAQQQAEELRQEREKLQAAQE----ELRRQRDRL 643
Query: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
E E + A ++ ELER + E L K + L++E+ ++
Sbjct: 644 EEE-----------QEDAVQDGARVRRELERSHRQLEQLEGK-------RSVLAKELVEV 685
Query: 1760 KHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM--STRPTCSESVPS 1817
+ + +A L+ + V E T++ G E + S++ + + +S+
Sbjct: 686 REALS-----RATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSK 740
Query: 1818 AKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQI 1877
+ N ++++D ++N + Q+++ K + G +Q+ E T+ E+ L ++
Sbjct: 741 LSALNESLAQDKL---DLNRLVAQLEEEKSALQG----RQRQAEQEATVAREEQERLEEL 793
Query: 1878 STKDGELKMLQEEVTKMNL-----LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
L++EV + L + +Q QE L + T E+ L+E+L +
Sbjct: 794 R--------LEQEVARQGLEGSLRVAEQAQEALEQQLP---TLRHERSQLQEQLAQLSRQ 842
Query: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSE----------LEEEKQQLVKEKTKV 1982
L+G Q +AQ + E LE + + E E E + L +E T++
Sbjct: 843 LSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRL 902
Query: 1983 ESEIRKEYLE------KIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKDCIRYQE 2033
E KE LE + Q AQ E + E Q LL K+ E+ L++ I QE
Sbjct: 903 RLE--KEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
Query: 2034 KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAAR 2093
K S L++ + A + VQ E + + ++ A + ++ + + A+++ L + ++
Sbjct: 961 KAS-LDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQ 1019
Query: 2094 VLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKV 2153
+ + +L L++ KE + ++ ++ + L AE + + + + AL + +
Sbjct: 1020 LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
Query: 2154 HLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER 2213
++ I + + ++ ++ Q QE STV A T + L+ R+ + R
Sbjct: 1080 GTRHSLATISLEMERQKRDAQSRQEQDRSTVN---ALTSELRDLRAQREEAAAAHAQEVR 1136
Query: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR--LEHDKQIWESKAQTE 2271
+ +Q + ++ + D+C ++LR +E+ + + R LE +++ ES+ E
Sbjct: 1137 R----LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
Query: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA----KLESELKSLKDQLTDLSNS 2327
VQ Q+ GE + L + + R S EL K ESE SLK D
Sbjct: 1193 VQRQEA------GELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK 1246
Query: 2328 ---LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
LE+ + G G +R +++ S+ + +L+ ++ + + + ++
Sbjct: 1247 LALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAEL 1306
Query: 2385 ISLLSGKEEAIQVAIAE---LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL 2441
L+ E A + + E LRQ+ K LE + + + L+E+ + + +L
Sbjct: 1307 QGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRL 1366
Query: 2442 METLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL-IQE 2500
+ +L+ + QQ + + + + + E R + E ++ +Q
Sbjct: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR 1426
Query: 2501 AAAENNKLKEEIRGLRSHM-DDLNSENA------------KLDAELIQYREDLNQVITIK 2547
AAE ++ GLRS + L A DA E LN T++
Sbjct: 1427 RAAE-----AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLE 1481
Query: 2548 ---DSQQKQLLEVQLQQNKELENKYAK-----LEEKLKESEEANEDLRRSFNALQEEKQD 2599
SQ + +L+ + + ++L+ ++ ++LR +AL + +
Sbjct: 1482 CSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAE 1541
Query: 2600 LSKEIESLKVSISQLTRQVTALQE-----EGTLGLYHAQLKVKEEEVHRLSALFSSSQKR 2654
+ E +S QL + V +E +G L A+L ++EE V R ++ +
Sbjct: 1542 MEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQ 1601
Query: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+A LE L + E +I K+K L D ++ + +E R +L
Sbjct: 1602 VATLERSLQATESELRASQEKI-SKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRS 1660
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE- 2773
+E +L AQ Q+ + SLQ + + L+ + LA+++E
Sbjct: 1661 LEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
Query: 2774 QGLLN---RERDALLSETAFSMNSTEENSLSHLEK-----------LNQQLLSKDEQLLH 2819
+G L R L++++ S+NST + +L HL+K L ++L + + L
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNL-HLQKALTACEHDRQVLQERLDAARQALSE 1779
Query: 2820 LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSL 2879
Q QVQ+ +A L+ +R +L++ R+ +Q A A + ++
Sbjct: 1780 ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEA------AALNTV 1833
Query: 2880 KKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELR 2939
+K LQ++R L + L +LQ+ Q+ E E+ ++ L+ +D+ A + +++
Sbjct: 1834 QK----LQDERRLLQERLGSLQRALAQLEAEKREVE--RSALRLEKDRV-ALRRTLDKVE 1886
Query: 2940 QENLSWQHELHQLRMEK---------SSWEIHERRMKEQYLMA--------------ISD 2976
+E L + +L EK + E+ E + + Q L A D
Sbjct: 1887 REKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVD 1946
Query: 2977 KDQQLSHLQNLIRELRSSSSQTQ 2999
QQ LQ + LRS+ +QT+
Sbjct: 1947 AQQQQLELQQEVERLRSAQAQTE 1969
Score = 194 bits (492), Expect = 2e-48
Identities = 434/2182 (19%), Positives = 884/2182 (40%), Gaps = 278/2182 (12%)
Query: 54 LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEE 113
LA A+++ + L+ +I+ + + +++ L A D A++TSL I E
Sbjct: 5 LARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQD-----------AQITSLPALIRE 53
Query: 114 M------KAQGGTVLP-TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQ-EKEELI---ST 162
+ + + +LP TE S L + ++ +E +E + + + E++EL +
Sbjct: 54 IVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNA 113
Query: 163 LQAQLTQAQAEQPAQSSTE-----MEEFVMMKQQLQEKE-EFISTLQAQLSQTQAEQAAQ 216
+ +L QA +P + T+ + + V +++QLQE++ + LQA Q +
Sbjct: 114 VSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLV 173
Query: 217 QVVREKDARFETQVRLHEDELLQ----LVTQADVETEMQQKLRVLQRKLEEHEESLVGRA 272
Q ++ K +++ + E +LL+ L Q +TE Q L +LEE ++ A
Sbjct: 174 QRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLA 233
Query: 273 QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
QV +L+++L A NQ LS+ ++++ + R LE E +
Sbjct: 234 QVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKE-----------LEHREAAWRREE 282
Query: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
SF+ H L + L S ++ ++ + L +T + +Q
Sbjct: 283 ESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGE------LARTSRAVQ 336
Query: 393 SACDALKDQNSKLLQDKNEQAVQSAQTIQ-QLEDQLQQKSKEISQFLNRLPLQQHETASQ 451
A L +L + + E A++ +Q QLE+QL+ K L L Q + S
Sbjct: 337 EAGLGL-STGLRLAESRAEAALEKQALLQAQLEEQLRDK------VLREKDLAQQQMQSD 389
Query: 452 TSFPDVYNEGTQ---AVTEENIASLQKRVVELENEKGALLLSSIELEELKA----ENEKL 504
D+ T+ AV +L+K V + + L S+ L+E A + E L
Sbjct: 390 LDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGL 449
Query: 505 S------SQITLLEAQNRT----GEADREVSEISIVDIANKRSSSAEESGQDVLENT--- 551
+Q L ++++ E + S S+ ++ +R+ S +
Sbjct: 450 QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRR 509
Query: 552 -FSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAE-EADHEVLD--QKEMKQMEGEGIA 607
S + S L L + +LQ+Q R EA ++L +K++ E E A
Sbjct: 510 GPSPACSDSSTLALIHSALHKR----QLQVQDMRGRYEASQDLLGTLRKQLSDSESERRA 565
Query: 608 PIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI--SLNDAGVELKSTK 665
+ L D M E + V++ +++ E SR + SL A + + +
Sbjct: 566 LEEQLQRLRDKTDG--AMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELR 623
Query: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLI 725
Q+ +K Q Q+EL R + ++ E + + + + L+ +++ L
Sbjct: 624 QEREKL--------QAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKR 675
Query: 726 EEFKKNADNNSSAFTALSEERDQLLSQVKELS-MVTELRAQVKQLEMNLAEAERQRRLDY 784
K A + + +RD L ++ E++ +T+ A +LE+++ + R
Sbjct: 676 SVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKL-RAEEASL 734
Query: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ--N 842
+ + + L E + ++ ++E ++ L Q Q +++T+ R Q +L+
Sbjct: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
Query: 843 KESEV----LEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV----ETLQQ 894
E EV LEG+ RV + E L Q L E +++ + L + R + + L+Q
Sbjct: 795 LEQEVARQGLEGSLRVAEQAQ--EALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQ 852
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
E +QV + + EK L +E L V++ + + LS EEA + ++E++
Sbjct: 853 ARREAQRQVEALERAAREKEA-LAKEHAGLAVQLVAAEREGRTLS--EEATRLRLEKE-- 907
Query: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
A + S E+Q + L+ EQ + + QA L+ ++ L ++ L +
Sbjct: 908 --------------ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
++ ++++ + KE + + +E + L++ + E +LQ
Sbjct: 954 QIIATQEKASLD-----------------KELMAQKLVQAEREAQASLREQRAAHEEDLQ 996
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134
+++ EK AA + +A Q+ LQ Q +LL +E + + +++ + +
Sbjct: 997 RLQR---EKEAAWRELEAERAQLQSQLQ--REQEELLARLEAEKEELSEEIAALQQERDE 1051
Query: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKI-----------LALEKEKEQLQKKLQEA 1183
G +A ++ +S E K L EK+ L +E++K Q + ++
Sbjct: 1052 GLLLAESEKQQALS-----LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQD 1106
Query: 1184 LTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES 1243
++ A+ + ++ E + RLQEQ + K+ ++ + +L+ Q+R
Sbjct: 1107 RSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLL 1166
Query: 1244 IDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTS 1303
D + ++E + L E + E Q L +++ AL+ S
Sbjct: 1167 EDAR--DGLRRELLEAQRKLRE----SQEGREVQRQEAGELRRSLGEGAKEREALR--RS 1218
Query: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
++++ +K+ E+E++ L+L K +++ L+E G E L+T E
Sbjct: 1219 NEELRSAVKKAESERISLKLANED-------KEQKLALLEEARTAVGKEAGELRTGLQEV 1271
Query: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423
E + +LE+ + L+EL+ ++ L ++ +++ L G+L+ E A
Sbjct: 1272 E------RSRLEARR-------ELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318
Query: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
+ + E + + LE+ +E ++LQ E+ GE ++++
Sbjct: 1319 ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQ----------EQEGEFRTRERRLLG 1368
Query: 1484 KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543
L+ A + K+ L + L+ +L AR L L+ E + E L R+ +
Sbjct: 1369 SLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAE----LARVEV 1424
Query: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603
+ + + + +L L + + G E L S E +
Sbjct: 1425 QRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSP 1484
Query: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQ 1663
+ + EAVR +E +LRS + + E Q
Sbjct: 1485 GSQPPS-------------PGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQ 1531
Query: 1664 LQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS 1723
+++ EM E R A S+ +++ + E++ R V G + E L +
Sbjct: 1532 TSALNRQLAEM-EAERDSATSRARQLQKAVAESEEARRSVD--GRLSGVQAELALQEESV 1588
Query: 1724 MKEELER--VKMEYETLSKKFQSLMSEKDSLSEEVQDLK---HQIEGNVSKQANLEATEK 1778
+ E ER + TL + Q+ SE + E++ +K ++EG+ K+ E +
Sbjct: 1589 RRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGD--KRRLKEVLDA 1646
Query: 1779 HDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY 1838
+++T E +S+ GE ++ L +S R ++++ + D S +
Sbjct: 1647 SESRTVKLELQRRSLEGEL-QRSRLGLSDREAQAQALQDRVDSLQRQVAD--SEVKAGTL 1703
Query: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTL-ENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897
+++L +A +EE + ++ + L E + S ST+D L LQ+ +T
Sbjct: 1704 QLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLH-LQKALTACEHD 1762
Query: 1898 NQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
Q +QE L + A ++ L E Q+ L G +V D +++ E +
Sbjct: 1763 RQVLQERLDAARQALSEARKQSSSLGE----QVQTLRG-------EVADLELQRVEAEGQ 1811
Query: 1958 MKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEK 2017
++ L++ + + +E + + K++ E + L++ G+ LQ L +
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDE--RRLLQERLGS------------LQRALAQL 1857
Query: 2018 QQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKD----------LEITKENLAQAV 2067
+ E +++++ +R ++ AL RT+ +E + S +D L+ T +
Sbjct: 1858 EAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELEL 1917
Query: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2127
++ +L + V+L+ + S A++ D + + ELQ E ++S Q ER L
Sbjct: 1918 AEAQRQIQQLEAQVVVLEQSHS-PAQLEVDAQQQQLELQQEVERLRSAQAQ----TERTL 1972
Query: 2128 EQAEEKHLKEKKNMQEKLDALR 2149
E E H + + ++E++ L+
Sbjct: 1973 EARERAHRQRVRGLEEQVSTLK 1994
Score = 189 bits (481), Expect = 3e-47
Identities = 431/2112 (20%), Positives = 835/2112 (39%), Gaps = 346/2112 (16%)
Query: 1253 QQESCSSTPGL-EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQL 1311
Q +S P L E + + Q + +L + S E+ LQ +++++ L
Sbjct: 40 QDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQ--QELSRVEDLL 97
Query: 1312 KEIEAEKVELELKVSSTTSELTKKSE-EVFQLQEQINKQGL---EIESLKTVSHEAEVHA 1367
+ AE+ EL +K ++ + L + E +L+ Q +GL +E + + E +
Sbjct: 98 AQSRAERDELAIKYNAVSERLEQALRLEPGELETQ-EPRGLVRQSVELRRQLQEEQASYR 156
Query: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK--------- 1418
LQ E Q Q + ++ LQ K+ + +K S+ E+ + SG+L ++
Sbjct: 157 RKLQAYQEGQQRQA---QLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQ 213
Query: 1419 --EAALTKIQTEIIEQEDLIKA---LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGE 1473
E+AL +++ E L + L QL+ + + ++ + + +E+
Sbjct: 214 DLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEH 273
Query: 1474 ESRAKQQIQRKLQA--------------------ALISRKEALKENKSLQEELSLARGTI 1513
A ++ + A L+S + E LQ LAR T
Sbjct: 274 REAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELAR-TS 332
Query: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE-----RDKLITEMD------RSLLEN 1562
+ ++ + + + + L + ALLQ + RDK++ E D +S L+
Sbjct: 333 RAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK 392
Query: 1563 QSLSSSCESLKLALEGLTEDK-------EKLVKEIESLKSSKIAESTEWQEKHKE-LQKE 1614
LS+ L LA++ L + + L +++E+L+S ++ E + + E LQ+
Sbjct: 393 ADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQT 452
Query: 1615 YEILLQSYENVSNEAERI---QHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEM 1671
L Q+ + S ++ + +A + L G+ + + +
Sbjct: 453 LRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPS 512
Query: 1672 EEMKEK--MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE 1729
+ + + ++ L++++ R A G K+ ++ S +++E+L+
Sbjct: 513 PACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE-SERRALEEQLQ 571
Query: 1730 RVK-------MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ 1782
R++ +E ++ Q L S + LS E +L H ++ V++Q E ++ +
Sbjct: 572 RLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ--VAQQQAEELRQEREKL 629
Query: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI 1842
EE + EEQ+ AV E+ +Q+
Sbjct: 630 QAAQEELRRQRDRLEEEQED---------------------AVQDGARVRRELERSHRQL 668
Query: 1843 DQLKERIAGLEEEKQKNKEF-------SQTLENEKNTLLSQISTKDGELKMLQEEVTKMN 1895
+QL+ + + L +E + +E L+ EK + ++ + L+ +TK+
Sbjct: 669 EQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLR 728
Query: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLE 1955
+Q+ LS+++ L E+ ++K DL RL+ QL E + L+
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLN-RLVAQLEE-----------------EKSALQ 770
Query: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+ ++ + EE+++L E+ ++E E+ ++ LE G+ A++ QE L
Sbjct: 771 GRQRQAEQEATVAREEQERL--EELRLEQEVARQGLE---------GSLRVAEQAQEAL- 818
Query: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQA 2075
+Q++ L+ + + QE+++ L R + E +++++ + E L +A ++
Sbjct: 819 --EQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
Query: 2076 ELASFKVLLDDTQSEAARVL--ADNLKLKKE-LQSNKESVKSQMKQKDEDLERRLEQAEE 2132
E A V L + E + A L+L+KE L+ + V+ Q+ Q LE R EQ E
Sbjct: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ----LEARREQLEA 932
Query: 2133 KH---LKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK---DKEVQQLQENLDSTVTQ 2186
+ L K+ + +L LR++ + +E + +L+K+ K VQ +E S Q
Sbjct: 933 EGQALLLAKETLTGELAGLRQQIIATQE-----KASLDKELMAQKLVQAEREAQASLREQ 987
Query: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH 2246
AA + + LQ +++ E + + +Q ++EE+ L ++
Sbjct: 988 RAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL-------------LARLEAE 1034
Query: 2247 MEELKINISRLEHDKQ----IWESKAQTEVQLQQK----VCDTLQGENKELLSQLEETRH 2298
EEL I+ L+ ++ + ES+ Q + L++ + + L G L + E
Sbjct: 1035 KEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMER 1094
Query: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY-- 2356
+Q+ + S + +L +L DL E+ +++Q D+ + S
Sbjct: 1095 QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLR 1154
Query: 2357 --EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE 2414
E+L T L+ + L E+ ++K+ G+E Q A ELR+ + KE E
Sbjct: 1155 EAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA-GELRRSLGEGAKERE 1213
Query: 2415 NLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRD 2474
L EE + AV K +LK + E+ +QK L
Sbjct: 1214 ALRRSNEEL--------RSAVKKAESERISLK-LANEDKEQKLAL--------------- 1249
Query: 2475 RIVGDYQQLEERHLSIILEKDQL---IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDA 2531
LEE ++ E +L +QE + + E++ LR M L+SEN +L
Sbjct: 1250 --------LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGR 1301
Query: 2532 ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN 2591
EL + L + + + +K+ L + L A LE +E + A L+
Sbjct: 1302 ELAE----LQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG 1357
Query: 2592 ALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651
+ ++ L +E + + Q L+ +L+ E L S++
Sbjct: 1358 EFRTRERRLLGSLEEARGTEKQQLDHARGLE---------LKLEAARAEAAELGLRLSAA 1408
Query: 2652 QKRIAELEEEL--VCVQKEAAK-KVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAEL 2708
+ R LE EL V VQ+ AA+ ++G + L++ L G+ R +
Sbjct: 1409 EGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGL-------GLGRAPSPAPRPVPGSP 1461
Query: 2709 ARD----------------------------------------------LVEMEQKLLMV 2722
ARD L E Q+L
Sbjct: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSA 1521
Query: 2723 TKENKGLTAQIQSFGRSMSSLQNSRDHANE----------ELDELKRKYDASLK----EL 2768
+E L Q + R ++ ++ RD A E +E +R D L EL
Sbjct: 1522 QRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAEL 1581
Query: 2769 AQLKEQGLLN--RERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2826
A L+E+ + RER A L + A T E SL E +L + E++ S+++
Sbjct: 1582 A-LQEESVRRSERERRATLDQVA-----TLERSLQATES---ELRASQEKI----SKMKA 1628
Query: 2827 SYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGK-QRSAAQPSTSPAEVQSLKKAMSS 2885
+ +++ + + + + + +LE R+S EG+ QRS S A+ Q+L+ + S
Sbjct: 1629 NETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS 1688
Query: 2886 LQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF-QIMQEELRQENLS 2944
LQ + LQ ++N + ++ + L+ DK + + + + N +
Sbjct: 1689 LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALR---DKVRGLTEALAQSSASLNST 1745
Query: 2945 WQHELHQLRMEKSSWEIHERRMKEQYL----MAISDKDQQLSHLQNLIRELRSSSSQTQP 3000
LH L+ ++ E H+R++ ++ L A+S+ +Q S L ++ LR + +
Sbjct: 1746 RDKNLH-LQKALTACE-HDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLEL 1803
Query: 3001 LKVQYQ----------RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQ 3050
+V+ + RQ +A+ + Q L E LL+ +L + + Q E ++
Sbjct: 1804 QRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKRE 1863
Query: 3051 LNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVA 3110
+ + +L +++ L L RE + + D + A + + L L + A
Sbjct: 1864 VERSALRLEKDRVALRRTLDKVE---REKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA 1920
Query: 3111 PGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENA 3170
Q+ + E+ P Q +AQQQ +QEV LR + A E A
Sbjct: 1921 QRQIQQLEA--QVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERA 1978
Query: 3171 LSVAEEQIRRLE 3182
+++R LE
Sbjct: 1979 ---HRQRVRGLE 1987
Score = 176 bits (447), Expect = 3e-43
Identities = 390/1916 (20%), Positives = 757/1916 (39%), Gaps = 235/1916 (12%)
Query: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADN- 91
+ D+E E+ Q+R A Q+ ++R++ Q ++AL E+ + N
Sbjct: 208 DTEHSQDLESALIRLEEEQQRSASLAQV----NAMLREQLDQAGSANQALSEDIRKVTND 263
Query: 92 --KIKKLKLHAKA----KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEM- 144
+ +K H +A + S N Y ++ +L + +L K TE ++
Sbjct: 264 WTRCRKELEHREAAWRREEESFNAYFSNEHSRL-LLLWRQVVGFRRLVSEVKMFTERDLL 322
Query: 145 ----EIEKIKHKLQEKEELIST---LQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEE 197
E+ + +QE +ST L +A E+ A ++EE + K L+EK+
Sbjct: 323 QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKV-LREKDL 381
Query: 198 FISTLQAQLSQTQ-----------AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADV 246
+Q+ L + ++ +Q + + + +L E L+L QA +
Sbjct: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441
Query: 247 ETE----MQQKLRVLQRKLEEHEES---LVGRAQVVDLLQQELTAAEQRNQILSQQLQQM 299
ETE +QQ LR L + + ES L G + D L + +
Sbjct: 442 ETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSP 501
Query: 300 EAEHNTLRNTVETEREESKILL-----EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQ 354
+ R + S + L K +L+V + + + Q+ + L +Q +
Sbjct: 502 GRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSES 561
Query: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414
+ LE + L K M+ Q+ Q L+SA + L + S L + A
Sbjct: 562 ERRALEEQLQRLRDKTDGAMQAHED----AQREVQRLRSANELLSREKSNLAHSL-QVAQ 616
Query: 415 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ 474
Q A+ ++Q ++LQ +E+ + +RL +Q + + E + E+
Sbjct: 617 QQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRS 676
Query: 475 KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVS-------EI 527
EL + AL ++++ + L+AE +++ +T EA G + E+S E
Sbjct: 677 VLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA----GRVELELSMTKLRAEEA 732
Query: 528 SIVDIANKRSSSAEESGQDVLE--NTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRA 585
S+ D +K S+ E QD L+ +Q +E S L ++A++E + +
Sbjct: 733 SLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR-----EEQ 787
Query: 586 EEADHEVLDQKEMKQ-MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEH 644
E + L+Q+ +Q +EG + + LE Q P + +E S L +EQ +
Sbjct: 788 ERLEELRLEQEVARQGLEGSLRVAEQAQEALE---QQLPTLRHERSQL----QEQLAQLS 840
Query: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD------ELERLKSQILELEL 698
+ + E L A E + + +++ + + H ER + E
Sbjct: 841 RQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT 900
Query: 699 NFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE----RDQLLSQVK 754
+E E +L E ++++ L E+ + A L+ E R Q+++ +
Sbjct: 901 RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE 960
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDY-ESQTAHDNLLTEQIHSLSIEAKSKDVKIE 813
+ S+ EL AQ L +AER+ + E + AH+ E + L E ++ ++E
Sbjct: 961 KASLDKELMAQ------KLVQAEREAQASLREQRAAHE----EDLQRLQREKEAAWRELE 1010
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLE-GAERVRHISSKVEELSQALSQKE 872
+ +L QLQ EQ L+ L+++ + E+ ER + E QALS KE
Sbjct: 1011 AERAQLQS-QLQ-REQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKE 1068
Query: 873 LEITKMDQLLLEKKRDVETLQ----------QTIEEKDQQ-VTEISFSMTEKMVQLNEEK 921
E T + + L+ + + T+ Q+ +E+D+ V ++ + + Q E
Sbjct: 1069 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128
Query: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
+ E++ L+EQ L + ++ + EE L+ + A + EL
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEE-------LRTQLRLLEDARDGLRRELLEAQ 1181
Query: 982 DLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK 1041
L++ E R+ + Q A R+ L + E L +E + + +E+ER ++
Sbjct: 1182 RKLRESQEGREVQRQEAGELRRSLGEGAKE-REALRRSNEELRSAVKKAESERISLKLAN 1240
Query: 1042 ENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTL 1101
E+KE + +E + + E LQ + + +L A + Q L +QM L
Sbjct: 1241 EDKEQK----LALLEEARTAVGKEAGELRTGLQEVERS---RLEARRELQELRRQMKM-L 1292
Query: 1102 QDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPE 1161
+ ++ AE+ A+ ++ + + G L+K S E + E
Sbjct: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEA--------SLEVMRQE 1344
Query: 1162 LE---EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQ 1218
L+ K+ E E +++L +L + K+ + R L +L+ + + L +
Sbjct: 1345 LQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLR 1404
Query: 1219 FDEQSKENENIGDQLRQLQIQVRESID---------------GKLPSTDQQESCSSTPGL 1263
+ + +L ++++Q R + G+ PS + S P
Sbjct: 1405 LSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGS-PAR 1463
Query: 1264 EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELEL 1323
+ P + E ++ LE + PS S ++ L+E
Sbjct: 1464 DAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREF--------- 1514
Query: 1324 KVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG 1383
EL E +L+ Q + ++ ++ A A LQ+ + S+
Sbjct: 1515 -----LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE----- 1564
Query: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443
E R + +L +Q ++ +EE V + SE+E T Q +E+ ++A ++L
Sbjct: 1565 -EARRSVDGRLSGVQAELALQEESV-----RRSERERRATLDQVATLERS--LQATESEL 1616
Query: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEI---GEESRAKQQIQRK-----LQAALISRKEA 1495
++E ++K + +L K++ +E+ E K ++QR+ LQ + + +
Sbjct: 1617 RA-SQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDR 1675
Query: 1496 LKENKSLQEEL-SLARG-------------TIERLTKSLADVESQVSAQNKEKDTVLGRL 1541
+ ++LQ+ + SL R T+ERL +LA VE A +D V G
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL---RDKVRGLT 1732
Query: 1542 ALLQEERDKLITEMDRSLL----------ENQSLSSSCESLKLALEGLTEDKEKLVKEIE 1591
L + L + D++L + Q L ++ + AL + L ++++
Sbjct: 1733 EALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQ 1792
Query: 1592 SLKSSKIAESTEWQEKHKELQKEYEILLQSYENVS---NEAERIQHVVEAVRQEKQELYG 1648
+L+ + E +LQ+ E+L Q E + N +++Q +++ L
Sbjct: 1793 TLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQR 1852
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
L EA K+E E+ E++ ++ + K + K L E+ RL AE
Sbjct: 1853 ALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREK----LRSHEDTVRLSAEKGRLDR 1908
Query: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVS 1768
T L A + ++++++ + L + E D+ +++ +L+ ++E S
Sbjct: 1909 TLTGAELEL----AEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVERLRS 1963
Query: 1769 KQA----NLEATEK-HDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK 1819
QA LEA E+ H + EE ++ G+ +++ L S+ P S P K
Sbjct: 1964 AQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQE--LRRSSAPFSPPSGPPEK 2017
Score = 156 bits (394), Expect = 4e-37
Identities = 306/1413 (21%), Positives = 599/1413 (42%), Gaps = 197/1413 (13%)
Query: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL-------EERLMNQL 1930
+T+ L LQEE NQ +Q+ELSRV L + E+D+L ERL L
Sbjct: 70 ATEMASLLSLQEE-------NQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQAL 122
Query: 1931 AELNGSI------GNYCQDVTDAQIKNELLESEMKNLKK--CVSELEEEKQQLVK----- 1977
G + G Q V +++ +L E + +K E ++ + QLV+
Sbjct: 123 RLEPGELETQEPRGLVRQSV---ELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGK 179
Query: 1978 --EKTKVESEIRKEYLEKI-QGAQKEPGNKSHAKELQELL---KEKQQEVKQLQKDCIRY 2031
+ K SE+ ++ LE+ + Q+ + H+++L+ L +E+QQ L +
Sbjct: 180 ILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAML 239
Query: 2032 QEKIS-------ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
+E++ AL ++ + T +K+LE +E + E A ++LL
Sbjct: 240 REQLDQAGSANQALSEDIRKVTNDWTRCRKELE-HREAAWRREEESFNAYFSNEHSRLLL 298
Query: 2085 DDTQSEAARVLADNLKLKKE---LQSNKESVKSQMKQKDEDLE-----RRLEQAEEKHLK 2136
Q R L +K+ E LQ E ++ ++ L R E E L+
Sbjct: 299 LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALE 358
Query: 2137 EKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST-----VTQLAAFT 2191
++ +Q +L+ R+KV L +KD QQ+Q +LD VT+L
Sbjct: 359 KQALLQAQLEEQLRDKV------------LREKDLAQQQMQSDLDKADLSARVTELGLAV 406
Query: 2192 KSMSSLQDDRDRVI-DEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL 2250
K + ++D+V D +K E S +Q E+ L+ ++ L+ LR ++
Sbjct: 407 KRLEKQNLEKDQVNKDLTEKLEALESLRLQ---EQAALETEDGEGLQQTLRDLA------ 457
Query: 2251 KINISRLEHDKQIWESKAQTEVQLQ--QKVCDTLQGENKELLSQLEETRHLYHS------ 2302
Q S +++ VQL ++ D G + L Q + S
Sbjct: 458 -----------QAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRS 506
Query: 2303 ----------SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS 2352
+ LA + S L + Q+ D+ E ++ L G +R+Q +D ++
Sbjct: 507 PRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQD----LLGTLRKQLSDSESE 562
Query: 2353 KFSYEQLETDLQASRELTSRLHEEINMKEQKIIS---LLSGKEEAIQVAIAELRQQHDKE 2409
+ + E+ L+ + + HE+ + Q++ S LLS ++ + ++ +QQ ++
Sbjct: 563 RRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEEL 622
Query: 2410 IKELENLLSQEEE---ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
+E E L + +EE + LEEE + AV ++ L+ ++ Q + + K +
Sbjct: 623 RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL 682
Query: 2467 SSLQN--DRDRIVGDYQQLEERHLSIILEKDQLIQ-EAAAENNKLKEEIRGLRSHMDDLN 2523
++ R + D Q E+ ++ L K + + E KL+ E L+ + L+
Sbjct: 683 VEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLS 742
Query: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKEL---ENKYAKLEEKLKESE 2580
+ L+ L Q + DLN+++ + ++ L Q Q +E + +LEE E E
Sbjct: 743 A----LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE 798
Query: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
A + L S ++ ++ L +++ +L+ SQL Q+ L + + G + + E
Sbjct: 799 VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS-GREQELEQARREA 857
Query: 2641 VHRLSALFSSSQKRIAELEEEL-VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699
++ AL +++++ A +E + VQ AA++ G L +E L + +
Sbjct: 858 QRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRT---LSEEATRLRLEKEALEGSLF 914
Query: 2700 TAEERVAELA--RDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS----RDHANEE 2753
+ ++A+L R+ +E E + L++ KE LT ++ + + + Q ++ ++
Sbjct: 915 EVQRQLAQLEARREQLEAEGQALLLAKET--LTGELAGLRQQIIATQEKASLDKELMAQK 972
Query: 2754 LDELKRKYDASLKELAQLKEQGL--LNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
L + +R+ ASL+E E+ L L RE++A E + +L QL
Sbjct: 973 LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELE-----------AERAQLQSQLQ 1021
Query: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDH--LWNELEKFRKSEEGKQRSAAQP 2869
+ E+LL ++LE + + S+ +A+LQ ERD L E EK ++ ++
Sbjct: 1022 REQEELL---ARLEA---EKEELSEEIAALQQERDEGLLLAESEK----QQALSLKESEK 1071
Query: 2870 STSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQ-INQEITELHPLKAQLQEYQDKT 2928
+ ++ + +++++ + +R ++ ++ Q+Q +N +EL L+AQ +E
Sbjct: 1072 TALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE----- 1126
Query: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI 2988
A +E+R+ Q + L ++ S ++ Q + +D L
Sbjct: 1127 -AAAAHAQEVRR----LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQ 1181
Query: 2989 RELRSSSSQTQPLKVQYQRQASPETSAS-PDGSQNLVYETELLRT---QLNDSLKEIHQK 3044
R+LR S + QRQ + E S +G++ E E LR +L ++K+ +
Sbjct: 1182 RKLRESQEGRE-----VQRQEAGELRRSLGEGAK----EREALRRSNEELRSAVKKAESE 1232
Query: 3045 ELRIQQLNSNFSQ---LLEEKNT-LSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQEL 3100
+ ++ N + Q LLEE T + + + L+E ++ + L +Q++ L
Sbjct: 1233 RISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKML 1292
Query: 3101 QAGPLNIDVAPGAPQEKNGVHRKSDPEELREP---QQSFSEAQQQLCNTRQEVNELRKLL 3157
+ + Q + + +++ E RE +Q + + L RQE+ ++ L
Sbjct: 1293 DSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL 1352
Query: 3158 EEERDQRVAAENALSVAEEQIRRLEHSEWDSSR 3190
+E+ + E L + E+ R E + D +R
Sbjct: 1353 QEQEGEFRTRERRLLGSLEEARGTEKQQLDHAR 1385
Score = 96.7 bits (239), Expect = 3e-19
Identities = 187/914 (20%), Positives = 361/914 (39%), Gaps = 112/914 (12%)
Query: 2324 LSNSLEKCKEQKGNLEGIIRQQEADI--QNSKFSYEQLETDLQAS------RELTSRLHE 2375
+S L + +E + LE +I+ E+ + Q L D Q + RE+ +R
Sbjct: 1 MSLGLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTR--- 57
Query: 2376 EINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV 2435
N+ + + LL E A +++ E Q +E+ +E+LL+Q E L +
Sbjct: 58 --NLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVS 115
Query: 2436 DKTNQLMET----LKT-----IKKENIQQKAQLD----SFVKSMSSLQNDRDRIVGDYQQ 2482
++ Q + L+T + +++++ + QL S+ + + + Q + R Q+
Sbjct: 116 ERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR 175
Query: 2483 LEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQ 2542
L+ + L +L Q+ + +L+++ H DL S +L+ E Q L Q
Sbjct: 176 LQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQ-QRSASLAQ 234
Query: 2543 VITIKDSQQKQLLEVQLQQNKELE---NKYAKLEEKLKESEEANEDLRRSFNALQEEKQD 2599
V + Q Q ++++ N + + ++L+ E A SFNA +
Sbjct: 235 VNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294
Query: 2600 ----LSKEIESLKVSISQ---------------LTRQVTALQEEGTLGLYHAQLKVKEEE 2640
L +++ + +S+ L R A+QE G LGL L++ E
Sbjct: 295 RLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAG-LGL-STGLRLAES- 351
Query: 2641 VHRLSALFSSSQKRIAELEEEL---VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNE 2697
R A A+LEE+L V +K+ A++ + D K +L + G+
Sbjct: 352 --RAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQ-SDLDKADLSARVTELGLAVKR 408
Query: 2698 TETAEERVAELARDLVE---------MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748
E ++ +DL E ++++ + T++ +GL ++ +++ S S
Sbjct: 409 LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSES-- 466
Query: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEE--NSLSHLEKL 2806
+L +R DAS L L Q + R + + S L +
Sbjct: 467 --GVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALI 524
Query: 2807 NQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSA 2866
+ L + Q+ + + E S + + + K ++ ++ER L +L++ R +G ++
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH 584
Query: 2867 AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQD 2926
+ EVQ L+ A L ++ L L+ QQQ ++ QE +L + +L+ +D
Sbjct: 585 ED---AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRD 641
Query: 2927 KTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQN 2986
+ + QE+ Q+ + EL E+S ++ + K L L
Sbjct: 642 R---LEEEQEDAVQDGARVRREL-----ERSHRQLEQLEGKRSVL---------AKELVE 684
Query: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
+ L ++ Q L+ + A T A E EL T+L +
Sbjct: 685 VREALSRATLQRDMLQAEKAEVAEALTKAEAGR-----VELELSMTKLRAEEASLQDSLS 739
Query: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLN 3106
++ LN + +Q + N L QL + +L+ Q+ V ++ + L+ L
Sbjct: 740 KLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR---QAEQEATVAREEQERLEELRLE 796
Query: 3107 IDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVA 3166
+VA R+ LR +Q+ +QQL R E ++L++ L + Q
Sbjct: 797 QEVA-----------RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSG 845
Query: 3167 AENALSVAEEQIRR 3180
E L A + +R
Sbjct: 846 REQELEQARREAQR 859
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 220 bits (561), Expect = 2e-56
Identities = 271/1341 (20%), Positives = 574/1341 (42%), Gaps = 170/1341 (12%)
Query: 1291 HSEDASALQGGTSVAQIKAQ---LKEIEAEKVELELKVSSTTSELTKKSEEVFQ-LQEQ- 1345
H + GG S +K L E + ++ LK SE KK E +Q LQ+Q
Sbjct: 64 HDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQE 123
Query: 1346 ------INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLRELQPKLDELQ 1398
+ E++SL+ EA+ +++Q + + + A L + +++ K DE +
Sbjct: 124 AKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEER 183
Query: 1399 KLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
L E+ V+ L+ +L+++ + ++TE++++ + + E+ +Q
Sbjct: 184 SLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKEL-----------VQ 232
Query: 1459 VELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTK 1518
V+ E E + K + +KLQ+ S + + + L+ EL+ + +
Sbjct: 233 VQTLMDNMTLERERESEKLKDEC-KKLQSQYASSEATISQ---LRSELAKGPQEVAVYVQ 288
Query: 1519 SLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEG 1578
L ++S V+ ++ T+ L +++ KL + + + +++ ++ L
Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL---- 344
Query: 1579 LTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ---SYENVSNEAERIQHV 1635
D ++L + + ++S E EK + QK E L + Y+++ E +++Q
Sbjct: 345 ---DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ 401
Query: 1636 VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695
E Q +L ++ + ETE+QL EA ++E ++ + K+Q++ +L+ +
Sbjct: 402 REEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLK 461
Query: 1696 NDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEE 1755
RL +E ++ ++++ ++ +L++ K +++ QS ++ +
Sbjct: 462 LSRL-----------EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
Query: 1756 VQDLKHQIEGNVSKQANLEAT-------------EKHDNQTNVTE-EGTQSIPGETEEQD 1801
++ + QI K NLEA E+ D + EG ++ + +E++
Sbjct: 511 LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKN 570
Query: 1802 SLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE-------- 1853
+E + + ++ ++ HD++ + ++R+ LE
Sbjct: 571 HTLQEQVTQLTEKLKNQSESHKQAQENL--HDQVQEQKAHLRAAQDRVLSLETSVNELNS 628
Query: 1854 ---EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910
E K+K + ++ + LLS + K + LQ + Q Q+EL+++T
Sbjct: 629 QLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
+ + D +E ++L + Y + + K E LE ++K L+ E++
Sbjct: 689 QLDQVTAKLQDKQEHC----SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 1971 EKQQLVKE-----KTKVESEIRKEYLEKIQGAQKEPGN--------KSHAKELQELLKEK 2017
K+Q +++ + + E+R L K +KE + KS A E + K
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804
Query: 2018 QQEVKQL---------QKDCIRYQEKISALERTVKALEFVQTESQK---DLEITKENLAQ 2065
Q+E KQ+ Q+ I+++E + ++ TV L+ V+ E + +L K+ L++
Sbjct: 805 QEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 864
Query: 2066 AVEHRKKAQAELA---------------SFKVLLDDTQSEAARVLADNLKLKKELQSNKE 2110
+ K +++E + K L Q + L + +LKK L+ KE
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Query: 2111 SVKSQMKQKDEDLERRLEQAE---EKHLKEKKNMQEKLDALRR----EKVHLEETIGEIQ 2163
+ Q+K + ++ +L QA+ +++ KE++ +Q ++ L++ +K +E GE++
Sbjct: 925 A-SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 2164 VTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKF-------- 2215
+ + +K + +LQ+ L +LAA + +S LQ++ ++ + K+ + F
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
Query: 2216 --SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQ 2273
++S EE++ L +++ ++Q+ + ++ELK + LE D E + Q +
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 2274 LQQKVCDTLQGENKELL---SQLEETRHLYHSSQNELAKLESELKSLK----DQLTDLSN 2326
Q + + KEL+ S+L E + + E+ KL ELKS K ++T+L +
Sbjct: 1104 ALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD 1163
Query: 2327 SLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR--------ELTSRLHEEIN 2378
+ + +QK L+G +A ++ K + + L+ ++ E ++LH EI
Sbjct: 1164 AKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIK 1223
Query: 2379 MK----------EQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE 2428
K E K+ ++ E + E Q + + ELE E VLE
Sbjct: 1224 EKEVGMKKHEENEAKLTMQITALNENLGTVKKEW-QSSQRRVSELEKQTDDLRGEIAVLE 1282
Query: 2429 EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHL 2488
+ D+ L+E + +K E +K Q + LQ D Q+L +
Sbjct: 1283 ATVQNNQDERRALLE--RCLKGEGEIEKLQ-----TKVLELQRKLDNTTAAVQELGRENQ 1335
Query: 2489 SIILEKDQLIQEAAAENNKLK 2509
S+ ++ Q + AE+N+++
Sbjct: 1336 SLQIKHTQALNRKWAEDNEVQ 1356
Score = 215 bits (547), Expect = 7e-55
Identities = 289/1311 (22%), Positives = 564/1311 (43%), Gaps = 161/1311 (12%)
Query: 1636 VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695
V +RQE Q+L L+ + +E +K+L E Q +++ + K ++ LE++
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKEL-EKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
Query: 1696 NDRLRAE---VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSL 1752
+ + E + D ++ L + A +K + + + E +K L E +
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 1753 SEEVQDLKHQI-------EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805
+ +QDLK ++ + V K+ ++ DN T E ++ + E ++ S
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
Query: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865
S+ T S+ + S + P E+ Y+Q++ +LK + L ++ Q E
Sbjct: 264 SSEATISQ-LRSELAKGP---------QEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
Query: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
E + L + + + K +Q + + +L QQ+Q LS ET+ R
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA----SETSLH-------R 362
Query: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE 1985
+ +L+E + +++++ + K + L++E K L++ E E+ QL E ++ S+
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 1986 I--RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043
+ + L + G KE S K L +K+Q+V LQ K+S LE +K
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEK-----LMDKEQQVADLQL-------KLSRLEEQLK 470
Query: 2044 ALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK--- 2100
TE Q L+ TK+ Q E + Q+ A + +D + ++ + K
Sbjct: 471 EKVTNSTELQHQLDKTKQ---QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527
Query: 2101 LKKELQSNKESVK-----------------------SQMKQKDEDLERRLEQAEEK---H 2134
L+ LQ +KE++ +Q+++K+ L+ ++ Q EK
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
Query: 2135 LKEKKNMQEKL-DALRREKVHL----------EETIGEIQVTLNKKDKEVQQLQENLDST 2183
+ K QE L D ++ +K HL E ++ E+ LN+ ++V QL + +
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
Query: 2184 VTQL----AAFTKSMSSLQDDRD---RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
L AA T + LQ+ D + + ++ K + + +++ K+++CS L
Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 2237 KDQLRQ-------MSIHMEELKINISRLEHDK-QIWESKAQT--EVQLQQKVCDTLQGEN 2286
+ L++ + EEL+ I +LE D ++ SK Q ++Q Q+++ L+
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLT-----------DLSNSLEKCKEQK 2335
EL QLE + + S++ +L K L+S+K +LT D ++ K Q
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHE-------EINMKEQKIISLL 2388
L I+ ++Q K E L T+L ++ S++ + E + QK + +
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 2389 SGKEEAIQVAIAELRQQHD---KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETL 2445
E+ + +L+ Q + KE KEL+ L +E+E + L+ E ++ Q TL
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 2446 KTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ----QLEERHLSIILEKDQLIQEA 2501
K +KE Q + ++ +S + + + G+ + Q E + + Q QE
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 2502 AAENNK---LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQ 2558
AAE K L+ + L S+ ++EL+ R+DL V Q+ L+ +
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 2559 LQ---QNK---ELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSIS 2612
Q QNK EL+ A LE+ + E+ ++ ++ +Q+EK KE+ + K ++
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 2613 QLTRQVTALQEEGTLGLYHAQLKVKEE-EVHRLSALFSSSQKRIAELEEELVCVQKEAAK 2671
++ ++E T K+ EE + H+L ++ K I L++ + ++ +
Sbjct: 1128 EIEEIKCRQEKEIT--------KLNEELKSHKLESI-----KEITNLKDAKQLLIQQKLE 1174
Query: 2672 KVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTA 2731
G+ D LK ++ + I++++ + EE EL ++ +E E KL KE +
Sbjct: 1175 LQGK-ADSLKAAVEQEKRNQQILKDQVKKEEE---ELKKEFIEKEAKLHSEIKEKE---V 1227
Query: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
++ + + L NE L +K+++ +S + +++L++Q R A+L T +
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQ 2842
L K ++ ++L L +L+++ VQ + SLQ
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 201 bits (511), Expect = 1e-50
Identities = 320/1515 (21%), Positives = 638/1515 (42%), Gaps = 246/1515 (16%)
Query: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
LQ+ + ++ L S+ + + NE S + G AD V
Sbjct: 6 LQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHD 65
Query: 533 ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL---QGKRAEEA- 588
A S ES + + + +E+ L +KE + LK +L QG + +EA
Sbjct: 66 AGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK 125
Query: 589 -DHEVLD--------QKEMKQMEGEGIAPIKMKVFLEDTG-------QDFPLMPNEESSL 632
D V D ++++++ + E +MK E D +EE SL
Sbjct: 126 PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL 185
Query: 633 PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692
+A+ + +R +EE++ + QD L P I +++ LK +
Sbjct: 186 -----REAAEQKVTRLTEELNKEATVI------QDLKTELLQRPGI-----EDVAVLKKE 229
Query: 693 ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752
++++ Q + + E+ +E L +E KK +S+ +S+ R +L
Sbjct: 230 LVQV-------QTLMDNMTLERERESEKLK---DECKKLQSQYASSEATISQLRSELAKG 279
Query: 753 VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAK------ 806
+E+++ + ++++L+ ++ E L ++QT +NLL ++ +E K
Sbjct: 280 PQEVAVYVQ---ELQKLKSSVNE------LTQKNQTLTENLLKKEQDYTKLEEKHNEESV 330
Query: 807 -SKDVKIEVLQNELDDVQLQ--FSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
K+++ + Q +LD QLQ S T + + +L K + E + + +K +
Sbjct: 331 SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH 390
Query: 864 LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923
L Q + + + +Q L+ + ++ L + E ++Q+ E + E+ QL+ EK
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR-QLSSEKL- 448
Query: 924 LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983
+ E + QL LSR EE KE+V + ELQH+ D
Sbjct: 449 MDKEQQVADLQLK-LSRLEEQLKEKV----------------------TNSTELQHQLDK 485
Query: 984 LKKENEQRK-------RKLQAALINRKELLQRVSRLEEELANLK---DESKKEIPLSETE 1033
K+++++++ KL+ A + +++L+++ ++++ NL+ +SK+ I L E E
Sbjct: 486 TKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Query: 1034 RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL-QHIRKDLEEKLAAEEQFQA 1092
R ++ + E E V ++ QE T+ E+ +L + ++ E A+E
Sbjct: 546 REDLYAKIQAGE-GETAVLNQLQE----KNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152
V++ L+ +++ L+ ++E + +L S S D K +++S
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNE---LNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH---LREELKQQK 1209
+++ + +L+ + + + Q++L + T + K Q+K+ H L LK+ K
Sbjct: 658 KTAQ--RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK 715
Query: 1210 DDYNRLQEQFDEQSKENENIGDQLRQLQ---IQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
+ Y L++ + E + Q+++L+ ++V+ S + L QQ ++ L
Sbjct: 716 EKYLSLEQ-------KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL--- 765
Query: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326
+ATE K++E EK E+ VS
Sbjct: 766 --RATELS-------------------------------------KQLEMEK-EI---VS 782
Query: 1327 STTSELTKKSEEVFQLQEQINKQGLEIESLK----TVSHEAEVHAESLQQKLESSQLQIA 1382
ST +L KKSE + +++++ KQ E + LK T+S E ++ E L +++++
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT----- 837
Query: 1383 GLEHLRELQPKLDELQKLISKKE---EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL 1439
+ ELQK+ +KE ++S + +LS+ +L ++E ++ KA
Sbjct: 838 -----------VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
Query: 1440 HTQLEMQAKEHDERIK-QLQVELCEMKQKPEEIGEESRAKQQIQRKL---QAALISRKEA 1495
LE KE +++ Q++ L E K+ + + +E A Q++ +L Q LI +
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Query: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
LK+N+ +++L +G I L +S + Q+ A E ++A+LQ+ TE+
Sbjct: 947 LKQNEKEEQQL---QGNINELKQSSEQKKKQIEALQGEL-----KIAVLQK------TEL 992
Query: 1556 DRSLLENQSLSSSCESL---KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
+ L Q L+ + + L K + L + EK + + L+S +E ++L+
Sbjct: 993 ENKL--QQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE---AEQ 1669
E L + E++ + +I + + + QEL + E + + E+QLQE A Q
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLI----QELKTAKATLEQDSAKKEQQLQERCKALQ 1106
Query: 1670 EMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE 1729
++++ K K +++ K+ E+EE R E+ + K + ++K+ +
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ 1166
Query: 1730 RVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEG 1789
+ + L K SL + + Q LK Q++ ++ E EK + +E
Sbjct: 1167 LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK-KEEEELKKEFIEKEAKLHSEIKEK 1225
Query: 1790 TQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF-SSHDEINNYLQQIDQLKER 1848
+ E + L+M + + V K++ SS ++ +Q D L+
Sbjct: 1226 EVGMKKHEENEAKLTM--------QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGE 1277
Query: 1849 IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908
IA LE Q N ++E+ LL + +GE++ LQ +V ++Q +L
Sbjct: 1278 IAVLEATVQNN-------QDERRALLERCLKGEGEIEKLQTKVL-------ELQRKLDNT 1323
Query: 1909 TKLKETAEEEKDDLE 1923
T + E L+
Sbjct: 1324 TAAVQELGRENQSLQ 1338
Score = 194 bits (493), Expect = 1e-48
Identities = 259/1306 (19%), Positives = 582/1306 (44%), Gaps = 143/1306 (10%)
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE--ERLMNQLAELNGSIG 1938
+ L + +++VT LL Q++Q+ + + + K +EE K +LE + L Q A+ +G +
Sbjct: 75 ESNLALKRDDVT---LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT 131
Query: 1939 NYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQ 1998
+ ++ + + E ++E N+K+ E++ QL E ++S+ +E + Q
Sbjct: 132 DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191
Query: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ--EKISALERTVKALEFVQTESQKD- 2055
K L E L ++ ++ L+ + ++ E ++ L++ E VQ ++ D
Sbjct: 192 K-------VTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK-----ELVQVQTLMDN 239
Query: 2056 LEITKENLAQAVEHR-KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114
+ + +E ++ ++ KK Q++ AS + + +SE A+ + +ELQ K SV +
Sbjct: 240 MTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSV-N 298
Query: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGE--IQVTLNKKDKE 2172
++ QK++ L L + E+ + K ++EK H EE++ + IQ TL++KD +
Sbjct: 299 ELTQKNQTLTENLLKKEQDYTK----LEEK---------HNEESVSKKNIQATLHQKDLD 345
Query: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDA------IQSKEEEI 2226
QQLQ L ++ T L +S + ++ +E + E K+ +Q + EE
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE- 404
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINIS----RLEHDKQIWESKAQTEVQ----LQQKV 2278
KE + L+ ++ Q+ + E + + RL+ +Q+ K + Q LQ K+
Sbjct: 405 --KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
Query: 2279 CDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338
L+ + KE ++ E +H ++ + + ++ +S +L + N LE+ Q G+
Sbjct: 463 -SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
Query: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
+ I+ EA +Q SK + LE + + +L +++ + E +++ L K +Q
Sbjct: 522 DQKIQNLEALLQKSKENISLLEKERE---DLYAKI--QAGEGETAVLNQLQEKNHTLQEQ 576
Query: 2399 IAEL----RQQHDKEIKELENLLSQEEEENIVLEEENKKAV-------DKTNQLMETLKT 2447
+ +L + Q + + ENL Q +E+ L + + + +QL E+ +
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
Query: 2448 IKKENIQQKAQLDSFVKSMSS-------LQNDRDRIVGDYQQLEERHLSIILEKDQL--- 2497
+ + +IQ KA+ + + + ++ LQN D Q ++ I + DQ+
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696
Query: 2498 IQEAAAENNKL-------KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQ 2550
+Q+ ++L KE+ L ++L + KL+A+ ++ + Q + +D Q
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL--QDLQ 754
Query: 2551 QKQLLEVQLQQNKELENKYAKLEEK--------LKESEEANEDLRRSFNALQEEKQDLSK 2602
Q++ L L+ +K ++E++ L++ EA E +++ +EEKQ L +
Sbjct: 755 QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ 814
Query: 2603 EIESL----KVSISQLTRQ----VTALQE-EGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
+ E+L K+ +L + VT LQ+ + +L ++++ ++S +S+
Sbjct: 815 DFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
Query: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLV 2713
+ ++ + K E++ +L+ ++++ + ++ E +E +L +L
Sbjct: 875 EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
Query: 2714 EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK- 2772
M+++L+ K + Q +++ L+ S + ++++ L+ + ++ + +L+
Sbjct: 935 SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Query: 2773 --EQGLLNRERDALLSETAFS-MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN 2829
+Q L ++ + S + + E S ++L ++ +LL + +D +
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL---ATRQDLKS 1051
Query: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889
+ S A L + R+ + N+ + ++ + K + ++Q KA+ +Q +
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111
Query: 2890 RDRLLKELKNLQQQYLQINQ-------EITELH-PLKAQLQEYQDKTKAFQIMQEELRQE 2941
+ KEL N + + +I + EIT+L+ LK+ E + + ++ L Q+
Sbjct: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001
L Q + L+ + +++ +K+Q + ++++L + I + S+ +
Sbjct: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQ----VKKEEEELK--KEFIEKEAKLHSEIKEK 1225
Query: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEE 3061
+V ++ E L + L L KE + R+ S+L ++
Sbjct: 1226 EVGMKKHEENEA--------KLTMQITALNENLGTVKKEWQSSQRRV-------SELEKQ 1270
Query: 3062 KNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107
+ L ++ +++ NQ LL C E ++++LQ L +
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL 1316
Score = 190 bits (483), Expect = 2e-47
Identities = 296/1428 (20%), Positives = 599/1428 (41%), Gaps = 204/1428 (14%)
Query: 160 ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVV 219
+ LQA L + + + E+E++ ++QQ + + ++ A+L + + Q
Sbjct: 92 VQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQT- 149
Query: 220 REKDARFETQVRLHEDELLQLVTQ-ADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLL 278
++ + L E + QL T+ AD++++ + +R L E E V R L
Sbjct: 150 --ENFNIKQMKDLFEQKAAQLATEIADIKSKYDE-----ERSLREAAEQKVTR------L 196
Query: 279 QQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338
+EL Q L +L Q + ++ E + + L++ M LE R+ L
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVA--VLKKELVQVQTLMDNMTLE---RERESEKL 251
Query: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL 398
++E L Q+ + ++L S + Q+ ++E S+ + Q+ Q+ + L
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL 311
Query: 399 --KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD 456
K+Q+ L++K+ + S + IQ L QK + Q +RL +AS+TS
Sbjct: 312 LKKEQDYTKLEEKHNEESVSKKNIQAT---LHQKDLDCQQLQSRL------SASETSLHR 362
Query: 457 VYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEK----LSSQIT--- 509
++ E ++ E L++ + E+E + L +L++ + E E+ L S+I
Sbjct: 363 IHVELSEK--GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 510 --LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567
LLE + + GEA + E +R S+E+ K ++++ L L++
Sbjct: 421 SKLLETERQLGEAHGRLKE--------QRQLSSEK---------LMDKEQQVADLQLKLS 463
Query: 568 EAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627
+E+ L+ + + E H+ LD+ + + E + +
Sbjct: 464 RLEEQ-----LKEKVTNSTELQHQ-LDKTKQQHQEQQAL--------------------- 496
Query: 628 EESSLPAVEKEQASTEHQSRTSEEISLNDAGVE-LKSTKQDGDKSLSAVPDIGQCHQDEL 686
++S+ + + Q E R +I D ++ L++ Q +++S + + E
Sbjct: 497 QQSTTAKLREAQNDLEQVLR---QIGDKDQKIQNLEALLQKSKENISLL-------EKER 546
Query: 687 ERLKSQILELELNFHKAQEIYEKN--LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSE 744
E L ++I E ++ EKN L E+ + QL E+ K ++++ A L +
Sbjct: 547 EDLYAKIQAGEGETAVLNQLQEKNHTLQEQ------VTQLTEKLKNQSESHKQAQENLHD 600
Query: 745 ERDQLLSQVKELS-MVTELRAQVKQLEMNLAEA-ERQRRLDYESQTAHDNLLTEQIHSLS 802
+ + + ++ V L V +L L E+ E+ +LD + + + LL+ + +
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 803 IEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
A ++ ++ QN L D Q + ++ +T + + ++LQ+K+ + ++ K
Sbjct: 661 QRADLQN-HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
L Q + E +I K++ LE K E Q ++++ Q T++ TE QL EK
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ + + L S A E+ K+++ + E LKQ+++ +S +I EEL +
Sbjct: 780 I----VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 983 LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKE 1042
E ++ K + +A L EL+ +KD+ K + + E E++ +
Sbjct: 836 TTVTELQKVKMEKEA--------------LMTELSTVKDKLSKVSDSLKNSKSEFEKENQ 881
Query: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ 1102
+ + + C+E++ L+ + E + ++K LE++ A Q + + M + L
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941
Query: 1103 DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162
N + + E + Q I +L SSE K ++
Sbjct: 942 QAQNTLKQNEKEEQQLQGNINEL--------------------------KQSSEQKKKQI 975
Query: 1163 EE-----KILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE 1217
E KI L +K +L+ KLQ+ LT L +EK L+ ++ ++ + +LQ
Sbjct: 976 EALQGELKIAVL--QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 1218 QFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQ 1277
F +E+E + + Q +S++ KL S Q++ S+ + E +
Sbjct: 1034 DF--YGRESELLATR------QDLKSVEEKL-SLAQEDLISNRNQIGNQNKLIQELKTAK 1084
Query: 1278 PVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSE 1337
LE + E ALQ I+ + E E V + K++ ++ +
Sbjct: 1085 ATLEQDSAKKEQQLQERCKALQ------DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 1338 EVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDEL 1397
E+ +L E++ ++ES+K +++ + +QQKL ELQ K D L
Sbjct: 1139 EITKLNEELKSH--KLESIKEITNLKDAKQLLIQQKL--------------ELQGKADSL 1182
Query: 1398 QKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQL 1457
+ + +++ + L Q+ ++E L K E IE+E + + + E+ K+H+E +L
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEEELKK---EFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239
Query: 1458 QVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517
+++ + E +G + Q QR++ E K+ L+ E+++ T++
Sbjct: 1240 TMQITALN---ENLGTVKKEWQSSQRRV-------SELEKQTDDLRGEIAVLEATVQNNQ 1289
Query: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565
+ + E + + ++ LQ + D + ENQSL
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1337
Score = 170 bits (431), Expect = 2e-41
Identities = 247/1190 (20%), Positives = 511/1190 (42%), Gaps = 193/1190 (16%)
Query: 2004 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENL 2063
+ ++LQ LKE++ ++L+K+ +YQ L++ + + T+S +L+ +L
Sbjct: 89 RQEVQDLQASLKEEKWYSEELKKELEKYQ----GLQQQEAKPDGLVTDSSAELQ----SL 140
Query: 2064 AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDL 2123
Q +E + + K L + ++ A +AD E +S +E+ + ++ + E+L
Sbjct: 141 EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200
Query: 2124 --ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181
E + Q + L ++ +++ + L++E V ++ + + + ++++E ++L++
Sbjct: 201 NKEATVIQDLKTELLQRPGIED-VAVLKKELVQVQTLMDNMTL---ERERESEKLKDECK 256
Query: 2182 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR 2241
+Q A+ ++S L+ + + +E+ + LK +
Sbjct: 257 KLQSQYASSEATISQLRSE------------------LAKGPQEVAVYVQELQKLKSSVN 298
Query: 2242 QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYH 2301
+++ + L N+ + E D E K E ++ + TL K+L Q
Sbjct: 299 ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH--QKDLDCQ--------- 347
Query: 2302 SSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361
Q+ L+ E+ L + +L++ + +K KE+ + + E Q+ K ++QL+
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEATQKLKEE-------LSEVETKYQHLKAEFKQLQQ 400
Query: 2362 DLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEE 2421
+ + +L EIN K++ EA + E RQ +++ + E ++ +
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEA-HGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 2422 EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQ 2481
+ LEE+ K+ V + +L L K+++ +Q+A S + QND +++
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV----- 514
Query: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541
L I +KDQ IQ A K KE I L REDL
Sbjct: 515 ------LRQIGDKDQKIQNLEALLQKSKENISLLEKE------------------REDLY 550
Query: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN-ALQEEKQDL 2600
I + + L ++Q ++N L+ + +L EKLK E+++ + + + +QE+K L
Sbjct: 551 AKIQAGEGETAVLNQLQ-EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609
Query: 2601 ---SKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
+ SL+ S+++L Q+ +E+ + Q+K K E + LSA + + +R A+
Sbjct: 610 RAAQDRVLSLETSVNELNSQLNESKEK--VSQLDIQIKAKTELL--LSAEAAKTAQR-AD 664
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
L+ L Q ++DK ++EL + + + + +E ++L L E ++
Sbjct: 665 LQNHLDTAQNA-------LQDK-QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
Query: 2718 KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELA-QLKEQGL 2776
K L + ++ + L QI+ ++ S++ A ++L + +R+ + L+ A +L +Q
Sbjct: 717 KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ-QRQLNTDLELRATELSKQLE 775
Query: 2777 LNRERDALLSETAFSMNSTEENSLSHLEKLNQQ-----LLSKDEQLLHLSSQL--EDSYN 2829
+ +E ++S T + E S +KL +Q +L +D + L +++ E+ N
Sbjct: 776 MEKE---IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
Query: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889
++Q+ + ++ E++ L EL + L K SL+N
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVK--------------------DKLSKVSDSLKNS 872
Query: 2890 RDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949
+ KE + + L + + EL K QLQ + T Q+EL++ +
Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKEL---KHQLQVQMENTLK---EQKELKKSLEKEKEAS 926
Query: 2950 HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQA 3009
HQL++E +S + E+ ++ Q + ++K++Q LQ I EL+ SS Q ++Q
Sbjct: 927 HQLKLELNSMQ--EQLIQAQNTLKQNEKEEQ--QLQGNINELKQSSE-------QKKKQI 975
Query: 3010 SPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQL 3069
E Q EL+I L Q E +N L QL
Sbjct: 976 ------------------------------EALQGELKIAVL-----QKTELENKLQQQL 1000
Query: 3070 CDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEEL 3129
+Q L ++ L N+ ++ ++LQ+ + A ++ +L
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ-----------DL 1049
Query: 3130 REPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
+ ++ S AQ+ L + R ++ KL++E + + E + E+Q++
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Score = 169 bits (427), Expect = 5e-41
Identities = 264/1339 (19%), Positives = 551/1339 (41%), Gaps = 204/1339 (15%)
Query: 47 QEDVQERLAYAEQLVVELKD-------------IIRQKDVQLQQKDEALQEERKAADNKI 93
Q ++E Y+E+L EL+ ++ +LQ ++ L EE + + I
Sbjct: 96 QASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL-EEAQTENFNI 154
Query: 94 KKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
K++K + K L I ++K++ +E+++++ + +E I+ +K +L
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214
Query: 154 QEKE--ELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA 211
++ E ++ L+ +L Q Q + E +K + ++ + ++ +A +SQ ++
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274
Query: 212 EQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR 271
E A + +V ++ EL +L + + T+ Q L K E+ L +
Sbjct: 275 ELA----------KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK 324
Query: 272 AQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAER 331
+ ++ + A + + QQLQ + T + + E E +K++ E++E
Sbjct: 325 HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 384
Query: 332 KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391
+ + +L+ E L +Q E+ Q +L+S + L K L +T ++L
Sbjct: 385 ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK--------------LLETERQL 430
Query: 392 QSACDALKDQ---NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
A LK+Q +S+ L DK +Q + +LE+QL++K ++ ++L + +
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH 490
Query: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI 508
Q QA+ + A L++ +LE + +++ L+A +K I
Sbjct: 491 QEQ-----------QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539
Query: 509 TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKE 568
+LLE + A + E G+ + N +K+ L + ++ E
Sbjct: 540 SLLEKEREDLYAKIQAGE-----------------GETAVLNQLQEKNHTLQEQVTQLTE 582
Query: 569 AQEEIAFLKLQLQG-KRAEEADHE-VLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMP 626
LK Q + K+A+E H+ V +QK + + + ++ V
Sbjct: 583 K------LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV------------- 623
Query: 627 NEESSLPAVEKEQAST-EHQSRTSEEISLNDAGVELKSTKQDGD--KSLSAVPDIGQCHQ 683
NE +S KE+ S + Q + E+ L+ E T Q D L + Q Q
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLS---AEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 684 DELERLKSQILELELNFHKAQEI---YEKNLDEKAKEISNLNQLIEEFK---KNADNNSS 737
EL ++ +Q+ ++ QE E +L E ++ +L Q EE + K + +S
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
Query: 738 AFTALSEERDQLLSQVKELSMVTELRAQV--KQLEMNLAEAERQRRLDYES--------- 786
A E+ Q L Q ++L+ ELRA KQLEM E RLD +
Sbjct: 741 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME-KEIVSSTRLDLQKKSEALESIK 799
Query: 787 -----QTAHDNLLTEQIHSLSIEAKSKDVKI------------------EVLQNELDDVQ 823
Q +L + +LS E K + ++ E L EL V+
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 824 LQFSEQSTLIRSLQSQLQNKES-------EVLEGAERVRH---------------ISSKV 861
+ S+ S +++ +S+ + + ++ + + ++H + +
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921
E+ +A Q +LE+ M + L++ + ++ ++ ++ + E+ S +K Q+ +
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA-GQISKEELQHE 980
L + + E N L + +++ + E S L+ NY++ Q+ + E
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 981 FDLLK-----KENEQRKRKLQAALINRKELLQRVSRLEEELANLK-----DESKKEIPLS 1030
+LL K E++ Q LI+ + + ++L +EL K D +KKE L
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Query: 1031 ETERG--EVEEDKENKE---YSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
E + +++++K KE +EK ++ +EI+ ++ I++ EL+ + + +++
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEIT 1159
Query: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL-VKET 1144
+ + L+ Q LQ K + + + NQ I++ + + + + K
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH 1219
Query: 1145 VVISPPCTGSSEHWKPE---------LEEKILALEKEKEQLQKKLQEA----------LT 1185
I G +H + E L E + ++KE + Q+++ E +
Sbjct: 1220 SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIA 1279
Query: 1186 SRKAILKKAQEKERHLRE-------ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238
+A ++ Q++ R L E E+++ + LQ + D + + +G + + LQI
Sbjct: 1280 VLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQI 1339
Query: 1239 QVRESIDGKLPSTDQQESC 1257
+ ++++ K ++ ++C
Sbjct: 1340 KHTQALNRKWAEDNEVQNC 1358
Score = 148 bits (373), Expect = 1e-34
Identities = 209/1016 (20%), Positives = 438/1016 (43%), Gaps = 137/1016 (13%)
Query: 2216 SDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ 2275
+D+ E + LK D+ ++L+ +++ + ++E K L+ + + ++ Q E +
Sbjct: 68 NDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPD 127
Query: 2276 QKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQK 2335
V D+ +EL+SL+ QL + K+ K
Sbjct: 128 GLVTDS-----------------------------SAELQSLEQQLEEAQTENFNIKQMK 158
Query: 2336 GNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAI 2395
E Q +I + K Y++ + +A+ + +RL EE+N KE +I L K E +
Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN-KEATVIQDL--KTELL 215
Query: 2396 QVA----IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451
Q +A L+++ + ++N+ + E E+ L++E KK + T+ ++ E
Sbjct: 216 QRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE 275
Query: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
+ ++ +V+ + L++ + + Q L E +L+K+Q + ++N+
Sbjct: 276 LAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN----LLKKEQDYTKLEEKHNEESVS 331
Query: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571
+ +++ + + + +L + L L+++ V+L + E K
Sbjct: 332 KKNIQATLHQKDLDCQQLQSRLSASETSLHRI------------HVELSEKGEATQK--- 376
Query: 2572 LEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631
L+E+L E E + L+ F LQ+++++ + L+ I+QL ++ L+ E LG H
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL--LETERQLGEAH 434
Query: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVG---EIEDKLKKELKHLH 2688
+LK E+ S ++++A+L+ +L ++++ +KV E++ +L K K H
Sbjct: 435 GRLK---EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT-KQQH 490
Query: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748
+ ++ T TA+ R A+ DL ++ +++ ++ + L A +Q ++S L+ R+
Sbjct: 491 QEQQALQQST-TAKLREAQ--NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547
Query: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQ 2808
+L K A E A L + N +++ + + E+ E L+
Sbjct: 548 -------DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 2809 QLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQ 2868
Q+ EQ HL + +D +++ + S NE ++L+ K++ SA
Sbjct: 601 QV---QEQKAHLRAA-QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928
T+ + LQN D L++ QQ+ +N+ T+L + A+LQ+ Q+
Sbjct: 657 AKTAQR---------ADLQNHLDTAQNALQDKQQE---LNKITTQLDQVTAKLQDKQEHC 704
Query: 2929 KAFQIMQEELRQENLSWQHELHQL-----RMEKSSWEIHERRMKEQYLMAISDKDQ---- 2979
+ +E +++ LS + + +L ++E S E+ + KEQ L + + Q
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV--KASKEQALQDLQQQRQLNTD 762
Query: 2980 ------QLSHLQNLIRELRSS--------SSQTQPLKVQYQRQASPETSASPDGSQNLVY 3025
+LS + +E+ SS S + +K + +Q + D + L
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD-FETLSQ 821
Query: 3026 ETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG- 3084
ET++ +LN+ I +Q++ L+ E +T+ +L S SL+ ++ +
Sbjct: 822 ETKIQHEELNN---RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 3085 ----------DLLNHCAVLEKQVQELQAGPL--NIDVAPGAPQEKNGVHR-----KSDPE 3127
DL C L+ Q+Q L ++ +EK H+ S E
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 3128 ELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEH 3183
+L + Q + + +++ + +NEL++ E+++ Q A + L +A Q LE+
Sbjct: 939 QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Score = 123 bits (309), Expect = 3e-27
Identities = 187/916 (20%), Positives = 384/916 (41%), Gaps = 125/916 (13%)
Query: 12 VLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQK 71
VL ++ D QN+ A L S +E +ED+ ++ E L
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLE---KEREDLYAKIQAGEGETAVLN------ 564
Query: 72 DVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQ 131
QLQ+K+ LQE+ K+K K +L+ ++E KA E
Sbjct: 565 --QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 132 LSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE-----QPAQSSTEMEEFV 186
+++ + E + ++ ++ +++ K EL+ + +A T +A+ AQ++ + ++
Sbjct: 623 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 187 MMK---------QQLQEKEEFISTLQAQLSQTQAEQAA-QQVVREKDARFET------QV 230
+ K +LQ+K+E S L++ L + + + + +Q E + + + +V
Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 231 RLHEDELLQ-LVTQADVETEMQQKLRVLQRKLEEHEE-------SLVGRAQVVDLLQQEL 282
+ +++ LQ L Q + T+++ + L ++LE +E L +++ ++ ++Q+L
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 283 TAAEQRNQILSQQL----QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNL 338
T E+ QIL Q Q+ + +H L N ++T E L+K+++E L
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE----LQKVKMEKEA-------L 851
Query: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL 398
E+ + ++ + + +S + QK KA IL L+KT +EL+
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA-------ILDLEKTCKELKHQLQVQ 904
Query: 399 KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVY 458
+ K ++ + + + QL+ +L +++ Q N L +Q+E Q ++
Sbjct: 905 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL--KQNEKEEQQLQGNI- 961
Query: 459 NEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTG 518
NE Q+ ++ +K++ L+ E +L ELE KL Q+T
Sbjct: 962 NELKQSSEQK-----KKQIEALQGELKIAVLQKTELEN------KLQQQLT-----QAAQ 1005
Query: 519 EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL 578
E E +IS++ N S E Q L++ F + EL ++K +E+++ +
Sbjct: 1006 ELAAEKEKISVLQ--NNYEKSQETFKQ--LQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 579 QLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE 638
L R + + L Q E+K + +D+ + + +L ++KE
Sbjct: 1062 DLISNRNQIGNQNKLIQ-ELKTAKA---------TLEQDSAKKEQQLQERCKALQDIQKE 1111
Query: 639 QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD-ELERLKSQILELE 697
++ LK + +KS A + +C Q+ E+ +L E
Sbjct: 1112 KS--------------------LKEKELVNEKSKLAEIEEIKCRQEKEITKLNE-----E 1146
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757
L HK + I E + AK++ +L E + AD+ +A + L QVK+
Sbjct: 1147 LKSHKLESIKEITNLKDAKQLLIQQKL--ELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 758 MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQN 817
EL+ + + E L +++ + + ++ LT QI +L+ + + + Q
Sbjct: 1205 --EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262
Query: 818 ELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITK 877
+ +++ Q + I L++ +QN + E ER ++E+L + + + ++
Sbjct: 1263 RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDN 1322
Query: 878 MDQLLLEKKRDVETLQ 893
+ E R+ ++LQ
Sbjct: 1323 TTAAVQELGRENQSLQ 1338
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 218 bits (554), Expect = 1e-55
Identities = 647/3338 (19%), Positives = 1330/3338 (39%), Gaps = 486/3338 (14%)
Query: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS 133
+L++++++L+EE+K K K+L+ +++++K +++ + G + S E++S
Sbjct: 1456 RLEEEEKSLEEEKKEHVEKAKELQKW----VSNISKTLKDAEKAGKPPFSKQKISSEEIS 1511
Query: 134 ------------------KH-DKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
KH DK + EE E+EK LQE L+ L Q Q Q
Sbjct: 1512 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL--FSESLKQLQESQ 1569
Query: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA-QQVVREKDARFETQVRLH 233
+ ++EE ++ ++Q QE +E + + L+QT+ Q+ D E +
Sbjct: 1570 TS-GDVKVEEKIVAERQ-QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1627
Query: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
+ E LQ Q + + + ++ + L+E+ E L + L++Q+L A+ + + L+
Sbjct: 1628 KQEELQKDMQGSAQA-LAEVVKNTENFLKENGEKLSQEDKA--LIEQKLNEAKIKCEQLN 1684
Query: 294 QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
+ +Q + E + + T E E ++++E E K NL + + ++ + E+AG
Sbjct: 1685 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLE----ESKTKIENLLDWLSNVDKDSERAG 1740
Query: 354 QAQAELESRYSALEQKHKA-----EMEEKTSHILSLQKTGQ------ELQSACDALKDQN 402
++ + Q+ E +E ++L GQ L +K Q+
Sbjct: 1741 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1800
Query: 403 SKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFL--NRLPLQQH-ETASQTSFPDV 457
K++ A QSAQ + LE Q Q S E + L N L+ H ETA S
Sbjct: 1801 EKIISQHQAVIIATQSAQVL--LEKQGQYLSPEEKEKLQKNMKELKVHYETALAES---- 1854
Query: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
E +T L+K + + L S ELE L+A + ++ +T L+ Q
Sbjct: 1855 --EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1912
Query: 518 GE-ADREVSEISIVDIANKR------SSSAEESGQ--------------DVLENTFSQKH 556
E ++ + I+ R S S + G+ D + F +
Sbjct: 1913 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1972
Query: 557 KELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLE 616
+ +VL +K+ ++ + G A E K + E + P ++ LE
Sbjct: 1973 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPIAVDPKNLQRQLE 2030
Query: 617 DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676
+T ++ + +Q + E +T+E L DA L K D K+L
Sbjct: 2031 ET----------KALQGQISSQQVAVEKLKKTAEV--LLDARGSLLPAKNDIQKTLD--- 2075
Query: 677 DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE--------- 727
DI ++D + + + +L++ ++ + + LDE + N+ ++E
Sbjct: 2076 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQD-GLDEMLDWMGNVESSLKEQGQVPLNST 2134
Query: 728 -----------FKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776
+++ S+ A++E+ + + + + S + L+A++K L +EA
Sbjct: 2135 ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM-ETTDPSTASSLQAKMKDLSARFSEA 2193
Query: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
+ + E+ + L T+ + ++ +E L +V + + + L
Sbjct: 2194 SHKHK---ETLAKMEELKTK-VELFENLSEKLQTFLETKTQALTEVDVPGKD----VTEL 2245
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQ--ALSQKELEITKMDQLLLEKKRDVETLQQ 894
+Q SE LE + + + S ++E+S S K L + K + L + + ++
Sbjct: 2246 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL----SKKFKEMED 2301
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
TI+EK + VT E+ + V +K+LK + E KK + + +
Sbjct: 2302 TIKEKKEAVTSCQ-----------EQLDAFQVLVKSLKSWIK-----ETTKKVPIVQPSF 2345
Query: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
+ L ++ ++ ++LQ ++ L E + K+ + I+ L+ V+ +
Sbjct: 2346 GAEDLGKSLEDT--------KKLQEKWSLKTPEIQ----KVNNSGISLCNLISAVTTPAK 2393
Query: 1015 ELANLKDES---KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
+A +K E + TE + + + ++ +++ + LK I+E
Sbjct: 2394 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT 2453
Query: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMN-----------QTLQDKTNQIDLLQAEISENQA 1120
+L ++K EE A + Q + K + ++ + Q +AE+ +N
Sbjct: 2454 KLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2513
Query: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
+Q+L T+ L++E P T + WK L E I + +E QL
Sbjct: 2514 KVQELKDKLTE--------LLEEN-----PDTPEAPRWKQMLTE-IDSKWQELNQLTIDR 2559
Query: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240
Q+ L L + Q E L++ L +++ + S + + Q +Q+QI +
Sbjct: 2560 QQKLEESSNNLTQFQTVEAQLKQWLVEKE----LMVSVLGPLSIDPNMLNTQRQQVQILL 2615
Query: 1241 RESIDGKLPSTDQQESCS----STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
+E K P +Q + S PG E+P + + V + W S + S
Sbjct: 2616 QEFATRK-PQYEQLTAAGQGILSRPG-EDPSLRGIVKEQLAAVTQK-----WDSLTGQLS 2668
Query: 1297 AL-----QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Q Q ++ L+ + + +L+ K+SS+ + T QL E K
Sbjct: 2669 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL-ETAQKMKQ 2727
Query: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
EI+ K A+ E L ++ L+ E R+L+ L + + K E V +L
Sbjct: 2728 EIQQEKKQIKVAQALCEDLSALVKEEYLKA---ELSRQLEGILKSFKDVEQKAENHVQHL 2784
Query: 1412 SG---------QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462
Q+S A + E + I A LE K+H + K L +
Sbjct: 2785 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-S 2843
Query: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN-----KSLQEELSLARGTIERLT 1517
M +K GE K Q K AAL + +K N K ++E + + ++E+
Sbjct: 2844 HMYEKTIAEGENLLLKTQGSEK--AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2901
Query: 1518 KSLADVESQV----SAQNK-----------EKDTVLGRLALLQEERDKLITEMDRSLLEN 1562
K VE+ QN E + + +L LQ+E D+ ++ LL N
Sbjct: 2902 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE--LLNN 2959
Query: 1563 --QSLSSSCESLKLALEGLTEDKEKLVKEI----ESLKSSKIA------ESTEWQEKHKE 1610
SL S CE K E +T++ + L++++ E L S K + E+QE KE
Sbjct: 2960 TANSLLSVCEIDK---EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3016
Query: 1611 LQKEYEIL---LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
+++ + L ++++ ++A +++ Q+K S +A K + + + A
Sbjct: 3017 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK--------SLQALKHQVDLAKRLA 3068
Query: 1668 EQEMEEMKEKMRKFAKSKQQKILELE---EENDRLRAEVHPAGDTAKECMETLLSSNASM 1724
+ + E + +K +L++E +E+ L +V D +ET L
Sbjct: 3069 QDLVVEASD-----SKGTSDVLLQVETIAQEHSTLSQQV----DEKCSFLETKLQGIGHF 3119
Query: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
+ + + ++ + S M+ +E +Q K I+ + K L A+ + N+T
Sbjct: 3120 QNTIREMFSQFAEFDDELDS-MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTC 3178
Query: 1785 ----VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
TEE + + G + ++LS C++ + A++ V +E + L+
Sbjct: 3179 KMMLATEETSPDLVGIKRDLEALSKQ----CNKLLDRAQAREEQVEGTIKRLEEFYSKLK 3234
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
+ L ++ EE + ++T+ + N + ++ K+ E++ LQ + +N L Q
Sbjct: 3235 EFSILLQKAEEHEESQGPVGMETETINQQLN--MFKVFQKE-EIEPLQGKQQDVNWLGQG 3291
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
+ + ++ T + E + DD+ R LN + + +A + + +++
Sbjct: 3292 LIQSAAKSTST-QGLEHDLDDVNARWKT----LNKKVAQRAAQLQEALLHCGRFQDALES 3346
Query: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
L + + EE LV + +E K+ AQ + K LQ LL +++
Sbjct: 3347 LLSWMVDTEE----LVANQKPPSAEF------KVVKAQIQ-----EQKLLQRLLDDRKST 3391
Query: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
V+ ++++ EKI+ ++ ++ S L+ E L E R + +L
Sbjct: 3392 VEVIKRE----GEKIATTAEPADKVKILKQLSL--LDSRWEALLNKAETRNR---QLEGI 3442
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEE-----KHL 2135
V+ E L + L ++ N E + +Q + +E + + ++ KHL
Sbjct: 3443 SVVAQQFH-ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3501
Query: 2136 KEKKNMQEKLDAL--RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
+ ++ + L L R +K ++ + QV + ++ E L + F +
Sbjct: 3502 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3561
Query: 2194 MSSLQDDRDRVIDEAKKWERK--FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
L + + V D+ K + ++ + ++ E+R+ +++ + K + Q ++ EL
Sbjct: 3562 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLEL- 3620
Query: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA--- 2308
+ + D+ + ++ + K L + + L Q + HS+ EL
Sbjct: 3621 --LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3678
Query: 2309 -KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-SKFSYEQLETDLQAS 2366
K+E EL S + Q+ + + + L+ + +A + + ++ S LE +
Sbjct: 3679 DKVEVELLSYETQVLK-GEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRA 3737
Query: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
RE ++ E N + + + ++ K E I AI LR Q + + E E E+ ++
Sbjct: 3738 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAI--LRSQQFDQAADAELSWITETEKKLM 3795
Query: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS------------MSSLQNDRD 2474
+ + D+T+ ++ KT E ++ K +D VKS S++ D
Sbjct: 3796 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLD 3855
Query: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534
+++ +Y + I E+ ++ A + N+ E L + + S ++L A +
Sbjct: 3856 KVLKNYDTI----CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPAL 3911
Query: 2535 QY------REDLNQV----------ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
+Y +E+ Q+ I + QLLE+ + ++ KY +
Sbjct: 3912 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY-- 3969
Query: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
+ ED+++ AL E ++ + + + L R V L++ ++ ++K +
Sbjct: 3970 -SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4028
Query: 2639 EE-------VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
E + +L L+ + ++R E+ K+ + K ++DKL + +
Sbjct: 4029 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA--VQDKLDQMV------- 4079
Query: 2692 GIMRNETETAEERVAELARDLVEMEQK-------LLMVTKENKGLTAQIQSFGRSMSSLQ 2744
I N EER A+L D++E+ +K L++ K+ + ++ G S ++
Sbjct: 4080 FIWENIHTLVEEREAKLL-DVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4138
Query: 2745 NSRDHA---NEELDELKRKYDASLKELAQL------KEQGLLNRERDALLSETAFSMNST 2795
++ A EE+D L+ + D + ++L ++ ++ + D L S S+N
Sbjct: 4139 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKA 4197
Query: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
++ + LE+ Q + + L + ++ + ++ S S L+ + + EL++F
Sbjct: 4198 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI-EELKQF 4256
Query: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH 2915
KSE +Q+ E++ L Q + +++TE
Sbjct: 4257 -KSEAYQQQI------------------------------EMERLNHQAELLLKKVTE-- 4283
Query: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975
++ QD +++ + L + ++ QH+L + Q+ A+
Sbjct: 4284 --ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG-----------QFQHALD 4330
Query: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035
+ L+H + L+ E + + ++++ + + Q+ V L
Sbjct: 4331 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL--AHQSTVEAVNKAGNDLI 4388
Query: 3036 DSL--KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVL 3093
+S +E + +++ LN + +LE+ QL +LR+ + +G++ + L
Sbjct: 4389 ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL---DGALRQAKGFHGEIEDLQQWL 4445
Query: 3094 EKQVQELQAGPLNIDVAPGAPQEKNGVHRK--SDPEELREPQQSFSEAQQQL-------- 3143
+ L A + P +E+ VH + + E E +S + QQ+
Sbjct: 4446 TDTERHLLASK-PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSA 4504
Query: 3144 -CNTRQEVNELRKLLE----EERDQRVAAENALSVAEE 3176
N Q++N L++ E + +++ E AL++A E
Sbjct: 4505 ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4542
Score = 204 bits (520), Expect = 9e-52
Identities = 660/3577 (18%), Positives = 1381/3577 (38%), Gaps = 604/3577 (16%)
Query: 37 ESDMEFNNTTQED-----VQERLAYAEQLVVELKDIIRQKDVQLQQKD--------EALQ 83
+S + N T+E+ VQ+ L + +++ V+L D+ + A++
Sbjct: 619 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 678
Query: 84 E-ERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK-HD--KSS 139
E E + KI ++++ A KLT K + +++Q +L T E L H+ +
Sbjct: 679 EFESSLKEAKISEIQMTAPLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 737
Query: 140 TEE-----EMEIEKIKHKLQEKEELISTLQ---AQLTQA--QAEQPAQSSTEMEEFVMMK 189
T E E E E++ + E+ I+ + A+L + Q E+ +S E+ E ++++
Sbjct: 738 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 797
Query: 190 QQLQEK--EEFISTLQAQLSQT-QAEQAAQQVVREKDARFE--------TQVRLHEDELL 238
E + + +Q Q S Q Q +Q ++E A FE T + + +
Sbjct: 798 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 857
Query: 239 QLVTQADVETEMQQKLRVLQRKLEEHEE---------SLVGRAQVV-------------- 275
Q D + + + ++Q +EE EE +L+G+A+ +
Sbjct: 858 QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKT 917
Query: 276 --------DLLQQELTAAEQRNQILSQQLQQM----------EAEHNTLRNTVETEREES 317
D Q E+T + +L+ + EA ++ TV +E+
Sbjct: 918 SIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEA 977
Query: 318 KILLEKMELEVAERKLSFHNLQEEM------HHLLEQFEQAGQAQAELESRYSALEQKHK 371
L ++E + +H M H+L+ + ++
Sbjct: 978 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRI------------------- 1018
Query: 372 AEMEEKTSHILSLQKT-GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
+ S++ S++ E Q L+ + L+D E V S I QLE ++
Sbjct: 1019 -----RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVC 1073
Query: 431 SKEISQFLNRLPL-QQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL 489
+ + L +Q E+ +V N + E+ Q R ++ +
Sbjct: 1074 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 1133
Query: 490 SSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV-- 547
E E+LK E E+L + + N+ E + + S V + ++ V
Sbjct: 1134 RITEQEKLKKELERLKDDLGTI--TNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYS 1191
Query: 548 LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQ--KEMKQMEGEG 605
+ +T+ K K ++++L + A+ + + +L + A AD ++ +KQ E
Sbjct: 1192 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE- 1250
Query: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665
+++ Q F + +E ++K +A ++ +T +E L
Sbjct: 1251 ---------VDEKRQVFHALEDE------LQKAKAISDEMFKTYKERDL----------- 1284
Query: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN---LDEKAKEISNLN 722
D D + + Q+ ++ +++ +LE K+ + Y LD+ +++
Sbjct: 1285 -DFDWHKEKADQLVERWQNVHVQIDNRLRDLE-GIGKSLKYYRDTYHPLDDWIQQVETTQ 1342
Query: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVK-ELSMVTELRAQVKQLEMNLAEAERQRR 781
+ I+E N NS ++ L+S+++ + S + E + +Q +
Sbjct: 1343 RKIQE---NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK------- 1392
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL--------- 832
DYE QT + + ++ + +++ E D++ +++ TL
Sbjct: 1393 -DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1451
Query: 833 --IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
++ L+ + ++ E E E E+ + + V +S+ L E ++
Sbjct: 1452 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1511
Query: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950
T ++ + E Q + +KM +EE+ L ++KTL+E NLL +E K+ Q
Sbjct: 1512 TKKEQLSEALQTIQLFLAKHGDKMT--DEERNELEKQVKTLQESYNLLF-SESLKQLQ-- 1566
Query: 951 EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL-LQRV 1009
+++ S +K ++ Q KE+LQ DLL + + +A +I + L++
Sbjct: 1567 -ESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY 1625
Query: 1010 SRLEEELANLKDESKKEIPLSET---------ERGE--VEEDKENKEYSEKCVTSKCQEI 1058
+EEL KD L+E E GE +EDK E KC+++
Sbjct: 1626 QSKQEELQ--KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1683
Query: 1059 EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN-QIDLLQAEISE 1117
+ +Q+ E + + K+ EK+AA +Q + ++ L +N D +A
Sbjct: 1684 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1743
Query: 1118 NQAIIQKLITSNTDASDGDSVALVKET-----VVISPPCTGSSEHWKPELEEKILALEKE 1172
Q I Q + T +GD + + E ++ G + L ++ ++ +
Sbjct: 1744 KQVIEQ----NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1799
Query: 1173 KEQLQKKLQE---ALTSRKAILKK-----AQEKERHLREELKQQKDDYNRLQEQFDEQSK 1224
E++ + Q A S + +L+K + E++ L++ +K+ K Y + +++ K
Sbjct: 1800 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK 1859
Query: 1225 ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
++ ++L + E S + E+ + L T+ + +
Sbjct: 1860 LTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM-------TKLKRQKSF 1912
Query: 1285 CPDWPSHSEDASALQ-GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343
D SH D + G V + + + KV+ +L ++ L
Sbjct: 1913 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1972
Query: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
+ N G ++ L E + L L++ + + +HL E + K + +
Sbjct: 1973 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS--KHLSE---PIAVDPKNLQR 2027
Query: 1404 KEEDVSYLSGQLSEKEAALTKIQ--TEII---------EQEDLIKALHT---QLEMQAKE 1449
+ E+ L GQ+S ++ A+ K++ E++ + D+ K L + E +K
Sbjct: 2028 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2087
Query: 1450 HDERIKQLQVELCEMKQKPEEIGE--------ESRAKQQIQRKLQAALISRKEALKENKS 1501
+ER ++LQ+ L + + E ES K+Q Q L + + ++ + +N
Sbjct: 2088 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--QDIISKNIM 2145
Query: 1502 LQEELSLARGTIERLTKSL------ADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
L+++++ + +I + + + D + S Q K KD + R + + + + +M
Sbjct: 2146 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKD-LSARFSEASHKHKETLAKM 2204
Query: 1556 DRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
+ + + + E L+ LE T+ + + K++ L ++E+ E K L+
Sbjct: 2205 EELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2264
Query: 1613 KEYEILLQ------------SYENVSNEAERIQHVVEAVRQEK-------------QELY 1647
+ +L + E +N +++ + + + ++++K Q L
Sbjct: 2265 VLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLV 2324
Query: 1648 GKLRS--TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR--LRAEV 1703
L+S E KK Q +++ + E +K + K E+++ N+ +
Sbjct: 2325 KSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL 2384
Query: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
A T + + + S A + E E +K S+ + +S +DL +
Sbjct: 2385 ISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2444
Query: 1764 EGNVSK-QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
+ +++ L +K +++ + Q + + + PT +E+V + N
Sbjct: 2445 KDKIAELNTKLSKLQKAQEESSAMMQWLQKM---NKTATKWQQTPAPTDTEAVKTQVEQN 2501
Query: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF-------------------- 1862
K F + E+ + ++ +LK+++ L EE E
Sbjct: 2502 ----KSFEA--ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL 2555
Query: 1863 ----SQTLENEKNTLLSQISTKDGELKMLQEEVTKM-----------NLLN---QQIQEE 1904
Q LE N L+Q T + +LK E M N+LN QQ+Q
Sbjct: 2556 TIDRQQKLEESSNN-LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2614
Query: 1905 LSRVTKLKETAEE-------------EKDDLEERLMNQLA-------ELNGSIGNYCQDV 1944
L K E+ E L + QLA L G + + C +
Sbjct: 2615 LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWI 2674
Query: 1945 TDAQIKNELLESEMKNLKKCVSELEEE------------------------KQQLVKEKT 1980
A +K+ +S +++L +S+L+ + KQ++ +EK
Sbjct: 2675 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2734
Query: 1981 KVE----------SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
+++ + +++EYL+ Q E K +++ ++ + V+ LQ C
Sbjct: 2735 QIKVAQALCEDLSALVKEEYLKAELSRQLE----GILKSFKDVEQKAENHVQHLQSACAS 2790
Query: 2031 YQEKISALERTVKA-LEFVQTESQKDLEITK--ENLAQAVEHRKKAQAELASFKVLLDDT 2087
+ + R +A L+ + E K I+ + L ++ K L + + + T
Sbjct: 2791 -SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT 2849
Query: 2088 QSEAARVL-----ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
+E +L ++ L+ +L + K + + KQ E E +L+++ EK LK K+ ++
Sbjct: 2850 IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE-RENKLKESLEKALKYKEQVE 2908
Query: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKE-----VQQLQENLDSTVTQLAAFTKSMSSL 2197
+ + + +LE EI+ L+ + E ++ LQ+ +D + + +SL
Sbjct: 2909 TLWPWIDKCQNNLE----EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL 2964
Query: 2198 ----QDDRDRVIDEAKKWERK---FSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIH 2246
+ D++ V DE K +K ++ + SK E + ++ V K+ RQ+
Sbjct: 2965 LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 3024
Query: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQK----------------------------- 2277
E+L I+ S Q + +K T +Q QQK
Sbjct: 3025 KEQLDIHDSL---GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGT 3081
Query: 2278 -----VCDTLQGENKELLSQLEETRHLYHSS-------QNELAKLESELKSLKDQLTDLS 2325
+T+ E+ L Q++E + QN + ++ S+ D+L ++
Sbjct: 3082 SDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMA 3141
Query: 2326 ---NSLEKCKEQKGNLEGIIRQQE---ADIQNSKFSYEQLETDLQASRELT--SRLHEEI 2377
E ++QK ++ +++ E A N+ + + + + S +L R E +
Sbjct: 3142 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEAL 3201
Query: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV-- 2435
+ + K++ +EE ++ I L + + K +KE LL + EE EE++ V
Sbjct: 3202 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSK-LKEFSILLQKAEE-----HEESQGPVGM 3255
Query: 2436 --DKTNQLMETLKTIKKENI---QQKAQ---------LDSFVKSMSS--LQNDRDRIVGD 2479
+ NQ + K +KE I Q K Q + S KS S+ L++D D +
Sbjct: 3256 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNAR 3315
Query: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
++ L ++ + ++ +QEA + ++ + L S M D A +++
Sbjct: 3316 WKTLNKK----VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3371
Query: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR--RSFNALQEEK 2597
Q+ Q+++LL+ L K + EK+ + E + ++ + + L
Sbjct: 3372 KAQI------QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRW 3425
Query: 2598 QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
+ L + E+ + ++ V A Q TL + L E+ + + + + K
Sbjct: 3426 EALLNKAETRNRQLEGIS--VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK---- 3479
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
LEE++ Q +A +ED + KHLH I ++ + ++ + ++ Q
Sbjct: 3480 LEEQI--AQHKA------LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ 3531
Query: 2718 KLLMVTKENKGLTAQI--------QSFGRSMSSLQNSRDHANEELDELK-RKYDA----- 2763
+ +E +++ + FG L N + +++L +L + Y
Sbjct: 3532 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWK 3591
Query: 2764 SLKELAQLKEQGLLNRER--DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS 2821
EL L+E LL ++ ALL+ +T + L +KL + + ++ + + LS
Sbjct: 3592 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL-EAIKARYKDITKLS 3650
Query: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
+ + + Q ++ + S E +++E S E + + S + + LKK
Sbjct: 3651 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3710
Query: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
K K L +++ + EL P +A +E +K A + L +
Sbjct: 3711 E-----------AKNNKALLDSLNEVSSALLELVPWRA--REGLEKMVAEDNERYRLVSD 3757
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001
++ + E + +S + + L I++ +++L L ++ E +S+Q
Sbjct: 3758 TITQKVEEIDAAILRSQ---QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ---- 3810
Query: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL--------RIQQLNS 3053
+Q Q+ + E D +LV + T ++ K+ +K+L I Q+NS
Sbjct: 3811 -LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3869
Query: 3054 NFSQLLEEKNTLSIQLCDT------------------------SQSLRENQQHYGDLLNH 3089
LE +L Q +T ++LR+ Q+ + L
Sbjct: 3870 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3929
Query: 3090 CAVLEKQVQEL-QAGPLNIDVAPGAPQEKNGVHRKSD------PEELREPQQSFSEAQQQ 3142
A + + ++ + GP ++++PG + +D E++++ + EA Q
Sbjct: 3930 IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ 3989
Query: 3143 LCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
+++++ + L E +R+ ++S E+I+
Sbjct: 3990 STQFHDKIDQILESL-ERIVERLRQPPSISAEVEKIK 4025
Score = 176 bits (446), Expect = 3e-43
Identities = 620/3279 (18%), Positives = 1259/3279 (38%), Gaps = 588/3279 (17%)
Query: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER-KAADNKIKKLKLHAKAKLT 105
Q+D+Q ++V ++ +++ +L Q+D+AL E++ A K ++L L A+
Sbjct: 1633 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1692
Query: 106 SLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK-----SSTEEEMEIEKIKHK-------- 152
L+K + + + Q EE +K + S+ +++ E KHK
Sbjct: 1693 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGT 1752
Query: 153 ----------LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ-EKEEFIST 201
+ E++E+ L + + Q T E Q+++ + E+ IS
Sbjct: 1753 HFQEGDGKSAIGEEDEVNGNL------LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1806
Query: 202 LQAQLSQTQAEQAAQQVVREKDARF---ETQVRLHED--ELLQLVTQADVETEMQQKL-R 255
QA + TQ+ Q V+ EK ++ E + +L ++ EL A E+E + KL
Sbjct: 1807 HQAVIIATQSAQ----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 1862
Query: 256 VLQRKLEEHEESLVGRAQVVDLLQQEL----TAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
LQ +LE+ + + +QEL A+ N ++++ +Q + + + +
Sbjct: 1863 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1922
Query: 312 ------------------TEREESKILLEKMELEVAERKLS-----FHNLQEE------- 341
++R+ K+ EV +RKL F +L +
Sbjct: 1923 LRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-QRKLDHATDRFRSLYSKCNVLGNN 1981
Query: 342 MHHLLEQFEQAGQAQAELESRYSALE---QKHKAE------------MEEKTS---HILS 383
+ L+++++ A L + A E KH +E +EE + I S
Sbjct: 1982 LKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISS 2041
Query: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL 443
Q ++L+ + L D LL KN+ IQ+ D + + +++S+ +N
Sbjct: 2042 QQVAVEKLKKTAEVLLDARGSLLPAKND--------IQKTLDDIVGRYEDLSKSVNERNE 2093
Query: 444 QQHETASQT-SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
+ T +++ S D +E + N+ S K E+G + L+S L+++ ++N
Sbjct: 2094 KLQITLTRSLSVQDGLDEMLDWMG--NVESSLK-------EQGQVPLNSTALQDIISKNI 2144
Query: 503 KLSSQITLLEAQ-NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
L I ++ N E ++ E + D + S A+ + S KHKE
Sbjct: 2145 MLEQDIAGRQSSINAMNEKVKKFMETT--DPSTASSLQAKMKDLSARFSEASHKHKETLA 2202
Query: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
+ E+K E L +LQ + + + +++ G ++ +++++ +
Sbjct: 2203 KMEELKTKVELFENLSEKLQTFLETKT-------QALTEVDVPGKDVTELSQYMQESTSE 2255
Query: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
F L ++ KE +S H + + + L K K+ D + C
Sbjct: 2256 FLEHKKHLEVLHSLLKEISS--HGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2313
Query: 682 HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA 741
Q++L+ Q+L L + + + + + +L + +E+ KK + S
Sbjct: 2314 -QEQLDAF--QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPE 2370
Query: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHS 800
+ + + +S +S VT + ++ A + + E A+ L + +
Sbjct: 2371 IQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2430
Query: 801 LSIEAKSKDV------KIEVLQNELDDVQLQFSEQSTLIRSLQSQL-------------- 840
I +D+ KI L +L +Q E S +++ LQ
Sbjct: 2431 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2490
Query: 841 ---------QNK--ESEVLEGAERVRHISSKVEEL-------------SQALSQKELEIT 876
QNK E+E+ + +V+ + K+ EL Q L++ + +
Sbjct: 2491 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQ 2550
Query: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV---------E 927
+++QL +++ QQ +EE +T+ + L E++ + V
Sbjct: 2551 ELNQLTIDR-------QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2603
Query: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ---HEFDLL 984
+ T ++Q+ +L + +K Q E+ G+ E I KE+L ++D L
Sbjct: 2604 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2663
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS----------ETER 1034
+ R + A++ + + L ++L++L ++ + +S ET +
Sbjct: 2664 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2723
Query: 1035 GEVEEDKENKEYSEKCVTSKCQEI-----EIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
+E ++ K+ K + C+++ E YLK +S + + KD+E+K AE
Sbjct: 2724 KMKQEIQQEKKQI-KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQK--AENH 2780
Query: 1090 FQALVK------QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Q L Q Q +D +D + E +++ I KL + L+K+
Sbjct: 2781 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES---------LIKD 2831
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEK----EKEQLQKKLQEALTSRKAILKKAQEKER 1199
S T S ++ + E L K EK LQ +L T+ K+ +E+E
Sbjct: 2832 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2891
Query: 1200 HLREEL------KQQKDDY--------NRLQE-QFDEQSKENENIGDQLRQLQ------- 1237
L+E L K+Q + N L+E +F E EN +L+ LQ
Sbjct: 2892 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2951
Query: 1238 --IQVRESIDGKLPST---DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPS-- 1290
+++ + L S D++ L + + TEQ H++ N+ +
Sbjct: 2952 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3011
Query: 1291 -------------------HSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV------ 1325
H S + ++ Q K ++A K +++L
Sbjct: 3012 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3071
Query: 1326 ------SSTTSELTKKSEEVFQ----LQEQINK---------QGL--------------- 1351
S TS++ + E + Q L +Q+++ QG+
Sbjct: 3072 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3131
Query: 1352 ----EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
E++S+ V +AE +LQ++ E+ + + LE L ++ K++ EE
Sbjct: 3132 EFDDELDSMAPVGRDAE----TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3187
Query: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE---RIKQLQVELCEM 1464
L G + EA L+K +++ D +A Q+E K +E ++K+ + L +
Sbjct: 3188 SPDLVGIKRDLEA-LSKQCNKLL---DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3243
Query: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS-LARGTIERLTKS---- 1519
++ E G + I ++L + +KE ++ + Q++++ L +G I+ KS
Sbjct: 3244 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3303
Query: 1520 -----LADVESQVSAQNKEKDTVLGRLALLQE--------------------ERDKLITE 1554
L DV ++ NK+ V R A LQE + ++L+
Sbjct: 3304 GLEHDLDDVNARWKTLNKK---VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3360
Query: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
E + + + + KL L+ L +D++ V+ I+ + KIA + E +K K L K+
Sbjct: 3361 QKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKR-EGEKIATTAEPADKVKIL-KQ 3417
Query: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR-------------------STEA 1655
+L +E + N+AE +E + Q+ + L T+A
Sbjct: 3418 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3477
Query: 1656 NKKETEKQLQEAEQE--MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC 1713
+K E + +A ++ + K + + + K+L E+ D +++++ + E
Sbjct: 3478 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3537
Query: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQAN 1772
E S + +++ L K+ E + L D LS+ VQD + EG +Q+
Sbjct: 3538 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGLWKQQSE 3595
Query: 1773 LEATE-----KHDNQTNVTEEGTQSIPGETEEQ--------DSLSMSTRPTCSESVPSAK 1819
L + + N G + + T ++ +++ + S AK
Sbjct: 3596 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655
Query: 1820 SANPAVS---KDFSSHDEINNYLQQID-----------------QLKERIAGLEEEKQKN 1859
+ A+ + S+H+E+ +L +++ Q + R L++E + N
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3715
Query: 1860 KEFSQTLENEKNTLLSQIS--TKDGELKMLQEEVTKMNLLNQQIQEELSRVTK--LKETA 1915
K +L + LL + ++G KM+ E+ + L++ I +++ + L+
Sbjct: 3716 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3775
Query: 1916 EEEKDDLEERLMNQLAELNGSIGNYC--QDVTDAQIK-NELLESEMKNLKKCVSELEEEK 1972
++ D E + + + S+G+ QD T AQ++ + E+ K + +L +
Sbjct: 3776 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3835
Query: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ 2032
+++ ++ E + K+ L+K+ K + + + QL+ R Q
Sbjct: 3836 HKIMTACSEEEKQSMKKKLDKV------------LKNYDTICQINSERYLQLE----RAQ 3879
Query: 2033 EKISALERTVKALEFVQTESQKDLE------ITKENLAQAVEHRKKAQAELASFKVLLDD 2086
++ T + L TE+Q + + E L Q E ++ + +A K +D
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3939
Query: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLD 2146
++L + +Q + + Q ED+++R +E + + +K+D
Sbjct: 3940 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEA-ISQSTQFHDKID 3998
Query: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206
+ + E + + + +K +Q+ EN + +V
Sbjct: 3999 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSV---------------------- 4036
Query: 2207 EAKKWERKFSDAIQSKEEEIRL-----KEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
+ +K + + Q EE I K+ + ++D+L QM E NI L ++
Sbjct: 4037 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE----NIHTLVEER 4092
Query: 2262 QIWESKAQTEVQLQQKV-CDTLQ-----GENKELLSQLEETR---HLYHSSQNELAKLES 2312
E+K ++L +K CD + + ++ + LE+ + Q +
Sbjct: 4093 ---EAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4149
Query: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS---------KFSYEQLETDL 2363
E+ L+++L + N + G + I ++ D NS K ++LE +
Sbjct: 4150 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4209
Query: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE 2423
QA+ + L + + ++G + A I + ++I+EL+ S+ ++
Sbjct: 4210 QAAVQYQDGLQAVFDWVD------IAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQ 4263
Query: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
I +E N +A +L+ LK + +E+ + Q D ++ + +RI+ +L
Sbjct: 4264 QIEMERLNHQA-----ELL--LKKVTEESDKHTVQ-DPLMELKLIWDSLEERIINRQHKL 4315
Query: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
E L++ Q A E GL S + + ++ EL ++ N V
Sbjct: 4316 EGALLAL-----GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 2544 ITIKDSQQ------KQLLEVQL-QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
+ + + + L+E ++ L+NK L ++ + E E ++ + +
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4430
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTL-GLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
+ EIE L+ ++ R + A + G L QL V E A + + +
Sbjct: 4431 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4490
Query: 2656 AELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD---- 2711
+ ++ L K A + + + LK++ + + NE +T E LA +
Sbjct: 4491 QKGQQMLARCPKSAETNIDQDINNLKEKWESVE----TKLNERKTKLEEALNLAMEFHNS 4546
Query: 2712 -------LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
L + EQ L + ++ + L + H E++ EL K
Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH-REQIIELD-KTGTH 4604
Query: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
LK +Q ++ L+ ++ L+S S EK+ Q+L+ + L
Sbjct: 4605 LKYFSQKQDVVLI---KNLLISVQ------------SRWEKVVQRLVER-------GRSL 4642
Query: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
+D+ + + F +A + L W LE+ KS + + A P ++ K+
Sbjct: 4643 DDARKRAKQFHEAWSKLME-----W--LEESEKSLDSELEIANDPDKIKTQLAQHKEFQK 4695
Query: 2885 SL---------QNDRDRLLKELKNLQQQYLQINQEITEL 2914
SL N R LKE +L L+++ ++EL
Sbjct: 4696 SLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4734
Score = 156 bits (395), Expect = 3e-37
Identities = 482/2513 (19%), Positives = 1005/2513 (39%), Gaps = 376/2513 (14%)
Query: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA---QLTQAQAEQ--PA 176
L + S +S H + ++ +K+K ++Q++++ I QA L+ E+ A
Sbjct: 2698 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA 2757
Query: 177 QSSTEMEEFVMMKQQLQEK-EEFISTLQ-AQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
+ S ++E + + +++K E + LQ A S Q +Q ++ D + E Q + H
Sbjct: 2758 ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP 2817
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
+ KL VL+ +++H++ + E T AE N +L
Sbjct: 2818 ---------------ISAKLDVLESLIKDHKD--FSKTLTAQSHMYEKTIAEGENLLLKT 2860
Query: 295 QLQQ---MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQ 351
Q + ++ + NT++ +T ++ K K++ E E+ L + E + +++ +
Sbjct: 2861 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLK-ESLEKALKYKEQVETLWPWIDKCQN 2919
Query: 352 AGQA------QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405
+ AE E+ + L+ K EM++ + L T L S C+ K+ +
Sbjct: 2920 NLEEIKFCLDPAEGENSIAKLKSLQK-EMDQHFGMVELLNNTANSLLSVCEIDKE----V 2974
Query: 406 LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465
+ D+N+ +Q + + +QL K + + + Q V
Sbjct: 2975 VTDENKSLIQK---VDMVTEQLHSKKFCLENMTQKF------------------KEFQEV 3013
Query: 466 TEENIASLQ--KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
++E+ LQ K +++ + G+ S+ L L+ + + L +A + +
Sbjct: 3014 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-------QALKHQVDLAKR 3066
Query: 524 VSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581
+++ +V+ ++ + +S DVL T +Q+H LS ++ E+ +FL+ +LQ
Sbjct: 3067 LAQDLVVEASDSKGTS------DVLLQVETIAQEHSTLS------QQVDEKCSFLETKLQ 3114
Query: 582 G-KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE-- 638
G + E+ Q E + +AP+ G+D + ++ ++ A K+
Sbjct: 3115 GIGHFQNTIREMFSQFAEFDDELDSMAPV---------GRDAETLQKQKETIKAFLKKLE 3165
Query: 639 --QASTEHQSRTSEE-ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
AS ++ ++T + ++ + +L K+D L A+ QC++ L+R +++ +
Sbjct: 3166 ALMASNDNANKTCKMMLATEETSPDLVGIKRD----LEALSK--QCNK-LLDRAQAREEQ 3218
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755
+E + +E Y K KE S L Q EE +++ +E +Q L+ K
Sbjct: 3219 VEGTIKRLEEFYSK-----LKEFSILLQKAEEHEES----QGPVGMETETINQQLNMFKV 3269
Query: 756 LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815
Q KQ ++N Q + +++ L + ++ K+ + K+
Sbjct: 3270 FQKEEIEPLQGKQQDVNWLG---QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3326
Query: 816 QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG---AERVRHISSKVEELSQALSQKE 872
+L + L + SL S + + E V + + + ++++E Q L Q+
Sbjct: 3327 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE--QKLLQRL 3384
Query: 873 LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932
L+ K ++ KR+ E + T E D+ + +++ L+ +L + +T
Sbjct: 3385 LDDRKSTVEVI--KREGEKIATTAEPADK------VKILKQLSLLDSRWEALLNKAETRN 3436
Query: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG-QISKEELQHEFDLLKKENEQR 991
QL +S + E +E NE + +++ P G Q SK E E +
Sbjct: 3437 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE----------EQIAQ 3486
Query: 992 KRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV---EEDKENKEYSE 1048
+ L+ +IN + L + + + L L K++ S+ + +V E +++ SE
Sbjct: 3487 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3546
Query: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA----EEQFQALVKQMNQTLQDK 1104
+ C + E EVEL + ++ +KL+ + + L KQ ++ +
Sbjct: 3547 LLQQALCNA------KIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL---R 3597
Query: 1105 TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP----CTGSSEHWKP 1160
Q D+L + + +QA++ L + GD V ++++ + T S
Sbjct: 3598 VLQEDILLRKQNVDQALLNGL--ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655
Query: 1161 ELEEKILA---LEKEKEQL----QKKLQEALTSRKAILKKAQEKERHLR-EELKQQKDDY 1212
LE+ + L E+L K E L+ +LK + + +R +ELK++ +
Sbjct: 3656 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3715
Query: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE----SCSSTPGLEEPLF 1268
L + +E S L + + RE ++ K+ + D + S + T +EE
Sbjct: 3716 KALLDSLNEVSSA------LLELVPWRAREGLE-KMVAEDNERYRLVSDTITQKVEEIDA 3768
Query: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ--IKAQLKEIEAEKVELELKVS 1326
++ L W + +E G + Q AQL+ + +E+ L+
Sbjct: 3769 AILRSQQFDQAADAEL--SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI-LRHK 3825
Query: 1327 STTSELTKKSEEVFQLQEQINKQGLEIES---LKTVSHEAEVHAESLQQKLESSQLQIAG 1383
+L K ++ + KQ ++ + LK ++++E Q + L
Sbjct: 3826 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQF 3885
Query: 1384 LEHLRELQPKLDELQKLISK-------------KEEDVSYLSGQLSEKEAALTK------ 1424
E EL P L E Q +IS+ ++E+ L ++E + + K
Sbjct: 3886 WETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3945
Query: 1425 ------------IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ---LQVELCEMKQKPE 1469
IQ + + + L + ++ +A DE I Q ++ ++ + E
Sbjct: 3946 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4005
Query: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
I E R I +++ KE + ENK++ ++ + E L + ++ ++
Sbjct: 4006 RIVERLRQPPSISAEVEKI----KEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4061
Query: 1530 QNKEKDTV-----LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
+K+ L ++ + E L+ E + LL+ L+ ++L +D +
Sbjct: 4062 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4121
Query: 1585 KLVKEIES--LKSSKIAESTEWQEKHKE----LQKEYEILLQ-SYENVSNEAERIQHVVE 1637
++++E + S + + E E +E LQ+E +I++ E ++ E + +V+
Sbjct: 4122 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4181
Query: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
E + L K+ +L+EA Q + ++ + Q + + +
Sbjct: 4182 KSIDELNSAWDSLNKAW---KDRIDKLEEAMQAAVQYQDGL--------QAVFDWVDIAG 4230
Query: 1698 RLRAEVHPAG---DTAKECMETL--LSSNASMKE-ELERVKMEYETLSKKFQS------- 1744
A + P G +T K+ +E L S A ++ E+ER+ + E L KK
Sbjct: 4231 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4290
Query: 1745 ---LMSEK---DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPG 1795
LM K DSL E + + +H++EG + + EG Q G
Sbjct: 4291 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4350
Query: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSK------DFSSHDEINNYLQQIDQLKERI 1849
+ + ++ V + +S AV+K + S+ +E +N +++ L +R
Sbjct: 4351 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4410
Query: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK----------MNLLNQ 1899
+ E+ ++ K+ + + L Q GE++ LQ+ +T + L +
Sbjct: 4411 QNVLEKTEQRKQ-------QLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4463
Query: 1900 QIQEELS---RVTKLKETAEEEKDDLEERLMNQLAELNGSIG-NYCQDVTDAQIKNELLE 1955
+E+L+ V E EE L ++ LA S N QD+ + + K E +E
Sbjct: 4464 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4523
Query: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+++ K ++LEE ++ ++ +++ + A++ S + + +
Sbjct: 4524 TKLNERK---TKLEEALNLAMEFHNSLQ-----DFINWLTQAEQTLNVASRPSLILDTVL 4575
Query: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR-KKAQ 2074
+ E K + ++E+I L++T L++ SQK + +NL +V+ R +K
Sbjct: 4576 FQIDEHKVFANEVNSHREQIIELDKTGTHLKYF---SQKQDVVLIKNLLISVQSRWEKVV 4632
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
L LDD + A + KL + L+ +++S+ S+++ ++ + + + A+ K
Sbjct: 4633 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4692
Query: 2135 LKEKKNMQEKL-DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
++ + + D R L+E L K D + +L++ D+ +
Sbjct: 4693 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSV----- 4746
Query: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEE-----EIRLKE---------------DNC 2233
+R ++EA + +F+DA+Q+ + E +L E DN
Sbjct: 4747 ------ERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4800
Query: 2234 SVLKDQLRQMSIHMEELKINISRL---EHDKQIWESKAQTEVQLQ-QKVCD---TLQGEN 2286
+ +L + + ++ LK + L D W E+ + + VC + Q
Sbjct: 4801 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4860
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
+ L Q EE + H+ LA+ E L+ L D ++L +Q + ++
Sbjct: 4861 EAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKR 4919
Query: 2347 ADIQNS--------KFSYEQLETDLQASRELTSRLHEEI----NMKEQKIISLLSG---K 2391
A++ + + T ++ + EE+ +Q++ S L+G K
Sbjct: 4920 AELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4979
Query: 2392 EEAIQVAIAELR------QQHDKEI--KELENLLSQEEEENIVLEEENKKAVD 2436
+E ++ +A L+ DKE+ +E+E + + E +EE +K D
Sbjct: 4980 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD 5032
Score = 129 bits (324), Expect = 5e-29
Identities = 476/2605 (18%), Positives = 1047/2605 (40%), Gaps = 386/2605 (14%)
Query: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQE------RLAYAEQLVVELKDIIRQK--D 72
D D + + L H ++ + T Q+ QE ++ A+ L +L +++++
Sbjct: 2697 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2756
Query: 73 VQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132
+L ++ E + + K + K + H ++ S +++ ++M L T+ EEQ
Sbjct: 2757 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF-QQMSRDFQAWLDTK--KEEQN 2813
Query: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192
H S+ +++ ++ +++ ++ TL AQ M ++ +
Sbjct: 2814 KSHPISA-----KLDVLESLIKDHKDFSKTLTAQSH------------------MYEKTI 2850
Query: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252
E E + L+ Q S+ A Q ++ F QV+ E++L + + +A + ++
Sbjct: 2851 AEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA---LKYKE 2905
Query: 253 KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN--QILSQQLQQMEAEHNTLRNTV 310
++ L +++ + +L +D + E + A+ ++ + + Q +E +NT + +
Sbjct: 2906 QVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2965
Query: 311 -------ETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG-QAQAELESR 362
E +E+K L++K+++ V E+ S E M ++F++ +++ +L+
Sbjct: 2966 SVCEIDKEVVTDENKSLIQKVDM-VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 3024
Query: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS------ 416
L+ + ++ L++ +T Q+ A D +L QD +A S
Sbjct: 3025 KEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV 3084
Query: 417 ---AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE-ENIAS 472
+TI Q L Q+ E FL Q Q + +++++ + E +++A
Sbjct: 3085 LLQVETIAQEHSTLSQQVDEKCSFLETK--LQGIGHFQNTIREMFSQFAEFDDELDSMAP 3142
Query: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE----ADREVSEIS 528
+ + L+ +K + +LE L A N+ + ++ A T R++ +S
Sbjct: 3143 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3202
Query: 529 -----IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
++D A R E + + + E F K KE S+LL + +E +E + ++ +
Sbjct: 3203 KQCNKLLDRAQAREEQVEGTIKRLEE--FYSKLKEFSILLQKAEEHEESQGPVGMETETI 3260
Query: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
+ +V ++E++ ++G+ + + GQ + +S +E +
Sbjct: 3261 NQQLNMFKVFQKEEIEPLQGK-------QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVN 3313
Query: 644 HQSRTSEE------ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD------ELERLKS 691
+ +T + L +A + + + LS + D + + E + +K+
Sbjct: 3314 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA 3373
Query: 692 QILELEL------NFHKAQEIYEKNLDEKA------------KEISNLNQLIEEFKKNAD 733
QI E +L + E+ ++ ++ A K++S L+ E A+
Sbjct: 3374 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3433
Query: 734 NNSSAFTALSEERDQLLSQVKELS-MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
+ +S Q ++ L+ +T + ++ E +A + + + D+
Sbjct: 3434 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3493
Query: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
++ H + + +K+ + + D VQ + +Q + ++ SE+L+ A
Sbjct: 3494 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR-SELLQQAL 3552
Query: 853 RVRHISSKVE-ELSQALSQKELEITKMD------QLLLEKKRDVETLQQTIEEKDQQVTE 905
I + E EL L++ +++K+ + L +++ ++ LQ+ I + Q V +
Sbjct: 3553 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3612
Query: 906 ISFSMTEKMVQLN-EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
+ E + Q +E + +++ +K + +++ + +E+ +++ L ++
Sbjct: 3613 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3672
Query: 965 EMSP-AGQISKEELQHEFDLLKKEN----EQRKRKLQAALINRKELLQRVSRLEEELANL 1019
E+ ++ E L +E +LK E + R ++L+ N K LL ++ + L L
Sbjct: 3673 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3732
Query: 1020 KDESKKEIPLSETERGE--VEEDKENKEYSEKCVTSKCQEIEIYL---KQTISEKEVELQ 1074
+P E E V ED E +T K +EI+ + +Q + EL
Sbjct: 3733 -------VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS 3785
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQ-DKTNQIDLLQAEISENQAIIQKLITSN---- 1129
I + E+KL + + Q + LQ KT +++L+ ++ II L+ S
Sbjct: 3786 WIT-ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR-----HKDIIDDLVKSGHKIM 3839
Query: 1130 TDASDGDSVALVKETVVI----SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
T S+ + ++ K+ + C +SE + E+ +L + + ++L LT
Sbjct: 3840 TACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL--ERAQSLVNQFWETYEELWPWLT 3897
Query: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI---GDQLRQLQIQVRE 1242
++I+ + E L+QQ++++ +L+E E + + G QL +L
Sbjct: 3898 ETQSIISQLPAPALEY-ETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3956
Query: 1243 SIDGKLPSTD------QQESCSSTPGLEEPLFKATEQHHT-QPVLESNLCPDWPSHSEDA 1295
SI K + D +++ L+E + ++T+ H +LES
Sbjct: 3957 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES------------- 4003
Query: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ---EQINKQGLE 1352
+ +I +L++ + E+E K+ SE S ++ +LQ E + ++G E
Sbjct: 4004 --------LERIVERLRQPPSISAEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4054
Query: 1353 IESLKTVSHEAEVHAESLQQKLESS-----------QLQIAGLEHLRELQPKL--DELQK 1399
+ + ++ + ++ A+++Q KL+ + + A L + EL K D +
Sbjct: 4055 MIA-RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4113
Query: 1400 LISKKE--------EDVSYLSGQLSEKEAALTKIQTEII---EQEDLIKALHTQLEMQAK 1448
+++ K+ ED + +++ A I+ EI E+ D++ L ++L
Sbjct: 4114 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG 4173
Query: 1449 EHDERIKQLQVELCEM---------KQKPEEIGEESRAKQQIQRKLQAA----------- 1488
E D+ I + ++ K + +++ E +A Q Q LQA
Sbjct: 4174 EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4233
Query: 1489 ---------LISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV-- 1537
L + K+ ++E K + E + +ERL A++ + + +K TV
Sbjct: 4234 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEESDKHTVQD 4292
Query: 1538 -LGRLALLQEERDKLIT----EMDRSLLENQSLSSSCESLKLAL---EGLTEDKEKL--- 1586
L L L+ + ++ I +++ +LL + + L L EGL +++ +
Sbjct: 4293 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4352
Query: 1587 --VKEIESLK---------------------SSKIAESTEWQEKHKELQKEYEILLQSYE 1623
EIE K + + ES+ +E LQ + E+L Q ++
Sbjct: 4353 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA-SNLQNKLEVLNQRWQ 4411
Query: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
NV + E+ + ++ ++ + +G++ + +TE+ L A + + + E ++
Sbjct: 4412 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL-ASKPLGGLPETAKEQLN 4470
Query: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
+ E + + ++ + C + S+ ++ +++ +K ++E++ K
Sbjct: 4471 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPK---SAETNIDQDINNLKEKWESVETK-- 4525
Query: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQAN-LEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
++E+ + EE +L + ++ N L E+ N + ++ + +E
Sbjct: 4526 --LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4583
Query: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI-----------NNYLQQIDQLKERIAG 1851
+ + + K+ K FS ++ + + + + +L ER
Sbjct: 4584 FANEVNSHREQIIELDKTGTHL--KYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4641
Query: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ--EEVTKMNLLNQQIQEELSRVT 1909
L++ +++ K+F + L + D EL++ +++ +++ Q+ L
Sbjct: 4642 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4701
Query: 1910 KLKETAEEEKDDLEE---------RLMNQLAELNGSIGNYCQDVTDAQIKNE---LLESE 1957
+ +T L+E +L + L+EL C + Q K E L +
Sbjct: 4702 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4761
Query: 1958 MKN-LKKCVSELEEEKQQLVKEK-TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+ L+ + L + QL +++ + ++ ++ + QKE G ++ + + LK
Sbjct: 4762 FTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS---VQALK 4818
Query: 2016 EKQQEVKQLQKDCIRY----QEKISALERTVKALEF-VQTESQKDLEITKE--NLAQA-V 2067
+E+ + +D + +++S TV AL QT + L +E ++ A +
Sbjct: 4819 RSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL 4878
Query: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLK-LKKELQSNKESVKSQMKQKDEDL--- 2123
E +A+ L VL DD +A R L D K K+L+ + + D L
Sbjct: 4879 EWLAEAEQTLRFHGVLPDD--EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAIC 4936
Query: 2124 ---------------ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ---VT 2165
R E+ + ++ + L L ++ LE + +Q T
Sbjct: 4937 HPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETT 4996
Query: 2166 LNKKDKEV-QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSD--AIQS- 2221
L KDKEV Q E + + + + F + M+ Q D D+V K ++R+ +D ++QS
Sbjct: 4997 LTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV---TKTYKRRAADPSSLQSH 5053
Query: 2222 ----KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK 2277
+ K S L Q I + ++N+ + +Q+W + +L
Sbjct: 5054 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL-LVSKWQQVWLLALERRRKL--- 5109
Query: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE-LKSLKDQLTDLSNSLEKCKEQKG 2336
+ L +LEE R + + K + K ++ D ++K ++ K
Sbjct: 5110 ---------NDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGK- 5159
Query: 2337 NLEGIIRQQEAD-IQNSKFSYEQLE 2360
I RQ+ D I +SKF +LE
Sbjct: 5160 ----ITRQEFIDGILSSKFPTSRLE 5180
Score = 68.9 bits (167), Expect = 8e-11
Identities = 263/1488 (17%), Positives = 567/1488 (38%), Gaps = 262/1488 (17%)
Query: 1900 QIQEELSRVTKLKETAEEEKDDLE--ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
QI++ L + + L + EE+ +++ + L+N + E+ + D T+ +ES
Sbjct: 612 QIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL-----DRTEWGSDLPSVESH 666
Query: 1958 M---KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
+ KN+ + + E E ++ + ++ + ++ Y EK+ + S +L
Sbjct: 667 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE------SQYAKLLNTS 720
Query: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
+ +++ + L R ++ L E + E D N+A+ ++ +
Sbjct: 721 RNQERHLDTLHNFVSRATNELIWLN------EKEEEEVAYDWSERNTNIARKKDYHAELM 774
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
EL + + Q A ++L +N + +++ + ++++Q +L Q E+H
Sbjct: 775 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQW-----SWILQLCQCVEQH 829
Query: 2135 LKEK-------KNMQEKLDALRREKVHLEETIG-EIQVTLNKKDKEVQQLQENLD----- 2181
+KE + +E D LR K ++ + +++K + VQ+ E +
Sbjct: 830 IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY 889
Query: 2182 -STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL-KEDNCSVLKDQ 2239
ST+ L K++ L + R D K ++ EI + K+D C + +
Sbjct: 890 KSTIANLMGKAKTIIQL---KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 946
Query: 2240 LR------------------------------QMSIHMEELKINISRLEHDKQI------ 2263
R ++ +E+ N+ L H+ I
Sbjct: 947 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVV 1006
Query: 2264 -WESKAQTEVQLQ----QKVCDTLQGENKELLSQ--------LEETRHLYHSSQNELAKL 2310
W +++ + L GE++++LS LE+++ S +++ +L
Sbjct: 1007 SWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 1066
Query: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE--------QLETD 2362
E E+ K +L S E+ +++ E + ++++N + E Q+ T
Sbjct: 1067 EKEVNVCKQYYQELLKSAEREEQE----ESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1122
Query: 2363 LQAS--RELTSRLHEEINMKEQ-----KIISLLSGK------EEAIQVAIAELRQQHDKE 2409
L+ E R+ E+ +K++ + ++ K + A ++ LR + +
Sbjct: 1123 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1182
Query: 2410 IKELENLLSQ-----EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
++ + + S ++ + + L +N +A + +L ET ++ I K +++ +
Sbjct: 1183 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 1242
Query: 2465 SMSSLQNDRD----------------RIVGD--YQQLEERHLSIILEK---DQLI---QE 2500
++ +++ D + + D ++ +ER L K DQL+ Q
Sbjct: 1243 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 1302
Query: 2501 AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560
+ + ++ G+ + LD + IQ E + I + + L QL
Sbjct: 1303 VHVQIDNRLRDLEGIGKSLKYYRDTYHPLD-DWIQQVETTQRKIQENQPENSKTLATQLN 1361
Query: 2561 QNK----ELENKYAKLEEKLKESEEANEDLR------RSFNALQEEKQDLSKEIESLKVS 2610
Q K E+E K +K++E K +E+ + ++ ++ A+ + +Q + ++ S
Sbjct: 1362 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1421
Query: 2611 ISQLTRQVTALQEEGT--LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
+ ++ L+ T + L +K + + RL +K + E ++E V KE
Sbjct: 1422 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL----EEEEKSLEEEKKEHVEKAKE 1477
Query: 2669 AAKKVGEIEDKLK---KELKHLHHDAGIMRNETETAEERVAELAR--DLVEMEQKLLMVT 2723
K V I LK K K I E T +E+++E + L + M
Sbjct: 1478 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1537
Query: 2724 KENKGLTAQIQS--------FGRSMSSLQNSRDHANEELD-----ELKRKYDASLKELAQ 2770
+E L Q+++ F S+ LQ S+ + +++ E +++Y L+ +
Sbjct: 1538 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1597
Query: 2771 L---KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
L E L+ + ++ + + + + + + E + + + L+++
Sbjct: 1598 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1657
Query: 2828 YNQVQSFSKAM-------ASLQNERDHLWNELEKFR---------KSEEGKQRSAAQPST 2871
++ KA+ A ++ E+ +L E K K E K + Q
Sbjct: 1658 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1717
Query: 2872 SPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE------ITELHPLKAQLQEYQ 2925
S ++++L +S++ D +R + K + +Q QE I E + L E
Sbjct: 1718 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-T 1776
Query: 2926 DKTKAFQIMQEELRQ--ENLSWQHE----LHQLRM--------------------EKSSW 2959
D QE L Q + + QHE HQ + EK
Sbjct: 1777 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1836
Query: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASP 3017
+ + + +K Y A+++ ++++ +L EL + + +Q Q A
Sbjct: 1837 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1896
Query: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQ---LCDTSQ 3074
D L+ + + ++ D + H+ +LR ++ N ++LE + S + DTS
Sbjct: 1897 DDINGLMTKLKRQKSFSEDVIS--HKGDLRYITISGN--RVLEAAKSCSKRDGGKVDTSA 1952
Query: 3075 SLRENQQ-------HYGDLLNHCAVLEKQVQEL----------QAGPL-NIDVAPGAPQE 3116
+ RE Q+ + L + C VL +++L G L + +
Sbjct: 1953 THREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK 2012
Query: 3117 KNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR 3164
DP+ L+ + Q Q+ + + V +L+K E D R
Sbjct: 2013 HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDAR 2060
Score = 33.9 bits (76), Expect = 2.7
Identities = 56/307 (18%), Positives = 134/307 (43%), Gaps = 24/307 (7%)
Query: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
N+ +L+Q R+ L + + + ++ E+ ++ ++L N +++ +L +E ++
Sbjct: 603 NSLQTLKLMQIRKPLLKSSLLDQNLTEE--EINMKFVQDLLNWVDEMQVQLDRTEWGSD- 659
Query: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
S + E +++ + IE + S+ + +++ +Q L L +A E++HRL
Sbjct: 660 -LPSVESHLENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYA------EKLHRLE 710
Query: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV 2705
+ ++ E L + ++ E+ +KE + + +D ++
Sbjct: 711 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 770
Query: 2706 AELARDLVEMEQKLLMVTK-------ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
AEL R+L + E+ + V + EN I+++ +M + + + +++
Sbjct: 771 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 830
Query: 2759 RKYDASLKELAQLKE-QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQL 2817
++ A + KE L +DA+ + + +S S+ LE L Q+ + + E+L
Sbjct: 831 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS----SIHKLEDLVQESMEEKEEL 886
Query: 2818 LHLSSQL 2824
L S +
Sbjct: 887 LQYKSTI 893
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 218 bits (554), Expect = 1e-55
Identities = 647/3338 (19%), Positives = 1330/3338 (39%), Gaps = 486/3338 (14%)
Query: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS 133
+L++++++L+EE+K K K+L+ +++++K +++ + G + S E++S
Sbjct: 1467 RLEEEEKSLEEEKKEHVEKAKELQKW----VSNISKTLKDAEKAGKPPFSKQKISSEEIS 1522
Query: 134 ------------------KH-DKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
KH DK + EE E+EK LQE L+ L Q Q Q
Sbjct: 1523 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL--FSESLKQLQESQ 1580
Query: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA-QQVVREKDARFETQVRLH 233
+ ++EE ++ ++Q QE +E + + L+QT+ Q+ D E +
Sbjct: 1581 TS-GDVKVEEKIVAERQ-QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1638
Query: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
+ E LQ Q + + + ++ + L+E+ E L + L++Q+L A+ + + L+
Sbjct: 1639 KQEELQKDMQGSAQA-LAEVVKNTENFLKENGEKLSQEDKA--LIEQKLNEAKIKCEQLN 1695
Query: 294 QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
+ +Q + E + + T E E ++++E E K NL + + ++ + E+AG
Sbjct: 1696 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLE----ESKTKIENLLDWLSNVDKDSERAG 1751
Query: 354 QAQAELESRYSALEQKHKA-----EMEEKTSHILSLQKTGQ------ELQSACDALKDQN 402
++ + Q+ E +E ++L GQ L +K Q+
Sbjct: 1752 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1811
Query: 403 SKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFL--NRLPLQQH-ETASQTSFPDV 457
K++ A QSAQ + LE Q Q S E + L N L+ H ETA S
Sbjct: 1812 EKIISQHQAVIIATQSAQVL--LEKQGQYLSPEEKEKLQKNMKELKVHYETALAES---- 1865
Query: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
E +T L+K + + L S ELE L+A + ++ +T L+ Q
Sbjct: 1866 --EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1923
Query: 518 GE-ADREVSEISIVDIANKR------SSSAEESGQ--------------DVLENTFSQKH 556
E ++ + I+ R S S + G+ D + F +
Sbjct: 1924 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1983
Query: 557 KELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLE 616
+ +VL +K+ ++ + G A E K + E + P ++ LE
Sbjct: 1984 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPIAVDPKNLQRQLE 2041
Query: 617 DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676
+T ++ + +Q + E +T+E L DA L K D K+L
Sbjct: 2042 ET----------KALQGQISSQQVAVEKLKKTAEV--LLDARGSLLPAKNDIQKTLD--- 2086
Query: 677 DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE--------- 727
DI ++D + + + +L++ ++ + + LDE + N+ ++E
Sbjct: 2087 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQD-GLDEMLDWMGNVESSLKEQGQVPLNST 2145
Query: 728 -----------FKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776
+++ S+ A++E+ + + + + S + L+A++K L +EA
Sbjct: 2146 ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM-ETTDPSTASSLQAKMKDLSARFSEA 2204
Query: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
+ + E+ + L T+ + ++ +E L +V + + + L
Sbjct: 2205 SHKHK---ETLAKMEELKTK-VELFENLSEKLQTFLETKTQALTEVDVPGKD----VTEL 2256
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQ--ALSQKELEITKMDQLLLEKKRDVETLQQ 894
+Q SE LE + + + S ++E+S S K L + K + L + + ++
Sbjct: 2257 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL----SKKFKEMED 2312
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
TI+EK + VT E+ + V +K+LK + E KK + + +
Sbjct: 2313 TIKEKKEAVTSCQ-----------EQLDAFQVLVKSLKSWIK-----ETTKKVPIVQPSF 2356
Query: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
+ L ++ ++ ++LQ ++ L E + K+ + I+ L+ V+ +
Sbjct: 2357 GAEDLGKSLEDT--------KKLQEKWSLKTPEIQ----KVNNSGISLCNLISAVTTPAK 2404
Query: 1015 ELANLKDES---KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
+A +K E + TE + + + ++ +++ + LK I+E
Sbjct: 2405 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT 2464
Query: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMN-----------QTLQDKTNQIDLLQAEISENQA 1120
+L ++K EE A + Q + K + ++ + Q +AE+ +N
Sbjct: 2465 KLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2524
Query: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
+Q+L T+ L++E P T + WK L E I + +E QL
Sbjct: 2525 KVQELKDKLTE--------LLEEN-----PDTPEAPRWKQMLTE-IDSKWQELNQLTIDR 2570
Query: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240
Q+ L L + Q E L++ L +++ + S + + Q +Q+QI +
Sbjct: 2571 QQKLEESSNNLTQFQTVEAQLKQWLVEKE----LMVSVLGPLSIDPNMLNTQRQQVQILL 2626
Query: 1241 RESIDGKLPSTDQQESCS----STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
+E K P +Q + S PG E+P + + V + W S + S
Sbjct: 2627 QEFATRK-PQYEQLTAAGQGILSRPG-EDPSLRGIVKEQLAAVTQK-----WDSLTGQLS 2679
Query: 1297 AL-----QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Q Q ++ L+ + + +L+ K+SS+ + T QL E K
Sbjct: 2680 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL-ETAQKMKQ 2738
Query: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
EI+ K A+ E L ++ L+ E R+L+ L + + K E V +L
Sbjct: 2739 EIQQEKKQIKVAQALCEDLSALVKEEYLKA---ELSRQLEGILKSFKDVEQKAENHVQHL 2795
Query: 1412 SG---------QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462
Q+S A + E + I A LE K+H + K L +
Sbjct: 2796 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-S 2854
Query: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN-----KSLQEELSLARGTIERLT 1517
M +K GE K Q K AAL + +K N K ++E + + ++E+
Sbjct: 2855 HMYEKTIAEGENLLLKTQGSEK--AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2912
Query: 1518 KSLADVESQV----SAQNK-----------EKDTVLGRLALLQEERDKLITEMDRSLLEN 1562
K VE+ QN E + + +L LQ+E D+ ++ LL N
Sbjct: 2913 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE--LLNN 2970
Query: 1563 --QSLSSSCESLKLALEGLTEDKEKLVKEI----ESLKSSKIA------ESTEWQEKHKE 1610
SL S CE K E +T++ + L++++ E L S K + E+QE KE
Sbjct: 2971 TANSLLSVCEIDK---EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3027
Query: 1611 LQKEYEIL---LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
+++ + L ++++ ++A +++ Q+K S +A K + + + A
Sbjct: 3028 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK--------SLQALKHQVDLAKRLA 3079
Query: 1668 EQEMEEMKEKMRKFAKSKQQKILELE---EENDRLRAEVHPAGDTAKECMETLLSSNASM 1724
+ + E + +K +L++E +E+ L +V D +ET L
Sbjct: 3080 QDLVVEASD-----SKGTSDVLLQVETIAQEHSTLSQQV----DEKCSFLETKLQGIGHF 3130
Query: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
+ + + ++ + S M+ +E +Q K I+ + K L A+ + N+T
Sbjct: 3131 QNTIREMFSQFAEFDDELDS-MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTC 3189
Query: 1785 ----VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
TEE + + G + ++LS C++ + A++ V +E + L+
Sbjct: 3190 KMMLATEETSPDLVGIKRDLEALSKQ----CNKLLDRAQAREEQVEGTIKRLEEFYSKLK 3245
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
+ L ++ EE + ++T+ + N + ++ K+ E++ LQ + +N L Q
Sbjct: 3246 EFSILLQKAEEHEESQGPVGMETETINQQLN--MFKVFQKE-EIEPLQGKQQDVNWLGQG 3302
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
+ + ++ T + E + DD+ R LN + + +A + + +++
Sbjct: 3303 LIQSAAKSTST-QGLEHDLDDVNARWKT----LNKKVAQRAAQLQEALLHCGRFQDALES 3357
Query: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
L + + EE LV + +E K+ AQ + K LQ LL +++
Sbjct: 3358 LLSWMVDTEE----LVANQKPPSAEF------KVVKAQIQ-----EQKLLQRLLDDRKST 3402
Query: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
V+ ++++ EKI+ ++ ++ S L+ E L E R + +L
Sbjct: 3403 VEVIKRE----GEKIATTAEPADKVKILKQLSL--LDSRWEALLNKAETRNR---QLEGI 3453
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEE-----KHL 2135
V+ E L + L ++ N E + +Q + +E + + ++ KHL
Sbjct: 3454 SVVAQQFH-ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3512
Query: 2136 KEKKNMQEKLDAL--RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
+ ++ + L L R +K ++ + QV + ++ E L + F +
Sbjct: 3513 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
Query: 2194 MSSLQDDRDRVIDEAKKWERK--FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
L + + V D+ K + ++ + ++ E+R+ +++ + K + Q ++ EL
Sbjct: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLEL- 3631
Query: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA--- 2308
+ + D+ + ++ + K L + + L Q + HS+ EL
Sbjct: 3632 --LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3689
Query: 2309 -KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-SKFSYEQLETDLQAS 2366
K+E EL S + Q+ + + + L+ + +A + + ++ S LE +
Sbjct: 3690 DKVEVELLSYETQVLK-GEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRA 3748
Query: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
RE ++ E N + + + ++ K E I AI LR Q + + E E E+ ++
Sbjct: 3749 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAI--LRSQQFDQAADAELSWITETEKKLM 3806
Query: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS------------MSSLQNDRD 2474
+ + D+T+ ++ KT E ++ K +D VKS S++ D
Sbjct: 3807 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLD 3866
Query: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534
+++ +Y + I E+ ++ A + N+ E L + + S ++L A +
Sbjct: 3867 KVLKNYDTI----CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPAL 3922
Query: 2535 QY------REDLNQV----------ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
+Y +E+ Q+ I + QLLE+ + ++ KY +
Sbjct: 3923 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY-- 3980
Query: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
+ ED+++ AL E ++ + + + L R V L++ ++ ++K +
Sbjct: 3981 -SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4039
Query: 2639 EE-------VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
E + +L L+ + ++R E+ K+ + K ++DKL + +
Sbjct: 4040 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA--VQDKLDQMV------- 4090
Query: 2692 GIMRNETETAEERVAELARDLVEMEQK-------LLMVTKENKGLTAQIQSFGRSMSSLQ 2744
I N EER A+L D++E+ +K L++ K+ + ++ G S ++
Sbjct: 4091 FIWENIHTLVEEREAKLL-DVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4149
Query: 2745 NSRDHA---NEELDELKRKYDASLKELAQL------KEQGLLNRERDALLSETAFSMNST 2795
++ A EE+D L+ + D + ++L ++ ++ + D L S S+N
Sbjct: 4150 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKA 4208
Query: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
++ + LE+ Q + + L + ++ + ++ S S L+ + + EL++F
Sbjct: 4209 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI-EELKQF 4267
Query: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH 2915
KSE +Q+ E++ L Q + +++TE
Sbjct: 4268 -KSEAYQQQI------------------------------EMERLNHQAELLLKKVTE-- 4294
Query: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975
++ QD +++ + L + ++ QH+L + Q+ A+
Sbjct: 4295 --ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG-----------QFQHALD 4341
Query: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035
+ L+H + L+ E + + ++++ + + Q+ V L
Sbjct: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL--AHQSTVEAVNKAGNDLI 4399
Query: 3036 DSL--KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVL 3093
+S +E + +++ LN + +LE+ QL +LR+ + +G++ + L
Sbjct: 4400 ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL---DGALRQAKGFHGEIEDLQQWL 4456
Query: 3094 EKQVQELQAGPLNIDVAPGAPQEKNGVHRK--SDPEELREPQQSFSEAQQQL-------- 3143
+ L A + P +E+ VH + + E E +S + QQ+
Sbjct: 4457 TDTERHLLASK-PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSA 4515
Query: 3144 -CNTRQEVNELRKLLE----EERDQRVAAENALSVAEE 3176
N Q++N L++ E + +++ E AL++A E
Sbjct: 4516 ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4553
Score = 204 bits (520), Expect = 9e-52
Identities = 660/3577 (18%), Positives = 1381/3577 (38%), Gaps = 604/3577 (16%)
Query: 37 ESDMEFNNTTQED-----VQERLAYAEQLVVELKDIIRQKDVQLQQKD--------EALQ 83
+S + N T+E+ VQ+ L + +++ V+L D+ + A++
Sbjct: 630 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 689
Query: 84 E-ERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK-HD--KSS 139
E E + KI ++++ A KLT K + +++Q +L T E L H+ +
Sbjct: 690 EFESSLKEAKISEIQMTAPLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 748
Query: 140 TEE-----EMEIEKIKHKLQEKEELISTLQ---AQLTQA--QAEQPAQSSTEMEEFVMMK 189
T E E E E++ + E+ I+ + A+L + Q E+ +S E+ E ++++
Sbjct: 749 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 808
Query: 190 QQLQEK--EEFISTLQAQLSQT-QAEQAAQQVVREKDARFE--------TQVRLHEDELL 238
E + + +Q Q S Q Q +Q ++E A FE T + + +
Sbjct: 809 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 868
Query: 239 QLVTQADVETEMQQKLRVLQRKLEEHEE---------SLVGRAQVV-------------- 275
Q D + + + ++Q +EE EE +L+G+A+ +
Sbjct: 869 QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKT 928
Query: 276 --------DLLQQELTAAEQRNQILSQQLQQM----------EAEHNTLRNTVETEREES 317
D Q E+T + +L+ + EA ++ TV +E+
Sbjct: 929 SIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEA 988
Query: 318 KILLEKMELEVAERKLSFHNLQEEM------HHLLEQFEQAGQAQAELESRYSALEQKHK 371
L ++E + +H M H+L+ + ++
Sbjct: 989 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRI------------------- 1029
Query: 372 AEMEEKTSHILSLQKT-GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
+ S++ S++ E Q L+ + L+D E V S I QLE ++
Sbjct: 1030 -----RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVC 1084
Query: 431 SKEISQFLNRLPL-QQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL 489
+ + L +Q E+ +V N + E+ Q R ++ +
Sbjct: 1085 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 1144
Query: 490 SSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV-- 547
E E+LK E E+L + + N+ E + + S V + ++ V
Sbjct: 1145 RITEQEKLKKELERLKDDLGTI--TNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYS 1202
Query: 548 LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQ--KEMKQMEGEG 605
+ +T+ K K ++++L + A+ + + +L + A AD ++ +KQ E
Sbjct: 1203 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE- 1261
Query: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665
+++ Q F + +E ++K +A ++ +T +E L
Sbjct: 1262 ---------VDEKRQVFHALEDE------LQKAKAISDEMFKTYKERDL----------- 1295
Query: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN---LDEKAKEISNLN 722
D D + + Q+ ++ +++ +LE K+ + Y LD+ +++
Sbjct: 1296 -DFDWHKEKADQLVERWQNVHVQIDNRLRDLE-GIGKSLKYYRDTYHPLDDWIQQVETTQ 1353
Query: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVK-ELSMVTELRAQVKQLEMNLAEAERQRR 781
+ I+E N NS ++ L+S+++ + S + E + +Q +
Sbjct: 1354 RKIQE---NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK------- 1403
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL--------- 832
DYE QT + + ++ + +++ E D++ +++ TL
Sbjct: 1404 -DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1462
Query: 833 --IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
++ L+ + ++ E E E E+ + + V +S+ L E ++
Sbjct: 1463 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1522
Query: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950
T ++ + E Q + +KM +EE+ L ++KTL+E NLL +E K+ Q
Sbjct: 1523 TKKEQLSEALQTIQLFLAKHGDKMT--DEERNELEKQVKTLQESYNLLF-SESLKQLQ-- 1577
Query: 951 EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL-LQRV 1009
+++ S +K ++ Q KE+LQ DLL + + +A +I + L++
Sbjct: 1578 -ESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY 1636
Query: 1010 SRLEEELANLKDESKKEIPLSET---------ERGE--VEEDKENKEYSEKCVTSKCQEI 1058
+EEL KD L+E E GE +EDK E KC+++
Sbjct: 1637 QSKQEELQ--KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1694
Query: 1059 EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN-QIDLLQAEISE 1117
+ +Q+ E + + K+ EK+AA +Q + ++ L +N D +A
Sbjct: 1695 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1754
Query: 1118 NQAIIQKLITSNTDASDGDSVALVKET-----VVISPPCTGSSEHWKPELEEKILALEKE 1172
Q I Q + T +GD + + E ++ G + L ++ ++ +
Sbjct: 1755 KQVIEQ----NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1810
Query: 1173 KEQLQKKLQE---ALTSRKAILKK-----AQEKERHLREELKQQKDDYNRLQEQFDEQSK 1224
E++ + Q A S + +L+K + E++ L++ +K+ K Y + +++ K
Sbjct: 1811 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK 1870
Query: 1225 ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
++ ++L + E S + E+ + L T+ + +
Sbjct: 1871 LTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM-------TKLKRQKSF 1923
Query: 1285 CPDWPSHSEDASALQ-GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343
D SH D + G V + + + KV+ +L ++ L
Sbjct: 1924 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1983
Query: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
+ N G ++ L E + L L++ + + +HL E + K + +
Sbjct: 1984 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS--KHLSE---PIAVDPKNLQR 2038
Query: 1404 KEEDVSYLSGQLSEKEAALTKIQ--TEII---------EQEDLIKALHT---QLEMQAKE 1449
+ E+ L GQ+S ++ A+ K++ E++ + D+ K L + E +K
Sbjct: 2039 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2098
Query: 1450 HDERIKQLQVELCEMKQKPEEIGE--------ESRAKQQIQRKLQAALISRKEALKENKS 1501
+ER ++LQ+ L + + E ES K+Q Q L + + ++ + +N
Sbjct: 2099 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--QDIISKNIM 2156
Query: 1502 LQEELSLARGTIERLTKSL------ADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
L+++++ + +I + + + D + S Q K KD + R + + + + +M
Sbjct: 2157 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKD-LSARFSEASHKHKETLAKM 2215
Query: 1556 DRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
+ + + + E L+ LE T+ + + K++ L ++E+ E K L+
Sbjct: 2216 EELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2275
Query: 1613 KEYEILLQ------------SYENVSNEAERIQHVVEAVRQEK-------------QELY 1647
+ +L + E +N +++ + + + ++++K Q L
Sbjct: 2276 VLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLV 2335
Query: 1648 GKLRS--TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR--LRAEV 1703
L+S E KK Q +++ + E +K + K E+++ N+ +
Sbjct: 2336 KSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL 2395
Query: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
A T + + + S A + E E +K S+ + +S +DL +
Sbjct: 2396 ISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455
Query: 1764 EGNVSK-QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
+ +++ L +K +++ + Q + + + PT +E+V + N
Sbjct: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKM---NKTATKWQQTPAPTDTEAVKTQVEQN 2512
Query: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF-------------------- 1862
K F + E+ + ++ +LK+++ L EE E
Sbjct: 2513 ----KSFEA--ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL 2566
Query: 1863 ----SQTLENEKNTLLSQISTKDGELKMLQEEVTKM-----------NLLN---QQIQEE 1904
Q LE N L+Q T + +LK E M N+LN QQ+Q
Sbjct: 2567 TIDRQQKLEESSNN-LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2625
Query: 1905 LSRVTKLKETAEE-------------EKDDLEERLMNQLA-------ELNGSIGNYCQDV 1944
L K E+ E L + QLA L G + + C +
Sbjct: 2626 LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWI 2685
Query: 1945 TDAQIKNELLESEMKNLKKCVSELEEE------------------------KQQLVKEKT 1980
A +K+ +S +++L +S+L+ + KQ++ +EK
Sbjct: 2686 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2745
Query: 1981 KVE----------SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
+++ + +++EYL+ Q E K +++ ++ + V+ LQ C
Sbjct: 2746 QIKVAQALCEDLSALVKEEYLKAELSRQLE----GILKSFKDVEQKAENHVQHLQSACAS 2801
Query: 2031 YQEKISALERTVKA-LEFVQTESQKDLEITK--ENLAQAVEHRKKAQAELASFKVLLDDT 2087
+ + R +A L+ + E K I+ + L ++ K L + + + T
Sbjct: 2802 -SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT 2860
Query: 2088 QSEAARVL-----ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
+E +L ++ L+ +L + K + + KQ E E +L+++ EK LK K+ ++
Sbjct: 2861 IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE-RENKLKESLEKALKYKEQVE 2919
Query: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKE-----VQQLQENLDSTVTQLAAFTKSMSSL 2197
+ + + +LE EI+ L+ + E ++ LQ+ +D + + +SL
Sbjct: 2920 TLWPWIDKCQNNLE----EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL 2975
Query: 2198 ----QDDRDRVIDEAKKWERK---FSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIH 2246
+ D++ V DE K +K ++ + SK E + ++ V K+ RQ+
Sbjct: 2976 LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 3035
Query: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQK----------------------------- 2277
E+L I+ S Q + +K T +Q QQK
Sbjct: 3036 KEQLDIHDSL---GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGT 3092
Query: 2278 -----VCDTLQGENKELLSQLEETRHLYHSS-------QNELAKLESELKSLKDQLTDLS 2325
+T+ E+ L Q++E + QN + ++ S+ D+L ++
Sbjct: 3093 SDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMA 3152
Query: 2326 ---NSLEKCKEQKGNLEGIIRQQE---ADIQNSKFSYEQLETDLQASRELT--SRLHEEI 2377
E ++QK ++ +++ E A N+ + + + + S +L R E +
Sbjct: 3153 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEAL 3212
Query: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV-- 2435
+ + K++ +EE ++ I L + + K +KE LL + EE EE++ V
Sbjct: 3213 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSK-LKEFSILLQKAEE-----HEESQGPVGM 3266
Query: 2436 --DKTNQLMETLKTIKKENI---QQKAQ---------LDSFVKSMSS--LQNDRDRIVGD 2479
+ NQ + K +KE I Q K Q + S KS S+ L++D D +
Sbjct: 3267 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNAR 3326
Query: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
++ L ++ + ++ +QEA + ++ + L S M D A +++
Sbjct: 3327 WKTLNKK----VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3382
Query: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR--RSFNALQEEK 2597
Q+ Q+++LL+ L K + EK+ + E + ++ + + L
Sbjct: 3383 KAQI------QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRW 3436
Query: 2598 QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
+ L + E+ + ++ V A Q TL + L E+ + + + + K
Sbjct: 3437 EALLNKAETRNRQLEGIS--VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK---- 3490
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
LEE++ Q +A +ED + KHLH I ++ + ++ + ++ Q
Sbjct: 3491 LEEQI--AQHKA------LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ 3542
Query: 2718 KLLMVTKENKGLTAQI--------QSFGRSMSSLQNSRDHANEELDELK-RKYDA----- 2763
+ +E +++ + FG L N + +++L +L + Y
Sbjct: 3543 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWK 3602
Query: 2764 SLKELAQLKEQGLLNRER--DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS 2821
EL L+E LL ++ ALL+ +T + L +KL + + ++ + + LS
Sbjct: 3603 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL-EAIKARYKDITKLS 3661
Query: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
+ + + Q ++ + S E +++E S E + + S + + LKK
Sbjct: 3662 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3721
Query: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
K K L +++ + EL P +A +E +K A + L +
Sbjct: 3722 E-----------AKNNKALLDSLNEVSSALLELVPWRA--REGLEKMVAEDNERYRLVSD 3768
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001
++ + E + +S + + L I++ +++L L ++ E +S+Q
Sbjct: 3769 TITQKVEEIDAAILRSQ---QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ---- 3821
Query: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL--------RIQQLNS 3053
+Q Q+ + E D +LV + T ++ K+ +K+L I Q+NS
Sbjct: 3822 -LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3880
Query: 3054 NFSQLLEEKNTLSIQLCDT------------------------SQSLRENQQHYGDLLNH 3089
LE +L Q +T ++LR+ Q+ + L
Sbjct: 3881 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3940
Query: 3090 CAVLEKQVQEL-QAGPLNIDVAPGAPQEKNGVHRKSD------PEELREPQQSFSEAQQQ 3142
A + + ++ + GP ++++PG + +D E++++ + EA Q
Sbjct: 3941 IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ 4000
Query: 3143 LCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
+++++ + L E +R+ ++S E+I+
Sbjct: 4001 STQFHDKIDQILESL-ERIVERLRQPPSISAEVEKIK 4036
Score = 176 bits (446), Expect = 3e-43
Identities = 620/3279 (18%), Positives = 1259/3279 (38%), Gaps = 588/3279 (17%)
Query: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER-KAADNKIKKLKLHAKAKLT 105
Q+D+Q ++V ++ +++ +L Q+D+AL E++ A K ++L L A+
Sbjct: 1644 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1703
Query: 106 SLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK-----SSTEEEMEIEKIKHK-------- 152
L+K + + + Q EE +K + S+ +++ E KHK
Sbjct: 1704 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGT 1763
Query: 153 ----------LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ-EKEEFIST 201
+ E++E+ L + + Q T E Q+++ + E+ IS
Sbjct: 1764 HFQEGDGKSAIGEEDEVNGNL------LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1817
Query: 202 LQAQLSQTQAEQAAQQVVREKDARF---ETQVRLHED--ELLQLVTQADVETEMQQKL-R 255
QA + TQ+ Q V+ EK ++ E + +L ++ EL A E+E + KL
Sbjct: 1818 HQAVIIATQSAQ----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 1873
Query: 256 VLQRKLEEHEESLVGRAQVVDLLQQEL----TAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
LQ +LE+ + + +QEL A+ N ++++ +Q + + + +
Sbjct: 1874 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1933
Query: 312 ------------------TEREESKILLEKMELEVAERKLS-----FHNLQEE------- 341
++R+ K+ EV +RKL F +L +
Sbjct: 1934 LRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-QRKLDHATDRFRSLYSKCNVLGNN 1992
Query: 342 MHHLLEQFEQAGQAQAELESRYSALE---QKHKAE------------MEEKTS---HILS 383
+ L+++++ A L + A E KH +E +EE + I S
Sbjct: 1993 LKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISS 2052
Query: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL 443
Q ++L+ + L D LL KN+ IQ+ D + + +++S+ +N
Sbjct: 2053 QQVAVEKLKKTAEVLLDARGSLLPAKND--------IQKTLDDIVGRYEDLSKSVNERNE 2104
Query: 444 QQHETASQT-SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
+ T +++ S D +E + N+ S K E+G + L+S L+++ ++N
Sbjct: 2105 KLQITLTRSLSVQDGLDEMLDWMG--NVESSLK-------EQGQVPLNSTALQDIISKNI 2155
Query: 503 KLSSQITLLEAQ-NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
L I ++ N E ++ E + D + S A+ + S KHKE
Sbjct: 2156 MLEQDIAGRQSSINAMNEKVKKFMETT--DPSTASSLQAKMKDLSARFSEASHKHKETLA 2213
Query: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
+ E+K E L +LQ + + + +++ G ++ +++++ +
Sbjct: 2214 KMEELKTKVELFENLSEKLQTFLETKT-------QALTEVDVPGKDVTELSQYMQESTSE 2266
Query: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
F L ++ KE +S H + + + L K K+ D + C
Sbjct: 2267 FLEHKKHLEVLHSLLKEISS--HGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2324
Query: 682 HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA 741
Q++L+ Q+L L + + + + + +L + +E+ KK + S
Sbjct: 2325 -QEQLDAF--QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPE 2381
Query: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHS 800
+ + + +S +S VT + ++ A + + E A+ L + +
Sbjct: 2382 IQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2441
Query: 801 LSIEAKSKDV------KIEVLQNELDDVQLQFSEQSTLIRSLQSQL-------------- 840
I +D+ KI L +L +Q E S +++ LQ
Sbjct: 2442 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2501
Query: 841 ---------QNK--ESEVLEGAERVRHISSKVEEL-------------SQALSQKELEIT 876
QNK E+E+ + +V+ + K+ EL Q L++ + +
Sbjct: 2502 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQ 2561
Query: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV---------E 927
+++QL +++ QQ +EE +T+ + L E++ + V
Sbjct: 2562 ELNQLTIDR-------QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2614
Query: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ---HEFDLL 984
+ T ++Q+ +L + +K Q E+ G+ E I KE+L ++D L
Sbjct: 2615 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2674
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS----------ETER 1034
+ R + A++ + + L ++L++L ++ + +S ET +
Sbjct: 2675 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2734
Query: 1035 GEVEEDKENKEYSEKCVTSKCQEI-----EIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
+E ++ K+ K + C+++ E YLK +S + + KD+E+K AE
Sbjct: 2735 KMKQEIQQEKKQI-KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQK--AENH 2791
Query: 1090 FQALVK------QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Q L Q Q +D +D + E +++ I KL + L+K+
Sbjct: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES---------LIKD 2842
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEK----EKEQLQKKLQEALTSRKAILKKAQEKER 1199
S T S ++ + E L K EK LQ +L T+ K+ +E+E
Sbjct: 2843 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2902
Query: 1200 HLREEL------KQQKDDY--------NRLQE-QFDEQSKENENIGDQLRQLQ------- 1237
L+E L K+Q + N L+E +F E EN +L+ LQ
Sbjct: 2903 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2962
Query: 1238 --IQVRESIDGKLPST---DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPS-- 1290
+++ + L S D++ L + + TEQ H++ N+ +
Sbjct: 2963 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3022
Query: 1291 -------------------HSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV------ 1325
H S + ++ Q K ++A K +++L
Sbjct: 3023 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3082
Query: 1326 ------SSTTSELTKKSEEVFQ----LQEQINK---------QGL--------------- 1351
S TS++ + E + Q L +Q+++ QG+
Sbjct: 3083 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3142
Query: 1352 ----EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
E++S+ V +AE +LQ++ E+ + + LE L ++ K++ EE
Sbjct: 3143 EFDDELDSMAPVGRDAE----TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3198
Query: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE---RIKQLQVELCEM 1464
L G + EA L+K +++ D +A Q+E K +E ++K+ + L +
Sbjct: 3199 SPDLVGIKRDLEA-LSKQCNKLL---DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3254
Query: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS-LARGTIERLTKS---- 1519
++ E G + I ++L + +KE ++ + Q++++ L +G I+ KS
Sbjct: 3255 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3314
Query: 1520 -----LADVESQVSAQNKEKDTVLGRLALLQE--------------------ERDKLITE 1554
L DV ++ NK+ V R A LQE + ++L+
Sbjct: 3315 GLEHDLDDVNARWKTLNKK---VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3371
Query: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
E + + + + KL L+ L +D++ V+ I+ + KIA + E +K K L K+
Sbjct: 3372 QKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKR-EGEKIATTAEPADKVKIL-KQ 3428
Query: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR-------------------STEA 1655
+L +E + N+AE +E + Q+ + L T+A
Sbjct: 3429 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3488
Query: 1656 NKKETEKQLQEAEQE--MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC 1713
+K E + +A ++ + K + + + K+L E+ D +++++ + E
Sbjct: 3489 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3548
Query: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQAN 1772
E S + +++ L K+ E + L D LS+ VQD + EG +Q+
Sbjct: 3549 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGLWKQQSE 3606
Query: 1773 LEATE-----KHDNQTNVTEEGTQSIPGETEEQ--------DSLSMSTRPTCSESVPSAK 1819
L + + N G + + T ++ +++ + S AK
Sbjct: 3607 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
Query: 1820 SANPAVS---KDFSSHDEINNYLQQID-----------------QLKERIAGLEEEKQKN 1859
+ A+ + S+H+E+ +L +++ Q + R L++E + N
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726
Query: 1860 KEFSQTLENEKNTLLSQIS--TKDGELKMLQEEVTKMNLLNQQIQEELSRVTK--LKETA 1915
K +L + LL + ++G KM+ E+ + L++ I +++ + L+
Sbjct: 3727 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3786
Query: 1916 EEEKDDLEERLMNQLAELNGSIGNYC--QDVTDAQIK-NELLESEMKNLKKCVSELEEEK 1972
++ D E + + + S+G+ QD T AQ++ + E+ K + +L +
Sbjct: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
Query: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ 2032
+++ ++ E + K+ L+K+ K + + + QL+ R Q
Sbjct: 3847 HKIMTACSEEEKQSMKKKLDKV------------LKNYDTICQINSERYLQLE----RAQ 3890
Query: 2033 EKISALERTVKALEFVQTESQKDLE------ITKENLAQAVEHRKKAQAELASFKVLLDD 2086
++ T + L TE+Q + + E L Q E ++ + +A K +D
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3950
Query: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLD 2146
++L + +Q + + Q ED+++R +E + + +K+D
Sbjct: 3951 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEA-ISQSTQFHDKID 4009
Query: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206
+ + E + + + +K +Q+ EN + +V
Sbjct: 4010 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSV---------------------- 4047
Query: 2207 EAKKWERKFSDAIQSKEEEIRL-----KEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
+ +K + + Q EE I K+ + ++D+L QM E NI L ++
Sbjct: 4048 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE----NIHTLVEER 4103
Query: 2262 QIWESKAQTEVQLQQKV-CDTLQ-----GENKELLSQLEETR---HLYHSSQNELAKLES 2312
E+K ++L +K CD + + ++ + LE+ + Q +
Sbjct: 4104 ---EAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4160
Query: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS---------KFSYEQLETDL 2363
E+ L+++L + N + G + I ++ D NS K ++LE +
Sbjct: 4161 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4220
Query: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE 2423
QA+ + L + + ++G + A I + ++I+EL+ S+ ++
Sbjct: 4221 QAAVQYQDGLQAVFDWVD------IAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQ 4274
Query: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
I +E N +A +L+ LK + +E+ + Q D ++ + +RI+ +L
Sbjct: 4275 QIEMERLNHQA-----ELL--LKKVTEESDKHTVQ-DPLMELKLIWDSLEERIINRQHKL 4326
Query: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
E L++ Q A E GL S + + ++ EL ++ N V
Sbjct: 4327 EGALLAL-----GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
Query: 2544 ITIKDSQQ------KQLLEVQL-QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
+ + + + L+E ++ L+NK L ++ + E E ++ + +
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTL-GLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
+ EIE L+ ++ R + A + G L QL V E A + + +
Sbjct: 4442 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4501
Query: 2656 AELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD---- 2711
+ ++ L K A + + + LK++ + + NE +T E LA +
Sbjct: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVE----TKLNERKTKLEEALNLAMEFHNS 4557
Query: 2712 -------LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
L + EQ L + ++ + L + H E++ EL K
Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH-REQIIELD-KTGTH 4615
Query: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
LK +Q ++ L+ ++ L+S S EK+ Q+L+ + L
Sbjct: 4616 LKYFSQKQDVVLI---KNLLISVQ------------SRWEKVVQRLVER-------GRSL 4653
Query: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
+D+ + + F +A + L W LE+ KS + + A P ++ K+
Sbjct: 4654 DDARKRAKQFHEAWSKLME-----W--LEESEKSLDSELEIANDPDKIKTQLAQHKEFQK 4706
Query: 2885 SL---------QNDRDRLLKELKNLQQQYLQINQEITEL 2914
SL N R LKE +L L+++ ++EL
Sbjct: 4707 SLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4745
Score = 156 bits (395), Expect = 3e-37
Identities = 482/2513 (19%), Positives = 1005/2513 (39%), Gaps = 376/2513 (14%)
Query: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA---QLTQAQAEQ--PA 176
L + S +S H + ++ +K+K ++Q++++ I QA L+ E+ A
Sbjct: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA 2768
Query: 177 QSSTEMEEFVMMKQQLQEK-EEFISTLQ-AQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
+ S ++E + + +++K E + LQ A S Q +Q ++ D + E Q + H
Sbjct: 2769 ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP 2828
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
+ KL VL+ +++H++ + E T AE N +L
Sbjct: 2829 ---------------ISAKLDVLESLIKDHKD--FSKTLTAQSHMYEKTIAEGENLLLKT 2871
Query: 295 QLQQ---MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQ 351
Q + ++ + NT++ +T ++ K K++ E E+ L + E + +++ +
Sbjct: 2872 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLK-ESLEKALKYKEQVETLWPWIDKCQN 2930
Query: 352 AGQA------QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405
+ AE E+ + L+ K EM++ + L T L S C+ K+ +
Sbjct: 2931 NLEEIKFCLDPAEGENSIAKLKSLQK-EMDQHFGMVELLNNTANSLLSVCEIDKE----V 2985
Query: 406 LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465
+ D+N+ +Q + + +QL K + + + Q V
Sbjct: 2986 VTDENKSLIQK---VDMVTEQLHSKKFCLENMTQKF------------------KEFQEV 3024
Query: 466 TEENIASLQ--KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
++E+ LQ K +++ + G+ S+ L L+ + + L +A + +
Sbjct: 3025 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-------QALKHQVDLAKR 3077
Query: 524 VSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581
+++ +V+ ++ + +S DVL T +Q+H LS ++ E+ +FL+ +LQ
Sbjct: 3078 LAQDLVVEASDSKGTS------DVLLQVETIAQEHSTLS------QQVDEKCSFLETKLQ 3125
Query: 582 G-KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE-- 638
G + E+ Q E + +AP+ G+D + ++ ++ A K+
Sbjct: 3126 GIGHFQNTIREMFSQFAEFDDELDSMAPV---------GRDAETLQKQKETIKAFLKKLE 3176
Query: 639 --QASTEHQSRTSEE-ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
AS ++ ++T + ++ + +L K+D L A+ QC++ L+R +++ +
Sbjct: 3177 ALMASNDNANKTCKMMLATEETSPDLVGIKRD----LEALSK--QCNK-LLDRAQAREEQ 3229
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755
+E + +E Y K KE S L Q EE +++ +E +Q L+ K
Sbjct: 3230 VEGTIKRLEEFYSK-----LKEFSILLQKAEEHEES----QGPVGMETETINQQLNMFKV 3280
Query: 756 LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815
Q KQ ++N Q + +++ L + ++ K+ + K+
Sbjct: 3281 FQKEEIEPLQGKQQDVNWLG---QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
Query: 816 QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG---AERVRHISSKVEELSQALSQKE 872
+L + L + SL S + + E V + + + ++++E Q L Q+
Sbjct: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE--QKLLQRL 3395
Query: 873 LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932
L+ K ++ KR+ E + T E D+ + +++ L+ +L + +T
Sbjct: 3396 LDDRKSTVEVI--KREGEKIATTAEPADK------VKILKQLSLLDSRWEALLNKAETRN 3447
Query: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG-QISKEELQHEFDLLKKENEQR 991
QL +S + E +E NE + +++ P G Q SK E E +
Sbjct: 3448 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE----------EQIAQ 3497
Query: 992 KRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV---EEDKENKEYSE 1048
+ L+ +IN + L + + + L L K++ S+ + +V E +++ SE
Sbjct: 3498 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3557
Query: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA----EEQFQALVKQMNQTLQDK 1104
+ C + E EVEL + ++ +KL+ + + L KQ ++ +
Sbjct: 3558 LLQQALCNA------KIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL---R 3608
Query: 1105 TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP----CTGSSEHWKP 1160
Q D+L + + +QA++ L + GD V ++++ + T S
Sbjct: 3609 VLQEDILLRKQNVDQALLNGL--ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
Query: 1161 ELEEKILA---LEKEKEQL----QKKLQEALTSRKAILKKAQEKERHLR-EELKQQKDDY 1212
LE+ + L E+L K E L+ +LK + + +R +ELK++ +
Sbjct: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726
Query: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE----SCSSTPGLEEPLF 1268
L + +E S L + + RE ++ K+ + D + S + T +EE
Sbjct: 3727 KALLDSLNEVSSA------LLELVPWRAREGLE-KMVAEDNERYRLVSDTITQKVEEIDA 3779
Query: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ--IKAQLKEIEAEKVELELKVS 1326
++ L W + +E G + Q AQL+ + +E+ L+
Sbjct: 3780 AILRSQQFDQAADAEL--SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI-LRHK 3836
Query: 1327 STTSELTKKSEEVFQLQEQINKQGLEIES---LKTVSHEAEVHAESLQQKLESSQLQIAG 1383
+L K ++ + KQ ++ + LK ++++E Q + L
Sbjct: 3837 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQF 3896
Query: 1384 LEHLRELQPKLDELQKLISK-------------KEEDVSYLSGQLSEKEAALTK------ 1424
E EL P L E Q +IS+ ++E+ L ++E + + K
Sbjct: 3897 WETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3956
Query: 1425 ------------IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ---LQVELCEMKQKPE 1469
IQ + + + L + ++ +A DE I Q ++ ++ + E
Sbjct: 3957 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4016
Query: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
I E R I +++ KE + ENK++ ++ + E L + ++ ++
Sbjct: 4017 RIVERLRQPPSISAEVEKI----KEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4072
Query: 1530 QNKEKDTV-----LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
+K+ L ++ + E L+ E + LL+ L+ ++L +D +
Sbjct: 4073 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4132
Query: 1585 KLVKEIES--LKSSKIAESTEWQEKHKE----LQKEYEILLQ-SYENVSNEAERIQHVVE 1637
++++E + S + + E E +E LQ+E +I++ E ++ E + +V+
Sbjct: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
Query: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
E + L K+ +L+EA Q + ++ + Q + + +
Sbjct: 4193 KSIDELNSAWDSLNKAW---KDRIDKLEEAMQAAVQYQDGL--------QAVFDWVDIAG 4241
Query: 1698 RLRAEVHPAG---DTAKECMETL--LSSNASMKE-ELERVKMEYETLSKKFQS------- 1744
A + P G +T K+ +E L S A ++ E+ER+ + E L KK
Sbjct: 4242 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4301
Query: 1745 ---LMSEK---DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPG 1795
LM K DSL E + + +H++EG + + EG Q G
Sbjct: 4302 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361
Query: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSK------DFSSHDEINNYLQQIDQLKERI 1849
+ + ++ V + +S AV+K + S+ +E +N +++ L +R
Sbjct: 4362 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4421
Query: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK----------MNLLNQ 1899
+ E+ ++ K+ + + L Q GE++ LQ+ +T + L +
Sbjct: 4422 QNVLEKTEQRKQ-------QLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474
Query: 1900 QIQEELS---RVTKLKETAEEEKDDLEERLMNQLAELNGSIG-NYCQDVTDAQIKNELLE 1955
+E+L+ V E EE L ++ LA S N QD+ + + K E +E
Sbjct: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4534
Query: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+++ K ++LEE ++ ++ +++ + A++ S + + +
Sbjct: 4535 TKLNERK---TKLEEALNLAMEFHNSLQ-----DFINWLTQAEQTLNVASRPSLILDTVL 4586
Query: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR-KKAQ 2074
+ E K + ++E+I L++T L++ SQK + +NL +V+ R +K
Sbjct: 4587 FQIDEHKVFANEVNSHREQIIELDKTGTHLKYF---SQKQDVVLIKNLLISVQSRWEKVV 4643
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
L LDD + A + KL + L+ +++S+ S+++ ++ + + + A+ K
Sbjct: 4644 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4703
Query: 2135 LKEKKNMQEKL-DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
++ + + D R L+E L K D + +L++ D+ +
Sbjct: 4704 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSV----- 4757
Query: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEE-----EIRLKE---------------DNC 2233
+R ++EA + +F+DA+Q+ + E +L E DN
Sbjct: 4758 ------ERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4811
Query: 2234 SVLKDQLRQMSIHMEELKINISRL---EHDKQIWESKAQTEVQLQ-QKVCD---TLQGEN 2286
+ +L + + ++ LK + L D W E+ + + VC + Q
Sbjct: 4812 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4871
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
+ L Q EE + H+ LA+ E L+ L D ++L +Q + ++
Sbjct: 4872 EAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKR 4930
Query: 2347 ADIQNS--------KFSYEQLETDLQASRELTSRLHEEI----NMKEQKIISLLSG---K 2391
A++ + + T ++ + EE+ +Q++ S L+G K
Sbjct: 4931 AELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4990
Query: 2392 EEAIQVAIAELR------QQHDKEI--KELENLLSQEEEENIVLEEENKKAVD 2436
+E ++ +A L+ DKE+ +E+E + + E +EE +K D
Sbjct: 4991 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD 5043
Score = 129 bits (324), Expect = 5e-29
Identities = 476/2605 (18%), Positives = 1047/2605 (40%), Gaps = 386/2605 (14%)
Query: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQE------RLAYAEQLVVELKDIIRQK--D 72
D D + + L H ++ + T Q+ QE ++ A+ L +L +++++
Sbjct: 2708 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2767
Query: 73 VQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132
+L ++ E + + K + K + H ++ S +++ ++M L T+ EEQ
Sbjct: 2768 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF-QQMSRDFQAWLDTK--KEEQN 2824
Query: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192
H S+ +++ ++ +++ ++ TL AQ M ++ +
Sbjct: 2825 KSHPISA-----KLDVLESLIKDHKDFSKTLTAQSH------------------MYEKTI 2861
Query: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252
E E + L+ Q S+ A Q ++ F QV+ E++L + + +A + ++
Sbjct: 2862 AEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA---LKYKE 2916
Query: 253 KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN--QILSQQLQQMEAEHNTLRNTV 310
++ L +++ + +L +D + E + A+ ++ + + Q +E +NT + +
Sbjct: 2917 QVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2976
Query: 311 -------ETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG-QAQAELESR 362
E +E+K L++K+++ V E+ S E M ++F++ +++ +L+
Sbjct: 2977 SVCEIDKEVVTDENKSLIQKVDM-VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 3035
Query: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS------ 416
L+ + ++ L++ +T Q+ A D +L QD +A S
Sbjct: 3036 KEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV 3095
Query: 417 ---AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE-ENIAS 472
+TI Q L Q+ E FL Q Q + +++++ + E +++A
Sbjct: 3096 LLQVETIAQEHSTLSQQVDEKCSFLETK--LQGIGHFQNTIREMFSQFAEFDDELDSMAP 3153
Query: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE----ADREVSEIS 528
+ + L+ +K + +LE L A N+ + ++ A T R++ +S
Sbjct: 3154 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3213
Query: 529 -----IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
++D A R E + + + E F K KE S+LL + +E +E + ++ +
Sbjct: 3214 KQCNKLLDRAQAREEQVEGTIKRLEE--FYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
Query: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
+ +V ++E++ ++G+ + + GQ + +S +E +
Sbjct: 3272 NQQLNMFKVFQKEEIEPLQGK-------QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVN 3324
Query: 644 HQSRTSEE------ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD------ELERLKS 691
+ +T + L +A + + + LS + D + + E + +K+
Sbjct: 3325 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA 3384
Query: 692 QILELEL------NFHKAQEIYEKNLDEKA------------KEISNLNQLIEEFKKNAD 733
QI E +L + E+ ++ ++ A K++S L+ E A+
Sbjct: 3385 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3444
Query: 734 NNSSAFTALSEERDQLLSQVKELS-MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
+ +S Q ++ L+ +T + ++ E +A + + + D+
Sbjct: 3445 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3504
Query: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
++ H + + +K+ + + D VQ + +Q + ++ SE+L+ A
Sbjct: 3505 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR-SELLQQAL 3563
Query: 853 RVRHISSKVE-ELSQALSQKELEITKMD------QLLLEKKRDVETLQQTIEEKDQQVTE 905
I + E EL L++ +++K+ + L +++ ++ LQ+ I + Q V +
Sbjct: 3564 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3623
Query: 906 ISFSMTEKMVQLN-EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
+ E + Q +E + +++ +K + +++ + +E+ +++ L ++
Sbjct: 3624 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3683
Query: 965 EMSP-AGQISKEELQHEFDLLKKEN----EQRKRKLQAALINRKELLQRVSRLEEELANL 1019
E+ ++ E L +E +LK E + R ++L+ N K LL ++ + L L
Sbjct: 3684 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3743
Query: 1020 KDESKKEIPLSETERGE--VEEDKENKEYSEKCVTSKCQEIEIYL---KQTISEKEVELQ 1074
+P E E V ED E +T K +EI+ + +Q + EL
Sbjct: 3744 -------VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS 3796
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQ-DKTNQIDLLQAEISENQAIIQKLITSN---- 1129
I + E+KL + + Q + LQ KT +++L+ ++ II L+ S
Sbjct: 3797 WIT-ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR-----HKDIIDDLVKSGHKIM 3850
Query: 1130 TDASDGDSVALVKETVVI----SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
T S+ + ++ K+ + C +SE + E+ +L + + ++L LT
Sbjct: 3851 TACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL--ERAQSLVNQFWETYEELWPWLT 3908
Query: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI---GDQLRQLQIQVRE 1242
++I+ + E L+QQ++++ +L+E E + + G QL +L
Sbjct: 3909 ETQSIISQLPAPALEY-ETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3967
Query: 1243 SIDGKLPSTD------QQESCSSTPGLEEPLFKATEQHHT-QPVLESNLCPDWPSHSEDA 1295
SI K + D +++ L+E + ++T+ H +LES
Sbjct: 3968 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES------------- 4014
Query: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ---EQINKQGLE 1352
+ +I +L++ + E+E K+ SE S ++ +LQ E + ++G E
Sbjct: 4015 --------LERIVERLRQPPSISAEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4065
Query: 1353 IESLKTVSHEAEVHAESLQQKLESS-----------QLQIAGLEHLRELQPKL--DELQK 1399
+ + ++ + ++ A+++Q KL+ + + A L + EL K D +
Sbjct: 4066 MIA-RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4124
Query: 1400 LISKKE--------EDVSYLSGQLSEKEAALTKIQTEII---EQEDLIKALHTQLEMQAK 1448
+++ K+ ED + +++ A I+ EI E+ D++ L ++L
Sbjct: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG 4184
Query: 1449 EHDERIKQLQVELCEM---------KQKPEEIGEESRAKQQIQRKLQAA----------- 1488
E D+ I + ++ K + +++ E +A Q Q LQA
Sbjct: 4185 EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4244
Query: 1489 ---------LISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV-- 1537
L + K+ ++E K + E + +ERL A++ + + +K TV
Sbjct: 4245 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEESDKHTVQD 4303
Query: 1538 -LGRLALLQEERDKLIT----EMDRSLLENQSLSSSCESLKLAL---EGLTEDKEKL--- 1586
L L L+ + ++ I +++ +LL + + L L EGL +++ +
Sbjct: 4304 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4363
Query: 1587 --VKEIESLK---------------------SSKIAESTEWQEKHKELQKEYEILLQSYE 1623
EIE K + + ES+ +E LQ + E+L Q ++
Sbjct: 4364 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA-SNLQNKLEVLNQRWQ 4422
Query: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
NV + E+ + ++ ++ + +G++ + +TE+ L A + + + E ++
Sbjct: 4423 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL-ASKPLGGLPETAKEQLN 4481
Query: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
+ E + + ++ + C + S+ ++ +++ +K ++E++ K
Sbjct: 4482 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPK---SAETNIDQDINNLKEKWESVETK-- 4536
Query: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQAN-LEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
++E+ + EE +L + ++ N L E+ N + ++ + +E
Sbjct: 4537 --LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594
Query: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI-----------NNYLQQIDQLKERIAG 1851
+ + + K+ K FS ++ + + + + +L ER
Sbjct: 4595 FANEVNSHREQIIELDKTGTHL--KYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4652
Query: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ--EEVTKMNLLNQQIQEELSRVT 1909
L++ +++ K+F + L + D EL++ +++ +++ Q+ L
Sbjct: 4653 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4712
Query: 1910 KLKETAEEEKDDLEE---------RLMNQLAELNGSIGNYCQDVTDAQIKNE---LLESE 1957
+ +T L+E +L + L+EL C + Q K E L +
Sbjct: 4713 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4772
Query: 1958 MKN-LKKCVSELEEEKQQLVKEK-TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+ L+ + L + QL +++ + ++ ++ + QKE G ++ + + LK
Sbjct: 4773 FTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS---VQALK 4829
Query: 2016 EKQQEVKQLQKDCIRY----QEKISALERTVKALEF-VQTESQKDLEITKE--NLAQA-V 2067
+E+ + +D + +++S TV AL QT + L +E ++ A +
Sbjct: 4830 RSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL 4889
Query: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLK-LKKELQSNKESVKSQMKQKDEDL--- 2123
E +A+ L VL DD +A R L D K K+L+ + + D L
Sbjct: 4890 EWLAEAEQTLRFHGVLPDD--EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAIC 4947
Query: 2124 ---------------ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ---VT 2165
R E+ + ++ + L L ++ LE + +Q T
Sbjct: 4948 HPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETT 5007
Query: 2166 LNKKDKEV-QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSD--AIQS- 2221
L KDKEV Q E + + + + F + M+ Q D D+V K ++R+ +D ++QS
Sbjct: 5008 LTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV---TKTYKRRAADPSSLQSH 5064
Query: 2222 ----KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK 2277
+ K S L Q I + ++N+ + +Q+W + +L
Sbjct: 5065 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL-LVSKWQQVWLLALERRRKL--- 5120
Query: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE-LKSLKDQLTDLSNSLEKCKEQKG 2336
+ L +LEE R + + K + K ++ D ++K ++ K
Sbjct: 5121 ---------NDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGK- 5170
Query: 2337 NLEGIIRQQEAD-IQNSKFSYEQLE 2360
I RQ+ D I +SKF +LE
Sbjct: 5171 ----ITRQEFIDGILSSKFPTSRLE 5191
Score = 68.9 bits (167), Expect = 8e-11
Identities = 263/1488 (17%), Positives = 567/1488 (38%), Gaps = 262/1488 (17%)
Query: 1900 QIQEELSRVTKLKETAEEEKDDLE--ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
QI++ L + + L + EE+ +++ + L+N + E+ + D T+ +ES
Sbjct: 623 QIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL-----DRTEWGSDLPSVESH 677
Query: 1958 M---KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
+ KN+ + + E E ++ + ++ + ++ Y EK+ + S +L
Sbjct: 678 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE------SQYAKLLNTS 731
Query: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
+ +++ + L R ++ L E + E D N+A+ ++ +
Sbjct: 732 RNQERHLDTLHNFVSRATNELIWLN------EKEEEEVAYDWSERNTNIARKKDYHAELM 785
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
EL + + Q A ++L +N + +++ + ++++Q +L Q E+H
Sbjct: 786 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQW-----SWILQLCQCVEQH 840
Query: 2135 LKEK-------KNMQEKLDALRREKVHLEETIG-EIQVTLNKKDKEVQQLQENLD----- 2181
+KE + +E D LR K ++ + +++K + VQ+ E +
Sbjct: 841 IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY 900
Query: 2182 -STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL-KEDNCSVLKDQ 2239
ST+ L K++ L + R D K ++ EI + K+D C + +
Sbjct: 901 KSTIANLMGKAKTIIQL---KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 957
Query: 2240 LR------------------------------QMSIHMEELKINISRLEHDKQI------ 2263
R ++ +E+ N+ L H+ I
Sbjct: 958 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVV 1017
Query: 2264 -WESKAQTEVQLQ----QKVCDTLQGENKELLSQ--------LEETRHLYHSSQNELAKL 2310
W +++ + L GE++++LS LE+++ S +++ +L
Sbjct: 1018 SWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 1077
Query: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE--------QLETD 2362
E E+ K +L S E+ +++ E + ++++N + E Q+ T
Sbjct: 1078 EKEVNVCKQYYQELLKSAEREEQE----ESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1133
Query: 2363 LQAS--RELTSRLHEEINMKEQ-----KIISLLSGK------EEAIQVAIAELRQQHDKE 2409
L+ E R+ E+ +K++ + ++ K + A ++ LR + +
Sbjct: 1134 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1193
Query: 2410 IKELENLLSQ-----EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
++ + + S ++ + + L +N +A + +L ET ++ I K +++ +
Sbjct: 1194 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 1253
Query: 2465 SMSSLQNDRD----------------RIVGD--YQQLEERHLSIILEK---DQLI---QE 2500
++ +++ D + + D ++ +ER L K DQL+ Q
Sbjct: 1254 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 1313
Query: 2501 AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560
+ + ++ G+ + LD + IQ E + I + + L QL
Sbjct: 1314 VHVQIDNRLRDLEGIGKSLKYYRDTYHPLD-DWIQQVETTQRKIQENQPENSKTLATQLN 1372
Query: 2561 QNK----ELENKYAKLEEKLKESEEANEDLR------RSFNALQEEKQDLSKEIESLKVS 2610
Q K E+E K +K++E K +E+ + ++ ++ A+ + +Q + ++ S
Sbjct: 1373 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1432
Query: 2611 ISQLTRQVTALQEEGT--LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
+ ++ L+ T + L +K + + RL +K + E ++E V KE
Sbjct: 1433 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL----EEEEKSLEEEKKEHVEKAKE 1488
Query: 2669 AAKKVGEIEDKLK---KELKHLHHDAGIMRNETETAEERVAELAR--DLVEMEQKLLMVT 2723
K V I LK K K I E T +E+++E + L + M
Sbjct: 1489 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1548
Query: 2724 KENKGLTAQIQS--------FGRSMSSLQNSRDHANEELD-----ELKRKYDASLKELAQ 2770
+E L Q+++ F S+ LQ S+ + +++ E +++Y L+ +
Sbjct: 1549 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1608
Query: 2771 L---KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
L E L+ + ++ + + + + + + E + + + L+++
Sbjct: 1609 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1668
Query: 2828 YNQVQSFSKAM-------ASLQNERDHLWNELEKFR---------KSEEGKQRSAAQPST 2871
++ KA+ A ++ E+ +L E K K E K + Q
Sbjct: 1669 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1728
Query: 2872 SPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE------ITELHPLKAQLQEYQ 2925
S ++++L +S++ D +R + K + +Q QE I E + L E
Sbjct: 1729 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-T 1787
Query: 2926 DKTKAFQIMQEELRQ--ENLSWQHE----LHQLRM--------------------EKSSW 2959
D QE L Q + + QHE HQ + EK
Sbjct: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1847
Query: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASP 3017
+ + + +K Y A+++ ++++ +L EL + + +Q Q A
Sbjct: 1848 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1907
Query: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQ---LCDTSQ 3074
D L+ + + ++ D + H+ +LR ++ N ++LE + S + DTS
Sbjct: 1908 DDINGLMTKLKRQKSFSEDVIS--HKGDLRYITISGN--RVLEAAKSCSKRDGGKVDTSA 1963
Query: 3075 SLRENQQ-------HYGDLLNHCAVLEKQVQEL----------QAGPL-NIDVAPGAPQE 3116
+ RE Q+ + L + C VL +++L G L + +
Sbjct: 1964 THREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK 2023
Query: 3117 KNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR 3164
DP+ L+ + Q Q+ + + V +L+K E D R
Sbjct: 2024 HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDAR 2071
Score = 33.9 bits (76), Expect = 2.7
Identities = 56/307 (18%), Positives = 134/307 (43%), Gaps = 24/307 (7%)
Query: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
N+ +L+Q R+ L + + + ++ E+ ++ ++L N +++ +L +E ++
Sbjct: 614 NSLQTLKLMQIRKPLLKSSLLDQNLTEE--EINMKFVQDLLNWVDEMQVQLDRTEWGSD- 670
Query: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
S + E +++ + IE + S+ + +++ +Q L L +A E++HRL
Sbjct: 671 -LPSVESHLENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYA------EKLHRLE 721
Query: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV 2705
+ ++ E L + ++ E+ +KE + + +D ++
Sbjct: 722 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781
Query: 2706 AELARDLVEMEQKLLMVTK-------ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
AEL R+L + E+ + V + EN I+++ +M + + + +++
Sbjct: 782 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841
Query: 2759 RKYDASLKELAQLKE-QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQL 2817
++ A + KE L +DA+ + + +S S+ LE L Q+ + + E+L
Sbjct: 842 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS----SIHKLEDLVQESMEEKEEL 897
Query: 2818 LHLSSQL 2824
L S +
Sbjct: 898 LQYKSTI 904
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 218 bits (554), Expect = 1e-55
Identities = 647/3338 (19%), Positives = 1330/3338 (39%), Gaps = 486/3338 (14%)
Query: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS 133
+L++++++L+EE+K K K+L+ +++++K +++ + G + S E++S
Sbjct: 1605 RLEEEEKSLEEEKKEHVEKAKELQKW----VSNISKTLKDAEKAGKPPFSKQKISSEEIS 1660
Query: 134 ------------------KH-DKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
KH DK + EE E+EK LQE L+ L Q Q Q
Sbjct: 1661 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL--FSESLKQLQESQ 1718
Query: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA-QQVVREKDARFETQVRLH 233
+ ++EE ++ ++Q QE +E + + L+QT+ Q+ D E +
Sbjct: 1719 TS-GDVKVEEKIVAERQ-QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1776
Query: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
+ E LQ Q + + + ++ + L+E+ E L + L++Q+L A+ + + L+
Sbjct: 1777 KQEELQKDMQGSAQA-LAEVVKNTENFLKENGEKLSQEDKA--LIEQKLNEAKIKCEQLN 1833
Query: 294 QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
+ +Q + E + + T E E ++++E E K NL + + ++ + E+AG
Sbjct: 1834 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLE----ESKTKIENLLDWLSNVDKDSERAG 1889
Query: 354 QAQAELESRYSALEQKHKA-----EMEEKTSHILSLQKTGQ------ELQSACDALKDQN 402
++ + Q+ E +E ++L GQ L +K Q+
Sbjct: 1890 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1949
Query: 403 SKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFL--NRLPLQQH-ETASQTSFPDV 457
K++ A QSAQ + LE Q Q S E + L N L+ H ETA S
Sbjct: 1950 EKIISQHQAVIIATQSAQVL--LEKQGQYLSPEEKEKLQKNMKELKVHYETALAES---- 2003
Query: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
E +T L+K + + L S ELE L+A + ++ +T L+ Q
Sbjct: 2004 --EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 2061
Query: 518 GE-ADREVSEISIVDIANKR------SSSAEESGQ--------------DVLENTFSQKH 556
E ++ + I+ R S S + G+ D + F +
Sbjct: 2062 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 2121
Query: 557 KELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLE 616
+ +VL +K+ ++ + G A E K + E + P ++ LE
Sbjct: 2122 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPIAVDPKNLQRQLE 2179
Query: 617 DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676
+T ++ + +Q + E +T+E L DA L K D K+L
Sbjct: 2180 ET----------KALQGQISSQQVAVEKLKKTAEV--LLDARGSLLPAKNDIQKTLD--- 2224
Query: 677 DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE--------- 727
DI ++D + + + +L++ ++ + + LDE + N+ ++E
Sbjct: 2225 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQD-GLDEMLDWMGNVESSLKEQGQVPLNST 2283
Query: 728 -----------FKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776
+++ S+ A++E+ + + + + S + L+A++K L +EA
Sbjct: 2284 ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM-ETTDPSTASSLQAKMKDLSARFSEA 2342
Query: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
+ + E+ + L T+ + ++ +E L +V + + + L
Sbjct: 2343 SHKHK---ETLAKMEELKTK-VELFENLSEKLQTFLETKTQALTEVDVPGKD----VTEL 2394
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQ--ALSQKELEITKMDQLLLEKKRDVETLQQ 894
+Q SE LE + + + S ++E+S S K L + K + L + + ++
Sbjct: 2395 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL----SKKFKEMED 2450
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
TI+EK + VT E+ + V +K+LK + E KK + + +
Sbjct: 2451 TIKEKKEAVTSCQ-----------EQLDAFQVLVKSLKSWIK-----ETTKKVPIVQPSF 2494
Query: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
+ L ++ ++ ++LQ ++ L E + K+ + I+ L+ V+ +
Sbjct: 2495 GAEDLGKSLEDT--------KKLQEKWSLKTPEIQ----KVNNSGISLCNLISAVTTPAK 2542
Query: 1015 ELANLKDES---KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
+A +K E + TE + + + ++ +++ + LK I+E
Sbjct: 2543 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT 2602
Query: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMN-----------QTLQDKTNQIDLLQAEISENQA 1120
+L ++K EE A + Q + K + ++ + Q +AE+ +N
Sbjct: 2603 KLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2662
Query: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
+Q+L T+ L++E P T + WK L E I + +E QL
Sbjct: 2663 KVQELKDKLTE--------LLEEN-----PDTPEAPRWKQMLTE-IDSKWQELNQLTIDR 2708
Query: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240
Q+ L L + Q E L++ L +++ + S + + Q +Q+QI +
Sbjct: 2709 QQKLEESSNNLTQFQTVEAQLKQWLVEKE----LMVSVLGPLSIDPNMLNTQRQQVQILL 2764
Query: 1241 RESIDGKLPSTDQQESCS----STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
+E K P +Q + S PG E+P + + V + W S + S
Sbjct: 2765 QEFATRK-PQYEQLTAAGQGILSRPG-EDPSLRGIVKEQLAAVTQK-----WDSLTGQLS 2817
Query: 1297 AL-----QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Q Q ++ L+ + + +L+ K+SS+ + T QL E K
Sbjct: 2818 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL-ETAQKMKQ 2876
Query: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
EI+ K A+ E L ++ L+ E R+L+ L + + K E V +L
Sbjct: 2877 EIQQEKKQIKVAQALCEDLSALVKEEYLKA---ELSRQLEGILKSFKDVEQKAENHVQHL 2933
Query: 1412 SG---------QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462
Q+S A + E + I A LE K+H + K L +
Sbjct: 2934 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-S 2992
Query: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN-----KSLQEELSLARGTIERLT 1517
M +K GE K Q K AAL + +K N K ++E + + ++E+
Sbjct: 2993 HMYEKTIAEGENLLLKTQGSEK--AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 3050
Query: 1518 KSLADVESQV----SAQNK-----------EKDTVLGRLALLQEERDKLITEMDRSLLEN 1562
K VE+ QN E + + +L LQ+E D+ ++ LL N
Sbjct: 3051 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE--LLNN 3108
Query: 1563 --QSLSSSCESLKLALEGLTEDKEKLVKEI----ESLKSSKIA------ESTEWQEKHKE 1610
SL S CE K E +T++ + L++++ E L S K + E+QE KE
Sbjct: 3109 TANSLLSVCEIDK---EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3165
Query: 1611 LQKEYEIL---LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
+++ + L ++++ ++A +++ Q+K S +A K + + + A
Sbjct: 3166 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK--------SLQALKHQVDLAKRLA 3217
Query: 1668 EQEMEEMKEKMRKFAKSKQQKILELE---EENDRLRAEVHPAGDTAKECMETLLSSNASM 1724
+ + E + +K +L++E +E+ L +V D +ET L
Sbjct: 3218 QDLVVEASD-----SKGTSDVLLQVETIAQEHSTLSQQV----DEKCSFLETKLQGIGHF 3268
Query: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
+ + + ++ + S M+ +E +Q K I+ + K L A+ + N+T
Sbjct: 3269 QNTIREMFSQFAEFDDELDS-MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTC 3327
Query: 1785 ----VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
TEE + + G + ++LS C++ + A++ V +E + L+
Sbjct: 3328 KMMLATEETSPDLVGIKRDLEALSKQ----CNKLLDRAQAREEQVEGTIKRLEEFYSKLK 3383
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
+ L ++ EE + ++T+ + N + ++ K+ E++ LQ + +N L Q
Sbjct: 3384 EFSILLQKAEEHEESQGPVGMETETINQQLN--MFKVFQKE-EIEPLQGKQQDVNWLGQG 3440
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
+ + ++ T + E + DD+ R LN + + +A + + +++
Sbjct: 3441 LIQSAAKSTST-QGLEHDLDDVNARWKT----LNKKVAQRAAQLQEALLHCGRFQDALES 3495
Query: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
L + + EE LV + +E K+ AQ + K LQ LL +++
Sbjct: 3496 LLSWMVDTEE----LVANQKPPSAEF------KVVKAQIQ-----EQKLLQRLLDDRKST 3540
Query: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
V+ ++++ EKI+ ++ ++ S L+ E L E R + +L
Sbjct: 3541 VEVIKRE----GEKIATTAEPADKVKILKQLSL--LDSRWEALLNKAETRNR---QLEGI 3591
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEE-----KHL 2135
V+ E L + L ++ N E + +Q + +E + + ++ KHL
Sbjct: 3592 SVVAQQFH-ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3650
Query: 2136 KEKKNMQEKLDAL--RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
+ ++ + L L R +K ++ + QV + ++ E L + F +
Sbjct: 3651 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3710
Query: 2194 MSSLQDDRDRVIDEAKKWERK--FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
L + + V D+ K + ++ + ++ E+R+ +++ + K + Q ++ EL
Sbjct: 3711 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLEL- 3769
Query: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA--- 2308
+ + D+ + ++ + K L + + L Q + HS+ EL
Sbjct: 3770 --LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3827
Query: 2309 -KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-SKFSYEQLETDLQAS 2366
K+E EL S + Q+ + + + L+ + +A + + ++ S LE +
Sbjct: 3828 DKVEVELLSYETQVLK-GEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRA 3886
Query: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
RE ++ E N + + + ++ K E I AI LR Q + + E E E+ ++
Sbjct: 3887 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAI--LRSQQFDQAADAELSWITETEKKLM 3944
Query: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS------------MSSLQNDRD 2474
+ + D+T+ ++ KT E ++ K +D VKS S++ D
Sbjct: 3945 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLD 4004
Query: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534
+++ +Y + I E+ ++ A + N+ E L + + S ++L A +
Sbjct: 4005 KVLKNYDTI----CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPAL 4060
Query: 2535 QY------REDLNQV----------ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
+Y +E+ Q+ I + QLLE+ + ++ KY +
Sbjct: 4061 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY-- 4118
Query: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
+ ED+++ AL E ++ + + + L R V L++ ++ ++K +
Sbjct: 4119 -SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 4177
Query: 2639 EE-------VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
E + +L L+ + ++R E+ K+ + K ++DKL + +
Sbjct: 4178 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA--VQDKLDQMV------- 4228
Query: 2692 GIMRNETETAEERVAELARDLVEMEQK-------LLMVTKENKGLTAQIQSFGRSMSSLQ 2744
I N EER A+L D++E+ +K L++ K+ + ++ G S ++
Sbjct: 4229 FIWENIHTLVEEREAKLL-DVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4287
Query: 2745 NSRDHA---NEELDELKRKYDASLKELAQL------KEQGLLNRERDALLSETAFSMNST 2795
++ A EE+D L+ + D + ++L ++ ++ + D L S S+N
Sbjct: 4288 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKA 4346
Query: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
++ + LE+ Q + + L + ++ + ++ S S L+ + + EL++F
Sbjct: 4347 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI-EELKQF 4405
Query: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH 2915
KSE +Q+ E++ L Q + +++TE
Sbjct: 4406 -KSEAYQQQI------------------------------EMERLNHQAELLLKKVTE-- 4432
Query: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975
++ QD +++ + L + ++ QH+L + Q+ A+
Sbjct: 4433 --ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG-----------QFQHALD 4479
Query: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035
+ L+H + L+ E + + ++++ + + Q+ V L
Sbjct: 4480 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL--AHQSTVEAVNKAGNDLI 4537
Query: 3036 DSL--KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVL 3093
+S +E + +++ LN + +LE+ QL +LR+ + +G++ + L
Sbjct: 4538 ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL---DGALRQAKGFHGEIEDLQQWL 4594
Query: 3094 EKQVQELQAGPLNIDVAPGAPQEKNGVHRK--SDPEELREPQQSFSEAQQQL-------- 3143
+ L A + P +E+ VH + + E E +S + QQ+
Sbjct: 4595 TDTERHLLASK-PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSA 4653
Query: 3144 -CNTRQEVNELRKLLE----EERDQRVAAENALSVAEE 3176
N Q++N L++ E + +++ E AL++A E
Sbjct: 4654 ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4691
Score = 204 bits (520), Expect = 9e-52
Identities = 660/3577 (18%), Positives = 1381/3577 (38%), Gaps = 604/3577 (16%)
Query: 37 ESDMEFNNTTQED-----VQERLAYAEQLVVELKDIIRQKDVQLQQKD--------EALQ 83
+S + N T+E+ VQ+ L + +++ V+L D+ + A++
Sbjct: 768 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 827
Query: 84 E-ERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK-HD--KSS 139
E E + KI ++++ A KLT K + +++Q +L T E L H+ +
Sbjct: 828 EFESSLKEAKISEIQMTAPLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 886
Query: 140 TEE-----EMEIEKIKHKLQEKEELISTLQ---AQLTQA--QAEQPAQSSTEMEEFVMMK 189
T E E E E++ + E+ I+ + A+L + Q E+ +S E+ E ++++
Sbjct: 887 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 946
Query: 190 QQLQEK--EEFISTLQAQLSQT-QAEQAAQQVVREKDARFE--------TQVRLHEDELL 238
E + + +Q Q S Q Q +Q ++E A FE T + + +
Sbjct: 947 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 1006
Query: 239 QLVTQADVETEMQQKLRVLQRKLEEHEE---------SLVGRAQVV-------------- 275
Q D + + + ++Q +EE EE +L+G+A+ +
Sbjct: 1007 QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKT 1066
Query: 276 --------DLLQQELTAAEQRNQILSQQLQQM----------EAEHNTLRNTVETEREES 317
D Q E+T + +L+ + EA ++ TV +E+
Sbjct: 1067 SIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEA 1126
Query: 318 KILLEKMELEVAERKLSFHNLQEEM------HHLLEQFEQAGQAQAELESRYSALEQKHK 371
L ++E + +H M H+L+ + ++
Sbjct: 1127 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRI------------------- 1167
Query: 372 AEMEEKTSHILSLQKT-GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
+ S++ S++ E Q L+ + L+D E V S I QLE ++
Sbjct: 1168 -----RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVC 1222
Query: 431 SKEISQFLNRLPL-QQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL 489
+ + L +Q E+ +V N + E+ Q R ++ +
Sbjct: 1223 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 1282
Query: 490 SSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV-- 547
E E+LK E E+L + + N+ E + + S V + ++ V
Sbjct: 1283 RITEQEKLKKELERLKDDLGTI--TNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYS 1340
Query: 548 LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQ--KEMKQMEGEG 605
+ +T+ K K ++++L + A+ + + +L + A AD ++ +KQ E
Sbjct: 1341 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE- 1399
Query: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665
+++ Q F + +E ++K +A ++ +T +E L
Sbjct: 1400 ---------VDEKRQVFHALEDE------LQKAKAISDEMFKTYKERDL----------- 1433
Query: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN---LDEKAKEISNLN 722
D D + + Q+ ++ +++ +LE K+ + Y LD+ +++
Sbjct: 1434 -DFDWHKEKADQLVERWQNVHVQIDNRLRDLE-GIGKSLKYYRDTYHPLDDWIQQVETTQ 1491
Query: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVK-ELSMVTELRAQVKQLEMNLAEAERQRR 781
+ I+E N NS ++ L+S+++ + S + E + +Q +
Sbjct: 1492 RKIQE---NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK------- 1541
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL--------- 832
DYE QT + + ++ + +++ E D++ +++ TL
Sbjct: 1542 -DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1600
Query: 833 --IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
++ L+ + ++ E E E E+ + + V +S+ L E ++
Sbjct: 1601 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1660
Query: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950
T ++ + E Q + +KM +EE+ L ++KTL+E NLL +E K+ Q
Sbjct: 1661 TKKEQLSEALQTIQLFLAKHGDKMT--DEERNELEKQVKTLQESYNLLF-SESLKQLQ-- 1715
Query: 951 EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL-LQRV 1009
+++ S +K ++ Q KE+LQ DLL + + +A +I + L++
Sbjct: 1716 -ESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY 1774
Query: 1010 SRLEEELANLKDESKKEIPLSET---------ERGE--VEEDKENKEYSEKCVTSKCQEI 1058
+EEL KD L+E E GE +EDK E KC+++
Sbjct: 1775 QSKQEELQ--KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1832
Query: 1059 EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN-QIDLLQAEISE 1117
+ +Q+ E + + K+ EK+AA +Q + ++ L +N D +A
Sbjct: 1833 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1892
Query: 1118 NQAIIQKLITSNTDASDGDSVALVKET-----VVISPPCTGSSEHWKPELEEKILALEKE 1172
Q I Q + T +GD + + E ++ G + L ++ ++ +
Sbjct: 1893 KQVIEQ----NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1948
Query: 1173 KEQLQKKLQE---ALTSRKAILKK-----AQEKERHLREELKQQKDDYNRLQEQFDEQSK 1224
E++ + Q A S + +L+K + E++ L++ +K+ K Y + +++ K
Sbjct: 1949 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK 2008
Query: 1225 ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
++ ++L + E S + E+ + L T+ + +
Sbjct: 2009 LTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM-------TKLKRQKSF 2061
Query: 1285 CPDWPSHSEDASALQ-GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343
D SH D + G V + + + KV+ +L ++ L
Sbjct: 2062 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 2121
Query: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
+ N G ++ L E + L L++ + + +HL E + K + +
Sbjct: 2122 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS--KHLSE---PIAVDPKNLQR 2176
Query: 1404 KEEDVSYLSGQLSEKEAALTKIQ--TEII---------EQEDLIKALHT---QLEMQAKE 1449
+ E+ L GQ+S ++ A+ K++ E++ + D+ K L + E +K
Sbjct: 2177 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2236
Query: 1450 HDERIKQLQVELCEMKQKPEEIGE--------ESRAKQQIQRKLQAALISRKEALKENKS 1501
+ER ++LQ+ L + + E ES K+Q Q L + + ++ + +N
Sbjct: 2237 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--QDIISKNIM 2294
Query: 1502 LQEELSLARGTIERLTKSL------ADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
L+++++ + +I + + + D + S Q K KD + R + + + + +M
Sbjct: 2295 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKD-LSARFSEASHKHKETLAKM 2353
Query: 1556 DRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
+ + + + E L+ LE T+ + + K++ L ++E+ E K L+
Sbjct: 2354 EELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2413
Query: 1613 KEYEILLQ------------SYENVSNEAERIQHVVEAVRQEK-------------QELY 1647
+ +L + E +N +++ + + + ++++K Q L
Sbjct: 2414 VLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLV 2473
Query: 1648 GKLRS--TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR--LRAEV 1703
L+S E KK Q +++ + E +K + K E+++ N+ +
Sbjct: 2474 KSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL 2533
Query: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
A T + + + S A + E E +K S+ + +S +DL +
Sbjct: 2534 ISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2593
Query: 1764 EGNVSK-QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
+ +++ L +K +++ + Q + + + PT +E+V + N
Sbjct: 2594 KDKIAELNTKLSKLQKAQEESSAMMQWLQKM---NKTATKWQQTPAPTDTEAVKTQVEQN 2650
Query: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF-------------------- 1862
K F + E+ + ++ +LK+++ L EE E
Sbjct: 2651 ----KSFEA--ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL 2704
Query: 1863 ----SQTLENEKNTLLSQISTKDGELKMLQEEVTKM-----------NLLN---QQIQEE 1904
Q LE N L+Q T + +LK E M N+LN QQ+Q
Sbjct: 2705 TIDRQQKLEESSNN-LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2763
Query: 1905 LSRVTKLKETAEE-------------EKDDLEERLMNQLA-------ELNGSIGNYCQDV 1944
L K E+ E L + QLA L G + + C +
Sbjct: 2764 LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWI 2823
Query: 1945 TDAQIKNELLESEMKNLKKCVSELEEE------------------------KQQLVKEKT 1980
A +K+ +S +++L +S+L+ + KQ++ +EK
Sbjct: 2824 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2883
Query: 1981 KVE----------SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
+++ + +++EYL+ Q E K +++ ++ + V+ LQ C
Sbjct: 2884 QIKVAQALCEDLSALVKEEYLKAELSRQLE----GILKSFKDVEQKAENHVQHLQSACAS 2939
Query: 2031 YQEKISALERTVKA-LEFVQTESQKDLEITK--ENLAQAVEHRKKAQAELASFKVLLDDT 2087
+ + R +A L+ + E K I+ + L ++ K L + + + T
Sbjct: 2940 -SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT 2998
Query: 2088 QSEAARVL-----ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
+E +L ++ L+ +L + K + + KQ E E +L+++ EK LK K+ ++
Sbjct: 2999 IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE-RENKLKESLEKALKYKEQVE 3057
Query: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKE-----VQQLQENLDSTVTQLAAFTKSMSSL 2197
+ + + +LE EI+ L+ + E ++ LQ+ +D + + +SL
Sbjct: 3058 TLWPWIDKCQNNLE----EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL 3113
Query: 2198 ----QDDRDRVIDEAKKWERK---FSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIH 2246
+ D++ V DE K +K ++ + SK E + ++ V K+ RQ+
Sbjct: 3114 LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 3173
Query: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQK----------------------------- 2277
E+L I+ S Q + +K T +Q QQK
Sbjct: 3174 KEQLDIHDSL---GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGT 3230
Query: 2278 -----VCDTLQGENKELLSQLEETRHLYHSS-------QNELAKLESELKSLKDQLTDLS 2325
+T+ E+ L Q++E + QN + ++ S+ D+L ++
Sbjct: 3231 SDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMA 3290
Query: 2326 ---NSLEKCKEQKGNLEGIIRQQE---ADIQNSKFSYEQLETDLQASRELT--SRLHEEI 2377
E ++QK ++ +++ E A N+ + + + + S +L R E +
Sbjct: 3291 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEAL 3350
Query: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV-- 2435
+ + K++ +EE ++ I L + + K +KE LL + EE EE++ V
Sbjct: 3351 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSK-LKEFSILLQKAEE-----HEESQGPVGM 3404
Query: 2436 --DKTNQLMETLKTIKKENI---QQKAQ---------LDSFVKSMSS--LQNDRDRIVGD 2479
+ NQ + K +KE I Q K Q + S KS S+ L++D D +
Sbjct: 3405 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNAR 3464
Query: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
++ L ++ + ++ +QEA + ++ + L S M D A +++
Sbjct: 3465 WKTLNKK----VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3520
Query: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR--RSFNALQEEK 2597
Q+ Q+++LL+ L K + EK+ + E + ++ + + L
Sbjct: 3521 KAQI------QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRW 3574
Query: 2598 QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
+ L + E+ + ++ V A Q TL + L E+ + + + + K
Sbjct: 3575 EALLNKAETRNRQLEGIS--VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK---- 3628
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
LEE++ Q +A +ED + KHLH I ++ + ++ + ++ Q
Sbjct: 3629 LEEQI--AQHKA------LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ 3680
Query: 2718 KLLMVTKENKGLTAQI--------QSFGRSMSSLQNSRDHANEELDELK-RKYDA----- 2763
+ +E +++ + FG L N + +++L +L + Y
Sbjct: 3681 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWK 3740
Query: 2764 SLKELAQLKEQGLLNRER--DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS 2821
EL L+E LL ++ ALL+ +T + L +KL + + ++ + + LS
Sbjct: 3741 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL-EAIKARYKDITKLS 3799
Query: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
+ + + Q ++ + S E +++E S E + + S + + LKK
Sbjct: 3800 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3859
Query: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
K K L +++ + EL P +A +E +K A + L +
Sbjct: 3860 E-----------AKNNKALLDSLNEVSSALLELVPWRA--REGLEKMVAEDNERYRLVSD 3906
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001
++ + E + +S + + L I++ +++L L ++ E +S+Q
Sbjct: 3907 TITQKVEEIDAAILRSQ---QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ---- 3959
Query: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL--------RIQQLNS 3053
+Q Q+ + E D +LV + T ++ K+ +K+L I Q+NS
Sbjct: 3960 -LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 4018
Query: 3054 NFSQLLEEKNTLSIQLCDT------------------------SQSLRENQQHYGDLLNH 3089
LE +L Q +T ++LR+ Q+ + L
Sbjct: 4019 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 4078
Query: 3090 CAVLEKQVQEL-QAGPLNIDVAPGAPQEKNGVHRKSD------PEELREPQQSFSEAQQQ 3142
A + + ++ + GP ++++PG + +D E++++ + EA Q
Sbjct: 4079 IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ 4138
Query: 3143 LCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
+++++ + L E +R+ ++S E+I+
Sbjct: 4139 STQFHDKIDQILESL-ERIVERLRQPPSISAEVEKIK 4174
Score = 176 bits (446), Expect = 3e-43
Identities = 620/3279 (18%), Positives = 1259/3279 (38%), Gaps = 588/3279 (17%)
Query: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER-KAADNKIKKLKLHAKAKLT 105
Q+D+Q ++V ++ +++ +L Q+D+AL E++ A K ++L L A+
Sbjct: 1782 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1841
Query: 106 SLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK-----SSTEEEMEIEKIKHK-------- 152
L+K + + + Q EE +K + S+ +++ E KHK
Sbjct: 1842 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGT 1901
Query: 153 ----------LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ-EKEEFIST 201
+ E++E+ L + + Q T E Q+++ + E+ IS
Sbjct: 1902 HFQEGDGKSAIGEEDEVNGNL------LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1955
Query: 202 LQAQLSQTQAEQAAQQVVREKDARF---ETQVRLHED--ELLQLVTQADVETEMQQKL-R 255
QA + TQ+ Q V+ EK ++ E + +L ++ EL A E+E + KL
Sbjct: 1956 HQAVIIATQSAQ----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 2011
Query: 256 VLQRKLEEHEESLVGRAQVVDLLQQEL----TAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
LQ +LE+ + + +QEL A+ N ++++ +Q + + + +
Sbjct: 2012 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 2071
Query: 312 ------------------TEREESKILLEKMELEVAERKLS-----FHNLQEE------- 341
++R+ K+ EV +RKL F +L +
Sbjct: 2072 LRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-QRKLDHATDRFRSLYSKCNVLGNN 2130
Query: 342 MHHLLEQFEQAGQAQAELESRYSALE---QKHKAE------------MEEKTS---HILS 383
+ L+++++ A L + A E KH +E +EE + I S
Sbjct: 2131 LKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISS 2190
Query: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL 443
Q ++L+ + L D LL KN+ IQ+ D + + +++S+ +N
Sbjct: 2191 QQVAVEKLKKTAEVLLDARGSLLPAKND--------IQKTLDDIVGRYEDLSKSVNERNE 2242
Query: 444 QQHETASQT-SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
+ T +++ S D +E + N+ S K E+G + L+S L+++ ++N
Sbjct: 2243 KLQITLTRSLSVQDGLDEMLDWMG--NVESSLK-------EQGQVPLNSTALQDIISKNI 2293
Query: 503 KLSSQITLLEAQ-NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
L I ++ N E ++ E + D + S A+ + S KHKE
Sbjct: 2294 MLEQDIAGRQSSINAMNEKVKKFMETT--DPSTASSLQAKMKDLSARFSEASHKHKETLA 2351
Query: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
+ E+K E L +LQ + + + +++ G ++ +++++ +
Sbjct: 2352 KMEELKTKVELFENLSEKLQTFLETKT-------QALTEVDVPGKDVTELSQYMQESTSE 2404
Query: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
F L ++ KE +S H + + + L K K+ D + C
Sbjct: 2405 FLEHKKHLEVLHSLLKEISS--HGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2462
Query: 682 HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA 741
Q++L+ Q+L L + + + + + +L + +E+ KK + S
Sbjct: 2463 -QEQLDAF--QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPE 2519
Query: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHS 800
+ + + +S +S VT + ++ A + + E A+ L + +
Sbjct: 2520 IQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2579
Query: 801 LSIEAKSKDV------KIEVLQNELDDVQLQFSEQSTLIRSLQSQL-------------- 840
I +D+ KI L +L +Q E S +++ LQ
Sbjct: 2580 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2639
Query: 841 ---------QNK--ESEVLEGAERVRHISSKVEEL-------------SQALSQKELEIT 876
QNK E+E+ + +V+ + K+ EL Q L++ + +
Sbjct: 2640 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQ 2699
Query: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV---------E 927
+++QL +++ QQ +EE +T+ + L E++ + V
Sbjct: 2700 ELNQLTIDR-------QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2752
Query: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ---HEFDLL 984
+ T ++Q+ +L + +K Q E+ G+ E I KE+L ++D L
Sbjct: 2753 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2812
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS----------ETER 1034
+ R + A++ + + L ++L++L ++ + +S ET +
Sbjct: 2813 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2872
Query: 1035 GEVEEDKENKEYSEKCVTSKCQEI-----EIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
+E ++ K+ K + C+++ E YLK +S + + KD+E+K AE
Sbjct: 2873 KMKQEIQQEKKQI-KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQK--AENH 2929
Query: 1090 FQALVK------QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Q L Q Q +D +D + E +++ I KL + L+K+
Sbjct: 2930 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES---------LIKD 2980
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEK----EKEQLQKKLQEALTSRKAILKKAQEKER 1199
S T S ++ + E L K EK LQ +L T+ K+ +E+E
Sbjct: 2981 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 3040
Query: 1200 HLREEL------KQQKDDY--------NRLQE-QFDEQSKENENIGDQLRQLQ------- 1237
L+E L K+Q + N L+E +F E EN +L+ LQ
Sbjct: 3041 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 3100
Query: 1238 --IQVRESIDGKLPST---DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPS-- 1290
+++ + L S D++ L + + TEQ H++ N+ +
Sbjct: 3101 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3160
Query: 1291 -------------------HSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV------ 1325
H S + ++ Q K ++A K +++L
Sbjct: 3161 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3220
Query: 1326 ------SSTTSELTKKSEEVFQ----LQEQINK---------QGL--------------- 1351
S TS++ + E + Q L +Q+++ QG+
Sbjct: 3221 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3280
Query: 1352 ----EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
E++S+ V +AE +LQ++ E+ + + LE L ++ K++ EE
Sbjct: 3281 EFDDELDSMAPVGRDAE----TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3336
Query: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE---RIKQLQVELCEM 1464
L G + EA L+K +++ D +A Q+E K +E ++K+ + L +
Sbjct: 3337 SPDLVGIKRDLEA-LSKQCNKLL---DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3392
Query: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS-LARGTIERLTKS---- 1519
++ E G + I ++L + +KE ++ + Q++++ L +G I+ KS
Sbjct: 3393 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3452
Query: 1520 -----LADVESQVSAQNKEKDTVLGRLALLQE--------------------ERDKLITE 1554
L DV ++ NK+ V R A LQE + ++L+
Sbjct: 3453 GLEHDLDDVNARWKTLNKK---VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3509
Query: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
E + + + + KL L+ L +D++ V+ I+ + KIA + E +K K L K+
Sbjct: 3510 QKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKR-EGEKIATTAEPADKVKIL-KQ 3566
Query: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR-------------------STEA 1655
+L +E + N+AE +E + Q+ + L T+A
Sbjct: 3567 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3626
Query: 1656 NKKETEKQLQEAEQE--MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC 1713
+K E + +A ++ + K + + + K+L E+ D +++++ + E
Sbjct: 3627 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3686
Query: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQAN 1772
E S + +++ L K+ E + L D LS+ VQD + EG +Q+
Sbjct: 3687 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGLWKQQSE 3744
Query: 1773 LEATE-----KHDNQTNVTEEGTQSIPGETEEQ--------DSLSMSTRPTCSESVPSAK 1819
L + + N G + + T ++ +++ + S AK
Sbjct: 3745 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804
Query: 1820 SANPAVS---KDFSSHDEINNYLQQID-----------------QLKERIAGLEEEKQKN 1859
+ A+ + S+H+E+ +L +++ Q + R L++E + N
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3864
Query: 1860 KEFSQTLENEKNTLLSQIS--TKDGELKMLQEEVTKMNLLNQQIQEELSRVTK--LKETA 1915
K +L + LL + ++G KM+ E+ + L++ I +++ + L+
Sbjct: 3865 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3924
Query: 1916 EEEKDDLEERLMNQLAELNGSIGNYC--QDVTDAQIK-NELLESEMKNLKKCVSELEEEK 1972
++ D E + + + S+G+ QD T AQ++ + E+ K + +L +
Sbjct: 3925 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3984
Query: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ 2032
+++ ++ E + K+ L+K+ K + + + QL+ R Q
Sbjct: 3985 HKIMTACSEEEKQSMKKKLDKV------------LKNYDTICQINSERYLQLE----RAQ 4028
Query: 2033 EKISALERTVKALEFVQTESQKDLE------ITKENLAQAVEHRKKAQAELASFKVLLDD 2086
++ T + L TE+Q + + E L Q E ++ + +A K +D
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 4088
Query: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLD 2146
++L + +Q + + Q ED+++R +E + + +K+D
Sbjct: 4089 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEA-ISQSTQFHDKID 4147
Query: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206
+ + E + + + +K +Q+ EN + +V
Sbjct: 4148 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSV---------------------- 4185
Query: 2207 EAKKWERKFSDAIQSKEEEIRL-----KEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
+ +K + + Q EE I K+ + ++D+L QM E NI L ++
Sbjct: 4186 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE----NIHTLVEER 4241
Query: 2262 QIWESKAQTEVQLQQKV-CDTLQ-----GENKELLSQLEETR---HLYHSSQNELAKLES 2312
E+K ++L +K CD + + ++ + LE+ + Q +
Sbjct: 4242 ---EAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4298
Query: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS---------KFSYEQLETDL 2363
E+ L+++L + N + G + I ++ D NS K ++LE +
Sbjct: 4299 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4358
Query: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE 2423
QA+ + L + + ++G + A I + ++I+EL+ S+ ++
Sbjct: 4359 QAAVQYQDGLQAVFDWVD------IAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQ 4412
Query: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
I +E N +A +L+ LK + +E+ + Q D ++ + +RI+ +L
Sbjct: 4413 QIEMERLNHQA-----ELL--LKKVTEESDKHTVQ-DPLMELKLIWDSLEERIINRQHKL 4464
Query: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
E L++ Q A E GL S + + ++ EL ++ N V
Sbjct: 4465 EGALLAL-----GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 2544 ITIKDSQQ------KQLLEVQL-QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
+ + + + L+E ++ L+NK L ++ + E E ++ + +
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4579
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTL-GLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
+ EIE L+ ++ R + A + G L QL V E A + + +
Sbjct: 4580 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4639
Query: 2656 AELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD---- 2711
+ ++ L K A + + + LK++ + + NE +T E LA +
Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVE----TKLNERKTKLEEALNLAMEFHNS 4695
Query: 2712 -------LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
L + EQ L + ++ + L + H E++ EL K
Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH-REQIIELD-KTGTH 4753
Query: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
LK +Q ++ L+ ++ L+S S EK+ Q+L+ + L
Sbjct: 4754 LKYFSQKQDVVLI---KNLLISVQ------------SRWEKVVQRLVER-------GRSL 4791
Query: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
+D+ + + F +A + L W LE+ KS + + A P ++ K+
Sbjct: 4792 DDARKRAKQFHEAWSKLME-----W--LEESEKSLDSELEIANDPDKIKTQLAQHKEFQK 4844
Query: 2885 SL---------QNDRDRLLKELKNLQQQYLQINQEITEL 2914
SL N R LKE +L L+++ ++EL
Sbjct: 4845 SLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4883
Score = 156 bits (395), Expect = 3e-37
Identities = 482/2513 (19%), Positives = 1005/2513 (39%), Gaps = 376/2513 (14%)
Query: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA---QLTQAQAEQ--PA 176
L + S +S H + ++ +K+K ++Q++++ I QA L+ E+ A
Sbjct: 2847 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA 2906
Query: 177 QSSTEMEEFVMMKQQLQEK-EEFISTLQ-AQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
+ S ++E + + +++K E + LQ A S Q +Q ++ D + E Q + H
Sbjct: 2907 ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP 2966
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
+ KL VL+ +++H++ + E T AE N +L
Sbjct: 2967 ---------------ISAKLDVLESLIKDHKD--FSKTLTAQSHMYEKTIAEGENLLLKT 3009
Query: 295 QLQQ---MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQ 351
Q + ++ + NT++ +T ++ K K++ E E+ L + E + +++ +
Sbjct: 3010 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLK-ESLEKALKYKEQVETLWPWIDKCQN 3068
Query: 352 AGQA------QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405
+ AE E+ + L+ K EM++ + L T L S C+ K+ +
Sbjct: 3069 NLEEIKFCLDPAEGENSIAKLKSLQK-EMDQHFGMVELLNNTANSLLSVCEIDKE----V 3123
Query: 406 LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465
+ D+N+ +Q + + +QL K + + + Q V
Sbjct: 3124 VTDENKSLIQK---VDMVTEQLHSKKFCLENMTQKF------------------KEFQEV 3162
Query: 466 TEENIASLQ--KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
++E+ LQ K +++ + G+ S+ L L+ + + L +A + +
Sbjct: 3163 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-------QALKHQVDLAKR 3215
Query: 524 VSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581
+++ +V+ ++ + +S DVL T +Q+H LS ++ E+ +FL+ +LQ
Sbjct: 3216 LAQDLVVEASDSKGTS------DVLLQVETIAQEHSTLS------QQVDEKCSFLETKLQ 3263
Query: 582 G-KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE-- 638
G + E+ Q E + +AP+ G+D + ++ ++ A K+
Sbjct: 3264 GIGHFQNTIREMFSQFAEFDDELDSMAPV---------GRDAETLQKQKETIKAFLKKLE 3314
Query: 639 --QASTEHQSRTSEE-ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
AS ++ ++T + ++ + +L K+D L A+ QC++ L+R +++ +
Sbjct: 3315 ALMASNDNANKTCKMMLATEETSPDLVGIKRD----LEALSK--QCNK-LLDRAQAREEQ 3367
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755
+E + +E Y K KE S L Q EE +++ +E +Q L+ K
Sbjct: 3368 VEGTIKRLEEFYSK-----LKEFSILLQKAEEHEES----QGPVGMETETINQQLNMFKV 3418
Query: 756 LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815
Q KQ ++N Q + +++ L + ++ K+ + K+
Sbjct: 3419 FQKEEIEPLQGKQQDVNWLG---QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3475
Query: 816 QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG---AERVRHISSKVEELSQALSQKE 872
+L + L + SL S + + E V + + + ++++E Q L Q+
Sbjct: 3476 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE--QKLLQRL 3533
Query: 873 LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932
L+ K ++ KR+ E + T E D+ + +++ L+ +L + +T
Sbjct: 3534 LDDRKSTVEVI--KREGEKIATTAEPADK------VKILKQLSLLDSRWEALLNKAETRN 3585
Query: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG-QISKEELQHEFDLLKKENEQR 991
QL +S + E +E NE + +++ P G Q SK E E +
Sbjct: 3586 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE----------EQIAQ 3635
Query: 992 KRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV---EEDKENKEYSE 1048
+ L+ +IN + L + + + L L K++ S+ + +V E +++ SE
Sbjct: 3636 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3695
Query: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA----EEQFQALVKQMNQTLQDK 1104
+ C + E EVEL + ++ +KL+ + + L KQ ++ +
Sbjct: 3696 LLQQALCNA------KIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL---R 3746
Query: 1105 TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP----CTGSSEHWKP 1160
Q D+L + + +QA++ L + GD V ++++ + T S
Sbjct: 3747 VLQEDILLRKQNVDQALLNGL--ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804
Query: 1161 ELEEKILA---LEKEKEQL----QKKLQEALTSRKAILKKAQEKERHLR-EELKQQKDDY 1212
LE+ + L E+L K E L+ +LK + + +R +ELK++ +
Sbjct: 3805 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3864
Query: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE----SCSSTPGLEEPLF 1268
L + +E S L + + RE ++ K+ + D + S + T +EE
Sbjct: 3865 KALLDSLNEVSSA------LLELVPWRAREGLE-KMVAEDNERYRLVSDTITQKVEEIDA 3917
Query: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ--IKAQLKEIEAEKVELELKVS 1326
++ L W + +E G + Q AQL+ + +E+ L+
Sbjct: 3918 AILRSQQFDQAADAEL--SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI-LRHK 3974
Query: 1327 STTSELTKKSEEVFQLQEQINKQGLEIES---LKTVSHEAEVHAESLQQKLESSQLQIAG 1383
+L K ++ + KQ ++ + LK ++++E Q + L
Sbjct: 3975 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQF 4034
Query: 1384 LEHLRELQPKLDELQKLISK-------------KEEDVSYLSGQLSEKEAALTK------ 1424
E EL P L E Q +IS+ ++E+ L ++E + + K
Sbjct: 4035 WETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 4094
Query: 1425 ------------IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ---LQVELCEMKQKPE 1469
IQ + + + L + ++ +A DE I Q ++ ++ + E
Sbjct: 4095 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4154
Query: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
I E R I +++ KE + ENK++ ++ + E L + ++ ++
Sbjct: 4155 RIVERLRQPPSISAEVEKI----KEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4210
Query: 1530 QNKEKDTV-----LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
+K+ L ++ + E L+ E + LL+ L+ ++L +D +
Sbjct: 4211 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4270
Query: 1585 KLVKEIES--LKSSKIAESTEWQEKHKE----LQKEYEILLQ-SYENVSNEAERIQHVVE 1637
++++E + S + + E E +E LQ+E +I++ E ++ E + +V+
Sbjct: 4271 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4330
Query: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
E + L K+ +L+EA Q + ++ + Q + + +
Sbjct: 4331 KSIDELNSAWDSLNKAW---KDRIDKLEEAMQAAVQYQDGL--------QAVFDWVDIAG 4379
Query: 1698 RLRAEVHPAG---DTAKECMETL--LSSNASMKE-ELERVKMEYETLSKKFQS------- 1744
A + P G +T K+ +E L S A ++ E+ER+ + E L KK
Sbjct: 4380 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4439
Query: 1745 ---LMSEK---DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPG 1795
LM K DSL E + + +H++EG + + EG Q G
Sbjct: 4440 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4499
Query: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSK------DFSSHDEINNYLQQIDQLKERI 1849
+ + ++ V + +S AV+K + S+ +E +N +++ L +R
Sbjct: 4500 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4559
Query: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK----------MNLLNQ 1899
+ E+ ++ K+ + + L Q GE++ LQ+ +T + L +
Sbjct: 4560 QNVLEKTEQRKQ-------QLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4612
Query: 1900 QIQEELS---RVTKLKETAEEEKDDLEERLMNQLAELNGSIG-NYCQDVTDAQIKNELLE 1955
+E+L+ V E EE L ++ LA S N QD+ + + K E +E
Sbjct: 4613 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4672
Query: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+++ K ++LEE ++ ++ +++ + A++ S + + +
Sbjct: 4673 TKLNERK---TKLEEALNLAMEFHNSLQ-----DFINWLTQAEQTLNVASRPSLILDTVL 4724
Query: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR-KKAQ 2074
+ E K + ++E+I L++T L++ SQK + +NL +V+ R +K
Sbjct: 4725 FQIDEHKVFANEVNSHREQIIELDKTGTHLKYF---SQKQDVVLIKNLLISVQSRWEKVV 4781
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
L LDD + A + KL + L+ +++S+ S+++ ++ + + + A+ K
Sbjct: 4782 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4841
Query: 2135 LKEKKNMQEKL-DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
++ + + D R L+E L K D + +L++ D+ +
Sbjct: 4842 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSV----- 4895
Query: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEE-----EIRLKE---------------DNC 2233
+R ++EA + +F+DA+Q+ + E +L E DN
Sbjct: 4896 ------ERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4949
Query: 2234 SVLKDQLRQMSIHMEELKINISRL---EHDKQIWESKAQTEVQLQ-QKVCD---TLQGEN 2286
+ +L + + ++ LK + L D W E+ + + VC + Q
Sbjct: 4950 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 5009
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
+ L Q EE + H+ LA+ E L+ L D ++L +Q + ++
Sbjct: 5010 EAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKR 5068
Query: 2347 ADIQNS--------KFSYEQLETDLQASRELTSRLHEEI----NMKEQKIISLLSG---K 2391
A++ + + T ++ + EE+ +Q++ S L+G K
Sbjct: 5069 AELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAK 5128
Query: 2392 EEAIQVAIAELR------QQHDKEI--KELENLLSQEEEENIVLEEENKKAVD 2436
+E ++ +A L+ DKE+ +E+E + + E +EE +K D
Sbjct: 5129 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD 5181
Score = 129 bits (324), Expect = 5e-29
Identities = 476/2605 (18%), Positives = 1047/2605 (40%), Gaps = 386/2605 (14%)
Query: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQE------RLAYAEQLVVELKDIIRQK--D 72
D D + + L H ++ + T Q+ QE ++ A+ L +L +++++
Sbjct: 2846 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2905
Query: 73 VQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132
+L ++ E + + K + K + H ++ S +++ ++M L T+ EEQ
Sbjct: 2906 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF-QQMSRDFQAWLDTK--KEEQN 2962
Query: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192
H S+ +++ ++ +++ ++ TL AQ M ++ +
Sbjct: 2963 KSHPISA-----KLDVLESLIKDHKDFSKTLTAQSH------------------MYEKTI 2999
Query: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252
E E + L+ Q S+ A Q ++ F QV+ E++L + + +A + ++
Sbjct: 3000 AEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA---LKYKE 3054
Query: 253 KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN--QILSQQLQQMEAEHNTLRNTV 310
++ L +++ + +L +D + E + A+ ++ + + Q +E +NT + +
Sbjct: 3055 QVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 3114
Query: 311 -------ETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG-QAQAELESR 362
E +E+K L++K+++ V E+ S E M ++F++ +++ +L+
Sbjct: 3115 SVCEIDKEVVTDENKSLIQKVDM-VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 3173
Query: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS------ 416
L+ + ++ L++ +T Q+ A D +L QD +A S
Sbjct: 3174 KEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV 3233
Query: 417 ---AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE-ENIAS 472
+TI Q L Q+ E FL Q Q + +++++ + E +++A
Sbjct: 3234 LLQVETIAQEHSTLSQQVDEKCSFLETK--LQGIGHFQNTIREMFSQFAEFDDELDSMAP 3291
Query: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE----ADREVSEIS 528
+ + L+ +K + +LE L A N+ + ++ A T R++ +S
Sbjct: 3292 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3351
Query: 529 -----IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
++D A R E + + + E F K KE S+LL + +E +E + ++ +
Sbjct: 3352 KQCNKLLDRAQAREEQVEGTIKRLEE--FYSKLKEFSILLQKAEEHEESQGPVGMETETI 3409
Query: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
+ +V ++E++ ++G+ + + GQ + +S +E +
Sbjct: 3410 NQQLNMFKVFQKEEIEPLQGK-------QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVN 3462
Query: 644 HQSRTSEE------ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD------ELERLKS 691
+ +T + L +A + + + LS + D + + E + +K+
Sbjct: 3463 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA 3522
Query: 692 QILELEL------NFHKAQEIYEKNLDEKA------------KEISNLNQLIEEFKKNAD 733
QI E +L + E+ ++ ++ A K++S L+ E A+
Sbjct: 3523 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3582
Query: 734 NNSSAFTALSEERDQLLSQVKELS-MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
+ +S Q ++ L+ +T + ++ E +A + + + D+
Sbjct: 3583 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3642
Query: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
++ H + + +K+ + + D VQ + +Q + ++ SE+L+ A
Sbjct: 3643 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR-SELLQQAL 3701
Query: 853 RVRHISSKVE-ELSQALSQKELEITKMD------QLLLEKKRDVETLQQTIEEKDQQVTE 905
I + E EL L++ +++K+ + L +++ ++ LQ+ I + Q V +
Sbjct: 3702 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3761
Query: 906 ISFSMTEKMVQLN-EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
+ E + Q +E + +++ +K + +++ + +E+ +++ L ++
Sbjct: 3762 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3821
Query: 965 EMSP-AGQISKEELQHEFDLLKKEN----EQRKRKLQAALINRKELLQRVSRLEEELANL 1019
E+ ++ E L +E +LK E + R ++L+ N K LL ++ + L L
Sbjct: 3822 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3881
Query: 1020 KDESKKEIPLSETERGE--VEEDKENKEYSEKCVTSKCQEIEIYL---KQTISEKEVELQ 1074
+P E E V ED E +T K +EI+ + +Q + EL
Sbjct: 3882 -------VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS 3934
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQ-DKTNQIDLLQAEISENQAIIQKLITSN---- 1129
I + E+KL + + Q + LQ KT +++L+ ++ II L+ S
Sbjct: 3935 WIT-ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR-----HKDIIDDLVKSGHKIM 3988
Query: 1130 TDASDGDSVALVKETVVI----SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
T S+ + ++ K+ + C +SE + E+ +L + + ++L LT
Sbjct: 3989 TACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL--ERAQSLVNQFWETYEELWPWLT 4046
Query: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI---GDQLRQLQIQVRE 1242
++I+ + E L+QQ++++ +L+E E + + G QL +L
Sbjct: 4047 ETQSIISQLPAPALEY-ETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 4105
Query: 1243 SIDGKLPSTD------QQESCSSTPGLEEPLFKATEQHHT-QPVLESNLCPDWPSHSEDA 1295
SI K + D +++ L+E + ++T+ H +LES
Sbjct: 4106 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES------------- 4152
Query: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ---EQINKQGLE 1352
+ +I +L++ + E+E K+ SE S ++ +LQ E + ++G E
Sbjct: 4153 --------LERIVERLRQPPSISAEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4203
Query: 1353 IESLKTVSHEAEVHAESLQQKLESS-----------QLQIAGLEHLRELQPKL--DELQK 1399
+ + ++ + ++ A+++Q KL+ + + A L + EL K D +
Sbjct: 4204 MIA-RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4262
Query: 1400 LISKKE--------EDVSYLSGQLSEKEAALTKIQTEII---EQEDLIKALHTQLEMQAK 1448
+++ K+ ED + +++ A I+ EI E+ D++ L ++L
Sbjct: 4263 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG 4322
Query: 1449 EHDERIKQLQVELCEM---------KQKPEEIGEESRAKQQIQRKLQAA----------- 1488
E D+ I + ++ K + +++ E +A Q Q LQA
Sbjct: 4323 EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4382
Query: 1489 ---------LISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV-- 1537
L + K+ ++E K + E + +ERL A++ + + +K TV
Sbjct: 4383 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEESDKHTVQD 4441
Query: 1538 -LGRLALLQEERDKLIT----EMDRSLLENQSLSSSCESLKLAL---EGLTEDKEKL--- 1586
L L L+ + ++ I +++ +LL + + L L EGL +++ +
Sbjct: 4442 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4501
Query: 1587 --VKEIESLK---------------------SSKIAESTEWQEKHKELQKEYEILLQSYE 1623
EIE K + + ES+ +E LQ + E+L Q ++
Sbjct: 4502 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA-SNLQNKLEVLNQRWQ 4560
Query: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
NV + E+ + ++ ++ + +G++ + +TE+ L A + + + E ++
Sbjct: 4561 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL-ASKPLGGLPETAKEQLN 4619
Query: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
+ E + + ++ + C + S+ ++ +++ +K ++E++ K
Sbjct: 4620 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPK---SAETNIDQDINNLKEKWESVETK-- 4674
Query: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQAN-LEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
++E+ + EE +L + ++ N L E+ N + ++ + +E
Sbjct: 4675 --LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4732
Query: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI-----------NNYLQQIDQLKERIAG 1851
+ + + K+ K FS ++ + + + + +L ER
Sbjct: 4733 FANEVNSHREQIIELDKTGTHL--KYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4790
Query: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ--EEVTKMNLLNQQIQEELSRVT 1909
L++ +++ K+F + L + D EL++ +++ +++ Q+ L
Sbjct: 4791 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4850
Query: 1910 KLKETAEEEKDDLEE---------RLMNQLAELNGSIGNYCQDVTDAQIKNE---LLESE 1957
+ +T L+E +L + L+EL C + Q K E L +
Sbjct: 4851 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4910
Query: 1958 MKN-LKKCVSELEEEKQQLVKEK-TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+ L+ + L + QL +++ + ++ ++ + QKE G ++ + + LK
Sbjct: 4911 FTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS---VQALK 4967
Query: 2016 EKQQEVKQLQKDCIRY----QEKISALERTVKALEF-VQTESQKDLEITKE--NLAQA-V 2067
+E+ + +D + +++S TV AL QT + L +E ++ A +
Sbjct: 4968 RSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL 5027
Query: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLK-LKKELQSNKESVKSQMKQKDEDL--- 2123
E +A+ L VL DD +A R L D K K+L+ + + D L
Sbjct: 5028 EWLAEAEQTLRFHGVLPDD--EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAIC 5085
Query: 2124 ---------------ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ---VT 2165
R E+ + ++ + L L ++ LE + +Q T
Sbjct: 5086 HPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETT 5145
Query: 2166 LNKKDKEV-QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSD--AIQS- 2221
L KDKEV Q E + + + + F + M+ Q D D+V K ++R+ +D ++QS
Sbjct: 5146 LTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV---TKTYKRRAADPSSLQSH 5202
Query: 2222 ----KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK 2277
+ K S L Q I + ++N+ + +Q+W + +L
Sbjct: 5203 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL-LVSKWQQVWLLALERRRKL--- 5258
Query: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE-LKSLKDQLTDLSNSLEKCKEQKG 2336
+ L +LEE R + + K + K ++ D ++K ++ K
Sbjct: 5259 ---------NDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGK- 5308
Query: 2337 NLEGIIRQQEAD-IQNSKFSYEQLE 2360
I RQ+ D I +SKF +LE
Sbjct: 5309 ----ITRQEFIDGILSSKFPTSRLE 5329
Score = 68.9 bits (167), Expect = 8e-11
Identities = 263/1488 (17%), Positives = 567/1488 (38%), Gaps = 262/1488 (17%)
Query: 1900 QIQEELSRVTKLKETAEEEKDDLE--ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
QI++ L + + L + EE+ +++ + L+N + E+ + D T+ +ES
Sbjct: 761 QIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL-----DRTEWGSDLPSVESH 815
Query: 1958 M---KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
+ KN+ + + E E ++ + ++ + ++ Y EK+ + S +L
Sbjct: 816 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE------SQYAKLLNTS 869
Query: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
+ +++ + L R ++ L E + E D N+A+ ++ +
Sbjct: 870 RNQERHLDTLHNFVSRATNELIWLN------EKEEEEVAYDWSERNTNIARKKDYHAELM 923
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
EL + + Q A ++L +N + +++ + ++++Q +L Q E+H
Sbjct: 924 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQW-----SWILQLCQCVEQH 978
Query: 2135 LKEK-------KNMQEKLDALRREKVHLEETIG-EIQVTLNKKDKEVQQLQENLD----- 2181
+KE + +E D LR K ++ + +++K + VQ+ E +
Sbjct: 979 IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY 1038
Query: 2182 -STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL-KEDNCSVLKDQ 2239
ST+ L K++ L + R D K ++ EI + K+D C + +
Sbjct: 1039 KSTIANLMGKAKTIIQL---KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 1095
Query: 2240 LR------------------------------QMSIHMEELKINISRLEHDKQI------ 2263
R ++ +E+ N+ L H+ I
Sbjct: 1096 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVV 1155
Query: 2264 -WESKAQTEVQLQ----QKVCDTLQGENKELLSQ--------LEETRHLYHSSQNELAKL 2310
W +++ + L GE++++LS LE+++ S +++ +L
Sbjct: 1156 SWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 1215
Query: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE--------QLETD 2362
E E+ K +L S E+ +++ E + ++++N + E Q+ T
Sbjct: 1216 EKEVNVCKQYYQELLKSAEREEQE----ESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1271
Query: 2363 LQAS--RELTSRLHEEINMKEQ-----KIISLLSGK------EEAIQVAIAELRQQHDKE 2409
L+ E R+ E+ +K++ + ++ K + A ++ LR + +
Sbjct: 1272 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1331
Query: 2410 IKELENLLSQ-----EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
++ + + S ++ + + L +N +A + +L ET ++ I K +++ +
Sbjct: 1332 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 1391
Query: 2465 SMSSLQNDRD----------------RIVGD--YQQLEERHLSIILEK---DQLI---QE 2500
++ +++ D + + D ++ +ER L K DQL+ Q
Sbjct: 1392 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 1451
Query: 2501 AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560
+ + ++ G+ + LD + IQ E + I + + L QL
Sbjct: 1452 VHVQIDNRLRDLEGIGKSLKYYRDTYHPLD-DWIQQVETTQRKIQENQPENSKTLATQLN 1510
Query: 2561 QNK----ELENKYAKLEEKLKESEEANEDLR------RSFNALQEEKQDLSKEIESLKVS 2610
Q K E+E K +K++E K +E+ + ++ ++ A+ + +Q + ++ S
Sbjct: 1511 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1570
Query: 2611 ISQLTRQVTALQEEGT--LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
+ ++ L+ T + L +K + + RL +K + E ++E V KE
Sbjct: 1571 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL----EEEEKSLEEEKKEHVEKAKE 1626
Query: 2669 AAKKVGEIEDKLK---KELKHLHHDAGIMRNETETAEERVAELAR--DLVEMEQKLLMVT 2723
K V I LK K K I E T +E+++E + L + M
Sbjct: 1627 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1686
Query: 2724 KENKGLTAQIQS--------FGRSMSSLQNSRDHANEELD-----ELKRKYDASLKELAQ 2770
+E L Q+++ F S+ LQ S+ + +++ E +++Y L+ +
Sbjct: 1687 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1746
Query: 2771 L---KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
L E L+ + ++ + + + + + + E + + + L+++
Sbjct: 1747 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1806
Query: 2828 YNQVQSFSKAM-------ASLQNERDHLWNELEKFR---------KSEEGKQRSAAQPST 2871
++ KA+ A ++ E+ +L E K K E K + Q
Sbjct: 1807 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1866
Query: 2872 SPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE------ITELHPLKAQLQEYQ 2925
S ++++L +S++ D +R + K + +Q QE I E + L E
Sbjct: 1867 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-T 1925
Query: 2926 DKTKAFQIMQEELRQ--ENLSWQHE----LHQLRM--------------------EKSSW 2959
D QE L Q + + QHE HQ + EK
Sbjct: 1926 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1985
Query: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASP 3017
+ + + +K Y A+++ ++++ +L EL + + +Q Q A
Sbjct: 1986 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 2045
Query: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQ---LCDTSQ 3074
D L+ + + ++ D + H+ +LR ++ N ++LE + S + DTS
Sbjct: 2046 DDINGLMTKLKRQKSFSEDVIS--HKGDLRYITISGN--RVLEAAKSCSKRDGGKVDTSA 2101
Query: 3075 SLRENQQ-------HYGDLLNHCAVLEKQVQEL----------QAGPL-NIDVAPGAPQE 3116
+ RE Q+ + L + C VL +++L G L + +
Sbjct: 2102 THREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK 2161
Query: 3117 KNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR 3164
DP+ L+ + Q Q+ + + V +L+K E D R
Sbjct: 2162 HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDAR 2209
Score = 33.9 bits (76), Expect = 2.7
Identities = 56/307 (18%), Positives = 134/307 (43%), Gaps = 24/307 (7%)
Query: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
N+ +L+Q R+ L + + + ++ E+ ++ ++L N +++ +L +E ++
Sbjct: 752 NSLQTLKLMQIRKPLLKSSLLDQNLTEE--EINMKFVQDLLNWVDEMQVQLDRTEWGSD- 808
Query: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
S + E +++ + IE + S+ + +++ +Q L L +A E++HRL
Sbjct: 809 -LPSVESHLENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYA------EKLHRLE 859
Query: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV 2705
+ ++ E L + ++ E+ +KE + + +D ++
Sbjct: 860 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 919
Query: 2706 AELARDLVEMEQKLLMVTK-------ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
AEL R+L + E+ + V + EN I+++ +M + + + +++
Sbjct: 920 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 979
Query: 2759 RKYDASLKELAQLKE-QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQL 2817
++ A + KE L +DA+ + + +S S+ LE L Q+ + + E+L
Sbjct: 980 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS----SIHKLEDLVQESMEEKEEL 1035
Query: 2818 LHLSSQL 2824
L S +
Sbjct: 1036 LQYKSTI 1042
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 218 bits (554), Expect = 1e-55
Identities = 647/3338 (19%), Positives = 1330/3338 (39%), Gaps = 486/3338 (14%)
Query: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS 133
+L++++++L+EE+K K K+L+ +++++K +++ + G + S E++S
Sbjct: 1427 RLEEEEKSLEEEKKEHVEKAKELQKW----VSNISKTLKDAEKAGKPPFSKQKISSEEIS 1482
Query: 134 ------------------KH-DKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
KH DK + EE E+EK LQE L+ L Q Q Q
Sbjct: 1483 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL--FSESLKQLQESQ 1540
Query: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA-QQVVREKDARFETQVRLH 233
+ ++EE ++ ++Q QE +E + + L+QT+ Q+ D E +
Sbjct: 1541 TS-GDVKVEEKIVAERQ-QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1598
Query: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
+ E LQ Q + + + ++ + L+E+ E L + L++Q+L A+ + + L+
Sbjct: 1599 KQEELQKDMQGSAQA-LAEVVKNTENFLKENGEKLSQEDKA--LIEQKLNEAKIKCEQLN 1655
Query: 294 QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
+ +Q + E + + T E E ++++E E K NL + + ++ + E+AG
Sbjct: 1656 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLE----ESKTKIENLLDWLSNVDKDSERAG 1711
Query: 354 QAQAELESRYSALEQKHKA-----EMEEKTSHILSLQKTGQ------ELQSACDALKDQN 402
++ + Q+ E +E ++L GQ L +K Q+
Sbjct: 1712 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1771
Query: 403 SKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFL--NRLPLQQH-ETASQTSFPDV 457
K++ A QSAQ + LE Q Q S E + L N L+ H ETA S
Sbjct: 1772 EKIISQHQAVIIATQSAQVL--LEKQGQYLSPEEKEKLQKNMKELKVHYETALAES---- 1825
Query: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
E +T L+K + + L S ELE L+A + ++ +T L+ Q
Sbjct: 1826 --EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1883
Query: 518 GE-ADREVSEISIVDIANKR------SSSAEESGQ--------------DVLENTFSQKH 556
E ++ + I+ R S S + G+ D + F +
Sbjct: 1884 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1943
Query: 557 KELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLE 616
+ +VL +K+ ++ + G A E K + E + P ++ LE
Sbjct: 1944 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPIAVDPKNLQRQLE 2001
Query: 617 DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676
+T ++ + +Q + E +T+E L DA L K D K+L
Sbjct: 2002 ET----------KALQGQISSQQVAVEKLKKTAEV--LLDARGSLLPAKNDIQKTLD--- 2046
Query: 677 DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE--------- 727
DI ++D + + + +L++ ++ + + LDE + N+ ++E
Sbjct: 2047 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQD-GLDEMLDWMGNVESSLKEQGQVPLNST 2105
Query: 728 -----------FKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776
+++ S+ A++E+ + + + + S + L+A++K L +EA
Sbjct: 2106 ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM-ETTDPSTASSLQAKMKDLSARFSEA 2164
Query: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
+ + E+ + L T+ + ++ +E L +V + + + L
Sbjct: 2165 SHKHK---ETLAKMEELKTK-VELFENLSEKLQTFLETKTQALTEVDVPGKD----VTEL 2216
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQ--ALSQKELEITKMDQLLLEKKRDVETLQQ 894
+Q SE LE + + + S ++E+S S K L + K + L + + ++
Sbjct: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL----SKKFKEMED 2272
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
TI+EK + VT E+ + V +K+LK + E KK + + +
Sbjct: 2273 TIKEKKEAVTSCQ-----------EQLDAFQVLVKSLKSWIK-----ETTKKVPIVQPSF 2316
Query: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
+ L ++ ++ ++LQ ++ L E + K+ + I+ L+ V+ +
Sbjct: 2317 GAEDLGKSLEDT--------KKLQEKWSLKTPEIQ----KVNNSGISLCNLISAVTTPAK 2364
Query: 1015 ELANLKDES---KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
+A +K E + TE + + + ++ +++ + LK I+E
Sbjct: 2365 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT 2424
Query: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMN-----------QTLQDKTNQIDLLQAEISENQA 1120
+L ++K EE A + Q + K + ++ + Q +AE+ +N
Sbjct: 2425 KLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2484
Query: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
+Q+L T+ L++E P T + WK L E I + +E QL
Sbjct: 2485 KVQELKDKLTE--------LLEEN-----PDTPEAPRWKQMLTE-IDSKWQELNQLTIDR 2530
Query: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240
Q+ L L + Q E L++ L +++ + S + + Q +Q+QI +
Sbjct: 2531 QQKLEESSNNLTQFQTVEAQLKQWLVEKE----LMVSVLGPLSIDPNMLNTQRQQVQILL 2586
Query: 1241 RESIDGKLPSTDQQESCS----STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
+E K P +Q + S PG E+P + + V + W S + S
Sbjct: 2587 QEFATRK-PQYEQLTAAGQGILSRPG-EDPSLRGIVKEQLAAVTQK-----WDSLTGQLS 2639
Query: 1297 AL-----QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Q Q ++ L+ + + +L+ K+SS+ + T QL E K
Sbjct: 2640 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL-ETAQKMKQ 2698
Query: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
EI+ K A+ E L ++ L+ E R+L+ L + + K E V +L
Sbjct: 2699 EIQQEKKQIKVAQALCEDLSALVKEEYLKA---ELSRQLEGILKSFKDVEQKAENHVQHL 2755
Query: 1412 SG---------QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462
Q+S A + E + I A LE K+H + K L +
Sbjct: 2756 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-S 2814
Query: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN-----KSLQEELSLARGTIERLT 1517
M +K GE K Q K AAL + +K N K ++E + + ++E+
Sbjct: 2815 HMYEKTIAEGENLLLKTQGSEK--AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2872
Query: 1518 KSLADVESQV----SAQNK-----------EKDTVLGRLALLQEERDKLITEMDRSLLEN 1562
K VE+ QN E + + +L LQ+E D+ ++ LL N
Sbjct: 2873 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE--LLNN 2930
Query: 1563 --QSLSSSCESLKLALEGLTEDKEKLVKEI----ESLKSSKIA------ESTEWQEKHKE 1610
SL S CE K E +T++ + L++++ E L S K + E+QE KE
Sbjct: 2931 TANSLLSVCEIDK---EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2987
Query: 1611 LQKEYEIL---LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
+++ + L ++++ ++A +++ Q+K S +A K + + + A
Sbjct: 2988 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK--------SLQALKHQVDLAKRLA 3039
Query: 1668 EQEMEEMKEKMRKFAKSKQQKILELE---EENDRLRAEVHPAGDTAKECMETLLSSNASM 1724
+ + E + +K +L++E +E+ L +V D +ET L
Sbjct: 3040 QDLVVEASD-----SKGTSDVLLQVETIAQEHSTLSQQV----DEKCSFLETKLQGIGHF 3090
Query: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
+ + + ++ + S M+ +E +Q K I+ + K L A+ + N+T
Sbjct: 3091 QNTIREMFSQFAEFDDELDS-MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTC 3149
Query: 1785 ----VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
TEE + + G + ++LS C++ + A++ V +E + L+
Sbjct: 3150 KMMLATEETSPDLVGIKRDLEALSKQ----CNKLLDRAQAREEQVEGTIKRLEEFYSKLK 3205
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
+ L ++ EE + ++T+ + N + ++ K+ E++ LQ + +N L Q
Sbjct: 3206 EFSILLQKAEEHEESQGPVGMETETINQQLN--MFKVFQKE-EIEPLQGKQQDVNWLGQG 3262
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
+ + ++ T + E + DD+ R LN + + +A + + +++
Sbjct: 3263 LIQSAAKSTST-QGLEHDLDDVNARWKT----LNKKVAQRAAQLQEALLHCGRFQDALES 3317
Query: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
L + + EE LV + +E K+ AQ + K LQ LL +++
Sbjct: 3318 LLSWMVDTEE----LVANQKPPSAEF------KVVKAQIQ-----EQKLLQRLLDDRKST 3362
Query: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
V+ ++++ EKI+ ++ ++ S L+ E L E R + +L
Sbjct: 3363 VEVIKRE----GEKIATTAEPADKVKILKQLSL--LDSRWEALLNKAETRNR---QLEGI 3413
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEE-----KHL 2135
V+ E L + L ++ N E + +Q + +E + + ++ KHL
Sbjct: 3414 SVVAQQFH-ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3472
Query: 2136 KEKKNMQEKLDAL--RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
+ ++ + L L R +K ++ + QV + ++ E L + F +
Sbjct: 3473 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
Query: 2194 MSSLQDDRDRVIDEAKKWERK--FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
L + + V D+ K + ++ + ++ E+R+ +++ + K + Q ++ EL
Sbjct: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLEL- 3591
Query: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA--- 2308
+ + D+ + ++ + K L + + L Q + HS+ EL
Sbjct: 3592 --LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3649
Query: 2309 -KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-SKFSYEQLETDLQAS 2366
K+E EL S + Q+ + + + L+ + +A + + ++ S LE +
Sbjct: 3650 DKVEVELLSYETQVLK-GEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRA 3708
Query: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
RE ++ E N + + + ++ K E I AI LR Q + + E E E+ ++
Sbjct: 3709 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAI--LRSQQFDQAADAELSWITETEKKLM 3766
Query: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS------------MSSLQNDRD 2474
+ + D+T+ ++ KT E ++ K +D VKS S++ D
Sbjct: 3767 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLD 3826
Query: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534
+++ +Y + I E+ ++ A + N+ E L + + S ++L A +
Sbjct: 3827 KVLKNYDTI----CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPAL 3882
Query: 2535 QY------REDLNQV----------ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
+Y +E+ Q+ I + QLLE+ + ++ KY +
Sbjct: 3883 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY-- 3940
Query: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
+ ED+++ AL E ++ + + + L R V L++ ++ ++K +
Sbjct: 3941 -SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 3999
Query: 2639 EE-------VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
E + +L L+ + ++R E+ K+ + K ++DKL + +
Sbjct: 4000 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA--VQDKLDQMV------- 4050
Query: 2692 GIMRNETETAEERVAELARDLVEMEQK-------LLMVTKENKGLTAQIQSFGRSMSSLQ 2744
I N EER A+L D++E+ +K L++ K+ + ++ G S ++
Sbjct: 4051 FIWENIHTLVEEREAKLL-DVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4109
Query: 2745 NSRDHA---NEELDELKRKYDASLKELAQL------KEQGLLNRERDALLSETAFSMNST 2795
++ A EE+D L+ + D + ++L ++ ++ + D L S S+N
Sbjct: 4110 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKA 4168
Query: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
++ + LE+ Q + + L + ++ + ++ S S L+ + + EL++F
Sbjct: 4169 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI-EELKQF 4227
Query: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH 2915
KSE +Q+ E++ L Q + +++TE
Sbjct: 4228 -KSEAYQQQI------------------------------EMERLNHQAELLLKKVTE-- 4254
Query: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975
++ QD +++ + L + ++ QH+L + Q+ A+
Sbjct: 4255 --ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG-----------QFQHALD 4301
Query: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035
+ L+H + L+ E + + ++++ + + Q+ V L
Sbjct: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL--AHQSTVEAVNKAGNDLI 4359
Query: 3036 DSL--KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVL 3093
+S +E + +++ LN + +LE+ QL +LR+ + +G++ + L
Sbjct: 4360 ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL---DGALRQAKGFHGEIEDLQQWL 4416
Query: 3094 EKQVQELQAGPLNIDVAPGAPQEKNGVHRK--SDPEELREPQQSFSEAQQQL-------- 3143
+ L A + P +E+ VH + + E E +S + QQ+
Sbjct: 4417 TDTERHLLASK-PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSA 4475
Query: 3144 -CNTRQEVNELRKLLE----EERDQRVAAENALSVAEE 3176
N Q++N L++ E + +++ E AL++A E
Sbjct: 4476 ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4513
Score = 204 bits (520), Expect = 9e-52
Identities = 660/3577 (18%), Positives = 1381/3577 (38%), Gaps = 604/3577 (16%)
Query: 37 ESDMEFNNTTQED-----VQERLAYAEQLVVELKDIIRQKDVQLQQKD--------EALQ 83
+S + N T+E+ VQ+ L + +++ V+L D+ + A++
Sbjct: 590 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 649
Query: 84 E-ERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK-HD--KSS 139
E E + KI ++++ A KLT K + +++Q +L T E L H+ +
Sbjct: 650 EFESSLKEAKISEIQMTAPLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 708
Query: 140 TEE-----EMEIEKIKHKLQEKEELISTLQ---AQLTQA--QAEQPAQSSTEMEEFVMMK 189
T E E E E++ + E+ I+ + A+L + Q E+ +S E+ E ++++
Sbjct: 709 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 768
Query: 190 QQLQEK--EEFISTLQAQLSQT-QAEQAAQQVVREKDARFE--------TQVRLHEDELL 238
E + + +Q Q S Q Q +Q ++E A FE T + + +
Sbjct: 769 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 828
Query: 239 QLVTQADVETEMQQKLRVLQRKLEEHEE---------SLVGRAQVV-------------- 275
Q D + + + ++Q +EE EE +L+G+A+ +
Sbjct: 829 QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKT 888
Query: 276 --------DLLQQELTAAEQRNQILSQQLQQM----------EAEHNTLRNTVETEREES 317
D Q E+T + +L+ + EA ++ TV +E+
Sbjct: 889 SIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEA 948
Query: 318 KILLEKMELEVAERKLSFHNLQEEM------HHLLEQFEQAGQAQAELESRYSALEQKHK 371
L ++E + +H M H+L+ + ++
Sbjct: 949 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRI------------------- 989
Query: 372 AEMEEKTSHILSLQKT-GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
+ S++ S++ E Q L+ + L+D E V S I QLE ++
Sbjct: 990 -----RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVC 1044
Query: 431 SKEISQFLNRLPL-QQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL 489
+ + L +Q E+ +V N + E+ Q R ++ +
Sbjct: 1045 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 1104
Query: 490 SSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV-- 547
E E+LK E E+L + + N+ E + + S V + ++ V
Sbjct: 1105 RITEQEKLKKELERLKDDLGTI--TNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYS 1162
Query: 548 LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQ--KEMKQMEGEG 605
+ +T+ K K ++++L + A+ + + +L + A AD ++ +KQ E
Sbjct: 1163 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE- 1221
Query: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665
+++ Q F + +E ++K +A ++ +T +E L
Sbjct: 1222 ---------VDEKRQVFHALEDE------LQKAKAISDEMFKTYKERDL----------- 1255
Query: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN---LDEKAKEISNLN 722
D D + + Q+ ++ +++ +LE K+ + Y LD+ +++
Sbjct: 1256 -DFDWHKEKADQLVERWQNVHVQIDNRLRDLE-GIGKSLKYYRDTYHPLDDWIQQVETTQ 1313
Query: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVK-ELSMVTELRAQVKQLEMNLAEAERQRR 781
+ I+E N NS ++ L+S+++ + S + E + +Q +
Sbjct: 1314 RKIQE---NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK------- 1363
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL--------- 832
DYE QT + + ++ + +++ E D++ +++ TL
Sbjct: 1364 -DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1422
Query: 833 --IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
++ L+ + ++ E E E E+ + + V +S+ L E ++
Sbjct: 1423 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1482
Query: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950
T ++ + E Q + +KM +EE+ L ++KTL+E NLL +E K+ Q
Sbjct: 1483 TKKEQLSEALQTIQLFLAKHGDKMT--DEERNELEKQVKTLQESYNLLF-SESLKQLQ-- 1537
Query: 951 EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL-LQRV 1009
+++ S +K ++ Q KE+LQ DLL + + +A +I + L++
Sbjct: 1538 -ESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY 1596
Query: 1010 SRLEEELANLKDESKKEIPLSET---------ERGE--VEEDKENKEYSEKCVTSKCQEI 1058
+EEL KD L+E E GE +EDK E KC+++
Sbjct: 1597 QSKQEELQ--KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1654
Query: 1059 EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN-QIDLLQAEISE 1117
+ +Q+ E + + K+ EK+AA +Q + ++ L +N D +A
Sbjct: 1655 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1714
Query: 1118 NQAIIQKLITSNTDASDGDSVALVKET-----VVISPPCTGSSEHWKPELEEKILALEKE 1172
Q I Q + T +GD + + E ++ G + L ++ ++ +
Sbjct: 1715 KQVIEQ----NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1770
Query: 1173 KEQLQKKLQE---ALTSRKAILKK-----AQEKERHLREELKQQKDDYNRLQEQFDEQSK 1224
E++ + Q A S + +L+K + E++ L++ +K+ K Y + +++ K
Sbjct: 1771 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK 1830
Query: 1225 ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
++ ++L + E S + E+ + L T+ + +
Sbjct: 1831 LTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM-------TKLKRQKSF 1883
Query: 1285 CPDWPSHSEDASALQ-GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343
D SH D + G V + + + KV+ +L ++ L
Sbjct: 1884 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1943
Query: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
+ N G ++ L E + L L++ + + +HL E + K + +
Sbjct: 1944 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS--KHLSE---PIAVDPKNLQR 1998
Query: 1404 KEEDVSYLSGQLSEKEAALTKIQ--TEII---------EQEDLIKALHT---QLEMQAKE 1449
+ E+ L GQ+S ++ A+ K++ E++ + D+ K L + E +K
Sbjct: 1999 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2058
Query: 1450 HDERIKQLQVELCEMKQKPEEIGE--------ESRAKQQIQRKLQAALISRKEALKENKS 1501
+ER ++LQ+ L + + E ES K+Q Q L + + ++ + +N
Sbjct: 2059 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--QDIISKNIM 2116
Query: 1502 LQEELSLARGTIERLTKSL------ADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
L+++++ + +I + + + D + S Q K KD + R + + + + +M
Sbjct: 2117 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKD-LSARFSEASHKHKETLAKM 2175
Query: 1556 DRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
+ + + + E L+ LE T+ + + K++ L ++E+ E K L+
Sbjct: 2176 EELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2235
Query: 1613 KEYEILLQ------------SYENVSNEAERIQHVVEAVRQEK-------------QELY 1647
+ +L + E +N +++ + + + ++++K Q L
Sbjct: 2236 VLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLV 2295
Query: 1648 GKLRS--TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR--LRAEV 1703
L+S E KK Q +++ + E +K + K E+++ N+ +
Sbjct: 2296 KSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL 2355
Query: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
A T + + + S A + E E +K S+ + +S +DL +
Sbjct: 2356 ISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415
Query: 1764 EGNVSK-QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
+ +++ L +K +++ + Q + + + PT +E+V + N
Sbjct: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKM---NKTATKWQQTPAPTDTEAVKTQVEQN 2472
Query: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF-------------------- 1862
K F + E+ + ++ +LK+++ L EE E
Sbjct: 2473 ----KSFEA--ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL 2526
Query: 1863 ----SQTLENEKNTLLSQISTKDGELKMLQEEVTKM-----------NLLN---QQIQEE 1904
Q LE N L+Q T + +LK E M N+LN QQ+Q
Sbjct: 2527 TIDRQQKLEESSNN-LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2585
Query: 1905 LSRVTKLKETAEE-------------EKDDLEERLMNQLA-------ELNGSIGNYCQDV 1944
L K E+ E L + QLA L G + + C +
Sbjct: 2586 LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWI 2645
Query: 1945 TDAQIKNELLESEMKNLKKCVSELEEE------------------------KQQLVKEKT 1980
A +K+ +S +++L +S+L+ + KQ++ +EK
Sbjct: 2646 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2705
Query: 1981 KVE----------SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
+++ + +++EYL+ Q E K +++ ++ + V+ LQ C
Sbjct: 2706 QIKVAQALCEDLSALVKEEYLKAELSRQLE----GILKSFKDVEQKAENHVQHLQSACAS 2761
Query: 2031 YQEKISALERTVKA-LEFVQTESQKDLEITK--ENLAQAVEHRKKAQAELASFKVLLDDT 2087
+ + R +A L+ + E K I+ + L ++ K L + + + T
Sbjct: 2762 -SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT 2820
Query: 2088 QSEAARVL-----ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
+E +L ++ L+ +L + K + + KQ E E +L+++ EK LK K+ ++
Sbjct: 2821 IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE-RENKLKESLEKALKYKEQVE 2879
Query: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKE-----VQQLQENLDSTVTQLAAFTKSMSSL 2197
+ + + +LE EI+ L+ + E ++ LQ+ +D + + +SL
Sbjct: 2880 TLWPWIDKCQNNLE----EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL 2935
Query: 2198 ----QDDRDRVIDEAKKWERK---FSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIH 2246
+ D++ V DE K +K ++ + SK E + ++ V K+ RQ+
Sbjct: 2936 LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 2995
Query: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQK----------------------------- 2277
E+L I+ S Q + +K T +Q QQK
Sbjct: 2996 KEQLDIHDSL---GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGT 3052
Query: 2278 -----VCDTLQGENKELLSQLEETRHLYHSS-------QNELAKLESELKSLKDQLTDLS 2325
+T+ E+ L Q++E + QN + ++ S+ D+L ++
Sbjct: 3053 SDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMA 3112
Query: 2326 ---NSLEKCKEQKGNLEGIIRQQE---ADIQNSKFSYEQLETDLQASRELT--SRLHEEI 2377
E ++QK ++ +++ E A N+ + + + + S +L R E +
Sbjct: 3113 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEAL 3172
Query: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV-- 2435
+ + K++ +EE ++ I L + + K +KE LL + EE EE++ V
Sbjct: 3173 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSK-LKEFSILLQKAEE-----HEESQGPVGM 3226
Query: 2436 --DKTNQLMETLKTIKKENI---QQKAQ---------LDSFVKSMSS--LQNDRDRIVGD 2479
+ NQ + K +KE I Q K Q + S KS S+ L++D D +
Sbjct: 3227 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNAR 3286
Query: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
++ L ++ + ++ +QEA + ++ + L S M D A +++
Sbjct: 3287 WKTLNKK----VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3342
Query: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR--RSFNALQEEK 2597
Q+ Q+++LL+ L K + EK+ + E + ++ + + L
Sbjct: 3343 KAQI------QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRW 3396
Query: 2598 QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
+ L + E+ + ++ V A Q TL + L E+ + + + + K
Sbjct: 3397 EALLNKAETRNRQLEGIS--VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK---- 3450
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
LEE++ Q +A +ED + KHLH I ++ + ++ + ++ Q
Sbjct: 3451 LEEQI--AQHKA------LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ 3502
Query: 2718 KLLMVTKENKGLTAQI--------QSFGRSMSSLQNSRDHANEELDELK-RKYDA----- 2763
+ +E +++ + FG L N + +++L +L + Y
Sbjct: 3503 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWK 3562
Query: 2764 SLKELAQLKEQGLLNRER--DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS 2821
EL L+E LL ++ ALL+ +T + L +KL + + ++ + + LS
Sbjct: 3563 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL-EAIKARYKDITKLS 3621
Query: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
+ + + Q ++ + S E +++E S E + + S + + LKK
Sbjct: 3622 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3681
Query: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
K K L +++ + EL P +A +E +K A + L +
Sbjct: 3682 E-----------AKNNKALLDSLNEVSSALLELVPWRA--REGLEKMVAEDNERYRLVSD 3728
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001
++ + E + +S + + L I++ +++L L ++ E +S+Q
Sbjct: 3729 TITQKVEEIDAAILRSQ---QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ---- 3781
Query: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL--------RIQQLNS 3053
+Q Q+ + E D +LV + T ++ K+ +K+L I Q+NS
Sbjct: 3782 -LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3840
Query: 3054 NFSQLLEEKNTLSIQLCDT------------------------SQSLRENQQHYGDLLNH 3089
LE +L Q +T ++LR+ Q+ + L
Sbjct: 3841 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3900
Query: 3090 CAVLEKQVQEL-QAGPLNIDVAPGAPQEKNGVHRKSD------PEELREPQQSFSEAQQQ 3142
A + + ++ + GP ++++PG + +D E++++ + EA Q
Sbjct: 3901 IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ 3960
Query: 3143 LCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
+++++ + L E +R+ ++S E+I+
Sbjct: 3961 STQFHDKIDQILESL-ERIVERLRQPPSISAEVEKIK 3996
Score = 176 bits (446), Expect = 3e-43
Identities = 620/3279 (18%), Positives = 1259/3279 (38%), Gaps = 588/3279 (17%)
Query: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER-KAADNKIKKLKLHAKAKLT 105
Q+D+Q ++V ++ +++ +L Q+D+AL E++ A K ++L L A+
Sbjct: 1604 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1663
Query: 106 SLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK-----SSTEEEMEIEKIKHK-------- 152
L+K + + + Q EE +K + S+ +++ E KHK
Sbjct: 1664 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGT 1723
Query: 153 ----------LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ-EKEEFIST 201
+ E++E+ L + + Q T E Q+++ + E+ IS
Sbjct: 1724 HFQEGDGKSAIGEEDEVNGNL------LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1777
Query: 202 LQAQLSQTQAEQAAQQVVREKDARF---ETQVRLHED--ELLQLVTQADVETEMQQKL-R 255
QA + TQ+ Q V+ EK ++ E + +L ++ EL A E+E + KL
Sbjct: 1778 HQAVIIATQSAQ----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 1833
Query: 256 VLQRKLEEHEESLVGRAQVVDLLQQEL----TAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
LQ +LE+ + + +QEL A+ N ++++ +Q + + + +
Sbjct: 1834 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1893
Query: 312 ------------------TEREESKILLEKMELEVAERKLS-----FHNLQEE------- 341
++R+ K+ EV +RKL F +L +
Sbjct: 1894 LRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-QRKLDHATDRFRSLYSKCNVLGNN 1952
Query: 342 MHHLLEQFEQAGQAQAELESRYSALE---QKHKAE------------MEEKTS---HILS 383
+ L+++++ A L + A E KH +E +EE + I S
Sbjct: 1953 LKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISS 2012
Query: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL 443
Q ++L+ + L D LL KN+ IQ+ D + + +++S+ +N
Sbjct: 2013 QQVAVEKLKKTAEVLLDARGSLLPAKND--------IQKTLDDIVGRYEDLSKSVNERNE 2064
Query: 444 QQHETASQT-SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
+ T +++ S D +E + N+ S K E+G + L+S L+++ ++N
Sbjct: 2065 KLQITLTRSLSVQDGLDEMLDWMG--NVESSLK-------EQGQVPLNSTALQDIISKNI 2115
Query: 503 KLSSQITLLEAQ-NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
L I ++ N E ++ E + D + S A+ + S KHKE
Sbjct: 2116 MLEQDIAGRQSSINAMNEKVKKFMETT--DPSTASSLQAKMKDLSARFSEASHKHKETLA 2173
Query: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
+ E+K E L +LQ + + + +++ G ++ +++++ +
Sbjct: 2174 KMEELKTKVELFENLSEKLQTFLETKT-------QALTEVDVPGKDVTELSQYMQESTSE 2226
Query: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
F L ++ KE +S H + + + L K K+ D + C
Sbjct: 2227 FLEHKKHLEVLHSLLKEISS--HGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2284
Query: 682 HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA 741
Q++L+ Q+L L + + + + + +L + +E+ KK + S
Sbjct: 2285 -QEQLDAF--QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPE 2341
Query: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHS 800
+ + + +S +S VT + ++ A + + E A+ L + +
Sbjct: 2342 IQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2401
Query: 801 LSIEAKSKDV------KIEVLQNELDDVQLQFSEQSTLIRSLQSQL-------------- 840
I +D+ KI L +L +Q E S +++ LQ
Sbjct: 2402 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2461
Query: 841 ---------QNK--ESEVLEGAERVRHISSKVEEL-------------SQALSQKELEIT 876
QNK E+E+ + +V+ + K+ EL Q L++ + +
Sbjct: 2462 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQ 2521
Query: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV---------E 927
+++QL +++ QQ +EE +T+ + L E++ + V
Sbjct: 2522 ELNQLTIDR-------QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2574
Query: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ---HEFDLL 984
+ T ++Q+ +L + +K Q E+ G+ E I KE+L ++D L
Sbjct: 2575 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2634
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS----------ETER 1034
+ R + A++ + + L ++L++L ++ + +S ET +
Sbjct: 2635 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2694
Query: 1035 GEVEEDKENKEYSEKCVTSKCQEI-----EIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
+E ++ K+ K + C+++ E YLK +S + + KD+E+K AE
Sbjct: 2695 KMKQEIQQEKKQI-KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQK--AENH 2751
Query: 1090 FQALVK------QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Q L Q Q +D +D + E +++ I KL + L+K+
Sbjct: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES---------LIKD 2802
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEK----EKEQLQKKLQEALTSRKAILKKAQEKER 1199
S T S ++ + E L K EK LQ +L T+ K+ +E+E
Sbjct: 2803 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2862
Query: 1200 HLREEL------KQQKDDY--------NRLQE-QFDEQSKENENIGDQLRQLQ------- 1237
L+E L K+Q + N L+E +F E EN +L+ LQ
Sbjct: 2863 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2922
Query: 1238 --IQVRESIDGKLPST---DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPS-- 1290
+++ + L S D++ L + + TEQ H++ N+ +
Sbjct: 2923 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 2982
Query: 1291 -------------------HSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV------ 1325
H S + ++ Q K ++A K +++L
Sbjct: 2983 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3042
Query: 1326 ------SSTTSELTKKSEEVFQ----LQEQINK---------QGL--------------- 1351
S TS++ + E + Q L +Q+++ QG+
Sbjct: 3043 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3102
Query: 1352 ----EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
E++S+ V +AE +LQ++ E+ + + LE L ++ K++ EE
Sbjct: 3103 EFDDELDSMAPVGRDAE----TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 3158
Query: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE---RIKQLQVELCEM 1464
L G + EA L+K +++ D +A Q+E K +E ++K+ + L +
Sbjct: 3159 SPDLVGIKRDLEA-LSKQCNKLL---DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3214
Query: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS-LARGTIERLTKS---- 1519
++ E G + I ++L + +KE ++ + Q++++ L +G I+ KS
Sbjct: 3215 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3274
Query: 1520 -----LADVESQVSAQNKEKDTVLGRLALLQE--------------------ERDKLITE 1554
L DV ++ NK+ V R A LQE + ++L+
Sbjct: 3275 GLEHDLDDVNARWKTLNKK---VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3331
Query: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
E + + + + KL L+ L +D++ V+ I+ + KIA + E +K K L K+
Sbjct: 3332 QKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKR-EGEKIATTAEPADKVKIL-KQ 3388
Query: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR-------------------STEA 1655
+L +E + N+AE +E + Q+ + L T+A
Sbjct: 3389 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3448
Query: 1656 NKKETEKQLQEAEQE--MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC 1713
+K E + +A ++ + K + + + K+L E+ D +++++ + E
Sbjct: 3449 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3508
Query: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQAN 1772
E S + +++ L K+ E + L D LS+ VQD + EG +Q+
Sbjct: 3509 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGLWKQQSE 3566
Query: 1773 LEATE-----KHDNQTNVTEEGTQSIPGETEEQ--------DSLSMSTRPTCSESVPSAK 1819
L + + N G + + T ++ +++ + S AK
Sbjct: 3567 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
Query: 1820 SANPAVS---KDFSSHDEINNYLQQID-----------------QLKERIAGLEEEKQKN 1859
+ A+ + S+H+E+ +L +++ Q + R L++E + N
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686
Query: 1860 KEFSQTLENEKNTLLSQIS--TKDGELKMLQEEVTKMNLLNQQIQEELSRVTK--LKETA 1915
K +L + LL + ++G KM+ E+ + L++ I +++ + L+
Sbjct: 3687 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3746
Query: 1916 EEEKDDLEERLMNQLAELNGSIGNYC--QDVTDAQIK-NELLESEMKNLKKCVSELEEEK 1972
++ D E + + + S+G+ QD T AQ++ + E+ K + +L +
Sbjct: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
Query: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ 2032
+++ ++ E + K+ L+K+ K + + + QL+ R Q
Sbjct: 3807 HKIMTACSEEEKQSMKKKLDKV------------LKNYDTICQINSERYLQLE----RAQ 3850
Query: 2033 EKISALERTVKALEFVQTESQKDLE------ITKENLAQAVEHRKKAQAELASFKVLLDD 2086
++ T + L TE+Q + + E L Q E ++ + +A K +D
Sbjct: 3851 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3910
Query: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLD 2146
++L + +Q + + Q ED+++R +E + + +K+D
Sbjct: 3911 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEA-ISQSTQFHDKID 3969
Query: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206
+ + E + + + +K +Q+ EN + +V
Sbjct: 3970 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSV---------------------- 4007
Query: 2207 EAKKWERKFSDAIQSKEEEIRL-----KEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
+ +K + + Q EE I K+ + ++D+L QM E NI L ++
Sbjct: 4008 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE----NIHTLVEER 4063
Query: 2262 QIWESKAQTEVQLQQKV-CDTLQ-----GENKELLSQLEETR---HLYHSSQNELAKLES 2312
E+K ++L +K CD + + ++ + LE+ + Q +
Sbjct: 4064 ---EAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4120
Query: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS---------KFSYEQLETDL 2363
E+ L+++L + N + G + I ++ D NS K ++LE +
Sbjct: 4121 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4180
Query: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE 2423
QA+ + L + + ++G + A I + ++I+EL+ S+ ++
Sbjct: 4181 QAAVQYQDGLQAVFDWVD------IAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQ 4234
Query: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
I +E N +A +L+ LK + +E+ + Q D ++ + +RI+ +L
Sbjct: 4235 QIEMERLNHQA-----ELL--LKKVTEESDKHTVQ-DPLMELKLIWDSLEERIINRQHKL 4286
Query: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
E L++ Q A E GL S + + ++ EL ++ N V
Sbjct: 4287 EGALLAL-----GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
Query: 2544 ITIKDSQQ------KQLLEVQL-QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
+ + + + L+E ++ L+NK L ++ + E E ++ + +
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTL-GLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
+ EIE L+ ++ R + A + G L QL V E A + + +
Sbjct: 4402 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4461
Query: 2656 AELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD---- 2711
+ ++ L K A + + + LK++ + + NE +T E LA +
Sbjct: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVE----TKLNERKTKLEEALNLAMEFHNS 4517
Query: 2712 -------LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
L + EQ L + ++ + L + H E++ EL K
Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH-REQIIELD-KTGTH 4575
Query: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
LK +Q ++ L+ ++ L+S S EK+ Q+L+ + L
Sbjct: 4576 LKYFSQKQDVVLI---KNLLISVQ------------SRWEKVVQRLVER-------GRSL 4613
Query: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
+D+ + + F +A + L W LE+ KS + + A P ++ K+
Sbjct: 4614 DDARKRAKQFHEAWSKLME-----W--LEESEKSLDSELEIANDPDKIKTQLAQHKEFQK 4666
Query: 2885 SL---------QNDRDRLLKELKNLQQQYLQINQEITEL 2914
SL N R LKE +L L+++ ++EL
Sbjct: 4667 SLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4705
Score = 156 bits (395), Expect = 3e-37
Identities = 482/2513 (19%), Positives = 1005/2513 (39%), Gaps = 376/2513 (14%)
Query: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA---QLTQAQAEQ--PA 176
L + S +S H + ++ +K+K ++Q++++ I QA L+ E+ A
Sbjct: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA 2728
Query: 177 QSSTEMEEFVMMKQQLQEK-EEFISTLQ-AQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
+ S ++E + + +++K E + LQ A S Q +Q ++ D + E Q + H
Sbjct: 2729 ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP 2788
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
+ KL VL+ +++H++ + E T AE N +L
Sbjct: 2789 ---------------ISAKLDVLESLIKDHKD--FSKTLTAQSHMYEKTIAEGENLLLKT 2831
Query: 295 QLQQ---MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQ 351
Q + ++ + NT++ +T ++ K K++ E E+ L + E + +++ +
Sbjct: 2832 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLK-ESLEKALKYKEQVETLWPWIDKCQN 2890
Query: 352 AGQA------QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405
+ AE E+ + L+ K EM++ + L T L S C+ K+ +
Sbjct: 2891 NLEEIKFCLDPAEGENSIAKLKSLQK-EMDQHFGMVELLNNTANSLLSVCEIDKE----V 2945
Query: 406 LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465
+ D+N+ +Q + + +QL K + + + Q V
Sbjct: 2946 VTDENKSLIQK---VDMVTEQLHSKKFCLENMTQKF------------------KEFQEV 2984
Query: 466 TEENIASLQ--KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
++E+ LQ K +++ + G+ S+ L L+ + + L +A + +
Sbjct: 2985 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-------QALKHQVDLAKR 3037
Query: 524 VSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581
+++ +V+ ++ + +S DVL T +Q+H LS ++ E+ +FL+ +LQ
Sbjct: 3038 LAQDLVVEASDSKGTS------DVLLQVETIAQEHSTLS------QQVDEKCSFLETKLQ 3085
Query: 582 G-KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE-- 638
G + E+ Q E + +AP+ G+D + ++ ++ A K+
Sbjct: 3086 GIGHFQNTIREMFSQFAEFDDELDSMAPV---------GRDAETLQKQKETIKAFLKKLE 3136
Query: 639 --QASTEHQSRTSEE-ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
AS ++ ++T + ++ + +L K+D L A+ QC++ L+R +++ +
Sbjct: 3137 ALMASNDNANKTCKMMLATEETSPDLVGIKRD----LEALSK--QCNK-LLDRAQAREEQ 3189
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755
+E + +E Y K KE S L Q EE +++ +E +Q L+ K
Sbjct: 3190 VEGTIKRLEEFYSK-----LKEFSILLQKAEEHEES----QGPVGMETETINQQLNMFKV 3240
Query: 756 LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815
Q KQ ++N Q + +++ L + ++ K+ + K+
Sbjct: 3241 FQKEEIEPLQGKQQDVNWLG---QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
Query: 816 QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG---AERVRHISSKVEELSQALSQKE 872
+L + L + SL S + + E V + + + ++++E Q L Q+
Sbjct: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE--QKLLQRL 3355
Query: 873 LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932
L+ K ++ KR+ E + T E D+ + +++ L+ +L + +T
Sbjct: 3356 LDDRKSTVEVI--KREGEKIATTAEPADK------VKILKQLSLLDSRWEALLNKAETRN 3407
Query: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG-QISKEELQHEFDLLKKENEQR 991
QL +S + E +E NE + +++ P G Q SK E E +
Sbjct: 3408 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE----------EQIAQ 3457
Query: 992 KRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV---EEDKENKEYSE 1048
+ L+ +IN + L + + + L L K++ S+ + +V E +++ SE
Sbjct: 3458 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3517
Query: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA----EEQFQALVKQMNQTLQDK 1104
+ C + E EVEL + ++ +KL+ + + L KQ ++ +
Sbjct: 3518 LLQQALCNA------KIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL---R 3568
Query: 1105 TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP----CTGSSEHWKP 1160
Q D+L + + +QA++ L + GD V ++++ + T S
Sbjct: 3569 VLQEDILLRKQNVDQALLNGL--ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
Query: 1161 ELEEKILA---LEKEKEQL----QKKLQEALTSRKAILKKAQEKERHLR-EELKQQKDDY 1212
LE+ + L E+L K E L+ +LK + + +R +ELK++ +
Sbjct: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686
Query: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE----SCSSTPGLEEPLF 1268
L + +E S L + + RE ++ K+ + D + S + T +EE
Sbjct: 3687 KALLDSLNEVSSA------LLELVPWRAREGLE-KMVAEDNERYRLVSDTITQKVEEIDA 3739
Query: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ--IKAQLKEIEAEKVELELKVS 1326
++ L W + +E G + Q AQL+ + +E+ L+
Sbjct: 3740 AILRSQQFDQAADAEL--SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI-LRHK 3796
Query: 1327 STTSELTKKSEEVFQLQEQINKQGLEIES---LKTVSHEAEVHAESLQQKLESSQLQIAG 1383
+L K ++ + KQ ++ + LK ++++E Q + L
Sbjct: 3797 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQF 3856
Query: 1384 LEHLRELQPKLDELQKLISK-------------KEEDVSYLSGQLSEKEAALTK------ 1424
E EL P L E Q +IS+ ++E+ L ++E + + K
Sbjct: 3857 WETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3916
Query: 1425 ------------IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ---LQVELCEMKQKPE 1469
IQ + + + L + ++ +A DE I Q ++ ++ + E
Sbjct: 3917 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 3976
Query: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
I E R I +++ KE + ENK++ ++ + E L + ++ ++
Sbjct: 3977 RIVERLRQPPSISAEVEKI----KEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4032
Query: 1530 QNKEKDTV-----LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
+K+ L ++ + E L+ E + LL+ L+ ++L +D +
Sbjct: 4033 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4092
Query: 1585 KLVKEIES--LKSSKIAESTEWQEKHKE----LQKEYEILLQ-SYENVSNEAERIQHVVE 1637
++++E + S + + E E +E LQ+E +I++ E ++ E + +V+
Sbjct: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
Query: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
E + L K+ +L+EA Q + ++ + Q + + +
Sbjct: 4153 KSIDELNSAWDSLNKAW---KDRIDKLEEAMQAAVQYQDGL--------QAVFDWVDIAG 4201
Query: 1698 RLRAEVHPAG---DTAKECMETL--LSSNASMKE-ELERVKMEYETLSKKFQS------- 1744
A + P G +T K+ +E L S A ++ E+ER+ + E L KK
Sbjct: 4202 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 4261
Query: 1745 ---LMSEK---DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPG 1795
LM K DSL E + + +H++EG + + EG Q G
Sbjct: 4262 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321
Query: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSK------DFSSHDEINNYLQQIDQLKERI 1849
+ + ++ V + +S AV+K + S+ +E +N +++ L +R
Sbjct: 4322 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4381
Query: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK----------MNLLNQ 1899
+ E+ ++ K+ + + L Q GE++ LQ+ +T + L +
Sbjct: 4382 QNVLEKTEQRKQ-------QLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434
Query: 1900 QIQEELS---RVTKLKETAEEEKDDLEERLMNQLAELNGSIG-NYCQDVTDAQIKNELLE 1955
+E+L+ V E EE L ++ LA S N QD+ + + K E +E
Sbjct: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4494
Query: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+++ K ++LEE ++ ++ +++ + A++ S + + +
Sbjct: 4495 TKLNERK---TKLEEALNLAMEFHNSLQ-----DFINWLTQAEQTLNVASRPSLILDTVL 4546
Query: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR-KKAQ 2074
+ E K + ++E+I L++T L++ SQK + +NL +V+ R +K
Sbjct: 4547 FQIDEHKVFANEVNSHREQIIELDKTGTHLKYF---SQKQDVVLIKNLLISVQSRWEKVV 4603
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
L LDD + A + KL + L+ +++S+ S+++ ++ + + + A+ K
Sbjct: 4604 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4663
Query: 2135 LKEKKNMQEKL-DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
++ + + D R L+E L K D + +L++ D+ +
Sbjct: 4664 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSV----- 4717
Query: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEE-----EIRLKE---------------DNC 2233
+R ++EA + +F+DA+Q+ + E +L E DN
Sbjct: 4718 ------ERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4771
Query: 2234 SVLKDQLRQMSIHMEELKINISRL---EHDKQIWESKAQTEVQLQ-QKVCD---TLQGEN 2286
+ +L + + ++ LK + L D W E+ + + VC + Q
Sbjct: 4772 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4831
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
+ L Q EE + H+ LA+ E L+ L D ++L +Q + ++
Sbjct: 4832 EAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKR 4890
Query: 2347 ADIQNS--------KFSYEQLETDLQASRELTSRLHEEI----NMKEQKIISLLSG---K 2391
A++ + + T ++ + EE+ +Q++ S L+G K
Sbjct: 4891 AELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4950
Query: 2392 EEAIQVAIAELR------QQHDKEI--KELENLLSQEEEENIVLEEENKKAVD 2436
+E ++ +A L+ DKE+ +E+E + + E +EE +K D
Sbjct: 4951 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD 5003
Score = 129 bits (324), Expect = 5e-29
Identities = 476/2605 (18%), Positives = 1047/2605 (40%), Gaps = 386/2605 (14%)
Query: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQE------RLAYAEQLVVELKDIIRQK--D 72
D D + + L H ++ + T Q+ QE ++ A+ L +L +++++
Sbjct: 2668 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2727
Query: 73 VQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132
+L ++ E + + K + K + H ++ S +++ ++M L T+ EEQ
Sbjct: 2728 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF-QQMSRDFQAWLDTK--KEEQN 2784
Query: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192
H S+ +++ ++ +++ ++ TL AQ M ++ +
Sbjct: 2785 KSHPISA-----KLDVLESLIKDHKDFSKTLTAQSH------------------MYEKTI 2821
Query: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252
E E + L+ Q S+ A Q ++ F QV+ E++L + + +A + ++
Sbjct: 2822 AEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA---LKYKE 2876
Query: 253 KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN--QILSQQLQQMEAEHNTLRNTV 310
++ L +++ + +L +D + E + A+ ++ + + Q +E +NT + +
Sbjct: 2877 QVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2936
Query: 311 -------ETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG-QAQAELESR 362
E +E+K L++K+++ V E+ S E M ++F++ +++ +L+
Sbjct: 2937 SVCEIDKEVVTDENKSLIQKVDM-VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 2995
Query: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS------ 416
L+ + ++ L++ +T Q+ A D +L QD +A S
Sbjct: 2996 KEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV 3055
Query: 417 ---AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE-ENIAS 472
+TI Q L Q+ E FL Q Q + +++++ + E +++A
Sbjct: 3056 LLQVETIAQEHSTLSQQVDEKCSFLETK--LQGIGHFQNTIREMFSQFAEFDDELDSMAP 3113
Query: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE----ADREVSEIS 528
+ + L+ +K + +LE L A N+ + ++ A T R++ +S
Sbjct: 3114 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3173
Query: 529 -----IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
++D A R E + + + E F K KE S+LL + +E +E + ++ +
Sbjct: 3174 KQCNKLLDRAQAREEQVEGTIKRLEE--FYSKLKEFSILLQKAEEHEESQGPVGMETETI 3231
Query: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
+ +V ++E++ ++G+ + + GQ + +S +E +
Sbjct: 3232 NQQLNMFKVFQKEEIEPLQGK-------QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVN 3284
Query: 644 HQSRTSEE------ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD------ELERLKS 691
+ +T + L +A + + + LS + D + + E + +K+
Sbjct: 3285 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA 3344
Query: 692 QILELEL------NFHKAQEIYEKNLDEKA------------KEISNLNQLIEEFKKNAD 733
QI E +L + E+ ++ ++ A K++S L+ E A+
Sbjct: 3345 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3404
Query: 734 NNSSAFTALSEERDQLLSQVKELS-MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
+ +S Q ++ L+ +T + ++ E +A + + + D+
Sbjct: 3405 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3464
Query: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
++ H + + +K+ + + D VQ + +Q + ++ SE+L+ A
Sbjct: 3465 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR-SELLQQAL 3523
Query: 853 RVRHISSKVE-ELSQALSQKELEITKMD------QLLLEKKRDVETLQQTIEEKDQQVTE 905
I + E EL L++ +++K+ + L +++ ++ LQ+ I + Q V +
Sbjct: 3524 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3583
Query: 906 ISFSMTEKMVQLN-EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
+ E + Q +E + +++ +K + +++ + +E+ +++ L ++
Sbjct: 3584 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3643
Query: 965 EMSP-AGQISKEELQHEFDLLKKEN----EQRKRKLQAALINRKELLQRVSRLEEELANL 1019
E+ ++ E L +E +LK E + R ++L+ N K LL ++ + L L
Sbjct: 3644 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3703
Query: 1020 KDESKKEIPLSETERGE--VEEDKENKEYSEKCVTSKCQEIEIYL---KQTISEKEVELQ 1074
+P E E V ED E +T K +EI+ + +Q + EL
Sbjct: 3704 -------VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS 3756
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQ-DKTNQIDLLQAEISENQAIIQKLITSN---- 1129
I + E+KL + + Q + LQ KT +++L+ ++ II L+ S
Sbjct: 3757 WIT-ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR-----HKDIIDDLVKSGHKIM 3810
Query: 1130 TDASDGDSVALVKETVVI----SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
T S+ + ++ K+ + C +SE + E+ +L + + ++L LT
Sbjct: 3811 TACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL--ERAQSLVNQFWETYEELWPWLT 3868
Query: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI---GDQLRQLQIQVRE 1242
++I+ + E L+QQ++++ +L+E E + + G QL +L
Sbjct: 3869 ETQSIISQLPAPALEY-ETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3927
Query: 1243 SIDGKLPSTD------QQESCSSTPGLEEPLFKATEQHHT-QPVLESNLCPDWPSHSEDA 1295
SI K + D +++ L+E + ++T+ H +LES
Sbjct: 3928 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES------------- 3974
Query: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ---EQINKQGLE 1352
+ +I +L++ + E+E K+ SE S ++ +LQ E + ++G E
Sbjct: 3975 --------LERIVERLRQPPSISAEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEE 4025
Query: 1353 IESLKTVSHEAEVHAESLQQKLESS-----------QLQIAGLEHLRELQPKL--DELQK 1399
+ + ++ + ++ A+++Q KL+ + + A L + EL K D +
Sbjct: 4026 MIA-RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 4084
Query: 1400 LISKKE--------EDVSYLSGQLSEKEAALTKIQTEII---EQEDLIKALHTQLEMQAK 1448
+++ K+ ED + +++ A I+ EI E+ D++ L ++L
Sbjct: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG 4144
Query: 1449 EHDERIKQLQVELCEM---------KQKPEEIGEESRAKQQIQRKLQAA----------- 1488
E D+ I + ++ K + +++ E +A Q Q LQA
Sbjct: 4145 EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4204
Query: 1489 ---------LISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV-- 1537
L + K+ ++E K + E + +ERL A++ + + +K TV
Sbjct: 4205 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEESDKHTVQD 4263
Query: 1538 -LGRLALLQEERDKLIT----EMDRSLLENQSLSSSCESLKLAL---EGLTEDKEKL--- 1586
L L L+ + ++ I +++ +LL + + L L EGL +++ +
Sbjct: 4264 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4323
Query: 1587 --VKEIESLK---------------------SSKIAESTEWQEKHKELQKEYEILLQSYE 1623
EIE K + + ES+ +E LQ + E+L Q ++
Sbjct: 4324 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA-SNLQNKLEVLNQRWQ 4382
Query: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
NV + E+ + ++ ++ + +G++ + +TE+ L A + + + E ++
Sbjct: 4383 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL-ASKPLGGLPETAKEQLN 4441
Query: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
+ E + + ++ + C + S+ ++ +++ +K ++E++ K
Sbjct: 4442 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPK---SAETNIDQDINNLKEKWESVETK-- 4496
Query: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQAN-LEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
++E+ + EE +L + ++ N L E+ N + ++ + +E
Sbjct: 4497 --LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554
Query: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI-----------NNYLQQIDQLKERIAG 1851
+ + + K+ K FS ++ + + + + +L ER
Sbjct: 4555 FANEVNSHREQIIELDKTGTHL--KYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4612
Query: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ--EEVTKMNLLNQQIQEELSRVT 1909
L++ +++ K+F + L + D EL++ +++ +++ Q+ L
Sbjct: 4613 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4672
Query: 1910 KLKETAEEEKDDLEE---------RLMNQLAELNGSIGNYCQDVTDAQIKNE---LLESE 1957
+ +T L+E +L + L+EL C + Q K E L +
Sbjct: 4673 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4732
Query: 1958 MKN-LKKCVSELEEEKQQLVKEK-TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+ L+ + L + QL +++ + ++ ++ + QKE G ++ + + LK
Sbjct: 4733 FTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS---VQALK 4789
Query: 2016 EKQQEVKQLQKDCIRY----QEKISALERTVKALEF-VQTESQKDLEITKE--NLAQA-V 2067
+E+ + +D + +++S TV AL QT + L +E ++ A +
Sbjct: 4790 RSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL 4849
Query: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLK-LKKELQSNKESVKSQMKQKDEDL--- 2123
E +A+ L VL DD +A R L D K K+L+ + + D L
Sbjct: 4850 EWLAEAEQTLRFHGVLPDD--EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAIC 4907
Query: 2124 ---------------ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ---VT 2165
R E+ + ++ + L L ++ LE + +Q T
Sbjct: 4908 HPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETT 4967
Query: 2166 LNKKDKEV-QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSD--AIQS- 2221
L KDKEV Q E + + + + F + M+ Q D D+V K ++R+ +D ++QS
Sbjct: 4968 LTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV---TKTYKRRAADPSSLQSH 5024
Query: 2222 ----KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK 2277
+ K S L Q I + ++N+ + +Q+W + +L
Sbjct: 5025 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL-LVSKWQQVWLLALERRRKL--- 5080
Query: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE-LKSLKDQLTDLSNSLEKCKEQKG 2336
+ L +LEE R + + K + K ++ D ++K ++ K
Sbjct: 5081 ---------NDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGK- 5130
Query: 2337 NLEGIIRQQEAD-IQNSKFSYEQLE 2360
I RQ+ D I +SKF +LE
Sbjct: 5131 ----ITRQEFIDGILSSKFPTSRLE 5151
Score = 68.9 bits (167), Expect = 8e-11
Identities = 263/1488 (17%), Positives = 567/1488 (38%), Gaps = 262/1488 (17%)
Query: 1900 QIQEELSRVTKLKETAEEEKDDLE--ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
QI++ L + + L + EE+ +++ + L+N + E+ + D T+ +ES
Sbjct: 583 QIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL-----DRTEWGSDLPSVESH 637
Query: 1958 M---KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
+ KN+ + + E E ++ + ++ + ++ Y EK+ + S +L
Sbjct: 638 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE------SQYAKLLNTS 691
Query: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
+ +++ + L R ++ L E + E D N+A+ ++ +
Sbjct: 692 RNQERHLDTLHNFVSRATNELIWLN------EKEEEEVAYDWSERNTNIARKKDYHAELM 745
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
EL + + Q A ++L +N + +++ + ++++Q +L Q E+H
Sbjct: 746 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQW-----SWILQLCQCVEQH 800
Query: 2135 LKEK-------KNMQEKLDALRREKVHLEETIG-EIQVTLNKKDKEVQQLQENLD----- 2181
+KE + +E D LR K ++ + +++K + VQ+ E +
Sbjct: 801 IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY 860
Query: 2182 -STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL-KEDNCSVLKDQ 2239
ST+ L K++ L + R D K ++ EI + K+D C + +
Sbjct: 861 KSTIANLMGKAKTIIQL---KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 917
Query: 2240 LR------------------------------QMSIHMEELKINISRLEHDKQI------ 2263
R ++ +E+ N+ L H+ I
Sbjct: 918 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVV 977
Query: 2264 -WESKAQTEVQLQ----QKVCDTLQGENKELLSQ--------LEETRHLYHSSQNELAKL 2310
W +++ + L GE++++LS LE+++ S +++ +L
Sbjct: 978 SWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 1037
Query: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE--------QLETD 2362
E E+ K +L S E+ +++ E + ++++N + E Q+ T
Sbjct: 1038 EKEVNVCKQYYQELLKSAEREEQE----ESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1093
Query: 2363 LQAS--RELTSRLHEEINMKEQ-----KIISLLSGK------EEAIQVAIAELRQQHDKE 2409
L+ E R+ E+ +K++ + ++ K + A ++ LR + +
Sbjct: 1094 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1153
Query: 2410 IKELENLLSQ-----EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
++ + + S ++ + + L +N +A + +L ET ++ I K +++ +
Sbjct: 1154 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 1213
Query: 2465 SMSSLQNDRD----------------RIVGD--YQQLEERHLSIILEK---DQLI---QE 2500
++ +++ D + + D ++ +ER L K DQL+ Q
Sbjct: 1214 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 1273
Query: 2501 AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560
+ + ++ G+ + LD + IQ E + I + + L QL
Sbjct: 1274 VHVQIDNRLRDLEGIGKSLKYYRDTYHPLD-DWIQQVETTQRKIQENQPENSKTLATQLN 1332
Query: 2561 QNK----ELENKYAKLEEKLKESEEANEDLR------RSFNALQEEKQDLSKEIESLKVS 2610
Q K E+E K +K++E K +E+ + ++ ++ A+ + +Q + ++ S
Sbjct: 1333 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1392
Query: 2611 ISQLTRQVTALQEEGT--LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
+ ++ L+ T + L +K + + RL +K + E ++E V KE
Sbjct: 1393 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL----EEEEKSLEEEKKEHVEKAKE 1448
Query: 2669 AAKKVGEIEDKLK---KELKHLHHDAGIMRNETETAEERVAELAR--DLVEMEQKLLMVT 2723
K V I LK K K I E T +E+++E + L + M
Sbjct: 1449 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1508
Query: 2724 KENKGLTAQIQS--------FGRSMSSLQNSRDHANEELD-----ELKRKYDASLKELAQ 2770
+E L Q+++ F S+ LQ S+ + +++ E +++Y L+ +
Sbjct: 1509 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1568
Query: 2771 L---KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
L E L+ + ++ + + + + + + E + + + L+++
Sbjct: 1569 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1628
Query: 2828 YNQVQSFSKAM-------ASLQNERDHLWNELEKFR---------KSEEGKQRSAAQPST 2871
++ KA+ A ++ E+ +L E K K E K + Q
Sbjct: 1629 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1688
Query: 2872 SPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE------ITELHPLKAQLQEYQ 2925
S ++++L +S++ D +R + K + +Q QE I E + L E
Sbjct: 1689 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-T 1747
Query: 2926 DKTKAFQIMQEELRQ--ENLSWQHE----LHQLRM--------------------EKSSW 2959
D QE L Q + + QHE HQ + EK
Sbjct: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1807
Query: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASP 3017
+ + + +K Y A+++ ++++ +L EL + + +Q Q A
Sbjct: 1808 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1867
Query: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQ---LCDTSQ 3074
D L+ + + ++ D + H+ +LR ++ N ++LE + S + DTS
Sbjct: 1868 DDINGLMTKLKRQKSFSEDVIS--HKGDLRYITISGN--RVLEAAKSCSKRDGGKVDTSA 1923
Query: 3075 SLRENQQ-------HYGDLLNHCAVLEKQVQEL----------QAGPL-NIDVAPGAPQE 3116
+ RE Q+ + L + C VL +++L G L + +
Sbjct: 1924 THREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK 1983
Query: 3117 KNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR 3164
DP+ L+ + Q Q+ + + V +L+K E D R
Sbjct: 1984 HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDAR 2031
Score = 33.9 bits (76), Expect = 2.7
Identities = 56/307 (18%), Positives = 134/307 (43%), Gaps = 24/307 (7%)
Query: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
N+ +L+Q R+ L + + + ++ E+ ++ ++L N +++ +L +E ++
Sbjct: 574 NSLQTLKLMQIRKPLLKSSLLDQNLTEE--EINMKFVQDLLNWVDEMQVQLDRTEWGSD- 630
Query: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
S + E +++ + IE + S+ + +++ +Q L L +A E++HRL
Sbjct: 631 -LPSVESHLENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYA------EKLHRLE 681
Query: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV 2705
+ ++ E L + ++ E+ +KE + + +D ++
Sbjct: 682 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 741
Query: 2706 AELARDLVEMEQKLLMVTK-------ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
AEL R+L + E+ + V + EN I+++ +M + + + +++
Sbjct: 742 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 801
Query: 2759 RKYDASLKELAQLKE-QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQL 2817
++ A + KE L +DA+ + + +S S+ LE L Q+ + + E+L
Sbjct: 802 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS----SIHKLEDLVQESMEEKEEL 857
Query: 2818 LHLSSQL 2824
L S +
Sbjct: 858 LQYKSTI 864
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 218 bits (554), Expect = 1e-55
Identities = 647/3338 (19%), Positives = 1330/3338 (39%), Gaps = 486/3338 (14%)
Query: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS 133
+L++++++L+EE+K K K+L+ +++++K +++ + G + S E++S
Sbjct: 1101 RLEEEEKSLEEEKKEHVEKAKELQKW----VSNISKTLKDAEKAGKPPFSKQKISSEEIS 1156
Query: 134 ------------------KH-DKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQ 174
KH DK + EE E+EK LQE L+ L Q Q Q
Sbjct: 1157 TKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL--FSESLKQLQESQ 1214
Query: 175 PAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAA-QQVVREKDARFETQVRLH 233
+ ++EE ++ ++Q QE +E + + L+QT+ Q+ D E +
Sbjct: 1215 TS-GDVKVEEKIVAERQ-QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1272
Query: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
+ E LQ Q + + + ++ + L+E+ E L + L++Q+L A+ + + L+
Sbjct: 1273 KQEELQKDMQGSAQA-LAEVVKNTENFLKENGEKLSQEDKA--LIEQKLNEAKIKCEQLN 1329
Query: 294 QQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
+ +Q + E + + T E E ++++E E K NL + + ++ + E+AG
Sbjct: 1330 LKAEQSKKELDKVVTTAIKEETEKVAAVKQLE----ESKTKIENLLDWLSNVDKDSERAG 1385
Query: 354 QAQAELESRYSALEQKHKA-----EMEEKTSHILSLQKTGQ------ELQSACDALKDQN 402
++ + Q+ E +E ++L GQ L +K Q+
Sbjct: 1386 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1445
Query: 403 SKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFL--NRLPLQQH-ETASQTSFPDV 457
K++ A QSAQ + LE Q Q S E + L N L+ H ETA S
Sbjct: 1446 EKIISQHQAVIIATQSAQVL--LEKQGQYLSPEEKEKLQKNMKELKVHYETALAES---- 1499
Query: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
E +T L+K + + L S ELE L+A + ++ +T L+ Q
Sbjct: 1500 --EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1557
Query: 518 GE-ADREVSEISIVDIANKR------SSSAEESGQ--------------DVLENTFSQKH 556
E ++ + I+ R S S + G+ D + F +
Sbjct: 1558 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1617
Query: 557 KELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLE 616
+ +VL +K+ ++ + G A E K + E + P ++ LE
Sbjct: 1618 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLS--EPIAVDPKNLQRQLE 1675
Query: 617 DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676
+T ++ + +Q + E +T+E L DA L K D K+L
Sbjct: 1676 ET----------KALQGQISSQQVAVEKLKKTAEV--LLDARGSLLPAKNDIQKTLD--- 1720
Query: 677 DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE--------- 727
DI ++D + + + +L++ ++ + + LDE + N+ ++E
Sbjct: 1721 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQD-GLDEMLDWMGNVESSLKEQGQVPLNST 1779
Query: 728 -----------FKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776
+++ S+ A++E+ + + + + S + L+A++K L +EA
Sbjct: 1780 ALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM-ETTDPSTASSLQAKMKDLSARFSEA 1838
Query: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
+ + E+ + L T+ + ++ +E L +V + + + L
Sbjct: 1839 SHKHK---ETLAKMEELKTK-VELFENLSEKLQTFLETKTQALTEVDVPGKD----VTEL 1890
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQ--ALSQKELEITKMDQLLLEKKRDVETLQQ 894
+Q SE LE + + + S ++E+S S K L + K + L + + ++
Sbjct: 1891 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNL----SKKFKEMED 1946
Query: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE 954
TI+EK + VT E+ + V +K+LK + E KK + + +
Sbjct: 1947 TIKEKKEAVTSCQ-----------EQLDAFQVLVKSLKSWIK-----ETTKKVPIVQPSF 1990
Query: 955 VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014
+ L ++ ++ ++LQ ++ L E + K+ + I+ L+ V+ +
Sbjct: 1991 GAEDLGKSLEDT--------KKLQEKWSLKTPEIQ----KVNNSGISLCNLISAVTTPAK 2038
Query: 1015 ELANLKDES---KKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
+A +K E + TE + + + ++ +++ + LK I+E
Sbjct: 2039 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNT 2098
Query: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMN-----------QTLQDKTNQIDLLQAEISENQA 1120
+L ++K EE A + Q + K + ++ + Q +AE+ +N
Sbjct: 2099 KLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2158
Query: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
+Q+L T+ L++E P T + WK L E I + +E QL
Sbjct: 2159 KVQELKDKLTE--------LLEEN-----PDTPEAPRWKQMLTE-IDSKWQELNQLTIDR 2204
Query: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240
Q+ L L + Q E L++ L +++ + S + + Q +Q+QI +
Sbjct: 2205 QQKLEESSNNLTQFQTVEAQLKQWLVEKE----LMVSVLGPLSIDPNMLNTQRQQVQILL 2260
Query: 1241 RESIDGKLPSTDQQESCS----STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
+E K P +Q + S PG E+P + + V + W S + S
Sbjct: 2261 QEFATRK-PQYEQLTAAGQGILSRPG-EDPSLRGIVKEQLAAVTQK-----WDSLTGQLS 2313
Query: 1297 AL-----QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Q Q ++ L+ + + +L+ K+SS+ + T QL E K
Sbjct: 2314 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL-ETAQKMKQ 2372
Query: 1352 EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
EI+ K A+ E L ++ L+ E R+L+ L + + K E V +L
Sbjct: 2373 EIQQEKKQIKVAQALCEDLSALVKEEYLKA---ELSRQLEGILKSFKDVEQKAENHVQHL 2429
Query: 1412 SG---------QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462
Q+S A + E + I A LE K+H + K L +
Sbjct: 2430 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ-S 2488
Query: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN-----KSLQEELSLARGTIERLT 1517
M +K GE K Q K AAL + +K N K ++E + + ++E+
Sbjct: 2489 HMYEKTIAEGENLLLKTQGSEK--AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2546
Query: 1518 KSLADVESQV----SAQNK-----------EKDTVLGRLALLQEERDKLITEMDRSLLEN 1562
K VE+ QN E + + +L LQ+E D+ ++ LL N
Sbjct: 2547 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE--LLNN 2604
Query: 1563 --QSLSSSCESLKLALEGLTEDKEKLVKEI----ESLKSSKIA------ESTEWQEKHKE 1610
SL S CE K E +T++ + L++++ E L S K + E+QE KE
Sbjct: 2605 TANSLLSVCEIDK---EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2661
Query: 1611 LQKEYEIL---LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
+++ + L ++++ ++A +++ Q+K S +A K + + + A
Sbjct: 2662 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK--------SLQALKHQVDLAKRLA 2713
Query: 1668 EQEMEEMKEKMRKFAKSKQQKILELE---EENDRLRAEVHPAGDTAKECMETLLSSNASM 1724
+ + E + +K +L++E +E+ L +V D +ET L
Sbjct: 2714 QDLVVEASD-----SKGTSDVLLQVETIAQEHSTLSQQV----DEKCSFLETKLQGIGHF 2764
Query: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN 1784
+ + + ++ + S M+ +E +Q K I+ + K L A+ + N+T
Sbjct: 2765 QNTIREMFSQFAEFDDELDS-MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTC 2823
Query: 1785 ----VTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
TEE + + G + ++LS C++ + A++ V +E + L+
Sbjct: 2824 KMMLATEETSPDLVGIKRDLEALSKQ----CNKLLDRAQAREEQVEGTIKRLEEFYSKLK 2879
Query: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
+ L ++ EE + ++T+ + N + ++ K+ E++ LQ + +N L Q
Sbjct: 2880 EFSILLQKAEEHEESQGPVGMETETINQQLN--MFKVFQKE-EIEPLQGKQQDVNWLGQG 2936
Query: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
+ + ++ T + E + DD+ R LN + + +A + + +++
Sbjct: 2937 LIQSAAKSTST-QGLEHDLDDVNARWKT----LNKKVAQRAAQLQEALLHCGRFQDALES 2991
Query: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
L + + EE LV + +E K+ AQ + K LQ LL +++
Sbjct: 2992 LLSWMVDTEE----LVANQKPPSAEF------KVVKAQIQ-----EQKLLQRLLDDRKST 3036
Query: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
V+ ++++ EKI+ ++ ++ S L+ E L E R + +L
Sbjct: 3037 VEVIKRE----GEKIATTAEPADKVKILKQLSL--LDSRWEALLNKAETRNR---QLEGI 3087
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEE-----KHL 2135
V+ E L + L ++ N E + +Q + +E + + ++ KHL
Sbjct: 3088 SVVAQQFH-ETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3146
Query: 2136 KEKKNMQEKLDAL--RREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
+ ++ + L L R +K ++ + QV + ++ E L + F +
Sbjct: 3147 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3206
Query: 2194 MSSLQDDRDRVIDEAKKWERK--FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
L + + V D+ K + ++ + ++ E+R+ +++ + K + Q ++ EL
Sbjct: 3207 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLEL- 3265
Query: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA--- 2308
+ + D+ + ++ + K L + + L Q + HS+ EL
Sbjct: 3266 --LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWL 3323
Query: 2309 -KLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQN-SKFSYEQLETDLQAS 2366
K+E EL S + Q+ + + + L+ + +A + + ++ S LE +
Sbjct: 3324 DKVEVELLSYETQVLK-GEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRA 3382
Query: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
RE ++ E N + + + ++ K E I AI LR Q + + E E E+ ++
Sbjct: 3383 REGLEKMVAEDNERYRLVSDTITQKVEEIDAAI--LRSQQFDQAADAELSWITETEKKLM 3440
Query: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS------------MSSLQNDRD 2474
+ + D+T+ ++ KT E ++ K +D VKS S++ D
Sbjct: 3441 SLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLD 3500
Query: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534
+++ +Y + I E+ ++ A + N+ E L + + S ++L A +
Sbjct: 3501 KVLKNYDTI----CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPAL 3556
Query: 2535 QY------REDLNQV----------ITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
+Y +E+ Q+ I + QLLE+ + ++ KY +
Sbjct: 3557 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY-- 3614
Query: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
+ ED+++ AL E ++ + + + L R V L++ ++ ++K +
Sbjct: 3615 -SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQI 3673
Query: 2639 EE-------VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
E + +L L+ + ++R E+ K+ + K ++DKL + +
Sbjct: 3674 SENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA--VQDKLDQMV------- 3724
Query: 2692 GIMRNETETAEERVAELARDLVEMEQK-------LLMVTKENKGLTAQIQSFGRSMSSLQ 2744
I N EER A+L D++E+ +K L++ K+ + ++ G S ++
Sbjct: 3725 FIWENIHTLVEEREAKLL-DVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 3783
Query: 2745 NSRDHA---NEELDELKRKYDASLKELAQL------KEQGLLNRERDALLSETAFSMNST 2795
++ A EE+D L+ + D + ++L ++ ++ + D L S S+N
Sbjct: 3784 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKA 3842
Query: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
++ + LE+ Q + + L + ++ + ++ S S L+ + + EL++F
Sbjct: 3843 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI-EELKQF 3901
Query: 2856 RKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH 2915
KSE +Q+ E++ L Q + +++TE
Sbjct: 3902 -KSEAYQQQI------------------------------EMERLNHQAELLLKKVTE-- 3928
Query: 2916 PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975
++ QD +++ + L + ++ QH+L + Q+ A+
Sbjct: 3929 --ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG-----------QFQHALD 3975
Query: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035
+ L+H + L+ E + + ++++ + + Q+ V L
Sbjct: 3976 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL--AHQSTVEAVNKAGNDLI 4033
Query: 3036 DSL--KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVL 3093
+S +E + +++ LN + +LE+ QL +LR+ + +G++ + L
Sbjct: 4034 ESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL---DGALRQAKGFHGEIEDLQQWL 4090
Query: 3094 EKQVQELQAGPLNIDVAPGAPQEKNGVHRK--SDPEELREPQQSFSEAQQQL-------- 3143
+ L A + P +E+ VH + + E E +S + QQ+
Sbjct: 4091 TDTERHLLASK-PLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSA 4149
Query: 3144 -CNTRQEVNELRKLLE----EERDQRVAAENALSVAEE 3176
N Q++N L++ E + +++ E AL++A E
Sbjct: 4150 ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4187
Score = 204 bits (520), Expect = 9e-52
Identities = 660/3577 (18%), Positives = 1381/3577 (38%), Gaps = 604/3577 (16%)
Query: 37 ESDMEFNNTTQED-----VQERLAYAEQLVVELKDIIRQKDVQLQQKD--------EALQ 83
+S + N T+E+ VQ+ L + +++ V+L D+ + A++
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323
Query: 84 E-ERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK-HD--KSS 139
E E + KI ++++ A KLT K + +++Q +L T E L H+ +
Sbjct: 324 EFESSLKEAKISEIQMTAPLKLTYAEK-LHRLESQYAKLLNTSRNQERHLDTLHNFVSRA 382
Query: 140 TEE-----EMEIEKIKHKLQEKEELISTLQ---AQLTQA--QAEQPAQSSTEMEEFVMMK 189
T E E E E++ + E+ I+ + A+L + Q E+ +S E+ E ++++
Sbjct: 383 TNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLE 442
Query: 190 QQLQEK--EEFISTLQAQLSQT-QAEQAAQQVVREKDARFE--------TQVRLHEDELL 238
E + + +Q Q S Q Q +Q ++E A FE T + + +
Sbjct: 443 NHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAI 502
Query: 239 QLVTQADVETEMQQKLRVLQRKLEEHEE---------SLVGRAQVV-------------- 275
Q D + + + ++Q +EE EE +L+G+A+ +
Sbjct: 503 QRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKT 562
Query: 276 --------DLLQQELTAAEQRNQILSQQLQQM----------EAEHNTLRNTVETEREES 317
D Q E+T + +L+ + EA ++ TV +E+
Sbjct: 563 SIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEA 622
Query: 318 KILLEKMELEVAERKLSFHNLQEEM------HHLLEQFEQAGQAQAELESRYSALEQKHK 371
L ++E + +H M H+L+ + ++
Sbjct: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRI------------------- 663
Query: 372 AEMEEKTSHILSLQKT-GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
+ S++ S++ E Q L+ + L+D E V S I QLE ++
Sbjct: 664 -----RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVC 718
Query: 431 SKEISQFLNRLPL-QQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLL 489
+ + L +Q E+ +V N + E+ Q R ++ +
Sbjct: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
Query: 490 SSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDV-- 547
E E+LK E E+L + + N+ E + + S V + ++ V
Sbjct: 779 RITEQEKLKKELERLKDDLGTI--TNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYS 836
Query: 548 LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQ--KEMKQMEGEG 605
+ +T+ K K ++++L + A+ + + +L + A AD ++ +KQ E
Sbjct: 837 MSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE- 895
Query: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665
+++ Q F + +E ++K +A ++ +T +E L
Sbjct: 896 ---------VDEKRQVFHALEDE------LQKAKAISDEMFKTYKERDL----------- 929
Query: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN---LDEKAKEISNLN 722
D D + + Q+ ++ +++ +LE K+ + Y LD+ +++
Sbjct: 930 -DFDWHKEKADQLVERWQNVHVQIDNRLRDLE-GIGKSLKYYRDTYHPLDDWIQQVETTQ 987
Query: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVK-ELSMVTELRAQVKQLEMNLAEAERQRR 781
+ I+E N NS ++ L+S+++ + S + E + +Q +
Sbjct: 988 RKIQE---NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK------- 1037
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTL--------- 832
DYE QT + + ++ + +++ E D++ +++ TL
Sbjct: 1038 -DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
Query: 833 --IRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
++ L+ + ++ E E E E+ + + V +S+ L E ++
Sbjct: 1097 DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIS 1156
Query: 891 TLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVE 950
T ++ + E Q + +KM +EE+ L ++KTL+E NLL +E K+ Q
Sbjct: 1157 TKKEQLSEALQTIQLFLAKHGDKMT--DEERNELEKQVKTLQESYNLLF-SESLKQLQ-- 1211
Query: 951 EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL-LQRV 1009
+++ S +K ++ Q KE+LQ DLL + + +A +I + L++
Sbjct: 1212 -ESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKY 1270
Query: 1010 SRLEEELANLKDESKKEIPLSET---------ERGE--VEEDKENKEYSEKCVTSKCQEI 1058
+EEL KD L+E E GE +EDK E KC+++
Sbjct: 1271 QSKQEELQ--KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1328
Query: 1059 EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN-QIDLLQAEISE 1117
+ +Q+ E + + K+ EK+AA +Q + ++ L +N D +A
Sbjct: 1329 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1388
Query: 1118 NQAIIQKLITSNTDASDGDSVALVKET-----VVISPPCTGSSEHWKPELEEKILALEKE 1172
Q I Q + T +GD + + E ++ G + L ++ ++ +
Sbjct: 1389 KQVIEQ----NGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQ 1444
Query: 1173 KEQLQKKLQE---ALTSRKAILKK-----AQEKERHLREELKQQKDDYNRLQEQFDEQSK 1224
E++ + Q A S + +L+K + E++ L++ +K+ K Y + +++ K
Sbjct: 1445 HEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK 1504
Query: 1225 ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
++ ++L + E S + E+ + L T+ + +
Sbjct: 1505 LTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM-------TKLKRQKSF 1557
Query: 1285 CPDWPSHSEDASALQ-GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ 1343
D SH D + G V + + + KV+ +L ++ L
Sbjct: 1558 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1617
Query: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
+ N G ++ L E + L L++ + + +HL E + K + +
Sbjct: 1618 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATAS--KHLSE---PIAVDPKNLQR 1672
Query: 1404 KEEDVSYLSGQLSEKEAALTKIQ--TEII---------EQEDLIKALHT---QLEMQAKE 1449
+ E+ L GQ+S ++ A+ K++ E++ + D+ K L + E +K
Sbjct: 1673 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 1732
Query: 1450 HDERIKQLQVELCEMKQKPEEIGE--------ESRAKQQIQRKLQAALISRKEALKENKS 1501
+ER ++LQ+ L + + E ES K+Q Q L + + ++ + +N
Sbjct: 1733 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL--QDIISKNIM 1790
Query: 1502 LQEELSLARGTIERLTKSL------ADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
L+++++ + +I + + + D + S Q K KD + R + + + + +M
Sbjct: 1791 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKD-LSARFSEASHKHKETLAKM 1849
Query: 1556 DRSLLENQSLSSSCESLKLALEGLTE---DKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
+ + + + E L+ LE T+ + + K++ L ++E+ E K L+
Sbjct: 1850 EELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 1909
Query: 1613 KEYEILLQ------------SYENVSNEAERIQHVVEAVRQEK-------------QELY 1647
+ +L + E +N +++ + + + ++++K Q L
Sbjct: 1910 VLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLV 1969
Query: 1648 GKLRS--TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR--LRAEV 1703
L+S E KK Q +++ + E +K + K E+++ N+ +
Sbjct: 1970 KSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL 2029
Query: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
A T + + + S A + E E +K S+ + +S +DL +
Sbjct: 2030 ISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2089
Query: 1764 EGNVSK-QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
+ +++ L +K +++ + Q + + + PT +E+V + N
Sbjct: 2090 KDKIAELNTKLSKLQKAQEESSAMMQWLQKM---NKTATKWQQTPAPTDTEAVKTQVEQN 2146
Query: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF-------------------- 1862
K F + E+ + ++ +LK+++ L EE E
Sbjct: 2147 ----KSFEA--ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQL 2200
Query: 1863 ----SQTLENEKNTLLSQISTKDGELKMLQEEVTKM-----------NLLN---QQIQEE 1904
Q LE N L+Q T + +LK E M N+LN QQ+Q
Sbjct: 2201 TIDRQQKLEESSNN-LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2259
Query: 1905 LSRVTKLKETAEE-------------EKDDLEERLMNQLA-------ELNGSIGNYCQDV 1944
L K E+ E L + QLA L G + + C +
Sbjct: 2260 LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWI 2319
Query: 1945 TDAQIKNELLESEMKNLKKCVSELEEE------------------------KQQLVKEKT 1980
A +K+ +S +++L +S+L+ + KQ++ +EK
Sbjct: 2320 DQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKK 2379
Query: 1981 KVE----------SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
+++ + +++EYL+ Q E K +++ ++ + V+ LQ C
Sbjct: 2380 QIKVAQALCEDLSALVKEEYLKAELSRQLE----GILKSFKDVEQKAENHVQHLQSACAS 2435
Query: 2031 YQEKISALERTVKA-LEFVQTESQKDLEITK--ENLAQAVEHRKKAQAELASFKVLLDDT 2087
+ + R +A L+ + E K I+ + L ++ K L + + + T
Sbjct: 2436 -SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT 2494
Query: 2088 QSEAARVL-----ADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
+E +L ++ L+ +L + K + + KQ E E +L+++ EK LK K+ ++
Sbjct: 2495 IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE-RENKLKESLEKALKYKEQVE 2553
Query: 2143 EKLDALRREKVHLEETIGEIQVTLNKKDKE-----VQQLQENLDSTVTQLAAFTKSMSSL 2197
+ + + +LE EI+ L+ + E ++ LQ+ +D + + +SL
Sbjct: 2554 TLWPWIDKCQNNLE----EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL 2609
Query: 2198 ----QDDRDRVIDEAKKWERK---FSDAIQSK----EEEIRLKEDNCSVLKDQLRQMSIH 2246
+ D++ V DE K +K ++ + SK E + ++ V K+ RQ+
Sbjct: 2610 LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 2669
Query: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQK----------------------------- 2277
E+L I+ S Q + +K T +Q QQK
Sbjct: 2670 KEQLDIHDSL---GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGT 2726
Query: 2278 -----VCDTLQGENKELLSQLEETRHLYHSS-------QNELAKLESELKSLKDQLTDLS 2325
+T+ E+ L Q++E + QN + ++ S+ D+L ++
Sbjct: 2727 SDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMA 2786
Query: 2326 ---NSLEKCKEQKGNLEGIIRQQE---ADIQNSKFSYEQLETDLQASRELT--SRLHEEI 2377
E ++QK ++ +++ E A N+ + + + + S +L R E +
Sbjct: 2787 PVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEAL 2846
Query: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAV-- 2435
+ + K++ +EE ++ I L + + K +KE LL + EE EE++ V
Sbjct: 2847 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSK-LKEFSILLQKAEE-----HEESQGPVGM 2900
Query: 2436 --DKTNQLMETLKTIKKENI---QQKAQ---------LDSFVKSMSS--LQNDRDRIVGD 2479
+ NQ + K +KE I Q K Q + S KS S+ L++D D +
Sbjct: 2901 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNAR 2960
Query: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
++ L ++ + ++ +QEA + ++ + L S M D A +++
Sbjct: 2961 WKTLNKK----VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3016
Query: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLR--RSFNALQEEK 2597
Q+ Q+++LL+ L K + EK+ + E + ++ + + L
Sbjct: 3017 KAQI------QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRW 3070
Query: 2598 QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
+ L + E+ + ++ V A Q TL + L E+ + + + + K
Sbjct: 3071 EALLNKAETRNRQLEGIS--VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK---- 3124
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
LEE++ Q +A +ED + KHLH I ++ + ++ + ++ Q
Sbjct: 3125 LEEQI--AQHKA------LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ 3176
Query: 2718 KLLMVTKENKGLTAQI--------QSFGRSMSSLQNSRDHANEELDELK-RKYDA----- 2763
+ +E +++ + FG L N + +++L +L + Y
Sbjct: 3177 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWK 3236
Query: 2764 SLKELAQLKEQGLLNRER--DALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS 2821
EL L+E LL ++ ALL+ +T + L +KL + + ++ + + LS
Sbjct: 3237 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKL-EAIKARYKDITKLS 3295
Query: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
+ + + Q ++ + S E +++E S E + + S + + LKK
Sbjct: 3296 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3355
Query: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
K K L +++ + EL P +A +E +K A + L +
Sbjct: 3356 E-----------AKNNKALLDSLNEVSSALLELVPWRA--REGLEKMVAEDNERYRLVSD 3402
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001
++ + E + +S + + L I++ +++L L ++ E +S+Q
Sbjct: 3403 TITQKVEEIDAAILRSQ---QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ---- 3455
Query: 3002 KVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL--------RIQQLNS 3053
+Q Q+ + E D +LV + T ++ K+ +K+L I Q+NS
Sbjct: 3456 -LQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3514
Query: 3054 NFSQLLEEKNTLSIQLCDT------------------------SQSLRENQQHYGDLLNH 3089
LE +L Q +T ++LR+ Q+ + L
Sbjct: 3515 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3574
Query: 3090 CAVLEKQVQEL-QAGPLNIDVAPGAPQEKNGVHRKSD------PEELREPQQSFSEAQQQ 3142
A + + ++ + GP ++++PG + +D E++++ + EA Q
Sbjct: 3575 IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ 3634
Query: 3143 LCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
+++++ + L E +R+ ++S E+I+
Sbjct: 3635 STQFHDKIDQILESL-ERIVERLRQPPSISAEVEKIK 3670
Score = 176 bits (446), Expect = 3e-43
Identities = 620/3279 (18%), Positives = 1259/3279 (38%), Gaps = 588/3279 (17%)
Query: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER-KAADNKIKKLKLHAKAKLT 105
Q+D+Q ++V ++ +++ +L Q+D+AL E++ A K ++L L A+
Sbjct: 1278 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1337
Query: 106 SLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK-----SSTEEEMEIEKIKHK-------- 152
L+K + + + Q EE +K + S+ +++ E KHK
Sbjct: 1338 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGT 1397
Query: 153 ----------LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ-EKEEFIST 201
+ E++E+ L + + Q T E Q+++ + E+ IS
Sbjct: 1398 HFQEGDGKSAIGEEDEVNGNL------LETDVDGQVGTTQENLNQQYQKVKAQHEKIISQ 1451
Query: 202 LQAQLSQTQAEQAAQQVVREKDARF---ETQVRLHED--ELLQLVTQADVETEMQQKL-R 255
QA + TQ+ Q V+ EK ++ E + +L ++ EL A E+E + KL
Sbjct: 1452 HQAVIIATQSAQ----VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTH 1507
Query: 256 VLQRKLEEHEESLVGRAQVVDLLQQEL----TAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
LQ +LE+ + + +QEL A+ N ++++ +Q + + + +
Sbjct: 1508 SLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGD 1567
Query: 312 ------------------TEREESKILLEKMELEVAERKLS-----FHNLQEE------- 341
++R+ K+ EV +RKL F +L +
Sbjct: 1568 LRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV-QRKLDHATDRFRSLYSKCNVLGNN 1626
Query: 342 MHHLLEQFEQAGQAQAELESRYSALE---QKHKAE------------MEEKTS---HILS 383
+ L+++++ A L + A E KH +E +EE + I S
Sbjct: 1627 LKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISS 1686
Query: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL 443
Q ++L+ + L D LL KN+ IQ+ D + + +++S+ +N
Sbjct: 1687 QQVAVEKLKKTAEVLLDARGSLLPAKND--------IQKTLDDIVGRYEDLSKSVNERNE 1738
Query: 444 QQHETASQT-SFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
+ T +++ S D +E + N+ S K E+G + L+S L+++ ++N
Sbjct: 1739 KLQITLTRSLSVQDGLDEMLDWMG--NVESSLK-------EQGQVPLNSTALQDIISKNI 1789
Query: 503 KLSSQITLLEAQ-NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
L I ++ N E ++ E + D + S A+ + S KHKE
Sbjct: 1790 MLEQDIAGRQSSINAMNEKVKKFMETT--DPSTASSLQAKMKDLSARFSEASHKHKETLA 1847
Query: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
+ E+K E L +LQ + + + +++ G ++ +++++ +
Sbjct: 1848 KMEELKTKVELFENLSEKLQTFLETKT-------QALTEVDVPGKDVTELSQYMQESTSE 1900
Query: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
F L ++ KE +S H + + + L K K+ D + C
Sbjct: 1901 FLEHKKHLEVLHSLLKEISS--HGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 1958
Query: 682 HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTA 741
Q++L+ Q+L L + + + + + +L + +E+ KK + S
Sbjct: 1959 -QEQLDAF--QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPE 2015
Query: 742 LSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHS 800
+ + + +S +S VT + ++ A + + E A+ L + +
Sbjct: 2016 IQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDM 2075
Query: 801 LSIEAKSKDV------KIEVLQNELDDVQLQFSEQSTLIRSLQSQL-------------- 840
I +D+ KI L +L +Q E S +++ LQ
Sbjct: 2076 TDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2135
Query: 841 ---------QNK--ESEVLEGAERVRHISSKVEEL-------------SQALSQKELEIT 876
QNK E+E+ + +V+ + K+ EL Q L++ + +
Sbjct: 2136 TEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQ 2195
Query: 877 KMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGV---------E 927
+++QL +++ QQ +EE +T+ + L E++ + V
Sbjct: 2196 ELNQLTIDR-------QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2248
Query: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ---HEFDLL 984
+ T ++Q+ +L + +K Q E+ G+ E I KE+L ++D L
Sbjct: 2249 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2308
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS----------ETER 1034
+ R + A++ + + L ++L++L ++ + +S ET +
Sbjct: 2309 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2368
Query: 1035 GEVEEDKENKEYSEKCVTSKCQEI-----EIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
+E ++ K+ K + C+++ E YLK +S + + KD+E+K AE
Sbjct: 2369 KMKQEIQQEKKQI-KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQK--AENH 2425
Query: 1090 FQALVK------QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE 1143
Q L Q Q +D +D + E +++ I KL + L+K+
Sbjct: 2426 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLES---------LIKD 2476
Query: 1144 TVVISPPCTGSSEHWKPELEEKILALEK----EKEQLQKKLQEALTSRKAILKKAQEKER 1199
S T S ++ + E L K EK LQ +L T+ K+ +E+E
Sbjct: 2477 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2536
Query: 1200 HLREEL------KQQKDDY--------NRLQE-QFDEQSKENENIGDQLRQLQ------- 1237
L+E L K+Q + N L+E +F E EN +L+ LQ
Sbjct: 2537 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2596
Query: 1238 --IQVRESIDGKLPST---DQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPS-- 1290
+++ + L S D++ L + + TEQ H++ N+ +
Sbjct: 2597 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 2656
Query: 1291 -------------------HSEDASALQGGTSVAQIKAQLKEIEAEKVELELKV------ 1325
H S + ++ Q K ++A K +++L
Sbjct: 2657 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 2716
Query: 1326 ------SSTTSELTKKSEEVFQ----LQEQINK---------QGL--------------- 1351
S TS++ + E + Q L +Q+++ QG+
Sbjct: 2717 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 2776
Query: 1352 ----EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
E++S+ V +AE +LQ++ E+ + + LE L ++ K++ EE
Sbjct: 2777 EFDDELDSMAPVGRDAE----TLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEET 2832
Query: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE---RIKQLQVELCEM 1464
L G + EA L+K +++ D +A Q+E K +E ++K+ + L +
Sbjct: 2833 SPDLVGIKRDLEA-LSKQCNKLL---DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 2888
Query: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS-LARGTIERLTKS---- 1519
++ E G + I ++L + +KE ++ + Q++++ L +G I+ KS
Sbjct: 2889 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 2948
Query: 1520 -----LADVESQVSAQNKEKDTVLGRLALLQE--------------------ERDKLITE 1554
L DV ++ NK+ V R A LQE + ++L+
Sbjct: 2949 GLEHDLDDVNARWKTLNKK---VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3005
Query: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
E + + + + KL L+ L +D++ V+ I+ + KIA + E +K K L K+
Sbjct: 3006 QKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKR-EGEKIATTAEPADKVKIL-KQ 3062
Query: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR-------------------STEA 1655
+L +E + N+AE +E + Q+ + L T+A
Sbjct: 3063 LSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQA 3122
Query: 1656 NKKETEKQLQEAEQE--MEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKEC 1713
+K E + +A ++ + K + + + K+L E+ D +++++ + E
Sbjct: 3123 SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3182
Query: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSE-EVQDLKHQIEGNVSKQAN 1772
E S + +++ L K+ E + L D LS+ VQD + EG +Q+
Sbjct: 3183 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD--YSTEGLWKQQSE 3240
Query: 1773 LEATE-----KHDNQTNVTEEGTQSIPGETEEQ--------DSLSMSTRPTCSESVPSAK 1819
L + + N G + + T ++ +++ + S AK
Sbjct: 3241 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300
Query: 1820 SANPAVS---KDFSSHDEINNYLQQID-----------------QLKERIAGLEEEKQKN 1859
+ A+ + S+H+E+ +L +++ Q + R L++E + N
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3360
Query: 1860 KEFSQTLENEKNTLLSQIS--TKDGELKMLQEEVTKMNLLNQQIQEELSRVTK--LKETA 1915
K +L + LL + ++G KM+ E+ + L++ I +++ + L+
Sbjct: 3361 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3420
Query: 1916 EEEKDDLEERLMNQLAELNGSIGNYC--QDVTDAQIK-NELLESEMKNLKKCVSELEEEK 1972
++ D E + + + S+G+ QD T AQ++ + E+ K + +L +
Sbjct: 3421 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3480
Query: 1973 QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ 2032
+++ ++ E + K+ L+K+ K + + + QL+ R Q
Sbjct: 3481 HKIMTACSEEEKQSMKKKLDKV------------LKNYDTICQINSERYLQLE----RAQ 3524
Query: 2033 EKISALERTVKALEFVQTESQKDLE------ITKENLAQAVEHRKKAQAELASFKVLLDD 2086
++ T + L TE+Q + + E L Q E ++ + +A K +D
Sbjct: 3525 SLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDK 3584
Query: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLD 2146
++L + +Q + + Q ED+++R +E + + +K+D
Sbjct: 3585 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEA-ISQSTQFHDKID 3643
Query: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206
+ + E + + + +K +Q+ EN + +V
Sbjct: 3644 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSV---------------------- 3681
Query: 2207 EAKKWERKFSDAIQSKEEEIRL-----KEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
+ +K + + Q EE I K+ + ++D+L QM E NI L ++
Sbjct: 3682 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWE----NIHTLVEER 3737
Query: 2262 QIWESKAQTEVQLQQKV-CDTLQ-----GENKELLSQLEETR---HLYHSSQNELAKLES 2312
E+K ++L +K CD + + ++ + LE+ + Q +
Sbjct: 3738 ---EAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 3794
Query: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNS---------KFSYEQLETDL 2363
E+ L+++L + N + G + I ++ D NS K ++LE +
Sbjct: 3795 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 3854
Query: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE 2423
QA+ + L + + ++G + A I + ++I+EL+ S+ ++
Sbjct: 3855 QAAVQYQDGLQAVFDWVD------IAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQ 3908
Query: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
I +E N +A +L+ LK + +E+ + Q D ++ + +RI+ +L
Sbjct: 3909 QIEMERLNHQA-----ELL--LKKVTEESDKHTVQ-DPLMELKLIWDSLEERIINRQHKL 3960
Query: 2484 EERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV 2543
E L++ Q A E GL S + + ++ EL ++ N V
Sbjct: 3961 EGALLAL-----GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015
Query: 2544 ITIKDSQQ------KQLLEVQL-QQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
+ + + + L+E ++ L+NK L ++ + E E ++ + +
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075
Query: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTL-GLYHAQLKVKEEEVHRLSALFSSSQKRI 2655
+ EIE L+ ++ R + A + G L QL V E A + + +
Sbjct: 4076 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4135
Query: 2656 AELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD---- 2711
+ ++ L K A + + + LK++ + + NE +T E LA +
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVE----TKLNERKTKLEEALNLAMEFHNS 4191
Query: 2712 -------LVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
L + EQ L + ++ + L + H E++ EL K
Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH-REQIIELD-KTGTH 4249
Query: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
LK +Q ++ L+ ++ L+S S EK+ Q+L+ + L
Sbjct: 4250 LKYFSQKQDVVLI---KNLLISVQ------------SRWEKVVQRLVER-------GRSL 4287
Query: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
+D+ + + F +A + L W LE+ KS + + A P ++ K+
Sbjct: 4288 DDARKRAKQFHEAWSKLME-----W--LEESEKSLDSELEIANDPDKIKTQLAQHKEFQK 4340
Query: 2885 SL---------QNDRDRLLKELKNLQQQYLQINQEITEL 2914
SL N R LKE +L L+++ ++EL
Sbjct: 4341 SLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4379
Score = 156 bits (395), Expect = 3e-37
Identities = 482/2513 (19%), Positives = 1005/2513 (39%), Gaps = 376/2513 (14%)
Query: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA---QLTQAQAEQ--PA 176
L + S +S H + ++ +K+K ++Q++++ I QA L+ E+ A
Sbjct: 2343 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA 2402
Query: 177 QSSTEMEEFVMMKQQLQEK-EEFISTLQ-AQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
+ S ++E + + +++K E + LQ A S Q +Q ++ D + E Q + H
Sbjct: 2403 ELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHP 2462
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ 294
+ KL VL+ +++H++ + E T AE N +L
Sbjct: 2463 ---------------ISAKLDVLESLIKDHKD--FSKTLTAQSHMYEKTIAEGENLLLKT 2505
Query: 295 QLQQ---MEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQ 351
Q + ++ + NT++ +T ++ K K++ E E+ L + E + +++ +
Sbjct: 2506 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLK-ESLEKALKYKEQVETLWPWIDKCQN 2564
Query: 352 AGQA------QAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405
+ AE E+ + L+ K EM++ + L T L S C+ K+ +
Sbjct: 2565 NLEEIKFCLDPAEGENSIAKLKSLQK-EMDQHFGMVELLNNTANSLLSVCEIDKE----V 2619
Query: 406 LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465
+ D+N+ +Q + + +QL K + + + Q V
Sbjct: 2620 VTDENKSLIQK---VDMVTEQLHSKKFCLENMTQKF------------------KEFQEV 2658
Query: 466 TEENIASLQ--KRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523
++E+ LQ K +++ + G+ S+ L L+ + + L +A + +
Sbjct: 2659 SKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-------QALKHQVDLAKR 2711
Query: 524 VSEISIVDIANKRSSSAEESGQDVL--ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQ 581
+++ +V+ ++ + +S DVL T +Q+H LS ++ E+ +FL+ +LQ
Sbjct: 2712 LAQDLVVEASDSKGTS------DVLLQVETIAQEHSTLS------QQVDEKCSFLETKLQ 2759
Query: 582 G-KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE-- 638
G + E+ Q E + +AP+ G+D + ++ ++ A K+
Sbjct: 2760 GIGHFQNTIREMFSQFAEFDDELDSMAPV---------GRDAETLQKQKETIKAFLKKLE 2810
Query: 639 --QASTEHQSRTSEE-ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
AS ++ ++T + ++ + +L K+D L A+ QC++ L+R +++ +
Sbjct: 2811 ALMASNDNANKTCKMMLATEETSPDLVGIKRD----LEALSK--QCNK-LLDRAQAREEQ 2863
Query: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKE 755
+E + +E Y K KE S L Q EE +++ +E +Q L+ K
Sbjct: 2864 VEGTIKRLEEFYSK-----LKEFSILLQKAEEHEES----QGPVGMETETINQQLNMFKV 2914
Query: 756 LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL 815
Q KQ ++N Q + +++ L + ++ K+ + K+
Sbjct: 2915 FQKEEIEPLQGKQQDVNWLG---QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 2971
Query: 816 QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG---AERVRHISSKVEELSQALSQKE 872
+L + L + SL S + + E V + + + ++++E Q L Q+
Sbjct: 2972 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE--QKLLQRL 3029
Query: 873 LEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK 932
L+ K ++ KR+ E + T E D+ + +++ L+ +L + +T
Sbjct: 3030 LDDRKSTVEVI--KREGEKIATTAEPADK------VKILKQLSLLDSRWEALLNKAETRN 3081
Query: 933 EQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG-QISKEELQHEFDLLKKENEQR 991
QL +S + E +E NE + +++ P G Q SK E E +
Sbjct: 3082 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLE----------EQIAQ 3131
Query: 992 KRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV---EEDKENKEYSE 1048
+ L+ +IN + L + + + L L K++ S+ + +V E +++ SE
Sbjct: 3132 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3191
Query: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA----EEQFQALVKQMNQTLQDK 1104
+ C + E EVEL + ++ +KL+ + + L KQ ++ +
Sbjct: 3192 LLQQALCNA------KIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL---R 3242
Query: 1105 TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP----CTGSSEHWKP 1160
Q D+L + + +QA++ L + GD V ++++ + T S
Sbjct: 3243 VLQEDILLRKQNVDQALLNGL--ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300
Query: 1161 ELEEKILA---LEKEKEQL----QKKLQEALTSRKAILKKAQEKERHLR-EELKQQKDDY 1212
LE+ + L E+L K E L+ +LK + + +R +ELK++ +
Sbjct: 3301 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3360
Query: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE----SCSSTPGLEEPLF 1268
L + +E S L + + RE ++ K+ + D + S + T +EE
Sbjct: 3361 KALLDSLNEVSSA------LLELVPWRAREGLE-KMVAEDNERYRLVSDTITQKVEEIDA 3413
Query: 1269 KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ--IKAQLKEIEAEKVELELKVS 1326
++ L W + +E G + Q AQL+ + +E+ L+
Sbjct: 3414 AILRSQQFDQAADAEL--SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI-LRHK 3470
Query: 1327 STTSELTKKSEEVFQLQEQINKQGLEIES---LKTVSHEAEVHAESLQQKLESSQLQIAG 1383
+L K ++ + KQ ++ + LK ++++E Q + L
Sbjct: 3471 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQF 3530
Query: 1384 LEHLRELQPKLDELQKLISK-------------KEEDVSYLSGQLSEKEAALTK------ 1424
E EL P L E Q +IS+ ++E+ L ++E + + K
Sbjct: 3531 WETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3590
Query: 1425 ------------IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ---LQVELCEMKQKPE 1469
IQ + + + L + ++ +A DE I Q ++ ++ + E
Sbjct: 3591 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 3650
Query: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
I E R I +++ KE + ENK++ ++ + E L + ++ ++
Sbjct: 3651 RIVERLRQPPSISAEVEKI----KEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 3706
Query: 1530 QNKEKDTV-----LGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
+K+ L ++ + E L+ E + LL+ L+ ++L +D +
Sbjct: 3707 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 3766
Query: 1585 KLVKEIES--LKSSKIAESTEWQEKHKE----LQKEYEILLQ-SYENVSNEAERIQHVVE 1637
++++E + S + + E E +E LQ+E +I++ E ++ E + +V+
Sbjct: 3767 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 3826
Query: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
E + L K+ +L+EA Q + ++ + Q + + +
Sbjct: 3827 KSIDELNSAWDSLNKAW---KDRIDKLEEAMQAAVQYQDGL--------QAVFDWVDIAG 3875
Query: 1698 RLRAEVHPAG---DTAKECMETL--LSSNASMKE-ELERVKMEYETLSKKFQS------- 1744
A + P G +T K+ +E L S A ++ E+ER+ + E L KK
Sbjct: 3876 GKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTV 3935
Query: 1745 ---LMSEK---DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPG 1795
LM K DSL E + + +H++EG + + EG Q G
Sbjct: 3936 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 3995
Query: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSK------DFSSHDEINNYLQQIDQLKERI 1849
+ + ++ V + +S AV+K + S+ +E +N +++ L +R
Sbjct: 3996 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4055
Query: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK----------MNLLNQ 1899
+ E+ ++ K+ + + L Q GE++ LQ+ +T + L +
Sbjct: 4056 QNVLEKTEQRKQ-------QLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4108
Query: 1900 QIQEELS---RVTKLKETAEEEKDDLEERLMNQLAELNGSIG-NYCQDVTDAQIKNELLE 1955
+E+L+ V E EE L ++ LA S N QD+ + + K E +E
Sbjct: 4109 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4168
Query: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+++ K ++LEE ++ ++ +++ + A++ S + + +
Sbjct: 4169 TKLNERK---TKLEEALNLAMEFHNSLQ-----DFINWLTQAEQTLNVASRPSLILDTVL 4220
Query: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR-KKAQ 2074
+ E K + ++E+I L++T L++ SQK + +NL +V+ R +K
Sbjct: 4221 FQIDEHKVFANEVNSHREQIIELDKTGTHLKYF---SQKQDVVLIKNLLISVQSRWEKVV 4277
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
L LDD + A + KL + L+ +++S+ S+++ ++ + + + A+ K
Sbjct: 4278 QRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE 4337
Query: 2135 LKEKKNMQEKL-DALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKS 2193
++ + + D R L+E L K D + +L++ D+ +
Sbjct: 4338 FQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSV----- 4391
Query: 2194 MSSLQDDRDRVIDEAKKWERKFSDAIQSKEE-----EIRLKE---------------DNC 2233
+R ++EA + +F+DA+Q+ + E +L E DN
Sbjct: 4392 ------ERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4445
Query: 2234 SVLKDQLRQMSIHMEELKINISRL---EHDKQIWESKAQTEVQLQ-QKVCD---TLQGEN 2286
+ +L + + ++ LK + L D W E+ + + VC + Q
Sbjct: 4446 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4505
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
+ L Q EE + H+ LA+ E L+ L D ++L +Q + ++
Sbjct: 4506 EAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKR 4564
Query: 2347 ADIQNS--------KFSYEQLETDLQASRELTSRLHEEI----NMKEQKIISLLSG---K 2391
A++ + + T ++ + EE+ +Q++ S L+G K
Sbjct: 4565 AELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4624
Query: 2392 EEAIQVAIAELR------QQHDKEI--KELENLLSQEEEENIVLEEENKKAVD 2436
+E ++ +A L+ DKE+ +E+E + + E +EE +K D
Sbjct: 4625 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPD 4677
Score = 129 bits (324), Expect = 5e-29
Identities = 476/2605 (18%), Positives = 1047/2605 (40%), Gaps = 386/2605 (14%)
Query: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQE------RLAYAEQLVVELKDIIRQK--D 72
D D + + L H ++ + T Q+ QE ++ A+ L +L +++++
Sbjct: 2342 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2401
Query: 73 VQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132
+L ++ E + + K + K + H ++ S +++ ++M L T+ EEQ
Sbjct: 2402 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF-QQMSRDFQAWLDTK--KEEQN 2458
Query: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL 192
H S+ +++ ++ +++ ++ TL AQ M ++ +
Sbjct: 2459 KSHPISA-----KLDVLESLIKDHKDFSKTLTAQSH------------------MYEKTI 2495
Query: 193 QEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQ 252
E E + L+ Q S+ A Q ++ F QV+ E++L + + +A + ++
Sbjct: 2496 AEGENLL--LKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA---LKYKE 2550
Query: 253 KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN--QILSQQLQQMEAEHNTLRNTV 310
++ L +++ + +L +D + E + A+ ++ + + Q +E +NT + +
Sbjct: 2551 QVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLL 2610
Query: 311 -------ETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG-QAQAELESR 362
E +E+K L++K+++ V E+ S E M ++F++ +++ +L+
Sbjct: 2611 SVCEIDKEVVTDENKSLIQKVDM-VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 2669
Query: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQS------ 416
L+ + ++ L++ +T Q+ A D +L QD +A S
Sbjct: 2670 KEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV 2729
Query: 417 ---AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE-ENIAS 472
+TI Q L Q+ E FL Q Q + +++++ + E +++A
Sbjct: 2730 LLQVETIAQEHSTLSQQVDEKCSFLETK--LQGIGHFQNTIREMFSQFAEFDDELDSMAP 2787
Query: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGE----ADREVSEIS 528
+ + L+ +K + +LE L A N+ + ++ A T R++ +S
Sbjct: 2788 VGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 2847
Query: 529 -----IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
++D A R E + + + E F K KE S+LL + +E +E + ++ +
Sbjct: 2848 KQCNKLLDRAQAREEQVEGTIKRLEE--FYSKLKEFSILLQKAEEHEESQGPVGMETETI 2905
Query: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
+ +V ++E++ ++G+ + + GQ + +S +E +
Sbjct: 2906 NQQLNMFKVFQKEEIEPLQGK-------QQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVN 2958
Query: 644 HQSRTSEE------ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD------ELERLKS 691
+ +T + L +A + + + LS + D + + E + +K+
Sbjct: 2959 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA 3018
Query: 692 QILELEL------NFHKAQEIYEKNLDEKA------------KEISNLNQLIEEFKKNAD 733
QI E +L + E+ ++ ++ A K++S L+ E A+
Sbjct: 3019 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3078
Query: 734 NNSSAFTALSEERDQLLSQVKELS-MVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN 792
+ +S Q ++ L+ +T + ++ E +A + + + D+
Sbjct: 3079 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3138
Query: 793 LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE 852
++ H + + +K+ + + D VQ + +Q + ++ SE+L+ A
Sbjct: 3139 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR-SELLQQAL 3197
Query: 853 RVRHISSKVE-ELSQALSQKELEITKMD------QLLLEKKRDVETLQQTIEEKDQQVTE 905
I + E EL L++ +++K+ + L +++ ++ LQ+ I + Q V +
Sbjct: 3198 CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ 3257
Query: 906 ISFSMTEKMVQLN-EEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
+ E + Q +E + +++ +K + +++ + +E+ +++ L ++
Sbjct: 3258 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3317
Query: 965 EMSP-AGQISKEELQHEFDLLKKEN----EQRKRKLQAALINRKELLQRVSRLEEELANL 1019
E+ ++ E L +E +LK E + R ++L+ N K LL ++ + L L
Sbjct: 3318 ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLEL 3377
Query: 1020 KDESKKEIPLSETERGE--VEEDKENKEYSEKCVTSKCQEIEIYL---KQTISEKEVELQ 1074
+P E E V ED E +T K +EI+ + +Q + EL
Sbjct: 3378 -------VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELS 3430
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQ-DKTNQIDLLQAEISENQAIIQKLITSN---- 1129
I + E+KL + + Q + LQ KT +++L+ ++ II L+ S
Sbjct: 3431 WIT-ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR-----HKDIIDDLVKSGHKIM 3484
Query: 1130 TDASDGDSVALVKETVVI----SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
T S+ + ++ K+ + C +SE + E+ +L + + ++L LT
Sbjct: 3485 TACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL--ERAQSLVNQFWETYEELWPWLT 3542
Query: 1186 SRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI---GDQLRQLQIQVRE 1242
++I+ + E L+QQ++++ +L+E E + + G QL +L
Sbjct: 3543 ETQSIISQLPAPALEY-ETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF 3601
Query: 1243 SIDGKLPSTD------QQESCSSTPGLEEPLFKATEQHHT-QPVLESNLCPDWPSHSEDA 1295
SI K + D +++ L+E + ++T+ H +LES
Sbjct: 3602 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES------------- 3648
Query: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ---EQINKQGLE 1352
+ +I +L++ + E+E K+ SE S ++ +LQ E + ++G E
Sbjct: 3649 --------LERIVERLRQPPSISAEVE-KIKEQISENKNVSVDMEKLQPLYETLKQRGEE 3699
Query: 1353 IESLKTVSHEAEVHAESLQQKLESS-----------QLQIAGLEHLRELQPKL--DELQK 1399
+ + ++ + ++ A+++Q KL+ + + A L + EL K D +
Sbjct: 3700 MIA-RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSL 3758
Query: 1400 LISKKE--------EDVSYLSGQLSEKEAALTKIQTEII---EQEDLIKALHTQLEMQAK 1448
+++ K+ ED + +++ A I+ EI E+ D++ L ++L
Sbjct: 3759 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG 3818
Query: 1449 EHDERIKQLQVELCEM---------KQKPEEIGEESRAKQQIQRKLQAA----------- 1488
E D+ I + ++ K + +++ E +A Q Q LQA
Sbjct: 3819 EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 3878
Query: 1489 ---------LISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV-- 1537
L + K+ ++E K + E + +ERL A++ + + +K TV
Sbjct: 3879 ASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEESDKHTVQD 3937
Query: 1538 -LGRLALLQEERDKLIT----EMDRSLLENQSLSSSCESLKLAL---EGLTEDKEKL--- 1586
L L L+ + ++ I +++ +LL + + L L EGL +++ +
Sbjct: 3938 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 3997
Query: 1587 --VKEIESLK---------------------SSKIAESTEWQEKHKELQKEYEILLQSYE 1623
EIE K + + ES+ +E LQ + E+L Q ++
Sbjct: 3998 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEA-SNLQNKLEVLNQRWQ 4056
Query: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
NV + E+ + ++ ++ + +G++ + +TE+ L A + + + E ++
Sbjct: 4057 NVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLL-ASKPLGGLPETAKEQLN 4115
Query: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
+ E + + ++ + C + S+ ++ +++ +K ++E++ K
Sbjct: 4116 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPK---SAETNIDQDINNLKEKWESVETK-- 4170
Query: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQAN-LEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
++E+ + EE +L + ++ N L E+ N + ++ + +E
Sbjct: 4171 --LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4228
Query: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEI-----------NNYLQQIDQLKERIAG 1851
+ + + K+ K FS ++ + + + + +L ER
Sbjct: 4229 FANEVNSHREQIIELDKTGTHL--KYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4286
Query: 1852 LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ--EEVTKMNLLNQQIQEELSRVT 1909
L++ +++ K+F + L + D EL++ +++ +++ Q+ L
Sbjct: 4287 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4346
Query: 1910 KLKETAEEEKDDLEE---------RLMNQLAELNGSIGNYCQDVTDAQIKNE---LLESE 1957
+ +T L+E +L + L+EL C + Q K E L +
Sbjct: 4347 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4406
Query: 1958 MKN-LKKCVSELEEEKQQLVKEK-TKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
+ L+ + L + QL +++ + ++ ++ + QKE G ++ + + LK
Sbjct: 4407 FTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS---VQALK 4463
Query: 2016 EKQQEVKQLQKDCIRY----QEKISALERTVKALEF-VQTESQKDLEITKE--NLAQA-V 2067
+E+ + +D + +++S TV AL QT + L +E ++ A +
Sbjct: 4464 RSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL 4523
Query: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLK-LKKELQSNKESVKSQMKQKDEDL--- 2123
E +A+ L VL DD +A R L D K K+L+ + + D L
Sbjct: 4524 EWLAEAEQTLRFHGVLPDD--EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAIC 4581
Query: 2124 ---------------ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ---VT 2165
R E+ + ++ + L L ++ LE + +Q T
Sbjct: 4582 HPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETT 4641
Query: 2166 LNKKDKEV-QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSD--AIQS- 2221
L KDKEV Q E + + + + F + M+ Q D D+V K ++R+ +D ++QS
Sbjct: 4642 LTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV---TKTYKRRAADPSSLQSH 4698
Query: 2222 ----KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK 2277
+ K S L Q I + ++N+ + +Q+W + +L
Sbjct: 4699 IPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL-LVSKWQQVWLLALERRRKL--- 4754
Query: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE-LKSLKDQLTDLSNSLEKCKEQKG 2336
+ L +LEE R + + K + K ++ D ++K ++ K
Sbjct: 4755 ---------NDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGK- 4804
Query: 2337 NLEGIIRQQEAD-IQNSKFSYEQLE 2360
I RQ+ D I +SKF +LE
Sbjct: 4805 ----ITRQEFIDGILSSKFPTSRLE 4825
Score = 68.9 bits (167), Expect = 8e-11
Identities = 263/1488 (17%), Positives = 567/1488 (38%), Gaps = 262/1488 (17%)
Query: 1900 QIQEELSRVTKLKETAEEEKDDLE--ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESE 1957
QI++ L + + L + EE+ +++ + L+N + E+ + D T+ +ES
Sbjct: 257 QIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL-----DRTEWGSDLPSVESH 311
Query: 1958 M---KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
+ KN+ + + E E ++ + ++ + ++ Y EK+ + S +L
Sbjct: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE------SQYAKLLNTS 365
Query: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
+ +++ + L R ++ L E + E D N+A+ ++ +
Sbjct: 366 RNQERHLDTLHNFVSRATNELIWLN------EKEEEEVAYDWSERNTNIARKKDYHAELM 419
Query: 2075 AELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
EL + + Q A ++L +N + +++ + ++++Q +L Q E+H
Sbjct: 420 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQW-----SWILQLCQCVEQH 474
Query: 2135 LKEK-------KNMQEKLDALRREKVHLEETIG-EIQVTLNKKDKEVQQLQENLD----- 2181
+KE + +E D LR K ++ + +++K + VQ+ E +
Sbjct: 475 IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY 534
Query: 2182 -STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL-KEDNCSVLKDQ 2239
ST+ L K++ L + R D K ++ EI + K+D C + +
Sbjct: 535 KSTIANLMGKAKTIIQL---KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 591
Query: 2240 LR------------------------------QMSIHMEELKINISRLEHDKQI------ 2263
R ++ +E+ N+ L H+ I
Sbjct: 592 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVV 651
Query: 2264 -WESKAQTEVQLQ----QKVCDTLQGENKELLSQ--------LEETRHLYHSSQNELAKL 2310
W +++ + L GE++++LS LE+++ S +++ +L
Sbjct: 652 SWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 711
Query: 2311 ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE--------QLETD 2362
E E+ K +L S E+ +++ E + ++++N + E Q+ T
Sbjct: 712 EKEVNVCKQYYQELLKSAEREEQE----ESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 767
Query: 2363 LQAS--RELTSRLHEEINMKEQ-----KIISLLSGK------EEAIQVAIAELRQQHDKE 2409
L+ E R+ E+ +K++ + ++ K + A ++ LR + +
Sbjct: 768 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 827
Query: 2410 IKELENLLSQ-----EEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
++ + + S ++ + + L +N +A + +L ET ++ I K +++ +
Sbjct: 828 LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS 887
Query: 2465 SMSSLQNDRD----------------RIVGD--YQQLEERHLSIILEK---DQLI---QE 2500
++ +++ D + + D ++ +ER L K DQL+ Q
Sbjct: 888 TLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQN 947
Query: 2501 AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560
+ + ++ G+ + LD + IQ E + I + + L QL
Sbjct: 948 VHVQIDNRLRDLEGIGKSLKYYRDTYHPLD-DWIQQVETTQRKIQENQPENSKTLATQLN 1006
Query: 2561 QNK----ELENKYAKLEEKLKESEEANEDLR------RSFNALQEEKQDLSKEIESLKVS 2610
Q K E+E K +K++E K +E+ + ++ ++ A+ + +Q + ++ S
Sbjct: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066
Query: 2611 ISQLTRQVTALQEEGT--LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
+ ++ L+ T + L +K + + RL +K + E ++E V KE
Sbjct: 1067 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL----EEEEKSLEEEKKEHVEKAKE 1122
Query: 2669 AAKKVGEIEDKLK---KELKHLHHDAGIMRNETETAEERVAELAR--DLVEMEQKLLMVT 2723
K V I LK K K I E T +E+++E + L + M
Sbjct: 1123 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD 1182
Query: 2724 KENKGLTAQIQS--------FGRSMSSLQNSRDHANEELD-----ELKRKYDASLKELAQ 2770
+E L Q+++ F S+ LQ S+ + +++ E +++Y L+ +
Sbjct: 1183 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICD 1242
Query: 2771 L---KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
L E L+ + ++ + + + + + + E + + + L+++
Sbjct: 1243 LLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1302
Query: 2828 YNQVQSFSKAM-------ASLQNERDHLWNELEKFR---------KSEEGKQRSAAQPST 2871
++ KA+ A ++ E+ +L E K K E K + Q
Sbjct: 1303 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1362
Query: 2872 SPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE------ITELHPLKAQLQEYQ 2925
S ++++L +S++ D +R + K + +Q QE I E + L E
Sbjct: 1363 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-T 1421
Query: 2926 DKTKAFQIMQEELRQ--ENLSWQHE----LHQLRM--------------------EKSSW 2959
D QE L Q + + QHE HQ + EK
Sbjct: 1422 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1481
Query: 2960 EIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASP 3017
+ + + +K Y A+++ ++++ +L EL + + +Q Q A
Sbjct: 1482 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1541
Query: 3018 DGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQ---LCDTSQ 3074
D L+ + + ++ D + H+ +LR ++ N ++LE + S + DTS
Sbjct: 1542 DDINGLMTKLKRQKSFSEDVIS--HKGDLRYITISGN--RVLEAAKSCSKRDGGKVDTSA 1597
Query: 3075 SLRENQQ-------HYGDLLNHCAVLEKQVQEL----------QAGPL-NIDVAPGAPQE 3116
+ RE Q+ + L + C VL +++L G L + +
Sbjct: 1598 THREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASK 1657
Query: 3117 KNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR 3164
DP+ L+ + Q Q+ + + V +L+K E D R
Sbjct: 1658 HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDAR 1705
Score = 33.9 bits (76), Expect = 2.7
Identities = 56/307 (18%), Positives = 134/307 (43%), Gaps = 24/307 (7%)
Query: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
N+ +L+Q R+ L + + + ++ E+ ++ ++L N +++ +L +E ++
Sbjct: 248 NSLQTLKLMQIRKPLLKSSLLDQNLTEE--EINMKFVQDLLNWVDEMQVQLDRTEWGSD- 304
Query: 2586 LRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
S + E +++ + IE + S+ + +++ +Q L L +A E++HRL
Sbjct: 305 -LPSVESHLENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYA------EKLHRLE 355
Query: 2646 ALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV 2705
+ ++ E L + ++ E+ +KE + + +D ++
Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 2706 AELARDLVEMEQKLLMVTK-------ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELK 2758
AEL R+L + E+ + V + EN I+++ +M + + + +++
Sbjct: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
Query: 2759 RKYDASLKELAQLKE-QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQL 2817
++ A + KE L +DA+ + + +S S+ LE L Q+ + + E+L
Sbjct: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS----SIHKLEDLVQESMEEKEEL 531
Query: 2818 LHLSSQL 2824
L S +
Sbjct: 532 LQYKSTI 538
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 216 bits (549), Expect = 4e-55
Identities = 330/1693 (19%), Positives = 727/1693 (42%), Gaps = 237/1693 (13%)
Query: 1508 LARGTIERLTKSLAD-VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL- 1565
L R + +L KS+ + +E ++ Q E D + GR + E ++ E+++ L +Q
Sbjct: 9 LERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERL 68
Query: 1566 ---SSSCESLKLALEGLTEDKEKLV---KEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619
+ C+SL+L LE L + L KE+E + IA +++ +EL+ E L+
Sbjct: 69 VNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLI 128
Query: 1620 QSYENVSNEAERIQHVVEAVRQEKQEL----------YGKLRSTEANKKETEKQLQEAEQ 1669
++ E +S E E + V+ + ++ +E +L++++ + K EK+L++ ++
Sbjct: 129 RTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKE 188
Query: 1670 -----------EMEEMKEKMRKFAKSKQQKILELE-------EENDRLRAEVH---PAGD 1708
E++ +++ + K +ILEL+ EE RL +++ + +
Sbjct: 189 LLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNE 248
Query: 1709 TAKECMETLLSS-------NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD--- 1758
++ +E LL+ ASM+E+ + LS ++S + ++ S E+
Sbjct: 249 HLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVE 308
Query: 1759 -----LKHQIEGNVSKQANL-EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR---- 1808
LK E N + Q +L E + D E + E E + L +T+
Sbjct: 309 ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGA 368
Query: 1809 ----PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQ 1864
+ P+A + V + N Y++ DQL EK +NK ++
Sbjct: 369 ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLL-------EKLENKRINK 421
Query: 1865 TLENEKNTLLSQISTKDGELKMLQEEVTKMNL----LNQQIQEELSRVTKLKETAEE--- 1917
L+ ++ ++ K LK +EE + L+ ++++ + + +L+E ++
Sbjct: 422 YLDE----IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANK 477
Query: 1918 -----EKD---------DLEERLMNQLAELNGSIGNYC---QDVTDAQIKN--ELLESEM 1958
E+D DL +++ L EL + GN+ ++V+ A I + E++ +
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHL 537
Query: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK--SHAKELQELLKE 2016
+ + + EL+++ Q+L+ ++ +E E E K S EL++L K
Sbjct: 538 VSYRN-IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKS 596
Query: 2017 KQQEVKQL-----QKDCIRY---QEKISALERTVKALEFVQTESQKDLEITKENLAQ--- 2065
+Q +++ + Q+D R Q A+ +L+ V S T + ++
Sbjct: 597 RQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAP 656
Query: 2066 --AVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2121
+E + +A+A L + + ++ + E A +N K++ E + + ++ ++
Sbjct: 657 VPVIESTEAIEAKAALKQLQEIFENYKKEKA----ENEKIQNEQLEKLQEQVTDLRSQNT 712
Query: 2122 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181
+ +L+ A +++ + +Q+ ++ RRE L E ++ T K+++ + + ++L
Sbjct: 713 KISTQLDFASKRY----EMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
Query: 2182 STVTQLAAFTKSMSSLQDDRDRV-IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
+LA +L+ +++ + + E + +++ S + + + + L N ++ L
Sbjct: 769 GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLT--NLQTIQGIL 826
Query: 2241 RQMSIHMEE-LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE----- 2294
+ ++ L I +LEH+ + K + EV+ + + L + + QL+
Sbjct: 827 ERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNL 886
Query: 2295 --ETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI------IRQQE 2346
T+ L ++Q E+A L+ L +++ Q+ S S K Q N E + +RQ E
Sbjct: 887 HLNTKELLKNAQKEIATLKQHLSNMEVQVASQS-SQRTGKGQPSNKEDVDDLVSQLRQTE 945
Query: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406
+ + K + ++++ + + + L E +N KE+++ + E AE + Q
Sbjct: 946 EQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAEFQTQL 1004
Query: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
+K++ E+E +E++E L+++ ++A++ Q + LK ++Q + Q ++ ++
Sbjct: 1005 EKKLMEVE----KEKQE---LQDDKRRAIESMEQQLSELKKTLS-SVQNEVQ-EALQRAS 1055
Query: 2467 SSLQNDRD---------RIVGDYQQLEERHLSIILEKDQLIQEAAAENNK---------- 2507
++L N++ +I + Q ER L + + +Q A + +K
Sbjct: 1056 TALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
Query: 2508 ----------------------LKEEIRGLRSHMDDLNSENAKLDAELIQYRED------ 2539
LK+E+ +DL +N L ++ + +
Sbjct: 1116 TTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK 1175
Query: 2540 ------LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
LN ++ + Q+Q+LE+ +E E + E ES + + L
Sbjct: 1176 EGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLEREL 1235
Query: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
QE + L+ E E ++V+ + + +++ T+ + K+ EE RL Q
Sbjct: 1236 QELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQA 1295
Query: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM--RNETETAEER---VAEL 2708
++ +LE +++ +Q EA ++ E L+ E K L D RN+ ++++ E
Sbjct: 1296 KVRKLELDILPLQ-EANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEY 1354
Query: 2709 ARDLVEME---QKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASL 2765
+ L E E +++ +T+E L A+I S+++ QN E+L++++ + +
Sbjct: 1355 RKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQ 1414
Query: 2766 KELAQLKEQGLLNRERDALLSETAFSMNS-TEENSLSHLEKLN-QQLLSKDEQLLHLSSQ 2823
K+L DA + + + + T+ + K ++L ++ ++++ S+Q
Sbjct: 1415 KDL-------------DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ 1461
Query: 2824 LEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883
+ + + M L+ + + + E Q++ ++ T E ++L++
Sbjct: 1462 SSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKET---EARNLQEQT 1518
Query: 2884 SSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQI--MQEELRQE 2941
LQ++ RL ++L++ Q Q+ Q+ITE K + K+K + ++++L +E
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE-KTRKAIVAAKSKIAHLAGVKDQLTKE 1577
Query: 2942 NLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPL 3001
N + L +K ++ +K QY IS +++L Q E R +
Sbjct: 1578 NEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNK 1637
Query: 3002 KVQYQRQASPETS 3014
+ QRQ + +T+
Sbjct: 1638 VPEQQRQITLKTT 1650
Score = 204 bits (519), Expect = 1e-51
Identities = 338/1783 (18%), Positives = 749/1783 (42%), Gaps = 211/1783 (11%)
Query: 864 LSQALSQKELEI------TKMDQLLLEKKRDVETLQQTIE----EKDQQVTEISFSMT-- 911
L Q L + EL K+++ L +++ +++ L+ E E +QQ EI ++
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
Query: 912 -EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAG 970
E++V E SL +E++ L QL L+ E+ K+ ++ +D ++
Sbjct: 65 QERLVNETRECQSLRLELEKLNNQLKALT--EKNKELEIAQDRNIA-------------- 108
Query: 971 QISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLS 1030
+Q +F K+E E KR L + + L Q + L E++ L ++ K+ S
Sbjct: 109 ------IQSQFTRTKEELEAEKRDL---IRTNERLSQELEYLTEDVKRLNEKLKE----S 155
Query: 1031 ETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090
T +GE++ + + S+ + + ++ E+E EL H +
Sbjct: 156 NTTKGELQLKLDELQASD---------VSVKYREKRLEQEKELLHSQNTW---------- 196
Query: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
+N L+ KT+++ L E N+ + K N KE V
Sbjct: 197 ------LNTELKTKTDELLALGRE-KGNEILELKCNLENK-----------KEEV----- 233
Query: 1151 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210
LEE++ L+ E LQK +++ LT LK+A+E++ + E+ + +
Sbjct: 234 ---------SRLEEQMNGLKTSNEHLQKHVEDLLTK----LKEAKEQQASMEEKFHNELN 280
Query: 1211 DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKA 1270
+ +L + + ++E ++L + ++ + + +E+ + +++ L +
Sbjct: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLL---------KEAGEANKAIQDHLLEV 331
Query: 1271 TEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEK--VELELKVSST 1328
+ E+A+ L T +E+ A K+
Sbjct: 332 EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
Query: 1329 TSELTKKSEEVFQLQEQINKQGLEIES----LKTVSHEAEVHAESLQQKLESSQLQIAGL 1384
+LT+ + Q+Q+ + LE + L + E E A L+++ E +
Sbjct: 392 GMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE---RAQ 448
Query: 1385 EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLE 1444
+ + L KL++ K I + +ED + Q S E +++ ++ + I+ L +LE
Sbjct: 449 KAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELE 508
Query: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEES---RAKQQIQRKLQAALISRKEALKENKS 1501
H I+ +V ++ E I + R +++Q++ Q L++ +E L E +
Sbjct: 509 EARGNHV--IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRE-LGETRE 565
Query: 1502 LQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLE 1561
+EE I L L +++ K + + + + +RD M R LL
Sbjct: 566 -REEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRD-----MYRILLS 619
Query: 1562 NQS------LSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEY 1615
+ +SS + + LA T + + + + + ESTE E L++
Sbjct: 620 QTTGVAIPLHASSLDDVSLAS---TPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
Query: 1616 EILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK 1675
EI ++Y+ E E+IQ+ ++ ++L ++ + + QL A + E ++
Sbjct: 677 EIF-ENYKKEKAENEKIQN------EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQ 729
Query: 1676 EKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA----------SMK 1725
+ + + +++I L E N +L A + L +N ++K
Sbjct: 730 DNVEGY----RREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLK 785
Query: 1726 EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV 1785
+E E +K+ LS++ +SL++E+ + + +L+ I+G + +++ E ++ +Q
Sbjct: 786 KEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ-TIQG-ILERSETETKQRLSSQIEK 843
Query: 1786 TEEGTQSIPGETE-EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQ 1844
E + + E E + TR + + + + + + ++ + + N ++I
Sbjct: 844 LEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIAT 903
Query: 1845 LKERIAGLE-----EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQ 1899
LK+ ++ +E + Q+ + + + + + L+SQ+ + ++ L+E ++
Sbjct: 904 LKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKE---RLKTSTS 960
Query: 1900 QIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK 1959
+++ + VT L+E+ +EK EE N L S + T + K +E E +
Sbjct: 961 NVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES----AEFQTQLEKKLMEVEKEKQ 1016
Query: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAK-ELQELLKEKQ 2018
L+ E +Q + E K S ++ E E +Q A N+ A+ + QE K
Sbjct: 1017 ELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAV 1076
Query: 2019 QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE------HRKK 2072
+ + +++ + + + AL+ + + + + Q E T++ +Q +E R++
Sbjct: 1077 EAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERER 1136
Query: 2073 AQAELASFKVLLDDTQSEAARVLADNLKL--KKELQSNKESVKSQM--------KQKDED 2122
+ S V + + R+L D ++ K + S KE V+ + K +++
Sbjct: 1137 MLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQI 1196
Query: 2123 LERRLEQAEEKHLKEKKNMQEKLDALR-REKVHL-EETIGEIQVTLNKKDKEVQQLQENL 2180
LE EK + E + ++++LR R++V L E + E+Q +LN + ++VQ + +
Sbjct: 1197 LEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTM 1256
Query: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
+ +L T++M+ + + + +E ++ E+ +Q + ++R E + L++
Sbjct: 1257 -AQHEELMKKTETMNVVMETNKMLREEKERLEQD----LQQMQAKVRKLELDILPLQEAN 1311
Query: 2241 RQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLY 2300
++S L+ LE D + W+++ Q V QQK DT E ++LLS+ E
Sbjct: 1312 AELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS-QQKDPDT--EEYRKLLSEKEVHTKRI 1368
Query: 2301 HSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLE 2360
E+ +L++E+ LT+ N ++ KE + + D+ ++
Sbjct: 1369 QQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKV 1428
Query: 2361 TDLQASRELTSRL---HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD--KEIKELEN 2415
+ +++ R +EE+ ++ K++ E + + ++QH +E++EL+
Sbjct: 1429 KTITQVKKIGRRYKTQYEELKAQQDKVM-------ETSAQSSGDHQEQHVSVQEMQELKE 1481
Query: 2416 LLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
L+Q E ++ LE + + ++ + ++++ +Q +++L + + ++
Sbjct: 1482 TLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQ 1541
Query: 2476 IVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ 2535
+ + EE+ I+ I A ++L +E L+ L+ + +LD +
Sbjct: 1542 LRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITA 1601
Query: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
+ I+ + + ++ E L+Q E + K+ E+ ++
Sbjct: 1602 LKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQ 1644
Score = 201 bits (510), Expect = 1e-50
Identities = 341/1691 (20%), Positives = 706/1691 (41%), Gaps = 302/1691 (17%)
Query: 1650 LRSTEANK------KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
L TE NK + EK L + + E++ +K + KF +Q+ E+E+ RL
Sbjct: 9 LERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEK---RLSHSQ 65
Query: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
+ +EC S++ ELE++ + + L++K + L E QD I
Sbjct: 66 ERLVNETRECQ--------SLRLELEKLNNQLKALTEKNKEL--------EIAQDRNIAI 109
Query: 1764 EGNVSK-QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
+ ++ + LEA ++ +TN E +Q + TE+ L+ + + + +
Sbjct: 110 QSQFTRTKEELEAEKRDLIRTN--ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD 167
Query: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNT----LLSQIS 1878
+ D S Q+ + L + L E + + L EK L +
Sbjct: 168 ELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLE 227
Query: 1879 TKDGELKMLQEEVTKMNLLNQQIQEEL-SRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937
K E+ L+E++ + N+ +Q+ + +TKLKE A+E++ +EE+ N+L
Sbjct: 228 NKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKE-AKEQQASMEEKFHNELNAHIKLS 286
Query: 1938 GNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE---SEIRKEYLEKI 1994
Y D++ K+ L ++ L K + E E + + +VE ++ KE LEKI
Sbjct: 287 NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKI 346
Query: 1995 QGAQKEPGNK----SHAKELQELLKEKQ--------QEVKQLQKDCIRYQEKISALERTV 2042
+KE N S K +L E++ V ++ K ++ E +A T
Sbjct: 347 GRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQ 406
Query: 2043 KALEFVQTESQ----------KDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA 2092
L + E++ K++E L + E ++AQ +AS V L+ E
Sbjct: 407 DQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQ 466
Query: 2093 RVLADNLKLKKE---LQSNKESVKSQMKQKDEDLERRLEQAEE----------------- 2132
R+ D K K+ L+ + ++ Q+K + + L + EE
Sbjct: 467 RLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADI 526
Query: 2133 --------KHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE-----VQQLQEN 2179
+HL +N++E L+++ L + E+ T ++++E + +LQ
Sbjct: 527 SSSSEVISQHLVSYRNIEE----LQQQNQRLLVALRELGETREREEQETTSSKITELQLK 582
Query: 2180 LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ 2239
L+S +T+L KS ++ + + D+I + + R +L Q
Sbjct: 583 LESALTELEQLRKS---------------RQHQMQLVDSIVRQRDMYR-------ILLSQ 620
Query: 2240 LRQMSIHMEELKI-NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298
++I + + ++S K+ S+ + + T E K L QL+E
Sbjct: 621 TTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFE 680
Query: 2299 LYHSSQNELAKLESE-LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE 2357
Y + E K+++E L+ L++Q+TDL + K Q + + YE
Sbjct: 681 NYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQ--------------LDFASKRYE 726
Query: 2358 QLETDLQASRELTSRLHEE------INMKEQKIISL----LSGKEEAIQVAIAELRQQHD 2407
L+ +++ R + LHE K+++II+ L G E ++A+AE+R ++
Sbjct: 727 MLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE--KLAVAEVRAENL 784
Query: 2408 KEIKEL------------ENLLSQEEEENIVLEE-------ENKKAVDKTNQLMETLKTI 2448
K+ KE+ E+LL+++ +N++L + + +L ++ +
Sbjct: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844
Query: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508
+ E K +L++ V+ +L + D + D ++ + ++ L +L++ A E L
Sbjct: 845 EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
Query: 2509 KEEIRGL-------------------RSHMDDLNSENAKLDAELIQYREDLNQVITIKDS 2549
K+ + + + +DDL S+ + + ++ +E L + +
Sbjct: 905 KQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQ 964
Query: 2550 QQKQLLEVQLQQNKE---LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS----K 2602
Q + ++ NKE E +E +LKES E L + +++EKQ+L +
Sbjct: 965 YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRR 1024
Query: 2603 EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL 2662
IES++ +S+L + ++++Q E +E + R S S+ Q+ + +E+
Sbjct: 1025 AIESMEQQLSELKKTLSSVQNE------------VQEALQRASTALSNEQQARRDCQEQ- 1071
Query: 2663 VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELA---RDLVEMEQKL 2719
AK E ++K ++EL + H A + + A+E+V+++A + L E QK
Sbjct: 1072 -------AKIAVEAQNKYEREL--MLHAADV--EALQAAKEQVSKMASVRQHLEETTQKA 1120
Query: 2720 LMVTKENKG--------LTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQ- 2770
E K L ++ L+ ++++++L K AS+KE Q
Sbjct: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180
Query: 2771 -----LKEQGLLNRE---------RDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
L E+G + R+ ++ET F + E SL + +++ +LL + +
Sbjct: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVE--SLRYRQRV--ELL--ERE 1234
Query: 2817 LLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEV 2876
L L L +VQ +K MA Q+E E +K+E +
Sbjct: 1235 LQELQDSLNAEREKVQVTAKTMA--QHE--------ELMKKTE---------------TM 1269
Query: 2877 QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA-FQIMQ 2935
+ + L+ +++RL ++L+ +Q + ++ +I L A+L E +A ++++
Sbjct: 1270 NVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLE 1329
Query: 2936 EELRQENLSWQH--------ELHQLRMEKSSWEIHERRMKE------QYLMAISDKDQQL 2981
E++++ QH + + R S E+H +R+++ + I+ + L
Sbjct: 1330 EDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASL 1389
Query: 2982 SHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEI 3041
++ QNLI+ L+ ++ + K Q+ + + + + + + + + +E+
Sbjct: 1390 TNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTIT-QVKKIGRRYKTQYEEL 1448
Query: 3042 HQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQ 3101
++ ++ + ++ S +E++ ++ + ++L + + L + L+K + E +
Sbjct: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKE 1508
Query: 3102 AGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEER 3161
N+ ++ V +S+ LR+ Q + ++QL RQ++ E E+ R
Sbjct: 1509 TEARNL--------QEQTVQLQSELSRLRQDLQDRTTQEEQL---RQQITEKE---EKTR 1554
Query: 3162 DQRVAAENALS 3172
VAA++ ++
Sbjct: 1555 KAIVAAKSKIA 1565
Score = 195 bits (496), Expect = 5e-49
Identities = 339/1650 (20%), Positives = 705/1650 (42%), Gaps = 219/1650 (13%)
Query: 49 DVQERLAYA-EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSL 107
++++RL+++ E+LV E ++ L+ + E L + KA K K+L++ +
Sbjct: 56 EIEKRLSHSQERLVNETREC-----QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQ 110
Query: 108 NKYI---EEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ 164
+++ EE++A+ ++ T E+LS+ + TE+ ++++ KL+E LQ
Sbjct: 111 SQFTRTKEELEAEKRDLIRTN----ERLSQELEYLTED---VKRLNEKLKESNTTKGELQ 163
Query: 165 AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVV---RE 221
+L + QA + E ++L++++E + + L+ T+ + +++ RE
Sbjct: 164 LKLDELQASDVSVKYRE--------KRLEQEKELLHSQNTWLN-TELKTKTDELLALGRE 214
Query: 222 KD---ARFETQVRLHEDELLQLVTQAD----VETEMQQKLRVLQRKLEEHEESLVGRAQV 274
K + + ++E+ +L Q + +Q+ + L KL+E +E +A +
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQ---QASM 271
Query: 275 VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET------EREESKILLEKMELEV 328
+ EL A + + + EA+ N L VE E E+ ++ LEV
Sbjct: 272 EEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
Query: 329 AERKLSFHN-LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKT 387
+ K + E++ L ++ E A + + + + L ++ A M + + + K
Sbjct: 332 EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKP 391
Query: 388 GQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447
G +L +A + +LL +K E +++ L + KE+ L Q+ E
Sbjct: 392 GMKLTELYNAYVETQDQLLLEKLEN--------KRINKYLDEIVKEVEAKAPILKRQREE 443
Query: 448 -TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSS 506
+Q + + + QA+ E I LQ+ + N++ ++L E++ ++
Sbjct: 444 YERAQKAVASLSVKLEQAMKE--IQRLQEDT-DKANKQSSVLERDNRRMEIQVKDLSQQI 500
Query: 507 QITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLE----NTFSQKHKELSVL 562
++ L+E + G E+S DI SSS+E Q ++ Q+++ L V
Sbjct: 501 RVLLMELEEARGNHVIRDEEVSSADI----SSSSEVISQHLVSYRNIEELQQQNQRLLVA 556
Query: 563 LLEMKEAQE---------EIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613
L E+ E +E +I L+L+L+ E Q +M+ ++ ++
Sbjct: 557 LRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI 616
Query: 614 FL-EDTGQDFPLMPN--EESSLPAVEKEQASTEHQSRTS-----EEISLNDAGVELKSTK 665
L + TG PL + ++ SL + K ++++ S + E +A LK +
Sbjct: 617 LLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQ 676
Query: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILEL---------ELNF-HKAQEIYEKNLDEKA 715
+ + + + ++LE+L+ Q+ +L +L+F K E+ + N++
Sbjct: 677 EIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYR 736
Query: 716 KEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAE 775
+EI++L++ + TA +++++Q+++ +M +LR ++L +
Sbjct: 737 REITSLHE-----------RNQKLTATTQKQEQIIN-----TMTQDLRGANEKLAVAEVR 780
Query: 776 AERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ--LQFSEQSTLI 833
AE ++ + E + L++Q SL E + +++ + LQ +Q L+ SE T
Sbjct: 781 AENLKK-EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT----IQGILERSETETKQ 835
Query: 834 RSLQSQLQNKESEV------LEGAERVRHISSKVEELSQALSQKELEIT-----KMDQLL 882
R L SQ++ E E+ LE RH ++ ++ ++++L+ +LL
Sbjct: 836 R-LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
Query: 883 LEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS-LGVEIKTLKEQLNLLSRA 941
++++ TL+Q + + QV S T K N+E L +++ +EQ+N L
Sbjct: 895 KNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER 954
Query: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
+ VE+ + + L+++ ++ EE++ ++ KE+ + + +L+ L+
Sbjct: 955 LKTSTSNVEQYQAMVTSLEESLNKEKQV----TEEVRKNIEVRLKESAEFQTQLEKKLME 1010
Query: 1002 ----RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057
++EL R E + E KK + + E E + +E+ CQE
Sbjct: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
Query: 1058 IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALV---KQMNQTLQDKTNQIDLLQAE 1114
+ ++ E EL D+E AA+EQ + + + +T Q +Q+ +A
Sbjct: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKAS 1130
Query: 1115 ISENQAIIQ-----------------KLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157
E + +++ +L+ + VA VKE V P SE
Sbjct: 1131 WEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ-GPLNVSLSEE 1189
Query: 1158 WKPELEEKILAL------EKE-------------------KEQLQKKLQEALTSRKAILK 1192
K +E+IL + EKE E L+++LQE S A +
Sbjct: 1190 GKS--QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247
Query: 1193 KAQ--EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS 1250
K Q K EEL ++ + N + E +E E + L+Q+Q +VR+ LP
Sbjct: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
Query: 1251 TDQQESCSSTPGLEEPLFKATEQH------HTQPVLESNLCPDWPSHSEDASALQGGTSV 1304
+ S G+ + K E+ Q ++ PD + + S + T
Sbjct: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTK- 1366
Query: 1305 AQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364
+++++ E L+ +++ + + LT + L+E +NK E E T+ + +
Sbjct: 1367 -----RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE---TIQKDLD 1418
Query: 1365 VHAESLQQKLES-SQLQIAG------LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
+Q+K+++ +Q++ G E L+ Q K+ E S ++ ++ E
Sbjct: 1419 AKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQE 1478
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQL---EMQAKEHDERIKQLQVELCEMKQK-PEEIGE 1473
+ L + +T+ E ++ L L E +A+ E+ QLQ EL ++Q + +
Sbjct: 1479 LKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQ 1538
Query: 1474 ESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKE 1533
E + +QQI K ++ K + + +++ G ++LTK +++ + A +++
Sbjct: 1539 EEQLRQQITEK-------EEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQ 1591
Query: 1534 KDTVLGRLALLQEERDKLITEMDRSLLENQ 1563
KD + R+ L+ + + I+ ++R L E+Q
Sbjct: 1592 KDELDVRITALKSQYEGRISRLERELREHQ 1621
Score = 190 bits (482), Expect = 2e-47
Identities = 340/1729 (19%), Positives = 716/1729 (41%), Gaps = 299/1729 (17%)
Query: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFE-QAGQAQAELESRYSALEQKHKAEMEE 376
K + K+E +A+++ L+ E+F+ ++ Q E+E R S +++ E E
Sbjct: 19 KSVQNKLEKFLADQQSEIDGLKGRH----EKFKVESEQQYFEIEKRLSHSQERLVNETRE 74
Query: 377 KTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ 436
S L L+K +L++ + K++ ++ QD+N A+QS T + +++L+ + +++ +
Sbjct: 75 CQSLRLELEKLNNQLKALTE--KNKELEIAQDRN-IAIQSQFT--RTKEELEAEKRDLIR 129
Query: 437 FLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELE- 495
RL ++ + +TE+ + L +++ E KG L L EL+
Sbjct: 130 TNERL-----------------SQELEYLTED-VKRLNEKLKESNTTKGELQLKLDELQA 171
Query: 496 ----------ELKAENEKLSSQITLLEAQNRT---------GEADREVSEISIVDIANKR 536
L+ E E L SQ T L + +T E E+ E+ K
Sbjct: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKE 231
Query: 537 SSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK-----RAEEADHE 591
S E + L+ + K + LL ++KEA+E+ A ++ + + +
Sbjct: 232 EVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKS 291
Query: 592 VLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEE 651
D E K E A ++ L++ G+ N+ +E EQ+ + + E+
Sbjct: 292 AADDSEAKSNELTR-AVEELHKLLKEAGE-----ANKAIQDHLLEVEQSKDQMEKEMLEK 345
Query: 652 I-----SLNDAGVELKSTKQDG----DKSLSAVPDIGQCHQD------ELERLKSQILEL 696
I L +A L +TK+ G ++ L+A+ +L L + +E
Sbjct: 346 IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVET 405
Query: 697 --ELNFHKAQ-EIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV 753
+L K + + K LDE KE+ +++ ++ + A +LS + +Q + ++
Sbjct: 406 QDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465
Query: 754 KELSMVTE--------LRAQVKQLEMNLAEAERQRR---LDYESQTAHDNLLTEQIHSLS 802
+ L T+ L +++E+ + + +Q R ++ E + + E++ S
Sbjct: 466 QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
Query: 803 IEAKSKDVKIEVLQ-NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKV 861
I + S+ + ++ ++++Q Q +R L + +E E SSK+
Sbjct: 526 ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET---------TSSKI 576
Query: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKD------------------QQV 903
EL L E +T+++QL ++ ++ + + ++D +
Sbjct: 577 TELQLKL---ESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSL 633
Query: 904 TEISFSMTEKMVQLNEE----------KFSLGVEIKTLKEQLNLL--------SRAEEAK 945
++S + T K ++ + + +E K +QL + + E+ +
Sbjct: 634 DDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQ 693
Query: 946 KEQVEEDNEVSSGLKQNYDEMSPAGQISK---EELQHEFDLLKKE---NEQRKRKLQAAL 999
EQ+E+ E + L+ ++S + E LQ + ++E +R +KL A
Sbjct: 694 NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATT 753
Query: 1000 INRKELLQRVSR----LEEELA-------NLKDESKKEIPLSETERGEVEEDKENKEYSE 1048
+++++ +++ E+LA NLK E K+ + LSE + E ++ +
Sbjct: 754 QKQEQIINTMTQDLRGANEKLAVAEVRAENLKKE-KEMLKLSEVRLSQQRESLLAEQRGQ 812
Query: 1049 KCVTSKCQEIEIYLKQT-----------ISEKEVELQHIRKDLEEKLAAEEQFQALVKQM 1097
+ + Q I+ L+++ I + E E+ H++K LE ++ EQ L + +
Sbjct: 813 NLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEV---EQRHTLTRNL 869
Query: 1098 NQTLQDKTNQID-----------LLQ------AEISENQAIIQKLITSNTDASDGDSVAL 1140
+ L D Q+D LL+ A + ++ + ++ + S + G
Sbjct: 870 DVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPS 929
Query: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQ---KKLQEALTSRKAILKKAQEK 1197
KE V +E +L+E++ EQ Q L+E+L K + +E
Sbjct: 930 NKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQV---TEEV 986
Query: 1198 ERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQ----LQIQVRE------SIDGK 1247
+++ LK+ + +L+++ E KE + + D R+ ++ Q+ E S+ +
Sbjct: 987 RKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
Query: 1248 LPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG----TS 1303
+ Q+ S ++ ++ EQ ++ + H+ D ALQ +
Sbjct: 1047 VQEALQRAS-TALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSK 1105
Query: 1304 VAQIKAQLKEI--EAEKVELELKVSSTTSELTKKSE--------------------EVFQ 1341
+A ++ L+E +AE LE K S E K E ++ +
Sbjct: 1106 MASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEK 1165
Query: 1342 LQEQI---NKQGLEIESLKTVSHEAEVHAESL--------QQKLESSQLQIAGLEHLRE- 1389
L +++ K+G++ ++S E + + L ++++ ++ ++A +E LR
Sbjct: 1166 LSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYR 1225
Query: 1390 -----LQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT--EIIEQEDLIKALHTQ 1442
L+ +L ELQ ++ + E V + +++ E + K +T ++E +++ +
Sbjct: 1226 QRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKER 1285
Query: 1443 LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSL 1502
LE ++ ++++L++++ +++ E+ E+S Q E K L
Sbjct: 1286 LEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQ-----------------AEKKLL 1328
Query: 1503 QEELSLARGTIERLTKSLADVESQVSAQ-NKEKDTVLGRLALLQEERDKLITEMDR---S 1558
+E++ + + L D +++ + EK+ R+ L EE +L E+ R S
Sbjct: 1329 EEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNAS 1388
Query: 1559 LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL---KSSKIAESTEWQEKHKELQKEY 1615
L NQ+L +SLK L + +KE + K++++ K+ T+ ++ + + +Y
Sbjct: 1389 LTNNQNL---IQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQY 1445
Query: 1616 EILLQSYENV------SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQ 1669
E L + V S+ + QHV QE QEL L E K E Q++ ++
Sbjct: 1446 EELKAQQDKVMETSAQSSGDHQEQHVSV---QEMQELKETLNQAETKSKSLESQVENLQK 1502
Query: 1670 EMEEMKEKMRKFAKSKQQKILELEE----------ENDRLRAEVHPAGDTAKECMETLLS 1719
+ E + + R + Q EL + ++LR ++ + ++ + S
Sbjct: 1503 TLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS 1562
Query: 1720 SNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK--QANLEATE 1777
A + +++ E E L ++ +L +KD L + LK Q EG +S+ + E E
Sbjct: 1563 KIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Query: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVS 1826
+H Q + +E + +P E+Q +++ T P E ++ S P +
Sbjct: 1623 RHLEQRDEPQEPSNKVP---EQQRQITLKTTPASGERGIASTSDPPTAN 1668
Score = 152 bits (384), Expect = 5e-36
Identities = 275/1346 (20%), Positives = 538/1346 (39%), Gaps = 196/1346 (14%)
Query: 1942 QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV--KEKTKVESEIRKEYLEKIQGAQK 1999
Q V + N+L +S L+K +++ + E L EK KVESE ++Y E
Sbjct: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESE--QQYFE------- 56
Query: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059
+++ L Q+ + ++C + ++ L +KAL TE K+LEI
Sbjct: 57 ----------IEKRLSHSQERLVNETRECQSLRLELEKLNNQLKAL----TEKNKELEIA 102
Query: 2060 KE-NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
++ N+A QS+ R + K++L E + +++
Sbjct: 103 QDRNIA----------------------IQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
Query: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQE 2178
ED++R E+ +E + K +Q KLD L+ V++ ++K ++Q +E
Sbjct: 141 LTEDVKRLNEKLKESNTT-KGELQLKLDELQAS-----------DVSVKYREKRLEQEKE 188
Query: 2179 NLDSTVT----QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
L S T +L T + +L ++ I E K +++K+EE+ E+ +
Sbjct: 189 LLHSQNTWLNTELKTKTDELLALGREKGNEILELKC-------NLENKKEEVSRLEEQMN 241
Query: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQ-------LQQKVCDTLQGENK 2287
LK + H+E+L + + + E K E+ L + D + ++
Sbjct: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
Query: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR-QQE 2346
EL +EE L L + K+++D L ++ S K + +K LE I R ++E
Sbjct: 302 ELTRAVEELHKL-------LKEAGEANKAIQDHLLEVEQS--KDQMEKEMLEKIGRLEKE 352
Query: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406
+ N S + + + + EL + ++ + ++ + ++ A + Q
Sbjct: 353 LENANDLLSATKRKGAILSEEELAA-----MSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
Query: 2407 DKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSM 2466
+++LEN + + IV E E K + K + E + +K +L+ +K +
Sbjct: 408 QLLLEKLENKRINKYLDEIVKEVEAKAPILKRQR--EEYERAQKAVASLSVKLEQAMKEI 465
Query: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE-----IRGLRSHMDD 2521
LQ D D+ LE + + ++ L Q+ +L+E IR D
Sbjct: 466 QRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
Query: 2522 LNSENAKLDAELIQYR--EDLNQVITIKDSQQKQLLEVQLQQNKEL-ENKYAKLEEKLKE 2578
++S + + L+ YR E+L Q ++L E + ++ +E +K +L+ KL+
Sbjct: 526 ISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLES 585
Query: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638
+ E LR+S + + ++ + ++ +SQ T L + A +
Sbjct: 586 ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRP 645
Query: 2639 EEVHRLSA-----LFSSSQ--------KRIAELEEELVCVQKEAAKKVGEIEDKLKKELK 2685
+S + S++ K++ E+ E + E K E +KL++++
Sbjct: 646 STSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVT 705
Query: 2686 HLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN 2745
L + + + A +R L ++ +++ + + N+ LTA Q + ++++
Sbjct: 706 DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765
Query: 2746 SRDHANEELDELKRKYDASLKELAQLK-EQGLLNRERDALLSETAF-------------- 2790
ANE+L + + + KE LK + L+++R++LL+E
Sbjct: 766 DLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGI 825
Query: 2791 ---SMNSTEENSLSHLEKLNQQL--LSK----------------DEQLLHLSSQLEDSYN 2829
S T++ S +EKL ++ L K D QLL QL+ N
Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885
Query: 2830 QVQSFSKAMASLQNE----RDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS 2885
+ + + + Q E + HL N +E S+ ++ QPS +V L +
Sbjct: 886 LHLNTKELLKNAQKEIATLKQHLSN-MEVQVASQSSQRTGKGQPSNKE-DVDDLVSQLRQ 943
Query: 2886 LQNDRDRLLKELKNLQQQYLQINQEITELHP-LKAQLQEYQDKTKAFQIMQEELRQENLS 2944
+ + L + LK Q +T L L + Q ++ K ++ +E +
Sbjct: 944 TEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ 1003
Query: 2945 WQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
+ +L ++ EK + +RR E +S+ + LS +QN ++E +S + Q
Sbjct: 1004 LEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQ 1063
Query: 3005 YQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNT 3064
+R + + + YE EL+ + ++ + + ++ ++ S L E
Sbjct: 1064 ARRDCQEQAKIAVEAQNK--YERELMLHAAD--VEALQAAKEQVSKMASVRQHLEETTQK 1119
Query: 3065 LSIQLCDTSQSLRENQQHYGDLLNHCAV----LEKQ------------------VQELQA 3102
QL + S E ++ D ++ C LEKQ V+E
Sbjct: 1120 AESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQ 1179
Query: 3103 GPLNIDVA-PGAPQEK-----NGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156
GPLN+ ++ G QE+ + R+ + E R F AQ + RQ V L +
Sbjct: 1180 GPLNVSLSEEGKSQEQILEILRFIRREKEIAETR-----FEVAQVESLRYRQRVELLERE 1234
Query: 3157 LEEERDQRVAAENALSVAEEQIRRLE 3182
L+E +D A + V + + + E
Sbjct: 1235 LQELQDSLNAEREKVQVTAKTMAQHE 1260
Score = 130 bits (328), Expect = 2e-29
Identities = 206/993 (20%), Positives = 425/993 (42%), Gaps = 152/993 (15%)
Query: 36 QESDMEFNNTTQE--DVQERLAYAEQLVVELK---DIIRQKDVQLQQKDEALQEERKAAD 90
Q+ + N TQ+ E+LA AE LK ++++ +V+L Q+ E+L E++
Sbjct: 754 QKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ- 812
Query: 91 NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIK 150
N + ++ G + +E +++++LS + E EI +K
Sbjct: 813 -----------------NLLLTNLQTIQGILERSETETKQRLSSQIEKL---EHEISHLK 852
Query: 151 HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ 210
KL+ + E TL L + Q TE + K+ L+ ++ I+TL+ LS +
Sbjct: 853 KKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNME 912
Query: 211 AEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVET-EMQQKLRVLQRKLEEH----- 264
+ A+Q ++ + + + D+L+ + Q + + +++++L+ +E++
Sbjct: 913 VQVASQS--SQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT 970
Query: 265 --EESLVGRAQVVDLLQQELT-----AAEQRNQILSQQLQQMEAEHNTLRNTVETEREES 317
EESL QV + +++ + +AE + Q L ++L ++E E L+ ++
Sbjct: 971 SLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQ-LEKKLMEVEKEKQELQ-------DDK 1022
Query: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQ-KHKAEMEE 376
+ +E ME +++E K + ++Q E+ L++ A E ++R EQ K E +
Sbjct: 1023 RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA--LSNEQQARRDCQEQAKIAVEAQN 1080
Query: 377 KTSHILSLQKTGQELQSACDALKDQNSKLLQDKN--EQAVQSAQTI-----QQLEDQLQQ 429
K L L E A A K+Q SK+ + E+ Q A++ E++ +
Sbjct: 1081 KYERELMLHAADVE---ALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERM 1137
Query: 430 KSKEISQFL---------NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL 480
E+S+ + NRL Q E S V EG Q +++ K
Sbjct: 1138 LKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASV-KEGVQGPLNVSLSEEGK----- 1191
Query: 481 ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
E+ +L I E+ AE +Q+ L + R +RE+ E+ D N
Sbjct: 1192 SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQ--DSLNAEREKV 1249
Query: 541 EESGQDVLENTFSQKHKELSVLLLE----MKEAQEEIAFLKLQLQGK-RAEEADHEVLDQ 595
+ + + + ++ K E +++E ++E +E + Q+Q K R E D L +
Sbjct: 1250 QVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQE 1309
Query: 596 KEMKQMEGEGIAPIKMKVFLEDT----GQDFPLM-----PNEESSLPAVEKEQASTEHQS 646
+ E G+ + K+ ED ++ L+ P+ E + +++ T+
Sbjct: 1310 ANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ 1369
Query: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
+ +EEI LK+ + SL+ ++ Q +++L +++++ +E
Sbjct: 1370 QLTEEIG------RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTE-----------KET 1412
Query: 707 YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQV 766
+K+LD K +I + I + KK + + L ++D+++
Sbjct: 1413 IQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVM---------------- 1456
Query: 767 KQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQF 826
E Q D++ Q ++ +++ L + K + L+++++++Q
Sbjct: 1457 --------ETSAQSSGDHQEQ----HVSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
Query: 827 SEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKK 886
SE+ T R+LQ Q +SE+ + ++ +++ E+L Q +++KE K + ++ K
Sbjct: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKE---EKTRKAIVAAK 1561
Query: 887 RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL-NLLSRAEEAK 945
+ L KD Q+T+ + + ++ L+++K L V I LK Q +SR E
Sbjct: 1562 SKIAHLAGV---KD-QLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLEREL 1617
Query: 946 KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
+E E L+Q + P+ ++ +++ Q
Sbjct: 1618 REHQERH------LEQRDEPQEPSNKVPEQQRQ 1644
Score = 92.4 bits (228), Expect = 6e-18
Identities = 123/615 (20%), Positives = 273/615 (44%), Gaps = 67/615 (10%)
Query: 24 QNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ 83
Q M L+ L++E + E+V++ + + E + + +K ++++++ + LQ
Sbjct: 966 QAMVTSLEESLNKEKQVT------EEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019
Query: 84 EERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEE 143
++++ A +++ K L+S+ ++E + T L E Q+ + K + E +
Sbjct: 1020 DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQ 1079
Query: 144 MEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQ 203
+ E+E ++ + QA EQ ++ ++ + +++ Q+ E + +
Sbjct: 1080 NK--------YERELMLHAADVEALQAAKEQVSKMASVRQH---LEETTQKAESQLLECK 1128
Query: 204 AQLSQTQ---AEQAAQQVVREKDARFETQVRLHEDELLQLVTQ--ADVETEMQQKLRVLQ 258
A + + ++ ++ V R +D E Q RL D++ +L + A V+ +Q L V
Sbjct: 1129 ASWEERERMLKDEVSKCVCRCED--LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV-- 1184
Query: 259 RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS-------QQLQQMEAEHNTLRNTVE 311
L E +S +++ +++E AE R ++ Q+++ +E E L++++
Sbjct: 1185 -SLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN 1243
Query: 312 TEREESKILLEKM-ELEVAERKLSFHNLQEEMHHLL-EQFEQAGQAQAELESRYSALE-- 367
ERE+ ++ + M + E +K N+ E + +L E+ E+ Q +++++ LE
Sbjct: 1244 AEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELD 1303
Query: 368 ----QKHKAEMEEKTSHILSLQKTGQE------------LQSACDALKDQNSKLLQDKNE 411
Q+ AE+ EK+ + + +K +E + D ++ KLL +K
Sbjct: 1304 ILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEV 1363
Query: 412 QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT----- 466
+ IQQL +++ + EI++ + L ++ Q+ D+ T+ T
Sbjct: 1364 H----TKRIQQLTEEIGRLKAEIAR--SNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL 1417
Query: 467 EENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD-REVS 525
+ I +Q++V + K + EELKA+ +K+ ++ +E+
Sbjct: 1418 DAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQ 1477
Query: 526 EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRA 585
E+ + S + ES + L+ T S+K E L + + Q E++ L+ LQ +
Sbjct: 1478 ELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537
Query: 586 EEAD-HEVLDQKEMK 599
+E + + +KE K
Sbjct: 1538 QEEQLRQQITEKEEK 1552
Score = 89.0 bits (219), Expect = 7e-17
Identities = 183/812 (22%), Positives = 341/812 (41%), Gaps = 133/812 (16%)
Query: 2488 LSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL------IQYREDLN 2541
L +LE+ +L + + NKL++ + +S +D L + K E I+ R +
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64
Query: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE-------DLRRSFNALQ 2594
Q + ++++ Q L ++L+ +L N+ L EK KE E A + R+ L+
Sbjct: 65 QERLVNETRECQSLRLELE---KLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELE 121
Query: 2595 EEKQDLSKEIESLKVSISQLTRQVTALQEE-GTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
EK+DL + E L + LT V L E+ +L++K +E+ +K
Sbjct: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREK 181
Query: 2654 RIAELEE------------------ELVCVQKEAAKKVGEIEDKL---KKELKHLHHDAG 2692
R+ + +E EL+ + +E ++ E++ L K+E+ L
Sbjct: 182 RLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMN 241
Query: 2693 IMRNETETAEERVAELARDLVE-MEQKLLMVTKENKGLTAQIQSFGRSMSSL-QNSRDHA 2750
++ E ++ V +L L E EQ+ M K + L A I+ +S+L +++ D +
Sbjct: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK-----LSNLYKSAADDS 296
Query: 2751 NEELDELKRKYDASLKELAQ-LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQ 2809
+ +EL R +++EL + LKE G N+ L E S + E+ L + +L ++
Sbjct: 297 EAKSNELTR----AVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
Query: 2810 LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQP 2869
L ++ N + S +K ++ +E + AA
Sbjct: 353 L---------------ENANDLLSATKRKGAILSE------------------EELAAMS 379
Query: 2870 STSPAEVQSLKKAM-------SSLQNDRDRLLKELKNLQ-QQYL-QINQEITELHP-LKA 2919
T+ A + +K M + ++ LL++L+N + +YL +I +E+ P LK
Sbjct: 380 PTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKR 439
Query: 2920 QLQEYQDKTKA---FQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISD 2976
Q +EY+ KA + E+ +E Q + + + S E RRM+ Q + D
Sbjct: 440 QREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQ----VKD 495
Query: 2977 KDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDG-SQNLV-----YETELL 3030
QQ+ L + E R + ++ + +S + S+S + SQ+LV E +
Sbjct: 496 LSQQIRVLLMELEEARGNH------VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Query: 3031 RTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHC 3090
+L +L+E+ + R +Q + S++ E + L L + Q LR+++QH L++
Sbjct: 550 NQRLLVALRELGETREREEQ-ETTSSKITELQLKLESALTELEQ-LRKSRQHQMQLVD-S 606
Query: 3091 AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQ-- 3148
V ++ + + P + V S P+ Q + A + + +
Sbjct: 607 IVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI 666
Query: 3149 EVNELRKLLEE--ERDQRVAAENALSVAEEQIRRLEHSEWD--SSRTPIIGSCGTQEQAL 3204
E K L+E E ++ AEN + EQ+ +L+ D S T I TQ
Sbjct: 667 EAKAALKQLQEIFENYKKEKAENE-KIQNEQLEKLQEQVTDLRSQNTKI----STQ---- 717
Query: 3205 LIDLTSNSCRRTRSGV-GWKRVLRSLCHSRTR 3235
+D S + V G++R + SL H R +
Sbjct: 718 -LDFASKRYEMLQDNVEGYRREITSL-HERNQ 747
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 214 bits (546), Expect = 9e-55
Identities = 274/1263 (21%), Positives = 532/1263 (42%), Gaps = 189/1263 (14%)
Query: 1586 LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQE 1645
L++E+ + S+I + Q + + EY+ LL+ +++ I+ + +
Sbjct: 772 LLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMK 831
Query: 1646 LYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA---KSKQQKILELEEENDRLRAE 1702
LY K++ E EK++ ++E +KE + K K ++K++ L +E + L+ +
Sbjct: 832 LYFKIKPL-LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQ 890
Query: 1703 VHPAGDT---AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
V D A+E + L+ + ++ +++ + E + L ++K L +E +L
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Query: 1760 KHQIEGNVSKQANLEAT-EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSA 1818
K I+ +LE T K + + + TE +++ TEE L E
Sbjct: 951 KRDID-------DLELTLAKVEKEKHATENKVKNL---TEEMAGLDEIIAKLTKEKKALQ 1000
Query: 1819 KSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
++ A+ + D++N + +L++++ LE ++ K+ LE K L
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKL----- 1055
Query: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIG 1938
+G+LK+ QE + + E +K L+ERL + ELN
Sbjct: 1056 --EGDLKLTQESIMDL---------------------ENDKQQLDERLKKKDFELNALNA 1092
Query: 1939 NYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE---SEIRKEYLEKIQ 1995
+ D Q L+ ++K L+ + ELEEE + + KVE S++ +E LE+I
Sbjct: 1093 R----IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE-LEEIS 1147
Query: 1996 GAQKEPG---------NKSHAKELQELLKEKQQEVKQLQKDCIRYQEK-----------I 2035
+E G NK E Q++ ++ ++ Q + ++K I
Sbjct: 1148 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1207
Query: 2036 SALERTVKALEFVQTESQKDLEITKENLAQAV------------------EHRKKAQAEL 2077
L+R + LE ++E + +L+ N+ Q + EHR KA+
Sbjct: 1208 DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQ 1267
Query: 2078 ASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK-------QKDEDLERRLEQ- 2129
S ++D S+ A++ +N +L ++L KE++ SQ+ Q+ EDL+R+LE+
Sbjct: 1268 RS----VNDLTSQRAKLQTENGELSRQLDE-KEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 2130 --AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187
A+ ++ + D LR + E E+Q L+K + EV Q + ++ Q
Sbjct: 1323 VKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ- 1381
Query: 2188 AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHM 2247
R ++EAKK K + +Q EE + CS L+ ++ +
Sbjct: 1382 -------------RTEELEEAKK---KLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI 1425
Query: 2248 EELKINISRLE------------HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEE 2295
E+L +++ R DK + E K + E Q ++ Q E + L ++L +
Sbjct: 1426 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES--QSELESSQKEARSLSTELFK 1483
Query: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
++ Y S L + E K+L+++++DL+ L + LE + +Q EA+ + +
Sbjct: 1484 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSA 1543
Query: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
E+ E L+ R E N + +I L+ K+E ++ A ++ H + + L+
Sbjct: 1544 LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA----KRNHLRVVDSLQT 1599
Query: 2416 LLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
L E KK N++ L + + + Q+ S + Q D
Sbjct: 1600 SLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
Query: 2476 IVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ 2535
V L+E +++I+ + NN L+ E+ LR+ ++ + ELI+
Sbjct: 1660 AVRANDDLKE-NIAIVERR----------NNLLQAELEELRAVVEQTERSRKLAEQELIE 1708
Query: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN--AL 2593
E + + SQ L+ + + + +L ++EE ++E A E +++ A+
Sbjct: 1709 TSER----VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAM 1764
Query: 2594 QEE----KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFS 2649
E +QD S +E +K ++ Q + + +E LK ++++ +L A
Sbjct: 1765 MAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE----QIALKGGKKQLQKLEA--- 1817
Query: 2650 SSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELA 2709
R+ ELE EL QK A+ V + K ++ +K L + +TE + + L
Sbjct: 1818 ----RVRELENELEAEQKRNAESVKGMR-KSERRIKELTY-------QTEEDRKNLLRL- 1864
Query: 2710 RDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELA 2769
+DLV+ KL + K K + + + S H ELDE + + D + ++
Sbjct: 1865 QDLVD---KLQLKVKAYKRQAEEAEEQANTNLSKFRKVQH---ELDEAEERADIAESQVN 1918
Query: 2770 QLK 2772
+L+
Sbjct: 1919 KLR 1921
Score = 189 bits (481), Expect = 3e-47
Identities = 277/1267 (21%), Positives = 559/1267 (44%), Gaps = 204/1267 (16%)
Query: 1827 KDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKM 1886
K E+ + ++ +LKE + E +++ +E +L EKN L Q+ + L
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900
Query: 1887 LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTD 1946
+E + L+ +IQ E ++V ++ E E+E++ MN AEL
Sbjct: 901 AEERCDQ--LIKNKIQLE-AKVKEMNERLEDEEE------MN--AELTA----------- 938
Query: 1947 AQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGA--------- 1997
K LE E LK+ + +LE ++ KEK E+++ K E++ G
Sbjct: 939 ---KKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV-KNLTEEMAGLDEIIAKLTK 994
Query: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE 2057
+K+ ++H + L +L E + +V L K ++ ++++ LE +++ + + + DLE
Sbjct: 995 EKKALQEAHQQALDDLQAE-EDKVNTLTKAKVKLEQQVDDLEGSLEQ----EKKVRMDLE 1049
Query: 2058 ITKENLAQAVEHRKKAQAELASFKVLLDDT-QSEAARVLADNLKLKKELQSNKESVKSQM 2116
K L ++ +++ +L + K LD+ + + + A N +++ E +++ SQ+
Sbjct: 1050 RAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE-----QALGSQL 1104
Query: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR----REKVHLEETIGE------IQVTL 2166
++K ++L+ R+E+ EE+ L+ ++ + K++ LR RE + E + E +Q+ +
Sbjct: 1105 QKKLKELQARIEELEEE-LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163
Query: 2167 NKK-DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEE 2225
NKK + E Q+++ +L+ Q A ++ +K +D++ E+
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAAL-----------------RKKHADSVAELGEQ 1206
Query: 2226 IRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD-KQIWESKAQTEVQLQQKVCDTLQG 2284
I DN +K +L + E K+ + + + +QI ++KA E K+C TL+
Sbjct: 1207 I----DNLQRVKQKLEK---EKSEFKLELDDVTSNMEQIIKAKANLE-----KMCRTLED 1254
Query: 2285 ENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQ 2344
+ E S+ EET+ + ++ AKL++E L QL + E +I Q
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEK--------------EALISQ 1300
Query: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ 2404
+ K +Y Q DL+ +L EE+ K +L S + + LR+
Sbjct: 1301 ----LTRGKLTYTQQLEDLKR------QLEEEVKAKNALAHALQSARHDCDL-----LRE 1345
Query: 2405 QHDKEIK---ELENLLSQEEEENIVLEEENK---KAVDKTNQLMETLKTIKKENIQQKAQ 2458
Q+++E + EL+ +LS+ E V + K A+ +T +L E K + + + +
Sbjct: 1346 QYEEETEAKAELQRVLSKANSE--VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEA 1403
Query: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518
+++ SSL+ + R+ + + L +++ ++ AAA + K + + L
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDL-------MVDVERSNAAAAALDKKQRNFDKILAEW 1456
Query: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL--LEVQLQQNKELENKYAKLEEKL 2576
++L++ + R ++ +K++ ++ L LE ++NK L+ + + L E+L
Sbjct: 1457 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 2577 KESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKV 2636
S + +L + L+ EK +L +E + S+ EEG + AQL+
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH---------EEGKI--LRAQLEF 1565
Query: 2637 KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN 2696
+ + + ++++AE +EE+ ++ + V ++ L E + RN
Sbjct: 1566 NQ--------IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS--------RN 1609
Query: 2697 ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756
E +++ + DL EME +L + + A+ Q + + SLQ+ +LD+
Sbjct: 1610 EALRVKKK---MEGDLNEMEIQLSHANR----MAAEAQ---KQVKSLQSLLKDTQIQLDD 1659
Query: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
R D LKE + R+ LL + + E + + Q+L+ E+
Sbjct: 1660 AVRAND-------DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1712
Query: 2817 LLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEV 2876
+ L SQ NQ + ++ LQ E + +++ R +EE +++ + E+
Sbjct: 1713 VQLLHSQNTSLINQKKKMDADLSQLQTEVE---EAVQECRNAEEKAKKAITDAAMMAEEL 1769
Query: 2877 QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQE 2936
+ + + L+ + + + +K+LQ + + Q L K QLQ+ + + + ++
Sbjct: 1770 KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ--IALKGGKKQLQKLEARVRE---LEN 1824
Query: 2937 ELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSS 2996
EL E + +R ERR+KE D+ + L LQ+L+ +L+
Sbjct: 1825 ELEAEQKRNAESVKGMRKS-------ERRIKELTYQTEEDR-KNLLRLQDLVDKLQ---- 1872
Query: 2997 QTQPLKVQ-YQRQA-SPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSN 3054
LKV+ Y+RQA E A+ + S+ + EL + + E +LR + +
Sbjct: 1873 ----LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1928
Query: 3055 FSQLLEE 3061
L EE
Sbjct: 1929 TKGLNEE 1935
Score = 181 bits (460), Expect = 8e-45
Identities = 267/1272 (20%), Positives = 549/1272 (43%), Gaps = 174/1272 (13%)
Query: 852 ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEE----KDQQVTEIS 907
ER+ I ++++ S+ + + +E K LLE++ + +Q I K+ ++
Sbjct: 779 ERLSRIITRIQAQSRGVLAR-MEYKK----LLERRDSLLVIQWNIRAFMGVKNWPWMKLY 833
Query: 908 FSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRA---EEAKKEQVEED--------NEVS 956
F + + EK E+ ++KE+ L A EA+++++EE N++
Sbjct: 834 FKIKPLLKSAEREK-----EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQ 888
Query: 957 SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL 1016
++ D ++ A + + ++++ L K E +R +N EL + +LE+E
Sbjct: 889 LQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNA-ELTAKKRKLEDEC 947
Query: 1017 ANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHI 1076
+ LK ++I E +VE++K E K +T + ++ + + EK+ +
Sbjct: 948 SELK----RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 1077 RKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGD 1136
++ L++ A E++ L K + Q Q+D L+ + + + + L + +GD
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQ----QVDDLEGSLEQEKKVRMDLERAKRKL-EGD 1058
Query: 1137 SVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE--ALTSR-KAILKK 1193
+ L +E+++ E+ K +L+E++ + E L ++++ AL S+ + LK+
Sbjct: 1059 -LKLTQESIM-------DLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQ------LQIQVRESIDGK 1247
Q + L EEL+ ++ ++++ + S+E E I ++L + +QI++ + + +
Sbjct: 1111 LQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 1248 LPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
+ L +AT QH E+ H++ + L G + +
Sbjct: 1171 FQK------------MRRDLEEATLQH------EATAAALRKKHADSVAEL--GEQIDNL 1210
Query: 1308 KAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESL-KTVSHEAEVH 1366
+ +++E EK E +L++ TS + EQI K +E + +T+ + H
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNM-----------EQIIKAKANLEKMCRTLEDQMNEH 1259
Query: 1367 AESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
+ E Q +++L +K + + LS QL EKEA ++++
Sbjct: 1260 RSKAE-----------------ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLT 1302
Query: 1427 TEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQ 1486
+ ++ L QLE + K + LQ + E+ EE+ AK ++QR L
Sbjct: 1303 RGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1362
Query: 1487 AA--LISRKEALKENKSLQ--EELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542
A +++ E ++Q EEL A+ ++L + L + E V A N + ++
Sbjct: 1363 KANSEVAQWRTKYETDAIQRTEELEEAK---KKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1419
Query: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST 1602
LQ E + L+ +++RS +L + L + E+ E+ES + + ST
Sbjct: 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479
Query: 1603 EWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK 1662
E +L+ YE L+ E E + +Q + + E G T ++ K
Sbjct: 1480 EL----FKLKNAYEESLEHLETFKRENKNLQEEI----SDLTEQLGSSGKTIHELEKVRK 1531
Query: 1663 QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNA 1722
QL+ + E++ E+ + ++ KIL + E ++++AE+ A
Sbjct: 1532 QLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE--------------RKLA 1577
Query: 1723 SMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQ 1782
EE+E+ K + + Q+ + + E +K ++EG++++ +E H N+
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNE---MEIQLSHANR 1634
Query: 1783 TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ-Q 1841
+ E ++Q S + A AN + ++ + + NN LQ +
Sbjct: 1635 ----------MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE 1684
Query: 1842 IDQLK------ERIAGL-EEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
+++L+ ER L E+E + E Q L ++ +L++Q D +L LQ EV +
Sbjct: 1685 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEA 1744
Query: 1895 NLLNQQIQEELSR-VTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIK-NE 1952
+ +E+ + +T AEE K + + A L N Q + D Q + +E
Sbjct: 1745 VQECRNAEEKAKKAITDAAMMAEELKKE-----QDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012
+ +K KK + +LE ++L E +E+E +K E ++G +K +
Sbjct: 1800 AEQIALKGGKKQLQKLEARVRELENE---LEAE-QKRNAESVKGMRKS----------ER 1845
Query: 2013 LLKEKQQEVKQLQKDCIRYQEKISALERTVKAL--EFVQTESQKDLEITKENLAQAVEHR 2070
+KE + ++ +K+ +R Q+ + L+ VKA + + E Q + ++K Q
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905
Query: 2071 KKAQAELASFKV 2082
+ +A++A +V
Sbjct: 1906 AEERADIAESQV 1917
Score = 181 bits (459), Expect = 1e-44
Identities = 245/1107 (22%), Positives = 468/1107 (42%), Gaps = 154/1107 (13%)
Query: 2103 KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEI 2162
K L + E K K+E RL++A EK +K ++EK+ +L +EK L+ +
Sbjct: 837 KPLLKSAEREKEMASMKEEFT--RLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 2163 QVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSK 2222
Q L ++ QL +N QL A K M+ +D + + E +RK
Sbjct: 895 QDNLADAEERCDQLIKNK----IQLEAKVKEMNERLEDEEEMNAELTAKKRKL------- 943
Query: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT---EVQLQQKVC 2279
ED CS LK + ++L++ ++++E +K E+K + E+ ++
Sbjct: 944 -------EDECSELKRDI-------DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Query: 2280 DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLE 2339
L E K L ++ + ++++ L L+ Q+ DL SLE+ K+ + +LE
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
Query: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM------KEQKIISLLSGKEE 2393
R+ E D++ ++ S LE D Q E + E+N EQ + S L K +
Sbjct: 1050 RAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLK 1109
Query: 2394 AIQVAIAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
+Q I EL ++ + E +++L + LS+E EE + E ++A T+ +E K
Sbjct: 1110 ELQARIEELEEELEAERTARAKVEKLRSDLSRELEE---ISERLEEAGGATSVQIEMNKK 1166
Query: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
+ E + + L+ ++LQ++ L ++H + E + I K
Sbjct: 1167 REAEFQKMRRDLEE-----ATLQHEATAAA-----LRKKHADSVAELGEQIDNLQRVKQK 1216
Query: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
L++E + +DD+ S ++ Q+I K + +K ++ Q N+
Sbjct: 1217 LEKEKSEFKLELDDVTS--------------NMEQIIKAKANLEKMCRTLEDQMNEH--- 1259
Query: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR-QVTALQEEGT 2626
K +E++ + DL LQ E +LS++++ + ISQLTR ++T Q+
Sbjct: 1260 -----RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH 2686
L + EEEV +AL + Q + + + +E ++ E + +L++ L
Sbjct: 1315 LK------RQLEEEVKAKNALAHALQSARHDCD-----LLREQYEEETEAKAELQRVLSK 1363
Query: 2687 LHHDAGIMRNETET-AEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN 2745
+ + R + ET A +R EL ++ Q+L + + + A+ S ++ LQN
Sbjct: 1364 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN 1423
Query: 2746 SRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEK 2805
E+++L + S A L ++ R D +L+E E S S LE
Sbjct: 1424 -------EIEDLMVDVERSNAAAAALDKK---QRNFDKILAE----WKQKYEESQSELES 1469
Query: 2806 LNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRS 2865
++ S +L L + E+S +++F + +LQ E L +L K+ ++
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 2866 AAQPSTSPAEVQS-LKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEY 2924
Q E+QS L++A +SL+++ ++L+ Q +I +++ E Q +
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK-- 1587
Query: 2925 QDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHL 2984
++ + +Q L E S L R+K++ +++ + QLSH
Sbjct: 1588 RNHLRVVDSLQTSLDAETRSRNEAL---------------RVKKKMEGDLNEMEIQLSHA 1632
Query: 2985 QNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQK 3044
+ E + Q L Q Q A+ D +N+ + ++L + +
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI------VERRNNLLQAELE 1686
Query: 3045 ELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGP 3104
ELR + S+ L E+ +L +TS+ ++ L+N ++ + +LQ
Sbjct: 1687 ELRAVVEQTERSRKLAEQ-----ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE- 1740
Query: 3105 LNIDVAPGAPQEKNGVHRKSDP---------EELREPQQSFSEAQQQLCNTRQEVNELRK 3155
A QE K+ EEL++ Q + + ++ N Q + +L+
Sbjct: 1741 -----VEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH 1795
Query: 3156 LLEEERDQRVAAENALSVAEEQIRRLE 3182
L+E A + AL ++Q+++LE
Sbjct: 1796 RLDE------AEQIALKGGKKQLQKLE 1816
Score = 158 bits (400), Expect = 7e-38
Identities = 242/1172 (20%), Positives = 502/1172 (42%), Gaps = 196/1172 (16%)
Query: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSA---C 395
++EM + E+F + +A + E+R LE+K + ++EK L +Q L A C
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 396 DAL-----------KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQF---LNRL 441
D L K+ N + L+D+ E + ++LED+ + ++I L ++
Sbjct: 906 DQLIKNKIQLEAKVKEMNER-LEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKV 964
Query: 442 PLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE-LEELKAE 500
++H T ++ + +TEE +A L + + +L EK AL + + L++L+AE
Sbjct: 965 EKEKHATENK----------VKNLTEE-MAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1013
Query: 501 NEKLS----SQITL--------------------LEAQNRTGEADREVSEISIVDIANKR 536
+K++ +++ L LE R E D ++++ SI+D+ N +
Sbjct: 1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Query: 537 SSSAEESGQDVLE----NTFSQKHKEL-SVLLLEMKEAQEEIAFLKLQLQGKRAEEADHE 591
E + E N + + L S L ++KE Q I L+ +L+ +R A E
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 592 VLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEE 651
L +++E ++ LE+ G + + +K +A + R EE
Sbjct: 1134 KLRSDLSRELE-------EISERLEEAGGATSV------QIEMNKKREAEFQKMRRDLEE 1180
Query: 652 ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNL 711
+L K+ D +V ++G+ D L+R+K ++ + + F + N+
Sbjct: 1181 ATLQHEATAAALRKKHAD----SVAELGE-QIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235
Query: 712 DEKAKEISNLNQL-------IEEFKKNADNNSSAFTALSEERDQLLSQVKELS-MVTELR 763
++ K +NL ++ + E + A+ + L+ +R +L ++ ELS + E
Sbjct: 1236 EQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKE 1295
Query: 764 AQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ 823
A + QL + +L Y Q L + L E K+K+ LQ+ D
Sbjct: 1296 ALISQL--------TRGKLTYTQQ------LEDLKRQLEEEVKAKNALAHALQSARHDCD 1341
Query: 824 L---QFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQ 880
L Q+ E++ LQ L SEV + TK +
Sbjct: 1342 LLREQYEEETEAKAELQRVLSKANSEVAQWR------------------------TKYET 1377
Query: 881 LLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSR 940
+++ ++E ++ + ++ Q+ E ++ K L + K L EI+ L + +
Sbjct: 1378 DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1437
Query: 941 AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEE---LQHEFDLLKKENEQRKRKLQA 997
A A ++ +++ + KQ Y+E + S++E L E LK E+ L+
Sbjct: 1438 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1497
Query: 998 ALINRKELLQRVSRLEEELANL------KDESKKEIPLSETE-RGEVEEDKENKEYSE-K 1049
K L + +S L E+L + ++ +K++ + E + +EE + + E+ E K
Sbjct: 1498 FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGK 1557
Query: 1050 CVTSKCQ--EIEIYLKQTISEKEVELQHIRKD-------LEEKLAAEEQFQALVKQMNQT 1100
+ ++ + +I+ +++ ++EK+ E++ +++ L+ L AE + + ++ +
Sbjct: 1558 ILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 1617
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
++ N++++ + + A QK + S +L+K+T + +++
Sbjct: 1618 MEGDLNEMEIQLSHANRMAAEAQKQVKS--------LQSLLKDTQIQLDDAVRAND---- 1665
Query: 1161 ELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFD 1220
+L+E I +E+ LQ +L+E +A++++ + + +EL + + L Q
Sbjct: 1666 DLKENIAIVERRNNLLQAELEEL----RAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1721
Query: 1221 EQSKENENIGDQLRQLQIQVRESI-DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPV 1279
+ + + L QLQ +V E++ + + +++ + + E L K +
Sbjct: 1722 SLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1781
Query: 1280 LESNL---CPDWPSHSEDAS--ALQGGTSVAQ-IKAQLKEIE----------AEKVELEL 1323
++ N+ D ++A AL+GG Q ++A+++E+E AE V+
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMR 1841
Query: 1324 KVSSTTSELTKKSEE----VFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379
K ELT ++EE + +LQ+ ++K L++++ K + EAE A +
Sbjct: 1842 KSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT---------- 1891
Query: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
L R++Q +LDE ++ E V+ L
Sbjct: 1892 ---NLSKFRKVQHELDEAEERADIAESQVNKL 1920
Score = 157 bits (397), Expect = 2e-37
Identities = 253/1282 (19%), Positives = 551/1282 (42%), Gaps = 199/1282 (15%)
Query: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEI-----SIVDIANKRSSSAEESGQDVL 548
LEE++ +E+LS IT ++AQ+R A E ++ S++ I + +
Sbjct: 773 LEEMR--DERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWM 830
Query: 549 ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAP 608
+ F K LL+ E ++E+A +K + + E L++ E ++ E E
Sbjct: 831 KLYFKIKP------LLKSAEREKEMASMKEEFTRLK------EALEKSEARRKELEE--- 875
Query: 609 IKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDG 668
KM L++ D L E A +E+ +++ E + E+ +D
Sbjct: 876 -KMVSLLQEKN-DLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK----EMNERLEDE 929
Query: 669 DKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQE---IYEKNLDEKAKEISNLNQLI 725
++ + + + +DE LK I +LEL K ++ E + +E++ L+++I
Sbjct: 930 EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Query: 726 EEFKKNA----DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRR 781
+ K + + A L E D++ + K +L QV LE +L E E++ R
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAK---VKLEQQVDDLEGSL-EQEKKVR 1045
Query: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ 841
+D E L + K I L+N+ + + ++ + +L ++++
Sbjct: 1046 MDLERAK----------RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095
Query: 842 NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
++++ + ++++ + +++EEL + L + K+++L + R++E + + +EE
Sbjct: 1096 DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE--- 1152
Query: 902 QVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ 961
+ T +++N+++ E + ++ L EEA ++ + ++ K+
Sbjct: 1153 -----AGGATSVQIEMNKKR---EAEFQKMRRDL------EEA---TLQHEATAAALRKK 1195
Query: 962 NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021
+ D ++ G+ + LQ L+KE + K +L N +++++ + LE+ L+D
Sbjct: 1196 HADSVAELGE-QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLED 1254
Query: 1022 E-SKKEIPLSETER--GEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK---EVELQH 1075
+ ++ ET+R ++ + + ++ + E E + Q K +L+
Sbjct: 1255 QMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLED 1314
Query: 1076 IRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQ---AEISENQAIIQKLIT-SNTD 1131
+++ LEE++ A+ + LQ + DLL+ E +E +A +Q++++ +N++
Sbjct: 1315 LKRQLEEEVKAK-------NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 1132 AS------DGDSVALVKETVVISPPCTGSSEHWKPELE---EKILALEKEKEQLQKKLQE 1182
+ + D++ +E + + +E K +LEK K +LQ ++++
Sbjct: 1368 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Query: 1183 ALTS---RKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
+ A +K+R+ + L + K Y Q + + KE ++ +L +L+
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 1240 VRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQ 1299
ES++ T ++E+ L+E + TEQ +
Sbjct: 1488 YEESLEHL--ETFKREN----KNLQEEISDLTEQLGS----------------------- 1518
Query: 1300 GGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTV 1359
G ++ +++ K++EAEK+EL+ + + L + ++ + Q + N+ EIE
Sbjct: 1519 SGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE----- 1573
Query: 1360 SHEAEVHAESLQQKLESSQLQIAGLEHLR---ELQPKLD-------ELQKLISKKEEDVS 1409
L +K E +++ A HLR LQ LD E ++ K E D++
Sbjct: 1574 --------RKLAEKDE--EMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623
Query: 1410 YLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE----------RIKQLQV 1459
+ QLS + Q ++ + L+K QL+ + +D+ R LQ
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683
Query: 1460 ELCEMK------QKPEEIGE----ESRAKQQIQRKLQAALISRKEALKENKS-----LQE 1504
EL E++ ++ ++ E E+ + Q+ +LI++K+ + + S ++E
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEE 1743
Query: 1505 ELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS 1564
+ R E+ K++ D KE+DT L +++ ++ I ++ L E +
Sbjct: 1744 AVQECRNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKNMEQTIKDLQHRLDEAE- 1801
Query: 1565 LSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE----YEILLQ 1620
++AL+G + +KL + L++ AE E K ++K E+ Q
Sbjct: 1802 --------QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ 1853
Query: 1621 SYENVSN------EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674
+ E+ N +++Q V+A +++ +E + + + ++ + +L EAE+ +
Sbjct: 1854 TEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIA 1913
Query: 1675 KEKMRKF-AKSKQQKILELEEE 1695
+ ++ K AKS+ L EE
Sbjct: 1914 ESQVNKLRAKSRDIGTKGLNEE 1935
Score = 143 bits (360), Expect = 3e-33
Identities = 229/1135 (20%), Positives = 490/1135 (43%), Gaps = 137/1135 (12%)
Query: 64 LKDIIRQKDV-QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVL 122
LK R+K++ ++++ L+E + ++ + K+L+ K+ SL + +++ Q
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELE----EKMVSLLQEKNDLQLQVQAEQ 895
Query: 123 PTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEM 182
+EE+ + K+ + E +++++ +L+++EE+ + L A+ + + ++ ++ ++
Sbjct: 896 DNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKRDI 954
Query: 183 EEFVMMKQQLQEKEEFISTLQAQLSQTQA--EQAAQQVVREKDARFETQVRL-----HED 235
++ + ++++++ L++ A ++ ++ +EK A E + E+
Sbjct: 955 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEE 1014
Query: 236 ELLQLVTQADVETEMQ--------QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQ 287
+ + +T+A V+ E Q ++ + ++ LE + L G + L Q+ + E
Sbjct: 1015 DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD---LKLTQESIMDLEN 1071
Query: 288 RNQILSQQLQQMEAEHNTLRNTVETER----------EESKILLEKMELEV-AER----- 331
Q L ++L++ + E N L +E E+ +E + +E++E E+ AER
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAK 1131
Query: 332 --KLSFHNLQEEMHHLLEQFEQAGQA---QAELESRYSALEQKHKAEMEEKT-------- 378
KL +L E+ + E+ E+AG A Q E+ + A QK + ++EE T
Sbjct: 1132 VEKLR-SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190
Query: 379 ----SHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEI 434
H S+ + G+++ D L+ KL ++K+E ++ +E ++ K+ +
Sbjct: 1191 ALRKKHADSVAELGEQI----DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA-NL 1245
Query: 435 SQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIEL 494
+ L Q +E S+ T+ ++ L + +L+ E G EL
Sbjct: 1246 EKMCRTLEDQMNEHRSKAE-----------ETQRSVNDLTSQRAKLQTENG-------EL 1287
Query: 495 EELKAENEKLSSQIT--LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTF 552
E E L SQ+T L + + R++ E A + + D+L +
Sbjct: 1288 SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347
Query: 553 SQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMK 612
++ + + L + +A E+A Q + K +A + +E K+ K+
Sbjct: 1348 EEETEAKAELQRVLSKANSEVA----QWRTKYETDAIQRTEELEEAKK---------KLA 1394
Query: 613 VFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSL 672
L++ + + + SSL K + E + + N A L +++ DK L
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKT-KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1453
Query: 673 SAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEK---AKEISNLNQLIEEFK 729
+ + Q ELE + + L K + YE++L+ +E NL + I +
Sbjct: 1454 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1513
Query: 730 KNADNNSSAFTALSEERDQLLSQVKEL-SMVTELRAQVK---------QLEMNLAEAERQ 779
+ ++ L + R QL ++ EL S + E A ++ QLE N +AE +
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1573
Query: 780 RRL---DYESQTA---HDNLLTEQIHSLSIEAKSKDVKIEV---LQNELDDVQLQFS--- 827
R+L D E + A H ++ SL E +S++ + V ++ +L+++++Q S
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 828 ----EQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883
E ++SLQS L++ + ++ + + + + + + + E+ ++ ++
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEE 943
+ +R + +Q + E ++V + T + Q + L ++E + AEE
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
Query: 944 AKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRK 1003
K+ + + ++ LK+ D + ++ K Q DL + +E + L+ +
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ 1813
Query: 1004 ELLQRVSRLEEEL-ANLKDESKKEIPLSETERG------EVEEDKENKEYSEKCVTSKCQ 1056
+L RV LE EL A K ++ + ++ER + EED++N + V
Sbjct: 1814 KLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL 1873
Query: 1057 EIEIYLKQTISEKE---VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQI 1108
+++ Y +Q +E L RK E AEE+ Q+N+ L+ K+ I
Sbjct: 1874 KVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK-LRAKSRDI 1927
Score = 138 bits (348), Expect = 8e-32
Identities = 202/1015 (19%), Positives = 423/1015 (41%), Gaps = 166/1015 (16%)
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
KEE RLKE ++ K + R+ + EE +++ + ++D Q+ Q + ++ CD
Sbjct: 853 KEEFTRLKE---ALEKSEARRKEL--EEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907
Query: 2282 L-------QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQ 2334
L + + KE+ +LE+ + + KLE E LK + DL +L K +++
Sbjct: 908 LIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKE 967
Query: 2335 KGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEA 2394
K E ++ ++ +L + +A +E + +++ +E K+ +L K
Sbjct: 968 KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAK--- 1024
Query: 2395 IQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454
+L QQ D +LE L QE++ + LE +K E++ ++ +
Sbjct: 1025 -----VKLEQQVD----DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND--- 1072
Query: 2455 QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRG 2514
K QLD +K N + + D Q L + L+K ++E A +L+EE+
Sbjct: 1073 -KQQLDERLKKKDFELNALNARIEDEQALGSQ-----LQKK--LKELQARIEELEEELEA 1124
Query: 2515 LRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE 2574
R+ + + L EL + E L + VQ++ NK+ E ++ K+
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEA--------GGATSVQIEMNKKREAEFQKMRR 1176
Query: 2575 KLKESEEANE---------------DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVT 2619
L+E+ +E +L + LQ KQ L KE K+ + +T +
Sbjct: 1177 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Query: 2620 ALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDK 2679
+ +K K ++ +K LE+++ + +A + + D
Sbjct: 1237 QI------------IKAK-----------ANLEKMCRTLEDQMNEHRSKAEETQRSVNDL 1273
Query: 2680 LKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRS 2739
+ K L + G + + + E +++L R + Q+L + L Q++ ++
Sbjct: 1274 TSQRAK-LQTENGELSRQLDEKEALISQLTRGKLTYTQQL-------EDLKRQLEEEVKA 1325
Query: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS 2799
++L ++ A + D L+ +Y+ + A+L Q +L++ SE A E ++
Sbjct: 1326 KNALAHALQSARHDCDLLREQYEEETEAKAEL--QRVLSKAN----SEVAQWRTKYETDA 1379
Query: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE 2859
+ E+L +E L+ +L+++ V++ + +SL+ + L NE+E
Sbjct: 1380 IQRTEEL-------EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432
Query: 2860 EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKA 2919
E RS A + + ++ K ++ + + EL++ Q++ ++ TEL LK
Sbjct: 1433 E---RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS---TELFKLKN 1486
Query: 2920 QLQEYQDKTKAFQIMQEELRQENLSWQHEL-------HQLRMEKSSWEIHERRMKEQYLM 2972
+E + + F+ + L++E +L H+L EK ++ +M+ Q
Sbjct: 1487 AYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHEL--EKVRKQLEAEKMELQ--S 1542
Query: 2973 AISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRT 3032
A+ + + L H + I + +Q +K + +R+ + + +N + + L+T
Sbjct: 1543 ALEEAEASLEHEEGKILRAQLEFNQ---IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Query: 3033 QL-------NDSLK-------EIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRE 3078
L N++L+ ++++ E+++ N ++ ++ +L L DT L +
Sbjct: 1600 SLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD 1659
Query: 3079 NQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELR----EPQQ 3134
+ DL + A++E++ LQA + EELR + ++
Sbjct: 1660 AVRANDDLKENIAIVERRNNLLQA----------------------ELEELRAVVEQTER 1697
Query: 3135 SFSEAQQQLCNTRQEVNELR----KLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185
S A+Q+L T + V L L+ +++ + EE ++ ++E
Sbjct: 1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAE 1752
Score = 122 bits (307), Expect = 4e-27
Identities = 192/923 (20%), Positives = 387/923 (41%), Gaps = 143/923 (15%)
Query: 31 DPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAAD 90
D +L QES M+ N Q+ L + +++KD +L + +++E+
Sbjct: 1058 DLKLTQESIMDLENDKQQ---------------LDERLKKKDFELNALNARIEDEQALGS 1102
Query: 91 NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIK 150
KKLK L IEE+ EE+L ++ ++EK++
Sbjct: 1103 QLQKKLK--------ELQARIEEL--------------EEEL----EAERTARAKVEKLR 1136
Query: 151 HKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ 210
L + E IS + A + Q + EF M++ L+E A L +
Sbjct: 1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196
Query: 211 AEQAAQ--------QVVREKDARFETQVRLHEDELLQLVTQ-ADVETEMQQKLRVLQRKL 261
A+ A+ Q V++K + +++ +L D++ + Q + +++ R L+ ++
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321
EH + V+ L + + N LS+QL + EA + L T ++ + L
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316
Query: 322 EKMELEVAERKLSFHNLQEEMHH---LLEQFEQAGQAQAELE-------SRYSALEQKHK 371
++E EV + H LQ H L EQ+E+ +A+AEL+ S + K++
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 372 AEMEEKTSHI-LSLQKTGQELQSACDALKDQNSKLLQ-DKNEQAVQSAQTIQQLEDQL-- 427
+ ++T + + +K Q LQ A +A++ N+K +K + +Q+ ++ED +
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN-----EIEDLMVD 1431
Query: 428 QQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE--ENIASLQKRVVELENE-- 483
++S + L++ Q +F + E Q E + S QK L E
Sbjct: 1432 VERSNAAAAALDK---------KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF 1482
Query: 484 --KGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541
K A S LE K EN+ L +I+ L Q G + + + E+ V K+ + +
Sbjct: 1483 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQ--LGSSGKTIHELEKV---RKQLEAEK 1537
Query: 542 ESGQDVLENT-FSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADH---------E 591
Q LE S +H+E +L AQ E +K +++ K AE+ +
Sbjct: 1538 MELQSALEEAEASLEHEEGKIL-----RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLR 1592
Query: 592 VLD--QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTS 649
V+D Q + +++K +E + + + + + A ++Q +
Sbjct: 1593 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 650 EEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEK 709
+I L+DA D ++++ V Q ELE L++ + + E +++++ E+
Sbjct: 1653 TQIQLDDA----VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE----RSRKLAEQ 1704
Query: 710 NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQL 769
L E ++ + L+ S T+L ++ ++ + + +L E Q
Sbjct: 1705 ELIETSERVQLLH--------------SQNTSLINQKKKMDADLSQLQTEVEEAVQ---- 1746
Query: 770 EMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVK--IEVLQNELDDVQ---- 823
E AE E+ ++ ++ + L EQ S +E K+++ I+ LQ+ LD+ +
Sbjct: 1747 ECRNAE-EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1805
Query: 824 ----LQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMD 879
Q + +R L+++L+ ++ E + +R +++EL+ + + ++
Sbjct: 1806 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 880 QLLLEKKRDVETLQQTIEEKDQQ 902
L+ + + V+ ++ EE ++Q
Sbjct: 1866 DLVDKLQLKVKAYKRQAEEAEEQ 1888
Score = 75.9 bits (185), Expect = 6e-13
Identities = 122/565 (21%), Positives = 223/565 (39%), Gaps = 94/565 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKL 96
E+D E+ +++LA Q E + + K L++ LQ E + +++
Sbjct: 1376 ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERS 1435
Query: 97 KLHAKA---KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
A A K + +K + E K + +S+ +L K + E+ K+K+
Sbjct: 1436 NAAAAALDKKQRNFDKILAEWKQK-------YEESQSELESSQKEARSLSTELFKLKNAY 1488
Query: 154 QEKEELISTLQAQLTQAQ------AEQPAQSSTEMEEFVMMKQQLQ-EKEEFISTLQ--- 203
+E E + T + + Q EQ S + E +++QL+ EK E S L+
Sbjct: 1489 EESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAE 1548
Query: 204 ------------AQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVET--- 248
AQL Q + ++ + EKD E R H + L T D ET
Sbjct: 1549 ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSR 1608
Query: 249 -----------------------------EMQQKLRVLQRKLEEHEESLVGRAQVVDLLQ 279
E Q++++ LQ L++ + L + D L+
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668
Query: 280 QELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQ 339
+ + E+RN +L +L+++ A V + E S+ L E+ +E +ER H+
Sbjct: 1669 ENIAIVERRNNLLQAELEELRA--------VVEQTERSRKLAEQELIETSERVQLLHSQN 1720
Query: 340 EEMHHLLEQFE-QAGQAQAELESRYSA---LEQKHKAEMEEKTSHILSLQKTGQELQSAC 395
+ + ++ + Q Q E+E E+K K + + L+K Q+ +
Sbjct: 1721 TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE-QDTSAHL 1779
Query: 396 DALK---DQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQT 452
+ +K +Q K LQ + ++A Q A ++ + QLQ+ + + N L +Q A
Sbjct: 1780 ERMKKNMEQTIKDLQHRLDEAEQIA--LKGGKKQLQKLEARVRELENELEAEQKRNAESV 1837
Query: 453 SFPDVYNEGTQAVT------EENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSS 506
+ +T +N+ LQ V +L+ + A + E EE N LS
Sbjct: 1838 KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEE--QANTNLSK 1895
Query: 507 ----QITLLEAQNRTGEADREVSEI 527
Q L EA+ R A+ +V+++
Sbjct: 1896 FRKVQHELDEAEERADIAESQVNKL 1920
Score = 36.2 bits (82), Expect = 0.55
Identities = 29/158 (18%), Positives = 75/158 (47%), Gaps = 9/158 (5%)
Query: 24 QNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVE-LKDIIRQKDVQLQQKDEAL 82
+ ++ D H E + T +D+Q RL AEQ+ ++ K +++ + ++++ + L
Sbjct: 1767 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENEL 1826
Query: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
+ E+K +K ++ ++ ++ L EE + + + + ++ + + + E
Sbjct: 1827 EAEQKRNAESVKGMR-KSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEA 1885
Query: 143 E-------MEIEKIKHKLQEKEELISTLQAQLTQAQAE 173
E + K++H+L E EE ++Q+ + +A+
Sbjct: 1886 EEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923
Score = 32.7 bits (73), Expect = 6.0
Identities = 46/263 (17%), Positives = 106/263 (40%), Gaps = 42/263 (15%)
Query: 2954 MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPET 3013
M +W + K + L+ ++++++++ ++ L+ + +++ + + + +
Sbjct: 822 MGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMV--- 878
Query: 3014 SASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTS 3073
+L+ E L+ Q+ + E R QL N QL + ++ +L D
Sbjct: 879 --------SLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEE 930
Query: 3074 QSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEK--NGVHRKSDPEE--- 3128
+ E L + C+ L++ + +L+ ++ A + K N + +E
Sbjct: 931 EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 990
Query: 3129 -LREPQQSFSEAQQQLCNT------------------RQEVNELRKLLEEERDQRVAAEN 3169
L + +++ EA QQ + Q+V++L LE+E+ R+ E
Sbjct: 991 KLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLER 1050
Query: 3170 A-------LSVAEEQIRRLEHSE 3185
A L + +E I LE+ +
Sbjct: 1051 AKRKLEGDLKLTQESIMDLENDK 1073
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 966 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1080
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1199
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1316
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1366
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1367 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1404
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1461
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1516 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1565
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1566 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1604
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1605 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1658
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1659 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1763
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1764 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1816
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1817 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 1871
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 1872 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 1982
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2159
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2160 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2328
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2329 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2436
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2492
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2667
Query: 2631 HAQ 2633
Q
Sbjct: 2668 ELQ 2670
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1044
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1045 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1089
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1090 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1149
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1329
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1384
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1385 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1443 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1499
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1618 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1677 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1722
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1843 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 1892
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 1893 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 1944 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2052
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2053 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2098
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2154
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2332
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2393 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2443
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2502
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2503 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2555
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2556 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2613 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2644
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 193 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 248
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 249 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 304
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 305 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 361 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 419
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 420 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 480 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 520
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 521 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 574
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 575 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 633
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 634 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 694 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 730
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 731 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 790
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 791 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 846
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 895
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 896 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 945
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 946 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1005
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 1006 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1062
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1063 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1296
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1297 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1345
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1346 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1400
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1521 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1569
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1623
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1624 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1683 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1734
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1735 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1841
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1842 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 1893
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 1954 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 2010
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 2011 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2050
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2051 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2162
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2341
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2522 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2565
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2566 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2620
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1152 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1198
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1199 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1255
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1256 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1311
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1372 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1431 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1481
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1539
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1540 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1574
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1575 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1628
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1672
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1673 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1724
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1777
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 1999
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2178 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2224
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2345 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2400
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2581 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2638 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 420
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 421 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 475
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 476 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 533
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 534 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 584
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 585 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 637
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 818 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 876
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 877 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 936
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 937 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 991
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 992 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1039
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1040 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1095
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1096 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1145
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1146 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1201
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1202 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1239
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1240 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1410
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1411 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1438
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1542
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1543 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1590 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1646 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1694
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1695 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1797
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1798 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRR 2109
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1751 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 1982 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2035
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2147
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2247
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2301
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2362 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2419
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2420 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2468 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2511
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2632 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 970 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1028
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1084
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1085 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1144
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1145 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1203
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1204 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1263
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1264 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1320
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1321 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1370
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1371 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1408
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1465
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1520 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1569
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1570 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1608
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1609 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1662
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1663 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1767
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1768 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1820
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1821 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 1875
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 1876 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 1986
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2047 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2163
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2164 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2220
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2332
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2333 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2440
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2496
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2556
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2612
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2613 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2671
Query: 2631 HAQ 2633
Q
Sbjct: 2672 ELQ 2674
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 991 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1048
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1049 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1093
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1094 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1153
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1154 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1213
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1214 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1273
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1274 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1333
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1334 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1388
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1389 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1447 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1503
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1563
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1564 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1622 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1680
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1681 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1726
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1727 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1847 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 1896
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 1897 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 1948 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2001
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2056
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2057 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2102
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2158
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2159 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2217
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2218 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2277
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2336
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2397 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2447
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2448 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2506
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2507 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2559
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2560 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2616
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2617 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2648
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 197 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 252
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 253 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 308
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 309 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 364
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 365 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 423
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 424 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 483
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 484 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 524
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 525 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 578
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 579 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 637
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 638 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 697
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 698 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 734
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 735 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 794
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 795 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 850
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 851 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 899
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 900 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 949
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 950 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1009
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 1010 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1066
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1067 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1126
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1127 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1186
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1187 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1246
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1300
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1301 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1349
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1350 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1404
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1525 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1573
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1627
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1628 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1687 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1738
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1739 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1845
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1846 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 1897
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 1898 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1957
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 1958 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 2014
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 2015 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2054
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2055 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2166
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2345
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2405
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2406 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2465
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2525
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2526 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2569
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2570 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2624
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1156 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1202
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1203 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1259
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1260 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1315
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1316 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1375
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1376 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1435 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1485
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1486 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1543
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1544 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1578
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1579 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1632
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1676
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1677 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1728
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1781
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 1900
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1960
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 2003
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2121
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2122 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2181
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2182 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2228
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2349 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2404
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2585 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2641
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2642 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2685
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 368 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 424
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 425 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 479
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 480 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 537
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 538 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 588
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 589 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 641
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 642 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 702 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 762 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 822 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 880
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 881 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 940
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 941 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 995
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 996 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1043
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1044 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1099
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1100 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1149
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1150 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1205
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1206 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1243
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1244 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1300
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1360
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1414
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1415 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1442
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1443 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1502
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1546
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1547 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1593
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1594 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1650 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1698
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1699 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1801
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1802 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRR 2113
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1755 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1925
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 1926 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1985
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 1986 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2039
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2096
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2151
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2152 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2251
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2252 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2305
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2365
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2366 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2423
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2424 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2471
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2472 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2515
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2516 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2575
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2576 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2635
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2636 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2691
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 966 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1080
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1081 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1141 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1199
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1316
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1366
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1367 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1404
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1461
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1516 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1565
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1566 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1604
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1605 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1658
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1659 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1763
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1764 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1816
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1817 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 1871
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 1872 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 1982
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2043 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2159
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2160 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2216
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2328
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2329 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2436
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2492
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2552
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2609 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2667
Query: 2631 HAQ 2633
Q
Sbjct: 2668 ELQ 2670
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1044
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1045 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1089
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1090 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1149
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1329
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1384
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1385 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1443 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1499
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1618 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1676
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1677 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1722
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1843 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 1892
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 1893 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 1944 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1997
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2052
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2053 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2098
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2154
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2155 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2273
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2332
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2393 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2443
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2502
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2503 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2555
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2556 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2613 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2644
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 193 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 248
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 249 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 304
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 305 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 360
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 361 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 419
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 420 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 479
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 480 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 520
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 521 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 574
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 575 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 633
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 634 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 694 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 730
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 731 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 790
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 791 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 846
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 895
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 896 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 945
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 946 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1005
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 1006 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1062
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1063 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1183 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1242
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1296
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1297 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1345
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1346 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1400
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1521 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1569
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1623
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1624 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1683 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1734
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1735 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1841
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1842 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 1893
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 1954 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 2010
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 2011 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2050
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2051 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2162
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2341
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2401
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2402 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2522 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2565
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2566 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2620
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1152 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1198
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1199 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1255
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1256 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1311
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1371
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1372 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1431 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1481
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1539
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1540 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1574
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1575 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1628
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1672
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1673 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1724
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1777
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 1999
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2117
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2118 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2177
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2178 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2224
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2345 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2400
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2581 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2638 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 420
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 421 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 475
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 476 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 533
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 534 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 584
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 585 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 637
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 818 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 876
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 877 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 936
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 937 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 991
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 992 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1039
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1040 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1095
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1096 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1145
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1146 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1201
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1202 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1239
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1240 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1410
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1411 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1438
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1542
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1543 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1590 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1646 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1694
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1695 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1797
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1798 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRR 2109
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1751 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 1982 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2035
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2147
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2247
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2301
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2362 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2419
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2420 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2467
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2468 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2511
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2632 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 934 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 992
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 993 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1048
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1049 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1108
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1109 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1167
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1168 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1227
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1228 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1284
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1285 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1334
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1335 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1372
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1429
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1484 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1533
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1534 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1572
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1573 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1626
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1627 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1731
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1732 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1784
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1785 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 1839
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 1840 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 1950
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2011 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2127
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2128 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2184
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2244
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2296
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2297 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2404
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2460
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2520
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2576
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2577 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2635
Query: 2631 HAQ 2633
Q
Sbjct: 2636 ELQ 2638
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 955 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1012
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1013 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1057
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1058 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1117
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1118 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1177
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1178 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1237
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1238 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1297
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1298 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1352
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1353 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1411 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1467
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1468 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1527
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1528 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1586 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1644
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1645 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1690
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1691 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1811 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 1860
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 1861 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 1911
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 1912 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1965
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2020
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2021 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2066
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2122
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2123 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2181
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2182 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2241
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2300
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2361 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2411
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2412 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2470
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2471 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2523
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2524 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2580
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2581 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2612
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 161 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 216
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 217 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 272
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 273 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 328
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 329 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 387
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 388 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 447
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 448 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 488
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 489 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 542
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 543 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 601
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 602 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 661
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 662 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 698
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 699 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 758
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 759 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 814
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 815 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 863
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 864 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 913
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 914 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 973
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 974 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1030
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1031 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1090
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1210
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1264
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1265 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1313
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1314 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1368
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1489 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1537
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1591
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1592 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1650
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1651 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1702
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1703 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1809
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1810 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 1861
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 1862 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1921
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 1922 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 1978
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 1979 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2018
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2019 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2130
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2309
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2369
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2370 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2429
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2489
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2490 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2533
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2534 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2588
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1120 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1166
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1167 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1223
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1224 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1279
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1280 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1339
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1340 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1399 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1449
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1450 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1507
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1508 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1542
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1543 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1596
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1640
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1641 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1692
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1745
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 1864
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1924
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 1967
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2085
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2086 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2145
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2146 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2192
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2313 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2368
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2549 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2605
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2606 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2649
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 332 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 388
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 389 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 443
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 444 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 501
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 502 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 552
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 553 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 605
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 606 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 666 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 726 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 786 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 844
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 845 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 904
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 905 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 959
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 960 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1007
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1008 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1063
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1064 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1113
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1114 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1169
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1170 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1207
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1208 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1264
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1324
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1378
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1379 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1406
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1407 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1466
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1510
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1511 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1557
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1558 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1614 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1662
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1663 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1765
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1766 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRR 2077
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1719 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1889
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 1890 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1949
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 1950 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2003
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2060
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2115
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2116 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2215
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2216 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2269
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2329
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2330 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2387
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2388 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2435
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2436 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2479
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2480 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2539
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2540 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2599
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2600 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2655
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 1103 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1161
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1217
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1218 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1277
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1278 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1336
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1337 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1396
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1397 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1453
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1454 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1503
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1504 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1541
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1598
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1653 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1702
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1703 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1741
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1742 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1795
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1796 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1900
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1901 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1953
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1954 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 2008
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 2009 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 2119
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2296
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2297 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2353
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2413
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2465
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2466 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2573
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2629
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2689
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2745
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2746 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2804
Query: 2631 HAQ 2633
Q
Sbjct: 2805 ELQ 2807
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 1124 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1181
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1182 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1226
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1227 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1286
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1287 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1346
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1347 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1406
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1407 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1466
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1467 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1521
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1522 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1580 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1636
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1696
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1697 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1755 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1814 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1859
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1860 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1980 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 2029
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 2030 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 2080
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 2081 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2189
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2190 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2235
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2291
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2292 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2350
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2351 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2410
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2469
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2530 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2580
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2639
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2640 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2692
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2693 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2749
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2750 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2781
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 330 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 385
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 386 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 441
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 442 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 497
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 498 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 556
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 557 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 616
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 617 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 657
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 658 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 711
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 712 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 770
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 771 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 830
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 831 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 867
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 868 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 927
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 928 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 983
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 984 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 1032
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 1033 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 1082
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 1083 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1142
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 1143 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1199
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1200 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1259
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1260 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1319
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1320 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1379
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1433
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1434 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1482
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1483 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1537
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1658 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1706
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1760
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1761 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1819
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1820 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1871
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1872 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1978
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1979 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 2030
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 2031 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 2091 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 2147
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 2148 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2187
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2188 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2299
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2478
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2538
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2539 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2598
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2658
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2659 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2702
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2703 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2757
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1289 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1335
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1336 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1392
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1393 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1448
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1449 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1508
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1509 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1568 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1618
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1619 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1676
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1677 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1711
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1712 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1765
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1809
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1810 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1861
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1914
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 2033
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 2093
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 2136
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2254
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2255 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2314
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2315 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2361
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2482 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2537
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2718 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2818
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 557
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 558 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 612
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 613 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 670
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 671 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 721
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 722 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 774
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 955 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 1013
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 1014 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 1073
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 1074 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 1128
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 1129 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1176
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1177 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1232
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1233 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1282
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1283 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1338
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1339 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1376
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1377 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1433
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1547
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1548 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1575
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1576 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1635
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1679
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1680 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1726
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1727 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1783 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1831
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1832 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1934
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1935 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRR 2246
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1888 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 2058
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 2059 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2118
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 2119 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2172
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2229
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2284
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2285 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2384
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2385 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2438
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2498
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2499 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2556
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2557 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2604
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2605 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2648
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2649 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2708
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2709 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2768
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2769 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2824
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 944 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1002
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1058
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1059 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1118
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1119 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1177
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1178 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1237
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1238 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1294
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1295 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1344
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1345 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1382
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1439
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1494 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1543
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1544 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1582
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1583 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1636
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1637 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1741
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1742 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1794
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1795 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 1849
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 1850 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 1960
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2137
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2138 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2194
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2254
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2306
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2307 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2414
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2470
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2530
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2586
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2587 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2645
Query: 2631 HAQ 2633
Q
Sbjct: 2646 ELQ 2648
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 965 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1022
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1023 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1067
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1068 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1127
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1128 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1187
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1188 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1247
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1248 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1307
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1308 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1362
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1363 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1421 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1477
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1537
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1538 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1596 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1655 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1700
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1701 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1821 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 1870
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 1871 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 1921
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 1922 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2030
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2031 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2076
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2132
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2133 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2191
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2192 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2251
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2310
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2371 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2421
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2422 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2480
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2481 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2533
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2534 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2590
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2591 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2622
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 171 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 226
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 227 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 282
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 283 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 338
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 339 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 397
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 398 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 457
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 458 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 498
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 499 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 552
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 553 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 611
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 612 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 671
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 672 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 708
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 709 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 768
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 769 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 824
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 825 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 873
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 874 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 923
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 924 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 983
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 984 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1040
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1041 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1100
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1101 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1160
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1161 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1220
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1274
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1275 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1323
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1324 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1378
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1499 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1547
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1601
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1602 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1661 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1712
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1713 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1819
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1820 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 1871
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 1932 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 1988
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 1989 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2028
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2029 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2140
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2319
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2379
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2380 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2439
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2499
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2500 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2543
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2544 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2598
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1130 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1176
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1177 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1233
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1234 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1289
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1290 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1349
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1350 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1409 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1459
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1460 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1517
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1518 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1552
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1553 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1606
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1650
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1651 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1702
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1755
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 1874
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 1977
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2095
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2096 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2155
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2156 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2202
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2323 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2378
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2558
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2559 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2659
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 342 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 398
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 399 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 453
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 454 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 511
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 512 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 562
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 563 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 615
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 616 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 676 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 736 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 796 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 854
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 855 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 914
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 915 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 969
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 970 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1017
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1018 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1073
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1074 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1123
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1124 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1179
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1180 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1217
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1218 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1388
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1389 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1416
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1417 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1476
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1520
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1521 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1567
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1568 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1624 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1672
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1673 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1775
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1776 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRR 2087
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1729 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1840 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1899
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 1900 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1959
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 1960 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2013
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2070
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2071 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2125
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2126 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2225
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2226 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2279
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2280 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2339
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2340 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2397
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2398 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2445
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2446 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2489
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2490 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2549
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2550 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2609
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2610 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2665
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 952 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1010
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1066
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1067 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1126
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1127 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1185
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1186 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1245
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1246 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1302
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1303 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1352
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1353 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1390
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1447
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1502 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1551
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1552 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1590
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1591 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1644
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1645 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1749
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1750 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1802
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1803 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 1857
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 1858 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 1968
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2029 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2145
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2146 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2202
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2262
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2314
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2315 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2422
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2478
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2538
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2594
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2595 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2653
Query: 2631 HAQ 2633
Q
Sbjct: 2654 ELQ 2656
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 973 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1030
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1031 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1075
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1076 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1135
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1136 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1195
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1196 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1255
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1256 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1315
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1316 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1370
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1371 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1429 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1485
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1486 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1545
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1546 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1604 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1662
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1663 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1708
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1709 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1769 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1828
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1829 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 1878
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 1879 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 1929
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 1930 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1983
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2038
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2039 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2084
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2140
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2141 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2199
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2200 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2259
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2318
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2379 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2429
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2430 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2488
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2489 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2541
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2542 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2598
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2599 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2630
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 179 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 234
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 235 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 290
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 291 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 346
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 347 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 405
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 406 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 465
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 466 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 506
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 507 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 560
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 561 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 619
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 620 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 679
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 680 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 716
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 717 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 776
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 777 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 832
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 833 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 881
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 882 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 931
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 932 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 991
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 992 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1048
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1049 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1108
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1109 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1168
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1169 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1228
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1282
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1283 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1331
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1332 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1386
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1507 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1555
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1609
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1610 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1668
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1669 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1720
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1721 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1827
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1828 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 1879
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 1880 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1939
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 1940 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 1996
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 1997 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2036
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2037 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2092
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2148
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2327
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2387
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2388 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2447
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2507
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2508 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2551
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2552 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2606
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1138 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1184
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1185 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1241
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1242 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1297
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1298 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1357
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1358 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1417 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1467
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1468 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1525
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1526 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1560
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1561 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1614
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1658
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1659 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1710
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1763
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1824 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 1882
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1942
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 1985
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2103
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2104 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2163
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2164 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2210
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2331 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2386
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2566
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2567 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2623
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2624 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2667
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 350 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 406
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 407 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 461
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 462 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 519
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 520 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 570
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 571 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 623
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 624 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 684 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 744 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 804 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 862
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 863 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 922
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 923 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 977
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 978 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1025
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1026 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1081
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1082 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1131
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1132 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1187
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1188 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1225
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1226 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1282
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1396
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1397 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1424
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1425 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1484
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1528
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1529 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1575
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1576 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1632 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1680
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1681 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1783
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1784 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRR 2095
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1737 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1848 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1907
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 1908 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1967
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 1968 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2021
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2078
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2079 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2133
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2134 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2233
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2234 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2287
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2288 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2347
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2348 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2405
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2406 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2453
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2454 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2497
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2498 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2557
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2558 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2617
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2618 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2673
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 214 bits (546), Expect = 9e-55
Identities = 383/1863 (20%), Positives = 772/1863 (41%), Gaps = 224/1863 (12%)
Query: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTI 896
Q LQ+ E E + R + S+++++ L E +L L+K+ E Q+
Sbjct: 993 QQLLQSLEQGAQEES-RCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1051
Query: 897 EEKDQQVTEISFSMTEKMVQLNEEKFSLGVE----IKTLKEQLNLLSRAEEAKKEQVEED 952
E++ Q + EK E TL+ +L L K EQV
Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL----GKLEQVRSL 1107
Query: 953 NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR--KLQAALINRKELLQRVS 1010
+ + + + Q ++E L+ + LK+ +L+A + K+L +
Sbjct: 1108 SAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1167
Query: 1011 RLEEELANLKDESKKEIPLSET-ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQT-ISE 1068
+ L+DE + + E ++ E D E + + E+ V + + L QT + +
Sbjct: 1168 AQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER-VAQLLERWQAVLAQTDVRQ 1226
Query: 1069 KEVE-----LQHIRKD-------LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEIS 1116
+E+E L++ R+ L++ +EQ QA+ +Q ++++ Q L EI
Sbjct: 1227 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1286
Query: 1117 ENQAII---QKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK 1173
+ + Q+ +A + LV + P + + KP+++ ++ +E
Sbjct: 1287 RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK---KPKVQSGSESVIQEY 1343
Query: 1174 EQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQL 1233
L+ E T +K E R + EE RL EQ ++++E E + +
Sbjct: 1344 VDLRTHYSELTTLTSQYIKFISETLRRMEEE--------ERLAEQ--QRAEERERLAEVE 1393
Query: 1234 RQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSE 1293
L+ Q R+ + + Q E + K +Q + V+
Sbjct: 1394 AALEKQ-RQLAEAHAQAKAQAEREA----------KELQQRMQEEVVR-----------R 1431
Query: 1294 DASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
+ +A+ I+ +L+++ + E E++ + +E ++S +++E+I L++
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKARQAEAAERSR--LRIEEEIRVVRLQL 1488
Query: 1354 ESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS-----KKEEDV 1408
E+ + AE ++L+ + E ++ Q R+ Q + + L++ + K++ +V
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQ------KRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 1409 SYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKP 1468
S +E EAA E++ ++AL +L +QA+E + R++Q +VE Q
Sbjct: 1543 ELASRVKAEAEAAR--------EKQRALQALE-ELRLQAEEAERRLRQAEVERARQVQV- 1592
Query: 1469 EEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVS 1528
A + QR +A L S++ + E + +L +SL + V+
Sbjct: 1593 --------ALETAQRSAEAELQSKRASFAEKTA-------------QLERSLQEEHVAVA 1631
Query: 1529 AQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
+E + R A Q E ++ E +R L E L ++ E+L+L L+ ++K +
Sbjct: 1632 QLREEAE----RRAQQQAEAERAREEAEREL-ERWQLKAN-EALRLRLQAEEVAQQKSLA 1685
Query: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
+ E+ K + AE + + K E ++ E E E+ + + E Q++
Sbjct: 1686 QAEAEKQKEEAE-----REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
+L A ++ E+Q Q E+E+ ++ + A + QK ELE E ++RAE
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQRE----AAAATQKRQELEAELAKVRAE------ 1790
Query: 1709 TAKECMETLLSSNASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
ME LL+S A +EE E+ K E + +F+ L E L ++ K Q
Sbjct: 1791 -----MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-- 1843
Query: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
+ A +A + V E +I T + ++ + +E+ + A
Sbjct: 1844 ---RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE-- 1898
Query: 1825 VSKDFSSHDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQTLENEKNTL---LSQISTK 1880
DE + +Q + A +EE Q K LE +K + L Q
Sbjct: 1899 --------DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNY 1940
+ E+ L+ K +++ EL R+ E K+ E Q +L
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ-RQLAAEEERR 2009
Query: 1941 CQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK- 1999
++ + K+ E E +K E E + V+E ++ +E ++Q AQ+
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
Query: 2000 -----EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
+ K+HA +Q+ +E QQ ++Q Q + + + A R + E + ++++
Sbjct: 2070 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129
Query: 2055 DLEITK------ENLAQAVEHRK--KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106
+ ++ E L Q+ E + +AQA+ A+ K+ + Q A R A+ L++
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2186
Query: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166
K++ ++M++ + E+ L Q + +E ++ +L+ +K L+E + ++
Sbjct: 2187 --KQAADAEMEKHKKFAEQTLRQKAQVE-QELTTLRLQLEETDHQKNLLDEELQRLKAEA 2243
Query: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI 2226
+ ++ Q++E L S Q+ +K + ++ + +I K ++F K +++
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV 2303
Query: 2227 RLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
+ SV + ++ EE L + + E + ++Q Q+ T
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEE------DLAQQRALAEKMLKEKMQAVQEA--TRLKAE 2355
Query: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC--KEQKGNLEGIIRQ 2344
ELL Q +E +Q + +L+ + + + QL + + ++ E++ LE
Sbjct: 2356 AELLQQQKEL------AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 2345 QEADIQNSKFSYEQL--ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
+ ++ ++ S Q E D Q R+ + E+++ E L+ +E+ V E+
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEI 2463
Query: 2403 -RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL-- 2459
RQQ D + + L +++ E E L++E K K+ E ++T+++E + Q+ Q
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS----EEMQTVQQEQLLQETQALQ 2519
Query: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
SF+ SL I + +LE+ + + QL +E + ++++E + L + M
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM 2579
Query: 2520 DDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK---- 2575
++ + + + + +E+L Q+ + Q++Q E+ ++N+ L + LEE+
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2635
Query: 2576 LKESEEANEDLRRSFNALQEEKQDL---SKEIESLKVSISQLTRQVTA--LQEEGTLGLY 2630
L SEE + L + L + E E + S L R+V+A LQE G L
Sbjct: 2636 LAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRLQEAGILSAE 2694
Query: 2631 HAQ 2633
Q
Sbjct: 2695 ELQ 2697
Score = 206 bits (524), Expect = 3e-52
Identities = 363/1775 (20%), Positives = 727/1775 (40%), Gaps = 221/1775 (12%)
Query: 817 NELDDVQLQFSEQST-LIRSLQSQLQNKESEVLEGAERV---RHISSKVEELSQALSQKE 872
+EL D++LQ T + L+ L + + E A+R+ + ++VE L + +++
Sbjct: 1014 SELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLS 1071
Query: 873 LEITKMDQLLLEKKRDVETLQQTIE---EKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
E K+ L E TL+ +E K +QV +S EK+ K
Sbjct: 1072 AEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL--------------K 1116
Query: 930 TLKEQLNLLSRAEE---AKKEQVEEDNEVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL 984
T+ + AEE A +EQ++E V + L + + ++ E Q FD L
Sbjct: 1117 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1176
Query: 985 KKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENK 1044
+ E + + E V R E +A L + + + ++ + E+E+
Sbjct: 1177 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1236
Query: 1045 EYSEKCVT-------------SKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Y + + Q + + Q + E+ + Q + +++E E+ Q
Sbjct: 1237 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1296
Query: 1092 ALVKQMNQTLQDKTNQIDLLQAEI-------------SENQAIIQKLITSNTDASD---- 1134
KQ ++D Q+ +A++ S ++++IQ+ + T S+
Sbjct: 1297 RFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTL 1356
Query: 1135 -GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK 1193
+ + ET+ +E + E E++ +E E+ Q++L EA KA
Sbjct: 1357 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKA---- 1411
Query: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ 1253
+ ER +E ++ +++ R +E + ++ +I ++L+QL+ I K +
Sbjct: 1412 --QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469
Query: 1254 QESCSSTPGLEEPL------FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQI 1307
E S +EE + +ATE+ E +E A Q ++
Sbjct: 1470 AER--SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERL 1526
Query: 1308 KAQLKEIEAEKVELELKVSSTT---SELTKKSEEVFQLQEQINKQG---------LEIES 1355
+ Q+++ K + E++++S +E ++ + Q E++ Q E+E
Sbjct: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1586
Query: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
+ V E S + +L+S + A E +L+ L E +++ E+ + Q
Sbjct: 1587 ARQVQVALETAQRSAEAELQSKRASFA--EKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1644
Query: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE-EIGEE 1474
+E E A + + E+ E+ L +L +QA+E ++ Q E + K++ E E
Sbjct: 1645 AEAERAREEAEREL-ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1703
Query: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEK 1534
+A++Q R+ + A + L+++ LA GT ++ + E ++ E
Sbjct: 1704 GKAEEQAVRQRELA----------EQELEKQRQLAEGTAQQRLAA----EQELIRLRAET 1749
Query: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
+ + LL+EE +L E + + Q L + ++ +E L K + +E S
Sbjct: 1750 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809
Query: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST- 1653
+ +EL +E L E + + + R E + + + +
Sbjct: 1810 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1869
Query: 1654 -EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
EA + +TE ++ E+E E E++R+ A+ + + LEE+ + +A++
Sbjct: 1870 GEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE-------- 1919
Query: 1713 CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQAN 1772
E L + ELER K E + ++ + EE+ LK E + +A
Sbjct: 1920 --ERLAQLRKASDSELERQKGLVE-------DTLRQRRQVEEEILALKASFEKAAAGKAE 1970
Query: 1773 LEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSH 1832
LE + + E+ + + R +E + A V K ++
Sbjct: 1971 LEL------ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2024
Query: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVT 1892
+E + + ER+ EE ++ +E ++ E+ + L+Q + K LQ E
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQ-ESARQLQLAQ----EAAQKRLQAEEK 2079
Query: 1893 KMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
QQ ++E L++T ++E+ L+ +L G + +A+
Sbjct: 2080 AHAFAVQQKEQE------LQQTLQQEQSVLD--------QLRGEAEAARRAAEEAEEARV 2125
Query: 1953 LLESEMKNLKKCVSELEEEKQQLVKE-KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
E E ++ V E E KQ ++ + + +++ E L K A++E ++ A+ Q
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAE--Q 2181
Query: 2012 ELLKEKQ------QEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK-----DLEITK 2060
L++KQ ++ K+ + +R + ++ E T L+ +T+ QK +L+ K
Sbjct: 2182 AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLK 2240
Query: 2061 ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQM 2116
+A R + + EL S +V +++ AR+ A+N L+ K Q + +M
Sbjct: 2241 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKM 2300
Query: 2117 KQKDEDLER---------RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
KQ E+ R RL Q E+ L +++ + EK+ + + V E T + + L
Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELL 2359
Query: 2168 KKDKEVQQ-----LQENLDSTVTQLAAFTKSMS-SLQDDRDRVIDEAKKWERKFSDAIQS 2221
++ KE+ Q LQE+ + QLA T+ +L+ +R R ++ + + ER +
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
Query: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
+ R +ED ++ EE+ + R E Q + QT +++Q++ D
Sbjct: 2420 SRAQARAEED--------AQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDH 2470
Query: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-KDQLTDLSNSLEKC-KEQKGNLE 2339
+E +++LE + L E++++ ++QL + +L++ +K +L
Sbjct: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL- 2529
Query: 2340 GIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Q+E I+ K EQL + ++ +++L + EQ+ L++ EEA
Sbjct: 2530 ---LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA---- 2582
Query: 2399 IAELRQQHDKE------IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
R+QH+ E +EL+ L Q ++ +L EEN++ ++ L E + +
Sbjct: 2583 ---RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2639
Query: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
+ A S V + +L N RD + G + E H
Sbjct: 2640 EEVTA---SQVAATKTLPNGRDALDGPAAEAEPEH 2671
Score = 201 bits (511), Expect = 1e-50
Identities = 532/2639 (20%), Positives = 1039/2639 (39%), Gaps = 410/2639 (15%)
Query: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYES----QTAH 790
F A+ LL + ++ T L + L+ + AER R LD E Q
Sbjct: 220 FNAIIHRHKPLLIDMNKVYRQTNL----ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 275
Query: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
+++T + DV+ V NEL QL++ E L+ L +++ + E
Sbjct: 276 KSIITYVSSLYDAMPRVPDVQDGVRANEL---QLRWQEYRELVLLLLQWMRHHTAAFEE- 331
Query: 851 AERVRHISSKVEEL----SQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT-- 904
R S EE+ SQ L KE+E+ + K ++L+ ++ +V
Sbjct: 332 ----RRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPG 387
Query: 905 ----EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLK 960
++ + V + E + L E + L E L + + + EE + L
Sbjct: 388 YHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTKLQMEAGLCEEQLNQADALL 446
Query: 961 QNYDEMSPAGQISKEELQHEFDLLKKENEQRK--RKLQAALINR----KELLQRVSRLEE 1014
Q+ + AG++ + + E DL K ++ R +Q R +++ +RV RL E
Sbjct: 447 QSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 506
Query: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQ 1074
L ++ E N Q ++ L+ E+E
Sbjct: 507 RLVAIRTEY-------------------NLRLKAGVAAPATQVAQVTLQSVQRRPELEDS 547
Query: 1075 HIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDA 1132
+R L++ LA E+ Q V + + ++A++ ++ + Q + + +
Sbjct: 548 TLRY-LQDLLAWVEENQHRVDGAEWGVD-----LPSVEAQLGSHRGLHQSIEEFRAKIER 601
Query: 1133 SDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
+ D L T C G + +L A + E L + A T L
Sbjct: 602 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA-TKELMWLN 660
Query: 1193 KAQEKE-----RHLREELKQQKDDYNRLQEQFD---EQSKENENIGDQLRQLQIQVRESI 1244
+ +E+E + +K+ Y+ L + + ++ KE +N GD+L + R ++
Sbjct: 661 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 720
Query: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH-SEDASALQGGTS 1303
+ F+A Q +L+ LC +H E+A+ Q +
Sbjct: 721 ES---------------------FQAALQTQWSWMLQ--LCCCIEAHLKENAAYFQFFSD 757
Query: 1304 VAQIKAQLKEI-EAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-----QGLEIESLK 1357
V + + QL+++ EA + + S+T + L ++ +EQ+N+ GL +
Sbjct: 758 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 817
Query: 1358 TVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
V + A ++ +L L + + + K DE Q + + LS S
Sbjct: 818 VVQLKPRHPAHPMRGRLPL--LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSS--SG 873
Query: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
EAA+ + + + T+LE Q + QL V++ + A
Sbjct: 874 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----------A 922
Query: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Q ++R +Q + R +L ++L+ E +R ++ Q ++ +
Sbjct: 923 WQSLRRDVQ---LIRSWSLATFRTLKPEE-------QRQALHSLELHYQAFLRDSQDAGG 972
Query: 1538 LGRLALLQEERD---------KLITEMDRSLLEN---QSLSSSCESLKLALEGL-TEDKE 1584
G L ER+ +L+ +++ E Q S + ++L LE T
Sbjct: 973 FGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1032
Query: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE------A 1638
+L ++ + + A+ Q+K Q E E L + +S EAE++ + E
Sbjct: 1033 RLRLPLDKEPARECAQRIAEQQK---AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT 1089
Query: 1639 VRQEKQELYGKL---RSTEANKKETEKQLQ------EAEQEMEEMKEKMRKFAKSKQQKI 1689
+R E + GKL RS A E K + + +E+ E+ K A++ +
Sbjct: 1090 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1149
Query: 1690 LELEEEN---DRLRAEVHPAGDT----------AKECMETLLSSNASMKEELERVKMEYE 1736
ELE +LRA+ T A+E E L + E+ER +
Sbjct: 1150 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1209
Query: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
L +++Q+++++ D E++ L Q+ E A L+ + Q
Sbjct: 1210 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQ 1269
Query: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
E Q+ + E V + +K + + I +Y Q+ K ++ +
Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQR----FAKQYIN--AIKDYELQLVTYKAQLEPV 1323
Query: 1853 EEEKQKNKEFSQTLENEKNTLLSQ---ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
+K K +++ +++ + + T EL L + K I E L R+
Sbjct: 1324 ASPAKKPK-----VQSGSESVIQEYVDLRTHYSELTTLTSQYIKF------ISETLRRME 1372
Query: 1910 KLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV-TDAQIKNELLESEMKNLKKCVSEL 1968
+ + AE+++ + ERL AE+ ++ Q AQ K + E E K L++ + E
Sbjct: 1373 EEERLAEQQRAEERERL----AEVEAALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEE 1427
Query: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE---PGNKSHAKELQELLKEKQQEVKQLQ 2025
+++ + + + I++E + Q ++ E ++ A E L E++ V +LQ
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 2026 KDCIRYQE-----KISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
+ Q ++ AL + E + ++Q++ E + + + +++A+ ELAS
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547
Query: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140
++EAAR L+ +EL+ E + +++Q + + R+++ A E
Sbjct: 1548 V----KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-------T 1596
Query: 2141 MQEKLDA-LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Q +A L+ ++ E +++ +L ++ V QL+E + Q A ++
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA------ 1650
Query: 2200 DRDRVIDEAKKWERKFSDAI----------------QSKEEEIRLKEDNCSVLKDQLRQM 2243
R+ E ++W+ K ++A+ Q++ E+ + + + + + + +
Sbjct: 1651 -REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1709
Query: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKV----CDTLQGENKELLSQLEETRHL 2299
++ EL LE +Q+ E AQ + +Q++ +T QGE + L LEE
Sbjct: 1710 AVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL--LEE---- 1761
Query: 2300 YHSSQNELAKLESELKSLKDQLTDLSNSLEKCK-EQKGNLEGIIRQQEADIQNSKFSYEQ 2358
ELA+L+ E + + +L L K + E + L R +E S+ S ++
Sbjct: 1762 ------ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
LE + REL + E+ +E+A RQ+ + E E L +
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAERVLAEKLAA 1868
Query: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
E + E E A+ + E L+ + ++ Q+ +L+ + Q+ D I
Sbjct: 1869 IGEATRLKTEAEI--ALKEKEAENERLRRLAEDEAFQRRRLEE-----QAAQHKAD-IEE 1920
Query: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRE 2538
QL + S + + L+++ + +++EEI L++ + + A+L+ EL + R
Sbjct: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
Query: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
+ + K+ + + Q Q E E + + EE++++S A E+ R A EE
Sbjct: 1981 NAEDTLRSKEQAELEAAR-QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE-- 2037
Query: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRI-AE 2657
+E LK + + R L+E + ++E +L ++QKR+ AE
Sbjct: 2038 -----VERLKAKVEEARR----LRE-----------RAEQESARQLQLAQEAAQKRLQAE 2077
Query: 2658 LEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVE 2714
+ VQ+ K E++ L++E L L +A R E AEE + R+ +
Sbjct: 2078 EKAHAFAVQQ----KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2133
Query: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774
+++ + + Q Q+ ++ ++ + R A +E + A+L++ K+
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ----KQA 2189
Query: 2775 GLLNRERDALLSETAFSMNSTEENSLS----HLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
E+ +E + E L+ LE+ + Q DE+L L ++ ++ Q
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 2831 --------------VQSFSKAMASLQ------------NERDHLWNELEKFRK-SEEGKQ 2863
++ SK A ++ N + L E EK ++ +EE +
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 2864 RS-AAQPSTSPAEV-------------QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
S AAQ + ++ + LK+ M ++Q + RL E + LQQQ +
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQE 2368
Query: 2910 EITELHPLKAQL-QEYQDKTKAFQIMQEELRQENLSWQHELHQL---------------- 2952
+ L K Q+ Q+ ++T+ FQ E RQ L E +L
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2428
Query: 2953 ---RMEKSSWEIHERRMK-----EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
R K + EI E+ + ++ + + + Q + LR + ++ + K +
Sbjct: 2429 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2488
Query: 3005 YQRQASPETSASPD----GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLE 3060
Q++A S + + L+ ET+ L+ + Q+E I+Q + QL +
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2548
Query: 3061 EKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQE-KNG 3119
++ + QL + Q R+ QQ +E++ Q L A +++ A E + G
Sbjct: 2549 DEVAKAQQLREEQQ--RQQQQ-----------MEQERQRLVA---SMEEARRRQHEAEEG 2592
Query: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
V RK EEL++ +Q + ++ L Q + E +LLEE+ R A ++ V Q+
Sbjct: 2593 VRRKQ--EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ--HRAALAHSEEVTASQV 2647
Score = 184 bits (466), Expect = 2e-45
Identities = 349/1664 (20%), Positives = 696/1664 (41%), Gaps = 229/1664 (13%)
Query: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV- 73
EL G + + ++ + H E D+E E +ER+A QL+ + ++ Q DV
Sbjct: 1179 ELRGAQEVGERLQ-----QRHGERDVEV-----ERWRERVA---QLLERWQAVLAQTDVR 1225
Query: 74 --QLQQKDEALQEERKAAD------NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
+L+Q L+ R++AD ++ + +A + ++ + E Q +L
Sbjct: 1226 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL--- 1282
Query: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL--TQAQAEQP-AQSSTE- 181
E++ +H + E + ++ + +++ E + T +AQL + A++P QS +E
Sbjct: 1283 ----EEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1338
Query: 182 -MEEFVMMKQQLQE----KEEFISTLQAQLSQTQAEQ--AAQQVVREKDARFETQVRLHE 234
++E+V ++ E ++I + L + + E+ A QQ E++ E + L +
Sbjct: 1339 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1398
Query: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEH----EESLVGRAQVVDLLQQELTAAEQRNQ 290
L A + + +++ + LQ++++E EE+ V Q +Q+EL Q ++
Sbjct: 1399 QRQLA-EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 291 --ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
I ++ Q AE + LR E +I + +++LE ER+ + E+ L +
Sbjct: 1458 AEIQAKARQAEAAERSRLRI-------EEEIRVVRLQLEATERQRG--GAEGELQALRAR 1508
Query: 349 FEQA------GQAQAELESRYSALEQKHKAEME-EKTSHILSLQKTGQELQSACDALKDQ 401
E+A Q +AE R E + K + E E S + + + +E Q A AL+
Sbjct: 1509 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE-- 1566
Query: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
E +Q+ + ++L ++++++ L ETA +++
Sbjct: 1567 ---------ELRLQAEEAERRLRQAEVERARQVQVAL--------ETAQRSA-------- 1601
Query: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
+A + AS ++ +LE +L + + +L+ E E+ + Q EA+ EA+
Sbjct: 1602 -EAELQSKRASFAEKTAQLER---SLQEEHVAVAQLREEAERRAQQ--QAEAERAREEAE 1655
Query: 522 REVS--EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQ 579
RE+ ++ + R + E + Q L ++K KE EA+ E
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE---------EAERE------- 1699
Query: 580 LQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQ 639
+R +A+ + + Q+E+ + E E K + E T Q L +E E EQ
Sbjct: 1700 --ARRRGKAEEQAVRQRELAEQELE-----KQRQLAEGTAQQ-RLAAEQELIRLRAETEQ 1751
Query: 640 ASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELN 699
+ Q E L +Q+ + L+ V + E+E L + E
Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-------RAEMEVLLASKARAEEE 1804
Query: 700 FHKAQEIYEKNLD-------EKAKEISNLNQLIEEFKKNAD-NNSSAFTALSEERDQLLS 751
E ++ L+ E A+E + L L EE K+ A +E L
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1864
Query: 752 QVKELSMVTELRAQVK-QLEMNLAEAERQRRLDYESQTAHDNLLTEQI--HSLSIE---- 804
++ + T L+ + + L+ AE ER RRL E + L EQ H IE
Sbjct: 1865 KLAAIGEATRLKTEAEIALKEKEAENERLRRL-AEDEAFQRRRLEEQAAQHKADIEERLA 1923
Query: 805 --AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
K+ D ++E + ++D Q + I +L++ + + E + I S E
Sbjct: 1924 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1983
Query: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
+ ++ Q ELE + QL E++R ++ +++ L E+
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK-----------------SLAAEEE 2026
Query: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
+ L+E L ++ EEA++ + E E S + + + ++ EE H F
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARR--LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084
Query: 983 LLKKENE--QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED 1040
+ +KE E Q ++ Q+ L + + R EE + ++++E S + E E
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERL 2144
Query: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
K++ E + E K+ E Q + L +K AA+ + + K QT
Sbjct: 2145 KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT 2204
Query: 1101 LQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKP 1160
L+ K A++ + ++ + + +D L +E + T ++ +
Sbjct: 2205 LRQK--------AQVEQELTTLRLQL----EETDHQKNLLDEELQRLKAEATEAARQ-RS 2251
Query: 1161 ELEEKILALEKEKEQLQK-KLQEALTSRKAILKKAQEKERHLREE---LKQQKDDYNRLQ 1216
++EE++ ++ + E+L K K + +R IL+ +R L+EE +KQ ++ RL
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311
Query: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHT 1276
E ++ + + L Q + + + K+ + + + L + + ++
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371
Query: 1277 QPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKS 1336
+ L+ + +E+ Q T A+ + QL E+ AE L+L+V+ + +
Sbjct: 2372 R--LQEDKEQMAQQLAEETQGFQ-RTLEAERQRQL-EMSAEAERLKLRVAEMSRAQARAE 2427
Query: 1337 EEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL-EHLRELQPKLD 1395
E+ + ++Q + G ++ + + E ++L+ + + S L E + EL+ + +
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
Query: 1396 ELQ---KLISKKEEDVSYLSGQ-------------LSEKEAAL--------TKIQTEIIE 1431
+LQ KL+ K E++ + + LSEK++ L K + E +
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
Query: 1432 QEDLIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Q+++ KA L + + Q ++ ++ ++L + E +++ E E R KQ+ ++L+
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2607
Query: 1490 ISRKEAL-KENKSLQEELSLARGTIERLTKSLADVE----SQVSAQN---KEKDTVLGRL 1541
++E L +EN+ L+E+L L E+ +LA E SQV+A +D + G
Sbjct: 2608 RQQEELLAEENQRLREQLQLLE---EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Query: 1542 ALLQEER--DKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
A + E D L ++ L+ + S+ E +LA T D+
Sbjct: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2708
Score = 159 bits (401), Expect = 6e-38
Identities = 385/1943 (19%), Positives = 761/1943 (39%), Gaps = 319/1943 (16%)
Query: 1370 LQQKLESSQLQIAGLEHLRELQP---KLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
L + E +L +A LE ++L+ +L+ LQ++++K + + QL++ +A L Q
Sbjct: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALL---Q 447
Query: 1427 TEI-IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
+++ + + ++E + D I+ L ++ +K G + +Q +R
Sbjct: 448 SDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD-----GRHPQGEQMYRRVY 502
Query: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQ 1545
+ L R A++ +L+ + +A + +L V+ + ++ + LA ++
Sbjct: 503 R--LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 560
Query: 1546 EERDKL--------ITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK 1597
E + ++ + ++ L ++ L S E + +E D+ +L
Sbjct: 561 ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP--------- 611
Query: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
A +++ L +Y LL S + E + V A +E L E +
Sbjct: 612 -ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL------NEKEE 664
Query: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKS---KQQKILELEEENDRLRAEVHPAGDTAKE-- 1712
+E + M KE + K++KI EL+ DRL E HPA T +
Sbjct: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
Query: 1713 ---------------CMETLLSSNAS-------MKEELERVKMEYETLSKKFQ----SLM 1746
C+E L NA+ ++E +++ E L +K+ + +
Sbjct: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
Query: 1747 SEKDSLSEEVQDLKHQIE------GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
+ + L ++ QD K Q+ ++K+A K + + + +Q
Sbjct: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
Query: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI----DQLKERIAGLEEEK 1856
+++ C + V A+ ++ V S + + + + +E + LE +
Sbjct: 845 VEVTVHKGDEC-QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 903
Query: 1857 QKNKEFSQTLENEKNTLLS-QISTKDGELKMLQEEVTKMNLLNQQIQE-----ELSRVTK 1910
Q L + +LL+ Q +D +L T L ++ ++ EL
Sbjct: 904 QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 963
Query: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
L+++ + E+RLM + GS ++ Q + + + ES + +C+SEL++
Sbjct: 964 LRDSQDAGGFGPEDRLMAEREY--GSCSHHYQQLLQSLEQGAQEESRCQ---RCISELKD 1018
Query: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ---EVKQLQKD 2027
+ QL +T+ +R P +K A+E + + E+Q+ EV+ L K
Sbjct: 1019 IRLQLEACETRTVHRLRL------------PLDKEPARECAQRIAEQQKAQAEVEGLGKG 1066
Query: 2028 CIRYQ---EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
R EK+ AL A +++E LE+T L Q +L + +++
Sbjct: 1067 VARLSAEAEKVLALPEPSPAAPTLRSE----LELTLGKLEQVRSLSAIYLEKLKTISLVI 1122
Query: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
TQ A VL + + KE Q+ ++ +++ L++ QAE + Q
Sbjct: 1123 RGTQG-AEEVLRAHEEQLKEAQAVPATLP-ELEATKASLKKLRAQAEAQ--------QPT 1172
Query: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
DALR E +E +Q ++D EV++ +E V QL +++ + D R R
Sbjct: 1173 FDALRDELRGAQEVGERLQQRHGERDVEVERWRER----VAQLLERWQAVLAQTDVRQRE 1228
Query: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
+++ + ++R ++ L L+ E+++ +
Sbjct: 1229 LEQLGR--------------QLRYYRESADPLGAWLQDARRRQEQIQA--------MPLA 1266
Query: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
+S+A E QL+Q+ L E + ++EE + N + E +L + K QL +
Sbjct: 1267 DSQAVRE-QLRQE--QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1323
Query: 2325 SNSLEKCKEQKGNLEGI-----IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
++ +K K Q G+ I +R +++ Y + ++ E RL E+
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
Query: 2380 KEQKIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
+E++ ++ + K+ + A A+ + Q ++E KEL+ Q +E +V EE AVD
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREE--AAVD 1437
Query: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Q K +IQ+ + QQL + + I K +
Sbjct: 1438 AQQQ---------KRSIQE-----------------------ELQQLRQSSEAEIQAKAR 1465
Query: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
+ A +++EEIR +R ++ + + EL R + K Q++
Sbjct: 1466 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1525
Query: 2557 VQLQQNKELENKY---AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
++ Q E + K +L ++K EA + +R+ AL+E +
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR---------------- 1569
Query: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
LQ E A+ ++++ EV R + + + E EL + A+K
Sbjct: 1570 -------LQAE------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1616
Query: 2674 GEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL-LMVTKENKGLTAQ 2732
++E L++E H +R E E ++ AE R E E++L K N+ L +
Sbjct: 1617 AQLERSLQEE----HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 2733 IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
+Q+ + + A E ++ K + + + + +EQ + RE L+E
Sbjct: 1673 LQA-----EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE----LAEQEL-- 1721
Query: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-------R 2845
E E QQ L+ +++L+ L ++ E Q Q + +A LQ E R
Sbjct: 1722 ----EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Query: 2846 DHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
L EL K R E S A+ +++ S+ + + RL E +
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAE---------EESRSTSEKSKQRLEAEAGRFR---- 1824
Query: 2906 QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH-ELHQLRMEKSSWEIHER 2964
EL A+L+ ++ K Q +L +E+ + Q E ++ EK +
Sbjct: 1825 -------ELAEEAARLRALAEEAKR----QRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 2965 RMKEQYLMAISDKDQQLSHLQNLI-------RELRSSSSQTQPLKVQYQRQASPETSASP 3017
R+K + +A+ +K+ + L+ L R L ++Q + + Q + +
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 3018 DGSQNLVYETELLRTQLND---SLKEIHQK--------ELRIQQLNSNFSQLLEEKNTLS 3066
+ + LV +T R Q+ + +LK +K EL + ++ SN L K
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 3067 IQLCDTSQSLRENQQHYGD----LLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR 3122
++ Q E ++ + + A E+ ++ +A ++ +E +
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 3123 KSDPEELREPQQSFSEAQQQL--------CNTRQEVNELRKLLEEE-------RDQRVAA 3167
+++ E R+ Q + AQ++L +Q+ EL++ L++E R + AA
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113
Query: 3168 ENALSVAEEQIRRLEHSEWDSSR 3190
A AEE + E S R
Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRR 2136
Score = 130 bits (326), Expect = 3e-29
Identities = 231/1078 (21%), Positives = 429/1078 (39%), Gaps = 174/1078 (16%)
Query: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQE-ERKAADNKIKK 95
E ++E E ++ AEQ ++ L+ Q + Q Q +E L +R+AA K+
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Query: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL-SKHDKSSTEEEMEIEKIKHKLQ 154
+L A+ + +++A+ +L ++ ++EE+ S +KS E E + + +
Sbjct: 1778 QELEAE---------LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Query: 155 EKEELISTLQAQLTQAQA--EQPAQSSTEMEEFVMMK-QQLQEKEEFISTLQAQLSQTQA 211
E L + + Q Q E A+ E E + K + E + + L + +A
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
Query: 212 EQAAQQVVREKDA----RFETQVRLH----EDELLQLVTQADVETEMQQKLRV----LQR 259
E + + E +A R E Q H E+ L QL +D E E Q+ L +R
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1948
Query: 260 KLEEH--------EESLVGRAQVV-----------DLL----QQELTAAEQRNQILSQQL 296
++EE E++ G+A++ D L Q EL AA QR ++
Sbjct: 1949 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 2008
Query: 297 QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQ 356
++ EAE ++ EE K LE ER + EE L E+ EQ Q
Sbjct: 2009 RRREAEERVQKSLAA---EEEAARQRKAALEEVERLKA---KVEEARRLRERAEQESARQ 2062
Query: 357 AEL-----ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNS---KLLQD 408
+L + R A E+ H +++K LQ+T Q+ QS D L+ + + ++
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE---LQQTLQQEQSVLDQLRGEAEAARRAAEE 2119
Query: 409 KNEQAVQS----AQTIQQLED--QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462
E VQ+ AQ+ +Q+E+ +L+Q ++E +Q Q + A++ + E
Sbjct: 2120 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ-----ARAQAQAAAEKLRKEAEQEAA 2174
Query: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADR 522
+ E A QK+ + E EK ++ + E E + ++ L E ++ D
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234
Query: 523 EVSEISI--VDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
E+ + + A +RS EE L ++ EE++ LK ++
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEE--------------------LFSVRVQMEELSKLKARI 2274
Query: 581 QGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQA 640
+ + + + + Q E E KMK E+ + + E + L + +E
Sbjct: 2275 EAENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAAR-LSVAAQEAARLRQLAEEDL 2328
Query: 641 STEH---QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
+ + + E++ LK+ + + + + Q++ E++ Q+ E
Sbjct: 2329 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2388
Query: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK---NADNNSSAFTALSEERDQLLSQVK 754
F + E + E + E L + E + A+ ++ F +EE + L +
Sbjct: 2389 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR-- 2446
Query: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIE 813
TEL Q K + E +RQ Q+ HD L E I L E + + +
Sbjct: 2447 -----TELATQEKVTLVQTLEIQRQ-------QSDHDAERLREAIAELEREKEKLQQEAK 2494
Query: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKEL 873
+LQ L ++Q +Q L++ Q+ Q+ SE +R R I E
Sbjct: 2495 LLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI--------------EQ 2538
Query: 874 EITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE 933
E K++QL ++ + L++ + + QQ+ + + M + + ++ +E
Sbjct: 2539 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2598
Query: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPA------------------------ 969
+L L + ++E + E+N+ Q +E A
Sbjct: 2599 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2658
Query: 970 ---GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKD 1021
G ++ E +H FD L++ + ++LQ A I E LQR+++ +ELA +D
Sbjct: 2659 ALDGPAAEAEPEHSFDGLRR--KVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2714
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.309
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 106,359,037
Number of Sequences: 37866
Number of extensions: 5049219
Number of successful extensions: 112958
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 858
Number of HSP's successfully gapped in prelim test: 1822
Number of HSP's that attempted gapping in prelim test: 23153
Number of HSP's gapped (non-prelim): 33119
length of query: 3259
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3138
effective length of database: 13,665,732
effective search space: 42883067016
effective search space used: 42883067016
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.