Search of human proteins with 148277064

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
         (1505 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]            2938   0.0  
gi|116517292 cut-like 2 [Homo sapiens]                               1050   0.0  
gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]              746   0.0  
gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]              738   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        87   2e-16
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        87   2e-16
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         87   2e-16
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         87   2e-16
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         87   2e-16
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         87   2e-16
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         87   2e-16
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         87   2e-16
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    82   3e-15
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       81   9e-15
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       81   9e-15
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        81   9e-15
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        81   9e-15
gi|122937424 one cut homeobox 3 [Homo sapiens]                         79   3e-14
gi|24307887 one cut homeobox 1 [Homo sapiens]                          78   6e-14
gi|21735548 centrosomal protein 2 [Homo sapiens]                       77   1e-13
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     77   1e-13
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    77   1e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    77   1e-13
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]                75   6e-13
gi|4506751 restin isoform a [Homo sapiens]                             74   8e-13
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]         74   1e-12
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    74   1e-12
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]         73   2e-12
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  72   3e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             71   7e-12

>gi|148277064 cut-like homeobox 1 isoform a [Homo sapiens]
          Length = 1505

 Score = 2938 bits (7617), Expect = 0.0
 Identities = 1505/1505 (100%), Positives = 1505/1505 (100%)

Query: 1    MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF 60
            MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF
Sbjct: 1    MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF 60

Query: 61   QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120
            QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE
Sbjct: 61   QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120

Query: 121  TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
            TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ
Sbjct: 121  TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN
Sbjct: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
            QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA
Sbjct: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300

Query: 301  QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI 360
            QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI
Sbjct: 301  QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNI 360

Query: 361  LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES 420
            LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES
Sbjct: 361  LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPES 420

Query: 421  RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL 480
            RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL
Sbjct: 421  RRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFAL 480

Query: 481  NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE 540
            NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE
Sbjct: 481  NSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSE 540

Query: 541  SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT 600
            SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT
Sbjct: 541  SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT 600

Query: 601  VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI 660
            VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI
Sbjct: 601  VRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRI 660

Query: 661  RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ 720
            RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ
Sbjct: 661  RASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQ 720

Query: 721  QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN 780
            QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN
Sbjct: 721  QAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPN 780

Query: 781  PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE 840
            PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE
Sbjct: 781  PPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEE 840

Query: 841  AKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA 900
            AKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA
Sbjct: 841  AKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGA 900

Query: 901  SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG 960
            SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG
Sbjct: 901  SRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNG 960

Query: 961  ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ 1020
            ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ
Sbjct: 961  ICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQ 1020

Query: 1021 QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP 1080
            QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP
Sbjct: 1021 QQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPP 1080

Query: 1081 IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT 1140
            IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT
Sbjct: 1081 IEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLT 1140

Query: 1141 DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD 1200
            DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD
Sbjct: 1141 DNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMD 1200

Query: 1201 MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK 1260
            MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK
Sbjct: 1201 MKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALK 1260

Query: 1261 RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD 1320
            RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD
Sbjct: 1261 RAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASD 1320

Query: 1321 SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT 1380
            SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT
Sbjct: 1321 SPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGT 1380

Query: 1381 PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP 1440
            PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP
Sbjct: 1381 PGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPP 1440

Query: 1441 PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP 1500
            PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP
Sbjct: 1441 PSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEP 1500

Query: 1501 IEWEF 1505
            IEWEF
Sbjct: 1501 IEWEF 1505


>gi|116517292 cut-like 2 [Homo sapiens]
          Length = 1486

 Score = 1050 bits (2714), Expect = 0.0
 Identities = 691/1580 (43%), Positives = 916/1580 (57%), Gaps = 194/1580 (12%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            RL++EL++ A+ L+ RQ+ESE S K LIE  REFKKN PE++R+ VAP+LKSFQ E+ AL
Sbjct: 19   RLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVAL 78

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE--TLEEY 125
            SKRS+EAEAAFL+VYK+LI+ PDPVP  +  + L  ++Q     +   Q  R+  T  + 
Sbjct: 79   SKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQP-PSFDPSGQPRRDLHTSWKR 137

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
            N E    K Q          + E  +      +  AL  E  LQ + AEK++ LQE Q++
Sbjct: 138  NPELLSPKEQREGTSPAGPTLTEGSRLPGIPGK--ALLTETLLQRNEAEKQKGLQEVQIT 195

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 245
              ++L EAE K++ L +AL+ T+ EL +L+ KYDEE  +KADE+ +IMT+LE+ANQRAE 
Sbjct: 196  LAARLGEAEEKIKVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEA 255

Query: 246  AQREAETLREQLSSANHSLQLASQIQKAPDVEQA-IEVLTRSSLEVELAAKEREIAQLVE 304
            AQRE E+LREQL+S N S++LA    + P  ++    + +   LE  LA+K+REI +L++
Sbjct: 256  AQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLK 315

Query: 305  DVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSM 364
            DVQ LQ+SL +L E SA+QI+ LE+QL+AK+  +++LEEKL+ Q+DYEE+K EL+ILK+M
Sbjct: 316  DVQHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAM 375

Query: 365  EFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPG 424
            + A S  +  Q  AKP + LL+ K     ++   L   +   S        D  +     
Sbjct: 376  KLASSTCSLPQGMAKPEDSLLIAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGT 435

Query: 425  SLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALN--- 481
                P P QLP  PG +          SP+          L  PSL    T  F+L+   
Sbjct: 436  EQSYPSPQQLPPPPGPE-------DPLSPSP------GQPLLGPSLGPDGTRTFSLSPFP 482

Query: 482  SLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSES 541
            SL   + +    +    EAG   ++F    Y     ++ +     P+  G  P P+    
Sbjct: 483  SLASGERLMMPPAAFKGEAGGL-LVFPPAFYGAKPPTAPATPAPGPEPLG-GPEPADGGG 540

Query: 542  AGSVSEG---EEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNK 598
             G+   G   E++DTAEIA QVKEQL+KHNIGQR+FGHYVLGLSQGSVSEILARPKPW K
Sbjct: 541  GGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRK 600

Query: 599  LTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITT 658
            LTV+GKEPF KMKQFLSDEQN+LALR+IQ RQR                      G+IT 
Sbjct: 601  LTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQR----------------------GSITP 638

Query: 659  RIRASETGSDEAIKSILEQAKRELQVQKTAEP----AQPSSASGS---GNSDDAIRSILQ 711
            RIR  ETGSD+AIKSILEQAK+E++ QK  EP    A  S A+G+     S+DAI+SIL+
Sbjct: 639  RIRTPETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILE 698

Query: 712  QARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAP 771
            QARREM+AQQ AL                     L     P   S PP       P   P
Sbjct: 699  QARREMQAQQQAL---------------------LEMEVAPRGRSVPP------SPPERP 731

Query: 772  EAGASALPNPPALKKEAQDAPG-----LDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWS 826
                ++    PAL K+ + + G     L     A   Q ++R+VK+E+G +G +  HW S
Sbjct: 732  SLATASQNGAPALVKQEEGSGGPAQAPLPVLSPAAFVQSIIRKVKSEIGDAGYFDHHWAS 791

Query: 827  AVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAE 886
                  R  AS   + +  +  G    SG   G + PR + + +     +        AE
Sbjct: 792  DRGLLSRPYASVSPSLSSSSSSGY---SGQPNGRAWPRGDEAPVPPEDEAA-----AGAE 843

Query: 887  SPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTI 946
                ++ EL   GA+       + LP  P   + +  KP+VPPLTPEQYE+YMY+EVDT+
Sbjct: 844  DEPPRTGELKAEGATAEA---GARLPYYPAY-VPRTLKPTVPPLTPEQYELYMYREVDTL 899

Query: 947  ELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWL 1006
            ELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWL
Sbjct: 900  ELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWL 959

Query: 1007 NGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSES 1066
            + +LGQ V    GQQ G                  +S + P++S S  P+P  P  SS+ 
Sbjct: 960  SDQLGQAV----GQQPG---------------ASQASPTEPRSSPSPPPSPTEPEKSSQE 1000

Query: 1067 VKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPEL 1126
              SL+         +E+SK+++ PE      S S  +  +     +   IQE+VAMSPEL
Sbjct: 1001 PLSLS---------LESSKENQQPEGR----SSSSLSGKMYSGSQAPGGIQEIVAMSPEL 1047

Query: 1127 DTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQ 1186
            DTY ITKRVKEVLTDNNLGQRLFGE+ILGLTQGSVSDLL+RPKPWHKLSLKGREPFVRMQ
Sbjct: 1048 DTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQ 1107

Query: 1187 LWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQH---- 1242
            LWLNDP+NVEKL DMK++EKKAY+KRR+  +S     E P+  +E       QPQ     
Sbjct: 1108 LWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSE-CPSPCLQPQDLSLL 1166

Query: 1243 QLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRE 1302
            Q+KKPRVVLAPEEKEAL++AYQ +PYPS +TIE L+ QLNLKT+TVINWFHNYRSR+RRE
Sbjct: 1167 QIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRRE 1226

Query: 1303 LFIEEIQ-------AGSQG---QAGASDSPSARSGRAAPSSEGDSCDGVEATEGP---GS 1349
            + +E  Q       +G  G      +   P+ +S  +    +  +   +E  EGP    +
Sbjct: 1227 MLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENST 1286

Query: 1350 ADTEEPKSQGEAEREEVPRPAEQ---TEPPPSGT----PGPDDARDDD---HEGGPVEGP 1399
              T + K+Q   ++E++   AE+   ++P  SG      GP      D   ++G P   P
Sbjct: 1287 PLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAP 1346

Query: 1400 GPL-------------------------PSPAS--ATATAAPAAPEDAATSAAAAPGEGP 1432
            GPL                         P P S  + + ++  + E +  S +AA   G 
Sbjct: 1347 GPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASESSRCSLEVSLNSPSAASSPGL 1406

Query: 1433 AAPSSAPPPSNSSSSSAP--RRPSSLQSLFGLPEAAGA--RDSRDNP---LRKKKAANLN 1485
                S  P S++  S +P    P+ + S     + AGA    ++ NP    R +K ANLN
Sbjct: 1407 MMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLN 1466

Query: 1486 SIIHRLEKAASREEPIEWEF 1505
            +II+R+E+AA+REE +EWEF
Sbjct: 1467 NIIYRVERAANREEALEWEF 1486


>gi|31652236 cut-like homeobox 1 isoform b [Homo sapiens]
          Length = 678

 Score =  746 bits (1927), Expect = 0.0
 Identities = 399/401 (99%), Positives = 401/401 (100%)

Query: 8   RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
           +L+RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL
Sbjct: 19  QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 78

Query: 68  SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127
           SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK
Sbjct: 79  SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138

Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
           EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT
Sbjct: 139 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 198

Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
           SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ
Sbjct: 199 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 258

Query: 248 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307
           REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ
Sbjct: 259 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 318

Query: 308 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 367
           RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA
Sbjct: 319 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 378

Query: 368 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 408
           PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG
Sbjct: 379 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 419



 Score = 35.0 bits (79), Expect = 0.55
 Identities = 35/168 (20%), Positives = 76/168 (45%), Gaps = 18/168 (10%)

Query: 557 ARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSD 616
           A  ++EQL   N   ++              E+L R     +L  + +E    + Q + D
Sbjct: 261 AETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE----IAQLVED 316

Query: 617 EQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILE 676
            Q + A  +   + REN    +++L Q++   +N +   +  +++          ++  E
Sbjct: 317 VQRLQASLT---KLRENSASQISQLEQQL-SAKNSTLKQLEEKLKG---------QADYE 363

Query: 677 QAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAAL 724
           + K+EL + K+ E A PS  +G+ ++   +  +L +  R ++++ AAL
Sbjct: 364 EVKKELNILKSMEFA-PSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 410


>gi|31652238 cut-like homeobox 1 isoform c [Homo sapiens]
          Length = 676

 Score =  738 bits (1904), Expect = 0.0
 Identities = 397/401 (99%), Positives = 399/401 (99%), Gaps = 2/401 (0%)

Query: 8   RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
           +L+RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL
Sbjct: 19  QLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 78

Query: 68  SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127
           SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK
Sbjct: 79  SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 138

Query: 128 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
           EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT
Sbjct: 139 EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 198

Query: 188 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
           SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ
Sbjct: 199 SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 258

Query: 248 REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307
           REAETLREQLSSANHSLQLASQIQKAPDV  AIEVLTRSSLEVELAAKEREIAQLVEDVQ
Sbjct: 259 REAETLREQLSSANHSLQLASQIQKAPDV--AIEVLTRSSLEVELAAKEREIAQLVEDVQ 316

Query: 308 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 367
           RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA
Sbjct: 317 RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFA 376

Query: 368 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 408
           PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG
Sbjct: 377 PSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSG 417



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 30/137 (21%), Positives = 67/137 (48%), Gaps = 18/137 (13%)

Query: 588 EILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPK 647
           E+L R     +L  + +E    + Q + D Q + A  +   + REN    +++L Q++  
Sbjct: 290 EVLTRSSLEVELAAKERE----IAQLVEDVQRLQASLT---KLRENSASQISQLEQQL-S 341

Query: 648 RRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIR 707
            +N +   +  +++          ++  E+ K+EL + K+ E A PS  +G+ ++   + 
Sbjct: 342 AKNSTLKQLEEKLKG---------QADYEEVKKELNILKSMEFA-PSEGAGTQDAAKPLE 391

Query: 708 SILQQARREMEAQQAAL 724
            +L +  R ++++ AAL
Sbjct: 392 VLLLEKNRSLQSENAAL 408


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1478

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1479 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1530 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1586

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1641

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1931

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 1992 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2040

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2091

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1201

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1202 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1253

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1254 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1292

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1410

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1523

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1524 EAEAAREKQR 1533



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2239 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2347

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2348 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2396

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2397 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2430

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2431 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2475

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535

Query: 419  ESRR 422
              ++
Sbjct: 2536 RQQQ 2539



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 2014 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2062 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2117

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2118 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2177 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAER 2384



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2682 LARREDVRHYLQGRSSIAGLLLKATNEKL 2710



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1175

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1176 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIE 1259


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1482

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1483 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1534 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1590

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1645

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1646 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1705

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1763

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1823

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1883

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1935

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 1996 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2044

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2095

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1151 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1205

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1206 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1257

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1258 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1296

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1414

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1415 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1527

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1528 EAEAAREKQR 1537



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2243 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2351

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2352 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2400

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2401 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2434

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2435 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2479

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539

Query: 419  ESRR 422
              ++
Sbjct: 2540 RQQQ 2543



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 2018 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2066 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2121

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2122 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2181 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2299

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2300 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAER 2388



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2448 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2626

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2627 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2685

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2686 LARREDVRHYLQGRSSIAGLLLKATNEKL 2714



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1029 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1078

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1079 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1133

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1179

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1180 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1239 AMPLADSQAVREQLRQEQALLEEIE 1263


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1478

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1479 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1530 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1586

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1641

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1701

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1931

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 1992 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2040

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2091

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1201

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1202 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1253

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1254 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1292

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1410

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1523

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1524 EAEAAREKQR 1533



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2239 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2347

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2348 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2396

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2397 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2430

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2431 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2475

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535

Query: 419  ESRR 422
              ++
Sbjct: 2536 RQQQ 2539



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 2014 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2062 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2117

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2118 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2177 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2295

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAER 2384



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2444 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2622

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2681

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2682 LARREDVRHYLQGRSSIAGLLLKATNEKL 2710



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1025 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1074

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1075 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1129

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1175

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1176 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1235 AMPLADSQAVREQLRQEQALLEEIE 1259


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1446

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1447 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1498 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1554

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1609

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1610 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1669

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1727

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1787

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1847

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1899

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 1960 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2008

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2059

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2118

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1115 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1169

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1170 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1221

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1222 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1260

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1378

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1379 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1491

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1492 EAEAAREKQR 1501



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2207 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2315

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2316 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2364

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2365 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2398

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2399 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2443

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503

Query: 419  ESRR 422
              ++
Sbjct: 2504 RQQQ 2507



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 1982 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2030 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2085

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2086 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2145 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2263

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2264 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAER 2352



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2412 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2590

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2591 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2649

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2650 LARREDVRHYLQGRSSIAGLLLKATNEKL 2678



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 993  EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1042

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1043 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1097

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1143

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1144 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1203 AMPLADSQAVREQLRQEQALLEEIE 1227


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1615

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1616 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1667 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1723

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1778

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1779 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1838

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1896

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1956

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 2016

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 2017 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 2068

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 2129 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2177

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2228

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1284 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1338

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1339 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1390

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1391 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1429

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1547

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1548 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1660

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1661 EAEAAREKQR 1670



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2376 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2484

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2485 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2533

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2534 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2567

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2568 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2612

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672

Query: 419  ESRR 422
              ++
Sbjct: 2673 RQQQ 2676



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 2151 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2199 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2254

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2255 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2314 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2432

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2433 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAER 2521



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2581 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2759

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2760 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2818

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2819 LARREDVRHYLQGRSSIAGLLLKATNEKL 2847



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1211

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1212 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1266

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1312

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1313 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1372 AMPLADSQAVREQLRQEQALLEEIE 1396


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1456

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1457 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1508 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1564

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1619

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1620 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1679

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1737

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1797

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1857

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 1858 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1909

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 1970 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2018

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2069

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2128

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1125 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1179

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1180 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1231

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1232 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1270

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1388

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1389 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1501

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1502 EAEAAREKQR 1511



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2217 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2325

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2326 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2374

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2375 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2408

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2409 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2453

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2513

Query: 419  ESRR 422
              ++
Sbjct: 2514 RQQQ 2517



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 1992 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2040 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2095

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2096 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2155 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2273

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2274 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAER 2362



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2422 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2481 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2600

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2601 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2659

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2660 LARREDVRHYLQGRSSIAGLLLKATNEKL 2688



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1003 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1052

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1053 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1107

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1153

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1154 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1213 AMPLADSQAVREQLRQEQALLEEIE 1237


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1464

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1465 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1516 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1572

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1627

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1628 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1687

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1745

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1805

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1865

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 1866 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1917

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 1978 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2026

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2077

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2136

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1133 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1187

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1188 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1239

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1240 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1278

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1396

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1397 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1509

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1510 EAEAAREKQR 1519



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2165 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2225 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2333

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2334 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2382

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2383 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2416

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2417 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2461

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2462 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2521

Query: 419  ESRR 422
              ++
Sbjct: 2522 RQQQ 2525



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 2000 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2048 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2103

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2104 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2163 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2281

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2282 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAER 2370



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2430 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2489 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2608

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2609 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2667

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2668 LARREDVRHYLQGRSSIAGLLLKATNEKL 2696



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1011 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1060

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1061 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1115

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1161

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1162 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1221 AMPLADSQAVREQLRQEQALLEEIE 1245


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 183/828 (22%), Positives = 315/828 (38%), Gaps = 140/828 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            +L++  +A     A + + +E+SR R+ E+ R  +       R++        +GE+ AL
Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA-----EGELQAL 1505

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETE------------- 114
              R++EAEA      +          A  L +Q+Q + QR    E E             
Sbjct: 1506 RARAEEAEAQKRQAQEE---------AERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556

Query: 115  -NQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
              Q+  + LEE   +  E + +    +A  E+ R+ +  L+    +   E + K +  FA
Sbjct: 1557 EKQRALQALEELRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQSK-RASFA 1613

Query: 174  EK----ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI 229
            EK    ER LQE  ++     EEAE + Q  Q   E+ R E      +  E    KA+E 
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQ-QAEAERAREEA----ERELERWQLKANEA 1668

Query: 230  EMIMTDLERANQRAEVAQREAETLRE-------------------------------QLS 258
              +    E   Q+  +AQ EAE  +E                               QL+
Sbjct: 1669 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA 1728

Query: 259  SANHSLQLASQ---IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                  +LA++   I+   + EQ  +   R  LE ELA  +RE A   +  Q L+A L K
Sbjct: 1729 EGTAQQRLAAEQELIRLRAETEQGEQ--QRQLLEEELARLQREAAAATQKRQELEAELAK 1786

Query: 316  LR--------------ENSASQISQLEQQLSAKNSTLKQL-EEKLKGQADYEEVKKELNI 360
            +R              E S S   + +Q+L A+    ++L EE  + +A  EE K++  +
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1846

Query: 361  LK---SMEFAPSEGAGTQDAAKPLEVLLLEKNRSL-----QSENAALRISNSDLSGSARR 412
             +   + + A +E    +  A   E   L+    +     ++EN  LR    D +   RR
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1906

Query: 413  KGKDQPESR-----RPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
              +   + +     R   L     S+L R  G          Q     L+          
Sbjct: 1907 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--------LK 1958

Query: 468  PSLPLASTGKFALNSLLQR---QLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQ 524
             S   A+ GK  L   L R       +  SK   E  +                ++  +Q
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018

Query: 525  QSPDVNGMAPSPSQSESAGSVSEGEEMDT-AEIARQVKEQLIKHNIGQRIFGHYVLGLSQ 583
            +S      A   +  +   ++ E E +    E AR+++E+  + +  Q       L L+Q
Sbjct: 2019 KSL----AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ-------LQLAQ 2067

Query: 584  GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQ 643
             +  + L   +  +   V+ KE   +++Q L  EQ++L        Q     ++  R  +
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKE--QELQQTLQQEQSVL-------DQLRGEAEAARRAAE 2118

Query: 644  EVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSD 703
            E  + R  +E       R  E  ++   +S  EQA+   Q Q  AE  +  +   +    
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEE-AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2177

Query: 704  DAIRSILQQ---ARREMEAQQAALDPALKQAPLSQSDITILTPKLLST 748
             A ++ L+Q   A  EME  +   +  L+Q    + ++T L  +L  T
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 94/430 (21%), Positives = 177/430 (41%), Gaps = 64/430 (14%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKE 73
            DA    L   Q+  E+ ++R  E+  E ++      R++VA LL+ +Q  +     R +E
Sbjct: 1174 DALRDELRGAQEVGERLQQRHGERDVEVER-----WRERVAQLLERWQAVLAQTDVRQRE 1228

Query: 74   AE--AAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIET----ENQKLRETLEEYNK 127
             E     L  Y+   D         LG  LQ   +R   I+     ++Q +RE L +   
Sbjct: 1229 LEQLGRQLRYYRESAD--------PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQA 1280

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
               E++          EK+ E ++  K     I              K+ +LQ       
Sbjct: 1281 LLEEIERHG-------EKVEECQRFAKQYINAI--------------KDYELQLVTYKAQ 1319

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
             +   +  K   +Q+  E    E  DL+T Y E TT  +  I+ I   L R  +   +A+
Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379

Query: 248  REAETLREQLSSANHSLQLASQI------QKAPDVEQAIEVLTRSSLEVELAAKEREIAQ 301
            ++    RE+L+    +L+   Q+       KA    +A E+  R  ++ E+  +E     
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR--MQEEVVRREEAAVD 1437

Query: 302  LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG---QADYEEVKK-- 356
              +  + +Q  L +LR++S ++I    +Q  A   +  ++EE+++    Q +  E ++  
Sbjct: 1438 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497

Query: 357  ---ELNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARR 412
               EL  L++  E A ++    Q+ A+ L        R +Q E+   R +  +L+   + 
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERL-------RRQVQDESQRKRQAEVELASRVKA 1550

Query: 413  KGKDQPESRR 422
            + +   E +R
Sbjct: 1551 EAEAAREKQR 1560



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 91/424 (21%), Positives = 178/424 (41%), Gaps = 72/424 (16%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRK--QVAPLLKSFQGEID 65
            R K +++   T L  + +E++  +  L E+ +  K    E  R+  QV   L S + +++
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
             LSK     EA    +  R  D        +  + LQ + +++  +  E  +L    +E 
Sbjct: 2266 ELSKLKARIEAENRALILRDKD--------NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317

Query: 126  NK--EFAE---VKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             +  + AE    + + +  K LKEK++  ++  + +AE   L+++++L     E+ R+LQ
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ---EQARRLQ 2374

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E +     +L E   + Q  Q  LE  R    ++        +A+A+ +++ + ++ RA 
Sbjct: 2375 EDKEQMAQQLAE---ETQGFQRTLEAERQRQLEM--------SAEAERLKLRVAEMSRAQ 2423

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
             RAE    +A+  R+Q       L                          ELA +E+   
Sbjct: 2424 ARAE---EDAQRFRKQAEEIGEKLH-----------------------RTELATQEKVTL 2457

Query: 301  QLVEDVQRLQA--SLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
                ++QR Q+     +LRE     I++LE++           +EKL+ +A   ++K E 
Sbjct: 2458 VQTLEIQRQQSDHDAERLRE----AIAELERE-----------KEKLQQEAKLLQLKSEE 2502

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQP 418
                  E    E    Q +    +  LL++ R ++ E A L     D    A++  ++Q 
Sbjct: 2503 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2562

Query: 419  ESRR 422
              ++
Sbjct: 2563 RQQQ 2566



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 93/449 (20%), Positives = 185/449 (41%), Gaps = 68/449 (15%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPED-------LRKQVAPLLKSFQGEIDA 66
            +A  T+ +  Q E E +R+R +    E ++   E+         ++ A   K+   E++ 
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHD-IETENQKLRETLEEY 125
            L  + +EA        +RL +  +   A    +QLQL  +     ++ E +     +++ 
Sbjct: 2041 LKAKVEEA--------RRLRERAEQESA----RQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
             +E  +   QE   +++ +++R   +  +  AE  A E   + + + A+  R+++E +  
Sbjct: 2089 EQELQQTLQQE---QSVLDQLRGEAEAARRAAEE-AEEARVQAEREAAQSRRQVEEAERL 2144

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER------- 238
              S  E+A+ + Q+ Q A EK R E      +  +   A   + +    ++E+       
Sbjct: 2145 KQSAEEQAQARAQA-QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203

Query: 239  -ANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               Q+A+V Q E  TLR QL   +H   L  +  +    E       RS +E EL +   
Sbjct: 2204 TLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262

Query: 298  EIAQL------------------VEDVQR-LQASLTKLRE------------NSASQISQ 326
            ++ +L                   ++ QR LQ    K+++              A+++ Q
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322

Query: 327  LEQQLSAKNSTL--KQLEEKLKGQADYEEVKKELNILKSM-EFAPSEGAGTQDAAKPLEV 383
            L ++  A+   L  K L+EK++   +   +K E  +L+   E A  +    Q+  + +  
Sbjct: 2323 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382

Query: 384  LLLEKNRSLQSENAALRISNSDLSGSARR 412
             L E+ +  Q    A R    ++S  A R
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAER 2411



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 74/389 (19%), Positives = 162/389 (41%), Gaps = 53/389 (13%)

Query: 5    AGARLKRELDATATVLANR-QDESEQSRKRLIEQSREFKKNTPEDLRKQV-----APLLK 58
            A A L ++    A   A R Q++ EQ  ++L E+++ F++    + ++Q+     A  LK
Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413

Query: 59   SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN--- 115
                E+     R++E    F    K+  ++ + +   +L  Q ++ + +  +I+ +    
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFR---KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470

Query: 116  --QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE---------- 163
              ++LRE + E  +E  E   QE  +  LK +  +  Q  +   ET AL+          
Sbjct: 2471 DAERLREAIAELERE-KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529

Query: 164  -----------------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSL 200
                                   K Q+L+ +   +++++++ +    + +EEA  +    
Sbjct: 2530 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589

Query: 201  QTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
            +  + + + EL  L+ +  ++    A+E + +   L+   ++   A   +E +     +A
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA 2649

Query: 261  NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLV--EDVQRLQASLTKLRE 318
              +L         P  E   E  +   L  +++A+  + A ++  E++QRL    T + E
Sbjct: 2650 TKTLPNGRDALDGPAAEAEPE-HSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDE 2708

Query: 319  NSASQISQ--LEQQLSAKNSTLKQLEEKL 345
             +  +  +  L+ + S     LK   EKL
Sbjct: 2709 LARREDVRHYLQGRSSIAGLLLKATNEKL 2737



 Score = 32.3 bits (72), Expect = 3.5
 Identities = 57/265 (21%), Positives = 103/265 (38%), Gaps = 43/265 (16%)

Query: 114  ENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFA 173
            E QK +  +E   K  A +  +   + AL E            A T+  E E  L     
Sbjct: 1052 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEP--------SPAAPTLRSELELTLGK--L 1101

Query: 174  EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            E+ R L    +    KL+     ++  Q A E  R     LK    +   A   E+E   
Sbjct: 1102 EQVRSLSAIYLE---KLKTISLVIRGTQGAEEVLRAHEEQLKEA--QAVPATLPELEATK 1156

Query: 234  TDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELA 293
              L++   +AE  Q   + LR++L  A    ++  ++Q+                +VE+ 
Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQ---EVGERLQQ-----------RHGERDVEVE 1202

Query: 294  AKEREIAQLVEDVQRLQASLTKLRENSASQIS-------QLEQQLSAKNSTLKQLEEKLK 346
                 +AQL+E  Q + A  T +R+    Q+        +    L A     ++ +E+++
Sbjct: 1203 RWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261

Query: 347  ------GQADYEEVKKELNILKSME 365
                   QA  E++++E  +L+ +E
Sbjct: 1262 AMPLADSQAVREQLRQEQALLEEIE 1286


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 103/427 (24%), Positives = 191/427 (44%), Gaps = 49/427 (11%)

Query: 4    VAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKS---F 60
            VA  R K E DA       R +E E+++K+L ++ +E ++NT E    + A L K+    
Sbjct: 1372 VAQWRTKYETDAI-----QRTEELEEAKKKLAQRLQEAEENT-ETANSKCASLEKTKQRL 1425

Query: 61   QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120
            QGE++ L +  + +  A   + K+  +  D V A +  Q+L      L   + E++ L  
Sbjct: 1426 QGEVEDLMRDLERSHTACATLDKKQRNF-DKVLA-EWKQKLDESQAELEAAQKESRSLST 1483

Query: 121  TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQ 180
             L +    + EV +Q   ++ L+ + +  ++ + +  E IA E  + LQ   AEK +KL 
Sbjct: 1484 ELFKMRNAYEEVVDQ---LETLRRENKNLQEEISDLTEQIA-ETGKNLQE--AEKTKKLV 1537

Query: 181  ETQMSTTS-KLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERA 239
            E + S     LEE E  ++  ++ + + + EL  +K++ D +   K +EIE +  + +RA
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRA 1597

Query: 240  ---------------NQRAEVAQREAETLREQLSSANHSLQLASQIQK--------APDV 276
                           N    + ++    L E      HS +  ++ QK          D 
Sbjct: 1598 AEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDS 1657

Query: 277  EQAIEVLTRSS--LEVELAAKEREIAQLVEDVQRLQASL------TKLRENSASQISQLE 328
            +  ++   RS+  L+ +LA  ER    L+E+++ ++ +L       +L E      S   
Sbjct: 1658 QLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV 1717

Query: 329  QQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388
            Q L ++N++L   ++KL+      + + E +I +S            DAA   E L  E+
Sbjct: 1718 QLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ 1777

Query: 389  NRSLQSE 395
            + S   E
Sbjct: 1778 DTSAHLE 1784



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 104/447 (23%), Positives = 193/447 (43%), Gaps = 38/447 (8%)

Query: 11   RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKR 70
            +EL A    L   + E+E + +  IE+ R       E++ ++    L+   G   A  + 
Sbjct: 1113 KELQARIEEL-EEEIEAEHTLRAKIEKQRSDLARELEEISER----LEEASGATSAQIEM 1167

Query: 71   SKEAEAAFLNVYKRLID--VPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKE 128
            +K+ EA F  + + L +  +     A  L ++    V  L +     Q++++ LE+   E
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSE 1227

Query: 129  FA-EVKNQEVTIKAL---KEKIREYEQTLKNQAETIALEKEQKLQ--NDFAEKERKLQET 182
               E+ +    I+AL   K  I    +T+++Q   I  + EQ+ Q  +D   ++ +LQ  
Sbjct: 1228 LKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQ 1287

Query: 183  QMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK---ADEIEMIMTDLERA 239
                + ++EE E  +  L  + +    +L +LK + +EET AK   A  ++    D +  
Sbjct: 1288 NGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLL 1347

Query: 240  NQRAEVAQREAETLREQLSSANHSLQL------ASQIQKAPDVEQAIEVLTRSSLEVE-- 291
             ++ E  Q     L+  LS AN  +           IQ+  ++E+A + L +   E E  
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407

Query: 292  LAAKEREIAQLVEDVQRLQASLTKLR---ENSASQISQLEQQLSAKNSTLKQLEEKL-KG 347
                  + A L +  QRLQ  +  L    E S +  + L+++    +  L + ++KL + 
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467

Query: 348  QADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLS 407
            QA+ E  +KE   L S E      A  +         ++++  +L+ EN  L+   SDL+
Sbjct: 1468 QAELEAAQKESRSL-STELFKMRNAYEE---------VVDQLETLRRENKNLQEEISDLT 1517

Query: 408  GSARRKGKDQPESRRPGSLPAPPPSQL 434
                  GK+  E+ +   L     S L
Sbjct: 1518 EQIAETGKNLQEAEKTKKLVEQEKSDL 1544



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 84/403 (20%), Positives = 177/403 (43%), Gaps = 34/403 (8%)

Query: 8    RLKRELDAT-ATVLANRQDESE-QSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEID 65
            RL+    AT A +  N++ E+E Q  +R +E++    + T   LRK+ A  +     +ID
Sbjct: 1153 RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID 1212

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPAL-----DLGQQLQLKVQRLHDIETENQKLRE 120
             L +  ++ E     +   + D+   + AL     ++ +  +    +  +I+ ++++  +
Sbjct: 1213 NLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ 1272

Query: 121  TLEEYNKEFAEVKNQEVTI-------KALKEKIREYEQTLKNQAETIA--LEKEQKLQND 171
             + + N + A ++ Q   +       ++L  ++ + +Q L  Q E +   +E+E K +N 
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA 1332

Query: 172  FAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM 231
             A   +  +        + EE +     LQ AL K  +E+   +TKY+ +   + +E+E 
Sbjct: 1333 MAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1392

Query: 232  IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRS----- 286
                L    QR + A+   ET   + +S   + Q     +   +VE  +  L RS     
Sbjct: 1393 AKKKLA---QRLQEAEENTETANSKCASLEKTKQ-----RLQGEVEDLMRDLERSHTACA 1444

Query: 287  SLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLK 346
            +L+ +    ++ +A+  + +   QA L   ++ S S  ++L +  +A    + QLE   +
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504

Query: 347  GQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKN 389
               + +E   +L      E     G   Q+A K  +++  EK+
Sbjct: 1505 ENKNLQEEISDLT-----EQIAETGKNLQEAEKTKKLVEQEKS 1542



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 79/412 (19%), Positives = 173/412 (41%), Gaps = 64/412 (15%)

Query: 7    ARLKRELDATATVLAN---RQDESEQSRKRLIEQSREFKKNTPE------DLRKQVAPLL 57
            A +K + + T   LA    R+ E E+    L+++  + +           D  ++   L+
Sbjct: 854  ATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLI 913

Query: 58   KS---FQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL-----DLGQQLQLKVQRLH 109
            KS    + ++  L++R +E E     +  +  ++ D   +L     DL   L    +  H
Sbjct: 914  KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973

Query: 110  DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQT--------------LKN 155
              E + + L E +    +  +++  ++ +++   ++  +  Q               L+ 
Sbjct: 974  ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQ 1033

Query: 156  QAETI--ALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFD 213
            Q + +  +LE+E+KL+ D    +RKL+     +   + + E+  Q ++  L+K   EL  
Sbjct: 1034 QTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093

Query: 214  LKTKYDEETT------AKADEIEMIMTDLER------------ANQRAEVAQREAETLRE 255
            L+ K D+E         K  E++  + +LE               QR+++A RE E + E
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA-RELEEISE 1152

Query: 256  QLSSANHSLQLASQIQK---------APDVEQAI--EVLTRSSLEVELAAKEREIAQLVE 304
            +L  A+ +     ++ K           D+E+A      T ++L  + A    E+ + ++
Sbjct: 1153 RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID 1212

Query: 305  DVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQAD-YEEVK 355
            ++QR++  L K +     +I  +   + A + +   +E   +   D + E+K
Sbjct: 1213 NLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIK 1264



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 75/397 (18%), Positives = 165/397 (41%), Gaps = 60/397 (15%)

Query: 7    ARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQ--VAPLLKSFQGEI 64
            +++K ELD     +  + +E EQ ++     +   +     ++R +     L K  +G++
Sbjct: 1570 SQVKSELDRK---VIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626

Query: 65   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH--DIETENQKLRETL 122
            + +  +   +        K L  V           Q QLK  +LH  D    N+ L+E L
Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLRTV-----------QGQLKDSQLHLDDALRSNEDLKEQL 1675

Query: 123  EEYNKE----FAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERK 178
                +       E++  +V ++  +   R  EQ L + ++ + L   Q       +K+ +
Sbjct: 1676 AIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLE 1735

Query: 179  LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDL-----KTKYDEETTAKADE----I 229
                Q        E E+ +Q  + A EK +  + D      + K +++T+A  +     +
Sbjct: 1736 ADIAQCQA-----EVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790

Query: 230  EMIMTDLERANQRAEV-----AQREAETLREQLSSANHSLQL-----ASQIQKAPDVEQA 279
            E  + DL+     AE       +++ + L  ++    + L +     A  ++ A   E+ 
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERK 1850

Query: 280  IEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLK 339
            ++ +T  + E       + I +L + V +LQA +   +     Q  + E+Q + + S  +
Sbjct: 1851 VKEMTYQAEE-----DHKNILRLQDLVDKLQAKVKSYKR----QAEEAEEQANTQLSRCR 1901

Query: 340  QLEEKLKGQADYEEV-KKELNILKSMEFAPSEGAGTQ 375
            +++ +L+  A+  ++ + ++N L+    A S   G+Q
Sbjct: 1902 RVQHELEEAAERADIAESQVNKLR----AKSRDVGSQ 1934


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%)

Query: 47  EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106
           E LR QV  L    + +++ L  +  E +A    + K  I +          Q+ Q  +Q
Sbjct: 84  EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139

Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165
           R L +   E ++  E  E Y +E A+  +        KE   E  ++L+ + E +  E+ 
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 198

Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222
            +L  D    + +++E      +++ +L++ E +   L+ AL + R          D  +
Sbjct: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 248

Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281
           + K + +++    +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A   E+ +E
Sbjct: 249 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 307

Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341
           +LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL    + +++ 
Sbjct: 308 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 365

Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378
           +++++      ADY++ +KK   +   ++    E    Q+A+
Sbjct: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 407



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%)

Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 83  EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142

Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202

Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321
             L++              E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+
Sbjct: 203 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 248

Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378
           S+  +   L++ +  KN  L+ + ++       E +++EL+  +S      E       A
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 302

Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421
           + +  +L ++N +L+ +   LR +  DL        + Q  +R
Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 345



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 83  KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141
           +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795

Query: 142 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195
            L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855

Query: 196 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254
           +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%)

Query: 47  EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106
           E LR QV  L    + +++ L  +  E +A    + K  I +          Q+ Q  +Q
Sbjct: 198 EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253

Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165
           R L +   E ++  E  E Y +E A+  +        KE   E  ++L+ + E +  E+ 
Sbjct: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 312

Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222
            +L  D    + +++E      +++ +L++ E +   L+ AL + R          D  +
Sbjct: 313 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 362

Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281
           + K + +++    +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A   E+ +E
Sbjct: 363 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 421

Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341
           +LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL    + +++ 
Sbjct: 422 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 479

Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378
           +++++      ADY++ +KK   +   ++    E    Q+A+
Sbjct: 480 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 521



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%)

Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 197 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 256

Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 257 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 316

Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321
             L++              E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+
Sbjct: 317 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 362

Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378
           S+  +   L++ +  KN  L+ + ++       E +++EL+  +S      E       A
Sbjct: 363 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 416

Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421
           + +  +L ++N +L+ +   LR +  DL        + Q  +R
Sbjct: 417 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 459



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 83   KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141
            +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 855  EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 909

Query: 142  -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195
             L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 910  ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 969

Query: 196  KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254
            +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 970  RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1029


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%)

Query: 47  EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106
           E LR QV  L    + +++ L  +  E +A    + K  I +          Q+ Q  +Q
Sbjct: 84  EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139

Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165
           R L +   E ++  E  E Y +E A+  +        KE   E  ++L+ + E +  E+ 
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 198

Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222
            +L  D    + +++E      +++ +L++ E +   L+ AL + R          D  +
Sbjct: 199 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 248

Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281
           + K + +++    +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A   E+ +E
Sbjct: 249 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 307

Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341
           +LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL    + +++ 
Sbjct: 308 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 365

Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378
           +++++      ADY++ +KK   +   ++    E    Q+A+
Sbjct: 366 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 407



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%)

Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 83  EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142

Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 143 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 202

Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321
             L++              E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+
Sbjct: 203 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 248

Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378
           S+  +   L++ +  KN  L+ + ++       E +++EL+  +S      E       A
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 302

Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421
           + +  +L ++N +L+ +   LR +  DL        + Q  +R
Sbjct: 303 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 345



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 83  KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141
           +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 741 EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 795

Query: 142 -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195
            L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 796 ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 855

Query: 196 KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254
           +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 856 RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 915


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 78/342 (22%), Positives = 163/342 (47%), Gaps = 28/342 (8%)

Query: 47  EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106
           E LR QV  L    + +++ L  +  E +A    + K  I +          Q+ Q  +Q
Sbjct: 218 EGLRAQVRDL----EEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273

Query: 107 R-LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE 165
           R L +   E ++  E  E Y +E A+  +        KE   E  ++L+ + E +  E+ 
Sbjct: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALK-ERV 332

Query: 166 QKLQNDFAEKERKLQETQM---STTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222
            +L  D    + +++E      +++ +L++ E +   L+ AL + R          D  +
Sbjct: 333 DELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMR----------DLSS 382

Query: 223 TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281
           + K + +++    +E+ NQ  EV +++ E L+E+LS A  ++ +L  Q+  A   E+ +E
Sbjct: 383 SEKQEHVKLQKL-MEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 441

Query: 282 VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341
           +LT  +L +E   K RE+ + V D++ +     +L+EN+     +L +QL    + +++ 
Sbjct: 442 MLTDRNLNLE--EKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREA 499

Query: 342 EEKLKGQ----ADYEE-VKKELNILKSMEFAPSEGAGTQDAA 378
           +++++      ADY++ +KK   +   ++    E    Q+A+
Sbjct: 500 QKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEAS 541



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 70/283 (24%), Positives = 129/283 (45%), Gaps = 24/283 (8%)

Query: 143 KEKIREYEQTLKNQAETIALEK-EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQ 201
           +E +R   + L+ + ET+ L++ E K +    EK +   E      SK++E +  +Q   
Sbjct: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276

Query: 202 TALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSAN 261
               K   E  + K +Y EE    AD IEM   D E A +RAE  Q+E E L+E++    
Sbjct: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELT 336

Query: 262 HSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSA 321
             L++              E+  + S   + AA   ++ QL E   RL+ +L ++R+ S+
Sbjct: 337 TDLEILK-----------AEIEEKGS---DGAASSYQLKQLEEQNARLKDALVRMRDLSS 382

Query: 322 SQISQ---LEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAA 378
           S+  +   L++ +  KN  L+ + ++       E +++EL+  +S      E       A
Sbjct: 383 SEKQEHVKLQKLMEKKNQELEVVRQQ------RERLQEELSQAESTIDELKEQVDAALGA 436

Query: 379 KPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESR 421
           + +  +L ++N +L+ +   LR +  DL        + Q  +R
Sbjct: 437 EEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENAR 479



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 13/180 (7%)

Query: 83   KRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKA- 141
            +++   P   P   L Q   + +  ++ + T  Q+      EY+ E    K   V ++A 
Sbjct: 875  EQIYGTPSSSPYECLRQSCNILISTMNKLATAMQE-----GEYDAERPPSKPPPVELRAA 929

Query: 142  -LKEKIREYEQT-LK-NQAETIALEKEQKLQ---NDFAEKERKLQETQMSTTSKLEEAEH 195
             L+ +I + E   LK    ET+  E ++ L+    + +E   +L   +    S  ++A+ 
Sbjct: 930  ALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADE 989

Query: 196  KVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA-EVAQREAETLR 254
            +++ +QT LE+T+  L   + +++E   A   +I+ +  +     QR    ++R  E LR
Sbjct: 990  RIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLR 1049



 Score = 31.6 bits (70), Expect = 6.0
 Identities = 35/163 (21%), Positives = 62/163 (38%), Gaps = 9/163 (5%)

Query: 1350 ADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASAT 1409
            ADT  P++   +  + + R    T    S   G    +           P P    ++  
Sbjct: 101  ADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGV 160

Query: 1410 ATAAP-------AAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGL 1462
            A A+        A+  + ++S  + P + P A    P P  +S  + P  PS  +   GL
Sbjct: 161  AGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGL 220

Query: 1463 PEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPI-EWE 1504
                   + +   LR K+A +  + +  LEK   + E + EW+
Sbjct: 221  RAQVRDLEEKLETLRLKRAED-KAKLKELEKHKIQLEQVQEWK 262


>gi|122937424 one cut homeobox 3 [Homo sapiens]
          Length = 494

 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 59/201 (29%), Positives = 93/201 (46%), Gaps = 30/201 (14%)

Query: 1121 AMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGRE 1180
            A + E++T  + +R+   L   ++ Q +F + IL  +QG++SDLL  PKPW KL   GRE
Sbjct: 316  AAAEEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLK-SGRE 374

Query: 1181 PFVRMQLWLNDPNNVEKLMDMKRME--KKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASP 1238
             F RM  WL +P       + +RM   + A  KR+       +  +P             
Sbjct: 375  TFRRMWKWLQEP-------EFQRMSALRLAACKRKEQEQQKERALQP------------- 414

Query: 1239 QPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSR 1298
                  KK R+V    ++  L   +++   PS +    ++ QL L+ +TV N+F N R R
Sbjct: 415  ------KKQRLVFTDLQRRTLIAIFKENKRPSKEMQVTISQQLGLELNTVSNFFMNARRR 468

Query: 1299 IRRELFIEEIQAGSQGQAGAS 1319
                 + EE      G AGA+
Sbjct: 469  CMNR-WAEEPSTAPGGPAGAT 488



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 36/98 (36%), Positives = 63/98 (64%), Gaps = 5/98 (5%)

Query: 541 SAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLT 600
           SAG+ +E  E++T E+A+++  +L +++I Q IF   +L  SQG++S++L  PKPW+KL 
Sbjct: 313 SAGAAAE--EINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKLK 370

Query: 601 VRGKEPFHKMKQFLSDE--QNILALRSIQGRQRENPGQ 636
             G+E F +M ++L +   Q + ALR    +++E   Q
Sbjct: 371 -SGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEQQ 407



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 30/66 (45%), Positives = 46/66 (69%), Gaps = 1/66 (1%)

Query: 941  QEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFI 1000
            +E++T E+ +++  +L +  I Q IF +++L  SQG++SD+L  PKPWSKL + GRE F 
Sbjct: 319  EEINTKEVAQRITAELKRYSIPQAIFAQRILCRSQGTLSDLLRNPKPWSKL-KSGRETFR 377

Query: 1001 RMQLWL 1006
            RM  WL
Sbjct: 378  RMWKWL 383


>gi|24307887 one cut homeobox 1 [Homo sapiens]
          Length = 465

 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 58/205 (28%), Positives = 95/205 (46%), Gaps = 30/205 (14%)

Query: 1125 ELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVR 1184
            E++T  + +R+   L   ++ Q +F + +L  +QG++SDLL  PKPW KL   GRE F R
Sbjct: 291  EINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLK-SGRETFRR 349

Query: 1185 MQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQL 1244
            M  WL +P    +   M  +   A  ++      D              +G +P      
Sbjct: 350  MWKWLQEP----EFQRMSALRLAACKRKEQEHGKD--------------RGNTP------ 385

Query: 1245 KKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELF 1304
            KKPR+V    ++  L   +++   PS +    ++ QL L+ STV N+F N R R      
Sbjct: 386  KKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRR-----S 440

Query: 1305 IEEIQAGSQGQAGASDSPSARSGRA 1329
            +++ Q      +G S S S+   +A
Sbjct: 441  LDKWQDEGSSNSGNSSSSSSTCTKA 465



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 57/200 (28%), Positives = 97/200 (48%), Gaps = 32/200 (16%)

Query: 531 GMAPSPSQSESAGSVSEG------EEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQG 584
           G A  P+ S +   VS G      EE++T E+A+++  +L +++I Q IF   VL  SQG
Sbjct: 266 GTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQG 325

Query: 585 SVSEILARPKPWNKLTVRGKEPFHKMKQFLSDE--QNILALR--------SIQGRQRENP 634
           ++S++L  PKPW+KL   G+E F +M ++L +   Q + ALR           G+ R N 
Sbjct: 326 TLSDLLRNPKPWSKLK-SGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNT 384

Query: 635 GQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQV---------Q 685
            +    +F +V +R       +    + ++  S E   +I +Q   EL           +
Sbjct: 385 PKKPRLVFTDVQRR------TLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARR 438

Query: 686 KTAEPAQPSSASGSGNSDDA 705
           ++ +  Q   +S SGNS  +
Sbjct: 439 RSLDKWQDEGSSNSGNSSSS 458



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 31/66 (46%), Positives = 46/66 (69%), Gaps = 1/66 (1%)

Query: 941  QEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFI 1000
            +E++T E+ +++  +L +  I Q IF ++VL  SQG++SD+L  PKPWSKL + GRE F 
Sbjct: 290  EEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKL-KSGRETFR 348

Query: 1001 RMQLWL 1006
            RM  WL
Sbjct: 349  RMWKWL 354


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 178/831 (21%), Positives = 333/831 (40%), Gaps = 127/831 (15%)

Query: 9    LKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL------LKSFQG 62
            L+++ +    VL ++  E E+      +Q  E ++   +DL+KQ+  L      L+    
Sbjct: 1513 LEKDRETQRNVLEHQLLELEKK-----DQMIESQRGQVQDLKKQLVTLECLALELEENHH 1567

Query: 63   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDL---GQQLQLKVQRLHDIETENQKLR 119
            +++   K  KE E         L  +      LDL    Q+LQ +  ++HD+E+ +  L 
Sbjct: 1568 KMECQQKLIKELEGQRETQRVALTHL-----TLDLEERSQELQAQSSQIHDLESHSTVLA 1622

Query: 120  ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE-------------- 165
              L+E ++   EVK+Q   I+ L+ +     Q L+ + + + L+KE              
Sbjct: 1623 RELQERDQ---EVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTK 1679

Query: 166  ------QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYD 219
                  ++++    E+ R+L   +     + EE +   ++ + +LE  +  L D + + +
Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE 1739

Query: 220  ------EETTAKADEIEMIMTDLER--ANQRAEVAQREAE--TLREQLSSANHSLQLASQ 269
                   E     D++E  +  L R        ++QRE E   L++QL  A    +L  Q
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799

Query: 270  IQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVED-VQRLQASLTKLRENSASQISQLE 328
              ++  +++A   L +   E+E   +E++ AQ  E+ V+    +L    E +   + +  
Sbjct: 1800 SLQS-QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858

Query: 329  QQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388
             +L       ++LEE+L  +    +  +E  +L  +    +E    + A   L+    E+
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEE--VLGDLR---AESREQEKALLALQQQCAEQ 1913

Query: 389  NRSLQSENAALRISNSDLSGSARRKGKDQP-ESRRPGSLPAPPPSQLPRNPGEQASNTNG 447
             +  + E  AL+  +S L   A  K +DQ  E+ R  S  +    +  R   E      G
Sbjct: 1914 AQEHEVETRALQ--DSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971

Query: 448  THQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQL-MQSFYSKAMQEAGSTSMI 506
                +  G  Q     +  S SL        A  + LQ  L     +S+ ++EA    + 
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLE-------ASTATLQASLDACQAHSRQLEEA----LR 2020

Query: 507  FSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLI- 565
               G      +  Q  +QQ            + E      E E++    +A++V+E +I 
Sbjct: 2021 IQEGEIQDQDLRYQEDVQQLQQA-----LAQRDEELRHQQEREQLLEKSLAQRVQENMIQ 2075

Query: 566  -KHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALR 624
             K N+GQ      + GL Q SV E+        +LT+  K            EQ IL LR
Sbjct: 2076 EKQNLGQEREEEEIRGLHQ-SVREL--------QLTLAQK------------EQEILELR 2114

Query: 625  SIQGRQREN----PGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAK- 679
              Q  QR N    P        +E   + +  E  +   +        E +++ L Q + 
Sbjct: 2115 ETQ--QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQREL--------ERLQAALRQTEA 2164

Query: 680  RELQVQKTAEPAQPSSA--SGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSD 737
            RE++ ++ A+    S A    S +S   +   LQ +  E +++Q  L   L+    +   
Sbjct: 2165 REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEK 2224

Query: 738  ITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEA 788
              + +P   ST+ +    S     + L + S     G  A P+P  ++K++
Sbjct: 2225 ERLHSPGATSTAEL---GSRGEQGVQLGEVS-----GVEAEPSPDGMEKQS 2267



 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 173/780 (22%), Positives = 310/780 (39%), Gaps = 88/780 (11%)

Query: 10   KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK-----SFQGEI 64
            +R+  A  TV    + +S    + L++++RE  +   E L ++   L +       QG+ 
Sbjct: 443  ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD- 501

Query: 65   DALSKRSKEAEAAFLNVYKR-----LIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 119
             A  ++ ++ E   L V +R     ++   +   +  L + + L+ + L     E + LR
Sbjct: 502  SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR-EALESSHLEGELLR 560

Query: 120  E-------TLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEK----EQKL 168
            +        L    +  AE+ + E T+K     +R     L    E +AL+K    +Q L
Sbjct: 561  QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLL 620

Query: 169  QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTAL---EKTRTELFDLKTKYDEETTAK 225
            Q         L+E   S  S++E AE    +LQ  L   EK R  L++  T  + +    
Sbjct: 621  Q---------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671

Query: 226  ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDV------EQ 278
             +    +  DL    +  E  Q++    R Q  +A   L QL  + ++  +V      E+
Sbjct: 672  EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK 731

Query: 279  AIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTL 338
               V  +++LEV L A ER+   L E +Q     L+  +E   S + + +QQ S    T 
Sbjct: 732  EALVREKAALEVRLQAVERDRQDLAEQLQ----GLSSAKELLESSLFEAQQQNSVIEVTK 787

Query: 339  KQLEEKLKGQADYEEV-KKELNILK-SMEFAPSEGAGTQD-AAKPLEVLLLEKNRSLQSE 395
             QLE +++     +EV + E+  LK  ++   S+    +D AA+ L     E   +L+ +
Sbjct: 788  GQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQ 847

Query: 396  NAALRISNSDLSGS-ARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPA 454
             AA     + L     + +   Q E  +          +L     EQ +           
Sbjct: 848  KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE 907

Query: 455  GLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMI------FS 508
              +Q    S+L    L         L +LLQ Q   +  S+ ++       +       +
Sbjct: 908  ERTQ--AESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQET 965

Query: 509  TGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHN 568
            TG   T    +Q  L+++   +    +  Q ES+  +   ++MD  +    +K QL+  +
Sbjct: 966  TGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ--DKMDLQKQVEDLKSQLVAQD 1023

Query: 569  IGQRIFGHYV---LGLSQ--GSVSEILARPKPWNKLTVRGKEPFHKMKQFLSD--EQNIL 621
              QR+    V   L  +Q    + + L R K    L++  KE    + Q      +Q + 
Sbjct: 1024 DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELS 1083

Query: 622  ALR----SIQGRQRENPGQSLNRLFQEVPKRRN---GSEGNITTRIRASETGSDEAIKSI 674
            ALR      QG Q+E   Q +  L QEV ++       E  +   + AS     +   S+
Sbjct: 1084 ALRQDMQEAQGEQKELSAQ-MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL 1142

Query: 675  LEQAKRELQVQ---KTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQA 731
              Q  +  Q+Q   ++ E    + A+     + A          + +AQ A+L  AL+QA
Sbjct: 1143 WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA----------QAQAQLASLYSALQQA 1192



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 107/456 (23%), Positives = 199/456 (43%), Gaps = 75/456 (16%)

Query: 7    ARLKRELDATATVLANRQD---ESEQSRKRLIEQSREFKKNTPE------DLRKQVAPLL 57
            A+L++  +A A + A+ +D   E E+ +K+L E   + +  T +      + ++Q   L 
Sbjct: 666  AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725

Query: 58   KSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQK 117
            ++ Q E +AL +     E     V +   D+ + +  L   ++L      L + + +N  
Sbjct: 726  RAVQ-EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL--ESSLFEAQQQNSV 782

Query: 118  LRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKER 177
            +     E  K   EV+ Q VT    KE I+   + LK + +T   + EQ  + D A ++ 
Sbjct: 783  I-----EVTKGQLEVQIQTVT--QAKEVIQGEVRCLKLELDTERSQAEQ--ERDAAARQL 833

Query: 178  KLQETQMSTTSKLEEAEHKV-----------------QSLQTALEKTRTELFDLKTKYDE 220
               E +  T  + ++A H+                  Q L  ALE    E  +L+ +  E
Sbjct: 834  AQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKE 893

Query: 221  ETTAKADEIEMIMTDLERANQRAEVA--QREAETLREQLSSANHSLQLASQIQKAPD--- 275
            + T    E+E I    E    +AE A  Q + ET +E++S     LQ   ++  A     
Sbjct: 894  QQT----EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLE 949

Query: 276  -------VEQAIEVLTRSSLEVELAAKEREIAQLV----EDVQRLQ---ASLTKLRENSA 321
                   V++  E  T   L+ +L   +RE+ +      +D+  LQ   +SL + + +  
Sbjct: 950  RLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQ 1009

Query: 322  SQISQLEQQLSAKNSTLK----QLEEKLKGQADYEEVKKELNILK-SMEFAPSEGAGTQD 376
             Q+  L+ QL A++ + +    +++EKL+   +Y  ++KEL   K S+  +  E      
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME------ 1063

Query: 377  AAKPLEVLLLEKNRSL-QSENAALRISNSDLSGSAR 411
              K   +L+L++  S+ Q E +ALR    +  G  +
Sbjct: 1064 --KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQK 1097



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 149/735 (20%), Positives = 289/735 (39%), Gaps = 96/735 (13%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE--DLRKQVAPLLKSFQGEID 65
            +L ++L  T       +D+ ++  +RL +   E  +   E  DL++Q    L   Q E  
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ----LSQNQEEKS 1302

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
                +    E+  + +++ +  +   +   +L Q+++ + +R   ++   + L   +E  
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAEL-QRMEAQGER-ELLQAAKENLTAQVEHL 1360

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE--QKLQNDFAEKE---RKLQ 180
                 E + Q      L+E +R     LK + E +  E+E  Q LQ     K    + LQ
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
            E     T  L E E +V++L       R ++ +L+ + + +  A    +E++  DL++ N
Sbjct: 1421 ENLALLTQTLAEREEEVETL-------RGQIQELEKQREMQKAA----LELLSLDLKKRN 1469

Query: 241  QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
            Q  ++ Q + + L +  S   H L +A Q     + EQ + V      E+E   K+RE  
Sbjct: 1470 QEVDLQQEQIQELEKCRSVLEH-LPMAVQ-----EREQKLTVQREQIRELE---KDRETQ 1520

Query: 301  QLVEDVQRLQ-ASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELN 359
            + V + Q L+     ++ E+   Q+  L++QL        +LEE      ++ +++ +  
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE------NHHKMECQQK 1574

Query: 360  ILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPE 419
            ++K +E    +    + A   L + L E+++ LQ++++ +     DL   +    ++  E
Sbjct: 1575 LIKELE---GQRETQRVALTHLTLDLEERSQELQAQSSQIH----DLESHSTVLARELQE 1627

Query: 420  SRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFA 479
                         Q  ++  EQ        +     L +      L    + +    +  
Sbjct: 1628 R-----------DQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676

Query: 480  LNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQS 539
               +L+  L Q     +++E G               +++Q  L Q     G  PS +Q 
Sbjct: 1677 QTKILEEDLEQ--IKLSLRERG-------------RELTTQRQLMQERAEEGKGPSKAQR 1721

Query: 540  ESAGSV------SEGE---EMDTAEIARQVKEQLIKHNIG-QRIFGHYVLGLSQGSVSEI 589
             S   +       E E   + +     +++K+QL +   G  R  G   L LSQ    EI
Sbjct: 1722 GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE-QEI 1780

Query: 590  LARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRR 649
            +   +   +   +G+     ++  L + Q  LA R           Q L  L QE  ++ 
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD----------QELEALQQE-QQQA 1829

Query: 650  NGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSI 709
             G E  +  +  A + G+ E     L++   ELQ  K          +  G    A+  +
Sbjct: 1830 QGQEERVKEKADALQ-GALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888

Query: 710  LQQARREMEAQQAAL 724
            L   R E   Q+ AL
Sbjct: 1889 LGDLRAESREQEKAL 1903



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 90/433 (20%), Positives = 171/433 (39%), Gaps = 46/433 (10%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLL---KSFQGEI 64
            R+++EL+     L     E EQ R  +++++   ++     LR+ +       K    ++
Sbjct: 1045 RIQKELEREKASLTLSLMEKEQ-RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103

Query: 65   DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 124
            + L +  KE EA FL    +L++  +     +   +  L  Q     + +  +LR T  +
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ-LRLRSTESQ 1162

Query: 125  YNKEFAEVK--NQEVTIKALKEKIREYEQTLKNQAETI--------------ALEKEQKL 168
                 AE +  NQ      L       +Q L +  E+                LE +Q  
Sbjct: 1163 LEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNG 1222

Query: 169  QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADE 228
                 ++   L  T +S  + +  A HK+       ++TR  L D   K +E  T    E
Sbjct: 1223 ARSLFKRGPLL--TALSAEA-VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE 1279

Query: 229  IEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEV-LTRSS 287
               + T+L+   ++    Q E      + +S      L S++ +  +   +++  L R+ 
Sbjct: 1280 KSQVHTELQDLQRQLSQNQEEKSKWEGKQNS------LESELMELHETMASLQSRLRRAE 1333

Query: 288  LEVELAAKEREIAQ-----LVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 342
            L+   A  ERE+ Q     L   V+ LQA++ + R   AS    LE+ L    S LK   
Sbjct: 1334 LQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARA-QASAAGILEEDLRTARSALKLKN 1392

Query: 343  EKLKGQADYEEVKKELNILK---------SMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQ 393
            E+++ + +  +  +E   LK         ++       A  ++  + L   + E  +  +
Sbjct: 1393 EEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE 1452

Query: 394  SENAALRISNSDL 406
             + AAL + + DL
Sbjct: 1453 MQKAALELLSLDL 1465



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 92/424 (21%), Positives = 179/424 (42%), Gaps = 65/424 (15%)

Query: 10   KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSK 69
            K   DA+  +   RQD   Q  K   +++    +   ++ ++++    +  + ++ AL +
Sbjct: 939  KELADASQQLERLRQDMKVQKLKE--QETTGILQTQLQEAQRELKEAARQHRDDLAALQE 996

Query: 70   RSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQ-KLRETLEEYNKE 128
             S       +++ K++ D+   + A D  Q+L         +E E Q KLRET +EYN+ 
Sbjct: 997  ESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL---------VEQEVQEKLRET-QEYNRI 1046

Query: 129  FAEVKNQEVTIK-ALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
              E++ ++ ++  +L EK  E    +  +A++I  ++   L+ D                
Sbjct: 1047 QKELEREKASLTLSLMEK--EQRLLVLQEADSIRQQELSALRQD---------------- 1088

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEM--IMTDLERAN---QR 242
              ++EA+ + + L   +E  R E+ + +  +  +     +E+E   I     RA+   Q 
Sbjct: 1089 --MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146

Query: 243  AEVAQ-----REAETLREQLSSANH-SLQLASQIQKA---PDVEQAIEVLTRSSLEVELA 293
            A+ AQ     R  E+  E L++      Q  +Q Q A     ++QA+  +  S  E+   
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGG 1206

Query: 294  AKEREIAQLVEDVQRLQASLTK--------LRENSASQISQLEQQLSAKNST-------L 338
                     +E  Q    SL K          E  AS + +L Q L     T       +
Sbjct: 1207 GDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQV 1266

Query: 339  KQLEEKLKG-QADYEEVKKEL-NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSEN 396
            ++LEE+L   +A+  +V  EL ++ + +     E +  +     LE  L+E + ++ S  
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQ 1326

Query: 397  AALR 400
            + LR
Sbjct: 1327 SRLR 1330


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 107/444 (24%), Positives = 214/444 (48%), Gaps = 62/444 (13%)

Query: 7   ARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEID- 65
           A  KR++  T   L  +++E  Q R R+ + + +      E+LR+Q     ++   E++ 
Sbjct: 367 AETKRQMHET---LEMKEEEIAQLRSRIKQMTTQ-----GEELREQKEKSERAAFEELEK 418

Query: 66  ALSKRSKEAEA-----AFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI--ETENQKL 118
           ALS   K  EA     A ++   + I+       + L Q+L    Q + D+  ++  +++
Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI 478

Query: 119 RETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLK-----NQAETIALEKEQKLQNDFA 173
            +  + + KE A  K QE+T K L+ + RE+++ +K     +Q+E + + +E++ Q   A
Sbjct: 479 AKLQKLHEKELAR-KEQELT-KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA 536

Query: 174 EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIM 233
            +E +LQ+  + T     E+E+K++ LQ   E  RT + +L++  ++      ++ + + 
Sbjct: 537 LEELELQKKAILT-----ESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591

Query: 234 TDLERANQR--------AEVAQREAETLREQLSSA-NHSLQLASQIQKAPDVEQAIEVLT 284
             LE    +         E  + E E+L+ Q  +     LQ+  Q Q   ++E+  E   
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQ-QYQTEMEKLRE--- 647

Query: 285 RSSLEVELAAKEREI---AQLVE----DVQRLQASLTKLRENSASQISQ-------LEQQ 330
           +   E E   K++EI   A + E     +++L    T+L E+ +S++S+       LE++
Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL-ESLSSELSEVLKARHKLEEE 706

Query: 331 LSA-KNSTLK---QLEEKLKGQADYEEVKKELNILKSMEFA-PSEGAGTQDAAKPLEVLL 385
           LS  K+ T K   +LE K+  Q ++ + + + +I+K  E +        +D    LE+LL
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVD-SIIKEHEVSIQRTEKALKDQINQLELLL 765

Query: 386 LEKNRSLQSENAALRISNSDLSGS 409
            E+++ L+   A +    +D+  S
Sbjct: 766 KERDKHLKEHQAHVENLEADIKRS 789



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 101/437 (23%), Positives = 189/437 (43%), Gaps = 43/437 (9%)

Query: 18   TVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAA 77
            T +   +++ EQ ++ L++      +   E++ ++    L   Q E+++LS    E   A
Sbjct: 640  TEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKA 699

Query: 78   FLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEV 137
               + + L  + D    +    + ++  Q+ H      Q++   ++E+     EV  Q  
Sbjct: 700  RHKLEEELSVLKDQTDKMKQELEAKMDEQKNH----HQQQVDSIIKEH-----EVSIQR- 749

Query: 138  TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197
            T KALK++I        NQ E +  E+++ L+   A  E  L+     +  +L++A  K+
Sbjct: 750  TEKALKDQI--------NQLELLLKERDKHLKEHQAHVEN-LEADIKRSEGELQQASAKL 800

Query: 198  QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257
               Q+    T  +     TK  EE  A+  + +++  + ER     +VA+ EA+      
Sbjct: 801  DVFQSYQSATHEQ-----TKAYEEQLAQLQQ-KLLDLETERILLTKQVAEVEAQKKDVCT 854

Query: 258  SSANHSLQ---LASQIQKA-PDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASL 313
                H +Q   L  Q++K   ++EQ ++ LT+   E +L    +E  Q  + +   +  +
Sbjct: 855  ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV-YESKLEDGNKEQEQTKQILVEKENMI 913

Query: 314  TKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAG 373
             ++RE    +I  L Q+LSAK  ++  L E      +YE   K  N  K ME    +   
Sbjct: 914  LQMREGQKKEIEILTQKLSAKEDSIHILNE------EYE--TKFKNQEKKMEKVKQKAKE 965

Query: 374  TQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQ 433
             Q+  K  ++L  E     + EN AL +S  +   +A  K  +  ++   G   A   S+
Sbjct: 966  MQETLKK-KLLDQEAKLKKELENTALELSQKEKQFNA--KMLEMAQANSAGISDA--VSR 1020

Query: 434  LPRNPGEQASNTNGTHQ 450
            L  N  EQ  +    H+
Sbjct: 1021 LETNQKEQIESLTEVHR 1037



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 96/446 (21%), Positives = 190/446 (42%), Gaps = 62/446 (13%)

Query: 2   LCVAGARLKRELDATATVLANRQDESEQSRKRLIEQ---SREFKKNTPEDLRKQVAP--- 55
           L  A   L+RE      +L+  QD+S +    L E+    ++ KK+  E+    +     
Sbjct: 160 LVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQ 219

Query: 56  LLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETEN 115
            +   Q ++  L +R +      +NV     DV  P+P L+   ++  K           
Sbjct: 220 YISVLQTQVSLLKQRLRNGP---MNV-----DVLKPLPQLEPQAEVFTK----------- 260

Query: 116 QKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ--------- 166
               E  E   +   E      T++ L+++++  E  LK   ETI   KEQ         
Sbjct: 261 ---EENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317

Query: 167 KLQNDFAEKER---KLQETQMSTTSK----LEEAEHKVQSLQ----TALEKTRTELFDLK 215
            LQ    E+ +   K+++  M+  +K    L +A++ ++ L+      + +T+ ++ +  
Sbjct: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377

Query: 216 TKYDEETTAKADEIEMIMTDLERANQRAEVAQREA-ETLREQLSSANHSLQLASQIQKAP 274
              +EE       I+ + T  E   ++ E ++R A E L + LS+A  + +   +++   
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437

Query: 275 DVE-QAIEVLT---RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQ 330
           D + + IE  +   R SL+ EL+  ++E+  +++  +  +  + KL++    ++++ EQ+
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK--KSSEEQIAKLQKLHEKELARKEQE 495

Query: 331 LSAKNSTLKQLEEKLKGQADYEEVKKELNILK-SMEFAPSEGAGTQDAAKPLEVLLLE-- 387
           L+ K   L+  E + + Q      K +   LK S E    E    ++     + +L E  
Sbjct: 496 LTKK---LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESE 552

Query: 388 -KNRSLQSENAALRISNSDLSGSARR 412
            K R LQ E    R    +L  S  +
Sbjct: 553 NKLRDLQQEAETYRTRILELESSLEK 578



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 100/439 (22%), Positives = 185/439 (42%), Gaps = 64/439 (14%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKK---NTPEDLRKQV----APLLKSF 60
            + K +      V    ++  E  +K+L++Q  + KK   NT  +L ++     A +L+  
Sbjct: 948  KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007

Query: 61   Q----GEIDALSK---RSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDI-- 111
            Q    G  DA+S+     KE   +   V++R ++    +    L QQ + ++Q +H+I  
Sbjct: 1008 QANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE-ELQEIHEIQL 1066

Query: 112  ---ETENQKLRETL-------EEYNKEFAEVKN----QEVTIKALKEKIREYEQTLKN-- 155
               E E  +L++ +       EE NKE   +K     Q+ T+  L+E++++    + +  
Sbjct: 1067 QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLA 1126

Query: 156  QAETIALEKEQKLQNDFAEKERK---LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELF 212
            Q ET      +KL+ D  +  ++   LQE  +      EE + KV  L + L+ T  E  
Sbjct: 1127 QDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQ 1186

Query: 213  DLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQK 272
             LK+ +++   +  D+        E    + ++  ++ E L E  +  N  + ++S    
Sbjct: 1187 SLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE--AKTNELINISSSKTN 1244

Query: 273  APDVEQAIEVLTRSSLEVELAAKEREIAQLVE--DVQRLQASLTKLRENSAS---QISQL 327
            A        +L+R S       K +E A L++   V  L+A L +L E   +      Q 
Sbjct: 1245 A--------ILSRISHCQHRTTKVKE-ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295

Query: 328  EQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLE 387
              QL  K + +K +      +AD E +  E   L+       EG   Q AA   E  + +
Sbjct: 1296 THQLEEKENQIKSM------KADIESLVTEKEALQ------KEGGNQQQAASEKESCITQ 1343

Query: 388  KNRSLQSENAALRISNSDL 406
              + L     A+ +   +L
Sbjct: 1344 LKKELSENINAVTLMKEEL 1362



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 75/311 (24%), Positives = 147/311 (47%), Gaps = 46/311 (14%)

Query: 101  LQLKVQRLHDIETENQKL---RETLEEYNKEF-AEVKNQEVTIKALKEKIREYEQTLKNQ 156
            LQ++  +  +IE   QKL    +++   N+E+  + KNQE  ++ +K+K +E ++TLK +
Sbjct: 914  LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK 973

Query: 157  AETIALEKEQKLQNDFAEKERKLQETQMSTTSK-LEEAEHKVQSLQTALEKTRTELFDLK 215
                 L++E KL+ +      +L + +    +K LE A+     +  A+ +  T   + K
Sbjct: 974  ----LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLET---NQK 1026

Query: 216  TKYDEETTAKADEIEMIMTDLE-RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAP 274
             + +  T     E+  +++  E + NQ+AE  Q              H +QL  + Q+  
Sbjct: 1027 EQIESLTEVHRRELNDVISIWEKKLNQQAEELQE------------IHEIQLQEKEQEVA 1074

Query: 275  DVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAK 334
            +++Q I +      E+      +EI  L E+  +   +L +L+E       QL+Q+ SA 
Sbjct: 1075 ELKQKILLFGCEKEEM-----NKEITWLKEEGVKQDTTLNELQE-------QLKQK-SAH 1121

Query: 335  NSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQS 394
             ++L Q E KLK   +    K E+++ KS++    E    Q+    L++L  E  R +  
Sbjct: 1122 VNSLAQDETKLKAHLE----KLEVDLNKSLK----ENTFLQEQLVELKMLAEEDKRKVSE 1173

Query: 395  ENAALRISNSD 405
              + L+ ++ +
Sbjct: 1174 LTSKLKTTDEE 1184



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 91/414 (21%), Positives = 175/414 (42%), Gaps = 81/414 (19%)

Query: 26   ESEQSRKRLIEQS-REFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKR 84
            ES QS   ++ +S +     T ++       + K+++ +I  L +   E E     V + 
Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758

Query: 85   LIDVPDPVPALDLGQQLQLKVQRLHDIETENQK-------LRETLEEYNKEFAEVKNQEV 137
              +        ++  Q Q ++ +L   E +  +       L+E LEE NK+++ +  Q V
Sbjct: 1759 KEETVSS--HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV 1816

Query: 138  TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197
              +  K  I                + +Q L+N F + ++ LQE +++     +  E K+
Sbjct: 1817 EKEGGKNNI----------------QAKQNLENVFDDVQKTLQEKELTC----QILEQKI 1856

Query: 198  QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257
            + L + L + +    ++     EE T+K ++++ +   ++  N+  E+ +   E      
Sbjct: 1857 KELDSCLVRQK----EVHRVEMEELTSKYEKLQALQ-QMDGRNKPTELLEENTEE----- 1906

Query: 258  SSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLR 317
             S +H +Q        P +   +E    + LE +LA  ERE  +L +++ RLQ  L  LR
Sbjct: 1907 KSKSHLVQ--------PKLLSNMEA-QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957

Query: 318  ---------------ENSASQISQLEQQLSAK-NSTLKQLEEKLKGQADYEEVKKELNIL 361
                           +    +I Q ++ L  K NSTLKQL  +   Q   +E + E+ I 
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017

Query: 362  KSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALR---ISNSDLSGSARR 412
            +           T + A+ +E  LLE ++  +  N  L+     + DL  +A+R
Sbjct: 2018 E-----------TINKAQEVEAELLESHQ--EETNQLLKKIAEKDDDLKRTAKR 2058



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 81/367 (22%), Positives = 161/367 (43%), Gaps = 51/367 (13%)

Query: 13   LDATATVLANRQDESEQSRKRLIEQSRE--FKKNTPEDLRKQVAPLLKSFQGEIDALSKR 70
            L      +++ + + ++ +  L++Q ++  FK +T   L K+    L+      +  S+ 
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT---LSKEKISALEQVDDWSNKFSEW 1445

Query: 71   SKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFA 130
             K+A++ F      +          +L  QL+LK +  ++ + +   L+E L++ NK F 
Sbjct: 1446 KKKAQSRFTQHQNTV---------KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD 1496

Query: 131  EVKNQEVTIKA-LKEKIREYEQTLKNQA------------ETIALE------KEQKLQND 171
             +K +    K+ +++K    E  LK+Q             +TI +E      K    Q D
Sbjct: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKD 1556

Query: 172  FAEKE-----RKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE---ETT 223
               KE     +  QE      ++++EAE K+ +L+  +   + EL   K + +       
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616

Query: 224  AKADEIEMIMTDLERANQRAEVAQREAETLRE-QLSSANHSLQLASQIQKAPDVEQAIEV 282
            +K +E++ +   LE     +E A + AE  R+ +   A    QL SQ+++  +  +    
Sbjct: 1617 SKEEELKALEDRLE-----SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTE 1671

Query: 283  LTRSSLEVELAAKEREIAQLVEDVQRLQASL--TKLRENSASQISQLEQQLSA--KNSTL 338
               S L  +L  +ERE+  L E ++ +++S   T +   SA  ++   +Q  A  +    
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731

Query: 339  KQLEEKL 345
            K  EEK+
Sbjct: 1732 KTYEEKI 1738



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 63/309 (20%), Positives = 141/309 (45%), Gaps = 41/309 (13%)

Query: 111 IETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQN 170
           + +E + L+E L+E  +E  ++K+  +   A K K+    +  KN  E +  +K   +  
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHM---AEKTKLITQLRDAKNLIEQLEQDKGMVI-- 366

Query: 171 DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIE 230
             AE +R++ ET       LE  E ++  L++ +++  T+  +L+ + ++   A  +E+E
Sbjct: 367 --AETKRQMHET-------LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELE 417

Query: 231 MIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSS--- 287
             ++  ++  +     + E +   + +   +   +++ Q + +   ++ ++V+ +SS   
Sbjct: 418 KALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQ 477

Query: 288 -------LEVELAAKEREIAQLVEDVQR-LQASLTKLRENSASQISQLEQQLSAKNS-TL 338
                   E ELA KE+E+ + ++  +R  Q  +    E S S+  ++ Q+   + S  L
Sbjct: 478 IAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537

Query: 339 KQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAA 398
           ++LE  L+ +A   E + +L  L             Q  A+     +LE   SL+     
Sbjct: 538 EELE--LQKKAILTESENKLRDL-------------QQEAETYRTRILELESSLEKSLQE 582

Query: 399 LRISNSDLS 407
            +  + DL+
Sbjct: 583 NKNQSKDLA 591



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 68/319 (21%), Positives = 135/319 (42%), Gaps = 47/319 (14%)

Query: 107  RLHDIETENQKLRETLEEYNKEFAEVKN---QEVTIKALKEKIREYEQTLKNQAETIALE 163
            +L   E E QKL + +    K+   ++    QE+ I   KE  +E E+ +K + E + L+
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILK-KEYDQEREEKIKQEQEDLELK 1989

Query: 164  KEQKLQN-------DFAEKERKLQETQMSTTSKLEEAEHKV-----QSLQTALEKTRTEL 211
                L+          A+KE++L+ T   T +K +E E ++     +     L+K   + 
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD 2049

Query: 212  FDLKT---KYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLAS 268
             DLK    +Y+E   A+ +E+   + DL+   Q  E+ ++  + L ++ +  N ++ +  
Sbjct: 2050 DDLKRTAKRYEEILDAREEEMTAKVRDLQ--TQLEELQKKYQQKLEQEENPGNDNVTI-- 2105

Query: 269  QIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLE 328
                   +E   ++  +++L  +   KE+E     E +  L+  L K  +N    +    
Sbjct: 2106 -------MELQTQLAQKTTLISDSKLKEQEFR---EQIHNLEDRLKKYEKN----VYATT 2151

Query: 329  QQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLL-- 386
                 K   L   +  L G+        E   L+ + F    G  T+  AK +  +L   
Sbjct: 2152 VGTPYKGGNLYHTDVSLFGE------PTEFEYLRKVLFEYMMGRETKTMAKVITTVLKFP 2205

Query: 387  --EKNRSLQSENAALRISN 403
              +  + L+ E+A L  ++
Sbjct: 2206 DDQTQKILEREDARLMFTS 2224


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 147/757 (19%), Positives = 307/757 (40%), Gaps = 73/757 (9%)

Query: 9    LKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTP-----EDLRKQVAPLLKSFQGE 63
            L+ ++ A A  LA+ ++  +Q  K  I+   + K+ T      E++  ++    +  + E
Sbjct: 891  LQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950

Query: 64   IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLE 123
               L K   + E     V K      + V   +L +++    + +  +  E + L+E  +
Sbjct: 951  CSELKKDIDDLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQ 1008

Query: 124  EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 183
            +   +    +++  T+   K K+ +    L+      +LE+E+KL  D    +RKL+   
Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEG-----SLEQEKKLCMDLERAKRKLEGDL 1063

Query: 184  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT------AKADEIEMIMTDLE 237
                    + E+  Q L   L+K   E+ +L+ K ++E         K  E++  + +LE
Sbjct: 1064 KLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELE 1123

Query: 238  RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKER 297
               +    ++ +AE  R  LS      +++ ++++A     A ++      E E     R
Sbjct: 1124 EEIEAERASRAKAEKQRSDLS--RELEEISERLEEAGGATSA-QIEMNKKREAEFQKMRR 1180

Query: 298  EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKE 357
            +   L E   + +A+   LR+  A  +++L +Q+     +L+++++KL  + +  E+K E
Sbjct: 1181 D---LEESTLQHEATAAALRKKHADSVAELGEQI----DSLQRVKQKL--EKEKSELKME 1231

Query: 358  LNILKS-MEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKD 416
            +N L S ME      A  +   + LE  L E     + +   +    ++LS    R   +
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI----NELSAQKARLHTE 1287

Query: 417  QPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTG 476
              E  R         SQL R  G+QA     T Q     L +     + A  +L  A   
Sbjct: 1288 SGEFSRQLDEKDAMVSQLSR--GKQAF----TQQIEE--LKRQLEEETKAKSTLAHALQS 1339

Query: 477  KFALNSLLQRQLMQSFYSKA-----MQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD--V 529
                  LL+ Q  +   +KA     M +A S    + T  Y T++I     L+++     
Sbjct: 1340 ARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT-KYETDAIQRTEELEEAKKKLA 1398

Query: 530  NGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI 589
              +  +    E+  S     E     +  +V++ +I  ++ +       L   Q +  ++
Sbjct: 1399 QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMI--DVERSNAACIALDKKQRNFDKV 1456

Query: 590  LARPKPWNKLTVRGKEPFHKMKQFLSD---------EQNILALRSIQGRQRENPGQSLNR 640
            LA  K   + T    E   K  + LS          E+++  L +++ R+ +N  Q ++ 
Sbjct: 1457 LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLK-RENKNLQQEISD 1515

Query: 641  LFQEVPKRRNGSEGNITTRIRAS--------ETGSDEAIKSILEQAKRELQVQKTAEPAQ 692
            L +++ +   G   +   +++          +T  +EA  S+  +  + L++Q      +
Sbjct: 1516 LTEQIAE--GGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573

Query: 693  PSSASGSGNSDDAIRSILQQARREMEAQQAALDPALK 729
                      D+ +  + +   R +E+ Q+ LD  ++
Sbjct: 1574 SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIR 1610



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 72/325 (22%), Positives = 141/325 (43%), Gaps = 21/325 (6%)

Query: 100  QLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAET 159
            +L  K++ L       +++    EE+ K   E+   E   K L+EK+    Q  KN  + 
Sbjct: 835  KLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQE-KNDLQ- 892

Query: 160  IALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYD 219
            + ++ E     D  E+  +L +T++   +K++E   + +      E+   EL   K K +
Sbjct: 893  LQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLE 948

Query: 220  EETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQA 279
            +E +    +I+ +   L +  +     + + + L E+++       L   I K    ++A
Sbjct: 949  DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKA 1002

Query: 280  IEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLS-AKNSTL 338
            ++   + +L+ +L  +E ++  L +   +L+  +  L E S  Q  +L   L  AK    
Sbjct: 1003 LQEAHQQTLD-DLQMEEDKVNTLTKAKTKLEQQVDDL-EGSLEQEKKLCMDLERAKRKLE 1060

Query: 339  KQLEEKLKGQADYEEVKKELN-ILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENA 397
              L+   +   D E  K++LN  LK  EF  S   G  +  + L + L +K + LQ+   
Sbjct: 1061 GDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQA--- 1117

Query: 398  ALRISNSDLSGSARRKGKDQPESRR 422
              RI   +    A R  + + E +R
Sbjct: 1118 --RIEELEEEIEAERASRAKAEKQR 1140



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 91/432 (21%), Positives = 166/432 (38%), Gaps = 86/432 (19%)

Query: 10   KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE--DLRKQVAP----------LL 57
            ++E  + +T L   ++  E+S   L    RE K    E  DL +Q+A           + 
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVK 1534

Query: 58   KSFQGEIDALSKRSKEAEAAF-------------LNVYKRLID--VPDPVPALDLGQQLQ 102
            K    E   L    +EAEA+              LN  K  ID  + +    LD     Q
Sbjct: 1535 KQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD-----Q 1589

Query: 103  LKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKI----REYEQTLKNQAE 158
            LK   L  +E+    L   +   N      K  E  +  ++ ++    R+  + L+N   
Sbjct: 1590 LKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRN 1649

Query: 159  TIALEKEQKLQNDFA---EKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTR------- 208
            T  + K+ +L  D A   + + K Q   +   + L +AE  V+ L+ +LE+T        
Sbjct: 1650 TQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAE--VEELRASLERTERGRKMAE 1707

Query: 209  -----------------TELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREA- 250
                             T L + K K + + +    E+E I+ +   A ++A+ A  +A 
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAA 1767

Query: 251  ----ETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE------VELAAKEREIA 300
                E  +EQ +SA+      +  Q   D++  ++   + +L+       +L A+ RE+ 
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELE 1827

Query: 301  QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKL----------KGQAD 350
              VE  Q+      K       ++ +L  Q       + +L++ +          K QA+
Sbjct: 1828 SEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAE 1887

Query: 351  YEEVKKELNILK 362
              E +  +N+ K
Sbjct: 1888 EAEEQSNVNLAK 1899



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 40/208 (19%), Positives = 96/208 (46%), Gaps = 16/208 (7%)

Query: 50   RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 109
            +K++   +   QGE++ + + ++ AE       K + D      A  + ++L+ +     
Sbjct: 1731 KKKLETDISQIQGEMEDIVQEARNAEE---KAKKAITD------AAMMAEELKKEQDTSA 1781

Query: 110  DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ 169
             +E   + + +T+++      E   +++ +K  K++I++ E  ++     +  E EQK  
Sbjct: 1782 HLERMKKNMEQTVKDLQLRLDEA--EQLALKGGKKQIQKLEARVRELESEV--ESEQKHN 1837

Query: 170  NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE---ETTAKA 226
             +  +  RK +      T + EE    +  LQ  ++K +T++   K + +E   ++    
Sbjct: 1838 VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897

Query: 227  DEIEMIMTDLERANQRAEVAQREAETLR 254
             +   +  +LE A +RA++A+ +   LR
Sbjct: 1898 AKFRKLQHELEEAKERADIAESQVNKLR 1925


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 108/514 (21%), Positives = 218/514 (42%), Gaps = 64/514 (12%)

Query: 2    LCVAGARLKRELDATATVLANRQDESEQSRK---RLIEQSREFKKNTPEDLRKQV--APL 56
            L    ++L+ ELD  +T+L   + +  +  K    L  Q ++ ++   E+ R+++  +  
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337

Query: 57   LKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPAL------DLGQQLQL---KVQR 107
            ++  + E ++L ++ +E E A  N+ K+++ +   +         DLG    L   K + 
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397

Query: 108  LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIA-LEKEQ 166
            L D E  +Q+L E    Y+K        E T   L++++ +    L +Q +  + LEK+Q
Sbjct: 1398 LKDAEALSQRLEEKALAYDK-------LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQ 1450

Query: 167  KLQNDFAEKERKLQ----ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEET 222
            K  +    +E+ +     E +    ++  E E K  SL  ALE    E  + K +++ + 
Sbjct: 1451 KKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE----EALEAKEEFERQN 1506

Query: 223  TAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSL-QLASQIQKAPDVEQAIE 281
                 ++E +M+  +   +     ++    L +Q+      L +L  ++Q   D +  +E
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566

Query: 282  V---LTRSSLEVELAAKEREIAQ----LVEDVQRLQASLTKLRENSASQI---------- 324
            V     ++  E +L  ++ +  +    L++ V+ L+A L   R+  A  +          
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626

Query: 325  ----SQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKP 380
                +Q+E    A++  +KQL +      DY+   +E    +   FA S+   ++   K 
Sbjct: 1627 KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK--ESEKKLKS 1684

Query: 381  LEVLLLEKNRSLQSENAALRISN-------SDLSGSARRKGKDQPESRRPGSLPAPPPSQ 433
            LE  +L+    L S   A R +         +++ SA  K     E RR  +  A    +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744

Query: 434  LPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLAS 467
            L     EQ++      +F    L  D  ++ LA+
Sbjct: 1745 LEE---EQSNMELLNDRFRKTTLQVDTLNAELAA 1775



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 79/317 (24%), Positives = 148/317 (46%), Gaps = 42/317 (13%)

Query: 120  ETLEEYNKEFAEVKNQEVTIKA-LKEKIREYEQTLKN--------QAETIALEKEQKLQN 170
            E L+  ++E  +VK ++  ++  L+E  R+++Q L+         QAET    + ++++ 
Sbjct: 852  EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRA 911

Query: 171  DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIE 230
              A K+++L+E      S++EE E + Q LQ   +K +  + DL+ + DEE  A+     
Sbjct: 912  RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ---- 967

Query: 231  MIMTDLERANQRAEVAQREAE--TLREQLSS------------ANHSLQLASQIQKAPD- 275
                 LE+    A++ + E E   L +Q S             A  S QLA + +KA + 
Sbjct: 968  --KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025

Query: 276  --VEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSA 333
              +    EV+  S LE  L  +E+   +L +  ++L    T L++    QI++L+ Q+  
Sbjct: 1026 AKIRNKQEVMI-SDLEERLKKEEKTRQELEKAKRKLDGETTDLQD----QIAELQAQIDE 1080

Query: 334  KNSTLKQLEEKLKG---QADYEEVKKE--LNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388
                L + EE+L+G   + D E + K   L +++ ++   +E     ++ K       ++
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140

Query: 389  NRSLQSENAALRISNSD 405
             R L  E  AL+    D
Sbjct: 1141 KRDLSEELEALKTELED 1157



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 96/426 (22%), Positives = 167/426 (39%), Gaps = 21/426 (4%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            ++ REL A    L    +  + SR +  +Q R+  +   E L+ ++   L +   + +  
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL-EALKTELEDTLDTTAAQQELR 1169

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127
            +KR  E E A L                D+ Q+    ++ L +   + ++ +  LE+ NK
Sbjct: 1170 TKR--EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK-NK 1226

Query: 128  EFAEVKNQEVT--IKALKEKIREYEQTLKN-----QAETIALEKEQKLQNDFAEKERKLQ 180
            +  E  N+E+   +K L++   E E   K      Q     + +  +L+ + AEK  KLQ
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286

Query: 181  ETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
                + ++ LEEAE K            ++L D +    EET  K + +   +  LE   
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEK 1345

Query: 241  QRAEVAQREAETLREQLSSANHSL--QLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE 298
               +  Q E E  R+ L     +L  QLA   +K  D    IE L  +  + +L      
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA--KKKLLKDAEA 1403

Query: 299  IAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
            ++Q +E+       L K +     ++  L   L  +      LE+K K        +K +
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 359  NILKSMEFAPSEGAGTQDAAKPLEVL-----LLEKNRSLQSENAALRISNSDLSGSARRK 413
            +   + E   +E    +   K L +       LE     + +N  LR    DL  S    
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523

Query: 414  GKDQPE 419
            GK+  E
Sbjct: 1524 GKNVHE 1529



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 93/412 (22%), Positives = 171/412 (41%), Gaps = 31/412 (7%)

Query: 10   KRELDATATVLANRQDESEQSRKRL----IEQSREFKKNTPE-----DLRKQVAPLLKSF 60
            K+++ A    L  + DE E +R++L    +    + KK   E     D   +     K  
Sbjct: 945  KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004

Query: 61   QGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRE 120
            +  I   S +  E E    N+ K  I     V   DL ++L+ + +   ++E   +KL  
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAK--IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062

Query: 121  TLEEYNKEFAEVKNQEVTIKA-LKEKIREYEQTL-KNQAETIALEKEQKLQNDFAEKERK 178
               +   + AE++ Q   +K  L +K  E +  L +   ET+      K+  +   +  +
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122

Query: 179  LQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFD----------LKTKYDEETT----A 224
            LQE   S  +   +AE + + L   LE  +TEL D          L+TK ++E      A
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182

Query: 225  KADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLT 284
              +E +     ++   QR   A  E     EQ      +L+   Q  +  + E A EV  
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242

Query: 285  RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344
               ++ E   K +++   V+++    +   +LR   A + S+L+ +L   ++ L++ E+K
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302

Query: 345  -LKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 395
             +K   D   ++ +L    + E    E     + +  +  L  EKN SLQ +
Sbjct: 1303 GIKFAKDAASLESQLQ--DTQELLQEETRQKLNLSSRIRQLEEEKN-SLQEQ 1351



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 144/625 (23%), Positives = 238/625 (38%), Gaps = 80/625 (12%)

Query: 139  IKALKEKIREYEQTLKNQAETIAL-EKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197
            +K L +  R+ E+      E + + EK+ K++ +  E ERK Q+        LEE     
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQL-------LEEKNILA 893

Query: 198  QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257
            + LQ       TELF    +      AK  E+E I+ DLE        ++ E E  R Q+
Sbjct: 894  EQLQ-----AETELFAEAEEMRARLAAKKQELEEILHDLE--------SRVEEEEERNQI 940

Query: 258  SSANHSLQLASQIQKAPDVEQAI--EVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
               N   ++ + IQ   D+E+ +  E   R  L++E    E +I ++ E++  L+   +K
Sbjct: 941  LQ-NEKKKMQAHIQ---DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996

Query: 316  LRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQ 375
                   +   +E +++  +S L + EEK K  A     K+E+ I    E    E    Q
Sbjct: 997  F----IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN-KQEVMISDLEERLKKEEKTRQ 1051

Query: 376  DAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLP 435
            +  K    L  E    LQ + A L+    +L     +K     E    G+L       L 
Sbjct: 1052 ELEKAKRKLDGE-TTDLQDQIAELQAQIDELKLQLAKK-----EEELQGALARGDDETLH 1105

Query: 436  RNPGEQASNTNGTHQFSPAGLSQDF----FSSSLASPSLPLASTGKFALNSLLQRQL--- 488
            +N    A       Q   A L +DF     S + A       S    AL + L+  L   
Sbjct: 1106 KN---NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162

Query: 489  --MQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSV- 545
               Q   +K  QE              T +  +Q    +      +     Q E A    
Sbjct: 1163 AAQQELRTKREQEVAELKKALEE---ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219

Query: 546  ------SEGEEMDTAEIARQVKE-QLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNK 598
                   +G E D  E+A +VK  Q +K          +        V E+ A+    ++
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAE------SEHKRKKLDAQVQELHAKVSEGDR 1273

Query: 599  LTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLF---QEVPKRRNGSEGN 655
            L V   E   K++  L +   +L     +G +      SL       QE+ +     + N
Sbjct: 1274 LRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN 1333

Query: 656  ITTRIRASETGSDEAIKSILEQAKRELQVQKTAE----PAQPSSASGSGNSDDAIRSI-- 709
            +++RIR  E    E   S+ EQ + E + +K  E      Q   A      DD + +I  
Sbjct: 1334 LSSRIRQLE----EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389

Query: 710  LQQARREMEAQQAALDPALKQAPLS 734
            L++A++++     AL   L++  L+
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALA 1414



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 69/325 (21%), Positives = 139/325 (42%), Gaps = 48/325 (14%)

Query: 11   RELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKR 70
            R+L A         +E+  SR  +  QS+E +K             LKS + EI  L + 
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKK------------LKSLEAEILQLQEE 1695

Query: 71   SKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFA 130
               +E A  +  +   ++ D +     G+   L  +R   +E    +L E LEE      
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRR--LEARIAQLEEELEE------ 1747

Query: 131  EVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKL 190
            E  N E+    L ++ R+    +      +A E+    ++D A ++ + Q  ++   +KL
Sbjct: 1748 EQSNMEL----LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK--AKL 1801

Query: 191  EEAEHKVQS-LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQ---RAEVA 246
            +E E  V+S  +  +     ++  L+ + ++E   +A   +++    ++  +   + E  
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDE 1861

Query: 247  QREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDV 306
            +R A+  +EQ+  AN     A   Q    +E+A E  TR++      A  R++ + ++D 
Sbjct: 1862 RRHADQYKEQMEKAN-----ARMKQLKRQLEEAEEEATRAN------ASRRKLQRELDDA 1910

Query: 307  QRLQASLTKLRENSASQISQLEQQL 331
                   T+  E  + ++S L+ +L
Sbjct: 1911 -------TEANEGLSREVSTLKNRL 1928


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 92/449 (20%), Positives = 194/449 (43%), Gaps = 69/449 (15%)

Query: 25   DESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKR 84
            ++ EQ + +L+E+ R  K++  E+L K +  + K    +     K+ KE +   L   ++
Sbjct: 1264 NDLEQQKNKLMEELRR-KRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRK 1322

Query: 85   LIDVP-----DPVPALDLGQQLQLKV-----------------QRLHDIETENQK----L 118
            + ++      + +P   + Q    +                  Q++ ++   N+K    +
Sbjct: 1323 ITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382

Query: 119  RETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERK 178
            RE   E N    E  + E   + LK+K+ E   TL+     + LE++ + +  ++++ R+
Sbjct: 1383 RELTYELNALQLEKTSSEEKARLLKDKLDETNNTLR--CLKLELERKDQAEKGYSQQLRE 1440

Query: 179  LQETQMSTTSKLEEAEHKVQSL-------QTALEKTRTELFDLKTKYDEETTAKA---DE 228
            L      TT K EEA  +   L       Q  LE    E   L+ + D  T A A     
Sbjct: 1441 LGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKN 1500

Query: 229  IEMIMTDL-----ERANQRAEVAQREAETLREQLSSANHSL--QLASQIQKAPDVEQAIE 281
            I+ + + +     E+  +R ++ QR+++ L+EQ   ++  L   + ++ +    +++  E
Sbjct: 1501 IQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNE 1560

Query: 282  VLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQL 341
             L +S+   E+      + Q VE++ R Q + TKL      +I    + +  +  T++Q 
Sbjct: 1561 ELEKSNECAEM------LKQKVEELTR-QNNETKL---MMQRIQAESENIVLEKQTIQQR 1610

Query: 342  EEKLKGQAD-------------YEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEK 388
             E LK QAD             +++ K E +  + ++    + A +Q+     +    ++
Sbjct: 1611 CEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQ 1670

Query: 389  NRSLQSENAALRISNSDLSGSARRKGKDQ 417
            N  +Q+    +R  N++L+ S   K + +
Sbjct: 1671 NIIIQNTKKEVRNLNAELNASKEEKRRGE 1699



 Score = 60.8 bits (146), Expect = 9e-09
 Identities = 73/347 (21%), Positives = 136/347 (39%), Gaps = 44/347 (12%)

Query: 28   EQSRKRLIEQSREFKKNTPEDLRKQ--VAPLLKSFQGEIDALSKRSKEAEAAFLN----- 80
            E +++++ E   E  K     L +Q  +   ++  Q ++D   K +++  A   +     
Sbjct: 984  ETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQT 1043

Query: 81   -VYKRLIDVPD--PVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEV 137
              Y+ ++D     PV    +     L +Q   D+ T    L   + +Y K   +      
Sbjct: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD------ 1097

Query: 138  TIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKV 197
            ++K L+E      + +K   ET     E    +D  ++++         T K+ E E  V
Sbjct: 1098 SLKRLEE------EEIKRCKET----SEHGAYSDLLQRQKATVLENSKLTGKISELERMV 1147

Query: 198  QSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQL 257
              L+    +   EL  ++   + E   +   +E I     RA   A+  +RE ET+  + 
Sbjct: 1148 AELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREK 1207

Query: 258  SSANHSLQLASQIQKAPDVEQAI--------------EVLTRSSLEVELAAKEREIAQLV 303
             +A   L+   Q+    + ++A                  TR +LE  L  K+  +  L 
Sbjct: 1208 EAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLE 1267

Query: 304  EDVQRLQASLTKLRENS---ASQISQLEQQLS-AKNSTLKQLEEKLK 346
            +   +L   L + R+N       I Q+E+ L+  K    KQL+EK K
Sbjct: 1268 QQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQK 1314



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 58/268 (21%), Positives = 119/268 (44%), Gaps = 36/268 (13%)

Query: 104  KVQRLHD-IETENQ---KLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAET 159
            K+QRL++ +E  N+    L++ +EE  ++  E K     I+A  E I   +QT++ + E 
Sbjct: 1554 KIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEA 1613

Query: 160  IALE----------------KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTA 203
            + ++                K+ K + DF  K + L+E    + + + E + K       
Sbjct: 1614 LKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNII 1673

Query: 204  LEKTRTELFDLKTKYD---EETTAKADEIEMIMTDLERANQRAEVAQRE--AETLREQLS 258
            ++ T+ E+ +L  + +   EE      ++++    ++  N R +  Q E   +T+ EQ++
Sbjct: 1674 IQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMT 1733

Query: 259  SANHSL---QLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTK 315
                 L   +     Q A +  + +E L  S +       E +I+ +  D   LQ   ++
Sbjct: 1734 HRKMVLFQEESGKFKQSAEEFRKKMEKLMESKV-----ITENDISGIRLDFVSLQQENSR 1788

Query: 316  LRENS---ASQISQLEQQLSAKNSTLKQ 340
             +EN+    + I +LE+QL      ++Q
Sbjct: 1789 AQENAKLCETNIKELERQLQQYREQMQQ 1816



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 76/365 (20%), Positives = 161/365 (44%), Gaps = 48/365 (13%)

Query: 10   KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPE-DLRKQVAP-LLKSFQGEIDAL 67
            + E+D    V    +DE ++++    E  + +K+   + D  K+ A  L++ +Q     +
Sbjct: 893  RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 952

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127
              R ++ E     + K L    D    LD           +  +ET  +K++E   E +K
Sbjct: 953  DNRLRDLEG----IGKSLKYYRDTYHPLD---------DWIQQVETTQRKIQENQPENSK 999

Query: 128  EFA-EVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMST 186
              A ++  Q++ +  ++ K  + ++  K   +  A  K+ +LQ            T  + 
Sbjct: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQT----------MTYRAM 1049

Query: 187  TSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVA 246
                +++  K + +Q++ +    E  DL+T+Y    T     I+     L+R        
Sbjct: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL------- 1102

Query: 247  QREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDV 306
              E E  R + +S + +     Q QKA        VL  S L  +++  ER +A+L +  
Sbjct: 1103 -EEEEIKRCKETSEHGAYSDLLQRQKA-------TVLENSKLTGKISELERMVAELKKQK 1154

Query: 307  QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL-NILKSME 365
             R++  L K+RE + +++   +QQ + ++ +L    +K++ +++ ++ ++EL  I++  E
Sbjct: 1155 SRVEEELPKVREAAENELR--KQQRNVEDISL----QKIRAESEAKQYRRELETIVREKE 1208

Query: 366  FAPSE 370
             A  E
Sbjct: 1209 AAERE 1213



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 30/127 (23%), Positives = 61/127 (48%), Gaps = 3/127 (2%)

Query: 101  LQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKN--QAE 158
            ++ KV   +DI           +E ++     K  E  IK L+ ++++Y + ++     E
Sbjct: 1762 MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHME 1821

Query: 159  TIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKY 218
                +K QKL+++   ++R+++  +     +++E EH++  LQ  ++K  T   D   K 
Sbjct: 1822 ANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAK-DCTFKP 1880

Query: 219  DEETTAK 225
            D E T K
Sbjct: 1881 DFEMTVK 1887



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 53/313 (16%), Positives = 118/313 (37%), Gaps = 20/313 (6%)

Query: 96   DLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKN 155
            +L  +L+     LH    E Q     +  + +E  + K      +   EK+ E +   +N
Sbjct: 1711 ELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITEN 1770

Query: 156  QAETIALE-KEQKLQNDFAEKERKLQETQMSTTSK--------LEEAEH-------KVQS 199
                I L+    + +N  A++  KL ET +    +        +++ +H       K Q 
Sbjct: 1771 DISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830

Query: 200  LQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSS 259
            L+  L   + E+ +LK K D++      ++ ++  ++++ +   +   +        +  
Sbjct: 1831 LEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFK--PDFEMTVKE 1888

Query: 260  ANHSLQLASQI--QKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLR 317
              HS +L+S+      P     +   T+    +E   + R + Q+ ++VQ         +
Sbjct: 1889 CQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEK 1948

Query: 318  ENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDA 377
            E S    S+   Q S +          +   ++ E+++ +            + A   + 
Sbjct: 1949 EKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPVRYQDNACEMEL 2008

Query: 378  AKPLEVLLLEKNR 390
             K L  L + KN+
Sbjct: 2009 VKVLTPLEIAKNK 2021


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 74.3 bits (181), Expect = 8e-13
 Identities = 92/397 (23%), Positives = 174/397 (43%), Gaps = 46/397 (11%)

Query: 24  QDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYK 83
           Q + E +R + +EQS  F+K   + L++++     +   E   + +  K+       V +
Sbjct: 458 QTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517

Query: 84  RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQ-------- 135
               +    PA D+   L L    L +I +  +KL  T  ++ +E   +K          
Sbjct: 518 LRRRLESNKPAGDVDMSLSL----LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573

Query: 136 EVTIKAL---KEKIREYEQTLKNQAE--------TIALEKEQKLQNDFAEKERKLQETQM 184
           +  IKAL    EK+ +  ++LK++ E         IAL K  KL+   A  ++ ++E ++
Sbjct: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS-KLETAIASHQQAMEELKV 632

Query: 185 STTSKLEEAEHKVQSLQTALEKTRT----ELFDLKTKYDEETTAKADEIEMIMTDLERAN 240
           S +  L     +   L+T +EK R     E+ +L+ + D E  A A E+E +   L +  
Sbjct: 633 SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVI 692

Query: 241 QRAEVAQREAETLREQLSSA--NHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKERE 298
           +  E      E +R +L  A   H +++   + K  + E  ++      LEV L AK  E
Sbjct: 693 KEKE---NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK-----ELEV-LQAKCNE 743

Query: 299 IAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
             +++++      S  K  E     +  L +  S   S +K+L ++L+     E+  K L
Sbjct: 744 QTKVIDNF----TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHL 796

Query: 359 NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSE 395
            I K+ E + +     +   + L++  L++N S  S+
Sbjct: 797 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 79/397 (19%), Positives = 168/397 (42%), Gaps = 68/397 (17%)

Query: 8    RLKRELDATATVLANRQDE--SEQSRKRLIE---QSREFKKNTPEDLRKQVAPLLKSFQG 62
            +L+++L+A    + + + E  +E S+   I    Q RE K    ++   +V+ + ++ + 
Sbjct: 781  KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840

Query: 63   EIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL 122
            E+  L ++  EA    ++V + + +  +         +L  K ++ + + ++ +KLRE L
Sbjct: 841  ELQILKEKFAEASEEAVSVQRSMQETVN---------KLHQKEEQFNMLSSDLEKLRENL 891

Query: 123  EEYNKEFAEVKNQEVTIKALKEKIR-EYEQTLKNQAETIALEKEQKLQNDFAEKERKLQE 181
             +   +F E   +E  +   KEK+  +  + +K   +  +  +  K+ ++   KER ++E
Sbjct: 892  ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS--QLTKMNDELRLKERDVEE 949

Query: 182  TQMSTTSKLEEA--------------------------------EHKVQSLQTALEKTRT 209
             Q+  T   E A                                E K+  L+  +E +  
Sbjct: 950  LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN 1009

Query: 210  ELFDLKTKYDEETTAKADEIEMIMTDLER----ANQRAEVAQREAETLREQLSSANHSLQ 265
            +  +LK +Y+  T+    + E I+ +L++       + + A+ E   L ++L        
Sbjct: 1010 QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD 1069

Query: 266  LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQIS 325
             A   Q A D  Q +E +T+   E   + ++ +     +   +LQ  L  L+EN+   + 
Sbjct: 1070 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK-----QTNAKLQNELDTLKENNLKNVE 1124

Query: 326  QLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILK 362
            +L      K+  L  +E +       EE +KE+  LK
Sbjct: 1125 ELN-----KSKELLTVENQ-----KMEEFRKEIETLK 1151



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 81/349 (23%), Positives = 152/349 (43%), Gaps = 74/349 (21%)

Query: 47  EDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQ 106
           E LR ++  ++K  +  ++A+  +  +AE       + L+++ D +  L   Q+ ++KV+
Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAED------QHLVEMEDTLNKL---QEAEIKVK 732

Query: 107 RLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQ 166
            L  ++ +  +  + ++ +  +          +KA +EK+ + +   K  +E  +  K+ 
Sbjct: 733 ELEVLQAKCNEQTKVIDNFTSQ----------LKATEEKLLDLDALRKASSEGKSEMKKL 782

Query: 167 KLQNDFAEKERKLQETQ--------MSTTSKLEEAEHKVQSLQTAL-------EKTRTEL 211
           + Q + AEK+ K  E +         S T +L+  E K+ +LQ  L       E    EL
Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842

Query: 212 FDLKTKYDEETT-----------------AKADEIEMIMTDLERANQR---AEVAQREAE 251
             LK K+ E +                   K ++  M+ +DLE+  +     E   RE +
Sbjct: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 902

Query: 252 TLREQLSSANHSLQ--LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRL 309
              EQL  A   L+  +A  ++ + D    +     + +  EL  KER       DV+ L
Sbjct: 903 EREEQLIKAKEKLENDIAEIMKMSGDNSSQL-----TKMNDELRLKER-------DVEEL 950

Query: 310 QASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
           Q  LTK  EN++        Q S ++ T+K  + + +    +EE KKEL
Sbjct: 951 QLKLTKANENASF------LQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 993



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 83/381 (21%), Positives = 162/381 (42%), Gaps = 47/381 (12%)

Query: 1   MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSF 60
           +L    +R  R++  T T L     E +Q  ++L+ +          DL +       S 
Sbjct: 335 LLTETSSRYARKISGT-TALQEALKEKQQHIEQLLAE---------RDLERAEVAKATSH 384

Query: 61  QGEIDALSKRSKEA-EAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLR 119
            GEI+     +++  +   L +  ++  +   V A D     + KV+ L+ +E E +K+ 
Sbjct: 385 VGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD-----REKVELLNQLEEEKRKVE 439

Query: 120 ETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTL---KNQAETIALEKEQKLQNDFAEKE 176
           +      +E     + E   K    +I+E EQ+L   K +A+ +  E E       +EK 
Sbjct: 440 DLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKS 499

Query: 177 RKLQETQMSTTSKLEEAEHKVQSLQTALEKTR-TELFDLKTKYDEETTAKADEIEMIMTD 235
           R + E +     +++E    V  L+  LE  +     D+     +E ++  +++E+  TD
Sbjct: 500 R-IMELEKDLALRVQE----VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTD 554

Query: 236 LERA--------NQRAEVAQREAE---TLREQLSSANHSLQLASQIQKAPDVEQAIEVLT 284
            +R           R E  Q+E +   T  E+LS  N SL+  S+++ A      +  L 
Sbjct: 555 HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK--SKLEHANKENSDVIALW 612

Query: 285 RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344
           +S LE  +A+ +       + ++ L+ S +K      ++ ++L+ Q+       +   E 
Sbjct: 613 KSKLETAIASHQ-------QAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIEN 665

Query: 345 LKGQADYEEV--KKELNILKS 363
           L+ Q D E     KE+  L++
Sbjct: 666 LQNQQDSERAAHAKEMEALRA 686



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 77/332 (23%), Positives = 146/332 (43%), Gaps = 47/332 (14%)

Query: 99   QQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIR-----EYEQTL 153
            +Q Q +  + H  E E ++L   L +  K+     NQ   +KA  E+       ++E+ L
Sbjct: 976  EQSQQEAAKKH--EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 1033

Query: 154  KNQAETIALEKEQKLQNDFAEKERKLQET-----QMSTTSKLEEAEHKVQSLQ------- 201
            +N  +T+ L+ E KL+    E    LQE      Q       + AE  +Q ++       
Sbjct: 1034 QNLQKTL-LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1092

Query: 202  ---TALEKTRTELFDLKTKYD---EETTAKADEIEMIMTDLERANQRAEVAQREAETLR- 254
                +LE T+     L+ + D   E      +E+      L   NQ+ E  ++E ETL+ 
Sbjct: 1093 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1152

Query: 255  ------EQLSS-ANHSLQLASQIQKAPDVEQAIEVL--TRSSLEVELAAKEREIAQLVED 305
                  +QLS+    +++LA ++ ++ D   + + L   RS L  +L   ++  ++ ++D
Sbjct: 1153 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKD 1212

Query: 306  VQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKG-QADYEEVKKELNILKSM 364
                +ASL K        IS     L+ K++ L++L  ++   + +    K   ++++++
Sbjct: 1213 ADEEKASLQK-------SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTL 1265

Query: 365  EFAPSEGAGTQDAAKPLEVLLLEKNRSLQSEN 396
            E   S+    +   K LE+ L E  R L S +
Sbjct: 1266 E---SDKVKLELKVKNLELQLKENKRQLSSSS 1294



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 58/253 (22%), Positives = 108/253 (42%), Gaps = 49/253 (19%)

Query: 7    ARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA 66
            A+L+ ELD          +E  +S++ L  ++++      E+ RK++  L ++   +   
Sbjct: 1106 AKLQNELDTLKENNLKNVEELNKSKELLTVENQKM-----EEFRKEIETLKQAAAQKSQQ 1160

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYN 126
            LS   +E      NV                  +L  ++ R  D  T +QKL E     N
Sbjct: 1161 LSALQEE------NV------------------KLAEELGRSRDEVTSHQKLEEERSVLN 1196

Query: 127  KEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKE-----QKLQNDFA------EK 175
             +  E+K +E   K +K+   E     K+ + T AL  E     +KL+N+          
Sbjct: 1197 NQLLEMKKRE--SKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1254

Query: 176  ERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELF----DLKTKYDEETTAKADEIEM 231
             + L     +  S   + E KV++L+  L++ + +L     +  T+ DE+  A+  +I+ 
Sbjct: 1255 AKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDF 1314

Query: 232  ---IMTDLERANQ 241
               ++ DL+R NQ
Sbjct: 1315 LNSVIVDLQRKNQ 1327


>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
          Length = 284

 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 74/291 (25%), Positives = 139/291 (47%), Gaps = 26/291 (8%)

Query: 64  IDALSKRSKEAEAAFLNVYKRLIDVP-DPVPALDLGQQLQLKV----QRLHDIETENQKL 118
           +DA+ K+ +  +    N   R      D   A D  +QL+ ++    ++L   E E  K 
Sbjct: 1   MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY 60

Query: 119 RETLEEYNK--EFAEVK--NQEVTIKALKEKIREYEQTLKNQAETIA--LEKEQKLQNDF 172
            E L++  +  E AE K  + E  + +L  +I+  E+ L    E +A  L+K ++ +   
Sbjct: 61  SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120

Query: 173 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 232
            E ER ++  +    S+ ++ E K++  +  L++ +    D   KY+E     A ++ +I
Sbjct: 121 DESERGMKVIE----SRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEV----ARKLVII 172

Query: 233 MTDLERANQRAEVAQREAETLREQLSSANHSL-----QLASQIQKAPDVEQAIEVLTRSS 287
            +DLERA +RAE+++ +   L E+L +  ++L     Q     QK    E+ I+VL+   
Sbjct: 173 ESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKL 232

Query: 288 LEVELAAK--EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNS 336
            E E  A+  ER + +L + +  L+  +   +E + S    L+Q L   N+
Sbjct: 233 KEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNN 283



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 51/227 (22%), Positives = 107/227 (47%), Gaps = 21/227 (9%)

Query: 153 LKNQAETIALEKEQKLQN-DFAEKERKLQETQMSTTS-KLEEAEHKVQSLQTALEKTRTE 210
           +K + + + L+KE  L   + AE ++K  E +      +L   + K++  +  L+K    
Sbjct: 4   IKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEA 63

Query: 211 LFDLKTKYD----EETTAKAD------EIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
           L D + K +    + T A+AD       I+++  +L+RA +R   A ++ E   +    +
Sbjct: 64  LKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADES 123

Query: 261 NHSLQ-LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 319
              ++ + S+ QK  +  +  E+  + +  +   A +R+  ++   +  +++ L +  E 
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDA-DRKYEEVARKLVIIESDLERAEER 182

Query: 320 ---SASQISQLEQQLSAKNSTLKQLE---EKLKGQAD-YEEVKKELN 359
              S  + ++LE++L    + LK LE   EK   + D YEE  K L+
Sbjct: 183 AELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLS 229


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 148/756 (19%), Positives = 310/756 (41%), Gaps = 71/756 (9%)

Query: 9    LKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTP-----EDLRKQVAPLLKSFQGE 63
            L+ ++ A +  L + ++  +Q  K   +   + K+ T      E++  ++    +  + E
Sbjct: 888  LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947

Query: 64   IDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLE 123
               L K   + E     V K      + V   +L ++L    + +  +  E + L+E  +
Sbjct: 948  CSELKKDIDDLELTLAKVEKEKHATENKVK--NLTEELSGLDETIAKLTREKKALQEAHQ 1005

Query: 124  EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 183
            +   +    +++  ++   K K+ +  + L++     +LE+E+KL+ D    +RKL+   
Sbjct: 1006 QALDDLQAEEDKVNSLNKTKSKLEQQVEDLES-----SLEQEKKLRVDLERNKRKLEGDL 1060

Query: 184  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETT------AKADEIEMIMTDLE 237
                  + + E+  Q L   L+K   E   L++K ++E T       K  E++  + +LE
Sbjct: 1061 KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE 1120

Query: 238  RANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAK-E 296
               + AE A R A+T +++   A    +L+ ++++A  V         +S ++EL  K E
Sbjct: 1121 EEIE-AERATR-AKTEKQRSDYARELEELSERLEEAGGV---------TSTQIELNKKRE 1169

Query: 297  REIAQLVEDVQRL----QASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYE 352
             E  +L  D++      +A +  LR+  A  +++L +Q+      L+++++KL  + +  
Sbjct: 1170 AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI----DNLQRVKQKL--EKEKS 1223

Query: 353  EVKKELNIL-KSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSAR 411
            E K E++ L  SME      A  +   + LE  L E     + +N  ++ S S+L+    
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE----ARGKNEEIQRSLSELTTQKS 1279

Query: 412  RKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLP 471
            R   +  E  R         SQL R+   + + T  T +       ++   ++LA     
Sbjct: 1280 RLQTEAGELSRQLEEKESIVSQLSRS---KQAFTQQTEELKRQLEEENKAKNALAHALQS 1336

Query: 472  LASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPD--V 529
                         + Q  ++   +A+ +A S    + T  Y T++I     L+++     
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT-KYETDAIQRTEELEEAKKKLA 1395

Query: 530  NGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI 589
              +  S  Q E+  +     E     +  +V++ ++       +     L   Q +  ++
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA--ALDKKQRNFDKV 1453

Query: 590  LARPKPWNKLTVRGKEPFHKMKQFLSDEQNIL------ALRSIQGRQRENPG--QSLNRL 641
            LA  K   + +    E   K  + LS E   L      AL  ++  +REN    Q +  L
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL 1513

Query: 642  FQEVPKRRNG--------SEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQP 693
             +++ +  NG        S   I       +   +EA  ++  +  + L++Q      + 
Sbjct: 1514 TEQIAE--NGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS 1571

Query: 694  SSASGSGNSDDAIRSILQQARREMEAQQAALDPALK 729
                     D+ I  + +  +R +E  Q+ALD  ++
Sbjct: 1572 EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR 1607



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 69/312 (22%), Positives = 132/312 (42%), Gaps = 18/312 (5%)

Query: 108  LHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQK 167
            L   ETE + +    EE+ K   E+   E   K L+EK+     TL  +   + L+ + +
Sbjct: 841  LKSAETEKE-MATMKEEFQKTKDELAKSEAKRKELEEKL----VTLVQEKNDLQLQVQAE 895

Query: 168  LQN--DFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAK 225
             +N  D  E+  +L + +    +K++E   + +      E+   EL   K K ++E +  
Sbjct: 896  SENLLDAEERCDQLIKAKFQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSEL 951

Query: 226  ADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV--EQAIEVL 283
              +I+ +   L +  +     + + + L E+LS  + ++   ++ +KA     +QA++ L
Sbjct: 952  KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL 1011

Query: 284  TRSSLEVELAAKER-EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE 342
                 +V    K + ++ Q VED++       KLR +      +LE  L     ++  LE
Sbjct: 1012 QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLE 1071

Query: 343  EKLKGQADYEEVKKEL---NILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 399
               K Q D    KK+     +   +E   + G   Q   K L+  + E    +++E A  
Sbjct: 1072 ND-KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATR 1130

Query: 400  RISNSDLSGSAR 411
              +    S  AR
Sbjct: 1131 AKTEKQRSDYAR 1142



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 50/209 (23%), Positives = 90/209 (43%), Gaps = 18/209 (8%)

Query: 50   RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH 109
            +K++   L   Q E++  S+ ++ AE       K + D       L   Q     ++R+ 
Sbjct: 1728 KKKLETDLMQLQSEVEDASRDARNAEE---KAKKAITDAAMMAEELKKEQDTSAHLERMK 1784

Query: 110  -DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKL 168
             ++E   + L+  L+E   E   +K  +  I+ L+ +IRE E           LE EQK 
Sbjct: 1785 KNLEQTVKDLQHRLDE--AEQLALKGGKKQIQKLETRIRELE---------FELEGEQKK 1833

Query: 169  QNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKY---DEETTAK 225
              +  +  RK +      T + EE    V  LQ  ++K + ++   K +    DE+  A 
Sbjct: 1834 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1893

Query: 226  ADEIEMIMTDLERANQRAEVAQREAETLR 254
              +      +LE A +RA++A+ +   LR
Sbjct: 1894 LTKFRKAQHELEEAEERADIAESQVNKLR 1922



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 84/356 (23%), Positives = 160/356 (44%), Gaps = 52/356 (14%)

Query: 21   ANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDA-LSKRSKEAEAAFL 79
            + +Q E E++  +L  +  E      E    ++   L   + EID  ++++ +E E    
Sbjct: 1530 SRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR 1589

Query: 80   NVYKRLIDVPDPVPALDL-----GQQLQLKVQR---LHDIETE----NQKLRETLEEYNK 127
            N Y+R ++      ALD       + ++LK +    L++IE +    N++  ETL+    
Sbjct: 1590 N-YQRTVETMQS--ALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRS 1646

Query: 128  EFAEVKNQEVTIK-ALK--EKIREYEQTLKNQAETIALEKEQ-KLQNDFAEKERKLQETQ 183
               ++K+ ++ +  AL+  E ++E    ++ +A  +  E E+ +   +  E+ RKL E +
Sbjct: 1647 VQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQE 1706

Query: 184  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA 243
                  L ++  +VQ L T      T L   K K + +      E+E    D   A ++A
Sbjct: 1707 ------LLDSNERVQLLHTQ----NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKA 1756

Query: 244  EVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVE-LAAKEREIAQL 302
            + A  +A  + E+L     +     +++K  ++EQ ++ L     E E LA K  +    
Sbjct: 1757 KKAITDAAMMAEELKKEQDTSAHLERMKK--NLEQTVKDLQHRLDEAEQLALKGGK---- 1810

Query: 303  VEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKEL 358
             + +Q+L+   T++RE        LE +L  +    K+  E +KG   YE   KEL
Sbjct: 1811 -KQIQKLE---TRIRE--------LEFELEGEQ---KKNTESVKGLRKYERRVKEL 1851


>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
          Length = 284

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 75/291 (25%), Positives = 142/291 (48%), Gaps = 26/291 (8%)

Query: 64  IDALSKRSKEAEAAFLNVYKRLIDVP-DPVPALDLGQQLQLKV----QRLHDIETENQKL 118
           +DA+ K+ +  +    N   R      D   A D  +QL+ ++    ++L   E E  K 
Sbjct: 1   MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY 60

Query: 119 RETLEEYNK--EFAEVK--NQEVTIKALKEKIREYEQTLKNQAETIA--LEKEQKLQNDF 172
            E L++  +  E AE K  + E  + +L  +I+  E+ L    E +A  L+K ++ +   
Sbjct: 61  SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 120

Query: 173 AEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI 232
            E ER ++  +    S+ ++ E K++  +  L++ +    D   KY+E     A ++ +I
Sbjct: 121 DESERGMKVIE----SRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEV----ARKLVII 172

Query: 233 MTDLERANQRAEVAQREAETLREQLSSANHSLQ--LASQ---IQKAPDVEQAIEVLTRSS 287
            +DLERA +RAE+++ +   L EQL   + +L+  +A++    QK    E+ I+VL+   
Sbjct: 173 ESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKL 232

Query: 288 LEVELAAK--EREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNS 336
            E E  A+  ER + +L + +  L+  +   +E + S    L+Q L   N+
Sbjct: 233 KEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNN 283



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 54/227 (23%), Positives = 108/227 (47%), Gaps = 21/227 (9%)

Query: 153 LKNQAETIALEKEQKLQN-DFAEKERKLQETQMSTTS-KLEEAEHKVQSLQTALEKTRTE 210
           +K + + + L+KE  L   + AE ++K  E +      +L   + K++  +  L+K    
Sbjct: 4   IKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEA 63

Query: 211 LFDLKTKYD----EETTAKAD------EIEMIMTDLERANQRAEVAQREAETLREQLSSA 260
           L D + K +    + T A+AD       I+++  +L+RA +R   A ++ E   +    +
Sbjct: 64  LKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADES 123

Query: 261 NHSLQ-LASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLREN 319
              ++ + S+ QK  +  +  E+  + +  +   A +R+  ++   +  +++ L +  E 
Sbjct: 124 ERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDA-DRKYEEVARKLVIIESDLERAEER 182

Query: 320 ---SASQISQLEQQLSAKNSTLKQL---EEKLKGQAD-YEEVKKELN 359
              S  Q+ QLE+QL   + TLK L   E+K   + D YEE  K L+
Sbjct: 183 AELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLS 229


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 102/467 (21%), Positives = 203/467 (43%), Gaps = 67/467 (14%)

Query: 10   KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLK---SFQGEIDA 66
            +++L  T  VLA  ++ S+  +  L +     +K     L++++  L +   S   +I A
Sbjct: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK-----LQQELDQLNRDKLSLHNDISA 1854

Query: 67   LSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIE-TENQKLRETLEEY 125
            + ++ +E   A  ++ + L +V D    L+L +Q  L   +  D+  +E  +L++ + E+
Sbjct: 1855 MQQQLQEKREAVNSLQEELANVQDH---LNLAKQDLLHTTKHQDVLLSEQTRLQKDISEW 1911

Query: 126  NKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMS 185
               F + + +E T +                      ++ Q LQN+  E + KL + +M 
Sbjct: 1912 ANRFEDCQKEEETKQ----------------------QQLQVLQNEIEENKLKLVQQEM- 1948

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 245
                 +  + + +S ++ LE ++  L + + + ++E T +  +++ +++ +  A +R   
Sbjct: 1949 ---MFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRT 2005

Query: 246  AQRE---AETLREQLSSANHSLQLASQ-----------IQKAPDVEQAIEVLTRSSLEVE 291
             Q E    E+L + LS     L    Q           +QK  D  +A   L R+    E
Sbjct: 2006 LQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTE 2065

Query: 292  LAAKEREIAQLVE--DVQRLQAS---LTKLRENSASQISQLEQQLSAKNS---TLKQLEE 343
                E+++A L E   +QR Q     L + +ENS  Q      +L A+++     + ++E
Sbjct: 2066 RKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKE 2125

Query: 344  KLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNR-SLQSENAALRIS 402
              + Q +Y E+KK++   K +E    E     DA + L+  + ++ R SL++ N  L   
Sbjct: 2126 LNQMQYEYTELKKQMANQKDLERRQME---ISDAMRTLKSEVKDEIRTSLKNLNQFLPEL 2182

Query: 403  NSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTH 449
             +DL     R    + E     SL    P  +   P E+  N +  H
Sbjct: 2183 PADLEAILERNENLEGELE---SLKENLPFTMNEGPFEEKLNFSQVH 2226



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 77/359 (21%), Positives = 161/359 (44%), Gaps = 42/359 (11%)

Query: 10  KRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAP-----LLKSFQGEI 64
           ++++ A  T L+   DE E++ ++++  + EFK+       K+++      L K   G +
Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRL 502

Query: 65  DALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEE 124
             ++K  +EA    L + K+              Q++  K + + D++     L     +
Sbjct: 503 QLVNKLRQEALDLELQMEKQ-------------KQEIAGKQKEIKDLQIAIDSLDSKDPK 549

Query: 125 YNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQM 184
           ++   A+   +E  +  + ++ ++ E  L      IA E E     +  + E +L E Q+
Sbjct: 550 HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE-----EIKDLEEQLTEGQI 604

Query: 185 STTSKL-EEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMI---MTDLERAN 240
           +    L ++ E  +  LQ  L   + +     T+   E     DE E +   +T++E+  
Sbjct: 605 AANEALKKDLEGVISGLQEYLGTIKGQ----ATQAQNECRKLRDEKETLLQRLTEVEQER 660

Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIA 300
            + E+   +AE +R++L+    +LQ   ++  +    Q       + LE  L  ++ E  
Sbjct: 661 DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN 720

Query: 301 QLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELN 359
           QL E+++++   LT+L E SA Q ++LE++  A  + L        G+A + E K++ N
Sbjct: 721 QLKEELEKV-TRLTQL-EQSALQ-AELEKERQALKNAL--------GKAQFSEEKEQEN 768



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 75/373 (20%), Positives = 160/373 (42%), Gaps = 46/373 (12%)

Query: 14   DATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLR--KQVAPLLKSFQGEIDALSKR- 70
            D+    L+ ++++  +  ++L +     ++N    L+  K+   LL++ + E++ L  + 
Sbjct: 1530 DSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQV 1589

Query: 71   -SKEAEAAFLN------------VYKRLIDVP-DPVPALDLGQ-QLQLKVQRLHDIETEN 115
             S++ E A L+            +   ++    D   AL LG+ ++  K   + ++++  
Sbjct: 1590 TSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLL 1649

Query: 116  QKLRETLEEYNKEFAEVKNQEVTIKALKEKIRE-----------YEQTLKNQAETIALEK 164
            ++L     E N + +E K Q   IK   EK  E           ++  LKN  + + LE 
Sbjct: 1650 EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLEN 1709

Query: 165  EQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTA 224
             + LQ    + ++++ E + +  + LEE + ++++LQ   ++ + E+   K   + +   
Sbjct: 1710 HE-LQGLKLQHDQRVSELEKTQVAVLEE-KLELENLQQISQQQKGEIEWQKQLLERDKR- 1766

Query: 225  KADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLT 284
               EIE +  +        E   +E E L+E+       L    ++  A +    +E   
Sbjct: 1767 ---EIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSN 1823

Query: 285  RSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344
               LE+ +   ++E+ QL  D   L            + IS ++QQL  K   +  L+E+
Sbjct: 1824 LEKLELNVRKLQQELDQLNRDKLSLH-----------NDISAMQQQLQEKREAVNSLQEE 1872

Query: 345  LKGQADYEEVKKE 357
            L    D+  + K+
Sbjct: 1873 LANVQDHLNLAKQ 1885



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 79/366 (21%), Positives = 154/366 (42%), Gaps = 63/366 (17%)

Query: 25   DESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKR 84
            DE E   K L+++  E +         +   LL   + E+    +++K A   F +  + 
Sbjct: 1419 DEIECIEKTLLKRRSELR---------EADRLLAEAESELSCTKEKTKNAVEKFTDAKRS 1469

Query: 85   LIDVPDPVPALD------------LGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEV 132
            L+        L+              QQL+       D+E    K  E L+E NK  A  
Sbjct: 1470 LLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAK 1529

Query: 133  KNQEVTIKALKEKIREYEQTLKNQAE----------TIALEKEQKLQNDFAEKER----- 177
             +    +   KEK+ E  Q L+   E           +  E E  LQ   AE E+     
Sbjct: 1530 DSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQV 1589

Query: 178  KLQETQMSTTSK-LEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDL 236
              Q+ +M+   + L   + ++  LQ ++ + + +L +     + E T K + I  + + L
Sbjct: 1590 TSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLL 1649

Query: 237  ERANQRAEVAQREAETLREQLSSANHSLQLASQ-IQKAPDVEQAIEVLTRSSLEVELAAK 295
            E      E++ ++ E L  Q+S     L L  Q I+K    E+ ++V+ R     +++  
Sbjct: 1650 E------ELSFQKGE-LNVQISERKTQLTLIKQEIEKE---EENLQVVLR-----QMSKH 1694

Query: 296  EREIAQLVEDVQRLQASLTKLR--------ENSASQISQLEQQLSAKNSTLKQLEEKLKG 347
            + E+  +++ +Q     L  L+        E   +Q++ LE++L  +N  L+Q+ ++ KG
Sbjct: 1695 KTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN--LQQISQQQKG 1752

Query: 348  QADYEE 353
            + ++++
Sbjct: 1753 EIEWQK 1758



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 74/344 (21%), Positives = 150/344 (43%), Gaps = 44/344 (12%)

Query: 28   EQSRKRLIEQSREFKKNTPED-LRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLI 86
            ++ R++L   + E   ++P D L K +A L K F    + L++   E + A +   K   
Sbjct: 814  DELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFS---EILARSKWERDEAQVRERK--- 867

Query: 87   DVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKI 146
                      L +++ L+ ++L   + E ++  E   E    F + +  E  I+ ++ +I
Sbjct: 868  ----------LQEEMALQQEKLATGQEEFRQACERALEARMNF-DKRQHEARIQQMENEI 916

Query: 147  REYEQTLKNQAETIALEKEQKLQNDFAEKERKL-QETQMSTTSKLEEAEHKVQ--SLQTA 203
               ++ LK+  E   L   Q LQ    EKER L Q  ++    KLE+A+ + Q   L   
Sbjct: 917  HYLQENLKSMEEIQGLTDLQ-LQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975

Query: 204  LEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQ-RAEVAQ------REAETLREQ 256
            L+K +  +         E T   D+++ +   + + NQ RAE  Q      R+A      
Sbjct: 976  LKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARD 1035

Query: 257  LSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKL 316
            L+ A   ++L   + +    +  +E + ++ +     ++  EI +L E ++R +  + +L
Sbjct: 1036 LTRAEAEIELLQNLLRQKGEQFRLE-MEKTGVGTGANSQVLEIEKLNETMERQRTEIARL 1094

Query: 317  R--------------ENSASQISQLEQQLSAKNSTLKQLEEKLK 346
            +              EN   +I++L +++S +N  +  + +  K
Sbjct: 1095 QNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFK 1138



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 64/336 (19%), Positives = 149/336 (44%), Gaps = 44/336 (13%)

Query: 104  KVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALE 163
            K Q   ++E  +  + + L+E      EV+    T++  +++    +  +++    + +E
Sbjct: 1349 KRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE 1408

Query: 164  KEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDE--- 220
            K  K   D  ++   +++T +   S+L EA+  +   ++ L  T+ +  +   K+ +   
Sbjct: 1409 KSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKR 1468

Query: 221  ---ETTAKADEIEM----IMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKA 273
               +T + A+E+E        +L +A+Q+    Q +A+ L +        L+  ++I  A
Sbjct: 1469 SLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAA 1528

Query: 274  PD---------VEQAIEVLTRSSLEVELAAK-EREIAQLVED----VQRLQASLTKLREN 319
             D          E+  E L +   ++E+A + E    Q++++    +Q  +A L KL+  
Sbjct: 1529 KDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQ 1588

Query: 320  SASQ---ISQLEQQLSAKNSTLKQLE-EKLKGQADYEE---------------VKKELNI 360
              SQ   ++ L++QL  K   L  L+   ++ +AD +E               +++  ++
Sbjct: 1589 VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSL 1648

Query: 361  LKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSEN 396
            L+ + F   E    Q + +  ++ L+++    + EN
Sbjct: 1649 LEELSFQKGE-LNVQISERKTQLTLIKQEIEKEEEN 1683



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 74/370 (20%), Positives = 164/370 (44%), Gaps = 36/370 (9%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDAL 67
            RL++++   A    + Q E E  +++L     E ++N  + +++++  + +  Q E    
Sbjct: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM--MFQRLQKE---- 1956

Query: 68   SKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNK 127
                +E+E + L   K  +         +L  Q     Q L  +    +++R TL+E   
Sbjct: 1957 ----RESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVR-TLQE--- 2008

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTL-KNQAETIALEKE-QKLQNDFAEKERKLQETQMS 185
            E    ++ E T+   K ++ E EQ L +   E +AL+KE   ++ DF+     L   Q  
Sbjct: 2009 EERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFS-----LLRNQFL 2063

Query: 186  TTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEV 245
            T  K  +AE +V SL+ AL+  R++L     +  +E +    E+  I    +  ++RA  
Sbjct: 2064 TERK--KAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARR 2121

Query: 246  AQREAETLREQLSSANHSLQLASQIQKAP-DVEQAIEVLTRSSLEVELAAKEREIAQLVE 304
              +E   ++ + +     +     +++   ++  A+  L +S ++ E+    + + Q + 
Sbjct: 2122 LMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL-KSEVKDEIRTSLKNLNQFLP 2180

Query: 305  DV-----------QRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEE 353
            ++           + L+  L  L+EN    +++   +     S +  ++E  +G+A  E+
Sbjct: 2181 ELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREK 2240

Query: 354  VKKELNILKS 363
            ++   + LK+
Sbjct: 2241 LRHREDRLKA 2250



 Score = 40.4 bits (93), Expect = 0.013
 Identities = 74/328 (22%), Positives = 139/328 (42%), Gaps = 51/328 (15%)

Query: 93  PALDLGQQLQLKVQRLHDIET-ENQKL----------RETLEEYNKEFAEVKNQEVTIKA 141
           P + L   LQ  +  L  +E+ E Q +          R +LEE  +   +++ + +  + 
Sbjct: 229 PVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEE 288

Query: 142 LKEKIREYEQTLKNQ-------AETIALEKE--QKLQNDFAEKERKLQETQMSTTS---- 188
           LK K   + + +KNQ        E   L+K+  ++L++D   K   L++  +  T     
Sbjct: 289 LKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQK 348

Query: 189 ----KLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLER----AN 240
               + E A +K+ +    L    +E  ++    DE         +  M   E     + 
Sbjct: 349 QYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSA 408

Query: 241 QRAEVAQREA-ETLREQLSSANHSLQLASQIQKAPDVEQAIEVL-TR-SSLEVELAAKER 297
           Q  ++ + E  E LR    +      L +Q++   D E+ I    TR S L  E+   E+
Sbjct: 409 QAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLE---DKEKKISAAQTRLSELHDEIEKAEQ 465

Query: 298 EIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKE 357
           +I +  E+ ++L+ ++ +L++ S +    L +QLS +     QL  KL+ +A        
Sbjct: 466 QILRATEEFKQLEEAI-QLKKISEAGKDLLYKQLSGR----LQLVNKLRQEA-------- 512

Query: 358 LNILKSMEFAPSEGAGTQDAAKPLEVLL 385
           L++   ME    E AG Q   K L++ +
Sbjct: 513 LDLELQMEKQKQEIAGKQKEIKDLQIAI 540



 Score = 35.0 bits (79), Expect = 0.55
 Identities = 53/241 (21%), Positives = 99/241 (41%), Gaps = 40/241 (16%)

Query: 17   ATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPL--LKSFQGEI-DALSKRSKE 73
            AT+    QD  E++R+ + E ++   + T  +L+KQ+A    L+  Q EI DA+     E
Sbjct: 2106 ATIELVAQDNHERARRLMKELNQMQYEYT--ELKKQMANQKDLERRQMEISDAMRTLKSE 2163

Query: 74   AEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETL----------E 123
             +       K L      +PA      L+  ++R  ++E E + L+E L          E
Sbjct: 2164 VKDEIRTSLKNLNQFLPELPA-----DLEAILERNENLEGELESLKENLPFTMNEGPFEE 2218

Query: 124  EYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ 183
            + N     + ++    +AL+EK+R  E  LK Q           L++  +++   L + +
Sbjct: 2219 KLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ-----------LRHCMSKQAEVLIKGK 2267

Query: 184  MSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRA 243
              T   L     +V +L   +  T           D  ++    ++E  +T+  +  Q  
Sbjct: 2268 RQTEGTLHSLRRQVDALGELVTSTSA---------DSASSPSLSQLESSLTEDSQLGQNQ 2318

Query: 244  E 244
            E
Sbjct: 2319 E 2319


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 103/463 (22%), Positives = 184/463 (39%), Gaps = 69/463 (14%)

Query: 8   RLKRELDATATVLANRQDESEQS---------RKRLIEQSREFKKNTPEDLRKQVAPLLK 58
           RL  EL+  ATV+ + + E  Q          +K L++        T E  R+      +
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES-----E 249

Query: 59  SFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKL 118
             + E   L  +   +EA    +   L   P  V      Q+LQ     ++++  +NQ L
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYV--QELQKLKSSVNELTQKNQTL 307

Query: 119 RETL-----------EEYNKEFAEVKNQEVTI-------KALKEKIREYEQTLKNQAETI 160
            E L           E++N+E    KN + T+       + L+ ++   E +L      +
Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367

Query: 161 ALEKE--QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQ---SLQTALEKTRTELFDLK 215
           + + E  QKL+ + +E E K Q  +       ++ E K Q    LQ+ + +  ++L + +
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427

Query: 216 TKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSS-ANHSLQLASQIQKAP 274
            +  E      ++ ++    L    Q+    Q +   L EQL     +S +L  Q+ K  
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487

Query: 275 DVEQAIEVLTRSSL------EVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLE 328
              Q  + L +S+       + +L    R+I    + +Q L+A L K +EN +    + E
Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547

Query: 329 Q----------------QLSAKNSTLK----QLEEKLKGQADYEEVKKELNILKSMEFAP 368
                            QL  KN TL+    QL EKLK Q++  +  +E N+   ++   
Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE-NLHDQVQEQK 606

Query: 369 SEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSAR 411
           +     QD    LE  + E N  L       ++S  D+   A+
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLNESKE--KVSQLDIQIKAK 647



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 90/433 (20%), Positives = 183/433 (42%), Gaps = 58/433 (13%)

Query: 8    RLKRELDATATVLANRQDESEQSRKRLIEQSREFK--KNTPEDLRKQVAPLLKSFQGEID 65
            ++  +LD     L ++Q+   Q    L E   ++   +   E+L  Q+  L      E D
Sbjct: 685  KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL------EAD 738

Query: 66   ALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEY 125
            +L  ++ + +A      +R ++    + A +L +QL+++ + +     + QK  E LE  
Sbjct: 739  SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798

Query: 126  NKEFAEVKNQEVTIK----ALKEKIREYEQTLKNQAET-------IALEKE--------- 165
             ++  + + ++  +K     L ++ +   + L N+ +T       + +EKE         
Sbjct: 799  KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858

Query: 166  --------QKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTK 217
                      L+N  +E E++ Q+ + +     +  +     LQ  +E T  E  +LK  
Sbjct: 859  KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918

Query: 218  YDEETTAKAD---EIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAP 274
             ++E  A      E+  +   L +A    +  ++E + L+  ++    S +   +  +A 
Sbjct: 919  LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978

Query: 275  DVEQAIEVLTRSSLE-----------VELAAKEREIAQLVEDVQRLQASLTKLRENSASQ 323
              E  I VL ++ LE            ELAA++ +I+ L  + ++ Q +  +L+    S 
Sbjct: 979  QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ----SD 1034

Query: 324  ISQLEQQLSAKNSTLKQLEEKLK-GQADYEEVKKELNILKSM--EFAPSEGAGTQDAAKP 380
                E +L A    LK +EEKL   Q D    + ++     +  E   ++    QD+AK 
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK 1094

Query: 381  LEVLLLEKNRSLQ 393
             E  L E+ ++LQ
Sbjct: 1095 -EQQLQERCKALQ 1106



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 95/410 (23%), Positives = 184/410 (44%), Gaps = 58/410 (14%)

Query: 23   RQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVY 82
            +Q+E +Q  K+  E   +  K   E+L  ++   +   Q       K  KEA    L+  
Sbjct: 804  KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKV-----KMEKEALMTELSTV 858

Query: 83   K-RLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQ-----E 136
            K +L  V D            LK  +  + E ENQK +  + +  K   E+K+Q     E
Sbjct: 859  KDKLSKVSD-----------SLKNSK-SEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906

Query: 137  VTIKALKE--KIREYEQTLKNQAETIALEKEQKL---QNDFAEKERKLQETQMSTTSKLE 191
             T+K  KE  K  E E+   +Q +      +++L   QN   + E++ Q+ Q +     +
Sbjct: 907  NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966

Query: 192  EAEHK---VQSLQ-----TALEKTRTE--LFDLKTKYDEETTAKADEIEMIMTDLERANQ 241
             +E K   +++LQ       L+KT  E  L    T+  +E  A+ ++I ++  + E++ +
Sbjct: 967  SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026

Query: 242  RAEVAQ-----REAETL--REQLSSANHSLQLA--------SQIQKAPDVEQAIEVLTRS 286
              +  Q     RE+E L  R+ L S    L LA        +QI     + Q ++   ++
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT-AKA 1085

Query: 287  SLEVELAAKEREI---AQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEE 343
            +LE + A KE+++    + ++D+Q+ ++   K   N  S+++++E+    +   + +L E
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145

Query: 344  KLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQ 393
            +LK     E +K+  N+  + +    +    Q  A  L+  + ++ R+ Q
Sbjct: 1146 ELKSH-KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 149/709 (21%), Positives = 279/709 (39%), Gaps = 122/709 (17%)

Query: 98   GQQLQLKVQRLHD--IETENQ--KLRETLEEYNKEFAE-VKNQEVTIKALKEKIREYEQT 152
            G QLQ ++ +LH   +ETE Q  +    L+E  +  +E + ++E  +  L+ K+   E+ 
Sbjct: 409  GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 468

Query: 153  LKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEH--------------KVQ 198
            LK +  T + E + +L     ++ ++ Q  Q STT+KL EA++              K+Q
Sbjct: 469  LKEKV-TNSTELQHQLDKT-KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526

Query: 199  SLQ----------TALEKTRTELFDLKTKYDEETTAKADEI--------EMIMTDLERAN 240
            +L+          + LEK R +L+  K +  E  TA  +++        E +    E+  
Sbjct: 527  NLEALLQKSKENISLLEKEREDLY-AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585

Query: 241  QRAEVAQREAETLREQLSSANHSL---------------QLASQIQKAPDVEQAIEVLTR 285
             ++E  ++  E L +Q+      L               +L SQ+ ++ +    +++  +
Sbjct: 586  NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 645

Query: 286  SSLEVELAAKEREIAQLVEDVQRLQASLTKLRENS------ASQISQLEQQLSAKNSTLK 339
            +  E+ L+A+  + AQ  +    L  +   L++         +Q+ Q+  +L  K     
Sbjct: 646  AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705

Query: 340  QLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAAL 399
            QLE  LK   +Y+E  K L++ +  E    EG   +  A  LEV    K ++LQ      
Sbjct: 706  QLESHLK---EYKE--KYLSLEQKTE--ELEGQIKKLEADSLEV-KASKEQALQDLQQQR 757

Query: 400  RISNSDLSGSARRKGKD---QPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGL 456
            ++ N+DL   A    K    + E      L     S+   +  ++ +      Q     L
Sbjct: 758  QL-NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI----L 812

Query: 457  SQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNS 516
             QDF + S  +            LN+ +Q  + +    K  +EA  T +  ST     + 
Sbjct: 813  KQDFETLSQET------KIQHEELNNRIQTTVTELQKVKMEKEALMTEL--STVKDKLSK 864

Query: 517  ISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGH 576
            +S           + +  S S+ E      +   +D  +  +++K QL            
Sbjct: 865  VS-----------DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL------------ 901

Query: 577  YVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQ 636
                  Q  +   L   K   K   + KE  H++K  L+  Q  L       +Q E   Q
Sbjct: 902  ------QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955

Query: 637  SL----NRLFQEVPKRRNGSE---GNITTRIRASETGSDEAIKSILEQAKRELQVQKTAE 689
             L    N L Q   +++   E   G +   +   +T  +  ++  L QA +EL  +K   
Sbjct: 956  QLQGNINELKQSSEQKKKQIEALQGELKIAV-LQKTELENKLQQQLTQAAQELAAEKEKI 1014

Query: 690  PAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDI 738
                ++   S  +   ++S       E+ A +  L    ++  L+Q D+
Sbjct: 1015 SVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 68/290 (23%), Positives = 132/290 (45%), Gaps = 43/290 (14%)

Query: 89  PDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVT-IKALKEKIR 147
           P  + +L    +L    + +HD   ++    E+     ++   +  QEV  ++A  ++ +
Sbjct: 44  PQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEK 103

Query: 148 EYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQ---MSTTSKLEEAEHK---VQSLQ 201
            Y + LK +     LEK Q LQ   A+ +  + ++     S   +LEEA+ +   ++ ++
Sbjct: 104 WYSEELKKE-----LEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158

Query: 202 TALEKTR----TELFDLKTKYDEETTAK-----------------ADEIEMIMTDLERAN 240
              E+      TE+ D+K+KYDEE + +                 A  I+ + T+L +  
Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP 218

Query: 241 QRAEVAQREAETLREQLSSANHSLQLASQIQKAPD------VEQAIEVLTRSSLEVELAA 294
              +VA  + E ++ Q    N +L+   + +K  D       + A    T S L  ELA 
Sbjct: 219 GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK 278

Query: 295 KEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEK 344
             +E+A  V+++Q+L++S+ +L + + +    L + L  K     +LEEK
Sbjct: 279 GPQEVAVYVQELQKLKSSVNELTQKNQT----LTENLLKKEQDYTKLEEK 324



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 141/714 (19%), Positives = 288/714 (40%), Gaps = 88/714 (12%)

Query: 24   QDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGE---IDALSKRSKEAEAAFLN 80
            +D+  Q+ + L+++S+E   +  E  R+ +   +++ +GE   ++ L +++   +     
Sbjct: 521  KDQKIQNLEALLQKSKE-NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQ 579

Query: 81   VYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQ--KLRETLEEYNKEFAEVKNQ--- 135
            + ++L +  +           Q++ Q+ H    +++   L  ++ E N +  E K +   
Sbjct: 580  LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 639

Query: 136  -EVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMST---TSKLE 191
             ++ IKA  E        L   AE     +   LQN     +  LQ+ Q      T++L+
Sbjct: 640  LDIQIKAKTE--------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 691

Query: 192  EAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAE 251
            +   K+Q  Q    +  + L + K KY      K +E+E  +  LE  +   + ++ +A 
Sbjct: 692  QVTAKLQDKQEHCSQLESHLKEYKEKY-LSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750

Query: 252  TLREQLSSANHSLQL-ASQIQKAPDVEQAIEVLTRSSLEVELAAKE---REIAQLVEDVQ 307
               +Q    N  L+L A+++ K  ++E+ I   TR  L+ +  A E   +++ +  E+ Q
Sbjct: 751  QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810

Query: 308  RLQASLTKLRENSASQISQLEQQLSAKNSTLKQLE-EKLKGQADYEEVKKELN-ILKSME 365
             L+     L + +  Q  +L  ++    + L++++ EK     +   VK +L+ +  S++
Sbjct: 811  ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870

Query: 366  FAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGS 425
             + SE        K   +L LEK          +++ N+ L      K   + E      
Sbjct: 871  NSKSEFEKENQKGK-AAILDLEKTCKELKHQLQVQMENT-LKEQKELKKSLEKEKEASHQ 928

Query: 426  LPAPPPSQ----------LPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLAST 475
            L     S           L +N  E+       ++   +   +     +L    L +A  
Sbjct: 929  LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG-ELKIAVL 987

Query: 476  GKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPS 535
             K  L + LQ+QL Q     A QE  +     S      N   SQ   +Q          
Sbjct: 988  QKTELENKLQQQLTQ-----AAQELAAEKEKISV--LQNNYEKSQETFKQ---------- 1030

Query: 536  PSQSESAGSVSEGEEMDTAEIARQVKEQLI---------KHNIGQRIFGHYVLGLSQGSV 586
              QS+  G   E E + T +  + V+E+L          ++ IG +      L  ++ ++
Sbjct: 1031 -LQSDFYG--RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087

Query: 587  SEILARPKPWNKLTVRG-----KEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRL 641
             +  A+ +   +   +      KE   K K+ ++++  +  +  I+ RQ     + + +L
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE----KEITKL 1143

Query: 642  FQEVPKRRNGSEGNITTRIRASE---------TGSDEAIKSILEQAKRELQVQK 686
             +E+   +  S   IT    A +          G  +++K+ +EQ KR  Q+ K
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK 1197



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 67/321 (20%), Positives = 138/321 (42%), Gaps = 43/321 (13%)

Query: 15   ATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEA 74
            A   +++NR     Q++  LI++ +  K    +D  K+   L +  +   D   ++S + 
Sbjct: 1059 AQEDLISNRNQIGNQNK--LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK- 1115

Query: 75   EAAFLNVYKRLIDVPDPVPALDLGQQLQ-------LKVQRLHDIETENQKLRETLEEYNK 127
            E   +N   +L ++ +    +   Q+ +       LK  +L  I+ E   L++  +   +
Sbjct: 1116 EKELVNEKSKLAEIEE----IKCRQEKEITKLNEELKSHKLESIK-EITNLKDAKQLLIQ 1170

Query: 128  EFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTT 187
            +  E++ +  ++KA  E+ +  +Q LK+Q +    ++E++L+ +F EKE KL        
Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVK----KEEEELKKEFIEKEAKLHSEIKEKE 1226

Query: 188  SKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQ 247
              +++ E     L   +      L  +K ++ + +  +  E+E    DL     R E+A 
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEW-QSSQRRVSELEKQTDDL-----RGEIAV 1280

Query: 248  REAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQ 307
             EA       +  N+  +  + +++    E  IE L    LE+     +R++      VQ
Sbjct: 1281 LEA-------TVQNNQDERRALLERCLKGEGEIEKLQTKVLEL-----QRKLDNTTAAVQ 1328

Query: 308  RLQASLTKLRENSASQISQLE 328
             L       REN + QI   +
Sbjct: 1329 ELG------RENQSLQIKHTQ 1343



 Score = 31.2 bits (69), Expect = 7.9
 Identities = 28/148 (18%), Positives = 69/148 (46%), Gaps = 9/148 (6%)

Query: 220 EETTAKADEIEMIMTDLERANQRAEVAQREAETLRE-QLSSANHSLQLASQIQKAPDVEQ 278
           ++ T    E++ +   L+     +E  ++E E  +  Q   A     +     +   +EQ
Sbjct: 83  DDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQ 142

Query: 279 AIEVLTRSSLEVELAAK--EREIAQLVEDVQRLQASLTK---LRENSASQISQLEQQLSA 333
            +E     +  ++      E++ AQL  ++  +++   +   LRE +  ++++L ++L+ 
Sbjct: 143 QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202

Query: 334 KNSTLKQLEEKLKGQADYEEV---KKEL 358
           + + ++ L+ +L  +   E+V   KKEL
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKEL 230


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.124    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,059,693
Number of Sequences: 37866
Number of extensions: 3620524
Number of successful extensions: 56480
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 750
Number of HSP's successfully gapped in prelim test: 2698
Number of HSP's that attempted gapping in prelim test: 27521
Number of HSP's gapped (non-prelim): 22882
length of query: 1505
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1390
effective length of database: 13,892,928
effective search space: 19311169920
effective search space used: 19311169920
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.