Guide to the Human Genome
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Search of human proteins with 145309302

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo
sapiens]
         (1512 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]   3017   0.0  
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]   2818   0.0  
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   987   0.0  
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   980   0.0  
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]                   290   7e-78
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    253   1e-66
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   252   2e-66
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      249   2e-65
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   248   2e-65
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   248   3e-65
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   248   3e-65
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    246   1e-64
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   243   8e-64
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   243   1e-63
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   242   2e-63
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        237   7e-62
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             232   2e-60
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        232   2e-60
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           231   5e-60
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   223   1e-57
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        217   6e-56
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          217   6e-56
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]         216   1e-55
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         215   3e-55
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         215   3e-55
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   214   7e-55
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   206   1e-52
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      204   5e-52
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      204   7e-52
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    200   1e-50

>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score = 3017 bits (7821), Expect = 0.0
 Identities = 1512/1512 (100%), Positives = 1512/1512 (100%)

Query: 1    MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60
            MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF
Sbjct: 1    MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60

Query: 61   LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120
            LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV
Sbjct: 61   LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120

Query: 121  FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180
            FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS
Sbjct: 121  FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180

Query: 181  PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240
            PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE
Sbjct: 181  PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240

Query: 241  ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300
            ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY
Sbjct: 241  ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300

Query: 301  REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360
            REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS
Sbjct: 301  REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360

Query: 361  PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
            PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS
Sbjct: 361  PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420

Query: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
            RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA
Sbjct: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480

Query: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540
            EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK
Sbjct: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540

Query: 541  PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600
            PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV
Sbjct: 541  PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600

Query: 601  ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660
            ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD
Sbjct: 601  ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660

Query: 661  LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720
            LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY
Sbjct: 661  LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720

Query: 721  KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780
            KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF
Sbjct: 721  KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780

Query: 781  KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840
            KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC
Sbjct: 781  KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840

Query: 841  SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900
            SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC
Sbjct: 841  SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900

Query: 901  GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960
            GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL
Sbjct: 901  GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960

Query: 961  REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020
            REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL
Sbjct: 961  REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020

Query: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVK 1080
            WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVK
Sbjct: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVK 1080

Query: 1081 TGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGE 1140
            TGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGE
Sbjct: 1081 TGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGE 1140

Query: 1141 KQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKD 1200
            KQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKD
Sbjct: 1141 KQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKD 1200

Query: 1201 VLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQR 1260
            VLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQR
Sbjct: 1201 VLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQR 1260

Query: 1261 PPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGG 1320
            PPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGG
Sbjct: 1261 PPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGG 1320

Query: 1321 IDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNY 1380
            IDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNY
Sbjct: 1321 IDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNY 1380

Query: 1381 STASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANS 1440
            STASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANS
Sbjct: 1381 STASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANS 1440

Query: 1441 SDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHIST 1500
            SDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHIST
Sbjct: 1441 SDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHIST 1500

Query: 1501 STGRGRGRGLPY 1512
            STGRGRGRGLPY
Sbjct: 1501 STGRGRGRGLPY 1512


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score = 2818 bits (7306), Expect = 0.0
 Identities = 1436/1514 (94%), Positives = 1441/1514 (95%), Gaps = 64/1514 (4%)

Query: 1    MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60
            MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF
Sbjct: 1    MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60

Query: 61   LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120
            LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV
Sbjct: 61   LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120

Query: 121  FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180
            FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS
Sbjct: 121  FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180

Query: 181  PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240
            PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE
Sbjct: 181  PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240

Query: 241  ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300
            ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY
Sbjct: 241  ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300

Query: 301  REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360
            REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS
Sbjct: 301  REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360

Query: 361  PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
            PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS
Sbjct: 361  PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420

Query: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
            RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA
Sbjct: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480

Query: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540
            EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK
Sbjct: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540

Query: 541  PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600
            PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV
Sbjct: 541  PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600

Query: 601  ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660
            ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD
Sbjct: 601  ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660

Query: 661  LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720
            LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY
Sbjct: 661  LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720

Query: 721  KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780
            KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF
Sbjct: 721  KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780

Query: 781  KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840
            KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC
Sbjct: 781  KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840

Query: 841  SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900
            SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC
Sbjct: 841  SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900

Query: 901  GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960
            GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL
Sbjct: 901  GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960

Query: 961  REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020
            REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL
Sbjct: 961  REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020

Query: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAP-- 1078
            WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAP  
Sbjct: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPGE 1080

Query: 1079 VKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILAT 1138
             +T P                                    S  QQ+ +K   P G +  
Sbjct: 1081 KQTDP------------------------------------STPQQESSK---PLGGI-- 1099

Query: 1139 GEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQ 1198
                       Q SS+    IQP       KVETDAAQAAVQSAFAVLLTQLIKAQQSKQ
Sbjct: 1100 -----------QPSSQT---IQP-------KVETDAAQAAVQSAFAVLLTQLIKAQQSKQ 1138

Query: 1199 KDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPD 1258
            KDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPD
Sbjct: 1139 KDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPD 1198

Query: 1259 QRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKRE 1318
            QRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKRE
Sbjct: 1199 QRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKRE 1258

Query: 1319 GGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLD 1378
            GGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLD
Sbjct: 1259 GGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLD 1318

Query: 1379 NYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLA 1438
            NYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLA
Sbjct: 1319 NYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLA 1378

Query: 1439 NSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHI 1498
            NSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHI
Sbjct: 1379 NSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHI 1438

Query: 1499 STSTGRGRGRGLPY 1512
            STSTGRGRGRGLPY
Sbjct: 1439 STSTGRGRGRGLPY 1452


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  987 bits (2552), Expect = 0.0
 Identities = 667/1528 (43%), Positives = 827/1528 (54%), Gaps = 247/1528 (16%)

Query: 134  ASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEG 193
            AS G  + PLVEY+D+SS S+                             S     + + 
Sbjct: 61   ASLGTVIKPLVEYDDISSDSD---------------------------TFSDDMAFKLDR 93

Query: 194  SERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSS 253
             E   RR    S    K RH +HRR        +  K +S+   S     +   SGSS  
Sbjct: 94   RENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKR 153

Query: 254  SGGRRKS-ASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYR- 311
            S         A  + SSS++ R SK H+ +T+  +E  S +K+  K++R+ +T PK+Y+ 
Sbjct: 154  SNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRET-PKSYKT 212

Query: 312  ----RRRSLSP------LGGRDDSPV--------------SHRASQSLRSRKSPSPAGG- 346
                +RRS SP         +DDSP               SH +S     +KSP      
Sbjct: 213  VDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRR 272

Query: 347  ------------------GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYS 388
                                SPYSRR  RS SPYSRRRS SY R  SY      SPSPY 
Sbjct: 273  QSVSPPYKEPSAYQSSTRSPSPYSRR-QRSVSPYSRRRSSSYERSGSYSGR---SPSPYG 328

Query: 389  SSSWRRSRSPY--------SPV-LRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSIS 439
                RRS SP+        SP+  R+S KSRSRSP  SRHS S S+ + S SRSRHSSIS
Sbjct: 329  R---RRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSIS 385

Query: 440  PSTLTLKSSLAAELNKNKKARA--AEAAR--------------------------AAEAA 471
            P  L L SSL AEL++ KK RA  A AA+                            E+ 
Sbjct: 386  PVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESK 445

Query: 472  KAAEATKAAEAA--AKAAKASNTSTPTKGNTETSA----SASQTNHVKDVKK-------- 517
            K   + K  ++A   +    ++ +T  K +++T        S+ + VKD+K         
Sbjct: 446  KLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKP 505

Query: 518  --------------------------IKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENN 551
                                      I     P P++    +       PP+     +  
Sbjct: 506  IALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPP 565

Query: 552  LIVDKATKKAVIVGKESK---SAATKEESVSLKEKTKPLTPSIGAKEKEQHVALV----T 604
            L   +     V     S    S  +K  +VS +  ++P    +  K +    A +    T
Sbjct: 566  LPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPV-QVSVKTQVSVTAAIPHLKT 624

Query: 605  STLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGD-DLSK 663
            STLPPLPLPP+LP D + DS +  +  K VKKE E++ R LL DLPLPPELPGGD     
Sbjct: 625  STLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPD 684

Query: 664  SPEEKK-TATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKA 722
            SPE K  T  Q   K+RPKIC PRYGE ++ + DWGKRCVDKFDIIGIIGEGTYGQVYKA
Sbjct: 685  SPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKA 744

Query: 723  RDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKK 782
            +DKDTGE+VALKKVRLDNEKEGFPITAIREIKILRQL H+S++NMKEIVTDK+DALDFKK
Sbjct: 745  KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKK 804

Query: 783  DKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSN 842
            DKGAFYLVFEYMDHDLMGLLESGLVHF+E+HIKSFM+QLMEGL+YCHKKNFLHRDIKCSN
Sbjct: 805  DKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSN 864

Query: 843  ILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 902
            ILLNN GQIKLADFGLARLY+SEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
Sbjct: 865  ILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 924

Query: 903  ILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLRE 962
            ILGELFTKKPIFQAN ELAQLELISR+CGSPCPAVWPDVIKLPYFNTMKPKKQYRR+LRE
Sbjct: 925  ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLRE 984

Query: 963  EFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWS 1022
            EF FIP+AALDL D+ML LDPSKRCTAEQ LQ +FL+DVE SKM PPDLP WQDCHELWS
Sbjct: 985  EFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWS 1044

Query: 1023 KKRRRQKQMG-MTDDVSTIKAPRKDLSLG--LDDSRTNTPQGVLPSSQLKSQGSSNVAPV 1079
            KKRRRQ+Q G + ++    K  RK+ + G   +  + ++P    P+      G+ +   +
Sbjct: 1045 KKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL 1104

Query: 1080 KTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGIL--A 1137
                 Q LN SELA+LLNLLQS+T +++    Q+LNI  N E QQQL  +N     L  A
Sbjct: 1105 -ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEA 1163

Query: 1138 TGEKQTDPSTPQQESSKPLGG---IQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQ 1194
            T ++Q   +   +ES K       I PS++  Q  +E  +  A +Q+  AVLL+QL+K Q
Sbjct: 1164 TSQQQDSETMAPEESLKEAPSAPVILPSAE--QTTLEASSTPADMQNILAVLLSQLMKTQ 1221

Query: 1195 QSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRI 1254
            +       LEE  +          R P  P    +                      P I
Sbjct: 1222 EPAGS---LEENNSDKNSGPQGPRRTPTMPQEEAAACP-------------------PHI 1259

Query: 1255 LPPDQRPPE------PPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQ 1308
            LPP++RPPE      PP PPP+ E DL            SS+  + +  V AALLQLL+ 
Sbjct: 1260 LPPEKRPPEPPGPPPPPPPPPLVEGDL------------SSAPQELNPAVTAALLQLLS- 1306

Query: 1309 HQPQDDPKREGGIDYQAGDTYVSTSDYKDN--FGSSSFSSAPYVSNDGLGSSSAPPLERR 1366
             QP+ +P      ++QA      ++  + N  +G++      + + D    +S P L   
Sbjct: 1307 -QPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALT-- 1363

Query: 1367 SFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHR 1426
                 S +Q+L    T             FS S   S  G    Y   G + F GD+D R
Sbjct: 1364 ----ESLVQTLVKNRT-------------FSGSL--SHLGESSSYQGTGSVQFPGDQDLR 1404

Query: 1427 FEYSHGPIAVLANSSDPSTGPE--STHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSP 1484
            F  +  P+A+      P    E  S   + A+    NYG          S   G  W  P
Sbjct: 1405 F--ARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGP 1462

Query: 1485 AQGPGYSQGYRGHISTSTGRGRGRGLPY 1512
             Q   Y + YRG        GRGRG+PY
Sbjct: 1463 TQSSAYGKLYRGPTRVPPRGGRGRGVPY 1490



 Score = 36.6 bits (83), Expect = 0.19
 Identities = 89/417 (21%), Positives = 148/417 (35%), Gaps = 56/417 (13%)

Query: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKE----PPSAYK-- 294
           ER    K GS  +SG  + S+   SS+S  R    SK  R ++K SK+     P A    
Sbjct: 5   ERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLG 64

Query: 295 ---EPPKAYREDKTEPKAY---------RRRRSLSPLGGRDDSPVSHRASQSLRSRKSPS 342
              +P   Y +  ++   +         RR         R D    HR  Q  RSR    
Sbjct: 65  TVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR-DLL 123

Query: 343 PAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPV 402
            A       S+ +         R S S  R  S E   D   +  + SS + SR   S  
Sbjct: 124 KAKQTEKEKSQEVSSKSGSMKDRISGSSKR--SNEETDDYGKAQVAKSSSKESR---SSK 178

Query: 403 LRRSGKSRSRSPYSSRHSRSRSRHRLS-------------RSRSRHSSISPSTLTLKSSL 449
           L +    + R   S    RS+S  +               RSRS H   S S+    S  
Sbjct: 179 LHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPS 238

Query: 450 AAELNKN---KKARAAEAARAAEAAKAAEATKAAEAAA-----KAAKASNTSTPTK-GNT 500
            A   ++     +R+  ++      K+  +T   ++ +      +A  S+T +P+     
Sbjct: 239 GASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRR 298

Query: 501 ETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKND------KAKTKPPLQVTKVENNLIV 554
           + S S          ++       SPS  G  ++       ++ ++ PL   K   +   
Sbjct: 299 QRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358

Query: 555 DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGA----KEKEQHVALVTSTL 607
             A  +      + K ++++    S+     PL  S+GA    K+KE+  A   + +
Sbjct: 359 SPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKM 415


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  980 bits (2533), Expect = 0.0
 Identities = 666/1522 (43%), Positives = 827/1522 (54%), Gaps = 244/1522 (16%)

Query: 134  ASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEG 193
            AS G  + PLVEY+D+SS S+                             S     + + 
Sbjct: 61   ASLGTVIKPLVEYDDISSDSD---------------------------TFSDDMAFKLDR 93

Query: 194  SERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSS 253
             E   RR    S    K RH +HRR        +  K +S+   S     +   SGSS  
Sbjct: 94   RENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKR 153

Query: 254  SGGRRKS-ASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYR- 311
            S         A  + SSS++ R SK H+ +T+  +E  S +K+  K++R+ +T PK+Y+ 
Sbjct: 154  SNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRET-PKSYKT 212

Query: 312  ----RRRSLSP------LGGRDDSPV--------------SHRASQSLRSRKSPSPAGG- 346
                +RRS SP         +DDSP               SH +S     +KSP      
Sbjct: 213  VDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRR 272

Query: 347  ------------------GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYS 388
                                SPYSRR  RS SPYSRRRS SY R  SY      SPSPY 
Sbjct: 273  QSVSPPYKEPSAYQSSTRSPSPYSRR-QRSVSPYSRRRSSSYERSGSYSGR---SPSPYG 328

Query: 389  SSSWRRSRSPY--------SPV-LRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSIS 439
                RRS SP+        SP+  R+S KSRSRSP  SRHS S S+ + S SRSRHSSIS
Sbjct: 329  R---RRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSIS 385

Query: 440  PSTLTLKSSLAAELNKNKKARA--AEAAR--------------------------AAEAA 471
            P  L L SSL AEL++ KK RA  A AA+                            E+ 
Sbjct: 386  PVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESK 445

Query: 472  KAAEATKAAEAA--AKAAKASNTSTPTKGNTETSA----SASQTNHVKDVKK-------- 517
            K   + K  ++A   +    ++ +T  K +++T        S+ + VKD+K         
Sbjct: 446  KLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKP 505

Query: 518  --------------------------IKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENN 551
                                      I     P P++    +       PP+     +  
Sbjct: 506  IALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPP 565

Query: 552  LIVDKATKKAVIVGKESK---SAATKEESVSLKEKTKPLTPSIGAKEKEQHVALV----T 604
            L   +     V     S    S  +K  +VS +  ++P    +  K +    A +    T
Sbjct: 566  LPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPV-QVSVKTQVSVTAAIPHLKT 624

Query: 605  STLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGD-DLSK 663
            STLPPLPLPP+LP D + DS +  +  K VKKE E++ R LL DLPLPPELPGGD     
Sbjct: 625  STLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPD 684

Query: 664  SPEEKK-TATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKA 722
            SPE K  T  Q   K+RPKIC PRYGE ++ + DWGKRCVDKFDIIGIIGEGTYGQVYKA
Sbjct: 685  SPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKA 744

Query: 723  RDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKK 782
            +DKDTGE+VALKKVRLDNEKEGFPITAIREIKILRQL H+S++NMKEIVTDK+DALDFKK
Sbjct: 745  KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKK 804

Query: 783  DKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSN 842
            DKGAFYLVFEYMDHDLMGLLESGLVHF+E+HIKSFM+QLMEGL+YCHKKNFLHRDIKCSN
Sbjct: 805  DKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSN 864

Query: 843  ILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 902
            ILLNN GQIKLADFGLARLY+SEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
Sbjct: 865  ILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 924

Query: 903  ILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLRE 962
            ILGELFTKKPIFQAN ELAQLELISR+CGSPCPAVWPDVIKLPYFNTMKPKKQYRR+LRE
Sbjct: 925  ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLRE 984

Query: 963  EFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWS 1022
            EF FIP+AALDL D+ML LDPSKRCTAEQ LQ +FL+DVE SKM PPDLP WQDCHELWS
Sbjct: 985  EFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWS 1044

Query: 1023 KKRRRQKQMG-MTDDVSTIKAPRKDLSLG--LDDSRTNTPQGVLPSSQLKSQGSSNVAPV 1079
            KKRRRQ+Q G + ++    K  RK+ + G   +  + ++P    P+      G+ +   +
Sbjct: 1045 KKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL 1104

Query: 1080 KTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGIL--A 1137
                 Q LN SELA+LLNLLQS+T +++    Q+LNI  N E QQQL  +N     L  A
Sbjct: 1105 -ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEA 1163

Query: 1138 TGEKQTDPSTPQQESSKPLGG---IQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQ 1194
            T ++Q   +   +ES K       I PS++  Q  +E  +  A +Q+  AVLL+QL+K Q
Sbjct: 1164 TSQQQDSETMAPEESLKEAPSAPVILPSAE--QTTLEASSTPADMQNILAVLLSQLMKTQ 1221

Query: 1195 QSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRI 1254
            +       LE  EN S   +     P     TP   Q++  + +        PEP     
Sbjct: 1222 EPAGS---LE--ENNSDKNSG----PQGPRRTPTMPQEEAAEKR-------PPEP----- 1260

Query: 1255 LPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDD 1314
                  PP PP PPP+ E DL            SS+  + +  V AALLQLL+  QP+ +
Sbjct: 1261 ----PGPPPPPPPPPLVEGDL------------SSAPQELNPAVTAALLQLLS--QPEAE 1302

Query: 1315 PKREGGIDYQAGDTYVSTSDYKDN--FGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNS 1372
            P      ++QA      ++  + N  +G++      + + D    +S P L        S
Sbjct: 1303 PPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALT------ES 1356

Query: 1373 DIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHG 1432
             +Q+L    T             FS S   S  G    Y   G + F GD+D RF  +  
Sbjct: 1357 LVQTLVKNRT-------------FSGSL--SHLGESSSYQGTGSVQFPGDQDLRF--ARV 1399

Query: 1433 PIAVLANSSDPSTGPE--STHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGY 1490
            P+A+      P    E  S   + A+    NYG          S   G  W  P Q   Y
Sbjct: 1400 PLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAY 1459

Query: 1491 SQGYRGHISTSTGRGRGRGLPY 1512
             + YRG        GRGRG+PY
Sbjct: 1460 GKLYRGPTRVPPRGGRGRGVPY 1481



 Score = 36.6 bits (83), Expect = 0.19
 Identities = 89/417 (21%), Positives = 148/417 (35%), Gaps = 56/417 (13%)

Query: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKE----PPSAYK-- 294
           ER    K GS  +SG  + S+   SS+S  R    SK  R ++K SK+     P A    
Sbjct: 5   ERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLG 64

Query: 295 ---EPPKAYREDKTEPKAY---------RRRRSLSPLGGRDDSPVSHRASQSLRSRKSPS 342
              +P   Y +  ++   +         RR         R D    HR  Q  RSR    
Sbjct: 65  TVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR-DLL 123

Query: 343 PAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPV 402
            A       S+ +         R S S  R  S E   D   +  + SS + SR   S  
Sbjct: 124 KAKQTEKEKSQEVSSKSGSMKDRISGSSKR--SNEETDDYGKAQVAKSSSKESR---SSK 178

Query: 403 LRRSGKSRSRSPYSSRHSRSRSRHRLS-------------RSRSRHSSISPSTLTLKSSL 449
           L +    + R   S    RS+S  +               RSRS H   S S+    S  
Sbjct: 179 LHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPS 238

Query: 450 AAELNKN---KKARAAEAARAAEAAKAAEATKAAEAAA-----KAAKASNTSTPTK-GNT 500
            A   ++     +R+  ++      K+  +T   ++ +      +A  S+T +P+     
Sbjct: 239 GASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRR 298

Query: 501 ETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKND------KAKTKPPLQVTKVENNLIV 554
           + S S          ++       SPS  G  ++       ++ ++ PL   K   +   
Sbjct: 299 QRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358

Query: 555 DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGA----KEKEQHVALVTSTL 607
             A  +      + K ++++    S+     PL  S+GA    K+KE+  A   + +
Sbjct: 359 SPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKM 415


>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
          Length = 372

 Score =  290 bits (742), Expect = 7e-78
 Identities = 151/312 (48%), Positives = 214/312 (68%), Gaps = 10/312 (3%)

Query: 702  VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
            V K++ +  IG+GT+G+V+KAR + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H
Sbjct: 16   VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75

Query: 762  QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
            ++++N+ EI   K  A  + + KG+ YLVF++ +HDL GLL + LV F  + IK  M+ L
Sbjct: 76   ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133

Query: 822  MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS-SEESRP--YTNKVITLW 878
            + GL Y H+   LHRD+K +N+L+   G +KLADFGLAR +S ++ S+P  YTN+V+TLW
Sbjct: 134  LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193

Query: 879  YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 938
            YRPPELLLGE  Y P ID+W  GCI+ E++T+ PI Q N E  QL LIS++CGS  P VW
Sbjct: 194  YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253

Query: 939  PDVIKLPYFNTMKPKKQYRRKLREE---FVFIPAAALDLFDYMLALDPSKRCTAEQALQC 995
            P+V     +  ++  K  +RK+++    +V  P  ALDL D +L LDP++R  ++ AL  
Sbjct: 254  PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP-YALDLIDKLLVLDPAQRIDSDDALNH 312

Query: 996  EFL-RDVEPSKM 1006
            +F   D  PS +
Sbjct: 313  DFFWSDPMPSDL 324


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  253 bits (646), Expect = 1e-66
 Identities = 211/769 (27%), Positives = 332/769 (43%), Gaps = 71/769 (9%)

Query: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82

Query: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
                   Q  R  K           + R+          +R      HS    GG  +  
Sbjct: 83   LAIKPPQQMSRKEKV----------HHRK--------DEKRKEKCRHHSHSAEGGKHARV 124

Query: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442
                   R+         RR  + + R   +  HSR R R RL    R R R   +    
Sbjct: 125  KEREHERRKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 183

Query: 443  LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502
               +     E    ++ +  EA R   A         ++    +  + +   P +   E 
Sbjct: 184  KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 243

Query: 503  SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562
                      K VK+ K+E     S    + + + KT    + +  E+    ++  ++  
Sbjct: 244  GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 296

Query: 563  IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622
               +E  ++   EE    +E+ +  T S   +  EQ    V+           + ED+E 
Sbjct: 297  EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 348

Query: 623  DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677
            ++    + V   +      E E+    +    P    L  GD +  SP        L  +
Sbjct: 349  ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP------ALLPIE 402

Query: 678  RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737
             + ++  P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++
Sbjct: 403  LKQEL--PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 455

Query: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
            ++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+V  Y++HD
Sbjct: 456  MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 507

Query: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
            L  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFG
Sbjct: 508  LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 567

Query: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
            LAR Y S   + YT  V+T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F  N
Sbjct: 568  LAREYGSP-LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGN 626

Query: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976
             E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   +     DL +
Sbjct: 627  SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 686

Query: 977  YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
              L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 687  KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 734



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 149 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 202

Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 203 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 247

Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 248 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 307

Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 308 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 367

Query: 408 KS 409
           +S
Sbjct: 368 ES 369



 Score = 33.1 bits (74), Expect = 2.1
 Identities = 37/166 (22%), Positives = 55/166 (33%), Gaps = 17/166 (10%)

Query: 190 RGEGSERRPRRDRRSSSGRSKERHREHRRR--------DGQRGGSEASKSRSRHSHSGEE 241
           RGE  +    +  +  S + K  HR+  +R            GG  A      H      
Sbjct: 76  RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRH 135

Query: 242 RAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDS----KAHRSRTKSSKEPPSAYKEPP 297
           R E  K+        RR+ A        SR++RD     +  R R +  +E     +E  
Sbjct: 136 REEQDKARREWERQKRREMA-----REHSRRERDRLEQLERKRERERKMREQQKEQREQK 190

Query: 298 KAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
           +  R  +   K    RR +S          S +   S  SR  P P
Sbjct: 191 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRP 236


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2
            [Homo sapiens]
          Length = 782

 Score =  252 bits (643), Expect = 2e-66
 Identities = 212/769 (27%), Positives = 333/769 (43%), Gaps = 69/769 (8%)

Query: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDS 82

Query: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
                   Q   SRK             +R  RS S    + +    +   +ER       
Sbjct: 83   LAIKPPQQM--SRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHER------- 133

Query: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442
                   R+         RR  + + R   +  HSR R R RL    R R R   +    
Sbjct: 134  -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 185

Query: 443  LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502
               +     E    ++ +  EA R   A         ++    +  + +   P +   E 
Sbjct: 186  KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 245

Query: 503  SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562
                      K VK+ K+E     S    + + + KT    + +  E+    ++  ++  
Sbjct: 246  GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 298

Query: 563  IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622
               +E  ++   EE    +E+ +  T S   +  EQ    V+           + ED+E 
Sbjct: 299  EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 350

Query: 623  DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677
            ++    + V   +      E E+    +    P    L  GD +  SP      + +  K
Sbjct: 351  ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELK 406

Query: 678  RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737
            +      P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++
Sbjct: 407  QEL----PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 457

Query: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
            ++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+V  Y++HD
Sbjct: 458  MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 509

Query: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
            L  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFG
Sbjct: 510  LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 569

Query: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
            LAR Y S   + YT  V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F   
Sbjct: 570  LAREYGSP-LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGK 628

Query: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976
             E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   +     DL +
Sbjct: 629  SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 688

Query: 977  YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
              L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 689  KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 736



 Score = 40.0 bits (92), Expect = 0.017
 Identities = 64/336 (19%), Positives = 105/336 (31%), Gaps = 34/336 (10%)

Query: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQ---RGGSEASKSRSRHSHSG 239
           S   +   GE  + R     R+S  R ++   +    D     +   + S+    H    
Sbjct: 43  SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102

Query: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKA 299
           E+R E  +  S S+ GG+            +R     + H  R +  +E   A +E  + 
Sbjct: 103 EKRKEKRRHRSHSAEGGKH-----------ARVKEKEREHERRKRHREEQDKARREWERQ 151

Query: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359
            R +     + R R  L  L  + +     R  Q  +  +             R   R  
Sbjct: 152 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 211

Query: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419
           S + R     YS                 +S W  SRSP  P   R      R P     
Sbjct: 212 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 256

Query: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474
              R        +S S  + SS   S+    S S   E  + ++      +  +E  +  
Sbjct: 257 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 316

Query: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510
           E  +  E  + + +AS  S       E S    + N
Sbjct: 317 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 352



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 151 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 204

Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 205 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 249

Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 250 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 309

Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 310 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 369

Query: 408 KS 409
           +S
Sbjct: 370 ES 371


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  249 bits (635), Expect = 2e-65
 Identities = 128/312 (41%), Positives = 186/312 (59%), Gaps = 13/312 (4%)

Query: 700  RCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQL 759
            R V +F+ +  IGEGTYG VY+ARD  T E+VALKKVR+D EK+G PI+++REI +L +L
Sbjct: 34   RSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRL 93

Query: 760  THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMR 819
             H +I+ +KE+V              + +LV  Y + DL  LLE+    F+E  +K  + 
Sbjct: 94   RHPNIVELKEVVVGNH--------LESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVL 145

Query: 820  QLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWY 879
            Q++ GL Y H+   +HRD+K SN+L+ ++G +K ADFGLAR Y     +P T KV+TLWY
Sbjct: 146  QVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPV-KPMTPKVVTLWY 204

Query: 880  RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWP 939
            R PELLLG    T +ID+W+ GCIL EL   +P+     E+ Q++LI ++ G+P   +WP
Sbjct: 205  RAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWP 264

Query: 940  DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 999
               KLP       +KQ    L+ +F ++  A L L  ++   DP KR TA   L+  + +
Sbjct: 265  GFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFK 324

Query: 1000 D----VEPSKMP 1007
            +     EP  MP
Sbjct: 325  EKPLPCEPELMP 336


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform 5
            [Homo sapiens]
          Length = 748

 Score =  248 bits (634), Expect = 2e-65
 Identities = 194/697 (27%), Positives = 307/697 (44%), Gaps = 60/697 (8%)

Query: 366  RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
            R+  Y R  S E  G+   S     P   S   +         +   + RS S    +H+
Sbjct: 29   RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHA 88

Query: 421  RSRSRHRLSRSRSRHSSISPSTLT-----LKSSLAAELNKNKKARAAEAARAAEAAKAAE 475
            R + + R    R RH               +  +A E ++ ++ R  +  R  E  +   
Sbjct: 89   RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR 148

Query: 476  ATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLK 533
              +  +   K  +        +       SA      +D   K+K  H + SP      +
Sbjct: 149  EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 208

Query: 534  NDKAKTKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKT 584
             +    + P++  K+E   ++         ++ T  A     ES S + +EE    +E+ 
Sbjct: 209  FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 268

Query: 585  KPLTPSIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV---- 634
            +  T     +E+E+       T              +  E+   D  R N +   V    
Sbjct: 269  EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 328

Query: 635  -----KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGE 689
                   E E+    +    P    L  GD +  SP      + +  K+      P+Y  
Sbjct: 329  RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLP 380

Query: 690  TKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITA 749
              +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT+
Sbjct: 381  ALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITS 435

Query: 750  IREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHF 809
            +REI  + +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F
Sbjct: 436  LREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPF 487

Query: 810  NENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRP 869
                +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + 
Sbjct: 488  LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKA 546

Query: 870  YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRI 929
            YT  V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + + 
Sbjct: 547  YTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKD 606

Query: 930  CGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCT 988
             G+P   +WP   +LP    M   +     LR+ F   +     DL +  L   P +R +
Sbjct: 607  LGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRIS 666

Query: 989  AEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
            AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 667  AEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 702



 Score = 40.0 bits (92), Expect = 0.017
 Identities = 64/336 (19%), Positives = 105/336 (31%), Gaps = 34/336 (10%)

Query: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQ---RGGSEASKSRSRHSHSG 239
           S   +   GE  + R     R+S  R ++   +    D     +   + S+    H    
Sbjct: 9   SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 68

Query: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKA 299
           E+R E  +  S S+ GG+            +R     + H  R +  +E   A +E  + 
Sbjct: 69  EKRKEKRRHRSHSAEGGKH-----------ARVKEKEREHERRKRHREEQDKARREWERQ 117

Query: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359
            R +     + R R  L  L  + +     R  Q  +  +             R   R  
Sbjct: 118 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 177

Query: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419
           S + R     YS                 +S W  SRSP  P   R      R P     
Sbjct: 178 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 222

Query: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474
              R        +S S  + SS   S+    S S   E  + ++      +  +E  +  
Sbjct: 223 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 282

Query: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510
           E  +  E  + + +AS  S       E S    + N
Sbjct: 283 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 318



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 117 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 170

Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 171 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 215

Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 216 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 275

Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 276 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 335

Query: 408 KS 409
           +S
Sbjct: 336 ES 337


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform 9
            [Homo sapiens]
          Length = 771

 Score =  248 bits (633), Expect = 3e-65
 Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)

Query: 366  RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
            R+  Y R  S E  G+   S     P   S  R+ +  +    +R  K  +R     R  
Sbjct: 63   RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 120

Query: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
              R RHR  + ++R           +  +A E ++ ++ R  +  R  E  +     +  
Sbjct: 121  ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 176

Query: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538
            +   K  +        +       SA      +D   K+K  H + SP      + +   
Sbjct: 177  QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 236

Query: 539  TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589
             + P++  K+E   ++         ++ T  A     ES S + +EE    +E+ +  T 
Sbjct: 237  GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 296

Query: 590  SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634
                +E+E+       T              +  E+   D  R N +   V         
Sbjct: 297  EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 356

Query: 635  KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694
              E E+    +    P    L  GD +  SP      + +  K+      P+Y    +  
Sbjct: 357  SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 406

Query: 695  IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754
               G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 407  ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 463

Query: 755  ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
             + +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 464  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 515

Query: 815  KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
            K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V
Sbjct: 516  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 574

Query: 875  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 575  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634

Query: 935  PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993
              +WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L
Sbjct: 635  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694

Query: 994  QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
            + E+ R+  P  + P   P W    E    KR
Sbjct: 695  KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 725



 Score = 35.4 bits (80), Expect = 0.42
 Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)

Query: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
           R+ +   R+  + +     R KE+ REH RR   R      + ++R     ++R E+A+ 
Sbjct: 93  RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 148

Query: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
            S      RR+            ++R  +  +   +  KE     +E  K  RE + E  
Sbjct: 149 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 201

Query: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
           A+ R         R+D   S +   S  SR  P P
Sbjct: 202 AHHRTM-------RED--YSDKVKASHWSRSPPRP 227



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 140 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 193

Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 194 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 238

Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 239 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 298

Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 299 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 358

Query: 408 KS 409
           +S
Sbjct: 359 ES 360



 Score = 32.3 bits (72), Expect = 3.6
 Identities = 62/336 (18%), Positives = 100/336 (29%), Gaps = 35/336 (10%)

Query: 195 ERRPRRDRRSSSGRSKERHREHRRRDGQRGGS--------EASKSRSRHSHSGEERAEVA 246
           +RR  ++ ++   R K       +RD    G             S  R   S E+R E  
Sbjct: 21  KRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEED 80

Query: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRD-------SKAHRSRTKSSKEPPSAYKEPPKA 299
            S +        +           RK++         + H  R +  +E   A +E  + 
Sbjct: 81  DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQ 140

Query: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359
            R +     + R R  L  L  + +     R  Q  +  +             R   R  
Sbjct: 141 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 200

Query: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419
           S + R     YS                 +S W  SRSP  P   R      R P     
Sbjct: 201 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 245

Query: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474
              R        +S S  + SS   S+    S S   E  + ++      +  +E  +  
Sbjct: 246 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305

Query: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510
           E  +  E  + + +AS  S       E S    + N
Sbjct: 306 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 341


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform 4
            [Homo sapiens]
          Length = 737

 Score =  248 bits (633), Expect = 3e-65
 Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)

Query: 366  RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
            R+  Y R  S E  G+   S     P   S  R+ +  +    +R  K  +R     R  
Sbjct: 29   RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 86

Query: 421  RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
              R RHR  + ++R           +  +A E ++ ++ R  +  R  E  +     +  
Sbjct: 87   ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 142

Query: 481  EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538
            +   K  +        +       SA      +D   K+K  H + SP      + +   
Sbjct: 143  QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 202

Query: 539  TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589
             + P++  K+E   ++         ++ T  A     ES S + +EE    +E+ +  T 
Sbjct: 203  GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262

Query: 590  SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634
                +E+E+       T              +  E+   D  R N +   V         
Sbjct: 263  EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 322

Query: 635  KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694
              E E+    +    P    L  GD +  SP      + +  K+      P+Y    +  
Sbjct: 323  SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 372

Query: 695  IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754
               G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 373  ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429

Query: 755  ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
             + +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 430  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481

Query: 815  KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
            K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V
Sbjct: 482  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540

Query: 875  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 541  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600

Query: 935  PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993
              +WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L
Sbjct: 601  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660

Query: 994  QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
            + E+ R+  P  + P   P W    E    KR
Sbjct: 661  KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 691



 Score = 35.4 bits (80), Expect = 0.42
 Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)

Query: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
           R+ +   R+  + +     R KE+ REH RR   R      + ++R     ++R E+A+ 
Sbjct: 59  RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 114

Query: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
            S      RR+            ++R  +  +   +  KE     +E  K  RE + E  
Sbjct: 115 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 167

Query: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
           A+ R         R+D   S +   S  SR  P P
Sbjct: 168 AHHRTM-------RED--YSDKVKASHWSRSPPRP 193



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 106 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 159

Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 160 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 204

Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 205 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 264

Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 265 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 324

Query: 408 KS 409
           +S
Sbjct: 325 ES 326


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  246 bits (628), Expect = 1e-64
 Identities = 209/769 (27%), Positives = 332/769 (43%), Gaps = 81/769 (10%)

Query: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82

Query: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
                   Q  R  K           + R+  +    +   R     +   +ER       
Sbjct: 83   LAIKPPQQMSRKEKV----------HHRKDEKRKEKWKHARV----KEREHER------- 121

Query: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442
                   R+         RR  + + R   +  HSR R R RL    R R R   +    
Sbjct: 122  -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 173

Query: 443  LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502
               +     E    ++ +  EA R   A         ++    +  + +   P +   E 
Sbjct: 174  KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 233

Query: 503  SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562
                      K VK+ K+E     S    + + + KT    + +  E+    ++  ++  
Sbjct: 234  GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 286

Query: 563  IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622
               +E  ++   EE    +E+ +  T S   +  EQ    V+           + ED+E 
Sbjct: 287  EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 338

Query: 623  DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677
            ++    + V   +      E E+    +    P    L  GD +  SP        L  +
Sbjct: 339  ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP------ALLPIE 392

Query: 678  RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737
             + ++  P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++
Sbjct: 393  LKQEL--PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 445

Query: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
            ++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+V  Y++HD
Sbjct: 446  MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 497

Query: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
            L  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFG
Sbjct: 498  LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 557

Query: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
            LAR Y S   + YT  V+T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F  N
Sbjct: 558  LAREYGSP-LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGN 616

Query: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976
             E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   +     DL +
Sbjct: 617  SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 676

Query: 977  YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
              L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 677  KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 724



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 139 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 192

Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 193 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 237

Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297

Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 357

Query: 408 KS 409
           +S
Sbjct: 358 ES 359


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform 8
            [Homo sapiens]
          Length = 780

 Score =  243 bits (621), Expect = 8e-64
 Identities = 209/777 (26%), Positives = 332/777 (42%), Gaps = 87/777 (11%)

Query: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82

Query: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
                   Q  R  K           + R+         +R+   ++R    ER       
Sbjct: 83   LAIKPPQQMSRKEKV----------HHRK-------DEKRKEKKHARVKEKER------- 118

Query: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRS----------RSR-HRLSRSRSR 434
                   R+         RR  + + R   +  HSR           R R  +L R R R
Sbjct: 119  ---EHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRER 175

Query: 435  HSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTST 494
               +       +     E    ++ +  EA R   A         ++    +  + +   
Sbjct: 176  ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 235

Query: 495  PTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIV 554
            P +   E           K VK+ K+E     S    + + + KT    + +  E+    
Sbjct: 236  PPRERFELGDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGS 288

Query: 555  DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPP 614
            ++  ++     +E  ++   EE    +E+ +  T S   +  EQ    V+          
Sbjct: 289  EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE-------- 340

Query: 615  MLPEDKEADSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKK 669
             + ED+E ++    + V   +      E E+    +    P    L  GD +  SP    
Sbjct: 341  EMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP---- 396

Query: 670  TATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGE 729
              + +  K+      P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E
Sbjct: 397  ALSPIELKQEL----PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDE 447

Query: 730  MVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYL 789
            +VALK+++++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+
Sbjct: 448  IVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYI 499

Query: 790  VFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG 849
            V  Y++HDL  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G
Sbjct: 500  VMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAG 559

Query: 850  QIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT 909
             +K+ DFGLAR Y S   + YT  V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T
Sbjct: 560  ILKVGDFGLAREYGSP-LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLT 618

Query: 910  KKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIP 968
            +KP+F    E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   + 
Sbjct: 619  QKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLS 678

Query: 969  AAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
                DL +  L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 679  DQGFDLMNKFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 734



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 38/155 (24%), Positives = 59/155 (38%), Gaps = 11/155 (7%)

Query: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
           R+ +   R+  + +     R KE+ REH RR   R      + ++R     ++R E+A+ 
Sbjct: 93  RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 148

Query: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
            S    G               RK    +  R + K  +E     KE  +   E + E +
Sbjct: 149 HSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQRE----QKERERRAEERRKERE 204

Query: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
           A RR  S      R+D   S +   S  SR  P P
Sbjct: 205 A-RREVSAHHRTMRED--YSDKVKASHWSRSPPRP 236



 Score = 32.0 bits (71), Expect = 4.7
 Identities = 50/249 (20%), Positives = 78/249 (31%), Gaps = 27/249 (10%)

Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
           +RR    E + +  R     + +E  REH RR+    G    + R        ER    +
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMR 180

Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTK---SSKEPPSAY-KEPPKAYRE- 302
                    + +   A          R+  AH    +   S K   S + + PP+  RE 
Sbjct: 181 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 240

Query: 303 ----DKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG------------ 346
               D  +P    +      L    D   S R + S  S  + S +G             
Sbjct: 241 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 300

Query: 347 -GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYS 400
            GS+                 + S S  +S +   +VS    S    R + +     P S
Sbjct: 301 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 360

Query: 401 PVLRRSGKS 409
              R SG+S
Sbjct: 361 RFDRDSGES 369


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  243 bits (619), Expect = 1e-63
 Identities = 133/305 (43%), Positives = 189/305 (61%), Gaps = 15/305 (4%)

Query: 702  VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
            +D F  +  IGEGTYG VYKA++++TG++VALKK+RLD E EG P TAIREI +L++L H
Sbjct: 1    MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 762  QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENH-IKSFMRQ 820
             +I+ + ++V ++             YLVFE++  DL   ++S        H IKS++ Q
Sbjct: 61   PNIVRLLDVVHNERK----------LYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQ 110

Query: 821  LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
            L++G+ +CH    +HRD+K  N+L+N  G IKLADFGLAR +     R YT++V+TLWYR
Sbjct: 111  LLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVP-LRTYTHEVVTLWYR 169

Query: 881  PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
             PE+LLG + YT A+D+WS GCI  E+ T+K +F  + E+ QL  I R+ G+P    WP 
Sbjct: 170  APEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPG 229

Query: 941  VIKLPYFNTMKPKKQYRRKLREEFV-FIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 999
            V +LP +    PK  + RK  EE V  +     DL   +L  DPS+R TA+ AL   +  
Sbjct: 230  VTQLPDYKGSFPK--WTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFS 287

Query: 1000 DVEPS 1004
              EPS
Sbjct: 288  SPEPS 292


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform 3
            [Homo sapiens]
          Length = 526

 Score =  242 bits (618), Expect = 2e-63
 Identities = 131/329 (39%), Positives = 191/329 (58%), Gaps = 11/329 (3%)

Query: 698  GKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILR 757
            G R V++F  +  I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI  + 
Sbjct: 162  GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221

Query: 758  QLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSF 817
            +  H +I+ ++EIV           DK   Y+V  Y++HDL  L+E+    F    +K+ 
Sbjct: 222  KAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEVKTL 273

Query: 818  MRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITL 877
            M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFGLAR Y S   + YT  V+TL
Sbjct: 274  MIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTL 332

Query: 878  WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 937
            WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P   +
Sbjct: 333  WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 392

Query: 938  WPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQALQCE 996
            WP   +LP    M   +     LR+ F   +     DL +  L   P +R +AE  L+ E
Sbjct: 393  WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHE 452

Query: 997  FLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
            + R+  P  + P   P W    E    KR
Sbjct: 453  YFRET-PLPIDPSMFPTWPAKSEQQRVKR 480


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  237 bits (604), Expect = 7e-62
 Identities = 133/313 (42%), Positives = 186/313 (59%), Gaps = 16/313 (5%)

Query: 702  VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
            ++ F  +  IGEGTYG VYKAR+K TGE+VALKK+RLD E EG P TAIREI +L++L H
Sbjct: 1    MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 762  QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFNENHIKSFMRQ 820
             +I+ + +++            +   YLVFE++  DL   ++ S L       IKS++ Q
Sbjct: 61   PNIVKLLDVI----------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110

Query: 821  LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
            L++GL +CH    LHRD+K  N+L+N  G IKLADFGLAR +     R YT++V+TLWYR
Sbjct: 111  LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYR 169

Query: 881  PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
             PE+LLG + Y+ A+D+WS GCI  E+ T++ +F  + E+ QL  I R  G+P   VWP 
Sbjct: 170  APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229

Query: 941  VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRD 1000
            V  +P +    P K  R+   +    +      L   ML  DP+KR +A+ AL   F +D
Sbjct: 230  VTSMPDYKPSFP-KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288

Query: 1001 VEPSKMPPPDLPL 1013
            V     P P L L
Sbjct: 289  V---TKPVPHLRL 298


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  232 bits (591), Expect = 2e-60
 Identities = 121/294 (41%), Positives = 183/294 (62%), Gaps = 14/294 (4%)

Query: 711  IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
            IGEGTYG VYK R K TG++VA+KK+RL++E+EG P TAIREI +L++L H +I++++++
Sbjct: 10   IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69

Query: 771  VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFNENHIKSFMRQLMEGLDYC 828
            +                YL+FE++  DL   L+S     + + + +KS++ Q+++G+ +C
Sbjct: 70   LMQDS----------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119

Query: 829  HKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE 888
            H +  LHRD+K  N+L++++G IKLADFGLAR +     R YT++V+TLWYR PE+LLG 
Sbjct: 120  HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSPEVLLGS 178

Query: 889  ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFN 948
             RY+  +D+WS G I  EL TKKP+F  + E+ QL  I R  G+P   VWP+V  L  + 
Sbjct: 179  ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238

Query: 949  TMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
               PK +    L      +    LDL   ML  DP+KR + + AL   +  D++
Sbjct: 239  NTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  232 bits (591), Expect = 2e-60
 Identities = 121/313 (38%), Positives = 188/313 (60%), Gaps = 15/313 (4%)

Query: 702  VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLT- 760
            +D++ I+G IGEG +G V+KA+  +TGE+VALKKV L   ++GFP  A+REIK L+++  
Sbjct: 1    MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60

Query: 761  HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820
            +Q ++ +K +              G F L FE+M  DL  ++        +  +KS+++ 
Sbjct: 61   NQYVVQLKAVFPHG----------GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQM 110

Query: 821  LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
            L++G+ +CH  N +HRD+K +N+L++  GQ+K+ADFGLAR++S + SR YT++V T WYR
Sbjct: 111  LLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYR 170

Query: 881  PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
             PELL G  +Y   +D+WS GCI+GEL    P+F    ++ QL  + RI G+P P VWP+
Sbjct: 171  APELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 230

Query: 941  VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL-- 998
            + +LP +N +  K+Q    L E    +   ALDL    L   P +R  A +AL  ++   
Sbjct: 231  LTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFT 290

Query: 999  --RDVEPSKMPPP 1009
                  PS++P P
Sbjct: 291  APLPAHPSELPIP 303


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  231 bits (588), Expect = 5e-60
 Identities = 121/294 (41%), Positives = 182/294 (61%), Gaps = 14/294 (4%)

Query: 711  IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
            IGEGTYG VYK R K TG++VA+KK+RL++E+EG P TAIREI +L++L H +I++++++
Sbjct: 10   IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69

Query: 771  VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFNENHIKSFMRQLMEGLDYC 828
            +                YL+FE++  DL   L+S     + + + +KS++ Q+++G+ +C
Sbjct: 70   LMQDS----------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119

Query: 829  HKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE 888
            H +  LHRD+K  N+L++++G IKLADFGLAR +     R YT++ ITLWYR PE+LLG 
Sbjct: 120  HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEAITLWYRSPEVLLGS 178

Query: 889  ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFN 948
             RY+  +D+WS G I  EL TKKP+F  + E+ QL  I R  G+P   VWP+V  L  + 
Sbjct: 179  ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238

Query: 949  TMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
               PK +    L      +    LDL   ML  DP+KR + + AL   +  D++
Sbjct: 239  NTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  223 bits (568), Expect = 1e-57
 Identities = 123/306 (40%), Positives = 188/306 (61%), Gaps = 19/306 (6%)

Query: 702  VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
            + K++ +  IGEGTYG V+KA++++T E+VALK+VRLD++ EG P +A+REI +L++L H
Sbjct: 1    MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 762  QSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820
            ++I+ + +++ +DK+             LVFE+ D DL    +S     +   +KSF+ Q
Sbjct: 61   KNIVRLHDVLHSDKK-----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ 109

Query: 821  LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
            L++GL +CH +N LHRD+K  N+L+N  G++KLADFGLAR +     R Y+ +V+TLWYR
Sbjct: 110  LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYR 168

Query: 881  PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANQELAQLELISRICGSPCPAVWP 939
            PP++L G + Y+ +ID+WS GCI  EL    +P+F  N    QL+ I R+ G+P    WP
Sbjct: 169  PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228

Query: 940  DVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF 997
             + KLP +   KP   Y     L      + A   DL   +L  +P +R +AE+ALQ  +
Sbjct: 229  SMTKLPDY---KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285

Query: 998  LRDVEP 1003
              D  P
Sbjct: 286  FSDFCP 291


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  217 bits (553), Expect = 6e-56
 Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)

Query: 652  PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702
            PP     +D++K          PE       L+S    K    R       +I +GK  +
Sbjct: 111  PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 168

Query: 703  DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
            + +  +  +GEGTY  VYK + K T  +VALK++RL++E EG P TAIRE+ +L+ L H 
Sbjct: 169  ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 227

Query: 763  SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
            +I+ + +I+  ++          +  LVFEY+D DL   L+      N +++K F+ QL+
Sbjct: 228  NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 277

Query: 823  EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
             GL YCH++  LHRD+K  N+L+N RG++KLADFGLAR   S  ++ Y+N+V+TLWYRPP
Sbjct: 278  RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 336

Query: 883  ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942
            ++LLG   Y+  ID+W  GCI  E+ T +P+F  +    QL  I RI G+P    WP ++
Sbjct: 337  DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 396

Query: 943  KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
                F T    K     L      + +   DL   +L  +   R +AE A++  F   + 
Sbjct: 397  SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 456

Query: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035
                  PD        E+  +K    +   M D
Sbjct: 457  ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 489


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  217 bits (553), Expect = 6e-56
 Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)

Query: 652  PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702
            PP     +D++K          PE       L+S    K    R       +I +GK  +
Sbjct: 105  PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 162

Query: 703  DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
            + +  +  +GEGTY  VYK + K T  +VALK++RL++E EG P TAIRE+ +L+ L H 
Sbjct: 163  ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 221

Query: 763  SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
            +I+ + +I+  ++          +  LVFEY+D DL   L+      N +++K F+ QL+
Sbjct: 222  NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 271

Query: 823  EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
             GL YCH++  LHRD+K  N+L+N RG++KLADFGLAR   S  ++ Y+N+V+TLWYRPP
Sbjct: 272  RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 330

Query: 883  ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942
            ++LLG   Y+  ID+W  GCI  E+ T +P+F  +    QL  I RI G+P    WP ++
Sbjct: 331  DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 390

Query: 943  KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
                F T    K     L      + +   DL   +L  +   R +AE A++  F   + 
Sbjct: 391  SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 450

Query: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035
                  PD        E+  +K    +   M D
Sbjct: 451  ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 483


>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
          Length = 504

 Score =  216 bits (551), Expect = 1e-55
 Identities = 130/367 (35%), Positives = 197/367 (53%), Gaps = 17/367 (4%)

Query: 636  KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDI 695
            K V ++   L  D  +   L    D+ + P+E     Q+ S   PK            DI
Sbjct: 108  KGVHRRAAALQPDFDVSKRLSLPMDI-RLPQEFLQKLQMESPDLPKPLSRMSRRASLSDI 166

Query: 696  DWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI 755
             +GK  ++ +  +  +GEGTY  V+K R K T  +VALK++RL++E EG P TAIRE+ +
Sbjct: 167  GFGK--LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSL 223

Query: 756  LRQLTHQSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
            L+ L H +I+ + +++ TD+           +  LVFEY+D DL   L+      + +++
Sbjct: 224  LKNLKHANIVTLHDLIHTDR-----------SLTLVFEYLDSDLKQYLDHCGNLMSMHNV 272

Query: 815  KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
            K FM QL+ GL YCH +  LHRD+K  N+L+N RG++KLADFGLAR   S  ++ Y+N+V
Sbjct: 273  KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARA-KSVPTKTYSNEV 331

Query: 875  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
            +TLWYRPP++LLG   Y+  ID+W  GCI  E+ T +P+F  +    +L LI R+ G+P 
Sbjct: 332  VTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPT 391

Query: 935  PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQ 994
               WP V     F T        + L      +    + L   +L  +   R +AE AL 
Sbjct: 392  EETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALS 451

Query: 995  CEFLRDV 1001
              + R +
Sbjct: 452  HSYFRSL 458


>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  215 bits (547), Expect = 3e-55
 Identities = 124/338 (36%), Positives = 186/338 (55%), Gaps = 16/338 (4%)

Query: 665  PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARD 724
            P+E     Q+ S   PK            DI +GK  ++ +  +  +GEGTY  V+K R 
Sbjct: 106  PQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGK--LETYVKLDKLGEGTYATVFKGRS 163

Query: 725  KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIV-TDKEDALDFKKD 783
            K T  +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +++ TD+         
Sbjct: 164  KLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--------- 213

Query: 784  KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 843
              +  LVFEY+D DL   L+      + +++K FM QL+ GL YCH +  LHRD+K  N+
Sbjct: 214  --SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNL 271

Query: 844  LLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI 903
            L+N RG++KLADFGLAR   S  ++ Y+N+V+TLWYRPP++LLG   Y+  ID+W  GCI
Sbjct: 272  LINERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330

Query: 904  LGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREE 963
              E+ T +P+F  +    +L LI R+ G+P    WP V     F T        + L   
Sbjct: 331  HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390

Query: 964  FVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 1001
               +    + L   +L  +   R +AE AL   + R +
Sbjct: 391  APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428


>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  215 bits (547), Expect = 3e-55
 Identities = 124/338 (36%), Positives = 186/338 (55%), Gaps = 16/338 (4%)

Query: 665  PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARD 724
            P+E     Q+ S   PK            DI +GK  ++ +  +  +GEGTY  V+K R 
Sbjct: 106  PQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGK--LETYVKLDKLGEGTYATVFKGRS 163

Query: 725  KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIV-TDKEDALDFKKD 783
            K T  +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +++ TD+         
Sbjct: 164  KLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--------- 213

Query: 784  KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 843
              +  LVFEY+D DL   L+      + +++K FM QL+ GL YCH +  LHRD+K  N+
Sbjct: 214  --SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNL 271

Query: 844  LLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI 903
            L+N RG++KLADFGLAR   S  ++ Y+N+V+TLWYRPP++LLG   Y+  ID+W  GCI
Sbjct: 272  LINERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330

Query: 904  LGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREE 963
              E+ T +P+F  +    +L LI R+ G+P    WP V     F T        + L   
Sbjct: 331  HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390

Query: 964  FVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 1001
               +    + L   +L  +   R +AE AL   + R +
Sbjct: 391  APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  214 bits (544), Expect = 7e-55
 Identities = 113/294 (38%), Positives = 175/294 (59%), Gaps = 14/294 (4%)

Query: 711  IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
            +GEGTY  VYK R K T  +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +I
Sbjct: 198  LGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDI 256

Query: 771  V-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCH 829
            V TDK           +  LVFEY+D DL   ++      + +++K F+ Q++ GL YCH
Sbjct: 257  VHTDK-----------SLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305

Query: 830  KKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEE 889
            ++  LHRD+K  N+L+N +G++KLADFGLAR   S  ++ Y+N+V+TLWYRPP++LLG  
Sbjct: 306  RRKVLHRDLKPQNLLINEKGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSS 364

Query: 890  RYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNT 949
             Y+  ID+W  GCI  E+ + +P+F  +    +L LI R+ G+P    WP +     F  
Sbjct: 365  EYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424

Query: 950  MKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEP 1003
                K   + L      + +  ++L    L  +  KR +AE+A++  + R + P
Sbjct: 425  YNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  206 bits (524), Expect = 1e-52
 Identities = 116/312 (37%), Positives = 177/312 (56%), Gaps = 17/312 (5%)

Query: 704  KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNE---KEGFPITAIREIKILRQLT 760
            +++ +  +GEG +  VYKARDK+T ++VA+KK++L +    K+G   TA+REIK+L++L+
Sbjct: 11   RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70

Query: 761  HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820
            H +II +          LD    K    LVF++M+ DL  +++   +    +HIK++M  
Sbjct: 71   HPNIIGL----------LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120

Query: 821  LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
             ++GL+Y H+   LHRD+K +N+LL+  G +KLADFGLA+ + S  +R YT++V+T WYR
Sbjct: 121  TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-NRAYTHQVVTRWYR 179

Query: 881  PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
             PELL G   Y   +D+W+ GCIL EL  + P    + +L QL  I    G+P    WPD
Sbjct: 180  APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239

Query: 941  VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRD 1000
            +  LP + T K        L   F       LDL   +   +P  R TA QAL+ ++  +
Sbjct: 240  MCSLPDYVTFKSFPGI--PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297

Query: 1001 VEPSKMPPPDLP 1012
              P   P   LP
Sbjct: 298  -RPGPTPGCQLP 308


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  204 bits (519), Expect = 5e-52
 Identities = 104/274 (37%), Positives = 157/274 (57%), Gaps = 13/274 (4%)

Query: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
            +D EK+G PI+++REI +L +L H +I+ +KE+V              + +LV  Y + D
Sbjct: 1    MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52

Query: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
            L  LLE+    F+E  +K  + Q++ GL Y H+   +HRD+K SN+L+ ++G +K ADFG
Sbjct: 53   LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112

Query: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
            LAR Y     +P T KV+TLWYR PELLLG    T +ID+W+ GCIL EL   +P+    
Sbjct: 113  LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171

Query: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977
             E+ Q++LI ++ G+P   +WP   KLP       +KQ    L+ +F ++  A L L  +
Sbjct: 172  SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231

Query: 978  MLALDPSKRCTAEQALQCEFLRD----VEPSKMP 1007
            +   DP KR TA   L+  + ++     EP  MP
Sbjct: 232  LFMYDPKKRATAGDCLESSYFKEKPLPCEPELMP 265


>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  204 bits (518), Expect = 7e-52
 Identities = 102/270 (37%), Positives = 158/270 (58%), Gaps = 10/270 (3%)

Query: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
            +D EK+G PI+++REI +L +L H +I+ +KE+V              + +LV  Y + D
Sbjct: 1    MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52

Query: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
            L  LLE+    F+E  +K  + Q++ GL Y H+   +HRD+K SN+L+ ++G +K ADFG
Sbjct: 53   LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112

Query: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
            LAR Y     +P T KV+TLWYR PELLLG    T +ID+W+ GCIL EL   +P+    
Sbjct: 113  LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171

Query: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977
             E+ Q++LI ++ G+P   +WP   KLP       +KQ    L+ +F ++  A L L  +
Sbjct: 172  SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231

Query: 978  MLALDPSKRCTAEQALQCEFLRDVEPSKMP 1007
            +   DP KR TA   L+  + ++ +P ++P
Sbjct: 232  LFMYDPKKRATAGDCLESSYFKE-KPLRLP 260


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  200 bits (508), Expect = 1e-50
 Identities = 113/304 (37%), Positives = 173/304 (56%), Gaps = 15/304 (4%)

Query: 703  DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
            D ++ +  +GEG+Y  VYK + K  G++VALK +RL  E+EG P TAIRE  +L+ L H 
Sbjct: 115  DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173

Query: 763  SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
            +I+ + +I+  KE             LVFEY+  DL   ++      + +++K F+ QL+
Sbjct: 174  NIVLLHDIIHTKE----------TLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLL 223

Query: 823  EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
             GL Y H++  LHRD+K  N+L+++ G++KLADFGLAR   S  S  Y+N+V+TLWYRPP
Sbjct: 224  RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARA-KSVPSHTYSNEVVTLWYRPP 282

Query: 883  ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA-QLELISRICGSPCPAVWPDV 941
            ++LLG   Y+  +D+W  GCI  E+      F   +++  QLE I  + G+P    WP V
Sbjct: 283  DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGV 342

Query: 942  IKLPYFNTMKPKKQYRRKLREEFVFIPAA--ALDLFDYMLALDPSKRCTAEQALQCEFLR 999
              LP+F   +      + LR+ +  +     A DL   +L   P  R +A+ AL  E+  
Sbjct: 343  HSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFS 402

Query: 1000 DVEP 1003
            D+ P
Sbjct: 403  DLPP 406


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.128    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,476,693
Number of Sequences: 37866
Number of extensions: 4022876
Number of successful extensions: 51827
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1108
Number of HSP's successfully gapped in prelim test: 1437
Number of HSP's that attempted gapping in prelim test: 26244
Number of HSP's gapped (non-prelim): 16453
length of query: 1512
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1397
effective length of database: 13,892,928
effective search space: 19408420416
effective search space used: 19408420416
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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