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Search of human proteins with 145309300
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo
sapiens]
(1452 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 2903 0.0
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 2818 0.0
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 927 0.0
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 920 0.0
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 290 7e-78
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 253 9e-67
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 252 2e-66
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 249 2e-65
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 248 2e-65
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 248 3e-65
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 248 3e-65
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 246 1e-64
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 243 7e-64
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 243 1e-63
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 242 2e-63
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 237 7e-62
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 232 2e-60
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 232 2e-60
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 231 5e-60
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 223 1e-57
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 217 6e-56
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 217 6e-56
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 216 1e-55
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 215 3e-55
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 215 3e-55
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 214 6e-55
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 206 1e-52
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens] 204 5e-52
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens] 204 7e-52
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 200 9e-51
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 2903 bits (7526), Expect = 0.0
Identities = 1452/1452 (100%), Positives = 1452/1452 (100%)
Query: 1 MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60
MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF
Sbjct: 1 MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60
Query: 61 LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120
LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV
Sbjct: 61 LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120
Query: 121 FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180
FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS
Sbjct: 121 FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180
Query: 181 PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240
PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE
Sbjct: 181 PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240
Query: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300
ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY
Sbjct: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300
Query: 301 REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360
REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS
Sbjct: 301 REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360
Query: 361 PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS
Sbjct: 361 PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
Query: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA
Sbjct: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
Query: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540
EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK
Sbjct: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540
Query: 541 PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600
PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV
Sbjct: 541 PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600
Query: 601 ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660
ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD
Sbjct: 601 ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660
Query: 661 LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720
LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY
Sbjct: 661 LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720
Query: 721 KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780
KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF
Sbjct: 721 KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780
Query: 781 KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840
KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC
Sbjct: 781 KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840
Query: 841 SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900
SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC
Sbjct: 841 SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900
Query: 901 GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960
GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL
Sbjct: 901 GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960
Query: 961 REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020
REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL
Sbjct: 961 REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020
Query: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPGE 1080
WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPGE
Sbjct: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPGE 1080
Query: 1081 KQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKD 1140
KQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKD
Sbjct: 1081 KQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKD 1140
Query: 1141 VLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQR 1200
VLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQR
Sbjct: 1141 VLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQR 1200
Query: 1201 PPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGG 1260
PPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGG
Sbjct: 1201 PPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGG 1260
Query: 1261 IDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNY 1320
IDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNY
Sbjct: 1261 IDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNY 1320
Query: 1321 STASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANS 1380
STASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANS
Sbjct: 1321 STASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANS 1380
Query: 1381 SDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHIST 1440
SDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHIST
Sbjct: 1381 SDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHIST 1440
Query: 1441 STGRGRGRGLPY 1452
STGRGRGRGLPY
Sbjct: 1441 STGRGRGRGLPY 1452
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 2818 bits (7306), Expect = 0.0
Identities = 1436/1514 (94%), Positives = 1441/1514 (95%), Gaps = 64/1514 (4%)
Query: 1 MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60
MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF
Sbjct: 1 MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLF 60
Query: 61 LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120
LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV
Sbjct: 61 LAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRV 120
Query: 121 FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180
FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS
Sbjct: 121 FSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGS 180
Query: 181 PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240
PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE
Sbjct: 181 PASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGE 240
Query: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300
ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY
Sbjct: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAY 300
Query: 301 REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360
REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS
Sbjct: 301 REDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPS 360
Query: 361 PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS
Sbjct: 361 PYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
Query: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA
Sbjct: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
Query: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540
EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK
Sbjct: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTK 540
Query: 541 PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600
PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV
Sbjct: 541 PPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHV 600
Query: 601 ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660
ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD
Sbjct: 601 ALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDD 660
Query: 661 LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720
LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY
Sbjct: 661 LSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVY 720
Query: 721 KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780
KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF
Sbjct: 721 KARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDF 780
Query: 781 KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840
KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC
Sbjct: 781 KKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKC 840
Query: 841 SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900
SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC
Sbjct: 841 SNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSC 900
Query: 901 GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960
GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL
Sbjct: 901 GCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKL 960
Query: 961 REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020
REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL
Sbjct: 961 REEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHEL 1020
Query: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPGE 1080
WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAP
Sbjct: 1021 WSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAP-- 1078
Query: 1081 KQTDP------------------------------------STPQQESSK---PLGGI-- 1099
+T P S QQ+ +K P G +
Sbjct: 1079 VKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILAT 1138
Query: 1100 -----------QPSSQT---IQP-------KVETDAAQAAVQSAFAVLLTQLIKAQQSKQ 1138
Q SS+ IQP KVETDAAQAAVQSAFAVLLTQLIKAQQSKQ
Sbjct: 1139 GEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQ 1198
Query: 1139 KDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPD 1198
KDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPD
Sbjct: 1199 KDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPD 1258
Query: 1199 QRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKRE 1258
QRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKRE
Sbjct: 1259 QRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKRE 1318
Query: 1259 GGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLD 1318
GGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLD
Sbjct: 1319 GGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLD 1378
Query: 1319 NYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLA 1378
NYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLA
Sbjct: 1379 NYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLA 1438
Query: 1379 NSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHI 1438
NSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHI
Sbjct: 1439 NSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHI 1498
Query: 1439 STSTGRGRGRGLPY 1452
STSTGRGRGRGLPY
Sbjct: 1499 STSTGRGRGRGLPY 1512
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 927 bits (2397), Expect = 0.0
Identities = 646/1525 (42%), Positives = 796/1525 (52%), Gaps = 301/1525 (19%)
Query: 134 ASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEG 193
AS G + PLVEY+D+SS S+ S + +
Sbjct: 61 ASLGTVIKPLVEYDDISSDSD---------------------------TFSDDMAFKLDR 93
Query: 194 SERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSS 253
E RR S K RH +HRR + K +S+ S + SGSS
Sbjct: 94 RENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKR 153
Query: 254 SGGRRKS-ASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYR- 311
S A + SSS++ R SK H+ +T+ +E S +K+ K++R+ +T PK+Y+
Sbjct: 154 SNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRET-PKSYKT 212
Query: 312 ----RRRSLSP------LGGRDDSPV--------------SHRASQSLRSRKSPSPAGG- 346
+RRS SP +DDSP SH +S +KSP
Sbjct: 213 VDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRR 272
Query: 347 ------------------GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYS 388
SPYSRR RS SPYSRRRS SY R SY SPSPY
Sbjct: 273 QSVSPPYKEPSAYQSSTRSPSPYSRR-QRSVSPYSRRRSSSYERSGSYSGR---SPSPYG 328
Query: 389 SSSWRRSRSPY--------SPV-LRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSIS 439
RRS SP+ SP+ R+S KSRSRSP SRHS S S+ + S SRSRHSSIS
Sbjct: 329 R---RRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSIS 385
Query: 440 PSTLTLKSSLAAELNKNKKARA--AEAAR--------------------------AAEAA 471
P L L SSL AEL++ KK RA A AA+ E+
Sbjct: 386 PVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESK 445
Query: 472 KAAEATKAAEAA--AKAAKASNTSTPTKGNTETSA----SASQTNHVKDVKK-------- 517
K + K ++A + ++ +T K +++T S+ + VKD+K
Sbjct: 446 KLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKP 505
Query: 518 --------------------------IKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENN 551
I P P++ + PP+ +
Sbjct: 506 IALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPP 565
Query: 552 LIVDKATKKAVIVGKESK---SAATKEESVSLKEKTKPLTPSIGAKEKEQHVALV----T 604
L + V S S +K +VS + ++P + K + A + T
Sbjct: 566 LPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPV-QVSVKTQVSVTAAIPHLKT 624
Query: 605 STLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGD-DLSK 663
STLPPLPLPP+LP D + DS + + K VKKE E++ R LL DLPLPPELPGGD
Sbjct: 625 STLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPD 684
Query: 664 SPEEKK-TATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKA 722
SPE K T Q K+RPKIC PRYGE ++ + DWGKRCVDKFDIIGIIGEGTYGQVYKA
Sbjct: 685 SPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKA 744
Query: 723 RDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKK 782
+DKDTGE+VALKKVRLDNEKEGFPITAIREIKILRQL H+S++NMKEIVTDK+DALDFKK
Sbjct: 745 KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKK 804
Query: 783 DKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSN 842
DKGAFYLVFEYMDHDLMGLLESGLVHF+E+HIKSFM+QLMEGL+YCHKKNFLHRDIKCSN
Sbjct: 805 DKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSN 864
Query: 843 ILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 902
ILLNN GQIKLADFGLARLY+SEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
Sbjct: 865 ILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 924
Query: 903 ILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLRE 962
ILGELFTKKPIFQAN ELAQLELISR+CGSPCPAVWPDVIKLPYFNTMKPKKQYRR+LRE
Sbjct: 925 ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLRE 984
Query: 963 EFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWS 1022
EF FIP+AALDL D+ML LDPSKRCTAEQ LQ +FL+DVE SKM PPDLP WQDCHELWS
Sbjct: 985 EFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWS 1044
Query: 1023 KKRRRQKQMG-MTDDVSTIKAPRKDLSLG-----LDDSRTNTPQ--------------GV 1062
KKRRRQ+Q G + ++ K RK+ + G + +S PQ G+
Sbjct: 1045 KKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL 1104
Query: 1063 LPSSQLKSQGSSNVAPG--EKQTDPSTPQQ----------ESSKPLGGI----------- 1099
+Q +Q V + QTD S PQ E + L +
Sbjct: 1105 ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEAT 1164
Query: 1100 --QPSSQTIQPK--------------------VETDAAQAAVQSAFAVLLTQLIKAQQSK 1137
Q S+T+ P+ +E + A +Q+ AVLL+QL+K Q+
Sbjct: 1165 SQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPA 1224
Query: 1138 QKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPP 1197
LEE + R P P + P ILPP
Sbjct: 1225 GS---LEENNSDKNSGPQGPRRTPTMPQEEAAACP-------------------PHILPP 1262
Query: 1198 DQRPPE------PPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQP 1251
++RPPE PP PPP+ E DL SS+ + + V AALLQLL+ QP
Sbjct: 1263 EKRPPEPPGPPPPPPPPPLVEGDL------------SSAPQELNPAVTAALLQLLS--QP 1308
Query: 1252 QDDPKREGGIDYQAGDTYVSTSDYKDN--FGSSSFSSAPYVSNDGLGSSSAPPLERRSFI 1309
+ +P ++QA ++ + N +G++ + + D +S P L
Sbjct: 1309 EAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALT----- 1363
Query: 1310 GNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEY 1369
S +Q+L T FS S S G Y G + F GD+D RF
Sbjct: 1364 -ESLVQTLVKNRT-------------FSGSL--SHLGESSSYQGTGSVQFPGDQDLRF-- 1405
Query: 1370 SHGPIAVLANSSDPSTGPE--STHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQG 1427
+ P+A+ P E S + A+ NYG S G W P Q
Sbjct: 1406 ARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQS 1465
Query: 1428 PGYSQGYRGHISTSTGRGRGRGLPY 1452
Y + YRG GRGRG+PY
Sbjct: 1466 SAYGKLYRGPTRVPPRGGRGRGVPY 1490
Score = 36.6 bits (83), Expect = 0.18
Identities = 89/417 (21%), Positives = 148/417 (35%), Gaps = 56/417 (13%)
Query: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKE----PPSAYK-- 294
ER K GS +SG + S+ SS+S R SK R ++K SK+ P A
Sbjct: 5 ERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLG 64
Query: 295 ---EPPKAYREDKTEPKAY---------RRRRSLSPLGGRDDSPVSHRASQSLRSRKSPS 342
+P Y + ++ + RR R D HR Q RSR
Sbjct: 65 TVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR-DLL 123
Query: 343 PAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPV 402
A S+ + R S S R S E D + + SS + SR S
Sbjct: 124 KAKQTEKEKSQEVSSKSGSMKDRISGSSKR--SNEETDDYGKAQVAKSSSKESR---SSK 178
Query: 403 LRRSGKSRSRSPYSSRHSRSRSRHRLS-------------RSRSRHSSISPSTLTLKSSL 449
L + + R S RS+S + RSRS H S S+ S
Sbjct: 179 LHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPS 238
Query: 450 AAELNKN---KKARAAEAARAAEAAKAAEATKAAEAAA-----KAAKASNTSTPTK-GNT 500
A ++ +R+ ++ K+ +T ++ + +A S+T +P+
Sbjct: 239 GASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRR 298
Query: 501 ETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKND------KAKTKPPLQVTKVENNLIV 554
+ S S ++ SPS G ++ ++ ++ PL K +
Sbjct: 299 QRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358
Query: 555 DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGA----KEKEQHVALVTSTL 607
A + + K ++++ S+ PL S+GA K+KE+ A + +
Sbjct: 359 SPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKM 415
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 920 bits (2378), Expect = 0.0
Identities = 645/1519 (42%), Positives = 796/1519 (52%), Gaps = 298/1519 (19%)
Query: 134 ASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEG 193
AS G + PLVEY+D+SS S+ S + +
Sbjct: 61 ASLGTVIKPLVEYDDISSDSD---------------------------TFSDDMAFKLDR 93
Query: 194 SERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSS 253
E RR S K RH +HRR + K +S+ S + SGSS
Sbjct: 94 RENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKR 153
Query: 254 SGGRRKS-ASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYR- 311
S A + SSS++ R SK H+ +T+ +E S +K+ K++R+ +T PK+Y+
Sbjct: 154 SNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRET-PKSYKT 212
Query: 312 ----RRRSLSP------LGGRDDSPV--------------SHRASQSLRSRKSPSPAGG- 346
+RRS SP +DDSP SH +S +KSP
Sbjct: 213 VDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRR 272
Query: 347 ------------------GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYS 388
SPYSRR RS SPYSRRRS SY R SY SPSPY
Sbjct: 273 QSVSPPYKEPSAYQSSTRSPSPYSRR-QRSVSPYSRRRSSSYERSGSYSGR---SPSPYG 328
Query: 389 SSSWRRSRSPY--------SPV-LRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSIS 439
RRS SP+ SP+ R+S KSRSRSP SRHS S S+ + S SRSRHSSIS
Sbjct: 329 R---RRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSIS 385
Query: 440 PSTLTLKSSLAAELNKNKKARA--AEAAR--------------------------AAEAA 471
P L L SSL AEL++ KK RA A AA+ E+
Sbjct: 386 PVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESK 445
Query: 472 KAAEATKAAEAA--AKAAKASNTSTPTKGNTETSA----SASQTNHVKDVKK-------- 517
K + K ++A + ++ +T K +++T S+ + VKD+K
Sbjct: 446 KLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKP 505
Query: 518 --------------------------IKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENN 551
I P P++ + PP+ +
Sbjct: 506 IALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPP 565
Query: 552 LIVDKATKKAVIVGKESK---SAATKEESVSLKEKTKPLTPSIGAKEKEQHVALV----T 604
L + V S S +K +VS + ++P + K + A + T
Sbjct: 566 LPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPV-QVSVKTQVSVTAAIPHLKT 624
Query: 605 STLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGD-DLSK 663
STLPPLPLPP+LP D + DS + + K VKKE E++ R LL DLPLPPELPGGD
Sbjct: 625 STLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPD 684
Query: 664 SPEEKK-TATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKA 722
SPE K T Q K+RPKIC PRYGE ++ + DWGKRCVDKFDIIGIIGEGTYGQVYKA
Sbjct: 685 SPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKA 744
Query: 723 RDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKK 782
+DKDTGE+VALKKVRLDNEKEGFPITAIREIKILRQL H+S++NMKEIVTDK+DALDFKK
Sbjct: 745 KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKK 804
Query: 783 DKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSN 842
DKGAFYLVFEYMDHDLMGLLESGLVHF+E+HIKSFM+QLMEGL+YCHKKNFLHRDIKCSN
Sbjct: 805 DKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSN 864
Query: 843 ILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 902
ILLNN GQIKLADFGLARLY+SEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC
Sbjct: 865 ILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 924
Query: 903 ILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLRE 962
ILGELFTKKPIFQAN ELAQLELISR+CGSPCPAVWPDVIKLPYFNTMKPKKQYRR+LRE
Sbjct: 925 ILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLRE 984
Query: 963 EFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWS 1022
EF FIP+AALDL D+ML LDPSKRCTAEQ LQ +FL+DVE SKM PPDLP WQDCHELWS
Sbjct: 985 EFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWS 1044
Query: 1023 KKRRRQKQMG-MTDDVSTIKAPRKDLSLG-----LDDSRTNTPQ--------------GV 1062
KKRRRQ+Q G + ++ K RK+ + G + +S PQ G+
Sbjct: 1045 KKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKVESGAGDAIGL 1104
Query: 1063 LPSSQLKSQGSSNVAPG--EKQTDPSTPQQ----------ESSKPLGGI----------- 1099
+Q +Q V + QTD S PQ E + L +
Sbjct: 1105 ADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEAT 1164
Query: 1100 --QPSSQTIQPK--------------------VETDAAQAAVQSAFAVLLTQLIKAQQSK 1137
Q S+T+ P+ +E + A +Q+ AVLL+QL+K Q+
Sbjct: 1165 SQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPA 1224
Query: 1138 QKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPP 1197
LE EN S + P TP Q++ + + PEP
Sbjct: 1225 GS---LE--ENNSDKNSG----PQGPRRTPTMPQEEAAEKR-------PPEP-------- 1260
Query: 1198 DQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKR 1257
PP PP PPP+ E DL SS+ + + V AALLQLL+ QP+ +P
Sbjct: 1261 -PGPPPPPPPPPLVEGDL------------SSAPQELNPAVTAALLQLLS--QPEAEPPG 1305
Query: 1258 EGGIDYQAGDTYVSTSDYKDN--FGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQ 1315
++QA ++ + N +G++ + + D +S P L S +Q
Sbjct: 1306 HLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALT------ESLVQ 1359
Query: 1316 SLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIA 1375
+L T FS S S G Y G + F GD+D RF + P+A
Sbjct: 1360 TLVKNRT-------------FSGSL--SHLGESSSYQGTGSVQFPGDQDLRF--ARVPLA 1402
Query: 1376 VLANSSDPSTGPE--STHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQG 1433
+ P E S + A+ NYG S G W P Q Y +
Sbjct: 1403 LHPVVGQPFLKAEGSSNSVVHAETKLQNYGELGPGTTGASSSGAGLHWGGPTQSSAYGKL 1462
Query: 1434 YRGHISTSTGRGRGRGLPY 1452
YRG GRGRG+PY
Sbjct: 1463 YRGPTRVPPRGGRGRGVPY 1481
Score = 36.6 bits (83), Expect = 0.18
Identities = 89/417 (21%), Positives = 148/417 (35%), Gaps = 56/417 (13%)
Query: 241 ERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKE----PPSAYK-- 294
ER K GS +SG + S+ SS+S R SK R ++K SK+ P A
Sbjct: 5 ERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLG 64
Query: 295 ---EPPKAYREDKTEPKAY---------RRRRSLSPLGGRDDSPVSHRASQSLRSRKSPS 342
+P Y + ++ + RR R D HR Q RSR
Sbjct: 65 TVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR-DLL 123
Query: 343 PAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPV 402
A S+ + R S S R S E D + + SS + SR S
Sbjct: 124 KAKQTEKEKSQEVSSKSGSMKDRISGSSKR--SNEETDDYGKAQVAKSSSKESR---SSK 178
Query: 403 LRRSGKSRSRSPYSSRHSRSRSRHRLS-------------RSRSRHSSISPSTLTLKSSL 449
L + + R S RS+S + RSRS H S S+ S
Sbjct: 179 LHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPS 238
Query: 450 AAELNKN---KKARAAEAARAAEAAKAAEATKAAEAAA-----KAAKASNTSTPTK-GNT 500
A ++ +R+ ++ K+ +T ++ + +A S+T +P+
Sbjct: 239 GASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRR 298
Query: 501 ETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKND------KAKTKPPLQVTKVENNLIV 554
+ S S ++ SPS G ++ ++ ++ PL K +
Sbjct: 299 QRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358
Query: 555 DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGA----KEKEQHVALVTSTL 607
A + + K ++++ S+ PL S+GA K+KE+ A + +
Sbjct: 359 SPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKM 415
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 290 bits (742), Expect = 7e-78
Identities = 151/312 (48%), Positives = 214/312 (68%), Gaps = 10/312 (3%)
Query: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
V K++ + IG+GT+G+V+KAR + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H
Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
Query: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
++++N+ EI K A + + KG+ YLVF++ +HDL GLL + LV F + IK M+ L
Sbjct: 76 ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133
Query: 822 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS-SEESRP--YTNKVITLW 878
+ GL Y H+ LHRD+K +N+L+ G +KLADFGLAR +S ++ S+P YTN+V+TLW
Sbjct: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193
Query: 879 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 938
YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS++CGS P VW
Sbjct: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253
Query: 939 PDVIKLPYFNTMKPKKQYRRKLREE---FVFIPAAALDLFDYMLALDPSKRCTAEQALQC 995
P+V + ++ K +RK+++ +V P ALDL D +L LDP++R ++ AL
Sbjct: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP-YALDLIDKLLVLDPAQRIDSDDALNH 312
Query: 996 EFL-RDVEPSKM 1006
+F D PS +
Sbjct: 313 DFFWSDPMPSDL 324
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 253 bits (646), Expect = 9e-67
Identities = 211/769 (27%), Positives = 332/769 (43%), Gaps = 71/769 (9%)
Query: 271 RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
RK+++ KA R K+S + S + D YRR S+ G DDS
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82
Query: 326 PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
Q R K + R+ +R HS GG +
Sbjct: 83 LAIKPPQQMSRKEKV----------HHRK--------DEKRKEKCRHHSHSAEGGKHARV 124
Query: 386 PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442
R+ RR + + R + HSR R R RL R R R +
Sbjct: 125 KEREHERRKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 183
Query: 443 LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502
+ E ++ + EA R A ++ + + + P + E
Sbjct: 184 KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 243
Query: 503 SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562
K VK+ K+E S + + + KT + + E+ ++ ++
Sbjct: 244 GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 296
Query: 563 IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622
+E ++ EE +E+ + T S + EQ V+ + ED+E
Sbjct: 297 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 348
Query: 623 DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677
++ + V + E E+ + P L GD + SP L +
Sbjct: 349 ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP------ALLPIE 402
Query: 678 RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737
+ ++ P+Y + G R V++F + I EGTYG VY+A+DK T E+VALK+++
Sbjct: 403 LKQEL--PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 455
Query: 738 LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
++ EKEGFPIT++REI + + H +I+ ++EIV DK Y+V Y++HD
Sbjct: 456 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 507
Query: 798 LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
L L+E+ F +K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFG
Sbjct: 508 LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 567
Query: 858 LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
LAR Y S + YT V+T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F N
Sbjct: 568 LAREYGSP-LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGN 626
Query: 918 QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976
E+ Q+ + + G+P +WP +LP M + LR+ F + DL +
Sbjct: 627 SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 686
Query: 977 YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
L P +R +AE L+ E+ R+ P + P P W E KR
Sbjct: 687 KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 734
Score = 33.5 bits (75), Expect = 1.5
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 149 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 202
Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 203 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 247
Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
+P + L D S R + S S + S +G GS+
Sbjct: 248 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 307
Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
+ S S +S + +VS S R + + P S R SG
Sbjct: 308 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 367
Query: 408 KS 409
+S
Sbjct: 368 ES 369
Score = 33.1 bits (74), Expect = 2.0
Identities = 37/166 (22%), Positives = 55/166 (33%), Gaps = 17/166 (10%)
Query: 190 RGEGSERRPRRDRRSSSGRSKERHREHRRR--------DGQRGGSEASKSRSRHSHSGEE 241
RGE + + + S + K HR+ +R GG A H
Sbjct: 76 RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRH 135
Query: 242 RAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDS----KAHRSRTKSSKEPPSAYKEPP 297
R E K+ RR+ A SR++RD + R R + +E +E
Sbjct: 136 REEQDKARREWERQKRREMA-----REHSRRERDRLEQLERKRERERKMREQQKEQREQK 190
Query: 298 KAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
+ R + K RR +S S + S SR P P
Sbjct: 191 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRP 236
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2
[Homo sapiens]
Length = 782
Score = 252 bits (643), Expect = 2e-66
Identities = 212/769 (27%), Positives = 333/769 (43%), Gaps = 69/769 (8%)
Query: 271 RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
RK+++ KA R K+S + S + D YRR S+ G DDS
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDS 82
Query: 326 PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
Q SRK +R RS S + + + +ER
Sbjct: 83 LAIKPPQQM--SRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHER------- 133
Query: 386 PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442
R+ RR + + R + HSR R R RL R R R +
Sbjct: 134 -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 185
Query: 443 LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502
+ E ++ + EA R A ++ + + + P + E
Sbjct: 186 KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 245
Query: 503 SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562
K VK+ K+E S + + + KT + + E+ ++ ++
Sbjct: 246 GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 298
Query: 563 IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622
+E ++ EE +E+ + T S + EQ V+ + ED+E
Sbjct: 299 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 350
Query: 623 DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677
++ + V + E E+ + P L GD + SP + + K
Sbjct: 351 ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELK 406
Query: 678 RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737
+ P+Y + G R V++F + I EGTYG VY+A+DK T E+VALK+++
Sbjct: 407 QEL----PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 457
Query: 738 LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
++ EKEGFPIT++REI + + H +I+ ++EIV DK Y+V Y++HD
Sbjct: 458 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 509
Query: 798 LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
L L+E+ F +K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFG
Sbjct: 510 LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 569
Query: 858 LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
LAR Y S + YT V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F
Sbjct: 570 LAREYGSP-LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGK 628
Query: 918 QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976
E+ Q+ + + G+P +WP +LP M + LR+ F + DL +
Sbjct: 629 SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 688
Query: 977 YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
L P +R +AE L+ E+ R+ P + P P W E KR
Sbjct: 689 KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 736
Score = 40.0 bits (92), Expect = 0.016
Identities = 64/336 (19%), Positives = 105/336 (31%), Gaps = 34/336 (10%)
Query: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQ---RGGSEASKSRSRHSHSG 239
S + GE + R R+S R ++ + D + + S+ H
Sbjct: 43 SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102
Query: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKA 299
E+R E + S S+ GG+ +R + H R + +E A +E +
Sbjct: 103 EKRKEKRRHRSHSAEGGKH-----------ARVKEKEREHERRKRHREEQDKARREWERQ 151
Query: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359
R + + R R L L + + R Q + + R R
Sbjct: 152 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 211
Query: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419
S + R YS +S W SRSP P R R P
Sbjct: 212 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 256
Query: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474
R +S S + SS S+ S S E + ++ + +E +
Sbjct: 257 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 316
Query: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510
E + E + + +AS S E S + N
Sbjct: 317 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 352
Score = 33.5 bits (75), Expect = 1.5
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 151 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 204
Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 205 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 249
Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
+P + L D S R + S S + S +G GS+
Sbjct: 250 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 309
Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
+ S S +S + +VS S R + + P S R SG
Sbjct: 310 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 369
Query: 408 KS 409
+S
Sbjct: 370 ES 371
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 249 bits (635), Expect = 2e-65
Identities = 128/312 (41%), Positives = 186/312 (59%), Gaps = 13/312 (4%)
Query: 700 RCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQL 759
R V +F+ + IGEGTYG VY+ARD T E+VALKKVR+D EK+G PI+++REI +L +L
Sbjct: 34 RSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRL 93
Query: 760 THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMR 819
H +I+ +KE+V + +LV Y + DL LLE+ F+E +K +
Sbjct: 94 RHPNIVELKEVVVGNH--------LESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVL 145
Query: 820 QLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWY 879
Q++ GL Y H+ +HRD+K SN+L+ ++G +K ADFGLAR Y +P T KV+TLWY
Sbjct: 146 QVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPV-KPMTPKVVTLWY 204
Query: 880 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWP 939
R PELLLG T +ID+W+ GCIL EL +P+ E+ Q++LI ++ G+P +WP
Sbjct: 205 RAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWP 264
Query: 940 DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 999
KLP +KQ L+ +F ++ A L L ++ DP KR TA L+ + +
Sbjct: 265 GFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFK 324
Query: 1000 D----VEPSKMP 1007
+ EP MP
Sbjct: 325 EKPLPCEPELMP 336
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform 5
[Homo sapiens]
Length = 748
Score = 248 bits (634), Expect = 2e-65
Identities = 194/697 (27%), Positives = 307/697 (44%), Gaps = 60/697 (8%)
Query: 366 RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
R+ Y R S E G+ S P S + + + RS S +H+
Sbjct: 29 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHA 88
Query: 421 RSRSRHRLSRSRSRHSSISPSTLT-----LKSSLAAELNKNKKARAAEAARAAEAAKAAE 475
R + + R R RH + +A E ++ ++ R + R E +
Sbjct: 89 RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR 148
Query: 476 ATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLK 533
+ + K + + SA +D K+K H + SP +
Sbjct: 149 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 208
Query: 534 NDKAKTKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKT 584
+ + P++ K+E ++ ++ T A ES S + +EE +E+
Sbjct: 209 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 268
Query: 585 KPLTPSIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV---- 634
+ T +E+E+ T + E+ D R N + V
Sbjct: 269 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 328
Query: 635 -----KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGE 689
E E+ + P L GD + SP + + K+ P+Y
Sbjct: 329 RFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLP 380
Query: 690 TKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITA 749
+ G R V++F + I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT+
Sbjct: 381 ALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITS 435
Query: 750 IREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHF 809
+REI + + H +I+ ++EIV DK Y+V Y++HDL L+E+ F
Sbjct: 436 LREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPF 487
Query: 810 NENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRP 869
+K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFGLAR Y S +
Sbjct: 488 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKA 546
Query: 870 YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRI 929
YT V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + +
Sbjct: 547 YTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKD 606
Query: 930 CGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCT 988
G+P +WP +LP M + LR+ F + DL + L P +R +
Sbjct: 607 LGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRIS 666
Query: 989 AEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
AE L+ E+ R+ P + P P W E KR
Sbjct: 667 AEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 702
Score = 40.0 bits (92), Expect = 0.016
Identities = 64/336 (19%), Positives = 105/336 (31%), Gaps = 34/336 (10%)
Query: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQ---RGGSEASKSRSRHSHSG 239
S + GE + R R+S R ++ + D + + S+ H
Sbjct: 9 SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 68
Query: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKA 299
E+R E + S S+ GG+ +R + H R + +E A +E +
Sbjct: 69 EKRKEKRRHRSHSAEGGKH-----------ARVKEKEREHERRKRHREEQDKARREWERQ 117
Query: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359
R + + R R L L + + R Q + + R R
Sbjct: 118 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 177
Query: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419
S + R YS +S W SRSP P R R P
Sbjct: 178 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 222
Query: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474
R +S S + SS S+ S S E + ++ + +E +
Sbjct: 223 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 282
Query: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510
E + E + + +AS S E S + N
Sbjct: 283 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 318
Score = 33.5 bits (75), Expect = 1.5
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 117 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 170
Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 171 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 215
Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
+P + L D S R + S S + S +G GS+
Sbjct: 216 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 275
Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
+ S S +S + +VS S R + + P S R SG
Sbjct: 276 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 335
Query: 408 KS 409
+S
Sbjct: 336 ES 337
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform 9
[Homo sapiens]
Length = 771
Score = 248 bits (633), Expect = 3e-65
Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)
Query: 366 RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
R+ Y R S E G+ S P S R+ + + +R K +R R
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 120
Query: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
R RHR + ++R + +A E ++ ++ R + R E + +
Sbjct: 121 ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 176
Query: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538
+ K + + SA +D K+K H + SP + +
Sbjct: 177 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 236
Query: 539 TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589
+ P++ K+E ++ ++ T A ES S + +EE +E+ + T
Sbjct: 237 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 296
Query: 590 SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634
+E+E+ T + E+ D R N + V
Sbjct: 297 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 356
Query: 635 KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694
E E+ + P L GD + SP + + K+ P+Y +
Sbjct: 357 SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 406
Query: 695 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754
G R V++F + I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI
Sbjct: 407 ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 463
Query: 755 ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
+ + H +I+ ++EIV DK Y+V Y++HDL L+E+ F +
Sbjct: 464 TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 515
Query: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFGLAR Y S + YT V
Sbjct: 516 KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 574
Query: 875 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + + G+P
Sbjct: 575 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 634
Query: 935 PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993
+WP +LP M + LR+ F + DL + L P +R +AE L
Sbjct: 635 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 694
Query: 994 QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
+ E+ R+ P + P P W E KR
Sbjct: 695 KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 725
Score = 35.4 bits (80), Expect = 0.40
Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)
Query: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
R+ + R+ + + R KE+ REH RR R + ++R ++R E+A+
Sbjct: 93 RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 148
Query: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
S RR+ ++R + + + KE +E K RE + E
Sbjct: 149 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 201
Query: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
A+ R R+D S + S SR P P
Sbjct: 202 AHHRTM-------RED--YSDKVKASHWSRSPPRP 227
Score = 33.5 bits (75), Expect = 1.5
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 140 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 193
Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 194 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 238
Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
+P + L D S R + S S + S +G GS+
Sbjct: 239 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 298
Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
+ S S +S + +VS S R + + P S R SG
Sbjct: 299 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 358
Query: 408 KS 409
+S
Sbjct: 359 ES 360
Score = 32.3 bits (72), Expect = 3.4
Identities = 62/336 (18%), Positives = 100/336 (29%), Gaps = 35/336 (10%)
Query: 195 ERRPRRDRRSSSGRSKERHREHRRRDGQRGGS--------EASKSRSRHSHSGEERAEVA 246
+RR ++ ++ R K +RD G S R S E+R E
Sbjct: 21 KRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEED 80
Query: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRD-------SKAHRSRTKSSKEPPSAYKEPPKA 299
S + + RK++ + H R + +E A +E +
Sbjct: 81 DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQ 140
Query: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359
R + + R R L L + + R Q + + R R
Sbjct: 141 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 200
Query: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419
S + R YS +S W SRSP P R R P
Sbjct: 201 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 245
Query: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474
R +S S + SS S+ S S E + ++ + +E +
Sbjct: 246 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305
Query: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510
E + E + + +AS S E S + N
Sbjct: 306 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 341
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform 4
[Homo sapiens]
Length = 737
Score = 248 bits (633), Expect = 3e-65
Identities = 195/692 (28%), Positives = 309/692 (44%), Gaps = 61/692 (8%)
Query: 366 RSPSYSRHSSYERGGDVSPS-----PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHS 420
R+ Y R S E G+ S P S R+ + + +R K +R R
Sbjct: 29 RNSPYRREDSMEDRGEEDDSLAIKPPQQMS--RKEKVHHRKDEKRKEKKHARVKEKEREH 86
Query: 421 RSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAA 480
R RHR + ++R + +A E ++ ++ R + R E + +
Sbjct: 87 ERRKRHREEQDKARREWERQK----RREMAREHSRRERDRLEQLERKRERERKMREQQKE 142
Query: 481 EAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVK-KIKIEH-APSPSSGGTLKNDKAK 538
+ K + + SA +D K+K H + SP + +
Sbjct: 143 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 202
Query: 539 TKPPLQVTKVENNLIV---------DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTP 589
+ P++ K+E ++ ++ T A ES S + +EE +E+ + T
Sbjct: 203 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262
Query: 590 SIGAKEKEQHVALVTST------LPPLPLPPMLPEDKEADSLRGNISVKAV--------- 634
+E+E+ T + E+ D R N + V
Sbjct: 263 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRD 322
Query: 635 KKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKD 694
E E+ + P L GD + SP + + K+ P+Y +
Sbjct: 323 SGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELKQEL----PKYLPALQ-- 372
Query: 695 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 754
G R V++F + I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI
Sbjct: 373 ---GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 429
Query: 755 ILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
+ + H +I+ ++EIV DK Y+V Y++HDL L+E+ F +
Sbjct: 430 TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 481
Query: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFGLAR Y S + YT V
Sbjct: 482 KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 540
Query: 875 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + + G+P
Sbjct: 541 VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 600
Query: 935 PAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQAL 993
+WP +LP M + LR+ F + DL + L P +R +AE L
Sbjct: 601 EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 660
Query: 994 QCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
+ E+ R+ P + P P W E KR
Sbjct: 661 KHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 691
Score = 35.4 bits (80), Expect = 0.40
Identities = 36/155 (23%), Positives = 60/155 (38%), Gaps = 20/155 (12%)
Query: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
R+ + R+ + + R KE+ REH RR R + ++R ++R E+A+
Sbjct: 59 RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 114
Query: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
S RR+ ++R + + + KE +E K RE + E
Sbjct: 115 HS------RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE-REARREVS 167
Query: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
A+ R R+D S + S SR P P
Sbjct: 168 AHHRTM-------RED--YSDKVKASHWSRSPPRP 193
Score = 33.5 bits (75), Expect = 1.5
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 106 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 159
Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 160 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 204
Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
+P + L D S R + S S + S +G GS+
Sbjct: 205 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 264
Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
+ S S +S + +VS S R + + P S R SG
Sbjct: 265 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 324
Query: 408 KS 409
+S
Sbjct: 325 ES 326
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 246 bits (628), Expect = 1e-64
Identities = 209/769 (27%), Positives = 332/769 (43%), Gaps = 81/769 (10%)
Query: 271 RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
RK+++ KA R K+S + S + D YRR S+ G DDS
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82
Query: 326 PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
Q R K + R+ + + R + +ER
Sbjct: 83 LAIKPPQQMSRKEKV----------HHRKDEKRKEKWKHARV----KEREHER------- 121
Query: 386 PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442
R+ RR + + R + HSR R R RL R R R +
Sbjct: 122 -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 173
Query: 443 LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502
+ E ++ + EA R A ++ + + + P + E
Sbjct: 174 KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 233
Query: 503 SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562
K VK+ K+E S + + + KT + + E+ ++ ++
Sbjct: 234 GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 286
Query: 563 IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622
+E ++ EE +E+ + T S + EQ V+ + ED+E
Sbjct: 287 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 338
Query: 623 DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677
++ + V + E E+ + P L GD + SP L +
Sbjct: 339 ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP------ALLPIE 392
Query: 678 RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737
+ ++ P+Y + G R V++F + I EGTYG VY+A+DK T E+VALK+++
Sbjct: 393 LKQEL--PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 445
Query: 738 LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
++ EKEGFPIT++REI + + H +I+ ++EIV DK Y+V Y++HD
Sbjct: 446 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 497
Query: 798 LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
L L+E+ F +K+ M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFG
Sbjct: 498 LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 557
Query: 858 LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
LAR Y S + YT V+T WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F N
Sbjct: 558 LAREYGSP-LKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGN 616
Query: 918 QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976
E+ Q+ + + G+P +WP +LP M + LR+ F + DL +
Sbjct: 617 SEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 676
Query: 977 YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
L P +R +AE L+ E+ R+ P + P P W E KR
Sbjct: 677 KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 724
Score = 33.5 bits (75), Expect = 1.5
Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)
Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
Q+R E + RR+R ++R RE + R+ Q+ E + + R + E R E
Sbjct: 139 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 192
Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305
R ++ + R+D K S S+ PP PP+ E D
Sbjct: 193 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 237
Query: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352
+P + L D S R + S S + S +G GS+
Sbjct: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297
Query: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407
+ S S +S + +VS S R + + P S R SG
Sbjct: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 357
Query: 408 KS 409
+S
Sbjct: 358 ES 359
Score = 30.8 bits (68), Expect = 9.9
Identities = 39/172 (22%), Positives = 63/172 (36%), Gaps = 22/172 (12%)
Query: 190 RGEGSERRPRRDRRSSSGRSKERHR-EHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
RGE + + + S + K HR + +R++ + + R EE+ + +
Sbjct: 76 RGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARRE 135
Query: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDK-TEP 307
R+K S +DR + R R + K +E K RE K E
Sbjct: 136 WE------RQKRREMAREHSRRERDRLEQLERKRERERK-----MREQQKEQREQKERER 184
Query: 308 KAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359
+A RR+ R + HR + S K +S +SR PR P
Sbjct: 185 RAEERRKERE---ARREVSAHHRTMREDYSDKVK------ASHWSRSPPRPP 227
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform 8
[Homo sapiens]
Length = 780
Score = 243 bits (621), Expect = 7e-64
Identities = 209/777 (26%), Positives = 332/777 (42%), Gaps = 87/777 (11%)
Query: 271 RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325
RK+++ KA R K+S + S + D YRR S+ G DDS
Sbjct: 23 RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDS 82
Query: 326 PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385
Q R K + R+ +R+ ++R ER
Sbjct: 83 LAIKPPQQMSRKEKV----------HHRK-------DEKRKEKKHARVKEKER------- 118
Query: 386 PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRS----------RSR-HRLSRSRSR 434
R+ RR + + R + HSR R R +L R R R
Sbjct: 119 ---EHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRER 175
Query: 435 HSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTST 494
+ + E ++ + EA R A ++ + + +
Sbjct: 176 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 495 PTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIV 554
P + E K VK+ K+E S + + + KT + + E+
Sbjct: 236 PPRERFELGDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGS 288
Query: 555 DKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPP 614
++ ++ +E ++ EE +E+ + T S + EQ V+
Sbjct: 289 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE-------- 340
Query: 615 MLPEDKEADSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKK 669
+ ED+E ++ + V + E E+ + P L GD + SP
Sbjct: 341 EMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP---- 396
Query: 670 TATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGE 729
+ + K+ P+Y + G R V++F + I EGTYG VY+A+DK T E
Sbjct: 397 ALSPIELKQEL----PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDE 447
Query: 730 MVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYL 789
+VALK+++++ EKEGFPIT++REI + + H +I+ ++EIV DK Y+
Sbjct: 448 IVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYI 499
Query: 790 VFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRG 849
V Y++HDL L+E+ F +K+ M QL+ G+ + H LHRD+K SN+LL++ G
Sbjct: 500 VMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAG 559
Query: 850 QIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT 909
+K+ DFGLAR Y S + YT V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T
Sbjct: 560 ILKVGDFGLAREYGSP-LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLT 618
Query: 910 KKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIP 968
+KP+F E+ Q+ + + G+P +WP +LP M + LR+ F +
Sbjct: 619 QKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLS 678
Query: 969 AAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
DL + L P +R +AE L+ E+ R+ P + P P W E KR
Sbjct: 679 DQGFDLMNKFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 734
Score = 37.0 bits (84), Expect = 0.14
Identities = 38/155 (24%), Positives = 59/155 (38%), Gaps = 11/155 (7%)
Query: 189 RRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKS 248
R+ + R+ + + R KE+ REH RR R + ++R ++R E+A+
Sbjct: 93 RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR----EEQDKARREWERQKRREMARE 148
Query: 249 GSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPK 308
S G RK + R + K +E KE + E + E +
Sbjct: 149 HSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQRE----QKERERRAEERRKERE 204
Query: 309 AYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSP 343
A RR S R+D S + S SR P P
Sbjct: 205 A-RREVSAHHRTMRED--YSDKVKASHWSRSPPRP 236
Score = 32.0 bits (71), Expect = 4.5
Identities = 50/249 (20%), Positives = 78/249 (31%), Gaps = 27/249 (10%)
Query: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247
+RR E + + R + +E REH RR+ G + R ER +
Sbjct: 121 ERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMR 180
Query: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTK---SSKEPPSAY-KEPPKAYRE- 302
+ + A R+ AH + S K S + + PP+ RE
Sbjct: 181 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRER 240
Query: 303 ----DKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG------------ 346
D +P + L D S R + S S + S +G
Sbjct: 241 FELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE 300
Query: 347 -GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYS 400
GS+ + S S +S + +VS S R + + P S
Sbjct: 301 EGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPES 360
Query: 401 PVLRRSGKS 409
R SG+S
Sbjct: 361 RFDRDSGES 369
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 243 bits (619), Expect = 1e-63
Identities = 133/305 (43%), Positives = 189/305 (61%), Gaps = 15/305 (4%)
Query: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
+D F + IGEGTYG VYKA++++TG++VALKK+RLD E EG P TAIREI +L++L H
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENH-IKSFMRQ 820
+I+ + ++V ++ YLVFE++ DL ++S H IKS++ Q
Sbjct: 61 PNIVRLLDVVHNERK----------LYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQ 110
Query: 821 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
L++G+ +CH +HRD+K N+L+N G IKLADFGLAR + R YT++V+TLWYR
Sbjct: 111 LLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVP-LRTYTHEVVTLWYR 169
Query: 881 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
PE+LLG + YT A+D+WS GCI E+ T+K +F + E+ QL I R+ G+P WP
Sbjct: 170 APEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPG 229
Query: 941 VIKLPYFNTMKPKKQYRRKLREEFV-FIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 999
V +LP + PK + RK EE V + DL +L DPS+R TA+ AL +
Sbjct: 230 VTQLPDYKGSFPK--WTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFS 287
Query: 1000 DVEPS 1004
EPS
Sbjct: 288 SPEPS 292
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform 3
[Homo sapiens]
Length = 526
Score = 242 bits (618), Expect = 2e-63
Identities = 131/329 (39%), Positives = 191/329 (58%), Gaps = 11/329 (3%)
Query: 698 GKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILR 757
G R V++F + I EGTYG VY+A+DK T E+VALK+++++ EKEGFPIT++REI +
Sbjct: 162 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221
Query: 758 QLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSF 817
+ H +I+ ++EIV DK Y+V Y++HDL L+E+ F +K+
Sbjct: 222 KAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEVKTL 273
Query: 818 MRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITL 877
M QL+ G+ + H LHRD+K SN+LL++ G +K+ DFGLAR Y S + YT V+TL
Sbjct: 274 MIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTL 332
Query: 878 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 937
WYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F E+ Q+ + + G+P +
Sbjct: 333 WYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKI 392
Query: 938 WPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFDYMLALDPSKRCTAEQALQCE 996
WP +LP M + LR+ F + DL + L P +R +AE L+ E
Sbjct: 393 WPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHE 452
Query: 997 FLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025
+ R+ P + P P W E KR
Sbjct: 453 YFRET-PLPIDPSMFPTWPAKSEQQRVKR 480
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 237 bits (604), Expect = 7e-62
Identities = 133/313 (42%), Positives = 186/313 (59%), Gaps = 16/313 (5%)
Query: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
++ F + IGEGTYG VYKAR+K TGE+VALKK+RLD E EG P TAIREI +L++L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFNENHIKSFMRQ 820
+I+ + +++ + YLVFE++ DL ++ S L IKS++ Q
Sbjct: 61 PNIVKLLDVI----------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110
Query: 821 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
L++GL +CH LHRD+K N+L+N G IKLADFGLAR + R YT++V+TLWYR
Sbjct: 111 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYR 169
Query: 881 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
PE+LLG + Y+ A+D+WS GCI E+ T++ +F + E+ QL I R G+P VWP
Sbjct: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
Query: 941 VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRD 1000
V +P + P K R+ + + L ML DP+KR +A+ AL F +D
Sbjct: 230 VTSMPDYKPSFP-KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 288
Query: 1001 VEPSKMPPPDLPL 1013
V P P L L
Sbjct: 289 V---TKPVPHLRL 298
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 232 bits (591), Expect = 2e-60
Identities = 121/294 (41%), Positives = 183/294 (62%), Gaps = 14/294 (4%)
Query: 711 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
IGEGTYG VYK R K TG++VA+KK+RL++E+EG P TAIREI +L++L H +I++++++
Sbjct: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69
Query: 771 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFNENHIKSFMRQLMEGLDYC 828
+ YL+FE++ DL L+S + + + +KS++ Q+++G+ +C
Sbjct: 70 LMQDS----------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119
Query: 829 HKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE 888
H + LHRD+K N+L++++G IKLADFGLAR + R YT++V+TLWYR PE+LLG
Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSPEVLLGS 178
Query: 889 ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFN 948
RY+ +D+WS G I EL TKKP+F + E+ QL I R G+P VWP+V L +
Sbjct: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238
Query: 949 TMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
PK + L + LDL ML DP+KR + + AL + D++
Sbjct: 239 NTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 232 bits (591), Expect = 2e-60
Identities = 121/313 (38%), Positives = 188/313 (60%), Gaps = 15/313 (4%)
Query: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLT- 760
+D++ I+G IGEG +G V+KA+ +TGE+VALKKV L ++GFP A+REIK L+++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 761 HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820
+Q ++ +K + G F L FE+M DL ++ + +KS+++
Sbjct: 61 NQYVVQLKAVFPHG----------GGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQM 110
Query: 821 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
L++G+ +CH N +HRD+K +N+L++ GQ+K+ADFGLAR++S + SR YT++V T WYR
Sbjct: 111 LLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYR 170
Query: 881 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
PELL G +Y +D+WS GCI+GEL P+F ++ QL + RI G+P P VWP+
Sbjct: 171 APELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPE 230
Query: 941 VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL-- 998
+ +LP +N + K+Q L E + ALDL L P +R A +AL ++
Sbjct: 231 LTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFT 290
Query: 999 --RDVEPSKMPPP 1009
PS++P P
Sbjct: 291 APLPAHPSELPIP 303
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 231 bits (588), Expect = 5e-60
Identities = 121/294 (41%), Positives = 182/294 (61%), Gaps = 14/294 (4%)
Query: 711 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
IGEGTYG VYK R K TG++VA+KK+RL++E+EG P TAIREI +L++L H +I++++++
Sbjct: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69
Query: 771 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFNENHIKSFMRQLMEGLDYC 828
+ YL+FE++ DL L+S + + + +KS++ Q+++G+ +C
Sbjct: 70 LMQDS----------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119
Query: 829 HKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE 888
H + LHRD+K N+L++++G IKLADFGLAR + R YT++ ITLWYR PE+LLG
Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEAITLWYRSPEVLLGS 178
Query: 889 ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFN 948
RY+ +D+WS G I EL TKKP+F + E+ QL I R G+P VWP+V L +
Sbjct: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238
Query: 949 TMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
PK + L + LDL ML DP+KR + + AL + D++
Sbjct: 239 NTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 223 bits (568), Expect = 1e-57
Identities = 123/306 (40%), Positives = 188/306 (61%), Gaps = 19/306 (6%)
Query: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
+ K++ + IGEGTYG V+KA++++T E+VALK+VRLD++ EG P +A+REI +L++L H
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 762 QSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820
++I+ + +++ +DK+ LVFE+ D DL +S + +KSF+ Q
Sbjct: 61 KNIVRLHDVLHSDKK-----------LTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQ 109
Query: 821 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
L++GL +CH +N LHRD+K N+L+N G++KLADFGLAR + R Y+ +V+TLWYR
Sbjct: 110 LLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-PVRCYSAEVVTLWYR 168
Query: 881 PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANQELAQLELISRICGSPCPAVWP 939
PP++L G + Y+ +ID+WS GCI EL +P+F N QL+ I R+ G+P WP
Sbjct: 169 PPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWP 228
Query: 940 DVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEF 997
+ KLP + KP Y L + A DL +L +P +R +AE+ALQ +
Sbjct: 229 SMTKLPDY---KPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285
Query: 998 LRDVEP 1003
D P
Sbjct: 286 FSDFCP 291
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 217 bits (553), Expect = 6e-56
Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)
Query: 652 PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702
PP +D++K PE L+S K R +I +GK +
Sbjct: 111 PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 168
Query: 703 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
+ + + +GEGTY VYK + K T +VALK++RL++E EG P TAIRE+ +L+ L H
Sbjct: 169 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 227
Query: 763 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
+I+ + +I+ ++ + LVFEY+D DL L+ N +++K F+ QL+
Sbjct: 228 NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 277
Query: 823 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
GL YCH++ LHRD+K N+L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP
Sbjct: 278 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 336
Query: 883 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942
++LLG Y+ ID+W GCI E+ T +P+F + QL I RI G+P WP ++
Sbjct: 337 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 396
Query: 943 KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
F T K L + + DL +L + R +AE A++ F +
Sbjct: 397 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 456
Query: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035
PD E+ +K + M D
Sbjct: 457 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 489
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 217 bits (553), Expect = 6e-56
Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)
Query: 652 PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702
PP +D++K PE L+S K R +I +GK +
Sbjct: 105 PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 162
Query: 703 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
+ + + +GEGTY VYK + K T +VALK++RL++E EG P TAIRE+ +L+ L H
Sbjct: 163 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 221
Query: 763 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
+I+ + +I+ ++ + LVFEY+D DL L+ N +++K F+ QL+
Sbjct: 222 NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 271
Query: 823 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
GL YCH++ LHRD+K N+L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP
Sbjct: 272 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 330
Query: 883 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942
++LLG Y+ ID+W GCI E+ T +P+F + QL I RI G+P WP ++
Sbjct: 331 DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 390
Query: 943 KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002
F T K L + + DL +L + R +AE A++ F +
Sbjct: 391 SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 450
Query: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035
PD E+ +K + M D
Sbjct: 451 ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 483
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 216 bits (551), Expect = 1e-55
Identities = 130/367 (35%), Positives = 197/367 (53%), Gaps = 17/367 (4%)
Query: 636 KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDI 695
K V ++ L D + L D+ + P+E Q+ S PK DI
Sbjct: 108 KGVHRRAAALQPDFDVSKRLSLPMDI-RLPQEFLQKLQMESPDLPKPLSRMSRRASLSDI 166
Query: 696 DWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI 755
+GK ++ + + +GEGTY V+K R K T +VALK++RL++E EG P TAIRE+ +
Sbjct: 167 GFGK--LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSL 223
Query: 756 LRQLTHQSIINMKEIV-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHI 814
L+ L H +I+ + +++ TD+ + LVFEY+D DL L+ + +++
Sbjct: 224 LKNLKHANIVTLHDLIHTDR-----------SLTLVFEYLDSDLKQYLDHCGNLMSMHNV 272
Query: 815 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 874
K FM QL+ GL YCH + LHRD+K N+L+N RG++KLADFGLAR S ++ Y+N+V
Sbjct: 273 KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARA-KSVPTKTYSNEV 331
Query: 875 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 934
+TLWYRPP++LLG Y+ ID+W GCI E+ T +P+F + +L LI R+ G+P
Sbjct: 332 VTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPT 391
Query: 935 PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQ 994
WP V F T + L + + L +L + R +AE AL
Sbjct: 392 EETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALS 451
Query: 995 CEFLRDV 1001
+ R +
Sbjct: 452 HSYFRSL 458
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 215 bits (547), Expect = 3e-55
Identities = 124/338 (36%), Positives = 186/338 (55%), Gaps = 16/338 (4%)
Query: 665 PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARD 724
P+E Q+ S PK DI +GK ++ + + +GEGTY V+K R
Sbjct: 106 PQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGK--LETYVKLDKLGEGTYATVFKGRS 163
Query: 725 KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIV-TDKEDALDFKKD 783
K T +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +++ TD+
Sbjct: 164 KLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--------- 213
Query: 784 KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 843
+ LVFEY+D DL L+ + +++K FM QL+ GL YCH + LHRD+K N+
Sbjct: 214 --SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNL 271
Query: 844 LLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI 903
L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI
Sbjct: 272 LINERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330
Query: 904 LGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREE 963
E+ T +P+F + +L LI R+ G+P WP V F T + L
Sbjct: 331 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390
Query: 964 FVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 1001
+ + L +L + R +AE AL + R +
Sbjct: 391 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 215 bits (547), Expect = 3e-55
Identities = 124/338 (36%), Positives = 186/338 (55%), Gaps = 16/338 (4%)
Query: 665 PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARD 724
P+E Q+ S PK DI +GK ++ + + +GEGTY V+K R
Sbjct: 106 PQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGK--LETYVKLDKLGEGTYATVFKGRS 163
Query: 725 KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIV-TDKEDALDFKKD 783
K T +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +++ TD+
Sbjct: 164 KLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--------- 213
Query: 784 KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 843
+ LVFEY+D DL L+ + +++K FM QL+ GL YCH + LHRD+K N+
Sbjct: 214 --SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNL 271
Query: 844 LLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI 903
L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI
Sbjct: 272 LINERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330
Query: 904 LGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREE 963
E+ T +P+F + +L LI R+ G+P WP V F T + L
Sbjct: 331 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390
Query: 964 FVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 1001
+ + L +L + R +AE AL + R +
Sbjct: 391 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 214 bits (544), Expect = 6e-55
Identities = 113/294 (38%), Positives = 175/294 (59%), Gaps = 14/294 (4%)
Query: 711 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
+GEGTY VYK R K T +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +I
Sbjct: 198 LGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDI 256
Query: 771 V-TDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCH 829
V TDK + LVFEY+D DL ++ + +++K F+ Q++ GL YCH
Sbjct: 257 VHTDK-----------SLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
Query: 830 KKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEE 889
++ LHRD+K N+L+N +G++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG
Sbjct: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSS 364
Query: 890 RYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNT 949
Y+ ID+W GCI E+ + +P+F + +L LI R+ G+P WP + F
Sbjct: 365 EYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424
Query: 950 MKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEP 1003
K + L + + ++L L + KR +AE+A++ + R + P
Sbjct: 425 YNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGP 478
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 206 bits (524), Expect = 1e-52
Identities = 116/312 (37%), Positives = 177/312 (56%), Gaps = 17/312 (5%)
Query: 704 KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNE---KEGFPITAIREIKILRQLT 760
+++ + +GEG + VYKARDK+T ++VA+KK++L + K+G TA+REIK+L++L+
Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70
Query: 761 HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQ 820
H +II + LD K LVF++M+ DL +++ + +HIK++M
Sbjct: 71 HPNIIGL----------LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120
Query: 821 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 880
++GL+Y H+ LHRD+K +N+LL+ G +KLADFGLA+ + S +R YT++V+T WYR
Sbjct: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-NRAYTHQVVTRWYR 179
Query: 881 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPD 940
PELL G Y +D+W+ GCIL EL + P + +L QL I G+P WPD
Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239
Query: 941 VIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRD 1000
+ LP + T K L F LDL + +P R TA QAL+ ++ +
Sbjct: 240 MCSLPDYVTFKSFPGI--PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297
Query: 1001 VEPSKMPPPDLP 1012
P P LP
Sbjct: 298 -RPGPTPGCQLP 308
>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
Length = 289
Score = 204 bits (519), Expect = 5e-52
Identities = 104/274 (37%), Positives = 157/274 (57%), Gaps = 13/274 (4%)
Query: 738 LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
+D EK+G PI+++REI +L +L H +I+ +KE+V + +LV Y + D
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
Query: 798 LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
L LLE+ F+E +K + Q++ GL Y H+ +HRD+K SN+L+ ++G +K ADFG
Sbjct: 53 LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
Query: 858 LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
LAR Y +P T KV+TLWYR PELLLG T +ID+W+ GCIL EL +P+
Sbjct: 113 LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
Query: 918 QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977
E+ Q++LI ++ G+P +WP KLP +KQ L+ +F ++ A L L +
Sbjct: 172 SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
Query: 978 MLALDPSKRCTAEQALQCEFLRD----VEPSKMP 1007
+ DP KR TA L+ + ++ EP MP
Sbjct: 232 LFMYDPKKRATAGDCLESSYFKEKPLPCEPELMP 265
>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
Length = 272
Score = 204 bits (518), Expect = 7e-52
Identities = 102/270 (37%), Positives = 158/270 (58%), Gaps = 10/270 (3%)
Query: 738 LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797
+D EK+G PI+++REI +L +L H +I+ +KE+V + +LV Y + D
Sbjct: 1 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNH--------LESIFLVMGYCEQD 52
Query: 798 LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857
L LLE+ F+E +K + Q++ GL Y H+ +HRD+K SN+L+ ++G +K ADFG
Sbjct: 53 LASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFG 112
Query: 858 LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917
LAR Y +P T KV+TLWYR PELLLG T +ID+W+ GCIL EL +P+
Sbjct: 113 LARAYGVPV-KPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGT 171
Query: 918 QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDY 977
E+ Q++LI ++ G+P +WP KLP +KQ L+ +F ++ A L L +
Sbjct: 172 SEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHF 231
Query: 978 MLALDPSKRCTAEQALQCEFLRDVEPSKMP 1007
+ DP KR TA L+ + ++ +P ++P
Sbjct: 232 LFMYDPKKRATAGDCLESSYFKE-KPLRLP 260
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 200 bits (508), Expect = 9e-51
Identities = 113/304 (37%), Positives = 173/304 (56%), Gaps = 15/304 (4%)
Query: 703 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762
D ++ + +GEG+Y VYK + K G++VALK +RL E+EG P TAIRE +L+ L H
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQ-EEEGTPFTAIREASLLKGLKHA 173
Query: 763 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822
+I+ + +I+ KE LVFEY+ DL ++ + +++K F+ QL+
Sbjct: 174 NIVLLHDIIHTKE----------TLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLL 223
Query: 823 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882
GL Y H++ LHRD+K N+L+++ G++KLADFGLAR S S Y+N+V+TLWYRPP
Sbjct: 224 RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARA-KSVPSHTYSNEVVTLWYRPP 282
Query: 883 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA-QLELISRICGSPCPAVWPDV 941
++LLG Y+ +D+W GCI E+ F +++ QLE I + G+P WP V
Sbjct: 283 DVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGV 342
Query: 942 IKLPYFNTMKPKKQYRRKLREEFVFIPAA--ALDLFDYMLALDPSKRCTAEQALQCEFLR 999
LP+F + + LR+ + + A DL +L P R +A+ AL E+
Sbjct: 343 HSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFS 402
Query: 1000 DVEP 1003
D+ P
Sbjct: 403 DLPP 406
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,637,659
Number of Sequences: 37866
Number of extensions: 3962449
Number of successful extensions: 52040
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1170
Number of HSP's successfully gapped in prelim test: 1551
Number of HSP's that attempted gapping in prelim test: 25447
Number of HSP's gapped (non-prelim): 17353
length of query: 1452
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1337
effective length of database: 13,892,928
effective search space: 18574844736
effective search space used: 18574844736
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.