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Search of human proteins with 145199237
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|145199237 transcription elongation factor B polypeptide 3
binding protein 1 [Homo sapiens]
(1221 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|145199237 transcription elongation factor B polypeptide 3 bin... 2467 0.0
gi|239743602 PREDICTED: hypothetical protein XP_002342903 [Homo ... 691 0.0
gi|239743600 PREDICTED: hypothetical protein XP_002342902 [Homo ... 691 0.0
gi|239743598 PREDICTED: hypothetical protein XP_002342901 [Homo ... 691 0.0
gi|239743596 PREDICTED: hypothetical protein XP_002342900 [Homo ... 691 0.0
gi|239743594 PREDICTED: hypothetical protein XP_002342913, parti... 691 0.0
gi|126273519 exonuclease GOR [Homo sapiens] 691 0.0
gi|222136615 exonuclease NEF-sp isoform 2 [Homo sapiens] 110 1e-23
gi|222136613 exonuclease NEF-sp isoform 1 [Homo sapiens] 110 1e-23
gi|163965366 nascent polypeptide-associated complex alpha subuni... 80 2e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 75 5e-13
gi|194239666 interferon stimulated exonuclease gene 20kDa-like 1... 75 5e-13
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 74 8e-13
gi|6857800 interferon stimulated exonuclease [Homo sapiens] 72 4e-12
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 70 9e-12
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 70 9e-12
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 69 3e-11
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 69 4e-11
gi|13569960 interferon stimulated exonuclease gene 20kDa-like 2 ... 68 6e-11
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 67 8e-11
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 67 8e-11
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 67 8e-11
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 66 2e-10
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 65 4e-10
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 65 4e-10
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 65 5e-10
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 63 1e-09
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 62 3e-09
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 62 3e-09
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 61 6e-09
>gi|145199237 transcription elongation factor B polypeptide 3 binding
protein 1 [Homo sapiens]
Length = 1221
Score = 2467 bits (6393), Expect = 0.0
Identities = 1221/1221 (100%), Positives = 1221/1221 (100%)
Query: 1 MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGDGGEAPPAAGLGYDPYN 60
MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGDGGEAPPAAGLGYDPYN
Sbjct: 1 MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGDGGEAPPAAGLGYDPYN 60
Query: 61 PELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTREHR 120
PELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTREHR
Sbjct: 61 PELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTREHR 120
Query: 121 SAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKY 180
SAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKY
Sbjct: 121 SAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKY 180
Query: 181 SLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNY 240
SLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNY
Sbjct: 181 SLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNY 240
Query: 241 SARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNE 300
SARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNE
Sbjct: 241 SARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNE 300
Query: 301 PTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPA 360
PTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPA
Sbjct: 301 PTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPA 360
Query: 361 QVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQA 420
QVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQA
Sbjct: 361 QVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQA 420
Query: 421 SSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLP 480
SSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLP
Sbjct: 421 SSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLP 480
Query: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWP 540
DRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWP
Sbjct: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWP 540
Query: 541 SALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYS 600
SALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYS
Sbjct: 541 SALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYS 600
Query: 601 ALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQK 660
ALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQK
Sbjct: 601 ALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQK 660
Query: 661 RRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSP 720
RRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSP
Sbjct: 661 RRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSP 720
Query: 721 SVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMAS 780
SVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMAS
Sbjct: 721 SVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMAS 780
Query: 781 KTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAI 840
KTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAI
Sbjct: 781 KTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAI 840
Query: 841 EKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGR 900
EKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGR
Sbjct: 841 EKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGR 900
Query: 901 LAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTA 960
LAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTA
Sbjct: 901 LAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTA 960
Query: 961 EEKRPKDSSCRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAA 1020
EEKRPKDSSCRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAA
Sbjct: 961 EEKRPKDSSCRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAA 1020
Query: 1021 AGSVGCQVAKQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVT 1080
AGSVGCQVAKQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVT
Sbjct: 1021 AGSVGCQVAKQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVT 1080
Query: 1081 VVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1140
VVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI
Sbjct: 1081 VVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILI 1140
Query: 1141 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSE 1200
GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSE
Sbjct: 1141 GHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSE 1200
Query: 1201 DAGACMHLVIWKVREDAKTKR 1221
DAGACMHLVIWKVREDAKTKR
Sbjct: 1201 DAGACMHLVIWKVREDAKTKR 1221
>gi|239743602 PREDICTED: hypothetical protein XP_002342903 [Homo
sapiens]
Length = 675
Score = 691 bits (1784), Expect = 0.0
Identities = 360/549 (65%), Positives = 408/549 (74%), Gaps = 43/549 (7%)
Query: 672 EVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKR 731
+ EP RGPAVPPA P E CY AQR SA L A RL E+ V ISAP +++
Sbjct: 152 QAEPQNRGPAVPPAWPKMVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRK 208
Query: 732 RIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRI 791
IAH +P L T AKRT AS SQ S G + G Q KTR SGMA KTT T KRI
Sbjct: 209 TIAHSSSPCLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTATTSSKRI 268
Query: 792 AHSPSLQSL--KKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKV 849
SL SL KKPII + G +VPTV+R+ YL LF EECLKFC S QEA EKALNEEKV
Sbjct: 269 VRRASLPSLSLKKPIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKV 328
Query: 850 AYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSL 909
AYD SP+KN YLNV +NTLK+L+GL PS++PGLS+
Sbjct: 329 AYDCSPNKNRYLNVVLNTLKRLKGLTPSSMPGLSR------------------------- 363
Query: 910 SRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSS 969
AALYSRL+E+LLTQDQLKENGYPFPHPERPGGA++FT + K P DSS
Sbjct: 364 -------------AALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTGQGKGPGDSS 410
Query: 970 CRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVA 1029
CR CCRCGTEYLVSSSGRC+RD+ CYYHWGR+R ++VAGG +QY CC+AA GSVGCQVA
Sbjct: 411 CRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGGRVSQYTCCAAAPGSVGCQVA 470
Query: 1030 KQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVV 1089
KQHV+DGRKE L+GFV+TF+KELS D +PGIYALDCEM YTT+GLELTRVTVVD D+ VV
Sbjct: 471 KQHVRDGRKESLDGFVETFKKELSRDAYPGIYALDCEMCYTTHGLELTRVTVVDADMRVV 530
Query: 1090 YDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLL 1149
YDTFVKPDNEIVDYNTRFSGVTEAD+A TS+TL VQA+LLS FSA TILIGHSLESDLL
Sbjct: 531 YDTFVKPDNEIVDYNTRFSGVTEADVAKTSITLPQVQAILLSFFSAQTILIGHSLESDLL 590
Query: 1150 ALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLV 1209
ALK+IHSTVVDT+VLFPH LG PYKRSLRNL ADYL QIIQD+ DGH+SSEDA AC+ LV
Sbjct: 591 ALKLIHSTVVDTAVLFPHYLGFPYKRSLRNLAADYLAQIIQDSQDGHNSSEDANACLQLV 650
Query: 1210 IWKVREDAK 1218
+WKVR+ A+
Sbjct: 651 MWKVRQRAQ 659
Score = 36.2 bits (82), Expect = 0.20
Identities = 54/253 (21%), Positives = 88/253 (34%), Gaps = 44/253 (17%)
Query: 434 KKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAA---GRGPPRPLQLPDRKSTKAPSG 490
KK A P A+ G PA P + A G P ++ + + +AP
Sbjct: 64 KKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPPGYPEAKKVAEEAALEAPEF 123
Query: 491 KLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDS 550
L + + P++ K+A + D+ ++E + GP VP WP +
Sbjct: 124 PLPSHQPA---QSFGLWVPQMHKQASAFVDI---QAEPQNRGPAVPPAWPKMV------- 170
Query: 551 DSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDS 610
S FP +G RL A+P + PS G + K + S
Sbjct: 171 ----TESCYFPAQRGSACRLPAAPRLTERPS------------GVRISAPRKRKTIAHSS 214
Query: 611 DPMEECL-------RIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRI 663
P CL + ++S + ++ RQP K G++ TT KR +
Sbjct: 215 SP---CLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTR--NRSGMACKTTATTSSKRIV 269
Query: 664 SHLSKQGQEVEPP 676
S ++ P
Sbjct: 270 RRASLPSLSLKKP 282
>gi|239743600 PREDICTED: hypothetical protein XP_002342902 [Homo
sapiens]
Length = 675
Score = 691 bits (1784), Expect = 0.0
Identities = 360/549 (65%), Positives = 408/549 (74%), Gaps = 43/549 (7%)
Query: 672 EVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKR 731
+ EP RGPAVPPA P E CY AQR SA L A RL E+ V ISAP +++
Sbjct: 152 QAEPQNRGPAVPPAWPKMVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRK 208
Query: 732 RIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRI 791
IAH +P L T AKRT AS SQ S G + G Q KTR SGMA KTT T KRI
Sbjct: 209 TIAHSSSPCLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTATTSSKRI 268
Query: 792 AHSPSLQSL--KKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKV 849
SL SL KKPII + G +VPTV+R+ YL LF EECLKFC S QEA EKALNEEKV
Sbjct: 269 VRRASLPSLSLKKPIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKV 328
Query: 850 AYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSL 909
AYD SP+KN YLNV +NTLK+L+GL PS++PGLS+
Sbjct: 329 AYDCSPNKNRYLNVVLNTLKRLKGLTPSSMPGLSR------------------------- 363
Query: 910 SRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSS 969
AALYSRL+E+LLTQDQLKENGYPFPHPERPGGA++FT + K P DSS
Sbjct: 364 -------------AALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTGQGKGPGDSS 410
Query: 970 CRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVA 1029
CR CCRCGTEYLVSSSGRC+RD+ CYYHWGR+R ++VAGG +QY CC+AA GSVGCQVA
Sbjct: 411 CRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGGRVSQYTCCAAAPGSVGCQVA 470
Query: 1030 KQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVV 1089
KQHV+DGRKE L+GFV+TF+KELS D +PGIYALDCEM YTT+GLELTRVTVVD D+ VV
Sbjct: 471 KQHVRDGRKESLDGFVETFKKELSRDAYPGIYALDCEMCYTTHGLELTRVTVVDADMRVV 530
Query: 1090 YDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLL 1149
YDTFVKPDNEIVDYNTRFSGVTEAD+A TS+TL VQA+LLS FSA TILIGHSLESDLL
Sbjct: 531 YDTFVKPDNEIVDYNTRFSGVTEADVAKTSITLPQVQAILLSFFSAQTILIGHSLESDLL 590
Query: 1150 ALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLV 1209
ALK+IHSTVVDT+VLFPH LG PYKRSLRNL ADYL QIIQD+ DGH+SSEDA AC+ LV
Sbjct: 591 ALKLIHSTVVDTAVLFPHYLGFPYKRSLRNLAADYLAQIIQDSQDGHNSSEDANACLQLV 650
Query: 1210 IWKVREDAK 1218
+WKVR+ A+
Sbjct: 651 MWKVRQRAQ 659
Score = 36.2 bits (82), Expect = 0.20
Identities = 54/253 (21%), Positives = 88/253 (34%), Gaps = 44/253 (17%)
Query: 434 KKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAA---GRGPPRPLQLPDRKSTKAPSG 490
KK A P A+ G PA P + A G P ++ + + +AP
Sbjct: 64 KKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPPGYPEAKKVAEEAALEAPEF 123
Query: 491 KLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDS 550
L + + P++ K+A + D+ ++E + GP VP WP +
Sbjct: 124 PLPSHQPA---QSFGLWVPQMHKQASAFVDI---QAEPQNRGPAVPPAWPKMV------- 170
Query: 551 DSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDS 610
S FP +G RL A+P + PS G + K + S
Sbjct: 171 ----TESCYFPAQRGSACRLPAAPRLTERPS------------GVRISAPRKRKTIAHSS 214
Query: 611 DPMEECL-------RIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRI 663
P CL + ++S + ++ RQP K G++ TT KR +
Sbjct: 215 SP---CLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTR--NRSGMACKTTATTSSKRIV 269
Query: 664 SHLSKQGQEVEPP 676
S ++ P
Sbjct: 270 RRASLPSLSLKKP 282
>gi|239743598 PREDICTED: hypothetical protein XP_002342901 [Homo
sapiens]
Length = 675
Score = 691 bits (1784), Expect = 0.0
Identities = 360/549 (65%), Positives = 408/549 (74%), Gaps = 43/549 (7%)
Query: 672 EVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKR 731
+ EP RGPAVPPA P E CY AQR SA L A RL E+ V ISAP +++
Sbjct: 152 QAEPQNRGPAVPPAWPKMVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRK 208
Query: 732 RIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRI 791
IAH +P L T AKRT AS SQ S G + G Q KTR SGMA KTT T KRI
Sbjct: 209 TIAHSSSPCLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTATTSSKRI 268
Query: 792 AHSPSLQSL--KKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKV 849
SL SL KKPII + G +VPTV+R+ YL LF EECLKFC S QEA EKALNEEKV
Sbjct: 269 VRRASLPSLSLKKPIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKV 328
Query: 850 AYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSL 909
AYD SP+KN YLNV +NTLK+L+GL PS++PGLS+
Sbjct: 329 AYDCSPNKNRYLNVVLNTLKRLKGLTPSSMPGLSR------------------------- 363
Query: 910 SRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSS 969
AALYSRL+E+LLTQDQLKENGYPFPHPERPGGA++FT + K P DSS
Sbjct: 364 -------------AALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTGQGKGPGDSS 410
Query: 970 CRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVA 1029
CR CCRCGTEYLVSSSGRC+RD+ CYYHWGR+R ++VAGG +QY CC+AA GSVGCQVA
Sbjct: 411 CRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGGRVSQYTCCAAAPGSVGCQVA 470
Query: 1030 KQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVV 1089
KQHV+DGRKE L+GFV+TF+KELS D +PGIYALDCEM YTT+GLELTRVTVVD D+ VV
Sbjct: 471 KQHVRDGRKESLDGFVETFKKELSRDAYPGIYALDCEMCYTTHGLELTRVTVVDADMRVV 530
Query: 1090 YDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLL 1149
YDTFVKPDNEIVDYNTRFSGVTEAD+A TS+TL VQA+LLS FSA TILIGHSLESDLL
Sbjct: 531 YDTFVKPDNEIVDYNTRFSGVTEADVAKTSITLPQVQAILLSFFSAQTILIGHSLESDLL 590
Query: 1150 ALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLV 1209
ALK+IHSTVVDT+VLFPH LG PYKRSLRNL ADYL QIIQD+ DGH+SSEDA AC+ LV
Sbjct: 591 ALKLIHSTVVDTAVLFPHYLGFPYKRSLRNLAADYLAQIIQDSQDGHNSSEDANACLQLV 650
Query: 1210 IWKVREDAK 1218
+WKVR+ A+
Sbjct: 651 MWKVRQRAQ 659
Score = 36.2 bits (82), Expect = 0.20
Identities = 54/253 (21%), Positives = 88/253 (34%), Gaps = 44/253 (17%)
Query: 434 KKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAA---GRGPPRPLQLPDRKSTKAPSG 490
KK A P A+ G PA P + A G P ++ + + +AP
Sbjct: 64 KKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPPGYPEAKKVAEEAALEAPEF 123
Query: 491 KLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDS 550
L + + P++ K+A + D+ ++E + GP VP WP +
Sbjct: 124 PLPSHQPA---QSFGLWVPQMHKQASAFVDI---QAEPQNRGPAVPPAWPKMV------- 170
Query: 551 DSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDS 610
S FP +G RL A+P + PS G + K + S
Sbjct: 171 ----TESCYFPAQRGSACRLPAAPRLTERPS------------GVRISAPRKRKTIAHSS 214
Query: 611 DPMEECL-------RIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRI 663
P CL + ++S + ++ RQP K G++ TT KR +
Sbjct: 215 SP---CLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTR--NRSGMACKTTATTSSKRIV 269
Query: 664 SHLSKQGQEVEPP 676
S ++ P
Sbjct: 270 RRASLPSLSLKKP 282
>gi|239743596 PREDICTED: hypothetical protein XP_002342900 [Homo
sapiens]
Length = 675
Score = 691 bits (1784), Expect = 0.0
Identities = 360/549 (65%), Positives = 408/549 (74%), Gaps = 43/549 (7%)
Query: 672 EVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKR 731
+ EP RGPAVPPA P E CY AQR SA L A RL E+ V ISAP +++
Sbjct: 152 QAEPQNRGPAVPPAWPKMVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRK 208
Query: 732 RIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRI 791
IAH +P L T AKRT AS SQ S G + G Q KTR SGMA KTT T KRI
Sbjct: 209 TIAHSSSPCLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTATTSSKRI 268
Query: 792 AHSPSLQSL--KKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKV 849
SL SL KKPII + G +VPTV+R+ YL LF EECLKFC S QEA EKALNEEKV
Sbjct: 269 VRRASLPSLSLKKPIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKV 328
Query: 850 AYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSL 909
AYD SP+KN YLNV +NTLK+L+GL PS++PGLS+
Sbjct: 329 AYDCSPNKNRYLNVVLNTLKRLKGLTPSSMPGLSR------------------------- 363
Query: 910 SRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSS 969
AALYSRL+E+LLTQDQLKENGYPFPHPERPGGA++FT + K P DSS
Sbjct: 364 -------------AALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTGQGKGPGDSS 410
Query: 970 CRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVA 1029
CR CCRCGTEYLVSSSGRC+RD+ CYYHWGR+R ++VAGG +QY CC+AA GSVGCQVA
Sbjct: 411 CRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGGRVSQYTCCAAAPGSVGCQVA 470
Query: 1030 KQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVV 1089
KQHV+DGRKE L+GFV+TF+KELS D +PGIYALDCEM YTT+GLELTRVTVVD D+ VV
Sbjct: 471 KQHVRDGRKESLDGFVETFKKELSRDAYPGIYALDCEMCYTTHGLELTRVTVVDADMRVV 530
Query: 1090 YDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLL 1149
YDTFVKPDNEIVDYNTRFSGVTEAD+A TS+TL VQA+LLS FSA TILIGHSLESDLL
Sbjct: 531 YDTFVKPDNEIVDYNTRFSGVTEADVAKTSITLPQVQAILLSFFSAQTILIGHSLESDLL 590
Query: 1150 ALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLV 1209
ALK+IHSTVVDT+VLFPH LG PYKRSLRNL ADYL QIIQD+ DGH+SSEDA AC+ LV
Sbjct: 591 ALKLIHSTVVDTAVLFPHYLGFPYKRSLRNLAADYLAQIIQDSQDGHNSSEDANACLQLV 650
Query: 1210 IWKVREDAK 1218
+WKVR+ A+
Sbjct: 651 MWKVRQRAQ 659
Score = 36.2 bits (82), Expect = 0.20
Identities = 54/253 (21%), Positives = 88/253 (34%), Gaps = 44/253 (17%)
Query: 434 KKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAA---GRGPPRPLQLPDRKSTKAPSG 490
KK A P A+ G PA P + A G P ++ + + +AP
Sbjct: 64 KKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPPGYPEAKKVAEEAALEAPEF 123
Query: 491 KLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDS 550
L + + P++ K+A + D+ ++E + GP VP WP +
Sbjct: 124 PLPSHQPA---QSFGLWVPQMHKQASAFVDI---QAEPQNRGPAVPPAWPKMV------- 170
Query: 551 DSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDS 610
S FP +G RL A+P + PS G + K + S
Sbjct: 171 ----TESCYFPAQRGSACRLPAAPRLTERPS------------GVRISAPRKRKTIAHSS 214
Query: 611 DPMEECL-------RIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRI 663
P CL + ++S + ++ RQP K G++ TT KR +
Sbjct: 215 SP---CLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTR--NRSGMACKTTATTSSKRIV 269
Query: 664 SHLSKQGQEVEPP 676
S ++ P
Sbjct: 270 RRASLPSLSLKKP 282
>gi|239743594 PREDICTED: hypothetical protein XP_002342913, partial
[Homo sapiens]
Length = 552
Score = 691 bits (1784), Expect = 0.0
Identities = 360/549 (65%), Positives = 408/549 (74%), Gaps = 43/549 (7%)
Query: 672 EVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKR 731
+ EP RGPAVPPA P E CY AQR SA L A RL E+ V ISAP +++
Sbjct: 29 QAEPQNRGPAVPPAWPKMVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRK 85
Query: 732 RIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRI 791
IAH +P L T AKRT AS SQ S G + G Q KTR SGMA KTT T KRI
Sbjct: 86 TIAHSSSPCLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTATTSSKRI 145
Query: 792 AHSPSLQSL--KKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKV 849
SL SL KKPII + G +VPTV+R+ YL LF EECLKFC S QEA EKALNEEKV
Sbjct: 146 VRRASLPSLSLKKPIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKV 205
Query: 850 AYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSL 909
AYD SP+KN YLNV +NTLK+L+GL PS++PGLS+
Sbjct: 206 AYDCSPNKNRYLNVVLNTLKRLKGLTPSSMPGLSR------------------------- 240
Query: 910 SRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSS 969
AALYSRL+E+LLTQDQLKENGYPFPHPERPGGA++FT + K P DSS
Sbjct: 241 -------------AALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTGQGKGPGDSS 287
Query: 970 CRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVA 1029
CR CCRCGTEYLVSSSGRC+RD+ CYYHWGR+R ++VAGG +QY CC+AA GSVGCQVA
Sbjct: 288 CRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGGRVSQYTCCAAAPGSVGCQVA 347
Query: 1030 KQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVV 1089
KQHV+DGRKE L+GFV+TF+KELS D +PGIYALDCEM YTT+GLELTRVTVVD D+ VV
Sbjct: 348 KQHVRDGRKESLDGFVETFKKELSRDAYPGIYALDCEMCYTTHGLELTRVTVVDADMRVV 407
Query: 1090 YDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLL 1149
YDTFVKPDNEIVDYNTRFSGVTEAD+A TS+TL VQA+LLS FSA TILIGHSLESDLL
Sbjct: 408 YDTFVKPDNEIVDYNTRFSGVTEADVAKTSITLPQVQAILLSFFSAQTILIGHSLESDLL 467
Query: 1150 ALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLV 1209
ALK+IHSTVVDT+VLFPH LG PYKRSLRNL ADYL QIIQD+ DGH+SSEDA AC+ LV
Sbjct: 468 ALKLIHSTVVDTAVLFPHYLGFPYKRSLRNLAADYLAQIIQDSQDGHNSSEDANACLQLV 527
Query: 1210 IWKVREDAK 1218
+WKVR+ A+
Sbjct: 528 MWKVRQRAQ 536
Score = 33.9 bits (76), Expect = 0.97
Identities = 39/175 (22%), Positives = 64/175 (36%), Gaps = 38/175 (21%)
Query: 509 PKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPK 568
P++ K+A + D+ ++E + GP VP WP + S FP +G
Sbjct: 16 PQMHKQASAFVDI---QAEPQNRGPAVPPAWPKMV-----------TESCYFPAQRGSAC 61
Query: 569 RLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECL-------RIFN 621
RL A+P + PS G + K + S P CL +
Sbjct: 62 RLPAAPRLTERPS------------GVRISAPRKRKTIAHSSSP---CLVTGYTDAKRTR 106
Query: 622 ESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPP 676
++S + ++ RQP K G++ TT KR + S ++ P
Sbjct: 107 VASSSQRSRGSKVGRQPGKTR--NRSGMACKTTATTSSKRIVRRASLPSLSLKKP 159
>gi|126273519 exonuclease GOR [Homo sapiens]
Length = 675
Score = 691 bits (1784), Expect = 0.0
Identities = 360/549 (65%), Positives = 408/549 (74%), Gaps = 43/549 (7%)
Query: 672 EVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKR 731
+ EP RGPAVPPA P E CY AQR SA L A RL E+ V ISAP +++
Sbjct: 152 QAEPQNRGPAVPPAWPKMVTESCYF---PAQRGSACRLPAAPRLTERPSGVRISAPRKRK 208
Query: 732 RIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRI 791
IAH +P L T AKRT AS SQ S G + G Q KTR SGMA KTT T KRI
Sbjct: 209 TIAHSSSPCLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTRNRSGMACKTTATTSSKRI 268
Query: 792 AHSPSLQSL--KKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKV 849
SL SL KKPII + G +VPTV+R+ YL LF EECLKFC S QEA EKALNEEKV
Sbjct: 269 VRRASLPSLSLKKPIILRSSGCQVPTVLRRGYLQLFTEECLKFCASKQEAEEKALNEEKV 328
Query: 850 AYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSL 909
AYD SP+KN YLNV +NTLK+L+GL PS++PGLS+
Sbjct: 329 AYDCSPNKNRYLNVVLNTLKRLKGLTPSSMPGLSR------------------------- 363
Query: 910 SRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSS 969
AALYSRL+E+LLTQDQLKENGYPFPHPERPGGA++FT + K P DSS
Sbjct: 364 -------------AALYSRLQEFLLTQDQLKENGYPFPHPERPGGAVLFTGQGKGPGDSS 410
Query: 970 CRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVA 1029
CR CCRCGTEYLVSSSGRC+RD+ CYYHWGR+R ++VAGG +QY CC+AA GSVGCQVA
Sbjct: 411 CRVCCRCGTEYLVSSSGRCVRDQLCYYHWGRVRSSQVAGGRVSQYTCCAAAPGSVGCQVA 470
Query: 1030 KQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVV 1089
KQHV+DGRKE L+GFV+TF+KELS D +PGIYALDCEM YTT+GLELTRVTVVD D+ VV
Sbjct: 471 KQHVRDGRKESLDGFVETFKKELSRDAYPGIYALDCEMCYTTHGLELTRVTVVDADMRVV 530
Query: 1090 YDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLL 1149
YDTFVKPDNEIVDYNTRFSGVTEAD+A TS+TL VQA+LLS FSA TILIGHSLESDLL
Sbjct: 531 YDTFVKPDNEIVDYNTRFSGVTEADVAKTSITLPQVQAILLSFFSAQTILIGHSLESDLL 590
Query: 1150 ALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLV 1209
ALK+IHSTVVDT+VLFPH LG PYKRSLRNL ADYL QIIQD+ DGH+SSEDA AC+ LV
Sbjct: 591 ALKLIHSTVVDTAVLFPHYLGFPYKRSLRNLAADYLAQIIQDSQDGHNSSEDASACLQLV 650
Query: 1210 IWKVREDAK 1218
+WKVR+ A+
Sbjct: 651 MWKVRQRAQ 659
Score = 36.2 bits (82), Expect = 0.20
Identities = 54/253 (21%), Positives = 88/253 (34%), Gaps = 44/253 (17%)
Query: 434 KKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAA---GRGPPRPLQLPDRKSTKAPSG 490
KK A P A+ G PA P + A G P ++ + + +AP
Sbjct: 64 KKVAKEAAPEASRHLGAEQSPAGAPEGSKMLRATAPCWFPPGYPEAKKVAEEAALEAPEF 123
Query: 491 KLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDS 550
L + + P++ K+A + D+ ++E + GP VP WP +
Sbjct: 124 PLPSHQPA---QSFGLWVPQMHKQASAFVDI---QAEPQNRGPAVPPAWPKMV------- 170
Query: 551 DSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDS 610
S FP +G RL A+P + PS G + K + S
Sbjct: 171 ----TESCYFPAQRGSACRLPAAPRLTERPS------------GVRISAPRKRKTIAHSS 214
Query: 611 DPMEECL-------RIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRI 663
P CL + ++S + ++ RQP K G++ TT KR +
Sbjct: 215 SP---CLVTGYTDAKRTRVASSSQRSRGSKVGRQPGKTR--NRSGMACKTTATTSSKRIV 269
Query: 664 SHLSKQGQEVEPP 676
S ++ P
Sbjct: 270 RRASLPSLSLKKP 282
>gi|222136615 exonuclease NEF-sp isoform 2 [Homo sapiens]
Length = 743
Score = 110 bits (274), Expect = 1e-23
Identities = 70/179 (39%), Positives = 103/179 (57%), Gaps = 6/179 (3%)
Query: 1042 EGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIV 1101
E F+ T D P ++ LDCEM T+ G ELTR+++V V D VKP+N+I+
Sbjct: 211 ENFLLTKCNGSIADNSP-LFGLDCEMCLTSKGRELTRISLVAEGGCCVMDELVKPENKIL 269
Query: 1102 DYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHSTVVDT 1161
DY T FSG+T+ L + L+DVQ L ++ D +L+GHSL+ DL ALK+IH V+DT
Sbjct: 270 DYLTSFSGITKKILNPVTTKLKDVQRQLKALLPPDAVLVGHSLDLDLRALKMIHPYVIDT 329
Query: 1162 SVLFPHRLGLPYKRSLRNLMADYLRQIIQ--DNVDGHSSSEDAGACMHLVIWKVREDAK 1218
S+L+ G +K L+ L L + IQ D + GH ++EDA + L + ++ K
Sbjct: 330 SLLYVREQGRRFK--LKFLAKVILGKDIQCPDRL-GHDATEDARTILELARYFLKHGPK 385
>gi|222136613 exonuclease NEF-sp isoform 1 [Homo sapiens]
Length = 774
Score = 110 bits (274), Expect = 1e-23
Identities = 70/179 (39%), Positives = 103/179 (57%), Gaps = 6/179 (3%)
Query: 1042 EGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIV 1101
E F+ T D P ++ LDCEM T+ G ELTR+++V V D VKP+N+I+
Sbjct: 211 ENFLLTKCNGSIADNSP-LFGLDCEMCLTSKGRELTRISLVAEGGCCVMDELVKPENKIL 269
Query: 1102 DYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHSTVVDT 1161
DY T FSG+T+ L + L+DVQ L ++ D +L+GHSL+ DL ALK+IH V+DT
Sbjct: 270 DYLTSFSGITKKILNPVTTKLKDVQRQLKALLPPDAVLVGHSLDLDLRALKMIHPYVIDT 329
Query: 1162 SVLFPHRLGLPYKRSLRNLMADYLRQIIQ--DNVDGHSSSEDAGACMHLVIWKVREDAK 1218
S+L+ G +K L+ L L + IQ D + GH ++EDA + L + ++ K
Sbjct: 330 SLLYVREQGRRFK--LKFLAKVILGKDIQCPDRL-GHDATEDARTILELARYFLKHGPK 385
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 79.7 bits (195), Expect = 2e-14
Identities = 160/704 (22%), Positives = 221/704 (31%), Gaps = 117/704 (16%)
Query: 116 TREHRSAEA-PALAPRGPNASPTVGPDEDA--FPLAFDYSPGSHGLLSPDAGYQPTPLAA 172
T H+ A PA P P P + A P A SP P G TP A
Sbjct: 1119 TPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAAT 1178
Query: 173 PAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSR-PPTD 231
P P GG PK + P P G + + PT
Sbjct: 1179 PPSPK------------------GGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220
Query: 232 LEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSED 291
P S A P +G P TP PK P
Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG-PATPPPKGAPTP------------- 1266
Query: 292 EAATVPGNEPTTASTP-KARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQ 350
AAT P + A+ P K +P + P G T
Sbjct: 1267 PAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGT 1326
Query: 351 PPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEK 410
PPP +P V G P G P PS K+G T +G P
Sbjct: 1327 PPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSH-KGGPAMT 1385
Query: 411 PRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRP---SPTSGDSRP 467
P + K+GP SP K P+S + S K P P R +P+ GD P
Sbjct: 1386 PPSPKRGPAIPSP----------KGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTP 1435
Query: 468 AAGRGPPRPLQLPDRKSTKAPSGKLVERKAR------SLDEGASQDAPKLKKRALSHADL 521
A P+ L +T AP G ++ ++ + ++ P K+ A S +
Sbjct: 1436 PA----VTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPK 1491
Query: 522 FGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSD--------------SSLGFPEAQGPP 567
+ P +P+V PS+ + + S D ++L EA PP
Sbjct: 1492 KAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPP 1551
Query: 568 -------KRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIF 620
K+ A P P AP++ SS +S+ A Y P E +
Sbjct: 1552 AMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGA-------PSPKELLIPPA 1604
Query: 621 NESTSVKTEDRGRLARQPPKEEKS----EEKGLSGLTTLFPGQKR-----RISHLSKQGQ 671
S S K E A PP EK KG + P + S K G
Sbjct: 1605 VTSPSPK-EAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGA 1663
Query: 672 EVEPPRRGPAVPPARPPTA-QEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAP--- 727
V P+ +P + PTA +EV A + S ++ AP R ++ ++P
Sbjct: 1664 TV--PQASKGLPAKKGPTALKEVLVAPAPE----STPIITAPTRKGPQTKKSSATSPPIC 1717
Query: 728 -------GEKRRIAHI-PNPRLAAAPTGAKRTLAASGSQSSNGP 763
G K ++ + P P L +K S S GP
Sbjct: 1718 PDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGP 1761
Score = 75.1 bits (183), Expect = 4e-13
Identities = 129/526 (24%), Positives = 168/526 (31%), Gaps = 95/526 (18%)
Query: 257 KRPRGSRGSE-PYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEI 315
KRP +GS P TP L P +A F + + P T +P P
Sbjct: 806 KRPPTKKGSAGPDTPIGN-LSSPVSPVEASFLPENSLSFQGSKDSPATTHSP---TPPSP 861
Query: 316 KATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQS---SQDGGCPK 372
K P + L +G L KET V +L P PA+PA Q+ S PK
Sbjct: 862 KGAPTPSAVTPLSPKGVTL-PPKETPTP-SVVNLPFPKEGPATPAPKQAPALSMTSSSPK 919
Query: 373 EGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEG 432
+ + G P +PS K P P + K GP SP+ P
Sbjct: 920 KARATPAPKGIPASPSPKGAPTP-----------PAATPPSPKGGPATPSPKWAPTPPAA 968
Query: 433 TKKKPSSATPVATSGKGRPDRPARRP-SPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGK 491
T P P S KG P PA P SP G + P+ P P P S K
Sbjct: 969 TPPSPKGG-PATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPP--SPKGSPAA 1025
Query: 492 LVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGP---GVPSVWPSALPSLSS 548
K S A+ +PK AA P G P+ + LPS
Sbjct: 1026 TPFPKGASTPPAATPPSPK----------------GSPAATPLPKGAPTTPAATLPSPKG 1069
Query: 549 DSDSDSDSSLGFPEAQGP--PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEV 606
+ S P A P PK A+P P AP +++ S A +
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAP--- 1126
Query: 607 DFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHL 666
+ +G LA PPK P
Sbjct: 1127 --------------TTPAATPPSPKGGLATPPPKGA--------------PTTPAATPPS 1158
Query: 667 SKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVH--I 724
K G PP+ P P A PP + + A+ S AP A PS +
Sbjct: 1159 PKGGLATPPPKGAPTTPAATPP---------SPKGGLATPSPKGAPTTPAATPPSPKGGL 1209
Query: 725 SAPGEK----RRIAHIPNPR---LAAAPTGAKRTLAASGSQSSNGP 763
+ P K A P+P+ +P GA T AA+ GP
Sbjct: 1210 ATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGP 1255
Score = 70.1 bits (170), Expect = 1e-11
Identities = 151/691 (21%), Positives = 214/691 (30%), Gaps = 101/691 (14%)
Query: 124 APALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLA 183
+P AP P A+P P P +P G +P A P+P PA P K +
Sbjct: 958 SPKWAPTPPAATP---PSPKGGPA----TPSPKGAPTPPAATPPSPKGGPATPSPKGAPT 1010
Query: 184 SLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYV---VDNSRPPTDLEYDPLSNY 240
G A + PK S P + P P G + P T P
Sbjct: 1011 PPAVTPPSPKGSPAATPF-PKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG 1069
Query: 241 SARHLSRASSRDERAAKRPRGSRGSEPYTPAPK-----KLCDPFGSCDARFSDSEDEAAT 295
S + AA P G P TP+PK P + A T
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPKGG--PATPSPKGAPMPPAATPPSPKGGLATPPHKGAPT 1127
Query: 296 VPGNEPTTA----STPKARADPEIKATGQPPSKEGLEAEGG-GLRETKETAVQCDVGDLQ 350
P P + +TP + P A P K GL G T G L
Sbjct: 1128 TPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA 1187
Query: 351 PPPAK--PASPAQVQSSQDGGC------------------PKEGKPKKKKTGAPPAPSCK 390
P K P +PA S GG PK G GAP P+
Sbjct: 1188 TPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT 1247
Query: 391 DGAQ--GKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGK 448
+ G KG P KG A+ P + A P P + K
Sbjct: 1248 PPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPK 1307
Query: 449 GRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDA 508
G P PA P G + G PP+ P + +P G
Sbjct: 1308 GAPTPPAATPPSPKG----SPGTPPPKGAPTPPAVTPPSPKG-----------------T 1346
Query: 509 PKLKKRALSHADLFGDESEDEAAGPGVPSVWPS--ALPSLSSDSDSDSDSSLGFPEAQGP 566
P L A + + G + GP P+ PS P+++ S + P +G
Sbjct: 1347 PTLP--ATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPA---IPSPKGD 1401
Query: 567 PKRLKASP-PPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTS 625
P P P AP++ + + + + D+ A+ V P + + S
Sbjct: 1402 PTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAV-TPVSLKKAPATSAPKGGPATPS 1460
Query: 626 VKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPA 685
K + P +E K ++ S K+ P P +P
Sbjct: 1461 SKGDPTLPAVTPPSPKEPPAPKQVA------------TSSSPKKAPATPAPMGAPTLPAV 1508
Query: 686 RPPTAQEV----CYLRAQQAQRASASLLQAPARLAEKS----PSVHISAPGEKRRIAHIP 737
P + +EV R A A+ + PA LA K P++ + +P ++ IP
Sbjct: 1509 IPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSP---KKTPAIP 1565
Query: 738 NPRLAAAPTGAKRTL---AASGSQSSNGPEP 765
P+ A A +K A + S P P
Sbjct: 1566 TPKEAPATPSSKEASSPPAVTPSTYKGAPSP 1596
Score = 65.9 bits (159), Expect = 2e-10
Identities = 161/733 (21%), Positives = 228/733 (31%), Gaps = 96/733 (13%)
Query: 119 HRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGS 178
H SA AP + SP P ED+ A S G+ L+ P+PL P +
Sbjct: 756 HTSALAPVAS------SPKECPTEDSGASATASSKGTLTYLADS----PSPLGVSVSPQT 805
Query: 179 KYSLASLDRGQGRGGGGGG--ALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDP 236
K R + G G + + VS P S + P T P
Sbjct: 806 K-------RPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTP 858
Query: 237 LSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATV 296
S A S + P+G TP P + PF E A
Sbjct: 859 PSPKGAPTPSAVTPLS------PKGVTLPPKETPTPSVVNLPF--------PKEGPATPA 904
Query: 297 PGNEP----TTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKE--TAVQCDVGDLQ 350
P P T++S KARA P K PS +G + + A
Sbjct: 905 PKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT 964
Query: 351 PPPAKPASPA---QVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRP 407
PP A P SP S + P P K G P PS K T +G P
Sbjct: 965 PPAATPPSPKGGPATPSPKGAPTPPAATPPSPK-GGPATPSPKGAPTPPAVTPPSPKGSP 1023
Query: 408 VEKP--RADKKGPQASSPRRKAER-----PEGTKKKPSSATPVATSG------KGRPDRP 454
P + P A+ P K P+G P++ P G KG P P
Sbjct: 1024 AATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPP 1083
Query: 455 ARR-PSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLV--ERKARSLDEGASQDAPKL 511
A PSP G + P+ P+ +P + +P G L K A+ +P
Sbjct: 1084 AATPPSPKGGPATPS-----PKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSP-- 1136
Query: 512 KKRALSHADLFGDESEDEAAGP----GVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPP 567
K L+ G + A P G+ + P P+ + + L P +G P
Sbjct: 1137 -KGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAP 1195
Query: 568 KRLKASPP--------PSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRI 619
A+PP PSP + ++ +++ S G S + P
Sbjct: 1196 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP---- 1251
Query: 620 FNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTL----FPGQKRRISHLSKQGQEVEP 675
+ +G A PP KG GL T P K G P
Sbjct: 1252 --KGGPATPPPKG--APTPPAATPPSLKG--GLATPPHKGAPNPAVVTPPSPKGGPATSP 1305
Query: 676 PRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAH 735
P+ P P A PP+ + + ++ + P+ S+ G +
Sbjct: 1306 PKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSS 1365
Query: 736 IPNPRLAAAPTGAKRTLAASGSQSSNG---PEPGGQQLKTRTLSGMASKTTTTIIPKRIA 792
P AA K A + G P P G + K T + + A
Sbjct: 1366 KEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGA 1425
Query: 793 HSPSLQSLKKPII 805
+PS L P +
Sbjct: 1426 ATPSKGDLTPPAV 1438
Score = 35.4 bits (80), Expect = 0.33
Identities = 76/344 (22%), Positives = 101/344 (29%), Gaps = 79/344 (22%)
Query: 292 EAATVPGNEPTTA---STPKARADPEIKATGQPPSKEGLEAEGG--GLRETKETAVQCDV 346
E+A G PTTA ST A P ++ T K EG L + C V
Sbjct: 651 ESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPV 710
Query: 347 GDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDK-------- 398
P P +P P G PP DG
Sbjct: 711 A---PSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSP 767
Query: 399 ----TKDKGRGRPVEKPR-----ADKKGPQASSPRRKAERPEGTKKKPSSATPVAT---- 445
T+D G AD P S + +RP K TP+
Sbjct: 768 KECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSP 827
Query: 446 --------------SGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGK 491
S +G D PA SPT P + +G P P + + +P G
Sbjct: 828 VSPVEASFLPENSLSFQGSKDSPATTHSPT-----PPSPKGAPTPSAV----TPLSPKGV 878
Query: 492 LVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSD 551
+ K + PK GP P+ P P+LS S
Sbjct: 879 TLPPKETPTPSVVNLPFPK--------------------EGPATPA--PKQAPALSMTSS 916
Query: 552 SDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGA 595
S + A PK + ASP P AP+ +++ S A
Sbjct: 917 SPKKA-----RATPAPKGIPASPSPKGAPTPPAATPPSPKGGPA 955
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 74.7 bits (182), Expect = 5e-13
Identities = 107/471 (22%), Positives = 174/471 (36%), Gaps = 62/471 (13%)
Query: 252 DERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARF-SDSEDEA--------ATVPGNEPT 302
DE K+ +G +P A K S D+ S SEDE V T
Sbjct: 137 DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQT 196
Query: 303 TASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKE---------TAVQCDVGDLQPPP 353
A ARA P+I A G+ S + +++E T + V P
Sbjct: 197 KAPPKPARAAPKI-ANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVK 255
Query: 354 AKPASPAQVQSSQDGGCPKEG---KPKKKKTGA------PPAPSCKDGAQGKDKTKDKGR 404
A + SS+D +E KP K K G P AP K + K +
Sbjct: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEK 315
Query: 405 GRPVEKPR-----------ADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDR 453
+PVE +KK P + + +P KK S++ + S D
Sbjct: 316 QQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375
Query: 454 PARRPSPTSGDS--RPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSL---DEGASQDA 508
+P+ T+ +S +PA P K KL+ RKA S +E +S +
Sbjct: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE 435
Query: 509 PKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPE------ 562
K KK + ++ +A S+ P S DS SDSDSS E
Sbjct: 436 EKTKKMVAT--------TKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSK 487
Query: 563 --AQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIF 620
+ P+++ PS S+ + S++S+ +D E+++ P + +
Sbjct: 488 SAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKA- 546
Query: 621 NESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQ 671
TS T G+ A+ +EE+ ++K ++ +KR+ + +K+ +
Sbjct: 547 -NGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAE 596
Score = 46.2 bits (108), Expect = 2e-04
Identities = 99/421 (23%), Positives = 146/421 (34%), Gaps = 91/421 (21%)
Query: 425 RKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKS 484
+ A+ PE +K + PVA K + A +GPP K
Sbjct: 59 KSAKVPE---RKLQANGPVAKKAK----KKASSSDSEDSSEEEEEVQGPPAKKAAVPAKR 111
Query: 485 TKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALP 544
P GK + + S S D D+ ED+ P V P A
Sbjct: 112 VGLPPGKAAAKASESSSSEESSD---------------DDDEEDQKKQPVQKGVKPQAKA 156
Query: 545 SL-------SSDSDSDSDSSLGFPEAQ--------------GPPKRLKASPPPSPAPSSS 583
+ SSDSDSDS S P+ Q PPK +A+P + ++S
Sbjct: 157 AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAAS 216
Query: 584 SSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEK 643
SSSSSS+SS+ D S EK +T KT PK++
Sbjct: 217 SSSSSSSSSSSDD---SEEEKAA----------------ATPKKT---------VPKKQV 248
Query: 644 SEEKGLSGLTTLFPGQKRRISHLSKQGQEVE---PPRRGP-----AVPPARPPTAQEVCY 695
+ + TT P +K S S +E E P + P PP+ PP +
Sbjct: 249 VAKAPVKAATT--PTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKS--- 303
Query: 696 LRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAAS 755
L Q ++A Q P +E S S+ E+++ P + + K A
Sbjct: 304 LGTQPPKKAVEK--QQPVESSEDSSDESDSSSEEEKK----PPTKAVVSKATTKPPPAKK 357
Query: 756 GSQSSNGPEPGGQQLKTRTLSGMASKT-TTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVP 814
++SS+ S A T ++ P SP+++ P P G K+
Sbjct: 358 AAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417
Query: 815 T 815
T
Sbjct: 418 T 418
Score = 40.0 bits (92), Expect = 0.014
Identities = 49/217 (22%), Positives = 87/217 (40%), Gaps = 27/217 (12%)
Query: 248 ASSRDERAAK-----RPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPT 302
+SS +E+ K +P+ + + PA + P GS D+ S D +++ E T
Sbjct: 431 SSSEEEKTKKMVATTKPKATAKAALSLPAKQA---PQGSRDS--SSDSDSSSSEEEEEKT 485
Query: 303 TASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQV 362
+ S K + P+ A G PSK +G E+ ++ D +S +
Sbjct: 486 SKSAVKKK--PQKVAGGAAPSKPASAKKGKA--ESSNSSSSDD-----------SSEEEE 530
Query: 363 QSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASS 422
+ + G P+ PK T A A + K +++ ++K + V K + +
Sbjct: 531 EKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNE 590
Query: 423 PRRKAERPEGTKKK--PSSATPVATSGKGRPDRPARR 457
++AE P+ K K + P G+ R P RR
Sbjct: 591 AAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRR 627
>gi|194239666 interferon stimulated exonuclease gene 20kDa-like 1
[Homo sapiens]
Length = 325
Score = 74.7 bits (182), Expect = 5e-13
Identities = 59/178 (33%), Positives = 90/178 (50%), Gaps = 18/178 (10%)
Query: 1053 SGDTHPGIYALDCEMSYTTYG---LELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSG 1109
SG A+DCEM T EL R ++V +V+YD +++P+ I DY TR+SG
Sbjct: 103 SGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSG 162
Query: 1110 VTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIH--STVVDTSVLFPH 1167
+T + +V + Q +L + +++GH+L +D ALK +H S DT+ + P+
Sbjct: 163 ITRQHMR-KAVPFQVAQKEILKLLKG-KVVVGHALHNDFQALKYVHPRSQTRDTTYV-PN 219
Query: 1168 RLGLP-----YKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHL-----VIWKVRE 1215
L P + SL++L L + IQ GHSS EDA M L V W+ +E
Sbjct: 220 FLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQE 277
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 73.9 bits (180), Expect = 8e-13
Identities = 186/810 (22%), Positives = 286/810 (35%), Gaps = 157/810 (19%)
Query: 20 PGGPCRRPYCHFRHRGARGS-----GAPGDGGEAPPAAGLGYDPYNPELP--KPPA---- 68
PGGP R R AR + A G G A + G G + ELP +PP+
Sbjct: 1419 PGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPAD 1478
Query: 69 ---QRENGTLGLGE-------EPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTRE 118
+ T G G P + + N + E + R +
Sbjct: 1479 KDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFT 1538
Query: 119 HRSAEAPALAPRGPNASPTVGPDEDAFP-LAFDYSPGSHGLLSPDAGY-QPTPLAAPA-E 175
+ AP A+P P P L D +P + L S + +P P PA
Sbjct: 1539 RERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVH 1598
Query: 176 PGSKYSLASLDRGQGRGGGGG----GALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTD 231
P + + D G G G A E + + +S RP SG
Sbjct: 1599 PRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGL----------- 1647
Query: 232 LEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSED 291
R RA+ DER A+ R RG E GS A DS +
Sbjct: 1648 ----------RRRKPRATRLDERPAEGSR-ERGEEAA-----------GSDRASDLDSVE 1685
Query: 292 EAATVPGNEPTTASTPKARADPEIKATGQPPSK-EGLEAEGGGLRETKETAVQCDVGD-L 349
A G +A A AT + S+ + + + GL VG L
Sbjct: 1686 WRAIQEGANSIVTWLHQAAA-----ATREASSESDSILSFVSGL----------SVGSTL 1730
Query: 350 QPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKG----RG 405
QPP + A+ + K G K +G+P +P+ + +G KT RG
Sbjct: 1731 QPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRG 1790
Query: 406 RPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDS 465
R V SP +A+ P+GT ++ VA +P PA+ PSP G
Sbjct: 1791 RTV---------IYVPSPAPRAQ-PKGTPGPRATPRKVAPPCLAQPAAPAKVPSP--GQQ 1838
Query: 466 RPAAGRGPPRPLQL-----PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHAD 520
R + P + +L P R +T P +L + + S + + P +KR
Sbjct: 1839 RSRSLHRPAKTSELATLSQPPRSAT--PPARLAKTPSSSSSQTSPASQPLPRKRPPV--- 1893
Query: 521 LFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQ-----GPPKRLKASPP 575
++ GPG V + +L + S + P Q GPP +A P
Sbjct: 1894 ---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPE 1950
Query: 576 PSPAPSSSSSS--------------SSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFN 621
P P + + + +S+ SS D S +++ F ++E +
Sbjct: 1951 PGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTF----IKESPGLRR 2006
Query: 622 ESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVE-PPRRGP 680
+ + + + A Q S +G L +F S + +E+ PR+GP
Sbjct: 2007 RRSELSSAESAASAPQ----GASPRRGRPALPAVF--------LCSSRCEELRAAPRQGP 2054
Query: 681 AVPPARPPTAQEVCYLRAQQAQR-ASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNP 739
A RPP A R +R A + ++P+RL ++P+ + P +R A +P+
Sbjct: 2055 APARQRPPAA------RPSPGERPARRTTSESPSRLPVRAPA---ARPETVKRYASLPHI 2105
Query: 740 RLAAAPTGAKRTLAASGS---QSSNG-PEP 765
+A P GA AS +SS+G P P
Sbjct: 2106 SVARRPDGAVPAAPASADAARRSSDGEPRP 2135
Score = 52.8 bits (125), Expect = 2e-06
Identities = 130/596 (21%), Positives = 198/596 (33%), Gaps = 113/596 (18%)
Query: 209 PRRHSRPVPSGKYVVDNSRPPT---DLEYDPLSNYSARHLSRASSRDERAAKRPR----G 261
P R + PVP Y++ + P D D S AS DE PR G
Sbjct: 1364 PGRRALPVPV--YMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGG 1421
Query: 262 SRGSEPYTPAPKKLCDPFG------SCDARFSDSEDEAATVPGNEPTTASTPKARADPEI 315
G + T P G S G E P A AD +
Sbjct: 1422 PAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDG 1481
Query: 316 KATGQPPSKEGLEAEGGGLRETKETAVQCDVG---DLQPPPAKPASPAQVQSSQDGGCPK 372
G+ L++ L E AV C G D +PP A P
Sbjct: 1482 SKPGRTRGDGALQSLC--LTTPTEEAVYCFYGNDSDEEPPAAAPT--------------- 1524
Query: 373 EGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGP---QASSPRRKAER 429
P ++T A P ++ QG+ + + P P A + + P
Sbjct: 1525 ---PTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSS 1581
Query: 430 PEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQ------LPDRK 483
+ +P + P A +GR + P P G + R LQ LP R
Sbjct: 1582 SASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRR- 1640
Query: 484 STKAPSGKLVERKARS--LDEGASQDAPKLKKRALSH---ADLFGDESEDEAAGPGVPSV 538
+ P L RK R+ LDE ++ + + + A +DL D E A G S+
Sbjct: 1641 --RPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDL--DSVEWRAIQEGANSI 1696
Query: 539 --WPSALPSLSSDSDSDSDSSLGFPEAQG------PPKRLKASPPPSPAPSSSSSSSSST 590
W + + ++ S+SDS L F PPK K S+
Sbjct: 1697 VTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGR-----QAEGEMGSARRP 1751
Query: 591 SSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLS 650
GA SVKT R + P++ + +K
Sbjct: 1752 EKRGA----------------------------ASVKTSGSPR-SPAGPEKPRGTQKTTP 1782
Query: 651 GLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQ 710
G+ + G R + ++ +P +G P A P C AQ A+ + +
Sbjct: 1783 GVPAVLRG--RTVIYVPSPAPRAQP--KGTPGPRATPRKVAPPCL-----AQPAAPAKVP 1833
Query: 711 APARLAEKSPSVHISAPGEKRRIAHIPN-PRLAAAPTGAKRTLAASGSQSSNGPEP 765
+P + ++S S+H P + +A + PR A P +T ++S SQ+S +P
Sbjct: 1834 SPGQ--QRSRSLH--RPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQP 1885
Score = 42.0 bits (97), Expect = 0.004
Identities = 71/327 (21%), Positives = 116/327 (35%), Gaps = 61/327 (18%)
Query: 307 PKARADPEIKATGQPPSKEGLEAEGG-------------GLRETKETAVQCDVGDLQPPP 353
P ARA PE G+ ++ G A GG G + + + + ++ P
Sbjct: 1943 PLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESP 2002
Query: 354 AKPASPAQVQSSQD-GGCPKEGKPKKKKTGAPPAPSC-----------KDGAQGKDKTKD 401
+++ S++ P+ P++ + P C + G +
Sbjct: 2003 GLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPP 2062
Query: 402 KGRGRPVEKP--RADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPS 459
R P E+P R + P R A RPE T K+ +S ++ + RPD A +
Sbjct: 2063 AARPSPGERPARRTTSESPSRLPVRAPAARPE-TVKRYASLPHISVA--RRPD-GAVPAA 2118
Query: 460 PTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRAL--S 517
P S D+ + G PRPL + + R+ R +D P + + L +
Sbjct: 2119 PASADAARRSSDGEPRPL-------PRVAAPGTTWRRIR------DEDVPHILRSTLPAT 2165
Query: 518 HADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPS 577
L G ED AGP P +SD+ ++ E P SP
Sbjct: 2166 ALPLRGSTPEDAPAGPP---------PRKTSDAVVQTE------EVAAPKTNSSTSPSLE 2210
Query: 578 PAPSSSSSSSSSTSSAGADVDYSALEK 604
+ + S G+DVD +L K
Sbjct: 2211 TREPPGAPAGGQLSLLGSDVDGPSLAK 2237
Score = 36.2 bits (82), Expect = 0.20
Identities = 67/241 (27%), Positives = 92/241 (38%), Gaps = 25/241 (10%)
Query: 118 EHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGL-LSPDAGYQPT---PLAAP 173
E SAE+ A AP+G ASP G A P F S L +P G P P AA
Sbjct: 2010 ELSSAESAASAPQG--ASPRRG--RPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAAR 2065
Query: 174 AEPGSKYSLASLDRGQGRGGGGGGAL--EYVPKAVSQP-----RRHSRPVPSGKYVVDNS 226
PG + + + R A E V + S P RR VP+ D +
Sbjct: 2066 PSPGERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAA 2125
Query: 227 RPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCD----PFGSC 282
R +D E PL +A + RDE P R + P T P + P G
Sbjct: 2126 RRSSDGEPRPLPRVAAPGTTWRRIRDEDV---PHILRSTLPATALPLRGSTPEDAPAGPP 2182
Query: 283 DARFSDS--EDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKET 340
+ SD+ + E P +T+ + + R P A GQ S G + +G L + +
Sbjct: 2183 PRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQ-LSLLGSDVDGPSLAKAPIS 2241
Query: 341 A 341
A
Sbjct: 2242 A 2242
Score = 32.0 bits (71), Expect = 3.7
Identities = 66/286 (23%), Positives = 97/286 (33%), Gaps = 22/286 (7%)
Query: 304 ASTPKARADPEIKATGQP-PSKEGLEAEGGGLRETKETAVQCD--VGDLQPPPAKPASPA 360
A+ R DP GQP PS+ L+ G A D V ++ P P
Sbjct: 948 AALASRREDPRC---GQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPL 1004
Query: 361 QVQSSQDGGCPKEG---KPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKG 417
+S+ G P G P +K PA + + ++K A +
Sbjct: 1005 LEGASRAGAEPLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGP 1064
Query: 418 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPL 477
S + + PS + S PS DS A P+
Sbjct: 1065 LSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPV 1124
Query: 478 QLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPS 537
+P + + + + S E Q+ P + R S + L ES P + S
Sbjct: 1125 AIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFES------PSIAS 1178
Query: 538 VWPSALPSLSSDSDSDSDSSLGFPEAQG---PPKRLKASPPPSPAP 580
PS P S + S S L P++ G PP R K +PP +PAP
Sbjct: 1179 SIPSE-PCSGQGSGTISPSEL--PDSPGQTMPPSRSK-TPPLAPAP 1220
>gi|6857800 interferon stimulated exonuclease [Homo sapiens]
Length = 181
Score = 71.6 bits (174), Expect = 4e-12
Identities = 54/157 (34%), Positives = 78/157 (49%), Gaps = 10/157 (6%)
Query: 1060 IYALDCEMSYTTYGLE--LTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLAD 1117
+ A+DCEM E L R ++V+ V+YD F++P+ EI DY TR SGVT +
Sbjct: 7 VVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVTPQHM-- 64
Query: 1118 TSVTLRDVQAVLLSMFSADTILIGHSLESDLLALK------VIHSTVVDTSVLFPHRLGL 1171
T V + + +++GH L+ D ALK I+ T D + +L
Sbjct: 65 VGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREAKLDH 124
Query: 1172 PYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHL 1208
+ SLR L L + IQ+++ GHSS EDA A M L
Sbjct: 125 CRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMEL 161
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 70.5 bits (171), Expect = 9e-12
Identities = 120/482 (24%), Positives = 174/482 (36%), Gaps = 81/482 (16%)
Query: 118 EHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPG 177
+H A +P L PR P G +ED L D L + AP P
Sbjct: 563 DHEPAVSPLL-PRKERGPPEGGLNEDERLLPKDKKTNLFSAL-----IKKKKKTAPTPPK 616
Query: 178 SKYSLASLDRGQGRGGGG--------GGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPP 229
S +D R G G GAL + P + P + P PS V N
Sbjct: 617 RSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKS--PKPSNGAGVPNGA-- 672
Query: 230 TDLEYDPLSNYSARHLSRASSR--DERAA--KRPRGSRGSEPYTPAPKKLCDPFGSCDAR 285
L S + + HL + SS R A + G S+ + + C P G+ D
Sbjct: 673 --LRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTE 730
Query: 286 F-----------SDSEDEAATVPGNEPTTASTPKARA-----DPEIKATGQPPS---KEG 326
+ + + +++T G++ + P+ RA D + T PP K+
Sbjct: 731 WRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKN 790
Query: 327 LEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPA 386
EA ++ E++ +L P P + Q P G P K++ G A
Sbjct: 791 EEAADEVFKDIMESSPGSSPPNLTPKPLR---------RQVTVAPASGLPHKEEAGKGSA 841
Query: 387 PSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATS 446
A+ T G G P KGP AE + K SS +P
Sbjct: 842 LGTPAAAEPVTPTSKAGSGAP----GGTSKGP--------AEESRVRRHKHSSESPGRDK 889
Query: 447 GKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKST-KAPSGKLVERKARSLDEGAS 505
GK +PA P P + +AG+ +P Q P +++ +A G + KA SL + +
Sbjct: 890 GKLSRLKPAPPPPPAA-----SAGKAGGKPSQSPSQEAAGEAVLG--AKTKATSLVDAVN 942
Query: 506 QDAPK-------LKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSL 558
DA K LKK L +S + P P+ PS LPS SS D SS
Sbjct: 943 SDAAKPSQPGEGLKKPVLPATPK--PQSAKPSGTPISPAPVPSTLPSASSALAGDQPSST 1000
Query: 559 GF 560
F
Sbjct: 1001 AF 1002
Score = 37.0 bits (84), Expect = 0.11
Identities = 80/340 (23%), Positives = 116/340 (34%), Gaps = 67/340 (19%)
Query: 303 TASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQV 362
TA TP R+ + GQP + E EG + D D P KP++ A V
Sbjct: 610 TAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP-KPSNGAGV 668
Query: 363 QSS---QDGGC----PKEGKPKKKKTGAPPAPSCKDGAQGKDK--------------TKD 401
+ + GG P K T + A ++G K KD
Sbjct: 669 PNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKD 728
Query: 402 KGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPT 461
R V PR S+ R+ G K A P +G+ R D+ R
Sbjct: 729 T-EWRSVTLPR-----DLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTR----- 777
Query: 462 SGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADL 521
G P PPR + +K+ +A + S PK +R ++ A
Sbjct: 778 -GTVTP-----PPRLV----KKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPA 827
Query: 522 FGDESEDEA---AGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEA--------------- 563
G ++EA + G P+ P+ + S + +S G E
Sbjct: 828 SGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGR 887
Query: 564 -QGPPKRLKASPPPSPAPSSSS-----SSSSSTSSAGADV 597
+G RLK +PPP PA S+ S S S +AG V
Sbjct: 888 DKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAV 927
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 70.5 bits (171), Expect = 9e-12
Identities = 120/482 (24%), Positives = 174/482 (36%), Gaps = 81/482 (16%)
Query: 118 EHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPG 177
+H A +P L PR P G +ED L D L + AP P
Sbjct: 582 DHEPAVSPLL-PRKERGPPEGGLNEDERLLPKDKKTNLFSAL-----IKKKKKTAPTPPK 635
Query: 178 SKYSLASLDRGQGRGGGG--------GGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPP 229
S +D R G G GAL + P + P + P PS V N
Sbjct: 636 RSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKS--PKPSNGAGVPNGA-- 691
Query: 230 TDLEYDPLSNYSARHLSRASSR--DERAA--KRPRGSRGSEPYTPAPKKLCDPFGSCDAR 285
L S + + HL + SS R A + G S+ + + C P G+ D
Sbjct: 692 --LRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTE 749
Query: 286 F-----------SDSEDEAATVPGNEPTTASTPKARA-----DPEIKATGQPPS---KEG 326
+ + + +++T G++ + P+ RA D + T PP K+
Sbjct: 750 WRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKN 809
Query: 327 LEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPA 386
EA ++ E++ +L P P + Q P G P K++ G A
Sbjct: 810 EEAADEVFKDIMESSPGSSPPNLTPKPLR---------RQVTVAPASGLPHKEEAGKGSA 860
Query: 387 PSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATS 446
A+ T G G P KGP AE + K SS +P
Sbjct: 861 LGTPAAAEPVTPTSKAGSGAP----GGTSKGP--------AEESRVRRHKHSSESPGRDK 908
Query: 447 GKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKST-KAPSGKLVERKARSLDEGAS 505
GK +PA P P + +AG+ +P Q P +++ +A G + KA SL + +
Sbjct: 909 GKLSRLKPAPPPPPAA-----SAGKAGGKPSQSPSQEAAGEAVLG--AKTKATSLVDAVN 961
Query: 506 QDAPK-------LKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSL 558
DA K LKK L +S + P P+ PS LPS SS D SS
Sbjct: 962 SDAAKPSQPGEGLKKPVLPATPK--PQSAKPSGTPISPAPVPSTLPSASSALAGDQPSST 1019
Query: 559 GF 560
F
Sbjct: 1020 AF 1021
Score = 37.0 bits (84), Expect = 0.11
Identities = 80/340 (23%), Positives = 116/340 (34%), Gaps = 67/340 (19%)
Query: 303 TASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQV 362
TA TP R+ + GQP + E EG + D D P KP++ A V
Sbjct: 629 TAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP-KPSNGAGV 687
Query: 363 QSS---QDGGC----PKEGKPKKKKTGAPPAPSCKDGAQGKDK--------------TKD 401
+ + GG P K T + A ++G K KD
Sbjct: 688 PNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKD 747
Query: 402 KGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPT 461
R V PR S+ R+ G K A P +G+ R D+ R
Sbjct: 748 T-EWRSVTLPR-----DLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTR----- 796
Query: 462 SGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADL 521
G P PPR + +K+ +A + S PK +R ++ A
Sbjct: 797 -GTVTP-----PPRLV----KKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPA 846
Query: 522 FGDESEDEA---AGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEA--------------- 563
G ++EA + G P+ P+ + S + +S G E
Sbjct: 847 SGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGR 906
Query: 564 -QGPPKRLKASPPPSPAPSSSS-----SSSSSTSSAGADV 597
+G RLK +PPP PA S+ S S S +AG V
Sbjct: 907 DKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAV 946
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 68.9 bits (167), Expect = 3e-11
Identities = 103/484 (21%), Positives = 165/484 (34%), Gaps = 52/484 (10%)
Query: 141 DEDAFPLAFDYS-----PGSH-GLLSPDAGYQ---PTPLAAPAEPGSKYSLASLDRGQGR 191
D D + FD P SH LL PD Q P+P + S D G+G+
Sbjct: 2256 DGDLITVEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGK 2315
Query: 192 GGGGGGALEYVPKAVSQPRRHSRPVPSGK-YVVDNSRPPTDLEYDPLSNYSARHLSRASS 250
GG G+ E KA + R+ S + ++ P ++ PL+ + S
Sbjct: 2316 DGGTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKS 2375
Query: 251 RDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKAR 310
E KR + + + P P P F SC A +E A + P R
Sbjct: 2376 PPEPVDKRAKAPK-ARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITMPATR 2434
Query: 311 ADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDG-G 369
P+ + +G G E E V+ D + P +K A A + G G
Sbjct: 2435 PKPKKARAAEESGAKGPRRPG----EEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAG 2490
Query: 370 CPKEGKPKKKKTGAPPA----------PSCKDGAQGKD-----KTKDKGRGRPVEKPRAD 414
+E K PPA P DG ++ +D G + +K +A+
Sbjct: 2491 GWQEPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAE 2550
Query: 415 KKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDR------------------PAR 456
+ G + S + + SS++ T G+ D+ A
Sbjct: 2551 QDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAA 2610
Query: 457 RPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRAL 516
P+ +S S ++ S+ + S + S +S + +
Sbjct: 2611 SPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2670
Query: 517 SHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPP 576
S D S D+ A P P+ PSA +L + + + + P A P K+ A P
Sbjct: 2671 STTDEDSSCSSDDEAAP-APTAGPSAQAALPTKATKQAGKAR--PSAHSPGKKTPAPQPQ 2727
Query: 577 SPAP 580
+P P
Sbjct: 2728 APPP 2731
Score = 50.8 bits (120), Expect = 8e-06
Identities = 72/287 (25%), Positives = 101/287 (35%), Gaps = 54/287 (18%)
Query: 366 QDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEK-PRADKKGPQASSPR 424
+DGG +P K G PS K A+G D+ G P ++ P +S+P
Sbjct: 2315 KDGGTAGSEEPGAKARGRGRKPSAK--AKG-DRAATLEEGNPTDEVPSTPLALEPSSTPG 2371
Query: 425 RKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPA---------------- 468
K PE K+ A + K RP P P+P + S PA
Sbjct: 2372 SKKSPPEPVDKR-------AKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAP 2424
Query: 469 -------AGRGPPRPLQLPDRKSTKAP--SGKLVERKARSLDEGASQDAPKLKKRAL--- 516
A R P+ + + K P G+ E + EG + K K AL
Sbjct: 2425 APLITMPATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLR 2484
Query: 517 ---------SHADLFGDESEDEAAGPGVPSV-WPSALPSLSSDSDSDSDSSLGFPEAQGP 566
L S AAG P WP A D + L F ++ P
Sbjct: 2485 EDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKA---TDGDLAQEPGPGLTFEDSGNP 2541
Query: 567 --PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSD 611
P + +A + SSSSSSS +SS+ + S E E + + D
Sbjct: 2542 KSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGD 2588
Score = 43.9 bits (102), Expect = 0.001
Identities = 62/246 (25%), Positives = 90/246 (36%), Gaps = 60/246 (24%)
Query: 371 PKEGKPKKKKTGAPPAPSCKDGAQGKDKTK-DKGR-----GRPVEKPRADKK-----GPQ 419
PK+G + + A P P GA+G D + DK + GR K R K+ GP+
Sbjct: 1932 PKKGLGEPGPSLAAPTP----GARGPDPSSPDKAKLAVEKGRKARKLRGPKEPGFEAGPE 1987
Query: 420 ASSP----RRKAERPEGTKKKPSSATPVATS--------GKGRP-----------DRPAR 456
AS RR++ER ++ PV+T+ KG P DR
Sbjct: 1988 ASDDDLWTRRRSERIFLHDASAAAPAPVSTAPATKTSRCAKGGPLSPRKDAGRAKDRKDP 2047
Query: 457 RPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRAL 516
R ++ P AG PPR LP E + A L
Sbjct: 2048 RKKKKGKEAGPGAGLPPPRAPALP--------------------SEARAPHASSLTAAKR 2087
Query: 517 SHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPP 576
S A G E + E G G + S++++ D + + F E + P+ P
Sbjct: 2088 SKAKAKGKEVKKENRGKG--GAVSKLMESMAAEEDFEPNQDSSFSEDEHLPRGGAVERPL 2145
Query: 577 SPAPSS 582
+PAP S
Sbjct: 2146 TPAPRS 2151
Score = 39.3 bits (90), Expect = 0.023
Identities = 85/371 (22%), Positives = 125/371 (33%), Gaps = 67/371 (18%)
Query: 181 SLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNY 240
S+ +GQG GG G Y+P A + HS PS + P +
Sbjct: 150 SIFDTQKGQGPGGDGF----YLPTAGAPGSLHSH-APSAR--------------TPGGGH 190
Query: 241 SARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNE 300
S+ ++ SS + AK R RG EP KK DP AR ++ V +
Sbjct: 191 SSGAPAKGSSSRDGPAKE-RAGRGGEPPPLFGKK--DP----RARGEEASGPRGVVDLTQ 243
Query: 301 PTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASP- 359
A + R P + P E + + L+ + T GD+ P +
Sbjct: 244 EARAEGRQDRGPPRLAERLSPFLAES-KTKNAALQPSVLTMCNGGAGDVGLPALVAEAGR 302
Query: 360 --AQVQSSQDGG----------------CPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKD 401
A+ + QD G CP P PPAP A ++
Sbjct: 303 GGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPPKGPPAPPAATPAGVYTVFRE 362
Query: 402 KGRGRPVEKPR--------ADKKGP--------QASSPRRKAERPEGTKKKPSSATPV-- 443
+GR V P ++ GP A + R+A RP + P S P+
Sbjct: 363 QGREHRVVAPTFVPSVEAFDERPGPIQIASQARDARAREREAGRPGVLQAPPGSPRPLDR 422
Query: 444 --ATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSG-KLVERKARSL 500
K R +RP P + A P +P ++ K + + ER R
Sbjct: 423 PEGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKELLKPEADPRPCERAPRGP 482
Query: 501 DEGASQDAPKL 511
A+Q A KL
Sbjct: 483 AGPAAQQAAKL 493
Score = 32.7 bits (73), Expect = 2.2
Identities = 102/442 (23%), Positives = 147/442 (33%), Gaps = 98/442 (22%)
Query: 33 HRGARGSGAPGDGGEAPPAAGLGYDPYNPELPKPPAQR--------ENGTLGL------- 77
H+G + PG GG P A DP + +L P+ E T+
Sbjct: 828 HQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSDHLPHFAELMERATVPPLWPALYP 887
Query: 78 -GEEPRPDVLELELVNQ------------------AIEAVRS----EVELEQRRYRELLE 114
G P +L+L +Q A+E RS + L+ + +R +E
Sbjct: 888 PGRSPLHHAQQLQLFSQQHFLRQQEFLYLQQQAAQALELQRSAQLVQERLKAQEHRAEME 947
Query: 115 TTREHRSAEAPA---LAPRGPNASPTVGPDEDAFPLAFDYSPGSHG-LLSPDAGYQPTPL 170
R EA LA GP P P A P G++G +SP P+P
Sbjct: 948 EKGSKRGLEAAGKAGLATAGPGLLPRKPPGLAAGPA------GTYGKAVSPP----PSPR 997
Query: 171 AAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPT 230
A+P + L+ VS+P ++ P + S PP
Sbjct: 998 ASPVAALKAKVIQKLED------------------VSKPPAYAYPATPSSH--PTSPPPA 1037
Query: 231 DLEYDP-LSNYSARHLSRASSRD---ERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARF 286
P ++ + +D E+ A P + S+ P + P F
Sbjct: 1038 SPPPTPGITRKEEAPENVVEKKDLELEKEAPSPFQALFSDIPPRYPFQALPPHYGRPYPF 1097
Query: 287 SDSEDEAATVPG---NEPTTASTPKARA-DPEIKATGQPPSK------EGLEAEGGGLRE 336
AA G + P A P+ A PE K PSK EG E E RE
Sbjct: 1098 LLQPTAAADADGLAPDVPLPADGPERLALSPEDKPIRLSPSKITEPLREGPEEEPLAERE 1157
Query: 337 TKETAVQCDVGDLQPPPAK-----PASPAQVQSSQDGGC-----PKEGKPKKKKTGAPPA 386
K D G + PP + PA+ A S GGC + ++ A P+
Sbjct: 1158 VKAEVEDMDEGPTELPPLESPLPLPAAEAMATPSPAGGCGGGLLEAQALSATGQSCAEPS 1217
Query: 387 PSCKDGAQGKDKTKDK-GRGRP 407
C D +G + D GR P
Sbjct: 1218 -ECPDFVEGPEPRVDSPGRTEP 1238
Score = 32.3 bits (72), Expect = 2.8
Identities = 67/310 (21%), Positives = 109/310 (35%), Gaps = 37/310 (11%)
Query: 437 PSSATPVATSGKGRP-------DRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPS 489
PS+ TP G P D PA+ + G+ P G+ PR + P
Sbjct: 181 PSARTPGGGHSSGAPAKGSSSRDGPAKERAGRGGEPPPLFGKKDPR----ARGEEASGPR 236
Query: 490 GKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPS-----ALP 544
G +V+ + EG P LS L ++++ A P V ++ LP
Sbjct: 237 G-VVDLTQEARAEGRQDRGPPRLAERLS-PFLAESKTKNAALQPSVLTMCNGGAGDVGLP 294
Query: 545 SLSSDS----------DSDSDSSLGFPEAQGPPKRLKASP-PPSPAPSSSSSSSSSTSSA 593
+L +++ + L E P R SP PP PAP + + + A
Sbjct: 295 ALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPPKGPPAPPAATPA 354
Query: 594 GADVDYSALEKEVDFDSDPMEECLRIFNESTS-VKTEDRGRLARQPPKEEKSEEKGLSGL 652
G + +E + + F+E ++ + R AR + E G G+
Sbjct: 355 GVYTVFREQGREHRVVAPTFVPSVEAFDERPGPIQIASQARDAR-----AREREAGRPGV 409
Query: 653 TTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLL--Q 710
PG R + ++ R PPA PT + +A + LL +
Sbjct: 410 LQAPPGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKELLKPE 469
Query: 711 APARLAEKSP 720
A R E++P
Sbjct: 470 ADPRPCERAP 479
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 68.6 bits (166), Expect = 4e-11
Identities = 101/536 (18%), Positives = 197/536 (36%), Gaps = 66/536 (12%)
Query: 242 ARHLSRASSRDERAAKRPRGSRGSEPY-TPAPKKLCDPFGSCDARFSDSEDEAATVPGNE 300
A+ + A S ++ AK P + E +PA ++ P +A+ + E+ +
Sbjct: 524 AKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP---PEAKSPEKEEAKSPAEVKS 580
Query: 301 PTTASTP-KARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASP 359
P A +P K A +A +K ++ E E K P + SP
Sbjct: 581 PEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS-----------PVKEEAKSP 629
Query: 360 AQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKD--KGRGRPVEKPRADKKG 417
A+V+S + P + + K + P K+ A+ +K K K + EK ++ K
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPE---KEEAKSPEKAKSPVKAEAKSPEKAKSPVKA 686
Query: 418 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPL 477
S + K+ E K + +PV K P + SP +++ P
Sbjct: 687 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS----PEKAKSPVKEEAKT------PEKA 736
Query: 478 QLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDES----EDEAAGP 533
+ P ++ K+P KA++LD + + K+ A S AD F +++ ++E P
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP 796
Query: 534 GVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGP------PKRLKASPPPSPAPSSSSSSS 587
A L D+ + E + P P+ +K PP A + ++
Sbjct: 797 ------EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT 850
Query: 588 SSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEK 647
T +K+ + P +E + E ++ + ++ K+E++E+K
Sbjct: 851 PKTEE----------KKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
Query: 648 GLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASAS 707
K + +K ++ E ++ P A+ P+ ++A
Sbjct: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP----AEKKEAAPEKKD 956
Query: 708 LLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGP 763
+ A+ E+ P A + + ++ P + P K ++S Q + P
Sbjct: 957 TKEEKAKKPEEKPKTEAKAKEDDKTLSKEP-----SKPKAEKAEKSSSTDQKDSKP 1007
Score = 62.8 bits (151), Expect = 2e-09
Identities = 96/482 (19%), Positives = 183/482 (37%), Gaps = 44/482 (9%)
Query: 301 PTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPA 360
P+ ++ K +++ +IK + KE + E +T+ET V +V + + AK
Sbjct: 430 PSVSTHIKVKSEEKIKVV-EKSEKETVIVE----EQTEETQVTEEVTEEEEKEAKEEEGK 484
Query: 361 QVQSSQDGGCPKEGKPKKKKTGAPPA-----PSCKDGAQGKDKTKDKGRGRPVEKPRADK 415
+ ++GG +E + +++T +PPA P + + K++ K + EK A
Sbjct: 485 E----EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 416 KGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPD--RPARRPSPTSGDSRPAAGRGP 473
S + K+ E K P + +P K + P + SP +++ A
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600
Query: 474 PRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGP 533
P + P ++ K+P+ E K+ +E S K ++A S +++EA P
Sbjct: 601 PEKAKSPVKEEAKSPA----EAKSPVKEEAKSPAEVKSPEKAKS-------PTKEEAKSP 649
Query: 534 GVPSVWPSALPSLSSDSDSDSDSSLGFPE-AQGPPKRLKASPPPSPAPSSSSSSSSSTSS 592
+ S + PE A+ P K SP + +P + S +
Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK 709
Query: 593 AGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRG-RLARQPPKEEKSEEKGLSG 651
+ + + EK S EE + VK E + A+ P K + + K
Sbjct: 710 SPVKEEAKSPEKA---KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEA 766
Query: 652 LTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPP--ARPPTAQEVCYLRAQQAQRASASLL 709
T P ++ S K ++ + P + P A+ P ++ +A + + +
Sbjct: 767 KT---PAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA---KAPEKEIPKKEEV 820
Query: 710 QAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQ 769
++P + EK V + P +K P A T K+ + P+P ++
Sbjct: 821 KSPVKEEEKPQEVKVKEPPKKAEEEKAP----ATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 770 LK 771
K
Sbjct: 877 KK 878
Score = 45.4 bits (106), Expect = 3e-04
Identities = 90/479 (18%), Positives = 177/479 (36%), Gaps = 55/479 (11%)
Query: 494 ERKARSLDEGASQDAPK---LKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDS 550
E K+ +E AS + +K+ A S A+ E E+ + P+ + S
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS--------PAEVKSPEKAK 551
Query: 551 DSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDS 610
+ + PEA+ P K SP +P + S + + + A+ K +
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA------KSPEKAK 605
Query: 611 DPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQG 670
P++E + E+ S E+ + P E KS EK S P ++ +K
Sbjct: 606 SPVKEEAKSPAEAKSPVKEEA-----KSPAEVKSPEKAKS------PTKEE-----AKSP 649
Query: 671 QEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEK 730
++ + P + A P + A+ A+ ++A S ++A A+ EK+ S + +
Sbjct: 650 EKAKSPEKEEAKSPEK---AKSPVKAEAKSPEKAK-SPVKAEAKSPEKAKSP-VKEEAKS 704
Query: 731 RRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKR 790
A P A +P AK + P ++ K+ + K T +
Sbjct: 705 PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP 764
Query: 791 IAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVA 850
A +P+ + + P +F K + +++ + E+ + +A EK + +++
Sbjct: 765 EAKTPAKEEARSPA--DKFPEKAKSPVKEEVKSP--EKAKSPLKEDAKAPEKEIPKKEEV 820
Query: 851 YDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSLS 910
+SP K V + + P KT ++ + K
Sbjct: 821 --KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD-----------SKKEEAPKK 867
Query: 911 RPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSS 969
P+VE+ K A+ + + + E+ P PE+ A + E+ +PK+ +
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT 926
Score = 41.6 bits (96), Expect = 0.005
Identities = 44/188 (23%), Positives = 73/188 (38%), Gaps = 39/188 (20%)
Query: 246 SRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTAS 305
S+ ++ A +P+ EP PK+ +A+ ++ED+ VP E
Sbjct: 859 SKKEEAPKKEAPKPKVEEKKEPAVEKPKE-----SKVEAKKEEAEDKKK-VPTPEK---- 908
Query: 306 TPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSS 365
+A A E+K +P K +V +P AK P++
Sbjct: 909 --EAPAKVEVKEDAKPKEKT-------------------EVAKKEPDDAKAKEPSKPAEK 947
Query: 366 QDGGCPKEGKPKKKKTGAPPA--PSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSP 423
KE P+KK T A P K + K K DK + KP+A+K +S+
Sbjct: 948 ------KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001
Query: 424 RRKAERPE 431
++ ++ PE
Sbjct: 1002 QKDSKPPE 1009
>gi|13569960 interferon stimulated exonuclease gene 20kDa-like 2 [Homo
sapiens]
Length = 353
Score = 67.8 bits (164), Expect = 6e-11
Identities = 51/156 (32%), Positives = 82/156 (52%), Gaps = 11/156 (7%)
Query: 1062 ALDCEMSYTT---YGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADT 1118
A+DCEM T + L R ++V+ + V+YD ++ P IVDY TR+SG+ + + +
Sbjct: 181 AIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDYRTRWSGIRKQHMVN- 239
Query: 1119 SVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIH--STVVDTSVLFP--HRLGLPYK 1174
+ + + +L + + I++GH++ +D AL+ H S DTS + P + P
Sbjct: 240 ATPFKIARGQILKILTG-KIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPEN 298
Query: 1175 --RSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHL 1208
SL++L L + IQ GHSS EDA A M L
Sbjct: 299 ATMSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMEL 334
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 67.4 bits (163), Expect = 8e-11
Identities = 183/892 (20%), Positives = 303/892 (33%), Gaps = 155/892 (17%)
Query: 37 RGSGAPGDGGEAPPAAGLGYDPYNPELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIE 96
+ + APG G+ P G P KP + E+ G E +A
Sbjct: 237 KAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE-----------EEAPA 285
Query: 97 AVRSEVELEQRRYRELLETTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSH 156
RS+V+ ++ +L+ R+A APA G A+P P A +A G
Sbjct: 286 GTRSQVKASEK----ILQV----RAASAPAKGTPGKGATPA--PPGKAGAVASQTKAGKP 335
Query: 157 GLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPV 216
S + + + + P +K L + G+ G A A PR+ + P
Sbjct: 336 EEDSESSSEESSD-SEEETPAAKALLQAKASGKTSQVGAASA-----PAKESPRKGAAPA 389
Query: 217 PSGKY--VVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKK 274
P GK V ++ E S+ + A ++ + + K P+ S P +P+K
Sbjct: 390 PPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 449
Query: 275 LCDPF--------------------GSCDARFSDSEDEAATVP--------GNEPTTAST 306
P + SDS+ EA G P
Sbjct: 450 GAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPA 509
Query: 307 PKARADPEIKATGQ-PPSKEGL---EAEGGGLRETKETAVQ--CDVGDLQPP----PAKP 356
P K G PP K G A+ G E E++ + D D + P PA+
Sbjct: 510 STMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 357 ASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCK--DGAQGKDKTKDKGRGR--PVEKPR 412
S + ++ P +G P+K A + K D ++ +++ D P
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 413 ADKKG----PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPA-RRPSPTSGDSRP 467
A K PQ + +K K P A G PA P+ G RP
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689
Query: 468 AAGRGPPRPLQLPDRKSTKAPS-------GKLVERKARS------LDEGASQDAP----- 509
A + K+ A + GK ++ KA S L +G + P
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP 749
Query: 510 -----KLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQ 564
K +K+ S + +SE+ AA P + ++ + + + S+ G A
Sbjct: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 809
Query: 565 G------------------PPKR------LKASPPPSPAPSSSSSSSSSTSSAGADVDYS 600
G PP R + A P S + ++++ + G + D
Sbjct: 810 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG 869
Query: 601 ALEKEVDFDSDPMEECLRIFNESTSVKTED-RGRLA---RQPPKEEKSEEKGLSGLTTLF 656
+ E+E SD EE + S KT R LA P K G +G +
Sbjct: 870 SSEEE----SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 657 PGQKRRISHLSKQG-------------QEVEPP------RRGPAVPPARPPTAQEVCYLR 697
G++ S++ Q ++PP R PA P A P AQ R
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 698 AQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIP--NPRLAAAPTGAKRTLAAS 755
+A ++A + + + P+ PG + + +P +PR+A + A + +
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKE 1045
Query: 756 GSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPK 807
S+ S+G + G + + G T+ + L+KP +P+
Sbjct: 1046 SSRISDGKKQEGPATQVDSAVGTLPATSP---QSTSVQAKGTNKLRKPKLPE 1094
Score = 53.5 bits (127), Expect = 1e-06
Identities = 184/869 (21%), Positives = 280/869 (32%), Gaps = 147/869 (16%)
Query: 35 GARGSGA----PGDGGEAPPAAGLGY-------------DPYNPELPKPPAQRENGTLGL 77
G G GA PG G A P+A +G D + E+P A + +LG
Sbjct: 515 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGN 574
Query: 78 GEEPRPDVLELELVNQAIEAVRSEVELEQR--RYRELLETTREHRSAEAPALAPRGPNAS 135
+ +P + Q V +V+ E+ E++ S EAPA A A
Sbjct: 575 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA-AMTAAQAK 633
Query: 136 PTVG-PDEDAFPLAFD--------------YSPGSHGLLSPDAGYQPTPLAA---PAEPG 177
P + P A P + +P G + AG P PAE
Sbjct: 634 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
Query: 178 SKYSLASLDR---------GQGRGGGGGGALEYVPKAVSQPRRHS-----RPVPSGKYVV 223
S + + GQ + G G + KA S P + S PV GK
Sbjct: 694 SSSEESDSEEEKTGLAVTVGQAKSVGKGLQV----KAASVPVKGSLGQGTAPVLPGKTGP 749
Query: 224 DNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCD 283
++ + + D S S S E AA P + S T A
Sbjct: 750 TVTQVKAEKQEDSES-------SEEESDSEEAAASPAQVKTSVKKTQAKANPA------- 795
Query: 284 ARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKE 339
A + S + PG T A+ K R+ ++K + P + A G + +
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 340 TAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKK---------------KTGAP 384
TA Q G P +S + S ++ + KP K + GA
Sbjct: 856 TAAQAQTG---PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 385 PAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAE----------RPEGTK 434
P P K G K G E+ +D + P A + + + P G
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPA 972
Query: 435 KKPSSATPVATSGKGRPDRPARRPSPTSGDSR---PAAGRGPP----RPLQLPDRKSTKA 487
P+ A +T K R R S + + PA P + +P A
Sbjct: 973 ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 488 PSGKLV----ERKARSLDEGASQDAPKLK-KRALSHADLFGDESED-EAAG------PGV 535
P + +++ + +G Q+ P + A+ +S +A G P +
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 536 PSVWPSA-LPSLSSDSDSDSDSSLGFPE-AQGPPKRLKASPPPSPAPSSSSSSSSSTSSA 593
P V + P S DS+ SDSS G E +GP A P PS + + T++
Sbjct: 1093 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAE 1152
Query: 594 GADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTED-------RGRLARQPPKEEKSEE 646
++ D A + + S M L N S T LA + + K E
Sbjct: 1153 SSEDDVVAPSQSL--LSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEA 1210
Query: 647 KGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQE---VCYLRAQ---Q 700
K L P + + Q+ P++G P A Q C L
Sbjct: 1211 KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLN 1270
Query: 701 AQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTL-------- 752
+ AS+++ L E+ + E R R + A RT
Sbjct: 1271 EAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKL 1330
Query: 753 -AASGSQSSNGPEPGGQQLKTRTLSGMAS 780
A G ++S PE K + AS
Sbjct: 1331 GAGEGGEASVSPEKTSTTSKGKAKRDKAS 1359
Score = 47.8 bits (112), Expect = 7e-05
Identities = 116/528 (21%), Positives = 177/528 (33%), Gaps = 105/528 (19%)
Query: 244 HLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTT 303
HL RA RAA+ + G + + P L D + + + + E
Sbjct: 17 HLLRAGY--VRAAREVKEQSGQKCFLAQPVTLLDIY----THWQQTSELGRKRKAEEDAA 70
Query: 304 ASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKETAVQCDVGDLQPPPAKPASP 359
K R I + +E EAE L T + + D+ AK +
Sbjct: 71 LQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETE 130
Query: 360 AQVQSSQDGGCPKEGKPKKKK-TGAPPAPSCKDGAQGK--DKTKDKGR-------GRP-- 407
++ P GK +G P S + A +T+++G +P
Sbjct: 131 KAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
Query: 408 VEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRP 467
V +AD SS + + KP+ + S K P R A GD P
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP 250
Query: 468 AAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESE 527
G LP K K P E ++ S +EG+ ESE
Sbjct: 251 QVKGG-----ALPPAKRAKKP-----EEESESSEEGS--------------------ESE 280
Query: 528 DEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSS 587
+EA P+ S S+ A+G P + +PAP + +
Sbjct: 281 EEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGK-----GATPAPPGKAGAV 326
Query: 588 SSTSSAGADVDYSALEKEVDFDSDPMEECLR-IFNESTSVKTEDRGRLARQPPKEEKSEE 646
+S + AG + S E DS+ + + S KT G A P KE S
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG-AASAPAKE--SPR 383
Query: 647 KGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASA 706
KG + P + GPAV A+ +E +Q + S
Sbjct: 384 KGAA---------------------PAPPGKTGPAVAKAQAGKREE----DSQSSSEESD 418
Query: 707 SLLQAPARL--AEKSPSVH-ISAPGEKRRIAHIPNPRLAAAPTGAKRT 751
S +APA+ + K+P V SAP ++ +PR AAP ++T
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKE-------SPRKGAAPAPPRKT 459
Score = 42.7 bits (99), Expect = 0.002
Identities = 92/453 (20%), Positives = 159/453 (35%), Gaps = 86/453 (18%)
Query: 115 TTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPG--SHGLLSPDAGYQPTPLAA 172
T R+ R++E+ A +S + DED P +PG ++ + P A + P A+
Sbjct: 983 TPRKARASESTA------RSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKAS 1036
Query: 173 PAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDL 232
A S + + G+ + G V + + + G + + P
Sbjct: 1037 MAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQ 1096
Query: 233 EYD--PLSNYSARHLSRASSRDERAAKRPRGSRGSEPYT-PAPKKLCDPFGSCDARFSDS 289
+ P S+ + S +SS E + P+G++ + P P + A S+
Sbjct: 1097 QATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSED 1156
Query: 290 EDEAAT------------VPGNEPTTASTPKARADPEIKAT------------------- 318
+ A + P N + +TPK + P + +T
Sbjct: 1157 DVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAA 1216
Query: 319 --------------GQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQS 364
G P K +G G + A+Q ++ P + AQVQ+
Sbjct: 1217 GMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQA 1276
Query: 365 SQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGR-GRPVEKPRADKKGPQASSP 423
S + + ++KK D TK+ R G K + P A +P
Sbjct: 1277 SVVKVLTELLEQERKKV--------------VDTTKESSRKGWESRKRKLSGDQPAARTP 1322
Query: 424 RRKAERPEGT-KKKPSSATP--VATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLP 480
R K ++ G + +S +P +T+ KG+ R SGD + G+G L
Sbjct: 1323 RSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKR-----DKASGDVKEKKGKG-----SLG 1372
Query: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPKLKK 513
+ + P +L +K EG Q PK KK
Sbjct: 1373 SQGAKDEPEEEL--QKGMGTVEGGDQSNPKSKK 1403
Score = 35.8 bits (81), Expect = 0.26
Identities = 79/385 (20%), Positives = 140/385 (36%), Gaps = 53/385 (13%)
Query: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPK-LKKRALSH---ADLFGDESEDEAAGPGVP 536
+ + +A + K R A + D P +K++A + A G+ A G V
Sbjct: 90 EEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVA 149
Query: 537 SVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGAD 596
++ P S++ +++ E P A+ P + + SSS TSS+
Sbjct: 150 NLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS--- 206
Query: 597 VDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPK--EEKSEEKGLSGLTT 654
E D + P + ++ S S K + A P K + + KG +
Sbjct: 207 ------SDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPA 260
Query: 655 LFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPAR 714
+ S S++G E E PA ++ ++++ +RA ASA P +
Sbjct: 261 KRAKKPEEESESSEEGSESE--EEAPAGTRSQVKASEKILQVRA-----ASAPAKGTPGK 313
Query: 715 LAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPE---PGGQQLK 771
A +P PG+ +A + G + S S+ S+ E P + L
Sbjct: 314 GATPAP------PGKAGAVA-------SQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 772 TRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLK 831
SG S+ A +P+ +S +K P G P V + + K
Sbjct: 361 QAKASGKTSQVGA-------ASAPAKESPRKGAAPAPPGKTGPAVAK--------AQAGK 405
Query: 832 FCTSNQEAIEKALNEEKVAYDRSPS 856
+Q + E++ +EE+ PS
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPS 430
Score = 32.3 bits (72), Expect = 2.8
Identities = 48/191 (25%), Positives = 70/191 (36%), Gaps = 51/191 (26%)
Query: 258 RPRGSRGSEPY--TPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEI 315
R R G +P TP KK + E A+V + +T S KA+ D
Sbjct: 1308 RKRKLSGDQPAARTPRSKK--------KKKLGAGEGGEASVSPEKTSTTSKGKAKRD--- 1356
Query: 316 KATGQPPSKEGLEAEGG-GLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEG 374
KA+G K+G + G G ++ E +Q +G ++ GG +
Sbjct: 1357 KASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVE-----------------GG--DQS 1397
Query: 375 KPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTK 434
PK KK +K K R + EK KK +AS+ + +E P K
Sbjct: 1398 NPKSKK----------------EKKKSDKRKKDKEKKEKKKKAKKAST--KDSESPSQKK 1439
Query: 435 KKPSSATPVAT 445
KK T T
Sbjct: 1440 KKKKKKTAEQT 1450
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 67.4 bits (163), Expect = 8e-11
Identities = 183/892 (20%), Positives = 303/892 (33%), Gaps = 155/892 (17%)
Query: 37 RGSGAPGDGGEAPPAAGLGYDPYNPELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIE 96
+ + APG G+ P G P KP + E+ G E +A
Sbjct: 237 KAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE-----------EEAPA 285
Query: 97 AVRSEVELEQRRYRELLETTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSH 156
RS+V+ ++ +L+ R+A APA G A+P P A +A G
Sbjct: 286 GTRSQVKASEK----ILQV----RAASAPAKGTPGKGATPA--PPGKAGAVASQTKAGKP 335
Query: 157 GLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPV 216
S + + + + P +K L + G+ G A A PR+ + P
Sbjct: 336 EEDSESSSEESSD-SEEETPAAKALLQAKASGKTSQVGAASA-----PAKESPRKGAAPA 389
Query: 217 PSGKY--VVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKK 274
P GK V ++ E S+ + A ++ + + K P+ S P +P+K
Sbjct: 390 PPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 449
Query: 275 LCDPF--------------------GSCDARFSDSEDEAATVP--------GNEPTTAST 306
P + SDS+ EA G P
Sbjct: 450 GAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPA 509
Query: 307 PKARADPEIKATGQ-PPSKEGL---EAEGGGLRETKETAVQ--CDVGDLQPP----PAKP 356
P K G PP K G A+ G E E++ + D D + P PA+
Sbjct: 510 STMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 357 ASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCK--DGAQGKDKTKDKGRGR--PVEKPR 412
S + ++ P +G P+K A + K D ++ +++ D P
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 413 ADKKG----PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPA-RRPSPTSGDSRP 467
A K PQ + +K K P A G PA P+ G RP
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689
Query: 468 AAGRGPPRPLQLPDRKSTKAPS-------GKLVERKARS------LDEGASQDAP----- 509
A + K+ A + GK ++ KA S L +G + P
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP 749
Query: 510 -----KLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQ 564
K +K+ S + +SE+ AA P + ++ + + + S+ G A
Sbjct: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 809
Query: 565 G------------------PPKR------LKASPPPSPAPSSSSSSSSSTSSAGADVDYS 600
G PP R + A P S + ++++ + G + D
Sbjct: 810 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG 869
Query: 601 ALEKEVDFDSDPMEECLRIFNESTSVKTED-RGRLA---RQPPKEEKSEEKGLSGLTTLF 656
+ E+E SD EE + S KT R LA P K G +G +
Sbjct: 870 SSEEE----SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 657 PGQKRRISHLSKQG-------------QEVEPP------RRGPAVPPARPPTAQEVCYLR 697
G++ S++ Q ++PP R PA P A P AQ R
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 698 AQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIP--NPRLAAAPTGAKRTLAAS 755
+A ++A + + + P+ PG + + +P +PR+A + A + +
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKE 1045
Query: 756 GSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPK 807
S+ S+G + G + + G T+ + L+KP +P+
Sbjct: 1046 SSRISDGKKQEGPATQVDSAVGTLPATSP---QSTSVQAKGTNKLRKPKLPE 1094
Score = 55.1 bits (131), Expect = 4e-07
Identities = 183/868 (21%), Positives = 281/868 (32%), Gaps = 146/868 (16%)
Query: 35 GARGSGA----PGDGGEAPPAAGLGY-------------DPYNPELPKPPAQRENGTLGL 77
G G GA PG G A P+A +G D + E+P A + +LG
Sbjct: 515 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGN 574
Query: 78 GEEPRPDVLELELVNQAIEAVRSEVELEQR--RYRELLETTREHRSAEAPALAPRGPNAS 135
+ +P + Q V +V+ E+ E++ S EAPA A A
Sbjct: 575 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA-AMTAAQAK 633
Query: 136 PTVG-PDEDAFPLAFD--------------YSPGSHGLLSPDAGYQPTPLAA---PAEPG 177
P + P A P + +P G + AG P PAE
Sbjct: 634 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
Query: 178 SKYSLASLDR---------GQGRGGGGGGALEYVPKAVSQPRRHS-----RPVPSGKYVV 223
S + + GQ + G G + KA S P + S PV GK
Sbjct: 694 SSSEESDSEEEKTGLAVTVGQAKSVGKGLQV----KAASVPVKGSLGQGTAPVLPGKTGP 749
Query: 224 DNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCD 283
++ + + D S S S E AA P + S T A
Sbjct: 750 TVTQVKAEKQEDSES-------SEEESDSEEAAASPAQVKTSVKKTQAKANPA------- 795
Query: 284 ARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKE 339
A + S + PG T A+ K R+ ++K + P + A G + +
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 340 TAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKK---------------KTGAP 384
TA Q G P +S + S ++ + KP K + GA
Sbjct: 856 TAAQAQTG---PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 385 PAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAE----------RPEGTK 434
P P K G K G E+ +D + P A + + + P G
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPA 972
Query: 435 KKPSSATPVATSGKGRPDRPARRPSPTSGDSR---PAAGRGPP----RPLQLPDRKSTKA 487
P+ A +T K R R S + + PA P + +P A
Sbjct: 973 ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 488 PSGKLV----ERKARSLDEGASQDAPKLK-KRALSHADLFGDESED-EAAG------PGV 535
P + +++ + +G Q+ P + A+ +S +A G P +
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 536 PSVWPSA-LPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAG 594
P V + P S DS+ SDSS G E P+ K++ P PS + + T++
Sbjct: 1093 PEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAES 1152
Query: 595 ADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTED-------RGRLARQPPKEEKSEEK 647
++ D A + + S M L N S T LA + + K E K
Sbjct: 1153 SEDDVVAPSQSL--LSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAK 1210
Query: 648 GLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQE---VCYLRAQ---QA 701
L P + + Q+ P++G P A Q C L
Sbjct: 1211 PQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNE 1270
Query: 702 QRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTL--------- 752
+ AS+++ L E+ + E R R + A RT
Sbjct: 1271 AQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLG 1330
Query: 753 AASGSQSSNGPEPGGQQLKTRTLSGMAS 780
A G ++S PE K + AS
Sbjct: 1331 AGEGGEASVSPEKTSTTSKGKAKRDKAS 1358
Score = 47.8 bits (112), Expect = 7e-05
Identities = 116/528 (21%), Positives = 177/528 (33%), Gaps = 105/528 (19%)
Query: 244 HLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTT 303
HL RA RAA+ + G + + P L D + + + + E
Sbjct: 17 HLLRAGY--VRAAREVKEQSGQKCFLAQPVTLLDIY----THWQQTSELGRKRKAEEDAA 70
Query: 304 ASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKETAVQCDVGDLQPPPAKPASP 359
K R I + +E EAE L T + + D+ AK +
Sbjct: 71 LQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETE 130
Query: 360 AQVQSSQDGGCPKEGKPKKKK-TGAPPAPSCKDGAQGK--DKTKDKGR-------GRP-- 407
++ P GK +G P S + A +T+++G +P
Sbjct: 131 KAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
Query: 408 VEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRP 467
V +AD SS + + KP+ + S K P R A GD P
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP 250
Query: 468 AAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESE 527
G LP K K P E ++ S +EG+ ESE
Sbjct: 251 QVKGG-----ALPPAKRAKKP-----EEESESSEEGS--------------------ESE 280
Query: 528 DEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSS 587
+EA P+ S S+ A+G P + +PAP + +
Sbjct: 281 EEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGK-----GATPAPPGKAGAV 326
Query: 588 SSTSSAGADVDYSALEKEVDFDSDPMEECLR-IFNESTSVKTEDRGRLARQPPKEEKSEE 646
+S + AG + S E DS+ + + S KT G A P KE S
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG-AASAPAKE--SPR 383
Query: 647 KGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASA 706
KG + P + GPAV A+ +E +Q + S
Sbjct: 384 KGAA---------------------PAPPGKTGPAVAKAQAGKREE----DSQSSSEESD 418
Query: 707 SLLQAPARL--AEKSPSVH-ISAPGEKRRIAHIPNPRLAAAPTGAKRT 751
S +APA+ + K+P V SAP ++ +PR AAP ++T
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKE-------SPRKGAAPAPPRKT 459
Score = 35.8 bits (81), Expect = 0.26
Identities = 79/385 (20%), Positives = 140/385 (36%), Gaps = 53/385 (13%)
Query: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPK-LKKRALSH---ADLFGDESEDEAAGPGVP 536
+ + +A + K R A + D P +K++A + A G+ A G V
Sbjct: 90 EEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVA 149
Query: 537 SVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGAD 596
++ P S++ +++ E P A+ P + + SSS TSS+
Sbjct: 150 NLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS--- 206
Query: 597 VDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPK--EEKSEEKGLSGLTT 654
E D + P + ++ S S K + A P K + + KG +
Sbjct: 207 ------SDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPA 260
Query: 655 LFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPAR 714
+ S S++G E E PA ++ ++++ +RA ASA P +
Sbjct: 261 KRAKKPEEESESSEEGSESE--EEAPAGTRSQVKASEKILQVRA-----ASAPAKGTPGK 313
Query: 715 LAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPE---PGGQQLK 771
A +P PG+ +A + G + S S+ S+ E P + L
Sbjct: 314 GATPAP------PGKAGAVA-------SQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 772 TRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLK 831
SG S+ A +P+ +S +K P G P V + + K
Sbjct: 361 QAKASGKTSQVGA-------ASAPAKESPRKGAAPAPPGKTGPAVAK--------AQAGK 405
Query: 832 FCTSNQEAIEKALNEEKVAYDRSPS 856
+Q + E++ +EE+ PS
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPS 430
Score = 32.3 bits (72), Expect = 2.8
Identities = 48/191 (25%), Positives = 70/191 (36%), Gaps = 51/191 (26%)
Query: 258 RPRGSRGSEPY--TPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEI 315
R R G +P TP KK + E A+V + +T S KA+ D
Sbjct: 1307 RKRKLSGDQPAARTPRSKK--------KKKLGAGEGGEASVSPEKTSTTSKGKAKRD--- 1355
Query: 316 KATGQPPSKEGLEAEGG-GLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEG 374
KA+G K+G + G G ++ E +Q +G ++ GG +
Sbjct: 1356 KASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVE-----------------GG--DQS 1396
Query: 375 KPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTK 434
PK KK +K K R + EK KK +AS+ + +E P K
Sbjct: 1397 NPKSKK----------------EKKKSDKRKKDKEKKEKKKKAKKAST--KDSESPSQKK 1438
Query: 435 KKPSSATPVAT 445
KK T T
Sbjct: 1439 KKKKKKTAEQT 1449
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 67.4 bits (163), Expect = 8e-11
Identities = 112/506 (22%), Positives = 173/506 (34%), Gaps = 83/506 (16%)
Query: 351 PPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEK 410
P P KP S + SS PK+ K KKKK + S + K +K K E
Sbjct: 165 PEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESES 224
Query: 411 PRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPA--------------- 455
+ + P +P+ K + + +K+ S TP S + A
Sbjct: 225 KKRKHRSP---TPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRS 281
Query: 456 ------------RRPSPTSGDSRPAAGRGP-----PRPLQLPD--RKSTKAPSGKLVERK 496
R PSP SG R G P Q P +TK PS ++
Sbjct: 282 AAAKTHTTALAGRSPSPASG--RRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKD 339
Query: 497 ARSLDEGASQDAPKLKKRALSH---------ADLFGDE---------SEDEAAGPGVPSV 538
++ A++ +P ++ + A+ G S++ P S
Sbjct: 340 KDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASP 399
Query: 539 WPSALPSLSSDSDSDSDSSLGFPEAQGPPK--RLKASPP--PSPAPSSSSSSSSSTSSAG 594
P S + S SS P + P K R +S P P PAP+ S S+S
Sbjct: 400 TRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTS 459
Query: 595 ADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGR-LARQPPKEEKSEEKGLSGLT 653
+ + +++ P R S S T RGR +R P K S +
Sbjct: 460 KNRSHGRAKRDKSHSHTPS----RRMGRSRSPATAKRGRSRSRTPTKRGHSRSRS----- 510
Query: 654 TLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPA 713
Q RR + G+ P RRG + P RP + R++ QR S
Sbjct: 511 ----PQWRRSRSAQRWGRSRSPQRRGRSRSPQRPG------WSRSRNTQRRGRSRSARRG 560
Query: 714 RLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTR 773
R +SP+ + R A RT S+S G + ++R
Sbjct: 561 RSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRG--RSRSR 618
Query: 774 TLSGMASKTTTTIIPKRIAHSPSLQS 799
T + S+T + + + + SP+ +S
Sbjct: 619 TPARRRSRTRSPVRRRSRSRSPARRS 644
Score = 53.5 bits (127), Expect = 1e-06
Identities = 151/737 (20%), Positives = 245/737 (33%), Gaps = 91/737 (12%)
Query: 114 ETTREH-RSAEAP----ALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPT 168
+T+R RSA A ALA R P+ + + DA P + PG+ P +
Sbjct: 273 DTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDA-PFS---EPGTTSTQRPSS----- 323
Query: 169 PLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRP 228
P A +P S Y D+ + A P P P+ +
Sbjct: 324 PETATKQPSSPYEDKDKDKKEK------SATRPSPSPERSSTGPEPPAPTPLLAERHGGS 377
Query: 229 PTDLEYDPLSNYSARHLSRAS-SRDERAAKRPR-----GSRGSEPYTPAPKKLCDPFGSC 282
P L PLS S AS +RD K P S S P +P P K+ S
Sbjct: 378 PQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKV-----SR 432
Query: 283 DARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAV 342
A S + A PG+ +S+P ++ +A + S + G + TA
Sbjct: 433 HASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAK-RDKSHSHTPSRRMGRSRSPATAK 491
Query: 343 QCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDK 402
+ P + Q + + G+ + + + G T+ +
Sbjct: 492 RGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRR 551
Query: 403 GRGRPVEKPRADKKGPQA------------------SSPRRKAERPEGTKKKPSSATPVA 444
GR R + R+ + P + RR++ T+++ S TP A
Sbjct: 552 GRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTP-A 610
Query: 445 TSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGA 504
G+ R PARR S T R + P R T A G+ R
Sbjct: 611 RRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSR 670
Query: 505 SQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWP--------SALPSLSSDSDSDSDS 556
S+ + R+ S S G S P S S S+
Sbjct: 671 SRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSER 730
Query: 557 SLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSD-PMEE 615
+Q R +SP + SS S S +S +L + + S P ++
Sbjct: 731 KNKSRTSQ-RRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQK 789
Query: 616 CLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEP 675
S S ++ + + +R PP+ +S P K++ S+Q
Sbjct: 790 SQTPPRRSRSGSSQPKAK-SRTPPRRSRSSSS---------PPPKQKSKTPSRQSHSSSS 839
Query: 676 PRRGPAVPPARPPTAQEVCYLRAQQ----AQRASASLLQAPARLAEKSPSVHISAPGEKR 731
P P V PP + +A + QR S L ++PS H +
Sbjct: 840 PH--PKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPP 897
Query: 732 RI------------AHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMA 779
R+ + P P++ A + +R+ + S S S + ++R++S
Sbjct: 898 RVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVS-PC 956
Query: 780 SKTTTTIIPKRIAHSPS 796
S + ++P R +HS S
Sbjct: 957 SNVESRLLP-RYSHSGS 972
Score = 52.0 bits (123), Expect = 3e-06
Identities = 146/652 (22%), Positives = 218/652 (33%), Gaps = 100/652 (15%)
Query: 184 SLD-RGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSA 242
SLD + Q G + E P AV + S S + R P+ S+
Sbjct: 1368 SLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEM 1427
Query: 243 RH-LSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNE- 300
+ L R SR R+ P GS TP+ L + + PG +
Sbjct: 1428 KDGLPRTPSRRSRSGSSPGLRDGSG--TPSRHSL-----------------SGSSPGMKD 1468
Query: 301 -PTTASTPKARAD--PEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPA 357
P T S ++ D PE KA Q P L T + G K
Sbjct: 1469 IPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTV 1528
Query: 358 SPAQVQSSQDGGCPKE--GKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADK 415
+ + G +E KP + S D ++ K +T + R R P D
Sbjct: 1529 ARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPD-SKAKTRTPLRQRSRSGSSPEVDS 1587
Query: 416 KGPQASSPRRKAERPEGTKKKPSSATPVATSGKG---RPDRPARRPSPTSGDSRPAA-GR 471
K + R PE K KP +A P A SG P PA R P S ++ GR
Sbjct: 1588 KSRLSPRRSRSGSSPE-VKDKPRAA-PRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGR 1645
Query: 472 GP-PRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEA 530
GP P + P + R +RS E PK K R
Sbjct: 1646 GPSPEGSSSTESSPEHPPKSRTARRGSRSSPE------PKTKSRTPPR----------RR 1689
Query: 531 AGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSST 590
+ P + A S S S S S + ++ PP+ ++ SP P+ S SS
Sbjct: 1690 SSRSSPELTRKARLSRRSRSASSSPET----RSRTPPRHRRSPSVSSPEPAEKSRSSRRR 1745
Query: 591 SSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTE--DRGRLARQPPKEEKSEEKG 648
SA S P + S S K R R + K + +
Sbjct: 1746 RSA----------------SSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRD 1789
Query: 649 LSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASL 708
SG + +++R S+ V RRG + +R P QE ++ + R
Sbjct: 1790 RSGSSQSTSRRRQR----SRSRSRVTRRRRGGSGYHSRSPARQE----SSRTSSRRRRGR 1841
Query: 709 LQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQ 768
+ P ++S S AP ++ R P A RT S +S +
Sbjct: 1842 SRTPPTSRKRSRSRTSPAPWKRSRSRASP----ATHRRSRSRTPLISRRRSRS------- 1890
Query: 769 QLKTRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQR 820
+T +S S++ T++ +R +S P+ + + P V R+R
Sbjct: 1891 --RTSPVSRRRSRSRTSVTRRR------SRSRASPVSRRRSRSRTPPVTRRR 1934
Score = 46.2 bits (108), Expect = 2e-04
Identities = 103/516 (19%), Positives = 179/516 (34%), Gaps = 57/516 (11%)
Query: 289 SEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGD 348
++ T P A TP A A + +G PP+ + T + ++
Sbjct: 2285 ADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSS----RTPQAPASANL-- 2338
Query: 349 LQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPV 408
+ P A +P + S +T A AP+ A+ G +
Sbjct: 2339 VGPRSAHATAPVNIAGS--------------RTAAALAPASLTSARMAPALS----GANL 2380
Query: 409 EKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPA 468
PR P ++ R + S TP + + R R PSP+S
Sbjct: 2381 TSPRV----PLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRM-TSERAPSPSS-----R 2430
Query: 469 AGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESED 528
G+ P + L P + ++P ++R L +Q P ++LS + S
Sbjct: 2431 MGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCL---IAQTTPVAGSQSLSSGAVATTTSSA 2487
Query: 529 -------EAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPS 581
PGVP S + + + + S+L A P K ++S S + S
Sbjct: 2488 GDHNGMLSVPAPGVPH---SDVGEPPASTGAQQPSALA---ALQPAKERRSSSSSSSSSS 2541
Query: 582 SSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDR-GRLARQPPK 640
SSSSSSSS+SS+ + S+ + P R+ + + + K R GR P
Sbjct: 2542 SSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPA 2601
Query: 641 EEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQ 700
+ K S ++ S S + + P+ + Q
Sbjct: 2602 KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP---GPQA 2658
Query: 701 AQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSS 760
+ ++ P +SP I + + R +++ P R +P + R +S S+
Sbjct: 2659 LPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERG 2718
Query: 761 NGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPS 796
+ GQ+ +R+ S + T + P R S S
Sbjct: 2719 S---RRGQRGDSRSPSHKRRRETPSPRPMRHRSSRS 2751
Score = 43.5 bits (101), Expect = 0.001
Identities = 94/471 (19%), Positives = 163/471 (34%), Gaps = 56/471 (11%)
Query: 153 PGSHGLLSPDAGYQPTPLAAPAEPGSKYSLA--SLDRGQGRGGGGGGALEYVPKAVSQPR 210
P G S ++ + P + A GS+ S + R R + E KA +
Sbjct: 1647 PSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKA--RLS 1704
Query: 211 RHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEP-YT 269
R SR S + PP +S+ SR SSR R+A PR S +
Sbjct: 1705 RRSRSASSSPETRSRT-PPRHRRSPSVSSPEPAEKSR-SSRRRRSASSPRTKTTSRRGRS 1762
Query: 270 PAPKKLCDPFGSCDARFSDSEDEAATVPGNEPT----TASTPKARADPEIKATGQPPSKE 325
P+PK P G +R ++ T + + + S + R+ + T +
Sbjct: 1763 PSPK----PRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGS 1818
Query: 326 GLEAEGGGLRETKETAVQCDVGDLQPPPAKP------ASPAQVQSSQDGGCPKEGKPKKK 379
G + +E+ T+ + G + PP SPA + S+ P + +
Sbjct: 1819 GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRS 1878
Query: 380 KTG-----------APPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAE 428
+T +P + + + + R PV + R+ + P + RR
Sbjct: 1879 RTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTR-RRSRS 1937
Query: 429 RPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAP 488
R T+++ S TP T + R P + + P R R+ +++
Sbjct: 1938 RTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSR 1997
Query: 489 SGKLVERKARSLD------EGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSA 542
+ + R++RS S+ P +++R+ S L + + P A
Sbjct: 1998 TSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRS--------PLA 2049
Query: 543 LPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSA 593
+ S P + L SPP S+S SSS + SA
Sbjct: 2050 IRRRSRSRT---------PRTARGKRSLTRSPPAIRRRSASGSSSDRSRSA 2091
Score = 42.4 bits (98), Expect = 0.003
Identities = 82/395 (20%), Positives = 135/395 (34%), Gaps = 49/395 (12%)
Query: 435 KKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGR--GP-----PRPLQLPDRKSTKA 487
+ P++ ++ +G G P A PS + PA+ GP P+ + ++ A
Sbjct: 2301 RTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAA 2360
Query: 488 --PSGKLVERKARSLDEGASQDAPKLKKRALSHAD-------LFGDESEDEAAGPGVPSV 538
P+ R A +L GA+ +P++ A L S + P +
Sbjct: 2361 LAPASLTSARMAPALS-GANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRM 2419
Query: 539 WPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSS-----SSTSSA 593
PS SS SL P AQ P+ SP PS+ S S +T A
Sbjct: 2420 TSERAPSPSSRMGQAPSQSL-LPPAQDQPR--------SPVPSAFSDQSRCLIAQTTPVA 2470
Query: 594 GADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLT 653
G+ S + L + + V D G +PP +++ S L
Sbjct: 2471 GSQSLSSGAVATTTSSAGDHNGMLSV--PAPGVPHSDVG----EPPASTGAQQP--SALA 2522
Query: 654 TLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPA 713
L P ++RR S S + ++ + + S L
Sbjct: 2523 ALQPAKERRSSSSSSSSSSSS----------SSSSSSSSSSSSSGSSSSDSEGSSLPVQP 2572
Query: 714 RLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTR 773
+A K AP E R P P A + + ++S S SS+ +
Sbjct: 2573 EVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSS 2632
Query: 774 TLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKE 808
+ S +S ++++ P Q+L KP PK+
Sbjct: 2633 SSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKK 2667
Score = 38.5 bits (88), Expect = 0.040
Identities = 76/376 (20%), Positives = 131/376 (34%), Gaps = 29/376 (7%)
Query: 425 RKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGD-SRPAAGRGPPRPLQLPDRK 483
R+A++P KP S V S R P ++ D R + P R + +K
Sbjct: 158 REAKQPAPEPPKPYSL--VRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKK 215
Query: 484 STKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSAL 543
+ +RK RS S+ K KKR S + +S A
Sbjct: 216 KKHRSESESKKRKHRS-PTPKSKRKSKDKKRKRSRSTTPAPKSR-------------RAH 261
Query: 544 PSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALE 603
S S+DS S SD+S + A SP+P+S D +S E
Sbjct: 262 RSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGE-------GDAPFS--E 312
Query: 604 KEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRI 663
P S+ + +D+ + + + S E+ +G P
Sbjct: 313 PGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAE 372
Query: 664 SH-LSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSV 722
H S Q P + P PP+ ++ ++ + S+S +P S
Sbjct: 373 RHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSR 432
Query: 723 HISAPGEKRRIAHIP--NPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMAS 780
H S+ E + A P + ++++PT R+ + S+ P + ++R+ +
Sbjct: 433 HASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKR 492
Query: 781 KTTTTIIPKRIAHSPS 796
+ + P + HS S
Sbjct: 493 GRSRSRTPTKRGHSRS 508
Score = 34.7 bits (78), Expect = 0.57
Identities = 107/528 (20%), Positives = 186/528 (35%), Gaps = 84/528 (15%)
Query: 246 SRASSRDERAAKR--PRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTT 303
SR+ S +A R PR SR S P K S + + ++ T P T
Sbjct: 797 SRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSIT 856
Query: 304 AS-------TPKARA------DPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQ 350
+ TP+ R+ DPE+K+ + PS+ ++ Q
Sbjct: 857 SPQANEQSVTPQRRSCFESSPDPELKS--RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSS 914
Query: 351 PPPAKPASPAQVQSSQDGGC-PKEGK------PKKKKTGAPPA-------PSCKDGAQGK 396
P P A + Q S G P + P++ ++ +P + P
Sbjct: 915 PQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSS 974
Query: 397 DKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPAR 456
TK K P PR G + P+ KA+ P G + SG ++
Sbjct: 975 PDTKVK----PETPPRQSHSGSISPYPKVKAQTPPGP----------SLSG-------SK 1013
Query: 457 RPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSG---------KLVERKARSLDEGASQD 507
P P S+ + + P L L + P G +L + S D +
Sbjct: 1014 SPCPQE-KSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTS 1072
Query: 508 APKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPP 567
+P++++ SH++ +S+ + + G S S + L+S S D
Sbjct: 1073 SPEVRQ---SHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRG---------- 1119
Query: 568 KRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVK 627
ASP S S S SS+ VD ++L + ++ +E + + + +
Sbjct: 1120 -EFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATA 1178
Query: 628 TEDRGRLARQP-PKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPAR 686
+ R + P P +++ E + T P ++R S G E + A+P +
Sbjct: 1179 SPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRER-----SGAGSSPETKEQNSALPTSS 1233
Query: 687 PPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIA 734
+E+ + + + A L + L E S S S+P + R A
Sbjct: 1234 QD--EELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPA 1279
Score = 31.2 bits (69), Expect = 6.3
Identities = 47/217 (21%), Positives = 72/217 (33%), Gaps = 15/217 (6%)
Query: 171 AAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPT 230
++ + S S +S G G +L P+ +R P P+ K V RPP
Sbjct: 2540 SSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVAL--KRVPSPTPAPKEAVREGRPP- 2596
Query: 231 DLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSE 290
E P A+ R+SS ++ S S + + S + S S
Sbjct: 2597 --EPTP-----AKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP 2649
Query: 291 DEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQ 350
A P P AS PK E ++ + L R + V+ Q
Sbjct: 2650 SPAKPGPQALPKPAS-PKKPPPGERRSRSPRKPIDSLRDS----RSLSYSPVERRRPSPQ 2704
Query: 351 PPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAP 387
P P S + + S+ G P K+ P+P
Sbjct: 2705 PSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSP 2741
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 65.9 bits (159), Expect = 2e-10
Identities = 104/479 (21%), Positives = 165/479 (34%), Gaps = 84/479 (17%)
Query: 117 REHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPG-SHGLLSPDAGYQPTPLAAPAE 175
R HR + PA P SPT SPG + G ++ G + +PA
Sbjct: 397 RRHRPSP-PATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAP 455
Query: 176 PGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYD 235
K L+ + +G +++ + Q ++ S S D + ++
Sbjct: 456 KPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNG 515
Query: 236 PLSNYSARHLSRASSRDERAAKR---PRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDE 292
+ SR++S R ++ PRG R P P ++ P
Sbjct: 516 EVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPS------------- 562
Query: 293 AATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPP 352
P P TP P + T PP + P
Sbjct: 563 ----PAPPPRRRRTP---TPPPRRRTPSPPPRRR-----------------------SPS 592
Query: 353 PAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPR 412
P + + P Q + S P K++T +PP P K + P K R
Sbjct: 593 PRRYSPPIQRRYSPS-------PPPKRRTASPPPPP-----------KRRASPSPPPKRR 634
Query: 413 ADKKGP--QASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAG 470
P Q SSP K P + K ++P ++ + R +P +R SP+ P
Sbjct: 635 VSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTS 694
Query: 471 RGPPRPLQ-----LPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDE 525
PP P++ P R+ + +PS + + R +R+ + PK K+A S +
Sbjct: 695 SSPP-PVRRGASSSPQRRQSPSPSTRPIRRVSRTPE-------PKKIKKAASPSPQSVRR 746
Query: 526 SEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSS 584
+ G P P+ S S S S+ P P K+ K SP PSP+P +S
Sbjct: 747 VSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAV--PVKKAK-SPTPSPSPPRNS 802
Score = 64.3 bits (155), Expect = 7e-10
Identities = 123/568 (21%), Positives = 199/568 (35%), Gaps = 91/568 (16%)
Query: 247 RASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTAST 306
+ SSR++R +R R R + +P+P++ P + + S S P+ A
Sbjct: 159 KESSREKR--ERSRSPRRRKSRSPSPRRRSSPVRR-ERKRSHSRSPRHRTKSRSPSPAPE 215
Query: 307 PKARAD--PEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQS 364
K + PE + PS + + L+ K + P P +P+
Sbjct: 216 KKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPI--------PEPKEPSPE----- 262
Query: 365 SQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPR 424
K K +K+K P + ++ + +++ RP + R+ + + SPR
Sbjct: 263 -------KNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSR---SYSPR 312
Query: 425 RKAE---RPEGTKKKPSSATPVATSGKGR--PDRPARRPSPT-SGDSRPAAGRGPPRPLQ 478
R+ RP ++ P P + P R RR S + SG S ++ P +
Sbjct: 313 RRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPK 372
Query: 479 LPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSV 538
P ++++ P RK R L AS P+ + R A P+
Sbjct: 373 KPPKRTSSPP------RKTRRLSPSASP--PRRRHRPSPPATPPPKTRHS-------PTP 417
Query: 539 WPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVD 598
S S S S +S + +G KR SP P P S S A D
Sbjct: 418 QQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAAD 477
Query: 599 -------YSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSG 651
Y ++ DS + + VK + GR R P S
Sbjct: 478 SVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQ 537
Query: 652 LTTLFPGQKRRI-----SHLSKQGQEVEPPRRG-----------PAVPPAR--------- 686
T G++RR + + PPRR P+ PP R
Sbjct: 538 KETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYS 597
Query: 687 PPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPT 746
PP + Y + +R +AS P R A SP KRR++H P P+ ++P
Sbjct: 598 PPIQRR--YSPSPPPKRRTASPPPPPKRRASPSPP-------PKRRVSHSPPPKQRSSPV 648
Query: 747 GAKRTLAASGSQSSNGPEPGGQQLKTRT 774
+R+ + S S+ G P + R+
Sbjct: 649 TKRRSPSLS-SKHRKGSSPSRSTREARS 675
Score = 62.8 bits (151), Expect = 2e-09
Identities = 114/501 (22%), Positives = 159/501 (31%), Gaps = 78/501 (15%)
Query: 203 PKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGS 262
P+ + P RH R S V R L S+ S+R S +R + PR +
Sbjct: 329 PRRMPPPPRHRR---SRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKT 385
Query: 263 RG--------------SEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPK 308
R S P TP PK P R S + PG + K
Sbjct: 386 RRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSR--VSVSPGRTSGKVTKHK 443
Query: 309 ARADPEIKATGQPPSKEGL---EAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSS 365
E + P K L E + GG ++ Q + QSS
Sbjct: 444 GTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQ----------RRQYRRQNQQSS 493
Query: 366 QDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGR-PVEKPRADKKGPQASSPR 424
D G + ++ P K+G G+ + R P + R + P+ R
Sbjct: 494 SDSGSSSSSEDER-----PKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRR 548
Query: 425 RKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKS 484
+ P ++ PS A P P R PSP P+ R P P+Q R S
Sbjct: 549 SPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSP-PIQR--RYS 605
Query: 485 TKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALP 544
P + AS P KR +SH+ + + P V P
Sbjct: 606 PSPPPKRRTASPPPPPKRRASPSPPP--KRRVSHSP-----PPKQRSSP----VTKRRSP 654
Query: 545 SLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEK 604
SLSS S S EA+ P + SP P P +SSS +
Sbjct: 655 SLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGAS--------- 705
Query: 605 EVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRIS 664
S P +S S T R++R P E K + + P RR+S
Sbjct: 706 -----SSPQR------RQSPSPSTRPIRRVSRTP------EPKKIKKAASPSPQSVRRVS 748
Query: 665 HLSKQGQEVEPPRRGPAVPPA 685
EP + P PP+
Sbjct: 749 SSRSVSGSPEPAAKKPPAPPS 769
Score = 50.8 bits (120), Expect = 8e-06
Identities = 56/259 (21%), Positives = 92/259 (35%), Gaps = 18/259 (6%)
Query: 209 PRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLS---RASSRDERAAKRPRGSRGS 265
P+R + P P K V +S PP P++ + LS R S R+ + R + +
Sbjct: 621 PKRRASPSPPPKRRVSHSPPPKQRS-SPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPN 679
Query: 266 EPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKE 325
+ ++P+P+ + S S + P +P P + + P K+
Sbjct: 680 KRHSPSPRPRAP-------QTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKK 732
Query: 326 GLEAEGGGLRETKETAVQCDVGDLQPPPAK----PASPAQVQSSQDGGCPKEGKPKKKKT 381
+A + + + V P AK P SP Q QS P K K
Sbjct: 733 IKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSP 792
Query: 382 GAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSAT 441
P+P +G K K K + + +K + KK + KA +A
Sbjct: 793 TPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKK--HKKHKKEKAVAAAAAAAVTPAAI 850
Query: 442 PVATSGKGRPDRPARRPSP 460
AT+ + + P P P
Sbjct: 851 AAATTTLAQ-EEPVAAPEP 868
Score = 42.0 bits (97), Expect = 0.004
Identities = 70/377 (18%), Positives = 124/377 (32%), Gaps = 23/377 (6%)
Query: 210 RRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKR--PRGSRGSEP 267
RR P P+ + + PP P R S R + +R P R P
Sbjct: 547 RRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSP 606
Query: 268 YTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGL 327
P ++ P R S S V + P PK R+ P K + PS
Sbjct: 607 SPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPP-----PKQRSSPVTKR--RSPSLSSK 659
Query: 328 EAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAP 387
+G + A P +P +P S P+++++ +P
Sbjct: 660 HRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTR 719
Query: 388 SCKDGAQGKDKTKDKGRGRPVEKP--RADKKGPQASSPRRKAERPEGTKKKPSSATPVAT 445
+ ++ + K K P + R + SP A++P S +P
Sbjct: 720 PIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTN 779
Query: 446 SGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGAS 505
P + A+ P+P+ P P + D++ K ++K + +
Sbjct: 780 WSPAVPVKKAKSPTPS------------PSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKK 827
Query: 506 QDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQG 565
K +K + A + AA + P A P +++S+++ +L E
Sbjct: 828 HKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHL 887
Query: 566 PPKRLKASPPPSPAPSS 582
K L++ +P S
Sbjct: 888 REKALRSMRKAQVSPQS 904
Score = 40.4 bits (93), Expect = 0.010
Identities = 105/483 (21%), Positives = 169/483 (34%), Gaps = 95/483 (19%)
Query: 393 AQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPS-------------- 438
A K + +DK + EK + +K ++ SPRR+ R +++ S
Sbjct: 142 ASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSP 201
Query: 439 -------SATPVATSGKGRPDRP-----ARRPSPTSGDSRPAAGRGP-PRPLQLPDRKST 485
S +P + P+ P + PS S + P P P+ P S
Sbjct: 202 RHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSP 261
Query: 486 KAPSGKLVER-KARSLDEGASQDAPKLKKRALSHA-DLFGDESEDEAAGP-GVPSVWPSA 542
+ S K E+ K R S+ + + R+ SH S + P PS P
Sbjct: 262 EKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPS--PRR 319
Query: 543 LPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPP----SPAP-----SSSSSSSSSTSSA 593
PS P + PP+R+ PPP S +P SS+S S S+SS+
Sbjct: 320 RPS---------------PRRRTPPRRM--PPPPRHRRSRSPVRRRRRSSASLSGSSSSS 362
Query: 594 GADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDR-GRLARQPPKEEKSEEKGLSGL 652
+ S +K S P + R+ ++ + R A PPK S S
Sbjct: 363 SSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNR 422
Query: 653 T-----TLFPGQKRRISHLSKQGQEVEPPRRGPAVPP----------------ARPPTAQ 691
T ++ PG+ K ++ E P PA P A + Q
Sbjct: 423 TRKSRVSVSPGRTSGKVTKHKGTEKRESP--SPAPKPRKVELSESEEDKGGKMAAADSVQ 480
Query: 692 EVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRT 751
+ R Q Q +S S + + E+ H+ RR H P+ + +P ++
Sbjct: 481 QRRQYRRQNQQSSSDSGSSSSSE-DERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKE 539
Query: 752 LAASG----------SQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPSLQSLK 801
+ G ++ P P + RT + + T + P+R SPS +
Sbjct: 540 TSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRR--RSPSPRRYS 597
Query: 802 KPI 804
PI
Sbjct: 598 PPI 600
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 65.1 bits (157), Expect = 4e-10
Identities = 92/380 (24%), Positives = 139/380 (36%), Gaps = 47/380 (12%)
Query: 216 VPSGKYVVDNSRPPTD---LEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAP 272
+P G V SRP D L PLS +S ++ S + A K S+ S+P+
Sbjct: 144 MPEGADTV--SRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKE--SSKTSKPHKVTK 199
Query: 273 KKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGG 332
+ P +++ S E E ++ T+ + R E KA PP K +
Sbjct: 200 EHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKA---PPPKAAFKEPKM 256
Query: 333 GLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKT-GAPPAPSCKD 391
L+ETK + G PPP P + ++ ++ D P K KK + G+ AP
Sbjct: 257 ALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSP 316
Query: 392 GAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRP 451
DK KP DK + + ++E E K + +
Sbjct: 317 RTSSSSSFSDK-------KPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKS 369
Query: 452 DRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKL 511
+ PS +S S ++ S PS + RS+ E +
Sbjct: 370 ESAQSSPSNSSSSSDSSS-------------DSDFEPSQNHSQGPLRSMVEDLQSE---- 412
Query: 512 KKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLK 571
+D S +EAAG P S L S+SD+ +DSSL P + PP +
Sbjct: 413 ------ESDEDDSSSGEEAAGKTNPG-RDSRLSFSDSESDNSADSSL--PSREPPPPQ-- 461
Query: 572 ASPPPSPAPSSSSSSSSSTS 591
PPP + S S S S
Sbjct: 462 -KPPPPNSKVSGRRSPESCS 480
Score = 57.8 bits (138), Expect = 6e-08
Identities = 71/296 (23%), Positives = 110/296 (37%), Gaps = 54/296 (18%)
Query: 354 AKPASPAQVQSSQDGGCPK-EGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPR 412
+K Q +SS+D EG+ K++ PP + K+ +TK + P+
Sbjct: 215 SKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTS-----PK 269
Query: 413 ADKKGPQASSPRRKAERPE-GTKKKPSSATPVATSGKGRPDRPARRPSPTSG----DSRP 467
P PR ++RP KPS+ +S KG P P +S D +P
Sbjct: 270 GGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKP 329
Query: 468 AAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESE 527
A + R + KA S +KA ++E S+D K SE
Sbjct: 330 AKDKSSTRG------EKVKAESEPREAKKALEVEESNSEDEASFK-------------SE 370
Query: 528 DEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSS 587
+ P + S SSDS SDSD +QGP + S
Sbjct: 371 SAQSSP--------SNSSSSSDSSSDSDFEPSQNHSQGPLR----------------SMV 406
Query: 588 SSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEK 643
S +D D S+ +E ++P + F++S S + D +R+PP +K
Sbjct: 407 EDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQK 462
Score = 34.3 bits (77), Expect = 0.75
Identities = 45/197 (22%), Positives = 69/197 (35%), Gaps = 7/197 (3%)
Query: 567 PKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSV 626
PK+ K S A SS +S + + E S +E ++ TS
Sbjct: 172 PKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSR 231
Query: 627 KTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPAR 686
K + GRL PKEEK+ + ++ ++ S +G PP P R
Sbjct: 232 KLGE-GRL----PKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKR 286
Query: 687 PPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHIS--APGEKRRIAHIPNPRLAAA 744
P TA +Q + +S AP S S S P + + + +
Sbjct: 287 PATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESE 346
Query: 745 PTGAKRTLAASGSQSSN 761
P AK+ L S S +
Sbjct: 347 PREAKKALEVEESNSED 363
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 65.1 bits (157), Expect = 4e-10
Identities = 94/403 (23%), Positives = 141/403 (34%), Gaps = 61/403 (15%)
Query: 238 SNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGS-------CDARFSDSE 290
S+ +R R SR + ++ + P+T +P + S + +SDS
Sbjct: 214 SDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSR 273
Query: 291 DEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQ 350
+ P + T R+ + S G GG + + A G
Sbjct: 274 SPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQ-RSGAHGGRPGSAH 332
Query: 351 PPPAKPASPA-QVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVE 409
PP KP+SP+ +V+ P K+ P+P +QG+ G GR
Sbjct: 333 SPPDKPSSPSPRVRDKAAAAAPTPPARGKES----PSPRSAPSSQGRGGRAAGGAGRRRR 388
Query: 410 KPRADKKG-PQASSPRRKAER------PEGTKKKPSSATPVATSGKGRPDRPARRPSPTS 462
+ R ++ AS+PRR+ R P G+ + S A + SG GR A P P
Sbjct: 389 RRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRG---APGPGPEP 445
Query: 463 GDSRPAAGRG------PPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRAL 516
G R G G PPR R ++ +PS R+ + +S+ +
Sbjct: 446 GSERGHGGHGKRAKERPPRA-----RPASTSPSPGAHGRRGGPEGKSSSRSPGPHPRSWS 500
Query: 517 SHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPP- 575
S S P PS PS LS D D + + EA +R ++ P
Sbjct: 501 SSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRSYSPI 560
Query: 576 -------PS-------------------PAPSSSSSSSSSTSS 592
PS P+PSSSSS SS S
Sbjct: 561 RKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYS 603
Score = 44.7 bits (104), Expect = 6e-04
Identities = 75/329 (22%), Positives = 104/329 (31%), Gaps = 86/329 (26%)
Query: 163 AGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYV 222
A PTP A E S S S GR GG G + RR R
Sbjct: 350 AAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAG----------RRRRRRR-------- 391
Query: 223 VDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSC 282
R SR +A R RG R P P
Sbjct: 392 -----------------------RRRRSRSSASAPRRRGRRRPRPAPPRGSSR----SLS 424
Query: 283 DARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAV 342
AR S PG P +P S+ G GG + KE
Sbjct: 425 RARSSSDSGSGRGAPGPGP------------------EPGSERG---HGGHGKRAKE--- 460
Query: 343 QCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDK 402
+PP A+PAS S G + G P+ K + P P + + + +K +
Sbjct: 461 -------RPPRARPAS----TSPSPGAHGRRGGPEGKSSSRSPGPHPRSWSSSRSPSKSR 509
Query: 403 GRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGR---PDRPARRPS 459
R ++P + + P P + + EG + + S A + R P R RR S
Sbjct: 510 SRSAE-KRPHSPSRSPSPKKPLSRDKDGEG-RARHSEAEATRARRRSRSYSPIRKRRRDS 567
Query: 460 PTSGDSRP-AAGRGPPRPLQLPDRKSTKA 487
P+ + R + R P P P S+ +
Sbjct: 568 PSFMEPRRITSARKRPIPYYRPSPSSSSS 596
Score = 40.8 bits (94), Expect = 0.008
Identities = 95/457 (20%), Positives = 154/457 (33%), Gaps = 76/457 (16%)
Query: 317 ATGQPPSKEGLEAEGGGLRETKETAVQ--CDVGDLQPPPAKPASPAQVQSSQ-DGGCPKE 373
++ PP K+ + +GG R K+ ++ C G P K S + + + D G ++
Sbjct: 162 SSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGSRRK 221
Query: 374 GKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAER-PEG 432
+ + + + K K K+K + +KK P SP R++ R G
Sbjct: 222 RRHRSRSS--------------KCKRKEKNK---------EKKRPHTESPGRRSHRHSSG 258
Query: 433 TKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKL 492
+ PS ++ + S P R S+ ++G P +PSG
Sbjct: 259 SSHSPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSP------------SPSG-- 304
Query: 493 VERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDS 552
G+ +P+ G + A G P S SS S
Sbjct: 305 ----------GSGWGSPQRN----------GGSGQRSGAHGGRPGSAHSPPDKPSSPSPR 344
Query: 553 DSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDP 612
D + A PP R K SP P APSS + AG + +
Sbjct: 345 VRDKAAA--AAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASA 402
Query: 613 MEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQE 672
R + R L+R + +G G PG +R K+ +E
Sbjct: 403 PRRRGRRRPRPAPPRGSSRS-LSRARSSSDSGSGRGAPG-PGPEPGSERGHGGHGKRAKE 460
Query: 673 VEPPRRGPAVPPARPPTAQEVCYLRAQQAQR----------ASASLLQAPARLAEKSPSV 722
PPR PA P + + R +S S ++ +R AEK P
Sbjct: 461 -RPPRARPASTSPSPGAHGRRGGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRPHS 519
Query: 723 HISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQS 759
+P K+ ++ + A + A+ T A S+S
Sbjct: 520 PSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRS 556
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 64.7 bits (156), Expect = 5e-10
Identities = 177/852 (20%), Positives = 290/852 (34%), Gaps = 152/852 (17%)
Query: 37 RGSGAPGDGGEAPPAAGLGYDPYNPELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIE 96
+ + APG G+ P G P KP + E+ G E +A
Sbjct: 237 KAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE-----------EEAPA 285
Query: 97 AVRSEVELEQRRYRELLETTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSH 156
RS+V+ ++ +L+ R+A APA G A+P P A +A G
Sbjct: 286 GTRSQVKASEK----ILQV----RAASAPAKGTPGKGATPA--PPGKAGAVASQTKAGKP 335
Query: 157 GLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPV 216
S + + + + P +K L + G+ G A A PR+ + P
Sbjct: 336 EEDSESSSEESSD-SEEETPAAKALLQAKASGKTSQVGAASA-----PAKESPRKGAAPA 389
Query: 217 PSGKY--VVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKK 274
P GK V ++ E S+ + A ++ + + K P+ S P +P+K
Sbjct: 390 PPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 449
Query: 275 LCDPF--------------------GSCDARFSDSEDEAATVP--------GNEPTTAST 306
P + SDS+ EA G P
Sbjct: 450 GAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPA 509
Query: 307 PKARADPEIKATGQ-PPSKEGL---EAEGGGLRETKETAVQ--CDVGDLQPP----PAKP 356
P K G PP K G A+ G E E++ + D D + P PA+
Sbjct: 510 STMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE 569
Query: 357 ASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCK--DGAQGKDKTKDKGRGR--PVEKPR 412
S + ++ P +G P+K A + K D ++ +++ D P
Sbjct: 570 KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA 629
Query: 413 ADKKG----PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPA-RRPSPTSGDSRP 467
A K PQ + +K K P A G PA P+ G RP
Sbjct: 630 AQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP 689
Query: 468 AAGRGPPRPLQLPDRKSTKAPS-------GKLVERKARS------LDEGASQDAP----- 509
A + K+ A + GK ++ KA S L +G + P
Sbjct: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP 749
Query: 510 -----KLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQ 564
K +K+ S + +SE+ AA P + ++ + + + S+ G A
Sbjct: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 809
Query: 565 G------------------PPKR------LKASPPPSPAPSSSSSSSSSTSSAGADVDYS 600
G PP R + A P S + ++++ + G + D
Sbjct: 810 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG 869
Query: 601 ALEKEVDFDSDPMEECLRIFNESTSVKTED-RGRLA---RQPPKEEKSEEKGLSGLTTLF 656
+ E+E SD EE + S KT R LA P K G +G +
Sbjct: 870 SSEEE----SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 657 PGQKRRISHLSKQG-------------QEVEPP------RRGPAVPPARPPTAQEVCYLR 697
G++ S++ Q ++PP R PA P A P AQ R
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 698 AQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIP--NPRLAAAPTGAKRTLAAS 755
+A ++A + + + P+ PG + + +P +PR+A + A + +
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKE 1045
Query: 756 GSQSSNGPEPGG 767
S+ S+G + G
Sbjct: 1046 SSRISDGKKQEG 1057
Score = 47.8 bits (112), Expect = 7e-05
Identities = 116/528 (21%), Positives = 177/528 (33%), Gaps = 105/528 (19%)
Query: 244 HLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTT 303
HL RA RAA+ + G + + P L D + + + + E
Sbjct: 17 HLLRAGY--VRAAREVKEQSGQKCFLAQPVTLLDIY----THWQQTSELGRKRKAEEDAA 70
Query: 304 ASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKETAVQCDVGDLQPPPAKPASP 359
K R I + +E EAE L T + + D+ AK +
Sbjct: 71 LQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETE 130
Query: 360 AQVQSSQDGGCPKEGKPKKKK-TGAPPAPSCKDGAQGK--DKTKDKGR-------GRP-- 407
++ P GK +G P S + A +T+++G +P
Sbjct: 131 KAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
Query: 408 VEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRP 467
V +AD SS + + KP+ + S K P R A GD P
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP 250
Query: 468 AAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESE 527
G LP K K P E ++ S +EG+ ESE
Sbjct: 251 QVKGG-----ALPPAKRAKKP-----EEESESSEEGS--------------------ESE 280
Query: 528 DEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSS 587
+EA P+ S S+ A+G P + +PAP + +
Sbjct: 281 EEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGK-----GATPAPPGKAGAV 326
Query: 588 SSTSSAGADVDYSALEKEVDFDSDPMEECLR-IFNESTSVKTEDRGRLARQPPKEEKSEE 646
+S + AG + S E DS+ + + S KT G A P KE S
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG-AASAPAKE--SPR 383
Query: 647 KGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASA 706
KG + P + GPAV A+ +E +Q + S
Sbjct: 384 KGAA---------------------PAPPGKTGPAVAKAQAGKREE----DSQSSSEESD 418
Query: 707 SLLQAPARL--AEKSPSVH-ISAPGEKRRIAHIPNPRLAAAPTGAKRT 751
S +APA+ + K+P V SAP ++ +PR AAP ++T
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKE-------SPRKGAAPAPPRKT 459
Score = 45.4 bits (106), Expect = 3e-04
Identities = 186/906 (20%), Positives = 283/906 (31%), Gaps = 184/906 (20%)
Query: 35 GARGSGA----PGDGGEAPPAAGLGY-------------DPYNPELPKPPAQRENGTLGL 77
G G GA PG G A P+A +G D + E+P A + +LG
Sbjct: 515 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGN 574
Query: 78 GEEPRPDVLELELVNQAIEAVRSEVELEQR--RYRELLETTREHRSAEAPALAPRGPNAS 135
+ +P + Q V +V+ E+ E++ S EAPA A A
Sbjct: 575 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA-AMTAAQAK 633
Query: 136 PTVG-PDEDAFPLAFD--------------YSPGSHGLLSPDAGYQPTPLAA---PAEPG 177
P + P A P + +P G + AG P PAE
Sbjct: 634 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
Query: 178 SKYSLASLDR---------GQGRGGGGGGALEYVPKAVSQPRRHS-----RPVPSGKYVV 223
S + + GQ + G G + KA S P + S PV GK
Sbjct: 694 SSSEESDSEEEKTGLAVTVGQAKSVGKGLQV----KAASVPVKGSLGQGTAPVLPGKTGP 749
Query: 224 DNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCD 283
++ + + D S S S E AA P + S T A
Sbjct: 750 TVTQVKAEKQEDSES-------SEEESDSEEAAASPAQVKTSVKKTQAKANPA------- 795
Query: 284 ARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKE 339
A + S + PG T A+ K R+ ++K + P + A G + +
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 340 TAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKK---------------KTGAP 384
TA Q G P +S + S ++ + KP K + GA
Sbjct: 856 TAAQAQTG---PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 912
Query: 385 PAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAE----------RPEGTK 434
P P K G K G E+ +D + P A + + + P G
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPA 972
Query: 435 KKPSSATPVATSGKGRPDRPARRPSPTSGDSR---PAAGRGPP----RPLQLPDRKSTKA 487
P+ A +T K R R S + + PA P + +P A
Sbjct: 973 ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 488 PSGKLV----ERKARSLDEGASQDAPK------------LKKRALSHADLFGDESE---- 527
P + +++ + +G Q+ P L + AL E++
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1092
Query: 528 --------DEAAG----------------------PGVPSVWPSA-LPSLSSDSDSDSDS 556
D A G P +P V + P S DS+ SDS
Sbjct: 1093 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS 1152
Query: 557 SLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEEC 616
S G E P+ K++ P PS + + T++ ++ D A + + S M
Sbjct: 1153 SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSL--LSGYMTPG 1210
Query: 617 LRIFNESTSVKTED-------RGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQ 669
L N S T LA + + K E K L P + +
Sbjct: 1211 LTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTT 1270
Query: 670 GQEVEPPRRGPAVPPARPPTAQE---VCYLRAQ---QAQRASASLLQAPARLAEKSPSVH 723
Q+ P++G P A Q C L + AS+++ L E+
Sbjct: 1271 PQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKV 1330
Query: 724 ISAPGEKRRIAHIPNPRLAAAPTGAKRTL---------AASGSQSSNGPEPGGQQLKTRT 774
+ E R R + A RT A G ++S PE K +
Sbjct: 1331 VDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA 1390
Query: 775 LSGMAS 780
AS
Sbjct: 1391 KRDKAS 1396
Score = 43.1 bits (100), Expect = 0.002
Identities = 69/327 (21%), Positives = 114/327 (34%), Gaps = 75/327 (22%)
Query: 236 PLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAAT 295
P S+ + S +SS E + P+G++ + P P + A S+ + A +
Sbjct: 1140 PESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPS 1199
Query: 296 ------------VPGNEPTTASTPKARADPEIKAT------------------------- 318
P N + +TPK + P + +T
Sbjct: 1200 QSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPK 1259
Query: 319 --------GQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGC 370
G P K +G G + A+Q ++ P + AQVQ+S
Sbjct: 1260 TGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVL 1319
Query: 371 PKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGR-GRPVEKPRADKKGPQASSPRRKAER 429
+ + ++KK D TK+ R G K + P A +PR K ++
Sbjct: 1320 TELLEQERKKV--------------VDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKK 1365
Query: 430 PEGT-KKKPSSATP--VATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTK 486
G + +S +P +T+ KG+ R SGD + G+G L + +
Sbjct: 1366 KLGAGEGGEASVSPEKTSTTSKGKAKR-----DKASGDVKEKKGKG-----SLGSQGAKD 1415
Query: 487 APSGKLVERKARSLDEGASQDAPKLKK 513
P +L +K EG Q PK KK
Sbjct: 1416 EPEEEL--QKGMGTVEGGDQSNPKSKK 1440
Score = 35.8 bits (81), Expect = 0.26
Identities = 79/385 (20%), Positives = 140/385 (36%), Gaps = 53/385 (13%)
Query: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPK-LKKRALSH---ADLFGDESEDEAAGPGVP 536
+ + +A + K R A + D P +K++A + A G+ A G V
Sbjct: 90 EEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVA 149
Query: 537 SVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGAD 596
++ P S++ +++ E P A+ P + + SSS TSS+
Sbjct: 150 NLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS--- 206
Query: 597 VDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPK--EEKSEEKGLSGLTT 654
E D + P + ++ S S K + A P K + + KG +
Sbjct: 207 ------SDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPA 260
Query: 655 LFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPAR 714
+ S S++G E E PA ++ ++++ +RA ASA P +
Sbjct: 261 KRAKKPEEESESSEEGSESE--EEAPAGTRSQVKASEKILQVRA-----ASAPAKGTPGK 313
Query: 715 LAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPE---PGGQQLK 771
A +P PG+ +A + G + S S+ S+ E P + L
Sbjct: 314 GATPAP------PGKAGAVA-------SQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 772 TRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLK 831
SG S+ A +P+ +S +K P G P V + + K
Sbjct: 361 QAKASGKTSQVGA-------ASAPAKESPRKGAAPAPPGKTGPAVAK--------AQAGK 405
Query: 832 FCTSNQEAIEKALNEEKVAYDRSPS 856
+Q + E++ +EE+ PS
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPS 430
Score = 32.3 bits (72), Expect = 2.8
Identities = 48/191 (25%), Positives = 70/191 (36%), Gaps = 51/191 (26%)
Query: 258 RPRGSRGSEPY--TPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEI 315
R R G +P TP KK + E A+V + +T S KA+ D
Sbjct: 1345 RKRKLSGDQPAARTPRSKK--------KKKLGAGEGGEASVSPEKTSTTSKGKAKRD--- 1393
Query: 316 KATGQPPSKEGLEAEGG-GLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEG 374
KA+G K+G + G G ++ E +Q +G ++ GG +
Sbjct: 1394 KASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVE-----------------GG--DQS 1434
Query: 375 KPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTK 434
PK KK +K K R + EK KK +AS+ + +E P K
Sbjct: 1435 NPKSKK----------------EKKKSDKRKKDKEKKEKKKKAKKAST--KDSESPSQKK 1476
Query: 435 KKPSSATPVAT 445
KK T T
Sbjct: 1477 KKKKKKTAEQT 1487
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 63.2 bits (152), Expect = 1e-09
Identities = 142/632 (22%), Positives = 219/632 (34%), Gaps = 77/632 (12%)
Query: 157 GLLSPDAGYQPTPLAAPAEP------GSKYSLASLDRGQGRGGGGGGAL-EYVPKAVSQP 209
GLL+P P P P P G+ ++ + GG GG + E P+A P
Sbjct: 23 GLLTPRPPGSPRP-PPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRA--GP 79
Query: 210 RRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYT 269
R SRP SG+ + + P + P+S+ RAS +G R S T
Sbjct: 80 TRTSRPPASGRG--ERAPPAKNTSPGPVSSPG-----RASGTTRPGPLGQKGLRISAEET 132
Query: 270 PAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEA 329
A K + D + PG P+ A ++RA +P
Sbjct: 133 VARGKATEAPKRSALSAGARRDTSGPTPGT-PSPAMARRSRAAGTEVGLPRPAPSARPRP 191
Query: 330 EGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSC 389
G R++ +A + +P+ A+ + S GG + + P +
Sbjct: 192 PTEGPRKSVSSASEHST-------TEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA 244
Query: 390 KDGAQGKDKTKDKGR-GRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGK 448
+ G + + +P K + PQ + PR+ A G P S++P+AT
Sbjct: 245 RSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG----PLSSSPLATPSP 300
Query: 449 GRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDA 508
P P+ PS + S PA P + + +A L L Q
Sbjct: 301 SAPPSPSAPPSLQTLPSPPATP--PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 358
Query: 509 PKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPK 568
P L L + + P P + P A PS + ++L Q P
Sbjct: 359 PALALPPL----------QAPPSPPASPPLSPLATPS------PQAPNALAVHLLQAP-- 400
Query: 569 RLKASPPPSPA-------PSSSSSSSSSTSSAGADVDYSALEKEVDFD---SDPMEECLR 618
SPPPSP P+S S S+T + A +A +V S PM
Sbjct: 401 ---FSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 457
Query: 619 IFNESTSVKTEDRGRLARQPPKEEKSEE----KGLSGLTTLFPGQKRRISHLSKQGQEVE 674
++ +LA+ PP+ + + L FPGQ +
Sbjct: 458 PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQ-------APFSPSAS 510
Query: 675 PPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIA 734
P A PP + P L+ + AS +L QAP R P +S P +A
Sbjct: 511 LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTL-QAPRRPPTPGPDTSVSGPRLTLALA 569
Query: 735 HIPNPRLAAAP--TGAKRTLAASGSQSSNGPE 764
P P + +P T + LA S +++ PE
Sbjct: 570 PGPPPPPSRSPSSTLSGPDLAGHSSSATSTPE 601
Score = 54.3 bits (129), Expect = 7e-07
Identities = 137/573 (23%), Positives = 183/573 (31%), Gaps = 110/573 (19%)
Query: 258 RPRGS-RGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIK 316
RP GS R P TPA ++ G+ A E A G S P RA P
Sbjct: 28 RPPGSPRPPPPVTPAALRV---LGAAGAVGRKPLAERAGGIGGATIPESAP--RAGPT-- 80
Query: 317 ATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQS-SQDGGCPKEGK 375
T +PP A G G R PPAK SP V S + G + G
Sbjct: 81 RTSRPP------ASGRGERA---------------PPAKNTSPGPVSSPGRASGTTRPGP 119
Query: 376 --------------PKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQAS 421
+ K T AP + GA+ G P R+ G +
Sbjct: 120 LGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVG 179
Query: 422 SPR-----RKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGR--GPP 474
PR R EG +K SSA+ +T+ R RRPS G RPA+
Sbjct: 180 LPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAAR--RRPSAGGGLQRPASRSLSSSA 237
Query: 475 RPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPG 534
PL P R PS + R A PK K +D A G
Sbjct: 238 TPLSSPARSG---PSARGTPRAP------AHPSQPKPKGLQALRPPQVTPPRKDAAPALG 288
Query: 535 VPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAG 594
S P A PS S+ P + P L+ P P P S +++S + +
Sbjct: 289 PLSSSPLATPSPSA------------PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQ 336
Query: 595 ADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTT 654
A + S P+ ++ + PP LS L T
Sbjct: 337 ATHSF--------LPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP-----LSPLAT 383
Query: 655 LFPGQKRRIS-HLSKQ--GQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQA 711
P ++ HL + PP + P PPA PP + A +A SL
Sbjct: 384 PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPS-----ATPPSQAPPSLAAP 438
Query: 712 PARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLK 771
P ++ P+ +P A P A LAA Q + P L
Sbjct: 439 PLQVPPSPPASPPMSPS-------------ATPPPQAPPPLAAPPLQLAKPPPQAPPALA 485
Query: 772 TRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPI 804
T L + S + P + SPS P+
Sbjct: 486 TPPLQALPSPPAS--FPGQAPFSPSASLPMSPL 516
Score = 48.9 bits (115), Expect = 3e-05
Identities = 94/408 (23%), Positives = 145/408 (35%), Gaps = 90/408 (22%)
Query: 406 RPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRP------- 458
R K A + P A +P RP G+ + P TP A G R+P
Sbjct: 5 RDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG 64
Query: 459 ---------SPTSGDSR----PAAGRGP---------PRPLQLPDRKSTKAPSGKLVERK 496
+P +G +R PA+GRG P P+ P R S G L ++
Sbjct: 65 IGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKG 124
Query: 497 AR-----SLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSD 551
R ++ G + +AP K+ ALS G + PG PS P+++ S
Sbjct: 125 LRISAEETVARGKATEAP--KRSALS----AGARRDTSGPTPGTPS------PAMARRSR 172
Query: 552 SDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTS----------SAGADVDYSA 601
+ + + +G P + P P P S SS+S ST+ SAG + A
Sbjct: 173 A-AGTEVGLP--RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPA 229
Query: 602 LEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKR 661
+ + + P+ R + RG R P + + KGL L
Sbjct: 230 -SRSLSSSATPLSSPARSGPSA-------RG-TPRAPAHPSQPKPKGLQAL--------- 271
Query: 662 RISHLSKQGQEVEPPRR--GPAVPP-ARPPTAQEVCYLRAQQAQRASASLLQAPARLAEK 718
+ +V PPR+ PA+ P + P A + S L +P
Sbjct: 272 -------RPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPS 324
Query: 719 SPSVHISAPGEKRRIAHIPNP---RLAAAPTGAKRTLAASGSQSSNGP 763
+ + +P + + +P+P LA P A LA Q+ P
Sbjct: 325 QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP 372
Score = 48.5 bits (114), Expect = 4e-05
Identities = 148/672 (22%), Positives = 204/672 (30%), Gaps = 111/672 (16%)
Query: 18 GAPGGPCRRPYCHFRHRGARGSGAPGDGGEA-------PPAAGLGY--DPYNPELPKPPA 68
GA G R+P R G G+ P A PPA+G G P P P +
Sbjct: 48 GAAGAVGRKPLAE-RAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVS 106
Query: 69 Q--RENGTLG---LGEEP-RPDVLELELVNQAIEAV-RSEVELEQRRYRELLETTREHRS 121
R +GT LG++ R E +A EA RS + RR +T+
Sbjct: 107 SPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARR-----DTSGPTPG 161
Query: 122 AEAPALAPRGPNASPTVG------------PDEDAFPLAFDYSPGSHGLLSPDAGYQPTP 169
+PA+A R A VG P E S S SP A +P+
Sbjct: 162 TPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSA 221
Query: 170 LAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSR-- 227
P S+ SL+S G + P+A + P S+P P G + +
Sbjct: 222 GGGLQRPASR-SLSSSATPLSSPARSGPSARGTPRAPAHP---SQPKPKGLQALRPPQVT 277
Query: 228 PPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRG--SEPYTPAPKKLCDPFGSCDAR 285
PP L S+ L+ S + P + S P TP P + GS +
Sbjct: 278 PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATP-PSQATTSLGSPTLQ 336
Query: 286 FSDSE------DEAATVPGNEPTTASTPKARADPEIKATG----------QPPSKEGLEA 329
+ S AT P P + P +A P A+ Q P+ +
Sbjct: 337 ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHL 396
Query: 330 EGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSC 389
VQ PP P++ Q+ P P P +PS
Sbjct: 397 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 456
Query: 390 KDGAQGKDKTKDKG---RGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATS 446
Q P + P A P + P A P PS++ P++
Sbjct: 457 TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 516
Query: 447 GKGRPDRP---------------------ARRPSPTSGDSRPAAGR--------GPPRPL 477
P P A R PT G +G GPP P
Sbjct: 517 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPP 576
Query: 478 QLPDRKSTKAP-------SGKLVERKARSLDEG----ASQDAPKLKKRALSHADLFGDES 526
+ P S + R D G A+ P + A H +
Sbjct: 577 SRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP 636
Query: 527 EDEAA---GPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSS 583
A PG P WP A +D E +GP A P PS
Sbjct: 637 APPLAFRGAPGAPLPWPPA------TGPGSADGLCTIYETEGPESATPAPGALDPGPSPG 690
Query: 584 SSSSSSTSSAGA 595
+S + + AGA
Sbjct: 691 TSGGKAAAGAGA 702
Score = 42.0 bits (97), Expect = 0.004
Identities = 110/523 (21%), Positives = 159/523 (30%), Gaps = 67/523 (12%)
Query: 114 ETTREHRSAEAP-----ALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPT 168
ET ++ EAP + R + PT G A + GL P +P
Sbjct: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPR 190
Query: 169 PLAA----PAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVD 224
P S++S R GG L+ R SR + S
Sbjct: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ---------RPASRSLSSSA---- 237
Query: 225 NSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEP--YTPAPKKLCDPFGSC 282
T L S SAR RA + + +P+G + P TP K G
Sbjct: 238 -----TPLSSPARSGPSARGTPRAPAHPSQP--KPKGLQALRPPQVTPPRKDAAPALGPL 290
Query: 283 DARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAV 342
+ P P+ ++ P A P ++ PP+ +A +
Sbjct: 291 SSS-----------PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT----TSLGSPTL 335
Query: 343 QCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDK 402
Q L PP P + Q+ P P P +P Q +
Sbjct: 336 QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 395
Query: 403 GRGRPVEKPRADKKGPQASSPRRKAERPEGT---KKKPSSATPVATSGKGRPDRPARRPS 459
P P + S P P T + PS A P P P PS
Sbjct: 396 LLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPS 455
Query: 460 PTSGDSRPAAGRGPPRPLQLPDRKSTKA----PSGKLVERKARSLDEGASQDAPKLKKRA 515
T P PP L P ++ A P L A + + L
Sbjct: 456 ATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 515
Query: 516 LSHADLFGDESEDEAAGPGV---PSVWPSALPSLSSDSDSDS---DSSLGFPEAQGPPKR 569
L+ ++ A P + PS P A P+L + + D+S+ P
Sbjct: 516 LATPP---PQAPPVLAAPLLQVPPS--PPASPTLQAPRRPPTPGPDTSVSGPRLT---LA 567
Query: 570 LKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDP 612
L PPP P+ S SS+ S + + S E+ +DS P
Sbjct: 568 LAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGP 610
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 62.4 bits (150), Expect = 3e-09
Identities = 151/758 (19%), Positives = 273/758 (36%), Gaps = 100/758 (13%)
Query: 114 ETTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAP 173
ET E + + PA + + S P A P +PG G ++P P A
Sbjct: 209 ETDVEGKPSVKPAQV-KASSVSTKESPARKAAP-----APGKVGDVTPQVKGGALPPAKR 262
Query: 174 AEPGSKYSLASLDRGQGRGGGGGGALEYVPKA--VSQPRRHSRPVPSGKYVVDNSRPPTD 231
A+ + S +S + + G V + + Q R S P PP
Sbjct: 263 AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGK 322
Query: 232 LEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSED 291
+ ++A +E + S SE TPA K L A S+
Sbjct: 323 AG-------AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ----AKASGKTSQV 371
Query: 292 EAATVPGNEPTTASTPKARADPEIKATGQPPSKEG---LEAEGGGLRE-TKETAVQCDVG 347
AA+ P E +P+ A P PP K G +A+ G E ++ ++ + D
Sbjct: 372 GAASAPAKE-----SPRKGAAPA------PPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
Query: 348 DLQPPPAKPASPA-QVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGR 406
+ P AKP+ A QV+++ P + P+K APP + AQ + +++
Sbjct: 421 EEAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 407 PVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSP------ 460
E+ +D++ A + + + + KP+S + GKG P + P
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQ 537
Query: 461 ----------TSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLD-EGASQDAP 509
+S +S ++ P + KS G +++ K S +G Q A
Sbjct: 538 VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL----GNILQAKPTSSPAKGPPQKAG 593
Query: 510 KLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKR 569
+ + + + ES +E++ P+A+ + + + +L P+ + PK+
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA------AQAKPALKIPQTKACPKK 647
Query: 570 LKASPPPSPAP-----------SSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLR 618
+ AP +++S + S+ + A + +SD EE
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707
Query: 619 IFNESTSVKTEDRG---RLARQPPKEEKSEEKG--LSGLTTLFPGQKRRISHLSKQGQEV 673
+ K+ +G + A P K + L G T Q + + E
Sbjct: 708 LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE 767
Query: 674 EPPRRGPAVPPARPPTAQEVCYLRAQQAQ----------RASASLLQAPARLAEKSPSVH 723
E A PA+ T+ + +A A A ++ A A+ ++SPS
Sbjct: 768 ESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS-K 826
Query: 724 ISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTT 783
+ P + + + A+ P+ K A+ +Q+ GPE + + S ++T
Sbjct: 827 VKPPVRNPQNSTVLARGPASVPSVGK--AVATAAQAQTGPEEDSGSSEEESDSEEEAETL 884
Query: 784 TTIIPK------RIAHSPSLQSLKKPIIPKEFGGKVPT 815
+ P R A +P+ +S +K P G P+
Sbjct: 885 AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS 922
Score = 47.8 bits (112), Expect = 7e-05
Identities = 116/528 (21%), Positives = 177/528 (33%), Gaps = 105/528 (19%)
Query: 244 HLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTT 303
HL RA RAA+ + G + + P L D + + + + E
Sbjct: 17 HLLRAGY--VRAAREVKEQSGQKCFLAQPVTLLDIY----THWQQTSELGRKRKAEEDAA 70
Query: 304 ASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKETAVQCDVGDLQPPPAKPASP 359
K R I + +E EAE L T + + D+ AK +
Sbjct: 71 LQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETE 130
Query: 360 AQVQSSQDGGCPKEGKPKKKK-TGAPPAPSCKDGAQGK--DKTKDKGR-------GRP-- 407
++ P GK +G P S + A +T+++G +P
Sbjct: 131 KAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
Query: 408 VEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRP 467
V +AD SS + + KP+ + S K P R A GD P
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP 250
Query: 468 AAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESE 527
G LP K K P E ++ S +EG+ ESE
Sbjct: 251 QVKGG-----ALPPAKRAKKP-----EEESESSEEGS--------------------ESE 280
Query: 528 DEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSS 587
+EA P+ S S+ A+G P + +PAP + +
Sbjct: 281 EEA---------PAGTRSQVKASEKILQVRAASAPAKGTPGK-----GATPAPPGKAGAV 326
Query: 588 SSTSSAGADVDYSALEKEVDFDSDPMEECLR-IFNESTSVKTEDRGRLARQPPKEEKSEE 646
+S + AG + S E DS+ + + S KT G A P KE S
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG-AASAPAKE--SPR 383
Query: 647 KGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASA 706
KG + P + GPAV A+ +E +Q + S
Sbjct: 384 KGAA---------------------PAPPGKTGPAVAKAQAGKREE----DSQSSSEESD 418
Query: 707 SLLQAPARL--AEKSPSVH-ISAPGEKRRIAHIPNPRLAAAPTGAKRT 751
S +APA+ + K+P V SAP ++ +PR AAP ++T
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAPAKE-------SPRKGAAPAPPRKT 459
Score = 40.0 bits (92), Expect = 0.014
Identities = 77/351 (21%), Positives = 121/351 (34%), Gaps = 49/351 (13%)
Query: 287 SDSEDEAATVPGNEPTTASTPKARADPEIKA--TGQPPSKEGLEAEGGGLRETKETAVQC 344
S+S +E++ +E A+ A+A P +K T P K A T
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667
Query: 345 DVGDLQPPPAKPASPAQVQSSQ----DGGCPKEGKPKKKKTGAP----PAPSCKDGAQGK 396
G P +SPA +Q D +E +++KTG A S G Q K
Sbjct: 668 KAGTATSPAG--SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVK 725
Query: 397 DKTKD-KGR-GRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRP 454
+ KG G+ K GP + + + + + ++ S + A S P +
Sbjct: 726 AASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAAS----PAQV 781
Query: 455 ARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKR 514
T + PAA R P K T + GK+V A++ S+ P ++
Sbjct: 782 KTSVKKTQAKANPAAARAP-------SAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNP 834
Query: 515 ALSHADLFGDESEDEAAGPGVPSVWPSALP---SLSSDSDSDSDSSLGF----------- 560
S G S + P S SS+ +SDS+
Sbjct: 835 QNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH 894
Query: 561 -------PEAQGPPKRLKASPPPSPAPSSSSS---SSSSTSSAGADVDYSA 601
P + P K +PP PS++ + S +SS +D D A
Sbjct: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEA 945
Score = 35.8 bits (81), Expect = 0.26
Identities = 79/385 (20%), Positives = 140/385 (36%), Gaps = 53/385 (13%)
Query: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPK-LKKRALSH---ADLFGDESEDEAAGPGVP 536
+ + +A + K R A + D P +K++A + A G+ A G V
Sbjct: 90 EEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVA 149
Query: 537 SVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGAD 596
++ P S++ +++ E P A+ P + + SSS TSS+
Sbjct: 150 NLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS--- 206
Query: 597 VDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPK--EEKSEEKGLSGLTT 654
E D + P + ++ S S K + A P K + + KG +
Sbjct: 207 ------SDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPA 260
Query: 655 LFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPAR 714
+ S S++G E E PA ++ ++++ +RA ASA P +
Sbjct: 261 KRAKKPEEESESSEEGSESE--EEAPAGTRSQVKASEKILQVRA-----ASAPAKGTPGK 313
Query: 715 LAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPE---PGGQQLK 771
A +P PG+ +A + G + S S+ S+ E P + L
Sbjct: 314 GATPAP------PGKAGAVA-------SQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 772 TRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLK 831
SG S+ A +P+ +S +K P G P V + + K
Sbjct: 361 QAKASGKTSQVGA-------ASAPAKESPRKGAAPAPPGKTGPAVAK--------AQAGK 405
Query: 832 FCTSNQEAIEKALNEEKVAYDRSPS 856
+Q + E++ +EE+ PS
Sbjct: 406 REEDSQSSSEESDSEEEAPAQAKPS 430
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 62.0 bits (149), Expect = 3e-09
Identities = 102/493 (20%), Positives = 182/493 (36%), Gaps = 71/493 (14%)
Query: 354 AKPASPAQVQSSQDGGCP--KEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKP 411
A P +P V S P + G+ +K G PAP + + K+K +K
Sbjct: 367 ASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKK-----DKE 421
Query: 412 RADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAA-- 469
R ++K A + R ++ + P + +T+ + P AR SP++ RPA+
Sbjct: 422 RENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPC 481
Query: 470 ---GRG---PPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFG 523
G G PP+P R +T +P G++ R+ E S P+ K ++ A
Sbjct: 482 PSPGPGHTLPPKPPS--PRGTTASPKGRV--RRKEEAKESPSAAGPEDKSQSKRRA---- 533
Query: 524 DESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSS 583
+E E+A P P+ P+ P+ + P A+ P + PP+PAP +
Sbjct: 534 -SNEKESAAPASPAPSPAPSPTPAPPQKEQ-------PPAETPTDAAVLTSPPAPAPPVT 585
Query: 584 SSSSSSTSSAGADVDYSALEK-----------------EVDFDSDPMEECLRIFNESTSV 626
S + ++ + EK + + D EE L E+ +
Sbjct: 586 PSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAE 645
Query: 627 KTEDRGRL----ARQPPKEEKSEEKGLSGLTTLFPGQKR---------RISHLSKQGQEV 673
+ + R AR+ + E+ E++ L + R R H +Q QE
Sbjct: 646 REAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQER 705
Query: 674 EPPRR--GPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKR 731
+ R+ + R E + + A+ S + + +SP + A ++
Sbjct: 706 QERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
Query: 732 RIAH-----IPNPRLAAAPTGAKRTLAA--SGSQSSNGPEPGGQQLKTRTLSGMASKTTT 784
I +P+ L A+ + L A S+NGP G + L + +
Sbjct: 766 PIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPS-GDKSLSRTPETLLPFAEAE 824
Query: 785 TIIPKRIAHSPSL 797
+ K + SP +
Sbjct: 825 AFLKKAVVQSPQV 837
Score = 34.3 bits (77), Expect = 0.75
Identities = 80/353 (22%), Positives = 124/353 (35%), Gaps = 59/353 (16%)
Query: 458 PSPTSGDSRPAA--GRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRA 515
P G P A R PP P P+ + P +L D P K A
Sbjct: 5 PRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPP------PMSALVPDTPPDTPPAMKNA 58
Query: 516 LSHADLFGDESEDEAAGPGVPS--VWPSALPSLSSDSDSDSDSSLGFPEAQGP----PKR 569
S L P PS V P P S++ S P A GP P R
Sbjct: 59 TSSKQL--------PLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPR 110
Query: 570 LKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSV--K 627
+ P P+ P+S S + + A E+ EE + +V +
Sbjct: 111 RSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERR--------EERAKYLAAKKAVWLE 162
Query: 628 TEDRGRLARQPPKEEKS---EEKGLSGLTTLFPGQKRRISHLSKQGQEVE--PPRRGPAV 682
E++ + R+ +E+ EE+ L ++RR + +Q Q++E R A+
Sbjct: 163 KEEKAKALREKQLQERRRRLEEQRLK-------AEQRRAALEERQRQKLEKNKERYEAAI 215
Query: 683 PPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLA 742
+ T E+ R Q+ A A +P S +SA + + I N RL+
Sbjct: 216 QRSVKKTWAEI---RQQRWSWAGALHHSSPGHKTSGS-RCSVSAVNLPKHVDSIINKRLS 271
Query: 743 AAPT------GAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPK 789
+ R+L S +SS +L T TLS +A + +P+
Sbjct: 272 KSSATLWNSPSRNRSLQLSAWESSI-----VDRLMTPTLSFLARSRSAVTLPR 319
Score = 31.6 bits (70), Expect = 4.8
Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 9/137 (6%)
Query: 339 ETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDK 398
E+ + ++G PP +P + + S +G P P P A K+
Sbjct: 2 ESGPRAELGAGAPPAVVARTPPEPRPSPEGD--PSPPPPPMSALVPDTPPDTPPAM-KNA 58
Query: 399 TKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRP 458
T K E P + + GP+ + P+ ++ E + P TP A R RP RR
Sbjct: 59 TSSKQLPLEPESP-SGQVGPRPAPPQEESPSSEAKSRGP---TPPAMGP--RDARPPRRS 112
Query: 459 SPTSGDSRPAAGRGPPR 475
S S + PA+ P +
Sbjct: 113 SQPSPTAVPASDSPPTK 129
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 61.2 bits (147), Expect = 6e-09
Identities = 168/823 (20%), Positives = 281/823 (34%), Gaps = 140/823 (17%)
Query: 69 QRENGTLGLGEEPRPDVLELELVNQAIEAVRS---EVELEQRRYRELLETTREHRSAEAP 125
+ E G +P ++ + + E S E ++E + ++L+ R+A AP
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV----RAASAP 229
Query: 126 ALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLASL 185
A G A+P P A +A G S + + + + P +K L +
Sbjct: 230 AKGTPGKGATPA--PPGKAGAVASQTKAGKPEEDSESSSEESSD-SEEETPAAKALLQAK 286
Query: 186 DRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKY--VVDNSRPPTDLEYDPLSNYSAR 243
G+ G A A PR+ + P P GK V ++ E S+ +
Sbjct: 287 ASGKTSQVGAASA-----PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 341
Query: 244 HLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPF--------------------GSCD 283
A ++ + + K P+ S P +P+K P
Sbjct: 342 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSS 401
Query: 284 ARFSDSEDEAATVP--------GNEPTTASTPKARADPEIKATGQ-PPSKEGL---EAEG 331
+ SDS+ EA G P P K G PP K G A+
Sbjct: 402 SEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQV 461
Query: 332 GGLRETKETAVQ--CDVGDLQPP----PAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPP 385
G E E++ + D D + P PA+ S + ++ P +G P+K A
Sbjct: 462 GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQ 521
Query: 386 APSCK--DGAQGKDKTKDKGRGR--PVEKPRADKKG----PQASSPRRKAERPEGTKKKP 437
+ K D ++ +++ D P A K PQ + +K K P
Sbjct: 522 VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAP 581
Query: 438 SSATPVATSGKGRPDRPA-RRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPS------- 489
A G PA P+ G RPA + K+ A +
Sbjct: 582 VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSV 641
Query: 490 GKLVERKARS------LDEGASQDAP----------KLKKRALSHADLFGDESEDEAAGP 533
GK ++ KA S L +G + P K +K+ S + +SE+ AA P
Sbjct: 642 GKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASP 701
Query: 534 GVPSVWPSALPSLSSDSDSDSDSSLGFPEAQG------------------PPKR------ 569
+ ++ + + + S+ G A G PP R
Sbjct: 702 AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNST 761
Query: 570 LKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTE 629
+ A P S + ++++ + G + D + E+E SD EE + S KT
Sbjct: 762 VLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE----SDSEEEAETLAQVKPSGKTH 817
Query: 630 D-RGRLA---RQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQG-------------QE 672
R LA P K G +G + G++ S++ Q
Sbjct: 818 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQV 877
Query: 673 VEPP------RRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISA 726
++PP R PA P A P AQ R +A ++A + + + P+
Sbjct: 878 IKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT 937
Query: 727 PGEKRRIAHIP--NPRLAAAPTGAKRTLAASGSQSSNGPEPGG 767
PG + + +P +PR+A + A + + S+ S+G + G
Sbjct: 938 PGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEG 980
Score = 43.9 bits (102), Expect = 0.001
Identities = 187/907 (20%), Positives = 282/907 (31%), Gaps = 185/907 (20%)
Query: 35 GARGSGA----PGDGGEAPPAAGLGY-------------DPYNPELPKPPAQRENGTLGL 77
G G GA PG G A P+A +G D + E+P A + +LG
Sbjct: 438 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGN 497
Query: 78 GEEPRPDVLELELVNQAIEAVRSEVELEQR--RYRELLETTREHRSAEAPALAPRGPNAS 135
+ +P + Q V +V+ E+ E++ S EAPA A A
Sbjct: 498 ILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA-AMTAAQAK 556
Query: 136 PTVG-PDEDAFPLAFD--------------YSPGSHGLLSPDAGYQPTPLAA---PAEPG 177
P + P A P + +P G + AG P PAE
Sbjct: 557 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 616
Query: 178 SKYSLASLDR---------GQGRGGGGGGALEYVPKAVSQPRRHS-----RPVPSGKYVV 223
S + + GQ + G G + KA S P + S PV GK
Sbjct: 617 SSSEESDSEEEKTGLAVTVGQAKSVGKGLQV----KAASVPVKGSLGQGTAPVLPGKTGP 672
Query: 224 DNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCD 283
++ + + D S S S E AA P + S T A
Sbjct: 673 TVTQVKAEKQEDSES-------SEEESDSEEAAASPAQVKTSVKKTQAKANPA------- 718
Query: 284 ARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGG----LRETKE 339
A + S + PG T A+ K R+ ++K + P + A G + +
Sbjct: 719 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 778
Query: 340 TAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKK---------------KTGAP 384
TA Q G P +S + S ++ + KP K + GA
Sbjct: 779 TAAQAQTG---PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 835
Query: 385 PAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAE----------RPEGTK 434
P P K G K G E+ +D + P A + + + P G
Sbjct: 836 PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPA 895
Query: 435 KKPSSATPVATSGKGRPDRPARRPSPTSGDSR---PAAGRGPP----RPLQLPDRKSTKA 487
P+ A +T K R R S + + PA P + +P A
Sbjct: 896 ATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 955
Query: 488 PSGKLV----ERKARSLDEGASQDAPK------------LKKRALSHADLFGDESE---- 527
P + +++ + +G Q+ P L + AL E++
Sbjct: 956 PKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVA 1015
Query: 528 --------DEAAG----------------------PGVPSVWPSA-LPSLSSDSDSDSDS 556
D A G P +P V + P S DS+ SDS
Sbjct: 1016 RTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDS 1075
Query: 557 SLGFPE-AQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEE 615
S G E +GP A P PS + + T++ ++ D A + + S M
Sbjct: 1076 SSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSL--LSGYMTP 1133
Query: 616 CLRIFNESTSVKTED-------RGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSK 668
L N S T LA + + K E K L P + +
Sbjct: 1134 GLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGT 1193
Query: 669 QGQEVEPPRRGPAVPPARPPTAQE---VCYLRAQ---QAQRASASLLQAPARLAEKSPSV 722
Q+ P++G P A Q C L + AS+++ L E+
Sbjct: 1194 TPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKK 1253
Query: 723 HISAPGEKRRIAHIPNPRLAAAPTGAKRTL---------AASGSQSSNGPEPGGQQLKTR 773
+ E R R + A RT A G ++S PE K +
Sbjct: 1254 VVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGK 1313
Query: 774 TLSGMAS 780
AS
Sbjct: 1314 AKRDKAS 1320
Score = 40.0 bits (92), Expect = 0.014
Identities = 57/240 (23%), Positives = 91/240 (37%), Gaps = 51/240 (21%)
Query: 299 NEPTTASTPKARADPEIK---------------------ATGQPPSKEGLEAEGGGLRET 337
+ P+ +ST A+ DP+ K A+G P K +G G +
Sbjct: 1151 SSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1210
Query: 338 KETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKD 397
A+Q ++ P + AQVQ+S + + ++KK D
Sbjct: 1211 STLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKV--------------VD 1256
Query: 398 KTKDKGR-GRPVEKPRADKKGPQASSPRRKAERPEGT-KKKPSSATP--VATSGKGRPDR 453
TK+ R G K + P A +PR K ++ G + +S +P +T+ KG+ R
Sbjct: 1257 TTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKR 1316
Query: 454 PARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKK 513
SGD + G+G L + + P +L +K EG Q PK KK
Sbjct: 1317 -----DKASGDVKEKKGKG-----SLGSQGAKDEPEEEL--QKGMGTVEGGDQSNPKSKK 1364
Score = 37.0 bits (84), Expect = 0.11
Identities = 66/304 (21%), Positives = 119/304 (39%), Gaps = 44/304 (14%)
Query: 481 DRKSTKAPSGKLVERKARSLDEGASQDAPK-LKKRALSH---ADLFGDESEDEAAGPGVP 536
+ + +A + K R A + D P +K++A + A G+ A G V
Sbjct: 90 EEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVA 149
Query: 537 SVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAG-- 594
++ P S++ +++ E P A+ P + + SSS TSS+
Sbjct: 150 NLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDE 209
Query: 595 ADVDYSALEK--EVDFDSDPME-------------ECLRIFNESTSVKTEDRGRLARQPP 639
DV+ A EK +V S P + + + +++ + K E+ + +
Sbjct: 210 TDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 269
Query: 640 KEEKSE--------EKGLSGLTTLFPGQKRRISHLSKQGQEVEPP-RRGPAVPPARPPTA 690
+ + E + SG T+ ++G PP + GPAV A+
Sbjct: 270 SDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKR 329
Query: 691 QEVCYLRAQQAQRASASLLQAPARL--AEKSPSVH-ISAPGEKRRIAHIPNPRLAAAPTG 747
+E +Q + S S +APA+ + K+P V SAP ++ +PR AAP
Sbjct: 330 EE----DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE-------SPRKGAAPAP 378
Query: 748 AKRT 751
++T
Sbjct: 379 PRKT 382
Score = 32.3 bits (72), Expect = 2.8
Identities = 48/191 (25%), Positives = 70/191 (36%), Gaps = 51/191 (26%)
Query: 258 RPRGSRGSEPY--TPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEI 315
R R G +P TP KK + E A+V + +T S KA+ D
Sbjct: 1269 RKRKLSGDQPAARTPRSKK--------KKKLGAGEGGEASVSPEKTSTTSKGKAKRD--- 1317
Query: 316 KATGQPPSKEGLEAEGG-GLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEG 374
KA+G K+G + G G ++ E +Q +G ++ GG +
Sbjct: 1318 KASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVE-----------------GG--DQS 1358
Query: 375 KPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTK 434
PK KK +K K R + EK KK +AS+ + +E P K
Sbjct: 1359 NPKSKK----------------EKKKSDKRKKDKEKKEKKKKAKKAST--KDSESPSQKK 1400
Query: 435 KKPSSATPVAT 445
KK T T
Sbjct: 1401 KKKKKKTAEQT 1411
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.130 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,083,275
Number of Sequences: 37866
Number of extensions: 3640124
Number of successful extensions: 30949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 1696
Number of HSP's that attempted gapping in prelim test: 20923
Number of HSP's gapped (non-prelim): 8768
length of query: 1221
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1107
effective length of database: 13,930,794
effective search space: 15421388958
effective search space used: 15421388958
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.